nucleoplasmic THO complex

description: The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits.


larval serum protein complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins.


cytoplasmic ubiquitin ligase complex

description: A ubiquitin ligase complex found in the cytoplasm.


name: homodimeric polyprenyl diphosphate synthase complex

description: A homodimeric complex that possesses polyprenyl diphosphate synthase activity involved in the synthesis of the isoprenoid chain of ubiquinone whose length varies between organisms.


egasyn-beta-glucuronidase complex

description: A protein complex that contains beta-glucuronidase and the carboxyl esterase egasyn; formation of the complex causes beta-glucuronidase to be retained in the endoplasmic reticulum.


alpha9-beta1 integrin-tenascin complex

description: A protein complex that consists of an alpha9-beta1 integrin complex bound to the extracellular matrix protein tenascin.


SRF-myogenin-E12 complex

description: A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes.


TAM protein secretion complex

description: A heterooligomeric protein complex that spans the bacterial periplasm and enables the secretion of adhesin proteins in Gram-negative bacteria. In Citrobacter rodentium, Salmonella enterica and Escherichia coli, the TAM complex consists of an Omp85-family protein, TamA, in the outer membrane and TamB in the inner membrane.


spitzenkorper

description: Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments.


DnaA-oriC complex

description: A protein-DNA complex containing the initiator protein DnaA bound to high-affinity recognition sites in the unique origin of replication, oriC. DnaA-oriC binding is the first step in assembly of a bacterial pre-replicative complex (pre-RC) and is responsible for the timely initiation of replication once per cell cycle.


maltose transport complex

description: Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK.


interferon regulatory factor complex

description: A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit.


description: A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin.


respiratory chain complex

description: Any protein complex that is part of a respiratory chain.


plastid mRNA editing complex

description: An mRNA editing complex found in a plastid.


TFIIIC-TOP1-SUB1 complex

description: A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III.


SCF-Cdc4 ubiquitin ligase complex

description: An SCF ubiquitin ligase complex in which the F-box protein is Cdc4 in S. cerevisiae.


name: anaerobic ribonucleoside-triphosphate reductase complex

description: An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit.


RAD52-ERCC4-ERCC1 complex

description: A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein.


description: A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2.


nucleolar preribosome

description: Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis.


1,3-beta-D-glucan synthase complex

description: A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain.


protein-DNA ISRE complex

description: A protein-DNA complex formed through interaction of the protein(s) with an interferon-stimulated response element (ISRE) in the DNA.


Scrib-APC complex

description: A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation.


cytochrome o ubiquinol oxidase complex

description: A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups.


pre-replicative complex

description: A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.


radial spoke 3

description: Radial spoke 3 (RS3), when present, is the most distal of each group of radial spokes, whether grouped as triplets or doublets. RS3 has significantly different morphology and protein composition than RS1 and RS2 and also extends at a slant from the microtubule doublet, rather than perpendicularly like RS1 and RS2. In some organisms (e.g. Chlamydomonas and Sarcophaga bullata), RS3 is represented only as a stump attached to the A-microtubule lacking the rest of the stalk structure and entirely lacking the head structure.


G-protein alpha(i)1-synembrin complex

description: A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(i)1 subunit of a heterotrimeric G protein.


NHE3/E3KARP/ACTN4 complex

description: A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments.


methionine-importing complex

description: A protein complex which is capable of methionine-importing activity.


contractile vacuole pore

description: Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium.


Aim21-Tda2 complex

description: A complex that localizes to actin cortical patches at sites of endocytosis and negatively regulates barbed end F-actin assembly, resulting in the generation of free actin pools. The Aim21-Tda2 complex is necessary for efficient endocytosis and balancing the distribution of actin between patches and cables.


DnaB-DnaC-DnaT-PriA-PriC complex

description: A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired.


interleukin-27 complex

description: A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space.


carbon phosphorus lyase complex

description: A protein complex which is capable of carbon phosphorus lyase activity.


RNA decapping complex

description: A protein complex consisting of a Dcp1 regulatory subunit and a Dcp2 catalytic subunit that has mRNA cap binding activity and is involved in decapping of nuclear-transcribed mRNA.


CD20-Lck-Fyn complex

description: A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck and Fyn.


Cbf1-Met4-Met28 complex

description: A heteromeric complex consisting of Cbf1 and basic leucine zipper (bZIP) containing transcriptional activators, Met4 and Met28, that forms over the sequence TCACGTG in the upstream activating sequence (UAS) of genes involved in sulfur amino acid metabolism, resulting in their transcriptional activation.


glutamate dehydrogenase complex

description: A homomeric protein complex that possesses glutamate dehydrogenase activity. This complex is evolutionarily conserved except that the number of homoprotomers per complex varies.


name: chloroplast ribulose bisphosphate carboxylase complex

description: A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana.


alpha3-beta1 integrin-CD151 complex

description: A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD151.


light-harvesting complex

description: A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center.


radial spoke base 3

description: The short portion of the radial spoke 3 (RS3 )that is directly anchored to the A microtubule of an axonemal microtubule doublet.


adenylyltransferase complex

description: A protein complex which is capable of adenylyltransferase activity.


box C/D methylation guide RNP complex

description: A ribonucleoprotein complex containing a box C/D type snoRNA and three (Archaea) or four (Eukaryotes) core proteins that is capable of methylation of target RNAs.


description: A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.


name: meiotic recombination initiation complex

description: A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins.


cargo receptor complex

description: Any protein complex that is part of a membrane and which functions as a cargo receptor.


description: A heterotetrameric protein complex which adenylates two molecules of the sulfur carrier subunit of the molybdopterin cofactor synthase using ATP as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoeB and MoaD; in human the subunits are MOCS3 and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved.


description: A protein complex which is capable of glycerol-3-phosphate-transporting ATPase activity.


lipopolysaccharide transport system

description: A protein-containing complex that functions to transport lipopolysaccharide from its site of synthesis at the cytoplasmic membrane across the periplasm to the outer membrane in an ATP-dependent manner.


name: proton-transporting ATP synthase, central stalk

description: One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis.


alpha6-beta4 integrin-Shc-Grb2 complex

description: A protein complex that consists of an alpha6-beta4 integrin complex bound to the adaptor proteins Shc and Grb2.


name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex

description: A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt3p.


alpha9-beta1 integrin-VEGF-D complex

description: A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D.


description: A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin.


name: PSII associated light-harvesting complex II, core complex

description: The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center.


alphav-beta3 integrin-CD47 complex

description: A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP).


