name: positive regulation of apoptotic process involved in morphogenesis

description: Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis.


name: tumor necrosis factor receptor superfamily complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily.


name: GGT1_HUMAN Glutathione hydrolase 1 proenzyme (sprot)

description: A glutathione hydrolase 1 proenzyme that is encoded in the genome of human.


peptidyltransferase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme.


leukotriene-C(4) hydrolase

description: Catalysis of the reaction leukotriene C(4) + H2O= leukotriene D(4) + L-glutamate.


cysteine biosynthetic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.


name: ERCC3_HUMAN General transcription and DNA repair factor IIH helicase/translocase subunit XPB (sprot)

description: A general transcription and DNA repair factor IIH helicase subunit XPB that is encoded in the genome of human.


name: nucleotide-excision repair, DNA duplex unwinding

description: The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage.


name: RO52_HUMAN E3 ubiquitin-protein ligase TRIM21 (sprot)

description: An E3 ubiquitin-protein ligase TRIM21 that is encoded in the genome of human.


cellular response to chemical stress

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress.


name: negative regulation of protein deubiquitination

description: Any process that decreases the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein.


name: TFEB_HUMAN Transcription factor EB (sprot)

description: A transcription factor EB that is encoded in the genome of human.


name: E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase (sprot)

description: An interferon-induced, double-stranded RNA-activated protein kinase that is encoded in the genome of human.


name: eukaryotic translation initiation factor 2alpha kinase activity

description: Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate.


name: regulation of NLRP3 inflammasome complex assembly

description: Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly.


name: FUT1_HUMAN Galactoside alpha-(1,2)-fucosyltransferase 1 (sprot)

description: A galactoside alpha-(1,2)-fucosyltransferase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R.


fucosyltransferase activity

description: Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


alpha-(1,2)-fucosyltransferase activity

description: Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage.


fucosylation

description: The covalent attachment of a fucosyl group to an acceptor molecule.


L-fucose catabolic process

description: The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose).


name: TFE3_HUMAN Transcription factor E3 (sprot)

description: A transcription factor E3 that is encoded in the genome of human.


WT1_HUMAN Wilms tumor protein (sprot)

A Wilms tumor protein that is encoded in the genome of human.


regulation of animal organ formation

description: Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.


name: thorax and anterior abdomen determination

description: Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product.


gonad development

description: The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.


adrenal cortex formation

description: The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate).


visceral serous pericardium development

description: The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.


name: cellular response to gonadotropin stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.


metanephric mesenchyme development

description: The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros.


name: posterior mesonephric tubule development

description: The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros.


metanephric epithelium development

description: The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.


metanephric S-shaped body morphogenesis

description: The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros.


name: negative regulation of metanephric glomerular mesangial cell proliferation

description: Any process that decreases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation.


name: positive regulation of male gonad development

description: Any process that activates or increases the frequency, rate or extent of male gonad development.


name: negative regulation of female gonad development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development.


name: positive regulation of metanephric ureteric bud development

description: Any process that activates or increases the frequency, rate or extent of metanephric ureteric bud development.


name: HME2_HUMAN Homeobox protein engrailed-2 (sprot)

description: A homeobox protein engrailed-2 that is encoded in the genome of human.


SPEE_HUMAN Spermidine synthase (sprot)

A spermidine synthase that is encoded in the genome of human.


spermidine synthase activity

description: Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine.


spermidine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.


name: SL9A1_HUMAN Sodium/hydrogen exchanger 1 (sprot)

description: A sodium/hydrogen exchanger 1 that is encoded in the genome of human.


name: sodium:proton antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).


name: sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential

description: Enables the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential.


cellular response to antibiotic

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.


name: regulation of the force of heart contraction by cardiac conduction

description: A cardiac conduction process that modulates the extent of heart contraction, changing the force with which blood is propelled.


cation-transporting ATPase complex

description: Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).


name: A1AG2_HUMAN Alpha-1-acid glycoprotein 2 (sprot)

description: An alpha-1-acid glycoprotein 2 that is encoded in the genome of human.


name: CSK22_HUMAN Casein kinase II subunit alpha' (sprot)

description: A casein kinase II subunit alpha' that is encoded in the genome of human.


regulation of chromosome separation

description: Any process that modulates the frequency, rate or extent of chromosome separation.


protein kinase CK2 complex

description: A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein.


name: RXRA_HUMAN Retinoic acid receptor RXR-alpha (sprot)

description: A retinoic acid receptor RXR-alpha that is encoded in the genome of human.


DNA binding domain binding

description: Binding to a protein's DNA binding domain (DBD).


LBD domain binding

description: Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket.


name: AOC1_HUMAN Diamine oxidase [copper-containing] (sprot)

description: An amiloride-sensitive amine oxidase [copper-containing] that is encoded in the genome of human.


putrescine oxidase activity

description: Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2.


diamine oxidase activity

description: Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide.


histamine oxidase activity

description: Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+.


methylputrescine oxidase activity

description: Catalysis of the reaction: N-methylputrescine + H2O + O2 = N-methylaminobutanal + NH3 + hydrogen peroxide + H+.


propane-1,3-diamine oxidase activity

description: Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+.


putrescine metabolic process

description: The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine.


name: ITIH2_HUMAN Inter-alpha-trypsin inhibitor heavy chain H2 (sprot)

description: An inter-alpha-trypsin inhibitor heavy chain H2 that is encoded in the genome of human.


hyaluronan metabolic process

description: The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.


name: ITIH1_HUMAN Inter-alpha-trypsin inhibitor heavy chain H1 (sprot)

description: An inter-alpha-trypsin inhibitor heavy chain H1 that is encoded in the genome of human.


name: CEL_HUMAN Bile salt-activated lipase (sprot)

description: A bile salt-activated lipase that is encoded in the genome of human.


name: NFKB1_HUMAN Nuclear factor NF-kappa-B p105 subunit (sprot)

description: A nuclear factor NF-kappa-B p105 subunit that is encoded in the genome of human.


