name: RHBT3_HUMAN Rho-related BTB domain-containing protein 3 (sprot)

description: A Rho-related BTB domain-containing protein 3 that is encoded in the genome of human.


name: SO2B1_HUMAN Solute carrier organic anion transporter family member 2B1 (sprot)

description: A solute carrier organic anion transporter family member 2B1 that is encoded in the genome of human.


name: sodium-independent organic anion transmembrane transporter activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner.


heme catabolic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.


name: sodium-independent organic anion transport

description: The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: MTCL2_HUMAN Microtubule cross-linking factor 2 (sprot)

description: A microtubule cross-linking factor 2 that is encoded in the genome of human.


name: UBP19_HUMAN Ubiquitin carboxyl-terminal hydrolase 19 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 19 that is encoded in the genome of human.


name: negative regulation of skeletal muscle tissue development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.


name: positive regulation of cell cycle process

description: Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.


regulation of ERAD pathway

description: Any process that modulates the frequency, rate or extent of ERAD pathway.


name: WDR47_HUMAN WD repeat-containing protein 47 (sprot)

description: A WD repeat-containing protein 47 that is encoded in the genome of human.


name: cerebral cortex radial glia-guided migration

description: The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex.


corpus callosum development

description: The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.


motor behavior

description: The specific neuromuscular movement of a single organism in response to external or internal stimuli.


name: detection of hot stimulus involved in thermoception

description: The series of events in which a hot stimulus is received and converted into a molecular signal as part of thermoception.


name: TRI37_HUMAN E3 ubiquitin-protein ligase TRIM37 (sprot)

description: An E3 ubiquitin-protein ligase TRIM37 that is encoded in the genome of human.


name: histone H2AK119 ubiquitin ligase activity

description: Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-119 residue.


name: negative regulation of centriole replication

description: Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication.


name: AP2A2_HUMAN AP-2 complex subunit alpha-2 (sprot)

description: An AP-2 complex subunit alpha-2 that is encoded in the genome of human.


name: postsynaptic neurotransmitter receptor internalization

description: A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle.


AP-2 adaptor complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).


name: SC31A_HUMAN Protein transport protein Sec31A (sprot)

description: A protein transport protein Sec31A that is encoded in the genome of human.


vesicle coat

description: A membrane coat found on a coated vesicle.


name: CMTA2_HUMAN Calmodulin-binding transcription activator 2 (sprot)

description: A calmodulin-binding transcription activator 2 that is encoded in the genome of human.


CSTN1_HUMAN Calsyntenin-1 (sprot)

A calsyntenin-1 that is encoded in the genome of human.


X11-like protein binding

description: Binding to X11-like protein, a neuron-specific adaptor protein.


name: neurotransmitter receptor transport to postsynaptic membrane

description: The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles.


vesicle-mediated transport in synapse

description: Any vesicle-mediated transport that occurs in a synapse.


postsynaptic endosome

description: An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse.


name: CE152_HUMAN Centrosomal protein of 152 kDa (sprot)

description: A centrosomal protein of 152 kDa that is encoded in the genome of human.


FA13A_HUMAN Protein FAM13A (sprot)

A protein FAM13A that is encoded in the genome of human.


name: ARHGF_HUMAN Rho guanine nucleotide exchange factor 15 (sprot)

description: A Rho guanine nucleotide exchange factor 15 that is encoded in the genome of human.


regulation of postsynapse assembly

description: Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse.


name: negative regulation of synapse maturation

description: Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation.


name: SLIK5_HUMAN SLIT and NTRK-like protein 5 (sprot)

description: A SLIT and NTRK-like protein 5 that is encoded in the genome of human.


striatum development

description: The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.


circulatory system development

description: The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.


HEXI1_HUMAN Protein HEXIM1 (sprot)

A protein HEXIM1 that is encoded in the genome of human.


name: cyclin-dependent protein serine/threonine kinase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase.


snRNA binding

description: Binding to a small nuclear RNA (snRNA).


name: positive regulation of signal transduction by p53 class mediator

description: Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator.


7SK snRNP

description: A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb.


name: SOX30_HUMAN Transcription factor SOX-30 (sprot)

description: A transcription factor SOX-30 that is encoded in the genome of human.


response to corticosteroid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids.


proacrosomal vesicle fusion

description: Fusion of the membrane of proacrosomal vesicle with the membrane of another proacrosomal vesicle to form the acrosome.


name: OR2F2_HUMAN Olfactory receptor 2F2 (sprot)

description: An olfactory receptor 2F2 that is encoded in the genome of human.


name: OR6B1_HUMAN Olfactory receptor 6B1 (sprot)

description: An olfactory receptor 6B1 that is encoded in the genome of human.


name: O4F21_HUMAN Olfactory receptor 4F21 (sprot)

description: An olfactory receptor 4F21 that is encoded in the genome of human.


name: UPP2_HUMAN Uridine phosphorylase 2 (sprot)

description: A uridine phosphorylase 2 that is encoded in the genome of human.


uridine phosphorylase activity

description: Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.


deoxyuridine phosphorylase activity

description: Catalysis of the reaction: 2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil.


uridine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.


dCMP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate.


