name: metanephric smooth muscle tissue development

description: The process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure.


metanephric cortex development

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process whose specific outcome is the progression of the metanephric cortex over time, from its formation to the mature structure. The metanephric cortex is the outer region of the metanephros.


name: metanephric cortical collecting duct development

description: The process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex.


metanephric distal tubule development

description: The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule.


name: ULA1_HUMAN NEDD8-activating enzyme E1 regulatory subunit (sprot)

description: A NEDD8-activating enzyme E1 regulatory subunit that is encoded in the genome of human.


NEDD8 activating enzyme activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.


name: mitotic DNA replication checkpoint signaling

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A signal transduction process that contributes to a mitotic DNA replication checkpoint.


name: IRF5_HUMAN Interferon regulatory factor 5 (sprot)

description: An interferon regulatory factor 5 that is encoded in the genome of human.


name: TDG_HUMAN G/T mismatch-specific thymine DNA glycosylase (sprot)

description: A G/T mismatch-specific thymine DNA glycosylase that is encoded in the genome of human.


name: G/U mismatch-specific uracil-DNA glycosylase activity

description: Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil and leaving an apyrimidinic (AP) site.


name: G/T mismatch-specific thymine-DNA glycosylase activity

description: Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine and leaving an apyrimidinic (AP) site.


name: LAPM5_HUMAN Lysosomal-associated transmembrane protein 5 (sprot)

description: A lysosomal-associated transmembrane protein 5 that is encoded in the genome of human.


induction of programmed cell death

description: A process which directly activates any of the steps required for programmed cell death.


name: negative regulation of autophagic cell death

description: Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death.


name: ITPK1_HUMAN Inositol-tetrakisphosphate 1-kinase (sprot)

description: An inositol-tetrakisphosphate 1-kinase that is encoded in the genome of human.


name: inositol tetrakisphosphate 6-kinase activity

description: Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP.


name: inositol tetrakisphosphate 1-kinase activity

description: Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP.


description: Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H+.


description: Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+.


description: Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H+.


name: SNW1_HUMAN SNW domain-containing protein 1 (sprot)

description: A SNW domain-containing protein 1 that is encoded in the genome of human.


name: DGKZ_HUMAN Diacylglycerol kinase zeta (sprot)

description: A diacylglycerol kinase zeta that is encoded in the genome of human.


name: IQGA2_HUMAN Ras GTPase-activating-like protein IQGAP2 (sprot)

description: A Ras GTPase-activating-like protein IQGAP2 that is encoded in the genome of human.


name: MTR1L_HUMAN Melatonin-related receptor (sprot)

description: A melatonin-related receptor that is encoded in the genome of human.


name: STIM1_HUMAN Stromal interaction molecule 1 (sprot)

description: A stromal interaction molecule 1 that is encoded in the genome of human.


name: activation of store-operated calcium channel activity

description: A process that initiates the activity of an inactive store-operated calcium channel.


name: GRAP_HUMAN GRB2-related adapter protein (sprot)

description: A GRB2-related adapter protein that is encoded in the genome of human.


SEM5A_HUMAN Semaphorin-5A (sprot)

A semaphorin-5A that is encoded in the genome of human.


signal clustering

description: Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response.


name: TRA2A_HUMAN Transformer-2 protein homolog alpha (sprot)

description: A transformer-2 protein homolog alpha that is encoded in the genome of human.


SNX1_HUMAN Sorting nexin-1 (sprot)

A sorting nexin-1 that is encoded in the genome of human.


name: KRR1_HUMAN KRR1 small subunit processome component homolog (sprot)

description: A KRR1 small subunit processome component that is encoded in the genome of human.


name: OR5I1_HUMAN Olfactory receptor 5I1 (sprot)

description: An olfactory receptor 5I1 that is encoded in the genome of human.


name: OR2F1_HUMAN Olfactory receptor 2F1 (sprot)

description: An olfactory receptor 2F1 that is encoded in the genome of human.


name: PEX6_HUMAN Peroxisomal ATPase PEX6 (sprot)

description: A peroxisomal ATPase PEX6 that is encoded in the genome of human.


photoreceptor cell cilium

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment.


name: DNSL3_HUMAN Deoxyribonuclease gamma (sprot)

description: A deoxyribonuclease gamma that is encoded in the genome of human.


name: PWP1_HUMAN Periodic tryptophan protein 1 homolog (sprot)

description: A periodic tryptophan protein 1 that is encoded in the genome of human.


H4K20me3 modified histone binding

description: Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation.


name: MTMR1_HUMAN Myotubularin-related protein 1 (sprot)

description: A myotubularin-related protein 1 that is encoded in the genome of human.


name: MTMR2_HUMAN Myotubularin-related protein 2 (sprot)

description: A myotubularin-related protein 2 that is encoded in the genome of human.


name: negative regulation of receptor catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of receptor catabolic process.


name: MTMR3_HUMAN Myotubularin-related protein 3 (sprot)

description: A myotubularin-related protein 3 that is encoded in the genome of human.


name: phosphatidylinositol 5-phosphate metabolic process

description: The chemical reactions and pathways involving phosphatidylinositol 5-phosphate.


CUL1_HUMAN Cullin-1 (sprot)

A fungal/metazoan cullin-1 that is encoded in the genome of human.


CUL2_HUMAN Cullin-2 (sprot)

A cullin-2 that is encoded in the genome of human.


VCB complex

description: A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.


CUL3_HUMAN Cullin-3 (sprot)

A cullin-3 that is encoded in the genome of human.


trophectodermal cellular morphogenesis

description: The morphogenesis of trophectoderm cells.


name: regulation protein catabolic process at postsynapse

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse.


CUL4A_HUMAN Cullin-4A (sprot)

A cullin-4A that is encoded in the genome of human.


CUL4B_HUMAN Cullin-4B (sprot)

A cullin-4B that is encoded in the genome of human.


name: S12A1_HUMAN Solute carrier family 12 member 1 (sprot)

description: A solute carrier family 12 member 1 that is encoded in the genome of human.


name: ASPP2_HUMAN Apoptosis-stimulating of p53 protein 2 (sprot)

description: An apoptosis-stimulating of p53 protein 2 that is encoded in the genome of human.


name: DYR1A_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1A (sprot)

description: A dual specificity tyrosine-phosphorylation-regulated kinase 1A that is encoded in the genome of human.


histone H3T45 kinase activity

description: Catalysis of the reaction: histone H3-threonine (position 45) + ATP = histone H3-phosphothreonine (position 45) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 45 of histone H3.


FCL_HUMAN GDP-L-fucose synthase (sprot)

A GDP-L-fucose synthetase that is encoded in the genome of human.


description: Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed.


GDP-mannose 3,5-epimerase activity

description: Catalysis of the reaction: GDP-mannose = GDP-L-galactose.


GDP-L-fucose synthase activity

description: Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+.


CAD18_HUMAN Cadherin-18 (sprot)

A cadherin-18 that is encoded in the genome of human.


name: PTC1_HUMAN Protein patched homolog 1 (sprot)

description: A protein patched homolog 1 that is encoded in the genome of human.


smoothened binding

description: Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals.


hedgehog family protein binding

description: Binding to a member of the hedgehog protein family, signaling proteins involved in development.


neural tube patterning

description: The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube.


neural plate axis specification

description: The pattern specification process in which the axes of the nervous system are established.


name: RAB31_HUMAN Ras-related protein Rab-31 (sprot)

description: A Ras-related protein Rab-31 that is encoded in the genome of human.


early phagosome membrane

description: The lipid bilayer surrounding an early phagosome.


name: RAB32_HUMAN Ras-related protein Rab-32 (sprot)

description: A Ras-related protein Rab-32 that is encoded in the genome of human.


name: 5HT4R_HUMAN 5-hydroxytryptamine receptor 4 (sprot)

description: A 5-hydroxytryptamine receptor 4 that is encoded in the genome of human.


serotonin receptor activity

description: Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.


large intestinal transit

description: Migration of ingested material along the length of the large intestine.


name: TPBG_HUMAN Trophoblast glycoprotein (sprot)

description: A trophoblast glycoprotein that is encoded in the genome of human.


name: FHL1_HUMAN Four and a half LIM domains protein 1 (sprot)

description: A four and a half LIM domains protein 1 that is encoded in the genome of human.


name: FHL3_HUMAN Four and a half LIM domains protein 3 (sprot)

description: A four and a half LIM domains protein 3 that is encoded in the genome of human.


name: I10R1_HUMAN Interleukin-10 receptor subunit alpha (sprot)

description: An interleukin-10 receptor subunit alpha that is encoded in the genome of human.


interleukin-10 binding

description: Binding to interleukin-10.


name: PM2PB_HUMAN Putative postmeiotic segregation increased 2-like protein 11 (sprot)

description: A putative postmeiotic segregation increased 2-like protein 11 that is encoded in the genome of human.


name: RIN1_HUMAN Ras and Rab interactor 1 (sprot)

description: A Ras and Rab interactor 1 that is encoded in the genome of human.


