name: PM2P1_HUMAN Putative postmeiotic segregation increased 2-like protein 1 (sprot)

description: A putative postmeiotic segregation increased 2-like protein 1 that is encoded in the genome of human.


kinase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


name: ATP-dependent DNA damage sensor activity

description: A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis.


mismatch repair

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.


mismatch repair complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any complex formed of proteins that act in mismatch repair.


name: O2A25_HUMAN Olfactory receptor 2A25 (sprot)

description: An olfactory receptor 2A25 that is encoded in the genome of human.


GRD2I_HUMAN Delphilin (sprot)

A delphilin that is encoded in the genome of human.


long-term synaptic depression

description: A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.


name: regulation of postsynaptic membrane neurotransmitter receptor levels

description: Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane.


name: regulation of postsynaptic cytosolic calcium ion concentration

description: Any process that regulates the concentration of calcium in the postsynaptic cytosol.


postsynaptic membrane

description: A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.


parallel fiber to Purkinje cell synapse

description: An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells.


name: postsynaptic density, intracellular component

description: A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.


name: cerebellar granule cell to Purkinje cell synapse

description: A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum.


name: MTMRB_HUMAN Myotubularin-related protein 11 (sprot)

description: A myotubularin-related protein 11 that is encoded in the genome of human.


name: SH321_HUMAN SH3 domain-containing protein 21 (sprot)

description: An SH3 domain-containing protein 21 that is encoded in the genome of human.


name: EFCB5_HUMAN EF-hand calcium-binding domain-containing protein 5 (sprot)

description: An EF-hand calcium-binding domain-containing protein 5 that is encoded in the genome of human.


name: EME2_HUMAN Probable crossover junction endonuclease EME2 (sprot)

description: A probable crossover junction endonuclease EME2 that is encoded in the genome of human.


replication fork processing

description: The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.


nuclear replication fork

description: The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.


endodeoxyribonuclease complex

description: A protein complex which is capable of endodeoxyribonuclease activity.


name: S35F4_HUMAN Solute carrier family 35 member F4 (sprot)

description: A solute carrier family 35 member F4 that is encoded in the genome of human.


name: CFA90_HUMAN Cilia- and flagella-associated protein 90 (sprot)

description: A cilia- and flagella-associated protein 90 that is encoded in the genome of human.


axoneme

description: The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.


axonemal B tubule inner sheath

description: A structural network of microtubule inner proteins (MIPs) located inside the lumen of the B tubule of the axonemal microtubule doublet that helps stabilize the B tubule.


name: PI4P2_HUMAN Putative phosphatidylinositol 4-kinase alpha-like protein P2 (sprot)

description: A putative phosphatidylinositol 4-kinase alpha-like protein P2 that is encoded in the genome of human.


name: phosphatidylinositol phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.


name: XIRP2_HUMAN Xin actin-binding repeat-containing protein 2 (sprot)

description: An Xin actin-binding repeat-containing protein 2 that is encoded in the genome of human.


stress fiber

description: A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.


focal adhesion

description: A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).


alpha-actinin binding

description: Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.


ventricular septum development

description: The progression of the ventricular septum over time from its formation to the mature structure.


cell-cell junction organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells.


cardiac muscle tissue morphogenesis

description: The process in which the anatomical structures of cardiac muscle tissue are generated and organized.


name: regulation of actin filament organization

description: Any process that modulates the frequency, rate or extent of actin filament organization.


Z disc

description: Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.


name: POTEF_HUMAN POTE ankyrin domain family member F (sprot)

description: A POTE ankyrin domain family member F that is encoded in the genome of human.


name: postsynaptic actin cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.


cell cortex

description: The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.


blood microparticle

description: A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.


name: FITM1_HUMAN Fat storage-inducing transmembrane protein 1 (sprot)

description: A fat storage-inducing transmembrane protein 1 that is encoded in the genome of human.


coenzyme A diphosphatase activity

description: Catalysis of the reaction:an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + 4'-phosphopantetheine. This reaction can also use coenzyme A as a substrate.


triglyceride binding

description: Binding to a triester of glycerol.


diacylglycerol binding

description: Binding to a diacylglycerol, a diester of glycerol and two fatty acids.


name: positive regulation of sequestering of triglyceride

description: Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.


lipid droplet organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.


lipid droplet formation

description: A process that results in the assembly, arrangement of constituent parts of a lipid droplet.


name: CL18A_HUMAN C-type lectin domain family 18 member A (sprot)

description: A C-type lectin domain family 18 member A that is encoded in the genome of human.


polysaccharide binding

description: Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.


endosome

description: A vacuole to which materials ingested by endocytosis are delivered.


name: VP37C_HUMAN Vacuolar protein sorting-associated protein 37C (sprot)

description: A vacuolar protein sorting-associated protein 37C that is encoded in the genome of human.


calcium-dependent protein binding

description: Binding to a protein or protein complex in the presence of calcium.


macroautophagy

description: The autophagic process that proceeds via the formation of an autophagosome.


multivesicular body assembly

description: The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.


viral budding via host ESCRT complex

description: Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process.


name: protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

description: The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway.


membrane fission

description: A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes.