COPII vesicles tethering complex

description: A protein complex that resides in the cis-golgi membrane and plays a role in the tethering of COPII vesicles, through an interaction with vesicle tethering proteins (p115 in H. Sapiens and Uso1 S. cerevisiae), granting the cis-Golgi and endoplasmic reticulum to Golgi vesicle-mediated transport. It is composed by GRASP65 and GM130 protein in H. sapiens and by Bug1 and Grh1 proteins in S. cerevisiae.


MCM core complex

description: A protein complex that contains Mcm4, Mcm6, and Mcm7 proteins, and possesses DNA helicase activity. In the heterohexameric MCM complex, the Mcm4/6/7 proteins form a stable core, and Mcm2, Mcm3, and Mcm5 are more peripherally associated.


curli secretion complex

description: A protein-containing complex that serves as a channel for the secretion of curli. Curli are a fibers that serve as a major component of the extracellular matrix of pellicle biofilms.


name: homotetrameric ADPG pyrophosphorylase complex

description: A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species.


name: interferon regulatory factor 3-interferon regulatory factor 5 complex

description: An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 5.


ARC complex

description: A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA.


SCF-YDR131C ubiquitin ligase complex

description: An SCF ubiquitin ligase complex in which the F-box protein is YDR131C in S. cerevisiae.


name: chloroplast proton-transporting ATP synthase complex, catalytic core CF(1)

description: The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits.


acid phosphatase complex

description: A protein complex which is capable of acid phosphatase activity.


name: phosphatidylinositol phosphate phosphatase complex

description: A protein complex which is capable of phosphatidylinositol phosphate phosphatase activity.


high-affinity iron exporter complex

description: A protein complex which transports ferrous iron (Fe(III) or Fe3+) ions from the vacuole, the main storage component of intracellular free iron, into the cytoplasm in a low iron environment.


SLAC complex

description: A protein complex that regulates Arp2/3 complex-mediated actin nucleation.


endobrevin-SNAP-25-syntaxin-2 complex

description: A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 2 (or orthologs thereof).


alpha-ketoacid dehydrogenase complex

description: A multi-enzyme complex that catalyzes the oxidative decarboxylation of an alpha-ketoacid - pyruvate, a branched-chain alpha-ketoacid or alpha-ketoglutarate (also known as 2-oxoglutarate). The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: a dihydrolipoyl transacylase (E2) forms the core of the complex, with an alpha-ketoacid dehydrogenase (E1) and a dihydrolipoamide dehydrogenase (E3) attached through non-covalent bonds. The E1 and E2 components are specific to different alpha-ketoacid dehydrogenase complexes, whereas the E3 component is the same. Additional proteins may also be present.


Vma12-Vma22 assembly complex

description: A protein complex that is involved in the assembly of the V-ATPase complex. In the budding yeast Saccharomyces cerevisiae, this complex consists of Vma12p and Vma22p.


name: ATPase dependent transmembrane transport complex

description: A transmembrane protein complex that functions in ATPase dependent active transport across a membrane.


laminin-14 complex

description: A laminin complex composed of alpha4, beta2 and gamma3 polypeptide chains.


U4atac/U6atac snRNP

description: A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4atac and U6atac, a heptameric ring of Sm proteins associated with U4atac, the Lsm2-8 heptameric ring complex associated with U6atac, as well as several proteins that are unique to the U4atac snRNP or U6atac snRNPs, some of which remain associated with the U4atac/U6atac snRNA both while the U4atac snRNP is free or assembled into a series of spliceosomal complexes.


endobrevin-SNAP-25-syntaxin-1a complex

description: A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof).


description: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane.


nitrogenase complex

description: An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen.


ferroxidase complex

description: A protein complex which is capable of ferroxidase activity.


respiratory chain complex III

description: A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species.


dimeric ribonuclease P complex

description: A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species.


type III polyketide synthase complex

description: A polyketide synthase complex that consists of two identical ketosynthase polypeptides.


syntaxin-6-syntaxin-16-Vti1a complex

description: A SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof).


TRAIL death-inducing signaling complex

description: A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor.


short-chain collagen trimer

description: Any collagen trimer that does not form fibrils and that is relatively short compared to the collagen trimers that do form fibrils.


name: procollagen-proline 4-dioxygenase complex, alpha(II) type

description: A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type II isoform; its activity is inhibited by poly(L-proline) only at high concentrations.


TACC/TOG complex

description: A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase.


Holliday junction helicase complex

description: A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA.


name: methylthiol:coenzyme M methyltransferase complex

description: A protein complex of two polypeptides which catalyzes the transfer of methyl group from methylthiol to coenzyme M during methanogenesis.


laminin-9 complex

description: A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains.


sucrase-isomaltase complex

description: A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities.


NOXA-BCL-2 complex

description: A heterodimeric protein complex consisting of NOXA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.


H-NS-Cnu complex

description: A trimeric protein complex containing a H-NS homodimer and a Cnu monomer. In bacteria, this complex negatively regulates transcription of a range of genes.


Cbp3p-Cbp6 complex

description: A protein complex located at the mitochondrial ribosome tunnel exit that is involved in efficient translation and protein complex assembly.


glutamate decarboxylase complex

description: A protein complex which is capable of glutamate decarboxylase activity.


name: sulfate adenylyltransferase complex (ATP)

description: An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP.


S100A8 complex

description: A protein complex composed of a S100A8 dimer and capable of binding to toll-like receptor 4 (TLR4).


DNA polymerase complex

description: A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA.


name: RNA polymerase V transcription repressor complex

description: A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase V promoter.


retroviral intasome

description: A tetramer of retroviral integrase subunits tightly associated with a pair of viral DNA ends. Functions to insert viral DNA into a host cell chromosome.


