name: 3BHS2_HUMAN 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (sprot)

description: A 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 that is encoded in the genome of human.


name: IVD_HUMAN Isovaleryl-CoA dehydrogenase, mitochondrial (sprot)

description: An isovaleryl-CoA dehydrogenase, mitochondrial that is encoded in the genome of human.


isovaleryl-CoA dehydrogenase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein].


L-leucine catabolic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways resulting in the breakdown of L-leucine, 2-amino-4-methylpentanoic acid.


name: CNTF_HUMAN Ciliary neurotrophic factor (sprot)

description: A ciliary neurotrophic factor that is encoded in the genome of human.


name: negative regulation of photoreceptor cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.


S10A4_HUMAN Protein S100-A4 (sprot)

A protein S100-A4 that is encoded in the genome of human.


name: MGAT1_HUMAN Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (sprot)

description: An alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase that is encoded in the genome of human.


description: Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H+ + UDP.


description: The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


name: HMGB2_HUMAN High mobility group protein B2 (sprot)

description: A high mobility group protein B2 that is encoded in the genome of human.


name: non-sequence-specific DNA binding, bending

description: The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.


regulation of stem cell proliferation

description: Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.


name: PTBP1_HUMAN Polypyrimidine tract-binding protein 1 (sprot)

description: A polypyrimidine tract-binding protein 1 that is encoded in the genome of human.


poly-pyrimidine tract binding

description: Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule.


name: SYTC_HUMAN Threonine--tRNA ligase 1, cytoplasmic (sprot)

description: A threonine--tRNA ligase 1, cytoplasmic that is encoded in the genome of human.


SYVC_HUMAN Valine--tRNA ligase (sprot)

A valine--tRNA ligase that is encoded in the genome of human.


valine-tRNA ligase activity

description: Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H+.


name: EF1G_HUMAN Elongation factor 1-gamma (sprot)

description: An elongation factor 1-gamma that is encoded in the genome of human.


name: TTP_HUMAN mRNA decay activator protein ZFP36 (sprot)

description: An mRNA decay activator protein ZFP36 that is encoded in the genome of human.


C-C chemokine binding

description: Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.


name: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

description: A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.


name: regulation of keratinocyte proliferation

description: Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.


name: nuclear-transcribed mRNA catabolic process, deadenylation-independent decay

description: A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability.


name: positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA

description: Any process that activates or increases the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA.


name: negative regulation of hematopoietic stem cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation.


name: regulation of keratinocyte apoptotic process

description: Any process that modulates the frequency, rate or extent of keratinocyte apoptotic process.


name: negative regulation of polynucleotide adenylyltransferase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of polynucleotide adenylyltransferase activity.


name: positive regulation of intracellular mRNA localization

description: Any process that activates or increases the frequency, rate or extent of intracellular mRNA localization.


name: positive regulation of miRNA-mediated gene silencing

description: A process that activates or increases the frequency, rate or extent of gene silencing by a microRNA (miRNA).


name: PPLA_HUMAN Cardiac phospholamban (sprot)

description: A cardiac phospholamban that is encoded in the genome of human.


ATPase inhibitor activity

description: Binds to and stops, prevents or reduces an ATP hydrolysis activity.


name: regulation of cardiac muscle cell contraction

description: Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction.


name: adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals beginning with a G protein-coupled adrenergic cell surface receptor combining with epinephrine or norepinephrine, to activate adenylate cyclase, which contributes to a circulatory system process carried out by the heart.


name: regulation of relaxation of cardiac muscle

description: Any process that modulates the frequency, rate or extent of relaxation of cardiac muscle.


calcium ion-transporting ATPase complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in).


name: NKG2A_HUMAN NKG2-A/NKG2-B type II integral membrane protein (sprot)

description: An NKG2-A/NKG2-B type II integral membrane protein that is encoded in the genome of human.


name: inhibitory MHC class Ib receptor activity

description: Combining with a MHC class Ib protein complex to mediate signaling that inhibits activation of a lymphocyte.


name: HLA-E specific inhibitory MHC class Ib receptor activity

description: Combining with a MHC class Ib molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte.


name: CD8-positive, gamma-delta intraepithelial T cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.


name: natural killer cell inhibitory signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response.


name: regulation of natural killer cell activation

description: Any process that modulates the frequency, rate or extent of natural killer cell activation.


name: NKG2C_HUMAN NKG2-C type II integral membrane protein (sprot)

description: An NKG2-C type II integral membrane protein that is encoded in the genome of human.


name: activating MHC class Ib receptor activity

description: Combining with a MHC class Ib protein complex to mediate signaling that activates a lymphocyte.


natural killer cell mediated immunity

description: The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines.


name: NKG2D_HUMAN NKG2-D type II integral membrane protein (sprot)

description: An NKG2-D type II integral membrane protein that is encoded in the genome of human.


CD27_HUMAN CD27 antigen (sprot)

A CD27 molecule that is encoded in the genome of human.


CD27 signaling pathway

description: The series of molecular signals initiated by the binding of the cell surface receptor CD27 to its physiological ligand CD70, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: FKBP2_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP2 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP2 that is encoded in the genome of human.


name: HGFL_HUMAN Hepatocyte growth factor-like protein (sprot)

description: A hepatocyte growth factor-like protein that is encoded in the genome of human.


name: regulation of cAMP-dependent protein kinase activity

description: Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity.


name: IL3RA_HUMAN Interleukin-3 receptor subunit alpha (sprot)

description: An interleukin-3 receptor class 2 alpha chain that is encoded in the genome of human.


interleukin-3 receptor activity

description: Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha (sprot)

description: A ciliary neurotrophic factor receptor subunit alpha that is encoded in the genome of human.


CNTFR-CLCF1 complex

description: A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space.


CRBB3_HUMAN Beta-crystallin B3 (sprot)

A beta-crystallin B3 that is encoded in the genome of human.


name: AVR2A_HUMAN Activin receptor type-2A (sprot)

description: An activin receptor type-2A that is encoded in the genome of human.


activin receptor activity

description: Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta.


name: positive regulation of activin receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway.


STOM_HUMAN Stomatin (sprot)

A stomatin that is encoded in the genome of human.


name: KAD4_HUMAN Adenylate kinase 4, mitochondrial (sprot)

description: An adenylate kinase 4, mitochondrial that is encoded in the genome of human.


name: nucleoside monophosphate kinase activity

description: Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate.


name: ribonucleoside diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar.


name: PON1_HUMAN Serum paraoxonase/arylesterase 1 (sprot)

description: A serum paraoxonase/arylesterase 1 that is encoded in the genome of human.


aryldialkylphosphatase activity

description: Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.


description: Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone = H+ + an N-acyl-L-homoserine.


carboxylic acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.


organophosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound.


lactone catabolic process

description: The chemical reactions and pathways resulting in the breakdown of lactone.


