somatostatin signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by somatostatin binding to a somatostatin receptor (SSTR), and ending with the regulation of a downstream cellular process, e.g. transcription.


name: SSR2_HUMAN Somatostatin receptor type 2 (sprot)

description: A somatostatin receptor type 2 that is encoded in the genome of human.


name: RPB2_HUMAN DNA-directed RNA polymerase II subunit RPB2 (sprot)

description: A DNA-directed RNA polymerase II subunit RPB2 that is encoded in the genome of human.


RNA polymerase II activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


ribonucleoside binding

description: Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.


name: ACHB4_HUMAN Neuronal acetylcholine receptor subunit beta-4 (sprot)

description: A neuronal acetylcholine receptor subunit beta-4 that is encoded in the genome of human.


name: 5HT1F_HUMAN 5-hydroxytryptamine receptor 1F (sprot)

description: A 5-hydroxytryptamine receptor 1F that is encoded in the genome of human.


name: OR1E1_HUMAN Olfactory receptor 1E1 (sprot)

description: An olfactory receptor 1E1 that is encoded in the genome of human.


name: O10J1_HUMAN Olfactory receptor 10J1 (sprot)

description: An olfactory receptor 10J1 that is encoded in the genome of human.


name: GNRHR_HUMAN Gonadotropin-releasing hormone receptor (sprot)

description: A gonadotropin-releasing hormone I receptor that is encoded in the genome of human.


gonadotropin secretion

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone.


CALCR_HUMAN Calcitonin receptor (sprot)

A calcitonin receptor that is encoded in the genome of human.


calcitonin binding

description: Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid.


amylin receptor complex 1

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 1. Amylin receptor complex 1 (AMY1) also serves as a receptor for the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM).


amylin receptor complex 2

description: A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 2. Amylin receptor complex 2 (AMY2) also serves as a receptor for adrenomedullin (AM/ADM).


name: NTR1_HUMAN Neurotensin receptor type 1 (sprot)

description: A neurotensin receptor type 1 that is encoded in the genome of human.


name: G protein-coupled neurotensin receptor activity

description: Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.


regulation of membrane depolarization

description: Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.


inositol phosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.


name: NEUT_HUMAN Neurotensin/neuromedin N (sprot)

description: A neurotensin/neuromedin N that is encoded in the genome of human.


LCN1_HUMAN Lipocalin-1 (sprot)

A lipocalin-1 that is encoded in the genome of human.


name: SDHA_HUMAN Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sprot)

description: A succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial that is encoded in the genome of human.


succinate dehydrogenase activity

description: Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor.


succinate metabolic process

description: The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle.


COR1A_HUMAN Coronin-1A (sprot)

A coronin-1A that is encoded in the genome of human.


phagolysosome assembly

description: The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.


uropod organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated.


negative regulation of actin nucleation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.


thymocyte migration

description: The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development.


name: GDIA_HUMAN Rab GDP dissociation inhibitor alpha (sprot)

description: A Rab GDP dissociation inhibitor alpha that is encoded in the genome of human.


Rab GDP-dissociation inhibitor activity

description: Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding.


S10A7_HUMAN Protein S100-A7 (sprot)

A protein S100-A7 that is encoded in the genome of human.


zinc ion sequestering activity

description: Binding to a zinc ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.


name: positive regulation of granulocyte chemotaxis

description: Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.


name: MK04_HUMAN Mitogen-activated protein kinase 4 (sprot)

description: A mitogen-activated protein kinase 4 that is encoded in the genome of human.


name: METK2_HUMAN S-adenosylmethionine synthase isoform type-2 (sprot)

description: An S-adenosylmethionine synthetase isoform type-2 that is encoded in the genome of human.


methionine adenosyltransferase activity

description: Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.


description: The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.


cellular response to methionine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus.


methionine adenosyltransferase complex

description: A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules.


name: S5A2_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (sprot)

description: A 3-oxo-5-alpha-steroid 4-dehydrogenase 2 that is encoded in the genome of human.


name: HXD3_HUMAN Homeobox protein Hox-D3 (sprot)

description: A homeobox protein Hox-D3 that is encoded in the genome of human.


name: HXA10_HUMAN Homeobox protein Hox-A10 (sprot)

description: A homeobox protein Hox-A10 that is encoded in the genome of human.


name: HXA6_HUMAN Homeobox protein Hox-A6 (sprot)

description: A homeobox protein Hox-A6 that is encoded in the genome of human.


name: HXA7_HUMAN Homeobox protein Hox-A7 (sprot)

description: A homeobox protein Hox-A7 that is encoded in the genome of human.


name: HXA9_HUMAN Homeobox protein Hox-A9 (sprot)

description: A homeobox protein Hox-A9 that is encoded in the genome of human.


name: HXA11_HUMAN Homeobox protein Hox-A11 (sprot)

description: A homeobox protein Hox-A11 that is encoded in the genome of human.


positive regulation of cell development

description: Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.


name: positive regulation of chondrocyte development

description: Any process that activates or increases the frequency, rate or extent of chondrocyte development.


name: HXA13_HUMAN Homeobox protein Hox-A13 (sprot)

description: A homeobox protein Hox-A13 that is encoded in the genome of human.


embryonic hindgut morphogenesis

description: The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase.


endothelial cell fate specification

description: The process involved in the specification of identity of an endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.


mitotic nuclear division

description: A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.


name: HXC8_HUMAN Homeobox protein Hox-C8 (sprot)

description: A homeobox protein Hox-C8 that is encoded in the genome of human.


name: HXC9_HUMAN Homeobox protein Hox-C9 (sprot)

description: A homeobox protein Hox-C9 that is encoded in the genome of human.


name: HXC12_HUMAN Homeobox protein Hox-C12 (sprot)

description: A homeobox protein Hox-C12 that is encoded in the genome of human.


name: HXC13_HUMAN Homeobox protein Hox-C13 (sprot)

description: A homeobox protein Hox-C13 that is encoded in the genome of human.


name: HXD11_HUMAN Homeobox protein Hox-D11 (sprot)

description: A homeobox protein Hox-D11 that is encoded in the genome of human.


name: TLX1_HUMAN T-cell leukemia homeobox protein 1 (sprot)

description: A T-cell leukemia homeobox protein 1 that is encoded in the genome of human.


name: KAP1_HUMAN cAMP-dependent protein kinase type I-beta regulatory subunit (sprot)

description: A cAMP-dependent protein kinase type I-beta regulatory subunit that is encoded in the genome of human.


positive regulation of fear response

description: Any process that activates or increases the frequency, rate or extent of fear response.


name: KAP3_HUMAN cAMP-dependent protein kinase type II-beta regulatory subunit (sprot)

description: A cAMP-dependent protein kinase type II-beta regulatory subunit that is encoded in the genome of human.


response to antipsychotic drug

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antipsychotic drug stimulus. Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.


name: CPSM_HUMAN Carbamoyl-phosphate synthase [ammonia], mitochondrial (sprot)

description: A carbamoyl-phosphate synthase [ammonia], mitochondrial that is encoded in the genome of human.


name: carbamoyl phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways.


name: RIR2_HUMAN Ribonucleoside-diphosphate reductase subunit M2 (sprot)

description: A ribonucleoside-diphosphate reductase subunit M2 that is encoded in the genome of human.