I-kappaB/NF-kappaB complex

description: A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm.


name: CXCL2_HUMAN C-X-C motif chemokine 2 (sprot)

description: A C-X-C motif chemokine 2 that is encoded in the genome of human.


name: CXCL3_HUMAN C-X-C motif chemokine 3 (sprot)

description: A C-X-C motif chemokine 3 that is encoded in the genome of human.


name: NCF2_HUMAN Neutrophil cytosol factor 2 (sprot)

description: A neutrophil cytosol factor 2 that is encoded in the genome of human.


FST_HUMAN Follistatin (sprot)

A follistatin that is encoded in the genome of human.


activin receptor antagonist activity

description: Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor.


ELAF_HUMAN Elafin (sprot)

An elafin that is encoded in the genome of human.


copulation

description: The act of sexual union between male and female, involving the transfer of sperm.


AMY2B_HUMAN Alpha-amylase 2B (sprot)

An alpha-amylase 2B that is encoded in the genome of human.


name: TYPH_HUMAN Thymidine phosphorylase (sprot)

description: A thymidine phosphorylase that is encoded in the genome of human.


description: Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase.


thymidine phosphorylase activity

description: Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate.


pyrimidine nucleobase metabolic process

description: The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.


pyrimidine nucleoside metabolic process

description: The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).


dTMP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate.


name: regulation of transmission of nerve impulse

description: Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.


regulation of gastric motility

description: Any process that modulates the frequency, rate or extent of gastric motility.


name: AT2B1_HUMAN Plasma membrane calcium-transporting ATPase 1 (sprot)

description: A plasma membrane calcium-transporting ATPase 1 that is encoded in the genome of human.


name: calcium ion transmembrane transporter activity

description: Enables the transfer of calcium (Ca) ions from one side of a membrane to the other.


name: calcium ion export across plasma membrane

description: The directed movement of calcium ions from inside of a cell, across the plasma membrane and into the extracellular region.


name: CR2_HUMAN Complement receptor type 2 (sprot)

description: A complement receptor type 2 that is encoded in the genome of human.


complement receptor activity

description: Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: DPA1_HUMAN HLA class II histocompatibility antigen, DP alpha 1 chain (sprot)

description: An MHC class II histocompatibility antigen alpha chain DPA1 that is encoded in the genome of human.


name: IF2B_HUMAN Eukaryotic translation initiation factor 2 subunit 2 (sprot)

description: A eukaryotic translation initiation factor 2 subunit 2 that is encoded in the genome of human.


cytoplasmic translational initiation

description: The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.


TCO1_HUMAN Transcobalamin-1 (sprot)

A transcobalamin-1 that is encoded in the genome of human.


cargo receptor ligand activity

description: The activity of a gene product that interacts with a cargo receptor and initiates endocytosis.


cobalt ion transport

description: The directed movement of cobalt (Co2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


TCO2_HUMAN Transcobalamin-2 (sprot)

A transcobalamin-2 that is encoded in the genome of human.


ANXA7_HUMAN Annexin A7 (sprot)

An annexin A7 that is encoded in the genome of human.


name: SDHL_HUMAN L-serine dehydratase/L-threonine deaminase (sprot)

description: An L-serine dehydratase/L-threonine deaminase that is encoded in the genome of human.


L-serine ammonia-lyase activity

description: Catalysis of the reaction: L-serine = pyruvate + NH3.


L-serine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.


pyruvate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate.


name: CD33_HUMAN Myeloid cell surface antigen CD33 (sprot)

description: A CD33 molecule that is encoded in the genome of human.


name: immune response-inhibiting signal transduction

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response.


PEPC_HUMAN Gastricsin (sprot)

A gastricsin that is encoded in the genome of human.


KLK2_HUMAN Kallikrein-2 (sprot)

A kallikrein-2 that is encoded in the genome of human.


name: ISK2_HUMAN Serine protease inhibitor Kazal-type 2 (sprot)

description: A serine protease inhibitor Kazal-type 2 that is encoded in the genome of human.


acrosome assembly

description: The formation of the acrosome from the spermatid Golgi.


CAP7_HUMAN Azurocidin (sprot)

An azurocidin that is encoded in the genome of human.


cellular extravasation

description: The migration of a leukocyte from the blood vessels into the surrounding tissue.


name: neutrophil-mediated killing of bacterium

description: The directed killing of a bacterium by a neutrophil.


name: TBP_HUMAN TATA-box-binding protein (sprot)

description: A TATA-box-binding protein that is encoded in the genome of human.


name: RNA polymerase transcription factor SL1 complex

description: A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.


transcription factor TFIIA complex

description: A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).


TRYB2_HUMAN Tryptase beta-2 (sprot)

A tryptase beta-2 that is encoded in the genome of human.


CCNA2_HUMAN Cyclin-A2 (sprot)

A cyclin-A2 that is encoded in the genome of human.


cell cycle G1/S phase transition

description: The cell cycle process by which a cell in G1 phase commits to S phase.


cyclin A2-CDK2 complex

description: A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


name: PO3F3_HUMAN POU domain, class 3, transcription factor 3 (sprot)

description: A POU domain, class 3, transcription factor 3 that is encoded in the genome of human.


name: forebrain ventricular zone progenitor cell division

description: The mitotic division of a basal progenitor giving rise to two neurons.


chemical homeostasis

description: Any biological process involved in the maintenance of an internal steady state of a chemical.


metanephric macula densa development

description: The process whose specific outcome is the progression of the metanephric macula densa over time, from its formation to the mature structure. The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus.


metanephric loop of Henle development

description: The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros.


metanephric DCT cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the metanephros as it progresses from its formation to the mature state.


name: PO3F2_HUMAN POU domain, class 3, transcription factor 2 (sprot)

description: A POU domain, class 3, transcription factor 2 that is encoded in the genome of human.


neurohypophysis development

description: The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation.


