name: MMP20_HUMAN Matrix metalloproteinase-20 (sprot)

description: A matrix metalloproteinase-20 that is encoded in the genome of human.


regulation of enamel mineralization

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel.


name: G37L1_HUMAN G-protein coupled receptor 37-like 1 (sprot)

description: A G-protein coupled receptor 37-like 1 that is encoded in the genome of human.


name: positive regulation of cerebellar granule cell precursor proliferation

description: The process that activates or increases the rate or extent of granule cell precursor proliferation.


name: negative regulation of astrocyte differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation.


name: DNJA2_HUMAN DnaJ homolog subfamily A member 2 (sprot)

description: A DnaJ homolog subfamily A member 2 that is encoded in the genome of human.


protein refolding

description: The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.


name: BRD4_HUMAN Bromodomain-containing protein 4 (sprot)

description: A bromodomain-containing protein 4 that is encoded in the genome of human.


name: RNA polymerase II CTD heptapeptide repeat kinase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.


name: RNA polymerase II C-terminal domain binding

description: Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function.


P-TEFb complex binding

description: Binding to a P-TEFb complex.


CUTA_HUMAN Protein CutA (sprot)

A protein CutA that is encoded in the genome of human.


response to metal ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.


OPHN1_HUMAN Oligophrenin-1 (sprot)

An oligophrenin-1 that is encoded in the genome of human.


cerebral cortex neuron differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.


name: regulation of Rho protein signal transduction

description: Any process that modulates the frequency, rate or extent of Rho protein signal transduction.


name: cell morphogenesis involved in neuron differentiation

description: The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.


name: maintenance of postsynaptic specialization structure

description: A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.


name: RAMP1_HUMAN Receptor activity-modifying protein 1 (sprot)

description: A receptor activity-modifying protein 1 that is encoded in the genome of human.


name: calcitonin gene-related peptide receptor activity

description: Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity.


amylin receptor activity

description: Combining with amylin to initiate a change in cell activity.


calcitonin gene-related peptide binding

description: Binding to calcitonin gene-related peptide (CGRP).


receptor internalization

description: A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.


name: positive regulation of protein glycosylation

description: Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.


amylin receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A G protein-coupled receptor signaling pathway initiated by amylin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


name: calcitonin gene-related peptide receptor signaling pathway

description: The series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers.


CGRP receptor complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A transmembrane, G protein-coupled signaling receptor complex recognized by calcitonin gene-related peptides (CGRP).


name: RAMP2_HUMAN Receptor activity-modifying protein 2 (sprot)

description: A receptor activity-modifying protein 2 that is encoded in the genome of human.


adrenomedullin receptor activity

description: Combining with adrenomedullin to initiate a change in cell activity.


adrenomedullin binding

description: Binding to adrenomedullin (AM).


vasculogenesis

description: The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.


name: vascular associated smooth muscle cell development

description: The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.


name: adrenomedullin receptor signaling pathway

description: The series of molecular signals initiated by an extracellular adrenomedullin combining with a dimeric adrenomedullin receptor on the surface of the target cell.


positive regulation of vasculogenesis

description: Any process that activates or increases the frequency, rate or extent of vasculogenesis.


adrenomedullin receptor complex

description: A transmembrane, G protein-coupled signaling receptor complex which is capable of adrenomedullin receptor activity.


name: RAMP3_HUMAN Receptor activity-modifying protein 3 (sprot)

description: A receptor activity-modifying protein 3 that is encoded in the genome of human.


name: positive regulation of protein kinase A signaling

description: Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.


name: cross-receptor inhibition within G protein-coupled receptor heterodimer

description: Inhibition of one protomer of a G protein-coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit.


name: positive regulation of calcium-mediated signaling

description: Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.


name: G protein-coupled receptor signaling pathway involved in heart process

description: An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart.


amylin receptor complex 3

description: A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 3. Amylin receptor complex 3 (AMY3) also serves as a receptor for the amyloid-beta complex. Ligand binding to AMY3 results in increased cytosolic calcium ion levels and in activation on multiple intracellular signaling pathways.


name: SHOX2_HUMAN Short stature homeobox protein 2 (sprot)

description: A short stature homeobox protein 2 that is encoded in the genome of human.


sinoatrial valve development

description: The progression of the sinoatrial valve over time, from its formation to the mature structure.


cardiac right atrium morphogenesis

description: The process in which the right cardiac atrium is generated and organized.


mesenchymal cell proliferation

description: The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


name: regulation of chondrocyte differentiation

description: Any process that modulates the frequency, rate or extent of chondrocyte differentiation.


name: positive regulation of skeletal muscle fiber development

description: Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.


name: cartilage development involved in endochondral bone morphogenesis

description: The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones.


cardiac pacemaker cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.


name: regulation of branching morphogenesis of a nerve

description: Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve.


name: NSMA_HUMAN Sphingomyelin phosphodiesterase 2 (sprot)

description: A sphingomyelin phosphodiesterase 2 that is encoded in the genome of human.


description: Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+.


phosphoric diester hydrolase activity

description: Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.


sphingomyelin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.


name: TBL1X_HUMAN F-box-like/WD repeat-containing protein TBL1X (sprot)

description: An F-box-like/WD repeat-containing protein TBL1X that is encoded in the genome of human.


name: B4GT2_HUMAN Beta-1,4-galactosyltransferase 2 (sprot)

description: A beta-1,4-galactosyltransferase 2 that is encoded in the genome of human.


lactose synthase activity

description: Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose.


CATL2_HUMAN Cathepsin L2 (sprot)

A cathepsin L2 that is encoded in the genome of human.


name: antigen processing and presentation of exogenous peptide antigen via MHC class II

description: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.


name: HUS1_HUMAN Checkpoint protein HUS1 (sprot)

description: A checkpoint protein HUS1 that is encoded in the genome of human.


