activated SUMO-E1 ligase complex

description: A protein complex consisting of a SUMO protein bound to a SUMO activating enzyme complex. Activation by the E1 complex and linkage to the E2 enzyme UBE2I is required for the formation of covalent bonds between SUMO and its ultimate target proteins.


polymeric IgA immunoglobulin complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein complex composed of two, three, or four monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.


description: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane.


SC5b-7 complex

description: A protein complex that consist of complement components C5b6 and C7 stably inserted in a cell membrane. Formation of the SC5b-7 complex is the first phase of membrane attack complex assembly.


telomere-telomerase complex

description: A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome.


name: RNA polymerase V transcription regulator complex

description: A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase V.


name: RNA polymerase III transcription repressor complex

description: A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase III promoter.


NPHP complex

description: A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways.


carbamoyl-phosphate synthase complex

description: A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events.


Dxr protein complex

description: A protein complex that is involved in the MEP pathway of IPP biosynthesis. It catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).


SCF-Met30/Pof1 ubiquitin ligase complex

description: An SCF ubiquitin ligase complex in which the F-box protein is Met30 in S. cerevisiae (Pof1 in S pombe).


CENP-A recruiting complex

description: A protein complex that includes Mis16(Yippee family) and/or Mis18 (WD repeat) subunits that is involved in the deposition of centromere specific (CENP-A containing) nucleosomes at the centromere.


alphav-beta3 integrin-ADAM23 complex

description: A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM23.


alpha4-beta1 integrin-CD47 complex

description: A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell surface antigen CD47.


name: mitochondrial glutamate synthase complex (NADH)

description: A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity.


SCF-Mdm30 ubiquitin ligase complex

description: An SCF ubiquitin ligase complex in which the F-box protein is Mdm30 in S. cerevisiae.


name: mitochondrial respiratory chain complex I, membrane segment

description: The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix.


alpha3-beta1 integrin-CD63 complex

description: A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63.


description: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane.


protein-lipid-RNA complex

description: A macromolecular complex containing separate protein, lipid and RNA molecules. Separate in this context means not covalently bound to each other.


SOD1-calcineurin complex

description: A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1.


hyphal tip polarisome

description: Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha.


COMA complex

description: A kinetochore multiprotein complex that bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly. In yeast, consists of Ctf19p, Okp1p, Mcm21p, and Ame1p.


name: PSI associated light-harvesting complex I

description: Protein-pigment complex associated with photosystem I.


monopolin complex

description: A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits.


platelet SNARE complex

description: A SNARE complex that is capable of fusing intracellular vesicles to the plasma membrane of platelets for exocytosis of alpha-granules or dense granules. Contains isoforms of VAMP, SNAP and syntaxin proteins. Ternary SNARE complexes interact in a circular array to form ring complexes or channels around the membrane fusion. A common composition in human is VAMP-8, SNAP-23 and syntaxin-2 or -4.


eisosome filament

description: A filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1.


alphaIIb-beta3 integrin-CIB complex

description: A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin.


DnaA-DiaA complex

description: A protein-DNA complex containing a tetramer of DiaA attached to multiple DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA.


name: cytosolic proteasome core complex, beta-subunit complex

description: The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex.


Rpd3L complex

description: A histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a two copies of catalytic histone deacetylase subunit (S. pombe Clr6/ S. cerevisiae Rpd3p), an Sds-3 family protein (S. pombe /S. cerevisiae Sds3(p) ), two copies of SIN3 family co-repressor (S. pombe Pst1/ S. cerevisiae Sin3p, a WD repeat protein/ histone chaperone (S. pombe Prw1/ S. cerevisiae Ume1p), and a zf- PHD finger ( S. pombe Png2/ S. cerevisiae Pho23p), plus 4 additional subunits, and associated factors.


alphaX-beta2 integrin-ICAM-4 complex

description: A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4.


name: amyloplast ADPG pyrophosphorylase complex

description: An ADPG pyrophosphorylase complex found in the amyloplast.


name: alphaV-beta3 integrin-laminin alpha-4 complex

description: A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4.


auxin efflux carrier complex

description: The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell.


HICS complex

description: A multisubunit complex involved in cytokinesis. In the yeast Saccharomyces cerevisiae this complex consists of Sho1p, Hof1p, Inn1p and Cyk3p proteins.


description: A protein complex capable of catalysing the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.


glutamate synthase complex (NADPH)

description: A complex that possesses glutamate synthase (NADPH) activity.


ERBB4-ERBB3 complex

description: A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission.


3-phenylpropionate dioxygenase complex

description: Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol).


RGS6-DNMT1-DMAP1 complex

description: A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1.


Bre1-Rad6 ubiquitin ligase complex

description: A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis.


name: IgD immunoglobulin complex, GPI-anchored

description: A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and bound via a GPI-anchor to the plasma membrane of B cells.


name: potassium:proton antiporter complex

description: A protein complex which is capable of potassium:proton antiporter activity.


DnaB-DnaC-DnaT-PriA-PriB complex

description: A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriB, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired.


MAML2-RBP-Jkappa-ICN2 complex

description: A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.


name: endoplasmic reticulum palmitoyltransferase complex

description: A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue.


description: A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies.


ubiquitin activating enzyme complex

description: A protein complex responsible for the catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.


alpha9-beta1 integrin-VEGF-C complex

description: A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C.


description: A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Rab3a (or orthologs thereof).


IgD immunoglobulin complex, circulating

description: A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.


RITS complex

description: A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing.