CD52_HUMAN CAMPATH-1 antigen (sprot)

A CAMPATH-1 antigen that is encoded in the genome of human.


name: FGF9_HUMAN Fibroblast growth factor 9 (sprot)

description: A fibroblast growth factor 9 that is encoded in the genome of human.


name: SSR4_HUMAN Somatostatin receptor type 4 (sprot)

description: A somatostatin receptor type 4 that is encoded in the genome of human.


CASQ1_HUMAN Calsequestrin-1 (sprot)

A calsequestrin-1 that is encoded in the genome of human.


name: positive regulation of store-operated calcium channel activity

description: Any process that activates or increases the frequency, rate or extent of store-operated calcium channel activity.


terminal cisterna lumen

description: The region between the inner and outer lipid bilayers of the terminal cisterna envelope. This space is enriched in calsequestrin.


SDC4_HUMAN Syndecan-4 (sprot)

A syndecan-4 that is encoded in the genome of human.


name: TIA1_HUMAN Cytotoxic granule associated RNA binding protein TIA1 (sprot)

description: A cytotoxic granule associated RNA binding protein TIA1 that is encoded in the genome of human.


nuclear stress granule

description: A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.


name: FMO4_HUMAN Dimethylaniline monooxygenase [N-oxide-forming] 4 (sprot)

description: A dimethylaniline monooxygenase [N-oxide-forming] 4 that is encoded in the genome of human.


description: Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.


name: FMO3_HUMAN Flavin-containing monooxygenase 3 (sprot)

description: A flavin-containing monooxygenase 3 that is encoded in the genome of human.


trimethylamine monooxygenase activity

description: Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O.


albendazole monooxygenase activity

description: Catalysis of the reaction: albendazole + H+ + NADPH + O2 = albendazole S-oxide + H2O + NADP+.


taurine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats.


name: ZEP2_HUMAN Transcription factor HIVEP2 (sprot)

description: A transcription factor HIVEP2 that is encoded in the genome of human.


name: SC5A2_HUMAN Sodium/glucose cotransporter 2 (sprot)

description: A sodium/glucose cotransporter 2 that is encoded in the genome of human.


name: low-affinity glucose:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.


name: SC6A6_HUMAN Sodium- and chloride-dependent taurine transporter (sprot)

description: A sodium- and chloride-dependent taurine transporter that is encoded in the genome of human.


nitrogen compound transport

description: The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


amino acid:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in).


name: taurine:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in).


name: alanine transmembrane transporter activity

description: Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid.


alanine transport

description: The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-5 that is encoded in the genome of human.


name: SC6A4_HUMAN Sodium-dependent serotonin transporter (sprot)

description: A sodium-dependent serotonin transporter that is encoded in the genome of human.


description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in).


cocaine binding

description: Binding to cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis.


name: positive regulation of serotonin secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin.


name: negative regulation of cerebellar granule cell precursor proliferation

description: The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation.


name: negative regulation of synaptic transmission, dopaminergic

description: Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.


regulation of thalamus size

description: Any process that modulates the size of the thalamus. The thalamus is a part of the diencephalon that is composed of the dorsal thalamus and the ventral thalamus.


conditioned place preference

description: The associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug.


name: DNJA1_HUMAN DnaJ homolog subfamily A member 1 (sprot)

description: A DnaJ homolog subfamily A member 1 that is encoded in the genome of human.


name: negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress.


name: AKT1_HUMAN RAC-alpha serine/threonine-protein kinase (sprot)

description: A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of human.


potassium channel activator activity

description: Binds to and increases the activity of a potassium channel, resulting in its opening.


name: regulation of glycogen biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.


name: virus-mediated perturbation of host defense response

description: A process in which a virus interferes with the ability of the host to mount a defense in response to its presence. Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction.


mammalian oogenesis stage

description: A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell.


name: cellular response to decreased oxygen levels

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.


regulation of tRNA methylation

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA methylation.


name: positive regulation of protein localization to endoplasmic reticulum

description: Any process that activates or increases the frequency, rate or extent of protein localization to endoplasmic reticulum.


name: AKT2_HUMAN RAC-beta serine/threonine-protein kinase (sprot)

description: A RAC-beta serine/threonine-protein kinase that is encoded in the genome of human.


name: cellular response to high light intensity

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus.


retinal rod cell apoptotic process

description: Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina.


name: IL2RG_HUMAN Cytokine receptor common subunit gamma (sprot)

description: A cytokine receptor common subunit gamma that is encoded in the genome of human.


mature B cell differentiation

description: The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.


name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.


name: QCR1_HUMAN Cytochrome b-c1 complex subunit 1, mitochondrial (sprot)

description: A cytochrome b-c1 complex subunit 1, mitochondrial that is encoded in the genome of human.


name: 3HIDH_HUMAN 3-hydroxyisobutyrate dehydrogenase, mitochondrial (sprot)

description: A 3-hydroxyisobutyrate dehydrogenase, mitochondrial that is encoded in the genome of human.


description: Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+.


valine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.


name: PUR9_HUMAN Bifunctional purine biosynthesis protein ATIC (sprot)

description: A bifunctional purine biosynthesis protein ATIC that is encoded in the genome of human.


IMP cyclohydrolase activity

description: Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide.


name: ABC3A_HUMAN DNA dC->dU-editing enzyme APOBEC-3A (sprot)

description: A DNA dC->dU-editing enzyme APOBEC-3A that is encoded in the genome of human.


cytidine deaminase activity

description: Catalysis of the reaction: cytidine + H+ + H2O = uridine + NH4 and deoxycytidine + H+ + H2O = deoxyuridine + NH4+.


cytidine deamination

description: The removal of amino group in the presence of water.


clearance of foreign intracellular DNA

description: A defense process that protects an organism from invading foreign DNA.


name: HNRH3_HUMAN Heterogeneous nuclear ribonucleoprotein H3 (sprot)

description: A heterogeneous nuclear ribonucleoprotein H3 that is encoded in the genome of human.


name: HNRH1_HUMAN Heterogeneous nuclear ribonucleoprotein H (sprot)

description: A heterogeneous nuclear ribonucleoprotein H that is encoded in the genome of human.


CASPE_HUMAN Caspase-14 (sprot)

A caspase-14 that is encoded in the genome of human.


cornification

description: A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).


name: 1433B_HUMAN 14-3-3 protein beta/alpha (sprot)

description: A 14-3-3 protein beta/alpha that is encoded in the genome of human.


phosphoserine residue binding

description: Binding to a phosphorylated serine residue within a protein.


name: 1433S_HUMAN 14-3-3 protein sigma (sprot)

description: A 14-3-3 protein sigma that is encoded in the genome of human.


regulation of epidermal cell division

description: Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis.


name: STIP1_HUMAN Stress-induced-phosphoprotein 1 (sprot)

description: A stress-induced-phosphoprotein 1 that is encoded in the genome of human.


