LYAM3_HUMAN P-selectin (sprot)

A P-selectin that is encoded in the genome of human.


name: PGCA_HUMAN Aggrecan core protein (sprot)

description: An aggrecan core protein that is encoded in the genome of human.


name: F261_HUMAN 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (sprot)

description: A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 that is encoded in the genome of human.


category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.


fructose-6-phosphate binding

description: Binding to fructose 6-phosphate.


name: fructose 2,6-bisphosphate metabolic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.


category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.


ITB4_HUMAN Integrin beta-4 (sprot)

An integrin beta-4 that is encoded in the genome of human.


name: peripheral nervous system myelin formation

description: The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by Schwann cells in the peripheral nervous system.


trophoblast cell migration

description: Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst.


LEUK_HUMAN Leukosialin (sprot)

A leukosialin that is encoded in the genome of human.


response to protozoan

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan.


name: negative regulation of type IV hypersensitivity

description: Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response.


T-helper 1 cell lineage commitment

description: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis.


regulation of T cell migration

description: Any process that modulates the frequency, rate or extent of T cell migration.


name: CBR1_HUMAN Carbonyl reductase [NADPH] 1 (sprot)

description: A carbonyl reductase [NADPH] 1 that is encoded in the genome of human.


name: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate.


name: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H+ + NADPH.


prostaglandin E2 9-reductase activity

description: Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.


cyclooxygenase pathway

description: The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2.


ANK1_HUMAN Ankyrin-1 (sprot)

An ankyrin-1 that is encoded in the genome of human.


name: ACADS_HUMAN Short-chain specific acyl-CoA dehydrogenase, mitochondrial (sprot)

description: A short-chain specific acyl-CoA dehydrogenase, mitochondrial that is encoded in the genome of human.


butyryl-CoA dehydrogenase activity

description: Catalysis of the reaction: butanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein].


name: CREB1_HUMAN Cyclic AMP-responsive element-binding protein 1 (sprot)

description: A cyclic AMP-responsive element-binding protein 1 that is encoded in the genome of human.


hormone secretion

description: The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.


name: positive regulation of cardiac muscle tissue development

description: Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development.


ATF4-CREB1 transcription factor complex

description: Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway.


name: LIPP_HUMAN Pancreatic triacylglycerol lipase (sprot)

description: A pancreatic triacylglycerol lipase that is encoded in the genome of human.


name: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity

description: Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate.


name: positive regulation of triglyceride lipase activity

description: Any process that increases the activity of triglyceride lipase.


name: PGFRA_HUMAN Platelet-derived growth factor receptor alpha (sprot)

description: An alpha-type platelet-derived growth factor receptor that is encoded in the genome of human.


name: platelet-derived growth factor alpha-receptor activity

description: Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity.


name: regulation of mesenchymal stem cell differentiation

description: Any process that modulates the frequency, rate or extent of mesenchymal stem cell differentiation.


name: GDC_HUMAN Solute carrier family 25 member 16 (sprot)

description: A solute carrier family 25 member 16 that is encoded in the genome of human.


BGAL_HUMAN Beta-galactosidase (sprot)

A eukaryotic-type beta-galactosidase that is encoded in the genome of human.


beta-galactosidase activity

description: Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.


response to cortisone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues.


name: PECA1_HUMAN Platelet endothelial cell adhesion molecule (sprot)

description: A platelet endothelial cell adhesion molecule that is encoded in the genome of human.


monocyte extravasation

description: The migration of a monocyte from the blood vessels into the surrounding tissue.


name: positive regulation of protein localization to cell-cell junction

description: Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction.


name: PP2BB_HUMAN Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (sprot)

description: A serine/threonine-protein phosphatase 2B catalytic subunit beta isoform that is encoded in the genome of human.


name: calmodulin-dependent protein phosphatase activity

description: Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin.


calcium-ion regulated exocytosis

description: The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.


negative regulation of signaling

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.


name: negative regulation of calcium ion import across plasma membrane

description: Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane.


calcineurin complex

description: A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin.


name: protein serine/threonine phosphatase complex

description: A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein.


name: NCK1_HUMAN SH2/SH3 adapter protein NCK1 (sprot)

description: An SH2/SH3 adapter protein NCK1 that is encoded in the genome of human.


name: eukaryotic initiation factor eIF2 binding

description: Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation.


name: positive regulation of cap-dependent translational initiation

description: Any process that activates or increases the frequency, rate or extent of cap-dependent translational initiation.


name: positive regulation of cap-independent translational initiation

description: Any process that activates or increases the frequency, rate or extent of cap-independent translational initiation.


name: negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum stress-induced eiF2alpha phosphorylation.


name: GCFC2_HUMAN Intron Large complex component GCFC2 (sprot)

description: An intron Large complex component GCFC2 that is encoded in the genome of human.


name: KCNA2_HUMAN Potassium voltage-gated channel subfamily A member 2 (sprot)

description: A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of human.


name: voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

description: Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse.


name: voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

description: Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.


optic nerve structural organization

description: The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.


juxtaparanode region of axon

description: A region of an axon near a node of Ranvier that is between the paranode and internode regions.


H15_HUMAN Histone H1.5 (sprot)

A histone H1.5 that is encoded in the genome of human.


H13_HUMAN Histone H1.3 (sprot)

A histone H1.3 that is encoded in the genome of human.


H12_HUMAN Histone H1.2 (sprot)

A histone H1.2 that is encoded in the genome of human.


name: CTLA4_HUMAN Cytotoxic T-lymphocyte protein 4 (sprot)

description: A cytotoxic T-lymphocyte protein 4 that is encoded in the genome of human.


name: ZN823_HUMAN Zinc finger protein 823 (sprot)

description: A zinc finger protein 823 that is encoded in the genome of human.


name: EPCAM_HUMAN Epithelial cell adhesion molecule (sprot)

description: An epithelial cell adhesion molecule that is encoded in the genome of human.


name: NCPR_HUMAN NADPH--cytochrome P450 reductase (sprot)

description: An NADPH--cytochrome P450 reductase that is encoded in the genome of human.


NADPH-hemoprotein reductase activity

description: Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.


electron transport chain

description: A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.


name: positive regulation of monooxygenase activity

description: Any process that activates or increases the activity of a monooxygenase.


name: cellular organofluorine metabolic process

description: The chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells.


name: BGAT_HUMAN Histo-blood group ABO system transferase (sprot)

description: A histo-blood group ABO system transferase that is encoded in the genome of human.


description: Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.


