name: ASCL1_HUMAN Achaete-scute homolog 1 (sprot)

description: An achaete-scute homolog 1 that is encoded in the genome of human.


noradrenergic neuron development

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.


noradrenergic neuron fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron.


neuroblast fate determination

description: The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.


subpallium neuron fate commitment

description: The process in which in the subpallium, the developmental fate of a cell becomes restricted such that it will develop into a neuron. The subpallium is the base region of the telencephalon.


name: regulation of timing of subpallium neuron differentiation

description: The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon.


name: ventral spinal cord interneuron fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses.


name: lung neuroendocrine cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium.


name: stomach neuroendocrine cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium.


name: carotid body glomus cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia.


adrenal chromaffin cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles.


cellular response to magnetism

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus.


DYN2_HUMAN Dynamin-2 (sprot)

A dynamin-2 that is encoded in the genome of human.


actin filament bundle organization

description: A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.


vesicle scission

description: The membrane scission process that is the final step in the formation of a vesicle, leading to separation from its parent membrane. Vesicle scission involves the constriction of a neck-forming protein complex, consisting e.g. of dynamin, around the budded membrane, leading to vesicle closure during its separation from the parent membrane.


name: MAP2_HUMAN Methionine aminopeptidase 2 (sprot)

description: A methionine aminopeptidase 2 that is encoded in the genome of human.


name: initiator methionyl aminopeptidase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the release of N-terminal initiator methionine from peptides.


name: N-terminal protein amino acid modification

description: The alteration of the N-terminal amino acid residue in a protein.


name: AP4A_HUMAN Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] (sprot)

description: A bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] that is encoded in the genome of human.


description: Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP + 2 H+.


name: TNF10_HUMAN Tumor necrosis factor ligand superfamily member 10 (sprot)

description: A tumor necrosis factor ligand superfamily member 10 that is encoded in the genome of human.


TUB_HUMAN Tubby protein homolog (sprot)

A tubby protein that is encoded in the genome of human.


name: receptor localization to non-motile cilium

description: A process in which a receptor is transported to, or maintained in, a location within a non-motile cilium.


name: CDK7_HUMAN Cyclin-dependent kinase 7 (sprot)

description: A cyclin-dependent kinase 7 that is encoded in the genome of human.


transcription factor TFIIK complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7.


TOB1_HUMAN Protein Tob1 (sprot)

A protein Tob1 that is encoded in the genome of human.


name: negative regulation of nuclear-transcribed mRNA poly(A) tail shortening

description: Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.


name: regulation of SMAD protein signal transduction

description: Any process that modulates the rate, frequency or extent of SMAD protein signal transduction.


name: BPL1_HUMAN Biotin--protein ligase (sprot)

description: A biotin--protein ligase that is encoded in the genome of human.


description: Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)).


description: Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase).


name: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity

description: Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming)).


biotin-protein ligase activity

description: Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein.


name: KNTC1_HUMAN Kinetochore-associated protein 1 (sprot)

description: A kinetochore-associated protein 1 that is encoded in the genome of human.


name: RASF2_HUMAN Ras association domain-containing protein 2 (sprot)

description: A Ras association domain-containing protein 2 that is encoded in the genome of human.


name: CDK9_HUMAN Cyclin-dependent kinase 9 (sprot)

description: A cyclin-dependent kinase 9 that is encoded in the genome of human.


name: positive regulation of protein localization to chromatin

description: Any process that activates or increases the frequency, rate or extent of protein localization to chromatin.


name: LRBA_HUMAN Lipopolysaccharide-responsive and beige-like anchor protein (sprot)

description: A lipopolysaccharide-responsive and beige-like anchor protein that is encoded in the genome of human.


name: R144A_HUMAN E3 ubiquitin-protein ligase RNF144A (sprot)

description: An E3 ubiquitin-protein ligase RNF144A that is encoded in the genome of human.


name: BCAM_HUMAN Basal cell adhesion molecule (sprot)

description: A basal cell adhesion molecule that is encoded in the genome of human.


name: PPT1_HUMAN Palmitoyl-protein thioesterase 1 (sprot)

description: A palmitoyl-protein thioesterase 1 that is encoded in the genome of human.


name: negative regulation of toll-like receptor 9 signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway.


name: RL14_HUMAN Large ribosomal subunit protein eL14 (sprot)

description: A large ribosomal subunit protein eL14 that is encoded in the genome of human.


name: TCPQ_HUMAN T-complex protein 1 subunit theta (sprot)

description: A T-complex protein 1 subunit theta that is encoded in the genome of human.


name: TCPD_HUMAN T-complex protein 1 subunit delta (sprot)

description: A T-complex protein 1 subunit delta that is encoded in the genome of human.


name: AT1A2_HUMAN Sodium/potassium-transporting ATPase subunit alpha-2 (sprot)

description: A sodium/potassium-transporting ATPase subunit alpha-2 that is encoded in the genome of human.


olfactory cortex development

description: The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors.


name: negative regulation of calcium ion transmembrane transport

description: Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport.


name: negative regulation of calcium:sodium antiporter activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of calcium:sodium antiporter activity.


ANX11_HUMAN Annexin A11 (sprot)

An annexin A11 that is encoded in the genome of human.


name: PAPOA_HUMAN Poly(A) polymerase alpha (sprot)

description: A poly(A) polymerase alpha that is encoded in the genome of human.


poly(A) RNA polymerase activity

description: Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.


name: FXR1_HUMAN RNA-binding protein FXR1 (sprot)

description: An RNA-binding protein FXR1 that is encoded in the genome of human.


nuclear pore localization

description: Any process in which nuclear pores are transported to, or maintained in, a specific location.


name: negative regulation of mRNA catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process.


name: FXR2_HUMAN RNA-binding protein FXR2 (sprot)

description: An RNA-binding protein FXR2 that is encoded in the genome of human.


GRAM_HUMAN Granzyme M (sprot)

A granzyme M that is encoded in the genome of human.


name: RAB5C_HUMAN Ras-related protein Rab-5C (sprot)

description: A Ras-related protein Rab-5C that is encoded in the genome of human.


plasma membrane to endosome transport

description: Transport of a vesicle from the plasma membrane to the endosome.


name: RAB7A_HUMAN Ras-related protein Rab-7a (sprot)

description: A Ras-related protein Rab-7a that is encoded in the genome of human.


name: epidermal growth factor catabolic process

description: The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor.


establishment of vesicle localization

description: The directed movement of a vesicle to a specific location.


lipophagy

description: The selective degradation of lipid droplets by macroautophagy.


phagosome maturation

description: A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.


phagosome acidification

description: Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion.


name: endosome to plasma membrane protein transport

description: The directed movement of proteins from the endosome to the plasma membrane in transport vesicles.


name: RAB9A_HUMAN Ras-related protein Rab-9A (sprot)

description: A Ras-related protein Rab-9A that is encoded in the genome of human.


name: negative regulation by host of symbiont catalytic activity

description: Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.


name: RAB13_HUMAN Ras-related protein Rab-13 (sprot)

description: A Ras-related protein Rab-13 that is encoded in the genome of human.


name: trans-Golgi network to recycling endosome transport

description: The directed movement of substances, in membrane-bounded vesicles, from the trans-Golgi network to the recycling endosomes.


name: protein localization to cell leading edge

description: A process in which a protein is transported to, or maintained in, a location within a cell leading edge.


name: RAB28_HUMAN Ras-related protein Rab-28 (sprot)

description: A Ras-related protein Rab-28 that is encoded in the genome of human.


name: RB27A_HUMAN Ras-related protein Rab-27A (sprot)

description: A Ras-related protein Rab-27A that is encoded in the genome of human.


melanosome localization

description: Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell.


multivesicular body organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.


cytotoxic T cell degranulation

description: The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell.


name: positive regulation of constitutive secretory pathway

description: Any process that activates or increases the frequency, rate or extent of constitutive secretory pathway.


exosomal secretion

description: The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.


name: PDE6C_HUMAN Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (sprot)

description: A cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' that is encoded in the genome of human.