S10AB_HUMAN Protein S100-A11 (sprot)

A protein S100-A11 that is encoded in the genome of human.


name: FCG2B_HUMAN Low affinity immunoglobulin gamma Fc region receptor II-b (sprot)

description: A low affinity immunoglobulin gamma Fc region receptor II-b that is encoded in the genome of human.


name: negative regulation of type I hypersensitivity

description: Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response.


name: negative regulation of antibody-dependent cellular cytotoxicity

description: Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity.


immune effector process

description: Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation.


follicular dendritic cell activation

description: A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand.


name: mature B cell differentiation involved in immune response

description: The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response.


name: immune complex clearance by monocytes and macrophages

description: The process of immune complex clearance by monocytes or macrophages.


name: regulation of B cell antigen processing and presentation

description: Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation.


name: negative regulation of acute inflammatory response to antigenic stimulus

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.


name: regulation of immune complex clearance by monocytes and macrophages

description: Any process that modulates the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages.


name: regulation of dendritic spine maintenance

description: Any process that modulates the frequency, rate or extent of dendritic spine maintenance.


name: regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway

description: Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway.


name: positive regulation of response to endoplasmic reticulum stress

description: Any process that activates or increases the frequency, rate or extent of response to endoplasmic reticulum stress.


name: FCG2C_HUMAN Low affinity immunoglobulin gamma Fc region receptor II-c (sprot)

description: A low affinity immunoglobulin gamma Fc region receptor II-c that is encoded in the genome of human.


name: CEAM8_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 8 (sprot)

description: A carcinoembryonic antigen-related cell adhesion molecule 8 that is encoded in the genome of human.


name: L1CAM_HUMAN Neural cell adhesion molecule L1 (sprot)

description: A neural cell adhesion molecule L1 that is encoded in the genome of human.


name: I5P2_HUMAN Type II inositol 1,4,5-trisphosphate 5-phosphatase (sprot)

description: A type II inositol 1,4,5-trisphosphate 5-phosphatase that is encoded in the genome of human.


description: Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.


PRDX2_HUMAN Peroxiredoxin-2 (sprot)

A peroxiredoxin-2 that is encoded in the genome of human.


name: respiratory burst involved in inflammatory response

description: A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels.


ARRB2_HUMAN Beta-arrestin-2 (sprot)

A beta-arrestin-2 that is encoded in the genome of human.


angiotensin receptor binding

description: Binding to an angiotensin receptor.


D1 dopamine receptor binding

description: Binding to a D1 dopamine receptor.


postsynaptic signal transduction

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Signal transduction in which the initial step occurs in a postsynapse.


GLPK_HUMAN Glycerol kinase (sprot)

A glycerol kinase that is encoded in the genome of human.


glycerol kinase activity

description: Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+.


glycerol metabolic process

description: The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.


glycerol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.


description: The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol.


name: CCKAR_HUMAN Cholecystokinin receptor type A (sprot)

description: A cholecystokinin receptor 1 that is encoded in the genome of human.


cholecystokinin receptor activity

description: Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone.


cholecystokinin signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by cholecystokinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: GASR_HUMAN Gastrin/cholecystokinin type B receptor (sprot)

description: A cholecystokinin receptor 2 that is encoded in the genome of human.


gastrin receptor activity

description: Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity.


name: type B gastrin/cholecystokinin receptor binding

description: Binding to a type B gastrin/cholecystokinin receptor.


description: Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity.


name: VIPR1_HUMAN Vasoactive intestinal polypeptide receptor 1 (sprot)

description: A vasoactive intestinal polypeptide receptor 1 that is encoded in the genome of human.


name: vasoactive intestinal polypeptide receptor activity

description: Combining with vasoactive intestinal polypeptide to initiate a change in cell activity.


name: OTX1_HUMAN Homeobox protein OTX1 (sprot)

description: A homeobox protein OTX1 that is encoded in the genome of human.


metencephalon development

description: The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure.


diencephalon morphogenesis

description: The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.


name: OTX2_HUMAN Homeobox protein OTX2 (sprot)

description: A homeobox protein OTX2 that is encoded in the genome of human.


name: regulation of fibroblast growth factor receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.


positive regulation of gastrulation

description: Any process that activates or increases the frequency, rate or extent of gastrulation.


name: MC4R_HUMAN Melanocortin receptor 4 (sprot)

description: A melanocortin receptor 4 that is encoded in the genome of human.


melanocortin receptor activity

description: Combining with melanocortin to initiate a change in cell activity.


name: melanocyte-stimulating hormone receptor activity

description: Combining with melanocyte-stimulating hormone to initiate a change in cell activity.


regulation of eating behavior

description: Any process that modulates the frequency, rate or extent of eating behavior.


regulation of grooming behavior

description: Any process that modulates the frequency, rate or extent of grooming behavior.


name: CCR1_HUMAN C-C chemokine receptor type 1 (sprot)

description: A C-C chemokine receptor type 1 that is encoded in the genome of human.


chemokine (C-C motif) ligand 7 binding

description: Binding to chemokine (C-C motif) ligand 7.


chemokine (C-C motif) ligand 5 binding

description: Binding to chemokine (C-C motif) ligand 5.


name: BRS3_HUMAN Bombesin receptor subtype-3 (sprot)

description: A bombesin receptor subtype-3 that is encoded in the genome of human.


name: CCR7_HUMAN C-C chemokine receptor type 7 (sprot)

description: A C-C chemokine receptor type 7 that is encoded in the genome of human.


chemokine (C-C motif) ligand 19 binding

description: Binding to chemokine (C-C motif) ligand 19.


chemokine (C-C motif) ligand 21 binding

description: Binding to chemokine (C-C motif) ligand 21.


name: C-C motif chemokine 19 receptor activity

description: Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: C-C motif chemokine 21 receptor activity

description: Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


myeloid dendritic cell chemotaxis

description: The movement of a myeloid dendritic cell in response to an external stimulus.


positive regulation of hypersensitivity

description: Any process that activates or increases the frequency, rate, or extent of hypersensitivity.


name: chemokine (C-C motif) ligand 19 signaling pathway

description: The series of molecular signals initiated by the binding of the C-C chemokine CCL19 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: positive regulation of immunological synapse formation

description: Any process that activates or increases the frequency, rate or extent of immunological synapse formation.


name: positive regulation of T cell costimulation

description: Any process that activates or increases the frequency, rate or extent of T cell costimulation.


name: positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation

description: Any positive regulation of glycoprotein biosynthetic process that is involved in immunological synapse formation.


name: regulation of dendritic cell dendrite assembly

description: Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly.


name: GP183_HUMAN G-protein coupled receptor 183 (sprot)

description: A G-protein coupled receptor 183 that is encoded in the genome of human.


regulation of astrocyte chemotaxis

description: Any process that modulates the frequency, rate or extent of astrocyte chemotaxis.


name: ACHA3_HUMAN Neuronal acetylcholine receptor subunit alpha-3 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-3 that is encoded in the genome of human.


name: regulation of acetylcholine secretion, neurotransmission

description: Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine.


name: GRK4_HUMAN G protein-coupled receptor kinase 4 (sprot)

description: A G protein-coupled receptor kinase 4 that is encoded in the genome of human.


rhodopsin kinase activity

description: Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin.


name: CXCR5_HUMAN C-X-C chemokine receptor type 5 (sprot)

description: A C-X-C chemokine receptor type 5 that is encoded in the genome of human.


name: FOXN2_HUMAN Forkhead box protein N2 (sprot)

description: A forkhead box protein N2 that is encoded in the genome of human.