DPEP1_HUMAN Dipeptidase 1 (sprot)

A dipeptidase 1 that is encoded in the genome of human.


beta-lactamase activity

description: Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid.


dipeptidase activity

description: Catalysis of the hydrolysis of a dipeptide.


modified amino acid binding

description: Binding to a modified amino acid.


antibiotic metabolic process

description: The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.


homocysteine metabolic process

description: The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.


lactam catabolic process

description: The chemical reactions and pathways resulting in the breakdown of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.


leukotriene D4 catabolic process

description: The chemical reactions and pathways resulting in the breakdown of leukotriene D4.


EPB42_HUMAN Protein 4.2 (sprot)

A protein 4.2 that is encoded in the genome of human.


name: MGMT_HUMAN Methylated-DNA--protein-cysteine methyltransferase (sprot)

description: A methylated-DNA--protein-cysteine methyltransferase that is encoded in the genome of human.


DNA-methyltransferase activity

description: Catalysis of the transfer of a methyl group to a DNA molecule.


DNA alkylation repair

description: The repair of alkylation damage in DNA, e.g. the removal of a non-physiological alkyl group from a nucleobase. This is usually mediated by DNA alkyltransferases.


PRLR_HUMAN Prolactin receptor (sprot)

A prolactin receptor that is encoded in the genome of human.


prolactin receptor activity

description: Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


TSHR_HUMAN Thyrotropin receptor (sprot)

A thyrotropin receptor that is encoded in the genome of human.


name: thyroid-stimulating hormone receptor activity

description: Combining with thyroid-stimulating hormone to initiate a change in cell activity.


name: thyroid-stimulating hormone signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A G protein-coupled receptor signaling pathway initiated by thyroid-stimulating hormone (thyrotropin) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


cellular response to glycoprotein

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.


name: cellular response to thyrotropin-releasing hormone

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.


name: PDE6A_HUMAN Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (sprot)

description: A rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha that is encoded in the genome of human.


name: NEC2_HUMAN Neuroendocrine convertase 2 (sprot)

description: A neuroendocrine convertase 2 that is encoded in the genome of human.


islet amyloid polypeptide processing

description: The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP).


name: GBB3_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (sprot)

description: A guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 that is encoded in the genome of human.


name: regulation of triglyceride metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol.


name: regulation of phospholipid metabolic process

description: Any process that modulates the frequency, rate or extent of phospholipid metabolic process.


LYAM2_HUMAN E-selectin (sprot)

An E-selectin that is encoded in the genome of human.


actin filament-based process

description: Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.


name: FER_HUMAN Tyrosine-protein kinase Fer (sprot)

description: A tyrosine-protein kinase Fer that is encoded in the genome of human.


regulation of lamellipodium assembly

description: Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.


name: response to platelet-derived growth factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.


adherens junction disassembly

description: The disaggregation of an adherens junction into its constituent components. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.


name: AT2A2_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (sprot)

description: A sarcoplasmic/endoplasmic reticulum calcium ATPase 2 that is encoded in the genome of human.


name: P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

description: A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential.


ER-nucleus signaling pathway

description: The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.


name: regulation of cardiac muscle cell action potential involved in regulation of contraction

description: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction.


name: regulation of calcium ion-dependent exocytosis of neurotransmitter

description: Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter.


name: calcium ion transport from cytosol to endoplasmic reticulum

description: The directed movement of calcium ion from cytosol to endoplasmic reticulum.


name: CL3L1_HUMAN C-C motif chemokine 3-like 1 (sprot)

description: A C-C motif chemokine 3-like 1 that is encoded in the genome of human.


name: UD2B7_HUMAN UDP-glucuronosyltransferase 2B7 (sprot)

description: A UDP-glucuronosyltransferase 2B7 that is encoded in the genome of human.


name: CD36_HUMAN Platelet glycoprotein 4 (sprot)

description: A platelet glycoprotein 4 that is encoded in the genome of human.


name: short-chain fatty acid transmembrane transporter activity

description: Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.


name: lipoteichoic acid immune receptor activity

description: Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response.


name: oxidised low-density lipoprotein particle receptor activity

description: Combining with an oxidised low-density lipoprotein particle and delivering the oxidised low-density lipoprotein particle into the cell via endocytosis.


short-chain fatty acid transport

description: The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.


response to linoleic acid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus.


cellular response to hydroperoxide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.


regulation of action potential

description: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


name: oxidised low-density lipoprotein particle clearance

description: The process in which an oxidised low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


name: lipid transport across blood-brain barrier

description: The directed movement of lipid molecules passing through the blood-brain barrier.


name: ANFB_HUMAN Natriuretic peptides B (sprot)

description: A natriuretic peptides B that is encoded in the genome of human.


diuretic hormone activity

description: The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion.


CBPE_HUMAN Carboxypeptidase E (sprot)

A carboxypeptidase E that is encoded in the genome of human.


cardiac left ventricle morphogenesis

description: The process in which the left cardiac ventricle is generated and organized.


name: IL7RA_HUMAN Interleukin-7 receptor subunit alpha (sprot)

description: An interleukin-7 receptor subunit alpha that is encoded in the genome of human.


interleukin-7 receptor activity

description: Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


regulation of DNA recombination

description: Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.


name: PLCG2_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (sprot)

description: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 that is encoded in the genome of human.


phospholipase C activity

description: Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.


follicular B cell differentiation

description: The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region.


name: inositol trisphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.


cellular response to lipid

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.


cellular response to lectin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties.


FAAA_HUMAN Fumarylacetoacetase (sprot)

A fumarylacetoacetase that is encoded in the genome of human.