ESCRT I complex

description: An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.


name: ODAD3_HUMAN Outer dynein arm-docking complex subunit 3 (sprot)

description: An outer dynein arm-docking complex subunit 3 that is encoded in the genome of human.


determination of left/right symmetry

description: The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.


outer dynein arm assembly

description: The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.


cilium movement

description: The directed, self-propelled movement of a cilium.


flagellated sperm motility

description: The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.


multicellular organism growth

description: The increase in size or mass of an entire multicellular organism, as opposed to cell growth.


name: epithelial cilium movement involved in determination of left/right asymmetry

description: The movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves.


name: determination of heart left/right asymmetry

description: Determination of the asymmetric location of the heart with respect to the left and right halves of the organism.


cerebrospinal fluid circulation

description: The neurological system process driven by motile cilia on ependymal cells of the brain by which cerebrospinal fluid circulates from the sites of secretion to the sites of absorption. In ventricular cavities, the flow is unidirectional and rostrocaudal, in subarachnoid spaces, the flow is multi-directional.


regulation of cilium assembly

description: Any process that modulates the frequency, rate or extent of cilium assembly.


outer dynein arm docking complex

description: A complex which stabilizes the binding of and correctly positions the outer dynein arm complex along an A-tubule of the flagellar axoneme outer doublet microtubules.


name: CFA69_HUMAN Cilia- and flagella-associated protein 69 (sprot)

description: A cilia- and flagella-associated protein 69 that is encoded in the genome of human.


sperm axoneme assembly

description: The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.


sensory perception of smell

description: The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.


olfactory behavior

description: The behavior of an organism in response to an odor.


name: positive regulation of flagellated sperm motility

description: Any process that activates or increases the frequency, rate or extent of flagellated sperm motility.


response to odorant

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell.


sperm midpiece

description: The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece.


non-motile cilium

description: A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.


name: PSB11_HUMAN Proteasome subunit beta type-11 (sprot)

description: A proteasome subunit beta type-11 that is encoded in the genome of human.


threonine-type endopeptidase activity

description: Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.


peptidase activity

description: Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.


name: CD8-positive, alpha-beta T cell differentiation

description: The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell.


name: proteasome core complex, beta-subunit complex

description: The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus.


name: PSD1_HUMAN PH and SEC7 domain-containing protein 1 (sprot)

description: A PH and SEC7 domain-containing protein 1 that is encoded in the genome of human.


neuron projection development

description: The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).


name: regulation of ARF protein signal transduction

description: Any process that modulates the frequency, rate or extent of ARF protein signal transduction.


cleavage furrow

description: The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.


ruffle membrane

description: The portion of the plasma membrane surrounding a ruffle.


dendritic spine

description: A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.


KRBA1_HUMAN Protein KRBA1 (sprot)

A protein KRBA1 that is encoded in the genome of human.


name: RGSL_HUMAN Regulator of G-protein signaling protein-like (sprot)

description: A regulator of G-protein signaling protein-like that is encoded in the genome of human.


name: AN34B_HUMAN Ankyrin repeat domain-containing protein 34B (sprot)

description: An ankyrin repeat domain-containing protein 34B that is encoded in the genome of human.


name: PDES1_HUMAN Plasmanylethanolamine desaturase 1 (sprot)

description: A plasmanylethanolamine desaturase 1 that is encoded in the genome of human.


description: Catalysis of the reaction:1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O.


fatty acid metabolic process

description: The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.


ether lipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.


name: TPC13_HUMAN Trafficking protein particle complex subunit 13 (sprot)

description: A trafficking protein particle complex subunit 13 that is encoded in the genome of human.


name: endoplasmic reticulum to Golgi vesicle-mediated transport

description: The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.


vesicle coating

description: A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination.


vesicle tethering

description: The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion.


TRAPPII protein complex

description: A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself.


name: 5HT3E_HUMAN 5-hydroxytryptamine receptor 3E (sprot)

description: A 5-hydroxytryptamine receptor 3E that is encoded in the genome of human.


name: serotonin-gated monoatomic cation channel activity

description: Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts.


serotonin receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.


excitatory postsynaptic potential

description: A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.


name: inorganic cation transmembrane transport

description: A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.


name: serotonin-activated cation-selective channel complex

description: A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist.


name: CNOT1_HUMAN CCR4-NOT transcription complex subunit 1 (sprot)

description: A CCR4-NOT transcription complex subunit 1 that is encoded in the genome of human.


poly(A)-specific ribonuclease activity

description: Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.


protein domain specific binding

description: Binding to a specific domain of a protein.


nuclear estrogen receptor binding

description: Binding to a nuclear estrogen receptor.


nuclear retinoic acid receptor binding

description: Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.


molecular adaptor activity

description: The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.


armadillo repeat domain binding

description: Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signaling and cytoskeletal regulation.


name: nuclear-transcribed mRNA poly(A) tail shortening

description: Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.


trophectodermal cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.


name: positive regulation of cytoplasmic mRNA processing body assembly

description: Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.


negative regulation of translation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.


name: negative regulation of intracellular estrogen receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.


name: miRNA-mediated post-transcriptional gene silencing

description: A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants.


name: negative regulation of retinoic acid receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity.


name: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

description: Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.


name: positive regulation of mRNA catabolic process

description: Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.


name: positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

description: Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.


name: regulation of stem cell population maintenance

description: Any process that modulates the frequency, rate or extent of stem cell population maintenance.


CCR4-NOT complex

description: The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8.


name: CRNS1_HUMAN Carnosine synthase 1 (sprot)

description: A carnosine synthase 1 that is encoded in the genome of human.


carnosine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine).


carnosine synthase activity

description: Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine.


homocarnosine synthase activity

description: Catalysis of the reaction: gamma-aminobutyric acid + L-histidine + ATP = H+ + homocarnosine + ADP + hydrogenphosphate.


L-histidine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.


name: MEG11_HUMAN Multiple epidermal growth factor-like domains protein 11 (sprot)

description: A multiple epidermal growth factor-like domains protein 11 that is encoded in the genome of human.


retina layer formation

description: The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.


homotypic cell-cell adhesion

description: The attachment of a cell to a second cell of the identical type via adhesion molecules.


basolateral plasma membrane

description: The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.


name: CDHR4_HUMAN Cadherin-related family member 4 (sprot)

description: A cadherin-like protein 29 that is encoded in the genome of human.


name: homophilic cell adhesion via plasma membrane adhesion molecules

description: The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.


name: BDP1_HUMAN Transcription factor TFIIIB component B'' homolog (sprot)

description: A transcription factor TFIIIB component B'' that is encoded in the genome of human.