RC-1 DNA recombination complex

description: A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA.


name: NAD(P)H dehydrogenase complex (plastoquinone)

description: Complex that possesses NAD(P)H dehydrogenase (plastoquinone) activity. The complex is one of the components of the electron transport chain. It is involved in electron transport from an unidentified electron donor, possibly NADH, NADPH or ferredoxin(Fd) to the plastoquinone pool.


serotonin receptor complex

description: A protein complex that is capable of serotonin receptor activity.


box C/D pre-rRNA cleavage RNP complex

description: A ribonucleoprotein complex containing a box C/D type RNA that is involved in pre-rRNA cleavage.


PYM-mago-Y14 complex

description: Protein complex involved in the disassembly of Mago-Y14 from the spliced mRNA during first round of translation, independently of the translational machinery. Conserved from fission yeast to humans.


phosphomannomutase complex

description: A protein complex capable of phosphomannomutase activity.


Ku-DNA ligase complex

description: A nonhomologous end joining complex that contains one or more Ku monomers and one or more DNA ligase molecules from the LigC or LigD family, and mediates nonhomologous end joining in bacteria.


alpha2-beta1 integrin-CD47 complex

description: A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47.


mating projection tip polarisome

description: Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone.


myosin X complex

description: A myosin complex containing one or more class X myosin heavy chains and associated light chains.


name: CSL-Notch-Mastermind transcription factor complex

description: A DNA-binding transcription factor complex consisting of CSL and mastermind proteins in complex with the cleaved, intracellular domain of Notch. It is required for both repression and activation of Notch target genes.


alpha6-beta4 integrin-laminin 5 complex

description: A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5.


name: RNA polymerase IV transcription repressor complex

description: A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase IV promoter.


hemozoin formation complex

description: A protein-containing complex involved in hemoglobin degradation and detoxification of heme in the food vacuole during the asexual blood stage of a Plasmodium. It is composed of at least falcipains FP2A and/or FP2B, plasmepsins PMII, PMIII/HAP and PMIV, heme detoxifying protein HDP and falcilysin FLN.


methanol-CoM methyltransferase complex

description: A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol.


beta-galactosidase complex

description: A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species.


interphase SIN signaling complex

description: A SIN signaling complex associated with the old mitotic spindle pole body during interphase and early M-phase and characterised by the presence active ubiquitin ligase (Dma1 in fission yeast) and GTPase activator (Spg1 in fission yeast) to inactivate SIN signaling.


description: A heterodimer which catalyses the reaction of 5-amino-6-(D-ribitylamino)uracil and 4-hydroxyphenylpyruvate to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), an intermediate of coenzyme F420.


Nrd1 complex

description: A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p.


ATPase inhibitor complex

description: A protein complex which is capable of ATPase inhibitor activity.


name: proton-transporting two-sector ATPase complex, proton-transporting domain

description: A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins.


name: fatty acid beta-oxidation multienzyme complex

description: A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT).


lateral cortical node

description: A protein complex that is anchored at the cortical face of the plasma membrane, and contains proteins involved in regulating cell cycle progression. In Schizosaccharomyces pombe, lateral cortical nodes are several megadaltons in size, and contain Slf1, which anchors the complex at the membrane, and the methyltransferase Skb1 in stoichiometric quantities, and may contain other proteins.


network-forming collagen trimer

description: A collagen trimer that forms networks.


2-iminoacetate synthase complex

description: A protein complex which is capable of 2-iminoacetate synthase activity.


collagen type XXI trimer

description: A collagen homotrimer of alpha1(XXI) chains; type XXI collagen triple helices found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle.


laminin-15 complex

description: A laminin complex composed of alpha5, beta2 and gamma3 polypeptide chains.


alpha4-beta1 integrin-CD63 complex

description: A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family.


nitrate reductase complex

description: An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor.


protein tyrosine phosphatase complex

description: A protein complex which is capable of protein tyrosine phosphatase activity.


name: mitochondrial electron transfer flavoprotein complex

description: A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system.


name: mitochondrial respiratory chain complex IV pre-assembly complex

description: A protein complex that contributes to and regulates mitochondrial respiratory chain complex IV (COX) formation. It acts by regulating mitochondrial COX1 translation and by promoting the assembly of COX components.


sulfite reductase complex (NADPH)

description: A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide.


nodal receptor complex

description: A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell.


SCF-Ufo1/Pof10 ubiquitin ligase complex

description: An SCF ubiquitin ligase complex in which the F-box protein is Ufo1 in S. cerevisiae (Pof10 in S. pombe).


integrin alphaE-beta7 complex

description: An integrin complex that comprises one alphaE subunit and one beta7 subunit.


description: A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK.


name: Wpl/Pds5 cohesin loading/unloading complex

description: A eukaryotically conserved heterodimeric protein complex (comprising Wings apart-like protein and the Pds5 Armadillo repeat cohesin associated protein) involved in the loading and unloading of a cohesin complex onto DNA.


name: X chromosome located dosage compensation complex, transcription activating

description: An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster.


ATP-independent citrate lyase complex

description: Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity. This enzyme has only been found in bacteria.


channel complex

description: A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.


name: histamine-gated chloride channel complex

description: A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts.


FtsBL complex

description: A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB and FtsL.


acetate CoA-transferase complex

description: A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA.


Grb2-Shc complex

description: A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway.


alphaV-beta3 integrin-EGFR complex

description: A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor.


PUMA-BCL-xl complex

description: A heterodimeric protein complex consisting of PUMA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.


mannan polymerase I complex

description: A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the priming and elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p and Van1p.


glutamate synthase complex (NADH)

description: A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity.


GroEL-GroES complex

description: Bacterial chaperonin complex consisting of a heptameric 10kDa chaperonin subunit GroES and a tetradecameric (2x7) 60kDa chaperonin subunit GroEL. The 60kDa subunit possesses ATPase activity while the holo-enzyme is responsible for the correct folding of proteins.


CD19-Vav-PIK3R1 complex

description: A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K).


nuclear replisome

description: A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.