FABP6_HUMAN Gastrotropin (sprot)

A gastrotropin that is encoded in the genome of human.


name: ATP4B_HUMAN Potassium-transporting ATPase subunit beta (sprot)

description: A potassium-transporting ATPase subunit beta that is encoded in the genome of human.


name: SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta (sprot)

description: An amiloride-sensitive sodium channel subunit beta that is encoded in the genome of human.


name: SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma (sprot)

description: An amiloride-sensitive sodium channel subunit gamma that is encoded in the genome of human.


name: SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta (sprot)

description: An amiloride-sensitive sodium channel subunit delta that is encoded in the genome of human.


name: PLCD1_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (sprot)

description: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 that is encoded in the genome of human.


name: DAP1_HUMAN Death-associated protein 1 (sprot)

description: A death-associated protein 1 that is encoded in the genome of human.


death domain binding

description: Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB.


name: RT29_HUMAN Small ribosomal subunit protein mS29 (sprot)

description: A small ribosomal subunit protein mS29 that is encoded in the genome of human.


name: RORG_HUMAN Nuclear receptor ROR-gamma (sprot)

description: A nuclear receptor ROR-gamma that is encoded in the genome of human.


name: BLK_HUMAN Tyrosine-protein kinase Blk (sprot)

description: A tyrosine-protein kinase BLK that is encoded in the genome of human.


name: DUS3_HUMAN Dual specificity protein phosphatase 3 (sprot)

description: A dual specificity protein phosphatase 3 that is encoded in the genome of human.


MAP kinase phosphatase activity

description: Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate.


INSL3_HUMAN Insulin-like 3 (sprot)

An insulin-like 3 that is encoded in the genome of human.


name: ZNF80_HUMAN Zinc finger protein 80 (sprot)

description: A zinc finger protein 80 that is encoded in the genome of human.


name: ZNF81_HUMAN Zinc finger protein 81 (sprot)

description: A zinc finger protein 81 that is encoded in the genome of human.


name: MMP15_HUMAN Matrix metalloproteinase-15 (sprot)

description: A matrix metalloproteinase-15 that is encoded in the genome of human.


name: MMP16_HUMAN Matrix metalloproteinase-16 (sprot)

description: A matrix metalloproteinase-16 that is encoded in the genome of human.


name: NOVA1_HUMAN RNA-binding protein Nova-1 (sprot)

description: An RNA-binding protein Nova-1 that is encoded in the genome of human.


name: ZNF83_HUMAN Zinc finger protein 83 (sprot)

description: A zinc finger protein 83 that is encoded in the genome of human.


name: ZNF84_HUMAN Zinc finger protein 84 (sprot)

description: A zinc finger protein 84 that is encoded in the genome of human.


name: DNA2_HUMAN DNA replication ATP-dependent helicase/nuclease DNA2 (sprot)

description: A DNA replication ATP-dependent helicase/nuclease DNA2 that is encoded in the genome of human.


gamma DNA polymerase complex

description: A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA.


name: DNA replication, Okazaki fragment processing

description: The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand.


name: SMCA2_HUMAN Probable global transcription activator SNF2L2 (sprot)

description: A probable global transcription activator SNF2L2 that is encoded in the genome of human.


name: SMCA4_HUMAN Transcription activator BRG1 (sprot)

description: A transcription activator BRG1 that is encoded in the genome of human.


name: positive regulation of glucose mediated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of glucose mediated signaling pathway.


name: IDH3G_HUMAN Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (sprot)

description: An isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial that is encoded in the genome of human.


GALK1_HUMAN Galactokinase (sprot)

A galactokinase that is encoded in the genome of human.


galactokinase activity

description: Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H+.


galactitol metabolic process

description: The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose.


glycolytic process from galactose

description: The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP.


name: SSRD_HUMAN Translocon-associated protein subunit delta (sprot)

description: A translocon-associated protein subunit delta that is encoded in the genome of human.


Sec61 translocon complex

description: A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events.


name: BAP31_HUMAN B-cell receptor-associated protein 31 (sprot)

description: A B-cell receptor-associated protein 31 that is encoded in the genome of human.


name: positive regulation of retrograde protein transport, ER to cytosol

description: Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol.


P2RX1_HUMAN P2X purinoceptor 1 (sprot)

A P2X purinoceptor 1 that is encoded in the genome of human.


suramin binding

description: Binding to suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms.


name: TPMT_HUMAN Thiopurine S-methyltransferase (sprot)

description: A thiopurine S-methyltransferase that is encoded in the genome of human.


thiopurine S-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.


P2RY4_HUMAN P2Y purinoceptor 4 (sprot)

A P2Y purinoceptor 4 that is encoded in the genome of human.


G protein-coupled UTP receptor activity

description: Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP.


name: BRCA2_HUMAN Breast cancer type 2 susceptibility protein (sprot)

description: A breast cancer type 2 susceptibility protein that is encoded in the genome of human.


name: mitotic recombination-dependent replication fork processing

description: Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart.


BRCA2-MAGE-D1 complex

description: A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth.


CP2J2_HUMAN Cytochrome P450 2J2 (sprot)

A cytochrome P450 2J2 that is encoded in the genome of human.


name: hydroperoxy icosatetraenoate isomerase activity

description: A hydroperoxy icosatetraenoate = a hydroxy epoxy icosatrienoate.


name: arachidonic acid 5,6-epoxygenase activity

description: Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-5,6-epoxyeicosatrienoic acid.


name: RENBP_HUMAN N-acylglucosamine 2-epimerase (sprot)

description: An N-acylglucosamine 2-epimerase that is encoded in the genome of human.


N-acylglucosamine 2-epimerase activity

description: Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine.


N-acetylneuraminate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid.


name: MECP2_HUMAN Methyl-CpG-binding protein 2 (sprot)

description: A methyl-CpG-binding protein 2 that is encoded in the genome of human.


siRNA binding

description: Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.


unmethylated CpG binding

description: Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters.


cardiolipin metabolic process

description: The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.


catecholamine secretion

description: The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.


name: cellular response to isoquinoline alkaloid

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids.


name: negative regulation of locomotion involved in locomotory behavior

description: Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.


trans-synaptic signaling by BDNF

description: Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft.


name: positive regulation of retrograde dense core granule transport

description: Any process that activates or increases the frequency, rate or extent of retrograde dense core granule transport.


name: negative regulation of respiratory gaseous exchange

description: Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange.


