receptor ligand inhibitor activity

description: Binds to and decreases the activity of the ligand of a signaling receptor.


virion attachment to host cell

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection.


cellular response to interleukin-4

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.


HSP90-CDC37 chaperone complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins.


name: SRPRA_HUMAN Signal recognition particle receptor subunit alpha (sprot)

description: A signal recognition particle receptor subunit alpha that is encoded in the genome of human.


name: cotranslational protein targeting to membrane

description: The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria.


name: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition

description: The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting.


name: signal recognition particle receptor complex

description: A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex.


name: ASNS_HUMAN Asparagine synthetase [glutamine-hydrolyzing] (sprot)

description: An asparagine synthetase [glutamine-hydrolyzing] that is encoded in the genome of human.


asparagine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid.


name: asparagine synthase (glutamine-hydrolyzing) activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.


L-asparagine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid.


ELNE_HUMAN Neutrophil elastase (sprot)

A neutrophil elastase that is encoded in the genome of human.


name: biosynthetic process of antibacterial peptides active against Gram-negative bacteria

description: The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria.


negative regulation of chemotaxis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.


neutrophil-mediated killing of fungus

description: The directed killing of a fungal cell by a neutrophil.


SYPH_HUMAN Synaptophysin (sprot)

A synaptophysin that is encoded in the genome of human.


name: regulation of opioid receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of opioid receptor signaling pathway.


name: MMP2_HUMAN 72 kDa type IV collagenase (sprot)

description: A 72 kDa type IV collagenase that is encoded in the genome of human.


macrophage chemotaxis

description: The movement of a macrophage in response to an external stimulus.


name: positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

description: Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway.


MMP3_HUMAN Stromelysin-1 (sprot)

A stromelysin-1 that is encoded in the genome of human.


name: GSTA1_HUMAN Glutathione S-transferase A1 (sprot)

description: A glutathione S-transferase A1 that is encoded in the genome of human.


steroid delta-isomerase activity

description: Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid.


name: glutathione derivative biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glutathione derivative.


name: SODE_HUMAN Extracellular superoxide dismutase [Cu-Zn] (sprot)

description: An extracellular superoxide dismutase [Cu-Zn] that is encoded in the genome of human.


CATG_HUMAN Cathepsin G (sprot)

A cathepsin G that is encoded in the genome of human.


name: neutrophil-mediated killing of gram-positive bacterium

description: The directed killing of a gram-positive bacterium by a neutrophil.


biofilm matrix disassembly

description: A process that results in the disassembly of a biofilm matrix.


name: ADH4_HUMAN All-trans-retinol dehydrogenase [NAD(+)] ADH4 (sprot)

description: An all-trans-retinol dehydrogenase [NAD(+)] ADH4 that is encoded in the genome of human.


all-trans retinal binding

description: Binding to all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A.


name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.


name: benzaldehyde dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+.


ethanol metabolic process

description: The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.


fatty acid omega-oxidation

description: A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation.


alcohol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.


name: HEM3_HUMAN Porphobilinogen deaminase (sprot)

description: A porphobilinogen deaminase that is encoded in the genome of human.


hydroxymethylbilane synthase activity

description: Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4.


NEP_HUMAN Neprilysin (sprot)

A neprilysin that is encoded in the genome of human.


exopeptidase activity

description: Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.


oligopeptidase activity

description: Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds.


peptide metabolic process

description: The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.


substance P catabolic process

description: The chemical reactions and pathways resulting in the breakdown of the neuropeptide substance P.


bradykinin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin.


hormone catabolic process

description: The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.


creatinine metabolic process

description: The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine.


neuropeptide processing

description: Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a neuropeptide precursor. Processing leads to the attainment of the full functional capacity of the neuropeptide.


neuron projection terminus

description: The specialized, terminal region of a neuron projection such as an axon or a dendrite.


name: INHBA_HUMAN Inhibin beta A chain (sprot)

description: An activin/inhibin beta A chain that is encoded in the genome of human.


type II activin receptor binding

description: Binding to a type II activin receptor.


name: striatal medium spiny neuron differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum.


progesterone secretion

description: The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta.


name: regulation of follicle-stimulating hormone secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone.


positive regulation of ovulation

description: Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.


cardiac fibroblast cell development

description: The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules.


name: cellular response to oxygen-glucose deprivation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose.


activin A complex

description: A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A).


MGP_HUMAN Matrix Gla protein (sprot)

A matrix Gla protein that is encoded in the genome of human.


ITA2B_HUMAN Integrin alpha-IIb (sprot)

An integrin alpha-IIb that is encoded in the genome of human.


name: positive regulation of leukocyte migration

description: Any process that activates or increases the frequency, rate, or extent of leukocyte migration.


APOA_HUMAN Apolipoprotein(a) (sprot)

An apolipoprotein(a) that is encoded in the genome of human.


plasma lipoprotein particle

description: A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.


name: ODPA_HUMAN Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (sprot)

description: A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial that is encoded in the genome of human.


name: pyruvate dehydrogenase (acetyl-transferring) activity

description: Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.


PLEK_HUMAN Pleckstrin (sprot)

A pleckstrin that is encoded in the genome of human.


name: negative regulation of inositol phosphate biosynthetic process

description: Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.


name: positive regulation of inositol-polyphosphate 5-phosphatase activity

description: Any process that increases the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.


name: phospholipase C-inhibiting G protein-coupled receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A G protein-coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG).


name: positive regulation of actin filament bundle assembly

description: Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.


name: negative regulation of calcium-mediated signaling

description: Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling.


regulation of cell diameter

description: Any process that modulates the diameter of a cell, the length of a line segment that crosses through the center of a circular section through a cell.


protein secretion by platelet

description: The regulated release of proteins by a platelet or group of platelets.


name: CD14_HUMAN Monocyte differentiation antigen CD14 (sprot)

description: A CD14 molecule that is encoded in the genome of human.


opsonin receptor activity

description: Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


lipoteichoic acid binding

description: Binding to lipoteichoic acid.


name: CO4A2_HUMAN Collagen alpha-2(IV) chain (sprot)

description: A collagen alpha-2(IV) chain that is encoded in the genome of human.


name: CY1_HUMAN Cytochrome c1, heme protein, mitochondrial (sprot)

description: A cytochrome c1, heme protein, mitochondrial that is encoded in the genome of human.


name: PTPRC_HUMAN Receptor-type tyrosine-protein phosphatase C (sprot)

description: A receptor-type tyrosine-protein phosphatase C that is encoded in the genome of human.


name: negative regulation of T cell mediated cytotoxicity

description: Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.


name: negative regulation of protein autophosphorylation

description: Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.


gamma-delta T cell differentiation

description: The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex.


name: positive regulation of gamma-delta T cell differentiation

description: Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation.


alpha-beta T cell proliferation

description: The expansion of an alpha-beta T cell population by cell division.


name: positive regulation of alpha-beta T cell proliferation

description: Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.


name: regulation of T cell receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.


name: positive regulation of antigen receptor-mediated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.


name: regulation of protein tyrosine kinase activity

description: Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity.


DN2 thymocyte differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a DN2 thymocyte. A DN2 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25-.


name: positive regulation of hematopoietic stem cell migration

description: Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration.


name: RU2B_HUMAN U2 small nuclear ribonucleoprotein B'' (sprot)

description: A U2 small nuclear ribonucleoprotein B'' that is encoded in the genome of human.


name: MET_HUMAN Hepatocyte growth factor receptor (sprot)

description: A hepatocyte growth factor receptor that is encoded in the genome of human.


name: negative regulation of thrombin-activated receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.


name: negative regulation of hydrogen peroxide-mediated programmed cell death

description: Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death.


name: negative regulation of guanyl-nucleotide exchange factor activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity.


TRFM_HUMAN Melanotransferrin (sprot)

A melanotransferrin that is encoded in the genome of human.


name: ADRB1_HUMAN Beta-1 adrenergic receptor (sprot)

description: A beta-1 adrenergic receptor that is encoded in the genome of human.


beta-adrenergic receptor activity

description: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein.


beta1-adrenergic receptor activity

description: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors.


alpha-2A adrenergic receptor binding

description: Binding to an alpha-2A adrenergic receptor.


name: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

description: A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential.


name: positive regulation of heart rate by epinephrine-norepinephrine

description: The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction.


name: positive regulation of the force of heart contraction by epinephrine-norepinephrine

description: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings.


fear response

description: The response of an organism to a perceived external threat.


MYL3_HUMAN Myosin light chain 3 (sprot)

A myosin light chain 3 that is encoded in the genome of human.


myosin II heavy chain binding

description: Binding to a heavy chain of a myosin II complex.


name: regulation of striated muscle contraction

description: Any process that modulates the frequency, rate or extent of striated muscle contraction.


CFAH_HUMAN Complement factor H (sprot)

A complement factor H that is encoded in the genome of human.


name: regulation of complement activation, alternative pathway

description: Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation.


symbiont cell surface

description: The cell surface of a secondary, endosymbiont organism with which the first organism is interacting. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.


name: FGF4_HUMAN Fibroblast growth factor 4 (sprot)

description: A fibroblast growth factor 4 that is encoded in the genome of human.


name: RU17_HUMAN U1 small nuclear ribonucleoprotein 70 kDa (sprot)

description: A U1 small nuclear ribonucleoprotein 70 kDa that is encoded in the genome of human.


U1 snRNA binding

description: Binding to a U1 small nuclear RNA (U1 snRNA).


name: negative regulation of protein refolding

description: Any process that decreases the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.


name: negative regulation of chaperone-mediated autophagy

description: Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated autophagy.


U1 snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U1, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U1 snRNP, most of which remain associated with the U1 snRNA both while the U1 snRNP is free or assembled into a series of spliceosomal complexes.


name: HCK_HUMAN Tyrosine-protein kinase HCK (sprot)

description: A tyrosine-protein kinase HCK that is encoded in the genome of human.


name: leukocyte migration involved in immune response

description: The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response.


name: innate immune response-activating signaling pathway

description: The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an innate immune response.


leukocyte degranulation

description: The regulated exocytosis of secretory granules by a leukocyte.


respiratory burst after phagocytosis

description: A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity.


name: FCG3A_HUMAN Low affinity immunoglobulin gamma Fc region receptor III-A (sprot)

description: A low affinity immunoglobulin gamma Fc region receptor III-A that is encoded in the genome of human.


low-affinity IgG receptor activity

description: Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


immune receptor activity

description: Receiving a signal and transmitting it in a cell to initiate an immune response.


Fc-gamma receptor III complex

description: A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG.


ITA5_HUMAN Integrin alpha-5 (sprot)

An integrin alpha-5 that is encoded in the genome of human.


name: NFIC_HUMAN Nuclear factor 1 C-type (sprot)

description: A nuclear factor 1 C-type that is encoded in the genome of human.


VIME_HUMAN Vimentin (sprot)

A vimentin that is encoded in the genome of human.


regulation of mRNA stability

description: Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.


CP3A4_HUMAN Cytochrome P450 3A4 (sprot)

A cytochrome P450 3A4 that is encoded in the genome of human.


steroid hydroxylase activity

description: Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.


vitamin D3 25-hydroxylase activity

description: Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O.


quinine 3-monooxygenase activity

description: Catalysis of the reaction: H+ + NADPH + O2 + quinine = 3-hydroxyquinine + H2O + NADP+.


description: Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O.


name: 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity

description: Catatlysis of the reaction: calcitriol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin].


anandamide 8,9 epoxidase activity

description: Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase].


anandamide 11,12 epoxidase activity

description: Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase].


anandamide 14,15 epoxidase activity

description: Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase].


description: Catalysis of the reaction: 1,8-cineole + NADPH + H+ + O2 = 2-exo-hydroxy-1,8-cineole + NADP + H2O.


alkaloid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases).


vitamin D catabolic process

description: The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).


name: CP21A_HUMAN Steroid 21-hydroxylase (sprot)

description: A steroid 21-hydroxylase that is encoded in the genome of human.


steroid 21-monooxygenase activity

description: Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O.


description: Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


progesterone 21-hydroxylase activity

description: Catalysis of the reaction: O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


mineralocorticoid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.


A2AP_HUMAN Alpha-2-antiplasmin (sprot)

An alpha-2-antiplasmin that is encoded in the genome of human.


IL3_HUMAN Interleukin-3 (sprot)

An interleukin-3 that is encoded in the genome of human.


interleukin-3 receptor binding

description: Binding to an interleukin-3 receptor.


name: RS17_HUMAN Small ribosomal subunit protein eS17 (sprot)

description: A small ribosomal subunit protein eS17 that is encoded in the genome of human.


ribosome

description: An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.


name: FA7_HUMAN Coagulation factor VII (sprot)

description: A coagulation factor VII that is encoded in the genome of human.


name: positive regulation of platelet-derived growth factor receptor signaling pathway

description: Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.


response to genistein

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus.


name: positive regulation of positive chemotaxis

description: Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.


response to Thyroid stimulating hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus.


description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus.


response to astaxanthin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus.


name: response to thyrotropin-releasing hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.


serine-type peptidase complex

description: A protein complex which is capable of serine-type peptidase activity.


name: K1C19_HUMAN Keratin, type I cytoskeletal 19 (sprot)

description: A keratin, type I cytoskeletal 19 that is encoded in the genome of human.


terminal web

description: An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells.


name: K2C7_HUMAN Keratin, type II cytoskeletal 7 (sprot)

description: A keratin, type II cytoskeletal 7 that is encoded in the genome of human.


name: GNAI3_HUMAN Guanine nucleotide-binding protein G(i) subunit alpha-3 (sprot)

description: A guanine nucleotide-binding protein G(i) subunit alpha-3 that is encoded in the genome of human.


ANXA5_HUMAN Annexin A5 (sprot)

An annexin A5 that is encoded in the genome of human.


endothelial microparticle

description: A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell.


name: K1C16_HUMAN Keratin, type I cytoskeletal 16 (sprot)

description: A keratin, type I cytoskeletal 16 that is encoded in the genome of human.


name: IBP1_HUMAN Insulin-like growth factor-binding protein 1 (sprot)

description: An insulin-like growth factor-binding protein 1 that is encoded in the genome of human.


STS_HUMAN Steryl-sulfatase (sprot)

A steryl-sulfatase that is encoded in the genome of human.


steryl-sulfatase activity

description: Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.


sulfuric ester hydrolase activity

description: Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2.


name: CEL3B_HUMAN Chymotrypsin-like elastase family member 3B (sprot)

description: A chymotrypsin-like elastase family member 3B that is encoded in the genome of human.


name: RSSA_HUMAN Small ribosomal subunit protein uS2 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS2 that is encoded in the genome of human.


name: IL6RA_HUMAN Interleukin-6 receptor subunit alpha (sprot)

description: An interleukin-6 receptor subunit alpha that is encoded in the genome of human.


name: ciliary neurotrophic factor receptor activity

description: Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


interleukin-6 receptor activity

description: Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


interleukin-6 binding

description: Binding to interleukin-6.


ciliary neurotrophic factor binding

description: Binding to the cytokine ciliary neurotrophic factor.


description: The series of molecular signals initiated by the binding of interleukin-11 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: ciliary neurotrophic factor-mediated signaling pathway

description: The series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: ciliary neurotrophic factor receptor complex

description: A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR.


name: 5HT1A_HUMAN 5-hydroxytryptamine receptor 1A (sprot)

description: A 5-hydroxytryptamine receptor 1A that is encoded in the genome of human.


name: G protein-coupled serotonin receptor activity

description: Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.


receptor-receptor interaction

description: The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function.


name: adenylate cyclase-inhibiting serotonin receptor signaling pathway

description: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process.


serotonin metabolic process

description: The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.


name: ABHD2_HUMAN Monoacylglycerol lipase ABHD2 (sprot)

description: A monoacylglycerol lipase ABHD2 that is encoded in the genome of human.


acetylesterase activity

description: Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate.


hormone-sensitive lipase activity

description: Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate.


name: ACM5_HUMAN Muscarinic acetylcholine receptor M5 (sprot)

description: A muscarinic acetylcholine receptor M5 that is encoded in the genome of human.


gastric acid secretion

description: The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.


name: regulation of phosphatidylinositol dephosphorylation

description: Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphatidylinositol.


name: ADA2A_HUMAN Alpha-2A adrenergic receptor (sprot)

description: An alpha-2A adrenergic receptor that is encoded in the genome of human.


alpha2-adrenergic receptor activity

description: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein.


alpha-1B adrenergic receptor binding

description: Binding to an alpha-1B adrenergic receptor.


alpha-2C adrenergic receptor binding

description: Binding to an alpha-2C adrenergic receptor.


heterotrimeric G-protein binding

description: Binding to a heterotrimeric G-protein.


epinephrine binding

description: Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.


name: negative regulation of epinephrine secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine.


receptor transactivation

description: The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer.


name: positive regulation of potassium ion transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: negative regulation of calcium ion transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: negative regulation of uterine smooth muscle contraction

description: Any process that decreases the frequency, rate or extent of uterine smooth muscle contraction.


name: adenylate cyclase-inhibiting adrenergic receptor signaling pathway

description: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor, and ending with the regulation of a downstream cellular process.


name: phospholipase C-activating adrenergic receptor signaling pathway

description: A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: ROS1_HUMAN Proto-oncogene tyrosine-protein kinase ROS (sprot)

description: A proto-oncogene tyrosine-protein kinase ROS that is encoded in the genome of human.


name: columnar/cuboidal epithelial cell development

description: The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.


NMB_HUMAN Neuromedin-B (sprot)

A neuromedin-B that is encoded in the genome of human.


sneeze reflex

description: A reflex process that expels air forcibly from the mouth and nose in an explosive, spasmodic involuntary action resulting chiefly from irritation of the nasal mucous membrane.


Leydig cell proliferation

description: The multiplication or reproduction of Leydig cells, resulting in the expansion of a cell population. Leydig cells are interstitial cells located adjacent to the seminiferous tubules in the testis which produce testosterone.


sensory perception of itch

description: A sensory perception which causes the desire or reflex to scratch.


name: positive regulation of testosterone secretion

description: Any process that activates or increases the frequency, rate or extent of testosterone secretion.


CD63_HUMAN CD63 antigen (sprot)

A CD63 molecule that is encoded in the genome of human.


pigment granule maturation

description: Steps required to form a membrane-bounded organelle into a pigment granule containing pigment. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state.


PKHD1_HUMAN Fibrocystin (sprot)

A fibrocystin that is encoded in the genome of human.


regulation of cell-cell adhesion

description: Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.


name: establishment of centrosome localization

description: The directed movement of the centrosome to a specific location.


name: regulation of establishment of planar polarity

description: Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates.


name: regulation of cholangiocyte proliferation

description: Any process that modulates the frequency, rate or extent of cholangiocyte proliferation.


name: RM03_HUMAN Large ribosomal subunit protein uL3m (sprot)

description: A large ribosomal subunit protein uL3m that is encoded in the genome of human.


name: SNRPA_HUMAN U1 small nuclear ribonucleoprotein A (sprot)

description: A U1 small nuclear ribonucleoprotein A that is encoded in the genome of human.


U1 snRNP binding

description: Binding to a U1 small nuclear ribonucleoprotein particle.


name: HXD4_HUMAN Homeobox protein Hox-D4 (sprot)

description: A homeobox protein Hox-D4 that is encoded in the genome of human.


name: HXC4_HUMAN Homeobox protein Hox-C4 (sprot)

description: A homeobox protein Hox-C4 that is encoded in the genome of human.


name: FGF2_HUMAN Fibroblast growth factor 2 (sprot)

description: A fibroblast growth factor 2 that is encoded in the genome of human.


name: regulation of cell migration involved in sprouting angiogenesis

description: Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.


name: regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

description: Any process that modulates the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis.


name: positive regulation of cell fate specification

description: Any process that activates or enables a cell to adopt a specific fate.


chemokine binding

description: Binding to a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.


name: growth factor dependent regulation of skeletal muscle satellite cell proliferation

description: Any process that modulates the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta.


name: positive regulation of inner ear auditory receptor cell differentiation

description: Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation.


name: regulation of retinal cell programmed cell death

description: Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina.


embryonic morphogenesis

description: The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.


name: corticotropin hormone secreting cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin.


name: thyroid-stimulating hormone-secreting cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a thyroid-stimulating hormone-secreting cell. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid-stimulating hormone, thyrotrophin.


name: positive regulation of lens fiber cell differentiation

description: Any process that activates or increases the frequency, rate or extent of lens fiber cell differentiation.


name: positive regulation of neuroepithelial cell differentiation

description: Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation.


name: HXB5_HUMAN Homeobox protein Hox-B5 (sprot)

description: A homeobox protein Hox-B5 that is encoded in the genome of human.


name: PO2F2_HUMAN POU domain, class 2, transcription factor 2 (sprot)

description: A POU domain, class 2, transcription factor 2 that is encoded in the genome of human.


name: CEL3A_HUMAN Chymotrypsin-like elastase family member 3A (sprot)

description: A chymotrypsin-like elastase family member 3A that is encoded in the genome of human.


ENOG_HUMAN Gamma-enolase (sprot)

A gamma-enolase that is encoded in the genome of human.


name: HBAT_HUMAN Hemoglobin subunit theta-1 (sprot)

description: A hemoglobin subunit theta-1 that is encoded in the genome of human.


name: THIK_HUMAN 3-ketoacyl-CoA thiolase, peroxisomal (sprot)

description: A 3-ketoacyl-CoA thiolase, peroxisomal that is encoded in the genome of human.


acetyl-CoA C-acetyltransferase activity

description: Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.


acetyl-CoA C-acyltransferase activity

description: Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.


acetate CoA-transferase activity

description: Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.


palmitoyl-CoA oxidase activity

description: Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide.


description: Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA.


name: very long-chain fatty acid metabolic process

description: The chemical reactions and pathways involving a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.


P3_HUMAN P3 protein (sprot)

A P3 protein that is encoded in the genome of human.


name: SRP19_HUMAN Signal recognition particle 19 kDa protein (sprot)

description: A signal recognition particle 19 kDa protein that is encoded in the genome of human.


name: DOPO_HUMAN Dopamine beta-hydroxylase (sprot)

description: A dopamine beta-hydroxylase that is encoded in the genome of human.


dopamine beta-monooxygenase activity

description: Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O.


leukocyte mediated immunity

description: Any process involved in the carrying out of an immune response by a leukocyte.


homoiothermy

description: Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment.


dopamine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.


behavioral response to ethanol

description: Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.


name: regulation of vascular associated smooth muscle cell proliferation

description: Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation.


name: regulation of extrinsic apoptotic signaling pathway

description: Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway.


chromaffin granule membrane

description: The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.


name: GSTA2_HUMAN Glutathione S-transferase A2 (sprot)

description: A glutathione S-transferase A2 that is encoded in the genome of human.


name: GSTP1_HUMAN Glutathione S-transferase P (sprot)

description: A glutathione S-transferase P that is encoded in the genome of human.


kinase regulator activity

description: Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


S-nitrosoglutathione binding

description: Binding to S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems.


dinitrosyl-iron complex binding

description: Binding to a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO.


nitric oxide binding

description: Binding to nitric oxide (NO).


name: negative regulation of biosynthetic process

description: Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.


nitric oxide storage

description: The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins.


name: negative regulation of leukocyte proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.


TRAF2-GSTP1 complex

description: A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses.


CYTT_HUMAN Cystatin-SA (sprot)

A cystatin-SA that is encoded in the genome of human.


name: RU1C_HUMAN U1 small nuclear ribonucleoprotein C (sprot)

description: A U1 small nuclear ribonucleoprotein C that is encoded in the genome of human.


commitment complex

description: A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript.


U2-type prespliceosome

description: A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.


MMP7_HUMAN Matrilysin (sprot)

A matrilysin that is encoded in the genome of human.


antibacterial peptide secretion

description: The regulated release of an antibacterial peptide from a cell or a tissue.


name: antibacterial peptide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of an antibacterial peptide.


MMP10_HUMAN Stromelysin-2 (sprot)

A stromelysin-2 that is encoded in the genome of human.


CD48_HUMAN CD48 antigen (sprot)

A CD48 molecule that is encoded in the genome of human.


VILI_HUMAN Villin-1 (sprot)

A villin-1 that is encoded in the genome of human.


intestinal D-glucose absorption

description: Uptake of D-glucose into the blood by absorption from the small intestine.


regulation of microvillus length

description: A process that modulates the length of a microvillus.


barbed-end actin filament capping

description: The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.


regulation of actin nucleation

description: Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.


terminal web assembly

description: The aggregation, arrangement and bonding together of a set of components to form a terminal web.


name: regulation of lamellipodium morphogenesis

description: Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis.


name: positive regulation of lamellipodium morphogenesis

description: Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis.


name: GROA_HUMAN Growth-regulated alpha protein (sprot)

description: A growth-regulated alpha protein that is encoded in the genome of human.


LEG1_HUMAN Galectin-1 (sprot)

A galectin-1 that is encoded in the genome of human.


name: DHPR_HUMAN Dihydropteridine reductase (sprot)

description: A dihydropteridine reductase that is encoded in the genome of human.


6,7-dihydropteridine reductase activity

description: Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine.


dihydrobiopterin metabolic process

description: The chemical reactions and pathways involving a dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions.


name: HMGB1_HUMAN High mobility group protein B1 (sprot)

description: A high mobility group protein B1 that is encoded in the genome of human.


C-X-C chemokine binding

description: Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif.


myeloid dendritic cell activation

description: The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


regulation of tolerance induction

description: Any process that modulates the frequency, rate, or extent of tolerance induction.


name: regulation of T cell mediated immune response to tumor cell

description: Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell.


name: negative regulation of RNA polymerase II transcription preinitiation complex assembly

description: Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.


name: regulation of restriction endodeoxyribonuclease activity

description: Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.


V(D)J recombination

description: The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).


name: positive regulation of toll-like receptor 9 signaling pathway

description: Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway.


T-helper 1 cell activation

description: The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


name: negative regulation of CD4-positive, alpha-beta T cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.


T-helper 1 cell differentiation

description: The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.


positive regulation of DNA ligation

description: Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.


name: negative regulation of apoptotic cell clearance

description: Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic cell clearance.


name: STP1_HUMAN Spermatid nuclear transition protein 1 (sprot)

description: A spermatid nuclear transition protein 1 that is encoded in the genome of human.


single strand break repair

description: The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair.


spermatid nucleus differentiation

description: The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization.


spermatid nucleus elongation

description: The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation.


sperm DNA decondensation

description: Unwinding of the condensed nuclear chromatin of an inactive male pronucleus after fertilization.


name: RET1_HUMAN Retinol-binding protein 1 (sprot)

description: A retinol-binding protein 1 that is encoded in the genome of human.


retinoid binding

description: Binding to a retinoid, a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.


all-trans-retinol binding

description: Binding to all-trans-retinol.


PAEP_HUMAN Glycodelin (sprot)

A glycodelin that is encoded in the genome of human.


name: negative regulation of sperm capacitation

description: Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation.


name: regulation of binding of sperm to zona pellucida

description: Any process that modulates the frequency, rate or extent of binding of sperm to the zona pellucida.


name: F16P1_HUMAN Fructose-1,6-bisphosphatase 1 (sprot)

description: A fructose-1,6-bisphosphatase 1 that is encoded in the genome of human.


name: fructose 1,6-bisphosphate 1-phosphatase activity

description: Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.


monosaccharide binding

description: Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.


cellular response to magnesium ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.


cellular hyperosmotic salinity response

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.


cellular hypotonic salinity response

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.


cellular response to raffinose

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus.


name: GNAO_HUMAN Guanine nucleotide-binding protein G(o) subunit alpha (sprot)

description: A guanine nucleotide-binding protein G(o) subunit alpha that is encoded in the genome of human.


SPRC_HUMAN SPARC (sprot)

A SPARC protein that is encoded in the genome of human.


name: GSTM1_HUMAN Glutathione S-transferase Mu 1 (sprot)

description: A glutathione S-transferase mu 1 that is encoded in the genome of human.


nitrobenzene metabolic process

description: The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline.


name: cellular detoxification of nitrogen compound

description: Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.


name: TPM1_HUMAN Tropomyosin alpha-1 chain (sprot)

description: A tropomyosin alpha-1 chain that is encoded in the genome of human.


name: positive regulation of heart rate by epinephrine

description: The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction.


name: negative regulation of vascular associated smooth muscle cell migration

description: Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration.


name: CLCA_HUMAN Clathrin light chain A (sprot)

description: A clathrin light chain A that is encoded in the genome of human.


presynaptic endocytic zone membrane

description: The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release.


clathrin coat

description: A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes.


clathrin complex

description: A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface.


name: CLCB_HUMAN Clathrin light chain B (sprot)

description: A clathrin light chain B that is encoded in the genome of human.


ANXA4_HUMAN Annexin A4 (sprot)

An annexin A4 that is encoded in the genome of human.


name: INHBB_HUMAN Inhibin beta B chain (sprot)

description: An activin/inhibin beta B chain that is encoded in the genome of human.


host cell surface receptor binding

description: Binding to a receptor on the host cell surface.


response to insecticide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.


name: negative regulation of hepatocyte growth factor production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production.


adhesion of symbiont to host cell

description: The attachment of a symbiont to a host cell via adhesion molecules, general stickiness etc., either directly or indirectly.


name: cellular response to Thyroglobulin triiodothyronine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus.


name: CN37_HUMAN 2',3'-cyclic-nucleotide 3'-phosphodiesterase (sprot)

description: A 2',3'-cyclic-nucleotide 3'-phosphodiesterase that is encoded in the genome of human.


description: Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.


cyclic nucleotide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.


WNT2_HUMAN Protein Wnt-2 (sprot)

A protein Wnt-2 that is encoded in the genome of human.


lung induction

description: The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung.


name: positive regulation of epithelial cell proliferation involved in lung morphogenesis

description: Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.


name: epithelial cell proliferation involved in lung morphogenesis

description: The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung.


CD7_HUMAN T-cell antigen CD7 (sprot)

A CD7 molecule that is encoded in the genome of human.


name: IG2R_HUMAN Putative insulin-like growth factor 2-associated protein (sprot)


HMOX1_HUMAN Heme oxygenase 1 (sprot)

A heme oxygenase 1 that is encoded in the genome of human.


heme oxygenase (decyclizing) activity

description: Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase].


heme oxidation

description: The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme.


smooth muscle hyperplasia

description: A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ.


cellular response to cisplatin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus.


name: positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

description: Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis.


name: CSF1_HUMAN Macrophage colony-stimulating factor 1 (sprot)

description: A macrophage colony-stimulating factor 1 that is encoded in the genome of human.


name: macrophage colony-stimulating factor receptor binding

description: Binding to a macrophage colony-stimulating factor receptor.


name: regulation of macrophage derived foam cell differentiation

description: Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.


name: positive regulation of mononuclear cell proliferation

description: Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.


monocyte homeostasis

description: The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.


mammary gland fat development

description: The progression of the mammary gland fat over time, from its formation to the mature structure. The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts.


mammary duct terminal end bud growth

description: The morphogenetic growth of the large, club-shaped terminal end of a mammary gland duct during prepubertal growth and during puberty.


macrophage homeostasis

description: The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.


myeloid leukocyte migration

description: The movement of a myeloid leukocyte within or between different tissues and organs of the body.


name: positive regulation of macrophage colony-stimulating factor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway.


name: positive regulation of microglial cell migration

description: Any process that activates or increases the frequency, rate or extent of microglial cell migration.


name: positive regulation of macrophage migration

description: Any process that activates or increases the frequency, rate or extent of macrophage migration.


name: PGFRB_HUMAN Platelet-derived growth factor receptor beta (sprot)

description: A beta-type platelet-derived growth factor receptor that is encoded in the genome of human.


name: platelet activating factor receptor activity

description: Combining with platelet activating factor to initiate a change in cell activity.


name: platelet-derived growth factor receptor activity

description: Combining with platelet-derived growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.


name: platelet-derived growth factor beta-receptor activity

description: Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity.


name: cell migration involved in vasculogenesis

description: The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes.


name: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

description: The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation.


name: cell migration involved in coronary angiogenesis

description: The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels.


smooth muscle cell chemotaxis

description: The directed movement of a smooth muscle cell in response to an external stimulus.


name: metanephric glomerular mesangial cell proliferation involved in metanephros development

description: The multiplication or reproduction of glomerular mesangial cells in the metanephros, resulting in the expansion of the population.


name: DLDH_HUMAN Dihydrolipoyl dehydrogenase, mitochondrial (sprot)

description: A dihydrolipoyl dehydrogenase, mitochondrial that is encoded in the genome of human.


name: branched-chain alpha-keto acid dehydrogenase activity

description: Catalysis of the reaction: [a branched-chain alpha-keto acid] + CoA + NAD+ = [a branched-chain acyl-CoA] + CO2 + NADH. This enzyme system catalyzes the oxidative decarboxylation of branched-chain alpha-keto acids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs.


dihydrolipoyl dehydrogenase activity

description: Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.


acrosomal matrix

description: A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction.


acetyltransferase complex

description: A protein complex which is capable of acetyltransferase activity.


name: HXB7_HUMAN Homeobox protein Hox-B7 (sprot)

description: A homeobox protein Hox-B7 that is encoded in the genome of human.


name: HXC6_HUMAN Homeobox protein Hox-C6 (sprot)

description: A homeobox protein Hox-C6 that is encoded in the genome of human.


name: ROA1_HUMAN Heterogeneous nuclear ribonucleoprotein A1 (sprot)

description: A heterogeneous nuclear ribonucleoprotein A1 that is encoded in the genome of human.


G-rich strand telomeric DNA binding

description: Binding to G-rich, single-stranded, telomere-associated DNA.


import into nucleus

description: The directed movement of substances into the nucleus.


name: RU2A_HUMAN U2 small nuclear ribonucleoprotein A' (sprot)

description: A U2 small nuclear ribonucleoprotein A' that is encoded in the genome of human.


CATH_HUMAN Pro-cathepsin H (sprot)

A cathepsin H that is encoded in the genome of human.


name: HLA-A specific activating MHC class I receptor activity

description: Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte.


thyroid hormone binding

description: Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland.


name: immune response-regulating signaling pathway

description: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response.


neuropeptide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of neuropeptides. Neuropeptides are signaling peptides that travel across a synaptic junction.


name: positive regulation of peptidase activity

description: Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.


name: dichotomous subdivision of terminal units involved in lung branching

description: The process in which a lung bud bifurcates.


name: COX6C_HUMAN Cytochrome c oxidase subunit 6C (sprot)

description: A cytochrome c oxidase subunit 6C that is encoded in the genome of human.


name: GIP_HUMAN Gastric inhibitory polypeptide (sprot)

description: A gastric inhibitory polypeptide that is encoded in the genome of human.


name: gastric inhibitory polypeptide receptor binding

description: Binding to a gastric inhibitory polypeptide receptor.


name: gastric inhibitory peptide signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by gastric inhibitory peptide (GIP) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: regulation of fatty acid biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils.


SECR_HUMAN Secretin (sprot)

A secretin that is encoded in the genome of human.


digestive hormone activity

description: The action characteristic of a hormone that takes part in the digestion process.


intracellular water homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of water within a cell.


pancreatic juice secretion

description: The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.


name: CD3G_HUMAN T-cell surface glycoprotein CD3 gamma chain (sprot)

description: A CD3 gamma that is encoded in the genome of human.


name: regulation of lymphocyte apoptotic process

description: Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process.


name: TACD2_HUMAN Tumor-associated calcium signal transducer 2 (sprot)

description: A tumor-associated calcium signal transducer 2 that is encoded in the genome of human.


name: negative regulation of branching involved in ureteric bud morphogenesis

description: Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.


negative regulation of ruffle assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly.


name: FGR_HUMAN Tyrosine-protein kinase Fgr (sprot)

description: A tyrosine-protein kinase Fgr that is encoded in the genome of human.


name: negative regulation of natural killer cell activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation.


name: positive regulation of mast cell degranulation

description: Any process that activates or increases the frequency, rate or extent of mast cell degranulation.


name: LPH_HUMAN Lactase/phlorizin hydrolase (sprot)

description: A lactase/phlorizin hydrolase that is encoded in the genome of human.


lactase activity

description: Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose.


beta-glucosidase activity

description: Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.


glycosylceramidase activity

description: Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine.


cellobiose glucosidase activity

description: Catalysis of the reaction: D-cellobiose + H2O = 2 D-glucose.


phlorizin hydrolase activity

description: Catalysis of the reaction: phlorizin + H2O = beta-D-glucose + phloretin.


lactose catabolic process

description: The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose.


quercetin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of quercetin.


cellobiose catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a cellobiose.


name: C1S_HUMAN Complement C1s subcomponent (sprot)

description: A complement C1s subcomponent that is encoded in the genome of human.


name: PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (sprot)

description: A poly [ADP-ribose] polymerase 1 that is encoded in the genome of human.


mitochondrial DNA metabolic process

description: The chemical reactions and pathways involving mitochondrial DNA.


NAD DNA ADP-ribosyltransferase activity

description: Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA.


description: Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein].


name: NAD+- protein-aspartate ADP-ribosyltransferase activity

description: Catalysis of the reaction: L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide.


description: Catalysis of the reaction: L-glutamyl-[protein] + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide.


description: Catalysis of the reaction: L-tyrosyl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein].


description: Catalysis of the reaction: L-histidyl-[protein] + NAD+ = H+ + Nt-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide.


name: NAD+-histone H2BS6 serine ADP-ribosyltransferase activity

description: Catalysis of the transfer of ADP-ribose groups to the serine-6 or an equivalent residue of the N-terminal tail of histone H2B.


name: NAD+-histone H3S10 serine ADP-ribosyltransferase activity

description: Catalysis of the transfer of ADP-ribose groups to the serine-10 or an equivalent residue of the N-terminal tail of histone H3.


name: NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity

description: Catalysis of the transfer of ADP-ribose groups to the glutamate-35 residue of the N-terminal tail of histone H2B (or an equivalent residue).


DNA ADP-ribosylation

description: The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA.


name: regulation of circadian sleep/wake cycle, non-REM sleep

description: Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep.


replication fork reversal

description: Replication fork processing that involves the unwinding of blocked forks to form four-stranded structures resembling Holliday junctions, which are subsequently resolved.


name: positive regulation of single strand break repair

description: Any process that activates or increases the frequency, rate or extent of single strand break repair.


name: positive regulation of myofibroblast differentiation

description: Any process that activates or increases the frequency, rate or extent of myofibroblast differentiation.


regulation of base-excision repair

description: Any process that modulates the frequency, rate or extent of base-excision repair.


ATP generation from poly-ADP-D-ribose

description: The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.


name: negative regulation of ATP biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process.


name: DPOLA_HUMAN DNA polymerase alpha catalytic subunit (sprot)

description: A DNA polymerase alpha catalytic subunit that is encoded in the genome of human.


name: DNA synthesis involved in UV-damage excision repair

description: Any DNA synthesis that is involved in UV-damage excision repair.


DNA synthesis involved in DNA repair

description: Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.


name: DNA strand elongation involved in DNA replication

description: The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication.


leading strand elongation

description: The process in which an existing DNA strand is extended continuously in a 5' to 3' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Leading strand elongation proceeds in the same direction as the replication fork.


lagging strand elongation

description: The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork.


name: regulation of type I interferon production

description: Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


alpha DNA polymerase:primase complex

description: A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a small stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.


name: IFI6_HUMAN Interferon alpha-inducible protein 6 (sprot)

description: An interferon alpha-inducible protein 6 that is encoded in the genome of human.


name: IFIT2_HUMAN Interferon-induced protein with tetratricopeptide repeats 2 (sprot)

description: An interferon-induced protein with tetratricopeptide repeats 2 that is encoded in the genome of human.


name: IFIT1_HUMAN Interferon-induced protein with tetratricopeptide repeats 1 (sprot)

description: An interferon-induced protein with tetratricopeptide repeats 1 that is encoded in the genome of human.


name: intracellular transport of viral protein in host cell

description: The directed movement of a viral protein within the host cell.


cellular response to type I interferon

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


name: LOX5_HUMAN Polyunsaturated fatty acid 5-lipoxygenase (sprot)

description: A polyunsaturated fatty acid 5-lipoxygenase that is encoded in the genome of human.


arachidonate 5-lipoxygenase activity

description: Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate.


name: leukotriene production involved in inflammatory response

description: The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.


dendritic cell migration

description: The movement of a dendritic cell within or between different tissues and organs of the body.


name: regulation of inflammatory response to wounding

description: Any process that modulates the frequency, rate or extent of the inflammatory response to wounding.


leukotriene A4 biosynthetic process

description: The chemical reactions and pathways resulting in the formation of leukotriene A4.


lipoxin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a lipoxin. A lipoxin is a non-classic eicosanoid and signaling molecule that has four conjugated double bonds and is derived from arachidonic acid.


name: CSF3_HUMAN Granulocyte colony-stimulating factor (sprot)

description: A granulocyte colony-stimulating factor that is encoded in the genome of human.


name: PPBI_HUMAN Intestinal-type alkaline phosphatase (sprot)

description: An intestinal alkaline phosphatase that is encoded in the genome of human.


name: UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase isozyme L1 that is encoded in the genome of human.


omega peptidase activity

description: Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes.


male germ cell proliferation

description: The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population.


axon target recognition

description: The process in which an axon recognizes and binds to a set of cells with which it may form stable connections.


FURIN_HUMAN Furin (sprot)

A furin that is encoded in the genome of human.


viral life cycle

description: A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.


viral protein processing

description: Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein.


nerve growth factor production

description: The appearance of nerve growth factor (NGF) due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels.


peptide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide.


dibasic protein processing

description: Any protein processing achieved by the cleavage of a peptide bond after two basic amino acids within a protein.


cytokine precursor processing

description: The cleavage of a peptide bond in a precursor form of a cytokine, resulting in the mature (active) form of the cytokine.


name: LKHA4_HUMAN Leukotriene A-4 hydrolase (sprot)

description: A leukotriene A-4 hydrolase that is encoded in the genome of human.


leukotriene-A4 hydrolase activity

description: Catalysis of the reaction: H2O + leukotriene A(4) = leukotriene B(4).


tripeptide aminopeptidase activity

description: Catalysis of the hydrolysis of a single N-terminal amino acid residue from a tripeptide.


name: ALDOC_HUMAN Fructose-bisphosphate aldolase C (sprot)

description: A fructose-bisphosphate aldolase C that is encoded in the genome of human.


name: NUDT7_HUMAN Peroxisomal coenzyme A diphosphatase NUDT7 (sprot)

description: A peroxisomal coenzyme A diphosphatase NUDT7 that is encoded in the genome of human.


name: nucleoside diphosphate metabolic process

description: The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.


acetyl-CoA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.


propionyl-CoA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of propionyl-CoA.


name: NUD17_HUMAN Nucleoside diphosphate-linked moiety X motif 17 (sprot)

description: A nucleoside diphosphate-linked moiety X motif 17 that is encoded in the genome of human.


name: FREM3_HUMAN FRAS1-related extracellular matrix protein 3 (sprot)

description: A FRAS1-related extracellular matrix protein 3 that is encoded in the genome of human.


name: RB40L_HUMAN Ras-related protein Rab-40A-like (sprot)

description: A Ras-related protein Rab-40A-like that is encoded in the genome of human.


CO4A_HUMAN Complement C4-A (sprot)

A complement C4-A that is encoded in the genome of human.


CO4B_HUMAN Complement C4-B (sprot)

A complement C4-B that is encoded in the genome of human.


name: detection of molecule of bacterial origin

description: The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal.


NPS_HUMAN Neuropeptide S (sprot)

A neuropeptide S that is encoded in the genome of human.


H2AZ_HUMAN Histone H2A.Z (sprot)

A histone H2A.Z that is encoded in the genome of human.


H2A1_HUMAN Histone H2A type 1 (sprot)

A histone H2A type 1-G/I/K/L/M that is encoded in the genome of human.


name: H2BFM_HUMAN Histone H2B type F-M (sprot)

description: A histone H2B type F-M that is encoded in the genome of human.


name: WEE2_HUMAN Wee1-like protein kinase 2 (sprot)

description: A Wee1-like protein kinase 2 that is encoded in the genome of human.


female pronucleus assembly

description: Assembly of the haploid nucleus of the unfertilized egg.


regulation of meiosis I

description: Any process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.


name: negative regulation of oocyte maturation

description: Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.


TFPT_HUMAN TCF3 fusion partner (sprot)

A TCF3 fusion partner that is encoded in the genome of human.


name: SBK2_HUMAN Serine/threonine-protein kinase SBK2 (sprot)

description: A serine/threonine-protein kinase SBK2 that is encoded in the genome of human.


name: SBK3_HUMAN Uncharacterized serine/threonine-protein kinase SBK3 (sprot)

description: An uncharacterized serine/threonine-protein kinase SBK3 that is encoded in the genome of human.


F163B_HUMAN Protein FAM163B (sprot)

A protein FAM163B that is encoded in the genome of human.


CTXN2_HUMAN Cortexin-2 (sprot)

A cortexin-2 that is encoded in the genome of human.


name: FBSP1_HUMAN F-box/SPRY domain-containing protein 1 (sprot)

description: An F-box/SPRY domain-containing protein 1 that is encoded in the genome of human.


name: cerebral cortex radially oriented cell migration

description: The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain.


cerebral cortex tangential migration

description: The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.


corticospinal tract morphogenesis

description: Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract.


name: NBPF7_HUMAN Putative neuroblastoma breakpoint family member 7 (sprot)


name: F86B2_HUMAN Putative protein N-methyltransferase FAM86B2 (sprot)

description: A putative protein N-methyltransferase FAM86B2 that is encoded in the genome of human.


name: KRA14_HUMAN Keratin-associated protein 1-4 (sprot)

description: A keratin-associated protein 1-4 that is encoded in the genome of human.


name: H2AB1_HUMAN Histone H2A-Bbd type 1 (sprot)

description: A histone H2A-Bbd type 1 that is encoded in the genome of human.


name: H2AB2_HUMAN Histone H2A-Bbd type 2/3 (sprot)

description: A histone H2A-Bbd type 2/3 that is encoded in the genome of human.


name: OR4A8_HUMAN Olfactory receptor 4A8 (sprot)

description: A class II olfactory receptor that is a translation product of the OR4A8 gene in human.


name: O5AL1_HUMAN Olfactory receptor 5AL1 (sprot)

description: An olfactory receptor 5AL1 that is encoded in the genome of human.