F221B_HUMAN Protein FAM221B (sprot)

A protein FAM221B that is encoded in the genome of human.


name: T150B_HUMAN Modulator of macroautophagy TMEM150B (sprot)

description: A modulator of macroautophagy TMEM150B that is encoded in the genome of human.


autophagy

description: The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation.


name: PINLY_HUMAN phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (sprot)

description: A phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein that is encoded in the genome of human.


phospholipase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid.


name: ARB2P_HUMAN Putative protein ARB2BP (sprot)


name: CC88B_HUMAN Coiled-coil domain-containing protein 88B (sprot)

description: A coiled-coil domain-containing protein 88B that is encoded in the genome of human.


name: positive regulation of cytokine production

description: Any process that activates or increases the frequency, rate or extent of production of a cytokine.


name: positive regulation of T cell proliferation

description: Any process that activates or increases the rate or extent of T cell proliferation.


defense response to protozoan

description: Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.


name: positive regulation of T cell activation

description: Any process that activates or increases the frequency, rate or extent of T cell activation.


name: GOG8O_HUMAN Golgin subfamily A member 8O (sprot)

description: A protein that is a translation product of the GOLGA8O gene in human.


name: MP3B2_HUMAN Microtubule-associated proteins 1A/1B light chain 3 beta 2 (sprot)

description: A microtubule-associated proteins 1A/1B light chain 3 beta 2 that is encoded in the genome of human.


endomembrane system

description: A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.


cytoplasmic vesicle

description: A vesicle found in the cytoplasm of a cell.


name: VWA3A_HUMAN von Willebrand factor A domain-containing protein 3A (sprot)

description: A von Willebrand factor A domain-containing protein 3A that is encoded in the genome of human.


name: SIM16_HUMAN Putative transmembrane protein encoded by LINC00862 (sprot)


name: TKTI1_HUMAN Tektin bundle-interacting protein 1 (sprot)

description: A tektin bundle-interacting protein 1 that is encoded in the genome of human.


axonemal microtubule

description: A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.


name: TR43B_HUMAN Tripartite motif-containing protein 43B (sprot)

description: A tripartite motif-containing protein that is a translation product of the TRIM43B gene in human.


name: GEMC1_HUMAN Geminin coiled-coil domain-containing protein 1 (sprot)

description: A geminin coiled-coil domain-containing protein 1 that is encoded in the genome of human.


chromatin binding

description: Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.


DNA replication

description: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.


name: LRCL1_HUMAN Leucine-rich colipase-like protein 1 (sprot)

description: A leucine-rich colipase-like protein 1 that is encoded in the genome of human.


name: IQCAL_HUMAN IQ and AAA domain-containing protein 1-like (sprot)

description: An IQ and AAA domain-containing protein 1-like that is encoded in the genome of human.


microtubule cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.


name: KR87P_HUMAN Putative keratin-87 protein (sprot)


name: RN222_HUMAN RING finger protein 222 (sprot)

description: A RING finger protein 222 that is encoded in the genome of human.


name: NKX26_HUMAN Homeobox protein Nkx-2.6 (sprot)

description: A homeobox protein Nkx-2.6 that is encoded in the genome of human.


name: DNA-binding transcription activator activity, RNA polymerase II-specific

description: A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.


hypothalamus development

description: The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.


epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.


embryonic heart tube development

description: The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.


tongue development

description: The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.


digestive tract development

description: The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.


atrial cardiac muscle cell development

description: The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ.


name: ventricular cardiac muscle cell development

description: The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.


pharyngeal system development

description: The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.


pericardium development

description: The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery.


epithelial cell apoptotic process

description: Any apoptotic process in an epithelial cell.


name: negative regulation of epithelial cell apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process.


name: O6C74_HUMAN Olfactory receptor 6C74 (sprot)

description: An olfactory receptor 6C74 that is encoded in the genome of human.


name: U17L3_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 17-like protein 3 that is encoded in the genome of human.


name: U17L4_HUMAN Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4 (sprot)

description: An inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4 that is encoded in the genome of human.


name: JUNO_HUMAN Sperm-egg fusion protein Juno (sprot)

description: A sperm-egg fusion protein Juno that is encoded in the genome of human.


folic acid binding

description: Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.


signaling receptor activity

description: Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.


single fertilization

description: The union of male and female gametes to form a zygote.


name: fusion of sperm to egg plasma membrane involved in single fertilization

description: The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.


sperm-egg recognition

description: The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization.


microvillus membrane

description: The portion of the plasma membrane surrounding a microvillus.


FA83G_HUMAN Protein FAM83G (sprot)

A protein FAM83G that is encoded in the genome of human.


BMP signaling pathway

description: The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: O14I1_HUMAN Olfactory receptor 14I1 (sprot)

description: An olfactory receptor 14I1 that is encoded in the genome of human.


name: ASPDH_HUMAN Aspartate dehydrogenase domain-containing protein (sprot)

description: An aspartate dehydrogenase domain-containing protein that is encoded in the genome of human.


aspartate dehydrogenase activity

description: Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+.


NADP binding

description: Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.


NAD biosynthetic process

description: The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.


name: LRIT2_HUMAN Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 (sprot)

description: A leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 that is encoded in the genome of human.


PALM3_HUMAN Paralemmin-3 (sprot)

A paralemmin-3 that is encoded in the genome of human.


name: negative regulation of cytokine-mediated signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.


