name: multicellular organismal reproductive process

description: The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.


somatotropin secreting cell development

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.


name: GCNT1_HUMAN Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (sprot)

description: A beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase that is encoded in the genome of human.


O-glycan processing, core 2

description: The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-(1->6)[Gal-beta-(1->3)]-GalNAc.


GUC2A_HUMAN Guanylin (sprot)

A guanylin that is encoded in the genome of human.


guanylate cyclase activator activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binds to and increases the activity of guanylate cyclase.


name: MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (sprot)

description: A dual specificity mitogen-activated protein kinase kinase 1 that is encoded in the genome of human.


name: TIE2_HUMAN Angiopoietin-1 receptor (sprot)

description: An angiopoietin-1 receptor that is encoded in the genome of human.


name: regulation of establishment or maintenance of cell polarity

description: Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.


name: M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 (sprot)

description: A mitogen-activated protein kinase kinase kinase 10 that is encoded in the genome of human.


name: FKBP4_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP4 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP4 that is encoded in the genome of human.


name: steroid hormone receptor complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor.


name: negative regulation of microtubule polymerization or depolymerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.


male sex differentiation

description: The establishment of the sex of a male organism by physical differentiation.


name: PLOD1_HUMAN Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (sprot)

description: A procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 that is encoded in the genome of human.


MUC2_HUMAN Mucin-2 (sprot)

A mucin-2 that is encoded in the genome of human.


detoxification of copper ion

description: Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion.


inner mucus layer

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria.


outer mucus layer

description: The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria.


NUCB1_HUMAN Nucleobindin-1 (sprot)

A nucleobindin-1 that is encoded in the genome of human.


name: RASF7_HUMAN Ras association domain-containing protein 7 (sprot)

description: A Ras association domain-containing protein 7 that is encoded in the genome of human.


name: GUC2D_HUMAN Retinal guanylyl cyclase 1 (sprot)

description: A retinal guanylyl cyclase 1 that is encoded in the genome of human.


name: RL6_HUMAN Large ribosomal subunit protein eL6 (sprot)

description: A large ribosomal subunit protein eL6 that is encoded in the genome of human.


name: TOP2B_HUMAN DNA topoisomerase 2-beta (sprot)

description: A DNA topoisomerase 2-beta that is encoded in the genome of human.


name: CP4AB_HUMAN Cytochrome P450 4A11 (sprot)

description: A cytochrome P450 4A11 that is encoded in the genome of human.


oxylipin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.


name: CREB5_HUMAN Cyclic AMP-responsive element-binding protein 5 (sprot)

description: A cyclic AMP-responsive element-binding protein 5 that is encoded in the genome of human.


name: AKA12_HUMAN A-kinase anchor protein 12 (sprot)

description: An A-kinase anchor protein 12 that is encoded in the genome of human.


name: regulation of protein kinase C signaling

description: Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.


name: positive regulation of oligodendrocyte apoptotic process

description: Any process that activates or increases the frequency, rate or extent of oligodendrocyte apoptotic process.


name: PAX2_HUMAN Paired box protein Pax-2 (sprot)

description: A paired box protein Pax-2 that is encoded in the genome of human.


pronephric field specification

description: The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop.


optic chiasma development

description: The developmental process pertaining to the progression of the optic chiasm from its initial formation to the mature structure. The process begins when the pathfinding of the axons of the developing optic nerve cause some axons to cross at the midline of the brain and ends when the axons are mature.


name: negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

description: Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros.


name: negative regulation of apoptotic process involved in metanephric collecting duct development

description: Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development.


name: negative regulation of apoptotic process involved in metanephric nephron tubule development

description: Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development.


name: positive regulation of metanephric DCT cell differentiation

description: Any process that activates or increases the frequency, rate or extent of metanephric DCT cell differentiation.


name: positive regulation of optic nerve formation

description: Any process that activates or increases the frequency, rate or extent of optic nerve formation.


name: M2OM_HUMAN Mitochondrial 2-oxoglutarate/malate carrier protein (sprot)

description: A mitochondrial 2-oxoglutarate/malate carrier protein that is encoded in the genome of human.


name: oxoglutarate:malate antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out).


alpha-ketoglutarate transport

description: The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: FHR3_HUMAN Complement factor H-related protein 3 (sprot)

description: A complement factor H-related protein 3 that is encoded in the genome of human.


DYST_HUMAN Dystonin (sprot)

A dystonin that is encoded in the genome of human.


H zone

description: A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments.


name: GSTM4_HUMAN Glutathione S-transferase Mu 4 (sprot)

description: A glutathione S-transferase mu 4 that is encoded in the genome of human.


name: HHEX_HUMAN Hematopoietically-expressed homeobox protein HHEX (sprot)

description: A hematopoietically-expressed homeobox protein HHEX that is encoded in the genome of human.


regulation of leukocyte proliferation

description: Any process that modulates the frequency, rate or extent of leukocyte proliferation.


name: PO3F1_HUMAN POU domain, class 3, transcription factor 1 (sprot)

description: A POU domain, class 3, transcription factor 1 that is encoded in the genome of human.


name: CREM_HUMAN cAMP-responsive element modulator (sprot)

description: A cAMP-responsive element modulator that is encoded in the genome of human.


ENL_HUMAN Protein ENL (sprot)

A protein ENL that is encoded in the genome of human.


name: MECOM_HUMAN Histone-lysine N-methyltransferase MECOM (sprot)

description: A histone-lysine N-methyltransferase MECOM that is encoded in the genome of human.


name: histone H3K9me2 methyltransferase activity

description: Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3.


name: histone H3K9 monomethyltransferase activity

description: Catalysis of the reaction: L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me.


name: GNA12_HUMAN Guanine nucleotide-binding protein subunit alpha-12 (sprot)

description: A guanine nucleotide-binding protein subunit alpha-12 that is encoded in the genome of human.


CAV1_HUMAN Caveolin-1 (sprot)

A caveolin-1 that is encoded in the genome of human.


name: inward rectifier potassium channel inhibitor activity

description: Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel.


intracellular nitric oxide homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of nitric oxide within a cell.


name: protein localization to plasma membrane raft

description: A process in which a protein is transported to, or maintained in, a location within a plasma membrane raft.


regulation of peptidase activity

description: Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.


name: negative regulation of protein tyrosine kinase activity

description: Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity.


name: negative regulation of peptidyl-tyrosine autophosphorylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.


name: negative regulation of inward rectifier potassium channel activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of inward rectifier potassium channel activity.


ACY1_HUMAN Aminoacylase-1 (sprot)

An aminoacylase-1 that is encoded in the genome of human.


name: KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (sprot)

description: A histone-lysine N-methyltransferase 2A that is encoded in the genome of human.


description: Catalysis of the reaction: L-cysteinyl-[protein] + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein].


name: negative regulation of DNA methylation-dependent heterochromatin formation

description: Any process that decreases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation.


name: TGBR3_HUMAN Transforming growth factor beta receptor type 3 (sprot)

description: A TGF-beta receptor type-3 that is encoded in the genome of human.


name: transforming growth factor beta receptor activity, type III

description: Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors.


name: transforming growth factor beta receptor complex assembly

description: The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex.


definitive erythrocyte differentiation

description: Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis.


name: epicardium-derived cardiac fibroblast cell development

description: The process whose specific outcome is the progression of an epicardial-derived cardiac fibroblast over time, from its formation to the mature state. A epicardial-derived cardiac fibroblast is a connective tissue cell of the heart that arises from the epicardium and secretes an extracellular matrix rich in collagen and other macromolecules.


name: TNAP2_HUMAN Tumor necrosis factor alpha-induced protein 2 (sprot)

description: A tumor necrosis factor alpha-induced protein 2 that is encoded in the genome of human.


name: PPARD_HUMAN Peroxisome proliferator-activated receptor delta (sprot)

description: A peroxisome proliferator-activated receptor delta that is encoded in the genome of human.


linoleic acid binding

description: Binding to linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid.


name: positive regulation of fat cell proliferation

description: Any process that activates or increases the rate or extent of fat cell proliferation.


name: CENPC_HUMAN Centromere protein C (sprot)

description: A centromere protein C that is encoded in the genome of human.