UMP salvage

description: Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis.


uridine metabolic process

description: The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.


type III intermediate filament

description: A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments.


name: OR2A4_HUMAN Olfactory receptor 2A4 (sprot)

description: An olfactory receptor 2A4 that is encoded in the genome of human.


name: ZO3_HUMAN Tight junction protein ZO-3 (sprot)

description: A tight junction protein ZO-3 that is encoded in the genome of human.


name: INMT_HUMAN Indolethylamine N-methyltransferase (sprot)

description: An indolethylamine N-methyltransferase that is encoded in the genome of human.


thioether S-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.


amine N-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine.


description: Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine.


name: DIRA1_HUMAN GTP-binding protein Di-Ras1 (sprot)

description: A GTP-binding protein Di-Ras1 that is encoded in the genome of human.


name: RPP14_HUMAN Ribonuclease P protein subunit p14 (sprot)

description: A ribonuclease P protein subunit p14 that is encoded in the genome of human.


name: CCNB2_HUMAN G2/mitotic-specific cyclin-B2 (sprot)

description: A G2/mitotic-specific cyclin-B2 that is encoded in the genome of human.


name: KCNK2_HUMAN Potassium channel subfamily K member 2 (sprot)

description: A potassium channel subfamily K member 2 that is encoded in the genome of human.


name: outward rectifier potassium channel activity

description: Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force.


name: positive regulation of cellular response to hypoxia

description: Any process that activates or increases the frequency, rate or extent of cellular response to hypoxia.


astrocyte projection

description: A prolongation or process extending from the soma of an astrocyte and wrapping around neurons.


YIF1A_HUMAN Protein YIF1A (sprot)

A protein YIF1A that is encoded in the genome of human.


name: UBR5_HUMAN E3 ubiquitin-protein ligase UBR5 (sprot)

description: An E3 ubiquitin-protein ligase UBR5 that is encoded in the genome of human.


heterochromatin boundary formation

description: A process that forms a boundary that limits the spreading of heterochromatin along a chromosome.


progesterone receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A nuclear receptor-mediated signaling pathway initiated by a progesterone binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


name: cytoplasm protein quality control by the ubiquitin-proteasome system

description: The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation.


name: nuclear protein quality control by the ubiquitin-proteasome system

description: A protein quality control pathway that results in the breakdown of misfolded, damaged or unassembled proteins via a mechanism in which the proteins are ubiquitinated, and then targeted to nuclear proteasomes for degradation.


cytoplasm protein quality control

description: The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.


name: REC8_HUMAN Meiotic recombination protein REC8 homolog (sprot)

description: A meiotic recombination protein REC8 that is encoded in the genome of human.


seminiferous tubule development

description: The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa.


name: FSBP_HUMAN Fibrinogen silencer-binding protein (sprot)

description: A fibrinogen silencer-binding protein that is encoded in the genome of human.


name: ALX3_HUMAN Homeobox protein aristaless-like 3 (sprot)

description: A homeobox protein aristaless-like 3 that is encoded in the genome of human.


embryonic skeletal system morphogenesis

description: The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.


name: AGFG2_HUMAN Arf-GAP domain and FG repeat-containing protein 2 (sprot)

description: An Arf-GAP domain and FG repeat-containing protein 2 that is encoded in the genome of human.


PRS23_HUMAN Serine protease 23 (sprot)

A serine protease 23 that is encoded in the genome of human.


name: NKX22_HUMAN Homeobox protein Nkx-2.2 (sprot)

description: A homeobox protein Nkx-2.2 that is encoded in the genome of human.


pancreatic A cell fate commitment

description: The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.


type B pancreatic cell fate commitment

description: The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.


pancreatic PP cell fate commitment

description: The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.


name: spinal cord motor neuron differentiation

description: The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.


name: spinal cord oligodendrocyte cell fate specification

description: The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway.


optic nerve development

description: The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.


name: ventral spinal cord interneuron fate determination

description: The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron regardless of its environment; upon determination, the cell fate cannot be reversed. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses.


neuroendocrine cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance.


name: SCAF4_HUMAN SR-related and CTD-associated factor 4 (sprot)

description: An SR-related and CTD-associated factor 4 that is encoded in the genome of human.


name: RNA polymerase II C-terminal domain phosphoserine binding

description: Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II.


name: negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled

description: Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled.


name: ZN202_HUMAN Zinc finger protein 202 (sprot)

description: A zinc finger protein 202 that is encoded in the genome of human.


name: S1PR2_HUMAN Sphingosine 1-phosphate receptor 2 (sprot)

description: A sphingosine 1-phosphate receptor 2 that is encoded in the genome of human.


description: Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein.


name: negative regulation of excitatory postsynaptic potential

description: Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.


name: NDUB6_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 that is encoded in the genome of human.


MFN2_HUMAN Mitofusin-2 (sprot)

A mitofusin-2 that is encoded in the genome of human.


name: protein localization to phagophore assembly site

description: Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS).


mitochondrial membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.


camera-type eye morphogenesis

description: The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.


mitochondrion localization

description: Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell.


name: DUS14_HUMAN Dual specificity protein phosphatase 14 (sprot)

description: A dual specificity protein phosphatase 14 that is encoded in the genome of human.


name: MAP kinase tyrosine/serine/threonine phosphatase activity

description: Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate.


SPN1_HUMAN Snurportin-1 (sprot)

A snurportin-1 that is encoded in the genome of human.


RNA import into nucleus

description: The import of RNA from the cytoplasm to the nucleus.


snRNA import into nucleus

description: The directed movement of snRNA, small nuclear ribonucleic acid into the nucleus.


name: TNF15_HUMAN Tumor necrosis factor ligand superfamily member 15 (sprot)

description: A tumor necrosis factor ligand superfamily member 15 that is encoded in the genome of human.


name: RIMB1_HUMAN Peripheral-type benzodiazepine receptor-associated protein 1 (sprot)

description: A peripheral-type benzodiazepine receptor-associated protein 1 that is encoded in the genome of human.


benzodiazepine receptor binding

description: Binding to a peripheral benzodiazepine receptor (PBR).


name: ARK73_HUMAN Aflatoxin B1 aldehyde reductase member 3 (sprot)

description: An aflatoxin B1 aldehyde reductase member 3 that is encoded in the genome of human.


name: UBE4B_HUMAN Ubiquitin conjugation factor E4 B (sprot)

description: A ubiquitin conjugation factor E4 B that is encoded in the genome of human.


name: granzyme-mediated apoptotic signaling pathway

description: The series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.