STMN1_HUMAN Stathmin (sprot)

A stathmin that is encoded in the genome of human.


name: YBOX3_HUMAN Y-box-binding protein 3 (sprot)

description: A Y-box-binding protein 3 that is encoded in the genome of human.


name: ZFX_HUMAN Zinc finger X-chromosomal protein (sprot)

description: A zinc finger X-chromosomal protein that is encoded in the genome of human.


parental behavior

description: A reproductive behavior in which a parent cares for and rears offspring.


name: ZNF12_HUMAN Zinc finger protein 12 (sprot)

description: A zinc finger protein 12 that is encoded in the genome of human.


name: ZNF14_HUMAN Zinc finger protein 14 (sprot)

description: A zinc finger protein 14 that is encoded in the genome of human.


name: ZN708_HUMAN Zinc finger protein 708 (sprot)

description: A zinc finger protein 708 that is encoded in the genome of human.


name: ZNF16_HUMAN Zinc finger protein 16 (sprot)

description: A zinc finger protein 16 that is encoded in the genome of human.


name: positive regulation of megakaryocyte differentiation

description: Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.


name: cellular response to sodium dodecyl sulfate

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus.


name: positive regulation of cell cycle phase transition

description: Any process that activates or increases the frequency, rate or extent of cell cycle phase transition.


name: ZNF17_HUMAN Zinc finger protein 17 (sprot)

description: A zinc finger protein 17 that is encoded in the genome of human.


name: ZNF18_HUMAN Zinc finger protein 18 (sprot)

description: A zinc finger protein 18 that is encoded in the genome of human.


name: ZNF19_HUMAN Zinc finger protein 19 (sprot)

description: A zinc finger protein 19 that is encoded in the genome of human.


name: ZNF20_HUMAN Zinc finger protein 20 (sprot)

description: A zinc finger protein 20 that is encoded in the genome of human.


name: ZN182_HUMAN Zinc finger protein 182 (sprot)

description: A zinc finger protein 182 that is encoded in the genome of human.


name: ZNF22_HUMAN Zinc finger protein 22 (sprot)

description: A zinc finger protein 22 that is encoded in the genome of human.


name: ZNF23_HUMAN Zinc finger protein 23 (sprot)

description: A zinc finger protein 23 that is encoded in the genome of human.


name: ZNF24_HUMAN Zinc finger protein 24 (sprot)

description: A zinc finger protein 24 that is encoded in the genome of human.


name: ZKSC1_HUMAN Zinc finger protein with KRAB and SCAN domains 1 (sprot)

description: A zinc finger protein with KRAB and SCAN domains 1 that is encoded in the genome of human.


name: ZNF25_HUMAN Zinc finger protein 25 (sprot)

description: A zinc finger protein 25 that is encoded in the genome of human.


name: ZNF26_HUMAN Zinc finger protein 26 (sprot)

description: A zinc finger protein 26 that is encoded in the genome of human.


name: ZN37A_HUMAN Zinc finger protein 37A (sprot)

description: A zinc finger protein 37A that is encoded in the genome of human.


name: ZNF28_HUMAN Zinc finger protein 28 (sprot)

description: A zinc finger protein 28 that is encoded in the genome of human.


name: ZNF3_HUMAN Zinc finger protein 3 (sprot)

description: A zinc finger protein 3 that is encoded in the genome of human.


name: ZNF43_HUMAN Zinc finger protein 43 (sprot)

description: A zinc finger protein 43 that is encoded in the genome of human.


name: ZNF30_HUMAN Zinc finger protein 30 (sprot)

description: A zinc finger protein 30 that is encoded in the genome of human.


name: ZSC20_HUMAN Zinc finger and SCAN domain-containing protein 20 (sprot)

description: A zinc finger and SCAN domain-containing protein 20 that is encoded in the genome of human.


name: ZNF32_HUMAN Zinc finger protein 32 (sprot)

description: A zinc finger protein 32 that is encoded in the genome of human.


An alpha-N-acetylgalactosaminidase that is encoded in the genome of human.


description: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides.


name: HSP76_HUMAN Heat shock 70 kDa protein 6 (sprot)

description: A heat shock 70 kDa protein 6 that is encoded in the genome of human.


name: RHOQ_HUMAN Rho-related GTP-binding protein RhoQ (sprot)

description: A Rho-related GTP-binding protein RhoQ that is encoded in the genome of human.


GBD domain binding

description: Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac.


name: HMGA1_HUMAN High mobility group protein HMG-I/HMG-Y (sprot)

description: A high mobility group protein HMG-I/HMG-Y that is encoded in the genome of human.


description: A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes.


name: ZNF7_HUMAN Zinc finger protein 7 (sprot)

description: A zinc finger protein 7 that is encoded in the genome of human.


name: ZNF8_HUMAN Zinc finger protein 8 (sprot)

description: A zinc finger protein 8 that is encoded in the genome of human.


name: TMM11_HUMAN Transmembrane protein 11, mitochondrial (sprot)

description: A transmembrane protein 11, mitochondrial that is encoded in the genome of human.


name: AATC_HUMAN Aspartate aminotransferase, cytoplasmic (sprot)

description: An aspartate aminotransferase, cytoplasmic that is encoded in the genome of human.


description: Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine.


L-cysteine transaminase activity

description: Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.


name: INAR1_HUMAN Interferon alpha/beta receptor 1 (sprot)

description: An interferon-alpha/beta receptor alpha chain that is encoded in the genome of human.


type I interferon receptor activity

description: Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.


type I interferon binding

description: Binding to a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.


name: BPI_HUMAN Bactericidal permeability-increasing protein (sprot)

description: A bactericidal permeability-increasing protein that is encoded in the genome of human.


name: negative regulation of macrophage activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation.


name: KPCA_HUMAN Protein kinase C alpha type (sprot)

description: A protein kinase C alpha type that is encoded in the genome of human.


name: positive regulation of angiotensin-activated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the angiotensin-activated signaling pathway.


name: JUNB_HUMAN Transcription factor JunB (sprot)

description: A transcription factor JunB that is encoded in the genome of human.


name: regulation of T-helper 17 cell differentiation

description: Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation.