ANX13_HUMAN Annexin A13 (sprot)

An annexin A13 that is encoded in the genome of human.


phosphatidylglycerol binding

description: Binding to phosphatidylglycerol.


name: AOFB_HUMAN Amine oxidase [flavin-containing] B (sprot)

description: An amine oxidase [flavin-containing] B that is encoded in the genome of human.


phenylethylamine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds.


name: 1433T_HUMAN 14-3-3 protein theta (sprot)

description: A 14-3-3 protein theta that is encoded in the genome of human.


name: negative regulation of monoatomic ion transmembrane transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.


name: IF_HUMAN Cobalamin binding intrinsic factor (sprot)

description: A cobalamin binding intrinsic factor that is encoded in the genome of human.


name: MK03_HUMAN Mitogen-activated protein kinase 3 (sprot)

description: A mitogen-activated protein kinase 3 that is encoded in the genome of human.


regulation of cellular pH

description: Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment.


positive regulation of cyclase activity

description: Any process that activates or increases the activity of a cyclase.


name: cardiac neural crest cell development involved in heart development

description: The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart.


caveolin-mediated endocytosis

description: An endocytosis process that begins when material is taken up into plasma membrane caveolae, which then pinch off to form endocytic caveolar carriers.


regulation of Golgi inheritance

description: Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division.


name: MARK3_HUMAN MAP/microtubule affinity-regulating kinase 3 (sprot)

description: A MAP/microtubule affinity-regulating kinase 3 that is encoded in the genome of human.


name: VATL_HUMAN V-type proton ATPase 16 kDa proteolipid subunit c (sprot)

description: A V-type proton ATPase 16 kDa proteolipid subunit c that is encoded in the genome of human.


name: G0S2_HUMAN G0/G1 switch protein 2 (sprot)

description: A G0/G1 switch protein 2 that is encoded in the genome of human.


name: CALL3_HUMAN Calmodulin-like protein 3 (sprot)

description: A calmodulin-like protein 3 that is encoded in the genome of human.


name: DPP4_HUMAN Dipeptidyl peptidase 4 (sprot)

description: A dipeptidyl peptidase 4 that is encoded in the genome of human.


dipeptidyl-peptidase activity

description: Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain.


glucagon processing

description: The formation of mature glucagon by proteolysis of the precursor proglucagon.


name: GDF1_HUMAN Embryonic growth/differentiation factor 1 (sprot)

description: An embryonic growth/differentiation factor 1 that is encoded in the genome of human.


name: ARNT_HUMAN Aryl hydrocarbon receptor nuclear translocator (sprot)

description: An aryl hydrocarbon receptor nuclear translocator that is encoded in the genome of human.


name: nuclear aryl hydrocarbon receptor complex

description: An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT).


CERS1_HUMAN Ceramide synthase 1 (sprot)

A ceramide synthase 1 that is encoded in the genome of human.


sphingosine N-acyltransferase activity

description: Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine.


cellular response to mycotoxin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi.


cellular response to dithiothreitol

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus.


name: RL10_HUMAN Large ribosomal subunit protein uL16 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL16 that is encoded in the genome of human.


name: CO8A1_HUMAN Collagen alpha-1(VIII) chain (sprot)

description: A collagen alpha-1(VIII) chain that is encoded in the genome of human.


collagen type VIII trimer

description: A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets.


name: RFA1_HUMAN Replication protein A 70 kDa DNA-binding subunit (sprot)

description: A replication protein A 70 kDa DNA-binding subunit that is encoded in the genome of human.


name: APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (sprot)

description: A DNA-(apurinic or apyrimidinic site) endonuclease that is encoded in the genome of human.


3'-5'-DNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule.


name: double-stranded DNA exodeoxyribonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule.


name: site-specific endodeoxyribonuclease activity, specific for altered base

description: Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks.


name: class II DNA-(apurinic or apyrimidinic site) endonuclease activity

description: Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.


name: phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands

description: Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand.


DNA-(abasic site) binding

description: Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base.


name: telomere maintenance via base-excision repair

description: A telomere maintenance process that occurs by base-excision repair of telomeric DNA in response to DNA damage. Telomeric sequences are particularly susceptible to oxidative DNA damage, due to their G-rich nature.


CD82_HUMAN CD82 antigen (sprot)

A CD82 molecule that is encoded in the genome of human.


DCK_HUMAN Deoxycytidine kinase (sprot)

A deoxycytidine kinase that is encoded in the genome of human.


deoxyadenosine kinase activity

description: Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H+.


deoxyguanosine kinase activity

description: Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H+.


cytidine kinase activity

description: Catalysis of the reaction: ATP + cytidine = ADP + CMP.


CMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate.


dAMP salvage

description: Any process which produces a dAMP from derivatives of it, without de novo synthesis.


name: nucleoside phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a nucleoside phosphate.


name: PYR1_HUMAN Multifunctional protein CAD (sprot)

description: A multifunctional protein CAD that is encoded in the genome of human.


aspartate carbamoyltransferase activity

description: Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate.


name: carbamoyl-phosphate synthase (ammonia) activity

description: Catalysis of the reaction: 2 ATP + hydrogencarbonate + NH4+ = 2 ADP + carbamoyl phosphate + 2 H+ + phosphate.


name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

description: Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.


dihydroorotase activity

description: Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+.


aspartate binding

description: Binding to aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4.


CALR_HUMAN Calreticulin (sprot)

A calreticulin that is encoded in the genome of human.


name: negative regulation of intracellular steroid hormone receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.


name: PDE4A_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4A (sprot)

description: A 3',5'-cyclic-AMP phosphodiesterase 4A that is encoded in the genome of human.


name: regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway.


name: MAP4_HUMAN Microtubule-associated protein 4 (sprot)

description: A microtubule-associated protein 4 that is encoded in the genome of human.


microtubule sliding

description: The movement of one microtubule along another microtubule.


establishment of spindle orientation

description: Any process that set the alignment of spindle relative to other cellular structures.


microtubule stabilizing activity

description: A protein-containing complex stabilizing activity that prevents dissociation of microtubules.


CALX_HUMAN Calnexin (sprot)

A calnexin that is encoded in the genome of human.