PFD1_HUMAN Prefoldin subunit 1 (sprot)

A prefoldin subunit 1 that is encoded in the genome of human.


name: PP1RB_HUMAN E3 ubiquitin-protein ligase PPP1R11 (sprot)

description: An E3 ubiquitin-protein ligase PPP1R11 that is encoded in the genome of human.


name: KCJ13_HUMAN Inward rectifier potassium channel 13 (sprot)

description: An inward rectifier potassium channel 13 that is encoded in the genome of human.


RNH1_HUMAN Ribonuclease H1 (sprot)

A ribonuclease H1 that is encoded in the genome of human.


RNA-DNA hybrid ribonuclease activity

description: Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.


CTNS_HUMAN Cystinosin (sprot)

A cystinosin that is encoded in the genome of human.


name: L-cystine transmembrane transporter activity

description: Enables the transfer of L-cystine from one side of a membrane to the other.


name: solute:proton symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in).


amino acid metabolic process

description: The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.


grooming behavior

description: The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.


name: negative regulation of hydrogen peroxide biosynthetic process

description: Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.


name: positive regulation of mitochondrial membrane potential

description: Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


L-cystine transport

description: The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


renal glucose absorption

description: A renal system process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.


melanin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.


name: regulation of melanin biosynthetic process

description: Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin.


renal water absorption

description: A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.


proximal tubule morphogenesis

description: The process in which the anatomical structures of a proximal tubule are generated and organized. The proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology.


renal albumin absorption

description: A renal system process in which albumin is taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron.


brush border assembly

description: The aggregation, arrangement and bonding together of adjacent microvilli through the formation of Ca(2+)-dependent adhesion links between them, forming a brush border.


name: positive regulation of thyroid hormone generation

description: Any process that activates or increases the frequency, rate or extent of thyroid hormone generation.


melanosome membrane

description: The lipid bilayer surrounding a melanosome.


NBN_HUMAN Nibrin (sprot)

A nibrin that is encoded in the genome of human.


description: Binding to a protein upon phosphorylation of the target protein.


DNA double-strand break processing

description: The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang.


name: protection from non-homologous end joining at telomere

description: A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse.


telomeric 3' overhang formation

description: The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans.


name: positive regulation of telomere maintenance

description: Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.


positive regulation of kinase activity

description: Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


homologous recombination

description: A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules.


name: telomere maintenance in response to DNA damage

description: Any process that occur in response to the presence of critically short or damaged telomeres.


isotype switching

description: The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.


R-loop processing

description: A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability.


name: double-strand break repair via alternative nonhomologous end joining

description: An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment.


name: DNA strand resection involved in replication fork processing

description: The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing.


negative regulation of telomere capping

description: Any process that stops, prevents or reduces the frequency, rate or extent of telomere capping.


Mre11 complex

description: Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.


nuclear inclusion body

description: An intranuclear focus at which aggregated proteins have been sequestered.


BRCA1-C complex

description: A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint.


chromosomal region

description: Any subdivision of a chromosome along its length.


NOL3_HUMAN Nucleolar protein 3 (sprot)

A nucleolar protein 3 that is encoded in the genome of human.


mRNA splice site recognition

description: Selection of a splice site by components of the assembling spliceosome.


negative regulation of muscle atrophy

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle atrophy.


name: release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

description: The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.


name: response to injury involved in regulation of muscle adaptation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a injury. This process occurs as part of the regulation of muscle adaptation.


name: regulation of non-canonical NF-kappaB signal transduction

description: Any process that modulates the frequency, rate or extent of the non-canonical NF-kappaB signaling cascade.


name: negative regulation of mitochondrial membrane permeability involved in apoptotic process

description: Any negative regulation of mitochondrial membrane permeability that is involved in apoptotic process.


name: negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway.


name: inhibition of cysteine-type endopeptidase activity involved in apoptotic process

description: Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process.


KERA_HUMAN Keratocan (sprot)

A keratocan that is encoded in the genome of human.


name: SCN2B_HUMAN Sodium channel subunit beta-2 (sprot)

description: A sodium channel subunit beta-2 that is encoded in the genome of human.


name: voltage-gated sodium channel activity involved in cardiac muscle cell action potential

description: Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

description: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


response to pyrethroid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage.


name: membrane depolarization during cardiac muscle cell action potential

description: The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


name: membrane repolarization during ventricular cardiac muscle cell action potential

description: The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.


voltage-gated sodium channel complex

description: A sodium channel in a cell membrane whose opening is governed by the membrane potential.


DTNB_HUMAN Dystrobrevin beta (sprot)

A dystrobrevin beta that is encoded in the genome of human.


inhibitory synapse

description: A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell.


MCE1_HUMAN mRNA-capping enzyme (sprot)

An mRNA-capping enzyme that is encoded in the genome of human.


mRNA guanylyltransferase activity

description: Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue.


polynucleotide 5'-phosphatase activity

description: Catalysis of the reaction: a 5'-phosphopolynucleotide + H2O = a polynucleotide + phosphate.


phosphoprotein phosphatase activity

description: Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.


RNA guanylyltransferase activity

description: Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule.


name: inorganic triphosphate phosphatase activity

description: Catalysis of the reaction: H2O + inorganic triphosphate = diphosphate + phosphate.


name: mRNA 5'-triphosphate monophosphatase activity

description: A 5'-end triphospho-[mRNA] + H2O = a 5'-end diphospho-[mRNA] + H+ + phosphate.


name: ENK19_HUMAN Endogenous retrovirus group K member 19 Env polyprotein (sprot)


name: syncytium formation by plasma membrane fusion

description: The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.


name: FCG3B_HUMAN Low affinity immunoglobulin gamma Fc region receptor III-B (sprot)

description: A low affinity immunoglobulin gamma Fc region receptor III-B that is encoded in the genome of human.


IgG binding

description: Binding to an immunoglobulin of an IgG isotype.