CD22_HUMAN B-cell receptor CD22 (sprot)

A B-cell receptor CD22 that is encoded in the genome of human.


regulation of B cell proliferation

description: Any process that modulates the frequency, rate or extent of B cell proliferation.


name: BTF3_HUMAN Transcription factor BTF3 (sprot)

description: A transcription factor BTF3 that is encoded in the genome of human.


name: negative regulation of protein localization to endoplasmic reticulum

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endoplasmic reticulum.


name: AL5AP_HUMAN Arachidonate 5-lipoxygenase-activating protein (sprot)

description: An arachidonate 5-lipoxygenase-activating protein that is encoded in the genome of human.


name: ACM3_HUMAN Muscarinic acetylcholine receptor M3 (sprot)

description: A muscarinic acetylcholine receptor M3 that is encoded in the genome of human.


name: TNR1B_HUMAN Tumor necrosis factor receptor superfamily member 1B (sprot)

description: A tumor necrosis factor receptor superfamily member 1B that is encoded in the genome of human.


name: regulation of cytokine production involved in immune response

description: Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response.


name: regulation of T cell cytokine production

description: Any process that modulates the frequency, rate, or extent of T cell cytokine production.


glial cell-neuron signaling

description: Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum.


name: RAB3A_HUMAN Ras-related protein Rab-3A (sprot)

description: A Ras-related protein Rab-3A that is encoded in the genome of human.


constitutive secretory pathway

description: A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space.


name: maintenance of presynaptic active zone structure

description: A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters.


sensory perception of touch

description: The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).


evoked neurotransmitter secretion

description: Neurotransmitter secretion that occurs in the presence of the action of a secretagogue or a presynaptic action potential.


name: regulation of presynaptic dense core granule exocytosis

description: Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis.


regulation of plasma membrane repair

description: Any process that modulates the frequency, rate or extent of plasma membrane repair.


name: clathrin-sculpted acetylcholine transport vesicle membrane

description: The lipid bilayer surrounding a clathrin-sculpted acetylcholine transport vesicle.


name: clathrin-sculpted glutamate transport vesicle membrane

description: The lipid bilayer surrounding a clathrin-sculpted glutamate transport vesicle.


name: clathrin-sculpted monoamine transport vesicle membrane

description: The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle.


name: RAB3B_HUMAN Ras-related protein Rab-3B (sprot)

description: A Ras-related protein Rab-3B that is encoded in the genome of human.


regulation of vesicle size

description: Any process that modulates the size of a vesicle.


name: RAB4A_HUMAN Ras-related protein Rab-4A (sprot)

description: A Ras-related protein Rab-4A that is encoded in the genome of human.


Rab protein signal transduction

description: An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal.


name: RAB5A_HUMAN Ras-related protein Rab-5A (sprot)

description: A Ras-related protein Rab-5A that is encoded in the genome of human.


amyloid-beta clearance by transcytosis

description: The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier.


name: cytoplasmic side of early endosome membrane

description: The side (leaflet) of the early endosome membrane that faces the cytoplasm.


name: RAB6A_HUMAN Ras-related protein Rab-6A (sprot)

description: A Ras-related protein Rab-6A that is encoded in the genome of human.


peptidyl-cysteine methylation

description: The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine.


name: minus-end-directed organelle transport along microtubule

description: The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.


protein localization to Golgi membrane

description: A process in which a protein is transported to, or maintained in, a location within a Golgi membrane.


name: endosome to plasma membrane transport vesicle

description: A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane and to release various cargo molecules, such as proteins or hormones, by exocytosis.


TKN1_HUMAN Protachykinin-1 (sprot)

A protachykinin-1 that is encoded in the genome of human.


detection of abiotic stimulus

description: The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal.


MCH_HUMAN Pro-MCH (sprot)

A pro-MCH that is encoded in the genome of human.


melanin-concentrating hormone activity

description: The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals.


name: NR1D1_HUMAN Nuclear receptor subfamily 1 group D member 1 (sprot)

description: A nuclear receptor subfamily 1 group D member 1 that is encoded in the genome of human.


name: regulation of circadian sleep/wake cycle

description: Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle.


name: positive regulation of bile acid biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.


name: TRH_HUMAN Pro-thyrotropin-releasing hormone (sprot)

description: A pro-thyrotropin-releasing hormone that is encoded in the genome of human.


PRVA_HUMAN Parvalbumin alpha (sprot)

A parvalbumin alpha that is encoded in the genome of human.


name: MSH3_HUMAN DNA mismatch repair protein Msh3 (sprot)

description: A DNA mismatch repair protein Msh3 that is encoded in the genome of human.


guanine/thymine mispair binding

description: Binding to a double-stranded DNA region containing a G/T mispair.


single guanine insertion binding

description: Binding to a double-stranded DNA region containing a single guanine insertion or a deletion that results in an unpaired guanine.


dinucleotide repeat insertion binding

description: Binding to a double-stranded DNA region containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats.


maintenance of DNA repeat elements

description: Any process involved in sustaining the fidelity and copy number of DNA repeat elements.


name: negative regulation of DNA recombination

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.


name: positive regulation of helicase activity

description: Any process that activates or increases the activity of a helicase.


MutSbeta complex

description: A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3.


name: MX1_HUMAN Interferon-induced GTP-binding protein Mx1 (sprot)

description: An interferon-induced GTP-binding protein Mx1 that is encoded in the genome of human.


name: MX2_HUMAN Interferon-induced GTP-binding protein Mx2 (sprot)

description: An interferon-induced GTP-binding protein Mx2 that is encoded in the genome of human.


name: ANPRB_HUMAN Atrial natriuretic peptide receptor 2 (sprot)

description: An atrial natriuretic peptide receptor 2 that is encoded in the genome of human.


cumulus cell differentiation

description: The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell.


vestibulocochlear nerve maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.


response to luteinizing hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus.


genitalia morphogenesis

description: The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal.


gastric emptying

description: The process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum.


name: negative regulation of meiotic cell cycle

description: Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.


name: activation of meiosis involved in egg activation

description: Any process that starts the inactive process of meiosis in an egg after the egg has been fertilized or physiologically activated. Eggs generally arrest in meiosis and complete the process after activation.


c-di-GMP signaling

description: Any process that mediates the transfer of information from one cell to another using c-di-GMP as the signal.


name: PSB1_HUMAN Proteasome subunit beta type-1 (sprot)

description: A proteasome subunit beta type-1 that is encoded in the genome of human.


name: MPRD_HUMAN Cation-dependent mannose-6-phosphate receptor (sprot)

description: A cation-dependent mannose-6-phosphate receptor that is encoded in the genome of human.


secretion of lysosomal enzymes

description: The controlled release of lysosomal enzymes by a cell.


name: ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1 (sprot)

description: A potassium-transporting ATPase alpha chain 1 that is encoded in the genome of human.


name: P-type potassium:proton transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in).


regulation of proton transport

description: Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: potassium:proton exchanging ATPase complex

description: A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present.


name: H2A1D_HUMAN Histone H2A type 1-D (sprot)

description: A histone H2A type 1-D that is encoded in the genome of human.


name: COX5A_HUMAN Cytochrome c oxidase subunit 5A, mitochondrial (sprot)

description: A cytochrome c oxidase subunit 5A, mitochondrial that is encoded in the genome of human.