ITA2_HUMAN Integrin alpha-2 (sprot)

An integrin alpha-2 that is encoded in the genome of human.


collagen receptor activity

description: Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


substrate-dependent cell migration

description: The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.


hypotonic response

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.


name: positive regulation of cell projection organization

description: Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.


name: positive regulation of transmission of nerve impulse

description: Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.


name: CXA1_HUMAN Gap junction alpha-1 protein (sprot)

description: A gap junction alpha-1 protein that is encoded in the genome of human.


gap junction hemi-channel activity

description: A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction.


name: gap junction channel activity involved in cardiac conduction electrical coupling

description: A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


atrial ventricular junction remodeling

description: The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle.


cell communication by chemical coupling

description: The process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels.


name: negative regulation of gonadotropin secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin.


name: positive regulation of striated muscle tissue development

description: Any process that activates or increases the frequency, rate or extent of striated muscle development.


milk ejection reflex

description: A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness.


cellular response to pH

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.


name: positive regulation of morphogenesis of an epithelium

description: Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium.


name: positive regulation of mesodermal cell differentiation

description: Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation.


connexin complex

description: An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.


name: ANPRC_HUMAN Atrial natriuretic peptide receptor 3 (sprot)

description: An atrial natriuretic peptide receptor 3 that is encoded in the genome of human.


regulation of osteoblast proliferation

description: Any process that modulates the frequency, rate or extent of osteoblast proliferation.


name: ASM_HUMAN Sphingomyelin phosphodiesterase (sprot)

description: A sphingomyelin phosphodiesterase that is encoded in the genome of human.


name: phosphatidylcholine phospholipase C activity

description: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H+ + phosphocholine.


name: acid sphingomyelin phosphodiesterase activity

description: Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in an acidic environment.


sphingomyelin metabolic process

description: The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.


endolysosome

description: An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place.


name: UBF1_HUMAN Nucleolar transcription factor 1 (sprot)

description: A nucleolar transcription factor 1 that is encoded in the genome of human.


name: RNA polymerase I core promoter sequence-specific DNA binding

description: Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.


name: RNA polymerase I cis-regulatory region sequence-specific DNA binding

description: Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element).


name: RNA polymerase I general transcription initiation factor activity

description: A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs.


name: HXB8_HUMAN Homeobox protein Hox-B8 (sprot)

description: A homeobox protein Hox-B8 that is encoded in the genome of human.


name: HXB9_HUMAN Homeobox protein Hox-B9 (sprot)

description: A homeobox protein Hox-B9 that is encoded in the genome of human.


name: HXB4_HUMAN Homeobox protein Hox-B4 (sprot)

description: A homeobox protein Hox-B4 that is encoded in the genome of human.


name: HXB6_HUMAN Homeobox protein Hox-B6 (sprot)

description: A homeobox protein Hox-B6 that is encoded in the genome of human.


name: AK1C4_HUMAN Aldo-keto reductase family 1 member C4 (sprot)

description: An aldo-keto reductase family 1 member C4 that is encoded in the genome of human.


chlordecone reductase activity

description: Catalysis of the reaction: chlordecone alcohol + NADP+ = chlordecone + H+ + NADPH.


name: cellular response to jasmonic acid stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.


name: JUND_HUMAN Transcription factor JunD (sprot)

description: A transcription factor JunD that is encoded in the genome of human.


CTRB1_HUMAN Chymotrypsinogen B (sprot)

A chymotrypsinogen B that is encoded in the genome of human.


name: KCRS_HUMAN Creatine kinase S-type, mitochondrial (sprot)

description: A creatine kinase S-type, mitochondrial that is encoded in the genome of human.


name: TAL1_HUMAN T-cell acute lymphocytic leukemia protein 1 (sprot)

description: A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of human.


astrocyte fate commitment

description: The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte.


hemangioblast cell differentiation

description: The process in which a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages.


regulation of mast cell differentiation

description: Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.


name: positive regulation of chromatin organization

description: Any process that activates or increases the frequency, rate or extent of chromatin organization.


name: ATF7_HUMAN Cyclic AMP-dependent transcription factor ATF-7 (sprot)

description: A cyclic AMP-dependent transcription factor ATF-7 that is encoded in the genome of human.


name: NDUB7_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 that is encoded in the genome of human.


SYN1_HUMAN Synapsin-1 (sprot)

A synapsin-1 that is encoded in the genome of human.


regulation of synaptic vesicle cycle

description: Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle.


name: KAPCA_HUMAN cAMP-dependent protein kinase catalytic subunit alpha (sprot)

description: A cAMP-dependent protein kinase catalytic subunit alpha that is encoded in the genome of human.


cAMP-dependent protein kinase activity

description: cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


name: cellular response to epinephrine stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.


protein localization to lipid droplet

description: A process in which a protein is transported to, or maintained in, a location on or within a lipid droplet.


name: TYRP1_HUMAN 5,6-dihydroxyindole-2-carboxylic acid oxidase (sprot)

description: A 5,6-dihydroxyindole-2-carboxylic acid oxidase that is encoded in the genome of human.


acetoacetic acid metabolic process

description: The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH.


name: CAN2_HUMAN Calpain-2 catalytic subunit (sprot)

description: A calpain-2 catalytic subunit that is encoded in the genome of human.


name: KCNA6_HUMAN Potassium voltage-gated channel subfamily A member 6 (sprot)

description: A voltage-gated potassium channel subunit KCNA6 that is encoded in the genome of human.


DESM_HUMAN Desmin (sprot)

A desmin that is encoded in the genome of human.


cell tip

description: The region at the end of the longest axis of a cylindrical or elongated cell.


name: CEBPB_HUMAN CCAAT/enhancer-binding protein beta (sprot)

description: A CCAAT/enhancer-binding protein beta that is encoded in the genome of human.


name: positive regulation of biomineral tissue development

description: Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.


name: positive regulation of sodium-dependent phosphate transport

description: Any process that activates or increases the frequency, rate or extent of sodium-dependent phosphate transport.


name: regulation of odontoblast differentiation

description: Any process that modulates the frequency, rate or extent of odontoblast differentiation.


CHOP-C/EBP complex

description: A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors.


C/EBP complex

description: A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities.