Fc-gamma receptor signaling pathway

description: The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.


name: LIRA1_HUMAN Leukocyte immunoglobulin-like receptor subfamily A member 1 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily A member 1 that is encoded in the genome of human.


name: LIRB3_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 3 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily B member 3 that is encoded in the genome of human.


name: LIRB5_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 5 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily B member 5 that is encoded in the genome of human.


name: ABCB7_HUMAN Iron-sulfur clusters transporter ABCB7, mitochondrial (sprot)

description: An iron-sulfur clusters transporter ABCB7, mitochondrial that is encoded in the genome of human.


name: ABC-type iron-sulfur cluster transporter activity

description: Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out).


intracellular iron ion homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell.


iron ion transmembrane transport

description: A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.


name: positive regulation of heme biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme.


name: iron-sulfur cluster export from the mitochondrion

description: The directed movement of iron sulfur clusters from inside the mitochondrion into the cytosol by crossing the inner mitochondrial membrane.


name: positive regulation of iron-sulfur cluster assembly

description: Any process that activates or increases the frequency, rate or extent of iron-sulfur cluster assembly.


name: MITF_HUMAN Microphthalmia-associated transcription factor (sprot)

description: A microphthalmia-associated transcription factor that is encoded in the genome of human.


melanocyte differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.


camera-type eye development

description: The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.


name: regulation of osteoclast differentiation

description: Any process that modulates the frequency, rate or extent of osteoclast differentiation.


melanocyte apoptotic process

description: Any apoptotic process in a melanocyte, the main structural component of the epidermis.


name: positive regulation of DNA-templated transcription initiation

description: Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation.


regulation of RNA biosynthetic process

description: Any process that modulates the frequency, rate or extent of RNA biosynthetic process.


name: HSF2B_HUMAN Heat shock factor 2-binding protein (sprot)

description: A heat shock factor 2-binding protein that is encoded in the genome of human.


name: double-strand break repair involved in meiotic recombination

description: The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination.


name: KI21B_HUMAN Kinesin-like protein KIF21B (sprot)

description: A kinesin-like protein KIF21B that is encoded in the genome of human.


name: PLCH2_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (sprot)

description: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 that is encoded in the genome of human.


name: SRGP2_HUMAN SLIT-ROBO Rho GTPase-activating protein 2 (sprot)

description: A SLIT-ROBO Rho GTPase-activating protein 2 that is encoded in the genome of human.


name: lamellipodium assembly involved in ameboidal cell migration

description: Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell.


name: extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

description: The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells.


actin filament severing

description: The process in which an actin filament is broken down into smaller filaments.


negative regulation of neuron migration

description: Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.


dendritic spine head

description: Distal part of the dendritic spine, that carries the post-synaptic density.


PLXA2_HUMAN Plexin-A2 (sprot)

A plexin-A2 that is encoded in the genome of human.


name: cerebellar granule cell precursor tangential migration

description: The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium.


name: CAPON_HUMAN Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (sprot)

description: A carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein that is encoded in the genome of human.


name: regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

description: Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel.


name: positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential

description: Any process that activates or increases the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential.


name: nitric-oxide synthase regulator activity

description: Binds to and modulates the activity of nitric oxide synthase.


nitric-oxide synthase binding

description: Binding to nitric-oxide synthase.


name: regulation of heart rate by chemical signal

description: The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine.


name: regulation of nitric-oxide synthase activity

description: Any process that modulates the activity of the enzyme nitric-oxide synthase.


name: regulation of ventricular cardiac muscle cell membrane repolarization

description: Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.


name: regulation of cardiac muscle cell action potential

description: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


name: regulation of high voltage-gated calcium channel activity

description: Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity.


name: positive regulation of peptidyl-cysteine S-nitrosylation

description: Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.


name: IGSF3_HUMAN Immunoglobulin superfamily member 3 (sprot)

description: An immunoglobulin superfamily member 3 that is encoded in the genome of human.


SDC3_HUMAN Syndecan-3 (sprot)

A syndecan-3 that is encoded in the genome of human.


microspike

description: A dynamic, actin-rich projection extending from the surface of a migrating animal cell.


AUXI_HUMAN Auxilin (sprot)

A putative tyrosine-protein phosphatase auxilin that is encoded in the genome of human.


name: extrinsic component of presynaptic endocytic zone membrane

description: The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


name: XYLK_HUMAN Glycosaminoglycan xylosylkinase (sprot)

description: A glycosaminoglycan xylosylkinase that is encoded in the genome of human.


name: phosphotransferase activity, alcohol group as acceptor

description: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).


name: DEN4B_HUMAN DENN domain-containing protein 4B (sprot)

description: A DENN domain-containing protein 4B that is encoded in the genome of human.


name: regulation of Rab protein signal transduction

description: Any process that modulates the frequency, rate or extent of Rab protein signal transduction.


name: TMCC2_HUMAN Transmembrane and coiled-coil domains protein 2 (sprot)

description: A transmembrane and coiled-coil domains protein 2 that is encoded in the genome of human.


name: amyloid precursor protein metabolic process

description: The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.


name: EFC14_HUMAN EF-hand calcium-binding domain-containing protein 14 (sprot)

description: An EF-hand calcium-binding domain-containing protein 14 that is encoded in the genome of human.


name: FKTN_HUMAN Ribitol-5-phosphate transferase FKTN (sprot)

description: A ribitol-5-phosphate transferase FKTN that is encoded in the genome of human.


name: phosphotransferase activity, for other substituted phosphate groups

description: Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor).


regulation of protein glycosylation

description: Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.


name: LRP3_HUMAN Low-density lipoprotein receptor-related protein 3 (sprot)

description: A low-density lipoprotein receptor-related protein 3 that is encoded in the genome of human.


name: ADA23_HUMAN Disintegrin and metalloproteinase domain-containing protein 23 (sprot)

description: A disintegrin and metalloproteinase domain-containing protein 23 that is encoded in the genome of human.


name: ADA11_HUMAN Disintegrin and metalloproteinase domain-containing protein 11 (sprot)

description: A disintegrin and metalloproteinase domain-containing protein 11 that is encoded in the genome of human.


name: multicellular organismal response to stress

description: Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


name: behavioral response to acetic acid induced pain

description: Any process that results in a change in the behaviour of an organism as a result of an acetic acid pain stimulus.


name: behavioral response to formalin induced pain

description: Any process that results in a change in the behaviour of an organism as a result of a formalin pain stimulus.