CDD_HUMAN Cytidine deaminase (sprot)

A cytidine deaminase that is encoded in the genome of human.


pyrimidine-containing compound salvage

description: Any process that generates a pyrimidine-containing compound, a nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis.


name: negative regulation of nucleotide metabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.


response to cycloheximide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes.


name: cellular response to external biotic stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.


name: DCTD_HUMAN Deoxycytidylate deaminase (sprot)

description: A deoxycytidylate deaminase that is encoded in the genome of human.


name: P5CR1_HUMAN Pyrroline-5-carboxylate reductase 1, mitochondrial (sprot)

description: A pyrroline-5-carboxylate reductase 1, mitochondrial that is encoded in the genome of human.


description: Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.


proline biosynthetic process

description: The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.


name: NAC1_HUMAN Sodium/calcium exchanger 1 (sprot)

description: A sodium/calcium exchanger 1 that is encoded in the genome of human.


relaxation of smooth muscle

description: A process in which the extent of smooth muscle contraction is reduced. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.


name: GBP1_HUMAN Guanylate-binding protein 1 (sprot)

description: A guanylate-binding protein 1 that is encoded in the genome of human.


cytolysis in another organism

description: The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm.


name: positive regulation of pyroptotic inflammatory response

description: Any process that increases the frequency, rate or extent of a pyroptotic inflammatory response.


name: GBP2_HUMAN Guanylate-binding protein 2 (sprot)

description: A guanylate-binding protein 2 that is encoded in the genome of human.


name: positive regulation of AIM2 inflammasome complex assembly

description: Any process that activates or increases the frequency, rate or extent of AIM2 inflammasome complex assembly.


name: ELF1_HUMAN ETS-related transcription factor Elf-1 (sprot)

description: An ETS-related transcription factor Elf-1 that is encoded in the genome of human.


name: SSR3_HUMAN Somatostatin receptor type 3 (sprot)

description: A somatostatin receptor type 3 that is encoded in the genome of human.


name: HPPD_HUMAN 4-hydroxyphenylpyruvate dioxygenase (sprot)

description: A 4-hydroxyphenylpyruvate dioxygenase that is encoded in the genome of human.


description: Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.


name: TF2H1_HUMAN General transcription factor IIH subunit 1 (sprot)

description: A general transcription factor IIH subunit 1 that is encoded in the genome of human.


STX2_HUMAN Syntaxin-2 (sprot)

A syntaxin-2 that is encoded in the genome of human.


IFNA8_HUMAN Interferon alpha-8 (sprot)

An interferon alpha-8 that is encoded in the genome of human.


DSG3_HUMAN Desmoglein-3 (sprot)

A desmoglein-3 that is encoded in the genome of human.


name: IL3RB_HUMAN Cytokine receptor common subunit beta (sprot)

description: A cytokine receptor common subunit beta that is encoded in the genome of human.


interleukin-5 receptor activity

description: Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: CGL_HUMAN Cystathionine gamma-lyase (sprot)

description: A cystathionine gamma-lyase that is encoded in the genome of human.


cystathionine gamma-lyase activity

description: Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.


description: Catalysis of the reaction: L-cystine + H2O = pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide.


homocysteine desulfhydrase activity

description: Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate.


L-cysteine desulfhydrase activity

description: Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+.


description: Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid.


cysteine metabolic process

description: The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.


name: protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

description: The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine.


name: cysteine biosynthetic process via cystathionine

description: The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine.


protein sulfhydration

description: The modification of a protein amino acid by the addition of sulfur.


name: ICAM3_HUMAN Intercellular adhesion molecule 3 (sprot)

description: An intercellular adhesion molecule 3 that is encoded in the genome of human.


name: RL9_HUMAN Large ribosomal subunit protein uL6 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL6 that is encoded in the genome of human.


CD70_HUMAN CD70 antigen (sprot)

A CD70 molecule that is encoded in the genome of human.


name: TNFL8_HUMAN Tumor necrosis factor ligand superfamily member 8 (sprot)

description: A tumor necrosis factor ligand superfamily member 8 that is encoded in the genome of human.


name: MC5R_HUMAN Melanocortin receptor 5 (sprot)

description: A melanocortin receptor 5 that is encoded in the genome of human.


name: C2TA_HUMAN MHC class II transactivator (sprot)

description: An MHC class II transactivator that is encoded in the genome of human.


name: ACSL1_HUMAN Long-chain-fatty-acid--CoA ligase 1 (sprot)

description: A long-chain-fatty-acid--CoA ligase 1 that is encoded in the genome of human.


oleoyl-CoA ligase activity

description: Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA.


name: positive regulation of long-chain fatty acid import across plasma membrane

description: Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


adiponectin-activated signaling pathway

description: The series of molecular signals initiated by adiponectin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


response to oleic acid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus.


CADH5_HUMAN Cadherin-5 (sprot)

A cadherin-5 that is encoded in the genome of human.


name: KINH_HUMAN Kinesin-1 heavy chain (sprot)

description: A kinesin-1 heavy chain that is encoded in the genome of human.


cytoplasm organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.


name: CSTF2_HUMAN Cleavage stimulation factor subunit 2 (sprot)

description: A cleavage stimulation factor subunit 2 that is encoded in the genome of human.


cleavage body

description: A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing.


name: LSP1_HUMAN Lymphocyte-specific protein 1 (sprot)

description: A lymphocyte-specific protein 1 that is encoded in the genome of human.


name: CP2CI_HUMAN Cytochrome P450 2C18 (sprot)

description: A cytochrome P450 2C18 that is encoded in the genome of human.


linoleic acid epoxygenase activity

description: Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid.


name: CP2CJ_HUMAN Cytochrome P450 2C19 (sprot)

description: A cytochrome P450 2C19 that is encoded in the genome of human.


name: DUT_HUMAN Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (sprot)

description: A deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial that is encoded in the genome of human.


dUTP diphosphatase activity

description: Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate.


dUMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate).


name: GCYA2_HUMAN Guanylate cyclase soluble subunit alpha-2 (sprot)

description: A guanylate cyclase soluble subunit alpha-2 that is encoded in the genome of human.


name: MRP1_HUMAN Multidrug resistance-associated protein 1 (sprot)

description: A multidrug resistance-associated protein 1 that is encoded in the genome of human.


name: ATPase-coupled lipid transmembrane transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out).


cyclic nucleotide transport

description: The directed movement of a cyclic nucleotide, any nucleotide in which phosphate group is in diester linkage to two positions on the sugar residue, into, out of or within a cell.


name: CKS2_HUMAN Cyclin-dependent kinases regulatory subunit 2 (sprot)

description: A cyclin-dependent kinases regulatory subunit 2 that is encoded in the genome of human.


meiosis I

description: The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei.


mitotic cell cycle phase transition

description: The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.


name: CD80_HUMAN T-lymphocyte activation antigen CD80 (sprot)

description: A CD80 molecule that is encoded in the genome of human.


name: negative regulation of T cell mediated immunity

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.