HCFC1_HUMAN Host cell factor 1 (sprot)

A host cell factor 1 that is encoded in the genome of human.


name: IRAK1_HUMAN Interleukin-1 receptor-associated kinase 1 (sprot)

description: An interleukin-1 receptor-associated kinase 1 that is encoded in the genome of human.


toll-like receptor 9 signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 9.


CAV2_HUMAN Caveolin-2 (sprot)

A caveolin-2 that is encoded in the genome of human.


name: negative regulation of skeletal muscle cell proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation.


name: caveolar macromolecular signaling complex

description: A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3).


name: AL3A2_HUMAN Aldehyde dehydrogenase family 3 member A2 (sprot)

description: An aldehyde dehydrogenase family 3 member A2 that is encoded in the genome of human.


long-chain-alcohol oxidase activity

description: Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O.


description: Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons.


description: Catalysis of the reaction: a medium-chain aldehyde + NAD+ = a medium-chain carboxylate + NADH + H+. Medium-chain aldehydes have a chain length of between 8 and 12 carbons.


phytol metabolic process

description: The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol.


hexadecanal metabolic process

description: The chemical reactions and pathways involving hexadecanal, the C16 straight chain aldehyde.


name: SSDH_HUMAN Succinate-semialdehyde dehydrogenase, mitochondrial (sprot)

description: A succinate-semialdehyde dehydrogenase, mitochondrial that is encoded in the genome of human.


name: succinate-semialdehyde dehydrogenase (NAD+) activity

description: Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+.


name: gamma-aminobutyric acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.


GPC3_HUMAN Glypican-3 (sprot)

A glypican-3 that is encoded in the genome of human.


peptidyl-dipeptidase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain.


body morphogenesis

description: The process in which the anatomical structures of the soma are generated and organized.


name: cell proliferation involved in kidney development

description: The multiplication or reproduction of cells, resulting in the expansion of the population in the kidney.


mesonephric duct morphogenesis

description: The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros.


name: cell proliferation involved in metanephros development

description: The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros.


name: regulation of non-canonical Wnt signaling pathway

description: Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway.


name: DHB4_HUMAN Peroxisomal multifunctional enzyme type 2 (sprot)

description: A peroxisomal multifunctional enzyme type 2 that is encoded in the genome of human.


description: Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O.


name: (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity

description: Catalysis of the reaction: 3R-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.


name: very long-chain fatty-acyl-CoA metabolic process

description: The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a very long-chain fatty-acyl group. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.


name: medium-chain fatty-acyl-CoA metabolic process

description: The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.


name: PSMD7_HUMAN 26S proteasome non-ATPase regulatory subunit 7 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 7 that is encoded in the genome of human.


name: UB2D1_HUMAN Ubiquitin-conjugating enzyme E2 D1 (sprot)

description: A ubiquitin-conjugating enzyme E2 D1 that is encoded in the genome of human.


name: positive regulation of protein polyubiquitination

description: Any process that activates or increases the frequency, rate or extent of protein polyubiquitination.


CCL11_HUMAN Eotaxin (sprot)

An eotaxin that is encoded in the genome of human.


response to interleukin-4

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.


name: GPM6A_HUMAN Neuronal membrane glycoprotein M6-a (sprot)

description: A neuronal membrane glycoprotein M6-a that is encoded in the genome of human.


name: CCR3_HUMAN C-C chemokine receptor type 3 (sprot)

description: A C-C chemokine receptor type 3 that is encoded in the genome of human.


name: CCR4_HUMAN C-C chemokine receptor type 4 (sprot)

description: A C-C chemokine receptor type 4 that is encoded in the genome of human.


tolerance induction

description: A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it.


name: CCR5_HUMAN C-C chemokine receptor type 5 (sprot)

description: A C-C chemokine receptor type 5 that is encoded in the genome of human.


name: CCR6_HUMAN C-C chemokine receptor type 6 (sprot)

description: A C-C chemokine receptor type 6 that is encoded in the genome of human.


isotype switching to IgA isotypes

description: The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus.


name: positive regulation of flagellated sperm motility involved in capacitation

description: The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence.


DN3 thymocyte differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a DN3 thymocyte. A DN3 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25+.


name: CCR8_HUMAN C-C chemokine receptor type 8 (sprot)

description: A C-C chemokine receptor type 8 that is encoded in the genome of human.


name: CCR9_HUMAN C-C chemokine receptor type 9 (sprot)

description: A C-C chemokine receptor type 9 that is encoded in the genome of human.


name: SUOX_HUMAN Sulfite oxidase, mitochondrial (sprot)

description: A sulfite oxidase, mitochondrial that is encoded in the genome of human.


molybdenum ion binding

description: Binding to a molybdenum ion (Mo).


name: SPHM_HUMAN N-sulphoglucosamine sulphohydrolase (sprot)

description: An N-sulphoglucosamine sulphohydrolase that is encoded in the genome of human.


description: Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate.


ARSD_HUMAN Arylsulfatase D (sprot)

An arylsulfatase D that is encoded in the genome of human.


ARSL_HUMAN Arylsulfatase L (sprot)

An arylsulfatase L that is encoded in the genome of human.


name: STA5B_HUMAN Signal transducer and activator of transcription 5B (sprot)

description: A signal transducer and activator of transcription 5b that is encoded in the genome of human.


name: development of secondary female sexual characteristics

description: The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion.


response to interleukin-2

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus.


response to interleukin-15

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus.


name: APLP1_HUMAN Amyloid beta precursor like protein 1 (sprot)

description: An amyloid beta precursor like protein 1 that is encoded in the genome of human.


alpha-2B adrenergic receptor binding

description: Binding to an alpha-2B adrenergic receptor.


name: cellular response to norepinephrine stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.


name: UBP11_HUMAN Ubiquitin carboxyl-terminal hydrolase 11 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 11 that is encoded in the genome of human.


name: ZN157_HUMAN Zinc finger protein 157 (sprot)

description: A zinc finger protein 157 that is encoded in the genome of human.


name: KCNQ1_HUMAN Potassium voltage-gated channel subfamily KQT member 1 (sprot)

description: A voltage-gated potassium channel subunit KCNQ1 that is encoded in the genome of human.


gastrin-induced gastric acid secretion

description: The regulated release of gastric acid induced by the interaction of gastrin with its receptor.


corticosterone secretion

description: The regulated release of corticosterone into the circulatory system. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.


stomach development

description: The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ.


basolateral part of cell

description: The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells.


name: CLCN2_HUMAN Chloride channel protein 2 (sprot)

description: A chloride channel protein 2 that is encoded in the genome of human.


name: regulation of aldosterone biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.


name: CLCN3_HUMAN H(+)/Cl(-) exchange transporter 3 (sprot)

description: An H(+)/Cl(-) exchange transporter 3 that is encoded in the genome of human.


name: volume-sensitive chloride channel activity

description: Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell.


negative regulation of cell volume

description: Any process that decreases cell volume.


name: CLCN4_HUMAN H(+)/Cl(-) exchange transporter 4 (sprot)

description: An H(+)/Cl(-) exchange transporter 4 that is encoded in the genome of human.


name: CLCN5_HUMAN H(+)/Cl(-) exchange transporter 5 (sprot)

description: An H(+)/Cl(-) exchange transporter 5 that is encoded in the genome of human.


name: CLCN6_HUMAN H(+)/Cl(-) exchange transporter 6 (sprot)

description: A chloride channel protein 6 that is encoded in the genome of human.


name: CLCN7_HUMAN H(+)/Cl(-) exchange transporter 7 (sprot)

description: An H(+)/Cl(-) exchange transporter 7 that is encoded in the genome of human.


name: CLCKA_HUMAN Chloride channel protein ClC-Ka (sprot)

description: A chloride channel protein ClC-Ka that is encoded in the genome of human.


name: CLCKB_HUMAN Chloride channel protein ClC-Kb (sprot)

description: A chloride channel protein ClC-Kb that is encoded in the genome of human.