MTG16_HUMAN Protein CBFA2T3 (sprot)

A protein CBFA2T3 that is encoded in the genome of human.


regulation of aerobic respiration

description: Any process that modulates the frequency, rate or extent of aerobic respiration.


name: WDR1_HUMAN WD repeat-containing protein 1 (sprot)

description: A WD repeat-containing protein 1 that is encoded in the genome of human.


neutrophil mediated immunity

description: Any process involved in the carrying out of an immune response by a neutrophil.


actin filament fragmentation

description: The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins.


platelet formation

description: The process in which platelets bud from long processes extended by megakaryocytes.


name: regulation of actin filament depolymerization

description: Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament.


name: positive regulation of actin filament depolymerization

description: Any process that activates or increases the frequency, rate or extent of actin depolymerization.


cortical cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.


name: establishment of planar polarity of follicular epithelium

description: Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates.


apical junction assembly

description: The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents.


neutrophil migration

description: The movement of a neutrophil within or between different tissues and organs of the body.


FZD7_HUMAN Frizzled-7 (sprot)

A frizzled-7 that is encoded in the genome of human.


name: negative regulation of ectodermal cell fate specification

description: Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell.


mesenchymal to epithelial transition

description: A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell.


name: SLIT1_HUMAN Slit homolog 1 protein (sprot)

description: A slit homolog 1 protein that is encoded in the genome of human.


dorsal/ventral axon guidance

description: The process in which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.


forebrain morphogenesis

description: The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).


name: SLIT3_HUMAN Slit homolog 3 protein (sprot)

description: A slit homolog 3 protein that is encoded in the genome of human.


Roundabout signaling pathway

description: The series of molecular signals initiated by a SLIT protein binding to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


response to cortisol

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.


name: apoptotic process involved in luteolysis

description: The apoptotic process that contributes to luteolysis.


name: MEGF6_HUMAN Multiple epidermal growth factor-like domains protein 6 (sprot)

description: A multiple epidermal growth factor-like domains protein 6 that is encoded in the genome of human.


name: LRP4_HUMAN Low-density lipoprotein receptor-related protein 4 (sprot)

description: A low-density lipoprotein receptor-related protein 4 that is encoded in the genome of human.


apolipoprotein binding

description: Binding to an apolipoprotein, the protein component of a lipoprotein complex.


name: positive regulation of Rac protein signal transduction

description: Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction.


negative regulation of axonogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis.


name: synaptic assembly at neuromuscular junction

description: The assembly of a synapse at a neuromuscular junction.


postsynaptic membrane assembly

description: The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).


presynaptic membrane assembly

description: The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.


name: amyloid-beta clearance by cellular catabolic process

description: The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation.


name: positive regulation of presynaptic membrane organization

description: Any process that activates or increases the frequency, rate or extent of presynaptic membrane organization.


name: positive regulation of skeletal muscle acetylcholine-gated channel clustering

description: Any process that activates or increases the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering.


plasma membrane raft

description: A membrane raft that is part of the plasma membrane.


name: AOC2_HUMAN Amine oxidase [copper-containing] 2 (sprot)

description: A retina-specific copper amine oxidase that is encoded in the genome of human.


primary amine oxidase activity

description: Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide.


quinone binding

description: Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.


aliphatic amine oxidase activity

description: Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+.


catecholamine metabolic process

description: The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.


name: ATP9A_HUMAN Probable phospholipid-transporting ATPase IIA (sprot)

description: A probable phospholipid-transporting ATPase IIA that is encoded in the genome of human.


regulation of endocytic recycling

description: Any process that modulates the frequency, rate or extent of endocytic recycling.


name: LDB3_HUMAN LIM domain-binding protein 3 (sprot)

description: A LIM domain-binding protein 3 that is encoded in the genome of human.


name: N4BP1_HUMAN NEDD4-binding protein 1 (sprot)

description: A NEDD4-binding protein 1 that is encoded in the genome of human.


regulation of innate immune response

description: Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.


name: ROCK2_HUMAN Rho-associated protein kinase 2 (sprot)

description: A Rho-associated protein kinase 2 that is encoded in the genome of human.


tau-protein kinase activity

description: Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.


name: Rho-dependent protein serine/threonine kinase activity

description: Rho GTPase-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


name: positive regulation of cardiac muscle hypertrophy

description: Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.


name: positive regulation of centrosome duplication

description: Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.


regulation of nervous system process

description: Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.


name: positive regulation of connective tissue growth factor production

description: Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production.


name: negative regulation of nitric oxide biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.


name: regulation of keratinocyte differentiation

description: Any process that modulates the frequency, rate or extent of keratinocyte differentiation.


mRNA destabilization

description: Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.


name: negative regulation of biomineral tissue development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.


name: cellular response to testosterone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.


name: response to transforming growth factor beta

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.


name: positive regulation of fibroblast growth factor production

description: Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


name: regulation of angiotensin-activated signaling pathway

description: Any process that modulates the frequency, rate or extent of the angiotensin-activated signaling pathway.


name: negative regulation of protein localization to lysosome

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome.


name: regulation of cellular response to hypoxia

description: Any process that modulates the frequency, rate or extent of cellular response to hypoxia.


name: positive regulation of protein localization to early endosome

description: Any process that activates or increases the frequency, rate or extent of protein localization to early endosome.


name: positive regulation of amyloid precursor protein catabolic process

description: Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process.


cellular response to acetylcholine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus.


name: positive regulation of connective tissue replacement

description: Any process that activates or increases the frequency, rate or extent of connective tissue replacement.