PKM2 pyruvate kinase complex

description: A protein complex capable of pyruvate kinase activity. PKM2 only exists as homotetramer when bound to beta-d-fructofuranose 1,6-bisphosphate (CHEBI:28013).


name: box C/D methylation guide scaRNP complex

description: A ribonucleoprotein complex containing a small CB-specific RNA (scaRNA), with a short sequence motif (GU/UG wobble stem) for CB localization that is capable of methylation of target RNAs.


glucosidase complex

description: A protein complex which is capable of glucosidase activity.


ecdysone receptor holocomplex

description: A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes.


alpha6-beta4 integrin-CD9 complex

description: A protein complex that consists of an alpha6-beta4 integrin complex bound to the cell surface protein CD9.


CENP-T-W-S-X complex

description: A histone-variant containing protein complex which forms a centromere specific nucleosome-like structure, involved in centromeric chromatin organization.


IKKalpha-IKKalpha complex

description: A homodimeric protein complex containing two IkappaB kinase (IKK) alpha subunits.


name: plasma membrane-derived thylakoid photosystem II

description: A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone.


translation initiation complex

description: A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.


PTEN phosphatase complex

description: A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function.


description: A protein complex that is involved in the transfer of the second mannose to the glycosylphosphatidylinositol (GPI) during GPI precursor assembly. In yeast S. cerevisiae this complex consists of GPI18p and PGA1p.


core primosome complex

description: A protein-DNA complex containing at least one DNA helicase and one primase. Can also contain associated proteins. The helicase component continues to unwind the double-stranded DNA (dsDNA) and the primase component synthesizes a RNA primer during initiation or restart of replication.


name: glycerol-3-phosphate dehydrogenase (FAD) complex

description: An enzyme complex that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate, with concurrent reduction of flavin adenine dinucleotide (FAD) to FADH2. In E. coli, the complex is either a GlpA-GlpB-GlpC heterotrimer that functions in anaerobic conditions, or a GlpD homodimer that functions in aerobic conditions.


description: A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface protein CD47 and the low-affinity immunoglobulin epsilon Fc receptor (FCER2).


iRhom2/ADAM17 sheddase complex

description: A complex consisting of ADAM17 in complex with regulatory iRhoms and FERM domain containing proteins.


EDS1 disease-resistance complex

description: A plant complex involved in basal disease resistance and resistance (R) gene-mediated effector triggered immunity (ETI). Regulates accumulation of the hormone salicylic acid (SA) which is a necessary component of systemic immunity. Involved in responds to bacteria, viruses and oomycetes.


Smp focus

description: A DNA-binding ribonucleoprotein complex that contains a lncRNA complementary to the bound chromosomal locus and is involved in the tethering homologous chromosomes together during chromosome pairing at meiotic prophase I.


actin cytoskeleton-regulatory complex

description: A protein complex probably required for the internalization of endosomes during actin-coupled endocytosis. Links the site of endocytosis to the cell membrane-associated actin cytoskeleton, coordinating ARP2/3 stimulation at the later stages of endocytosis. Present in the late endocytic coat.


dosage compensation complex

description: A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes.


name: acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex

description: A multifunctional enzyme complex composed of five different polypeptides that catalyzes the decarbonylation of acetyl-CoA, cleaves the C-C and C-S bonds in the acetyl moiety of acetyl-CoA, oxidizes the carbonyl group to CO2 and transfers the methyl group to tetrahydrosarcinapterin. These reactions are important for methanogenesis.


box C/D RNP complex

description: A ribonucleoprotein complex consisting of a box C/D type snRNA and three (Archaea) or four (Eukaryotes) core proteins that have diverse functions, including site-specific methylation of rRNA and processing rRNA.


name: insulin control element activator complex

description: Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription.


DNA polymerase V complex

description: A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis.


name: PSI associated light-harvesting complex I, LHCIb subcomplex

description: A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm.


invertasome

description: A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts.


viral integration complex

description: A nucleoprotein complex containing viral genetic material and the viral integrase, required for genome integration into the host's genome. May contain other proteins.


G-protein beta/gamma-Raf-1 complex

description: A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein.


MECO complex

description: A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II.


name: DNA polymerase III, clamp loader complex

description: A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands.


mannan polymerase II complex

description: A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p, Anp1p, Mnn10p, Mnn11p, and Hoc1p.


name: endoplasmic reticulum protein-containing complex

description: A protein complex that is part of an endoplasmic reticulum.


Tpg-containing telomere binding complex

description: A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species.


metallochaperone complex

description: A protein complex which is capable of metallochaperone activity.


Cdc24p-Far1p-Gbetagamma complex

description: A complex that forms at the cell cortex in response to pheromone treatment and is required for the polarized growth of haploid yeast cells towards a mating partner during yeast mating. In the yeast Saccharomyces cerevisiae, this complex consists of Cdc24p, Far1p, Ste4p (G-protein beta subunit) and Ste18p (G-protein gamma subunit).


acyl-CoA ceramide synthase complex

description: A protein complex that catalyzes the reaction acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae it contains three subunits: lag1, lac1 and lip1.


description: A protein complex capable of catalysing the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the histidine residue of translation elongation factor 2 (EF2), which is the first step in the biosynthesis of diphthamide. The complex is a Dph2 homodimer in archaea and a Dph1-Dph2 heterodimer in eukaryotes.


DNA helicase complex

description: A protein complex that possesses DNA helicase activity.


description: A protein complex that consists of an alpha5-beta1 integrin complex bound to osteopontin.


description: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane.


PAK family kinase-Sog2 complex

description: A protein kinase complex comprising a conserved PAK/GC/Ste20 family kinase, leucine rich repeat protein Sog2 family, which function as part of the cell shape network.


description: A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters.


Nicalin-NOMO complex

description: A protein complex regulating Nodal signaling. Subunits are highly conserved in vertebrates and include Nicalin, NOMO and TMEM147.


MAML3-RBP-Jkappa-ICN2 complex

description: A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling.