S10A5_HUMAN Protein S100-A5 (sprot)

A protein S100-A5 that is encoded in the genome of human.


S10A3_HUMAN Protein S100-A3 (sprot)

A protein S100-A3 that is encoded in the genome of human.


name: H2B1B_HUMAN Histone H2B type 1-B (sprot)

description: A histone H2B type 1-B that is encoded in the genome of human.


name: ABCD1_HUMAN ATP-binding cassette sub-family D member 1 (sprot)

description: An ATP-binding cassette sub-family D member 1 that is encoded in the genome of human.


name: ABC-type fatty-acyl-CoA transporter activity

description: Catalysis of the reaction ATP + H2O + fatty acyl CoA(Side 1) = ADP + phosphate + fatty acyl CoA(Side 2). A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it.


name: very long-chain fatty acyl-CoA hydrolase activity

description: Catalysis of the reaction: a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H+. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.


fatty-acyl-CoA transport

description: The directed movement of fatty acyl coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acyl coenzyme A is an acyl group linked to 3'-phosphoadenosine-(5')diphospho(4')pantatheine (coenzyme A).


peroxisomal membrane transport

description: The directed movement of substances to, from or across the peroxisomal membrane.


fatty acid elongation

description: The elongation of a fatty acid chain by the sequential addition of two-carbon units.


name: very long-chain fatty-acyl-CoA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a very long-chain fatty-acyl group. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.


long-chain fatty acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


name: regulation of mitochondrial depolarization

description: Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.


name: positive regulation of unsaturated fatty acid biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process.


name: MA1A1_HUMAN Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (sprot)

description: A mannosyl-oligosaccharide 1,2-alpha-mannosidase IA that is encoded in the genome of human.


mannosidase activity

description: Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative.


protein targeting to ER

description: The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.


name: mannose trimming involved in glycoprotein ERAD pathway

description: The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD).


name: ERD22_HUMAN ER lumen protein-retaining receptor 2 (sprot)

description: An ER lumen protein-retaining receptor 2 that is encoded in the genome of human.


name: TTK_HUMAN Dual specificity protein kinase TTK (sprot)

description: A dual specificity protein kinase TTK that is encoded in the genome of human.


kinetochore binding

description: Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached.


name: protein localization to meiotic spindle midzone

description: A process in which a protein is transported to, or maintained in, a location within a meiotic spindle midzone.


name: MCM4_HUMAN DNA replication licensing factor MCM4 (sprot)

description: A DNA replication licensing factor MCM4 that is encoded in the genome of human.


name: MCM5_HUMAN DNA replication licensing factor MCM5 (sprot)

description: A DNA replication licensing factor MCM5 that is encoded in the genome of human.


name: MCM7_HUMAN DNA replication licensing factor MCM7 (sprot)

description: A DNA replication licensing factor MCM7 that is encoded in the genome of human.


An N-acetylgalactosamine-6-sulfatase that is encoded in the genome of human.


description: Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.


RNAS4_HUMAN Ribonuclease 4 (sprot)

A ribonuclease 4 that is encoded in the genome of human.


NTF4_HUMAN Neurotrophin-4 (sprot)

A neurotrophin-4 that is encoded in the genome of human.


sensory organ boundary specification

description: The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained.


taste bud development

description: The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors.


SDC2_HUMAN Syndecan-2 (sprot)

A syndecan-2 that is encoded in the genome of human.


CD68_HUMAN Macrosialin (sprot)

A macrosialin that is encoded in the genome of human.


name: BMP8B_HUMAN Bone morphogenetic protein 8B (sprot)

description: A bone morphogenetic protein 8B that is encoded in the genome of human.


name: GLYC_HUMAN Serine hydroxymethyltransferase, cytosolic (sprot)

description: A serine hydroxymethyltransferase, cytosolic that is encoded in the genome of human.


description: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.


serine binding

description: Binding to 2-amino-3-hydroxypropanoic acid.


cellular response to tetrahydrofolate

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus.


name: GLYM_HUMAN Serine hydroxymethyltransferase, mitochondrial (sprot)

description: A serine hydroxymethyltransferase, mitochondrial that is encoded in the genome of human.


L-allo-threonine aldolase activity

description: Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde.


regulation of mitochondrial translation

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.


BRISC complex

description: A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains.


name: GBRA3_HUMAN Gamma-aminobutyric acid receptor subunit alpha-3 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-3 that is encoded in the genome of human.


EVI2B_HUMAN Protein EVI2B (sprot)

A protein EVI2B that is encoded in the genome of human.


name: positive regulation of neutrophil differentiation

description: Any process that activates or increases the frequency, rate or extent of neutrophil differentiation.


name: HYES_HUMAN Bifunctional epoxide hydrolase 2 (sprot)

description: An epoxide hydrolase 2 that is encoded in the genome of human.


description: Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate.


stilbene catabolic process

description: The chemical reactions and pathways resulting in the breakdown of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA.


name: RYK_HUMAN Tyrosine-protein kinase RYK (sprot)

description: A tyrosine-protein kinase RYK that is encoded in the genome of human.


name: chemorepulsion of dopaminergic neuron axon

description: The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.


name: HS71L_HUMAN Heat shock 70 kDa protein 1-like (sprot)

description: A heat shock 70 kDa protein 1-like that is encoded in the genome of human.


name: HSP74_HUMAN Heat shock 70 kDa protein 4 (sprot)

description: A heat shock 70 kDa protein 4 that is encoded in the genome of human.


name: GRK5_HUMAN G protein-coupled receptor kinase 5 (sprot)

description: A G protein-coupled receptor kinase 5 that is encoded in the genome of human.


name: MPI_HUMAN Mannose-6-phosphate isomerase (sprot)

description: A mannose-6-phosphate isomerase that is encoded in the genome of human.


mannose-6-phosphate isomerase activity

description: Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate.


name: mannose to fructose-6-phosphate catabolic process

description: The chemical reactions and pathways in which mannose, the aldohexose manno-hexose, is converted to fructose-6-phosphate.


name: 5HT7R_HUMAN 5-hydroxytryptamine receptor 7 (sprot)

description: A 5-hydroxytryptamine receptor 7 that is encoded in the genome of human.


name: CNR2_HUMAN Cannabinoid receptor 2 (sprot)

description: A cannabinoid receptor 2 that is encoded in the genome of human.


name: TRFR_HUMAN Thyrotropin-releasing hormone receptor (sprot)

description: A thyrotropin-releasing hormone receptor type 1 that is encoded in the genome of human.


name: OR1D2_HUMAN Olfactory receptor 1D2 (sprot)

description: An olfactory receptor 1D2 that is encoded in the genome of human.


name: PE2R1_HUMAN Prostaglandin E2 receptor EP1 subtype (sprot)

description: A prostaglandin E2 receptor EP1 subtype that is encoded in the genome of human.


name: CRFR1_HUMAN Corticotropin-releasing factor receptor 1 (sprot)

description: A corticotropin-releasing factor receptor 1 that is encoded in the genome of human.


name: corticotrophin-releasing factor receptor activity

description: Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity.


name: regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G protein-coupled receptor signaling pathway.


regulation of corticosterone secretion

description: Any process that modulates the frequency, rate or extent of corticosterone secretion.