response to angiotensin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.


name: MFA3L_HUMAN Microfibrillar-associated protein 3-like (sprot)

description: A microfibrillar-associated protein 3-like that is encoded in the genome of human.


name: CLAP2_HUMAN CLIP-associating protein 2 (sprot)

description: A CLIP-associating protein 2 that is encoded in the genome of human.


microtubule plus-end binding

description: Binding to the plus end of a microtubule.


regulation of gastrulation

description: Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.


name: microtubule organizing center organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.


name: regulation of microtubule polymerization or depolymerization

description: Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.


name: positive regulation of extracellular matrix disassembly

description: Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.


presynaptic cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton.


name: positive regulation of basement membrane assembly involved in embryonic body morphogenesis

description: Any process that activates or increases the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis.


basal cortex

description: The region that lies just beneath the plasma membrane on the basal edge of a cell.


name: ZN623_HUMAN Zinc finger protein 623 (sprot)

description: A zinc finger protein 623 that is encoded in the genome of human.


name: PTCD1_HUMAN Pentatricopeptide repeat-containing protein 1, mitochondrial (sprot)

description: A pentatricopeptide repeat-containing protein 1 that is encoded in the genome of human.


tRNA 3'-end processing

description: The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA.


COBL_HUMAN Protein cordon-bleu (sprot)

A protein cordon-bleu that is encoded in the genome of human.


floor plate development

description: The progression of the floor plate over time from its initial formation until its mature state.


name: collateral sprouting in absence of injury

description: The process in which outgrowths develop from the axons of intact undamaged neurons.


actin filament network formation

description: The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments.


name: positive regulation of dendrite development

description: Any process that activates or increases the frequency, rate or extent of dendrite development.


positive regulation of ruffle assembly

description: Any process that activates or increases the frequency, rate or extent of ruffle assembly.


dendritic growth cone

description: The migrating motile tip of a growing nerve cell dendrite.


ASTN2_HUMAN Astrotactin-2 (sprot)

An astrotactin-2 that is encoded in the genome of human.


name: inositol 1,3,4,5 tetrakisphosphate binding

description: Binding to inositol 1,3,4,5 tetrakisphosphate.


cell pole

description: Either of two different areas at opposite ends of an axis of a cell.


CPNE3_HUMAN Copine-3 (sprot)

A copine-3 that is encoded in the genome of human.


ERBB2 signaling pathway

description: The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.


name: ZBED4_HUMAN Zinc finger BED domain-containing protein 4 (sprot)

description: A zinc finger BED domain-containing protein 4 that is encoded in the genome of human.


name: DEPD5_HUMAN GATOR1 complex protein DEPDC5 (sprot)

description: A GATOR1 complex protein DEPDC5 that is encoded in the genome of human.


GATOR1 complex

description: A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.


name: ATG13_HUMAN Autophagy-related protein 13 (sprot)

description: An autophagy-related protein 13 that is encoded in the genome of human.


name: response to mitochondrial depolarisation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria.


regulation of protein lipidation

description: Any process that modulates the frequency, rate or extent of protein lipidation.


phagophore assembly site membrane

description: A cellular membrane associated with the phagophore assembly site.


phagophore assembly site

description: Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.


Atg1/ULK1 kinase complex

description: A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.


ICOSL_HUMAN ICOS ligand (sprot)

An ICOS ligand that is encoded in the genome of human.


name: positive regulation of activated T cell proliferation

description: Any process that activates or increases the rate or extent of activated T cell proliferation.


LIPA3_HUMAN Liprin-alpha-3 (sprot)

A liprin-alpha-3 that is encoded in the genome of human.


epididymosome

description: A microvesicle of the epididymal fluid, from which spermatozoa acquire membrane proteins.


name: HIP1R_HUMAN Huntingtin-interacting protein 1-related protein (sprot)

description: A huntingtin-interacting protein 1-related protein that is encoded in the genome of human.


name: negative regulation of actin filament polymerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.


name: negative regulation of Arp2/3 complex-mediated actin nucleation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins.


digestive system development

description: The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.


name: positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

description: Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.


name: positive regulation of clathrin coat assembly

description: Any process that activates or increases the frequency, rate or extent of clathrin coat assembly.


name: OBSL1_HUMAN Obscurin-like protein 1 (sprot)

description: An obscurin-like protein 1 that is encoded in the genome of human.


3M complex

description: A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity.


name: BRE1B_HUMAN E3 ubiquitin-protein ligase BRE1B (sprot)

description: An E3 ubiquitin-protein ligase BRE1B that is encoded in the genome of human.


HULC complex

description: A ubiquitin ligase complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp6, Shf1, Brl2/Rfp1 and Brl1/Rfp2.


name: PHF2_HUMAN Lysine-specific demethylase PHF2 (sprot)

description: A lysine-specific demethylase PHF2 that is encoded in the genome of human.


histone H4K20 demethylase activity

description: Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


name: negative regulation of rDNA heterochromatin formation

description: Any process that decreases the rate, frequency, or extent of ribosomal DNA heterochromatin formation.


name: ZC11A_HUMAN Zinc finger CCCH domain-containing protein 11A (sprot)

description: A zinc finger CCCH domain-containing protein 11A that is encoded in the genome of human.


transcription export complex

description: The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.


name: CLU_HUMAN Clustered mitochondria protein homolog (sprot)

description: A clustered mitochondria protein homolog that is encoded in the genome of human.


name: RFIP3_HUMAN Rab11 family-interacting protein 3 (sprot)

description: A Rab11 family-interacting protein 3 that is encoded in the genome of human.


dynein light intermediate chain binding

description: Binding to a light intermediate chain of the dynein complex.


name: Golgi to plasma membrane protein transport

description: The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.


name: early endosome to recycling endosome transport

description: The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes.


name: negative regulation of adiponectin secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell.


name: regulation of early endosome to recycling endosome transport

description: Any process that modulates the frequency, rate or extent of early endosome to recycling endosome transport.