LMNB1_HUMAN Lamin-B1 (sprot)

A lamin-B1 that is encoded in the genome of human.


ITAL_HUMAN Integrin alpha-L (sprot)

An integrin alpha-L that is encoded in the genome of human.


memory T cell extravasation

description: The migration of a memory T cell from the blood vessels into the surrounding tissue. A memory T cell is a distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive.


ITAX_HUMAN Integrin alpha-X (sprot)

An integrin alpha-X that is encoded in the genome of human.


name: positive regulation of endothelial tube morphogenesis

description: Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis.


name: DDC_HUMAN Aromatic-L-amino-acid decarboxylase (sprot)

description: An aromatic-L-amino-acid decarboxylase that is encoded in the genome of human.


description: Catalysis of the reaction: L-amino acid + H+ = R-H + CO2.


description: Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin.


L-dopa decarboxylase activity

description: Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine.


GRAH_HUMAN Granzyme H (sprot)

A granzyme H that is encoded in the genome of human.


name: HXA5_HUMAN Homeobox protein Hox-A5 (sprot)

description: A homeobox protein Hox-A5 that is encoded in the genome of human.


name: negative regulation of erythrocyte differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.


trachea cartilage morphogenesis

description: The process in which the anatomical structures of cartilage in the trachea are generated and organized.


mesenchymal-epithelial cell signaling

description: Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted.


name: PZP_HUMAN Pregnancy zone protein (sprot)

description: A pregnancy zone protein that is encoded in the genome of human.


name: BCL3_HUMAN B-cell lymphoma 3 protein (sprot)

description: A B-cell lymphoma 3 protein that is encoded in the genome of human.


name: follicular dendritic cell differentiation

description: The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell.


regulation of DNA binding

description: Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).


Bcl3-Bcl10 complex

description: A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus.


Bcl3/NF-kappaB2 complex

description: A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription.


MIME_HUMAN Mimecan (sprot)

A mimecan that is encoded in the genome of human.


NTF3_HUMAN Neurotrophin-3 (sprot)

A neurotrophin-3 that is encoded in the genome of human.


name: MAK_HUMAN Serine/threonine-protein kinase MAK (sprot)

description: A serine/threonine-protein kinase MAK that is encoded in the genome of human.


name: negative regulation of non-motile cilium assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of non-motile cilium assembly.


EDN2_HUMAN Endothelin-2 (sprot)

An endothelin-2 that is encoded in the genome of human.


name: hormonal regulation of the force of heart contraction

description: The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.


name: positive regulation of the force of heart contraction by chemical signal

description: Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.


cell tip growth

description: Growth that occurs specifically at the tip of a cell.


CAN3_HUMAN Calpain-3 (sprot)

A calpain-3 that is encoded in the genome of human.


ligase regulator activity

description: Binds to and modulates the activity of a ligase.


name: negative regulation of protein sumoylation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.


name: G1 to G0 transition involved in cell differentiation

description: A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters G0 phase, in the context of cell differentiation.


cellular response to salt stress

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.


calcium-dependent self proteolysis

description: The calcium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.


IL11_HUMAN Interleukin-11 (sprot)

An interleukin-11 that is encoded in the genome of human.


interleukin-11 receptor binding

description: Binding to an interleukin-11 receptor.


ICAL_HUMAN Calpastatin (sprot)

A calpastatin that is encoded in the genome of human.


name: calcium-dependent cysteine-type endopeptidase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner.


name: inhibition of cysteine-type endopeptidase activity

description: Any process that prevents the activation of an inactive cysteine-type endopeptidase.


presynaptic active zone organization

description: A process that results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic active zone.


CP2B6_HUMAN Cytochrome P450 2B6 (sprot)

A cytochrome P450 2B6 that is encoded in the genome of human.


description: Catalysis of the reaction: testosterone + donor-H2 + O2 = 16-alpha-hydroxytestosterone + H2O.


description: Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


cellular ketone metabolic process

description: The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.


CP3A5_HUMAN Cytochrome P450 3A5 (sprot)

A cytochrome P450 3A5 that is encoded in the genome of human.


name: HNF1A_HUMAN Hepatocyte nuclear factor 1-alpha (sprot)

description: A hepatocyte nuclear factor 1-alpha that is encoded in the genome of human.


regulation of pronephros size

description: Any process that modulates the size of a pronephric kidney.


EFNA1_HUMAN Ephrin-A1 (sprot)

An ephrin-A1 that is encoded in the genome of human.


name: endocardial cushion to mesenchymal transition involved in heart valve formation

description: A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.


notochord formation

description: The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.


name: regulation of blood vessel endothelial cell migration

description: Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.


name: negative regulation of dendritic spine morphogenesis

description: Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.


name: negative regulation of proteolysis involved in protein catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process.


name: IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (sprot)

description: An inosine-5'-monophosphate dehydrogenase 1 that is encoded in the genome of human.


name: A1ATR_HUMAN Alpha-1-antitrypsin-related protein (sprot)

description: A protein that is a translation product of the SERPINA2 gene in human.


name: CO9A1_HUMAN Collagen alpha-1(IX) chain (sprot)

description: A collagen alpha-1(IX) chain that is encoded in the genome of human.


collagen type IX trimer

description: A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils.


name: C4BPB_HUMAN C4b-binding protein beta chain (sprot)

description: A C4b-binding protein beta chain that is encoded in the genome of human.