PROP_HUMAN Properdin (sprot)

A properdin that is encoded in the genome of human.


cytoplasmic side of Golgi membrane

description: The side (leaflet) of the Golgi membrane that faces the cytoplasm.


name: IL1R2_HUMAN Interleukin-1 receptor type 2 (sprot)

description: An interleukin-1 receptor type 2 that is encoded in the genome of human.


name: interleukin-1, type II, blocking receptor activity

description: Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors.


name: negative regulation of interleukin-1 alpha production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production.


name: P85A_HUMAN Phosphatidylinositol 3-kinase regulatory subunit alpha (sprot)

description: A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of human.


name: phosphatidylinositol 3-kinase regulator activity

description: Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.


name: perinuclear endoplasmic reticulum membrane

description: The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus.


name: IP3KB_HUMAN Inositol-trisphosphate 3-kinase B (sprot)

description: An inositol-trisphosphate 3-kinase B that is encoded in the genome of human.


name: inositol trisphosphate metabolic process

description: The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.


name: negative regulation of neutrophil apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process.


name: AOAH_HUMAN Acyloxyacyl hydrolase (sprot)

description: An acyloxyacyl hydrolase that is encoded in the genome of human.


acyloxyacyl hydrolase activity

description: Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid.


lipopolysaccharide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.


name: PSB8_HUMAN Proteasome subunit beta type-8 (sprot)

description: A proteasome subunit beta type-8 that is encoded in the genome of human.


spermatoproteasome complex

description: A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity.


name: PSB9_HUMAN Proteasome subunit beta type-9 (sprot)

description: A proteasome subunit beta type-9 that is encoded in the genome of human.


name: regulation of cysteine-type endopeptidase activity

description: Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity.


name: PSA5_HUMAN Proteasome subunit alpha type-5 (sprot)

description: A proteasome subunit alpha type-5 that is encoded in the genome of human.


name: DMA_HUMAN HLA class II histocompatibility antigen, DM alpha chain (sprot)

description: An MHC class II histocompatibility antigen, DM alpha chain that is encoded in the genome of human.


name: DMB_HUMAN HLA class II histocompatibility antigen, DM beta chain (sprot)

description: An MHC class II histocompatibility antigen, DM beta chain that is encoded in the genome of human.


MHC class II protein complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex.


name: PIT1_HUMAN Pituitary-specific positive transcription factor 1 (sprot)

description: A pituitary-specific positive transcription factor 1 that is encoded in the genome of human.


name: PSB4_HUMAN Proteasome subunit beta type-4 (sprot)

description: A proteasome subunit beta type-4 that is encoded in the genome of human.


name: PSB6_HUMAN Proteasome subunit beta type-6 (sprot)

description: A proteasome subunit beta type-6 that is encoded in the genome of human.


name: PSB5_HUMAN Proteasome subunit beta type-5 (sprot)

description: A proteasome subunit beta type-5 that is encoded in the genome of human.


name: GSTM2_HUMAN Glutathione S-transferase Mu 2 (sprot)

description: A glutathione S-transferase mu 2 that is encoded in the genome of human.


name: 5HT1D_HUMAN 5-hydroxytryptamine receptor 1D (sprot)

description: A 5-hydroxytryptamine receptor 1D that is encoded in the genome of human.


name: 5HT1B_HUMAN 5-hydroxytryptamine receptor 1B (sprot)

description: A 5-hydroxytryptamine receptor 1B that is encoded in the genome of human.


serotonin binding

description: Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.


name: negative regulation of gamma-aminobutyric acid secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid.


name: negative regulation of synaptic transmission, GABAergic

description: Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).


serotonergic synapse

description: A synapse that uses serotonin as a neurotransmitter.


name: G protein-coupled serotonin receptor complex

description: A protein complex that is capable of G protein-coupled serotonin receptor activity.


name: 5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (sprot)

description: A 5-hydroxytryptamine receptor 2A that is encoded in the genome of human.


name: Gq/11-coupled serotonin receptor activity

description: Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels.


description: Binding to the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug.


name: positive regulation of phosphatidylinositol biosynthetic process

description: Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol.


positive regulation of heat generation

description: Any process that activates or increases the rate or extent of heat generation.


protein localization to cytoskeleton

description: A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.


name: ABCD3_HUMAN ATP-binding cassette sub-family D member 3 (sprot)

description: An ATP-binding cassette sub-family D member 3 that is encoded in the genome of human.


name: long-chain fatty acid import into peroxisome

description: The directed movement of a long-chain fatty acid into a peroxisome. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


phytanic acid metabolic process

description: The chemical reactions and pathways involving phytanic acid.


TMOD1_HUMAN Tropomodulin-1 (sprot)

A tropomodulin-1 that is encoded in the genome of human.


pointed-end actin filament capping

description: The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.


striated muscle thin filament

description: Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.


ITPI2_HUMAN Protein ITPRID2 (sprot)

A protein ITPRID2 that is encoded in the genome of human.


name: LYOX_HUMAN Protein-lysine 6-oxidase (sprot)

description: A protein-lysine 6-oxidase that is encoded in the genome of human.


protein-lysine 6-oxidase activity

description: Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide.


peptidyl-lysine oxidation

description: The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens.


ascending aorta development

description: The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.


descending aorta development

description: The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.


name: regulation of platelet-derived growth factor receptor-beta signaling pathway

description: Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway.


name: ELK4_HUMAN ETS domain-containing protein Elk-4 (sprot)

description: An ETS domain-containing protein Elk-4 that is encoded in the genome of human.


CYTD_HUMAN Cystatin-D (sprot)

A cystatin-D that is encoded in the genome of human.


name: PEX2_HUMAN Peroxisome biogenesis factor 2 (sprot)

description: A peroxisome assembly factor 1 that is encoded in the genome of human.


pexophagy

description: The selective autophagy process in which a peroxisome is degraded by macroautophagy.


response to amino acid starvation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.


Cdc73/Paf1 complex

description: A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p.


name: CLAT_HUMAN Choline O-acetyltransferase (sprot)

description: A choline O-acetyltransferase that is encoded in the genome of human.


choline O-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA.


name: ACADL_HUMAN Long-chain specific acyl-CoA dehydrogenase, mitochondrial (sprot)

description: A long-chain specific acyl-CoA dehydrogenase, mitochondrial that is encoded in the genome of human.


name: long-chain fatty acyl-CoA dehydrogenase activity

description: Catalysis of the reaction: a long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


carnitine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.


cellular lipid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.


name: negative regulation of fatty acid oxidation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation.


name: NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (sprot)

description: An NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial that is encoded in the genome of human.


name: ADH6_HUMAN Alcohol dehydrogenase 6 (sprot)

description: An alcohol dehydrogenase 6 that is encoded in the genome of human.


name: 5HT2C_HUMAN 5-hydroxytryptamine receptor 2C (sprot)

description: A 5-hydroxytryptamine receptor 2C that is encoded in the genome of human.


name: phospholipase C-activating serotonin receptor signaling pathway

description: A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: regulation of corticotropin-releasing hormone secretion

description: Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion.


name: NMBR_HUMAN Neuromedin-B receptor (sprot)

description: A neuromedin-B receptor that is encoded in the genome of human.


bombesin receptor activity

description: Combining with bombesin to initiate a change in cell activity.


bombesin receptor signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by a bombesin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: DPOD1_HUMAN DNA polymerase delta catalytic subunit (sprot)

description: A DNA polymerase delta catalytic subunit that is encoded in the genome of human.


error-free translesion synthesis

description: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.


delta DNA polymerase complex

description: A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair.


name: TEAD1_HUMAN Transcriptional enhancer factor TEF-1 (sprot)

description: A transcriptional enhancer factor TEF-1 that is encoded in the genome of human.


TEAD-YAP complex

description: A transcription factor complex that is composed of the one DNA binding protein of the TEAD family and the transcriptional coactivator YAP.


name: HXD9_HUMAN Homeobox protein Hox-D9 (sprot)

description: A homeobox protein Hox-D9 that is encoded in the genome of human.


hindlimb morphogenesis

description: The process in which the anatomical structures of the hindlimb are generated and organized.


name: HXD10_HUMAN Homeobox protein Hox-D10 (sprot)

description: A homeobox protein Hox-D10 that is encoded in the genome of human.


name: spinal cord motor neuron cell fate specification

description: The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.


name: MSX1_HUMAN Homeobox protein MSX-1 (sprot)

description: A homeobox protein MSX-1 that is encoded in the genome of human.


regulation of odontogenesis

description: Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth.


name: negative regulation of striated muscle cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation.


name: cell surface receptor signaling pathway involved in heart development

description: The series of molecular signals initiated by a ligand the binding to its receptor on the surface of a cell, which contributes to the progression of the heart over time.


name: negative regulation of odontoblast differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of odontoblast differentiation.


name: positive regulation of mesenchymal cell apoptotic process

description: Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process.


name: SMCA1_HUMAN Probable global transcription activator SNF2L1 (sprot)

description: A probable global transcription activator SNF2L1 that is encoded in the genome of human.


CERF complex

description: An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2L in mammals, which contain two ISWI homologs) and a CECR2 homolog. In mammals, CERF is involved in regulation of transcription from RNA polymerase II promoters.


name: GBRB3_HUMAN Gamma-aminobutyric acid receptor subunit beta-3 (sprot)

description: A gamma-aminobutyric acid receptor subunit beta-3 that is encoded in the genome of human.


name: GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2 (sprot)

description: A gamma-aminobutyric acid receptor subunit rho-2 that is encoded in the genome of human.


name: MK01_HUMAN Mitogen-activated protein kinase 1 (sprot)

description: A mitogen-activated protein kinase 1 that is encoded in the genome of human.


cytosine metabolic process

description: The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives.


ERBB signaling pathway

description: The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: DUS1_HUMAN Dual specificity protein phosphatase 1 (sprot)

description: A dual specificity protein phosphatase 1 that is encoded in the genome of human.


peptidyl-serine dephosphorylation

description: The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine.


name: 5HT1E_HUMAN 5-hydroxytryptamine receptor 1E (sprot)

description: A 5-hydroxytryptamine receptor 1E that is encoded in the genome of human.


GRAN_HUMAN Grancalcin (sprot)

A grancalcin that is encoded in the genome of human.


name: MZF1_HUMAN Myeloid zinc finger 1 (sprot)

description: A myeloid zinc finger 1 that is encoded in the genome of human.


name: RXRB_HUMAN Retinoic acid receptor RXR-beta (sprot)

description: A retinoic acid receptor RXR-beta that is encoded in the genome of human.


name: ERCC5_HUMAN DNA excision repair protein ERCC-5 (sprot)

description: A DNA excision repair protein ERCC-5 that is encoded in the genome of human.


base-excision repair, AP site formation

description: The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired.


name: RBL1_HUMAN Retinoblastoma-like protein 1 (sprot)

description: A retinoblastoma-like protein 1 that is encoded in the genome of human.


GRN_HUMAN Progranulin (sprot)

A progranulin that is encoded in the genome of human.


name: negative regulation of neutrophil activation

description: Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil activation.


positive regulation of protein folding

description: Any process that activates or increases the frequency, rate or extent of protein folding.


name: positive regulation of aspartic-type peptidase activity

description: Any process that activates or increases the frequency, rate or extent of aspartic-type peptidase activity.


name: PTPRM_HUMAN Receptor-type tyrosine-protein phosphatase mu (sprot)

description: A receptor-type tyrosine-protein phosphatase mu that is encoded in the genome of human.


name: AMPL_HUMAN Cytosol aminopeptidase (sprot)

description: A cytosol aminopeptidase that is encoded in the genome of human.


name: DHI1_HUMAN 11-beta-hydroxysteroid dehydrogenase 1 (sprot)

description: An 11-beta-hydroxysteroid dehydrogenase 1 that is encoded in the genome of human.


name: 7-beta-hydroxysteroid dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid.


name: 11-beta-hydroxysteroid dehydrogenase (NADP+) activity

description: Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+.


cortisol dehydrogenase activity

description: Catalysis of the reaction: cortisol + NADP = cortisone + NADPH + H+.


name: CD34_HUMAN Hematopoietic progenitor cell antigen CD34 (sprot)

description: A CD34 molecule that is encoded in the genome of human.


transdifferentiation

description: The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.


name: positive regulation of granulocyte colony-stimulating factor production

description: Any process that activates or increases the frequency, rate, or extent of production of granulocyte colony-stimulating factor.


extracellular exosome assembly

description: The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm.


name: metanephric glomerular mesangial cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the metanephros as it progresses from its formation to the mature state.


glomerular endothelium fenestra

description: A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes.


name: CD38_HUMAN ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (sprot)

description: An ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 that is encoded in the genome of human.


name: TNR8_HUMAN Tumor necrosis factor receptor superfamily member 8 (sprot)

description: A tumor necrosis factor receptor superfamily member 8 that is encoded in the genome of human.


name: CD1B_HUMAN T-cell surface glycoprotein CD1b (sprot)

description: A T-cell surface glycoprotein CD1b that is encoded in the genome of human.


name: CD1C_HUMAN T-cell surface glycoprotein CD1c (sprot)

description: A T-cell surface glycoprotein CD1c that is encoded in the genome of human.


endogenous lipid antigen binding

description: Binding to an endogenous cellular lipid antigen.


glycolipid binding

description: Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate.


name: CXB2_HUMAN Gap junction beta-2 protein (sprot)

description: A gap junction beta-2 protein that is encoded in the genome of human.


name: response to human chorionic gonadotropin

description: Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus.


S10A2_HUMAN Protein S100-A2 (sprot)

A protein S100-A2 that is encoded in the genome of human.


name: PTN4_HUMAN Tyrosine-protein phosphatase non-receptor type 4 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 4 that is encoded in the genome of human.


name: T2EA_HUMAN General transcription factor IIE subunit 1 (sprot)

description: A general transcription factor IIE subunit 1 that is encoded in the genome of human.


name: T2EB_HUMAN Transcription initiation factor IIE subunit beta (sprot)

description: A transcription initiation factor IIE subunit beta that is encoded in the genome of human.


name: NEC1_HUMAN Neuroendocrine convertase 1 (sprot)

description: A neuroendocrine convertase 1 that is encoded in the genome of human.


response to chlorate

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus.


name: PCSK6_HUMAN Proprotein convertase subtilisin/kexin type 6 (sprot)

description: A proprotein convertase subtilisin/kexin type 6 that is encoded in the genome of human.


name: zygotic determination of anterior/posterior axis, embryo

description: The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade.


name: TPP2_HUMAN Tripeptidyl-peptidase 2 (sprot)

description: A tripeptidyl-peptidase 2 that is encoded in the genome of human.


intracellular amino acid homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of amino acids within a cell.


name: IMPA1_HUMAN Inositol monophosphatase 1 (sprot)

description: An inositol monophosphatase 1 that is encoded in the genome of human.


name: inositol monophosphate phosphatase activity

description: Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate.


name: AA2AR_HUMAN Adenosine receptor A2a (sprot)

description: An adenosine receptor A2a that is encoded in the genome of human.


name: G protein-coupled adenosine receptor activity

description: Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


name: positive regulation of circadian sleep/wake cycle, sleep

description: Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.


name: negative regulation of alpha-beta T cell activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation.


name: AA2BR_HUMAN Adenosine receptor A2b (sprot)

description: An adenosine receptor A2b that is encoded in the genome of human.


name: positive regulation of chronic inflammatory response to non-antigenic stimulus

description: Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.


CCN2_HUMAN CCN family member 2 (sprot)

A CCN family member 2 that is encoded in the genome of human.


name: EPHA2_HUMAN Ephrin type-A receptor 2 (sprot)

description: An ephrin type-A receptor 2 that is encoded in the genome of human.


notochord cell development

description: The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.


name: negative regulation of lymphangiogenesis

description: Any process that stops, prevents or reduces the frequency, rate or extent of lymphangiogenesis.


name: EPHA3_HUMAN Ephrin type-A receptor 3 (sprot)

description: An ephrin type-A receptor 3 that is encoded in the genome of human.


fasciculation of sensory neuron axon

description: The collection of sensory neuron axons into a bundle of rods, known as a fascicle.


fasciculation of motor neuron axon

description: The collection of motor neuron axons into a bundle of rods, known as a fascicle.


name: EPHA8_HUMAN Ephrin type-A receptor 8 (sprot)

description: An ephrin type-A receptor 8 that is encoded in the genome of human.


name: EPHB2_HUMAN Ephrin type-B receptor 2 (sprot)

description: An ephrin type-B receptor 2 that is encoded in the genome of human.


hindbrain tangential cell migration

description: The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration.


name: positive regulation of synaptic plasticity

description: A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.


regulation of body fluid levels

description: Any process that modulates the levels of body fluids.


name: trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission

description: Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse.


neuron projection retraction

description: The organization process which results in the disassembly (either partial or complete) of constituent parts of a neuron projection. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.


description: A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane.


name: negative regulation of NMDA glutamate receptor activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of NMDA glutamate receptor activity.


name: regulation of T-helper 17 type immune response

description: Any process that modulates the frequency, rate or extent of T-helper 17 type immune response.


name: PTN6_HUMAN Tyrosine-protein phosphatase non-receptor type 6 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 6 that is encoded in the genome of human.


name: negative regulation of humoral immune response mediated by circulating immunoglobulin

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.


regulation of B cell differentiation

description: Any process that modulates the frequency, rate or extent of B cell differentiation.


name: SHC1_HUMAN SHC-transforming protein 1 (sprot)

description: An shc-transforming protein 1 that is encoded in the genome of human.


name: NK3R_HUMAN Neuromedin-K receptor (sprot)

description: A neuromedin-K receptor that is encoded in the genome of human.


name: 3MG_HUMAN DNA-3-methyladenine glycosylase (sprot)

description: A DNA-3-methyladenine glycosylase that is encoded in the genome of human.


description: Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site.


description: Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site.


description: Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site.


description: Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site.


name: RABP2_HUMAN Cellular retinoic acid-binding protein 2 (sprot)

description: A cellular retinoic acid-binding protein 2 that is encoded in the genome of human.


name: ARI4A_HUMAN AT-rich interactive domain-containing protein 4A (sprot)

description: An AT-rich interactive domain-containing protein 4A that is encoded in the genome of human.


name: KDM5A_HUMAN Lysine-specific demethylase 5A (sprot)

description: A lysine-specific demethylase 5A that is encoded in the genome of human.


name: histone H3K4me/H3K4me2/H3K4me3 demethylase activity

description: Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


facultative heterochromatin formation

description: The compaction of chromatin into a conformation that is refactory to transcription but that be converted to euchromatin and allow transcription in specific contexts. These can be temporal (e.g., developmental states or specific cell-cycle stages), spatial (e.g., nuclear localization changes from the center to the periphery or vice versa due to exogenous factors/signals), or parental/heritable (e.g., monoallelic gene expression).


name: LTK_HUMAN Leukocyte tyrosine kinase receptor (sprot)

description: A leukocyte tyrosine kinase receptor that is encoded in the genome of human.


S100G_HUMAN Protein S100-G (sprot)

A protein S100-G that is encoded in the genome of human.


name: CO4A5_HUMAN Collagen alpha-5(IV) chain (sprot)

description: A collagen alpha-5(IV) chain that is encoded in the genome of human.


TKT_HUMAN Transketolase (sprot)

A transketolase that is encoded in the genome of human.


transketolase activity

description: Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor.


name: pentose-phosphate shunt, non-oxidative branch

description: The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P.


description: The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis.


name: xylulose 5-phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of xylulose 5-phosphate.


name: IL12A_HUMAN Interleukin-12 subunit alpha (sprot)

description: An interleukin-12 subunit alpha that is encoded in the genome of human.


interleukin-12 beta subunit binding

description: Binding to the beta subunit of interleukin-12.


interleukin-27 binding

description: Binding to interleukin-27.


name: positive regulation of NK T cell activation

description: Any process that activates or increases the frequency, rate or extent of natural killer T cell activation.


late endosome lumen

description: The volume enclosed by the membrane of a late endosome.


interleukin-12 complex

description: A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.


name: IL12B_HUMAN Interleukin-12 subunit beta (sprot)

description: An interleukin-12 subunit beta that is encoded in the genome of human.


interleukin-23 receptor binding

description: Binding to an interleukin-23 receptor.


interleukin-12 alpha subunit binding

description: Binding to the alpha subunit of interleukin-12.


name: natural killer cell activation involved in immune response

description: The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


name: positive regulation of tissue remodeling

description: Any process that activates or increases the frequency, rate, or extent of tissue remodeling.


T-helper cell differentiation

description: The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell.


name: regulation of tyrosine phosphorylation of STAT protein

description: Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


interleukin-23 complex

description: A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space.


CASP1_HUMAN Caspase-1 (sprot)

A caspase-1 that is encoded in the genome of human.


name: signaling receptor ligand precursor processing

description: The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand.


NLRP1 inflammasome complex

description: An inflammasome complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential.


IPAF inflammasome complex

description: An inflammasome complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri.


protease inhibitor complex

description: A heterodimeric protein complex that contains a protease inhibitor and a protease; formation of the complex inhibits protease activity.


name: NOS3_HUMAN Nitric oxide synthase 3 (sprot)

description: A nitric oxide synthase 3 that is encoded in the genome of human.


nitric-oxide synthase activity

description: Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.


FMN binding

description: Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.


name: regulation of the force of heart contraction by chemical signal

description: The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.


name: negative regulation of muscle hyperplasia

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hyperplasia.


name: positive regulation of guanylate cyclase activity

description: Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.


name: NOS1_HUMAN Nitric oxide synthase 1 (sprot)

description: A nitric oxide synthase 1 that is encoded in the genome of human.


negative regulation of serotonin uptake

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell.


name: positive regulation of sodium ion transmembrane transport

description: Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport.


SPB3_HUMAN Serpin B3 (sprot)

A serpin B3 that is encoded in the genome of human.


name: positive regulation of endopeptidase activity

description: Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.


LMOD1_HUMAN Leiomodin-1 (sprot)

A leiomodin-1 that is encoded in the genome of human.


actin nucleation

description: The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.


name: RBMS1_HUMAN RNA-binding motif, single-stranded-interacting protein 1 (sprot)

description: An RNA-binding motif, single-stranded-interacting protein 1 that is encoded in the genome of human.


PML_HUMAN Protein PML (sprot)

A transcription factor PML that is encoded in the genome of human.


name: regulation of calcium ion transport into cytosol

description: Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.


name: positive regulation of peptidyl-lysine acetylation

description: Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation.


name: TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (sprot)

description: A non-receptor tyrosine-protein kinase TYK2 that is encoded in the genome of human.


KAIN_HUMAN Kallistatin (sprot)

A kallistatin that is encoded in the genome of human.


name: EF1D_HUMAN Elongation factor 1-delta (sprot)

description: An elongation factor 1-delta that is encoded in the genome of human.


name: OAS2_HUMAN 2'-5'-oligoadenylate synthase 2 (sprot)

description: A 2'-5'-oligoadenylate synthase 2 that is encoded in the genome of human.


regulation of lactation

description: Any process that modulates the frequency, rate or extent of lactation.


name: RABP1_HUMAN Cellular retinoic acid-binding protein 1 (sprot)

description: A cellular retinoic acid-binding protein 1 that is encoded in the genome of human.


name: ODPAT_HUMAN Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (sprot)

description: A pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial that is encoded in the genome of human.


CD40L_HUMAN CD40 ligand (sprot)

A tumor necrosis factor ligand superfamily member 5 that is encoded in the genome of human.


CD40 receptor binding

description: Binding to CD40, a receptor found on the surface of all B-lymphocytes.


name: MARCS_HUMAN Myristoylated alanine-rich C-kinase substrate (sprot)

description: A myristoylated alanine-rich C-kinase substrate that is encoded in the genome of human.


AQP1_HUMAN Aquaporin-1 (sprot)

An aquaporin-1 that is encoded in the genome of human.


name: intracellularly cGMP-activated cation channel activity

description: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts.


name: potassium ion transmembrane transporter activity

description: Enables the transfer of potassium ions (K+) from one side of a membrane to the other.


name: glycerol transmembrane transporter activity

description: Enables the transfer of glycerol from one side of a membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.


name: nitric oxide transmembrane transporter activity

description: Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other.


name: carbon dioxide transmembrane transporter activity

description: Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other.


renal water transport

description: The directed movement of water (H2O) by the renal system.


cerebrospinal fluid secretion

description: The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces.


carbon dioxide transmembrane transport

description: The process in which carbon dioxide (CO2) is transported across a membrane.


lipid digestion

description: The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.


positive regulation of saliva secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of saliva.


corticotropin secretion

description: The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus.


cellular response to mercury ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.


name: metanephric descending thin limb development

description: The process whose specific outcome is the progression of the metanephric descending thin limb over time, from its formation to the mature structure. The metanephric descending thin limb is a part of the metanephric loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the metanephric loop of Henle.


name: metanephric proximal straight tubule development

description: The process whose specific outcome is the progression of the metanephric proximal straight tubule over time, from its formation to the mature structure. The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule.


name: metanephric proximal convoluted tubule segment 2 development

description: The process whose specific outcome is the progression of the S2 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the metanephric proximal tubule is involved in reabsorption of water and sodium chloride.


name: metanephric glomerulus vasculature development

description: The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus.


name: CNGA1_HUMAN Cyclic nucleotide-gated channel alpha-1 (sprot)

description: A cGMP-gated cation channel alpha-1 that is encoded in the genome of human.


name: GNA11_HUMAN Guanine nucleotide-binding protein subunit alpha-11 (sprot)

description: A guanine nucleotide-binding protein subunit alpha-11 that is encoded in the genome of human.


name: regulation of melanocyte differentiation

description: Any process that modulates the frequency, rate or extent of melanocyte differentiation.


name: AL4A1_HUMAN Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (sprot)

description: A delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial that is encoded in the genome of human.


name: PBLD_HUMAN Phenazine biosynthesis-like domain-containing protein (sprot)

description: A phenazine biosynthesis-like domain-containing protein that is encoded in the genome of human.


name: ERP29_HUMAN Endoplasmic reticulum resident protein 29 (sprot)

description: An endoplasmic reticulum resident protein 29 that is encoded in the genome of human.


name: regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

description: Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.


PRDX6_HUMAN Peroxiredoxin-6 (sprot)

A peroxiredoxin-6 that is encoded in the genome of human.


description: Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA.


peroxiredoxin activity

description: Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.


name: BLVRB_HUMAN Flavin reductase (NADPH) (sprot)

description: A flavin reductase that is encoded in the genome of human.


biliverdin reductase (NAD(P)H) activity

description: Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+.


FMN reductase (NAD(P)H) activity

description: Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates.


riboflavin reductase (NADPH) activity

description: Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+.


FMN reductase (NADPH) activity

description: Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+.


FMN reductase (NADH) activity

description: Catalysis of the reaction: FMNH2 + NAD+ = FMN + NADH + 2 H+.


biliberdin reductase NAD+ activity

description: Catalysis of the reaction: bilirubin + NAD+ = biliverdin + NADH+ H+.


biliverdin reductase (NADPH) activity

description: Catalysis of the reaction: bilirubin + NADP+ = biliverdin + NADPH + H+.


name: PRDX5_HUMAN Peroxiredoxin-5, mitochondrial (sprot)

description: A peroxiredoxin-5, mitochondrial that is encoded in the genome of human.


name: RNA polymerase III transcription regulatory region sequence-specific DNA binding

description: Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.


name: negative regulation of transcription by RNA polymerase III

description: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III.


name: DOPD_HUMAN D-dopachrome decarboxylase (sprot)

description: A D-dopachrome decarboxylase that is encoded in the genome of human.