name: positive regulation of mitotic cytokinetic process

description: Any process that activates or increases the frequency, rate or extent of mitotic cytokinetic process.


name: regulation of protein localization to centrosome

description: Any process that modulates the frequency, rate or extent of protein localization to centrosome.


protein localization to cleavage furrow

description: A process in which a protein is transported to, or maintained in, a location within a cleavage furrow.


name: postsynaptic recycling endosome membrane

description: The lipid bilayer surrounding a postsynaptic recycling endosome.


name: CAND2_HUMAN Cullin-associated NEDD8-dissociated protein 2 (sprot)

description: A cullin-associated NEDD8-dissociated protein 2 that is encoded in the genome of human.


name: T22D2_HUMAN TSC22 domain family protein 2 (sprot)

description: A TSC22 domain family protein 2 that is encoded in the genome of human.


name: SOCS5_HUMAN Suppressor of cytokine signaling 5 (sprot)

description: A suppressor of cytokine signaling 5 that is encoded in the genome of human.


name: negative regulation of epidermal growth factor-activated receptor activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.


name: negative regulation of T-helper 2 cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.


name: negative regulation of monocyte chemotactic protein-1 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1.


name: vascular endothelial cell response to fluid shear stress

description: Any response to fluid shear stress in a vascular endothelial cell.


NPHP4_HUMAN Nephrocystin-4 (sprot)

A nephrocystin-4 that is encoded in the genome of human.


name: photoreceptor cell outer segment organization

description: A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials.


ribbon synapse

description: Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm.


photoreceptor distal connecting cilium

description: The distal region of the photoreceptor connecting cilium is structurally unique to the photoreceptor and is maintained by retina-specific protein, SPATA7, and its interacting partners RPGR and RPGRIP1. It is essential for photoreceptor sensory cilium stability.


name: KDM4A_HUMAN Lysine-specific demethylase 4A (sprot)

description: A lysine-specific demethylase 4A that is encoded in the genome of human.


histone H3K36 demethylase activity

description: Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


name: histone H3K36me2/H3K36me3 demethylase activity

description: Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


apoptotic chromosome condensation

description: The compaction of chromatin during apoptosis.


response to nutrient levels

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.


name: DJC13_HUMAN DnaJ homolog subfamily C member 13 (sprot)

description: A DnaJ homolog subfamily C member 13 that is encoded in the genome of human.


name: regulation of early endosome to late endosome transport

description: Any process that modulates the frequency, rate or extent of early endosome to late endosome transport.


name: PHAR2_HUMAN Phosphatase and actin regulator 2 (sprot)

description: A phosphatase and actin regulator 2 that is encoded in the genome of human.


name: PP6R2_HUMAN Serine/threonine-protein phosphatase 6 regulatory subunit 2 (sprot)

description: A serine/threonine-protein phosphatase 6 regulatory subunit 2 that is encoded in the genome of human.


name: ATS4_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 4 (sprot)

description: An a disintegrin and metalloproteinase with thrombospondin motifs 4 that is encoded in the genome of human.


name: CNOT3_HUMAN CCR4-NOT transcription complex subunit 3 (sprot)

description: A CCR4-NOT transcription complex subunit 3 that is encoded in the genome of human.


name: regulatory ncRNA-mediated gene silencing

description: A process in which an regulatory non-coding RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.


name: CREST_HUMAN Calcium-responsive transactivator (sprot)

description: A calcium-responsive transactivator that is encoded in the genome of human.


name: ANR17_HUMAN Ankyrin repeat domain-containing protein 17 (sprot)

description: An ankyrin repeat domain-containing protein 17 that is encoded in the genome of human.


blood vessel maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.


name: positive regulation of MDA-5 signaling pathway

description: Any process that activates or increases the frequency, rate or extent of MDA-5 signaling pathway.


name: positive regulation of RIG-I signaling pathway

description: Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway.


name: SIN3B_HUMAN Paired amphipathic helix protein Sin3b (sprot)

description: A paired amphipathic helix protein Sin3b that is encoded in the genome of human.


X chromosome

description: The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.


Y chromosome

description: The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males.


autosome

description: Any chromosome other than a sex chromosome.


name: AT2C2_HUMAN Calcium-transporting ATPase type 2C member 2 (sprot)

description: A calcium-transporting ATPase type 2C member 2 that is encoded in the genome of human.


P-type manganese transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate.


manganese ion transmembrane transport

description: A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.


name: DNJB6_HUMAN DnaJ homolog subfamily B member 6 (sprot)

description: A DnaJ homolog subfamily B member 6 that is encoded in the genome of human.


intermediate filament organization

description: Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.


name: syncytiotrophoblast cell differentiation involved in labyrinthine layer development

description: The process in which a chorionic trophoblast cell acquires specialized features of a syncytiotrophoblast of the labyrinthine layer of the placenta.


chorion development

description: The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane.


name: negative regulation of inclusion body assembly

description: Any process that decreases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body.


regulation of cellular response to heat

description: Any process that modulates the frequency, rate or extent of cellular response to heat.


XYLB_HUMAN Xylulose kinase (sprot)

A xylulose kinase that is encoded in the genome of human.


D-xylulokinase activity

description: Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H+.


xylulose metabolic process

description: The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose.


xylulose catabolic process

description: The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose.


name: glucuronate catabolic process to xylulose 5-phosphate

description: The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate.