Toll signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to the receptor Toll on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


regulation of cell shape

description: Any process that modulates the surface configuration of a cell.


response to lipopolysaccharide

description: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.


name: SYN1L_HUMAN Synapse differentiation-inducing gene protein 1-like (sprot)

description: A capucin that is encoded in the genome of human.


name: RBY1B_HUMAN RNA-binding motif protein, Y chromosome, family 1 member B (sprot)

description: An RNA-binding motif protein, Y chromosome, family 1 member B that is encoded in the genome of human.


male gonad development

description: The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.


name: PGP_HUMAN Glycerol-3-phosphate phosphatase (sprot)

description: A glycerol-3-phosphate phosphatase that is encoded in the genome of human.


glycerol-1-phosphatase activity

description: Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate.


protein tyrosine phosphatase activity

description: Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


phosphoglycolate phosphatase activity

description: Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate.


glycerol-3-phosphatase activity

description: Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate.


ADP phosphatase activity

description: Catalysis of the reaction: ADP + H2O = AMP + phosphate + H+.


glycerol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.


glycerophospholipid metabolic process

description: The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.


negative regulation of gluconeogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.


name: O5H15_HUMAN Olfactory receptor 5H15 (sprot)

description: An olfactory receptor 5H15 that is encoded in the genome of human.


name: TR49B_HUMAN Putative tripartite motif-containing protein 49B (sprot)

description: A putative tripartite motif-containing protein 49B that is encoded in the genome of human.


name: MT21E_HUMAN Putative methyltransferase-like protein 21E pseudogene (sprot)


methylation

description: The process in which a methyl group is covalently attached to a molecule.


name: O6C68_HUMAN Olfactory receptor 6C68 (sprot)

description: An olfactory receptor 6C68 that is encoded in the genome of human.


name: MADL2_HUMAN Myeloid-associated differentiation marker-like protein 2 (sprot)

description: A myeloid-associated differentiation marker-like protein 2 that is encoded in the genome of human.


name: TBC3B_HUMAN TBC1 domain family member 3B (sprot)

description: A TBC1 domain family member 3B that is encoded in the genome of human.


name: RIMC1_HUMAN RAB7A-interacting MON1-CCZ1 complex subunit 1 (sprot)

description: A UPF0600 protein C5orf51 that is encoded in the genome of human.


mitophagy

description: The selective autophagy process in which a mitochondrion is degraded by macroautophagy.


name: TMM8B_HUMAN Transmembrane protein 8B (sprot)

description: A transmembrane protein 8B that is encoded in the genome of human.


cell-matrix adhesion

description: The binding of a cell to the extracellular matrix via adhesion molecules.


regulation of mitotic cell cycle

description: Any process that modulates the rate or extent of progress through the mitotic cell cycle.


cell surface

description: The external part of the cell wall and/or plasma membrane.


name: YO011_HUMAN Putative transmembrane protein ENSP00000320207 (sprot)


name: ZN840_HUMAN Putative zinc finger protein 840 (sprot)


name: EPAB2_HUMAN Embryonic polyadenylate-binding protein 2 (sprot)

description: An embryonic polyadenylate-binding protein 2 that is encoded in the genome of human.


name: BTBDH_HUMAN BTB/POZ domain-containing protein 17 (sprot)

description: A BTB/POZ domain-containing protein 17 that is encoded in the genome of human.


response to virus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.


name: negative regulation of viral genome replication

description: Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.


name: MB3L3_HUMAN Putative methyl-CpG-binding domain protein 3-like 3 (sprot)


name: PSAL_HUMAN Puromycin-sensitive aminopeptidase-like protein (sprot)


name: RCCD1_HUMAN RCC1 domain-containing protein 1 (sprot)

description: An RCC1 domain-containing protein 1 that is encoded in the genome of human.


chromatin organization

description: The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.


name: TM247_HUMAN Transmembrane protein 247 (sprot)

description: A transmembrane protein 247 that is encoded in the genome of human.


name: SWAHB_HUMAN Ankyrin repeat domain-containing protein SOWAHB (sprot)

description: An ankyrin repeat domain-containing protein SOWAHB that is encoded in the genome of human.


name: F86C2_HUMAN Putative protein FAM86C2P (sprot)


methyltransferase activity

description: Catalysis of the transfer of a methyl group to an acceptor molecule.


name: GG6L9_HUMAN Golgin subfamily A member 6-like protein 9 (sprot)

description: A golgin subfamily A member 6-like protein 9 that is encoded in the genome of human.


name: RBY1E_HUMAN RNA-binding motif protein, Y chromosome, family 1 member E (sprot)

description: An RNA-binding motif protein, Y chromosome, family 1 member E that is encoded in the genome of human.


name: TBC3F_HUMAN TBC1 domain family member 3F (sprot)

description: A TBC1 domain family member 3F that is encoded in the genome of human.


name: OR5K3_HUMAN Olfactory receptor 5K3 (sprot)

description: An olfactory receptor 5K3 that is encoded in the genome of human.


name: PRXD1_HUMAN Putative prolyl-tRNA synthetase associated domain-containing protein 1 (sprot)


aminoacyl-tRNA editing activity

description: The hydrolysis of an incorrectly aminoacylated tRNA.


name: aminoacyl-tRNA metabolism involved in translational fidelity

description: Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation.


name: P121B_HUMAN Putative nuclear envelope pore membrane protein POM 121B (sprot)


mRNA transport

description: The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: ANTRL_HUMAN Anthrax toxin receptor-like (sprot)

description: An anthrax toxin receptor-like that is encoded in the genome of human.


name: CC182_HUMAN Coiled-coil domain-containing protein 182 (sprot)

description: A coiled-coil domain-containing protein 182 that is encoded in the genome of human.


female gonad development

description: The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.


NUPR2_HUMAN Nuclear protein 2 (sprot)

A nuclear protein 2 that is encoded in the genome of human.


cellular response to starvation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.


regulation of cell cycle

description: Any process that modulates the rate or extent of progression through the cell cycle.


name: OR6C6_HUMAN Olfactory receptor 6C6 (sprot)

description: An olfactory receptor 6C6 that is encoded in the genome of human.


lipid droplet

description: An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.