TRY3_HUMAN Trypsin-3 (sprot)

A trypsin-3 that is encoded in the genome of human.


GPC1_HUMAN Glypican-1 (sprot)

A glypican-1 that is encoded in the genome of human.


BTC_HUMAN Probetacellulin (sprot)

A probetacellulin that is encoded in the genome of human.


PROF2_HUMAN Profilin-2 (sprot)

A profilin-2 that is encoded in the genome of human.


name: UBP6_HUMAN Ubiquitin carboxyl-terminal hydrolase 6 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 6 that is encoded in the genome of human.


name: CXA4_HUMAN Gap junction alpha-4 protein (sprot)

description: A gap junction alpha-4 protein that is encoded in the genome of human.


name: CAH5A_HUMAN Carbonic anhydrase 5A, mitochondrial (sprot)

description: A carbonic anhydrase 5A, mitochondrial that is encoded in the genome of human.


name: CAH8_HUMAN Carbonic anhydrase-related protein (sprot)

description: A carbonic anhydrase-related protein that is encoded in the genome of human.


CTNA1_HUMAN Catenin alpha-1 (sprot)

A catenin alpha-1 that is encoded in the genome of human.


CTNB1_HUMAN Catenin beta-1 (sprot)

A catenin beta-1 that is encoded in the genome of human.


endodermal cell fate commitment

description: The cell differentiation process that results in commitment of a cell to become part of the endoderm.


name: regulation of secondary heart field cardioblast proliferation

description: Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).


name: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

description: Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.


glial cell fate determination

description: The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed.


name: positive regulation of heparan sulfate proteoglycan biosynthetic process

description: Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues.


name: regulation of centriole-centriole cohesion

description: Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker.


name: embryonic skeletal limb joint morphogenesis

description: The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb.


name: canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation

description: The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation.


name: negative regulation of mitotic cell cycle, embryonic

description: Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle.


embryonic foregut morphogenesis

description: The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase.


regulation of timing of anagen

description: Any process that modulates the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle.


name: epithelial cell proliferation involved in prostate gland development

description: The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time.


hair follicle placode formation

description: The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud.


endothelial tube morphogenesis

description: The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.


fungiform papilla formation

description: The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue.


cranial ganglion development

description: The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.


name: regulation of centromeric sister chromatid cohesion

description: Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome.


renal vesicle formation

description: The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells.


renal inner medulla development

description: The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney.


renal outer medulla development

description: The process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla.


nephron tubule formation

description: The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney.


mesenchymal stem cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.


name: positive regulation of determination of dorsal identity

description: Any process that activates or increases the frequency, rate or extent of determination of dorsal identity.


Scrib-APC-beta-catenin complex

description: A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation.


beta-catenin-ICAT complex

description: Transcription factor complex that inhibits binding of Tcf to beta-catenin while preserving interaction of catenin with cadherin thus inhibiting transcription mediated by beta-catenin-Tcf complex.


IL13_HUMAN Interleukin-13 (sprot)

An interleukin-13 that is encoded in the genome of human.


interleukin-13 receptor binding

description: Binding to an interleukin-13 receptor.


name: negative regulation of lung ciliated cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation.


name: positive regulation of lung goblet cell differentiation

description: Any process that activates or increases the frequency, rate or extent of lung goblet cell differentiation.


name: positive regulation of pancreatic stellate cell proliferation

description: Any process that activates or increases the frequency, rate or extent of pancreatic stellate cell proliferation.


name: BMI1_HUMAN Polycomb complex protein BMI-1 (sprot)

description: A Polycomb complex protein BMI-1 that is encoded in the genome of human.


RING-like zinc finger domain binding

description: Binding to a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain.


name: ubiquitin-protein transferase activator activity

description: Binds to and increases the activity of a ubiquitin-protein transferase.


name: regulation of adaxial/abaxial pattern formation

description: Any process that modulates the frequency, rate or extent of adaxial/abaxial pattern formation.


name: PCGF2_HUMAN Polycomb group RING finger protein 2 (sprot)

description: A Polycomb group RING finger protein 2 that is encoded in the genome of human.


name: NOS2_HUMAN Nitric oxide synthase, inducible (sprot)

description: A nitric oxide synthase, inducible that is encoded in the genome of human.


name: positive regulation of leukocyte mediated cytotoxicity

description: Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity.


regulation of cellular respiration

description: Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds.


PHB1_HUMAN Prohibitin 1 (sprot)

A prohibitin 1 that is encoded in the genome of human.


complement component C3a binding

description: Binding to a C3a product of the complement cascade.


proteinase activated receptor binding

description: Binding to a proteinase activated receptor.


name: modulation by host of viral RNA genome replication

description: A process in which a host organism modulates the frequency, rate or extent of viral RNA genome replication.


mitochondrial prohibitin complex

description: A complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death.


name: PTN7_HUMAN Tyrosine-protein phosphatase non-receptor type 7 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 7 that is encoded in the genome of human.


SPB6_HUMAN Serpin B6 (sprot)

A serpin B6 that is encoded in the genome of human.


MERL_HUMAN Merlin (sprot)

A merlin that is encoded in the genome of human.


regulation of hippo signaling

description: Any process that modulates the frequency, rate or extent of hippo signaling.


RADI_HUMAN Radixin (sprot)

A radixin that is encoded in the genome of human.


name: regulation of actin filament bundle assembly

description: Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles.


name: negative regulation of homotypic cell-cell adhesion

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion.


negative regulation of cell size

description: Any process that reduces cell size.


name: establishment of protein localization to plasma membrane

description: The directed movement of a protein to a specific location in a plasma membrane.


stereocilium base

description: The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium.


RECO_HUMAN Recoverin (sprot)

A recoverin that is encoded in the genome of human.


name: calcium sensitive guanylate cyclase activator activity

description: Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.


name: RFA3_HUMAN Replication protein A 14 kDa subunit (sprot)

description: A replication protein A 14 kDa subunit that is encoded in the genome of human.


name: SFTPD_HUMAN Pulmonary surfactant-associated protein D (sprot)

description: A pulmonary surfactant-associated protein D that is encoded in the genome of human.


name: RFC4_HUMAN Replication factor C subunit 4 (sprot)

description: A replication factor C subunit 4 that is encoded in the genome of human.


DNA replication factor C complex

description: A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides.