ITA7_HUMAN Integrin alpha-7 (sprot)

An integrin alpha-7 that is encoded in the genome of human.


name: AAMP_HUMAN Angio-associated migratory cell protein (sprot)

description: An angio-associated migratory cell protein that is encoded in the genome of human.


name: ALKB1_HUMAN Nucleic acid dioxygenase ALKBH1 (sprot)

description: A nucleic acid dioxygenase ALKBH1 that is encoded in the genome of human.


description: Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.


oxidative RNA demethylase activity

description: Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.


name: broad specificity oxidative DNA demethylase activity

description: Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA.


name: DNA N6-methyladenine demethylase activity

description: Catalysis of the reaction: 2-oxoglutarate + an N6-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate.


tRNA demethylase activity

description: Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule.


tRNA wobble cytosine modification

description: The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified.


oxidative RNA demethylation

description: The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms.


RNA repair

description: Any process that results in the repair of damaged RNA.


name: positive regulation of gene expression, epigenetic

description: An epigenetic process that increases gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA demethylation.


name: regulation of translational initiation by tRNA modification

description: A process in which translation initiation is regulated by post-translation modifications of a tRNA molecule.


name: CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S (sprot)

description: A voltage-dependent L-type calcium channel subunit alpha-1S that is encoded in the genome of human.


name: RAPSN_HUMAN 43 kDa receptor-associated protein of the synapse (sprot)

description: A 43 kDa receptor-associated protein of the synapse that is encoded in the genome of human.


name: structural constituent of postsynaptic specialization

description: The action of a molecule that contributes to the structural integrity of a postsynaptic specialization.


name: regulation of postsynaptic membrane organization

description: Any process that modulates the frequency, rate or extent of postsynaptic membrane organization.


name: establishment of protein localization to postsynaptic membrane

description: The directed movement of a protein to a specific location in a postsynaptic membrane.


name: AVR2B_HUMAN Activin receptor type-2B (sprot)

description: An activin receptor type-2B that is encoded in the genome of human.


activin receptor activity, type II

description: Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor.


name: MOGS_HUMAN Mannosyl-oligosaccharide glucosidase (sprot)

description: A mannosyl-oligosaccharide glucosidase that is encoded in the genome of human.


name: Glc3Man9GlcNAc2 oligosaccharide glucosidase activity

description: Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2).


glucosidase activity

description: Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative.


name: AT1A4_HUMAN Sodium/potassium-transporting ATPase subunit alpha-4 (sprot)

description: A sodium/potassium-transporting ATPase subunit alpha-4 that is encoded in the genome of human.


CD166_HUMAN CD166 antigen (sprot)

A CD166 molecule that is encoded in the genome of human.


name: LAMB3_HUMAN Laminin subunit beta-3 (sprot)

description: A laminin subunit beta-3 that is encoded in the genome of human.


name: LAMC2_HUMAN Laminin subunit gamma-2 (sprot)

description: A laminin subunit gamma-2 that is encoded in the genome of human.


name: RUNX3_HUMAN Runt-related transcription factor 3 (sprot)

description: A runt-related transcription factor 3 that is encoded in the genome of human.


name: NACA_HUMAN Nascent polypeptide-associated complex subunit alpha (sprot)


name: regulation of skeletal muscle fiber development

description: Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.


name: THOC5_HUMAN THO complex subunit 5 homolog (sprot)

description: A THO complex subunit 5 that is encoded in the genome of human.


THO complex

description: The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.


name: THO complex part of transcription export complex

description: The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.


name: NCOA4_HUMAN Nuclear receptor coactivator 4 (sprot)

description: A nuclear receptor coactivator 4 that is encoded in the genome of human.


APOF_HUMAN Apolipoprotein F (sprot)

An apolipoprotein F that is encoded in the genome of human.


name: APR_HUMAN Phorbol-12-myristate-13-acetate-induced protein 1 (sprot)

description: A phorbol-12-myristate-13-acetate-induced protein 1 that is encoded in the genome of human.


response to dsRNA

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus.


name: ARFRP_HUMAN ADP-ribosylation factor-related protein 1 (sprot)

description: An ADP-ribosylation factor-related protein 1 that is encoded in the genome of human.


SHRM2_HUMAN Protein Shroom2 (sprot)

A protein Shroom2 that is encoded in the genome of human.


eye pigment granule organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye.


name: establishment of melanosome localization

description: The directed movement of a melanosome to a specific location.


cellular pigment accumulation

description: The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus.


ITA9_HUMAN Integrin alpha-9 (sprot)

An integrin alpha-9 that is encoded in the genome of human.


name: SPTN1_HUMAN Spectrin alpha chain, non-erythrocytic 1 (sprot)

description: A spectrin alpha chain, non-erythrocytic 1 that is encoded in the genome of human.


name: ENPP2_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (sprot)

description: An ectonucleotide pyrophosphatase/phosphodiesterase family member 2 that is encoded in the genome of human.


name: NOG2_HUMAN Nucleolar GTP-binding protein 2 (sprot)

description: A nucleolar GTP-binding protein 2 that is encoded in the genome of human.


name: AUHM_HUMAN Methylglutaconyl-CoA hydratase, mitochondrial (sprot)

description: A methylglutaconyl-CoA hydratase, mitochondrial that is encoded in the genome of human.


methylglutaconyl-CoA hydratase activity

description: Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O.


itaconyl-CoA hydratase activity

description: Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O.


name: BACD2_HUMAN BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (sprot)

description: A BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 that is encoded in the genome of human.


PKP1_HUMAN Plakophilin-1 (sprot)

A plakophilin-1 that is encoded in the genome of human.


name: DX39B_HUMAN Spliceosome RNA helicase DDX39B (sprot)

description: A spliceosome RNA helicase BAT1 that is encoded in the genome of human.


U6 snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U6, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6 snRNP, most of which remain associated with the U6 snRNA both while the U6 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes.


BLMH_HUMAN Bleomycin hydrolase (sprot)

A bleomycin hydrolase that is encoded in the genome of human.


cysteine-type aminopeptidase activity

description: Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


name: EXOS2_HUMAN Exosome complex component RRP4 (sprot)

description: An exosome complex component RRP4 that is encoded in the genome of human.


name: BMPR2_HUMAN Bone morphogenetic protein receptor type-2 (sprot)

description: A BMP receptor type-2 that is encoded in the genome of human.


semi-lunar valve development

description: The process whose specific outcome is the progression of a semi-lunar valve over time, from its formation to the mature structure.


name: MOBP_HUMAN Myelin-associated oligodendrocyte basic protein (sprot)

description: A myelin-associated oligodendrocyte basic protein that is encoded in the genome of human.


name: PTK6_HUMAN Protein-tyrosine kinase 6 (sprot)

description: A protein-tyrosine kinase 6 that is encoded in the genome of human.


SNTB1_HUMAN Beta-1-syntrophin (sprot)

A beta-1-syntrophin that is encoded in the genome of human.


name: TBB2A_HUMAN Tubulin beta-2A chain (sprot)

description: A tubulin beta-2A chain that is encoded in the genome of human.


name: KLF9_HUMAN Krueppel-like factor 9 (sprot)

description: A krueppel-like factor 9 that is encoded in the genome of human.


cellular response to cortisol stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.


name: KLF5_HUMAN Krueppel-like factor 5 (sprot)

description: A krueppel-like factor 5 that is encoded in the genome of human.


name: positive regulation of transcription by transcription factor localization

description: Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor.


cell-cell signaling via exosome

description: Cell-cell signaling in which the ligand is carried between cells by an exosome.


name: TF2H2_HUMAN General transcription factor IIH subunit 2 (sprot)

description: A general transcription factor IIH subunit 2 that is encoded in the genome of human.


name: core TFIIH complex portion of holo TFIIH complex

description: The core TFIIH complex when it is part of the general transcription factor TFIIH.


name: TF2H3_HUMAN General transcription factor IIH subunit 3 (sprot)

description: A general transcription factor IIH subunit 3 that is encoded in the genome of human.


BYST_HUMAN Bystin (sprot)

A bystin that is encoded in the genome of human.


name: C1D_HUMAN Nuclear nucleic acid-binding protein C1D (sprot)

description: A nuclear nucleic acid-binding protein C1D that is encoded in the genome of human.


name: RPGF1_HUMAN Rap guanine nucleotide exchange factor 1 (sprot)

description: A Rap guanine nucleotide exchange factor 1 that is encoded in the genome of human.


name: IDI1_HUMAN Isopentenyl-diphosphate Delta-isomerase 1 (sprot)

description: An isopentenyl-diphosphate Delta-isomerase 1 that is encoded in the genome of human.


name: dimethylallyl diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate.


name: CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)

description: A voltage-dependent L-type calcium channel subunit alpha-1C that is encoded in the genome of human.