NXPH2_HUMAN Neurexophilin-2 (sprot)

A neurexophilin-2 that is encoded in the genome of human.


NXPH3_HUMAN Neurexophilin-3 (sprot)

A neurexophilin-3 that is encoded in the genome of human.


NXPH4_HUMAN Neurexophilin-4 (sprot)

A neurexophilin-4 that is encoded in the genome of human.


name: ZFPL1_HUMAN Zinc finger protein-like 1 (sprot)

description: A zinc finger protein-like 1 that is encoded in the genome of human.


name: ELP1_HUMAN Elongator complex protein 1 (sprot)

description: An elongator complex protein 1 that is encoded in the genome of human.


tRNA wobble uridine modification

description: The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.


elongator holoenzyme complex

description: A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA.


name: UBL3_HUMAN Ubiquitin-like protein 3 (sprot)

description: A ubiquitin-like protein 3 that is encoded in the genome of human.


name: GBRAP_HUMAN Gamma-aminobutyric acid receptor-associated protein (sprot)

description: A gamma-aminobutyric acid receptor-associated protein that is encoded in the genome of human.


name: positive regulation of protein K48-linked ubiquitination

description: Any process that activates or increases the frequency, rate or extent of protein K48-linked ubiquitination.


name: NDUA3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 that is encoded in the genome of human.


name: NDUB4_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 that is encoded in the genome of human.


name: NDUB8_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial that is encoded in the genome of human.


name: CDRT1_HUMAN F-box and WD repeat domain containing protein 10B (sprot)

description: An F-box and WD repeat domain containing protein 10B that is encoded in the genome of human.


SCEL_HUMAN Sciellin (sprot)

A sciellin that is encoded in the genome of human.


name: GAAS1_HUMAN Uncharacterized protein GAS8-AS1 (sprot)


name: NDUB2_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial that is encoded in the genome of human.


name: CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H (sprot)

description: A voltage-dependent T-type calcium channel subunit alpha-1H that is encoded in the genome of human.


name: voltage-gated monoatomic ion channel activity

description: Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


aldosterone biosynthetic process

description: The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance.


cortisol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.


cellular response to potassium ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.


name: NDUA7_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 that is encoded in the genome of human.


name: VAMP5_HUMAN Vesicle-associated membrane protein 5 (sprot)

description: A vesicle-associated membrane protein 5 that is encoded in the genome of human.


name: UNC5C_HUMAN Netrin receptor UNC5C (sprot)

description: A netrin receptor UNC5C that is encoded in the genome of human.


name: netrin receptor activity involved in chemorepulsion

description: Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin.


anterior/posterior axon guidance

description: The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.


chemorepulsion of axon

description: The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.


dorsal root ganglion development

description: The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.


name: OAZ2_HUMAN Ornithine decarboxylase antizyme 2 (sprot)

description: An ornithine decarboxylase antizyme 2 that is encoded in the genome of human.


name: ornithine decarboxylase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of ornithine decarboxylase.


polyamine metabolic process

description: The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups.


polyamine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups.


name: negative regulation of polyamine transmembrane transport

description: Any process that stops, prevents or reduces the frequency, rate or extent of polyamine transmembrane transport.


name: CSPG5_HUMAN Chondroitin sulfate proteoglycan 5 (sprot)

description: A chondroitin sulfate proteoglycan 5 that is encoded in the genome of human.


glial cell projection elongation

description: The process of creating an elongation or projection from a glial cell.


RTN3_HUMAN Reticulon-3 (sprot)

A reticulon-3 that is encoded in the genome of human.


name: endoplasmic reticulum tubular network organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section.


name: endoplasmic reticulum tubular network formation

description: The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section.


name: KLHL2_HUMAN Kelch-like protein 2 (sprot)

description: A kelch-like protein 2 that is encoded in the genome of human.


name: RCBT2_HUMAN RCC1 and BTB domain-containing protein 2 (sprot)

description: An RCC1 and BTB domain-containing protein 2 that is encoded in the genome of human.


name: RHIT_HUMAN Transcriptional repressor RHIT (sprot)

description: A transcriptional repressor RHIT that is encoded in the genome of human.


name: positive regulation of hydrogen peroxide biosynthetic process

description: Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.


name: LETM1_HUMAN Mitochondrial proton/calcium exchanger protein (sprot)

description: A mitochondrial proton/calcium exchanger protein that is encoded in the genome of human.


name: calcium:proton antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in).


mitochondrial calcium ion homeostasis

description: Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.


name: negative regulation of mitochondrial calcium ion concentration

description: Any process that decreases the concentration of calcium ions in mitochondria.


calcium export from the mitochondrion

description: A process in which a calcium ion (Ca2+) is transported out of the mitochondrial matrix, and into the cytosol.


name: mitochondrial potassium ion transmembrane transport

description: The process in which a potassium ion is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: regulation of cellular hyperosmotic salinity response

description: Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response.


PCDH8_HUMAN Protocadherin-8 (sprot)

A protocadherin-8 that is encoded in the genome of human.


name: regulation of synaptic membrane adhesion

description: Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.


EPN2_HUMAN Epsin-2 (sprot)

An epsin-2 that is encoded in the genome of human.


name: negative regulation of sprouting angiogenesis

description: Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis.


name: STBD1_HUMAN Starch-binding domain-containing protein 1 (sprot)

description: A starch-binding domain-containing protein 1 that is encoded in the genome of human.


glycogen binding

description: Binding to glycogen.


starch binding

description: Binding to starch.


glycogen catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.


glycophagy

description: The selective degradation of glycogen by macroautophagy.


name: LERL1_HUMAN Leptin receptor overlapping transcript-like 1 (sprot)

description: A leptin receptor overlapping transcript-like 1 that is encoded in the genome of human.


name: ZRAB2_HUMAN Zinc finger Ran-binding domain-containing protein 2 (sprot)

description: A zinc finger Ran-binding domain-containing protein 2 that is encoded in the genome of human.