CP2A7_HUMAN Cytochrome P450 2A7 (sprot)

A cytochrome P450 2A that is a translation product of the CYP2A7 gene in human.


name: CO5A1_HUMAN Collagen alpha-1(V) chain (sprot)

description: A collagen alpha-1(V) chain that is encoded in the genome of human.


integrin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules.


name: regulation of cellular component organization

description: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.


name: MAG_HUMAN Myelin-associated glycoprotein (sprot)

description: A myelin-associated glycoprotein that is encoded in the genome of human.


compact myelin

description: The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs.


mesaxon

description: Portion of the ensheathing process (either myelin or non-myelin) where the enveloping lips of the ensheathing cell come together so that their apposed plasma membranes run parallel to each other, separated by a cleft 12 nm wide.


NEBU_HUMAN Nebulin (sprot)

A nebulin that is encoded in the genome of human.


somatic muscle development

description: The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.


regulation of actin filament length

description: Any process that controls the length of actin filaments in a cell.


FILA_HUMAN Filaggrin (sprot)

A filaggrin that is encoded in the genome of human.


An N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase that is encoded in the genome of human.


description: Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H+.


name: RASA1_HUMAN Ras GTPase-activating protein 1 (sprot)

description: A Ras GTPase-activating protein 1 that is encoded in the genome of human.


regulation of RNA metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.


PHOS_HUMAN Phosducin (sprot)

A phosducin that is encoded in the genome of human.


PTMS_HUMAN Parathymosin (sprot)

A parathymosin that is encoded in the genome of human.


name: CD3Z_HUMAN T-cell surface glycoprotein CD3 zeta chain (sprot)

description: A T-cell surface glycoprotein CD3 that is encoded in the genome of human.


name: PRPS3_HUMAN Ribose-phosphate pyrophosphokinase 3 (sprot)

description: A ribose-phosphate pyrophosphokinase 3 that is encoded in the genome of human.


name: CD11B_HUMAN Cyclin-dependent kinase 11B (sprot)

description: A cyclin-dependent kinase 11B that is encoded in the genome of human.


regulation of mRNA processing

description: Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.


name: ENDOU_HUMAN Uridylate-specific endoribonuclease (sprot)

description: A uridylate-specific endoribonuclease that is encoded in the genome of human.


post-transcriptional gene silencing

description: The inactivation of gene expression that occurs after transcription.


name: MAL_HUMAN Myelin and lymphocyte protein (sprot)

description: A myelin and lymphocyte protein that is encoded in the genome of human.


structural constituent of myelin sheath

description: The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve.


name: protein localization to paranode region of axon

description: A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon.


protein insertion into plasma membrane

description: The process that results in the incorporation of a protein into a plasma membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.


name: hinge region between urothelial plaques of apical plasma membrane

description: A narrow rim of non-thickened membrane in between urothelial plaques in apical plasma membrane.


name: FUT3_HUMAN 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (sprot)

description: A 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 that is encoded in the genome of human.


description: Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R.


description: Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R.


description: Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage.


cell-cell recognition

description: Cell recognition between cells. May involve the formation of specialized cell junctions.


macromolecule glycosylation

description: The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.


PTN_HUMAN Pleiotrophin (sprot)

A pleiotrophin that is encoded in the genome of human.


name: ossification involved in bone remodeling

description: The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli.


dendrite arborization

description: The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches.


name: GSTM3_HUMAN Glutathione S-transferase Mu 3 (sprot)

description: A glutathione S-transferase mu 3 that is encoded in the genome of human.


name: VATB2_HUMAN V-type proton ATPase subunit B, brain isoform (sprot)

description: A V-type proton ATPase subunit B, brain isoform that is encoded in the genome of human.


name: VATC1_HUMAN V-type proton ATPase subunit C 1 (sprot)

description: A V-type proton ATPase subunit C 1 that is encoded in the genome of human.


name: proton-transporting two-sector ATPase complex

description: A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.


name: CSRP1_HUMAN Cysteine and glycine-rich protein 1 (sprot)

description: A cysteine and glycine-rich protein 1 that is encoded in the genome of human.


FLNA_HUMAN Filamin-A (sprot)

A filamin-A that is encoded in the genome of human.


tubulin deacetylation

description: The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


establishment of Sertoli cell barrier

description: Establishment of a structure near the basement membrane in adjacent Sertoli cells of the seminiferous epithelium for maintaining spermatogenesis. The structure consists of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions.


name: protein localization to bicellular tight junction

description: A process in which a protein is transported to, or maintained in, a location within a bicellular tight junction.


name: regulation of membrane repolarization during atrial cardiac muscle cell action potential

description: Any process that modulates the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential.


name: regulation of membrane repolarization during cardiac muscle cell action potential

description: Any process that modulates the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential.


NF1_HUMAN Neurofibromin (sprot)

A neurofibromin that is encoded in the genome of human.


mast cell apoptotic process

description: Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.


name: positive regulation of mast cell apoptotic process

description: Any process that activates or increases the frequency, rate, or extent of mast cell apoptotic process.


name: negative regulation of Rac protein signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction.


name: regulation of glial cell differentiation

description: Any process that modulates the frequency, rate or extent of glia cell differentiation.


name: positive regulation of adenylate cyclase activity

description: Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.


name: negative regulation of neurotransmitter secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter.


name: negative regulation of oligodendrocyte differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.


glutamate secretion, neurotransmission

description: The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter.


observational learning

description: Learning that occurs through observing the behavior of others.


name: regulation of long-term synaptic potentiation

description: Any process that modulates the frequency, rate or extent of long-term synaptic potentiation.


name: vascular associated smooth muscle cell migration

description: The orderly movement of a vascular associated smooth muscle cell from one site to another.


name: vascular associated smooth muscle cell proliferation

description: The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.


name: AOFA_HUMAN Amine oxidase [flavin-containing] A (sprot)

description: An amine oxidase [flavin-containing] A that is encoded in the genome of human.


monoamine oxidase activity

description: Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.


name: ACOHC_HUMAN Cytoplasmic aconitate hydratase (sprot)

description: A cytoplasmic aconitate hydratase that is encoded in the genome of human.


aconitate hydratase activity

description: Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.


iron-responsive element binding

description: Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins.


3 iron, 4 sulfur cluster binding

description: Binding to a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing.


response to iron(II) ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus.


name: MDR3_HUMAN Phosphatidylcholine translocator ABCB4 (sprot)

description: A phosphatidylcholine translocator ABCB4 that is encoded in the genome of human.


name: positive regulation of phospholipid translocation

description: Any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.


response to fenofibrate

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fenofibrate stimulus.


cellular response to bile acid

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.


NK2R_HUMAN Substance-K receptor (sprot)

A substance-K receptor that is encoded in the genome of human.


tachykinin receptor activity

description: Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein.


tachykinin receptor signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. Tachykinin is a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2).


name: positive regulation of acetylcholine secretion, neurotransmission

description: Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine.


intestine smooth muscle contraction

description: A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine.


name: S1PR1_HUMAN Sphingosine 1-phosphate receptor 1 (sprot)

description: A sphingosine 1-phosphate receptor 1 that is encoded in the genome of human.


sphingolipid binding

description: Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


name: cardiac muscle tissue growth involved in heart morphogenesis

description: The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart.


name: FPR1_HUMAN fMet-Leu-Phe receptor (sprot)

description: An fMet-Leu-Phe receptor that is encoded in the genome of human.


N-formyl peptide receptor activity

description: Combining with an N-formyl peptide to initiate a change in cell activity.


name: ZNF10_HUMAN Zinc finger protein 10 (sprot)

description: A zinc finger protein 10 that is encoded in the genome of human.


name: AGT1_HUMAN Alanine--glyoxylate aminotransferase (sprot)

description: An alanine--glyoxylate aminotransferase that is encoded in the genome of human.


serine-pyruvate transaminase activity

description: Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.


description: Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.


transaminase activity

description: Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.


L-serine metabolic process

description: The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.


glyoxylate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH.


name: glycine biosynthetic process, by transamination of glyoxylate

description: The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate.


L-cysteine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid.


L-alanine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.


glyoxylate metabolic process

description: The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.


oxalic acid secretion

description: The controlled release of oxalic acid, ethanedioic acid, by a cell or a tissue.


name: CNR1_HUMAN Cannabinoid receptor 1 (sprot)

description: A cannabinoid receptor 1 that is encoded in the genome of human.


cannabinoid receptor activity

description: Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids.


name: positive regulation of acute inflammatory response to antigenic stimulus

description: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.


name: negative regulation of serotonin secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.


name: negative regulation of mast cell activation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation.


cannabinoid signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by a cannabinoid binding to its receptor on the cell surface, and ending with the regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids.


regulation of penile erection

description: Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow.


name: retrograde trans-synaptic signaling by endocannabinoid

description: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand.


name: trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

description: Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse.


SYT1_HUMAN Synaptotagmin-1 (sprot)

A synaptotagmin-1 that is encoded in the genome of human.


syntaxin-3 binding

description: Binding to a syntaxin-3 SNAP receptor.


vesicle docking

description: The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere.


spontaneous neurotransmitter secretion

description: Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential.


synchronous neurotransmitter secretion

description: Release of neurotransmitter at the synapse that lasts for just a few milliseconds after action potential invasion.


name: fast, calcium ion-dependent exocytosis of neurotransmitter

description: The fast, initial phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on low affinity calcium sensors and typically begins a fraction of a millisecond after Ca2+ influx, and decays rapidly (1-10ms) with a decay constant of around 5-10ms. The underlying molecular mechanisms of this process are distinct from those of the later, slow phase of release.


name: calcium-dependent activation of synaptic vesicle fusion

description: The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane.


name: positive regulation of calcium ion-dependent exocytosis of neurotransmitter

description: Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter.


name: regulation of regulated secretory pathway

description: Any process that modulates the frequency, rate or extent of regulated secretory pathway.


name: TNAP3_HUMAN Tumor necrosis factor alpha-induced protein 3 (sprot)

description: A tumor necrosis factor alpha-induced protein 3 that is encoded in the genome of human.


regulation of germinal center formation

description: Any process that modulates the frequency, rate, or extent of germinal center formation.


response to muramyl dipeptide

description: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.


name: negative regulation of toll-like receptor 3 signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 3 signaling pathway.


name: negative regulation of toll-like receptor 5 signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 5 signaling pathway.


protein K11-linked deubiquitination

description: A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein.


name: negative regulation of B cell activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation.


regulation of vascular wound healing

description: Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.


name: negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway.


name: negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.


name: establishment of protein localization to vacuole

description: The directed movement of a protein to a specific location in a vacuole.


name: negative regulation of CD40 signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the CD40 signaling pathway.


SCF_HUMAN Kit ligand (sprot)

A kit ligand that is encoded in the genome of human.


name: positive regulation of myeloid leukocyte differentiation

description: Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.


name: negative regulation of mast cell apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process.


mast cell migration

description: The movement of a mast cell within or between different tissues and organs of the body.


name: positive regulation of hematopoietic progenitor cell differentiation

description: Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.


5NTD_HUMAN 5'-nucleotidase (sprot)

A 5'-nucleotidase that is encoded in the genome of human.


5'-deoxynucleotidase activity

description: Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate.


thymidylate 5'-phosphatase activity

description: Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate.


IMP 5'-nucleotidase activity

description: Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate.


GMP 5'-nucleotidase activity

description: Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate.


ADP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate.


adenosine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.


name: SAT1_HUMAN Diamine acetyltransferase 1 (sprot)

description: A diamine acetyltransferase 1 that is encoded in the genome of human.


diamine N-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.


N-acetyltransferase activity

description: Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.


putrescine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine.


spermidine acetylation

description: The modification of spermidine by addition of acetyl groups.


name: TAF1_HUMAN Transcription initiation factor TFIID subunit 1 (sprot)

description: A transcription initiation factor TFIID subunit 1 that is encoded in the genome of human.


acetyl-CoA binding

description: Binding to acetyl-CoA, an acyl-CoA having acetyl as its S-acetyl component.