S31F3_HUMAN Protein SPATA31F3 (sprot)

A protein SPATA31F3 that is encoded in the genome of human.


name: TIKI2_HUMAN Metalloprotease TIKI2 (sprot)

description: A metalloprotease TIKI2 that is encoded in the genome of human.


Wnt-protein binding

description: Binding to a Wnt-protein, a secreted growth factor involved in signaling.


name: negative regulation of Wnt signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.


name: positive regulation of protein-containing complex assembly

description: Any process that activates or increases the frequency, rate or extent of protein complex assembly.


name: positive regulation of protein oxidation

description: Any process that activates or increases the frequency, rate or extent of protein oxidation.


organelle membrane

description: A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.


name: TM235_HUMAN Transmembrane protein 235 (sprot)

description: A transmembrane protein 235 that is encoded in the genome of human.


name: OR2W5_HUMAN Putative olfactory receptor 2W5 pseudogene (sprot)

description: A protein that is a translation product of the OR2W5 gene in human.


name: HELT_HUMAN Hairy and enhancer of split-related protein HELT (sprot)

description: A hairy and enhancer of split-related protein HELT that is encoded in the genome of human.


protein dimerization activity

description: The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.


suckling behavior

description: Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast.


central nervous system development

description: The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.


post-embryonic development

description: The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.


name: GABAergic neuron differentiation in basal ganglia

description: The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron.


transcription regulator complex

description: A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.


name: SMCO2_HUMAN Single-pass membrane and coiled-coil domain-containing protein 2 (sprot)

description: A single-pass membrane and coiled-coil domain-containing protein 2 that is encoded in the genome of human.


name: EFC10_HUMAN EF-hand calcium-binding domain-containing protein 10 (sprot)

description: An EF-hand calcium-binding domain-containing protein 10 that is encoded in the genome of human.


name: NP1L6_HUMAN Putative nucleosome assembly protein 1-like 6 (sprot)


name: FBP12_HUMAN Fatty acid-binding protein 12 (sprot)

description: A fatty acid-binding protein 12 that is encoded in the genome of human.


name: ZN316_HUMAN Zinc finger protein 316 (sprot)

description: A zinc finger protein 316 that is encoded in the genome of human.


name: GRCR2_HUMAN Glutaredoxin domain-containing cysteine-rich protein 2 (sprot)

description: A glutaredoxin domain-containing cysteine-rich protein 2 that is encoded in the genome of human.


protein localization to organelle

description: A process in which a protein is transported to, or maintained in, a location within an organelle.


microvillus

description: Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.


name: RFOX3_HUMAN RNA binding protein fox-1 homolog 3 (sprot)

description: An RNA binding protein fox-1 homolog 3 that is encoded in the genome of human.


name: TCAF2_HUMAN TRPM8 channel-associated factor 2 (sprot)

description: A TRPM8 channel-associated factor 2 that is encoded in the genome of human.


name: negative regulation of anion channel activity

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity.


positive regulation of cell migration

description: Any process that activates or increases the frequency, rate or extent of cell migration.


name: positive regulation of protein targeting to membrane

description: Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.


name: DPRX_HUMAN Divergent paired-related homeobox (sprot)

description: A divergent paired-related homeobox that is encoded in the genome of human.


name: CE060_HUMAN Uncharacterized protein C5orf60 (sprot)

description: A protein that is a translation product of the C5orf60 gene in human.


name: CFA73_HUMAN Cilia- and flagella-associated protein 73 (sprot)

description: A cilia- and flagella-associated protein 73 that is encoded in the genome of human.


dynein complex binding

description: Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.


inner dynein arm assembly

description: The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.


axonemal outer doublet

description: Part of an axoneme consisting in a doublet microtubule. Nine of these outer doublets form the 9+0 axoneme, while the 9+2 axoneme also contains a central pair. Dynein arms attached to the doublets provide the mechanism of movement of the cilium.


name: F187A_HUMAN Ig-like V-type domain-containing protein FAM187A (sprot)

description: An Ig-like V-type domain-containing protein FAM187A that is encoded in the genome of human.


name: PGPIL_HUMAN Pyroglutamyl-peptidase 1-like protein (sprot)

description: A pyroglutamyl-peptidase 1-like protein that is encoded in the genome of human.


cysteine-type peptidase activity

description: Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


name: MFS2B_HUMAN Sphingosine-1-phosphate transporter MFSD2B (sprot)

description: A sphingosine-1-phosphate transporter MFSD2B that is encoded in the genome of human.


symporter activity

description: Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.


sphingolipid transporter activity

description: Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


name: sphingosine-1-phosphate receptor signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by sphingosine-1-phosphate binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


carbohydrate transport

description: The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.


sphingolipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


name: positive regulation of platelet aggregation

description: Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.


name: NEMP2_HUMAN Nuclear envelope integral membrane protein 2 (sprot)

description: A nuclear envelope integral membrane protein 2 that is encoded in the genome of human.


name: SDHF1_HUMAN Succinate dehydrogenase assembly factor 1, mitochondrial (sprot)

description: A succinate dehydrogenase assembly factor 1, mitochondrial that is encoded in the genome of human.


name: mitochondrial respiratory chain complex II assembly

description: The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane.