SNX4_HUMAN Sorting nexin-4 (sprot)

A sorting nexin-4 that is encoded in the genome of human.


name: positive regulation of histamine secretion by mast cell

description: Any process that activates or increases the frequency, rate or extent of histamine secretion by mast cell.


presynaptic endosome

description: An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles.


name: OR5F1_HUMAN Olfactory receptor 5F1 (sprot)

description: An olfactory receptor 5F1 that is encoded in the genome of human.


name: OR6A2_HUMAN Olfactory receptor 6A2 (sprot)

description: An olfactory receptor 6A2 that is encoded in the genome of human.


ZWINT_HUMAN ZW10 interactor (sprot)

A ZW10 interactor that is encoded in the genome of human.


name: homologous chromosome orientation in meiotic metaphase I

description: The cell cycle process in which the sister centromeres and kinetochores of one chromosome are fused and orientated so the chromosomes attach to microtubules that emanate from the same spindle pole. This process ensures that homologous l chromosomes are segregated at anaphase of meiosis I.


name: regulation of meiosis I spindle assembly checkpoint

description: Any process that modulates the frequency, rate or extent of the meiosis I spindle assembly checkpoint.


Knl1/Spc105 complex

description: A kinetochore subcomplex that binds to centromeric chromatin and forms part of the outer kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans and yeast respectively, it consists of KNL1/Spc105p and ZWINT/Kre28p.


name: VENTX_HUMAN Homeobox protein VENTX (sprot)

description: A homeobox protein VENTX that is encoded in the genome of human.


LC7L3_HUMAN Luc7-like protein 3 (sprot)

A cisplatin resistance-associated overexpressed protein that is encoded in the genome of human.


name: KI20A_HUMAN Kinesin-like protein KIF20A (sprot)

description: A kinesin-like protein KIF20A that is encoded in the genome of human.


APOL3_HUMAN Apolipoprotein L3 (sprot)

An apolipoprotein L3 that is encoded in the genome of human.


name: LRAT_HUMAN Lecithin retinol acyltransferase (sprot)

description: A lecithin retinol acyltransferase that is encoded in the genome of human.


O-palmitoyltransferase activity

description: Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule.


retinol binding

description: Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation.


description: Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine.


name: lecithin:11-cis retinol acyltransferase activity

description: Catalysis of the reaction: an 11-cis retinol-[cellular-retinol-binding-protein] + a phosphatidylcholine = a cellular-retinol-binding protein + an 11-cis-retinyl ester + a 1-lysophosphatidylcholine.


positive regulation of lipid transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: SPDEF_HUMAN SAM pointed domain-containing Ets transcription factor (sprot)

description: A SAM pointed domain-containing Ets transcription factor that is encoded in the genome of human.


glandular epithelial cell development

description: The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.


name: negative regulation of cell fate commitment

description: Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.


name: positive regulation of cell fate commitment

description: Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.


lung goblet cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a lung goblet cell. A goblet cell is a cell of the epithelial lining that produces and secretes mucins.


epithelial cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell.


name: KIF4A_HUMAN Chromosome-associated kinesin KIF4A (sprot)

description: A chromosome-associated kinesin KIF4A that is encoded in the genome of human.


name: MBD4_HUMAN Methyl-CpG-binding domain protein 4 (sprot)

description: A methyl-CpG-binding domain protein 4 that is encoded in the genome of human.


satellite DNA binding

description: Binding to satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA.


name: pyrimidine-specific mismatch base pair DNA N-glycosylase activity

description: Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.


DNA N-glycosylase activity

description: Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.


name: MTMR5_HUMAN Myotubularin-related protein 5 (sprot)

description: A myotubularin-related protein 5 that is encoded in the genome of human.


name: protein tyrosine/serine/threonine phosphatase activity

description: Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


name: GOSR1_HUMAN Golgi SNAP receptor complex member 1 (sprot)

description: A Golgi SNAP receptor complex member 1 that is encoded in the genome of human.


name: KAT7_HUMAN Histone acetyltransferase KAT7 (sprot)

description: A histone acetyltransferase KAT7 that is encoded in the genome of human.


name: histone H4K16 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4.


histone H4 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4.


name: histone H3K14 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14).


name: histone H3K23 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23).


histone H4K5 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5).


histone H4K8 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8).


histone H3K4 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4).


internal peptidyl-lysine acetylation

description: The addition of an acetyl group to a non-terminal lysine residue in a protein.


name: stress-activated protein kinase signaling cascade

description: The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal.


response to sorbitol

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus.


response to hydroxyurea

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.


response to actinomycin D

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus.


response to dithiothreitol

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus.


response to anisomycin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus.


name: DNA replication-dependent chromatin disassembly

description: The disruption of nucleosomes during DNA replication to allow the replication machinery to access the DNA.


name: histone H3-K14 acetyltransferase complex

description: A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3.


name: MRP6_HUMAN ATP-binding cassette sub-family C member 6 (sprot)

description: An ATP-binding cassette sub-family C member 6 that is encoded in the genome of human.


name: inhibition of non-skeletal tissue mineralization

description: A homeostatic process involved in the maintenance of non-mineral tissue, by preventing mineralization of non-skeletal tissue.


response to sodium phosphate

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus.


name: I18RA_HUMAN Interleukin-18 receptor accessory protein (sprot)

description: An interleukin-18 receptor accessory protein that is encoded in the genome of human.