CAYP1_HUMAN Calcyphosin (sprot)

A calcyphosin that is encoded in the genome of human.


CALI_HUMAN Calicin (sprot)

A calicin that is encoded in the genome of human.


name: PDE7A_HUMAN High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (sprot)

description: A high affinity 3',5'-cyclic-AMP phosphodiesterase 7A that is encoded in the genome of human.


CASP_HUMAN Protein CASP (sprot)

A protein CASP (human), isoforms CASP, h8, h9, and h10.


name: RUNX2_HUMAN Runt-related transcription factor 2 (sprot)

description: A runt-related transcription factor 2 that is encoded in the genome of human.


osteoblast fate commitment

description: The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.


ligamentous ossification

description: Ossification wherein bone tissue forms within ligamentous tissue.


name: PEBB_HUMAN Core-binding factor subunit beta (sprot)

description: A core-binding factor subunit beta that is encoded in the genome of human.


name: NFYC_HUMAN Nuclear transcription factor Y subunit gamma (sprot)

description: A nuclear transcription factor Y subunit gamma that is encoded in the genome of human.


name: CNCG_HUMAN Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (sprot)

description: A retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma that is encoded in the genome of human.


name: RGRF1_HUMAN Ras-specific guanine nucleotide-releasing factor 1 (sprot)

description: A Ras-specific guanine nucleotide-releasing factor 1 that is encoded in the genome of human.


name: KGP1_HUMAN cGMP-dependent protein kinase 1 (sprot)

description: A cGMP-dependent protein kinase 1 that is encoded in the genome of human.


name: CEAM7_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 7 (sprot)

description: A carcinoembryonic antigen-related cell adhesion molecule 7 that is encoded in the genome of human.


name: KCNC3_HUMAN Potassium voltage-gated channel subfamily C member 3 (sprot)

description: A voltage-gated potassium channel KCNC3 that is encoded in the genome of human.


name: CDK13_HUMAN Cyclin-dependent kinase 13 (sprot)

description: A cyclin-dependent kinase 13 that is encoded in the genome of human.


name: nuclear cyclin-dependent protein kinase holoenzyme complex

description: Cyclin-dependent protein kinase (CDK) complex found in the nucleus.


IL16_HUMAN Pro-interleukin-16 (sprot)

An interleukin-16 that is encoded in the genome of human.


name: CKAP5_HUMAN Cytoskeleton-associated protein 5 (sprot)

description: A cytoskeleton-associated protein 5 that is encoded in the genome of human.


name: CIRBP_HUMAN Cold-inducible RNA-binding protein (sprot)

description: A cold-inducible RNA-binding protein that is encoded in the genome of human.


name: KCC1A_HUMAN Calcium/calmodulin-dependent protein kinase type 1 (sprot)

description: A calcium/calmodulin-dependent protein kinase type 1 that is encoded in the genome of human.


name: COTL1_HUMAN Coactosin-like protein (sprot)

description: A coactosin-like protein that is encoded in the genome of human.


name: CNGB1_HUMAN Cyclic nucleotide-gated channel beta-1 (sprot)

description: A cyclic nucleotide-gated cation channel beta-1 that is encoded in the genome of human.


olfactory nerve maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.


non-motile cilium membrane

description: The portion of the plasma membrane surrounding a non-motile cilium.


name: CO4A6_HUMAN Collagen alpha-6(IV) chain (sprot)

description: A collagen alpha-6(IV) chain that is encoded in the genome of human.


name: BAAT_HUMAN Bile acid-CoA:amino acid N-acyltransferase (sprot)

description: A bile acid-CoA:amino acid N-acyltransferase that is encoded in the genome of human.


glycine N-choloyltransferase activity

description: Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate.


bile acid conjugation

description: The process in which bile acids are covalently linked to taurine or glycine.


name: CO9A3_HUMAN Collagen alpha-3(IX) chain (sprot)

description: A collagen alpha-3(IX) chain that is encoded in the genome of human.


name: CO9A2_HUMAN Collagen alpha-2(IX) chain (sprot)

description: A collagen alpha-2(IX) chain that is encoded in the genome of human.


name: COX17_HUMAN Cytochrome c oxidase copper chaperone (sprot)

description: A cytochrome c oxidase copper chaperone that is encoded in the genome of human.


name: RB33A_HUMAN Ras-related protein Rab-33A (sprot)

description: A Ras-related protein Rab-33A that is encoded in the genome of human.


CYLC2_HUMAN Cylicin-2 (sprot)

A cylicin-2 that is encoded in the genome of human.


CCNI_HUMAN Cyclin-I (sprot)

A cyclin-I that is encoded in the genome of human.


name: HNRPD_HUMAN Heterogeneous nuclear ribonucleoprotein D0 (sprot)

description: A heterogeneous nuclear ribonucleoprotein D0 that is encoded in the genome of human.


cellular response to putrescine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a putrescine stimulus.


hepatocyte dedifferentiation

description: The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.


TOB2_HUMAN Protein Tob2 (sprot)

A protein Tob2 that is encoded in the genome of human.


name: SCRB2_HUMAN Lysosome membrane protein 2 (sprot)

description: A lysosome membrane protein 2 that is encoded in the genome of human.


aminophospholipid transport

description: The directed movement of aminophospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group.


name: regulation of carbohydrate catabolic process

description: Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates.


regulation of lysosome organization

description: Any process that modulates the frequency, rate or extent of lysosome organization.


name: regulation of glucosylceramide catabolic process

description: Any process that modulates the frequency, rate or extent of glucosylceramide catabolic process.


NID2_HUMAN Nidogen-2 (sprot)

A nidogen-2 that is encoded in the genome of human.


name: LRP8_HUMAN Low-density lipoprotein receptor-related protein 8 (sprot)

description: A low-density lipoprotein receptor-related protein 8 that is encoded in the genome of human.


ammon gyrus development

description: The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons.


IL18_HUMAN Interleukin-18 (sprot)

An interleukin-18 that is encoded in the genome of human.


interleukin-18 receptor binding

description: Binding to an interleukin-18 receptor.


DPYS_HUMAN Dihydropyrimidinase (sprot)

A dihydropyrimidinase that is encoded in the genome of human.


dihydropyrimidinase activity

description: Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate.


DAG1_HUMAN Dystroglycan 1 (sprot)

A dystroglycan 1 that is encoded in the genome of human.


calcium-dependent cell-matrix adhesion

description: The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction.


nerve maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state.


name: retrograde trans-synaptic signaling by trans-synaptic protein complex

description: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex.


name: VEZF1_HUMAN Vascular endothelial zinc finger 1 (sprot)

description: A vascular endothelial zinc finger 1 that is encoded in the genome of human.


name: PDE1C_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (sprot)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C that is encoded in the genome of human.


DSG2_HUMAN Desmoglein-2 (sprot)

A desmoglein-2 that is encoded in the genome of human.


DGCR6_HUMAN Protein DGCR6 (sprot)

A protein DGCR6 that is encoded in the genome of human.


name: TRI29_HUMAN Tripartite motif-containing protein 29 (sprot)

description: A tripartite motif-containing protein 29 that is encoded in the genome of human.


name: VGLL4_HUMAN Transcription cofactor vestigial-like protein 4 (sprot)

description: A transcription cofactor vestigial-like protein 4 that is encoded in the genome of human.


name: BOP1_HUMAN Ribosome biogenesis protein BOP1 (sprot)

description: A ribosome biogenesis protein BOP1 that is encoded in the genome of human.


name: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.


name: UBE4A_HUMAN Ubiquitin conjugation factor E4 A (sprot)

description: A ubiquitin conjugation factor E4 A that is encoded in the genome of human.


name: SRTD2_HUMAN SERTA domain-containing protein 2 (sprot)

description: A SERTA domain-containing protein 2 that is encoded in the genome of human.