TOR complex

description: A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K.


cellubrevin-VAMP4-syntaxin-16 complex

description: A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof).


description: A protein complex that possesses ferredoxin-thioredoxin reductase activity.


nuclear membrane protein complex

description: Any protein complex that is part of the nuclear membrane.


radial spoke 1

description: The radial spoke of each group of radial spokes, whether grouped as triplets or doublets, that is most proximal to the base of the cilium. Radial spoke 1 (RS1), similarly to radial spoke 2, is comprised of four domains: 1) a very short base anchored to the A microtubule, 2) an elongaged stalk, 3) a bifurcated neck, and 4) an orthogonal head. The base of RS1 is connected to the tail of the inner dynein arm a/d.


G-protein beta/gamma-Btk complex

description: A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein.


alpha9-beta1 integrin-ADAM3 complex

description: A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM3.


APC-IQGAP1-Cdc42 complex

description: A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration.


thioglucosidase complex

description: A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds.


name: large ribosomal subunit pre-assembly complex

description: A protein complex that assists early maturation of nascent 60S ribosomal subunits. The complex interacts with the large ribosomal subunit rRNA via one of the components (Urb2 in S. cerevisiae) and requires a RNA helicase (Dbp6 in S. cerevisiae).


formate dehydrogenase complex

description: An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2).


dimethyl sulfoxide reductase complex

description: An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide.


name: alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex

description: A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib.


description: A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof).


name: mitochondrial respiratory chain complex I, peripheral segment

description: The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix.


outer membrane protein complex

description: Any protein complex that is part of the bacterial outer membrane. An example In E.coli, is RcsF associated with any one of several outer membrane beta-barrel proteins (OMPs), such as OmpA, OmpF, or OmpcC.


name: high molecular weight kininogen receptor complex

description: A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins.


alpha4-beta1 integrin-CD53 complex

description: A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family.


ribosomal subunit

description: Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit.


alpha-heterochromatin

description: A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization.


description: A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src.


protein histidine kinase complex

description: A complex that possesses protein histidine kinase activity.


description: A SNARE complex that contains endobrevin (VAMP8), synaptobrevin 2 (VAMP2), alpha-SNAP, NSF, and syntaxin 4 (or orthologs thereof).


taste receptor complex

description: A protein complex which is capable of taste receptor activity.


name: proton-transporting ATP synthase, catalytic core

description: The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase.


chloroplast photosystem II

description: An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone.


description: A protein complex which is capable of protein-cysteine S-palmitoyltransferase activity.


myosin XIV complex

description: A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails.


name: alpha7-beta1 integrin-nicotinamide riboside kinase complex

description: A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP).


name: pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex

description: Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity.


type II polyketide synthase complex

description: A polyketide synthase complex that consists of several different polypeptide chains, each of which catalyzes a single reaction.


bI3 intron splicing complex

description: Aprotein complex required for the splicing of intron 3 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI3 (which derives from one of the products of the splicing), the MRS1 cofactor and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing.


U4atac/U6atac x U5 tri-snRNP complex

description: A spliceosomal snRNP complex that is formed by the association of the U4atac/U6atac and U5 snRNPs.


nucleocytoplasmic transport complex

description: Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores.


name: plasma membrane proton-transporting ATP synthase complex, coupling factor F(o)

description: All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins.


name: ATP-binding cassette (ABC) transporter complex, transmembrane substrate-binding subunit-containing

description: A complex for the transport of metabolites into the cell, consisting of 4 subunits: a transmembrane substrate-binding protein (known as the S component), and an energy-coupling module that comprises two ATP-binding proteins (known as the A and A' components) and a transmembrane protein (known as the T component). Transport of the substrate across the membrane is driven by the hydrolysis of ATP.


name: tripartite ATP-independent periplasmic transporter complex

description: A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients.


vacuolar transporter chaperone complex

description: A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p.


nuclear proteasome core complex

description: The core complex of a proteasome located in the nucleus of a cell.


myosin IV complex

description: A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV.


BID-BCL-2 complex

description: A heterodimeric protein complex consisting of BID and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.


name: cytosolic proteasome regulatory particle, base subcomplex

description: The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell.


name: lysosomal proton-transporting V-type ATPase, V1 domain

description: The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane.


SeqA-DNA complex

description: A protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle.


CUGBP1-eIF2 complex

description: A protein complex that contains the eukaryotic translation initiation factor 2 complex (EIF2), CUG binding protein 1, and several endoplasmic reticulum proteins; the complex is involved in the regulation of translation.


UBR1-RAD6 ubiquitin ligase complex

description: A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes.


name: alpha1-beta1 integrin-tissue transglutaminase complex

description: A protein complex that consists of an alpha1-beta1 integrin complex bound to tissue transglutaminase.


lymphotoxin complex

description: A homo- or heterotrimeric protein containing complex consisting of alpha and beta lymphotoxin subunits in different stoichiometric combinations.


vacuolar HOPS complex

description: Any HOPS complex that is part of a vacuolar membrane.


plastid acetate CoA-transferase complex

description: An acetate CoA-transferase complex located in the stroma of a plastid.


RSP5-BUL ubiquitin ligase complex

description: A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation.


exodeoxyribonuclease VII complex

description: An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA.


DnaA-Hda complex

description: A protein complex that inactivates the function of DnaA by inhibiting the phosphorylation of DnaA-ADP to DnaA-ATP and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of DnaA and Hda.


GCH1 complex

description: A protein complex that possesses GTP cyclohydrolase I activity. In E. coli and human, the complex is a homodecamer, and monomers are catalytically inactive.


cytoplasmic replisome

description: A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins.


