name: ZN217_HUMAN Zinc finger protein 217 (sprot)

description: A zinc finger protein 217 that is encoded in the genome of human.


name: BCAS1_HUMAN Breast carcinoma-amplified sequence 1 (sprot)

description: A breast carcinoma-amplified sequence 1 that is encoded in the genome of human.


name: PITX3_HUMAN Pituitary homeobox 3 (sprot)

description: A pituitary homeobox 3 that is encoded in the genome of human.


negative regulation of gliogenesis

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia.


response to immobilization stress

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile.


response to cocaine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.


name: response to methamphetamine hydrochloride

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus.


name: positive regulation of cell proliferation in midbrain

description: Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain.


name: cellular response to glial cell derived neurotrophic factor

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus.


name: TP4A3_HUMAN Protein tyrosine phosphatase type IVA 3 (sprot)

description: A protein tyrosine phosphatase type IVA 3 that is encoded in the genome of human.


name: prenylated protein tyrosine phosphatase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate.


name: positive regulation of establishment of protein localization

description: Any process that activates or increases the frequency, rate or extent of establishment of protein localization.


AVIL_HUMAN Advillin (sprot)

An advillin that is encoded in the genome of human.


Arp2/3 complex binding

description: Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5).


name: regulation of diacylglycerol biosynthetic process

description: Any process that modulates the frequency, rate or extent of diacylglycerol biosynthetic process.


name: H2AY_HUMAN Core histone macro-H2A.1 (sprot)

description: A core histone macro-H2A.1 that is encoded in the genome of human.


sex-chromosome dosage compensation

description: Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes.


rDNA binding

description: Binding to a DNA sequence encoding a ribosomal RNA.


double-stranded methylated DNA binding

description: Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.


regulation of oxidative phosphorylation

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.


name: positive regulation of maintenance of mitotic sister chromatid cohesion

description: Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle.


name: establishment of protein localization to chromatin

description: The directed movement of a protein to a part of a chromosome that is organized into chromatin.


name: negative regulation of transcription of nucleolar large rRNA by RNA polymerase I

description: Any process that stops, prevents or reduces the frequency, rate or extent of transcription of nuclear large rRNA transcript mediated by RNA polymerase I.


regulation of NAD metabolic process

description: Any process that modulates the frequency, rate or extent of NAD metabolic process.


name: negative regulation of cell cycle G2/M phase transition

description: Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle.


name: regulation of response to oxidative stress

description: Any process that modulates the frequency, rate or extent of response to oxidative stress.


name: positive regulation of endodermal cell differentiation

description: Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation.


name: negative regulation of protein localization to chromosome, telomeric region

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to chromosome, telomeric region.


site of DNA damage

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.


sex chromatin

description: Chromatin that is part of a sex chromosome.


SH3L1_HUMAN Adapter SH3BGRL (sprot)

An adapter SH3BGRL that is encoded in the genome of human.


protein-RNA adaptor activity

description: The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way.


name: positive regulation of cytoplasmic translational initiation

description: Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation.


FLNB_HUMAN Filamin-B (sprot)

A filamin-B that is encoded in the genome of human.


keratinocyte development

description: The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure.


name: ZN737_HUMAN Zinc finger protein 737 (sprot)

description: A zinc finger protein 737 that is encoded in the genome of human.


name: NCOR1_HUMAN Nuclear receptor corepressor 1 (sprot)

description: A nuclear receptor corepressor 1 that is encoded in the genome of human.


locomotor rhythm

description: The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.


name: negative regulation of fatty acid metabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.


name: VAMP4_HUMAN Vesicle-associated membrane protein 4 (sprot)

description: A vesicle-associated membrane protein 4 that is encoded in the genome of human.


SNARE complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


name: NDUS6_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (sprot)

description: An NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial that is encoded in the genome of human.


name: PEX14_HUMAN Peroxisomal membrane protein PEX14 (sprot)

description: A peroxisomal membrane protein PEX14 that is encoded in the genome of human.


name: protein import into peroxisome matrix, docking

description: The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane.


name: protein import into peroxisome matrix, translocation

description: The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation.


peroxisome transport along microtubule

description: The directed movement of a peroxisome along a microtubule, mediated by motor proteins.


name: TRIM3_HUMAN Tripartite motif-containing protein 3 (sprot)

description: A tripartite motif-containing protein 3 that is encoded in the genome of human.


name: positive regulation of toll-like receptor 3 signaling pathway

description: Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway.


name: ULK1_HUMAN Serine/threonine-protein kinase ULK1 (sprot)

description: A serine/threonine-protein kinase ULK1 that is encoded in the genome of human.


neuron projection regeneration

description: The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage.


name: positive regulation of autophagosome assembly

description: Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly.


omegasome membrane

description: Any membrane that is part of an omegasome.


name: TULP3_HUMAN Tubby-related protein 3 (sprot)

description: A tubby-related protein 3 that is encoded in the genome of human.


name: intraciliary transport particle A binding

description: Binding to an intraciliary transport particle A (IFT A) complex.


embryonic neurocranium morphogenesis

description: The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain.


bronchus morphogenesis

description: The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs.


name: smoothened signaling pathway involved in dorsal/ventral neural tube patterning

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the dorsal/ventral pattern of the neural tube.


ganglion development

description: The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure.


name: LAT3_HUMAN Large neutral amino acids transporter small subunit 3 (sprot)

description: A large neutral amino acids transporter small subunit 3 that is encoded in the genome of human.


name: negative regulation of amino acid transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: negative regulation of L-leucine import across plasma membrane

description: Any process that stops, prevents or reduces the frequency, rate or extent of L-leucine import across plasma membrane.


name: L-valine transmembrane transporter activity

description: Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid.


name: amino acid transmembrane transporter activity

description: Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.


name: neutral L-amino acid transmembrane transporter activity

description: Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3.


name: L-isoleucine transmembrane transporter activity

description: Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid.


name: L-leucine transmembrane transporter activity

description: Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid.


isoleucine transport

description: The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


L-leucine transport

description: The directed movement of L-leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


L-valine transmembrane transport

description: The directed movement of L-valine across a membrane.