SEPT6_HUMAN Septin-6 (sprot)

A septin-6 that is encoded in the genome of human.


septin collar

description: A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell.


name: TRI14_HUMAN Tripartite motif-containing protein 14 (sprot)

description: A tripartite motif-containing protein 14 that is encoded in the genome of human.


name: KEAP1_HUMAN Kelch-like ECH-associated protein 1 (sprot)

description: A kelch-like ECH-associated protein 1 that is encoded in the genome of human.


name: URB2_HUMAN Unhealthy ribosome biogenesis protein 2 homolog (sprot)

description: An unhealthy ribosome biogenesis protein 2 that is encoded in the genome of human.


name: DHX34_HUMAN Probable ATP-dependent RNA helicase DHX34 (sprot)

description: A probable ATP-dependent RNA helicase DHX34 that is encoded in the genome of human.


name: MORC3_HUMAN MORC family CW-type zinc finger protein 3 (sprot)

description: A MORC family CW-type zinc finger protein 3 that is encoded in the genome of human.


name: SAFB2_HUMAN Scaffold attachment factor B2 (sprot)

description: A scaffold attachment factor B2 that is encoded in the genome of human.


name: EIF3A_HUMAN Eukaryotic translation initiation factor 3 subunit A (sprot)

description: A eukaryotic translation initiation factor 3 subunit A that is encoded in the genome of human.


FA53B_HUMAN Protein FAM53B (sprot)

A protein FAM53B that is encoded in the genome of human.


name: DELE1_HUMAN DAP3-binding cell death enhancer 1 (sprot)

description: A DAP3-binding cell death enhancer 1 that is encoded in the genome of human.


response to iron ion starvation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion.


name: ARHG7_HUMAN Rho guanine nucleotide exchange factor 7 (sprot)

description: A Rho guanine nucleotide exchange factor 7 that is encoded in the genome of human.


name: negative regulation of microtubule nucleation

description: Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation.


name: EFR3A_HUMAN Protein EFR3 homolog A (sprot)

description: A protein EFR3 homolog A that is encoded in the genome of human.


name: UBP2L_HUMAN Ubiquitin-associated protein 2-like (sprot)

description: A ubiquitin-associated protein 2-like that is encoded in the genome of human.


name: SPIDR_HUMAN DNA repair-scaffolding protein (sprot)

description: A DNA repair-scaffolding protein that is encoded in the genome of human.


name: regulation of establishment of protein localization to chromosome

description: Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome.


name: SCRIB_HUMAN Protein scribble homolog (sprot)

description: A protein LAP4 that is encoded in the genome of human.


name: GIT2_HUMAN ARF GTPase-activating protein GIT2 (sprot)

description: An ARF GTPase-activating protein GIT2 that is encoded in the genome of human.


name: SREC_HUMAN Scavenger receptor class F member 1 (sprot)

description: A scavenger receptor class F member 1 that is encoded in the genome of human.


name: IKKE_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit epsilon (sprot)

description: An inhibitor of nuclear factor kappa-B kinase subunit epsilon that is encoded in the genome of human.


MLEC_HUMAN Malectin (sprot)

A malectin that is encoded in the genome of human.


name: TTL12_HUMAN Tubulin--tyrosine ligase-like protein 12 (sprot)

description: A tubulin--tyrosine ligase-like protein 12 that is encoded in the genome of human.


tubulin-tyrosine ligase activity

description: Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.


name: histone H4K20 trimethyltransferase activity

description: Catalysis of the reaction: L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H+ + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine. This reaction is the addition of three methyl groups to the lysine residue at position 20 of the histone H4 protein, producing histone H4K20me3.


name: MPP2_HUMAN MAGUK p55 subfamily member 2 (sprot)

description: A MAGUK p55 subfamily member 2 that is encoded in the genome of human.


name: DPOA2_HUMAN DNA polymerase alpha subunit B (sprot)

description: A DNA polymerase alpha subunit B that is encoded in the genome of human.


name: DOC2A_HUMAN Double C2-like domain-containing protein alpha (sprot)

description: A double C2-like domain-containing protein alpha that is encoded in the genome of human.


name: DOC2B_HUMAN Double C2-like domain-containing protein beta (sprot)

description: A double C2-like domain-containing protein beta that is encoded in the genome of human.


name: DOCK1_HUMAN Dedicator of cytokinesis protein 1 (sprot)

description: A dedicator of cytokinesis protein 1 that is encoded in the genome of human.


name: TFDP1_HUMAN Transcription factor Dp-1 (sprot)

description: A transcription factor Dp-1 that is encoded in the genome of human.


name: TFDP2_HUMAN Transcription factor Dp-2 (sprot)

description: A transcription factor Dp-2 that is encoded in the genome of human.


name: SIM2_HUMAN Single-minded homolog 2 (sprot)

description: A single-minded homolog 2 that is encoded in the genome of human.


name: WRN_HUMAN Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (sprot)

description: A bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN that is encoded in the genome of human.


3'-flap-structured DNA binding

description: Binding to a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule.


regulation of growth rate

description: Any process that modulates the rate of growth of all or part of an organism.


positive regulation of strand invasion

description: Any process that increases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.


name: FHL2_HUMAN Four and a half LIM domains protein 2 (sprot)

description: A four and a half LIM domains protein 2 that is encoded in the genome of human.


name: DPYL1_HUMAN Dihydropyrimidinase-related protein 1 (sprot)

description: A dihydropyrimidinase-related protein 1 that is encoded in the genome of human.


name: DPYL3_HUMAN Dihydropyrimidinase-related protein 3 (sprot)

description: A dihydropyrimidinase-related protein 3 that is encoded in the genome of human.


name: ICT1_HUMAN Large ribosomal subunit protein mL62 (sprot)

description: An immature colon carcinoma transcript 1 protein that is encoded in the genome of human.


name: translation release factor activity, codon nonspecific

description: A translation release factor that is not specific to particular codons; binds to guanine nucleotides.


BTG3_HUMAN Protein BTG3 (sprot)

A protein BTG3 that is encoded in the genome of human.


name: ZMYM3_HUMAN Zinc finger MYM-type protein 3 (sprot)

description: A zinc finger MYM-type protein 3 that is encoded in the genome of human.


DCTN1_HUMAN Dynactin subunit 1 (sprot)

A dynactin subunit 1 that is encoded in the genome of human.


centriole-centriole cohesion

description: The cell cycle process in which the two centrioles within a centrosome remain tightly paired.


microtubule anchoring at centrosome

description: Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome.


name: positive regulation of neuromuscular junction development

description: Any process that activates or increases the frequency, rate or extent of neuromuscular junction development.


name: DYHC1_HUMAN Cytoplasmic dynein 1 heavy chain 1 (sprot)

description: A cytoplasmic dynein 1 heavy chain 1 that is encoded in the genome of human.


name: minus-end-directed microtubule motor activity

description: A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis.


name: positive regulation of intracellular transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.


name: regulation of metaphase plate congression

description: Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle.


RCAN2_HUMAN Calcipressin-2 (sprot)

A calcipressin-2 that is encoded in the genome of human.


NPAT_HUMAN Protein NPAT (sprot)

A protein NPAT that is encoded in the genome of human.


name: E2F2_HUMAN Transcription factor E2F2 (sprot)

description: A transcription factor E2F2 that is encoded in the genome of human.


name: LY6D_HUMAN Lymphocyte antigen 6D (sprot)

description: A lymphocyte antigen 6D that is encoded in the genome of human.


name: IL27B_HUMAN Interleukin-27 subunit beta (sprot)

description: An interleukin-27 subunit beta that is encoded in the genome of human.


interleukin-27 receptor binding

description: Binding to an interleukin-27 receptor.


name: EI2BA_HUMAN Translation initiation factor eIF2B subunit alpha (sprot)

description: A translation initiation factor eIF2B subunit alpha that is encoded in the genome of human.


name: EPAG_HUMAN Early lymphoid activation gene protein (sprot)

description: An early lymphoid activation gene protein that is encoded in the genome of human.


name: IF4A2_HUMAN Eukaryotic initiation factor 4A-II (sprot)

description: A eukaryotic initiation factor 4A-II that is encoded in the genome of human.


name: negative regulation of RNA-dependent RNA polymerase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity.


ELOA1_HUMAN Elongin-A (sprot)

An elongin-A that is encoded in the genome of human.


name: SELPL_HUMAN P-selectin glycoprotein ligand 1 (sprot)

description: A P-selectin glycoprotein ligand 1 that is encoded in the genome of human.


MAP7_HUMAN Ensconsin (sprot)

An ensconsin that is encoded in the genome of human.


name: AGRE1_HUMAN Adhesion G protein-coupled receptor E1 (sprot)

description: An adhesion G protein-coupled receptor E1 that is encoded in the genome of human.


name: SRC8_HUMAN Src substrate cortactin (sprot)

description: A Src substrate cortactin that is encoded in the genome of human.


lamellipodium organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.


name: NUCG_HUMAN Endonuclease G, mitochondrial (sprot)

description: An endonuclease G, mitochondrial that is encoded in the genome of human.


mitochondrial DNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA.


FLOT2_HUMAN Flotillin-2 (sprot)

A flotillin-2 that is encoded in the genome of human.


anterograde dendritic transport

description: The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites.