DnaA-L2 complex

description: A protein complex that inhibits unwinding of DNA at the origin of replication and assembly of the pre-primosome. In E. coli, this complex is composed of DnaA and of the ribosomal protein L2.


isocitrate dehydrogenase complex (NAD+)

description: Complex that possesses isocitrate dehydrogenase (NAD+) activity.


ModE complex

description: A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism.


Slit-Robo signaling complex

description: A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate.


alkanesulfonate monooxygenase complex

description: A protein complex capable of alkanesulfonate monooxygenase activity. Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation, catalyzing the conversion of alkanesulfonates into aldehydes and sulfite. In E.coli the complex consists of a SsuD tetramer.


description: A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1).


name: nuclear proteasome core complex, alpha-subunit complex

description: The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell.


plastid ADPG pyrophosphorylase complex

description: An ADPG pyrophosphorylase complex found in a plastid.


nuclear membrane complex Bqt3-Bqt4

description: A protein complex that resides in the inner nuclear membrane and anchors telomeres to the nuclear envelope. In fission yeast, it is composed of Bqt3 and Bqt4.


APC-IQGAP complex

description: A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration.


TAT protein transport complex

description: A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins.


multivesicular body HOPS complex

description: Any HOPS complex that is part of a multivesicular body membrane.


DnaB helicase complex

description: A homohexameric protein complex that possesses DNA helicase activity; functions during DNA replication and repair.


name: superoxide dismutase copper chaperone complex

description: A protein complex which is capable of superoxide dismutase copper chaperone activity.


name: signal recognition particle, chloroplast targeting

description: A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to the chloroplast.


IgE immunoglobulin complex, circulating

description: A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.


tRNA-guanine transglycosylase complex

description: A protein complex that catalyzes the base-exchange of a guanine residue with queuine at the wobble position of the anticodon of tRNAs. The eukaryotic tRNA-guanine transglycosylase exists as a heterodimer of a catalytic subunit (QTRT1 in humans) and an accessory subunit (QTRT2 in humans), whereas the bacterial enzyme is homodimeric.


B875 antenna complex

description: Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm.


organellar large ribosomal subunit

description: The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).


Mcs4 RR-MAPKKK complex

description: A protein complex that consists of a phospho relay component and a MAPK cascade component. The complex is involved in signaling oxidative stress and osmostress.


glycoprotein complex

description: A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds.


name: cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex

description: A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.


alpha4-beta4 integrin-EMILIN-1 complex

description: A protein complex that consists of an alpha4-beta4 integrin complex bound to EMILIN-1 (ElastinMicrofibril Interface Located ProteIN).


alpha7-beta1 integrin-CD151 complex

description: A protein complex that consists of an alpha7-beta1 integrin complex bound to the tetraspanin CD151.


CoA-synthesizing protein complex

description: A multisubunit complex likely involved in the synthesis of coenzyme A (CoA). In S. cerevisiae, the complex consists of at least Cab2, Cab3, Cab4 and Cab5 but may also include Sis2 and Vhs3. The latter subunits are shared by the GO:0071513 phosphopantothenoylcysteine decarboxylase complex that catalyses the third step of the coenzyme A (CoA) biosynthetic pathway.


alkyl hydroperoxide reductase complex

description: An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides.


name: interferon regulatory factor 3-interferon regulatory factor 7 complex

description: An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 7.


name: plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex

description: A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate.


alphaIIb-beta3 integrin-CD9 complex

description: A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface protein CD9.


name: phosphatidylinositol 3-kinase complex, class II

description: A phosphatidylinositol 3-kinase complex that contains a catalytic subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme and one or more adaptor proteins. There is no known obligatory regulatory subunit. The class II PI3K (PI3KC2) subfamily of genes has members in vertebrates, worm and fly, but none in yeast.


actomyosin, myosin complex part

description: The myosin part of any complex of actin, myosin, and accessory proteins.


name: M/G1 phase-specific MADS box-forkhead transcription factor complex

description: A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2.


photosystem I

description: A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation).


chloroplastic endopeptidase Clp complex

description: A Clp endopeptidase complex located in the chloroplast.


transmembrane collagen trimer

description: Any collagen trimer that passes through a lipid bilayer membrane.


pyruvate kinase complex

description: A protein complex which is capable of pyruvate kinase activity.


description: A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2.


penta-snRNP complex

description: A ribonucleoprotein complex that is formed by the association of the U1, U2, U4/U6 and U5 small nuclear ribonucleoproteins.


name: trimethylamine-N-oxide reductase (cytochrome c) complex

description: A protein complex which is capable of trimethylamine-N-oxide reductase (cytochrome c) activity.


SKA complex

description: An outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis. In humans, it contains the subunits SKA1, SKA2 and SKA3.


efflux pump complex

description: A protein complex that is capable of efflux transmembrane transporter activity.


ESCRT complex

description: An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes.


DnaA-HU complex

description: A protein-DNA complex containing DNA-bound DnaA attached to HU. HU is a dimer encoded by two closely related genes. Essential for the initiation of replication in bacteria; stimulates the DnaA-dependent unwinding of oriC.


GATA1-TAL1-TCF3-Lmo2 complex

description: A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis.


interleukin-9 receptor complex

description: A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins.


ciliary necklace

description: A protein complex located on the cilium membrane in the ciliary transition zone; it is connected to the cilium axoneme via Y-shaped links.


BRCA2-BRAF35 complex

description: A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis.


i-AAA complex

description: Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases.


name: plasma membrane proton-transporting ATP synthase, central stalk

description: One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. Examples of this component are found in Bacterial species.


name: core TFIIH complex portion of NEF3 complex

description: The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3).