NEUM_HUMAN Neuromodulin (sprot)

A neuromodulin that is encoded in the genome of human.


growth cone membrane

description: The portion of the plasma membrane surrounding a growth cone.


name: HLAG_HUMAN HLA class I histocompatibility antigen, alpha chain G (sprot)

description: An MHC class I histocompatibility antigen, alpha chain G that is encoded in the genome of human.


peripheral B cell tolerance induction

description: Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue.


name: positive regulation of tolerance induction

description: Any process that activates or increases the frequency, rate, or extent of tolerance induction.


name: immune response-inhibiting cell surface receptor signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of inhibiting an immune response.


name: negative regulation of dendritic cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation.


cis-Golgi network membrane

description: The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network.


name: PTN2_HUMAN Tyrosine-protein phosphatase non-receptor type 2 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 2 that is encoded in the genome of human.


name: regulation of type II interferon-mediated signaling pathway

description: Any process that modulates the rate, frequency or extent of an interferon-gamma-mediated signaling pathway.


name: negative regulation of interleukin-6-mediated signaling pathway

description: Any process that decreases the rate, frequency or extent of an interleukin-6-mediated signaling pathway.


name: regulation of hepatocyte growth factor receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway.


name: negative regulation of interleukin-2-mediated signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2-mediated signaling pathway.


name: negative regulation of interleukin-4-mediated signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-4-mediated signaling pathway.


name: negative regulation of macrophage colony-stimulating factor signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway.


name: negative regulation of positive thymic T cell selection

description: Any process that stops, prevents or reduces the frequency, rate or extent of positive thymic T cell selection.


name: negative regulation of platelet-derived growth factor receptor-beta signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway.


name: DCAM_HUMAN S-adenosylmethionine decarboxylase proenzyme (sprot)

description: A SAM decarboxylase proenzyme that is encoded in the genome of human.


description: Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2.


name: ATTY_HUMAN Tyrosine aminotransferase (sprot)

description: A tyrosine aminotransferase that is encoded in the genome of human.


description: Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.


name: TPH1_HUMAN Tryptophan 5-hydroxylase 1 (sprot)

description: A tryptophan 5-hydroxylase 1 that is encoded in the genome of human.


aromatic amino acid metabolic process

description: The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).


serotonin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.


regulation of hemostasis

description: Any process that modulates the frequency, rate or extent of hemostasis.


name: ACHB2_HUMAN Neuronal acetylcholine receptor subunit beta-2 (sprot)

description: A neuronal acetylcholine receptor subunit beta-2 that is encoded in the genome of human.


quaternary ammonium group binding

description: Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.


vestibulocochlear nerve development

description: The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.


lateral geniculate nucleus development

description: The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina.


name: regulation of synaptic transmission, dopaminergic

description: Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.


name: positive regulation of dopamine secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine.


name: regulation of circadian sleep/wake cycle, REM sleep

description: Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep.


negative regulation of action potential

description: Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


name: synaptic transmission involved in micturition

description: The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body.


response to acetylcholine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus.


PYRG1_HUMAN CTP synthase 1 (sprot)

A CTP synthase 1 that is encoded in the genome of human.


CTP synthase activity

description: Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate.


'de novo' CTP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components.


cytoophidium

description: A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human.


EGLN_HUMAN Endoglin (sprot)

An endoglin that is encoded in the genome of human.


name: endocardial cushion to mesenchymal transition

description: A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


signaling receptor activator activity

description: The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased.


cardiac ventricle morphogenesis

description: The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.


cardiac atrium morphogenesis

description: The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.


venous blood vessel morphogenesis

description: The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart.


name: extracellular matrix constituent secretion

description: The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell.


name: positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

description: Any process that activates or increases the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation.


name: DDX5_HUMAN Probable ATP-dependent RNA helicase DDX5 (sprot)

description: A probable ATP-dependent RNA helicase DDX5 that is encoded in the genome of human.


MH2 domain binding

description: Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers.


primary miRNA processing

description: A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule.


miRNA transcription

description: The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation.


name: regulation of skeletal muscle cell differentiation

description: Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.


name: PFKAL_HUMAN ATP-dependent 6-phosphofructokinase, liver type (sprot)

description: An ATP-dependent 6-phosphofructokinase, liver type that is encoded in the genome of human.


name: XBP1_HUMAN X-box-binding protein 1 (sprot)

description: An X-box-binding protein 1 that is encoded in the genome of human.


sterol homeostasis

description: Any process involved in the maintenance of an internal steady state of sterol within an organism or cell.


cellular response to fructose stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus.


name: positive regulation of plasma cell differentiation

description: Any process that activates or increases the frequency, rate or extent of plasma cell differentiation.


positive regulation of lactation

description: Any process that activates or increases the frequency, rate or extent of lactation.


name: response to insulin-like growth factor stimulus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.


name: SAP3_HUMAN Ganglioside GM2 activator (sprot)

description: A ganglioside GM2 activator that is encoded in the genome of human.


sphingolipid activator protein activity

description: Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase.


beta-N-acetylgalactosaminidase activity

description: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides.


name: CR1_HUMAN Complement receptor type 1 (sprot)

description: A complement receptor type 1 that is encoded in the genome of human.


name: negative regulation of activation of membrane attack complex

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.


name: negative regulation of plasma cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of plasma cell differentiation.


ATP export

description: The directed movement of ATP out of a cell or organelle.


name: complement component C4b receptor activity

description: Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: complement component C3b receptor activity

description: Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


description: The process of immune complex clearance by erythrocytes. The process often starts with binding of complement receptor 1 (CR1) on the surface of erythrocytes to a complement coated immune complex. The complex bound to erythrocyte CR1 is then transported to the liver or spleen where it is presented to phagocytes. The process ends when the complex is removed from CR1, allowing the erythrocyte to return to general circulation.


name: negative regulation of complement activation, alternative pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway.


LEG3_HUMAN Galectin-3 (sprot)

A galectin-3 that is encoded in the genome of human.


negative regulation of endocytosis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.


regulation of T cell apoptotic process

description: Any process that modulates the occurrence or rate of T cell death by apoptotic process.


name: regulation of extrinsic apoptotic signaling pathway via death domain receptors

description: Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.


name: negative regulation of protein tyrosine phosphatase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein tyrosine phosphatase activity.


name: negative regulation of immunological synapse formation

description: Any process that stops, prevents or reduces the frequency, rate or extent of immunological synapse formation.


name: negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

description: Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell.


name: IBP3_HUMAN Insulin-like growth factor-binding protein 3 (sprot)

description: An insulin-like growth factor-binding protein 3 that is encoded in the genome of human.


name: protein tyrosine phosphatase activator activity

description: Binds to and increases the activity of a phosphotyrosine phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein.


name: SPI1_HUMAN Transcription factor PU.1 (sprot)

description: A transcription factor PU.1 that is encoded in the genome of human.