PLXA3_HUMAN Plexin-A3 (sprot)

A plexin-A3 that is encoded in the genome of human.


neuron projection guidance

description: The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.


olfactory nerve formation

description: The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.


name: DYLT3_HUMAN Dynein light chain Tctex-type 3 (sprot)

description: A dynein light chain Tctex-type 3 that is encoded in the genome of human.


mitotic spindle astral microtubule

description: Any of the mitotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.


name: VAMP7_HUMAN Vesicle-associated membrane protein 7 (sprot)

description: A vesicle-associated membrane protein 7 that is encoded in the genome of human.


name: GP143_HUMAN G-protein coupled receptor 143 (sprot)

description: A G-protein coupled receptor 143 that is encoded in the genome of human.


L-DOPA receptor activity

description: Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine.


L-DOPA binding

description: Binding to L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid.


L-tyrosine binding

description: Binding to L-tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid.


regulation of melanosome transport

description: Any process that modulates the frequency, rate or extent of melanosome transport.


name: XK_HUMAN Endoplasmic reticulum membrane adapter protein XK (sprot)

description: An endoplasmic reticulum membrane adapter protein XK that is encoded in the genome of human.


name: KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 (sprot)

description: A ribosomal protein S6 kinase alpha-3 that is encoded in the genome of human.


name: BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX (sprot)

description: A cytoplasmic tyrosine-protein kinase BMX that is encoded in the genome of human.


name: ZNF41_HUMAN Zinc finger protein 41 (sprot)

description: A zinc finger protein 41 that is encoded in the genome of human.


name: ZN75D_HUMAN Zinc finger protein 75D (sprot)

description: A zinc finger protein 75D that is encoded in the genome of human.


name: AFF2_HUMAN AF4/FMR2 family member 2 (sprot)

description: An AF4/FMR2 family member 2 that is encoded in the genome of human.


G-quadruplex RNA binding

description: Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad.


name: PRKX_HUMAN cAMP-dependent protein kinase catalytic subunit PRKX (sprot)

description: A serine/threonine-protein kinase PRKX that is encoded in the genome of human.


epithelial tube morphogenesis

description: The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.


name: regulation of epithelial cell differentiation involved in kidney development

description: Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development.


name: AFF1_HUMAN AF4/FMR2 family member 1 (sprot)

description: An AF4/FMR2 family member 1 that is encoded in the genome of human.


name: AFF3_HUMAN AF4/FMR2 family member 3 (sprot)

description: An AF4/FMR2 family member 3 that is encoded in the genome of human.


name: ADCY7_HUMAN Adenylate cyclase type 7 (sprot)

description: An adenylate cyclase type 7 that is encoded in the genome of human.


name: GUC2F_HUMAN Retinal guanylyl cyclase 2 (sprot)

description: A retinal guanylyl cyclase 2 that is encoded in the genome of human.


name: NR0B1_HUMAN Nuclear receptor subfamily 0 group B member 1 (sprot)

description: A nuclear receptor subfamily 0 group B member 1 that is encoded in the genome of human.


DNA hairpin binding

description: Binding to a DNA region containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences.


name: TKTL1_HUMAN Transketolase-like protein 1 (sprot)

description: A transketolase-like protein 1 that is encoded in the genome of human.


name: AK1D1_HUMAN Aldo-keto reductase family 1 member D1 (sprot)

description: An aldo-keto reductase family 1 member D1 that is encoded in the genome of human.


C21-steroid hormone metabolic process

description: The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.


bile acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.


name: HDGF_HUMAN Hepatoma-derived growth factor (sprot)

description: A hepatoma-derived growth factor that is encoded in the genome of human.


name: CDR1_HUMAN Cerebellar degeneration-related antigen 1 (sprot)

description: A cerebellar degeneration-related antigen 1 that is encoded in the genome of human.


name: TDGF3_HUMAN Putative protein CRIPTO3 (sprot)

description: A putative protein CRIPTO3 that is encoded in the genome of human.


CASP5_HUMAN Caspase-5 (sprot)

A caspase-5 that is encoded in the genome of human.


LUM_HUMAN Lumican (sprot)

A lumican that is encoded in the genome of human.


fibrillar collagen trimer

description: Any triple helical collagen trimer that forms fibrils.


PRELP_HUMAN Prolargin (sprot)

A prolargin that is encoded in the genome of human.


CNN1_HUMAN Calponin-1 (sprot)

A calponin-1 that is encoded in the genome of human.


CCNH_HUMAN Cyclin-H (sprot)

A cyclin-H that is encoded in the genome of human.


name: MAT1_HUMAN CDK-activating kinase assembly factor MAT1 (sprot)

description: A CDK-activating kinase assembly factor MAT1 that is encoded in the genome of human.


name: NEK2_HUMAN Serine/threonine-protein kinase Nek2 (sprot)

description: A serine/threonine-protein kinase Nek2 that is encoded in the genome of human.


centrosome separation

description: The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.


name: negative regulation of centriole-centriole cohesion

description: Any process that stops, prevents or reduces the frequency, rate or extent of centriole-centriole cohesion.


name: NEK3_HUMAN Serine/threonine-protein kinase Nek3 (sprot)

description: A serine/threonine-protein kinase Nek3 that is encoded in the genome of human.


name: NEK4_HUMAN Serine/threonine-protein kinase Nek4 (sprot)

description: A serine/threonine-protein kinase Nek4 that is encoded in the genome of human.


ciliary plasm

description: All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.


CCNG1_HUMAN Cyclin-G1 (sprot)

A cyclin-G1 that is encoded in the genome of human.


name: UB2E1_HUMAN Ubiquitin-conjugating enzyme E2 E1 (sprot)

description: A ubiquitin-conjugating enzyme E2 E1 that is encoded in the genome of human.


name: NDUA8_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 that is encoded in the genome of human.


name: ROA3_HUMAN Heterogeneous nuclear ribonucleoprotein A3 (sprot)

description: A heterogeneous nuclear ribonucleoprotein A3 that is encoded in the genome of human.


name: FUT6_HUMAN 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (sprot)

description: A 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 that is encoded in the genome of human.


N-glycan fucosylation

description: The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains.