RCN2_HUMAN Reticulocalbin-2 (sprot)

A reticulocalbin-2 that is encoded in the genome of human.


name: TRI25_HUMAN E3 ubiquitin/ISG15 ligase TRIM25 (sprot)

description: An E3 ubiquitin/ISG15 ligase TRIM25 that is encoded in the genome of human.


RIG-I binding

description: Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA.


name: regulation of viral entry into host cell

description: Any process that modulates the frequency, rate or extent of the viral entry into the host cell.


name: ENR1_HUMAN Endogenous retrovirus group 3 member 1 Env polyprotein (sprot)

description: An endogenous retrovirus group 3 member 1 Env polyprotein that is encoded in the genome of human.


name: FAK2_HUMAN Protein-tyrosine kinase 2-beta (sprot)

description: A focal adhesion kinase 2 that is encoded in the genome of human.


name: 3-phosphoinositide-dependent protein kinase binding

description: Binding to a 3-phosphoinositide-dependent protein kinase.


name: neurotransmitter receptor regulator activity

description: A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing.


regulation of macrophage chemotaxis

description: Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.


response to cation stress

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment.


name: FASTK_HUMAN Fas-activated serine/threonine kinase (sprot)

description: A Fas-activated serine/threonine kinase that is encoded in the genome of human.


name: Fas-activated serine/threonine kinase activity

description: Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein.


FGL2_HUMAN Fibroleukin (sprot)

A fibroleukin that is encoded in the genome of human.


name: negative regulation of macrophage antigen processing and presentation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation.


name: negative regulation of memory T cell differentiation

description: Any process that stops, prevents, or reduces the rate of memory T cell differentiation.


FLNC_HUMAN Filamin-C (sprot)

A filamin-C that is encoded in the genome of human.


name: FKBP8_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP8 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP8 that is encoded in the genome of human.


FA50A_HUMAN Protein FAM50A (sprot)

A protein FAM50A that is encoded in the genome of human.


name: MYPC2_HUMAN Myosin-binding protein C, fast-type (sprot)

description: A myosin-binding protein C, fast-type that is encoded in the genome of human.


name: GPR18_HUMAN N-arachidonyl glycine receptor (sprot)

description: An N-arachidonyl glycine receptor that is encoded in the genome of human.


name: CD8-positive, alpha-beta intraepithelial T cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.


FRG1_HUMAN Protein FRG1 (sprot)

A protein FRG1 that is encoded in the genome of human.


FZD2_HUMAN Frizzled-2 (sprot)

A frizzled-2 that is encoded in the genome of human.


name: GNA13_HUMAN Guanine nucleotide-binding protein subunit alpha-13 (sprot)

description: A guanine nucleotide-binding protein subunit alpha-13 that is encoded in the genome of human.


name: GAMT_HUMAN Guanidinoacetate N-methyltransferase (sprot)

description: A guanidinoacetate N-methyltransferase that is encoded in the genome of human.


description: Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H+.


name: GALE_HUMAN UDP-glucose 4-epimerase (sprot)

description: A UDP-glucose 4-epimerase that is encoded in the genome of human.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine.


UDP-glucose 4-epimerase activity

description: Catalysis of the reaction: UDP-glucose = UDP-galactose.


name: GGTL2_HUMAN Glutathione hydrolase light chain 2 (sprot)

description: A glutathione hydrolase light chain 2 that is encoded in the genome of human.


name: LRC32_HUMAN Transforming growth factor beta activator LRRC32 (sprot)

description: A transforming growth factor beta activator LRRC32 that is encoded in the genome of human.


name: establishment of protein localization to extracellular region

description: The directed movement of a protein to a specific location within the extracellular region.


name: GAS6_HUMAN Growth arrest-specific protein 6 (sprot)

description: A growth arrest-specific protein 6 that is encoded in the genome of human.


cellular response to vitamin K

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus.


name: negative regulation of oligodendrocyte apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process.


name: negative regulation of renal albumin absorption

description: Any process that stops, prevents or reduces the frequency, rate or extent of renal albumin absorption.


name: GCKR_HUMAN Glucokinase regulatory protein (sprot)

description: A glucokinase regulatory protein that is encoded in the genome of human.


name: carbohydrate derivative metabolic process

description: The chemical reactions and pathways involving carbohydrate derivative.


name: CSHL_HUMAN Chorionic somatomammotropin hormone-like 1 (sprot)

description: A chorionic somatomammotropin hormone-like 1 that is encoded in the genome of human.


GLPK3_HUMAN Glycerol kinase 3 (sprot)

A glycerol kinase 3 that is encoded in the genome of human.


GLPK2_HUMAN Glycerol kinase 2 (sprot)

A glycerol kinase 2 that is encoded in the genome of human.


sperm mitochondrial sheath assembly

description: The assembly and organization of the sperm mitochondrial sheath, the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum.


name: GRM2_HUMAN Metabotropic glutamate receptor 2 (sprot)

description: A metabotropic glutamate receptor 2 that is encoded in the genome of human.


regulation of response to drug

description: Any process that modulates the frequency, rate or extent of response to drug.


name: PDE3A_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (sprot)

description: A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A that is encoded in the genome of human.


estrogen binding

description: Binding to an estrogen.


name: GALT3_HUMAN Polypeptide N-acetylgalactosaminyltransferase 3 (sprot)

description: A polypeptide N-acetylgalactosaminyltransferase 3 that is encoded in the genome of human.


name: GP176_HUMAN G-protein coupled receptor 176 (sprot)

description: A G-protein coupled receptor 176 that is encoded in the genome of human.


name: PIGH_HUMAN Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (sprot)

description: A phosphatidylinositol N-acetylglucosaminyltransferase subunit H that is encoded in the genome of human.


CAPR1_HUMAN Caprin-1 (sprot)

A caprin-1 that is encoded in the genome of human.


name: regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA

description: Any process that modulates the frequency, rate or extent of deadenylation-dependent decapping of nuclear-transcribed mRNA.


name: GRB14_HUMAN Growth factor receptor-bound protein 14 (sprot)

description: A growth factor receptor-bound protein 14 that is encoded in the genome of human.


name: GRB7_HUMAN Growth factor receptor-bound protein 7 (sprot)

description: A growth factor receptor-bound protein 7 that is encoded in the genome of human.


BECN1_HUMAN Beclin-1 (sprot)

A beclin-1 that is encoded in the genome of human.


suppression by virus of host autophagy

description: Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host.


cellular response to aluminum ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus.


name: cytoplasmic side of mitochondrial outer membrane

description: The external (cytoplasmic) face of the mitochondrial outer membrane.


name: phosphatidylinositol 3-kinase complex, class III

description: A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI).


name: HES1_HUMAN Transcription factor HES-1 (sprot)

description: A transcription factor HES-1 that is encoded in the genome of human.


N-box binding

description: Binding to an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses.


trochlear nerve development

description: The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle.


hindbrain morphogenesis

description: The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.


name: positive regulation of mitotic cell cycle, embryonic

description: Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle.


name: regulation of timing of neuron differentiation

description: The process controlling the activation and/or rate at which a relatively unspecialized cell acquires features of a neuron.


common bile duct development

description: The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine.


name: negative regulation of stomach neuroendocrine cell differentiation

description: Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.


name: renal interstitial fibroblast development

description: The process whose specific outcome is the progression of a renal interstitial fibroblast over time, from its formation to the mature structure.


name: metanephric nephron tubule morphogenesis

description: The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros.


name: negative regulation of cell fate determination

description: Any process that stops, prevents or reduces the frequency, rate or extent of cell fate determination.


name: negative regulation of pancreatic A cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation.


name: SLBP_HUMAN Histone RNA hairpin-binding protein (sprot)

description: A histone RNA hairpin-binding protein that is encoded in the genome of human.


histone pre-mRNA stem-loop binding

description: Binding to a conserved stem-loop structure found in histone pre-mRNAs.


name: NF2L1_HUMAN Endoplasmic reticulum membrane sensor NFE2L1 (sprot)

description: An endoplasmic reticulum membrane sensor NFE2L1 that is encoded in the genome of human.


name: RBM39_HUMAN RNA-binding protein 39 (sprot)

description: An RNA-binding protein 39 that is encoded in the genome of human.


name: KCJ12_HUMAN ATP-sensitive inward rectifier potassium channel 12 (sprot)

description: An ATP-sensitive inward rectifier potassium channel 12 that is encoded in the genome of human.


name: EP3A_HUMAN Epididymal secretory protein E3-alpha (sprot)

description: An epididymal secretory protein E3-alpha that is encoded in the genome of human.


sperm displacement

description: The physical displacement of sperm stored from previous mating encounters.


name: WFDC2_HUMAN WAP four-disulfide core domain protein 2 (sprot)

description: A WAP four-disulfide core domain protein 2 that is encoded in the genome of human.


name: CASL_HUMAN Enhancer of filamentation 1 (sprot)

description: An enhancer of filamentation 1 that is encoded in the genome of human.


name: positive regulation of lymphocyte chemotaxis

description: Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis.


name: FGFP1_HUMAN Fibroblast growth factor-binding protein 1 (sprot)

description: A fibroblast growth factor-binding protein 1 that is encoded in the genome of human.


name: SPRL1_HUMAN SPARC-like protein 1 (sprot)

description: A SPARC-like protein 1 that is encoded in the genome of human.