D-dopachrome decarboxylase activity

description: Catalysis of the reaction: D-dopachrome + H+ = 5,6-dihydroxyindole + CO2.


name: GFRP_HUMAN GTP cyclohydrolase 1 feedback regulatory protein (sprot)

description: A GTP cyclohydrolase 1 feedback regulatory protein that is encoded in the genome of human.


name: PRDX3_HUMAN Thioredoxin-dependent peroxide reductase, mitochondrial (sprot)

description: A thioredoxin-dependent peroxide reductase, mitochondrial that is encoded in the genome of human.


alkyl hydroperoxide reductase activity

description: Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol.


peptidyl-cysteine oxidation

description: The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid.


name: ATPD_HUMAN ATP synthase subunit delta, mitochondrial (sprot)

description: An ATP synthase subunit delta, mitochondrial that is encoded in the genome of human.


name: mitochondrial proton-transporting ATP synthase complex assembly

description: The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane.


name: mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

description: The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled.


name: RL12_HUMAN Large ribosomal subunit protein uL11 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL11 that is encoded in the genome of human.


name: ECHM_HUMAN Enoyl-CoA hydratase, mitochondrial (sprot)

description: An enoyl-CoA hydratase, mitochondrial that is encoded in the genome of human.


description: Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.


enoyl-CoA hydratase activity

description: Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O.


description: Catalysis of the reaction: 3-hydroxypropionyl-CoA = acryloyl-CoA + H2O.


crotonyl-CoA hydratase activity

description: Catalysis of the reaction: Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.


KCY_HUMAN UMP-CMP kinase (sprot)

A UMP-CMP kinase that is encoded in the genome of human.


uridine kinase activity

description: Catalysis of the reaction: ATP + uridine = ADP + UMP.


UMP kinase activity

description: Catalysis of the reaction: ATP + UMP = ADP + UDP.


CMP kinase activity

description: Catalysis of the reaction: ATP + CMP = ADP + CDP.


dCMP kinase activity

description: Catalysis of the reaction: ATP + dCMP = ADP + dCDP.


name: pyrimidine ribonucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


name: PEBP1_HUMAN Phosphatidylethanolamine-binding protein 1 (sprot)

description: A phosphatidylethanolamine-binding protein 1 that is encoded in the genome of human.


name: PDIA3_HUMAN Protein disulfide-isomerase A3 (sprot)

description: A protein disulfide-isomerase A3 that is encoded in the genome of human.


name: 2AAA_HUMAN Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (sprot)

description: A serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform that is encoded in the genome of human.


meiotic spindle elongation

description: The lengthening of the distance between poles of the spindle during a meiotic cell cycle.


mitotic sister chromatid separation

description: The process in which sister chromatids are physically detached from each other during mitosis.


name: regulation of meiotic cell cycle process involved in oocyte maturation

description: Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.


protein phosphatase type 2A complex

description: A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.


name: 2AAB_HUMAN Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (sprot)

description: A serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform that is encoded in the genome of human.


name: CD6_HUMAN T-cell differentiation antigen CD6 (sprot)

description: A CD6 molecule that is encoded in the genome of human.


name: CDC27_HUMAN Cell division cycle protein 27 homolog (sprot)

description: A cell division cycle protein 27 that is encoded in the genome of human.


regulation of meiotic cell cycle

description: Any process that modulates the rate or extent of progression through the meiotic cell cycle.


name: FCERG_HUMAN High affinity immunoglobulin epsilon receptor subunit gamma (sprot)

description: A high affinity immunoglobulin epsilon receptor subunit gamma that is encoded in the genome of human.


name: CCND2_HUMAN G1/S-specific cyclin-D2 (sprot)

description: A G1/S-specific cyclin-D2 that is encoded in the genome of human.


name: CCND3_HUMAN G1/S-specific cyclin-D3 (sprot)

description: A G1/S-specific cyclin-D3 that is encoded in the genome of human.


cyclin D3-CDK6 complex

description: A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


name: WEE1_HUMAN Wee1-like protein kinase (sprot)

description: A Wee1-like protein kinase that is encoded in the genome of human.


name: MIP_HUMAN Lens fiber major intrinsic protein (sprot)

description: A lens fiber major intrinsic protein that is encoded in the genome of human.


name: MPIP1_HUMAN M-phase inducer phosphatase 1 (sprot)

description: An M-phase inducer phosphatase 1 that is encoded in the genome of human.


name: MPIP2_HUMAN M-phase inducer phosphatase 2 (sprot)

description: An M-phase inducer phosphatase 2 that is encoded in the genome of human.


name: MPIP3_HUMAN M-phase inducer phosphatase 3 (sprot)

description: An M-phase inducer phosphatase 3 that is encoded in the genome of human.


WW domain binding

description: Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.


name: PPIF_HUMAN Peptidyl-prolyl cis-trans isomerase F, mitochondrial (sprot)

description: A peptidyl-prolyl cis-trans isomerase F, mitochondrial that is encoded in the genome of human.


name: regulation of proton-transporting ATPase activity, rotational mechanism

description: Any process that modulates the rate of ATP hydrolysis by an ATPase. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.


name: regulation of mitochondrial membrane permeability involved in programmed necrotic cell death

description: Any regulation of mitochondrial membrane permeability that is involved in programmed necrotic cell death.


name: mitochondrial outer membrane permeabilization involved in programmed cell death

description: The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process.


name: negative regulation of oxidative phosphorylation uncoupler activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of oxidative phosphorylation uncoupler activity.


name: T4S1_HUMAN Transmembrane 4 L6 family member 1 (sprot)

description: A transmembrane 4 L6 family member 1 that is encoded in the genome of human.


name: BKRB2_HUMAN B2 bradykinin receptor (sprot)

description: A B2 bradykinin receptor that is encoded in the genome of human.


bradykinin receptor activity

description: Combining with bradykinin to initiate a change in cell activity.


name: negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator

description: Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator.


name: intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator

description: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of osmotic stress, and ends when the execution phase of apoptosis is triggered.


name: NKTR_HUMAN NK-tumor recognition protein (sprot)

description: An NK-tumor recognition protein that is encoded in the genome of human.


name: NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (sprot)

description: A glycylpeptide N-tetradecanoyltransferase 1 that is encoded in the genome of human.


myristoyltransferase activity

description: Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule.


name: HLAF_HUMAN HLA class I histocompatibility antigen, alpha chain F (sprot)

description: An MHC class I histocompatibility antigen, alpha chain F that is encoded in the genome of human.


name: negative regulation of natural killer cell cytokine production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production.


name: negative regulation of natural killer cell degranulation

description: Any process that stops, prevents, or reduces the rate of natural killer cell degranulation.


name: V2R_HUMAN Vasopressin V2 receptor (sprot)

description: A vasopressin V2 receptor that is encoded in the genome of human.


vasopressin receptor activity

description: Combining with vasopressin to initiate a change in cell activity.


renal water retention

description: The process in which renal water excretion is decreased.


HMOX2_HUMAN Heme oxygenase 2 (sprot)

A heme oxygenase 2 that is encoded in the genome of human.


name: PURA2_HUMAN Adenylosuccinate synthetase isozyme 2 (sprot)

description: An adenylosuccinate synthetase isozyme 2 that is encoded in the genome of human.


adenylosuccinate synthase activity

description: Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H+ + phosphate.


AMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate.


response to ammonium ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus.


name: UFO_HUMAN Tyrosine-protein kinase receptor UFO (sprot)

description: A tyrosine-protein kinase receptor UFO that is encoded in the genome of human.


forebrain cell migration

description: The orderly movement of a cell from one site to another at least one of which is located in the forebrain.


positive regulation of pinocytosis

description: Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.


name: negative regulation of lymphocyte activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation.


name: SC6A1_HUMAN Sodium- and chloride-dependent GABA transporter 1 (sprot)

description: A sodium- and chloride-dependent GABA transporter 1 that is encoded in the genome of human.


name: gamma-aminobutyric acid:sodium:chloride symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in).


name: sodium:chloride symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in).


name: positive regulation of gamma-aminobutyric acid secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid.


gamma-aminobutyric acid reuptake

description: The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.


name: inorganic anion import across plasma membrane

description: The directed movement of inorganic anions from outside of a cell, across the plasma membrane and into the cytosol.


name: ACHA5_HUMAN Neuronal acetylcholine receptor subunit alpha-5 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-5 that is encoded in the genome of human.


name: AMRP_HUMAN Alpha-2-macroglobulin receptor-associated protein (sprot)

description: An alpha-2-macroglobulin receptor-associated protein that is encoded in the genome of human.


name: regulation of receptor-mediated endocytosis

description: Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.


name: extracellular negative regulation of signal transduction

description: Any negative regulation of signal transduction that takes place in extracellular region.


benzodiazepine receptor activity

description: Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity.


contact inhibition

description: The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal, resulting in the cessation of cell growth or proliferation.


name: negative regulation of ATP metabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process.


name: negative regulation of corticosterone secretion

description: Any process that stops, prevents or reduces the frequency, rate or extent of corticosterone secretion.


name: AA1R_HUMAN Adenosine receptor A1 (sprot)

description: An adenosine receptor A1 that is encoded in the genome of human.


purine nucleoside binding

description: Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose.


regulation of glomerular filtration

description: Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule.


name: negative regulation of glutamate secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate.


name: positive regulation of nucleoside transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: negative regulation of neurotrophin production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin.


name: negative regulation of circadian sleep/wake cycle, non-REM sleep

description: Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep.


name: negative regulation of long-term synaptic depression

description: Any process that stops, prevents or reduces the frequency, rate or extent of long term synaptic depression.


name: GRPR_HUMAN Gastrin-releasing peptide receptor (sprot)

description: A gastrin-releasing peptide receptor that is encoded in the genome of human.


name: AGTR1_HUMAN Type-1 angiotensin II receptor (sprot)

description: An angiotensin II receptor 1 that is encoded in the genome of human.


angiotensin type I receptor activity

description: An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms.


name: positive regulation of phospholipase A2 activity

description: Any process that activates or increases the activity of the enzyme phospholipase A2.


name: phospholipase C-activating angiotensin-activated signaling pathway

description: A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by angiotensin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


OXYR_HUMAN Oxytocin receptor (sprot)

An oxytocin receptor that is encoded in the genome of human.


response to anoxia

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%.


name: PUR8_HUMAN Adenylosuccinate lyase (sprot)

description: An adenylosuccinate lyase that is encoded in the genome of human.


name: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity

description: Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.


name: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity

description: Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.


KPYR_HUMAN Pyruvate kinase PKLR (sprot)

A pyruvate kinase PKLR that is encoded in the genome of human.


name: CLIP1_HUMAN CAP-Gly domain-containing linker protein 1 (sprot)

description: A CAP-Gly domain-containing linker protein 1 that is encoded in the genome of human.


microtubule plus-end

description: The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability.


macropinosome

description: A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis.


SORCN_HUMAN Sorcin (sprot)

A sorcin that is encoded in the genome of human.


intracellular sequestering of iron ion

description: The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system.


name: GNA15_HUMAN Guanine nucleotide-binding protein subunit alpha-15 (sprot)

description: A guanine nucleotide-binding protein subunit alpha-15 that is encoded in the genome of human.


name: GSTT1_HUMAN Glutathione S-transferase theta-1 (sprot)

description: A glutathione S-transferase theta-1 that is encoded in the genome of human.


name: ILEU_HUMAN Leukocyte elastase inhibitor (sprot)

description: A leukocyte elastase inhibitor that is encoded in the genome of human.


GCH1_HUMAN GTP cyclohydrolase 1 (sprot)

A GTP cyclohydrolase 1 that is encoded in the genome of human.


GTP cyclohydrolase I activity

description: Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+.


regulation of lung blood pressure

description: The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure.


name: pteridine-containing compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.


name: CTR1_HUMAN High affinity cationic amino acid transporter 1 (sprot)

description: A high affinity cationic amino acid transporter 1 that is encoded in the genome of human.


name: L-ornithine transmembrane transporter activity

description: Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid.


name: L-histidine transmembrane transporter activity

description: Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid.


name: L-lysine transmembrane transporter activity

description: Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid.


L-amino acid transport

description: The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


lysine transport

description: The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


ornithine transport

description: The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


L-ornithine transmembrane transport

description: The directed movement of L-ornithine across a membrane.


name: L-histidine import across plasma membrane

description: The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol.


name: AL1B1_HUMAN Aldehyde dehydrogenase X, mitochondrial (sprot)

description: An aldehyde dehydrogenase X, mitochondrial that is encoded in the genome of human.


name: AL3A1_HUMAN Aldehyde dehydrogenase, dimeric NADP-preferring (sprot)

description: An aldehyde dehydrogenase, dimeric NADP-preferring that is encoded in the genome of human.


name: benzaldehyde dehydrogenase (NAD+) activity

description: Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+.


name: SSR1_HUMAN Somatostatin receptor type 1 (sprot)

description: A somatostatin receptor type 1 that is encoded in the genome of human.


somatostatin receptor activity

description: Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28).