MYOM1_HUMAN Myomesin-1 (sprot)

A myomesin-1 that is encoded in the genome of human.


extraocular skeletal muscle development

description: The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.


striated muscle myosin thick filament

description: Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils.


name: RND2_HUMAN Rho-related GTP-binding protein RhoN (sprot)

description: A Rho-related GTP-binding protein RhoN that is encoded in the genome of human.


name: 6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating (sprot)

description: A 6-phosphogluconate dehydrogenase, decarboxylating that is encoded in the genome of human.


name: phosphogluconate dehydrogenase (decarboxylating) activity

description: Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+.


name: HNRPM_HUMAN Heterogeneous nuclear ribonucleoprotein M (sprot)

description: A heterogeneous nuclear ribonucleoprotein M that is encoded in the genome of human.


name: IMA1_HUMAN Importin subunit alpha-1 (sprot)

description: An importin subunit alpha-1 that is encoded in the genome of human.


name: IMA5_HUMAN Importin subunit alpha-5 (sprot)

description: An importin subunit alpha-5 that is encoded in the genome of human.


name: satellite cell activation involved in skeletal muscle regeneration

description: The process that initiates skeletal muscle satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.


name: NCBP2_HUMAN Nuclear cap-binding protein subunit 2 (sprot)

description: A nuclear cap-binding protein subunit 2 that is encoded in the genome of human.


snRNA export from nucleus

description: The directed movement of snRNA from the nucleus to the cytoplasm.


mRNA metabolic process

description: The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.


name: positive regulation of mRNA 3'-end processing

description: Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing.


name: regulatory ncRNA-mediated post-transcriptional gene silencing

description: A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation.


name: positive regulation of RNA export from nucleus

description: Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm.


nuclear cap binding complex

description: A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.


RNA cap binding complex

description: A protein complex that binds to an RNA cap structure to mediate RNA processing and/or translation initiation.


name: GDS1_HUMAN Rap1 GTPase-GDP dissociation stimulator 1 (sprot)

description: A Rap1 GTPase-GDP dissociation stimulator 1 that is encoded in the genome of human.


myosin filament assembly

description: The aggregation, arrangement and bonding together of a filament composed of myosin molecules.


regulation of ERK5 cascade

description: Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.


CAAX-box protein maturation

description: A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase.


name: angiotensin-activated signaling pathway involved in heart process

description: An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart.


name: regulation of matrix metallopeptidase secretion

description: Any process that modulates the frequency, rate or extent of matrix metallopeptidase secretion.


name: JAK3_HUMAN Tyrosine-protein kinase JAK3 (sprot)

description: A tyrosine-protein kinase JAK3 that is encoded in the genome of human.


name: negative regulation of dendritic cell cytokine production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production.


negative regulation of FasL production

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.


response to interleukin-9

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus.


name: DGKE_HUMAN Diacylglycerol kinase epsilon (sprot)

description: A diacylglycerol kinase epsilon that is encoded in the genome of human.


name: RPAB3_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC3 (sprot)

description: A DNA-directed RNA polymerases I, II, and III subunit RPABC3 that is encoded in the genome of human.


name: RPB11_HUMAN DNA-directed RNA polymerase II subunit RPB11-a (sprot)

description: A DNA-directed RNA polymerase II subunit RPB11-a that is encoded in the genome of human.


LRR domain binding

description: Binding to a LRR domain (leucine rich repeats) of a protein.


name: MP2K6_HUMAN Dual specificity mitogen-activated protein kinase kinase 6 (sprot)

description: A dual specificity mitogen-activated protein kinase kinase 6 that is encoded in the genome of human.


name: GDIR1_HUMAN Rho GDP-dissociation inhibitor 1 (sprot)

description: A Rho GDP-dissociation inhibitor 1 that is encoded in the genome of human.


name: GDIR2_HUMAN Rho GDP-dissociation inhibitor 2 (sprot)

description: A Rho GDP-dissociation inhibitor 2 that is encoded in the genome of human.


Rho GDP-dissociation inhibitor activity

description: Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding.


cellular response to redox state

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important.


name: CTR2_HUMAN Cationic amino acid transporter 2 (sprot)

description: A cationic amino acid transporter 2 that is encoded in the genome of human.


name: AGFG1_HUMAN Arf-GAP domain and FG repeat-containing protein 1 (sprot)

description: An Arf-GAP domain and FG repeat-containing protein 1 that is encoded in the genome of human.


name: HNRPF_HUMAN Heterogeneous nuclear ribonucleoprotein F (sprot)

description: A heterogeneous nuclear ribonucleoprotein F that is encoded in the genome of human.


name: STAT2_HUMAN Signal transducer and activator of transcription 2 (sprot)

description: A signal transducer and activator of transcription 2 that is encoded in the genome of human.


name: TF2AA_HUMAN Transcription initiation factor IIA subunit 1 (sprot)

description: A transcription initiation factor IIA subunit 1 that is encoded in the genome of human.


name: T2AG_HUMAN Transcription initiation factor IIA subunit 2 (sprot)

description: A transcription initiation factor IIA subunit 2 that is encoded in the genome of human.


name: MSH6_HUMAN DNA mismatch repair protein Msh6 (sprot)

description: A DNA mismatch repair protein Msh6 that is encoded in the genome of human.


meiotic mismatch repair

description: A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis.


name: KIF11_HUMAN Kinesin-like protein KIF11 (sprot)

description: A kinesin-like protein KIF11 that is encoded in the genome of human.


name: VAV2_HUMAN Guanine nucleotide exchange factor VAV2 (sprot)

description: A guanine nucleotide exchange factor VAV2 that is encoded in the genome of human.


name: ZN133_HUMAN Zinc finger protein 133 (sprot)

description: A zinc finger protein 133 that is encoded in the genome of human.


name: ZN136_HUMAN Zinc finger protein 136 (sprot)

description: A zinc finger protein 136 that is encoded in the genome of human.


name: ZN140_HUMAN Zinc finger protein 140 (sprot)

description: A zinc finger protein 140 that is encoded in the genome of human.


name: ZN131_HUMAN Zinc finger protein 131 (sprot)

description: A zinc finger protein 131 that is encoded in the genome of human.


name: ZN132_HUMAN Zinc finger protein 132 (sprot)

description: A zinc finger protein 132 that is encoded in the genome of human.


name: ZN134_HUMAN Zinc finger protein 134 (sprot)

description: A zinc finger protein 134 that is encoded in the genome of human.


name: ZN135_HUMAN Zinc finger protein 135 (sprot)

description: A zinc finger protein 135 that is encoded in the genome of human.


name: ZN137_HUMAN Putative zinc finger protein 137 (sprot)

description: A putative zinc finger protein 137 that is encoded in the genome of human.


name: ZN138_HUMAN Zinc finger protein 138 (sprot)

description: A zinc finger protein 138 that is encoded in the genome of human.


name: ZN142_HUMAN Zinc finger protein 142 (sprot)

description: A zinc finger protein 142 that is encoded in the genome of human.


name: ZN143_HUMAN Zinc finger protein 143 (sprot)

description: A zinc finger protein 143 that is encoded in the genome of human.


name: RBM5_HUMAN RNA-binding protein 5 (sprot)

description: An RNA-binding protein 5 that is encoded in the genome of human.


CHIO_HUMAN Beta-chimaerin (sprot)

A beta-chimaerin that is encoded in the genome of human.


name: RIDA_HUMAN 2-iminobutanoate/2-iminopropanoate deaminase (sprot)

description: A 2-iminobutanoate/2-iminopropanoate deaminase that is encoded in the genome of human.


name: RNA endonuclease activity, producing 3'-phosphomonoesters

description: Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters.


2-iminobutanoate deaminase activity

description: Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+).


2-iminopropanoate deaminase activity

description: Catalysis of the reaction: 2-iminopropanoate + H2O = NH4(+) + pyruvate.


name: L-threonine catabolic process to glycine

description: The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form to form 2-amino-3-oxobutanoate, which is subsequently converted to glycine.


name: organonitrogen compound catabolic process

description: The chemical reactions and pathways resulting in the breakdown of organonitrogen compound.