FA24A_HUMAN Protein FAM24A (sprot)

A protein FAM24A that is encoded in the genome of human.


name: MGT4D_HUMAN Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D (sprot)

description: An alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D that is encoded in the genome of human.


name: negative regulation of protein glycosylation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.


name: T191C_HUMAN Transmembrane protein 191C (sprot)

description: A transmembrane protein 191C that is encoded in the genome of human.


name: TM221_HUMAN Transmembrane protein 221 (sprot)

description: A transmembrane protein 221 that is encoded in the genome of human.


name: WIPF3_HUMAN WAS/WASL-interacting protein family member 3 (sprot)

description: A WAS/WASL-interacting protein family member 3 that is encoded in the genome of human.


name: TLCD2_HUMAN TLC domain-containing protein 2 (sprot)

description: A TLC domain-containing protein 2 that is encoded in the genome of human.


plasma membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.


phospholipid homeostasis

description: Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.


membrane assembly

description: The aggregation, arrangement and bonding together of a set of components to form a membrane.


name: regulation of membrane lipid distribution

description: Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane.


name: ZSA5C_HUMAN Zinc finger and SCAN domain-containing protein 5C (sprot)

description: A zinc finger and SCAN domain-containing protein 5C that is encoded in the genome of human.


name: URAD_HUMAN Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (sprot)

description: A putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase that is encoded in the genome of human.


carboxy-lyase activity

description: Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.


allantoin metabolic process

description: The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism.


purine nucleobase metabolic process

description: The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.


name: PCARE_HUMAN Photoreceptor cilium actin regulator (sprot)

description: A photoreceptor cilium actin regulator that is encoded in the genome of human.


visual perception

description: The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.


cone photoreceptor outer segment

description: The outer segment of a vertebrate cone photoreceptor that contains membrane discs that are contiguous with the ciliary membrane and containing opsin photoreceptor proteins.


name: ANR61_HUMAN Ankyrin repeat domain-containing protein 61 (sprot)

description: An ankyrin repeat domain-containing protein 61 that is encoded in the genome of human.


name: TRI64_HUMAN Tripartite motif-containing protein 64 (sprot)

description: A tripartite motif-containing protein 64 that is encoded in the genome of human.


GAG10_HUMAN G antigen 10 (sprot)

A G antigen 10 that is encoded in the genome of human.


name: PRA25_HUMAN PRAME family member 25 (sprot)

description: A protein that is a translation product of the PRAMEF25 gene in human.


name: IGLO5_HUMAN IgLON family member 5 (sprot)

description: An IgLON family member 5 that is encoded in the genome of human.


name: OOEP_HUMAN Oocyte-expressed protein homolog (sprot)

description: An oocyte-expressed protein that is encoded in the genome of human.


regulation of protein localization

description: Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.


name: positive regulation of meiotic nuclear division

description: Any process that activates or increases the frequency, rate or extent of meiosis.


establishment of spindle localization

description: The directed movement of the spindle to a specific location in the cell.


regulation of cell division

description: Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.


name: regulation of establishment of protein localization

description: Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.


name: positive regulation of double-strand break repair via homologous recombination

description: Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination.


name: positive regulation of double-strand break repair

description: Any process that activates or increases the frequency, rate or extent of double-strand break repair.


protein-containing complex

description: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.


subcortical maternal complex

description: Comprised of at least NLRP5, OOEP, TLE6, and KHDC3/KHDC3L with evidence of additional SCMC-associated proteins that interact with one or multiple members of the core complex.


name: ERIC4_HUMAN Glutamate-rich protein 4 (sprot)

description: A glutamate-rich protein 4 that is encoded in the genome of human.


name: GGT3_HUMAN Putative glutathione hydrolase 3 proenzyme (sprot)


name: leukotriene C4 gamma-glutamyl transferase activity

description: Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid.


glutathione biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.


leukotriene D4 biosynthetic process

description: The chemical reactions and pathways resulting in the formation of leukotriene D4.


name: STRCL_HUMAN Putative stereocilin-like protein (sprot)


FRG2C_HUMAN Protein FRG2-like-2 (sprot)

A protein FRG2-like-2 that is encoded in the genome of human.


name: O51F1_HUMAN Olfactory receptor 51F1 (sprot)

description: An olfactory receptor 51F1 that is encoded in the genome of human.


name: SMIM9_HUMAN Small integral membrane protein 9 (sprot)

description: A small integral membrane protein 9 that is encoded in the genome of human.


name: OR2T8_HUMAN Olfactory receptor 2T8 (sprot)

description: An olfactory receptor 2T8 that is encoded in the genome of human.


name: GLTD2_HUMAN Glycolipid transfer protein domain-containing protein 2 (sprot)

description: A glycolipid transfer protein domain-containing protein 2 that is encoded in the genome of human.


ceramide 1-phosphate transport

description: The directed movement of a ceramide 1-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: SERC4_HUMAN Serine incorporator 4 (sprot)

description: A serine incorporator 4 that is encoded in the genome of human.


phospholipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.


name: TV23A_HUMAN Golgi apparatus membrane protein TVP23 homolog A (sprot)

description: A protein FAM18A that is encoded in the genome of human.


name: ARL5C_HUMAN Putative ADP-ribosylation factor-like protein 5C (sprot)

description: A putative ADP-ribosylation factor-like protein 5C that is encoded in the genome of human.


name: O4C46_HUMAN Olfactory receptor 4C46 (sprot)

description: An olfactory receptor 4C46 that is encoded in the genome of human.


CAN8_HUMAN Calpain-8 (sprot)

A calpain-8 that is encoded in the genome of human.


name: DDTL_HUMAN D-dopachrome decarboxylase-like protein (sprot)

description: A D-dopachrome decarboxylase-like protein that is encoded in the genome of human.


name: O5H14_HUMAN Olfactory receptor 5H14 (sprot)

description: An olfactory receptor 5H14 that is encoded in the genome of human.


name: ZN860_HUMAN Zinc finger protein 860 (sprot)

description: A zinc finger protein 860 that is encoded in the genome of human.


name: TBAL3_HUMAN Tubulin alpha chain-like 3 (sprot)

description: A tubulin alpha chain-like 3 that is encoded in the genome of human.


hydrolase activity

description: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.