H3K27me3 modified histone binding

description: Binding to a histone H3 in which the lysine residue at position 27 has been modified by trimethylation.


name: regulation of cell cycle G1/S phase transition

description: Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.


name: negative regulation of protein autoubiquitination

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein autoubiquitination.


name: positive regulation of androgen receptor activity

description: Any process that activates or increases the frequency, rate or extent of androgen receptor activity.


name: GPDA_HUMAN Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (sprot)

description: A glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic that is encoded in the genome of human.


name: glycerol-3-phosphate dehydrogenase (quinone) activity

description: Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.


name: glycerol-3-phosphate dehydrogenase (NAD+) activity

description: Catalysis of the reaction: NAD+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADH.


glycerophosphate shuttle

description: The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle.


glycerol-3-phosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol.


glycerolipid metabolic process

description: The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.


name: EPHA1_HUMAN Ephrin type-A receptor 1 (sprot)

description: An ephrin type-A receptor 1 that is encoded in the genome of human.


transmembrane-ephrin receptor activity

description: Combining with a transmembrane ephrin to initiate a change in cell activity.


name: DRD1_HUMAN D(1A) dopamine receptor (sprot)

description: A D(1A) dopamine receptor that is encoded in the genome of human.


name: dopamine neurotransmitter receptor activity, coupled via Gs

description: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity.


name: dopamine neurotransmitter receptor activity

description: Combining with the neurotransmitter dopamine to initiate a change in cell activity.


sensitization

description: An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched.


name: C5AR1_HUMAN C5a anaphylatoxin chemotactic receptor 1 (sprot)

description: A C5a anaphylatoxin chemotactic receptor 1 that is encoded in the genome of human.


name: complement component C5a receptor activity

description: Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: complement component C5a signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by a C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor.


name: regulation of tau-protein kinase activity

description: Any process that modulates the frequency, rate or extent of tau-protein kinase activity.


name: TA2R_HUMAN Thromboxane A2 receptor (sprot)

description: A thromboxane A2 receptor that is encoded in the genome of human.


thromboxane A2 receptor activity

description: Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein.


thromboxane A2 signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by thromboxane A2 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


MK_HUMAN Midkine (sprot)

A midkine that is encoded in the genome of human.


cerebellar granular layer development

description: The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.


defecation

description: The expulsion of feces from the rectum.


name: positive regulation of smooth muscle cell chemotaxis

description: Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis.


name: positive regulation of inflammatory response to wounding

description: Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding.


name: ZP3_HUMAN Zona pellucida sperm-binding protein 3 (sprot)

description: A zona pellucida sperm-binding protein 3 that is encoded in the genome of human.


structural constituent of egg coat

description: The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.


name: positive regulation of type IV hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response.


name: positive regulation of humoral immune response

description: Any process that activates or increases the frequency, rate, or extent of a humoral immune response.


egg coat formation

description: Construction of an egg coat, a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.


name: negative regulation of binding of sperm to zona pellucida

description: Any process that stops, prevents or reduces the frequency, rate or extent of binding of sperm to the zona pellucida.


name: positive regulation of antral ovarian follicle growth

description: Any process that activates or increases the frequency, rate or extent of antral ovarian follicle growth.


egg coat

description: A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.


name: MSRE_HUMAN Macrophage scavenger receptor types I and II (sprot)

description: A macrophage scavenger receptor types I and II that is encoded in the genome of human.


name: FGF7_HUMAN Fibroblast growth factor 7 (sprot)

description: A fibroblast growth factor 7 that is encoded in the genome of human.


name: VDAC1_HUMAN Voltage-dependent anion-selective channel protein 1 (sprot)

description: A voltage-dependent anion-selective channel protein 1 that is encoded in the genome of human.


ceramide binding

description: Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes.


calcium import into the mitochondrion

description: A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix.


name: negative regulation of calcium import into the mitochondrion

description: Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into the mitochondrion.


name: positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

description: Any process that activates or increases the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization.


name: FGFR2_HUMAN Fibroblast growth factor receptor 2 (sprot)

description: A fibroblast growth factor receptor 2 that is encoded in the genome of human.


endochondral bone growth

description: The increase in size or mass of an endochondral bone that contributes to the shaping of the bone.


name: fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell

description: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow.


name: fibroblast growth factor receptor signaling pathway involved in hemopoiesis

description: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which contributes to hemopoiesis.


name: fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow

description: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which activates or increases the frequency, rate or extent of cell proliferation in the bone marrow.


prostate gland morphogenesis

description: The process in which the anatomical structures of a prostate gland are generated and organized.


name: squamous basal epithelial stem cell differentiation involved in prostate gland acinus development

description: The process in which a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate.


lateral sprouting from an epithelium

description: The process in which a branch forms along the side of an epithelium.


name: regulation of morphogenesis of a branching structure

description: Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized.


PGS1_HUMAN Biglycan (sprot)

A biglycan that is encoded in the genome of human.


articular cartilage development

description: The process whose specific outcome is the progression of articular cartilage over time, from its formation to the mature structure.


name: SIAL_HUMAN Integrin-binding sialoprotein (sprot)

description: A bone sialoprotein 2 that is encoded in the genome of human.


RYR1_HUMAN Ryanodine receptor 1 (sprot)

A ryanodine receptor 1 that is encoded in the genome of human.


name: ryanodine-sensitive calcium-release channel activity

description: Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration and is sensitive to the plant alkaloid ryanodine.


name: calcium-induced calcium release activity

description: Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration.


response to caffeine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.


ryanodine receptor complex

description: A voltage-gated calcium-release channel complex of the sarcoplasmic or endoplasmic reticulum. It plays an important role in the excitation-contraction (E-C) coupling of muscle cells. RyR comprises a family of ryanodine receptors, widely expressed throughout the animal kingdom.


name: CD72_HUMAN B-cell differentiation antigen CD72 (sprot)

description: A CD72 molecule that is encoded in the genome of human.


name: ERBB3_HUMAN Receptor tyrosine-protein kinase erbB-3 (sprot)

description: A receptor tyrosine-protein kinase erbB-3 that is encoded in the genome of human.


cranial nerve development

description: The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.


name: SDHB_HUMAN Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sprot)

description: A succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial that is encoded in the genome of human.


name: DRD4_HUMAN D(4) dopamine receptor (sprot)

description: A D(4) dopamine receptor that is encoded in the genome of human.


inhibitory postsynaptic potential

description: A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.


name: DRD5_HUMAN D(1B) dopamine receptor (sprot)

description: A D(1B) dopamine receptor that is encoded in the genome of human.


name: regulation of systemic arterial blood pressure by vasopressin

description: The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport.


name: norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

description: A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure.


regulation of female receptivity

description: Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances.