FAT1_HUMAN Protocadherin Fat 1 (sprot)

A protocadherin Fat 1 that is encoded in the genome of human.


name: establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis

description: The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye.


name: HABP2_HUMAN Hyaluronan-binding protein 2 (sprot)

description: A hyaluronan-binding protein 2 that is encoded in the genome of human.


name: SCN5A_HUMAN Sodium channel protein type 5 subunit alpha (sprot)

description: A sodium channel protein type 5 subunit alpha that is encoded in the genome of human.


name: voltage-gated sodium channel activity involved in AV node cell action potential

description: Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: voltage-gated sodium channel activity involved in bundle of His cell action potential

description: Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: voltage-gated sodium channel activity involved in SA node cell action potential

description: Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


bundle of His cell action potential

description: An action potential that occurs in a bundle of His cell.


name: KT33B_HUMAN Keratin, type I cuticular Ha3-II (sprot)

description: A keratin, type I cuticular Ha3-II that is encoded in the genome of human.


name: HIC1_HUMAN Hypermethylated in cancer 1 protein (sprot)

description: A hypermethylated in cancer 1 protein that is encoded in the genome of human.


name: HLTF_HUMAN Helicase-like transcription factor (sprot)

description: A helicase-like transcription factor that is encoded in the genome of human.


name: K1H2_HUMAN Keratin, type I cuticular Ha2 (sprot)

description: A keratin, type I cuticular Ha2 that is encoded in the genome of human.


name: KRT81_HUMAN Keratin, type II cuticular Hb1 (sprot)

description: A keratin, type II cuticular Hb1 that is encoded in the genome of human.


name: ERG1_HUMAN Squalene monooxygenase (sprot)

description: A squalene monooxygenase that is encoded in the genome of human.


squalene monooxygenase activity

description: Catalysis of the reaction: H+ + NADPH + O2 + squalene = (S)-2,3-epoxysqualene + H2O + NADP+.


sterol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


name: HNF4G_HUMAN Hepatocyte nuclear factor 4-gamma (sprot)

description: A hepatocyte nuclear factor 4-gamma that is encoded in the genome of human.


name: S29A2_HUMAN Equilibrative nucleoside transporter 2 (sprot)

description: An equilibrative nucleoside transporter 2 that is encoded in the genome of human.


name: nucleoside transmembrane transporter activity

description: Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other.


name: nucleobase transmembrane transporter activity

description: Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other.


name: guanine transmembrane transporter activity

description: Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other.


name: uracil transmembrane transporter activity

description: Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other.


nucleobase transport

description: The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


nucleoside transport

description: The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


hypoxanthine transport

description: The directed movement of hypoxanthine, 6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


thymine transport

description: The directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


guanine transmembrane transport

description: The process in which guanine is transported across a membrane.


uracil transmembrane transport

description: The process in which uracil is transported across a membrane.


name: GBX1_HUMAN Homeobox protein GBX-1 (sprot)

description: A homeobox protein GBX-1 that is encoded in the genome of human.


name: PDIA5_HUMAN Protein disulfide-isomerase A5 (sprot)

description: A protein disulfide-isomerase A5 that is encoded in the genome of human.


name: KPRA_HUMAN Phosphoribosyl pyrophosphate synthase-associated protein 1 (sprot)

description: A phosphoribosyl pyrophosphate synthase-associated protein 1 that is encoded in the genome of human.


name: DHX8_HUMAN ATP-dependent RNA helicase DHX8 (sprot)

description: An ATP-dependent RNA helicase DHX8 that is encoded in the genome of human.


SEM3A_HUMAN Semaphorin-3A (sprot)

A semaphorin-3A that is encoded in the genome of human.


name: regulation of axon extension involved in axon guidance

description: Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance.


name: DMC1_HUMAN Meiotic recombination protein DMC1/LIM15 homolog (sprot)

description: A meiotic recombination protein DMC1/LIM15 that is encoded in the genome of human.


name: MCM6_HUMAN DNA replication licensing factor MCM6 (sprot)

description: A DNA replication licensing factor MCM6 that is encoded in the genome of human.


name: HS902_HUMAN Heat shock protein HSP 90-alpha A2 (sprot)

description: A heat shock protein HSP 90-alpha A2 that is encoded in the genome of human.


name: regulation of macromolecule metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.


name: ITPR2_HUMAN Inositol 1,4,5-trisphosphate receptor type 2 (sprot)

description: An inositol 1,4,5-trisphosphate receptor type 2 that is encoded in the genome of human.


name: inositol 1,4,5-trisphosphate-gated calcium channel activity

description: Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts.


name: ITPR3_HUMAN Inositol 1,4,5-trisphosphate receptor type 3 (sprot)

description: An inositol 1,4,5-trisphosphate receptor type 3 that is encoded in the genome of human.


inositol hexakisphosphate binding

description: Binding to inositol hexakisphosphate.


sensory perception of sweet taste

description: The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


DSC3_HUMAN Desmocollin-3 (sprot)

A desmocollin-3 that is encoded in the genome of human.


ELAV3_HUMAN ELAV-like protein 3 (sprot)

An ELAV-like protein 3 that is encoded in the genome of human.


name: MAD4_HUMAN Max dimerization protein 4 (sprot)

description: A max dimerization protein 4 that is encoded in the genome of human.


name: ZN266_HUMAN Zinc finger protein 266 (sprot)

description: A zinc finger protein 266 that is encoded in the genome of human.


name: ZN345_HUMAN Zinc finger protein 345 (sprot)

description: A zinc finger protein 345 that is encoded in the genome of human.


name: ZN267_HUMAN Zinc finger protein 267 (sprot)

description: A zinc finger protein 267 that is encoded in the genome of human.


name: ZN268_HUMAN Zinc finger protein 268 (sprot)

description: A zinc finger protein 268 that is encoded in the genome of human.


name: ZN234_HUMAN Zinc finger protein 234 (sprot)

description: A zinc finger protein 234 that is encoded in the genome of human.


name: ZN235_HUMAN Zinc finger protein 235 (sprot)

description: A zinc finger protein 235 that is encoded in the genome of human.


name: ZN460_HUMAN Zinc finger protein 460 (sprot)

description: A zinc finger protein 460 that is encoded in the genome of human.


name: ZN273_HUMAN Zinc finger protein 273 (sprot)

description: A zinc finger protein 273 that is encoded in the genome of human.


name: NBR1_HUMAN Next to BRCA1 gene 1 protein (sprot)

description: A next to BRCA1 gene 1 protein that is encoded in the genome of human.


name: ID2B_HUMAN Putative DNA-binding protein inhibitor ID-2B (sprot)


name: IHH_HUMAN Indian hedgehog protein (sprot)

description: An Indian hedgehog protein that is encoded in the genome of human.


intein-mediated protein splicing

description: The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues.


vitelline membrane formation

description: Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg.


negative regulation of eye pigmentation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism.


name: camera-type eye photoreceptor cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell in a camera-type eye.


name: ITIH4_HUMAN Inter-alpha-trypsin inhibitor heavy chain H4 (sprot)

description: An inter-alpha-trypsin inhibitor heavy chain H4 that is encoded in the genome of human.


name: I11RA_HUMAN Interleukin-11 receptor subunit alpha (sprot)

description: An interleukin-11 receptor subunit alpha that is encoded in the genome of human.


developmental process

description: A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.


name: I13R2_HUMAN Interleukin-13 receptor subunit alpha-2 (sprot)

description: An interleukin-13 receptor subunit alpha-2 that is encoded in the genome of human.


name: INSL4_HUMAN Early placenta insulin-like peptide (sprot)

description: An early placenta insulin-like peptide that is encoded in the genome of human.


name: positive regulation of chorionic trophoblast cell proliferation

description: Any process that activates or increases the frequency, rate or extent of chorionic trophoblast cell proliferation.


name: I5P1_HUMAN Inositol polyphosphate-5-phosphatase A (sprot)

description: An inositol polyphosphate-5-phosphatase A that is encoded in the genome of human.


name: negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway.


name: ITPR1_HUMAN Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (sprot)

description: An inositol 1,4,5-trisphosphate receptor type 1 that is encoded in the genome of human.


name: inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

description: Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.


name: RASA3_HUMAN Ras GTPase-activating protein 3 (sprot)

description: A Ras GTPase-activating protein 3 that is encoded in the genome of human.