TOC-TIC supercomplex I

description: The protein transport macromolecular complex of the chloroplast membrane that interacts with the precursor proteins and contains components of both the outer membrane and inner membrane complexes containing at least Toc75, Toc159, Toc34 and Tic110.


description: A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-1.


description: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane.


name: RNA polymerase I transcription repressor complex

description: A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase I promoter.


RENT complex

description: A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit.


atf1-pcr1 complex

description: A heterodimeric transcription factor complex composed of the bZIP proteins atf1 and pcr1. The heterodimer binds m26 sites (homologous to CRE).


glutaminase complex

description: A protein complex which is capable of glutaminase activity.


name: ribulose bisphosphate carboxylase complex

description: A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate.


steroid hormone aporeceptor complex

description: A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand.


methyl coenzyme M reductase complex

description: A hexameric complex consisting of three polypeptides in an alpha2beta2gamma2 arrangement. Involved in the reduction of the coenzyme M-bound methyl group to methane, which is the final step in methanogenesis.


anchoring collagen complex

description: Any collagen complex which links one collagen assembly, such as a collagen fibril or sheet, to other structures.


magnesium chelatase complex

description: A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner.


Tea1 cell-end complex

description: A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity.


ciliary centrin arm

description: A rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules.


interferon regulatory factor 5 complex

description: An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 5.


IgG immunoglobulin complex, circulating

description: A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.


name: mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex

description: A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. An example of this component is found in Mus musculus.


IgM immunoglobulin complex, circulating

description: A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph.


SIN/MEN signaling complex

description: A protein complex associated with the mitotic spindle pole body during interphase and mitosis and comprises of the proteins of the septation initiation signaling network (SIN) of fission yeast or mitotic exit network (MEN) of budding yeast, organized by two scaffold/adaptor proteins.


name: single-stranded DNA-binding protein complex

description: A homotetrameric protein complex that is essential for DNA replication. It supercoils the single-stranded DNA preventing DNA duplexing before the polymerase holoenzyme passes and synthesizes the complementary strand. It is also involved in DNA recombination and repair.


IscS-TusA complex

description: A heterotetrameric protein complex involved in the sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm5s2U) at tRNA wobble positions. In E. coli it consists of a central IscS dimer with the two TusA protomers bound to one of the IscS units each via persulfide (-SSH) groups.


bI4 intron splicing complex

description: A protein complex required for the splicing of intron 4 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI4 (which derives from one of the products of the splicing), Leucyl-tRNA synthetase NAM2 and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing.


name: nucleotide-excision repair, preincision complex

description: A multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage.


name: pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex

description: Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity.


name: magnesium-dependent protein serine/threonine phosphatase complex

description: An intracellular enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase.


alphav-beta3 integrin-ADAM15 complex

description: A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM15.


transnitrosylase complex

description: A transferase complex which is capable of transferring nitrogenous groups from one component to another.


CD20-Lck-Lyn-Fyn complex

description: A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck, Lyn and Fyn.


name: ammonium transmembrane transporter complex

description: High affinity ammonium transporter complex that enables the transfer of ammonium from one side of a membrane to the other.


name: copper ion transmembrane transporter complex

description: A protein complex which is capable of copper ion transmembrane transporter activity.


name: PSII associated light-harvesting complex II, peripheral complex

description: Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light.


name: dihydropyrimidine dehydrogenase (NAD+) complex

description: A heteromultimeric complex capable of dihydropyrimidine dehydrogenase (NAD+); in E. coli, composed of PreA and PreT.


DnaB-DnaC complex

description: A protein complex containing homohexameric DNA helicase DnaB, and the DNA helicase loader DnaC. The helicase loader DnaC delivers DnaB to the chromosomal origin (oriC).


Lsd1/2 complex

description: A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast.


alpha6-beta1 integrin-CD151 complex

description: A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151.


name: Ras guanyl-nucleotide exchange factor complex

description: A protein complex which is capable of Ras guanyl-nucleotide exchange factor activity.


Y-shaped link

description: A Y-shaped protein complex in the ciliary transition zone that connects the cilium axoneme to the ciliary necklace. Both protein sorting and protein gating occur at this point in the cilium allowing some, but not all proteins to enter the cilium.


photosystem II reaction center

description: An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone.


photosystem II oxygen evolving complex

description: A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ).


amyloid-beta complex

description: Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease.


ribonuclease III complex

description: A protein complex which is capable of ribonuclease III activity.


name: homodimeric serine palmitoyltransferase complex

description: A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine.


description: A protein-lipid-RNA complex containing separate low-density lipoprotein (LDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other.


Myo2p-Vac17p-Vac8p transport complex

description: A protein complex that is involved in transport of vacuoles to a newly formed daughter cell. In yeast, this complex is composed of Myo2p, Vac17p, and Vac8p.


name: new spindle pole body SIN signaling complex

description: A SIN signaling complex associated with the new mitotic spindle pole body during anaphase and characterized by the presence activated (GTP bound) GTPase (Spg1 in fission yeast) to activate SIN signaling.


radial spoke neck

description: The radial spoke neck is a complex that connects the spoke stalk to the head.


counting factor complex

description: A secreted multiprotein complex composed of 4 proteins, regulating group size during aggregation in cooperative development. An example of this complex is found in Dictyostelium discoideum.


IgY immunoglobulin complex

description: A protein complex composed of two identical immunoglobulin heavy chains of the IgY isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgY immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.


description: A protein complex capable of catalyzing the transfer of a phosphate group from one position to another within a single molecule.


thiazole synthase complex

description: A protein complex which is capable of thiazole synthase activity.


MAML2-RBP-Jkappa-ICN3 complex

description: A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.


xanthine dehydrogenase complex

description: A homodimeric protein complex having xanthine dehydrogenase activity.


GDP-mannose pyrophosphorylase complex

description: A protein complex capable of catalyzing the reaction of GTP and mannose-1-phosphate to form GDP-mannose. The complex is a homodimer in most bacteria and a heterodimer in most eukaryotes. In humans, it is composed of a catalytic beta subunit (GMPPB) and a regulatory alpha subunit (GMPPA).


name: RNA polymerase IV transcription regulator complex

description: A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase IV.


EGFR-Shc-Grb2-Sos complex

description: A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2, the adaptor protein SHC and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.


name: nucleotide-excision repair factor 4 complex

description: One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p.


myosin III complex

description: A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain.


SOD1-Bcl-2 complex

description: A heterodimeric protein complex formed of superoxide dismutase 1 and Bcl-2. Complex formation is thought to link superoxide dismutase to an apoptotic pathway.


iron-iron nitrogenase complex

description: An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen.


gamma-secretase-Delta1 complex

description: A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex.


name: calcium:proton antiporter complex

description: A protein complex that enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in).


ERBB4-ERBB4 complex

description: A homodimeric complex containing two monomers of the tyrosine kinase receptor ERBB4 (also called HER4).


synapsis initiation complex

description: A SUMO-E3 ligase complex capable of promoting synapsis, the meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase.


DnaB-DnaG complex

description: A protein complex containing homohexameric DnaB helicase, and DnaG (a primase). Facilitates the unwinding of double-stranded DNA and the synthesis of RNA primer sequences during DNA replication and repair in Prokaryotes.


SCF-Pof5 ubiquitin ligase complex

description: An SCF ubiquitin ligase complex in which the F-box protein is Pof5 in S. pombe (YDR306C in S. cerevisiae).


collagen type XXIII trimer

description: A collagen homotrimer of alpha1(XXIII) chains; type XXIII collagen triple helices span the plasma membrane.


alpha6-beta1 integrin-CYR61 complex

description: A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis.


heterochromatin domain

description: A region of heterochromatin that is formed dynamically under specific growth conditions by a process that requires RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me).


description: A SNARE complex that contains VAMP4, syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof).


Cul8-RING ubiquitin ligase complex

description: A ubiquitin ligase complex in which a cullin from the Cul8 subfamily and a RING domain protein form the catalytic core. In S. cerevisiae, Mms1p acts as the adaptor protein and substrate specificity is conferred by any of a number of different proteins.


thylakoid light-harvesting complex

description: A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. An example of this is found in Arabidopsis thaliana.


tRNA (m2G10) methyltransferase complex

description: A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p.


glycine reductase complex

description: Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C.


cyanelle ribonuclease P complex

description: A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.


oxoadipate dehydrogenase complex

description: A multi-enzyme complex that catalyzes the oxidative decarboxylation of 2-oxoadipate to glutaryl-CoA, thereby acting in the final step of lysine and tryptophan catabolism in mitochondria. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: 2-oxoadipate dehydrogenase (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3).


urease complex

description: A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide).


iNOS-S100A8/A9 complex

description: A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine.


Ddb1-Ckn1 complex

description: A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases.


description: A protein complex which is capable of phosphatidylinositol transporter activity.


name: nuclear proteasome core complex, beta-subunit complex

description: The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell.


description: A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin.


histone H3-containing nucleosome

description: A complex comprised of DNA wound around a multisubunit core and associated proteins containing the histone H3, which forms the primary packing unit of DNA into higher order structures.


ERBB4:ERBB2 complex

description: A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4.


myosin I complex

description: A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement.


chloroplast ATP synthase complex

description: The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts.


integrin alphaD-beta2 complex

description: An integrin complex that comprises one alphaD subunit and one beta2 subunit.


SCF-Dia2/Pof3 ubiquitin ligase complex

description: An SCF ubiquitin ligase complex in which the F-box protein is Dia2 in S. cerevisiae (Pof3 in S. pombe).


Ddb1-Wdr21 complex

description: A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases.


SBF transcription complex

description: A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi4p and the activator Swi6p, and is associated with additional proteins known as Whi5p and Msa1p.


alpha9-beta1 integrin-ADAM1 complex

description: A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM1.


oligosaccharyltransferase II complex

description: An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma. Of the three forms of mammalian OST complexes identified, the OSTII complex has intermediate affinity for ribosomes.


alphaV-beta3 integrin-CD98 complex

description: A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98.


Hda-beta clamp complex

description: A protein complex involved in inactivating the function of DnaA and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of the beta clamp (DnaN) and Hda.


m7G(5')pppN diphosphatase complex

description: A homodimeric protein complex that catalyzes the reaction: 7-methylguanosine-5'-triphospho-5'-pholynucleotide + H20 = 7-methylguanosine-5'-phosphate + polynucleotide.


PKM2 protein kinase complex

description: A protein complex capable of phosphorylating a large number of protein targets. Contributes to cell proliferation under glycose starvation conditions. In human, the complex is present as a dimer.


description: A protein complex that consists of an alpha9-beta1 integrin complex bound to thrombospondin-1.


luminal surveillance complex

description: A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins.


endosomal scaffold complex

description: A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling.


pre-primosome complex

description: Any of the protein-DNA complexes that contain a DNA helicase and associated protein(s) at the origin of replication, and build up to assembling the core primosome. The associated protein(s) chaperone the helicase to the DNA, and assembly of the pre-primosome is essential for the initiation or restart of replication. Pre-primosome complexes lack a primase component.


myosin XVII complex

description: A myosin complex containing one or more class XVII myosin heavy chains and associated light chains.


DnaB-DnaC-Rep-PriC complex

description: A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins Rep and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired.


name: plasma membrane proton-transporting ATP synthase complex, catalytic core F(1)

description: The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. Examples of this component are found in Bacterial species.


neurotransmitter receptor complex

description: Any protein complex that is capable of functioning as a neurotransmitter receptor.


laminin-4 complex

description: A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains.


description: An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system.


BRCA1-Rad51 complex

description: A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity.


name: chloroplast thylakoid membrane protein complex

description: A protein complex that is part of a chloroplast thylakoid membrane.


Lid2 complex

description: A protein complex involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid2, Ash2, Jmj3, Snt2, and Sdc1.


DnaA-Dps complex

description: A protein complex that negatively regulates strand-opening at the origin of replication, thereby interfering with replication initiation. This complex is thought to be involved in the regulation of replication under oxidative stress conditions. In E. coli, this complex is composed of DnaA and Dps.


name: NADH dehydrogenase complex (plastoquinone)

description: An NADH dehydrogenase complex that catalyzes the transfer of electrons to plastoquinone. The complex is involved in the non-photochemical reduction of plastoquinones and the cyclic electron transport around photosystem I, and is found in plastid thylakoids.


alpha9-beta1 integrin-VEGF-A complex

description: A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A.


axonemal nexin link

description: A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules.


myosin XV complex

description: A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII.


description: A protein complex which is capable of pyrroline-5-carboxylate reductase activity.


chaperonin ATPase complex

description: Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts.


myosin XI complex

description: A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions.


alpha5-beta5-fibronectin-SFRP2 complex

description: A protein complex that consists of an alpha5-beta5 integrin complex bound to fibronectin and secreted frizzled-related protein 2.


name: PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex

description: A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides.


APC-IQGAP1-Rac1 complex

description: A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration.


Pi Mi complex

description: A transcription factor complex composed of a homeodomain protein and the M-specific peptide Mi that acts at the regulatory region of genes required for the activation of meiosis.


name: chaperone-mediated autophagy translocation complex

description: A lysosomal membrane protein complex that enables the translocation of a target protein across the lysosomal membrane as part of chaperone-mediated autophagy.


name: mitochondrial proton-transporting ATP synthase, central stalk

description: One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis.


name: Kelch-containing formin regulatory complex

description: A protein complex that regulates actin cable formation, polarized cell growth, and cytokinesis in a formin-dependent manner. In S. cerevisiae the complex is composed of Bud14p and two Kelch family proteins, Kel1p and Kel2p.


hydroxyisourate hydrolase complex

description: A hydrolase complex that converts 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline. This is the second step of the three-step enzymatic reaction that degrades uric acid to (S)-allantoin.


INA complex

description: A protein complex located in the inner membrane of mitochondria that is involved in the assembly of the peripheral (or stator) stalk of the mitochondrial proton-transporting ATP synthase (also known as the F1F0 ATP synthase). In budding yeast, this complex includes Ina22p and Ina17p.


type I protein secretion system complex

description: A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space.


name: heterotetrameric ADPG pyrophosphorylase complex

description: A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus.


name: type II protein secretion system complex

description: A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex.


name: tricarboxylic acid cycle heteromeric enzyme complex

description: Any of the heteromeric enzymes that act in the TCA cycle.


3-isopropylmalate dehydratase complex

description: A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.


name: sodium ion-transporting two-sector ATPase complex

description: A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis.


glideosome

description: A protein complex composed of at least GAP45 (gliding-associated protein), GAP50 and myosin heavy and light chains. Anchored via GAP50 to the inner membrane complex of motile and invasive forms of apicomplexan parasites and regulates parasite gliding motility and invasion of host cells.


HDA1 complex

description: A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p.


mitochondrial mRNA editing complex

description: An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates.


name: axonemal heterotrimeric kinesin-II complex

description: A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme.


basement membrane collagen trimer

description: Any collagen timer that is part of a basement membrane.


inhibin complex

description: Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B.


DASH complex

description: A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the outer kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability.


RAD6-UBR2 ubiquitin ligase complex

description: A ubiquitin ligase complex consisting of RAD6 and UBR2 components. It may act in a quality control pathway for proteins synthesized on cytosolic ribosomes. The UBR2 component lacks sequence motifs required for N-end rule degradation.


FHL3-CREB complex

description: A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation.


name: chromatophore ribulose bisphosphate carboxylase complex

description: A complex, located in the chromatophore, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate.


collagen type XX trimer

description: A collagen homotrimer of alpha1(XX) chains.


name: classical-complement-pathway C3/C5 convertase complex

description: A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone.


starch utilization system complex

description: A bacterial cell envelope-associated multiprotein system, which binds and degrades starch.


name: methyl accepting chemotaxis protein complex

description: A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus.


name: transcription-coupled nucleotide-excision repair, DNA damage recognition complex

description: A protein complex that is capable of identifying lesions in DNA on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex.


transcription factor TFIIIC1 complex

description: A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity.


name: transforming growth factor beta activated kinase 1 complex

description: A protein complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunits).


name: nuclear proteasome regulatory particle, base subcomplex

description: The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell.


Vps55/Vps68 complex

description: A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins.


DPS complex

description: A protein serine/threonine phosphatase complex that in S. pombe consists of the proteins Dis2, Ppn1, and Swd22.


PUMA-BCL-2 complex

description: A heterodimeric protein complex consisting of PUMA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.


Lsm-containing SMN-Sm protein complex

description: An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA.


name: PSI associated light-harvesting complex I, LHCIa subcomplex

description: A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm.


laminin-522 complex

description: A laminin complex composed of alpha5, beta2 and gamma2 polypeptide chains.


DiaA complex

description: A homotetrameric protein complex consisting of a symmetrical pair of DiaA homodimers. Facilitates DnaA binding to the origin of replication during replication initiation.


trans-synaptic protein complex

description: A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes.


exomer complex

description: A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues.


cobalamin transport complex

description: Protein complex facilitating ATP-dependent cobalamin (vitamin B12) transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic cobalamin-binding protein (BtuF), an integral membrane homodimer, BtuC, and a cytoplasmic ATP-binding homodimer BtuD.


MAML3-RBP-Jkappa-ICN4 complex

description: A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling.


name: methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex

description: A protein complex consisted of eight polypeptides. This complex catalyzes the formation of methyl-coenzyme M and H4MPT from N5-methyl-H4MPT and CoM during methanogenesis.


name: methionyl glutamyl tRNA synthetase complex

description: A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers.


glutamate-tRNA ligase complex

description: An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu).


radial spoke base

description: The short portion of the radial spoke that is directly anchored to the A microtubule of an axonemal microtubule doublet.


interleukin-4 receptor complex

description: A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor.


iron-sulfur cluster transfer complex

description: A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor), which may be a target protein or another Fe-S assembly complex. In humans, it consists of HSPA9, HSCB, GLRX5, ABCB7 and GFER.


photosystem I reaction center

description: A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin.


fatty-acyl-CoA synthase complex

description: A protein complex that possesses fatty-acyl-CoA synthase activity.


B800-850 antenna complex

description: Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex.


exoribonuclease complex

description: A protein complex which is capable of exoribonuclease activity.


glycine-tRNA ligase complex

description: A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly).


fumarate reductase complex

description: A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)).


Pip2-Oaf1 complex

description: A heterodimeric complex consisting of Zn(2)Cys(6) containing transcription factors Pip2 and Oaf1. It binds to the oleate response element (ORE), found in the promoters of fatty acid-inducible genes in Saccharomyces where, in the presence of oleate this bound complex activates the transcription of genes encoding peroxisomal proteins.


RasGAP-Fyn-Lyn-Yes complex

description: A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation.


description: A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin.


E.F.G complex

description: A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex.


nuclear pore linkers

description: A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p).


APC-IQGAP1-CLIP-170 complex

description: A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration.


name: type IV site-specific deoxyribonuclease complex

description: A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation.


heavy chain immunoglobulin complex

description: A protein complex composed of two identical immunoglobulin heavy chains of the IgNAR isotype held together by disulfide bonds and lacking immunoglobulin light chains.


name: alpha5-beta1 integrin-tissue transglutaminase complex

description: A protein complex that consists of an alpha5-beta1 integrin complex bound to tissue transglutaminase.


alpha6-beta4 integrin-CD151 complex

description: A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151.


IgD B cell receptor complex

description: An IgD immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.


replication inhibiting complex

description: A protein complex that inhibits multiple events of replication initiation during one replication cycle.


polyketide synthase complex

description: A protein complex that carries out enzymatic reactions involved in the biosynthesis of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones.


Grb2-SHP-2 complex

description: A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway.


CFTR-NHERF-ezrin complex

description: A protein complex that contains ezrin, Na+/H+ exchanger regulatory factor (NHERF, also called EBP50), and two copies of the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR molecules interact with NHERF via their cytoplasmic tail domains; the complex is thought to link the CFTR channel to the actin cytoskeleton and contribute to the regulation of channel activity.


CSK-GAP-A.p62 complex

description: A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation.


cortical Lewy body

description: Cytoplasmic inclusion similar to a classical Lewy body but lacking a halo of protein fibrils.


nucleolar peripheral inclusion body

description: Inclusion bodies located at the nucleolar periphery where several nuclear factors are reversibly aggregated and sequestered during acute heat stress or starvation.


nematosome

description: Cytoplasmic, ball-like inclusion resembling a nucleolus and consisting of a convoluted network of electron-opaque strands embedded in a less dense matrix. It measures approximately 0.9 microns and lacks a limiting membrane. Its strands (diameter = 400-600 A) appear to be made of an entanglement of tightly packed filaments and particles approximately 25-50 A thick. Cytochemical studies suggest the presence of nonhistone proteins and some RNA. Usually only one such structure is present in a cell, and it appears to occur in most ganglion cells. Although they can be seen anywhere in the cell body, nematosomes are typically located in the perinuclear cytoplasm, where they are often associated with smooth-surfaced and coated vesicles.


skein-like inclusion

description: Intracytoplasmic filamentous structure frequently encountered in preparations immunostained for ubiquitin.


fibrillary inclusion

description: Cellular inclusion consisting of circular areas filled with fine slender filaments about 10 nanometers in diameter, delimited by a wall of varying complexity (either a single continuous membrane or a tubular network consisting of a fine filamentous material giving the wall a honeycomb appearance). Fibrillary inclusions are found in the cytoplasm of giant cells of Dieters in the lateral vestibular nucleus of the rat; similar structures have been described in the ventral cochlear nucleus, spinal cord, and substantia nigra.


complex laminated body

description: A cytoplasmic inclusion body found in some lateral geniculate neurons and composed of sheets of tubules (25 nm in diameter) separated by dense material (about 75 nm wide), which together with the tubules whorl give a structure resembling a fingerprint.


laminated body

description: Inclusion body characterized by regularly spaced sheets of tubules arranged in a whorl pattern resembling a fingerprint. Laminated bodies have been observed in neurons of the lateral geniculate nucleus.


Pick body

description: Cellular inclusion composed of numerous tau fibrils arranged in a disorderly array. Tau protein is a major component, though Pick bodies also contain ubiquitin, alpha-synuclein, and apolipoprotein E.


hyaline inclusion

description: A glass-like, pale intracellular inclusion.


cnida

description: A giant secretory organelle that comprises a bulb-shape capsule containing a coiled hollow tubule structure attached to it. A cnida defines the phylum Cnidaria.


name: central plaque of mitotic spindle pole body

description: One of three laminate structures that form the mitotic spindle pole body; the inner plaque is on the nuclear face of the spindle pole body.