D-xylose metabolic process

description: The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide.


name: PX11A_HUMAN Peroxisomal membrane protein 11A (sprot)

description: A peroxisomal membrane protein 11A that is encoded in the genome of human.


peroxisome membrane biogenesis

description: The process in which a peroxisome membrane is synthesized, aggregates, and bonds together.


regulation of peroxisome size

description: Any process that modulates the volume of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.


name: LRP5_HUMAN Low-density lipoprotein receptor-related protein 5 (sprot)

description: A low-density lipoprotein receptor-related protein 5 that is encoded in the genome of human.


amino acid transport

description: The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


mesodermal cell migration

description: The orderly movement of mesodermal cells from one site to another.


extracellular matrix-cell signaling

description: Any process that mediates the transfer of information between the extracellular matrix and a cell.


cell migration involved in gastrulation

description: The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).


bone marrow development

description: The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure.


anatomical structure regression

description: The developmental process in which an anatomical structure is destroyed as a part of its normal progression.


name: cell-cell signaling involved in mammary gland development

description: Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure.


name: regulation of insulin secretion involved in cellular response to glucose stimulus

description: Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.


retinal blood vessel morphogenesis

description: The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure.


Norrin signaling pathway

description: The series of molecular signals initiated by binding of the cysteine knot protein Norrin to a Frizzled 4 (Fzd4) family receptor on the surface of the target cell and ending with a change in cell state.


name: apoptotic process involved in blood vessel morphogenesis

description: Any apoptotic process that is involved in blood vessel morphogenesis.


Wnt-Frizzled-LRP5/6 complex

description: A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6.


name: NPIB7_HUMAN Nuclear pore complex-interacting protein family member B7 (sprot)

description: A nuclear pore complex-interacting protein family member B7 that is encoded in the genome of human.


name: TM127_HUMAN Transmembrane protein 127 (sprot)

description: A transmembrane protein 127 that is encoded in the genome of human.


name: COQ9_HUMAN Ubiquinone biosynthesis protein COQ9, mitochondrial (sprot)

description: A ubiquinone biosynthesis protein COQ9, mitochondrial that is encoded in the genome of human.


ubiquinone biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.


ubiquinone biosynthesis complex

description: A protein complex composed of enzymes and accessory factors of the ubiquinone (CoQ) biosynthesis pathway. In E. coli, the complex is composed of seven proteins: UbiE, F, G, H, I, J and K. In eukaryotes, the complex is located on the matrix face of the inner mitochondrial membrane and includes COQ3, COQ4, COQ5, COQ6, COQ7, COQ9.


A gamma-glutamylcyclotransferase that is encoded in the genome of human.


gamma-glutamylcyclotransferase activity

description: Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.


name: NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (sprot)

description: An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial that is encoded in the genome of human.


name: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.


name: SIM24_HUMAN Small integral membrane protein 24 (sprot)

description: A small integral membrane protein 24 that is encoded in the genome of human.


name: Z780A_HUMAN Zinc finger protein 780A (sprot)

description: A zinc finger protein 780A that is encoded in the genome of human.


name: GA45B_HUMAN Growth arrest and DNA damage-inducible protein GADD45 beta (sprot)

description: A growth arrest and DNA damage-inducible protein GADD45 beta that is encoded in the genome of human.


RTN2_HUMAN Reticulon-2 (sprot)

A reticulon-2 that is encoded in the genome of human.


regulation of glucose import

description: Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.


name: intracellular protein transmembrane transport

description: The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.


terminal cisterna

description: The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release.


name: NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (sprot)

description: An NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial that is encoded in the genome of human.


oxygen sensor activity

description: Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2).


gliogenesis

description: The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.


name: mitochondrial ATP synthesis coupled electron transport

description: The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.


neural precursor cell proliferation

description: The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.


cellular response to oxygen levels

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.


CAD16_HUMAN Cadherin-16 (sprot)

A cadherin-16 that is encoded in the genome of human.


name: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

description: The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.


name: UDB11_HUMAN UDP-glucuronosyltransferase 2B11 (sprot)

description: A UDP-glucuronosyltransferase 2B11 that is encoded in the genome of human.


name: GLRA3_HUMAN Glycine receptor subunit alpha-3 (sprot)

description: A glycine receptor subunit alpha-3 that is encoded in the genome of human.


name: extracellularly glycine-gated chloride channel activity

description: Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.


name: glycine-gated chloride ion channel activity

description: Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts.


glycine-gated chloride channel complex

description: A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts.


name: ZPR1_HUMAN Zinc finger protein ZPR1 (sprot)

description: A zinc finger protein ZPR1 that is encoded in the genome of human.


trophectodermal cell proliferation

description: The proliferation of cells in the trophectoderm.


Cajal body organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors.


regulation of myelination

description: Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.


positive regulation of RNA splicing

description: Any process that activates or increases the frequency, rate or extent of RNA splicing.


DNA endoreduplication

description: Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes.


positive regulation of growth

description: Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.


pre-mRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA).


name: negative regulation of motor neuron apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process.


name: UBP12_HUMAN Ubiquitin carboxyl-terminal hydrolase 12 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 12 that is encoded in the genome of human.


name: DUS11_HUMAN RNA/RNP complex-1-interacting phosphatase (sprot)

description: An RNA/RNP complex-1-interacting phosphatase that is encoded in the genome of human.


phosphatase activity

description: Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.


name: NIPS2_HUMAN Protein NipSnap homolog 2 (sprot)

description: A protein NipSnap homolog 2 that is encoded in the genome of human.


oxidative phosphorylation

description: The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.


name: positive regulation of high voltage-gated calcium channel activity

description: Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity.


SNN_HUMAN Stannin (sprot)

A stannin that is encoded in the genome of human.


name: LRRN2_HUMAN Leucine-rich repeat neuronal protein 2 (sprot)

description: A leucine-rich repeat neuronal protein 2 that is encoded in the genome of human.


SEM7A_HUMAN Semaphorin-7A (sprot)

A semaphorin-7A that is encoded in the genome of human.


olfactory lobe development

description: The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell.


name: HMMR_HUMAN Hyaluronan mediated motility receptor (sprot)

description: A hyaluronan mediated motility receptor that is encoded in the genome of human.


name: TBX10_HUMAN T-box transcription factor TBX10 (sprot)

description: A T-box transcription factor TBX10 that is encoded in the genome of human.