LMNB2_HUMAN Lamin-B2 (sprot)

A lamin-B2 that is encoded in the genome of human.


name: PTPS_HUMAN 6-pyruvoyl tetrahydrobiopterin synthase (sprot)

description: A 6-pyruvoyl tetrahydrobiopterin synthase that is encoded in the genome of human.


description: Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H+ + triphosphate.


name: ROM1_HUMAN Rod outer segment membrane protein 1 (sprot)

description: A rod outer segment membrane protein 1 that is encoded in the genome of human.


TFF2_HUMAN Trefoil factor 2 (sprot)

A trefoil factor 2 that is encoded in the genome of human.


name: UPAR_HUMAN Urokinase plasminogen activator surface receptor (sprot)

description: A urokinase plasminogen activator surface receptor that is encoded in the genome of human.


name: urokinase plasminogen activator receptor activity

description: Combining with the urokinase plasminogen activator to initiate a change in cell activity.


KIME_HUMAN Mevalonate kinase (sprot)

A mevalonate kinase that is encoded in the genome of human.


mevalonate kinase activity

description: Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H+.


name: isopentenyl diphosphate biosynthetic process, mevalonate pathway

description: The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.


name: PTH1R_HUMAN Parathyroid hormone/parathyroid hormone-related peptide receptor (sprot)

description: A parathyroid hormone/parathyroid hormone-related peptide receptor that is encoded in the genome of human.


parathyroid hormone receptor activity

description: Combining with parathyroid hormone to initiate a change in cell activity.


name: ERCC6_HUMAN DNA excision repair protein ERCC-6 (sprot)

description: A DNA excision repair protein ERCC-6 that is encoded in the genome of human.


name: TAP1_HUMAN Antigen peptide transporter 1 (sprot)

description: An antigen peptide transporter 1 that is encoded in the genome of human.


name: peptide transmembrane transporter activity

description: Enables the transfer of a peptide from one side of a membrane to the other.


name: ABC-type peptide antigen transporter activity

description: Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate.


name: cytosol to endoplasmic reticulum transport

description: The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell.


TAP complex

description: A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum.


name: TAP2_HUMAN Antigen peptide transporter 2 (sprot)

description: An antigen peptide transporter 2 that is encoded in the genome of human.


tapasin binding

description: Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules.


name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent

description: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.


peptide antigen transport

description: The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.


name: FHR1_HUMAN Complement factor H-related protein 1 (sprot)

description: A complement factor H-related protein 1 that is encoded in the genome of human.


name: COAA1_HUMAN Collagen alpha-1(X) chain (sprot)

description: A collagen alpha-1(X) chain that is encoded in the genome of human.


collagen type X trimer

description: A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets).


name: CEBPZ_HUMAN CCAAT/enhancer-binding protein zeta (sprot)

description: A CCAAT/enhancer-binding protein zeta that is encoded in the genome of human.


name: KCNC4_HUMAN Potassium voltage-gated channel subfamily C member 4 (sprot)

description: A voltage-gated potassium channel KCNC4 that is encoded in the genome of human.


name: EVX2_HUMAN Homeobox even-skipped homolog protein 2 (sprot)

description: A homeobox even-skipped homolog protein 2 that is encoded in the genome of human.


name: ZNF85_HUMAN Zinc finger protein 85 (sprot)

description: A zinc finger protein 85 that is encoded in the genome of human.


name: ZN117_HUMAN Zinc finger protein 117 (sprot)

description: A zinc finger protein 117 that is encoded in the genome of human.


name: HSF2_HUMAN Heat shock factor protein 2 (sprot)

description: A heat shock factor protein 2 that is encoded in the genome of human.


name: ZNF92_HUMAN Zinc finger protein 92 (sprot)

description: A zinc finger protein 92 that is encoded in the genome of human.


name: ZNF90_HUMAN Zinc finger protein 90 (sprot)

description: A zinc finger protein 90 that is encoded in the genome of human.


name: ARI5A_HUMAN AT-rich interactive domain-containing protein 5A (sprot)

description: An AT-rich interactive domain-containing protein 5A that is encoded in the genome of human.


name: PRB3_HUMAN Basic salivary proline-rich protein 3 (sprot)

description: A basic salivary proline-rich protein 3 that is encoded in the genome of human.


name: TF65_HUMAN Transcription factor p65 (sprot)

description: A transcription factor p65 that is encoded in the genome of human.


acetaldehyde metabolic process

description: The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol.


name: postsynapse to nucleus signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).


NF-kappaB p50/p65 complex

description: A heterodimer of NF-kappa B p50 and p65 subunits.


name: UBXN1_HUMAN UBX domain-containing protein 1 (sprot)

description: A UBX domain-containing protein 1 that is encoded in the genome of human.


name: K6-linked polyubiquitin modification-dependent protein binding

description: Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein.


proteasome regulatory particle binding

description: Binding to a proteasome regulatory particle.


name: negative regulation of protein K48-linked deubiquitination

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein K48-linked deubiquitination.


name: negative regulation of ubiquitin-specific protease activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity.


name: GLGB_HUMAN 1,4-alpha-glucan-branching enzyme (sprot)

description: A 1,4-alpha-glucan-branching enzyme that is encoded in the genome of human.


name: 1,4-alpha-glucan branching enzyme activity

description: Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain.


name: hydrolase activity, hydrolyzing O-glycosyl compounds

description: Catalysis of the hydrolysis of any O-glycosyl bond.


name: 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)

description: Catalysis of the reaction: a glucosylated glycogenin = a glycogen.


name: FOLH1_HUMAN Glutamate carboxypeptidase 2 (sprot)

description: A glutamate carboxypeptidase 2 that is encoded in the genome of human.


Ac-Asp-Glu binding

description: Binding to Ac-Asp-Glu.


description: Binding to tetrahydrofolyl-poly(glutamate) polymer.


C-terminal protein deglutamylation

description: The removal of a C-terminal, gene-encoded glutamate residue from a protein.


name: IF4G1_HUMAN Eukaryotic translation initiation factor 4 gamma 1 (sprot)

description: A eukaryotic translation initiation factor 4 gamma 1 that is encoded in the genome of human.


name: positive regulation of eukaryotic translation initiation factor 4F complex assembly

description: Any process that activates or increases the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly.


positive regulation of mRNA cap binding

description: Any process that activates or increases the frequency, rate or extent of mRNA cap binding.


name: ATP7A_HUMAN Copper-transporting ATPase 1 (sprot)

description: A copper-transporting ATPase 1 that is encoded in the genome of human.


name: superoxide dismutase copper chaperone activity

description: A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity.


tryptophan metabolic process

description: The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.


peptidyl-lysine modification

description: The modification of peptidyl-lysine.


name: negative regulation of iron ion transmembrane transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore.


epinephrine metabolic process

description: The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.


elastin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of elastin, a fibrous glycoprotein found in elastic tissues such as the walls of arteries.


copper ion export

description: The directed movement of copper ions out of a cell or organelle.


name: positive regulation of response to wounding

description: Any process that activates or increases the frequency, rate or extent of response to wounding.