PLSI_HUMAN Plastin-1 (sprot)

A plastin-1 that is encoded in the genome of human.


name: vestibular receptor cell stereocilium organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells.


name: IRF3_HUMAN Interferon regulatory factor 3 (sprot)

description: An interferon regulatory factor 3 that is encoded in the genome of human.


MDA-5 signaling pathway

description: The series of molecular signals initiated by the binding of dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.


cGAS/STING signaling pathway

description: The series of molecular signals initiated by the binding of a double-stranded DNA or RNA from another organism to cytosolic cyclic GMP-AMP (cGAMP) synthase (cGAS) that activates innate immune responses through production of the second messenger cGAMP, which activates the adaptor STING.


name: KCJ11_HUMAN ATP-sensitive inward rectifier potassium channel 11 (sprot)

description: An ATP-sensitive inward rectifier potassium channel 11 that is encoded in the genome of human.


response to resveratrol

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus.


name: TM187_HUMAN Transmembrane protein 187 (sprot)

description: A transmembrane protein 187 that is encoded in the genome of human.


name: LAGE3_HUMAN EKC/KEOPS complex subunit LAGE3 (sprot)

description: An EKC/KEOPS complex subunit LAGE3 that is encoded in the genome of human.


EKC/KEOPS complex

description: A protein complex involved in t6A tRNA modification. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p.


name: BLTP2_HUMAN Bridge-like lipid transfer protein family member 2 (sprot)

description: A bridge-like lipid transfer protein family member 2 that is encoded in the genome of human.


name: TRIPC_HUMAN E3 ubiquitin-protein ligase TRIP12 (sprot)

description: An E3 ubiquitin-protein ligase TRIP12 that is encoded in the genome of human.


PUM1_HUMAN Pumilio homolog 1 (sprot)

A pumilio homolog 1 that is encoded in the genome of human.


name: regulation of miRNA-mediated gene silencing

description: A process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs).


ESPL1_HUMAN Separin (sprot)

A separin that is encoded in the genome of human.


name: establishment of mitotic spindle localization

description: The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs.


name: negative regulation of sister chromatid cohesion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion.


name: MDC1_HUMAN Mediator of DNA damage checkpoint protein 1 (sprot)

description: A mediator of DNA damage checkpoint protein 1 that is encoded in the genome of human.


name: EPN4_HUMAN Clathrin interactor 1 (sprot)

description: A clathrin interactor 1 that is encoded in the genome of human.


name: KANK1_HUMAN KN motif and ankyrin repeat domain-containing protein 1 (sprot)

description: A KN motif and ankyrin repeat domain-containing protein 1 that is encoded in the genome of human.


name: negative regulation of lamellipodium morphogenesis

description: Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium morphogenesis.


name: TTLL4_HUMAN Tubulin monoglutamylase TTLL4 (sprot)

description: A tubulin monoglutamylase TTLL4 that is encoded in the genome of human.


protein-glutamic acid ligase activity

description: Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein.


peptidyl-glutamic acid modification

description: The modification of peptidyl-glutamic acid.


name: MELK_HUMAN Maternal embryonic leucine zipper kinase (sprot)

description: A maternal embryonic leucine zipper kinase that is encoded in the genome of human.


name: KCTD2_HUMAN BTB/POZ domain-containing protein KCTD2 (sprot)

description: A BTB/POZ domain-containing protein KCTD2 that is encoded in the genome of human.


name: SMC1A_HUMAN Structural maintenance of chromosomes protein 1A (sprot)

description: A structural maintenance of chromosomes protein 1A that is encoded in the genome of human.


name: RRP1B_HUMAN Ribosomal RNA processing protein 1 homolog B (sprot)

description: A ribosomal RNA processing protein 1 homolog B that is encoded in the genome of human.


name: NCOA6_HUMAN Nuclear receptor coactivator 6 (sprot)

description: A nuclear receptor coactivator 6 that is encoded in the genome of human.


name: GSE1_HUMAN Genetic suppressor element 1 (sprot)

description: A genetic suppressor element 1 that is encoded in the genome of human.


name: DIP2A_HUMAN Disco-interacting protein 2 homolog A (sprot)

description: A disco-interacting protein 2 homolog A that is encoded in the genome of human.


acetate-CoA ligase activity

description: Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.


RRP5_HUMAN Protein RRP5 homolog (sprot)

A protein RRP5 that is encoded in the genome of human.


name: PSF1_HUMAN DNA replication complex GINS protein PSF1 (sprot)

description: A DNA replication complex GINS protein PSF1 that is encoded in the genome of human.


GINS complex

description: A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.


name: BMS1_HUMAN Ribosome biogenesis protein BMS1 homolog (sprot)

description: A ribosome biogenesis protein BMS1 that is encoded in the genome of human.


name: LPIN1_HUMAN Phosphatidate phosphatase LPIN1 (sprot)

description: A phosphatidate phosphatase LPIN1 that is encoded in the genome of human.


triglyceride mobilization

description: The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism.


name: UBP10_HUMAN Ubiquitin carboxyl-terminal hydrolase 10 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 10 that is encoded in the genome of human.


name: negative regulation of stress granule assembly

description: Any process that stops or decreases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.


MESD_HUMAN LRP chaperone MESD (sprot)

A mesoderm development candidate 2 that is encoded in the genome of human.


name: GANAB_HUMAN Neutral alpha-glucosidase AB (sprot)

description: A neutral alpha-glucosidase AB that is encoded in the genome of human.


glucan 1,3-alpha-glucosidase activity

description: Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans.


RFTN1_HUMAN Raftlin (sprot)

A raftlin that is encoded in the genome of human.


protein transport into membrane raft

description: The directed movement of a protein into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.


positive regulation of growth rate

description: Any process that increases the rate of growth of all or part of an organism.


protein localization to membrane raft

description: A process in which a protein is transported to, or maintained in, a location within a membrane raft.


name: MBTP1_HUMAN Membrane-bound transcription factor site-1 protease (sprot)

description: A membrane-bound transcription factor site-1 protease that is encoded in the genome of human.


SSPN_HUMAN Sarcospan (sprot)

A sarcospan that is encoded in the genome of human.


name: KCNB1_HUMAN Potassium voltage-gated channel subfamily B member 1 (sprot)

description: A voltage-gated potassium channel KCNB1 that is encoded in the genome of human.


name: KCAB1_HUMAN Voltage-gated potassium channel subunit beta-1 (sprot)

description: A voltage-gated potassium channel subunit beta-1 that is encoded in the genome of human.


name: MFS10_HUMAN Major facilitator superfamily domain-containing protein 10 (sprot)

description: A major facilitator superfamily domain-containing protein 10 that is encoded in the genome of human.


name: tetracycline transmembrane transporter activity

description: Enables the transfer of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles).


tetracycline transmembrane transport

description: The directed movement of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles).


name: 2A5D_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (sprot)

description: A serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform that is encoded in the genome of human.


name: LBR_HUMAN Delta(14)-sterol reductase LBR (sprot)

description: A Delta(14)-sterol reductase LBR that is encoded in the genome of human.


name: COG2_HUMAN Conserved oligomeric Golgi complex subunit 2 (sprot)

description: A conserved oligomeric Golgi complex subunit 2 that is encoded in the genome of human.


name: GNMT_HUMAN Glycine N-methyltransferase (sprot)

description: A glycine N-methyltransferase that is encoded in the genome of human.


glycine N-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.


name: PTCA_HUMAN Protein tyrosine phosphatase receptor type C-associated protein (sprot)

description: A protein tyrosine phosphatase receptor type C-associated protein that is encoded in the genome of human.


MVP_HUMAN Major vault protein (sprot)

A major vault protein that is encoded in the genome of human.


protein activation cascade

description: A sequential series of modifications to a set of proteins where the product of one reaction catalyzes the following reaction, ultimately leading to the generation of a mature protein. Modifications typically include proteolysis or covalent modification, and may also include binding events.


name: STAT4_HUMAN Signal transducer and activator of transcription 4 (sprot)

description: A signal transducer and activator of transcription 4 that is encoded in the genome of human.


name: LTBP1_HUMAN Latent-transforming growth factor beta-binding protein 1 (sprot)

description: A latent TGF-beta-binding protein 1 that is encoded in the genome of human.


name: LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2 (sprot)

description: A latent-transforming growth factor beta-binding protein 2 that is encoded in the genome of human.


name: ICAM4_HUMAN Intercellular adhesion molecule 4 (sprot)

description: An intercellular adhesion molecule 4 that is encoded in the genome of human.


name: HLX_HUMAN H2.0-like homeobox protein (sprot)

description: An H2.0-like homeobox protein that is encoded in the genome of human.


name: CBX2_HUMAN Chromobox protein homolog 2 (sprot)

description: A chromobox protein homolog 2 that is encoded in the genome of human.


name: development of primary sexual characteristics

description: The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion.


name: GOGB1_HUMAN Golgin subfamily B member 1 (sprot)

description: A golgin subfamily B member 1 that is encoded in the genome of human.


name: protein localization to pericentriolar material

description: A process in which a protein is transported to, or maintained in, a location within a pericentriolar material.