LIPA2_HUMAN Liprin-alpha-2 (sprot)

A liprin-alpha-2 that is encoded in the genome of human.


structural constituent of presynapse

description: The action of a molecule that contributes to the structural integrity of a presynapse.


name: regulation of dendritic spine development

description: Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.


presynapse organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse.


name: dense core granule cytoskeletal transport

description: The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments.


postsynaptic specialization

description: A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.


LIPA4_HUMAN Liprin-alpha-4 (sprot)

A liprin-alpha-4 that is encoded in the genome of human.


name: CILP1_HUMAN Cartilage intermediate layer protein 1 (sprot)

description: A cartilage intermediate layer protein 1 that is encoded in the genome of human.


alkaline phosphatase activity

description: Catalysis of the reaction: a phosphate monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.


dinucleotide phosphatase activity

description: Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides.


name: negative regulation of insulin-like growth factor receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.


name: PDCD6_HUMAN Programmed cell death protein 6 (sprot)

description: A programmed cell death protein 6 that is encoded in the genome of human.


protein-membrane adaptor activity

description: The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle.


neural crest formation

description: The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.


name: positive regulation of protein monoubiquitination

description: Any process that activates or increases the frequency, rate or extent of protein monoubiquitination.


COPII vesicle coat

description: One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.


name: LX12B_HUMAN Arachidonate 12-lipoxygenase, 12R-type (sprot)

description: An arachidonate 12-lipoxygenase, 12R-type that is encoded in the genome of human.


description: Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.


name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

description: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.


isomerase activity

description: Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.


arachidonate 8(R)-lipoxygenase activity

description: Catalysis of the reaction: arachidonate + O2 = (5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate.


description: Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12R,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.


protein lipidation

description: The covalent attachment of lipid groups to an amino acid in a protein.


lipoxygenase pathway

description: The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase.


positive regulation of mucus secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.


name: GCYB2_HUMAN Guanylate cyclase soluble subunit beta-2 (sprot)

description: A guanylate cyclase soluble subunit beta-2 that is encoded in the genome of human.


cGMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.


name: FKBP6_HUMAN Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP6 that is encoded in the genome of human.


FK506 binding

description: Binding to a 23-membered macrolide lactone FK506.


piRNA processing

description: A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.


name: siRNA-mediated retrotransposon silencing by heterochromatin formation

description: A retrotransposon silencing mechanism in which a siRNA triggers heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription.


name: ZN253_HUMAN Zinc finger protein 253 (sprot)

description: A zinc finger protein 253 that is encoded in the genome of human.


name: TBCA_HUMAN Tubulin-specific chaperone A (sprot)

description: A tubulin-specific chaperone A that is encoded in the genome of human.


post-chaperonin tubulin folding pathway

description: Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors.


name: VATG1_HUMAN V-type proton ATPase subunit G 1 (sprot)

description: A V-type proton ATPase subunit G 1 that is encoded in the genome of human.


name: cellular response to increased oxygen levels

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen.


name: vacuolar proton-transporting V-type ATPase, V1 domain

description: The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.


transmembrane transporter complex

description: A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other.


name: VPS4B_HUMAN Vacuolar protein sorting-associated protein 4B (sprot)

description: A vacuolar protein sorting-associated protein 4B that is encoded in the genome of human.


name: endosome to lysosome transport via multivesicular body sorting pathway

description: The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome.


response to lipid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.


protein depolymerization

description: The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein.


late endosomal microautophagy

description: The autophagy process by which cytosolic proteins targeted for degradation are tagged with a chaperone and are directly transferred into and degraded in a late endosomal compartment.


name: late endosome to lysosome transport via multivesicular body sorting pathway

description: The directed movement of substances from late endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome.


name: ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide, via the multivesicular body (MVB) sorting pathway; proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. This process is independent of ubiquitination.


name: positive regulation of centriole elongation

description: Any process that activates or increases the frequency, rate or extent of centriole elongation.


ATPase complex

description: A protein complex which is capable of ATPase activity.


name: MPU1_HUMAN Mannose-P-dolichol utilization defect 1 protein (sprot)

description: A mannose-P-dolichol utilization defect 1 protein that is encoded in the genome of human.


name: ENTP6_HUMAN Ectonucleoside triphosphate diphosphohydrolase 6 (sprot)

description: An ectonucleoside triphosphate diphosphohydrolase 6 that is encoded in the genome of human.


GDP phosphatase activity

description: Catalysis of the reaction: GDP + H2O = GMP + phosphate.


description: Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate.


name: nucleoside diphosphate phosphatase activity

description: Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate.


CDP phosphatase activity

description: Catalysis of the reaction: CDP + H2O = CMP + phosphate.


UDP phosphatase activity

description: Catalysis of the reaction: UDP + H2O = UMP + phosphate.


IDP phosphatase activity

description: Catalysis of the reaction: IDP + H2O = IMP + H+ + phosphate.


name: ENTP3_HUMAN Ectonucleoside triphosphate diphosphohydrolase 3 (sprot)

description: An ectonucleoside triphosphate diphosphohydrolase 3 that is encoded in the genome of human.


apyrase activity

description: Catalysis of the reaction: a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate. This reaction consists of two distinct successive phosphate-releasing steps, with NDPs as intermediates. Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs).


name: ENTP5_HUMAN Nucleoside diphosphate phosphatase ENTPD5 (sprot)

description: A nucleoside diphosphate phosphatase ENTPD5 that is encoded in the genome of human.


UDP-glucose metabolic process

description: The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate.


protein N-linked glycosylation

description: A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.


UDP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate.


name: PROP1_HUMAN Homeobox protein prophet of Pit-1 (sprot)

description: A homeobox protein prophet of Pit-1 that is encoded in the genome of human.


hypothalamus cell differentiation

description: The differentiation of cells that will contribute to the structure and function of the hypothalamus.


hypophysis morphogenesis

description: The process in which the anatomical structures of the hypophysis are generated and organized. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.


name: somatotropin secreting cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.