P_HUMAN P protein (sprot)

A P protein that is encoded in the genome of human.


lysosomal lumen pH elevation

description: Any process that increases the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.


name: K1C17_HUMAN Keratin, type I cytoskeletal 17 (sprot)

description: A keratin, type I cytoskeletal 17 that is encoded in the genome of human.


name: NOTC2_HUMAN Neurogenic locus notch homolog protein 2 (sprot)

description: A neurogenic locus notch homolog protein 2 that is encoded in the genome of human.


cholangiocyte proliferation

description: The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water.


regulation of osteoclast development

description: Any process that modulates the frequency, rate or extent of osteoclast development.


name: TLE1_HUMAN Transducin-like enhancer protein 1 (sprot)

description: A transducin-like enhancer protein 1 that is encoded in the genome of human.


name: TLE2_HUMAN Transducin-like enhancer protein 2 (sprot)

description: A transducin-like enhancer protein 2 that is encoded in the genome of human.


name: TLE3_HUMAN Transducin-like enhancer protein 3 (sprot)

description: A transducin-like enhancer protein 3 that is encoded in the genome of human.


name: TLE4_HUMAN Transducin-like enhancer protein 4 (sprot)

description: A transducin-like enhancer protein 4 that is encoded in the genome of human.


name: EMX1_HUMAN Homeobox protein EMX1 (sprot)

description: A homeobox protein EMX1 that is encoded in the genome of human.


name: EMX2_HUMAN Homeobox protein EMX2 (sprot)

description: A homeobox protein EMX2 that is encoded in the genome of human.


name: HGFA_HUMAN Hepatocyte growth factor activator (sprot)

description: A hepatocyte growth factor activator that is encoded in the genome of human.


name: KPCT_HUMAN Protein kinase C theta type (sprot)

description: A protein kinase C theta type that is encoded in the genome of human.


name: positive regulation of T-helper 2 cell activation

description: Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation.


name: LGUL_HUMAN Lactoylglutathione lyase (sprot)

description: A lactoylglutathione lyase that is encoded in the genome of human.


lactoylglutathione lyase activity

description: Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.


methylglyoxal metabolic process

description: The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.


name: ACVR1_HUMAN Activin receptor type-1 (sprot)

description: An activin receptor type-1 that is encoded in the genome of human.


name: endocardial cushion cell fate commitment

description: The commitment of a cell to an endocardial cushion cell fate and its capacity to differentiate into an endocardial cushion cell.


name: AK1C1_HUMAN Aldo-keto reductase family 1 member C1 (sprot)

description: An aldo-keto reductase family 1 member C1 that is encoded in the genome of human.


description: Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + H+ + NADPH.


name: steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative.


name: androsterone dehydrogenase (B-specific) activity

description: Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+.


name: SSBP_HUMAN Single-stranded DNA-binding protein, mitochondrial (sprot)

description: A single-stranded DNA-binding protein, mitochondrial that is encoded in the genome of human.


name: positive regulation of mitochondrial DNA replication

description: Any process that increases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion.


name: ACHE_HUMAN Acetylcholine receptor subunit epsilon (sprot)

description: An acetylcholine receptor subunit epsilon that is encoded in the genome of human.


REL_HUMAN Proto-oncogene c-Rel (sprot)

A proto-oncogene c-Rel that is encoded in the genome of human.


name: MUC24_HUMAN Sialomucin core protein 24 (sprot)

description: A sialomucin core protein 24 that is encoded in the genome of human.


name: RON_HUMAN Macrophage-stimulating protein receptor (sprot)

description: A macrophage-stimulating protein receptor that is encoded in the genome of human.


1433F_HUMAN 14-3-3 protein eta (sprot)

A 14-3-3 protein eta that is encoded in the genome of human.


glucocorticoid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.


name: PLP2_HUMAN Proteolipid protein 2 (sprot)

description: A proteolipid protein 2 that is encoded in the genome of human.


name: CSTF1_HUMAN Cleavage stimulation factor subunit 1 (sprot)

description: A cleavage stimulation factor subunit 1 that is encoded in the genome of human.


name: SRY_HUMAN Sex-determining region Y protein (sprot)

description: A sex-determining region Y protein that is encoded in the genome of human.


name: ICA69_HUMAN Islet cell autoantigen 1 (sprot)

description: An islet cell autoantigen 1 that is encoded in the genome of human.


name: UBE3A_HUMAN Ubiquitin-protein ligase E3A (sprot)

description: A ubiquitin-protein ligase E3A that is encoded in the genome of human.


sperm entry

description: An endocytosis process that results in penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur.


name: positive regulation of Golgi lumen acidification

description: Any process that activates or increases the frequency, rate or extent of Golgi lumen acidification.


DYN1_HUMAN Dynamin-1 (sprot)

A dynamin-1 that is encoded in the genome of human.


name: clathrin coat assembly involved in endocytosis

description: The process that results in the assembly of clathrin triskelia into a clathrin cage during endocytosis. Clathrin is recruited to the plasma membrane via interaction with scaffolding proteins that bridge between clathtin and cell surface receptors. Clathrin coat formation is concomittant with coated pit formation leading to endocytic vesicle formation.


name: MAD1_HUMAN Max dimerization protein 1 (sprot)

description: A max dimerization protein 1 that is encoded in the genome of human.


name: PTN12_HUMAN Tyrosine-protein phosphatase non-receptor type 12 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 12 that is encoded in the genome of human.


name: negative regulation of ERBB signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway.


name: EGR4_HUMAN Early growth response protein 4 (sprot)

description: An early growth response protein 4 that is encoded in the genome of human.


LEG10_HUMAN Galectin-10 (sprot)

A galectin-10 that is encoded in the genome of human.


name: DCE2_HUMAN Glutamate decarboxylase 2 (sprot)

description: A glutamate decarboxylase 2 that is encoded in the genome of human.


name: FAK1_HUMAN Focal adhesion kinase 1 (sprot)

description: A focal adhesion kinase 1 that is encoded in the genome of human.


name: LIPS_HUMAN Hormone-sensitive lipase (sprot)

description: A hormone-sensitive lipase that is encoded in the genome of human.


description: Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid.


description: Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid.


name: ZNF91_HUMAN Zinc finger protein 91 (sprot)

description: A zinc finger protein 91 that is encoded in the genome of human.


name: KPCZ_HUMAN Protein kinase C zeta type (sprot)

description: A protein kinase C zeta type that is encoded in the genome of human.


name: ZBT16_HUMAN Zinc finger and BTB domain-containing protein 16 (sprot)

description: A zinc finger and BTB domain-containing protein 16 that is encoded in the genome of human.


name: SRS11_HUMAN Serine/arginine-rich splicing factor 11 (sprot)

description: A serine/arginine-rich splicing factor 11 that is encoded in the genome of human.


name: NMDZ1_HUMAN Glutamate receptor ionotropic, NMDA 1 (sprot)

description: A glutamate receptor ionotropic, NMDA 1 that is encoded in the genome of human.


propylene metabolic process

description: The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals.


response to glycine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus.


name: EF1A2_HUMAN Elongation factor 1-alpha 2 (sprot)

description: An elongation factor 1-alpha 2 that is encoded in the genome of human.


name: KPCD_HUMAN Protein kinase C delta type (sprot)

description: A protein kinase C delta type that is encoded in the genome of human.


name: positive regulation of phospholipid scramblase activity

description: Any process that activates or increases the frequency, rate or extent of phospholipid scramblase activity.


name: regulation of ceramide biosynthetic process

description: Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process.


name: positive regulation of glucosylceramide catabolic process

description: Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process.


name: positive regulation of sphingomyelin catabolic process

description: Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic process.


CALD1_HUMAN Caldesmon (sprot)

A caldesmon that is encoded in the genome of human.


name: COEA1_HUMAN Collagen alpha-1(XIV) chain (sprot)

description: A collagen alpha-1(XIV) chain that is encoded in the genome of human.


name: regulation of cell growth involved in cardiac muscle cell development

description: Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.


collagen type XIV trimer

description: A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures.


name: RN5A_HUMAN 2-5A-dependent ribonuclease (sprot)

description: A 2-5A-dependent ribonuclease that is encoded in the genome of human.


name: ACHB3_HUMAN Neuronal acetylcholine receptor subunit beta-3 (sprot)

description: A neuronal acetylcholine receptor subunit beta-3 that is encoded in the genome of human.


name: DUS2_HUMAN Dual specificity protein phosphatase 2 (sprot)

description: A dual specificity protein phosphatase 2 that is encoded in the genome of human.


name: HME1_HUMAN Homeobox protein engrailed-1 (sprot)

description: A homeobox protein engrailed-1 that is encoded in the genome of human.


name: FOLC_HUMAN Folylpolyglutamate synthase, mitochondrial (sprot)

description: A folylpolyglutamate synthase, mitochondrial that is encoded in the genome of human.


description: Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).


description: The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues.


name: VMAT2_HUMAN Synaptic vesicular amine transporter (sprot)

description: A synaptic vesicular amine transporter that is encoded in the genome of human.


serotonin secretion by mast cell

description: The regulated release of serotonin by a mast cell or group of mast cells.


sequestering of neurotransmitter

description: The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system.


name: neurotransmitter loading into synaptic vesicle

description: The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps.


somato-dendritic dopamine secretion

description: The regulated release of dopamine from the somatodendritic compartment (cell body or dendrites) of a neuron.