SPSY_HUMAN Spermine synthase (sprot)

A spermine synthase that is encoded in the genome of human.


spermine synthase activity

description: Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.


spermine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging.


HXK2_HUMAN Hexokinase-2 (sprot)

A hexokinase-2 that is encoded in the genome of human.


name: negative regulation of mitochondrial membrane permeability

description: Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.


HXK3_HUMAN Hexokinase-3 (sprot)

A hexokinase-3 that is encoded in the genome of human.


EFNA3_HUMAN Ephrin-A3 (sprot)

An ephrin-A3 that is encoded in the genome of human.


EFNA4_HUMAN Ephrin-A4 (sprot)

An ephrin-A4 that is encoded in the genome of human.


EFNB2_HUMAN Ephrin-B2 (sprot)

An ephrin-B2 that is encoded in the genome of human.


regulation of chemotaxis

description: Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.


EFNA5_HUMAN Ephrin-A5 (sprot)

An ephrin-A5 that is encoded in the genome of human.


neurotrophin TRKB receptor binding

description: Binding to a neurotrophin TRKB receptor.


neurotrophin TRKC receptor binding

description: Binding to a neurotrophin TRKC receptor.


name: RM12_HUMAN Large ribosomal subunit protein bL12m (sprot)

description: A large ribosomal subunit protein bL12m that is encoded in the genome of human.


STC1_HUMAN Stanniocalcin-1 (sprot)

A stanniocalcin-1 that is encoded in the genome of human.


name: growth plate cartilage axis specification

description: The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth.


name: negative regulation of renal phosphate excretion

description: Any process that stops, prevents or reduces the frequency, rate or extent of renal phosphate excretion.


name: DGKQ_HUMAN Diacylglycerol kinase theta (sprot)

description: A diacylglycerol kinase theta that is encoded in the genome of human.


name: NDST1_HUMAN Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (sprot)

description: A bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate.


name: NDST2_HUMAN Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (sprot)

description: A bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 that is encoded in the genome of human.


name: regulation of angiotensin levels in blood

description: The process that modulates the level of any of the various angiotensinogen proteolytic products in the blood. This occurs by the proteolytic cleavage of angiotensinogen, and its proteolytic products, to create a variety of active peptide hormones, such as angiotensin I and angiotensin II, as well as through the removal of these peptides from the circulation.


name: THOP1_HUMAN Thimet oligopeptidase (sprot)

description: A thimet oligopeptidase that is encoded in the genome of human.


name: AK1C2_HUMAN Aldo-keto reductase family 1 member C2 (sprot)

description: An aldo-keto reductase family 1 member C2 that is encoded in the genome of human.


description: Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol.


name: CAZA1_HUMAN F-actin-capping protein subunit alpha-1 (sprot)

description: An F-actin-capping protein subunit alpha-1 that is encoded in the genome of human.


name: HMGA2_HUMAN High mobility group protein HMGI-C (sprot)

description: A high mobility group protein HMGI-C that is encoded in the genome of human.


MH1 domain binding

description: Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors.


mesodermal-endodermal cell signaling

description: Any process that mediates the transfer of information from mesodermal cells to endodermal cells.


name: negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

description: Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.


name: CRIP2_HUMAN Cysteine-rich protein 2 (sprot)

description: A cysteine-rich protein 2 that is encoded in the genome of human.


name: PDX1_HUMAN Pancreas/duodenum homeobox protein 1 (sprot)

description: A pancreas/duodenum homeobox protein 1 that is encoded in the genome of human.


response to vitamin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.


name: type B pancreatic cell apoptotic process

description: Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin.


name: positive regulation of type B pancreatic cell proliferation

description: Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation.


name: NUP98_HUMAN Nuclear pore complex protein Nup98-Nup96 (sprot)

description: A nuclear pore complex protein Nup98-Nup96 that is encoded in the genome of human.


nuclear pore outer ring

description: A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).


name: GBX2_HUMAN Homeobox protein GBX-2 (sprot)

description: A homeobox protein GBX-2 that is encoded in the genome of human.


description: The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.


autonomic nervous system development

description: The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands.


name: NKX25_HUMAN Homeobox protein Nkx-2.5 (sprot)

description: A homeobox protein Nkx-2.5 that is encoded in the genome of human.


bundle of His development

description: The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers.


Purkinje myocyte differentiation

description: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle.


cardiac ventricle formation

description: The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.


name: right ventricular cardiac muscle tissue morphogenesis

description: The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized.


septum secundum development

description: The progression of the septum secundum over time, from its initial formation to the mature structure.


pulmonary myocardium development

description: The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein.


name: positive regulation of cardioblast differentiation

description: Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.


ventricular cardiac myofibril assembly

description: The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.


name: atrioventricular node cell fate commitment

description: The commitment of cells to atrioventricular (AV) node cell fates and their capacity to differentiate into AV node cells.


name: embryonic heart tube left/right pattern formation

description: The pattern specification process that results in the subdivision of the left/right axis of the embryonic heart tube in space to define an area or volume in which specific patterns of cell differentiation will take place.


Nkx-2.5 complex

description: A transcription factor complex formed by two or more subunits of Nkx-2.5. Nkx-2.5 is an evolutionary conserved transcription factor important for the specification and differentiation of cardiomyocytes during heart development. It is also required for spleen development. It binds DNA either as a monomer, or a homodimer, or a heterodimer complex to activate or inhibit expression of genes.


name: LBX1_HUMAN Transcription factor LBX1 (sprot)

description: A transcription factor LBX1 that is encoded in the genome of human.


name: negative regulation of glutamatergic neuron differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic neuron differentiation.


glutamatergic neuron differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a glutamatergic neuron.


name: NAR1_HUMAN GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (sprot)

description: A GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 that is encoded in the genome of human.


name: BIEA_HUMAN Biliverdin reductase A (sprot)

description: A biliverdin reductase A that is encoded in the genome of human.


name: TXTP_HUMAN Tricarboxylate transport protein, mitochondrial (sprot)

description: A tricarboxylate transport protein, mitochondrial that is encoded in the genome of human.


name: citrate transmembrane transporter activity

description: Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other.


name: tricarboxylic acid transmembrane transporter activity

description: Enables the transfer of tricarboxylic acids from one side of a membrane to the other. Tricarboxylic acid are organic acids with three COOH groups.


name: citrate secondary active transmembrane transporter activity

description: Enables the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.


name: mitochondrial citrate transmembrane transport

description: The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into or out of a mitochondrial matrix.


name: PPP5_HUMAN Serine/threonine-protein phosphatase 5 (sprot)

description: A serine/threonine-protein phosphatase 5 that is encoded in the genome of human.


response to arachidonic acid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arachidonic acid stimulus.


name: PLK1_HUMAN Serine/threonine-protein kinase PLK1 (sprot)

description: A serine/threonine-protein kinase PLK1 that is encoded in the genome of human.