Elg1 RFC-like complex

description: A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.


name: RFC2_HUMAN Replication factor C subunit 2 (sprot)

description: A replication factor C subunit 2 that is encoded in the genome of human.


name: RFC1_HUMAN Replication factor C subunit 1 (sprot)

description: A replication factor C subunit 1 that is encoded in the genome of human.


DNA clamp unloader activity

description: Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis.


DNA clamp unloading

description: The process of removing the PCNA complex from DNA when Okazaki fragments are completed or the replication fork terminates.


name: RL22_HUMAN Large ribosomal subunit protein eL22 (sprot)

description: A large ribosomal subunit protein eL22 that is encoded in the genome of human.


translation at presynapse

description: Translation that occurs at the presynapse.


name: T2FA_HUMAN General transcription factor IIF subunit 1 (sprot)

description: A general transcription factor IIF subunit 1 that is encoded in the genome of human.


name: SPRE_HUMAN Sepiapterin reductase (sprot)

description: A sepiapterin reductase that is encoded in the genome of human.


sepiapterin reductase (NADP+) activity

description: Catalysis of the reactions: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H+ + 2 NADPH.


ADML_HUMAN Pro-adrenomedullin (sprot)

A pro-adrenomedullin that is encoded in the genome of human.


adrenomedullin receptor binding

description: Binding to an adrenomedullin receptor.


name: positive regulation of progesterone biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of progesterone biosynthetic process.


SPR1A_HUMAN Cornifin-A (sprot)

A cornifin-A that is encoded in the genome of human.


name: SPR2B_HUMAN Small proline-rich protein 2B (sprot)

description: A small proline-rich protein 2B that is encoded in the genome of human.


name: SPR2A_HUMAN Small proline-rich protein 2A (sprot)

description: A small proline-rich protein 2A that is encoded in the genome of human.


name: host-mediated regulation of intestinal microbiota composition

description: The biological process involved in maintaining the steady-state number of cells within a population of free-living cells such as the bacteria in the gut.


name: SSR5_HUMAN Somatostatin receptor type 5 (sprot)

description: A somatostatin receptor type 5 that is encoded in the genome of human.


name: ADA1A_HUMAN Alpha-1A adrenergic receptor (sprot)

description: An alpha-1A adrenergic receptor that is encoded in the genome of human.


alpha1-adrenergic receptor activity

description: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.


name: negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

description: Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure.


name: PGH2_HUMAN Prostaglandin G/H synthase 2 (sprot)

description: A prostaglandin G/H synthase 2 that is encoded in the genome of human.


name: cellular response to non-ionic osmotic stress

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment.


cellular response to homocysteine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a homocysteine stimulus.


name: HRH1_HUMAN Histamine H1 receptor (sprot)

description: A histamine H1 receptor that is encoded in the genome of human.


name: ADA1B_HUMAN Alpha-1B adrenergic receptor (sprot)

description: An alpha-1B adrenergic receptor that is encoded in the genome of human.


name: OPRM_HUMAN Mu-type opioid receptor (sprot)

description: A mu-type opioid receptor that is encoded in the genome of human.


beta-endorphin receptor activity

description: Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC).


morphine receptor activity

description: Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein.


name: adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

description: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor, and ending with the regulation of a downstream cellular process.


name: negative regulation of Wnt protein secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a Wnt protein from a cell.


cellular response to morphine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.


name: RORA_HUMAN Nuclear receptor ROR-alpha (sprot)

description: A nuclear receptor ROR-alpha that is encoded in the genome of human.


regulation of steroid metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.


T-helper 17 cell differentiation

description: The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.


name: PE2R4_HUMAN Prostaglandin E2 receptor EP4 subtype (sprot)

description: A prostaglandin E2 receptor EP4 subtype that is encoded in the genome of human.


name: negative regulation of integrin activation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of integrin activation.


name: negative regulation of eosinophil extravasation

description: Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil extravasation.


name: MAS1L_HUMAN Mas-related G-protein coupled receptor MRG (sprot)

description: A Mas-related G-protein coupled receptor MRG that is encoded in the genome of human.


APJ_HUMAN Apelin receptor (sprot)

An apelin receptor that is encoded in the genome of human.


regulation of gap junction assembly

description: Any process that modulates the frequency, rate or extent of gap junction assembly.


atrioventricular valve development

description: The progression of the atrioventricular valve over time, from its formation to the mature structure.


name: vascular associated smooth muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.


venous blood vessel development

description: The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed.


name: positive regulation of inhibitory G protein-coupled receptor phosphorylation

description: Any process that activates or increases the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation.


TSP2_HUMAN Thrombospondin-2 (sprot)

A thrombospondin-2 that is encoded in the genome of human.


TSP4_HUMAN Thrombospondin-4 (sprot)

A thrombospondin-4 that is encoded in the genome of human.


name: HXD12_HUMAN Homeobox protein Hox-D12 (sprot)

description: A homeobox protein Hox-D12 that is encoded in the genome of human.


name: HXD13_HUMAN Homeobox protein Hox-D13 (sprot)

description: A homeobox protein Hox-D13 that is encoded in the genome of human.


branch elongation of an epithelium

description: The growth process in which a branch increases in length from its base to its tip.


name: DRD3_HUMAN D(3) dopamine receptor (sprot)

description: A D(3) dopamine receptor that is encoded in the genome of human.


name: musculoskeletal movement, spinal reflex action

description: Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord.


name: positive regulation of dopamine receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the dopamine receptor protein signaling pathway. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.


IDUA_HUMAN Alpha-L-iduronidase (sprot)

An alpha-L-iduronidase that is encoded in the genome of human.


heparin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.


L-iduronidase activity

description: Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate.


disaccharide metabolic process

description: The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units.


name: SCN1A_HUMAN Sodium channel protein type 1 subunit alpha (sprot)

description: A sodium channel protein type 1 subunit alpha that is encoded in the genome of human.


name: membrane depolarization during action potential

description: The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


name: SCN4A_HUMAN Sodium channel protein type 4 subunit alpha (sprot)

description: A sodium channel protein type 4 subunit alpha that is encoded in the genome of human.


name: regulation of skeletal muscle contraction by action potential

description: Any action potential process that regulates skeletal muscle contraction.


name: UD13_HUMAN UDP-glucuronosyltransferase 1A3 (sprot)

description: A UDP-glucuronosyltransferase 1A3 that is encoded in the genome of human.


name: UD15_HUMAN UDP-glucuronosyltransferase 1A5 (sprot)

description: A UDP-glucuronosyltransferase 1A5 that is encoded in the genome of human.


name: CBS_HUMAN Cystathionine beta-synthase (sprot)

description: A cystathionine beta-synthase that is encoded in the genome of human.


cystathionine beta-synthase activity

description: Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.


carbon monoxide binding

description: Binding to carbon monoxide (CO).


S-adenosyl-L-methionine binding

description: Binding to S-adenosyl-L-methionine.