name: STP2_HUMAN Nuclear transition protein 2 (sprot)

description: A nuclear transition protein 2 that is encoded in the genome of human.


name: ZP2_HUMAN Zona pellucida sperm-binding protein 2 (sprot)

description: A zona pellucida sperm-binding protein 2 that is encoded in the genome of human.


name: MBTD1_HUMAN MBT domain-containing protein 1 (sprot)

description: An MBT domain-containing protein 1 that is encoded in the genome of human.


name: NuA4 histone acetyltransferase complex binding

description: Binding to a NuA4 histone acetyltransferase complex.


name: EMAL5_HUMAN Echinoderm microtubule-associated protein-like 5 (sprot)

description: An echinoderm microtubule-associated protein-like 5 that is encoded in the genome of human.


name: CTSL2_HUMAN CTD small phosphatase-like protein 2 (sprot)

description: A CTD small phosphatase-like protein 2 that is encoded in the genome of human.


name: DEUP1_HUMAN Deuterosome assembly protein 1 (sprot)

description: A deuterosome assembly protein 1 that is encoded in the genome of human.


name: FHI1A_HUMAN FHF complex subunit HOOK-interacting protein 1A (sprot)

description: An FHF complex subunit HOOK-interacting protein 1A that is encoded in the genome of human.


name: protein localization to perinuclear region of cytoplasm

description: A process in which a protein is transported to, or maintained in, a location within the perinuclear region of the cytoplasm.


name: ITIH3_HUMAN Inter-alpha-trypsin inhibitor heavy chain H3 (sprot)

description: An inter-alpha-trypsin inhibitor heavy chain H3 that is encoded in the genome of human.


name: AT5G2_HUMAN ATP synthase F(0) complex subunit C2, mitochondrial (sprot)

description: An ATP synthase F(0) complex subunit C2, mitochondrial that is encoded in the genome of human.


name: PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 11 that is encoded in the genome of human.


microvillus organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.


name: negative regulation of cortisol secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell.


name: negative regulation of growth hormone secretion

description: Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell.


intestinal epithelial cell migration

description: The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism.


name: KDSR_HUMAN 3-ketodihydrosphingosine reductase (sprot)

description: A 3-ketodihydrosphingosine reductase that is encoded in the genome of human.


3-keto-sphinganine metabolic process

description: The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine.


3-dehydrosphinganine reductase activity

description: Catalysis of the reaction: NADP+ + sphinganine = 3-dehydrosphinganine + H+ + NADPH.


name: REG3A_HUMAN Regenerating islet-derived protein 3-alpha (sprot)

description: A regenerating islet-derived protein 3-alpha that is encoded in the genome of human.


name: BTK_HUMAN Tyrosine-protein kinase BTK (sprot)

description: A tyrosine-protein kinase BTK that is encoded in the genome of human.


name: positive regulation of type I hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response.


name: regulation of B cell cytokine production

description: Any process that modulates the frequency, rate, or extent of B cell cytokine production.


monocyte proliferation

description: The expansion of a monocyte population by cell division.


name: positive regulation of interleukin-17A production

description: Any process that activates or increases the frequency, rate or extent of interleukin-17A production.


name: P2R3A_HUMAN Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (sprot)

description: A serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha that is encoded in the genome of human.


An amidophosphoribosyltransferase that is encoded in the genome of human.


name: GFPT1_HUMAN Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (sprot)

description: A glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 that is encoded in the genome of human.


name: WIT1_HUMAN Putative Wilms tumor upstream neighbor 1 gene protein (sprot)

description: A Wilms tumor-associated protein that is encoded in the genome of human.


name: EXOS9_HUMAN Exosome complex component RRP45 (sprot)

description: An exosome complex component RRP45 that is encoded in the genome of human.


AOXA_HUMAN Aldehyde oxidase (sprot)

An aldehyde oxidase that is encoded in the genome of human.


name: PSME1_HUMAN Proteasome activator complex subunit 1 (sprot)

description: A proteasome activator complex subunit 1 that is encoded in the genome of human.


name: antigen processing and presentation of exogenous antigen

description: The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex.


name: SUH_HUMAN Recombining binding protein suppressor of hairless (sprot)

description: A recombining binding protein suppressor of hairless that is encoded in the genome of human.


name: regulation of generation of precursor metabolites and energy

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances.


name: arterial endothelial cell fate commitment

description: The commitment of a cell to an arterial endothelial cell fate and its capacity to differentiate into an arterial endothelial cell.


blood vessel lumenization

description: The process in which a developing blood vessel forms an endothelial lumen through which blood will flow.


name: blood vessel endothelial cell fate specification

description: The process involved in the specification of identity of a blood vessel endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. A blood vessel endothelial cell is an endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.


name: positive regulation of ERBB signaling pathway

description: Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway.


name: positive regulation of ephrin receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of ephrin receptor signaling pathway.


name: MEF2C_HUMAN Myocyte-specific enhancer factor 2C (sprot)

description: A myocyte-specific enhancer factor 2C that is encoded in the genome of human.


sinoatrial valve morphogenesis

description: The process in which the structure of the sinoatrial valve is generated and organized.


muscle cell fate determination

description: The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed.


cellular response to trichostatin A

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus.


name: P5F1B_HUMAN Putative POU domain, class 5, transcription factor 1B (sprot)


name: TYRO3_HUMAN Tyrosine-protein kinase receptor TYRO3 (sprot)

description: A tyrosine-protein kinase receptor TYRO3 that is encoded in the genome of human.


name: CCG1_HUMAN Voltage-dependent calcium channel gamma-1 subunit (sprot)

description: A voltage-dependent calcium channel gamma-1 subunit that is encoded in the genome of human.


MTG8_HUMAN Protein CBFA2T1 (sprot)

A protein CBFA2T1 that is encoded in the genome of human.


name: APLP2_HUMAN Amyloid beta precursor like protein 2 (sprot)

description: An amyloid beta precursor like protein 2 that is encoded in the genome of human.


name: NPT2A_HUMAN Sodium-dependent phosphate transport protein 2A (sprot)

description: A sodium-dependent phosphate transport protein 2A that is encoded in the genome of human.


indole metabolic process

description: The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).


gentamycin metabolic process

description: The chemical reactions and pathways involving gentamycin.


arsenate ion transmembrane transport

description: The process in which arsenate is transported across a membrane.


name: positive regulation of phosphate transmembrane transport

description: Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport.


name: ST2A1_HUMAN Sulfotransferase 2A1 (sprot)

description: A sulfotransferase 2A1 that is encoded in the genome of human.


alcohol sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.


bile-salt sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.


name: GABPA_HUMAN GA-binding protein alpha chain (sprot)

description: A GA-binding protein alpha chain that is encoded in the genome of human.


name: GABP1_HUMAN GA-binding protein subunit beta-1 (sprot)

description: A GA-binding protein subunit beta-1 that is encoded in the genome of human.


name: RING1_HUMAN E3 ubiquitin-protein ligase RING1 (sprot)

description: An E3 ubiquitin-protein ligase RING1 that is encoded in the genome of human.


name: RAD51_HUMAN DNA repair protein RAD51 homolog 1 (sprot)

description: A DNA repair protein RAD51 homolog 1 that is encoded in the genome of human.


DNA strand exchange activity

description: Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.


TNFC_HUMAN Lymphotoxin-beta (sprot)

A lymphotoxin-beta that is encoded in the genome of human.


name: PAX8_HUMAN Paired box protein Pax-8 (sprot)

description: A paired box protein Pax-8 that is encoded in the genome of human.


name: regulation of thyroid-stimulating hormone secretion

description: Any process that modulates the frequency, rate or extent of thyroid-stimulating hormone secretion.


name: ZN33A_HUMAN Zinc finger protein 33A (sprot)

description: A zinc finger protein 33A that is encoded in the genome of human.


name: ZN33B_HUMAN Zinc finger protein 33B (sprot)

description: A zinc finger protein 33B that is encoded in the genome of human.


name: FMR1_HUMAN Fragile X messenger ribonucleoprotein 1 (sprot)

description: A fragile X messenger ribonucleoprotein 1 that is encoded in the genome of human.


name: negative regulation of miRNA-mediated gene silencing

description: A process that decreases the rate, frequency, or extent of gene silencing by a microRNA (miRNA).


name: positive regulation of intracellular transport of viral material

description: Any process that activates or increases the frequency, rate or extent of intracellular transport of viral material.


name: negative regulation of cytoplasmic translation

description: Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation.