CD9_HUMAN CD9 antigen (sprot)

A CD9 molecule that is encoded in the genome of human.


name: MATN1_HUMAN Cartilage matrix protein (sprot)

description: A cartilage matrix protein that is encoded in the genome of human.


name: growth plate cartilage chondrocyte morphogenesis

description: The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized.


name: ODBB_HUMAN 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (sprot)

description: A 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial that is encoded in the genome of human.


name: COMT_HUMAN Catechol O-methyltransferase (sprot)

description: A catechol O-methyltransferase that is encoded in the genome of human.


catechol O-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.


renin secretion into blood stream

description: The regulated release of renin into the blood stream by juxtoglomerular cells.


name: cellular response to phosphate starvation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.


catecholamine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.


norepinephrine secretion

description: The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system.


mastication

description: The process of biting and mashing food with the teeth prior to swallowing.


renal filtration

description: A renal system process in which fluid circulating through the body is filtered through a barrier system.


response to dopamine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus.


name: TGM2_HUMAN Protein-glutamine gamma-glutamyltransferase 2 (sprot)

description: A protein-glutamine gamma-glutamyltransferase 2 that is encoded in the genome of human.


protein-glutamine glutaminase activity

description: Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3.


histone serotonyltransferase activity

description: Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4(+).


histone dopaminyltransferase activity

description: Catalysis of the reaction: dopamine + L-glutaminyl-[histone] = 5-dopaminyl-L-glutamyl-[histone] + NH4(+).


description: Catalysis of the reaction: (R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+).


peptide histaminyltransferase activity

description: Catalysis of the reaction: histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein].


protein deamination

description: The removal of an amino group from a protein amino acid.


cellular response to serotonin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus.


regulation of apoptotic cell clearance

description: Any process that modulates the frequency, rate or extent of apoptotic cell clearance.


name: KCNA3_HUMAN Potassium voltage-gated channel subfamily A member 3 (sprot)

description: A voltage-gated potassium channel subunit KCNA3 that is encoded in the genome of human.


name: BMP5_HUMAN Bone morphogenetic protein 5 (sprot)

description: A bone morphogenetic protein 5 that is encoded in the genome of human.


name: BMP6_HUMAN Bone morphogenetic protein 6 (sprot)

description: A bone morphogenetic protein 6 that is encoded in the genome of human.


name: positive regulation of aldosterone biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.


name: positive regulation of aldosterone secretion

description: Any process that activates or increases the frequency, rate or extent of aldosterone secretion.


name: MUTA_HUMAN Methylmalonyl-CoA mutase, mitochondrial (sprot)

description: A methylmalonyl-CoA mutase, mitochondrial that is encoded in the genome of human.


methylmalonyl-CoA mutase activity

description: Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA.


succinyl-CoA biosynthetic process

description: The chemical reactions and pathways resulting in the formation of succinyl-CoA.


name: OSBP1_HUMAN Oxysterol-binding protein 1 (sprot)

description: An oxysterol-binding protein 1 that is encoded in the genome of human.


sterol transfer activity

description: Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


sterol transport

description: The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


ceramide transport

description: The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid.


name: positive regulation of secretory granule organization

description: Any process that activates or increases the frequency, rate or extent of secretory granule organization.


name: PIMT_HUMAN Protein-L-isoaspartate(D-aspartate) O-methyltransferase (sprot)

description: A protein-L-isoaspartate(D-aspartate) O-methyltransferase that is encoded in the genome of human.


name: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester.


protein repair

description: The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.


PERL_HUMAN Lactoperoxidase (sprot)

A lactoperoxidase that is encoded in the genome of human.


thiocyanate peroxidase activity

description: Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate.


thiocyanate metabolic process

description: The chemical reactions and pathways involving thiocyanate, the anion of thiocyanic acid, a toxic cyanide derivative commonly formed as a by-product in the production of gas for fuel, coke, and substances for chemical industries.


name: FUT4_HUMAN Alpha-(1,3)-fucosyltransferase 4 (sprot)

description: An alpha-(1,3)-fucosyltransferase 4 that is encoded in the genome of human.


lymphocyte migration into lymph node

description: The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen.


name: regulation of leukocyte cell-cell adhesion

description: Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion.


name: FBRL_HUMAN rRNA 2'-O-methyltransferase fibrillarin (sprot)

description: An rRNA 2'-O-methyltransferase fibrillarin that is encoded in the genome of human.


name: U6 snRNA 2'-O-ribose methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + U6 snRNA = S-adenosyl-L-homocysteine + U6 containing a 3'-terminal 2'-O-methylnucleotide + H+.


name: histone H2AQ104 methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-glutamine (position 104) = S-adenosyl-L-homocysteine + (histone H2A)-N5-methyl-glutamine (position 104). Note that this corresponds to Q105 in yeast.


rRNA methylation

description: The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.


snoRNA localization

description: Any process in which small nucleolar RNA is transported to, or maintained in, a specific location.


name: RS4Y1_HUMAN Small ribosomal subunit protein eS4, Y isoform 1 (sprot)

description: A small ribosomal subunit protein eS4, Y isoform 1 that is encoded in the genome of human.


name: PUR2_HUMAN Trifunctional purine biosynthetic protein adenosine-3 (sprot)

description: A trifunctional purine biosynthetic protein adenosine-3 that is encoded in the genome of human.


description: Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate.


description: Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate.


description: Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.


TENX_HUMAN Tenascin-X (sprot)

A tenascin-X that is encoded in the genome of human.


collagen fibril binding

description: Binding to a collagen fibril.


name: positive regulation of cell fate determination

description: Any process that activates or increases the frequency, rate or extent of cell fate determination.