MAML2-RBP-Jkappa-ICN1 complex

description: A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.


collagen type XIX trimer

description: A collagen homotrimer of alpha1(XIX) chains; type XIX collagen triple helices localize to basement membrane zones in differentiating muscle cells.


name: type III protein secretion system complex

description: A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase.


enzyme IIA-maltose transporter complex

description: A protein complex consisting of the pentameric maltose transporter complex bound to two enzyme IIA (EIIA) molecules. EIIA is a component of the glucose-specific phosphotransferase system that inhibits maltose transport from the periplasm to the cytoplasm. When EIIA-bound, the maltose transporter remains in the open, inward-facing conformation, which prevents binding of maltose-loaded maltose binding protein (MBP) to the transporter.


mannan polymerase complex

description: A protein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins.


polarisome

description: Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p.


interleukin-10 receptor complex

description: A protein complex that binds interleukin-10 (IL-10) and that consists of, at a minimum, a dimeric interleukin, an alpha and a beta chain as well as optional additional kinase subunits. The alpha chain binds IL-10 with high affinity and subsequently binds the common beta receptor chain that forms part of multiple interleukin receptors.


subtelomeric heterochromatin

description: Heterochromatin that is located adjacent to the telomere, and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3).


alphaV-beta3 integrin-gelsolin complex

description: A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin.


viral terminase, small subunit

description: The part of the viral terminase complex that acts as a phage DNA-recognition component and regulates the activity of the large subunit. The small subunit usually assembles as a heterooligomer with the large subunit.


BIM-BCL-xl complex

description: A heterodimeric protein complex consisting of BIM and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.


name: platelet-derived growth factor receptor-ligand complex

description: A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes.


creatine kinase complex

description: A protein complex having creatine kinase activity.


Gemin6-Gemin7-unrip complex

description: A protein complex that contains Gemin6, Gemin7, and unrip (STRAP), and can bind to snRNAs; may play a role in snRNP assembly.


ADPG pyrophosphorylase complex

description: Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits.


PDX1-PBX1b-MRG1 complex

description: A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes.


name: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

description: A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.


MUB1-RAD6-UBR2 ubiquitin ligase complex

description: A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme.


interferon regulatory factor 7 complex

description: An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 7.


name: CUE1-UBC7 ubiquitin-conjugating enzyme complex

description: A protein complex capable of ubiquitin-conjugating enzyme activity during ER-associated protein degradation (ERAD). In S. cerevisiae, UBC7 is the ubiquitin-conjugating enzyme (E2) and requires binding to the ER surface by CUE1.


Mei2 nuclear dot complex

description: A ribonucleoprotein complex that forms during meiotic prophase in a fixed position in the horsetail nucleus; contains Mei2 and meiRNA. May play a role in the progression of meiosis I.


FHL2-CREB complex

description: A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation.


name: type VI protein secretion system complex

description: A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence.


name: large latent transforming growth factor-beta complex

description: A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors.


pyroptosome complex

description: A protein complex that consists of an assemble of ASC dimers that is capable of inducing pyroptosis.


Ost-alpha/Ost-beta complex

description: A heterodimeric protein complex composed of Ost-alpha/SLC51A and Ost-beta/SLC51B subunits and involved in bile acid transport activity.


cytosolic proteasome core complex

description: The core complex of a proteasome located in the cytosol of a cell.


ethanolamine ammonia-lyase complex

description: An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia.


VRK3/VHR/ERK complex

description: A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway.


name: cytosolic proteasome regulatory particle, lid subcomplex

description: The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.


Gemin3-Gemin4-Gemin5 complex

description: A protein complex that contains Gemin3 (DDX20), Gemin4, and Gemin5, and can bind to snRNAs; may be an intermediate in SMN complex assembly.


name: DNA polymerase III, clamp loader chi/psi subcomplex

description: A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III clamp loader complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB).


polyprenyl diphosphate synthase complex

description: A complex that possesses polyprenyl diphosphate synthase activity involved in the synthesis of the isoprenoid chain of ubiquinone whose length varies between organisms.


alpha4-beta1 integrin-JAM2 complex

description: A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2.


name: procollagen-proline 4-dioxygenase complex, alpha(I) type

description: A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type I isoform; its activity is readily inhibited by poly(L-proline).


U11 snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U11, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U11 snRNP, most of which remain associated with the U11 snRNA both while the U11 snRNP is free or assembled into a series of spliceosomal complexes.


name: alpha7-beta1 integrin-laminin alpha-2 complex

description: A protein complex that consists of an alpha7-beta1 integrin complex bound to laminin alpha-2.


polyphosphate kinase complex

description: A protein complex that possesses polyphosphate kinase activity.


alpha9-beta1 integrin-ADAM12 complex

description: A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12.


FtsQBL complex

description: A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB, FtsL and FtsQ.


bacterial pre-replicative complex

description: A protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.


taurine dioxygenase complex

description: A protein complex capable of catalyzing the conversion of taurine and alpha-ketoglutarate to sulfite, aminoacetaldehyde and succinate under sulfur or cysteine starvation conditions. Its expression is repressed by the presence of sulfate or cysteine. In E. coli it is a homodimer or homotetramer of the protein TauD.


PTEX complex

description: A protein complex that acts as a protein trafficking machinery and is responsible for the export of proteins across the parasitophorous (symbiont-containing) vacuolar membrane and into the human host cell. The PTEX complex is located in the vacuole membrane. It is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a parasite protein termed PTEX150, and exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components.


MalFGK2 complex

description: Protein complex involved in maltose transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of a cytoplasmic ATPase MalK homodimer together with a heterodimeric transmembrane subunit MalF-MalG.


collagen type XVIII trimer

description: A collagen homotrimer of alpha1(XVIII) chains.


protein-DNA-RNA complex

description: A macromolecular complex containing protein, DNA, and RNA molecules.


FAL1-SGD1 complex

description: A protein complex involved in the 18S rRNA biogenesis. In S. cerevisiae this complex consists of Fal1p and Sgd1p and in humans this complex consists of NOM1 and eIF4AIII subunits.


interferon regulatory factor 3 complex

description: An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 3.


interleukin-1 receptor complex

description: A protein complex that binds interleukin-1; comprises an alpha and a beta subunit.


high-affinity iron permease complex

description: A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


alpha4-beta1 integrin-CD82 complex

description: A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD82, a member of the tetraspan family.


type V protein secretion system complex

description: A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc).