CASP8_HUMAN Caspase-8 (sprot)

A caspase-8 that is encoded in the genome of human.


name: ZN846_HUMAN Zinc finger protein 846 (sprot)

description: A zinc finger protein 846 that is encoded in the genome of human.


name: SMCO1_HUMAN Single-pass membrane and coiled-coil domain-containing protein 1 (sprot)

description: A single-pass membrane and coiled-coil domain-containing protein 1 that is encoded in the genome of human.


name: NAA30_HUMAN N-alpha-acetyltransferase 30 (sprot)

description: An N-acetyltransferase MAK3 that is encoded in the genome of human.


NatC complex

description: A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p.


name: FXYD3_HUMAN FXYD domain-containing ion transport regulator 3 (sprot)

description: An FXYD domain-containing ion transport regulator 3 that is encoded in the genome of human.


name: KIF22_HUMAN Kinesin-like protein KIF22 (sprot)

description: A kinesin-like protein KIF22 that is encoded in the genome of human.


name: MEF2D_HUMAN Myocyte-specific enhancer factor 2D (sprot)

description: A myocyte-specific enhancer factor 2D that is encoded in the genome of human.


name: GRM7_HUMAN Metabotropic glutamate receptor 7 (sprot)

description: A metabotropic glutamate receptor 7 that is encoded in the genome of human.


name: group III metabotropic glutamate receptor activity

description: A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity.


name: GRM3_HUMAN Metabotropic glutamate receptor 3 (sprot)

description: A metabotropic glutamate receptor 3 that is encoded in the genome of human.


name: GRM4_HUMAN Metabotropic glutamate receptor 4 (sprot)

description: A metabotropic glutamate receptor 4 that is encoded in the genome of human.


name: CHD4_HUMAN Chromodomain-helicase-DNA-binding protein 4 (sprot)

description: A chromodomain-helicase-DNA-binding protein 4 that is encoded in the genome of human.


name: LASP1_HUMAN LIM and SH3 domain protein 1 (sprot)

description: A LIM and SH3 domain protein 1 that is encoded in the genome of human.


name: STAR3_HUMAN StAR-related lipid transfer protein 3 (sprot)

description: A StAR-related lipid transfer protein 3 that is encoded in the genome of human.


name: PO6F1_HUMAN POU domain, class 6, transcription factor 1 (sprot)

description: A POU domain, class 6, transcription factor 1 that is encoded in the genome of human.


name: ARI5B_HUMAN AT-rich interactive domain-containing protein 5B (sprot)

description: An AT-rich interactive domain-containing protein 5B that is encoded in the genome of human.


name: MTF1_HUMAN Metal regulatory transcription factor 1 (sprot)

description: A metal regulatory transcription factor 1 that is encoded in the genome of human.


name: CRYM_HUMAN Ketimine reductase mu-crystallin (sprot)

description: A ketimine reductase mu-crystallin that is encoded in the genome of human.


description: Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate.


name: MYPC3_HUMAN Myosin-binding protein C, cardiac-type (sprot)

description: A myosin-binding protein C, cardiac-type that is encoded in the genome of human.


regulation of muscle filament sliding

description: Any process that modulates the frequency, rate or extent of muscle filament sliding.


C zone

description: A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin.


name: PTGR1_HUMAN Prostaglandin reductase 1 (sprot)

description: A prostaglandin reductase 1 that is encoded in the genome of human.


2-alkenal reductase (NADPH) activity

description: Catalysis of the reaction: n-alkanal + NADP+ = alk-2-enal + NADPH + H+.


13-prostaglandin reductase activity

description: Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin.


13-lipoxin reductase activity

description: Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+.


name: leukotriene B4 12-hydroxy dehydrogenase activity

description: Catalysis of the reaction: leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + NADPH + H+.


leukotriene B4 metabolic process

description: The chemical reactions and pathways involving leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.


lipoxin A4 metabolic process

description: The chemical reactions and pathways involving lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds.


name: NPT1_HUMAN Sodium-dependent phosphate transport protein 1 (sprot)

description: A sodium-dependent phosphate transport protein 1 that is encoded in the genome of human.


name: phosphate transmembrane transporter activity

description: Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.


sodium-dependent phosphate transport

description: The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions.


name: NC2A_HUMAN Dr1-associated corepressor (sprot)

description: A Dr1-associated corepressor that is encoded in the genome of human.


name: ZN169_HUMAN Zinc finger protein 169 (sprot)

description: A zinc finger protein 169 that is encoded in the genome of human.


name: NFAC4_HUMAN Nuclear factor of activated T-cells, cytoplasmic 4 (sprot)

description: A nuclear factor of activated T-cells, cytoplasmic 4 that is encoded in the genome of human.


name: NFIX_HUMAN Nuclear factor 1 X-type (sprot)

description: A nuclear factor 1 X-type that is encoded in the genome of human.


name: SL9A5_HUMAN Sodium/hydrogen exchanger 5 (sprot)

description: A sodium/hydrogen exchanger 5 that is encoded in the genome of human.


name: KI3S1_HUMAN Killer cell immunoglobulin-like receptor 3DS1 (sprot)

description: A killer cell immunoglobulin-like receptor 3DS1 that is encoded in the genome of human.


name: KI2S3_HUMAN Killer cell immunoglobulin-like receptor 2DS3 (sprot)

description: A killer cell immunoglobulin-like receptor 2DS3 that is encoded in the genome of human.


name: KI2S5_HUMAN Killer cell immunoglobulin-like receptor 2DS5 (sprot)

description: A killer cell immunoglobulin-like receptor 2DS5 that is encoded in the genome of human.


name: HLA-C specific inhibitory MHC class I receptor activity

description: Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte.


name: KI2S1_HUMAN Killer cell immunoglobulin-like receptor 2DS1 (sprot)

description: A killer cell immunoglobulin-like receptor 2DS1 that is encoded in the genome of human.


name: GPNMB_HUMAN Transmembrane glycoprotein NMB (sprot)

description: A transmembrane glycoprotein NMB that is encoded in the genome of human.


name: NMDE3_HUMAN Glutamate receptor ionotropic, NMDA 2C (sprot)

description: A glutamate receptor ionotropic, NMDA 2C that is encoded in the genome of human.


name: RB39A_HUMAN Ras-related protein Rab-39A (sprot)

description: A Ras-related protein Rab-39A that is encoded in the genome of human.


name: ZN638_HUMAN Zinc finger protein 638 (sprot)

description: A zinc finger protein 638 that is encoded in the genome of human.


name: NTCP_HUMAN Hepatic sodium/bile acid cotransporter (sprot)

description: A hepatic sodium/bile acid cotransporter that is encoded in the genome of human.


name: IMB1_HUMAN Importin subunit beta-1 (sprot)

description: An importin subunit beta-1 that is encoded in the genome of human.


name: NOLC1_HUMAN Nucleolar and coiled-body phosphoprotein 1 (sprot)

description: A nucleolar phosphoprotein p130 that is encoded in the genome of human.


name: NUMA1_HUMAN Nuclear mitotic apparatus protein 1 (sprot)

description: A nuclear mitotic apparatus protein 1 that is encoded in the genome of human.


anastral spindle assembly

description: The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the absence of centrosomes. Formation is initiated by the nucleation of microtubules (MTs) in the vicinity of condensed chromatin. MTs then attach to and congress around the chromatin due to activity of microtubule motors. A bipolar spindle is formed by focusing of the terminal ends of the MT array into spindle poles by molecular motors and cross-linking proteins.


name: positive regulation of protein localization to spindle pole body

description: Any process that activates or increases the frequency, rate or extent of protein localization to spindle pole body.


name: positive regulation of mitotic spindle elongation

description: Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation.


cortical microtubule

description: Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol.


cytoplasmic microtubule bundle

description: Any microtubule bundle that is part of a cytoplasm.


name: OPCM_HUMAN Opioid-binding protein/cell adhesion molecule (sprot)

description: An opioid-binding protein/cell adhesion molecule that is encoded in the genome of human.


name: ODFP1_HUMAN Outer dense fiber protein 1 (sprot)

description: An outer dense fiber protein 1 that is encoded in the genome of human.


name: COJA1_HUMAN Collagen alpha-1(XIX) chain (sprot)

description: A collagen alpha-1(XIX) chain that is encoded in the genome of human.