OTOL1_HUMAN Otolin-1 (sprot)

An otolin-1 that is encoded in the genome of human.


otolith mineralization

description: The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear.


protein homooligomerization

description: The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.


collagen trimer

description: A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.


name: NPB15_HUMAN Nuclear pore complex-interacting protein family member B15 (sprot)

description: A nuclear pore complex-interacting protein family member B15 that is encoded in the genome of human.


name: FBLL1_HUMAN rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 (sprot)

description: An rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 that is encoded in the genome of human.


blastocyst hatching

description: The hatching of the cellular blastocyst from the zona pellucida.


chromatin remodeling

description: A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.


fibrillar center

description: A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.


name: EPOP_HUMAN Elongin BC and Polycomb repressive complex 2-associated protein (sprot)

description: An elongin BC and Polycomb repressive complex 2-associated protein that is encoded in the genome of human.


protein-containing complex binding

description: Binding to a macromolecular complex.


stem cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.


name: transcription elongation-coupled chromatin remodeling

description: A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation.


ESC/E(Z) complex

description: A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.


elongin complex

description: A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits.


name: SMHD1_HUMAN Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (sprot)

description: A structural maintenance of chromosomes flexible hinge domain-containing protein 1 that is encoded in the genome of human.


chromosome, telomeric region

description: The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).


name: dosage compensation by inactivation of X chromosome

description: Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by heterochromatin formation leading to a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex.


nose development

description: The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).


positive regulation of DNA repair

description: Any process that activates or increases the frequency, rate or extent of DNA repair.


chromosome organization

description: A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.


name: negative regulation of double-strand break repair via homologous recombination

description: Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination.


name: positive regulation of double-strand break repair via nonhomologous end joining

description: Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining.


Barr body

description: A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.


site of double-strand break

description: A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.


name: HMX3_HUMAN Homeobox protein HMX3 (sprot)

description: A homeobox protein HMX3 that is encoded in the genome of human.


embryo implantation

description: Attachment of the blastocyst to the uterine lining.


name: neuromuscular process controlling balance

description: Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.


name: maternal process involved in female pregnancy

description: A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.


name: CAST2_HUMAN Cytosolic arginine sensor for mTORC1 subunit 2 (sprot)

description: A cytosolic arginine sensor for mTORC1 subunit 2 that is encoded in the genome of human.


arginine binding

description: Binding to 2-amino-5-(carbamimidamido)pentanoic acid.


GATOR2 complex

description: A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins.


name: AKD1B_HUMAN Ankyrin repeat and death domain-containing protein 1B (sprot)

description: An ankyrin repeat and death domain-containing protein 1B that is encoded in the genome of human.


name: TR64B_HUMAN Putative tripartite motif-containing protein 64B (sprot)


MSGN1_HUMAN Mesogenin-1 (sprot)

A mesogenin-1 that is encoded in the genome of human.


somitogenesis

description: The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.


segment specification

description: The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes.


name: RHG42_HUMAN Rho GTPase-activating protein 42 (sprot)

description: A Rho GTPase-activating protein 42 that is encoded in the genome of human.


name: negative regulation of systemic arterial blood pressure

description: The process that reduces the force with which blood travels through the systemic arterial circulatory system.


name: negative regulation of Rho protein signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.


activation of GTPase activity

description: Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.


name: negative regulation of vascular associated smooth muscle contraction

description: Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle contraction.


name: CC154_HUMAN Coiled-coil domain-containing protein 154 (sprot)

description: A coiled-coil domain-containing protein 154 that is encoded in the genome of human.


tooth eruption

description: The tooth development process in which the teeth enter the mouth and become visible.


bone resorption

description: The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.


MYMK_HUMAN Protein myomaker (sprot)

A protein myomaker that is encoded in the genome of human.


muscle organ development

description: The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.


name: positive regulation of skeletal muscle hypertrophy

description: Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy.


name: NCF1B_HUMAN Putative neutrophil cytosol factor 1B (sprot)


name: LIRA5_HUMAN Leukocyte immunoglobulin-like receptor subfamily A member 5 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily A member 5 that is encoded in the genome of human.


name: negative regulation of interleukin-12 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.


name: negative regulation of interleukin-13 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production.


name: positive regulation of interleukin-1 beta production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production.


name: positive regulation of interleukin-6 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.


name: positive regulation of tumor necrosis factor production

description: Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.


positive regulation of MAPK cascade

description: Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.


name: positive regulation of inflammatory response

description: Any process that activates or increases the frequency, rate or extent of the inflammatory response.


positive regulation of cell activation

description: Any process that activates or increases the frequency, rate or extent of activation.


name: positive regulation of calcium ion transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: positive regulation of protein tyrosine kinase activity

description: Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.


name: CCD69_HUMAN Coiled-coil domain-containing protein 69 (sprot)

description: A coiled-coil domain-containing protein 69 that is encoded in the genome of human.


spindle midzone assembly

description: The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap.


midbody

description: A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.


spindle midzone

description: The area in the center of the spindle where the spindle microtubules from opposite poles overlap.


name: U119B_HUMAN Protein unc-119 homolog B (sprot)

description: A protein unc-119 homolog B that is encoded in the genome of human.


lipid binding

description: Binding to a lipid.


lipoprotein transport

description: The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: O6C70_HUMAN Olfactory receptor 6C70 (sprot)

description: An olfactory receptor 6C70 that is encoded in the genome of human.


name: S15A5_HUMAN Solute carrier family 15 member 5 (sprot)

description: A solute carrier family 15 member 5 that is encoded in the genome of human.


peptide transport

description: The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: RN227_HUMAN RING finger protein 227 (sprot)

description: A RING finger protein 227 that is encoded in the genome of human.


name: AGAP5_HUMAN Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 (sprot)

description: An Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 that is encoded in the genome of human.


name: WTIP_HUMAN Wilms tumor protein 1-interacting protein (sprot)

description: A Wilms tumor protein 1-interacting protein that is encoded in the genome of human.


response to hypoxia

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.


cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.


regulation of cell morphogenesis

description: Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.


name: miRNA-mediated gene silencing by inhibition of translation

description: An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs.


negative regulation of hippo signaling

description: Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.


