regulation of T cell anergy

description: Any process that modulates the frequency, rate, or extent of T cell anergy.


regulation of MAPK cascade

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.


regulation of JNK cascade

description: Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.


FZD6_HUMAN Frizzled-6 (sprot)

A frizzled-6 that is encoded in the genome of human.


cell proliferation in midbrain

description: The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain.


embryonic nail plate morphogenesis

description: The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits.


name: establishment of body hair planar orientation

description: Orientation of body hairs, projections from the surface of an organism, such that the hairs all point in a uniform direction along the surface.


midbrain morphogenesis

description: The developmental process by which a midbrain is generated and organized.


NUPR1_HUMAN Nuclear protein 1 (sprot)

A nuclear protein 1 that is encoded in the genome of human.


acute inflammatory response

description: Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.


name: positive regulation of protein modification process

description: Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


fibroblast apoptotic process

description: Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.


name: negative regulation of glycolytic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.


name: negative regulation of fibroblast proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.


name: negative regulation of programmed necrotic cell death

description: Any process that decreases the frequency, rate or extent of programmed necrotic cell death.


name: positive regulation of neuroinflammatory response

description: Any process that activates or increases the frequency, rate or extent of neuroinflammatory response.


name: negative regulation of autophagosome assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly.


name: positive regulation of oxidative phosphorylation

description: Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation.


name: negative regulation of type B pancreatic cell proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation.


name: regulation of response to endoplasmic reticulum stress

description: Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress.


regulation of female gonad development

description: Any process that modulates the frequency, rate or extent of female gonad development.


name: CCG3_HUMAN Voltage-dependent calcium channel gamma-3 subunit (sprot)

description: A voltage-dependent calcium channel gamma-3 subunit that is encoded in the genome of human.


name: neurotransmitter receptor localization to postsynaptic specialization membrane

description: A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).


somatodendritic compartment

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.


name: NDK8_HUMAN Putative nucleoside diphosphate kinase (sprot)

description: A protein that is a translation product of the NME2P1 gene in human.


name: HBP1_HUMAN HMG box-containing protein 1 (sprot)

description: An HMG box-containing protein 1 that is encoded in the genome of human.


name: GDF9_HUMAN Growth/differentiation factor 9 (sprot)

description: A growth/differentiation factor 9 that is encoded in the genome of human.


regulation of progesterone secretion

description: Any process that modulates the frequency, rate or extent of progesterone secretion.


name: ZN861_HUMAN Putative zinc finger protein 861 (sprot)


name: NMD3B_HUMAN Glutamate receptor ionotropic, NMDA 3B (sprot)

description: A glutamate receptor ionotropic, NMDA 3B that is encoded in the genome of human.


calcium channel activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Enables the energy-independent facilitated diffusion of a calcium ion through a transmembrane aqueous pore or channel.


monoatomic cation channel activity

description: Enables the energy-independent facilitated diffusion of a monoatomic cation through a transmembrane aqueous pore or channel.


glycine binding

description: Binding to glycine, aminoethanoic acid.


neurotransmitter receptor activity

description: Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.


protein insertion into membrane

description: The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.


name: NOBOX_HUMAN Homeobox protein NOBOX (sprot)

description: A homeobox protein NOBOX that is encoded in the genome of human.


name: COX7S_HUMAN Putative cytochrome c oxidase subunit 7A3, mitochondrial (sprot)


name: O10H2_HUMAN Olfactory receptor 10H2 (sprot)

description: An olfactory receptor 10H2 that is encoded in the genome of human.


name: O10H3_HUMAN Olfactory receptor 10H3 (sprot)

description: An olfactory receptor 10H3 that is encoded in the genome of human.


name: OR7C2_HUMAN Olfactory receptor 7C2 (sprot)

description: An olfactory receptor 7C2 that is encoded in the genome of human.


name: ONEC3_HUMAN One cut domain family member 3 (sprot)

description: An one cut domain family member 3 that is encoded in the genome of human.


name: AT8B3_HUMAN Phospholipid-transporting ATPase IK (sprot)

description: A phospholipid-transporting ATPase IK that is encoded in the genome of human.


name: FADS1_HUMAN Acyl-CoA (8-3)-desaturase (sprot)

description: An acyl-CoA (8-3)-desaturase that is encoded in the genome of human.


name: long-chain fatty acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


C-5 sterol desaturase activity

description: Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.


linoleoyl-CoA desaturase activity

description: Catalysis of the reaction: (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-CoA and add a fourth double bond (a (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA).


omega-6 fatty acid desaturase activity

description: Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain.


acyl-CoA delta5-desaturase activity

description: Catalysis of the reaction: (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA) and add a fourth double bond (a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA).


linoleic acid metabolic process

description: The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.


icosanoid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids.


name: OR1I1_HUMAN Olfactory receptor 1I1 (sprot)

description: An olfactory receptor 1I1 that is encoded in the genome of human.


PEPL_HUMAN Periplakin (sprot)

A periplakin that is encoded in the genome of human.


desmosome

description: A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.


GSDME_HUMAN Gasdermin-E (sprot)

A gasdermin-E that is encoded in the genome of human.


wide pore channel activity

description: Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.


name: positive regulation of immune response to tumor cell

description: Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell.


name: EVI5_HUMAN Ecotropic viral integration site 5 protein homolog (sprot)

description: An ecotropic viral integration site 5 protein that is encoded in the genome of human.


name: LY75_HUMAN Lymphocyte antigen 75 (sprot)

description: A protein that is either lymphocyte antigen 75 isoform 4 (human), LY75-CD302 fusion protein isoform V34-2 (human), or LY75-CD302 fusion protein isoform V33-2 (human).


NRP2_HUMAN Neuropilin-2 (sprot)

A neuropilin-2 that is encoded in the genome of human.


name: DSCAM_HUMAN Cell adhesion molecule DSCAM (sprot)

description: A cell adhesion molecule DSCAM that is encoded in the genome of human.


protein tyrosine kinase binding

description: Binding to protein tyrosine kinase.


netrin receptor binding

description: Binding to a netrin receptor.


name: post-embryonic retina morphogenesis in camera-type eye

description: The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage.


dendrite self-avoidance

description: The process in which dendrites recognize and avoid contact with sister dendrites from the same cell.


name: MA1A2_HUMAN Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (sprot)

description: A mannosyl-oligosaccharide 1,2-alpha-mannosidase IB that is encoded in the genome of human.


description: Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.


name: BRNP1_HUMAN BMP/retinoic acid-inducible neural-specific protein 1 (sprot)

description: A BMP/retinoic acid-inducible neural-specific protein 1 that is encoded in the genome of human.


maternal behavior

description: Female behaviors associated with the care and rearing of offspring.


vocalization behavior

description: The behavior in which an organism produces sounds by a mechanism involving its respiratory system.


name: G137B_HUMAN Integral membrane protein GPR137B (sprot)

description: An integral membrane protein GPR137B that is encoded in the genome of human.


name: positive regulation of protein localization to lysosome

description: Any process that activates or increases the frequency, rate or extent of protein localization to lysosome.


name: DLX3_HUMAN Homeobox protein DLX-3 (sprot)

description: A homeobox protein DLX-3 that is encoded in the genome of human.


hair cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a hair cell.


hair follicle cell proliferation

description: The multiplication or reproduction of hair follicle cells, resulting in the expansion of a cell population.


odontoblast differentiation

description: The process in which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a cell on the outer surface of the dental pulp whose biological function is the creation of dentin.


name: ZIC3_HUMAN Zinc finger protein ZIC 3 (sprot)

description: A zinc finger protein ZIC 3 that is encoded in the genome of human.


neural plate development

description: The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.


name: atrial cardiac muscle tissue development

description: The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure.


name: germ-line stem cell population maintenance

description: Any process by which an organism or tissue maintains a population of germ-line stem cells.


central nervous system segmentation

description: Division of the central nervous system into a series of semi-repetitive parts or segments.


name: determination of pancreatic left/right asymmetry

description: Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism.


name: determination of left/right asymmetry in nervous system

description: The establishment of the nervous system with respect to the left and right halves.


axial mesoderm development

description: The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.


paraxial mesoderm development

description: The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube.


face development

description: The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.


name: determination of digestive tract left/right asymmetry

description: Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed.


name: determination of liver left/right asymmetry

description: Determination of the asymmetric location of the liver with respect to the left and right halves of the organism.


PLXC1_HUMAN Plexin-C1 (sprot)

A plexin-C1 that is encoded in the genome of human.


name: MPZL2_HUMAN Myelin protein zero-like protein 2 (sprot)

description: A myelin protein zero-like protein 2 that is encoded in the genome of human.


name: ACSL4_HUMAN Long-chain-fatty-acid--CoA ligase 4 (sprot)

description: A long-chain-fatty-acid--CoA ligase 4 that is encoded in the genome of human.


palmitoyl-CoA ligase activity

description: Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA.


name: embryonic process involved in female pregnancy

description: A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.


SNX3_HUMAN Sorting nexin-3 (sprot)

A sorting nexin-3 that is encoded in the genome of human.


retromer complex

description: A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35.


description: Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.


retromer complex binding

description: Binding to a retromer complex.


intralumenal vesicle formation

description: The invagination of the endosome membrane and resulting formation of a vesicle within the lumen of the endosome.


name: negative regulation of early endosome to late endosome transport

description: Any process that stops, prevents or reduces the frequency, rate or extent of early endosome to late endosome transport.


CUBN_HUMAN Cubilin (sprot)

A cubilin that is encoded in the genome of human.


cobalamin binding

description: Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.


name: extrinsic component of external side of plasma membrane

description: The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.


DOK2_HUMAN Docking protein 2 (sprot)

A docking protein 2 that is encoded in the genome of human.


name: transmembrane receptor protein tyrosine kinase adaptor activity

description: The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.


STX10_HUMAN Syntaxin-10 (sprot)

A syntaxin-10 that is encoded in the genome of human.


NPHN_HUMAN Nephrin (sprot)

A nephrin that is encoded in the genome of human.


name: glomerular basement membrane development

description: The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration.


protein localization to synapse

description: Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.


slit diaphragm assembly

description: The aggregation, arrangement and bonding together of a set of components to form a slit diaphragm, specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.


OGA_HUMAN Protein O-GlcNAcase (sprot)

A protein O-GlcNAcase that is encoded in the genome of human.


description: Catalysis of the reaction: 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl/L-threonyl-[protein] + H2O = L-seryl//L-threonyl-[protein] + N-acetyl-D-glucosamine.


N-acetylglucosamine metabolic process

description: The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.


name: ADCY9_HUMAN Adenylate cyclase type 9 (sprot)

description: An adenylate cyclase type 9 that is encoded in the genome of human.


name: adenylate cyclase-activating adrenergic receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process.


VINEX_HUMAN Vinexin (sprot)

A vinexin that is encoded in the genome of human.


name: positive regulation of cytoskeleton organization

description: Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.


name: HNRPQ_HUMAN Heterogeneous nuclear ribonucleoprotein Q (sprot)

description: A heterogeneous nuclear ribonucleoprotein Q that is encoded in the genome of human.


name: negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

description: Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.


name: positive regulation of cytoplasmic translation

description: Any process that activates or increases the frequency, rate or extent of cytoplasmic translation.


CRD-mediated mRNA stability complex

description: A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9.


mCRD-mediated mRNA stability complex

description: A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP.


name: histone pre-mRNA 3'end processing complex

description: A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1.


GAIT complex

description: A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.


name: TPST1_HUMAN Protein-tyrosine sulfotransferase 1 (sprot)

description: A protein-tyrosine sulfotransferase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.


post-translational protein modification

description: The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.


name: PRP17_HUMAN Pre-mRNA-processing factor 17 (sprot)

description: A pre-mRNA-processing factor 17 that is encoded in the genome of human.


embryonic brain development

description: The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure.


name: B4GT3_HUMAN Beta-1,4-galactosyltransferase 3 (sprot)

description: A beta-1,4-galactosyltransferase 3 that is encoded in the genome of human.


description: Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide.


name: B4GT4_HUMAN Beta-1,4-galactosyltransferase 4 (sprot)

description: A beta-1,4-galactosyltransferase 4 that is encoded in the genome of human.


UDP-galactosyltransferase activity

description: Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule.


lactosylceramide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides.


membrane lipid metabolic process

description: The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane.


name: 4EBP3_HUMAN Eukaryotic translation initiation factor 4E-binding protein 3 (sprot)

description: A eukaryotic translation initiation factor 4E-binding protein 3 that is encoded in the genome of human.


name: RNBP6_HUMAN Ran-binding protein 6 (sprot)

description: A Ran-binding protein 6 that is encoded in the genome of human.


name: CRBL2_HUMAN cAMP-responsive element-binding protein-like 2 (sprot)

description: A cAMP-responsive element-binding protein-like 2 that is encoded in the genome of human.


name: TDRD6_HUMAN Tudor domain-containing protein 6 (sprot)

description: A tudor domain-containing protein 6 that is encoded in the genome of human.


name: NEMF_HUMAN Ribosome quality control complex subunit NEMF (sprot)

description: A serologically defined colon cancer antigen 1 that is encoded in the genome of human.


ribosomal large subunit binding

description: Binding to a large ribosomal subunit.


nuclear export

description: The directed movement of substances out of the nucleus.


rescue of stalled ribosome

description: A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex.


CAT tailing

description: The C-terminal elongation of 60S-anchored stalled nascent polypeptide chains with untemplated alanine and threonine tails (CAT tails). CAT tails participate in the recognition of stalled nascent chains by the ribosome quality control system.


name: ribosome-associated ubiquitin-dependent protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein.


cytosolic ribosome

description: A ribosome located in the cytosol.


RQC complex

description: A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins.


PSPN_HUMAN Persephin (sprot)

A persephin that is encoded in the genome of human.


name: glial cell-derived neurotrophic factor receptor binding

description: A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors.


name: CIDEA_HUMAN Lipid transferase CIDEA (sprot)

description: A lipid transferase CIDEA that is encoded in the genome of human.


temperature homeostasis

description: A homeostatic process in which an organism modulates its internal body temperature.


name: negative regulation of cytokine production

description: Any process that stops, prevents, or reduces the rate of production of a cytokine.


response to stilbenoid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones.


name: negative regulation of lipid catabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.


lipid droplet fusion

description: The process by which a single lipid droplet is created from the fusion of two or more lipid droplets.


name: GMDS_HUMAN GDP-mannose 4,6 dehydratase (sprot)

description: A GDP-mannose 4,6 dehydratase that is encoded in the genome of human.


GDP-mannose 4,6-dehydratase activity

description: Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H2O.


NADP+ binding

description: Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.


GDP-mannose metabolic process

description: The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate.


name: 'de novo' GDP-L-fucose biosynthetic process

description: The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271).


name: FOXD2_HUMAN Forkhead box protein D2 (sprot)

description: A forkhead box protein D2 that is encoded in the genome of human.


name: NMT2_HUMAN Glycylpeptide N-tetradecanoyltransferase 2 (sprot)

description: A glycylpeptide N-tetradecanoyltransferase 2 that is encoded in the genome of human.


description: Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide.


description: Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule.


description: The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine.


name: regulation of opsin-mediated signaling pathway

description: Any process that modulates the frequency, rate or extent of opsin-mediated signaling.


intracellular transport of virus

description: The directed movement of a virus, or part of a virus, within the host cell.


CCNT1_HUMAN Cyclin-T1 (sprot)

A cyclin-T1 that is encoded in the genome of human.


name: cyclin-dependent protein serine/threonine kinase activator activity

description: Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase.


7SK snRNA binding

description: Binding to a 7SK small nuclear RNA (7SK snRNA).


molecular condensate scaffold activity

description: Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate.


name: regulation of cyclin-dependent protein serine/threonine kinase activity

description: Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.


name: cyclin/CDK positive transcription elongation factor complex

description: A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.


P-TEFb complex

description: A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T.


GREM1_HUMAN Gremlin-1 (sprot)

A gremlin-1 that is encoded in the genome of human.


name: regulation of stress-activated MAPK cascade

description: Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.


name: signal transduction by p53 class mediator

description: An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein.


morphogen activity

description: Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient.


name: vascular endothelial growth factor receptor 2 binding

description: Binding to a vascular endothelial growth factor receptor 2.


name: positive regulation of receptor internalization

description: Any process that activates or increases the frequency, rate or extent of receptor internalization.


name: mesenchymal to epithelial transition involved in metanephros morphogenesis

description: A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.


embryonic limb morphogenesis

description: The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.


name: negative regulation of bone mineralization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.


negative regulation of bone remodeling

description: Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling.


determination of dorsal identity

description: Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


ureteric bud formation

description: The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud.


name: negative regulation of monocyte chemotaxis

description: Any process that decreases the frequency, rate, or extent of monocyte chemotaxis.


name: positive regulation of branching involved in ureteric bud morphogenesis

description: Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.


name: negative regulation of osteoclast proliferation

description: Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.


name: positive regulation of peptidyl-tyrosine autophosphorylation

description: Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.


name: negative regulation of bone mineralization involved in bone maturation

description: Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation.


name: positive regulation of signaling receptor activity

description: Any process that activates or increases the frequency, rate or extent of signaling receptor activity.


name: BUB1B_HUMAN Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (sprot)

description: A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human.


name: metaphase/anaphase transition of mitotic cell cycle

description: The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.


name: protein localization to chromosome, centromeric region

description: Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome.


name: PLOD3_HUMAN Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (sprot)

description: A multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 that is encoded in the genome of human.


description: Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine.


endothelial cell morphogenesis

description: The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.


collagen metabolic process

description: The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).


vasodilation

description: An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure.


basement membrane assembly

description: The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue.


name: IF4E2_HUMAN Eukaryotic translation initiation factor 4E type 2 (sprot)

description: A eukaryotic translation initiation factor 4E type 2 that is encoded in the genome of human.


RNA 7-methylguanosine cap binding

description: Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.


name: ISK4_HUMAN Serine protease inhibitor Kazal-type 4 (sprot)

description: A serine protease inhibitor Kazal-type 4 that is encoded in the genome of human.


CCNT2_HUMAN Cyclin-T2 (sprot)

A cyclin-T2 that is encoded in the genome of human.


early viral transcription

description: The first phase of viral transcription that occurs after entry of the virus into the host cell, but prior to viral genome replication. It involves the transcription of genes for non-structural proteins, and for lytic viruses, the early gene products are involved in establishing control over the host cell.


late viral transcription

description: The transcription of the final group of viral genes of the viral life cycle, following middle transcription, or where middle transcription doesn't occur, following early transcription. Involves the transcription of genes encoding structural proteins.


TLR5_HUMAN Toll-like receptor 5 (sprot)

A Toll-like receptor 5 that is encoded in the genome of human.


interleukin-1 receptor binding

description: Binding to an interleukin-1 receptor.


toll-like receptor 5 signaling pathway

description: The series of molecular signals initiated by a ligand binding to toll-like receptor 5.


TLR2_HUMAN Toll-like receptor 2 (sprot)

A Toll-like receptor 2 that is encoded in the genome of human.


name: detection of triacyl bacterial lipopeptide

description: The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups.


name: detection of diacyl bacterial lipopeptide

description: The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups.


name: cellular response to diacyl bacterial lipopeptide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus.


name: cellular response to triacyl bacterial lipopeptide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus.


Toll-like receptor binding

description: Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.


triacyl lipopeptide binding

description: Binding to a lipopeptide containing a nonprotein moiety consisting of three acyl groups.


peptidoglycan binding

description: Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.


leukotriene metabolic process

description: The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.


microglia development

description: The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.


central nervous system myelin formation

description: The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.


name: positive regulation of interleukin-18 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.


name: toll-like receptor TLR6:TLR2 signaling pathway

description: The series of molecular signals initiated by a ligand binding of a heterodimeric TLR6:TLR2 complex, followed by transmission of the signal by the activated receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


nitric oxide metabolic process

description: The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.


negative regulation of synapse assembly

description: Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.


name: cellular response to bacterial lipopeptide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus.


name: Toll-like receptor 1-Toll-like receptor 2 protein complex

description: A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2).


name: Toll-like receptor 2-Toll-like receptor 6 protein complex

description: A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6).


name: GFRA3_HUMAN GDNF family receptor alpha-3 (sprot)

description: A GDNF family receptor alpha-3 that is encoded in the genome of human.


axon guidance receptor activity

description: Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.


name: DIAP1_HUMAN Protein diaphanous homolog 1 (sprot)

description: A protein diaphanous homolog 1 that is encoded in the genome of human.


regulation of microtubule-based process

description: Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.


name: regulation of release of sequestered calcium ion into cytosol

description: Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.


cellular response to histamine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.


SEP15_HUMAN Selenoprotein F (sprot)

A selenoprotein F that is encoded in the genome of human.


thioredoxin peroxidase activity

description: Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O.


selenium binding

description: Binding to a selenium (Se) ion.


sperm DNA condensation

description: The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication.


name: 'de novo' post-translational protein folding

description: The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis.


TSN1_HUMAN Tetraspanin-1 (sprot)

A tetraspanin-1 that is encoded in the genome of human.


TSN2_HUMAN Tetraspanin-2 (sprot)

A tetraspanin-2 that is encoded in the genome of human.


oligodendrocyte differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.


axon development

description: The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation).


myelin sheath

description: An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.


TSN3_HUMAN Tetraspanin-3 (sprot)

A tetraspanin-3 that is encoded in the genome of human.


name: AP180_HUMAN Clathrin coat assembly protein AP180 (sprot)

description: A clathrin coat assembly protein AP180 that is encoded in the genome of human.


name: regulation of clathrin-dependent endocytosis

description: Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis.


name: EXOC3_HUMAN Exocyst complex component 3 (sprot)

description: An exocyst complex component 3 that is encoded in the genome of human.


name: UD19_HUMAN UDP-glucuronosyltransferase 1A9 (sprot)

description: A UDP-glucuronosyltransferase 1A9 that is encoded in the genome of human.


flavone metabolic process

description: The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone).


cellular glucuronidation

description: The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor.


flavonoid glucuronidation

description: The modification of a flavonoid by the conjugation of glucuronic acid. The resultant flavonoid glucuronosides are often much more water-soluble than the precursor.


xenobiotic glucuronidation

description: The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion.


name: PDE8A_HUMAN High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (sprot)

description: A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A that is encoded in the genome of human.


protein kinase activator activity

description: Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.


cAMP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).


name: KLH41_HUMAN Kelch-like protein 41 (sprot)

description: A kelch-like protein 41 that is encoded in the genome of human.


myofibril assembly

description: Formation of myofibrils, the repeating units of striated muscle.


pseudopodium assembly

description: The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane.


regulation of myoblast differentiation

description: Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


name: LMX1B_HUMAN LIM homeobox transcription factor 1-beta (sprot)

description: A LIM homeobox transcription factor 1-beta that is encoded in the genome of human.


PLIN3_HUMAN Perilipin-3 (sprot)

A perilipin-3 that is encoded in the genome of human.


lipid droplet disassembly

description: The disaggregation of a lipid particle into its constituent components.


name: FCMR_HUMAN Immunoglobulin mu Fc receptor (sprot)

description: An immunoglobulin mu Fc receptor that is encoded in the genome of human.


polymeric immunoglobulin binding

description: Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes.


IgM binding

description: Binding to an immunoglobulin of the IgM isotype.


high-affinity IgM receptor activity

description: Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: immunoglobulin transcytosis in epithelial cells

description: The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other.


name: humoral immune response mediated by circulating immunoglobulin

description: An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.


Fc receptor signaling pathway

description: The series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.


name: regulation of B cell receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.


name: Fc receptor-mediated immune complex endocytosis

description: An endocytosis process mediated by the Fc receptor for the purpose of delivery of antigen-bound immunoglobulin to an intracellular compartment where the antigen can be processed and loaded onto MHC molecules. This process selectively targets antigens for presentation by MHC class II or cross-presentation by MHC class I.


name: MOT2_HUMAN Monocarboxylate transporter 2 (sprot)

description: A monocarboxylate transporter 2 that is encoded in the genome of human.


name: pyruvate secondary active transmembrane transporter activity

description: Enables the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.


name: lactate transmembrane transporter activity

description: Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.


name: RAD1_HUMAN Cell cycle checkpoint protein RAD1 (sprot)

description: A cell cycle checkpoint protein RAD1 that is encoded in the genome of human.


name: double-stranded DNA 3'-5' DNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule.


name: meiotic recombination checkpoint signaling

description: A signaling process that contributes to a meiotic recombination checkpoint, that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes.


checkpoint clamp complex

description: Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage.


name: REV3L_HUMAN DNA polymerase zeta catalytic subunit (sprot)

description: A DNA polymerase zeta catalytic subunit that is encoded in the genome of human.


error-prone translesion synthesis

description: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.


zeta DNA polymerase complex

description: A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer.


name: JAK2_HUMAN Tyrosine-protein kinase JAK2 (sprot)

description: A tyrosine-protein kinase JAK2 that is encoded in the genome of human.


name: positive regulation of SMAD protein signal transduction

description: Any process that increases the rate, frequency or extent of SMAD protein signal transduction.


interleukin-12 receptor binding

description: Binding to an interleukin-12 receptor.


type 1 angiotensin receptor binding

description: Binding to a type 1 angiotensin receptor.


histone H3Y41 kinase activity

description: Catalysis of the reaction: histone H3-tyrosine (position 41) + ATP = histone H3-phosphotyrosine (position 41) + ADP. This reaction is the addition of a phosphate group to the tyrosine residue at position 41 of histone H3.


phosphatidylinositol 3-kinase binding

description: Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.


insulin receptor substrate binding

description: Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.


peptide hormone receptor binding

description: Binding to a receptor for a peptide hormone.


name: enzyme-linked receptor protein signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription.


response to amine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.


peptidyl-tyrosine phosphorylation

description: The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.


axon regeneration

description: The regrowth of axons following their loss or damage.


name: nuclear receptor-mediated mineralocorticoid signaling pathway

description: A nuclear receptor-mediated signaling pathway initiated by a mineralocorticoid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


name: positive regulation of natural killer cell proliferation

description: Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation.


name: symbiont-induced defense-related programmed cell death

description: Cell death resulting from activation of endogenous cellular processes after interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). This can be triggered by direct interaction with the organism, for example, contact with penetrating hyphae of a fungus; or an indirect interaction such as symbiont-secreted molecules.


description: The series of molecular signals initiated by interleukin-12 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


cellular response to interleukin-3

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus.


description: The series of molecular signals initiated by interleukin-5 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


collagen-activated signaling pathway

description: The series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


description: The series of molecular signals initiated by interleukin-3 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: granulocyte-macrophage colony-stimulating factor signaling pathway

description: The series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors.


name: positive regulation of tyrosine phosphorylation of STAT protein

description: Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


activation of Janus kinase activity

description: The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.


name: regulation of nitric oxide biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.


name: regulation of receptor signaling pathway via JAK-STAT

description: Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT.


name: positive regulation of receptor signaling pathway via JAK-STAT

description: Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.


name: positive regulation of NK T cell proliferation

description: Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation.


name: type II interferon-mediated signaling pathway

description: The series of molecular signals initiated by interferon-gamma binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.


name: growth hormone receptor signaling pathway via JAK-STAT

description: The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.


name: positive regulation of growth hormone receptor signaling pathway

description: Any process that increases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.


mammary gland epithelium development

description: The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.


name: positive regulation of leukocyte proliferation

description: Any process that activates or increases the frequency, rate or extent of leukocyte proliferation.


description: The series of molecular signals initiated by interleukin-35 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

description: Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway.


name: positive regulation of growth factor dependent skeletal muscle satellite cell proliferation

description: Any process that activates or increases the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta.


name: positive regulation of epithelial cell apoptotic process

description: Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process.


name: regulation of postsynapse to nucleus signaling pathway

description: Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway.


name: positive regulation of T-helper 17 type immune response

description: Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response.


extrinsic component of plasma membrane

description: The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


name: granulocyte macrophage colony-stimulating factor receptor complex

description: The heterodimeric receptor for granulocyte macrophage colony-stimulating factor.


interleukin-12 receptor complex

description: A protein complex that binds interleukin-12 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits.


interleukin-23 receptor complex

description: A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits.


name: MAFK_HUMAN Transcription factor MafK (sprot)

description: A transcription factor MafK that is encoded in the genome of human.


CST8_HUMAN Cystatin-8 (sprot)

A cystatin-8 that is encoded in the genome of human.


name: ANM3_HUMAN Protein arginine N-methyltransferase 3 (sprot)

description: A protein arginine N-methyltransferase 3 that is encoded in the genome of human.


name: protein-arginine omega-N monomethyltransferase activity

description: Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine.


name: protein-arginine omega-N asymmetric methyltransferase activity

description: Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues.


name: negative regulation of retinoic acid biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid biosynthetic process.


MUSC_HUMAN Musculin (sprot)

A musculin that is encoded in the genome of human.


cardiac conduction system development

description: The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.


name: PEX10_HUMAN Peroxisome biogenesis factor 10 (sprot)

description: A peroxisome biogenesis factor 10 that is encoded in the genome of human.


name: IMA7_HUMAN Importin subunit alpha-7 (sprot)

description: An importin subunit alpha-7 that is encoded in the genome of human.


name: entry of viral genome into host nucleus through nuclear pore complex via importin

description: Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery.


positive regulation of viral life cycle

description: Any process that activates or increases the frequency, rate or extent of viral life cycle.


name: SRPX2_HUMAN Sushi repeat-containing protein SRPX2 (sprot)

description: A sushi repeat-containing protein SRPX2 that is encoded in the genome of human.


hepatocyte growth factor binding

description: Binding to a hepatocyte growth factor.


cell motility

description: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.


name: YPEL1_HUMAN Protein yippee-like 1 (sprot)

description: A protein yippee-like 1 that is encoded in the genome of human.


name: UGDH_HUMAN UDP-glucose 6-dehydrogenase (sprot)

description: A UDP-glucose 6-dehydrogenase that is encoded in the genome of human.


UDP-glucose 6-dehydrogenase activity

description: Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate.


UDP-glucuronate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate.


name: chondroitin sulfate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.


protein hexamerization

description: The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.


name: TPST2_HUMAN Protein-tyrosine sulfotransferase 2 (sprot)

description: A protein-tyrosine sulfotransferase 2 that is encoded in the genome of human.


peptidyl-tyrosine sulfation

description: The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine.


name: ABCC9_HUMAN ATP-binding cassette sub-family C member 9 (sprot)

description: An ATP-binding cassette sub-family C member 9 that is encoded in the genome of human.


name: ATP-activated inward rectifier potassium channel activity

description: Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.


sulfonylurea receptor activity

description: Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: ATPase-coupled monoatomic cation transmembrane transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).


cardiac conduction

description: Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.


cardiac muscle cell contraction

description: The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell.


name: potassium ion import across plasma membrane

description: The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.


inward rectifying potassium channel

description: A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity.


name: potassium ion-transporting ATPase complex

description: Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex.


LPXN_HUMAN Leupaxin (sprot)

A leupaxin that is encoded in the genome of human.


name: negative regulation of B cell receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.


CTND1_HUMAN Catenin delta-1 (sprot)

A catenin delta-1 that is encoded in the genome of human.


cell-cell adhesion mediated by cadherin

description: The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.


zonula adherens

description: A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.


name: presynaptic active zone cytoplasmic component

description: A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles.


catenin complex

description: Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton.


name: NCKX1_HUMAN Sodium/potassium/calcium exchanger 1 (sprot)

description: A sodium/potassium/calcium exchanger 1 that is encoded in the genome of human.


name: calcium, potassium:sodium antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).


response to light intensity

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus.


name: calcium ion import across plasma membrane

description: The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol.


outer membrane

description: The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.


name: ICMT_HUMAN Protein-S-isoprenylcysteine O-methyltransferase (sprot)

description: A protein-S-isoprenylcysteine O-methyltransferase that is encoded in the genome of human.


name: protein C-terminal carboxyl O-methyltransferase activity

description: Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein.


name: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.


C-terminal protein methylation

description: The methylation of the C-terminal amino acid of a protein.


description: The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine.


description: The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt.


name: CC14B_HUMAN Dual specificity protein phosphatase CDC14B (sprot)

description: A dual specificity protein phosphatase CDC14B that is encoded in the genome of human.


name: MAGC1_HUMAN Melanoma-associated antigen C1 (sprot)

description: A melanoma-associated antigen C1 that is encoded in the genome of human.


name: PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2 (sprot)

description: An 85/88 kDa calcium-independent phospholipase A2 that is encoded in the genome of human.


lysophospholipase activity

description: Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine.


serine hydrolase activity

description: Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


name: calcium-independent phospholipase A2 activity

description: Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+.


phosphatidyl phospholipase B activity

description: Catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate.


antibacterial humoral response

description: An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.


cardiolipin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.


cardiolipin acyl-chain remodeling

description: Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids.


description: The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.


name: platelet activating factor metabolic process

description: The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli.


name: EIF1B_HUMAN Eukaryotic translation initiation factor 1b (sprot)

description: A eukaryotic translation initiation factor 1b that is encoded in the genome of human.


name: HCN1_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (sprot)

description: A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is encoded in the genome of human.


name: intracellularly cAMP-activated cation channel activity

description: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts.


voltage-gated sodium channel activity

description: Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential

description: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential.


retinal cone cell development

description: Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision.


name: general adaptation syndrome, behavioral process

description: The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus.


HCN channel complex

description: A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart.


SNX2_HUMAN Sorting nexin-2 (sprot)

A sorting nexin-2 that is encoded in the genome of human.


insulin receptor binding

description: Binding to an insulin receptor.


leptin receptor binding

description: Binding to a leptin receptor.


lamellipodium morphogenesis

description: A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized.


retromer, tubulation complex

description: The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodeling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6.


name: GALR3_HUMAN Galanin receptor type 3 (sprot)

description: A galanin receptor type 3 that is encoded in the genome of human.


name: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

description: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.


name: CYTIP_HUMAN Cytohesin-interacting protein (sprot)

description: A cytohesin-interacting protein that is encoded in the genome of human.


name: HPGDS_HUMAN Hematopoietic prostaglandin D synthase (sprot)

description: A glutathione-requiring prostaglandin D synthase that is encoded in the genome of human.


name: negative regulation of male germ cell proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation.


name: DPM1_HUMAN Dolichol-phosphate mannosyltransferase subunit 1 (sprot)

description: A dolichol-phosphate mannosyltransferase subunit 1 that is encoded in the genome of human.


GPI anchor biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.


dolichol metabolic process

description: The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units.


description: Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.


description: Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.


alcohol binding

description: Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group.


name: dolichol-linked oligosaccharide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P.


name: protein N-linked glycosylation via asparagine

description: The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.


protein mannosylation

description: The addition of a mannose residue to a protein acceptor molecule.


description: A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively.


name: USO1_HUMAN General vesicular transport factor p115 (sprot)

description: A general vesicular transport factor p115 that is encoded in the genome of human.


secretory granule localization

description: Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell.


vesicle fusion with Golgi apparatus

description: The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi.


name: regulation of cellular response to insulin stimulus

description: Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus.


name: Z354A_HUMAN Zinc finger protein 354A (sprot)

description: A zinc finger protein 354A that is encoded in the genome of human.


name: FMO6_HUMAN Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (sprot)


hypotaurine dehydrogenase activity

description: Catalysis of the reaction: H+ + hypotaurine + NADPH + O2 = H2O + NADP+ + taurine.


name: S19A2_HUMAN Thiamine transporter 1 (sprot)

description: A thiamine transporter 1 that is encoded in the genome of human.


name: folic acid transmembrane transporter activity

description: Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.


name: thiamine diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.


folic acid transport

description: The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.


pyridoxine transport

description: The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.


name: thiamine-containing compound metabolic process

description: The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it.


name: RT14_HUMAN Small ribosomal subunit protein uS14m (sprot)

description: A small ribosomal subunit protein uS14m that is encoded in the genome of human.


name: TOM1_HUMAN Target of Myb1 membrane trafficking protein (sprot)

description: A target of Myb1 membrane trafficking protein that is encoded in the genome of human.


name: polyubiquitin modification-dependent protein binding

description: Binding to a protein upon poly-ubiquitination of the target protein.


clathrin heavy chain binding

description: Binding to a clathrin heavy chain.


myosin VI binding

description: Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments.


substrate localization to autophagosome

description: The localization process by which an autophagic substrate is delivered to a forming autophagosome.


autophagosome-lysosome fusion

description: The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome.


regulation of endosome organization

description: Any process that modulates the frequency, rate or extent of endosome organization.


name: TBX19_HUMAN T-box transcription factor TBX19 (sprot)

description: A T-box transcription factor TBX19 that is encoded in the genome of human.


name: PRA10_HUMAN PRAME family member 10 (sprot)

description: A PRAME family member 10 that is encoded in the genome of human.


name: PRAM4_HUMAN PRAME family member 4 (sprot)

description: A PRAME family member 4 that is encoded in the genome of human.


name: PRAM2_HUMAN PRAME family member 2 (sprot)

description: A PRAME family member 2 that is encoded in the genome of human.


name: HNRC1_HUMAN Heterogeneous nuclear ribonucleoprotein C-like 1 (sprot)

description: A heterogeneous nuclear ribonucleoprotein C-like 1 that is encoded in the genome of human.


name: PRA11_HUMAN PRAME family member 11 (sprot)

description: A PRAME family member 11 that is encoded in the genome of human.


name: H2B1K_HUMAN Histone H2B type 1-K (sprot)

description: A histone H2B type 1-K that is encoded in the genome of human.


innate immune response in mucosa

description: Any process of the innate immune response that takes place in the mucosal tissues.


name: F262_HUMAN 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (sprot)

description: A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 that is encoded in the genome of human.


6-phosphofructo-2-kinase activity

description: Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H+.


fructose metabolic process

description: The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.


glucose catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose.


lactate metabolic process

description: The chemical reactions and pathways involving lactate, the anion of lactic acid.


carbohydrate phosphorylation

description: The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y.


name: CCD22_HUMAN Coiled-coil domain-containing protein 22 (sprot)

description: A coiled-coil domain-containing protein 22 that is encoded in the genome of human.


cytoplasmic sequestering of NF-kappaB

description: The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.


name: PQBP1_HUMAN Polyglutamine-binding protein 1 (sprot)

description: A polyglutamine-binding protein 1 that is encoded in the genome of human.


name: alternative mRNA splicing, via spliceosome

description: The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.


neuronal ribonucleoprotein granule

description: A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.


name: PAGE4_HUMAN P antigen family member 4 (sprot)

description: A P antigen family member 4 that is encoded in the genome of human.


name: TI17B_HUMAN Mitochondrial import inner membrane translocase subunit Tim17-B (sprot)

description: A mitochondrial import inner membrane translocase subunit Tim17-B that is encoded in the genome of human.


name: PRAF2_HUMAN PRA1 family protein 2 (sprot)

description: A PRA1 family protein 2 that is encoded in the genome of human.


name: DKC1_HUMAN H/ACA ribonucleoprotein complex subunit DKC1 (sprot)

description: An H/ACA ribonucleoprotein complex catalytic subunit that is encoded in the genome of human.


pseudouridine synthase activity

description: Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.


box H/ACA snoRNA binding

description: Binding to a box H/ACA small nucleolar RNA.


name: enzyme-directed rRNA pseudouridine synthesis

description: The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA.


scaRNA localization to Cajal body

description: A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body.


telomerase RNA stabilization

description: Prevention of degradation of telomerase RNA (TERC) molecules.


name: positive regulation of establishment of protein localization to telomere

description: Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere.


name: positive regulation of protein localization to Cajal body

description: Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body.


name: regulation of telomerase RNA localization to Cajal body

description: Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body.


name: positive regulation of telomerase RNA localization to Cajal body

description: Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body.


box H/ACA snoRNP complex

description: A box H/ACA small nucleolar ribonucleoprotein complex located in the nucleolus that catalyzes pseudouridylation of ribosomal RNA residues. The complex is composed of four different core proteins that assemble onto a H/ACA guide RNA scaffold that identifies specific uridines in rRNA for modification during ribosome synthesis.


box H/ACA scaRNP complex

description: A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs.


box H/ACA telomerase RNP complex

description: A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell.


name: CAC1F_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1F (sprot)

description: A voltage-dependent L-type calcium channel subunit alpha-1F that is encoded in the genome of human.


name: IF2P_HUMAN Eukaryotic translation initiation factor 5B (sprot)

description: A eukaryotic translation initiation factor 5B that is encoded in the genome of human.


ribosome assembly

description: The aggregation, arrangement and bonding together of the mature ribosome and of its subunits.


name: ZG16_HUMAN Zymogen granule membrane protein 16 (sprot)

description: A zymogen granule membrane protein 16 that is encoded in the genome of human.


suppression of symbiont entry into host

description: Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction.


mucus layer

description: An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon or secreted into fluids such as saliva. Mucus is a viscous slimy secretion consisting of mucins (i.e. highly glycosylated mucin proteins) and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes.


name: TRI13_HUMAN E3 ubiquitin-protein ligase TRIM13 (sprot)

description: An E3 ubiquitin-protein ligase TRIM13 that is encoded in the genome of human.


ubiquitin-like protein ligase activity

description: Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate.


name: negative regulation of viral transcription

description: Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription.


suppression of viral release by host

description: A process in which a host organism stops, prevents or reduces the frequency, rate or extent of the release of a virus with which it is infected, from its cells.


name: GAS7_HUMAN Growth arrest-specific protein 7 (sprot)

description: A growth arrest-specific protein 7 that is encoded in the genome of human.


name: EDF1_HUMAN Endothelial differentiation-related factor 1 (sprot)

description: An endothelial differentiation-related factor 1 that is encoded in the genome of human.


name: TFIID-class transcription factor complex binding

description: Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


name: KIN17_HUMAN DNA/RNA-binding protein KIN17 (sprot)

description: A DNA/RNA-binding protein KIN17 that is encoded in the genome of human.


name: DIAP2_HUMAN Protein diaphanous homolog 2 (sprot)

description: A protein diaphanous homolog 2 that is encoded in the genome of human.


name: SH21A_HUMAN SH2 domain-containing protein 1A (sprot)

description: An SH2 domain-containing protein 1A that is encoded in the genome of human.


humoral immune response

description: An immune response mediated through a body fluid.


name: natural killer cell mediated cytotoxicity

description: The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.


name: negative regulation of T cell receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.