FMOD_HUMAN Fibromodulin (sprot)

A fibromodulin that is encoded in the genome of human.


PRDX1_HUMAN Peroxiredoxin-1 (sprot)

A peroxiredoxin-1 that is encoded in the genome of human.


name: EGR3_HUMAN Early growth response protein 3 (sprot)

description: An early growth response protein 3 that is encoded in the genome of human.


name: SOX4_HUMAN Transcription factor SOX-4 (sprot)

description: A transcription factor SOX-4 that is encoded in the genome of human.


name: positive regulation of N-terminal peptidyl-lysine acetylation

description: Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-lysine acetylation.


name: ACHD_HUMAN Acetylcholine receptor subunit delta (sprot)

description: An acetylcholine receptor subunit delta that is encoded in the genome of human.


name: CDK18_HUMAN Cyclin-dependent kinase 18 (sprot)

description: A cyclin-dependent kinase 18 that is encoded in the genome of human.


name: TNR9_HUMAN Tumor necrosis factor receptor superfamily member 9 (sprot)

description: A tumor necrosis factor receptor superfamily member 9 that is encoded in the genome of human.


name: regulation of immature T cell proliferation in thymus

description: Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus.


name: RL18_HUMAN Large ribosomal subunit protein eL18 (sprot)

description: A large ribosomal subunit protein eL18 that is encoded in the genome of human.


name: C1QBP_HUMAN Complement component 1 Q subcomponent-binding protein, mitochondrial (sprot)

description: A complement component 1 Q subcomponent-binding protein, mitochondrial that is encoded in the genome of human.


kininogen binding

description: Binding to a kininogen, a kinin precursor.


adrenergic receptor binding

description: Binding to an adrenergic receptor.


name: negative regulation of RIG-I signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the RIG-I signaling pathway.


name: CKAP4_HUMAN Cytoskeleton-associated protein 4 (sprot)

description: A cytoskeleton-associated protein 4 that is encoded in the genome of human.


name: AMPE_HUMAN Glutamyl aminopeptidase (sprot)

description: A glutamyl aminopeptidase that is encoded in the genome of human.


name: COGA1_HUMAN Collagen alpha-1(XVI) chain (sprot)

description: A collagen alpha-1(XVI) chain that is encoded in the genome of human.


collagen type XVI trimer

description: A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils.


name: CD69_HUMAN Early activation antigen CD69 (sprot)

description: A CD69 molecule that is encoded in the genome of human.


name: ZO1_HUMAN Tight junction protein ZO-1 (sprot)

description: A tight junction protein ZO-1 that is encoded in the genome of human.


adherens junction maintenance

description: The maintenance of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.


name: positive regulation of blood-brain barrier permeability

description: Any process that increases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain.


TRHY_HUMAN Trichohyalin (sprot)

A trichohyalin that is encoded in the genome of human.


name: CXCL9_HUMAN C-X-C motif chemokine 9 (sprot)

description: A C-X-C motif chemokine 9 that is encoded in the genome of human.


name: PIGF_HUMAN Phosphatidylinositol-glycan biosynthesis class F protein (sprot)

description: A phosphatidylinositol-glycan biosynthesis class F protein that is encoded in the genome of human.


ethanolaminephosphotransferase activity

description: Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine.


name: PDE4B_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4B (sprot)

description: A 3',5'-cyclic-AMP phosphodiesterase 4B that is encoded in the genome of human.


name: negative regulation of relaxation of cardiac muscle

description: Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of cardiac muscle.


name: TISB_HUMAN mRNA decay activator protein ZFP36L1 (sprot)

description: An mRNA decay activator protein ZFP36L1 that is encoded in the genome of human.


name: NKG2E_HUMAN NKG2-E type II integral membrane protein (sprot)

description: An NKG2-E type II integral membrane protein that is encoded in the genome of human.


DERM_HUMAN Dermatopontin (sprot)

A dermatopontin that is encoded in the genome of human.


name: BSPH1_HUMAN Binder of sperm protein homolog 1 (sprot)

description: A binder of sperm protein homolog 1 that is encoded in the genome of human.


name: SPAG1_HUMAN Sperm-associated antigen 1 (sprot)

description: A sperm-associated antigen 1 that is encoded in the genome of human.


axonemal dynein complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.


name: KRA11_HUMAN Keratin-associated protein 1-1 (sprot)

description: A keratin-associated protein 1-1 that is encoded in the genome of human.


TFF3_HUMAN Trefoil factor 3 (sprot)

A trefoil factor 3 that is encoded in the genome of human.


name: KHDR1_HUMAN KH domain-containing, RNA-binding, signal transduction-associated protein 1 (sprot)

description: A KH domain-containing, RNA-binding, signal transduction-associated protein 1 that is encoded in the genome of human.


regulation of RNA export from nucleus

description: Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm.


Grb2-Sos complex

description: A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.


name: DLX2_HUMAN Homeobox protein DLX-2 (sprot)

description: A homeobox protein DLX-2 that is encoded in the genome of human.


name: SCN1B_HUMAN Sodium channel subunit beta-1 (sprot)

description: A sodium channel subunit beta-1 that is encoded in the genome of human.


name: voltage-gated sodium channel activity involved in Purkinje myocyte action potential

description: Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


corticospinal neuron axon guidance

description: The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues.


name: membrane depolarization during Purkinje myocyte cell action potential

description: The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


name: positive regulation of voltage-gated sodium channel activity

description: Any process that activates or increases the frequency, rate or extent of voltage-gated sodium channel activity.


name: BAX_HUMAN Apoptosis regulator BAX (sprot)

description: An apoptosis regulator BAX that is encoded in the genome of human.


T cell homeostatic proliferation

description: The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.


B cell negative selection

description: Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion.


name: release of matrix enzymes from mitochondria

description: The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process.


name: positive regulation of developmental pigmentation

description: Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.


name: protein insertion into mitochondrial membrane

description: The process that results in the incorporation of a protein into a mitochondrial membrane.


name: B cell receptor apoptotic signaling pathway

description: An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell.


name: positive regulation of motor neuron apoptotic process

description: Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process.


BAX complex

description: An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators.


BAK complex

description: An oligomeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators.


name: B2CL1_HUMAN Bcl-2-like protein 1 (sprot)

description: A Bcl-2-like protein 1 that is encoded in the genome of human.


dendritic cell proliferation

description: The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.


apoptotic process in bone marrow cell

description: The apoptotic process in cells in the bone marrow.


name: MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (sprot)

description: An induced myeloid leukemia cell differentiation protein Mcl-1 that is encoded in the genome of human.


name: SLC31_HUMAN Amino acid transporter heavy chain SLC3A1 (sprot)

description: An amino acid transporter heavy chain SLC3A1 that is encoded in the genome of human.


basic amino acid transport

description: The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: DPOE1_HUMAN DNA polymerase epsilon catalytic subunit A (sprot)

description: A DNA polymerase epsilon catalytic subunit A that is encoded in the genome of human.


name: KLC1_HUMAN Kinesin light chain 1 (sprot)

description: A kinesin light chain 1 that is encoded in the genome of human.


name: PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (sprot)

description: A peroxisome proliferator-activated receptor alpha that is encoded in the genome of human.


name: positive regulation of transformation of host cell by virus

description: Any process that activates or increases the frequency, rate or extent of transformation of host cell by virus.


name: regulation of cellular ketone metabolic process

description: Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.


regulation of fatty acid transport

description: Any process that modulates the frequency, rate or extent of fatty acid transport.


name: SOS1_HUMAN Son of sevenless homolog 1 (sprot)

description: A son of sevenless homolog 1 that is encoded in the genome of human.


name: regulation of pro-B cell differentiation

description: Any process that modulates the frequency, rate or extent of pro-B cell differentiation.


name: SOS2_HUMAN Son of sevenless homolog 2 (sprot)

description: A son of sevenless homolog 2 that is encoded in the genome of human.


name: ACK1_HUMAN Activated CDC42 kinase 1 (sprot)

description: An activated CDC42 kinase 1 that is encoded in the genome of human.


name: LRP1_HUMAN Prolow-density lipoprotein receptor-related protein 1 (sprot)

description: A low-density lipoprotein receptor-related protein 1 that is encoded in the genome of human.


alpha-2 macroglobulin receptor activity

description: Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis.


apolipoprotein receptor activity

description: Combining with an apolipoprotein to initiate a change in cell activity.


regulation of phospholipase A2 activity

description: Any process that modulates the activity of the enzyme phospholipase A2.


name: SRSF1_HUMAN Serine/arginine-rich splicing factor 1 (sprot)

description: A splicing factor, arginine/serine-rich 1 that is encoded in the genome of human.


name: RHG01_HUMAN Rho GTPase-activating protein 1 (sprot)

description: A Rho GTPase-activating protein 1 that is encoded in the genome of human.


name: negative regulation of endocytic recycling

description: Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling.


name: CP24A_HUMAN 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (sprot)

description: A 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial that is encoded in the genome of human.


description: Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol.


name: 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity

description: Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol).


description: Catalysis of the reaction: calcidiol + 2 H+ + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin].


vitamin D 25-hydroxylase activity

description: Catalysis of the hydroxylation of C-25 of any form of vitamin D.


ACTN3_HUMAN Alpha-actinin-3 (sprot)

An alpha-actinin-3 that is encoded in the genome of human.


name: negative regulation of relaxation of muscle

description: Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of muscle.


name: positive regulation of glucose catabolic process to lactate via pyruvate

description: Any process that activates or increases the frequency, rate or extent of glucose catabolic process to lactate via pyruvate.


name: FOXM1_HUMAN Forkhead box protein M1 (sprot)

description: A forkhead box protein M1 that is encoded in the genome of human.


name: RGS1_HUMAN Regulator of G-protein signaling 1 (sprot)

description: A regulator of G-protein signaling 1 that is encoded in the genome of human.


leukotriene signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by leukotriene binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


TLE5_HUMAN TLE family member 5 (sprot)

A TLE family member 5 that is encoded in the genome of human.


name: SRSF4_HUMAN Serine/arginine-rich splicing factor 4 (sprot)

description: A serine/arginine-rich splicing factor 4 that is encoded in the genome of human.


PCDH1_HUMAN Protocadherin-1 (sprot)

A protocadherin-1 that is encoded in the genome of human.


name: TGM3_HUMAN Protein-glutamine gamma-glutamyltransferase E (sprot)

description: A protein-glutamine gamma-glutamyltransferase E that is encoded in the genome of human.


name: PP2BA_HUMAN Protein phosphatase 3 catalytic subunit alpha (sprot)

description: A protein phosphatase 3 catalytic subunit alpha that is encoded in the genome of human.


name: regulation of cell proliferation involved in kidney morphogenesis

description: Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney.


name: positive regulation of glomerulus development

description: Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.


name: negative regulation of angiotensin-activated signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the angiotensin-activated signaling pathway.


name: positive regulation of cardiac muscle hypertrophy in response to stress

description: Any process that activates or increases the frequency, rate or extent of cardiac muscle hypertrophy in response to stress.


name: DHX9_HUMAN ATP-dependent RNA helicase A (sprot)

description: An ATP-dependent RNA helicase A that is encoded in the genome of human.


regulatory region RNA binding

description: Binding to a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.


3'-5' DNA/RNA helicase activity

description: Unwinding of a DNA/RNA duplex in the 3' to 5' direction, driven by ATP hydrolysis.


triplex DNA binding

description: Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination.


name: single-stranded 3'-5' DNA helicase activity

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'.


DNA-templated viral transcription

description: A transcription process that uses a viral DNA as a template.


name: positive regulation of viral transcription

description: Any process that activates or increases the frequency, rate or extent of viral transcription.


regulation of cytoplasmic translation

description: Any process that modulates the frequency, rate or extent of cytoplasmic translation.


name: QOR_HUMAN Quinone oxidoreductase (sprot)

description: A quinone oxidoreductase that is encoded in the genome of human.


NADH binding

description: Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.


name: CACB2_HUMAN Voltage-dependent L-type calcium channel subunit beta-2 (sprot)

description: A voltage-dependent L-type calcium channel subunit beta-2 that is encoded in the genome of human.


name: membrane depolarization during atrial cardiac muscle cell action potential

description: The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


name: I10R2_HUMAN Interleukin-10 receptor subunit beta (sprot)

description: An interleukin-10 receptor subunit beta that is encoded in the genome of human.


interleukin-10 receptor activity

description: Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


interleukin-28 receptor complex

description: A protein complex that binds interleukin-28 and interleukin-29. It is composed of an alpha and a beta receptor subunit (in human IFNLR1/IL28Ralpha & IL10RB) and either Interleukin-28 (IFNL2 or IFNL3) or Interleukin-29 (IFNL1).


name: DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (sprot)

description: A discoidin domain-containing receptor 1 that is encoded in the genome of human.


name: protein tyrosine kinase collagen receptor activity

description: Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.


name: S20A2_HUMAN Sodium-dependent phosphate transporter 2 (sprot)

description: A sodium-dependent phosphate transporter 2 that is encoded in the genome of human.


name: GOGA3_HUMAN Golgin subfamily A member 3 (sprot)

description: A golgin subfamily A member 3 that is encoded in the genome of human.


name: GOGA2_HUMAN Golgin subfamily A member 2 (sprot)

description: A golgin subfamily A member 2 that is encoded in the genome of human.


meiotic spindle assembly

description: The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis.


Golgi cis cisterna

description: The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.


name: LG3BP_HUMAN Galectin-3-binding protein (sprot)

description: A galectin-3-binding protein that is encoded in the genome of human.


name: LOXL1_HUMAN Lysyl oxidase homolog 1 (sprot)

description: A lysyl oxidase homolog 1 that is encoded in the genome of human.


name: ECHP_HUMAN Peroxisomal bifunctional enzyme (sprot)

description: A peroxisomal bifunctional enzyme that is encoded in the genome of human.


description: Catalysis of the reaction: a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD+ = a long-chain 3-oxo-fatty acyl-CoA + H+ + NADH. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


MFGM_HUMAN Lactadherin (sprot)

A lactadherin that is encoded in the genome of human.


name: ADCY2_HUMAN Adenylate cyclase type 2 (sprot)

description: An adenylate cyclase type 2 that is encoded in the genome of human.


CP4F3_HUMAN Cytochrome P450 4F3 (sprot)

A cytochrome P450 4F3 that is encoded in the genome of human.


name: PDE4C_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4C (sprot)

description: A 3',5'-cyclic-AMP phosphodiesterase 4C that is encoded in the genome of human.


DEMA_HUMAN Dematin (sprot)

A dematin that is encoded in the genome of human.


name: PDE4D_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4D (sprot)

description: A 3',5'-cyclic-AMP phosphodiesterase 4D that is encoded in the genome of human.


signaling receptor regulator activity

description: Binds to and modulates the activity of a receptor.


DSC1_HUMAN Desmocollin-1 (sprot)

A desmocollin-1 that is encoded in the genome of human.


A pseudouridine-5'-phosphatase that is encoded in the genome of human.


pseudouridine 5'-phosphatase activity

description: Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate.


TICN1_HUMAN Testican-1 (sprot)

A testican-1 that is encoded in the genome of human.


name: SG11B_HUMAN Sperm-associated antigen 11B (sprot)

description: A sperm-associated antigen 11B that is encoded in the genome of human.


name: CLM6_HUMAN CMRF35-like molecule 6 (sprot)

description: A CMRF35-like molecule 6 that is encoded in the genome of human.


name: CD47_HUMAN Leukocyte surface antigen CD47 (sprot)

description: A CD47 molecule that is encoded in the genome of human.


name: PPID_HUMAN Peptidyl-prolyl cis-trans isomerase D (sprot)

description: A eukaryotic-type peptidyl-prolyl cis-trans isomerase D that is encoded in the genome of human.


name: ADCY1_HUMAN Adenylate cyclase type 1 (sprot)

description: An adenylate cyclase type 1 that is encoded in the genome of human.


name: FGL1_HUMAN Fibrinogen-like protein 1 (sprot)

description: A fibrinogen-like protein 1 that is encoded in the genome of human.


name: ITK_HUMAN Tyrosine-protein kinase ITK/TSK (sprot)

description: A tyrosine-protein kinase ITK/TSK that is encoded in the genome of human.


name: SSRP1_HUMAN FACT complex subunit SSRP1 (sprot)

description: A FACT complex subunit SSRP1 that is encoded in the genome of human.