DNA protection

description: Any process in which DNA is protected from damage by, for example, oxidative stress.


homocysteine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid.


name: CLCN1_HUMAN Chloride channel protein 1 (sprot)

description: A chloride channel protein, skeletal muscle that is encoded in the genome of human.


voltage-gated chloride channel activity

description: Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: K1C9_HUMAN Keratin, type I cytoskeletal 9 (sprot)

description: A keratin, type I cytoskeletal 9 that is encoded in the genome of human.


name: SAA4_HUMAN Serum amyloid A-4 protein (sprot)

description: A primate-type serum amyloid A-4 protein that is encoded in the genome of human.


name: MSX2_HUMAN Homeobox protein MSX-2 (sprot)

description: A homeobox protein MSX-2 that is encoded in the genome of human.


FBN1_HUMAN Fibrillin-1 (sprot)

A fibrillin-1 that is encoded in the genome of human.


name: sequestering of TGFbeta in extracellular matrix

description: Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins.


post-embryonic eye morphogenesis

description: The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight.


FBN2_HUMAN Fibrillin-2 (sprot)

A fibrillin-2 that is encoded in the genome of human.


HXK4_HUMAN Hexokinase-4 (sprot)

A hexokinase-4 that is encoded in the genome of human.


glucose sensor activity

description: Binding to and responding, e.g. by conformational change, to changes in the cellular level of glucose.


name: PCKGC_HUMAN Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (sprot)

description: A phosphoenolpyruvate carboxykinase, cytosolic [GTP] that is encoded in the genome of human.


name: phosphoenolpyruvate carboxykinase (GTP) activity

description: Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.


name: protein serine kinase activity (using GTP as donor)

description: Catalysis of the reactions: GTP + L-seryl-[protein] = GDP + H+ + O-phospho-L-seryl-[protein].


name: glycerol biosynthetic process from pyruvate

description: The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate.


name: regulation of lipid biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.


name: cellular response to potassium ion starvation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of potassium ions.


response to interleukin-6

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.


response to methionine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus.


name: IRS1_HUMAN Insulin receptor substrate 1 (sprot)

description: An insulin receptor substrate 1 that is encoded in the genome of human.


name: GDE_HUMAN Glycogen debranching enzyme (sprot)

description: A glycogen debranching enzyme that is encoded in the genome of human.


glycogen debranching enzyme activity

description: Catalysis of the cleavage of branch points in branched glycogen polymers.


4-alpha-glucanotransferase activity

description: Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan.


amylo-alpha-1,6-glucosidase activity

description: Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present.


description: Catalysis of the reaction: beta-D-glucose + a plant soluble heteroglycan = a plant soluble heteroglycan + maltose.


isoamylase complex

description: A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages.


name: G6PC1_HUMAN Glucose-6-phosphatase catalytic subunit 1 (sprot)

description: A glucose-6-phosphatase catalytic subunit 1 that is encoded in the genome of human.


glucose-6-phosphatase activity

description: Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate.


MYH9_HUMAN Myosin-9 (sprot)

A myosin-9 that is encoded in the genome of human.


actomyosin structure organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.


cytokinetic process

description: A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).


name: establishment of meiotic spindle localization

description: The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs.


cortical granule exocytosis

description: The process of secretion by a cell that results in the release of intracellular molecules contained within a cortical granule by fusion of the vesicle with the plasma membrane of a cell. A cortical granule is a specialized secretory vesicle that is released during egg activation that changes the surface of the egg to prevent polyspermy.


name: negative regulation of actin filament severing

description: Any process that stops, prevents or reduces the frequency, rate or extent of actin filament severing.


actomyosin contractile ring

description: A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis.


actomyosin

description: Any complex of actin, myosin, and accessory proteins.


myosin II filament

description: A bipolar filament composed of myosin II molecules.


MYH10_HUMAN Myosin-10 (sprot)

A myosin-10 that is encoded in the genome of human.


name: TIE1_HUMAN Tyrosine-protein kinase receptor Tie-1 (sprot)

description: A tyrosine-protein kinase receptor Tie-1 that is encoded in the genome of human.


name: lymphatic endothelial cell differentiation

description: The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels.


name: branching involved in lymph vessel morphogenesis

description: The process of the coordinated growth and sprouting of lymph vessels giving rise to the organized lymphatic system.


name: COPB2_HUMAN Coatomer subunit beta' (sprot)

description: A coatomer subunit beta' that is encoded in the genome of human.


ACTN2_HUMAN Alpha-actinin-2 (sprot)

An alpha-actinin-2 that is encoded in the genome of human.


actin filament uncapping

description: The removal of capping protein from the end of actin filaments to free the ends for addition, exchange or removal of further actin subunits.


name: positive regulation of endocytic recycling

description: Any process that activates or increases the frequency, rate or extent of endocytic recycling.


name: SOAT1_HUMAN Sterol O-acyltransferase 1 (sprot)

description: A sterol O-acyltransferase 1 that is encoded in the genome of human.


name: positive regulation of amyloid precursor protein biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.


ADDA_HUMAN Alpha-adducin (sprot)

An alpha-adducin that is encoded in the genome of human.


name: positive regulation of adherens junction organization

description: Any process that activates or increases the frequency, rate or extent of adherens junction organization.


F-actin capping protein complex

description: A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.


ADDB_HUMAN Beta-adducin (sprot)

A beta-adducin that is encoded in the genome of human.


BASI_HUMAN Basigin (sprot)

A basigin that is encoded in the genome of human.


name: TIMP3_HUMAN Metalloproteinase inhibitor 3 (sprot)

description: A metalloproteinase inhibitor 3 that is encoded in the genome of human.


name: ARBK2_HUMAN G protein-coupled receptor kinase 3 (sprot)

description: A G protein-coupled receptor kinase 3 that is encoded in the genome of human.


name: FUS_HUMAN RNA-binding protein FUS (sprot)

description: An RNA-binding protein FUS that is encoded in the genome of human.


name: DDIT3_HUMAN DNA damage-inducible transcript 3 protein (sprot)

description: A DNA damage-inducible transcript 3 protein that is encoded in the genome of human.


name: intrinsic apoptotic signaling pathway in response to nitrosative stress

description: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to nitrosative stress; a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.


name: negative regulation of determination of dorsal identity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of determination of dorsal identity.


name: NU214_HUMAN Nuclear pore complex protein Nup214 (sprot)

description: A nuclear pore complex protein Nup214 that is encoded in the genome of human.


cytoplasmic side of nuclear pore

description: The side of the nuclear pore complex (NPC) that faces the cytoplasm.


DEK_HUMAN Protein DEK (sprot)

A protein DEK that is encoded in the genome of human.


CYLC1_HUMAN Cylicin-1 (sprot)

A cylicin-1 that is encoded in the genome of human.


cytoskeletal calyx

description: A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins.


name: ATP7B_HUMAN Copper-transporting ATPase 2 (sprot)

description: A copper-transporting ATPase 2 that is encoded in the genome of human.


name: P-type divalent copper transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out).


name: P-type monovalent copper transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu+(in) = ADP + phosphate + Cu+(out).


name: HNF1B_HUMAN Hepatocyte nuclear factor 1-beta (sprot)

description: A hepatocyte nuclear factor 1-beta that is encoded in the genome of human.


endodermal cell fate specification

description: The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.