name: NR1I3_HUMAN Nuclear receptor subfamily 1 group I member 3 (sprot)

description: A nuclear receptor subfamily 1 group I member 3 that is encoded in the genome of human.


name: NR1D2_HUMAN Nuclear receptor subfamily 1 group D member 2 (sprot)

description: A nuclear receptor subfamily 1 group D member 2 that is encoded in the genome of human.


name: PSME4_HUMAN Proteasome activator complex subunit 4 (sprot)

description: A proteasome activator complex subunit 4 that is encoded in the genome of human.


CUL7_HUMAN Cullin-7 (sprot)

A cullin-7 that is encoded in the genome of human.


name: NWD1_HUMAN NACHT domain- and WD repeat-containing protein 1 (sprot)

description: A NACHT domain- and WD repeat-containing protein 1 that is encoded in the genome of human.


name: SHPRH_HUMAN E3 ubiquitin-protein ligase SHPRH (sprot)

description: An E3 ubiquitin-protein ligase SHPRH that is encoded in the genome of human.


name: SLMAP_HUMAN Sarcolemmal membrane-associated protein (sprot)

description: A sarcolemmal membrane-associated protein that is encoded in the genome of human.


name: GAPD1_HUMAN GTPase-activating protein and VPS9 domain-containing protein 1 (sprot)

description: A GTPase-activating protein and VPS9 domain-containing protein 1 that is encoded in the genome of human.


name: T132D_HUMAN Transmembrane protein 132D (sprot)

description: A transmembrane protein 132D that is encoded in the genome of human.


name: RHG19_HUMAN Rho GTPase-activating protein 19 (sprot)

description: A Rho GTPase-activating protein 19 that is encoded in the genome of human.


name: FRPD4_HUMAN FERM and PDZ domain-containing protein 4 (sprot)

description: A FERM and PDZ domain-containing protein 4 that is encoded in the genome of human.


name: CLCA4_HUMAN Calcium-activated chloride channel regulator 4 (sprot)

description: A calcium-activated chloride channel regulator 4 that is encoded in the genome of human.


name: K2C72_HUMAN Keratin, type II cytoskeletal 72 (sprot)

description: A keratin, type II cytoskeletal 72 that is encoded in the genome of human.


name: UBX2B_HUMAN UBX domain-containing protein 2B (sprot)

description: A UBX domain-containing protein 2B that is encoded in the genome of human.


name: positive regulation of mitotic centrosome separation

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that activates or increases the frequency, rate or extent of centrosome separation.


name: negative regulation of protein localization to centrosome

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome.


name: AT7L3_HUMAN Ataxin-7-like protein 3 (sprot)

description: An ataxin-7-like protein 3 that is encoded in the genome of human.


DUBm complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p.


name: MF13A_HUMAN Transmembrane protein 180 (sprot)

description: A transmembrane protein 180 that is encoded in the genome of human.


name: NAA25_HUMAN N-alpha-acetyltransferase 25, NatB auxiliary subunit (sprot)

description: An N-alpha-acetyltransferase 25, NatB auxiliary subunit that is encoded in the genome of human.


name: HAPR1_HUMAN HUWE1-associated protein modifying stress responses 1 (sprot)

description: A HUWE1-associated protein modifying stress responses 1 that is encoded in the genome of human.


name: FAKD3_HUMAN FAST kinase domain-containing protein 3, mitochondrial (sprot)

description: A FAST kinase domain-containing protein 3, mitochondrial that is encoded in the genome of human.


name: regulation of mitochondrial mRNA stability

description: Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs.


name: HECAM_HUMAN Hepatic and glial cell adhesion molecule (sprot)

description: A hepatic and glial cell adhesion molecule that is encoded in the genome of human.


name: MELT_HUMAN Ventricular zone-expressed PH domain-containing protein homolog 1 (sprot)

description: A ventricular zone-expressed PH domain-containing protein homolog 1 that is encoded in the genome of human.


name: RTP5_HUMAN Receptor-transporting protein 5 (sprot)

description: A receptor-transporting protein 5 that is encoded in the genome of human.


name: T132B_HUMAN Transmembrane protein 132B (sprot)

description: A transmembrane protein 132B that is encoded in the genome of human.


name: CND2_HUMAN Condensin complex subunit 2 (sprot)

description: A condensin complex subunit 2 that is encoded in the genome of human.


female meiosis chromosome separation

description: The process in which paired chromosomes are physically detached from each other during female meiosis.


name: PAF15_HUMAN PCNA-associated factor (sprot)

description: A PCNA-associated factor that is encoded in the genome of human.


name: SPCS2_HUMAN Signal peptidase complex subunit 2 (sprot)

description: A signal peptidase complex subunit 2 that is encoded in the genome of human.


name: EMC2_HUMAN ER membrane protein complex subunit 2 (sprot)

description: An ER membrane protein complex subunit 2 that is encoded in the genome of human.


name: extrinsic component of endoplasmic reticulum membrane

description: The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


name: FL2D_HUMAN Pre-mRNA-splicing regulator WTAP (sprot)

description: A pre-mRNA-splicing regulator WTAP that is encoded in the genome of human.


name: RNA N6-methyladenosine methyltransferase complex

description: A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B).


name: PSMD6_HUMAN 26S proteasome non-ATPase regulatory subunit 6 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 6 that is encoded in the genome of human.


name: HERP1_HUMAN Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (sprot)

description: A homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein that is encoded in the genome of human.


name: LAP4A_HUMAN Lysosomal-associated transmembrane protein 4A (sprot)

description: A lysosomal-associated transmembrane protein 4A that is encoded in the genome of human.


name: MD2BP_HUMAN MAD2L1-binding protein (sprot)

description: A MAD2L1-binding protein that is encoded in the genome of human.


name: deactivation of mitotic spindle assembly checkpoint

description: A positive regulation of the mitotic metaphase/anaphase transition that results from deactivation of the mitotic spindle assembly checkpoint.


name: MO4L2_HUMAN Mortality factor 4-like protein 2 (sprot)

description: A mortality factor 4-like protein 2 that is encoded in the genome of human.


name: ABRX2_HUMAN BRISC complex subunit Abraxas 2 (sprot)

description: A BRISC complex subunit Abraxas 2 that is encoded in the genome of human.


SEPT2_HUMAN Septin-2 (sprot)

A septin-2 that is encoded in the genome of human.


name: SART3_HUMAN Squamous cell carcinoma antigen recognized by T-cells 3 (sprot)

description: A squamous cell carcinoma antigen recognized by T-cells 3 that is encoded in the genome of human.


U6atac snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U6atac, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6atac snRNP, most of which remain associated with the U6atac snRNA both while the U6atac snRNP is free or assembled into the U4atac/U6atac snRNP or into a series of spliceosomal complexes.


U6atac snRNA binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to a U6atac small nuclear RNA (U6atac snRNA).


name: CND1_HUMAN Condensin complex subunit 1 (sprot)

description: A condensin complex subunit 1 that is encoded in the genome of human.


name: SUZ12_HUMAN Polycomb protein SUZ12 (sprot)

description: A polycomb protein SUZ12 that is encoded in the genome of human.


name: EXOS7_HUMAN Exosome complex component RRP42 (sprot)

description: An exosome complex component RRP42 that is encoded in the genome of human.


name: TNIP1_HUMAN TNFAIP3-interacting protein 1 (sprot)

description: A TNFAIP3-interacting protein 1 that is encoded in the genome of human.


name: positive regulation of protein deubiquitination

description: Any process that activates or increases the frequency, rate or extent of protein deubiquitination.


name: ACAP1_HUMAN Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (sprot)

description: An Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 that is encoded in the genome of human.


name: U5S1_HUMAN 116 kDa U5 small nuclear ribonucleoprotein component (sprot)

description: A 116 kDa U5 small nuclear ribonucleoprotein component that is encoded in the genome of human.


name: SYLM_HUMAN Leucine--tRNA ligase, mitochondrial (sprot)

description: A leucine--tRNA ligase, mitochondrial that is encoded in the genome of human.


leucine-tRNA ligase activity

description: Catalysis of the reaction: leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H+ + Leu-tRNA(Leu).


leucyl-tRNA aminoacylation

description: The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


name: R3HD1_HUMAN R3H domain-containing protein 1 (sprot)

description: An R3H domain-containing protein 1 that is encoded in the genome of human.


name: HERC3_HUMAN Probable E3 ubiquitin-protein ligase HERC3 (sprot)

description: A probable E3 ubiquitin-protein ligase HERC3 that is encoded in the genome of human.


name: TRAM2_HUMAN Translocating chain-associated membrane protein 2 (sprot)

description: A translocation-associated membrane protein 2 that is encoded in the genome of human.


SNX17_HUMAN Sorting nexin-17 (sprot)

A sorting nexin-17 that is encoded in the genome of human.


name: DAZP2_HUMAN DAZ-associated protein 2 (sprot)

description: A DAZ-associated protein 2 that is encoded in the genome of human.


JOS1_HUMAN Josephin-1 (sprot)

A josephin-1 that is encoded in the genome of human.


name: AR6P1_HUMAN ADP-ribosylation factor-like protein 6-interacting protein 1 (sprot)

description: An ADP-ribosylation factor-like protein 6-interacting protein 1 that is encoded in the genome of human.


name: endoplasmic reticulum tubular network membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane.


name: RB3GP_HUMAN Rab3 GTPase-activating protein catalytic subunit (sprot)

description: A Rab3 GTPase-activating protein catalytic subunit that is encoded in the genome of human.


name: positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization

description: Any process that activates or increases the frequency, rate or extent of glutamate secretion in response to membrane depolarization, where glutamate acts as a neurotransmitter.


name: positive regulation of endoplasmic reticulum tubular network organization

description: Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum tubular network organization.


name: S39AE_HUMAN Metal cation symporter ZIP14 (sprot)

description: A metal cation symporter ZIP14 that is encoded in the genome of human.


name: monoatomic anion:monoatomic cation symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in).


name: monoatomic cation:bicarbonate symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in).


manganese ion homeostasis

description: Any process involved in the maintenance of an internal steady state of manganese ions within an organism or cell.


SYK_HUMAN Lysine--tRNA ligase (sprot)

A eukaryotic-type lysine--tRNA ligase that is encoded in the genome of human.


name: ATP:ADP adenylyltransferase activity

description: Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate.


lysine-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).


lysyl-tRNA aminoacylation

description: The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.


name: SETB1_HUMAN Histone-lysine N-methyltransferase SETDB1 (sprot)

description: A histone-lysine N-methyltransferase SETDB1 that is encoded in the genome of human.


name: LRC14_HUMAN Leucine-rich repeat-containing protein 14 (sprot)

description: A leucine-rich repeat-containing protein 14 that is encoded in the genome of human.


name: MLC1_HUMAN Membrane protein MLC1 (sprot)

description: A membrane protein MLC1 that is encoded in the genome of human.


name: RRS1_HUMAN Ribosome biogenesis regulatory protein homolog (sprot)

description: A ribosome biogenesis regulatory protein that is encoded in the genome of human.


name: IQCB1_HUMAN IQ calmodulin-binding motif-containing protein 1 (sprot)

description: An IQ calmodulin-binding motif-containing protein 1 that is encoded in the genome of human.


BBSome binding

description: Binding to a BBSome complex.


cytosolic ciliogenesis

description: The process in which an axoneme is exposed entirely or partially to the cytoplasm or by which the cytoplasmic portion is assembled or extended. Cytosolic ciliogenesis can occur following compartmentalized ciliogenesis, in which the cilium is formed within a compartment separated from the cytoplasm.


name: ARHG6_HUMAN Rho guanine nucleotide exchange factor 6 (sprot)

description: A Rho guanine nucleotide exchange factor 6 that is encoded in the genome of human.


name: K0040_HUMAN Uncharacterized protein KIAA0040 (sprot)

description: A protein that is a translation product of the KIAA0040 gene in human.


name: DPOD3_HUMAN DNA polymerase delta subunit 3 (sprot)

description: A DNA polymerase delta subunit 3 that is encoded in the genome of human.


name: IF4H_HUMAN Eukaryotic translation initiation factor 4H (sprot)

description: A eukaryotic translation initiation factor 4H that is encoded in the genome of human.


name: ACAP2_HUMAN Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (sprot)

description: An Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 that is encoded in the genome of human.


name: KIF14_HUMAN Kinesin-like protein KIF14 (sprot)

description: A kinesin-like protein KIF14 that is encoded in the genome of human.


name: cerebellar granular layer structural organization

description: The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.


regulation of cell maturation

description: Any process that modulates the frequency, rate or extent of cell maturation.


name: BRD3_HUMAN Bromodomain-containing protein 3 (sprot)

description: A bromodomain-containing protein 3 that is encoded in the genome of human.


name: WDR43_HUMAN WD repeat-containing protein 43 (sprot)

description: A WD repeat-containing protein 43 that is encoded in the genome of human.


POSTN_HUMAN Periostin (sprot)

A periostin that is encoded in the genome of human.


name: ACOX1_HUMAN Peroxisomal acyl-coenzyme A oxidase 1 (sprot)

description: A peroxisomal acyl-coenzyme A oxidase 1 that is encoded in the genome of human.


name: very long-chain fatty acid beta-oxidation

description: A fatty acid beta-oxidation pathway acting on a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).


name: OXA1L_HUMAN Mitochondrial inner membrane protein OXA1L (sprot)

description: A mitochondrial inner membrane protein OXA1L that is encoded in the genome of human.


name: protein insertion into mitochondrial inner membrane from matrix

description: The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix.


mitochondrial protein quality control

description: The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the mitochondrion, which are targeted for degradation.


name: OZF_HUMAN Zinc finger protein OZF (sprot)

description: A zinc finger protein OZF that is encoded in the genome of human.


name: EEA1_HUMAN Early endosome antigen 1 (sprot)

description: An early endosome antigen 1 that is encoded in the genome of human.


name: chemical synaptic transmission, postsynaptic

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol.


description: An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate.


P2RY6_HUMAN P2Y purinoceptor 6 (sprot)

A P2Y purinoceptor 6 that is encoded in the genome of human.


G protein-coupled UDP receptor activity

description: Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP.


name: cellular response to pyrimidine ribonucleotide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus.


name: CD5R1_HUMAN Cyclin-dependent kinase 5 activator 1 (sprot)

description: A cyclin-dependent kinase 5 activator 1 that is encoded in the genome of human.


name: NCF4_HUMAN Neutrophil cytosol factor 4 (sprot)

description: A neutrophil cytosol factor 4 that is encoded in the genome of human.


name: PDIA6_HUMAN Protein disulfide-isomerase A6 (sprot)

description: A protein disulfide-isomerase A6 that is encoded in the genome of human.


name: PA1B3_HUMAN Platelet-activating factor acetylhydrolase IB subunit alpha1 (sprot)

description: A platelet-activating factor acetylhydrolase IB subunit alpha1 that is encoded in the genome of human.


name: RAGE_HUMAN Advanced glycosylation end product-specific receptor (sprot)

description: An advanced glycosylation end product-specific receptor that is encoded in the genome of human.


name: advanced glycation end-product receptor activity

description: Combining with advanced glycation end-products and transmitting the signal to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins).


name: regulation of T cell mediated cytotoxicity

description: Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity.


name: negative regulation of blood circulation

description: Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation.


name: positive regulation of endothelin production

description: Any process that activates or increases the frequency, rate or extent of endothelin production.


name: regulation of CD4-positive, alpha-beta T cell activation

description: Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation.


name: PLCL1_HUMAN Inactive phospholipase C-like protein 1 (sprot)

description: An inactive phospholipase C-like protein 1 that is encoded in the genome of human.


name: PCOC1_HUMAN Procollagen C-endopeptidase enhancer 1 (sprot)

description: A procollagen C-endopeptidase enhancer 1 that is encoded in the genome of human.


name: PDCD1_HUMAN Programmed cell death protein 1 (sprot)

description: A programmed cell death protein 1 that is encoded in the genome of human.


name: negative regulation of tolerance induction

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction.


regulatory T cell apoptotic process

description: Any apoptotic process in a regulatory T cell.


name: PDK1_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (sprot)

description: A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial that is encoded in the genome of human.


name: pyruvate dehydrogenase (acetyl-transferring) kinase activity

description: Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate.


name: regulation of acetyl-CoA biosynthetic process from pyruvate

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.


name: PDK2_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (sprot)

description: A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial that is encoded in the genome of human.


name: PDK3_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (sprot)

description: A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial that is encoded in the genome of human.


name: PEA15_HUMAN Astrocytic phosphoprotein PEA-15 (sprot)

description: An astrocytic phosphoprotein PEA-15 that is encoded in the genome of human.


name: PGM5_HUMAN Phosphoglucomutase-like protein 5 (sprot)

description: A phosphoglucomutase-like protein 5 that is encoded in the genome of human.


spot adherens junction

description: A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens.


A 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase that is encoded in the genome of human.


cholestenol delta-isomerase activity

description: Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol.


name: PMVK_HUMAN Phosphomevalonate kinase (sprot)

description: A phosphomevalonate kinase that is encoded in the genome of human.


phosphomevalonate kinase activity

description: Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H+.


name: CDK10_HUMAN Cyclin-dependent kinase 10 (sprot)

description: A cyclin-dependent kinase 10 that is encoded in the genome of human.


name: KPCD1_HUMAN Serine/threonine-protein kinase D1 (sprot)

description: A serine/threonine-protein kinase D1 that is encoded in the genome of human.


name: regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril

description: Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing calcium ion binding affinity of the myofibril.


name: PLCB4_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (sprot)

description: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 that is encoded in the genome of human.


name: phospholipase C-activating endothelin receptor signaling pathway

description: A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


PLEC_HUMAN Plectin (sprot)

A plectin-1 that is encoded in the genome of human.


protein-containing complex organization

description: Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex.


name: actomyosin contractile ring assembly actin filament organization

description: An actin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis.


name: PCM1_HUMAN Pericentriolar material 1 protein (sprot)

description: A pericentriolar material 1 protein that is encoded in the genome of human.


name: intraciliary transport involved in cilium assembly

description: The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.


name: protein-containing complex localization to centriolar satellite

description: A protein-containing complex localization by which the complex is transported to, or maintained in, the centriolar satellite.


name: NOMO1_HUMAN BOS complex subunit NOMO1 (sprot)

description: A BOS complex subunit NOMO1 that is encoded in the genome of human.


name: PON2_HUMAN Serum paraoxonase/arylesterase 2 (sprot)

description: A serum paraoxonase/arylesterase 2 that is encoded in the genome of human.


name: PON3_HUMAN Serum paraoxonase/lactonase 3 (sprot)

description: A serum paraoxonase/lactonase 3 that is encoded in the genome of human.


regulation of cellular response to drug

description: Any process that modulates the frequency, rate or extent of cellular response to drug.


name: TCAL1_HUMAN Transcription elongation factor A protein-like 1 (sprot)

description: A transcription elongation factor A protein-like 1 that is encoded in the genome of human.


name: 2A5A_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (sprot)

description: A serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform that is encoded in the genome of human.


name: negative regulation of lipid kinase activity

description: Any process that decreases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid.


name: 2A5B_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (sprot)

description: A serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform that is encoded in the genome of human.


name: positive regulation of neurotrophin TRK receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.


name: IPYR_HUMAN Inorganic pyrophosphatase (sprot)

description: An inorganic pyrophosphatase that is encoded in the genome of human.


name: TEBP_HUMAN Prostaglandin E synthase 3 (sprot)

description: A prostaglandin E synthase 3 that is encoded in the genome of human.


name: PLGA_HUMAN Plasminogen-like protein A (sprot)

description: A plasminogen-like protein A that is encoded in the genome of human.


name: PGFRL_HUMAN Platelet-derived growth factor receptor-like protein (sprot)

description: A platelet-derived growth factor receptor-like protein that is encoded in the genome of human.


name: STK38_HUMAN Serine/threonine-protein kinase 38 (sprot)

description: A serine/threonine-protein kinase 38 that is encoded in the genome of human.


UFM1-modified protein reader activity

description: A molecular adaptor recognizes and binds a target protein containing a UFM1 modification and brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.


NECT1_HUMAN Nectin-1 (sprot)

A nectin-1 that is encoded in the genome of human.


name: NONO_HUMAN Non-POU domain-containing octamer-binding protein (sprot)

description: A non-POU domain-containing octamer-binding protein that is encoded in the genome of human.


name: PSG5_HUMAN Pregnancy-specific beta-1-glycoprotein 5 (sprot)

description: A pregnancy-specific beta-1-glycoprotein 5 that is encoded in the genome of human.


name: PTPRR_HUMAN Receptor-type tyrosine-protein phosphatase R (sprot)

description: A receptor-type tyrosine-protein phosphatase R that is encoded in the genome of human.


name: PTPA_HUMAN Serine/threonine-protein phosphatase 2A activator (sprot)

description: A serine/threonine-protein phosphatase 2A regulatory subunit B' that is encoded in the genome of human.


name: PTPRK_HUMAN Receptor-type tyrosine-protein phosphatase kappa (sprot)

description: A receptor-type tyrosine-protein phosphatase kappa that is encoded in the genome of human.


name: PWP2_HUMAN Periodic tryptophan protein 2 homolog (sprot)

description: A periodic tryptophan protein 2 that is encoded in the genome of human.


name: NKX11_HUMAN NK1 transcription factor-related protein 1 (sprot)

description: An NK1 transcription factor-related protein 1 that is encoded in the genome of human.


name: NADC_HUMAN Nicotinate-nucleotide pyrophosphorylase [carboxylating] (sprot)

description: A nicotinate-nucleotide pyrophosphorylase [carboxylating] that is encoded in the genome of human.


quinolinate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.


name: nicotinate-nucleotide diphosphorylase (carboxylating) activity

description: Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate.


name: RABE1_HUMAN Rab GTPase-binding effector protein 1 (sprot)

description: A Rab GTPase-binding effector protein 1 that is encoded in the genome of human.


name: RASA2_HUMAN Ras GTPase-activating protein 2 (sprot)

description: A Ras GTPase-activating protein 2 that is encoded in the genome of human.


name: RAB35_HUMAN Ras-related protein Rab-35 (sprot)

description: A Ras-related protein Rab-35 that is encoded in the genome of human.


name: RNPS1_HUMAN RNA-binding protein with serine-rich domain 1 (sprot)

description: An RNA-binding protein with serine-rich domain 1 that is encoded in the genome of human.


name: RBBP5_HUMAN Retinoblastoma-binding protein 5 (sprot)

description: A retinoblastoma-binding protein 5 that is encoded in the genome of human.


RCN1_HUMAN Reticulocalbin-1 (sprot)

A reticulocalbin-1 that is encoded in the genome of human.


name: ERBB4_HUMAN Receptor tyrosine-protein kinase erbB-4 (sprot)

description: A receptor tyrosine-protein kinase erbB-4 that is encoded in the genome of human.


neuregulin receptor activity

description: Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: IRF4_HUMAN Interferon regulatory factor 4 (sprot)

description: An interferon regulatory factor 4 that is encoded in the genome of human.


name: RBP1_HUMAN RalA-binding protein 1 (sprot)

description: A RalA-binding protein 1 that is encoded in the genome of human.


doxorubicin transport

description: The directed movement of a doxorubicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: PO4F3_HUMAN POU domain, class 4, transcription factor 3 (sprot)

description: A POU domain, class 4, transcription factor 3 that is encoded in the genome of human.


name: K1H1_HUMAN Keratin, type I cuticular Ha1 (sprot)

description: A keratin, type I cuticular Ha1 that is encoded in the genome of human.


name: ZMY11_HUMAN Zinc finger MYND domain-containing protein 11 (sprot)

description: A zinc finger MYND domain-containing protein 11 that is encoded in the genome of human.


name: ANKR1_HUMAN Ankyrin repeat domain-containing protein 1 (sprot)

description: An ankyrin repeat domain-containing protein 1 that is encoded in the genome of human.


name: E2F5_HUMAN Transcription factor E2F5 (sprot)

description: A transcription factor E2F5 that is encoded in the genome of human.


name: L2GL1_HUMAN Lethal(2) giant larvae protein homolog 1 (sprot)

description: A lethal(2) giant larvae protein homolog 1 that is encoded in the genome of human.


name: LRC41_HUMAN Leucine-rich repeat-containing protein 41 (sprot)

description: A leucine-rich repeat-containing protein 41 that is encoded in the genome of human.


name: KS6A2_HUMAN Ribosomal protein S6 kinase alpha-2 (sprot)

description: A ribosomal protein S6 kinase alpha-2 that is encoded in the genome of human.


name: TTF1_HUMAN Transcription termination factor 1 (sprot)

description: A transcription termination factor 1 that is encoded in the genome of human.


name: termination of RNA polymerase I transcription

description: A transcription termination process that completes the production of a ribosomal RNA transcript. RNAP I termination requires binding of a terminator protein to specific sequences downstream of the transcription unit.


name: TMED2_HUMAN Transmembrane emp24 domain-containing protein 2 (sprot)

description: A transmembrane emp24 domain-containing protein 2 that is encoded in the genome of human.


name: maintenance of protein localization in organelle

description: Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.


regulation of SREBP signaling pathway

description: Any process that modulates the frequency, rate or extent of the SREBP signaling pathway.


name: PCBP1_HUMAN Poly(rC)-binding protein 1 (sprot)

description: A poly(rC)-binding protein 1 that is encoded in the genome of human.


viral RNA genome replication

description: The replication of a viral RNA genome.


name: PCBP2_HUMAN Poly(rC)-binding protein 2 (sprot)

description: A poly(rC)-binding protein 2 that is encoded in the genome of human.


name: promoter-enhancer loop anchoring activity

description: Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop.


ELOC_HUMAN Elongin-C (sprot)

An elongin-C that is encoded in the genome of human.


ELOB_HUMAN Elongin-B (sprot)

An elongin-B that is encoded in the genome of human.


name: EPHA7_HUMAN Ephrin type-A receptor 7 (sprot)

description: An ephrin type-A receptor 7 that is encoded in the genome of human.


name: RHEB_HUMAN GTP-binding protein Rheb (sprot)

description: A GTP-binding protein Rheb that is encoded in the genome of human.


name: UBE3C_HUMAN Ubiquitin-protein ligase E3C (sprot)

description: A ubiquitin-protein ligase E3C that is encoded in the genome of human.


name: TOM20_HUMAN Mitochondrial import receptor subunit TOM20 homolog (sprot)

description: A mitochondrial import receptor subunit TOM20 that is encoded in the genome of human.


protein-transporting ATPase activity

description: Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.


ANGP1_HUMAN Angiopoietin-1 (sprot)

An angiopoietin-1 that is encoded in the genome of human.


name: regulation of macrophage migration inhibitory factor signaling pathway

description: Any process that modulates the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway.


name: MTFR1_HUMAN Mitochondrial fission regulator 1 (sprot)

description: A mitochondrial fission regulator 1 that is encoded in the genome of human.


P2Y14_HUMAN P2Y purinoceptor 14 (sprot)

A P2Y purinoceptor 14 that is encoded in the genome of human.


name: DHC24_HUMAN Delta(24)-sterol reductase (sprot)

description: A Delta(24)-sterol reductase that is encoded in the genome of human.


delta24(24-1) sterol reductase activity

description: Catalysis of the reaction: ergosterol + NADP+ = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H+ + NADPH.


name: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.


delta24-sterol reductase activity

description: Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol.


name: SF3B3_HUMAN Splicing factor 3B subunit 3 (sprot)

description: A splicing factor 3B subunit 3 that is encoded in the genome of human.


PUM3_HUMAN Pumilio homolog 3 (sprot)

A pumilio homolog 3 that is encoded in the genome of human.


name: DLGP5_HUMAN Disks large-associated protein 5 (sprot)

description: A disks large-associated protein 5 that is encoded in the genome of human.


TLR1_HUMAN Toll-like receptor 1 (sprot)

A Toll-like receptor 1 that is encoded in the genome of human.


name: RSU1_HUMAN Ras suppressor protein 1 (sprot)

description: A Ras suppressor protein 1 that is encoded in the genome of human.


name: NR6A1_HUMAN Nuclear receptor subfamily 6 group A member 1 (sprot)

description: A nuclear receptor subfamily 6 group A member 1 that is encoded in the genome of human.


RYR3_HUMAN Ryanodine receptor 3 (sprot)

A ryanodine receptor 3 that is encoded in the genome of human.


name: RBY1F_HUMAN RNA-binding motif protein, Y chromosome, family 1 member F/J (sprot)

description: An RNA-binding motif protein, Y chromosome, family 1 member F/J that is encoded in the genome of human.


CNN3_HUMAN Calponin-3 (sprot)

A calponin-3 that is encoded in the genome of human.


name: KS6A1_HUMAN Ribosomal protein S6 kinase alpha-1 (sprot)

description: A ribosomal protein S6 kinase alpha-1 that is encoded in the genome of human.


name: SAFB1_HUMAN Scaffold attachment factor B1 (sprot)

description: A scaffold attachment factor B1 that is encoded in the genome of human.


name: SF3B4_HUMAN Splicing factor 3B subunit 4 (sprot)

description: A splicing factor 3B subunit 4 that is encoded in the genome of human.


name: SF3A2_HUMAN Splicing factor 3A subunit 2 (sprot)

description: A splicing factor 3A subunit 2 that is encoded in the genome of human.


name: SYCP1_HUMAN Synaptonemal complex protein 1 (sprot)

description: A synaptonemal complex protein 1 that is encoded in the genome of human.


name: RBMS2_HUMAN RNA-binding motif, single-stranded-interacting protein 2 (sprot)

description: An RNA-binding motif, single-stranded-interacting protein 2 that is encoded in the genome of human.


name: PP1R7_HUMAN Protein phosphatase 1 regulatory subunit 7 (sprot)

description: A protein phosphatase 1 regulatory subunit 7 that is encoded in the genome of human.


name: SC23A_HUMAN Protein transport protein Sec23A (sprot)

description: A protein transport protein Sec23A that is encoded in the genome of human.


name: SC23B_HUMAN Protein transport protein Sec23B (sprot)

description: A protein transport protein Sec23B that is encoded in the genome of human.


CYH1_HUMAN Cytohesin-1 (sprot)

A cytohesin-1 that is encoded in the genome of human.


name: SF3A1_HUMAN Splicing factor 3A subunit 1 (sprot)

description: A splicing factor 3 subunit 1 that is encoded in the genome of human.


name: SHB_HUMAN SH2 domain-containing adapter protein B (sprot)

description: An SH2 domain-containing adapter protein B that is encoded in the genome of human.


name: positive regulation of T-helper cell differentiation

description: Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation.


name: SHH_HUMAN Sonic hedgehog protein (sprot)

description: A sonic hedgehog protein that is encoded in the genome of human.


name: polarity specification of anterior/posterior axis

description: Any process resulting in the establishment of polarity along the anterior/posterior axis.


name: positive regulation of skeletal muscle cell proliferation

description: Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation.


trachea morphogenesis

description: The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches.


right lung development

description: The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect.


left lung development

description: The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect.


primary prostatic bud elongation

description: The increase in size of the prostatic bud as it forms.


regulation of prostatic bud formation

description: Any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth.


name: regulation of mesenchymal cell proliferation involved in prostate gland development

description: Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the prostate gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


name: mesenchymal smoothened signaling pathway involved in prostate gland development

description: The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein in the mesenchymal cells of the prostate that contribute to the progression of the prostate over time. This process contributes to lung development.


name: positive regulation of sclerotome development

description: Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.


tracheoesophageal septum formation

description: The process that gives rise to the tracheoesophageal septum. This process pertains to the initial formation of a structure from unspecified parts.


name: negative regulation of ureter smooth muscle cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation.


name: positive regulation of ureter smooth muscle cell differentiation

description: Any process that activates or increases the frequency, rate or extent of ureter smooth muscle cell differentiation.


name: negative regulation of kidney smooth muscle cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of kidney smooth muscle cell differentiation.


name: positive regulation of kidney smooth muscle cell differentiation

description: Any process that activates or increases the frequency, rate or extent of kidney smooth muscle cell differentiation.


name: positive regulation of mesenchymal cell proliferation involved in ureter development

description: Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in ureter development.


name: NR0B2_HUMAN Nuclear receptor subfamily 0 group B member 2 (sprot)

description: A nuclear receptor subfamily 0 group B member 2 that is encoded in the genome of human.


name: STIL_HUMAN SCL-interrupting locus protein (sprot)

description: An SCL-interrupting locus protein that is encoded in the genome of human.


name: SIX1_HUMAN Homeobox protein SIX1 (sprot)

description: A homeobox protein SIX1 that is encoded in the genome of human.


olfactory placode formation

description: The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.


myotome development

description: The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle.


fungiform papilla morphogenesis

description: The process in which the anatomical structures of the fungiform papilla are generated and organized. The fungiform papilla is a mushroom-shaped papilla of the tongue.


mesonephric tubule formation

description: The developmental process pertaining to the initial formation of a mesonephric tubule from unspecified parts. A mesonephric tubule is an epithelial tube that is part of the mesonephros.


name: mesenchymal cell proliferation involved in ureter development

description: The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureter, that contributes to ureter development.


name: cellular response to 3,3',5-triiodo-L-thyronine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',5-triiodo-L-thyronine stimulus.


name: SKI2_HUMAN Superkiller complex protein 2 (sprot)

description: A superkiller complex protein 2 that is encoded in the genome of human.


name: nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

description: The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.


Ski complex

description: A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p.


FCN2_HUMAN Ficolin-2 (sprot)

A ficolin-2 that is encoded in the genome of human.


mannan binding

description: Binding to mannan.


name: GUSP1_HUMAN Putative inactive beta-glucuronidase-like protein SMA3 (sprot)


RGN_HUMAN Regucalcin (sprot)

A regucalcin that is encoded in the genome of human.


gluconolactonase activity

description: Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate.


name: negative regulation of DNA catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process.


name: SP17_HUMAN Sperm surface protein Sp17 (sprot)

description: A sperm surface protein Sp17 that is encoded in the genome of human.


CDSN_HUMAN Corneodesmosin (sprot)

A corneodesmosin that is encoded in the genome of human.


corneocyte desquamation

description: The delamination process that results in the shedding of a corneocyte from the surface of the epidermis.


negative regulation of cornification

description: Any process that stops, prevents or reduces the frequency, rate or extent of cornification.


name: SURF1_HUMAN Surfeit locus protein 1 (sprot)

description: A surfeit locus protein 1 that is encoded in the genome of human.


name: SURF2_HUMAN Surfeit locus protein 2 (sprot)

description: A surfeit locus protein 2 that is encoded in the genome of human.


name: MED22_HUMAN Mediator of RNA polymerase II transcription subunit 22 (sprot)

description: A mediator of RNA polymerase II transcription subunit 22 that is encoded in the genome of human.


SSXT_HUMAN Protein SSXT (sprot)

A protein SSXT that is encoded in the genome of human.


name: TAF5_HUMAN Transcription initiation factor TFIID subunit 5 (sprot)

description: A transcription initiation factor TFIID subunit 5 that is encoded in the genome of human.


name: TAF13_HUMAN Transcription initiation factor TFIID subunit 13 (sprot)

description: A transcription initiation factor TFIID subunit 13 that is encoded in the genome of human.


name: TAF11_HUMAN Transcription initiation factor TFIID subunit 11 (sprot)

description: A transcription initiation factor TFIID subunit 11 that is encoded in the genome of human.


name: TAF7_HUMAN Transcription initiation factor TFIID subunit 7 (sprot)

description: A transcription initiation factor TFIID subunit 7 that is encoded in the genome of human.


spermine transport

description: The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: negative regulation of MHC class I biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.


name: PAQRB_HUMAN Monocyte to macrophage differentiation factor (sprot)

description: A monocyte to macrophage differentiation protein that is encoded in the genome of human.


name: TERF2_HUMAN Telomeric repeat-binding factor 2 (sprot)

description: A telomeric repeat-binding factor 2 that is encoded in the genome of human.


telomeric loop formation

description: The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region.


name: negative regulation of telomere maintenance via recombination

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length.


name: axonal transport of messenger ribonucleoprotein complex

description: The directed movement of a messenger ribonucleoprotein complex along microtubules in axons.


name: negative regulation of beta-galactosidase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of beta-galactosidase activity.


name: negative regulation of telomere single strand break repair

description: Any process that stops, prevents or reduces the frequency, rate or extent of telomere single strand break repair.


name: MARE2_HUMAN Microtubule-associated protein RP/EB family member 2 (sprot)

description: A microtubule-associated protein RP/EB family member 2 that is encoded in the genome of human.


name: TCEA2_HUMAN Transcription elongation factor A protein 2 (sprot)

description: A transcription elongation factor A protein 2 that is encoded in the genome of human.


DNA-templated transcription elongation

description: The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.


name: TEAD4_HUMAN Transcriptional enhancer factor TEF-3 (sprot)

description: A transcriptional enhancer factor TEF-3 that is encoded in the genome of human.


trophectodermal cell fate commitment

description: The cell fate commitment of precursor cells that will become trophectoderm cells.


name: TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (sprot)

description: A transcriptional enhancer factor TEF-4 that is encoded in the genome of human.


name: TESK1_HUMAN Dual specificity testis-specific protein kinase 1 (sprot)

description: A dual specificity testis-specific protein kinase 1 that is encoded in the genome of human.


name: TAF1C_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit C (sprot)

description: A TATA box-binding protein-associated factor RNA polymerase I subunit C that is encoded in the genome of human.


name: TAF1A_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit A (sprot)

description: A TATA box-binding protein-associated factor RNA polymerase I subunit A that is encoded in the genome of human.


name: BGH3_HUMAN Transforming growth factor-beta-induced protein ig-h3 (sprot)

description: A transforming growth factor-beta-induced protein ig-h3 that is encoded in the genome of human.


name: TGIF1_HUMAN Homeobox protein TGIF1 (sprot)

description: A homeobox protein TGIF1 that is encoded in the genome of human.


name: NCOA2_HUMAN Nuclear receptor coactivator 2 (sprot)

description: A nuclear receptor coactivator 2 that is encoded in the genome of human.


name: NHRF2_HUMAN Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (sprot)

description: A Na(+)/H(+) exchange regulatory cofactor NHE-RF2 that is encoded in the genome of human.


DIXC1_HUMAN Dixin (sprot)

A dixin that is encoded in the genome of human.


name: OR1Q1_HUMAN Olfactory receptor 1Q1 (sprot)

description: An olfactory receptor 1Q1 that is encoded in the genome of human.


name: OR4D1_HUMAN Olfactory receptor 4D1 (sprot)

description: An olfactory receptor 4D1 that is encoded in the genome of human.


name: OR8G1_HUMAN Olfactory receptor 8G1 (sprot)

description: An olfactory receptor 8G1 that is encoded in the genome of human.


name: OR1C1_HUMAN Olfactory receptor 1C1 (sprot)

description: An olfactory receptor 1C1 that is encoded in the genome of human.


name: OR8B8_HUMAN Olfactory receptor 8B8 (sprot)

description: An olfactory receptor 8B8 that is encoded in the genome of human.


name: OR7A5_HUMAN Olfactory receptor 7A5 (sprot)

description: An olfactory receptor 7A5 that is encoded in the genome of human.


name: TRADD_HUMAN Tumor necrosis factor receptor type 1-associated DEATH domain protein (sprot)

description: A tumor necrosis factor receptor type 1-associated DEATH domain protein that is encoded in the genome of human.


name: TRAM1_HUMAN Translocating chain-associated membrane protein 1 (sprot)

description: A translocation-associated membrane protein 1 that is encoded in the genome of human.


TSN_HUMAN Translin (sprot)

A translin that is encoded in the genome of human.


endoribonuclease complex

description: A protein complex which is capable of endoribonuclease activity.


name: TRBP2_HUMAN RISC-loading complex subunit TARBP2 (sprot)

description: A RISC-loading complex subunit TARBP2 that is encoded in the genome of human.


regulation of viral transcription

description: Any process that modulates the frequency, rate or extent of the transcription of the viral genome.


regulation of siRNA processing

description: Any process that modulates the frequency, rate or extent of siRNA processing.


global gene silencing by mRNA cleavage

description: A posttranscriptional gene silencing pathway that involves the cleavage of mRNAs in a non-gene-specific manner.


regulation of miRNA processing

description: Any process that modulates the frequency, rate or extent of microRNA processing.


SF01_HUMAN Splicing factor 1 (sprot)

A splicing factor 1 that is encoded in the genome of human.


nuclear body organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.


name: CIP4_HUMAN Cdc42-interacting protein 4 (sprot)

description: A Cdc42-interacting protein 4 that is encoded in the genome of human.


name: TRIPB_HUMAN Thyroid receptor-interacting protein 11 (sprot)

description: A thyroid receptor-interacting protein 11 that is encoded in the genome of human.


vesicle tethering to Golgi

description: The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.


name: PCH2_HUMAN Pachytene checkpoint protein 2 homolog (sprot)

description: A thyroid receptor-interacting protein 13 that is encoded in the genome of human.


name: OASL_HUMAN 2'-5'-oligoadenylate synthase-like protein (sprot)

description: A 2'-5'-oligoadenylate synthase-like protein 1 that is encoded in the genome of human.


name: MED1_HUMAN Mediator of RNA polymerase II transcription subunit 1 (sprot)

description: A mediator of RNA polymerase II transcription subunit 1 that is encoded in the genome of human.


name: thyroid hormone receptor signaling pathway

description: A nuclear receptor-mediated signaling pathway initiated by a thyroid hormone  binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


enucleate erythrocyte development

description: The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.


name: ZNHI3_HUMAN Zinc finger HIT domain-containing protein 3 (sprot)

description: A zinc finger HIT domain-containing protein 3 that is encoded in the genome of human.


name: TRIP4_HUMAN Activating signal cointegrator 1 (sprot)

description: An activating signal cointegrator 1 that is encoded in the genome of human.


name: activating signal cointegrator 1 complex

description: A protein complex that contains TRIP4 (ASC1) and acts a transcriptional coactivator by interacting with transcription factors such as NF-kappa B. In humans this complex has 4 subunits: TRIP4 + ASCC1-3.


RQC-trigger complex

description: A ribosome disassembly complex which dissociates stalled ribsome subunits as part of the ribosome quality control pathway. RQT complex is composed of a RNA helicase-family protein yeast Rqt2 (human ASCC3), a ubiquitin-binding protein yeast Rqt3, (human ASCC2), and Rqt4 (Human TRIP4).


name: HMGN3_HUMAN High mobility group nucleosome-binding domain-containing protein 3 (sprot)

description: A high mobility group nucleosome-binding domain-containing protein 3 that is encoded in the genome of human.


name: JHD2C_HUMAN Probable JmjC domain-containing histone demethylation protein 2C (sprot)

description: A probable JmjC domain-containing histone demethylation protein 2C that is encoded in the genome of human.


dioxygenase activity

description: Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products.


name: IKBB_HUMAN NF-kappa-B inhibitor beta (sprot)

description: An NF-kappa-B inhibitor beta that is encoded in the genome of human.


name: TRIP6_HUMAN Thyroid receptor-interacting protein 6 (sprot)

description: A thyroid receptor-interacting protein 6 that is encoded in the genome of human.


name: TRYB1_HUMAN Tryptase alpha/beta-1 (sprot)

description: A tryptase alpha/beta-1 that is encoded in the genome of human.


name: RHOH_HUMAN Rho-related GTP-binding protein RhoH (sprot)

description: A Rho-related GTP-binding protein RhoH that is encoded in the genome of human.


name: TWST1_HUMAN Twist-related protein 1 (sprot)

description: A twist-related protein 1 that is encoded in the genome of human.


embryonic camera-type eye formation

description: The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape.


name: negative regulation of double-strand break repair

description: Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair.


name: cell proliferation involved in heart valve development

description: Any cell proliferation that is involved in heart valve development.


name: positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation

description: Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation.


name: PTN14_HUMAN Tyrosine-protein phosphatase non-receptor type 14 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 14 that is encoded in the genome of human.


name: MARE1_HUMAN Microtubule-associated protein RP/EB family member 1 (sprot)

description: A microtubule-associated protein RP/EB family member 1 that is encoded in the genome of human.


name: protein localization to astral microtubule

description: A process in which a protein is transported to, or maintained in, a location within an astral microtubule.


cortical microtubule cytoskeleton

description: The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane.


mitotic spindle astral microtubule end

description: Any microtubule end that is part of a mitotic spindle astral microtubule.


name: U2AFL_HUMAN U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (sprot)

description: A U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 that is encoded in the genome of human.


name: U2AFM_HUMAN U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (sprot)

description: A U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 that is encoded in the genome of human.


name: ZN174_HUMAN Zinc finger protein 174 (sprot)

description: A zinc finger protein 174 that is encoded in the genome of human.


name: ALX1_HUMAN ALX homeobox protein 1 (sprot)

description: An ALX homeobox protein 1 that is encoded in the genome of human.


ATX8_HUMAN Ataxin-8 (sprot)

An ataxin-8 that is encoded in the genome of human.


name: DLG2_HUMAN Disks large homolog 2 (sprot)

description: A disks large homolog 2 that is encoded in the genome of human.


name: T22D1_HUMAN TSC22 domain family protein 1 (sprot)

description: A TSC22 domain family protein 1 that is encoded in the genome of human.


ELAV1_HUMAN ELAV-like protein 1 (sprot)

An ELAV-like protein 1 that is encoded in the genome of human.


name: LT4R1_HUMAN Leukotriene B4 receptor 1 (sprot)

description: A leukotriene B4 receptor 1 that is encoded in the genome of human.


leukotriene receptor activity

description: Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine.


name: ELF2_HUMAN ETS-related transcription factor Elf-2 (sprot)

description: An ETS-related transcription factor Elf-2 that is encoded in the genome of human.


name: KISS1_HUMAN Metastasis-suppressor KiSS-1 (sprot)

description: A metastasis-suppressor KiSS-1 that is encoded in the genome of human.


generation of ovulation cycle rhythm

description: The process which controls the timing of the type of sexual cycle seen in female mammals.


name: PI5PA_HUMAN Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (sprot)

description: A phosphatidylinositol 4,5-bisphosphate 5-phosphatase A that is encoded in the genome of human.


name: NSDHL_HUMAN Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (sprot)

description: A sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating that is encoded in the genome of human.


name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity

description: Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H.


name: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity

description: Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one.


description: Catalysis of the reaction: a 3beta-hydroxysteroid-4alpha-carboxylate + NAD+ = a 3-oxosteroid + CO2 + NADH.


name: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity

description: Catalysis of the reaction: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 4alpha-methyl-5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H.


name: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity

description: Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H.


name: NAB2_HUMAN NGFI-A-binding protein 2 (sprot)

description: An NGFI-A-binding protein 2 that is encoded in the genome of human.


name: OGR1_HUMAN Ovarian cancer G-protein coupled receptor 1 (sprot)

description: A sphingosylphosphorylcholine receptor that is encoded in the genome of human.


name: CEBPE_HUMAN CCAAT/enhancer-binding protein epsilon (sprot)

description: A CCAAT/enhancer-binding protein epsilon that is encoded in the genome of human.


name: MYLK_HUMAN Myosin light chain kinase, smooth muscle (sprot)

description: A myosin light chain kinase, smooth muscle that is encoded in the genome of human.


myosin light chain kinase activity

description: Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate.


tonic smooth muscle contraction

description: A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction.


name: TAB1_HUMAN TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (sprot)

description: A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of human.


name: HERC1_HUMAN Probable E3 ubiquitin-protein ligase HERC1 (sprot)

description: A probable E3 ubiquitin-protein ligase HERC1 that is encoded in the genome of human.


name: AAAT_HUMAN Neutral amino acid transporter B(0) (sprot)

description: A neutral amino acid transporter B(0) that is encoded in the genome of human.


glutamine secretion

description: The controlled release of glutamine by a cell.


name: L-glutamine import across plasma membrane

description: The directed movement of L-glutamine from outside of a cell, across the plasma membrane and into the cytosol.


name: MK11_HUMAN Mitogen-activated protein kinase 11 (sprot)

description: A mitogen-activated protein kinase 11 that is encoded in the genome of human.


name: GPR19_HUMAN Probable G-protein coupled receptor 19 (sprot)

description: A probable G-protein coupled receptor 19 that is encoded in the genome of human.


name: NPY5R_HUMAN Neuropeptide Y receptor type 5 (sprot)

description: A neuropeptide Y receptor type 5 that is encoded in the genome of human.


CD226_HUMAN CD226 antigen (sprot)

A CD226 molecule that is encoded in the genome of human.


name: positive regulation of mast cell activation

description: Any process that activates or increases the frequency, rate, or extent of mast cell activation.


EFNB3_HUMAN Ephrin-B3 (sprot)

An ephrin-B3 that is encoded in the genome of human.


axon choice point recognition

description: The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth.


name: positive regulation of presynapse assembly

description: Any process that activates or increases the frequency, rate or extent of presynapse assembly.


name: RAB30_HUMAN Ras-related protein Rab-30 (sprot)

description: A Ras-related protein Rab-30 that is encoded in the genome of human.


name: SPEG_HUMAN Striated muscle preferentially expressed protein kinase (sprot)

description: A striated muscle preferentially expressed protein kinase that is encoded in the genome of human.


name: MLF2_HUMAN Myeloid leukemia factor 2 (sprot)

description: A myeloid leukemia factor 2 that is encoded in the genome of human.


name: ZKSC8_HUMAN Zinc finger protein with KRAB and SCAN domains 8 (sprot)

description: A zinc finger protein with KRAB and SCAN domains 8 that is encoded in the genome of human.


name: MPPD2_HUMAN Metallophosphoesterase MPPED2 (sprot)

description: A metallophosphoesterase MPPED2 that is encoded in the genome of human.


GMP binding

description: Binding to GMP, guanosine monophosphate.


name: CH3L2_HUMAN Chitinase-3-like protein 2 (sprot)

description: A chitinase-3-like protein 2 that is encoded in the genome of human.


name: NDF2_HUMAN Neurogenic differentiation factor 2 (sprot)

description: A neurogenic differentiation factor 2 that is encoded in the genome of human.


name: TOM34_HUMAN Mitochondrial import receptor subunit TOM34 (sprot)

description: A mitochondrial import receptor subunit TOM34 that is encoded in the genome of human.


name: NCOA1_HUMAN Nuclear receptor coactivator 1 (sprot)

description: A nuclear receptor coactivator 1 that is encoded in the genome of human.


name: positive regulation of transcription from RNA polymerase II promoter by galactose

description: Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter.


name: SMAD2_HUMAN Mothers against decapentaplegic homolog 2 (sprot)

description: A smad2 that is encoded in the genome of human.


regulation of binding

description: Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.


homomeric SMAD protein complex

description: A protein complex composed of a single type of SMAD family proteins. In the absence of Smad4, phosphorylation of R-SMADs results in their homotrimerization. However, these complexes do not appear to import into the nucleus and are assumed to be transcriptionally inactive.


name: SMAD1_HUMAN Mothers against decapentaplegic homolog 1 (sprot)

description: A smad1 that is encoded in the genome of human.


mesodermal cell fate commitment

description: The cell differentiation process that results in commitment of a cell to become part of the mesoderm.


name: MSMO1_HUMAN Methylsterol monooxygenase 1 (sprot)

description: A methylsterol monooxygenase 1 that is encoded in the genome of human.


C-4 methylsterol oxidase activity

description: Catalysis of the reaction: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H+ + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O.


ITSN1_HUMAN Intersectin-1 (sprot)

An intersectin-1 that is encoded in the genome of human.


name: TBCE_HUMAN Tubulin-specific chaperone E (sprot)

description: A tubulin-specific chaperone E that is encoded in the genome of human.


name: TBCC_HUMAN Tubulin-specific chaperone C (sprot)

description: A tubulin-specific chaperone C that is encoded in the genome of human.


name: NPTX1_HUMAN Neuronal pentraxin-1 (sprot)

description: A neuronal pentraxin-1 that is encoded in the genome of human.


name: UB2V2_HUMAN Ubiquitin-conjugating enzyme E2 variant 2 (sprot)

description: A ubiquitin-conjugating enzyme E2 variant 2 that is encoded in the genome of human.


error-free postreplication DNA repair

description: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate.


name: ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-2 that is encoded in the genome of human.


name: modulation of inhibitory postsynaptic potential

description: Any process that modulates the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.


neuron projection cytoplasm

description: All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection.


name: ACHA6_HUMAN Neuronal acetylcholine receptor subunit alpha-6 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-6 that is encoded in the genome of human.


CYTM_HUMAN Cystatin-M (sprot)

A cystatin-M that is encoded in the genome of human.


name: STK11_HUMAN Serine/threonine-protein kinase STK11 (sprot)

description: A serine/threonine-protein kinase STK11 that is encoded in the genome of human.


dendrite extension

description: Long distance growth of a single dendrite involved in cellular development.


name: positive regulation of vesicle transport along microtubule

description: Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule.


description: A protein-containing complex located intracellularly.


name: STXB2_HUMAN Syntaxin-binding protein 2 (sprot)

description: A syntaxin-binding protein 2 that is encoded in the genome of human.


leukocyte mediated cytotoxicity

description: The directed killing of a target cell by a leukocyte.


name: CC85B_HUMAN Coiled-coil domain-containing protein 85B (sprot)

description: A coiled-coil domain-containing protein 85B that is encoded in the genome of human.


name: GRK1_HUMAN Rhodopsin kinase GRK1 (sprot)

description: A rhodopsin kinase GRK1 that is encoded in the genome of human.


name: VAMP3_HUMAN Vesicle-associated membrane protein 3 (sprot)

description: A vesicle-associated membrane protein 3 that is encoded in the genome of human.


name: negative regulation of secretion by cell

description: Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell.


name: KCNJ8_HUMAN ATP-sensitive inward rectifier potassium channel 8 (sprot)

description: An ATP-sensitive inward rectifier potassium channel 8 that is encoded in the genome of human.


NLRP3 inflammasome complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell.


name: atrioventricular node cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node.


NEDD8_HUMAN NEDD8 (sprot)

A NEDD8 protein that is encoded in the genome of human.


name: ADIRF_HUMAN Adipogenesis regulatory factor (sprot)

description: An adipogenesis regulatory factor that is encoded in the genome of human.


ADIPO_HUMAN Adiponectin (sprot)

An adiponectin that is encoded in the genome of human.


name: positive regulation of myeloid cell apoptotic process

description: Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process.


name: positive regulation of fatty acid metabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.


detection of oxidative stress

description: The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal.


name: negative regulation of intracellular protein transport

description: Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.


name: positive regulation of lipid transporter activity

description: Any process that increases the frequency, rate, or extent of lipid transporter activity.


name: positive regulation of metanephric podocyte development

description: Any process that activates or increases the frequency, rate or extent of metanephric glomerular visceral epithelial cell development.


name: positive regulation of renal albumin absorption

description: Any process that activates or increases the frequency, rate or extent of renal albumin absorption.


name: negative regulation of metanephric mesenchymal cell migration

description: Any process that stops, prevents or reduces the frequency, rate or extent of metanephric mesenchymal cell migration.


UT2_HUMAN Urea transporter 2 (sprot)

A urea transporter 2 that is encoded in the genome of human.


name: USF2_HUMAN Upstream stimulatory factor 2 (sprot)

description: An upstream stimulatory factor 2 that is encoded in the genome of human.


name: SCN9A_HUMAN Sodium channel protein type 9 subunit alpha (sprot)

description: A sodium channel protein type 9 subunit alpha that is encoded in the genome of human.


name: CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E (sprot)

description: A voltage-dependent R-type calcium channel subunit alpha-1E that is encoded in the genome of human.


name: EREP1_HUMAN Endosomal transmembrane epsin interactor 1 (sprot)

description: An endosomal transmembrane epsin interactor 1 that is encoded in the genome of human.


name: negative adaptation of signaling pathway

description: The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.


name: VAS1_HUMAN V-type proton ATPase subunit S1 (sprot)

description: A V-type proton ATPase subunit S1 that is encoded in the genome of human.


transporter activator activity

description: Binds to and increases the activity of a transporter.


name: VPS72_HUMAN Vacuolar protein sorting-associated protein 72 homolog (sprot)

description: A vacuolar protein sorting-associated protein 72 that is encoded in the genome of human.


name: ATP-dependent H2AZ histone chaperone activity

description: A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite.


name: RB11B_HUMAN Ras-related protein Rab-11B (sprot)

description: A Ras-related protein Rab-11B that is encoded in the genome of human.


name: EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (sprot)

description: A histone-lysine N-methyltransferase EZH2 that is encoded in the genome of human.


name: histone H3K27 methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein.


name: histone H3K27 trimethyltransferase activity

description: Catalysis of the reaction: L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me3.


regulation of gliogenesis

description: Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia.


name: regulatory ncRNA-mediated heterochromatin formation

description: A heterochromatin formation-based gene silencing process mediated by a regulatory non-coding RNA molecule that occur before the beginning of trancription.


hepatocyte homeostasis

description: Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules.


regulation of kidney development

description: Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


name: ZFHX3_HUMAN Zinc finger homeobox protein 3 (sprot)

description: A zinc finger homeobox protein 3 that is encoded in the genome of human.


name: ZIC1_HUMAN Zinc finger protein ZIC 1 (sprot)

description: A zinc finger protein ZIC 1 that is encoded in the genome of human.


maintenance of cell number

description: Any process by which the numbers of cells of a particular type or in a tissue are maintained.


name: ZBTB6_HUMAN Zinc finger and BTB domain-containing protein 6 (sprot)

description: A zinc finger and BTB domain-containing protein 6 that is encoded in the genome of human.


name: ZN141_HUMAN Zinc finger protein 141 (sprot)

description: A zinc finger protein 141 that is encoded in the genome of human.


name: ZNF77_HUMAN Zinc finger protein 77 (sprot)

description: A zinc finger protein 77 that is encoded in the genome of human.


name: ZNF79_HUMAN Zinc finger protein 79 (sprot)

description: A zinc finger protein 79 that is encoded in the genome of human.


name: ZNF67_HUMAN Putative zinc finger protein 726P1 (sprot)


ZYX_HUMAN Zyxin (sprot)

A zyxin that is encoded in the genome of human.


name: ZN124_HUMAN Zinc finger protein 124 (sprot)

description: A zinc finger protein 124 that is encoded in the genome of human.


name: MCHL1_HUMAN Putative pro-MCH-like protein 1 (sprot)

description: A putative pro-MCH-like protein 1 that is encoded in the genome of human.


name: HSPB2_HUMAN Heat shock protein beta-2 (sprot)

description: A heat shock protein beta-2 that is encoded in the genome of human.


name: GRIK4_HUMAN Glutamate receptor ionotropic, kainate 4 (sprot)

description: A glutamate receptor ionotropic, kainate 4 that is encoded in the genome of human.


name: ETFD_HUMAN Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (sprot)

description: An electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial that is encoded in the genome of human.


description: Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein].


SYUB_HUMAN Beta-synuclein (sprot)

A beta-synuclein that is encoded in the genome of human.


SEPT7_HUMAN Septin-7 (sprot)

A septin-7 that is encoded in the genome of human.


name: ADRM1_HUMAN Proteasomal ubiquitin receptor ADRM1 (sprot)

description: A proteasomal ubiquitin receptor ADRM1 that is encoded in the genome of human.


name: CCDC6_HUMAN Coiled-coil domain-containing protein 6 (sprot)

description: A coiled-coil domain-containing protein 6 that is encoded in the genome of human.


name: ENOX2_HUMAN Ecto-NOX disulfide-thiol exchanger 2 (sprot)

description: An ecto-NOX disulfide-thiol exchanger 2 that is encoded in the genome of human.


ultradian rhythm

description: The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours.


name: UAP1_HUMAN UDP-N-acetylhexosamine pyrophosphorylase (sprot)

description: A UDP-N-acetylhexosamine pyrophosphorylase that is encoded in the genome of human.


description: Catalysis of the reaction: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-galactosamine.


name: protein serine pyrophosphorylase activity

description: Catalysis of the reaction: protein phospho-serine + inositol 5-triphosphate pentakisphosphate = protein diphospho-serine + inositol 5-diphosphate pentakisphosphate.


name: NF2L2_HUMAN Nuclear factor erythroid 2-related factor 2 (sprot)

description: A nuclear factor erythroid 2-related factor 2 that is encoded in the genome of human.


aflatoxin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.


name: positive regulation of glutathione biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of glutathione biosynthetic process.


name: E2F4_HUMAN Transcription factor E2F4 (sprot)

description: A transcription factor E2F4 that is encoded in the genome of human.


name: IBP7_HUMAN Insulin-like growth factor-binding protein 7 (sprot)

description: An insulin-like growth factor-binding protein 7 that is encoded in the genome of human.


name: CNGA2_HUMAN Cyclic nucleotide-gated channel alpha-2 (sprot)

description: A cyclic nucleotide-gated olfactory channel that is encoded in the genome of human.


name: CNGA3_HUMAN Cyclic nucleotide-gated channel alpha-3 (sprot)

description: A cyclic nucleotide-gated cation channel alpha-3 that is encoded in the genome of human.


name: NTRK3_HUMAN NT-3 growth factor receptor (sprot)

description: An NT-3 growth factor receptor that is encoded in the genome of human.


name: KCA10_HUMAN Potassium voltage-gated channel subfamily A member 10 (sprot)

description: A voltage-gated potassium channel subunit KCNA10 that is encoded in the genome of human.


name: intracellularly cyclic nucleotide-activated monoatomic cation channel activity

description: Enables the transmembrane transfer of a monoatomic cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts.


name: PDCD2_HUMAN Programmed cell death protein 2 (sprot)

description: A programmed cell death protein 2 that is encoded in the genome of human.


name: S15A2_HUMAN Solute carrier family 15 member 2 (sprot)

description: A solute carrier family 15 member 2 that is encoded in the genome of human.


peptidoglycan transport

description: The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


dipeptide transport

description: The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


AINX_HUMAN Alpha-internexin (sprot)

An alpha-internexin that is encoded in the genome of human.


name: LAMA4_HUMAN Laminin subunit alpha-4 (sprot)

description: A laminin subunit alpha-4 that is encoded in the genome of human.


name: PROL4_HUMAN Proline-rich protein 4 (sprot)

description: A proline-rich protein 4 that is encoded in the genome of human.


SSX1_HUMAN Protein SSX1 (sprot)

A protein SSX1 that is encoded in the genome of human.


SSX2_HUMAN Protein SSX2 (sprot)

A protein SSX2 that is encoded in the genome of human.


EXT1_HUMAN Exostosin-1 (sprot)

An exostosin-1 that is encoded in the genome of human.


description: Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP.


name: heparan sulfate N-acetylglucosaminyltransferase activity

description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate.


description: Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP.


polysaccharide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.


hypersensitivity

description: An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system.


heart field specification

description: The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop.


chondroitin sulfate metabolic process

description: The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.


name: lymphocyte adhesion to endothelial cell of high endothelial venule

description: The attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream.


fluid transport

description: The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: smoothened signaling pathway involved in lung development

description: The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein. This process contributes to lung development.


sweat gland development

description: The progression of the sweat gland over time, from its formation to the mature structure. Sweat glands secrete an aqueous solution that is used in thermoregulation.


perichondral bone morphogenesis

description: The process in which bones are generated and organized as a result of the conversion of initial connective tissue surrounding cartilage into bone.


response to heparin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus.


name: mesenchymal cell differentiation involved in bone development

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state.


name: PSMD5_HUMAN 26S proteasome non-ATPase regulatory subunit 5 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 5 that is encoded in the genome of human.


name: GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-6 that is encoded in the genome of human.


name: cerebellar Golgi cell to granule cell synapse

description: A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell.


name: TENXA_HUMAN Putative tenascin-XA (sprot)


name: GRIK5_HUMAN Glutamate receptor ionotropic, kainate 5 (sprot)

description: A glutamate receptor ionotropic, kainate 5 that is encoded in the genome of human.


name: PKN1_HUMAN Serine/threonine-protein kinase N1 (sprot)

description: A serine/threonine-protein kinase N1 that is encoded in the genome of human.


name: PKN2_HUMAN Serine/threonine-protein kinase N2 (sprot)

description: A serine/threonine-protein kinase N2 that is encoded in the genome of human.


name: TAF12_HUMAN Transcription initiation factor TFIID subunit 12 (sprot)

description: A transcription initiation factor TFIID subunit 12 that is encoded in the genome of human.


name: ASIC2_HUMAN Acid-sensing ion channel 2 (sprot)

description: An acid-sensing ion channel 2 that is encoded in the genome of human.


name: regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback

description: The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control.


NNAT_HUMAN Neuronatin (sprot)

A neuronatin that is encoded in the genome of human.


name: RPE65_HUMAN Retinoid isomerohydrolase (sprot)

description: A retinal pigment epithelium-specific 65 kDa protein that is encoded in the genome of human.


name: all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity

description: Catalysis of the reaction: H2O + all-trans-retinyl palmitate = 11-cis-retinol + H+ + palmitate.


name: all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity

description: Catalysis of the reaction: H2O + all-trans-retinyl ester = 11-cis-retinol + fatty acid.


zeaxanthin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of zeaxanthin.


name: BATF_HUMAN Basic leucine zipper transcriptional factor ATF-like (sprot)

description: A basic leucine zipper transcriptional factor ATF-like that is encoded in the genome of human.


CRY1_HUMAN Cryptochrome-1 (sprot)

A cryptochrome-1 that is encoded in the genome of human.


blue light photoreceptor activity

description: The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation.


blue light signaling pathway

description: The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm.


name: negative regulation of glucocorticoid secretion

description: Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid secretion.


name: CSRP2_HUMAN Cysteine and glycine-rich protein 2 (sprot)

description: A cysteine and glycine-rich protein 2 that is encoded in the genome of human.


name: DDB1_HUMAN DNA damage-binding protein 1 (sprot)

description: A DNA damage-binding protein 1 that is encoded in the genome of human.


name: SNPC1_HUMAN snRNA-activating protein complex subunit 1 (sprot)

description: An snRNA-activating protein complex subunit 1 that is encoded in the genome of human.


name: HLF_HUMAN Hepatic leukemia factor (sprot)

description: A hepatic leukemia factor that is encoded in the genome of human.


name: 2A5E_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (sprot)

description: A serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform that is encoded in the genome of human.


name: GP162_HUMAN Probable G-protein coupled receptor 162 (sprot)

description: A probable G-protein coupled receptor 162 that is encoded in the genome of human.


name: MK14_HUMAN Mitogen-activated protein kinase 14 (sprot)

description: A mitogen-activated protein kinase 14 that is encoded in the genome of human.


name: RM23_HUMAN Large ribosomal subunit protein uL23m (sprot)

description: A large ribosomal subunit protein uL23m that is encoded in the genome of human.


name: CDC37_HUMAN Hsp90 co-chaperone Cdc37 (sprot)

description: An Hsp90 co-chaperone Cdc37 that is encoded in the genome of human.


name: B2LA1_HUMAN Bcl-2-related protein A1 (sprot)

description: A Bcl-2-related protein A1 that is encoded in the genome of human.


name: PCSK7_HUMAN Proprotein convertase subtilisin/kexin type 7 (sprot)

description: A proprotein convertase subtilisin/kexin type 7 that is encoded in the genome of human.


IL17_HUMAN Interleukin-17A (sprot)

An interleukin-17A that is encoded in the genome of human.


name: positive regulation of interleukin-16 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-16 production.