NFAT protein binding

description: Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.


pro-T cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed.


myeloid leukocyte differentiation

description: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.


endothelial to hematopoietic transition

description: The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium.


name: negative regulation of protein localization to chromatin

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin.


name: positive regulation of antifungal innate immune response

description: Any process that activates or increases the frequency, rate or extent of an antifungal innate immune response.


name: regulation of myeloid progenitor cell differentiation

description: Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation.


name: VGFR1_HUMAN Vascular endothelial growth factor receptor 1 (sprot)

description: A vascular endothelial growth factor receptor 1 that is encoded in the genome of human.


name: placental growth factor receptor activity

description: Combining with placental growth factor (PlGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.


name: vascular endothelial growth factor receptor-1 signaling pathway

description: The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-1 (VEGFR-1) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: PRS6A_HUMAN 26S proteasome regulatory subunit 6A (sprot)

description: A 26S proteasome regulatory subunit 6A that is encoded in the genome of human.


proteasome-activating activity

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.


name: modulation by host of viral transcription

description: Any process in which a host organism modulates the frequency, rate or extent of viral transcription.


name: TCPA_HUMAN T-complex protein 1 subunit alpha (sprot)

description: A T-complex protein 1 subunit alpha that is encoded in the genome of human.


chaperonin-containing T-complex

description: A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.


zona pellucida receptor complex

description: A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.


name: PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 1 that is encoded in the genome of human.


name: regulation of type I interferon-mediated signaling pathway

description: Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway.


name: positive regulation of receptor catabolic process

description: Any process that activates or increases the frequency, rate or extent of receptor catabolic process.


name: cytoplasmic side of endoplasmic reticulum membrane

description: The side (leaflet) of the plasma membrane that faces the cytoplasm.


name: LOX12_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX12 (sprot)

description: A polyunsaturated fatty acid lipoxygenase ALOX12 that is encoded in the genome of human.


leukotriene A4 metabolic process

description: The chemical reactions and pathways involving leukotriene A4.


hepoxilin-epoxide hydrolase activity

description: Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate.


name: unsaturated fatty acid metabolic process

description: The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.


lipoxin B4 biosynthetic process

description: The chemical reactions and pathways resulting in the formation of lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds.


name: IBP2_HUMAN Insulin-like growth factor-binding protein 2 (sprot)

description: An insulin-like growth factor-binding protein 2 that is encoded in the genome of human.


name: regulation of insulin-like growth factor receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling.


name: ERCC2_HUMAN General transcription and DNA repair factor IIH helicase subunit XPD (sprot)

description: A general transcription and DNA repair factor IIH helicase subunit XPD that is encoded in the genome of human.


5'-3' DNA helicase activity

description: Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis.


name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.


name: transcription elongation by RNA polymerase I

description: The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I.


hair follicle maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state.


transcription factor TFIIH core complex

description: The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD.


transcription factor TFIIH holo complex

description: A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex.


CAK-ERCC2 complex

description: A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2.


name: BMP7_HUMAN Bone morphogenetic protein 7 (sprot)

description: A bone morphogenetic protein 7 that is encoded in the genome of human.


pericardium morphogenesis

description: The process in which the anatomical structure of the pericardium is generated and organized.


neural fold elevation formation

description: The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm.


heart trabecula morphogenesis

description: The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.


name: negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis

description: Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron.


metanephric mesenchyme morphogenesis

description: The process in which the anatomical structures of a metanephric mesenchymal tissue are generated and organized. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros.


nephrogenic mesenchyme morphogenesis

description: The process in which the anatomical structures of a nephrogenic mesenchymal tissue are generated and organized. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron.


name: metanephric mesenchymal cell proliferation involved in metanephros development

description: The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population.


name: mesenchymal cell apoptotic process involved in nephron morphogenesis

description: Any mesenchymal cell apoptotic process that is involved in nephron morphogenesis.


allantois development

description: The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure.


name: RL35A_HUMAN Large ribosomal subunit protein eL33 (sprot)

description: A large ribosomal subunit protein eL33 that is encoded in the genome of human.


ITB5_HUMAN Integrin beta-5 (sprot)

An integrin beta-5 that is encoded in the genome of human.


name: ARF4_HUMAN ADP-ribosylation factor 4 (sprot)

description: An ADP-ribosylation factor 4 that is encoded in the genome of human.


description: Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide.


phospholipase D activator activity

description: Binds to and increases the activity of the enzyme phospholipase D.


name: establishment or maintenance of epithelial cell apical/basal polarity

description: Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.


name: ADA2B_HUMAN Alpha-2B adrenergic receptor (sprot)

description: An alpha-2B adrenergic receptor that is encoded in the genome of human.


name: regulation of vascular associated smooth muscle contraction

description: Any process that increases the frequency, rate or extent of vascular smooth muscle contraction.


name: RL7_HUMAN Large ribosomal subunit protein uL30 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL30 that is encoded in the genome of human.


name: EGR1_HUMAN Early growth response protein 1 (sprot)

description: An early growth response protein 1 that is encoded in the genome of human.


hemi-methylated DNA-binding

description: Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.


regulation of protein sumoylation

description: Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein.


name: positive regulation of hormone biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.


circadian temperature homeostasis

description: Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours.


glomerular mesangial cell proliferation

description: The multiplication or reproduction of glomerular mesangial cells, resulting in the expansion of the population.


name: positive regulation of glomerular metanephric mesangial cell proliferation

description: Any process that increases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation.


cellular response to interleukin-8

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus.


name: positive regulation of post-translational protein modification

description: Any process that activates or increases the frequency, rate or extent of post-translational protein modification.


name: regulation of progesterone biosynthetic process

description: Any process that modulates the frequency, rate or extent of progesterone biosynthetic process.