name: RP1BL_HUMAN Ras-related protein Rap-1b-like protein (sprot)

description: A protein that is a translation product of the RAP1BL gene in human.


name: NKX63_HUMAN Homeobox protein Nkx-6.3 (sprot)

description: A homeobox protein Nkx-6.3 that is encoded in the genome of human.


cell fate determination

description: The cellular developmental process involved in cell fate commitment that occurs after cell fate specification, in which a cell is irreversibly committed to a cellular developmental fate which is heritable on cell division.


name: negative regulation of epithelial cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.


name: NPIB2_HUMAN Putative nuclear pore complex-interacting protein family member B2 (sprot)


name: IGIP_HUMAN IgA-inducing protein homolog (sprot)

description: An IgA-inducing protein that is encoded in the genome of human.


name: MET15_HUMAN 12S rRNA N4-methylcytidine (m4C) methyltransferase (sprot)

description: A 12S rRNA N4-methylcytidine (m4C) methyltransferase that is encoded in the genome of human.


description: Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine.


rRNA base methylation

description: The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.


name: PRR19_HUMAN Proline-rich protein 19 (sprot)

description: A proline-rich protein 19 that is encoded in the genome of human.


meiotic cell cycle

description: Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.


name: ARGFX_HUMAN Arginine-fifty homeobox (sprot)

description: An arginine-fifty homeobox that is encoded in the genome of human.


name: ZSA5B_HUMAN Zinc finger and SCAN domain-containing protein 5B (sprot)

description: A zinc finger and SCAN domain-containing protein 5B that is encoded in the genome of human.


name: UNC4_HUMAN Homeobox protein unc-4 homolog (sprot)

description: A homeobox protein unc-4 that is encoded in the genome of human.


cartilage condensation

description: The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.


pattern specification process

description: Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.


dorsal spinal cord development

description: The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input.


name: olfactory bulb interneuron differentiation

description: The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb.


name: common myeloid progenitor cell proliferation

description: The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage.


regulation of cell differentiation

description: Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.


name: NPB13_HUMAN Nuclear pore complex-interacting protein family member B13 (sprot)

description: A protein that is a translation product of the NPIPB13 gene in human.


name: CMI2C_HUMAN Ciliary microtubule inner protein 2C (sprot)

description: A ciliary microtubule inner protein 2C that is encoded in the genome of human.


name: LRR3C_HUMAN Leucine-rich repeat-containing protein 3C (sprot)

description: A leucine-rich repeat-containing protein 3C that is encoded in the genome of human.


name: CD8B2_HUMAN T-cell surface glycoprotein CD8 beta-2 chain (sprot)

description: A protein that is a translation product of the CD8B2 gene in human.


coreceptor activity

description: Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.


MHC class I protein binding

description: Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.


regulation of immune response

description: Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.


name: SL9P1_HUMAN Putative SLC9B1-like protein SLC9B1P1 (sprot)


antiporter activity

description: Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).


proton transmembrane transport

description: The directed movement of a proton across a membrane.


name: T238L_HUMAN Transmembrane protein 238-like (sprot)

description: A protein that is a translation product of the TMEM238L gene in human.


name: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

description: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.


name: O6C65_HUMAN Olfactory receptor 6C65 (sprot)

description: An olfactory receptor 6C65 that is encoded in the genome of human.


name: RIM3C_HUMAN RIMS-binding protein 3C (sprot)

description: A RIMS-binding protein 3C that is encoded in the genome of human.


name: TRI75_HUMAN Tripartite motif-containing protein 75 (sprot)

description: A tripartite motif-containing protein 75 that is encoded in the genome of human.


female meiosis I

description: The cell cycle process in which the first meiotic division occurs in the female germline.


spindle

description: The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.


name: IRG1_HUMAN Cis-aconitate decarboxylase (sprot)

description: An immune-responsive gene 1 protein that is encoded in the genome of human.


aconitate decarboxylase activity

description: Catalysis of the reaction: cis-aconitate + H+ = CO2 + itaconate.


name: positive regulation of antimicrobial humoral response

description: Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response.


defense response

description: Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.


name: negative regulation of NF-kappaB transcription factor activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.


name: negative regulation of toll-like receptor 2 signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway.


name: negative regulation of toll-like receptor 4 signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.


cellular response to interferon-beta

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.


name: negative regulation of innate immune response

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.


defense response to virus

description: Reactions triggered in response to the presence of a virus that act to protect the cell or organism.


name: cellular response to molecule of bacterial origin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.


cellular response to type II interferon

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.


cellular response to interleukin-1

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.


name: cellular response to tumor necrosis factor

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.


name: cellular response to progesterone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.


name: tolerance induction to lipopolysaccharide

description: Tolerance induction directed at lipopolysaccharide antigens.


name: positive regulation of reactive oxygen species metabolic process

description: Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.


name: ZN233_HUMAN Zinc finger protein 233 (sprot)

description: A zinc finger protein 233 that is encoded in the genome of human.


name: regulation of DNA-templated transcription

description: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.


name: LIPT2_HUMAN Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial (sprot)

description: An octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial that is encoded in the genome of human.


lipoyl(octanoyl) transferase activity

description: Catalysis of the reaction: L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein].


protein lipoylation

description: The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.


carboxylic acid metabolic process

description: The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).


name: positive regulation of oxygen metabolic process

description: Any process that activates or increases the frequency, rate or extent of oxygen metabolic process.


name: ASB14_HUMAN Ankyrin repeat and SOCS box protein 14 (sprot)

description: An ankyrin repeat and SOCS box protein 14 that is encoded in the genome of human.


name: ZNF98_HUMAN Zinc finger protein 98 (sprot)

description: A zinc finger protein 98 that is encoded in the genome of human.


name: RASFA_HUMAN Ras association domain-containing protein 10 (sprot)

description: A Ras association domain-containing protein 10 that is encoded in the genome of human.