MIM complex

description: A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. MIM constitutes the major integration site for alpha-helical embedded proteins. In yeast, consists oof Mim1 and Mim2.


Yae1-Lto1 complex

description: A cytosolic complex that functions as an substrate-specific adaptor, linking the cytosolic iron-sulfur protein assembly (CIA) targeting complex to apo-Rli1p, an ABC protein involved in ribosome recycling, facilitating Fe-S cluster insertion and the maturation of the Rli1p.


cellular bud neck polarisome

description: Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis.


SCF-Ctf13 ubiquitin ligase complex

description: An SCF ubiquitin ligase complex in which the F-box protein is Ctf13 in S. cerevisiae.


cysteine synthase complex

description: Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A.


transcription factor TFIIIC2 complex

description: A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter.


SCF-Ucc1 ubiquitin ligase complex

description: An SCF ubiquitin ligase complex in which the F-box protein is YLR224W in S. cerevisiae.


myosin IX complex

description: A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins.


translation preinitiation complex

description: A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA.


Sid2-Mob1 complex

description: A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex.


name: formyl-methanofuran dehydrogenase (tungsten enzyme) complex

description: A protein complex consisting of four polypeptides which also contains tungsten, a molybdopterin guanine dinucleotide, and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis.


name: sodium ion-transporting F-type ATPase complex

description: A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism.


H-NS-Hha complex

description: A trimeric protein complex made up of an H-NS homodimer and an Hha monomer. In Enterobacteriaceae, this complex negatively regulates transcription of a range of genes.


name: silver ion transmembrane transporter complex

description: A protein complex which is capable of silver ion transmembrane transporter activity.


alphaM-beta2 integrin-CD63 complex

description: A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family.


name: alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex

description: A protein complex that consists of an alphaIIb-beta3 integrin complex bound to fibronectin and tissue transglutaminase.


SCF-Rcy1/Pof6 ubiquitin ligase complex

description: An SCF ubiquitin ligase complex in which the F-box protein is Rcy1 in S. cerevisiae (Pof6 in S. pombe).


plastid large ribosomal subunit

description: The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).


description: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane.


viral terminase complex

description: A complex of a large and small subunit which catalyze the packaging of DNA into viral heads. Note that not all viral terminases have this structure, some exist as single polypeptides.


nonsense-mediated decay complex

description: A highly conserved protein complex that recognises and elicits the rapid degradation of mRNAs in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.


description: Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits.


IgZ immunoglobulin complex

description: A protein complex composed of two identical immunoglobulin heavy chains of the IgZ isotype and two identical immunoglobulin light chains, held together by disulfide bonds. The IgZ isotype is also known as the IgT isotype in certain species of fish.


pre-B cell receptor complex

description: An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.


name: CoB-CoM heterodisulfide reductase complex

description: A protein complex that in Methanobacterium thermoautotrophicum is composed of six subunits, and in Methanosarcina barkeri contains is composed of either two subunits or nine subunits. Catalyzes the conversion of coenzyme B, coenzyme M, and methanophenazine to form N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine and dihydromethanophenazine.


5-lipoxygenase complex

description: An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity.


NVT complex

description: A protein complex that is capable of contributing to protein localization by the NVT pathway. In fission yeast, the Nvt complex consists of Ape2, Lap2 and Nbr1.


DnaA-DnaB-DnaC complex

description: A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC bound to the DNA-bound DNA replication initiation protein DnaA. Essential for DNA replication initiation.


collagen type XVII trimer

description: A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices span the plasma membrane and associate with hemidesmosomes and the basal lamina where they bind laminin.


heparanase complex

description: A protein complex which is capable of heparanase activity.


Rvs161p-Rvs167p complex

description: A protein complex that is involved in endocytosis in the yeast S. cerevisiae.


description: A protein complex that consists of an alpha5-beta1 integrin complex bound to endostatin, the NC1 domain of the alpha1 chain of type XVIII collagen.


Tec1p-Ste12p-Dig1p complex

description: A multiprotein complex that is involved in the transcriptional regulation of primarily filamentation genes, but also mating genes, in the yeast S. cerevisiae.


Kibra-Ex-Mer complex

description: An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2.


name: tRNA-specific adenosine-34 deaminase complex

description: A protein complex that possesses tRNA-specific adenosine-34 deaminase activity. In eukaryotes the complex is a heterodimer; the subunits are known as Tad2p and Tad3p in yeasts and Adat2 and Adat3 in human.


DNA replication factor C core complex

description: A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37.


photosystem II antenna complex

description: The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs).


XRCC2-RAD51D complex

description: A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast.


name: PSII associated light-harvesting complex II

description: Protein-pigment complex associated with photosystem II.


G-protein alpha(13)-synembrin complex

description: A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(13) subunit of a heterotrimeric G protein.


alpha3-beta1 integrin-basigin complex

description: A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin.


phosphatase complex

description: A protein complex which is capable of phosphatase activity.


Bam protein complex

description: Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex.


plasma membrane respirasome

description: A respiratory chain located in the plasma membrane of a cell; made up of the protein complexes that form the electron transport system (the respiratory chain), associated with the plasma membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.


description: A protein complex that is part of a mitochondrion.


description: An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine.


Hedgehog signaling complex

description: A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila).


PAT complex

description: A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the correct folding of multipass membrane proteins in the ER membrane. In human, the substrate-binding Asterix (PAT10, WDR83OS) forms an obligate heterodimer with CCDC47.


description: A protein complex that contains two cell adhesion molecules, a protocadherin-alpha and a protocadherin-gamma, and is involved in the regulation of protein localization to the plasma membrane.


name: plasma membrane proton-transporting V-type ATPase, V1 domain

description: The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane.


phenylacetyl-CoA 1,2-epoxidase complex

description: A protein complex capable of catalysing the reaction: phenylacetyl-CoA + H+ + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+.


name: plasma membrane light-harvesting complex

description: A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species.


ERMES complex

description: A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles.