FACT complex

description: A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage.


name: RBL2_HUMAN Retinoblastoma-like protein 2 (sprot)

description: A retinoblastoma-like protein 2 that is encoded in the genome of human.


name: CAMP2_HUMAN Calmodulin-regulated spectrin-associated protein 2 (sprot)

description: A calmodulin-regulated spectrin-associated protein 1-like protein 1 that is encoded in the genome of human.


regulation of organelle organization

description: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.


regulation of Golgi organization

description: Any process that modulates the frequency, rate or extent of Golgi organization.


name: SPIR1_HUMAN Protein spire homolog 1 (sprot)

description: A protein spire homolog 1 that is encoded in the genome of human.


formin-nucleated actin cable assembly

description: The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.


name: SLFN5_HUMAN Schlafen family member 5 (sprot)

description: A Schlafen family member 5 that is encoded in the genome of human.


name: ZN844_HUMAN Zinc finger protein 844 (sprot)

description: A zinc finger protein 844 that is encoded in the genome of human.


name: MZT1_HUMAN Mitotic-spindle organizing protein 1 (sprot)

description: A mitotic-spindle organizing protein 1 that is encoded in the genome of human.


gamma-tubulin complex localization

description: Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location.


name: ACSM1_HUMAN Acyl-coenzyme A synthetase ACSM1, mitochondrial (sprot)

description: An acyl-coenzyme A synthetase ACSM1, mitochondrial that is encoded in the genome of human.


CoA-ligase activity

description: Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.


benzoate-CoA ligase activity

description: Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.


benzoate metabolic process

description: The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid.


butyrate metabolic process

description: The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid.


name: ACS2A_HUMAN Acyl-coenzyme A synthetase ACSM2A, mitochondrial (sprot)

description: An acyl-coenzyme A synthetase ACSM2A, mitochondrial that is encoded in the genome of human.


name: S38AB_HUMAN Putative sodium-coupled neutral amino acid transporter 11 (sprot)

description: A putative sodium-coupled neutral amino acid transporter 11 that is encoded in the genome of human.


name: VAC14_HUMAN Protein VAC14 homolog (sprot)

description: A protein VAC14 that is encoded in the genome of human.


name: ZN616_HUMAN Zinc finger protein 616 (sprot)

description: A zinc finger protein 616 that is encoded in the genome of human.


F27E3_HUMAN Protein FAM27E3 (sprot)

A protein FAM27E3 that is encoded in the genome of human.


name: ZN543_HUMAN Zinc finger protein 543 (sprot)

description: A zinc finger protein 543 that is encoded in the genome of human.


name: SIG14_HUMAN Sialic acid-binding Ig-like lectin 14 (sprot)

description: A sialic acid-binding Ig-like lectin 14 that is encoded in the genome of human.


name: NSUN2_HUMAN RNA cytosine C(5)-methyltransferase NSUN2 (sprot)

description: An RNA cytosine C(5)-methyltransferase NSUN2 that is encoded in the genome of human.


description: Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H+ + S-adenosyl-L-homocysteine.


meiotic cell cycle checkpoint signaling

description: A signaling process that contributes to a meiotic cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage.


name: DMPK_HUMAN Myotonin-protein kinase (sprot)

description: A myotonin-protein kinase that is encoded in the genome of human.


myosin phosphatase regulator activity

description: Binds to and modulates of the activity of myosin phosphatase.


name: regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction

description: Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.


name: DMWD_HUMAN Dystrophia myotonica WD repeat-containing protein (sprot)

description: A dystrophia myotonica WD repeat-containing protein that is encoded in the genome of human.


name: RBBP4_HUMAN Histone-binding protein RBBP4 (sprot)

description: A histone-binding protein RBBP4 that is encoded in the genome of human.


CAF-1 complex

description: A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48.


name: NCBP1_HUMAN Nuclear cap-binding protein subunit 1 (sprot)

description: A nuclear cap-binding protein subunit 1 that is encoded in the genome of human.


positive regulation of RNA binding

description: Any process that activates or increases the frequency, rate or extent of RNA binding.


name: MGAT3_HUMAN Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (sprot)

description: A beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase that is encoded in the genome of human.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R.


name: MGT5A_HUMAN Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (sprot)

description: An alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A that is encoded in the genome of human.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors.


name: ABCC8_HUMAN ATP-binding cassette sub-family C member 8 (sprot)

description: An ATP-binding cassette sub-family C member 8 that is encoded in the genome of human.


name: negative regulation of neuroblast migration

description: Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration.


name: positive regulation of uterine smooth muscle relaxation

description: Any process that activates or increases the frequency, rate or extent of uterine smooth muscle relaxation.


name: KCNA1_HUMAN Potassium voltage-gated channel subfamily A member 1 (sprot)

description: A voltage-gated potassium channel subunit KCNA1 that is encoded in the genome of human.


name: detection of mechanical stimulus involved in sensory perception of touch

description: The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal.


name: EP300_HUMAN Histone acetyltransferase p300 (sprot)

description: A histone acetyltransferase p300 that is encoded in the genome of human.


name: lysine N-acetyltransferase activity, acting on acetyl phosphate as donor

description: Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.


peptide N-acetyltransferase activity

description: Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide.


name: histone H3K18 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18).


name: histone H3K27 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27).


description: Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide.


protein propionyltransferase activity

description: Catalysis of the reaction: propionyl-CoA + lysine in peptide = CoA + N-propionyl-lysine-peptide.


description: Catalysis of the reaction: 2-hydroxyisobutyryl-CoA + lysine in peptide = CoA + N-2-hydroxyisobutyryl-lysine-peptide.


name: histone lactyltransferase (CoA-dependent) activity

description: Catalysis of the reaction: (L-lysyl-[histone] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[histone].


peptide butyryltransferase activity

description: Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide.


histone crotonyltransferase activity

description: Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone.


histone butyryltransferase activity

description: Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone.


name: histone H3K122 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 122) = CoA + histone H3 N6-acetyl-L-lysine (position 122).


thigmotaxis

description: The directed movement of an animal in response to touch.


behavioral defense response

description: A behavioral response seeking to protect an organism from an a perceived external threat to that organism.


N-terminal peptidyl-lysine acetylation

description: The acetylation of the N-terminal lysine of proteins.


swimming

description: Self-propelled movement of an organism from one location to another through water, often by means of active fin movement.


peptidyl-lysine propionylation

description: The propionylation of peptidyl-lysine.


peptidyl-lysine crotonylation

description: The crotonylation of a lysine residue in a protein. Crotonyl is the univalent radical CH3-CH=CH-CO- derived from crotonic acid.


peptidyl-lysine butyrylation

description: The butyrylation of a lysine residue in a protein. Butyryl is the univalent radical C3H7COO- derived from butyric acid.


name: AHNK_HUMAN Neuroblast differentiation-associated protein AHNAK (sprot)

description: A neuroblast differentiation-associated protein AHNAK that is encoded in the genome of human.


name: structural molecule activity conferring elasticity

description: The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling.


name: ZN415_HUMAN Zinc finger protein 415 (sprot)

description: A zinc finger protein 415 that is encoded in the genome of human.


name: R51A2_HUMAN RAD51-associated protein 2 (sprot)

description: A RAD51-associated protein 2 that is encoded in the genome of human.


name: GOG8D_HUMAN Putative golgin subfamily A member 8D (sprot)


name: IFFO1_HUMAN Non-homologous end joining factor IFFO1 (sprot)

description: A non-homologous end joining factor IFFO1 that is encoded in the genome of human.


name: ZN763_HUMAN Zinc finger protein 763 (sprot)

description: A zinc finger protein 763 that is encoded in the genome of human.


name: NIPA4_HUMAN Magnesium transporter NIPA4 (sprot)

description: A magnesium transporter NIPA4 that is encoded in the genome of human.


name: magnesium ion transmembrane transporter activity

description: Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.


magnesium ion transmembrane transport

description: The directed movement of magnesium ion across a membrane.