podocyte foot

description: A cell projection of a podocyte (glomerular visceral epithelial cell) forming a foot-like structure projecting from a podocyte primary projection, that wraps around capillaries of a renal glomerulus. Adjacent feet (pedicels) interdigitate, leaving thin filtration slits between them, which are covered by slit diaphragms.


name: GPR32_HUMAN Probable G-protein coupled receptor 32 (sprot)

description: A probable G-protein coupled receptor 32 that is encoded in the genome of human.


name: CISY_HUMAN Citrate synthase, mitochondrial (sprot)

description: A citrate synthase, mitochondrial that is encoded in the genome of human.


citrate (Si)-synthase activity

description: Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.


citrate metabolic process

description: The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle.


name: SPAG7_HUMAN Sperm-associated antigen 7 (sprot)

description: A sperm-associated antigen 7 that is encoded in the genome of human.


name: RM33_HUMAN Large ribosomal subunit protein bL33m (sprot)

description: A large ribosomal subunit protein bL33m that is encoded in the genome of human.


mitochondrial large ribosomal subunit

description: The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).


name: SC22B_HUMAN Vesicle-trafficking protein SEC22b (sprot)

description: A vesicle-trafficking protein SEC22b that is encoded in the genome of human.


name: DEAF1_HUMAN Deformed epidermal autoregulatory factor 1 homolog (sprot)

description: A deformed epidermal autoregulatory factor 1 that is encoded in the genome of human.


name: regulation of mammary gland epithelial cell proliferation

description: Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation.


embryonic skeletal system development

description: The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.


name: PR40A_HUMAN Pre-mRNA-processing factor 40 homolog A (sprot)

description: A pre-mRNA-processing factor 40 homolog A that is encoded in the genome of human.


name: HYPM_HUMAN Huntingtin-interacting protein M (sprot)

description: A huntingtin-interacting protein M that is encoded in the genome of human.


name: TACC1_HUMAN Transforming acidic coiled-coil-containing protein 1 (sprot)

description: A transforming acidic coiled-coil-containing protein 1 that is encoded in the genome of human.


nuclear glucocorticoid receptor binding

description: Binding to a nuclear glucocorticoid receptor.


name: peroxisome proliferator activated receptor binding

description: Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma.


nuclear retinoid X receptor binding

description: Binding to a nuclear retinoid X receptor.


name: nuclear thyroid hormone receptor binding

description: Binding to a nuclear thyroid hormone receptor.


name: NDK6_HUMAN Nucleoside diphosphate kinase 6 (sprot)

description: A nucleoside diphosphate kinase 6 that is encoded in the genome of human.


nucleoside diphosphate kinase activity

description: Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.


name: DPOLQ_HUMAN DNA polymerase theta (sprot)

description: A DNA polymerase theta that is encoded in the genome of human.


name: single-stranded DNA endodeoxyribonuclease activity

description: Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks.


DNA-directed DNA polymerase activity

description: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.


single-stranded DNA helicase activity

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix.


description: Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site.


name: CDC45_HUMAN Cell division control protein 45 homolog (sprot)

description: A CDC45-related protein that is encoded in the genome of human.


DNA replication checkpoint signaling

description: A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.


name: DNA unwinding involved in DNA replication

description: The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.


CMG complex

description: A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication.


name: GGYF1_HUMAN GRB10-interacting GYF protein 1 (sprot)

description: A GRB10-interacting GYF protein 1 that is encoded in the genome of human.


name: MSPD3_HUMAN Motile sperm domain-containing protein 3 (sprot)

description: A motile sperm domain-containing protein 3 that is encoded in the genome of human.


name: FBX24_HUMAN F-box only protein 24 (sprot)

description: An F-box only protein 24 that is encoded in the genome of human.


name: LRCH4_HUMAN Leucine-rich repeat and calponin homology domain-containing protein 4 (sprot)

description: A leucine-rich repeat and calponin homology domain-containing protein 4 that is encoded in the genome of human.


membrane raft assembly

description: The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.


name: positive regulation of toll-like receptor signaling pathway

description: Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway.


MTX2_HUMAN Metaxin-2 (sprot)

A metaxin-2 that is encoded in the genome of human.


mitochondrial transport

description: Transport of substances into, out of or within a mitochondrion.


name: protein insertion into mitochondrial outer membrane

description: The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes.


SAM complex

description: A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex.


MIB complex

description: A mitochondrial intermembrane space bridging complex consisting of components of the MICOS complex in the inner mitochondrial membrane, the SAM complex in the outer membrane, a conserved DNAJ protein (human DNAJC11) and Metaxin 1.


name: VP26A_HUMAN Vacuolar protein sorting-associated protein 26A (sprot)

description: A vacuolar protein sorting-associated protein 26A that is encoded in the genome of human.


tubular endosome

description: A network of fine tubules in the vicinity of the Golgi complex and around the centriole.


retromer, cargo-selective complex

description: The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals.


name: ZN254_HUMAN Zinc finger protein 254 (sprot)

description: A zinc finger protein 254 that is encoded in the genome of human.


name: NDUB1_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 that is encoded in the genome of human.


name: MPPB_HUMAN Mitochondrial-processing peptidase subunit beta (sprot)

description: A mitochondrial-processing peptidase subunit beta that is encoded in the genome of human.


name: protein processing involved in protein targeting to mitochondrion

description: The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments.


name: mitochondrial calcium ion transmembrane transport

description: The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial processing peptidase complex

description: A protein complex consisting of a regulatory subunit (alpha-MPP) and a catalytic subunit (beta-MPP) that catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion.


TECTA_HUMAN Alpha-tectorin (sprot)

An alpha-tectorin that is encoded in the genome of human.


name: MAF_HUMAN Transcription factor Maf (sprot)

description: A transcription factor Maf that is encoded in the genome of human.


megakaryocyte differentiation

description: The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.


USH2A_HUMAN Usherin (sprot)

An usherin that is encoded in the genome of human.


maintenance of animal organ identity

description: The process in which the identity of an animal organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


sensory perception of light stimulus

description: The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


inner ear receptor cell differentiation

description: The process in which relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound.


stereocilia ankle link

description: A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia.


USH2 complex

description: A protein complex composed of four proteins, loss of which results in Usher Syndrome type 2 (USH2 syndrome), a leading genetic cause of combined hearing and vision loss. This complex is conserved in many species; in mice, it is composed of USH2A, GPR98 (aka ADGRV1), WHRN, and PDZD7.


stereocilia ankle link complex

description: A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin.


periciliary membrane compartment

description: A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis.


name: SAP30_HUMAN Histone deacetylase complex subunit SAP30 (sprot)

description: A histone deacetylase complex subunit SAP30 that is encoded in the genome of human.


name: modulation by host of symbiont transcription

description: Any process in which an organism modulates the frequency, rate or extent of its symbiont's transcription.


name: MED24_HUMAN Mediator of RNA polymerase II transcription subunit 24 (sprot)

description: A mediator of RNA polymerase II transcription subunit 24 that is encoded in the genome of human.


name: KTNA1_HUMAN Katanin p60 ATPase-containing subunit A1 (sprot)

description: A katanin p60 ATPase-containing subunit A1 that is encoded in the genome of human.


microtubule severing ATPase activity

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP.


katanin complex

description: A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa).


name: RDH16_HUMAN Retinol dehydrogenase 16 (sprot)

description: A retinol dehydrogenase 16 that is encoded in the genome of human.


11-cis-retinol dehydrogenase

description: Catalysis of the reaction:11-cis-retinol-[retinal-binding-protein] + NAD+ = 11-cis-retinal-[retinol-binding-protein] + NADH.


name: PAGE1_HUMAN P antigen family member 1 (sprot)

description: A P antigen family member 1 that is encoded in the genome of human.


name: ERN1_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE1 (sprot)

description: A serine/threonine-protein kinase/endoribonuclease IRE1 that is encoded in the genome of human.


mRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.


peptidyl-serine autophosphorylation

description: The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein.


IRE1-mediated unfolded protein response

description: The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.


name: mRNA splicing, via endonucleolytic cleavage and ligation

description: Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.


name: positive regulation of endoplasmic reticulum unfolded protein response

description: Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response.


insulin metabolic process

description: The chemical reactions and pathways involving insulin.


description: The phosphorylation of a peptidyl-serine to form peptidyl-O-phospho-L-serine on an identical protein. For example, phosphorylation by the other kinase within a homodimer.


Ire1 complex

description: A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript.


AIP1-IRE1 complex

description: A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein).


IRE1-TRAF2-ASK1 complex

description: A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K).


IRE1-RACK1-PP2A complex

description: A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A.


name: E2F6_HUMAN Transcription factor E2F6 (sprot)

description: A transcription factor E2F6 that is encoded in the genome of human.


name: CRLF1_HUMAN Cytokine receptor-like factor 1 (sprot)

description: A cytokine receptor-like factor 1 that is encoded in the genome of human.


name: ciliary neurotrophic factor receptor binding

description: Binding to a ciliary neurotrophic factor receptor.


CRLF-CLCF1 complex

description: A heterodimeric protein complex that is composed of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene) and cytokine receptor-like factor 1 (product of the CRLF gene) and is secreted into the extracellular space. The CRLF-CLCF1 complex is a ligand for the ciliary neurotrophic factor (CNTF) receptor complex.


name: Z324A_HUMAN Zinc finger protein 324A (sprot)

description: A zinc finger protein 324A that is encoded in the genome of human.


name: NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (sprot)

description: A nuclear receptor subfamily 1 group I member 2 that is encoded in the genome of human.


name: LGR5_HUMAN Leucine-rich repeat-containing G-protein coupled receptor 5 (sprot)

description: A leucine-rich repeat-containing G-protein coupled receptor 5 that is encoded in the genome of human.


oocyte differentiation

description: The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.


name: FRAT2_HUMAN GSK-3-binding protein FRAT2 (sprot)

description: A GSK-3-binding protein FRAT2 that is encoded in the genome of human.


name: PSIP1_HUMAN PC4 and SFRS1-interacting protein (sprot)

description: A PC4 and SFRS1-interacting protein that is encoded in the genome of human.


supercoiled DNA binding

description: Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA.


mRNA 5'-splice site recognition

description: Recognition of the intron 5'-splice site by components of the assembling spliceosome.


ERLN1_HUMAN Erlin-1 (sprot)

An erlin-1 that is encoded in the genome of human.


name: negative regulation of cholesterol biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.


name: TAD2A_HUMAN Transcriptional adapter 2-alpha (sprot)

description: A transcriptional adapter 2-alpha that is encoded in the genome of human.


regulation of tubulin deacetylation

description: Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.


name: SUPT3_HUMAN Transcription initiation protein SPT3 homolog (sprot)

description: A transcription initiation protein SPT3 that is encoded in the genome of human.


GPC4_HUMAN Glypican-4 (sprot)

A glypican-4 that is encoded in the genome of human.


name: NDUS3_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (sprot)

description: An NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial that is encoded in the genome of human.


name: CAH11_HUMAN Carbonic anhydrase-related protein 11 (sprot)

description: A carbonic anhydrase-related protein 11 that is encoded in the genome of human.


carbonate dehydratase activity

description: Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O.


name: SRS10_HUMAN Serine/arginine-rich splicing factor 10 (sprot)

description: A serine/arginine-rich splicing factor 10 that is encoded in the genome of human.


RS domain binding

description: Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing.


cytosolic transport

description: The directed movement of substances or organelles within the cytosol.


name: regulation of mRNA splicing, via spliceosome

description: Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism.


GEMI_HUMAN Geminin (sprot)

A geminin that is encoded in the genome of human.


name: positive regulation of chromatin binding

description: Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.


name: DNA replication preinitiation complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins as part of initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity.


name: negative regulation of DNA-templated DNA replication

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication.


name: CLN5_HUMAN Bis(monoacylglycero)phosphate synthase CLN5 (sprot)

description: A ceroid-lipofuscinosis neuronal protein 5 that is encoded in the genome of human.


description: Catalysis of the reaction: 2 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol).


signal peptide processing

description: The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell.


lysosomal lumen acidification

description: Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.


glycosylation

description: The covalent attachment and further modification of carbohydrate residues to a substrate molecule.


positive regulation of GTP binding

description: Any process that activates or increases the frequency, rate or extent of GTP binding.


vacuolar lumen

description: The volume enclosed within the vacuolar membrane.


name: HSBP1_HUMAN Heat shock factor-binding protein 1 (sprot)

description: A heat shock factor-binding protein 1 that is encoded in the genome of human.


endodermal cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.


CLD11_HUMAN Claudin-11 (sprot)

A claudin-11 that is encoded in the genome of human.


axon ensheathment

description: Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal.


basal part of cell

description: The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.


name: TNR21_HUMAN Tumor necrosis factor receptor superfamily member 21 (sprot)

description: A tumor necrosis factor receptor superfamily member 21 that is encoded in the genome of human.


negative regulation of myelination

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons.


name: negative regulation of interleukin-5 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production.


name: negative regulation of T cell proliferation

description: Any process that stops, prevents or reduces the rate or extent of T cell proliferation.


oligodendrocyte apoptotic process

description: Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons.


name: ECI2_HUMAN Enoyl-CoA delta isomerase 2 (sprot)

description: An enoyl-CoA Delta isomerase 2 that is encoded in the genome of human.


name: KHDR3_HUMAN KH domain-containing, RNA-binding, signal transduction-associated protein 3 (sprot)

description: A KH domain-containing, RNA-binding, signal transduction-associated protein 3 that is encoded in the genome of human.


name: TADA3_HUMAN Transcriptional adapter 3 (sprot)

description: A transcriptional adapter 3 that is encoded in the genome of human.


name: TAF5L_HUMAN TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (sprot)

description: A TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L that is encoded in the genome of human.


name: regulation of somatic stem cell population maintenance

description: Any process that modulates the frequency, rate or extent of somatic stem cell population maintenance.


EED_HUMAN Polycomb protein EED (sprot)

A polycomb protein EED that is encoded in the genome of human.


name: BAF_HUMAN Barrier-to-autointegration factor (sprot)

description: A barrier-to-autointegration factor that is encoded in the genome of human.


mitotic nuclear membrane reassembly

description: The mitotic cell cycle process involving ESCRTIII that results in reformation of the nuclear envelope after mitotic nuclear division. In organisms undergoing closed mitosis this involves resealing or 'repair' of the nuclear envelope in the nuclear bridge.


name: negative regulation of protein ADP-ribosylation

description: Any process that decreases the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.


DNA integration

description: The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.


name: SF3B1_HUMAN Splicing factor 3B subunit 1 (sprot)

description: A splicing factor 3B subunit 1 that is encoded in the genome of human.


splicing factor binding

description: Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA.


U11/U12 snRNP

description: A ribonucleoprotein complex that is formed by the association of the U11 and U12 small nuclear ribonucleoproteins.


name: CSDE1_HUMAN Cold shock domain-containing protein E1 (sprot)

description: A cold shock domain-containing protein E1 that is encoded in the genome of human.


RISC complex binding

description: Binding to a RISC complex.


name: nuclear-transcribed mRNA catabolic process, no-go decay

description: The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation.


name: ZN821_HUMAN Zinc finger protein 821 (sprot)

description: A zinc finger protein 821 that is encoded in the genome of human.


DAB1_HUMAN Disabled homolog 1 (sprot)

A disabled homolog 1 that is encoded in the genome of human.


cerebellum structural organization

description: The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.


name: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration

description: The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex.


name: radial glia guided migration of Purkinje cell

description: The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer.


astrocyte differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.


lateral motor column neuron migration

description: The orderly movement of a lateral motor column neuron from one site to another. A lateral motor column neuron is a motor neuron that is generated only on limb levels and send axons into the limb mesenchyme.


name: radial glia-guided pyramidal neuron migration

description: The radial migration of a pyramidal neuron along radial glial cells.


name: WBP4_HUMAN WW domain-binding protein 4 (sprot)

description: A WW domain-binding protein 4 that is encoded in the genome of human.


SG2A1_HUMAN Mammaglobin-B (sprot)

A mammaglobin-B that is encoded in the genome of human.


STX11_HUMAN Syntaxin-11 (sprot)

A syntaxin-11 that is encoded in the genome of human.


name: SKAP2_HUMAN Src kinase-associated phosphoprotein 2 (sprot)

description: A Src kinase-associated phosphoprotein 2 that is encoded in the genome of human.


name: JERKY_HUMAN Jerky protein homolog (sprot)

description: A jerky protein that is encoded in the genome of human.


name: PRKRA_HUMAN Interferon-inducible double-stranded RNA-dependent protein kinase activator A (sprot)

description: An interferon-inducible double-stranded RNA-dependent protein kinase activator A that is encoded in the genome of human.


pre-miRNA binding

description: Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA.


pre-miRNA processing

description: A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule.


miRNA processing

description: A process leading to the generation of a functional miRNA. Includes the cleavage of stem-loop RNA precursors into microRNAs (miRNAs). miRNAs are a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts.


RISC complex assembly

description: The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing complement complex that mediates gene silencing by small RNA.


RISC-loading complex

description: A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.


name: RF1M_HUMAN Peptide chain release factor 1, mitochondrial (sprot)

description: A peptide chain release factor 1, mitochondrial that is encoded in the genome of human.


translation release factor activity

description: Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.


name: translation release factor activity, codon specific

description: A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site.


mitochondrial translational termination

description: The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa).


name: RPC9_HUMAN DNA-directed RNA polymerase III subunit RPC9 (sprot)

description: A DNA-directed RNA polymerase III subunit RPC9 that is encoded in the genome of human.


DNA polymerase III complex

description: The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork.


ITA10_HUMAN Integrin alpha-10 (sprot)

An integrin alpha-10 that is encoded in the genome of human.


name: collagen binding involved in cell-matrix adhesion

description: Any collagen binding that occurs as part of cell-matrix adhesion.


integrin alpha10-beta1 complex

description: An integrin complex that comprises one alpha10 subunit and one beta1 subunit.


name: LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (sprot)

description: A low-density lipoprotein receptor-related protein 6 that is encoded in the genome of human.


name: low-density lipoprotein particle receptor activity

description: Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis.


neural crest cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.


name: negative regulation of smooth muscle cell apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process.


cellular response to cholesterol

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.


name: KS6A5_HUMAN Ribosomal protein S6 kinase alpha-5 (sprot)

description: A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of human.


histone H3S28 kinase activity

description: Catalysis of the reaction: histone H3-serine (position 28) + ATP = histone H3-phosphoserine (position 28) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 28 of histone H3.


histone H2AS1 kinase activity

description: Catalysis of the reaction: histone H2A-serine (position 1) + ATP = histone H2A-phosphoserine (position 1) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 1 of histone H2A.


name: positive regulation of CREB transcription factor activity

description: Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.


name: MED6_HUMAN Mediator of RNA polymerase II transcription subunit 6 (sprot)

description: A mediator of RNA polymerase II transcription subunit 6 that is encoded in the genome of human.


name: MYCB2_HUMAN E3 ubiquitin-protein ligase MYCBP2 (sprot)

description: An E3 ubiquitin-protein ligase MYCBP2 that is encoded in the genome of human.


neuromuscular process

description: Any process pertaining to the functions of the nervous and muscular systems of an organism.


regulation of axon guidance

description: Any process that modulates the frequency, rate or extent of axon guidance.


name: FOXH1_HUMAN Forkhead box protein H1 (sprot)

description: A forkhead box protein H1 that is encoded in the genome of human.


secondary heart field specification

description: The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).


name: determination of left/right asymmetry in lateral mesoderm

description: The establishment of the lateral mesoderm with respect to the left and right halves.


cardiac right ventricle morphogenesis

description: The process in which the right cardiac ventricle is generated and organized.


name: ventricular trabecula myocardium morphogenesis

description: The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized.


name: embryonic heart tube anterior/posterior pattern specification

description: The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta.


nodal signaling pathway

description: The series of molecular signals initiated by nodal protein binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


activin responsive factor complex

description: A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor.


name: PGRP1_HUMAN Peptidoglycan recognition protein 1 (sprot)

description: A peptidoglycan recognition protein 1 that is encoded in the genome of human.


description: Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides.


peptidoglycan immune receptor activity

description: Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response.


peptidoglycan catabolic process

description: The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.


detection of bacterium

description: The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.


name: negative regulation of natural killer cell differentiation involved in immune response

description: Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response.


name: biological process involved in interaction with host

description: An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.


name: CLC3A_HUMAN C-type lectin domain family 3 member A (sprot)

description: A C-type lectin domain family 3 member A that is encoded in the genome of human.


name: KBL_HUMAN 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (sprot)

description: A 2-amino-3-ketobutyrate coenzyme A ligase that is encoded in the genome of human.


glycine C-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA.


threonine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.


biosynthetic process

description: The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.


name: SPAG6_HUMAN Sperm-associated antigen 6 (sprot)

description: A sperm-associated antigen 6 that is encoded in the genome of human.


name: GCM2_HUMAN Chorion-specific transcription factor GCMb (sprot)

description: A chorion-specific transcription factor GCMb that is encoded in the genome of human.


name: UBP2_HUMAN Ubiquitin carboxyl-terminal hydrolase 2 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 2 that is encoded in the genome of human.


NPM3_HUMAN Nucleoplasmin-3 (sprot)

A nucleoplasmin-3 that is encoded in the genome of human.


name: LYPA1_HUMAN Acyl-protein thioesterase 1 (sprot)

description: An acyl-protein thioesterase 1 that is encoded in the genome of human.


palmitoyl-(protein) hydrolase activity

description: Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.


lipase activity

description: Catalysis of the hydrolysis of a lipid or phospholipid.


protein depalmitoylation

description: The removal of palymitoyl groups from a lipoprotein.


name: negative regulation of Golgi to plasma membrane protein transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.


negative regulation of aggrephagy

description: Any process that stops, prevents or reduces the frequency, rate or extent of aggrephagy.


name: LFTY1_HUMAN Left-right determination factor 1 (sprot)

description: A lefty 1 that is encoded in the genome of human.


name: ERAL1_HUMAN GTPase Era, mitochondrial (sprot)

description: A GTP-binding protein era that is encoded in the genome of human.


rRNA binding

description: Binding to a ribosomal RNA.


name: DEDD_HUMAN Death effector domain-containing protein (sprot)

description: A death effector domain-containing protein that is encoded in the genome of human.


name: PRDM1_HUMAN PR domain zinc finger protein 1 (sprot)

description: A PR domain zinc finger protein 1 that is encoded in the genome of human.


maternal placenta development

description: Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.


name: regulation of natural killer cell differentiation

description: Any process that modulates the frequency, rate or extent of natural killer cell differentiation.


name: regulation of extrathymic T cell differentiation

description: Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation.


regulation of NK T cell differentiation

description: Any process that modulates the frequency, rate or extent of natural killer T cell differentiation.


retinal bipolar neuron differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a bipolar cell, the last neuron to be generated in the retina.


intestinal epithelial cell development

description: The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure.


sebum secreting cell proliferation

description: The multiplication or reproduction of sebocytes by cell division, resulting in the expansion of their population. A sebocyte is an epithelial cell that makes up the sebaceous glands, and secrete sebum.


name: REM1_HUMAN GTP-binding protein REM 1 (sprot)

description: A GTP-binding protein REM 1 that is encoded in the genome of human.


name: regulation of skeletal muscle contraction by calcium ion signaling

description: Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction.


CREG1_HUMAN Protein CREG1 (sprot)

A protein CREG1 that is encoded in the genome of human.


UPK3A_HUMAN Uroplakin-3a (sprot)

A uroplakin-3a that is encoded in the genome of human.


potassium ion homeostasis

description: Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell.


sodium ion homeostasis

description: Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell.


urinary bladder development

description: The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion.


SPB7_HUMAN Serpin B7 (sprot)

A serpin B7 that is encoded in the genome of human.


name: positive regulation of transforming growth factor beta1 production

description: Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1.


name: positive regulation of collagen biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.


name: positive regulation of platelet-derived growth factor production

description: Any process that increases the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


FCN3_HUMAN Ficolin-3 (sprot)

A ficolin-3 that is encoded in the genome of human.


complement activation

description: Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.


name: negative regulation of RNA biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process.


name: CTAG2_HUMAN Cancer/testis antigen 2 (sprot)

description: A cancer/testis antigen 2 that is encoded in the genome of human.


name: U520_HUMAN U5 small nuclear ribonucleoprotein 200 kDa helicase (sprot)

description: A U5 small nuclear ribonucleoprotein 200 kDa helicase that is encoded in the genome of human.


name: cis assembly of pre-catalytic spliceosome

description: Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner.


name: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)

description: Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11).


U5 snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes.


name: MTU1_HUMAN Mitochondrial tRNA-specific 2-thiouridylase 1 (sprot)

description: A mitochondrial tRNA-specific 2-thiouridylase 1 that is encoded in the genome of human.


description: Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+.


TIPRL_HUMAN TIP41-like protein (sprot)

A TIP41-like protein that is encoded in the genome of human.


name: negative regulation of phosphoprotein phosphatase activity

description: Any process that stops or reduces the activity of a phosphoprotein phosphatase.


name: OFD1_HUMAN Centriole and centriolar satellite protein OFD1 (sprot)

description: A centriole and centriolar satellite protein OFD1 that is encoded in the genome of human.


embryonic body morphogenesis

description: The process in which the anatomical structures of the embryonic soma are generated and organized.


name: negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

description: Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation.


TM1L1_HUMAN TOM1-like protein 1 (sprot)

A TOM1-like protein 1 that is encoded in the genome of human.


regulation of DNA biosynthetic process

description: Any process that modulates the frequency, rate or extent of DNA biosynthetic process.


name: KS6A4_HUMAN Ribosomal protein S6 kinase alpha-4 (sprot)

description: A ribosomal protein S6 kinase alpha-4 that is encoded in the genome of human.


ribosomal protein S6 kinase activity

description: Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.


name: RFPL1_HUMAN Ret finger protein-like 1 (sprot)

description: A ret finger protein-like 1 that is encoded in the genome of human.


negative regulation of cell division

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.


name: positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

description: Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis.


name: RFPL2_HUMAN Ret finger protein-like 2 (sprot)

description: A ret finger protein-like 2 that is encoded in the genome of human.


name: RFPL3_HUMAN Ret finger protein-like 3 (sprot)

description: A ret finger protein-like 3 that is encoded in the genome of human.


name: SURF6_HUMAN Surfeit locus protein 6 (sprot)

description: A surfeit locus protein 6 that is encoded in the genome of human.


granular component

description: A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm.


name: PPM1B_HUMAN Protein phosphatase 1B (sprot)

description: A protein phosphatase 1B that is encoded in the genome of human.


N-terminal protein myristoylation

description: The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein.


name: negative regulation of interferon-beta production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production.


name: ADAP1_HUMAN Arf-GAP with dual PH domain-containing protein 1 (sprot)

description: An Arf-GAP with dual PH domain-containing protein 1 that is encoded in the genome of human.


description: Binding to phosphatidylinositol bisphosphate.


name: KRA58_HUMAN Keratin-associated protein 5-8 (sprot)

description: A keratin-associated protein 5-8 that is encoded in the genome of human.


name: structural constituent of skin epidermis

description: The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure.


name: UTP20_HUMAN Small subunit processome component 20 homolog (sprot)

description: A small subunit processome component 20 that is encoded in the genome of human.


name: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.


name: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.


name: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable.


90S preribosome

description: A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.


name: NU155_HUMAN Nuclear pore complex protein Nup155 (sprot)

description: A nuclear pore complex protein Nup155 that is encoded in the genome of human.


name: atrial cardiac muscle cell action potential

description: An action potential that occurs in an atrial cardiac muscle cell.


XRP2_HUMAN Protein XRP2 (sprot)

A protein XRP2 that is encoded in the genome of human.


name: SCRG1_HUMAN Scrapie-responsive protein 1 (sprot)

description: A scrapie-responsive protein 1 that is encoded in the genome of human.


name: CXB3_HUMAN Gap junction beta-3 protein (sprot)

description: A gap junction beta-3 protein that is encoded in the genome of human.


gap junction channel activity

description: A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.


gap junction

description: A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins.


name: GPX5_HUMAN Epididymal secretory glutathione peroxidase (sprot)

description: An epididymal secretory glutathione peroxidase that is encoded in the genome of human.


name: STK16_HUMAN Serine/threonine-protein kinase 16 (sprot)

description: A serine/threonine-protein kinase 16 that is encoded in the genome of human.


name: WDHD1_HUMAN WD repeat and HMG-box DNA-binding protein 1 (sprot)

description: A WD repeat and HMG-box DNA-binding protein 1 that is encoded in the genome of human.


name: CRTAP_HUMAN Cartilage-associated protein (sprot)

description: A cartilage-associated protein that is encoded in the genome of human.


name: negative regulation of post-translational protein modification

description: Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification.


name: S2512_HUMAN Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (sprot)

description: An electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial that is encoded in the genome of human.


name: 3-sulfino-L-alanine: proton, glutamate antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-sulfino-L-alanine (cysteinesulfinate) (out) + H+(in) + L-glutamate(in) = 3-sulfino-L-alanine(in) + H+(out) + L-glutamate(out).


name: aspartate:glutamate, proton antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-aspartate(in) + L-glutamate(out) = H+(in) + L-aspartate(out) + L-glutamate(in).


name: acidic amino acid transmembrane transporter activity

description: Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3.


name: aspartate family amino acid metabolic process

description: The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.


aspartate transmembrane transport

description: The process in which aspartate is transported across a lipid bilayer, from one side of a membrane to the other.


malate-aspartate shuttle

description: The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.


L-aspartate transmembrane transport

description: The directed movement of L-aspartate across a membrane by means of some agent such as a transporter or a pore.


name: P3C2G_HUMAN Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma (sprot)

description: A phosphatidylinositol 3-kinase C2 domain-containing subunit gamma that is encoded in the genome of human.


name: S22A3_HUMAN Solute carrier family 22 member 3 (sprot)

description: A solute carrier family 22 member 3 that is encoded in the genome of human.


histamine metabolic process

description: The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.


monocarboxylic acid transport

description: The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


regulation of appetite

description: Any process which modulates appetite, the desire or physical craving for food.


epinephrine uptake

description: The directed movement of epinephrine into a cell, typically presynaptic neurons or glial cells. Epinephrine is a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.


nuclear outer membrane

description: The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.


name: B3GL1_HUMAN UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (sprot)

description: A UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide.


name: TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 (sprot)

description: A transient receptor potential cation channel TRPA1 that is encoded in the genome of human.


name: intracellularly gated calcium channel activity

description: Enables the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.


name: temperature-gated cation channel activity

description: Enables the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism).


thermoception

description: The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature).


name: detection of mechanical stimulus involved in sensory perception of pain

description: The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal.


name: detection of chemical stimulus involved in sensory perception of pain

description: The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal.


name: TCEA3_HUMAN Transcription elongation factor A protein 3 (sprot)

description: A transcription elongation factor A protein 3 that is encoded in the genome of human.


name: RA51D_HUMAN DNA repair protein RAD51 homolog 4 (sprot)

description: A DNA repair protein RAD51 homolog 4 that is encoded in the genome of human.


PALM_HUMAN Paralemmin-1 (sprot)

A paralemmin that is encoded in the genome of human.


D3 dopamine receptor binding

description: Binding to a D3 dopamine receptor.


synapse maturation

description: The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.


name: negative regulation of dopamine receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of dopamine receptor protein signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.


name: cellular response to electrical stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.


name: RHBL1_HUMAN Rhomboid-related protein 1 (sprot)

description: A rhomboid-related protein 1 that is encoded in the genome of human.


RENR_HUMAN Renin receptor (sprot)

A renin receptor that is encoded in the genome of human.


angiotensin maturation

description: The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood.


central nervous system maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.


rostrocaudal neural tube patterning

description: The process in which the neural tube is divided into specific regions along the rostrocaudal axis.


eye pigmentation

description: Establishment of a pattern of pigment in the eye of an organism.


endosomal lumen acidification

description: Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion.


head morphogenesis

description: The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body.


Golgi lumen acidification

description: Any process that reduces the pH of the Golgi lumen, measured by the concentration of the hydrogen ion.


synaptic vesicle lumen acidification

description: The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading.


name: proton-transporting V-type ATPase complex

description: A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.


name: vacuolar proton-transporting V-type ATPase, V0 domain

description: The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.


name: vacuolar proton-transporting V-type ATPase complex

description: A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.


name: GRAP2_HUMAN GRB2-related adapter protein 2 (sprot)

description: A GRB2-related adapter protein 2 that is encoded in the genome of human.


name: RNH2A_HUMAN Ribonuclease H2 subunit A (sprot)

description: A ribonuclease H2 subunit A that is encoded in the genome of human.


ribonuclease H2 complex

description: A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p.


name: CD123_HUMAN Translation initiation factor eIF2 assembly protein (sprot)

description: A cell division cycle protein 123 that is encoded in the genome of human.


name: eukaryotic translation initiation factor 2 complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2 complex.


name: UDB17_HUMAN UDP-glucuronosyltransferase 2B17 (sprot)

description: A UDP-glucuronosyltransferase 2B17 that is encoded in the genome of human.


name: ZMY10_HUMAN Zinc finger MYND domain-containing protein 10 (sprot)

description: A zinc finger MYND domain-containing protein 10 that is encoded in the genome of human.


name: positive regulation of motile cilium assembly

description: Any process that activates or increases the frequency, rate or extent of motile cilium assembly.


name: PR15A_HUMAN Protein phosphatase 1 regulatory subunit 15A (sprot)

description: A protein phosphatase 1 regulatory subunit 15A that is encoded in the genome of human.


protein phosphatase activator activity

description: Binds to and increases the activity of a protein phosphatase.


name: positive regulation of translational initiation in response to stress

description: Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress.


name: positive regulation of phosphoprotein phosphatase activity

description: Any process that activates or increases the activity of a phosphoprotein phosphatase.


name: negative regulation of protein dephosphorylation

description: Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein.


name: regulation of translational initiation by eIF2 alpha dephosphorylation

description: Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha.


name: protein localization to endoplasmic reticulum

description: A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum.


name: negative regulation of PERK-mediated unfolded protein response

description: Any process that stops, prevents or reduces the frequency, rate or extent of the PERK-mediated unfolded protein response.


name: positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation

description: Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation.


protein phosphatase type 1 complex

description: A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity.


CAN15_HUMAN Calpain-15 (sprot)

A calpain-15 that is encoded in the genome of human.


name: BCAR3_HUMAN Breast cancer anti-estrogen resistance protein 3 (sprot)

description: A breast cancer anti-estrogen resistance protein 3 that is encoded in the genome of human.


name: POP7_HUMAN Ribonuclease P protein subunit p20 (sprot)

description: A ribonuclease P protein subunit p20 that is encoded in the genome of human.


ribonuclease P RNA binding

description: Binding to RNA subunit of ribonuclease P.


tRNA 5'-leader removal

description: Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.


ribonuclease MRP complex

description: A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.


nucleolar ribonuclease P complex

description: A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.


multimeric ribonuclease P complex

description: A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species.


name: RPP40_HUMAN Ribonuclease P protein subunit p40 (sprot)

description: A ribonuclease P protein subunit p40 that is encoded in the genome of human.


name: ZN189_HUMAN Zinc finger protein 189 (sprot)

description: A zinc finger protein 189 that is encoded in the genome of human.


name: EIF3G_HUMAN Eukaryotic translation initiation factor 3 subunit G (sprot)

description: A eukaryotic translation initiation factor 3 subunit G that is encoded in the genome of human.


name: EIF3J_HUMAN Eukaryotic translation initiation factor 3 subunit J (sprot)

description: A eukaryotic translation initiation factor 3 subunit J that is encoded in the genome of human.


name: CBR3_HUMAN Carbonyl reductase [NADPH] 3 (sprot)

description: A carbonyl reductase [NADPH] 3 that is encoded in the genome of human.


3-keto sterol reductase activity

description: Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+.


carbonyl reductase (NADPH) activity

description: Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.


NADPH dehydrogenase (quinone) activity

description: Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol.


NADPH binding

description: Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.


phylloquinone catabolic process

description: The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants.


name: CNMD_HUMAN Leukocyte cell-derived chemotaxin 1 (sprot)

description: A chondromodulin-1 that is encoded in the genome of human.


proteoglycan metabolic process

description: The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


SPI2_HUMAN Serpin I2 (sprot)

A serpin I2 that is encoded in the genome of human.


name: PSD10_HUMAN 26S proteasome non-ATPase regulatory subunit 10 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 10 that is encoded in the genome of human.


name: positive regulation of cyclin-dependent protein serine/threonine kinase activity

description: Any process that activates or increases the frequency, rate or extent of CDK activity.


name: CIB2_HUMAN Calcium and integrin-binding family member 2 (sprot)

description: A calcium and integrin-binding family member 2 that is encoded in the genome of human.


cellular response to ATP

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.


muscle tendon junction

description: A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons.


cuticular plate

description: A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted.


name: KLF7_HUMAN Krueppel-like factor 7 (sprot)

description: A krueppel-like factor 7 that is encoded in the genome of human.


name: regulation of epidermal cell differentiation

description: Any process that modulates the frequency, rate or extent of epidermal cell differentiation.


name: negative regulation of insulin secretion involved in cellular response to glucose stimulus

description: Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.


name: negative regulation of adipose tissue development

description: Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development.


UPK1B_HUMAN Uroplakin-1b (sprot)

A uroplakin-1b that is encoded in the genome of human.


name: AP1G2_HUMAN AP-1 complex subunit gamma-like 2 (sprot)

description: An AP-1 complex subunit gamma-like 2 that is encoded in the genome of human.


name: FACE1_HUMAN CAAX prenyl protease 1 homolog (sprot)

description: A CAAX prenyl protease 1 that is encoded in the genome of human.


regulation of defense response to virus

description: Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.


metalloexopeptidase activity

description: Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


name: ventricular cardiac muscle tissue development

description: The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.


cardiac ventricle development

description: The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.


growth plate cartilage development

description: The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow.


inflammatory cell apoptotic process

description: Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage.


determination of adult lifespan

description: The pathways that regulate the duration of the adult phase of the life-cycle of an animal.


prenylated protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of prenylated proteins.


regulation of hormone metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone.


maintenance of rDNA

description: Any process involved in sustaining the fidelity and copy number of rDNA repeats.


name: regulation of DNA damage response, signal transduction by p53 class mediator

description: Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.


cellular lipid metabolic process

description: The chemical reactions and pathways involving lipids, as carried out by individual cells.


regulation of fibroblast proliferation

description: Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells.


kidney morphogenesis

description: Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


name: regulation of stress-activated protein kinase signaling cascade

description: Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade.


name: response to DNA damage checkpoint signaling

description: A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling.


name: regulation of mitotic cell cycle DNA replication

description: Any process that modulates the frequency, rate or extent of mitotic cell cycle DNA replication.


negative regulation of miRNA processing

description: Any process that stops, prevents or reduces the frequency, rate or extent of microRNA processing.


name: regulation of termination of RNA polymerase I transcription

description: Any process that modulates the frequency, rate or extent of termination of RNA polymerase I transcription.


SC5D_HUMAN Lathosterol oxidase (sprot)

A lathosterol oxidase that is encoded in the genome of human.


delta7-sterol 5(6)-desaturase activity

description: Catalysis of the reaction: a delta(7)-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ -> a delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O.


name: cholesterol biosynthetic process via desmosterol

description: The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate desmosterol.


name: cholesterol biosynthetic process via lathosterol

description: The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol.


name: PPR37_HUMAN Protein phosphatase 1 regulatory subunit 37 (sprot)

description: A protein phosphatase 1 regulatory subunit 37 that is encoded in the genome of human.


name: TPC6A_HUMAN Trafficking protein particle complex subunit 6A (sprot)

description: A trafficking protein particle complex subunit 6A that is encoded in the genome of human.


name: CEAM4_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 4 (sprot)

description: A carcinoembryonic antigen-related cell adhesion molecule 4 that is encoded in the genome of human.


name: IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (sprot)

description: An isocitrate dehydrogenase [NADP] cytoplasmic that is encoded in the genome of human.


name: isocitrate dehydrogenase (NADP+) activity

description: Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.


glyoxylate cycle

description: A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.


isocitrate metabolic process

description: The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle.


response to steroid hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.


name: regulation of phospholipid catabolic process

description: Any process that modulates the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.


name: regulation of phospholipid biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids.


name: GATB_HUMAN Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (sprot)

description: A glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial that is encoded in the genome of human.


name: SCO1_HUMAN Protein SCO1 homolog, mitochondrial (sprot)

description: A protein SCO1, mitochondrial that is encoded in the genome of human.


CP7B1_HUMAN Cytochrome P450 7B1 (sprot)

A cytochrome P450 7B1 that is encoded in the genome of human.


oxysterol 7-alpha-hydroxylase activity

description: Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O.


description: Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced [NADPH-hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized [NADPH-hemoprotein reductase].


description: Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O.


sterol metabolic process

description: The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


prostate gland epithelium morphogenesis

description: The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.


ATRN_HUMAN Attractin (sprot)

An attractin that is encoded in the genome of human.


cerebellum development

description: The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.


name: RBBP9_HUMAN Serine hydrolase RBBP9 (sprot)

description: A serine hydrolase RBBP9 that is encoded in the genome of human.


response to nematode

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode.


name: STAM2_HUMAN Signal transducing adapter molecule 2 (sprot)

description: A signal transducing adapter molecule 2 that is encoded in the genome of human.


name: TNF13_HUMAN Tumor necrosis factor ligand superfamily member 13 (sprot)

description: A tumor necrosis factor ligand superfamily member 13 (human), isoforms alpha, beta, gamma, 4, and 5.


name: positive regulation of isotype switching to IgA isotypes

description: Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes.


name: AL1L1_HUMAN Cytosolic 10-formyltetrahydrofolate dehydrogenase (sprot)

description: A 10-formyltetrahydrofolate dehydrogenase that is encoded in the genome of human.


description: Catalysis of the reaction: 10-formyltetrahydrofolate + H2O + NADP+ = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H+ + NADPH.


NADPH regeneration

description: A metabolic process that generates a pool of NADPH by the reduction of NADP+.