ProVWX complex

description: The ProVWX complex belongs to the family of ATP-binding cassette (ABC) transporter proteins complexes. It consists of a cytoplasmic ATPase subunit ProV, a transmembrane subunit ProW and a periplasmic binding protein ProX. It is capable of translocating a wide variety of solute (e.g. glycine betaine) across the plasma membrane and is activated under osmotic stress conditions.


interleukin-35 complex

description: A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space.


name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex

description: A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, Rab3a, and complexin II (or orthologs thereof).


alpha5-beta1 integrin-LPP3 complex

description: A protein complex that consists of an alpha5-beta1 integrin complex bound to lipid phosphate phosphohydrolase-3.


Doa10p ubiquitin ligase complex

description: A multiprotein complex that recognizes and ubiquitinates membrane proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p.


nuclear proteasome regulatory particle

description: The regulatory subcomplex of a proteasome located in the nucleus of a cell.


name: chloroplast proton-transporting ATP synthase complex, coupling factor CF(o)

description: All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins.


Rpd3S complex

description: A eukaryotically conserved histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species).


description: A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof).


light-harvesting complex, core complex

description: Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria.


BAD-BCL-xl complex

description: A heterodimeric protein complex consisting of BAD and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.


name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex

description: A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt2p.


name: mitotic checkpoint complex, CDC20-MAD2 subcomplex

description: A protein complex involved in the spindle checkpoint, preventing the activation of the anaphase-promoting complex until all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle. In budding yeast this complex consists of Mad2p and Cdc20p, and in mammalian cells it consists of MAD2 and CDC20.


myosin phosphatase complex

description: An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin. Composed of a PP1 catalytic subunit (PP1c/PPP1CB) and a myosin phosphatase targeting subunit (MYPT1/PPP1R12A).


tubulin folding cofactor complex

description: A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur.


glutamate synthase complex

description: A complex that possesses glutamate synthase activity.


sarcosine oxidase complex

description: A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity.


Shc-Grb2-Sos complex

description: A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.


BCL-2 complex

description: A homodimeric protein complex consisting of BCL-2, a member of the Bcl-2 family of anti- and proapoptotic regulators.


name: light-harvesting complex, peripheral complex

description: Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center.


ferredoxin hydrogenase complex

description: An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances.


name: low-density lipoprotein receptor complex

description: A plasma membrane protein complex capable of low-density lipoprotein particle receptor activity. It may also bind xenobiotic toxins and deliver them into the cell via endocytosis. While most substrates get degraded via the endosome the receptor is recycled to the plasma membrane. It may also act as a transducer of intracellular signal pathways and often acts in corporation with other cell-surface receptors.


description: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane.


mitochondrial creatine kinase complex

description: An octomeric protein complex having creatine kinase activity.


name: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)

description: A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present.


phycobilisome

description: Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II.


description: Complex that possesses imidazoleglycerol-phosphate synthase activity.


name: cytosolic electron transfer flavoprotein complex

description: A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors.


galectin lattice

description: A non-stoichiometric protein complex formed by several galectins crosslinking glycosylated ligands to form a dynamic lattice. The galectin lattice modulates receptor kinase signaling and the functionality of membrane receptors, by regulating the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids.


sheet-forming collagen trimer

description: A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers assemble into a sheet.


DNA methyltransferase complex

description: A protein complex that possesses DNA methyltransferase activity.


Cdc50p-Drs2p complex

description: A protein complex that functions as a phospholipid-translocating P-Type ATPase. In budding yeast, this complex consists of Cdc50p and Drs2p proteins, and is involved in the trafficking of transport vesicles between the late Golgi and the early endosome.


nuclear SCF ubiquitin ligase complex

description: A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).


name: procollagen-proline 4-dioxygenase complex, alpha(III) type

description: A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type III isoform.


SUMO-targeted ubiquitin ligase complex

description: A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes.


name: sodium ion-transporting V-type ATPase complex

description: A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis.


laminin-6 complex

description: A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains.


chloroplast large ribosomal subunit

description: The large subunit of a ribosome contained within a chloroplast.


DNA polymerase III, core complex

description: The DNA polymerase III core complex consists of the alpha,epsilon and theta subunits and is carries out the polymerase and the 3'-5' exonuclease proofreading activities.


alphaPDGFR-SHP-2 complex

description: A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.


description: A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin.


name: alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex

description: A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase.


name: single-stranded DNA-dependent ATP-dependent DNA helicase complex

description: A protein complex that possesses single-stranded DNA-dependent DNA helicase activity.


name: TAF4B-containing transcription factor TFIID complex

description: A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4.


radial spoke 2

description: The radial spoke of each group of radial spokes, whether grouped as triplets or doublets, that is immediately distal to radial spoke 1 (RS1). Radial spoke 2 (RS2), similarly to RS1, is comprised of four domains: 1) a very short base anchored to the A microtubule, 2) an elongaged stalk, 3) a bifurcated neck, and 4) an orthogonal head. The base of RS2 is connected to the tail of the inner dynein arm c.


aspartate carbamoyltransferase complex

description: A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides.


description: A protein complex involved in the disassembly and subsequent reassembly of nucleosomes. It associates with the coding region of transcriptionally active genes where it interacts with the RNA polymerase II and affects its processivity during co-transcriptional RNA processing and maturation. It exists as a functionally independent part of the NuA4 complex.


CENP-A containing chromatin

description: The specialized chromatin located in the centromeric core region or the entire centromeric region in organisms with point centromeres, which is enriched for CENP-A-containing nucleosomes. This chromatin forms a 3-dimensional structure which provides a platform for kinetochore assembly and microtubule attachment.


translocon complex

description: A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins.


[Ni-Fe] hydrogenase complex

description: A microbial enzyme complex which contains nickel and iron in its active site. In Acetomicrobium flavidum it is an alpha 2 beta 2 tetramer.


alpha4-beta1 integrin-paxillin complex

description: A protein complex that consists of an alpha4-beta1 integrin complex bound to paxillin.


name: RNA polymerase III transcription regulator complex

description: A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase III.


name: cytoplasmic origin of replication recognition complex

description: A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm.


FACIT collagen trimer

description: A collagen trimer that associates with collagen fibrils and consists of collagen monomers that contain two or more relatively short triple-helical domains connected by non-triple-helical sequences.


name: ornithine carbamoyltransferase inhibitor complex

description: A protein complex which is capable of ornithine carbamoyltransferase inhibitor activity.


box H/ACA RNP complex

description: A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex.


collagen type XXII trimer

description: A collagen homotrimer of alpha1(XXII) chains; type XXII collagen triple helices acts as a cell adhesion ligand for skin epithelial cells and fibroblasts.


viral transcriptional complex

description: Specific locations and structures in the virus infected cell involved in transcribing the viral genome.


name: alpha11-beta1 integrin-collagen type I complex

description: A protein complex that consists of an alpha11-beta1 integrin complex bound to a type I collagen.


sulfurtransferase complex

description: A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor).


extracellular exosome complex

description: A protein complex that is wholly or partially contained within the lumen or membrane of the extracellular vesicular exosome.


name: alphav-beta3 integrin-collagen alpha3(VI) complex

description: A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen.


membrane fusion priming complex

description: A protein complex that primes vacuolar or vesicular membranes for fusion with other intracellular membranes, by promoting the dissociation of cis-SNARE complexes.


DNA recombinase mediator complex

description: A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange.


name: proton-transporting V-type ATPase, V1 domain

description: A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A.


NADH dehydrogenase complex

description: An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.


endonuclease complex

description: A protein complex which is capable of endonuclease activity.


myosin VIII complex

description: A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain.


mitotic septin complex

description: A heterooligomeric septin complex that acts during mitotic cell division.


Rad51B-Rad51C complex

description: A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof.


bacterial-type flagellum stator complex

description: A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species.


CBF3 complex

description: A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p.


EmrE multidrug transporter complex

description: A transmembrane protein complex capable of transporting positively charged hydrophobic drugs across the plasma membrane thereby involved in conferring resistance to a wide range of toxic compounds (e.g. methyl viologen, ethidium bromide and acriflavine). It is commonly found in bacteria. In E. coli it forms a homodimer.


name: RNA polymerase I upstream activating factor complex

description: A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p.


name: small ribosomal subunit processing complex

description: A small heterodimeric protein complex that is required during early maturation of nascent 40S ribosomal subunits. The complex has endonuclease activity, it interacts with the small ribosomal subunit pre-rRNA and cleave it it to produce the mature 18S (or small ribosomal subunit) rRNA. In S. cerevisiae it is composed of Rcl1p and Bms1p.


Noc complex

description: Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis.


SCF-Das1 ubiquitin ligase complex

description: An SCF ubiquitin ligase complex in which the F-box protein is Das1 in S. cerevisiae.


U12 snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U12, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U12 snRNP, most of which remain associated with the U12 snRNA both while the U12 snRNP is free or assembled into a series of spliceosomal complexes.


MIH complex

description: A trimeric complex involved in cytokinesis. Proposed to bridge actomyosin ring contraction and septum synthesis in yeast, resulting in the coordination of these processes, and leading to plasma membrane ingression and fusion. In the yeast Saccharomyces cerevisiae this complex consists of Mlc1p, Iqg1p and Hof1p proteins.


description: A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin.


radial spoke base 1

description: The short portion of the radial spoke 1 (RS1) that is directly anchored to the A microtubule of an axonemal microtubule doublet.


photosystem II

description: A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center.


BRE1 E3 ubiquitin ligase complex

description: A homodimeric protein complex composed of the E3 ubiquitin-protein ligase BRE1. Plays a role in regulating association of RNA polymerase II with active genes.


intraciliary transport particle

description: A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.


SL snRNP

description: A ribonucleoprotein complex that contains spliced leader (SL) RNA and associated proteins.


thrombospondin complex

description: A homotrimeric or homopentameric glycoprotein that functions at the interface of the cell membrane and the extracellular matrix through its interactions with proteins and proteoglycans, such as collagens, integrins and fibronectin, to regulate matrix structure and cellular behaviour.


Asi complex

description: A nuclear ubiquitin ligase multiprotein complex located in the inner nuclear membrane (INM) that recognizes and ubiquitinates misfolded INM proteins and also some proteins involved in sterol biosynthesis, during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligases Asi1p and Asi3p.


Tor2-Mei2-Ste11 complex

description: A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast.


DNA helicase A complex

description: A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction.


photosystem

description: A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species.


FMN reductase complex

description: A protein complex capable of FMN reductase activity. Reduces FMN to FMNH2 in a NAD(P)H-dependent manner. In E.coli, consists of a SsuE dimer.


name: DNA polymerase III, proofreading complex

description: A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity.


mating-type region heterochromatin

description: Heterochromatic regions of the chromosome found at silenced mating-type loci.


ATP-dependent citrate lyase complex

description: A protein complex that catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA.


fatty acid synthase complex

description: A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA.


intercalary heterochromatin

description: Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes.


alpha9-beta1 integrin-ADAM2 complex

description: A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM2.


description: A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV.


upstream stimulatory factor complex

description: A protein complex capable of sequence-specific DNA binding RNA polymerase II transcription factor activity through binding to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3'). Found in a variety of viral and cellular promoters.


SCF-Skp2 ubiquitin ligase complex

description: An SCF ubiquitin ligase complex in which the F-box protein is Skp2 in S. cerevisiae.


description: A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof).


RNA polymerase II termination complex

description: A conserved protein complex capable of 5'-3' exoribonuclease activity. It is able to promote RNA polymerase II (RNAPII) transcription termination by degrading pre-mRNA from the newly formed 5' phosphorylated end.


Nsk1-Dlc1 complex

description: A dimer of Nsk1 (nucleolus spindle kinetochore 1) and the dynein light chain, Dlc1. The dimers form an oligomeric chain structure. Functions in the regulation of kinetochore-microtubule interactions and chromosome segregation.


name: ATP-binding cassette (ABC) transporter complex, integrated substrate binding

description: A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a half transporter. Two half-transporters come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.


collagen type XXV trimer

description: A collagen homotrimer of alpha1(XXV) chains; type XXV collagen triple helices span the plasma membrane.


myosin VI complex

description: A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments.


chloroplast photosystem I

description: Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana.


name: type II site-specific deoxyribonuclease complex

description: A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell.


aminodeoxychorismate synthase complex

description: A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity.


xylanosome

description: A multifunctional supermolecular complex, containing several proteins with hemicellulase activity. Functions to hydrolyze hemicellulose.


alphaV-beta6 integrin-TGFbeta-3 complex

description: A protein complex that consists of an alphaV-beta6 integrin complex bound to transforming growth factor beta-3 (TGFbeta-3).


Fc-gamma receptor I complex

description: A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG.


myosin XVIII complex

description: A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain.


methane monooxygenase complex

description: A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized.


Fc-alpha receptor I complex

description: A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA.


name: alpha3-beta1 integrin-tissue transglutaminase complex

description: A protein complex that consists of an alpha3-beta1 integrin complex bound to tissue transglutaminase.


myosin XII complex

description: A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil.


chloroplast outer membrane translocon

description: The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner.


Ste12p-Dig1p-Dig2p complex

description: A multiprotein complex that is involved in the transcription regulation of mating genes in the yeast S. cerevisiae.


name: cell envelope Sec protein transport complex

description: A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC.


MdtBC Complex

description: A protein complex containing two transmembrane subunits; a MdtB dimer and one unit of MdtC. Capable of exporting substrates across the cell membrane. Involved in conferring antibiotic resistance of Gram-negative bacteria by transporting drugs across the membrane.


Ecsit-NDUFAF1 complex

description: Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed.


EFF-1 complex

description: A trimeric cell-cell fusion complex that serves as a scaffold for zippering up the extracellular domains, bringing the transmembrane segments into close proximity such that they can continue zippering within the two membranes into one. Two prefusion monomers cluster at the surface of adjacent cells. Parallel EFF-1 interactions occur across cells and a third monomer, which can come from either cell, adds on to make an intermediate, extended trimer.


Snt2C complex

description: A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p.


divisome complex

description: A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). These complexes are assembled and recruited to the cell septum in a strictly controlled sequence and co-ordinate invagination of the cell membrane, inward growth of the peptidoglycan layer, constriction of the outer membrane and separation of daughter cells.


toxin-antitoxin complex

description: A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon.


type IV secretion system complex

description: A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s).


transforming growth factor beta complex

description: A protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerization and dissociation of the LAP.


description: A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin.


description: A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.


D-amino-acid dehydrogenase complex

description: A protein complex that possesses D-amino-acid dehydrogenase activity.


name: methionine-importing ABC transporter complex

description: An ATP-binding cassette (ABC) transporter complex that is capable of methionine-importing activity. An example is the bacterial MetNIQ methionine transporter, that consists of the dimeric ATPase subunit MetN located at the cytoplasmic side of the plasma membrane and the dimeric transmembrane subunit MetI. MetQ is regarded as the periplasmic methionine-binding chaperon subunit, and is capable of transporting methionine from the periplasm into the cytoplasm in an ATP-dependent manner.


telomere cap complex

description: A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome.


clathrin coat of synaptic vesicle

description: A clathrin coat found on a synaptic vesicle.


name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex

description: A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt4p.


name: inositol phosphoceramide synthase complex

description: A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces).


name: hemidesmosome associated protein complex

description: Any protein complex that is part of or has some part in a hemidesmosome.


Fc receptor complex

description: A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin.


IgW immunoglobulin complex

description: A protein complex composed of two identical immunoglobulin heavy chains of the IgW isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgW immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.


protein phosphatase inhibitor complex

description: A protein-containing complex that inhibits protein phosphatase activity by directly binding to a protein phosphatase.


activator ecdysone receptor complex

description: A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes.


name: transferase complex, transferring phosphorus-containing groups

description: A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).


description: A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity.


Delta1 complex

description: A protein complex that consists of homodimer of the Notch ligand Delta1.


description: A protein complex that consists of an alpha3-beta1 integrin complex bound to thrombospondin.


superoxide dismutase complex

description: A protein complex which is capable of superoxide dismutase activity.


IgA B cell receptor complex

description: An IgA immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.


laminin-7 complex

description: A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains.


ERBB4-EGFR complex

description: A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and epidermal growth factor receptor (EGFR/ERBB1).


interleukin-20 receptor complex

description: A protein complex composed of an alpha and a beta receptor subunit and an interleukin ligand. In human, Interleukin-19, -20 and -24 bind IL20RA/IL20RB receptor subunits and Interleukin-20 and -24 bind IL22RA1/IL20RB receptor subunits.


TBK1-IKKE-DDX3 complex

description: A protein complex containing TBK1 (TANK-binding kinase 1), IKBKE (I-Kappa-B kinase epsilon/IKKE/IKK-epsilon) and the DEAD box family RNA helicase DDX3.


translation repressor complex

description: A protein complex which is capable of translation repressor activity.


name: cytosolic proteasome regulatory particle

description: A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex.


IgA immunoglobulin complex, circulating

description: A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.


glutathione synthase complex

description: A protein complex composed of two or more polypeptide subunits, and which possesses glutathione synthase activity (catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate). In eukaryotes, the complex is homodimeric, in E. coli glutathione synthase exists as a tetramer, and in S. pombe the complex exists as a homodimer or a heterotetramer.


description: A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin.


name: condensed chromatin of inactivated sex chromosome

description: A condensed form of chromatin that is associated with an inactivated sex chromosome and which is responsible for its inactivation.


name: formyl-methanofuran dehydrogenase (molybdenum enzyme) complex

description: A protein complex consisting of three polypeptides which also contains molybdenum, a molybdopterin guanine dinucleotide and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis.


name: phosphatidylinositol 3-kinase complex, class I

description: A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast.


protein-carbohydrate complex

description: A macromolecular complex containing separate protein and carbohydrate molecules. Separate in this context means not covalently bound to each other.


RPB4-RPB7 complex

description: A protein complex that cycles between the nucleus where it is part of the RNA polymerase II and the cytoplasmic mRNA processing body where it mediates the two major cytoplasmic mRNA decay pathways.