RIPP1_HUMAN Protein ripply1 (sprot)

A protein ripply1 that is encoded in the genome of human.


name: EGFEM_HUMAN Putative EGF-like and EMI domain-containing protein 1 (sprot)


name: NTCP7_HUMAN Sodium/bile acid cotransporter 7 (sprot)

description: A sodium/bile acid cotransporter 7 that is encoded in the genome of human.


name: TBC8B_HUMAN TBC1 domain family member 8B (sprot)

description: A TBC1 domain family member 8B that is encoded in the genome of human.


name: FCHO2_HUMAN F-BAR domain only protein 2 (sprot)

description: An F-BAR domain only protein 2 that is encoded in the genome of human.


name: ARL16_HUMAN ADP-ribosylation factor-like protein 16 (sprot)

description: An ADP-ribosylation factor-like protein 16 that is encoded in the genome of human.


name: CQ067_HUMAN Uncharacterized protein C17orf67 (sprot)

description: An uncharacterized protein C17orf67 that is encoded in the genome of human.


ABD18_HUMAN Protein ABHD18 (sprot)

A protein ABHD18 that is encoded in the genome of human.


name: SPEM2_HUMAN Uncharacterized protein SPEM2 (sprot)

description: An uncharacterized protein SPEM2 that is encoded in the genome of human.


name: DIK1C_HUMAN Divergent protein kinase domain 1C (sprot)

description: A divergent protein kinase domain 1C that is encoded in the genome of human.


name: CCD15_HUMAN Coiled-coil domain-containing protein 15 (sprot)

description: A coiled-coil domain-containing protein 15 that is encoded in the genome of human.


name: TMM62_HUMAN Transmembrane protein 62 (sprot)

description: A transmembrane protein 62 that is encoded in the genome of human.


name: ELP6_HUMAN Elongator complex protein 6 (sprot)

description: An elongator complex protein 6 that is encoded in the genome of human.


name: PLCX2_HUMAN PI-PLC X domain-containing protein 2 (sprot)

description: A PI-PLC X domain-containing protein 2 that is encoded in the genome of human.


SYCN_HUMAN Syncollin (sprot)

A syncollin that is encoded in the genome of human.


LMOD3_HUMAN Leiomodin-3 (sprot)

A leiomodin-3 that is encoded in the genome of human.


name: RGF1B_HUMAN Ras-GEF domain-containing family member 1B (sprot)

description: A Ras-GEF domain-containing family member 1B that is encoded in the genome of human.


name: SMAGP_HUMAN Small cell adhesion glycoprotein (sprot)

description: A small transmembrane and glycosylated protein that is encoded in the genome of human.


name: APOBR_HUMAN Apolipoprotein B receptor (sprot)

description: An apolipoprotein B receptor that is encoded in the genome of human.


INCA1_HUMAN Protein INCA1 (sprot)

A protein INCA1 that is encoded in the genome of human.


name: BRME1_HUMAN Break repair meiotic recombinase recruitment factor 1 (sprot)

description: A break repair meiotic recombinase recruitment factor 1 that is encoded in the genome of human.


name: DYH14_HUMAN Dynein axonemal heavy chain 14 (sprot)

description: A dynein axonemal heavy chain 14 that is encoded in the genome of human.


ADIG_HUMAN Adipogenin (sprot)

An adipogenin that is encoded in the genome of human.


name: HSP7E_HUMAN Heat shock 70 kDa protein 14 (sprot)

description: A heat shock 70 kDa protein 14 that is encoded in the genome of human.


name: 'de novo' cotranslational protein folding

description: The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated.


SCRN3_HUMAN Secernin-3 (sprot)

A secernin-3 that is encoded in the genome of human.


cysteine-type exopeptidase activity

description: Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


name: TM267_HUMAN Transmembrane protein 267 (sprot)

description: A transmembrane protein 267 that is encoded in the genome of human.


name: CGNL1_HUMAN Cingulin-like protein 1 (sprot)

description: A cingulin-like protein 1 that is encoded in the genome of human.


name: CF210_HUMAN Cilia- and flagella- associated protein 210 (sprot)

description: A cilia- and flagella- associated protein 210 that is encoded in the genome of human.


name: FP100_HUMAN Fanconi anemia core complex-associated protein 100 (sprot)

description: A Fanconi anemia core complex-associated protein 100 that is encoded in the genome of human.


name: YC023_HUMAN Putative uncharacterized protein LOC152225 (sprot)


name: MESP2_HUMAN Mesoderm posterior protein 2 (sprot)

description: A mesoderm posterior protein 2 that is encoded in the genome of human.


name: ZN816_HUMAN Zinc finger protein 816 (sprot)

description: A zinc finger protein 816 that is encoded in the genome of human.


name: LTOR4_HUMAN Ragulator complex protein LAMTOR4 (sprot)

description: A ragulator complex protein LAMTOR4 that is encoded in the genome of human.


name: U17LO_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 24 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 17-like protein 24 that is encoded in the genome of human.


name: protein deubiquitination involved in ubiquitin-dependent protein catabolic process

description: The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism.


name: FABP9_HUMAN Fatty acid-binding protein 9 (sprot)

description: A fatty acid-binding protein 9 that is encoded in the genome of human.


NEXN_HUMAN Nexilin (sprot)

A nexilin that is encoded in the genome of human.


PJVK_HUMAN Pejvakin (sprot)

A pejvakin that is encoded in the genome of human.


name: programmed cell death in response to reactive oxygen species

description: Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.


name: MGAT2_HUMAN Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (sprot)

description: An alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase that is encoded in the genome of human.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R.


name: GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (sprot)

description: A polypeptide N-acetylgalactosaminyltransferase 2 that is encoded in the genome of human.


description: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.


name: protein O-linked glycosylation via serine

description: The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine.


name: protein O-linked glycosylation via threonine

description: The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine.


name: GALT1_HUMAN Polypeptide N-acetylgalactosaminyltransferase 1 (sprot)

description: A polypeptide N-acetylgalactosaminyltransferase 1 that is encoded in the genome of human.


name: AP1B1_HUMAN AP-1 complex subunit beta-1 (sprot)

description: An AP-1 complex subunit beta-1 that is encoded in the genome of human.


name: CPSF1_HUMAN Cleavage and polyadenylation specificity factor subunit 1 (sprot)

description: A cleavage and polyadenylation specificity factor subunit 1 that is encoded in the genome of human.


name: co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway

description: Any process involved in transcription termination-coupled 3' processing of RNA polymerase II RNA transcripts by 3' end cleavage and addition of a poly(A) tail.


name: MN1_HUMAN Transcriptional activator MN1 (sprot)

description: A transcriptional activator MN1 that is encoded in the genome of human.


name: DBP_HUMAN D site-binding protein (sprot)

description: A D site-binding protein that is encoded in the genome of human.


name: TEF_HUMAN Thyrotroph embryonic factor (sprot)

description: A thyrotroph embryonic factor that is encoded in the genome of human.


name: BST1_HUMAN ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (sprot)

description: An ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 that is encoded in the genome of human.


regulation of cellular extravasation

description: Any process that modulates the frequency, rate, or extent of cellular extravasation.


name: regulation of superoxide metabolic process

description: Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.


name: BST2_HUMAN Bone marrow stromal antigen 2 (sprot)

description: A bone marrow stromal antigen 2 that is encoded in the genome of human.


name: negative regulation of plasmacytoid dendritic cell cytokine production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.


name: negative regulation of intracellular transport of viral material

description: Any process that stops, prevents or reduces the frequency, rate or extent of intracellular transport of viral material.


name: MPPA_HUMAN Mitochondrial-processing peptidase subunit alpha (sprot)

description: A mitochondrial-processing peptidase subunit alpha that is encoded in the genome of human.


name: KRIP1_HUMAN Putative protein KRIP1 (sprot)

description: A putative protein KRIP1 that is encoded in the genome of human.


name: FUT2_HUMAN Galactoside alpha-(1,2)-fucosyltransferase 2 (sprot)

description: A galactoside alpha-(1,2)-fucosyltransferase 2 that is encoded in the genome of human.