Golgi inheritance

description: The partitioning of Golgi apparatus between daughter cells at cell division.


synaptonemal complex disassembly

description: The controlled breakdown of a synaptonemal complex.


name: protein localization to nuclear envelope

description: A process in which a protein is transported to, or maintained at, a location within a nuclear envelope.


name: regulation of protein localization to cell cortex

description: Any process that modulates the frequency, rate or extent of protein localization to cell cortex.


name: DAPK1_HUMAN Death-associated protein kinase 1 (sprot)

description: A death-associated protein kinase 1 that is encoded in the genome of human.


regulation of response to tumor cell

description: Any process that modulates the frequency, rate, or extent of a response to tumor cell.


name: positive regulation of autophagic cell death

description: Any process that activates or increases the frequency, rate or extent of autophagic cell death.


DAPK1-calmodulin complex

description: A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding.


ARFP2_HUMAN Arfaptin-2 (sprot)

An arfaptin-2 that is encoded in the genome of human.


membrane curvature sensor activity

description: Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins.


ARFP1_HUMAN Arfaptin-1 (sprot)

An arfaptin-1 that is encoded in the genome of human.


name: negative regulation of retrograde transport, endosome to Golgi

description: Any process that stops, prevents or reduces the frequency, rate or extent of retrograde transport, endosome to Golgi.


name: NUDT6_HUMAN Nucleoside diphosphate-linked moiety X motif 6 (sprot)

description: A nucleoside diphosphate-linked moiety X motif 6 that is encoded in the genome of human.


name: NUBP1_HUMAN Cytosolic Fe-S cluster assembly factor NUBP1 (sprot)

description: A cytosolic Fe-S cluster assembly factor NUBP1 that is encoded in the genome of human.


ATP-dependent FeS chaperone activity

description: Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis.


ACLY_HUMAN ATP-citrate synthase (sprot)

An ATP-citrate synthase that is encoded in the genome of human.


ATP citrate synthase activity

description: Catalysis of the reaction: acetyl-CoA + ADP + H+ + oxaloacetate + phosphate = ATP + citrate + CoA.


name: CO4A4_HUMAN Collagen alpha-4(IV) chain (sprot)

description: A collagen alpha-4(IV) chain that is encoded in the genome of human.


FOSB_HUMAN Protein FosB (sprot)

A protein FosB that is encoded in the genome of human.


name: CEBPG_HUMAN CCAAT/enhancer-binding protein gamma (sprot)

description: A CCAAT/enhancer-binding protein gamma that is encoded in the genome of human.


name: MAP11_HUMAN Methionine aminopeptidase 1 (sprot)

description: A methionine aminopeptidase 1 that is encoded in the genome of human.


name: SUCA_HUMAN Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (sprot)

description: A succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial that is encoded in the genome of human.


name: succinate-CoA ligase complex (ADP-forming)

description: A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP.


name: succinate-CoA ligase complex (GDP-forming)

description: A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP.


name: MVD1_HUMAN Diphosphomevalonate decarboxylase (sprot)

description: A diphosphomevalonate decarboxylase that is encoded in the genome of human.


description: Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO2 + H+ + isopentenyl diphosphate + phosphate.


name: PGTB1_HUMAN Geranylgeranyl transferase type-1 subunit beta (sprot)

description: A geranylgeranyl transferase type-1 subunit beta that is encoded in the genome of human.


description: Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.


name: PGTB2_HUMAN Geranylgeranyl transferase type-2 subunit beta (sprot)

description: A geranylgeranyl transferase type-2 subunit beta that is encoded in the genome of human.


name: COPB_HUMAN Coatomer subunit beta (sprot)

description: A coatomer subunit beta that is encoded in the genome of human.


name: COPA_HUMAN Coatomer subunit alpha (sprot)

description: A coatomer subunit alpha that is encoded in the genome of human.


name: CATC_HUMAN Dipeptidyl peptidase 1 (sprot)

description: A dipeptidyl peptidase 1 that is encoded in the genome of human.


name: positive regulation of proteolysis involved in protein catabolic process

description: Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process.


LIMK1_HUMAN LIM domain kinase 1 (sprot)

A LIM domain kinase 1 that is encoded in the genome of human.


LIMK2_HUMAN LIM domain kinase 2 (sprot)

A LIM domain kinase 2 that is encoded in the genome of human.


CRBA2_HUMAN Beta-crystallin A2 (sprot)

A beta-crystallin A2 that is encoded in the genome of human.


CRBA4_HUMAN Beta-crystallin A4 (sprot)

A beta-crystallin A4 that is encoded in the genome of human.


CRBB1_HUMAN Beta-crystallin B1 (sprot)

A beta-crystallin B1 that is encoded in the genome of human.


name: CLH2_HUMAN Clathrin heavy chain 2 (sprot)

description: A clathrin heavy chain 2 that is encoded in the genome of human.


name: AP3M2_HUMAN AP-3 complex subunit mu-2 (sprot)

description: An AP-3 complex subunit mu-2 that is encoded in the genome of human.


name: AP2S1_HUMAN AP-2 complex subunit sigma (sprot)

description: An AP-2 complex subunit sigma that is encoded in the genome of human.


name: CCHL_HUMAN Holocytochrome c-type synthase (sprot)

description: A holocytochrome c-type synthase that is encoded in the genome of human.


holocytochrome-c synthase activity

description: Catalysis of the reaction: holocytochrome c = apocytochrome c + heme.


cytochrome c-heme linkage

description: The linkage of cytochromes and other heme proteins to heme.


ITA8_HUMAN Integrin alpha-8 (sprot)

An integrin alpha-8 that is encoded in the genome of human.


name: MK12_HUMAN Mitogen-activated protein kinase 12 (sprot)

description: A mitogen-activated protein kinase 12 that is encoded in the genome of human.


name: MK10_HUMAN Mitogen-activated protein kinase 10 (sprot)

description: A mitogen-activated protein kinase 10 that is encoded in the genome of human.


name: SC5A3_HUMAN Sodium/myo-inositol cotransporter (sprot)

description: A sodium/myo-inositol cotransporter that is encoded in the genome of human.


name: myo-inositol transmembrane transporter activity

description: Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms.


name: polyol transmembrane transporter activity

description: Enables the transfer of a polyol from one side of a membrane to the other. A polyol is any polyhydric alcohol.


polyol transmembrane transport

description: The directed movement of polyols, any polyhydric alcohol, across a membrane.


name: myo-inositol import across plasma membrane

description: The directed movement of myo-inositol from outside of a cell, across the plasma membrane and into the cytosol.


name: PTTG_HUMAN Pituitary tumor-transforming gene 1 protein-interacting protein (sprot)

description: A pituitary tumor-transforming gene 1 protein-interacting protein that is encoded in the genome of human.


name: RPAB4_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC4 (sprot)

description: A DNA-directed RNA polymerases I, II, and III subunit RPABC4 that is encoded in the genome of human.


name: regulation of transcription by RNA polymerase I

description: Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I.


name: TTC3_HUMAN E3 ubiquitin-protein ligase TTC3 (sprot)

description: An E3 ubiquitin-protein ligase TTC3 that is encoded in the genome of human.


RCAN1_HUMAN Calcipressin-1 (sprot)

A calcipressin-1 that is encoded in the genome of human.


SMTN_HUMAN Smoothelin (sprot)

A smoothelin that is encoded in the genome of human.


name: PLAT3_HUMAN Phospholipase A and acyltransferase 3 (sprot)

description: A phospholipase A and acyltransferase 3 that is encoded in the genome of human.


N-acyltransferase activity

description: Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.


membrane disassembly

description: The controlled breakdown of any cell membrane in the context of a normal process such as autophagy.


description: Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains.


ether lipid metabolic process

description: The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.


description: The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group.


name: regulation of adipose tissue development

description: Any process that modulates the frequency, rate or extent of adipose tissue development.


name: MOT1_HUMAN Monocarboxylate transporter 1 (sprot)

description: A monocarboxylate transporter 1 that is encoded in the genome of human.


name: mevalonate transmembrane transporter activity

description: Enables the transfer of mevalonate from one side of a membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds.


name: succinate transmembrane transporter activity

description: Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other.


mevalonate transport

description: The directed movement of mevalonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


plasma membrane lactate transport

description: The directed movement of lactate across a plasma membrane.


behavioral response to nutrient

description: Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus.


succinate transmembrane transport

description: The process in which succinate is transported across a membrane.


IST1_HUMAN IST1 homolog (sprot)

An IST1 homolog that is encoded in the genome of human.


MIT domain binding

description: Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking.


abscission

description: The controlled shedding of a body part.


viral capsid secondary envelopment

description: The process in which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope.


name: SC24C_HUMAN Protein transport protein Sec24C (sprot)

description: A protein transport protein Sec24C that is encoded in the genome of human.


name: TCP4_HUMAN Activated RNA polymerase II transcriptional coactivator p15 (sprot)

description: An activated RNA polymerase II transcriptional coactivator p15 that is encoded in the genome of human.


RNA polymerase II promoter clearance

description: A process that mediates the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.


name: negative regulation of DNA metabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.


name: DPOG1_HUMAN DNA polymerase subunit gamma-1 (sprot)

description: A DNA polymerase subunit gamma-1 that is encoded in the genome of human.


name: single-stranded DNA 3'-5' DNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule.


DNA replication proofreading

description: Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity.


name: ICLN_HUMAN Methylosome subunit pICln (sprot)

description: A methylosome subunit pICln that is encoded in the genome of human.


pICln-Sm protein complex

description: A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.


name: CRIS1_HUMAN Cysteine-rich secretory protein 1 (sprot)

description: A cysteine-rich secretory protein 1 that is encoded in the genome of human.


name: CRIS3_HUMAN Cysteine-rich secretory protein 3 (sprot)

description: A cysteine-rich secretory protein 3 that is encoded in the genome of human.


name: BLM_HUMAN RecQ-like DNA helicase BLM (sprot)

description: A RecQ-like DNA helicase BLM that is encoded in the genome of human.


four-way junction helicase activity

description: Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis.


forked DNA-dependent helicase activity

description: Unwinding a DNA helix containing forked DNA, driven by ATP hydrolysis.


telomeric G-quadruplex DNA binding

description: Binding to telomeric G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures in telomeres.


8-hydroxy-2'-deoxyguanosine DNA binding

description: Binding to 8-hydroxy-2'-deoxyguanosine an oxidized purine residue found in damaged DNA.


name: resolution of DNA recombination intermediates

description: The cleavage and rejoining of intermediates, such as Holliday junctions, formed during DNA recombination to produce two intact molecules in which genetic material has been exchanged.


name: regulation of DNA-templated DNA replication

description: Any process that modulates the rate, frequency, or extent of DNA-templated DNA replication, the process in which new strands of DNA are synthesized.


name: RecQ family helicase-topoisomerase III complex

description: A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human.


name: SYRC_HUMAN Arginine--tRNA ligase, cytoplasmic (sprot)

description: An arginine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


arginine-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).


arginyl-tRNA aminoacylation

description: The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


HIRA_HUMAN Protein HIRA (sprot)

A protein HIRA that is encoded in the genome of human.


name: VMAT1_HUMAN Chromaffin granule amine transporter (sprot)

description: A chromaffin granule amine transporter that is encoded in the genome of human.


name: monoamine:proton antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out).


ATX3_HUMAN Ataxin-3 (sprot)

An ataxin-3 that is encoded in the genome of human.


cellular response to misfolded protein

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.


name: protein localization to cytosolic proteasome complex

description: A process in which a protein is transported to, or maintained in, a location within a cytosolic proteasome complex.


ATX1_HUMAN Ataxin-1 (sprot)

An ataxin-1 that is encoded in the genome of human.


poly(G) binding

description: Binding to a sequence of guanine residues in an RNA molecule.


name: HAP1_HUMAN Huntingtin-associated protein 1 (sprot)

description: A huntingtin-associated protein 1 that is encoded in the genome of human.


name: positive regulation of neurotrophin production

description: Any process that activates or increases the frequency, rate, or extent of production of a neurotrophin.


ATN1_HUMAN Atrophin-1 (sprot)

An atrophin-1 that is encoded in the genome of human.


name: TERF1_HUMAN Telomeric repeat-binding factor 1 (sprot)

description: A telomeric repeat-binding factor 1 that is encoded in the genome of human.


ankyrin repeat binding

description: Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure.


telomere capping

description: A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins.


name: negative regulation of telomere maintenance via semi-conservative replication

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA.


name: positive regulation of shelterin complex assembly

description: Any process that activates or increases the frequency, rate or extent of shelterin complex assembly.


name: negative regulation of establishment of protein localization to telomere

description: Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to telomere.


name: negative regulation of establishment of RNA localization to telomere

description: Any process that stops, prevents or reduces the frequency, rate or extent of establishment of RNA localization to telomere.


name: negative regulation of establishment of protein-containing complex localization to telomere

description: Any process that stops, prevents or reduces the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere.


name: negative regulation of exonuclease activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of exonuclease activity.


name: negative regulation of telomeric D-loop disassembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of telomeric D-loop disassembly.


shelterin complex

description: A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1.


name: PMS1_HUMAN PMS1 protein homolog 1 (sprot)

description: A PMS1 protein homolog 1 that is encoded in the genome of human.


name: PMS2_HUMAN Mismatch repair endonuclease PMS2 (sprot)

description: A mismatch repair endonuclease PMS2 that is encoded in the genome of human.


name: single base insertion or deletion binding

description: Binding to a double-stranded DNA region containing a single base insertion or deletion.


name: CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3 (sprot)

description: A voltage-dependent L-type calcium channel subunit beta-3 that is encoded in the genome of human.


name: calcium ion transmembrane transport via high voltage-gated calcium channel

description: A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel.


name: regulation of membrane repolarization during action potential

description: Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential.


name: L-type voltage-gated calcium channel complex

description: A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.


name: CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1 (sprot)

description: A voltage-dependent calcium channel subunit alpha-2/delta-1 that is encoded in the genome of human.


name: voltage-gated calcium channel activity involved in cardiac muscle cell action potential

description: Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: voltage-gated calcium channel activity involved in bundle of His cell action potential

description: Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: membrane depolarization during bundle of His cell action potential

description: The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


MYOM2_HUMAN Myomesin-2 (sprot)

A myomesin-2 that is encoded in the genome of human.


name: LIPR1_HUMAN Inactive pancreatic lipase-related protein 1 (sprot)

description: A pancreatic lipase-related protein 1 that is encoded in the genome of human.


name: LIPR2_HUMAN Pancreatic lipase-related protein 2 (sprot)

description: A pancreatic lipase-related protein 2 that is encoded in the genome of human.


galactolipase activity

description: Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates.