name: regulation of short-term neuronal synaptic plasticity

description: A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.


dendritic spine membrane

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The portion of the plasma membrane surrounding a dendritic spine.


ionotropic glutamate receptor complex

description: A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex.


name: ZN879_HUMAN Zinc finger protein 879 (sprot)

description: A zinc finger protein 879 that is encoded in the genome of human.


name: ZN736_HUMAN Zinc finger protein 736 (sprot)

description: A zinc finger protein 736 that is encoded in the genome of human.


name: ZN732_HUMAN Zinc finger protein 732 (sprot)

description: A zinc finger protein 732 that is encoded in the genome of human.


name: S31C2_HUMAN Putative spermatogenesis-associated protein 31C2 (sprot)


name: GGTL3_HUMAN Putative glutathione hydrolase light chain 3 (sprot)


glutathione hydrolase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate.


glutathione catabolic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.


name: EIFCL_HUMAN Eukaryotic translation initiation factor 3 subunit C-like protein (sprot)

description: A eukaryotic translation initiation factor 3 subunit C-like protein that is encoded in the genome of human.


name: formation of cytoplasmic translation initiation complex

description: Joining of the large ribosomal subunit with the translation preinitiation complex, with release of IF2/eIF2 and IF3/eIF3 or IF5B/eIF5B. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.


eukaryotic 43S preinitiation complex

description: A protein complex composed of the 40S ribosomal subunit plus eIF1, eIF1A, eIF3, eIF5, and eIF2-GTP-bound methionyl-initiator methionine tRNA.


eukaryotic 48S preinitiation complex

description: The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC.


name: TARM1_HUMAN T-cell-interacting, activating receptor on myeloid cells protein 1 (sprot)

description: A T-cell-interacting, activating receptor on myeloid cells protein 1 that is encoded in the genome of human.


immunoglobulin receptor binding

description: Binding to one or more specific sites on an immunoglobulin receptor molecule.


name: negative regulation of CD4-positive, alpha-beta T cell activation

description: Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation.


specific granule membrane

description: The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.


tertiary granule membrane

description: The lipid bilayer surrounding a tertiary granule.


name: ERVV1_HUMAN Endogenous retrovirus group V member 1 Env polyprotein (sprot)

description: An endogenous retrovirus group V member 1 Env polyprotein that is encoded in the genome of human.


name: ERVV2_HUMAN Endogenous retrovirus group V member 2 Env polyprotein (sprot)

description: An endogenous retrovirus group V member 2 Env polyprotein that is encoded in the genome of human.


name: KCJ18_HUMAN Inward rectifier potassium channel 18 (sprot)

description: An inward rectifier potassium channel 18 that is encoded in the genome of human.


name: inward rectifier potassium channel activity

description: Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.


name: ZN814_HUMAN Zinc finger protein 814 (sprot)

description: A zinc finger protein 814 that is encoded in the genome of human.


name: TRDC_HUMAN T cell receptor delta constant (sprot)

description: A T cell receptor delta constant that is encoded in the genome of human.


gamma-delta T cell activation

description: The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


gamma-delta T cell receptor complex

description: A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein.


name: GPHRA_HUMAN Golgi pH regulator A (sprot)

description: A Golgi pH regulator A that is encoded in the genome of human.


name: voltage-gated monoatomic anion channel activity

description: Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


T cell differentiation

description: The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.


name: positive regulation of canonical NF-kappaB signal transduction

description: Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade.


intracellular pH reduction

description: Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.


name: monoatomic anion transmembrane transport

description: The process in which a monoatomic anion is transported across a membrane. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom.


Golgi-associated vesicle membrane

description: The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.


Golgi cisterna membrane

description: The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex.


name: PP13G_HUMAN Protein phosphatase 1 regulatory subunit 3G (sprot)

description: A protein phosphatase 1 regulatory subunit 3G that is encoded in the genome of human.


glycogen biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.


glucose homeostasis

description: Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.


name: positive regulation of glycogen biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.


name: KIF28_HUMAN Kinesin-like protein KIF28P (sprot)

description: A protein that is a translation product of the KIF28P gene in human.


mitochondrion organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.


organelle transport along microtubule

description: The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.


name: B7ZLF3_HUMAN C2H2-type domain-containing protein (trembl)


name: F243A_HUMAN Uncharacterized protein C21orf140 (sprot)

description: A protein that is a translation product of the C21orf140 gene in human.


name: IGLL5_HUMAN Immunoglobulin lambda-like polypeptide 5 (sprot)

description: An immunoglobulin lambda-like polypeptide 5 that is encoded in the genome of human.


name: TBC3L_HUMAN TBC1 domain family member 3L (sprot)

description: A protein that is a translation product of the TBC1D3L gene in human.


name: T150C_HUMAN Transmembrane protein 150C (sprot)

description: A transmembrane protein 150C that is encoded in the genome of human.


name: mechanosensitive monoatomic ion channel activity

description: Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress.


proprioception

description: The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors.


name: cellular response to mechanical stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.


name: OSCRI_HUMAN SCRIB overlapping open reading frame protein (sprot)


name: negative regulation of translational initiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.


name: SEHBP_HUMAN Transcriptional regulator SEHBP (sprot)


histone binding

description: Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.


name: MP31_HUMAN PTEN upstream open reading frame MP31 (sprot)


lactate oxidation

description: The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons.


HAS3P_HUMAN HOXB-AS3 peptide (sprot)

A protein that is a translation product of the HOXB-AS3 gene in human.


name: negative regulation of pre-miRNA processing

description: Any process that stops, prevents or reduces the frequency, rate or extent of pre-microRNA processing.


name: RBRP_HUMAN Putative RNA-binding regulatory peptide (sprot)


mRNA stabilization

description: Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules.


positive regulation of mRNA binding

description: Any process that activates or increases the frequency, rate or extent of mRNA binding.


name: PKHUO_HUMAN PRKCH upstream open reading frame 2 (sprot)


name: protein serine/threonine kinase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase.


translation regulator activity

description: Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.


protein serine/threonine kinase binding

description: Binding to a protein serine/threonine kinase.


name: positive regulation of translation in response to stress

description: Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress.


name: cellular response to amino acid starvation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.


name: negative regulation of protein serine/threonine kinase activity

description: Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.


name: DDUP_HUMAN DNA damage up-regulated protein (sprot)

description: A protein that is a translation product of the CTBP1-DT gene in human.


recombinational repair

description: A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.


postreplication repair

description: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication.


name: P155_HUMAN HSPA8-interacting micropeptide miPEP155 (sprot)

description: A protein that is a translation product of the MIR155HG gene in human.


Hsp70 protein binding

description: Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.


name: negative regulation of dendritic cell antigen processing and presentation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation.


name: WASH3_HUMAN Putative WAS protein family homolog 3 (sprot)

description: A putative WAS protein family homolog 3 that is encoded in the genome of human.


protein targeting to lysosome

description: The process of directing proteins towards the lysosome using signals contained within the protein.


endosome organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.


name: AJM1_HUMAN Apical junction component 1 homolog (sprot)

description: An apical junction component 1 homolog that is encoded in the genome of human.


name: TR49D_HUMAN Tripartite motif-containing protein 49D (sprot)

description: A tripartite motif-containing protein 49D that is encoded in the genome of human.


name: U17LF_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 15 (sprot)

description: A protein that is a translation product of the USP17L15 gene in human.


name: TEX22_HUMAN Testis-expressed protein 22 (sprot)

description: A testis-expressed protein 22 that is encoded in the genome of human.


name: RAS4B_HUMAN Ras GTPase-activating protein 4B (sprot)

description: A protein that is a translation product of the RASA4B gene in human.


name: negative regulation of Ras protein signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.


cellular response to calcium ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.


name: UMAD1_HUMAN UBAP1-MVB12-associated (UMA)-domain containing protein 1 (sprot)

description: A protein that is a translation product of the UMAD1 gene in human.


name: KRBX1_HUMAN KRAB domain-containing protein 1 (sprot)

description: A KRAB domain-containing protein 1 that is encoded in the genome of human.


name: HSBPL_HUMAN Heat shock factor-binding protein 1-like protein 1 (sprot)

description: A heat shock factor-binding protein 1-like protein 1 that is encoded in the genome of human.


transcription corepressor activity

description: A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.


tight junction

description: A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.


name: PATL2_HUMAN Protein PAT1 homolog 2 (sprot)

description: A protein PAT1 homolog 2 that is encoded in the genome of human.


name: NPIB4_HUMAN Nuclear pore complex-interacting protein family member B4 (sprot)

description: A protein that is a translation product of the NPIPB4 gene in human.


name: PRRT4_HUMAN Proline-rich transmembrane protein 4 (sprot)

description: A proline-rich transmembrane protein 4 that is encoded in the genome of human.


name: TM238_HUMAN Transmembrane protein 238 (sprot)

description: A transmembrane protein 238 that is encoded in the genome of human.


name: U17LA_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 10 (sprot)

description: A protein that is a translation product of the USP17L10 gene in human.


name: HHLA1_HUMAN HERV-H LTR-associating protein 1 (sprot)

description: A HERV-H LTR-associating protein 1 that is encoded in the genome of human.


name: U17LD_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 13 (sprot)

description: A protein that is a translation product of the USP17L13 gene in human.


name: ZFTA_HUMAN Zinc finger translocation-associated protein (sprot)

description: A zinc finger translocation-associated protein that is encoded in the genome of human.


name: MCRI1_HUMAN Mapk-regulated corepressor-interacting protein 1 (sprot)

description: A Mapk-regulated corepressor-interacting protein 1 that is encoded in the genome of human.


name: regulation of epithelial to mesenchymal transition

description: Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


cytoplasmic stress granule

description: A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.


name: ZN878_HUMAN Zinc finger protein 878 (sprot)

description: A zinc finger protein 878 that is encoded in the genome of human.


name: UL17C_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 12 (sprot)

description: A protein that is a translation product of the USP17L12 gene in human.


name: TM232_HUMAN Transmembrane protein 232 (sprot)

description: A transmembrane protein 232 that is encoded in the genome of human.


maintenance of protein complex location

description: Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away.


name: spermatid cytoplasm removal during spermiation of flagellated sperm

description: The process of removing the majority of the cytoplasm and organelles from a spermatid as it develops into a mature flagellated sperm cell.


outer dense fiber

description: A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins.


name: KBTBD_HUMAN Kelch repeat and BTB domain-containing protein 13 (sprot)

description: A kelch repeat and BTB domain-containing protein 13 that is encoded in the genome of human.


name: regulation of the force of skeletal muscle contraction

description: Any process that modulates the frequency, rate or extent of the force of skeletal muscle contraction. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through the formation of cross bridges.


relaxation of skeletal muscle

description: A process in which the extent of skeletal muscle tissue contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases.


name: AK1BF_HUMAN Aldo-keto reductase family 1 member B15 (sprot)

description: An aldo-keto reductase family 1 member B15 that is encoded in the genome of human.


name: estradiol 17-beta-dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor.


name: testosterone 17-beta-dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione.


allyl-alcohol dehydrogenase activity

description: Catalysis of the reaction: allyl alcohol + NADP+ = acrolein + H+ + NADPH.


farnesol dehydrogenase activity

description: Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP+ = 2-trans,6-trans-farnesal + H+ + NADPH.


name: all-trans-retinol dehydrogenase (NADP+) activity

description: Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.


estrogen biosynthetic process

description: The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.


retinol metabolic process

description: The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.


name: MEIOS_HUMAN Meiosis initiator protein (sprot)

description: A meiosis initiator protein that is encoded in the genome of human.


cellular response to retinoic acid

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.


activation of meiosis

description: Any process that starts the inactive process of meiosis.


name: ADM5_HUMAN Putative adrenomedullin-5-like protein (sprot)

description: A protein that is a translation product of the ADM5 gene in human.


name: U17LB_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 11 (sprot)

description: A protein that is a translation product of the USP17L11 gene in human.


name: INAM1_HUMAN Putative transmembrane protein INAFM1 (sprot)

description: A protein that is a translation product of the INAFM1 gene in human.


FREY_HUMAN Protein Frey 1 (sprot)

A protein Frey 1 that is encoded in the genome of human.


name: maintenance of protein localization in endoplasmic reticulum

description: Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum.


name: SIM47_HUMAN Small integral membrane protein 47 (sprot)

description: A protein that is a translation product of the SMIM47 gene in human.


name: PRAC2_HUMAN Putative protein PRAC2 (sprot)


name: KLRF2_HUMAN Killer cell lectin-like receptor subfamily F member 2 (sprot)

description: A killer cell lectin-like receptor subfamily F member 2 that is encoded in the genome of human.


natural killer cell degranulation

description: The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell.


name: U17LL_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 21 (sprot)

description: A protein that is a translation product of the USP17L21 gene in human.


name: U17LI_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 18 (sprot)

description: A protein that is a translation product of the USP17L18 gene in human.


name: U17LM_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 22 (sprot)

description: A protein that is a translation product of the USP17L22 gene in human.


name: U17LN_HUMAN Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23 (sprot)


name: U17LH_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 17 (sprot)

description: A protein that is a translation product of the USP17L17 gene in human.


name: U17LJ_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 19 (sprot)

description: A protein that is a translation product of the USP17L19 gene in human.


name: CFA99_HUMAN Cilia- and flagella-associated protein 99 (sprot)

description: A protein that is a translation product of the CFAP99 gene in human.


MCIN_HUMAN Multicilin (sprot)

A multicilin that is encoded in the genome of human.


name: regulation of DNA-templated DNA replication initiation

description: Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.


centriole assembly

description: A cellular process that results in the assembly of one or more centrioles.


name: multi-ciliated epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.


nuclear body

description: Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.


name: U17LK_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 20 (sprot)

description: A protein that is a translation product of the USP17L20 gene in human.


name: STMP1_HUMAN Short transmembrane mitochondrial protein 1 (sprot)

description: A protein that is a translation product of the STMP1 gene in human.


name: mitochondrial respiratory chain complex III assembly

description: The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane.


mitochondrial respirasome assembly

description: The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex.


name: positive regulation of NLRP3 inflammasome complex assembly

description: Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly.


mitochondrial intermembrane space

description: The region between the inner and outer lipid bilayers of the mitochondrial envelope.


MUC22_HUMAN Mucin-22 (sprot)

A mucin-22 that is encoded in the genome of human.


PBMU2_HUMAN Protein PBMUCL2 (sprot)

A protein PBMUCL2 that is encoded in the genome of human.


name: PRS46_HUMAN Putative serine protease 46 (sprot)

description: A protein that is a translation product of the PRSS46P gene in human.


name: NPB11_HUMAN Nuclear pore complex-interacting protein family member B11 (sprot)

description: A protein that is a translation product of the NPIPB11 gene in human.


name: FONG_HUMAN Formiminotransferase N-terminal subdomain-containing protein (sprot)

description: A protein that is a translation product of the FTCDNL1 gene in human.


transferase activity

description: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.


name: RN223_HUMAN RING finger protein 223 (sprot)

description: A RING finger protein 223 that is encoded in the genome of human.


name: Z587B_HUMAN Zinc finger protein 587B (sprot)

description: A zinc finger protein 587B that is encoded in the genome of human.


name: PROB1_HUMAN Proline-rich basic protein 1 (sprot)

description: A proline-rich basic protein 1 that is encoded in the genome of human.


name: NACAM_HUMAN Nascent polypeptide-associated complex subunit alpha, muscle-specific form (sprot)

description: A nascent polypeptide-associated complex subunit alpha, muscle-specific form (human), isoforms h1 and h2.


nascent polypeptide-associated complex

description: A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.


name: P23D1_HUMAN Proline-rich protein 23D1 (sprot)

description: A protein that is a translation product of the PRR23D1 gene in human.


name: NPIA7_HUMAN Nuclear pore complex-interacting protein family member A7 (sprot)

description: A protein that is a translation product of the NPIPA7 gene in human.


name: E9PQ42_HUMAN TMEM276-ZFTRAF1 readthrough (Fragment) (trembl)


name: NDUCR_HUMAN NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2 (sprot)

description: A chimeric protein that is a readthrough translation product of the human NDUFC2 and KCTD14 genes.


name: mitochondrial electron transport, NADH to ubiquinone

description: The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation.


name: TM262_HUMAN Cation channel sperm-associated auxiliary subunit TMEM262 (sprot)

description: A protein that is a translation product of the TMEM262 gene in human.


name: FND10_HUMAN Fibronectin type III domain-containing protein 10 (sprot)

description: A fibronectin type III domain-containing protein 10 that is encoded in the genome of human.


name: SO1BT_HUMAN SLCO1B3-SLCO1B7 readthrough transcript protein (sprot)


smooth endoplasmic reticulum membrane

description: The lipid bilayer surrounding the smooth endoplasmic reticulum.


name: CC080_HUMAN Uncharacterized membrane protein C3orf80 (sprot)

description: An uncharacterized membrane protein C3orf80 that is encoded in the genome of human.


name: APRIO_HUMAN Alternative prion protein (sprot)


name: RFAL1_HUMAN Ret finger protein-like 4A-like protein 1 (sprot)

description: A protein that is a translation product of the RFPL4AL1 gene in human.


name: NPB12_HUMAN Nuclear pore complex-interacting protein family member B12 (sprot)

description: A protein that is a translation product of the NPIPB12 gene in human.


INSR2_HUMAN Insulin, isoform 2 (sprot)

A chimeric protein that is a readthrough translation product of the human INS and IGF2 genes.


name: SUMO5_HUMAN Small ubiquitin-related modifier 5 (sprot)


transcription factor binding

description: Binding to a transcription factor, a protein required to initiate or regulate transcription.


protein sumoylation

description: The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.


PML body organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia).


name: SO1B7_HUMAN Putative solute carrier organic anion transporter family member 1B7 (sprot)


name: KR416_HUMAN Putative keratin-associated protein 4-16 (sprot)


name: CNIPF_HUMAN CNK3/IPCEF1 fusion protein (sprot)


name: positive regulation of cellular response to hepatocyte growth factor stimulus

description: Any process that activates or increases the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus.


FA72C_HUMAN Protein FAM72C (sprot)

A protein that is a translation product of the FAM72C gene in human.


name: PRA26_HUMAN PRAME family member 26 (sprot)

description: A protein that is a translation product of the PRAMEF26 gene in human.


name: TM250_HUMAN Transmembrane protein 250 (sprot)

description: A protein that is a translation product of the TMEM250 gene in human.


positive regulation of viral process

description: Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant.


name: CC084_HUMAN Uncharacterized protein C3orf84 (sprot)

description: A protein that is a translation product of the C3orf84 gene in human.


name: LY6L_HUMAN Lymphocyte antigen 6L (sprot)

description: A lymphocyte antigen 6L that is encoded in the genome of human.


side of membrane

description: A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface.


name: SMLR1_HUMAN Small leucine-rich protein 1 (sprot)

description: A protein that is a translation product of the SMLR1 gene in human.


name: PIRC2_HUMAN Piercer of microtubule wall 2 protein (sprot)

description: A protein that is a translation product of the PIERCE2 gene in human.


name: H3BU10_HUMAN Uncharacterized protein (trembl)


name: CC179_HUMAN Coiled-coil domain-containing protein 179 (sprot)

description: A coiled-coil domain-containing protein 179 that is encoded in the genome of human.


name: TGR3L_HUMAN Transforming growth factor-beta receptor type 3-like protein (sprot)

description: A transforming growth factor-beta receptor type 3-like protein that is encoded in the genome of human.


CLD34_HUMAN Claudin-34 (sprot)

A protein that is a translation product of the CLDN34 gene in human.


name: CC188_HUMAN Coiled-coil domain-containing protein 188 (sprot)

description: A protein that is a translation product of the CCDC188 gene in human.


name: PANO1_HUMAN Proapoptotic nucleolar protein 1 (sprot)

description: A protein that is a translation product of the PANO1 gene in human.


regulation of protein stability

description: Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.


name: TRI77_HUMAN Tripartite motif-containing protein 77 (sprot)

description: A protein that is a translation product of the TRIM77 gene in human.


name: CS084_HUMAN Uncharacterized protein C19orf84 (sprot)

description: An uncharacterized protein C19orf84 that is encoded in the genome of human.


name: GFY_HUMAN Golgi-associated olfactory signaling regulator (sprot)

description: A Golgi-associated olfactory signaling regulator that is encoded in the genome of human.


name: protein localization to non-motile cilium

description: A process in which a protein is transported to, or maintained in, a location within a non-motile cilium.


non-motile cilium assembly

description: The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium.


name: CCER2_HUMAN Coiled-coil domain-containing glutamate-rich protein 2 (sprot)

description: A protein that is a translation product of the CCER2 gene in human.


name: SIM22_HUMAN Small integral membrane protein 22 (sprot)

description: A protein that is a translation product of the SMIM22 gene in human.


name: regulation of cell population proliferation

description: Any process that modulates the frequency, rate or extent of cell proliferation.


IFNL4_HUMAN Interferon lambda-4 (sprot)

A protein that is a translation product of the IFNL4 gene in human.


cytokine activity

description: The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells.


name: tyrosine phosphorylation of STAT protein

description: The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


name: type III interferon-mediated signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by type III interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon lambda is the only member of the type III interferon found so far.


positive regulation of immune response

description: Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.


name: S35U4_HUMAN SLC35A4 upstream open reading frame protein (sprot)


name: ASURF_HUMAN ASNSD1 upstream open reading frame protein (sprot)


RPAP3/R2TP/prefoldin-like complex

description: A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity.


name: MIDUO_HUMAN Mitochondrial ribosome and complex I assembly factor AltMIEF1 (sprot)


name: mitochondrial large ribosomal subunit binding

description: Binding to a mitochondrial large ribosomal subunit.


mitochondrial fission

description: The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.


name: positive regulation of mitochondrial translation

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.


name: mitochondrial large ribosomal subunit assembly

description: The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit.


name: RN225_HUMAN RING finger protein 225 (sprot)

description: A RING finger protein 225 that is encoded in the genome of human.


name: M0QZD8_HUMAN Vitellogenin domain-containing protein (trembl)


lipid transporter activity

description: Enables the directed movement of lipids into, out of or within a cell, or between cells.


name: DCDC1_HUMAN Doublecortin domain-containing protein 1 (sprot)

description: A doublecortin domain-containing protein 1 that is encoded in the genome of human.


regulation of mitotic cytokinesis

description: Any process that modulates the frequency, rate or extent of mitotic cytokinesis.


SUPYN_HUMAN Suppressyn (sprot)

A protein that is a translation product of the ERVH48-1 gene in human.


syncytium formation

description: The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division.


name: OVOL3_HUMAN Putative transcription factor ovo-like protein 3 (sprot)

description: A putative transcription factor ovo-like protein 3 that is encoded in the genome of human.


A deoxyribonuclease-2-alpha that is encoded in the genome of human.


enucleate erythrocyte differentiation

description: The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus.


lysosome

description: A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.


name: ADAS_HUMAN Alkyldihydroxyacetonephosphate synthase, peroxisomal (sprot)

description: An alkyldihydroxyacetonephosphate synthase, peroxisomal that is encoded in the genome of human.


lipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.


description: Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion.


FAD binding

description: Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.


peroxisomal membrane

description: The lipid bilayer surrounding a peroxisome.


name: UBXN8_HUMAN UBX domain-containing protein 8 (sprot)

description: A UBX domain-containing protein 8 that is encoded in the genome of human.


ubiquitin ligase complex

description: A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.


name: KIF2A_HUMAN Kinesin-like protein KIF2A (sprot)

description: A kinesin-like protein KIF2A that is encoded in the genome of human.


spindle microtubule

description: Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.


cytoskeletal motor activity

description: Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).


microtubule depolymerization

description: The removal of tubulin heterodimers from one or both ends of a microtubule.


mitotic spindle organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.


mitotic spindle assembly

description: Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied.


centriolar subdistal appendage

description: A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68.


name: SGK1_HUMAN Serine/threonine-protein kinase Sgk1 (sprot)

description: A serine/threonine-protein kinase Sgk1 that is encoded in the genome of human.


name: protein serine/threonine kinase activity

description: Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.


name: protein serine/threonine/tyrosine kinase activity

description: Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.


calcium channel regulator activity

description: Modulates the activity of a calcium channel.


potassium channel regulator activity

description: Binds to and modulates the activity of a potassium channel.


sodium channel regulator activity

description: Binds to and modulates the activity of a sodium channel.


chloride channel regulator activity

description: Binds to and modulates the activity of a chloride channel.


regulation of cell growth

description: Any process that modulates the frequency, rate, extent or direction of cell growth.


protein phosphorylation

description: The process of introducing a phosphate group on to a protein.


sodium ion transport

description: The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


long-term memory

description: The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.


regulation of blood pressure

description: Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.


name: positive regulation of transporter activity

description: Any process that activates or increases the activity of a transporter.


regulation of apoptotic process

description: Any process that modulates the occurrence or rate of cell death by apoptotic process.


regulation of catalytic activity

description: Any process that modulates the activity of an enzyme.


name: regulation of DNA-binding transcription factor activity

description: Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.


regulation of gastric acid secretion

description: Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.


renal sodium ion absorption

description: A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.


name: regulation of signal transduction by p53 class mediator

description: Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.


cellular response to aldosterone

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus.


nuclear speck

description: A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.


name: KITM_HUMAN Thymidine kinase 2, mitochondrial (sprot)

description: A thymidine kinase 2, mitochondrial that is encoded in the genome of human.


deoxycytidine kinase activity

description: Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.


thymidine kinase activity

description: Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.


nucleoside kinase activity

description: Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate.


name: nucleobase-containing compound metabolic process

description: Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.


name: deoxyribonucleoside monophosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.


nucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).


pyrimidine nucleoside salvage

description: Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis.


deoxycytidine metabolic process

description: The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.


thymidine metabolic process

description: The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.


DNA biosynthetic process

description: The biosynthetic process resulting in the formation of DNA.


FZD9_HUMAN Frizzled-9 (sprot)

A frizzled-9 that is encoded in the genome of human.


Wnt receptor activity

description: Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.


ossification

description: The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.


name: release of cytochrome c from mitochondria

description: The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.


neuroblast proliferation

description: The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.


learning or memory

description: The acquisition and processing of information and/or the storage and retrieval of this information over time.


B cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.


name: positive regulation of bone mineralization

description: Any process that activates or increases the frequency, rate or extent of bone mineralization.


name: negative regulation of neuron apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.


name: negative regulation of mitochondrial depolarization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.


name: negative regulation of necroptotic process

description: Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.


name: positive regulation of canonical Wnt signaling pathway

description: Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


postsynapse organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.


name: negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.


name: regulation of skeletal muscle acetylcholine-gated channel clustering

description: Any process that modulates the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering.


name: negative regulation of skeletal muscle acetylcholine-gated channel clustering

description: Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering.


bone regeneration

description: The regrowth of bone following its loss or destruction.


filopodium membrane

description: The portion of the plasma membrane surrounding a filopodium.


postsynapse

description: The part of a synapse that is part of the post-synaptic cell.


name: DX39A_HUMAN ATP-dependent RNA helicase DDX39A (sprot)

description: An ATP-dependent RNA helicase DDX39 that is encoded in the genome of human.


mRNA splicing, via spliceosome

description: The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.


RNA export from nucleus

description: The directed movement of RNA from the nucleus to the cytoplasm.


mRNA export from nucleus

description: The directed movement of mRNA from the nucleus to the cytoplasm.


name: PDLI1_HUMAN PDZ and LIM domain protein 1 (sprot)

description: A PDZ and LIM domain protein 1 that is encoded in the genome of human.


name: cadherin binding involved in cell-cell adhesion

description: Any cadherin binding that occurs as part of the process of cell-cell adhesion.


fibroblast migration

description: Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.


maintenance of cell polarity

description: The maintenance of established anisotropic intracellular organization or cell growth patterns.


actin cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.


name: establishment or maintenance of actin cytoskeleton polarity

description: Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures.


stress fiber assembly

description: The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.


cell-cell adhesion

description: The attachment of one cell to another cell via adhesion molecules.


name: BACH_HUMAN Cytosolic acyl coenzyme A thioester hydrolase (sprot)

description: A cytosolic acyl coenzyme A thioester hydrolase that is encoded in the genome of human.


fatty-acyl-CoA binding

description: Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.


long-chain fatty acyl-CoA binding

description: Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


carboxylic ester hydrolase activity

description: Catalysis of the hydrolysis of a carboxylic ester bond.


name: long-chain fatty acyl-CoA hydrolase activity

description: Catalysis of the reaction: a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


coenzyme A biosynthetic process

description: The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.


name: long-chain fatty-acyl-CoA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


name: medium-chain fatty acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.


palmitic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of palmitic acid.


name: GPR25_HUMAN Probable G-protein coupled receptor 25 (sprot)

description: A probable G-protein coupled receptor 25 that is encoded in the genome of human.


name: MYO1C_HUMAN Unconventional myosin-Ic (sprot)

description: A myosin-Ic that is encoded in the genome of human.


protein targeting to membrane

description: The process of directing proteins towards a membrane, usually using signals contained within the protein.


vesicle transport along actin filament

description: Movement of a vesicle along an actin filament, mediated by motor proteins.


name: positive regulation of cellular response to insulin stimulus

description: Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus.


name: regulation of bicellular tight junction assembly

description: Any process that modulates the frequency, rate or extent of tight junction assembly.


basal plasma membrane

description: The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.


lateral plasma membrane

description: The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.


phagocytic vesicle

description: A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.


name: MYO1F_HUMAN Unconventional myosin-If (sprot)

description: A myosin-If that is encoded in the genome of human.


name: SNP23_HUMAN Synaptosomal-associated protein 23 (sprot)

description: A synaptosomal-associated protein 23 that is encoded in the genome of human.


syntaxin binding

description: Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.


histamine secretion by mast cell

description: The regulated release of histamine by a mast cell or group of mast cells.


post-Golgi vesicle-mediated transport

description: The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.


vesicle targeting

description: The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo.


membrane fusion

description: The membrane organization process that joins two lipid bilayers to form a single membrane.


specific granule

description: Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.


azurophil granule

description: Primary lysosomal granule readily stainable with a Romanowsky stain.


presynapse

description: The part of a synapse that is part of the presynaptic cell.


SNARE complex

description: A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.


name: HAX1_HUMAN HCLS1-associated protein X-1 (sprot)

description: An HCLS1-associated protein X-1 that is encoded in the genome of human.


interleukin-1 binding

description: Binding to interleukin-1.


signaling adaptor activity

description: The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.


name: regulation of actin filament polymerization

description: Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.


name: positive regulation of granulocyte differentiation

description: Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.


name: granulocyte colony-stimulating factor signaling pathway

description: The series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R).


name: positive regulation of peptidyl-tyrosine phosphorylation

description: Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.


name: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

description: Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction.


cellular response to cytokine stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.


name: regulation of autophagy of mitochondrion

description: Any process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process.


name: regulation of protein targeting to mitochondrion

description: Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion.


name: EYA2_HUMAN Eyes absent homolog 2 (sprot)

description: An eyes absent homolog 2 that is encoded in the genome of human.


histone H2AXY142 phosphatase activity

description: Catalysis of the reaction: histone H2AX tyrosine phosphate (position 142) + H2O = histone H2AX tyrosine (position 142) + phosphate.


DNA repair

description: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.


mesodermal cell fate specification

description: The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


striated muscle tissue development

description: The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.


name: extrinsic apoptotic signaling pathway in absence of ligand

description: The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.


name: mitochondrial outer membrane permeabilization

description: The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.


PLM_HUMAN Phospholemman (sprot)

A phospholemman that is encoded in the genome of human.


potassium ion transport

description: The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


chloride transport

description: The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


muscle contraction

description: A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.


regulation of heart contraction

description: Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.


name: negative regulation of protein glutathionylation

description: Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.


name: regulation of cardiac muscle cell membrane potential

description: Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


name: positive regulation of sodium ion export across plasma membrane

description: Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane.


name: regulation of sodium ion transmembrane transporter activity

description: Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.


caveola

description: A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.


intercalated disc

description: A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.


T-tubule

description: Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.


description: Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.


name: AIP_HUMAN AH receptor-interacting protein (sprot)

description: An AH receptor-interacting protein that is encoded in the genome of human.


name: peptidyl-prolyl cis-trans isomerase activity

description: Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).


aryl hydrocarbon receptor binding

description: Binding to an aryl hydrocarbon receptor.


GAF domain binding

description: Binding to a GAF protein domain.


unfolded protein binding

description: Binding to an unfolded protein.


protein targeting to mitochondrion

description: The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.


name: regulation of protein kinase A signaling

description: Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.


protein maturation by protein folding

description: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein.


aryl hydrocarbon receptor complex

description: A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR.


name: CCL24_HUMAN C-C motif chemokine 24 (sprot)

description: A C-C motif chemokine 24 that is encoded in the genome of human.


chemokine activity

description: The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.


CCR3 chemokine receptor binding

description: Binding to a CCR3 chemokine receptor.


receptor ligand activity

description: The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same cell that expresses the receptor. Ligands may also be expressed at the plasma membrane of an adjacent cell (e.g. Notch ligands) or be secreted and diffuse extracellularly from their point of origin to the receiving cell (e.g. interleukins).


name: positive regulation of endothelial cell proliferation

description: Any process that activates or increases the rate or extent of endothelial cell proliferation.


chemotaxis

description: The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).


cell-cell signaling

description: Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.


name: positive regulation of actin filament polymerization

description: Any process that activates or increases the frequency, rate or extent of actin polymerization.


positive regulation of angiogenesis

description: Any process that activates or increases angiogenesis.


eosinophil chemotaxis

description: The movement of an eosinophil in response to an external stimulus.


name: positive regulation of eosinophil migration

description: Any process that activates or increases the frequency, rate or extent of eosinophil migration.


name: GTPB1_HUMAN GTP-binding protein 1 (sprot)

description: A GTP-binding protein 1 that is encoded in the genome of human.


translation elongation factor activity

description: Functions in chain elongation during polypeptide synthesis at the ribosome.


alpha-aminoacyl-tRNA binding

description: Binding to an alpha-aminoacyl-tRNA.


cytoplasmic translation

description: The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.


cytoplasmic exosome (RNase complex)

description: A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.


name: KCNK1_HUMAN Potassium channel subfamily K member 1 (sprot)

description: A potassium channel subfamily K member 1 that is encoded in the genome of human.


name: voltage-gated potassium channel activity

description: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


sodium channel activity

description: Enables the energy-independent facilitated diffusion of a sodium ion through a transmembrane aqueous pore or channel.


potassium ion leak channel activity

description: Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.


name: regulation of resting membrane potential

description: Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized.


brush border membrane

description: The portion of the plasma membrane surrounding the brush border.


synaptic membrane

description: A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.


voltage-gated potassium channel complex

description: A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.


potassium channel complex

description: An ion channel complex through which potassium ions pass.


name: inward rectifier potassium channel complex

description: A protein complex which is capable of inward rectifier potassium channel activity.


LEG9_HUMAN Galectin-9 (sprot)

A galectin-9 that is encoded in the genome of human.


regulation of interleukin-4 production

description: Any process that modulates the frequency, rate, or extent of interleukin-4 production.


regulation of interleukin-5 production

description: Any process that modulates the frequency, rate, or extent of interleukin-5 production.


toll-like receptor 2 signaling pathway

description: The series of molecular signals initiated by a ligand binding to toll-like receptor 2.


toll-like receptor 4 signaling pathway

description: The series of molecular signals initiated by a ligand binding to toll-like receptor 4.


name: mature conventional dendritic cell differentiation

description: The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells.


regulation of p38MAPK cascade

description: Any process that modulates the frequency, rate or extent of p38MAPK cascade.


galactose binding

description: Binding to aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides.


disaccharide binding

description: Binding to a disaccharide. Disaccharides are sugars composed of two monosaccharide units.


natural killer cell tolerance induction

description: Tolerance induction of natural killer cells.


female pregnancy

description: The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.


name: negative regulation of chemokine production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production.


name: negative regulation of tumor necrosis factor production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.


name: positive regulation of type II interferon production

description: Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.


name: positive regulation of interleukin-12 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.


name: positive regulation of interleukin-13 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.


name: positive regulation of interleukin-4 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.


name: positive regulation of interleukin-8 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.


name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

description: Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response.


p38MAPK cascade

description: A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.


name: negative regulation of mast cell degranulation

description: Any process that stops, prevents, or reduces the rate of mast cell degranulation.


name: negative regulation of natural killer cell mediated cytotoxicity

description: Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.


name: negative regulation of activated T cell proliferation

description: Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.


name: positive regulation of viral entry into host cell

description: Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell.


name: positive regulation of NF-kappaB transcription factor activity

description: Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.


name: positive regulation of activated T cell autonomous cell death

description: Any process that activates or increases the frequency, rate or extent of activated T cell autonomous cell death.