VINC_HUMAN Vinculin (sprot)

A vinculin that is encoded in the genome of human.


name: regulation of protein localization to adherens junction

description: Any process that modulates the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.


podosome ring

description: The ring structure surrounding the podosome core, containing proteins such as vinculin and talin.


name: GPX2_HUMAN Glutathione peroxidase 2 (sprot)

description: A glutathione peroxidase 2 that is encoded in the genome of human.


name: S5A1_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (sprot)

description: A 3-oxo-5-alpha-steroid 4-dehydrogenase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor.


amide binding

description: Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.


name: 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity

description: Catalysis of the reaction: 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-delta(4)-steroid + H+ + NADPH.


name: response to follicle-stimulating hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus.


name: LBP_HUMAN Lipopolysaccharide-binding protein (sprot)

description: A lipopolysaccharide-binding protein that is encoded in the genome of human.


lipopeptide binding

description: Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids.


lipopolysaccharide transport

description: The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.


name: positive regulation of respiratory burst involved in inflammatory response

description: Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.


name: PTPRA_HUMAN Receptor-type tyrosine-protein phosphatase alpha (sprot)

description: A receptor-type tyrosine-protein phosphatase alpha that is encoded in the genome of human.


name: ARY1_HUMAN Arylamine N-acetyltransferase 1 (sprot)

description: An arylamine N-acetyltransferase 1 that is encoded in the genome of human.


name: GBRB1_HUMAN Gamma-aminobutyric acid receptor subunit beta-1 (sprot)

description: A gamma-aminobutyric acid receptor subunit beta-1 that is encoded in the genome of human.


name: G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential

description: G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential.


name: GBRG2_HUMAN Gamma-aminobutyric acid receptor subunit gamma-2 (sprot)

description: A gamma-aminobutyric acid receptor subunit gamma-2 that is encoded in the genome of human.


name: PACA_HUMAN Pituitary adenylate cyclase-activating polypeptide (sprot)

description: A pituitary adenylate cyclase-activating polypeptide that is encoded in the genome of human.


name: pituitary adenylate cyclase activating polypeptide activity

description: The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation.


name: IL1RA_HUMAN Interleukin-1 receptor antagonist protein (sprot)

description: An interleukin-1 receptor antagonist protein that is encoded in the genome of human.


interleukin-1, type I receptor binding

description: Binding to a Type I interleukin-1 receptor.


interleukin-1, type II receptor binding

description: Binding to a Type II interleukin-1 receptor.


name: interleukin-1 receptor antagonist activity

description: Blocks the binding of interleukin-1 to the interleukin-1 receptor complex.


name: interleukin-1 type I receptor antagonist activity

description: Blocks the binding of interleukin-1 to interleukin-1 type I receptors.


name: interleukin-1 type II receptor antagonist activity

description: Blocks the binding of interleukin-1 to interleukin-1 type II receptors.


name: CNRG_HUMAN Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (sprot)

description: A retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma that is encoded in the genome of human.


ITB6_HUMAN Integrin beta-6 (sprot)

An integrin beta-6 that is encoded in the genome of human.


name: RHCE_HUMAN Blood group Rh(CE) polypeptide (sprot)

description: A blood group Rh(CE) polypeptide that is encoded in the genome of human.


SON_HUMAN Protein SON (sprot)

A SON protein that is encoded in the genome of human.


name: NELFE_HUMAN Negative elongation factor E (sprot)

description: A negative elongation factor E that is encoded in the genome of human.


NELF complex

description: A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing.


name: RL17_HUMAN Large ribosomal subunit protein uL22 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL22 that is encoded in the genome of human.


name: LAG3_HUMAN Lymphocyte activation gene 3 protein (sprot)

description: A lymphocyte activation gene 3 protein that is encoded in the genome of human.


plasmacytoid dendritic cell activation

description: A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand.


name: PGAM1_HUMAN Phosphoglycerate mutase 1 (sprot)

description: A phosphoglycerate mutase 1 that is encoded in the genome of human.


name: RCC1_HUMAN Regulator of chromosome condensation (sprot)

description: A regulator of chromosome condensation that is encoded in the genome of human.


name: ADA2C_HUMAN Alpha-2C adrenergic receptor (sprot)

description: An alpha-2C adrenergic receptor that is encoded in the genome of human.


SDC1_HUMAN Syndecan-1 (sprot)

A syndecan-1 that is encoded in the genome of human.


name: ATF1_HUMAN Cyclic AMP-dependent transcription factor ATF-1 (sprot)

description: A cyclic AMP-dependent transcription factor ATF-1 that is encoded in the genome of human.


ATF1-ATF4 transcription factor complex

description: Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway.


name: ATF3_HUMAN Cyclic AMP-dependent transcription factor ATF-3 (sprot)

description: A cyclic AMP-dependent transcription factor ATF-3 that is encoded in the genome of human.


name: positive regulation of TRAIL-activated apoptotic signaling pathway

description: Any process that activates or increases the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway.


CHOP-ATF3 complex

description: A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits.


name: ATF4_HUMAN Cyclic AMP-dependent transcription factor ATF-4 (sprot)

description: A cyclic AMP-dependent transcription factor ATF-4 that is encoded in the genome of human.


L-asparagine metabolic process

description: The chemical reactions and pathways involving L-asparagine, (2S)-2-amino-3-carbamoylpropanoic acid.


Lewy body core

description: The center portion of a Lewy body. In Parkinson's disease, it contains a matted meshwork of filaments.


CHOP-ATF4 complex

description: A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits.


name: ATF6A_HUMAN Cyclic AMP-dependent transcription factor ATF-6 alpha (sprot)

description: A cyclic AMP-dependent transcription factor ATF-6 alpha that is encoded in the genome of human.


name: positive regulation of ATF6-mediated unfolded protein response

description: Any process that activates or increases the frequency, rate or extent of the ATF6-mediated unfolded protein response.


DNLI1_HUMAN DNA ligase 1 (sprot)

A DNA ligase 1 that is encoded in the genome of human.


DNA ligase activity

description: Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+.


name: ATP5J_HUMAN ATP synthase-coupling factor 6, mitochondrial (sprot)

description: An ATP synthase-coupling factor 6, mitochondrial that is encoded in the genome of human.


name: XRCC1_HUMAN DNA repair protein XRCC1 (sprot)

description: A DNA repair protein XRCC1 that is encoded in the genome of human.


oxidized DNA binding

description: Binding to a DNA region containing an oxidized residue.


name: ADP-D-ribose modification-dependent protein binding

description: Binding to a protein upon ADP-ribosylation of the target protein.


voluntary musculoskeletal movement

description: The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will.


name: positive regulation of DNA ligase activity

description: Any process that activates or increases the frequency, rate or extent of DNA ligase activity.


name: K1C15_HUMAN Keratin, type I cytoskeletal 15 (sprot)

description: A keratin, type I cytoskeletal 15 that is encoded in the genome of human.


name: K2C4_HUMAN Keratin, type II cytoskeletal 4 (sprot)

description: A keratin, type II cytoskeletal 4 that is encoded in the genome of human.


name: AMD_HUMAN Peptidyl-glycine alpha-amidating monooxygenase (sprot)

description: A peptidyl-glycine alpha-amidating monooxygenase that is encoded in the genome of human.


peptidylglycine monooxygenase activity

description: Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O.


peptidylamidoglycolate lyase activity

description: Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate.


peptide amidation

description: The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions.


name: fatty acid primary amide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a fatty acid primary amide.