NAD+ nucleosidase activity

description: Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose.


interleukin-18 receptor activity

description: Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


description: The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


interleukin-18 receptor complex

description: A protein complex that binds interleukin-18; comprises an alpha and a beta subunit.


name: GA45G_HUMAN Growth arrest and DNA damage-inducible protein GADD45 gamma (sprot)

description: A growth arrest and DNA damage-inducible protein GADD45 gamma that is encoded in the genome of human.


name: UCP5_HUMAN Brain mitochondrial carrier protein 1 (sprot)

description: A brain mitochondrial carrier protein 1 that is encoded in the genome of human.


name: solute:inorganic anion antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out).


name: proton transmembrane transporter activity

description: Enables the transfer of a proton from one side of a membrane to the other.


name: KCNH1_HUMAN Potassium voltage-gated channel subfamily H member 1 (sprot)

description: A voltage-gated potassium channel KCNH1 that is encoded in the genome of human.


cyclic nucleotide binding

description: Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.


name: delayed rectifier potassium channel activity

description: Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.


name: ATE1_HUMAN Arginyl-tRNA--protein transferase 1 (sprot)

description: An arginyl-tRNA--protein transferase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H+ + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg).


protein arginylation

description: The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway.


name: PDE8B_HUMAN High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (sprot)

description: A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B that is encoded in the genome of human.


operant conditioning

description: Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior.


name: negative regulation of steroid hormone biosynthetic process

description: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones.


name: 5HT3B_HUMAN 5-hydroxytryptamine receptor 3B (sprot)

description: A 5-hydroxytryptamine receptor 3B that is encoded in the genome of human.


name: GRP1_HUMAN RAS guanyl-releasing protein 1 (sprot)

description: A RAS guanyl-releasing protein 1 that is encoded in the genome of human.


name: positive regulation of granulocyte macrophage colony-stimulating factor production

description: Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


name: TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (sprot)

description: A poly [ADP-ribose] polymerase tankyrase-1 that is encoded in the genome of human.


NAD+ ADP-ribosyltransferase activity

description: Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.


description: Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide.


name: regulation of telomere maintenance via telomerase

description: Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase.


protein poly-ADP-ribosylation

description: The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain.


protein auto-ADP-ribosylation

description: The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.


name: negative regulation of telomere maintenance via telomere lengthening

description: Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening.


name: negative regulation of telomeric DNA binding

description: Any process that stops, prevents or reduces the frequency, rate or extent of telomeric DNA binding.


name: negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric

description: Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric.


name: CCDB1_HUMAN Cyclin-D1-binding protein 1 (sprot)

description: A cyclin-D1-binding protein 1 that is encoded in the genome of human.


name: LYPD3_HUMAN Ly6/PLAUR domain-containing protein 3 (sprot)

description: An Ly6/PLAUR domain-containing protein 3 that is encoded in the genome of human.


EPM2A_HUMAN Laforin (sprot)

A laforin (human), isoforms 1, 2, 4, 5, 6, 7, and 8.


glycogen (starch) synthase activity

description: Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1).


carbohydrate phosphatase activity

description: Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate.


glycogen metabolic process

description: The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.


name: regulation of protein import into nucleus

description: Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.


habituation

description: A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented.


name: cytoplasmic side of rough endoplasmic reticulum membrane

description: The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm.


name: KCNK5_HUMAN Potassium channel subfamily K member 5 (sprot)

description: A potassium channel subfamily K member 5 that is encoded in the genome of human.


name: potassium ion export across plasma membrane

description: The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region.


name: VAPB_HUMAN Vesicle-associated membrane protein-associated protein B/C (sprot)

description: A vesicle-associated membrane protein-associated protein B/C that is encoded in the genome of human.


FFAT motif binding

description: Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family.


COPII-coated vesicle budding

description: The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle.


name: RASL1_HUMAN RasGAP-activating-like protein 1 (sprot)

description: A RasGAP-activating-like protein 1 that is encoded in the genome of human.


name: SNAPN_HUMAN SNARE-associated protein Snapin (sprot)

description: A SNARE-associated protein Snapin that is encoded in the genome of human.


retrograde axonal transport

description: The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.


synaptic vesicle maturation

description: Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle.


name: synaptic vesicle fusion to presynaptic active zone membrane

description: Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.


regulation of protein binding

description: Any process that modulates the frequency, rate or extent of protein binding.


regulation of endosome size

description: Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis.


regulation of lysosome size

description: Any process that modulates the size of a lysosome.


name: positive regulation of late endosome to lysosome transport

description: Any process that activates or increases the frequency, rate or extent of late endosome to lysosome transport.


manchette

description: A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.


BLOC-1 complex

description: A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins.


cytoplasmic side of lysosomal membrane

description: The side (leaflet) of the lysosomal membrane that faces the cytoplasm.


BORC complex

description: A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors.


name: MPZL1_HUMAN Myelin protein zero-like protein 1 (sprot)

description: A myelin protein zero-like protein 1 that is encoded in the genome of human.


name: NDUC2_HUMAN NADH dehydrogenase [ubiquinone] 1 subunit C2 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 subunit C2 that is encoded in the genome of human.


name: NDUAA_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial that is encoded in the genome of human.


name: FKBP9_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP9 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP9 that is encoded in the genome of human.


name: CELF2_HUMAN CUGBP Elav-like family member 2 (sprot)

description: A CUGBP Elav-like family member 2 that is encoded in the genome of human.


A 6-phosphogluconolactonase that is encoded in the genome of human.


6-phosphogluconolactonase activity

description: Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+.


name: PAPS2_HUMAN Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (sprot)

description: A bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 that is encoded in the genome of human.


hormone metabolic process

description: The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.


name: ABCBB_HUMAN Bile salt export pump (sprot)

description: A bile salt export pump that is encoded in the genome of human.


name: bile acid transmembrane transporter activity

description: Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.


name: canalicular bile acid transmembrane transporter activity

description: The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.


name: carbohydrate transmembrane transporter activity

description: Enables the transfer of carbohydrate from one side of a membrane to the other.


regulation of fatty acid beta-oxidation

description: Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation.


carbohydrate transmembrane transport

description: The process in which a carbohydrate is transported across a membrane.


bile acid signaling pathway

description: The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


xenobiotic export from cell

description: The directed movement of a xenobiotic from a cell, into the extracellular region. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.


name: positive regulation of bile acid secretion

description: Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.


name: regulation of bile acid metabolic process

description: Any process that modulates the frequency, rate or extent of bile acid metabolic process.


intercellular canaliculus

description: An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates.


name: SIX3_HUMAN Homeobox protein SIX3 (sprot)

description: A homeobox protein SIX3 that is encoded in the genome of human.


epithelial cell maturation

description: The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.


optic vesicle morphogenesis

description: The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.


proximal/distal axis specification

description: The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).


neuroblast differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts.


telencephalon development

description: The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.


name: forebrain dorsal/ventral pattern formation

description: The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain.


telencephalon regionalization

description: The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops.


regulation of neural retina development

description: Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.


lens fiber cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities.


neuroblast migration

description: The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron.


name: regulation of cell cycle phase transition

description: Any process that modulates the frequency, rate or extent of cell cycle phase transition.


regulation of neuroblast proliferation

description: Any process that modulates the frequency, rate or extent of neuroblast proliferation.


lens fiber cell apoptotic process

description: Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.


name: SMC2_HUMAN Structural maintenance of chromosomes protein 2 (sprot)

description: A structural maintenance of chromosomes protein 2 that is encoded in the genome of human.


meiotic chromosome condensation

description: Compaction of chromatin structure prior to meiosis in eukaryotic cells.


meiotic chromosome segregation

description: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle.


name: positive regulation of chromosome segregation

description: Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.


name: positive regulation of chromosome condensation

description: Any process that activates or increases the frequency, rate or extent of chromosome condensation.


condensin complex

description: A multisubunit protein complex that plays a central role in chromosome condensation in meiosis and mitosis.


name: ATG7_HUMAN Ubiquitin-like modifier-activating enzyme ATG7 (sprot)

description: A ubiquitin-like modifier-activating enzyme ATG7 that is encoded in the genome of human.


Atg12 activating enzyme activity

description: Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond.


cellular response to hyperoxia

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.


name: TACC2_HUMAN Transforming acidic coiled-coil-containing protein 2 (sprot)

description: A transforming acidic coiled-coil-containing protein 2 that is encoded in the genome of human.


name: TRI16_HUMAN Tripartite motif-containing protein 16 (sprot)

description: A tripartite motif-containing protein 16 that is encoded in the genome of human.


NACHT domain binding

description: Binding to a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg2+-binding site and five more specific motifs.


response to organophosphorus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors.


name: positive regulation of retinoic acid receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity.


response to growth hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth.


name: SYFM_HUMAN Phenylalanine--tRNA ligase, mitochondrial (sprot)

description: A phenylalanine--tRNA ligase, mitochondrial that is encoded in the genome of human.


phenylalanine-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).


phenylalanyl-tRNA aminoacylation

description: The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


tRNA processing

description: The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.


name: ZBT7A_HUMAN Zinc finger and BTB domain-containing protein 7A (sprot)

description: A zinc finger and BTB domain-containing protein 7A that is encoded in the genome of human.


histone acetyltransferase binding

description: Binding to an histone acetyltransferase.


name: double-strand break repair via classical nonhomologous end joining

description: An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining).


name: regulation of transcription regulatory region DNA binding

description: Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding.


DNA-dependent protein kinase complex

description: A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku.


name: OR2C1_HUMAN Olfactory receptor 2C1 (sprot)

description: An olfactory receptor 2C1 that is encoded in the genome of human.


odorant binding

description: Binding to an odorant, any substance capable of stimulating the sense of smell.


name: LYPA2_HUMAN Acyl-protein thioesterase 2 (sprot)

description: An acyl-protein thioesterase 2 that is encoded in the genome of human.


acylglycerol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.


prostaglandin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of prostaglandin.


IPO7_HUMAN Importin-7 (sprot)

An importin-7 that is encoded in the genome of human.


name: positive regulation of odontoblast differentiation

description: Any process that activates or increases the frequency, rate or extent of odontoblast differentiation.


name: ARI2_HUMAN E3 ubiquitin-protein ligase ARIH2 (sprot)

description: An E3 ubiquitin-protein ligase ARIH2 that is encoded in the genome of human.


Cul5-RING ubiquitin ligase complex

description: A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.


developmental cell growth

description: The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.


name: CXB5_HUMAN Gap junction beta-5 protein (sprot)

description: A gap junction beta-5 protein that is encoded in the genome of human.


labyrinthine layer morphogenesis

description: The process in which the labyrinthine layer of the placenta is generated and organized.


epididymis development

description: The process whose specific outcome is the progression of an epididymis over time, from its formation to the mature structure.


name: TFIP8_HUMAN Tumor necrosis factor alpha-induced protein 8 (sprot)

description: A tumor necrosis factor alpha-induced protein 8 that is encoded in the genome of human.


name: M3K6_HUMAN Mitogen-activated protein kinase kinase kinase 6 (sprot)

description: A mitogen-activated protein kinase kinase kinase 6 that is encoded in the genome of human.


CCN4_HUMAN CCN family member 4 (sprot)

A CCN family member 4 that is encoded in the genome of human.


name: CCN6_HUMAN Cellular communication network factor 6 (sprot)

description: A cellular communication network factor 6 that is encoded in the genome of human.


name: regulation of reactive oxygen species biosynthetic process

description: Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process.


name: GDF11_HUMAN Growth/differentiation factor 11 (sprot)

description: A growth/differentiation factor 11 that is encoded in the genome of human.


name: spinal cord anterior/posterior patterning

description: The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord.


activin receptor signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


amacrine cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons.


type B pancreatic cell maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.


name: negative regulation of amacrine cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of amacrine cell differentiation.


name: SLU7_HUMAN Pre-mRNA-splicing factor SLU7 (sprot)

description: A pre-mRNA-splicing factor SLU7 that is encoded in the genome of human.


name: second spliceosomal transesterification activity

description: Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.


pre-mRNA 3'-splice site binding

description: Binding to a pre-mRNA 3' splice site sequence.


mRNA 3'-splice site recognition

description: Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome.


small nuclear ribonucleoprotein complex

description: A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs.


name: BMP10_HUMAN Bone morphogenetic protein 10 (sprot)

description: A bone morphogenetic protein 10 that is encoded in the genome of human.


telethonin binding

description: Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase.


name: receptor serine/threonine kinase binding

description: Binding to a receptor that possesses protein serine/threonine kinase activity.


name: atrial cardiac muscle tissue morphogenesis

description: The process in which the anatomical structure of cardiac atrium muscle is generated and organized.


cardiac muscle cell proliferation

description: The expansion of a cardiac muscle cell population by cell division.


name: positive regulation of cardiac muscle cell proliferation

description: Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.


name: positive regulation of sarcomere organization

description: Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


heart trabecula formation

description: The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.


name: positive regulation of cell proliferation involved in heart morphogenesis

description: Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis.


name: AGM1_HUMAN Phosphoacetylglucosamine mutase (sprot)

description: A phosphoacetylglucosamine mutase that is encoded in the genome of human.


description: Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.


glucosamine metabolic process

description: The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin.


name: GCNT3_HUMAN Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (sprot)

description: A beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 that is encoded in the genome of human.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.


description: Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP.


description: Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP.


tissue morphogenesis

description: The process in which the anatomical structures of a tissue are generated and organized.


intestinal absorption

description: A process in which nutrients are taken up from the contents of the intestine.


name: MOCS3_HUMAN Adenylyltransferase and sulfurtransferase MOCS3 (sprot)

description: An adenylyltransferase and sulfurtransferase MOCS3 that is encoded in the genome of human.


sulfurtransferase activity

description: Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).


URM1 activating enzyme activity

description: Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond.


description: Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine = AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase.


description: Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP.


name: Mo-molybdopterin cofactor biosynthetic process

description: The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.


tRNA thio-modification

description: The addition a sulfur atom to a nucleotide in a tRNA molecule.


name: molybdopterin cofactor metabolic process

description: The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.


name: PKHA9_HUMAN Putative protein PLEKHA9 (sprot)

description: A putative protein PLEKHA9 that is encoded in the genome of human.


name: RPGF3_HUMAN Rap guanine nucleotide exchange factor 3 (sprot)

description: A Rap guanine nucleotide exchange factor 3 that is encoded in the genome of human.


associative learning

description: Learning by associating a stimulus (the cause) with a particular outcome (the effect).


Rap protein signal transduction

description: An intracellular signaling cassette in which a small monomeric GTPase of the Rap subfamily relays a signal.


name: negative regulation of syncytium formation by plasma membrane fusion

description: Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.


name: positive regulation of protein export from nucleus

description: Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.


name: positive regulation of syncytium formation by plasma membrane fusion

description: Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.


UTS2_HUMAN Urotensin-2 (sprot)

A urotensin-2 that is encoded in the genome of human.


name: CD2B2_HUMAN CD2 antigen cytoplasmic tail-binding protein 2 (sprot)

description: A CD2 cytoplasmic tail-binding protein 2 that is encoded in the genome of human.


name: MED26_HUMAN Mediator of RNA polymerase II transcription subunit 26 (sprot)

description: A mediator of RNA polymerase II transcription subunit 26 that is encoded in the genome of human.


name: ZFYV9_HUMAN Zinc finger FYVE domain-containing protein 9 (sprot)

description: A zinc finger FYVE domain-containing protein 9 that is encoded in the genome of human.


1-phosphatidylinositol binding

description: Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.


name: CNIH1_HUMAN Protein cornichon homolog 1 (sprot)

description: A protein cornichon that is encoded in the genome of human.


name: TNF6B_HUMAN Tumor necrosis factor receptor superfamily member 6B (sprot)

description: A tumor necrosis factor receptor superfamily member 6B that is encoded in the genome of human.


name: ZIC2_HUMAN Zinc finger protein ZIC 2 (sprot)

description: A zinc finger protein ZIC 2 that is encoded in the genome of human.


name: TIAF1_HUMAN Putative TGFB1-induced anti-apoptotic factor 1 (sprot)

description: A TGFB1-induced anti-apoptotic factor 1 that is encoded in the genome of human.


name: BRI3_HUMAN Membrane protein BRI3 (sprot)

description: A membrane protein BRI3 that is encoded in the genome of human.


name: SOX14_HUMAN Transcription factor SOX-14 (sprot)

description: A transcription factor SOX-14 that is encoded in the genome of human.


name: DEXI_HUMAN Dexamethasone-induced protein (sprot)

description: A dexamethasone-induced protein that is encoded in the genome of human.


SVIL_HUMAN Supervillin (sprot)

A supervillin that is encoded in the genome of human.


microtubule minus-end

description: The end of a microtubule that does not preferentially grow (polymerize).


name: PIGN_HUMAN GPI ethanolamine phosphate transferase 1 (sprot)

description: A GPI ethanolamine phosphate transferase 1 that is encoded in the genome of human.


description: Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor.


name: preassembly of GPI anchor in ER membrane

description: The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane.


PPN_HUMAN Papilin (sprot)

A papilin that is encoded in the genome of human.


name: BAG4_HUMAN BAG family molecular chaperone regulator 4 (sprot)

description: A BAG family molecular chaperone regulator 4 that is encoded in the genome of human.


name: positive regulation of fibroblast migration

description: Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.


name: negative regulation of mRNA modification

description: Any process that decreases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.


name: negative regulation of protein targeting to mitochondrion

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to mitochondrion.


name: AHSA1_HUMAN Activator of 90 kDa heat shock protein ATPase homolog 1 (sprot)

description: An activator of 90 kDa heat shock protein ATPase homolog 1 that is encoded in the genome of human.


name: NPT2B_HUMAN Sodium-dependent phosphate transport protein 2B (sprot)

description: A sodium-dependent phosphate transport protein 2B that is encoded in the genome of human.


protein metabolic process

description: The chemical reactions and pathways involving a protein. Includes protein modification.


APOM_HUMAN Apolipoprotein M (sprot)

An apolipoprotein M that is encoded in the genome of human.


antioxidant activity

description: Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.


name: high-density lipoprotein particle remodeling

description: The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL.


name: high-density lipoprotein particle assembly

description: The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.


name: high-density lipoprotein particle clearance

description: The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


name: negative regulation of plasma lipoprotein oxidation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein particle oxidation, occurring in the blood plasma.


reverse cholesterol transport

description: The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism.


low-density lipoprotein particle

description: A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver.


name: discoidal high-density lipoprotein particle

description: A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase).


name: spherical high-density lipoprotein particle

description: A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT).


name: LCA5L_HUMAN Lebercilin-like protein (sprot)

description: A lebercilin-like protein that is encoded in the genome of human.


name: ATS2_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 2 (sprot)

description: An a disintegrin and metalloproteinase with thrombospondin motifs 2 that is encoded in the genome of human.


name: CXB6_HUMAN Gap junction beta-6 protein (sprot)

description: A gap junction beta-6 protein that is encoded in the genome of human.


name: gap junction channel activity involved in cell communication by electrical coupling

description: Any gap junction channel activity that is involved in cell communication by electrical coupling.


name: cell communication by electrical coupling

description: The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.


gap junction assembly

description: Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids.


name: gap junction-mediated intercellular transport

description: The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells.


name: PARN_HUMAN Poly(A)-specific ribonuclease PARN (sprot)

description: A poly(A)-specific ribonuclease PARN that is encoded in the genome of human.


cation binding

description: Binding to a cation, a charged atom or group of atoms with a net positive charge.


box H/ACA sno(s)RNA 3'-end processing

description: Any process involved in forming the mature 3' end of a box H/ACA RNA molecule.


RNA modification

description: The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.


miRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.


name: poly(A)-dependent snoRNA 3'-end processing

description: Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA.


name: TGDS_HUMAN dTDP-D-glucose 4,6-dehydratase (sprot)

description: A dTDP-D-glucose 4,6-dehydratase that is encoded in the genome of human.


nucleotide-sugar metabolic process

description: The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.


name: PSMG1_HUMAN Proteasome assembly chaperone 1 (sprot)

description: A proteasome assembly chaperone 1 that is encoded in the genome of human.


name: cerebellar granule cell precursor proliferation

description: The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.


MATN4_HUMAN Matrilin-4 (sprot)

A matrilin-4 that is encoded in the genome of human.


name: LARG1_HUMAN Xylosyl- and glucuronyltransferase LARGE1 (sprot)

description: A xylosyl- and glucuronyltransferase LARGE1 that is encoded in the genome of human.


xylosyltransferase activity

description: Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


glycoprotein biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.


dentate gyrus development

description: The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus.


post-embryonic hindlimb morphogenesis

description: The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized.


name: neuromuscular process controlling posture

description: Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts.


localization of cell

description: Any process in which a cell is transported to, and/or maintained in, a specific location.


striated muscle cell development

description: The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.


name: retina vasculature development in camera-type eye

description: The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.


connective tissue development

description: The progression of a connective tissue over time, from its formation to the mature structure.


walking behavior

description: The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg.


name: acetylcholine receptor signaling pathway

description: The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands.


skeletal muscle fiber differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract.


reactive gliosis

description: A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells.


name: FMNL1_HUMAN Formin-like protein 1 (sprot)

description: A formin-like protein 1 that is encoded in the genome of human.


bleb

description: A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.


name: GNAS3_HUMAN Neuroendocrine secretory protein 55 (sprot)


response to parathyroid hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus.


name: SGPL1_HUMAN Sphingosine-1-phosphate lyase 1 (sprot)

description: A sphingosine-1-phosphate lyase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.


luteinization

description: The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.


CLD7_HUMAN Claudin-7 (sprot)

A claudin-7 that is encoded in the genome of human.


name: SIX6_HUMAN Homeobox protein SIX6 (sprot)

description: A homeobox protein SIX6 that is encoded in the genome of human.


name: CNEP1_HUMAN CTD nuclear envelope phosphatase 1 (sprot)

description: A serine/threonine-protein phosphatase dullard that is encoded in the genome of human.


mitotic nuclear membrane disassembly

description: The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis.


gamete generation

description: The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.


name: positive regulation of triglyceride biosynthetic process

description: Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.


Nem1-Spo7 phosphatase complex

description: A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p.


name: ABCA1_HUMAN Phospholipid-transporting ATPase ABCA1 (sprot)

description: A phospholipid-transporting ATPase ABCA1 that is encoded in the genome of human.


phospholipid transporter activity

description: Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.


name: high-density lipoprotein particle binding

description: Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE.


apolipoprotein A-I binding

description: Binding to apolipoprotein A-I.