ERK1 and ERK2 cascade

description: A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development.


response to interleukin-1

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.


name: positive regulation of transforming growth factor beta production

description: Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta.


name: positive regulation of monocyte chemotactic protein-1 production

description: Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1.


name: positive regulation of non-canonical NF-kappaB signal transduction

description: Any process that activates or increases the frequency, rate or extent of the non-canonical NF-kappaB cascade.


name: positive regulation of dendritic cell chemotaxis

description: Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis.


name: negative regulation of CD4-positive, alpha-beta T cell proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation.


name: positive regulation of CD4-positive, alpha-beta T cell proliferation

description: Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation.


name: positive regulation of dendritic cell apoptotic process

description: Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process.


name: positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

description: Any process that activates or increases the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell.


name: positive regulation of dendritic cell differentiation

description: Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation.


name: positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

description: Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway.


name: STXB3_HUMAN Syntaxin-binding protein 3 (sprot)

description: A syntaxin-binding protein 3 that is encoded in the genome of human.


intracellular glucose homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of glucose within a cell.


protein to membrane docking

description: The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere.


insulin secretion

description: The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.


response to insulin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.


neutrophil degranulation

description: The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.


name: negative regulation of calcium ion-dependent exocytosis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis.


negative regulation of glucose import

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.


platelet aggregation

description: The adhesion of one platelet to one or more other platelets via adhesion molecules.


platelet alpha granule

description: A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).


tertiary granule

description: A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells.


name: MASP2_HUMAN Mannan-binding lectin serine protease 2 (sprot)

description: A mannan-binding lectin serine protease 2 that is encoded in the genome of human.


complement component C4b binding

description: Binding to a C4b product of the classical complement cascade.


complement activation, lectin pathway

description: Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.


name: complement activation, classical pathway

description: Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.


name: AP4M1_HUMAN AP-4 complex subunit mu-1 (sprot)

description: An AP-4 complex subunit mu-1 that is encoded in the genome of human.


name: protein transmembrane transporter activity

description: Enables the transfer of a protein from one side of a membrane to the other.


protein targeting

description: The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.


intracellular protein transport

description: The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.


Golgi to endosome transport

description: The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes.


protein transmembrane transport

description: The process in which a protein is transported across a membrane.


Golgi to lysosome transport

description: The directed movement of substances from the Golgi to lysosomes.


name: protein localization to basolateral plasma membrane

description: Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane.


AP-4 adaptor complex

description: An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo.


endosome lumen

description: The volume enclosed by the membrane of an endosome.


trans-Golgi network membrane

description: The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.


clathrin adaptor complex

description: A membrane coat adaptor complex that links clathrin to a membrane.


name: ARVC_HUMAN Splicing regulator ARVCF (sprot)

description: A splicing regulator ARVCF that is encoded in the genome of human.


SMAP_HUMAN Small acidic protein (sprot)

A small acidic protein that is encoded in the genome of human.


name: RB27B_HUMAN Ras-related protein Rab-27B (sprot)

description: A Ras-related protein Rab-27B that is encoded in the genome of human.


GDP binding

description: Binding to GDP, guanosine 5'-diphosphate.


myosin V binding

description: Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.


positive regulation of exocytosis

description: Any process that activates or increases the frequency, rate or extent of exocytosis.


synaptic vesicle endocytosis

description: A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.


multivesicular body sorting pathway

description: A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded.


anterograde axonal protein transport

description: The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons.


Golgi stack

description: The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.


trans-Golgi network transport vesicle

description: A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.


synaptic vesicle membrane

description: The lipid bilayer surrounding a synaptic vesicle.


platelet dense granule membrane

description: The lipid bilayer surrounding the platelet dense granule.


multivesicular body membrane

description: The lipid bilayer surrounding a multivesicular body.


axon cytoplasm

description: Any cytoplasm that is part of a axon.


name: HRK_HUMAN Activator of apoptosis harakiri (sprot)

description: An activator of apoptosis harakiri that is encoded in the genome of human.


name: positive regulation of release of cytochrome c from mitochondria

description: Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.


name: AP3B1_HUMAN AP-3 complex subunit beta-1 (sprot)

description: An AP-3 complex subunit beta-1 that is encoded in the genome of human.


protein phosphatase binding

description: Binding to a protein phosphatase.


GTP-dependent protein binding

description: Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state.


toll-like receptor signaling pathway

description: The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.


respiratory system process

description: A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.


intracellular zinc ion homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of zinc ions within a cell.


lysosome organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.


blood coagulation

description: The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.


anterograde axonal transport

description: The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.


granulocyte differentiation

description: The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.


melanosome organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.


protein localization to cell surface

description: A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.


name: clathrin-coated vesicle cargo loading, AP-3-mediated

description: Formation of a macromolecular complex between proteins of the AP-3 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. In some cases, the AP-3 complex is a heterotetrameric AP-type membrane coat adaptor complex that, in some organisms, links clathrin to the membrane surface of a vesicle.


mRNA transcription by RNA polymerase II

description: The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.


intracellular transport

description: The directed movement of substances within a cell.


name: antigen processing and presentation, exogenous lipid antigen via MHC class Ib

description: The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.


anterograde synaptic vesicle transport

description: The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse.


homeostasis of number of cells

description: Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.


name: positive regulation of NK T cell differentiation

description: Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation.


platelet dense granule organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins.


lung morphogenesis

description: The process in which the anatomical structures of the lung are generated and organized.


name: establishment of protein localization to mitochondrial membrane involved in mitochondrial fission

description: The directed movement of a protein to a specific location in the mitochondrial membrane that contributes to mitochondrial fission.


skin epidermis development

description: The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure.


melanosome assembly

description: The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.