CADH2_HUMAN Cadherin-2 (sprot)

A cadherin-2 that is encoded in the genome of human.


name: regulation of oligodendrocyte progenitor proliferation

description: Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation.


mesenchymal cell migration

description: The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism.


name: neuroligin clustering involved in postsynaptic membrane assembly

description: The receptor clustering process involved in assembly of the postsynaptic membrane in which neuroligins are localized to distinct domains in the cell membrane. Neuroligins are neuronal cell surface proteins on the postsynaptic membrane that mediate synapse formation between neurons.


name: regulation of postsynaptic density protein 95 clustering

description: Any process that modulates the frequency, rate or extent of postsynaptic density protein 95 clustering.


name: positive regulation of synaptic vesicle clustering

description: Any process that activates or increases the frequency, rate or extent of synaptic vesicle clustering.


TSN8_HUMAN Tetraspanin-8 (sprot)

A tetraspanin-8 that is encoded in the genome of human.


name: GNAZ_HUMAN Guanine nucleotide-binding protein G(z) subunit alpha (sprot)

description: A guanine nucleotide-binding protein G(z) subunit alpha that is encoded in the genome of human.


adenylate cyclase inhibitor activity

description: Binds to and decreases the activity of adenylate cyclase.


name: G protein-coupled serotonin receptor binding

description: Binding to a metabotropic serotonin receptor.


name: GNAT2_HUMAN Guanine nucleotide-binding protein G(t) subunit alpha-2 (sprot)

description: A guanine nucleotide-binding protein G(t) subunit alpha-2 that is encoded in the genome of human.


homeostasis of number of retina cells

description: Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the retina.


L-glutamate import

description: The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle.


name: cone retinal bipolar cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a cone retinal bipolar cell.


name: C11B2_HUMAN Cytochrome P450 11B2, mitochondrial (sprot)

description: A cytochrome P450 11B that is a translation product of the CYP11B2 gene in human.


name: regulation of blood volume by renal aldosterone

description: The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume.


name: ML12A_HUMAN Myosin regulatory light chain 12A (sprot)

description: A myosin regulatory light chain MRLC3 that is encoded in the genome of human.


name: DCHS_HUMAN Histidine decarboxylase (sprot)

description: A histidine decarboxylase that is encoded in the genome of human.


histidine decarboxylase activity

description: Catalysis of the reaction: L-histidine = histamine + CO2.


histamine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.


L-histidine metabolic process

description: The chemical reactions and pathways involving L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.


name: PLCG1_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (sprot)

description: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 that is encoded in the genome of human.


neurotrophin TRKA receptor binding

description: Binding to a neurotrophin TRKA receptor.


name: calcium-dependent phospholipase C activity

description: Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+.


name: UD16_HUMAN UDP-glucuronosyltransferase 1-6 (sprot)

description: A UDP-glucuronosyltransferase 1-6 that is encoded in the genome of human.


name: EPOR_HUMAN Erythropoietin receptor (sprot)

description: An erythropoietin receptor that is encoded in the genome of human.


erythropoietin receptor activity

description: Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: TNNI1_HUMAN Troponin I, slow skeletal muscle (sprot)

description: A troponin I, slow skeletal muscle that is encoded in the genome of human.


name: LFA3_HUMAN Lymphocyte function-associated antigen 3 (sprot)

description: A lymphocyte function-associated antigen 3 that is encoded in the genome of human.


name: VCAM1_HUMAN Vascular cell adhesion protein 1 (sprot)

description: A vascular cell adhesion protein 1 that is encoded in the genome of human.


cell adhesion mediator activity

description: The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell.


cardiac neuron differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart.


name: alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex

description: A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1.


NUCL_HUMAN Nucleolin (sprot)

A nucleolin that is encoded in the genome of human.


DNA topoisomerase binding

description: Binding to a DNA topoisomerase.


name: positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

description: Any process that activates or increases the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I.


macropinosome membrane

description: The lipid bilayer surrounding a macropinosome.


HXK1_HUMAN Hexokinase-1 (sprot)

A hexokinase-1 that is encoded in the genome of human.


glucokinase activity

description: Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.


hexokinase activity

description: Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.


fructokinase activity

description: Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate.


mannokinase activity

description: Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate.


glucosamine kinase activity

description: Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H+.


name: maintenance of protein location in mitochondrion

description: Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere.


name: RPB3_HUMAN DNA-directed RNA polymerase II subunit RPB3 (sprot)

description: A DNA-directed RNA polymerase II subunit RPB3 that is encoded in the genome of human.


name: RPAB1_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC1 (sprot)

description: A DNA-directed RNA polymerases I, II, and III subunit RPABC1 that is encoded in the genome of human.


name: CD53_HUMAN Leukocyte surface antigen CD53 (sprot)

description: A CD53 molecule that is encoded in the genome of human.


name: NDUV2_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (sprot)

description: An NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial that is encoded in the genome of human.


name: ELK1_HUMAN ETS domain-containing protein Elk-1 (sprot)

description: An ETS domain-containing protein Elk-1 that is encoded in the genome of human.


name: TNNI3_HUMAN Troponin I, cardiac muscle (sprot)

description: A troponin I, cardiac muscle that is encoded in the genome of human.


troponin C binding

description: Binding to troponin C, the calcium-binding subunit of the troponin complex.


troponin T binding

description: Binding to troponin T, the tropomyosin-binding subunit of the troponin complex.


name: regulation of systemic arterial blood pressure by ischemic conditions

description: The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system.


cardiac Troponin complex

description: A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction.


name: TNR1A_HUMAN Tumor necrosis factor receptor superfamily member 1A (sprot)

description: A tumor necrosis factor receptor superfamily member 1A that is encoded in the genome of human.


tumor necrosis factor receptor activity

description: Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.


pulmonary valve development

description: The progression of the pulmonary valve over time, from its formation to the mature structure.


name: negative regulation of extracellular matrix constituent secretion

description: Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.


name: positive regulation of amide metabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides.


name: positive regulation of lipid metabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids.