Mpp10 complex

description: A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p.


category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family and associated proteins. Many are involved in a step of processing of rRNA molecules: cleavage, 2'-O-methylation, or pseudouridylation, but other RNA types can be targets as well. The majority fall into one of two classes, box C/D type or box H/ACA type, which are conserved across eukaryotes and archaea. Other members include the telomerase RNA and the ribonuclease MRP RNA.


small-subunit processome

description: A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.


name: NOP56_HUMAN Nucleolar protein 56 (sprot)

description: A nucleolar protein 56 that is encoded in the genome of human.


snoRNA binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to a small nucleolar RNA.


histone methyltransferase binding

description: Binding to a histone methyltransferase enzyme.


name: box C/D methylation guide snoRNP complex

description: A ribonucleoprotein complex containing a box C/D type RNA that is capable of ribose-2'-O-methylation of target RNAs. Box C/D type RNAs are widespread in eukaryotes and in Archaea, suggesting that an RNA-based guide mechanism for directing specific RNA 2'-O-ribose methylations was present in the common ancestor of Archaea and Eukarya.


pre-snoRNP complex

description: A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes.


name: SOX1_HUMAN Transcription factor SOX-1 (sprot)

description: A transcription factor SOX-1 that is encoded in the genome of human.


forebrain neuron development

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell.


name: regulation of oligodendrocyte differentiation

description: Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation.


name: DDX3X_HUMAN ATP-dependent RNA helicase DDX3X (sprot)

description: An ATP-dependent RNA helicase DDX3X that is encoded in the genome of human.


DNA helicase activity

description: Unwinding of a DNA helix, driven by ATP hydrolysis.


poly(A) binding

description: Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.


eukaryotic initiation factor 4E binding

description: Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation.


name: ribonucleoside triphosphate phosphatase activity

description: Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate.


RNA strand annealing activity

description: An activity that facilitates the formation of a complementary double-stranded RNA molecule.


RNA stem-loop binding

description: Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.


gamma-tubulin binding

description: Binding to the microtubule constituent protein gamma-tubulin.


ribosomal small subunit binding

description: Binding to a small ribosomal subunit.


CTPase activity

description: Catalysis of the reaction: CTP + H2O = CDP + H+ + phosphate. May or may not be coupled to another reaction.


RNA secondary structure unwinding

description: The process in which a secondary structure of RNA are broken or 'melted'.


negative regulation of cell growth

description: Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.


name: negative regulation of protein-containing complex assembly

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.


name: positive regulation of protein autophosphorylation

description: Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues.


name: positive regulation of type I interferon production

description: Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


stress granule assembly

description: The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.


name: positive regulation of toll-like receptor 7 signaling pathway

description: Any process that activates or increases the frequency, rate, or extent of toll-like receptor 7 signaling pathway.


name: positive regulation of toll-like receptor 8 signaling pathway

description: Any process that activates or increases the frequency, rate, or extent of toll-like receptor 8 signaling pathway.


name: positive regulation of translation in response to endoplasmic reticulum stress

description: Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.


cytosolic ribosome assembly

description: The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol.


name: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.


name: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

description: Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.


name: positive regulation of translational initiation

description: Any process that activates or increases the frequency, rate or extent of translational initiation.


lipid homeostasis

description: Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.


name: cellular response to arsenic-containing substance

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.


cellular response to osmotic stress

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


name: positive regulation of chemokine (C-C motif) ligand 5 production

description: Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5.


intrinsic apoptotic signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).


name: negative regulation of non-canonical NF-kappaB signal transduction

description: Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical NF-kappaB signaling cascade.


name: negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

description: Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.


name: positive regulation of protein K63-linked ubiquitination

description: Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination.


name: protein localization to cytoplasmic stress granule

description: A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.


name: negative regulation of intrinsic apoptotic signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.


NLRP3 inflammasome complex

description: An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.


name: CXCR6_HUMAN C-X-C chemokine receptor type 6 (sprot)

description: A C-X-C chemokine receptor type 6 that is encoded in the genome of human.


C-X-C chemokine receptor activity

description: Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif.


viral genome replication

description: Any process involved directly in viral genome replication, including viral nucleotide metabolism.


RNT2_HUMAN Ribonuclease T2 (sprot)

A ribonuclease T2 that is encoded in the genome of human.


RNA nuclease activity

description: Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.


ribonuclease T2 activity

description: Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates.


RNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.


name: CCL21_HUMAN C-C motif chemokine 21 (sprot)

description: A C-C motif chemokine 21 that is encoded in the genome of human.


positive regulation of T cell migration

description: Any process that activates or increases the frequency, rate or extent of T cell migration.


CCR7 chemokine receptor binding

description: Binding to a CCR7 chemokine receptor.


establishment of T cell polarity

description: The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.


immunological synapse formation

description: The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.


name: positive regulation of cell-matrix adhesion

description: Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.


dendritic cell chemotaxis

description: The movement of a dendritic cell in response to an external stimulus.


name: positive regulation of dendritic cell antigen processing and presentation

description: Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation.


name: positive regulation of glycoprotein biosynthetic process

description: Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.


name: positive regulation of T cell chemotaxis

description: Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.


T cell costimulation

description: The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.


ruffle organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.


name: positive regulation of cell adhesion mediated by integrin

description: Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.


response to prostaglandin E

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.


mesangial cell-matrix adhesion

description: The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney.


name: chemokine (C-C motif) ligand 21 signaling pathway

description: The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


cell maturation

description: The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state.


positive regulation of chemotaxis

description: Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.


name: release of sequestered calcium ion into cytosol

description: The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.


cell chemotaxis

description: The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).


dendritic cell dendrite assembly

description: Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells.


name: negative regulation of leukocyte tethering or rolling

description: Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling.


cellular response to chemokine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.


positive regulation of cell motility

description: Any process that activates or increases the frequency, rate or extent of cell motility.


name: positive regulation of myeloid dendritic cell chemotaxis

description: Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis.


name: negative regulation of dendritic cell dendrite assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly.


name: negative regulation of dendritic cell apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process.


name: MFNG_HUMAN Beta-1,3-N-acetylglucosaminyltransferase manic fringe (sprot)

description: A beta-1,3-N-acetylglucosaminyltransferase manic fringe that is encoded in the genome of human.


description: Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.


blastocyst formation

description: The initial formation of a blastocyst from a solid ball of cells known as a morula.


name: ACKR2_HUMAN Atypical chemokine receptor 2 (sprot)

description: An atypical chemokine receptor 2 that is encoded in the genome of human.


actin filament

description: A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.


name: GBRP_HUMAN Gamma-aminobutyric acid receptor subunit pi (sprot)

description: A gamma-aminobutyric acid receptor subunit pi that is encoded in the genome of human.


PODXL_HUMAN Podocalyxin (sprot)

A podocalyxin-like protein 1 that is encoded in the genome of human.


negative regulation of cell adhesion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.


name: negative regulation of cell-cell adhesion

description: Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.


regulation of microvillus assembly

description: A process that modulates the formation of a microvillus.


name: positive regulation of cell-cell adhesion mediated by integrin

description: Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin.


podocyte development

description: The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells.


epithelial tube formation

description: The developmental process pertaining to the initial formation of an epithelial tube.


slit diaphragm

description: A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.


FCN1_HUMAN Ficolin-1 (sprot)

A ficolin-1 that is encoded in the genome of human.


pattern recognition receptor activity

description: Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response.


name: cell surface pattern recognition receptor signaling pathway

description: The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.


recognition of apoptotic cell

description: The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis.


name: negative regulation of viral entry into host cell

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell.


positive regulation of opsonization

description: Any process that activates or increases the frequency, rate or extent of opsonization.


serine-type endopeptidase complex

description: A protein complex which is capable of serine-type endopeptidase activity.


CCN1_HUMAN CCN family member 1 (sprot)

A CCN family member 1 that is encoded in the genome of human.


heparin binding

description: Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.


intussusceptive angiogenesis

description: The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars.


atrioventricular valve morphogenesis

description: The process in which the structure of the atrioventricular valve is generated and organized.


name: apoptotic process involved in heart morphogenesis

description: Any apoptotic process that contributes to the shaping of the heart.


name: positive regulation of cell-substrate adhesion

description: Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.


name: positive regulation of osteoblast proliferation

description: Any process that activates or increases the rate or extent of osteoblast proliferation.


wound healing, spreading of cells

description: The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface.


name: positive regulation of protein kinase activity

description: Any process that activates or increases the frequency, rate or extent of protein kinase activity.


atrial septum morphogenesis

description: The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another.


chondroblast differentiation

description: The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes.


chorio-allantoic fusion

description: The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois.


name: labyrinthine layer blood vessel development

description: The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.


regulation of ERK1 and ERK2 cascade

description: Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.


name: reactive oxygen species metabolic process

description: The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.


name: positive regulation of ceramide biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process.


name: PEX12_HUMAN Peroxisome assembly protein 12 (sprot)

description: A peroxisome assembly protein 12 that is encoded in the genome of human.


ubiquitin ligase activator activity

description: Binds to and increases the activity of a ubiquitin ligase.


name: protein quality control for misfolded or incompletely synthesized proteins

description: The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.


protein targeting to peroxisome

description: The process of directing proteins towards the peroxisome, usually using signals contained within the protein.


peroxisome organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.


protein import into peroxisome matrix

description: The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix.


name: protein import into peroxisome matrix, receptor recycling

description: The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol.


name: cellular response to reactive oxygen species

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.


name: protein import into peroxisome matrix, substrate release

description: The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane.


name: NPT3_HUMAN Sodium-dependent phosphate transport protein 3 (sprot)

description: A sodium-dependent phosphate transport protein 3 that is encoded in the genome of human.


name: phosphate-containing compound metabolic process

description: The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.


PIR_HUMAN Pirin (sprot)

A pirin that is encoded in the genome of human.


monocyte differentiation

description: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.


quercetin 2,3-dioxygenase activity

description: Catalysis of the reaction: H+ + O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO.


name: CCL22_HUMAN C-C motif chemokine 22 (sprot)

description: A C-C motif chemokine 22 that is encoded in the genome of human.


name: PEX7_HUMAN Peroxisomal targeting signal 2 receptor (sprot)

description: A peroxisomal targeting signal 2 receptor that is encoded in the genome of human.


name: peroxisome matrix targeting signal-2 binding

description: Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F).


endochondral ossification

description: Replacement ossification wherein bone tissue replaces cartilage.


fatty acid beta-oxidation

description: A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).


name: IMA3_HUMAN Importin subunit alpha-3 (sprot)

description: An importin subunit alpha-3 that is encoded in the genome of human.


dopamine secretion

description: The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone.


SARCO_HUMAN Sarcolipin (sprot)

A sarcolipin that is encoded in the genome of human.


enzyme inhibitor activity

description: Binds to and stops, prevents or reduces the activity of an enzyme.


name: negative regulation of catalytic activity

description: Any process that stops or reduces the activity of an enzyme.


name: negative regulation of protein-containing complex disassembly

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.


regulation of calcium ion transport

description: Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: sarcoplasmic reticulum calcium ion transport

description: The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum.


name: negative regulation of calcium ion import

description: Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.


name: positive regulation of cold-induced thermogenesis

description: Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.


name: negative regulation of calcium ion transmembrane transporter activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transporter activity.


regulation of relaxation of muscle

description: Any process that modulates the frequency, rate or extent of relaxation of muscle.


name: negative regulation of calcium ion binding

description: Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion binding.


name: positive regulation of protein depolymerization

description: Any process that activates or increases the frequency, rate or extent of protein depolymerization.


name: regulation of ATPase-coupled calcium transmembrane transporter activity

description: Any process that modulates the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity.


name: negative regulation of ATPase-coupled calcium transmembrane transporter activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity.


NET3_HUMAN Netrin-3 (sprot)

A netrin-3 that is encoded in the genome of human.


name: TRI38_HUMAN E3 ubiquitin-protein ligase TRIM38 (sprot)

description: An E3 ubiquitin-protein ligase TRIM38 that is encoded in the genome of human.


name: regulation of interferon-beta production

description: Any process that modulates the frequency, rate, or extent of interferon-beta production.


protein K48-linked ubiquitination

description: A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.


name: NFIB_HUMAN Nuclear factor 1 B-type (sprot)

description: A nuclear factor 1 B-type that is encoded in the genome of human.


tissue homeostasis

description: A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.


chondrocyte differentiation

description: The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.


name: glandular epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.


glial cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.


exit from mitosis

description: The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.


glial cell proliferation

description: The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others.


stem cell population maintenance

description: The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.


name: principal sensory nucleus of trigeminal nerve development

description: The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure.


glial cell fate specification

description: The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.


cell proliferation in forebrain

description: The creation of greater cell numbers in the forebrain due to cell division of progenitor cells.


anterior commissure morphogenesis

description: Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum.


hindbrain development

description: The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).


regeneration

description: The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass).


club cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles.


type I pneumocyte differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles.


type II pneumocyte differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies.


salivary gland cavitation

description: The process in which the solid core of salivary epithelium gives rise to the hollow tube of the gland.


name: cell differentiation involved in salivary gland development

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland.


lung ciliated cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells.


commissural neuron axon guidance

description: The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.


name: negative regulation of miRNA transcription

description: Any process that stops, prevents or reduces the frequency, rate or extent of microRNA (miRNA) gene transcription.


name: negative regulation of stem cell proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation.


name: negative regulation of mesenchymal cell proliferation involved in lung development

description: Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.


name: negative regulation of epithelial cell proliferation involved in lung morphogenesis

description: Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis.


name: E2F3_HUMAN Transcription factor E2F3 (sprot)

description: A transcription factor E2F3 that is encoded in the genome of human.


name: DNA-binding transcription activator activity

description: A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets.


name: negative regulation of fat cell proliferation

description: Any process that stops or decreases the rate or extent of fat cell proliferation.


name: positive regulation of vascular associated smooth muscle cell apoptotic process

description: Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.


name: PPP6_HUMAN Serine/threonine-protein phosphatase 6 catalytic subunit (sprot)

description: A serine/threonine-protein phosphatase 6 catalytic subunit that is encoded in the genome of human.


protein dephosphorylation

description: The process of removing one or more phosphoric residues from a protein.


COPII vesicle coating

description: The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.


WN10B_HUMAN Protein Wnt-10b (sprot)

A protein Wnt-10b that is encoded in the genome of human.


G2/M transition of mitotic cell cycle

description: The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.


name: myoblast differentiation involved in skeletal muscle regeneration

description: The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


neuron differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a neuron.


name: positive regulation of epithelial cell differentiation

description: Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.


name: regulation of proteasomal ubiquitin-dependent protein catabolic process

description: Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


name: positive regulation of T cell differentiation

description: Any process that activates or increases the frequency, rate or extent of T cell differentiation.


name: positive regulation of RNA polymerase II transcription preinitiation complex assembly

description: Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.


myoblast development

description: The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


name: regulation of skeletal muscle tissue development

description: Any process that modulates the frequency, rate or extent of skeletal muscle tissue development.


skeletal muscle fiber development

description: The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.


name: negative regulation of epithelial cell proliferation

description: Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.


sensory perception of taste

description: The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.


positive regulation of timing of anagen

description: Any process that activates or increases the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle.


canonical Wnt signaling pathway

description: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.


bone trabecula formation

description: The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod.


fungiform papilla development

description: The progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue.


name: cellular response to parathyroid hormone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus.


name: positive regulation of hematopoietic stem cell proliferation

description: Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation.


name: NDKM_HUMAN Nucleoside diphosphate kinase, mitochondrial (sprot)

description: A nucleoside diphosphate kinase, mitochondrial that is encoded in the genome of human.


cardiolipin binding

description: Binding to cardiolipin.


GTP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate.


UTP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate.


CTP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate.


nucleoside metabolic process

description: The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine).


EST2_HUMAN Cocaine esterase (sprot)

A cocaine esterase that is encoded in the genome of human.


description: Catalysis of the reaction: 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H+.


carboxylesterase activity

description: Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+.


prostaglandin metabolic process

description: The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.


catabolic process

description: The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.


name: P3C2B_HUMAN Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (sprot)

description: A phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta that is encoded in the genome of human.


autophagosome organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome.


name: MA2B1_HUMAN Lysosomal alpha-mannosidase (sprot)

description: A lysosomal alpha-mannosidase that is encoded in the genome of human.


mannose metabolic process

description: The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.


protein deglycosylation

description: The removal of sugar residues from a glycosylated protein.


WNT7A_HUMAN Protein Wnt-7a (sprot)

A protein Wnt-7a that is encoded in the genome of human.


embryonic axis specification

description: The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.


neurotransmitter secretion

description: The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.


sex differentiation

description: The establishment of the sex of an organism by physical differentiation.


name: skeletal muscle satellite cell activation

description: The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.


name: skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration

description: Any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells.


cerebellar granule cell differentiation

description: The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.


central nervous system vasculogenesis

description: The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier.


establishment of cell polarity

description: The specification and formation of anisotropic intracellular organization or cell growth patterns.


regulation of axon diameter

description: Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained.


response to estradiol

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.


embryonic forelimb morphogenesis

description: The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.


embryonic hindlimb morphogenesis

description: The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal.


name: wound healing, spreading of epidermal cells

description: The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis.


synaptic vesicle recycling

description: The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane.


embryonic digit morphogenesis

description: The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.


name: asymmetric protein localization involved in cell fate determination

description: Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.


somatic stem cell division

description: The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line.


stem cell development

description: The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate.


negative regulation of neurogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.


name: positive regulation of protein metabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.


oviduct development

description: The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism.


name: Wnt signaling pathway, planar cell polarity pathway

description: A type of non-canonical Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the activation small G proteins such as Rho, Rac, and Cdc42 which, in turn activate effectors, including C-Jun N-terminal kinase (JNK) and Rho kinase (Rok). The signaling ends with change in the transcription of target genes and/or reorganisation of the cytoskeleton.


establishment of blood-brain barrier

description: Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.


uterus morphogenesis

description: The process in which anatomical structures of the uterus are generated and organized.


secondary palate development

description: The biological process whose specific outcome is the progression of the secondary palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The secondary palate is the part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences.


lens fiber cell development

description: The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.


postsynapse assembly

description: The aggregation, arrangement and bonding together of a set of components to form a postsynapse.


excitatory synapse assembly

description: The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse.


name: positive regulation of protein localization to presynapse

description: Any process that activates or increases the frequency, rate or extent of protein localization to presynapse.


regulation of presynapse assembly

description: Any process that modulates the frequency, rate or extent of presynapse assembly.


name: positive regulation of excitatory postsynaptic potential

description: Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.


name: F16P2_HUMAN Fructose-1,6-bisphosphatase isozyme 2 (sprot)

description: A fructose-1,6-bisphosphatase isozyme 2 that is encoded in the genome of human.


gluconeogenesis

description: The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.


name: UBE2C_HUMAN Ubiquitin-conjugating enzyme E2 C (sprot)

description: A ubiquitin-conjugating enzyme E2 C that is encoded in the genome of human.


ubiquitin-like protein ligase binding

description: Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase.


free ubiquitin chain polymerization

description: The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein.


name: anaphase-promoting complex-dependent catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.


name: positive regulation of exit from mitosis

description: Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).


name: positive regulation of mitotic metaphase/anaphase transition

description: Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.


protein K11-linked ubiquitination

description: A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.


name: positive regulation of ubiquitin protein ligase activity

description: Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity.


anaphase-promoting complex

description: A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.


name: ACACB_HUMAN Acetyl-CoA carboxylase 2 (sprot)

description: An acetyl-CoA carboxylase 2 that is encoded in the genome of human.


acetyl-CoA carboxylase activity

description: Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.


biotin binding

description: Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.


acetyl-CoA metabolic process

description: The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.


pentose-phosphate shunt

description: The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate).


positive regulation of lipid storage

description: Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.


regulation of glucose metabolic process

description: Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.


response to organic cyclic compound

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.


fatty acid oxidation

description: The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.


name: negative regulation of fatty acid beta-oxidation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation.


lactic acid secretion

description: The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or a tissue.


protein homotetramerization

description: The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.


positive regulation of heart growth

description: Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.


tricarboxylic acid metabolic process

description: The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-).


intracellular aspartate homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of aspartate within a cell.


intracellular glutamate homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of glutamate within a cell.


name: regulation of cardiac muscle hypertrophy in response to stress

description: Any process that modulates the frequency, rate or extent of cardiac muscle hypertrophy in response to stress.


malonyl-CoA biosynthetic process

description: The chemical reactions and pathways resulting in the formation of malonyl-CoA, the S-malonyl derivative of coenzyme A.


name: mitochondrial fatty acid beta-oxidation multienzyme complex

description: A multienzyme complex possessing three activities in two subunits (alpha and beta) that catalyzes three steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix. The alpha subunit comprises the enoyl-CoA hydratase (ECH) and 3-hydroxyacyl-CoA dehydrogenase (HACD) activities, and the beta subunit contains the acetyl-CoA C-acyltransferase (KACT)/thiolase activity.


PDXK_HUMAN Pyridoxal kinase (sprot)

A pyridoxal kinase that is encoded in the genome of human.


pyridoxal kinase activity

description: Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.


pyridoxal phosphate binding

description: Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.


potassium ion binding

description: Binding to a potassium ion (K+).


sodium ion binding

description: Binding to a sodium ion (Na+).


lithium ion binding

description: Binding to a lithium ion (Li+).


pyridoxal 5'-phosphate salvage

description: Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis.


pyridoxal metabolic process

description: The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.


pyridoxamine metabolic process

description: The chemical reactions and pathways involving 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.


name: SCD_HUMAN Stearoyl-CoA desaturase (sprot)

description: A stearoyl-CoA desaturase that is encoded in the genome of human.


stearoyl-CoA 9-desaturase activity

description: Catalysis of the reaction: 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O.


name: DLGP1_HUMAN Disks large-associated protein 1 (sprot)

description: A disks large-associated protein 1 that is encoded in the genome of human.


name: SH2B2_HUMAN SH2B adapter protein 2 (sprot)

description: An SH2B adapter protein 2 that is encoded in the genome of human.


B-1 B cell homeostasis

description: The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.


cytokine-mediated signaling pathway

description: The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


regulation of metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.


name: regulation of Ras protein signal transduction

description: Any process that modulates the frequency, rate or extent of Ras protein signal transduction.


brown fat cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.


CLD4_HUMAN Claudin-4 (sprot)

A claudin-4 that is encoded in the genome of human.


response to progesterone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.


renal absorption

description: A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686).


positive regulation of wound healing

description: Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.


name: positive regulation of metallopeptidase activity

description: Any process that activates or increases the frequency, rate or extent of metallopeptidase activity.


name: PLPP1_HUMAN Phospholipid phosphatase 1 (sprot)

description: A phospholipid phosphatase 1 that is encoded in the genome of human.


name: diacylglycerol diphosphate phosphatase activity

description: Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate.


phosphatidate phosphatase activity

description: Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.


description: Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate.


lipid phosphatase activity

description: Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate.


name: lysophosphatidic acid phosphatase activity

description: Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol.


description: Catalysis of the reaction: ceramide-1-phosphate + H2O = ceramide+ phosphate.


phospholipid metabolic process

description: The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.


sphingosine metabolic process

description: The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.


ceramide metabolic process

description: The chemical reactions and pathways involving ceramides, any N-acylated sphingoid.


name: protein kinase C-activating G protein-coupled receptor signaling pathway

description: The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).


regulation of lipid metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.


sphingolipid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


name: nuclear receptor-mediated steroid hormone signaling pathway

description: A nuclear receptor-mediated signaling pathway initiated by a steroid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


androgen receptor signaling pathway

description: A nuclear receptor-mediated signaling pathway initiated by an androgen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


phospholipid dephosphorylation

description: The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.


name: PLPP3_HUMAN Phospholipid phosphatase 3 (sprot)

description: A phospholipid phosphatase 3 that is encoded in the genome of human.


integrin-mediated signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


blood vessel development

description: The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.


gastrulation with mouth forming second

description: A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.


name: positive regulation of cell-cell adhesion

description: Any process that activates or increases the rate or extent of cell adhesion to another cell.


regulation of Wnt signaling pathway

description: Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.


cell-cell adhesion mediated by integrin

description: The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.


wound healing

description: The series of events that restore integrity to a damaged tissue, following an injury.


Bergmann glial cell differentiation

description: The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate.


name: regulation of sphingolipid mediated signaling pathway

description: Any process that modulates the frequency, rate or extent of sphingolipid signaling.


name: endoplasmic reticulum-Golgi intermediate compartment membrane

description: The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.


endoplasmic reticulum exit site

description: An endoplasmic reticulum part at which COPII-coated vesicles are produced.


name: ARI1A_HUMAN AT-rich interactive domain-containing protein 1A (sprot)

description: An AT-rich interactive domain-containing protein 1A that is encoded in the genome of human.


nuclear receptor binding

description: Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand.


nucleosome disassembly

description: The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.


name: regulation of mitotic metaphase/anaphase transition

description: Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.


estrogen receptor signaling pathway

description: A nuclear receptor-mediated signaling pathway initiated by an estrogen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


name: nuclear receptor-mediated glucocorticoid signaling pathway

description: A nuclear receptor-mediated signaling pathway initiated by a glucocorticoid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


name: positive regulation of cell differentiation

description: Any process that activates or increases the frequency, rate or extent of cell differentiation.


name: positive regulation of myoblast differentiation

description: Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


regulation of G0 to G1 transition

description: A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase.


name: positive regulation of stem cell population maintenance

description: Any process that activates or increases the frequency, rate or extent of stem cell population maintenance.


name: regulation of G1/S transition of mitotic cell cycle

description: Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.


name: regulation of nucleotide-excision repair

description: Any process that modulates the frequency, rate or extent of nucleotide-excision repair.


SWI/SNF complex

description: A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof.


brahma complex

description: A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the Drosophila brm (brahma) or mammalian SMARCA2/BAF190B/BRM gene, or an ortholog thereof.


npBAF complex

description: A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.


nBAF complex

description: A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.


bBAF complex

description: A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180.


name: ISLR_HUMAN Immunoglobulin superfamily containing leucine-rich repeat protein (sprot)

description: An immunoglobulin superfamily containing leucine-rich repeat protein that is encoded in the genome of human.


name: BHE40_HUMAN Class E basic helix-loop-helix protein 40 (sprot)

description: A class E basic helix-loop-helix protein 40 that is encoded in the genome of human.


MRF binding

description: Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors.


regulation of circadian rhythm

description: Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.


name: entrainment of circadian clock by photoperiod

description: The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).


name: SOCS2_HUMAN Suppressor of cytokine signaling 2 (sprot)

description: A suppressor of cytokine signaling 2 that is encoded in the genome of human.


growth hormone receptor binding

description: Binding to a growth hormone receptor.


name: insulin-like growth factor receptor binding

description: Binding to an insulin-like growth factor receptor.


name: JAK pathway signal transduction adaptor activity

description: The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way.


name: cell surface receptor signaling pathway via JAK-STAT

description: A cell surface receptor signaling pathway in which ligand binding causes the receptor to dimerize, bringing the receptor-associated JAKs into close proximity. The JAKs then phosphorylate and activate each other on tyrosine residues.This leads to the activation of associated STAT protein, causing the STATs to dissociate from the receptor, translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.


lactation

description: The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.


cellular response to hormone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.


name: negative regulation of multicellular organism growth

description: Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.


name: negative regulation of receptor signaling pathway via JAK-STAT

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT.


name: growth hormone receptor signaling pathway

description: The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.


mammary gland alveolus development

description: The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland.


name: NRG2_HUMAN Pro-neuregulin-2, membrane-bound isoform (sprot)

description: A pro-neuregulin-2, membrane-bound isoform that is encoded in the genome of human.


name: SOCS7_HUMAN Suppressor of cytokine signaling 7 (sprot)

description: A suppressor of cytokine signaling 7 that is encoded in the genome of human.


name: negative regulation of signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.


name: NCKP5_HUMAN Nck-associated protein 5 (sprot)

description: A Nck-associated protein 5 that is encoded in the genome of human.


name: AGRB1_HUMAN Adhesion G protein-coupled receptor B1 (sprot)

description: An adhesion G protein-coupled receptor B1 that is encoded in the genome of human.


phosphatidylserine binding

description: Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.


peripheral nervous system development

description: The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.


name: negative regulation of protein ubiquitination

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.


apoptotic cell clearance

description: The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.


engulfment of apoptotic cell

description: The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.


regulation of synaptic plasticity

description: A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.


positive regulation of myoblast fusion

description: Any process that activates or increases the frequency, rate or extent of myoblast fusion.


name: CDKA1_HUMAN Cyclin-dependent kinase 2-associated protein 1 (sprot)

description: A cyclin-dependent kinase 2-associated protein 1 that is encoded in the genome of human.


DNA polymerase binding

description: Binding to a DNA polymerase.


DNA-templated DNA replication

description: A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.


NuRD complex

description: An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.


AQP7_HUMAN Aquaporin-7 (sprot)

An aquaporin-7 that is encoded in the genome of human.


glycerol channel activity

description: Enables the energy-independent facilitated diffusion of glycerol through a transmembrane aqueous pore or channel.


glycerol transmembrane transport

description: The directed movement of glycerol across a membrane. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.


name: DHSD_HUMAN Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (sprot)

description: A succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial that is encoded in the genome of human.


name: succinate dehydrogenase (quinone) activity

description: Catalysis of the reaction: a quinone + succinate = a quinol + fumarate.


electron transfer activity

description: A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.


ubiquinone binding

description: Binding to ubiquinone, a quinone derivative with a tail of isoprene units.


tricarboxylic acid cycle

description: A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.


name: mitochondrial electron transport, succinate to ubiquinone

description: The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II.


regulation of catecholamine secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of catecholamines.


mitochondrial envelope

description: The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.


respiratory chain complex II

description: A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.


name: PTPRT_HUMAN Receptor-type tyrosine-protein phosphatase T (sprot)

description: A receptor-type tyrosine-protein phosphatase T that is encoded in the genome of human.


name: transmembrane receptor protein tyrosine phosphatase activity

description: Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


beta-catenin binding

description: Binding to a catenin beta subunit.


thiolester hydrolase activity

description: Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.


alpha-catenin binding

description: Binding to catenin complex alpha subunit.


gamma-catenin binding

description: Binding to catenin complex gamma subunit.


delta-catenin binding

description: Binding to the delta subunit of the catenin complex.


STAT family protein binding

description: Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.


peptidyl-tyrosine dephosphorylation

description: The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.


regulation of synapse organization

description: Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).


cellular response to interleukin-6

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.


name: negative regulation of receptor signaling pathway via STAT

description: Any process that stops, prevents or reduces the frequency, rate or extent of receptor signaling via STAT.


name: peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

description: Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity.


name: C2C2L_HUMAN Phospholipid transfer protein C2CD2L (sprot)

description: A phospholipid transfer protein C2CD2L that is encoded in the genome of human.


name: cytoplasmic side of apical plasma membrane

description: The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm.


insulin binding

description: Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.


cortical endoplasmic reticulum

description: A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements.


name: NEMP1_HUMAN Nuclear envelope integral membrane protein 1 (sprot)

description: A nuclear envelope integral membrane protein 1 that is encoded in the genome of human.


erythrocyte enucleation

description: The process in which nucleated precursor cells lose their nucleus during erythrocyte maturation.


erythrocyte maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.


nuclear membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane.


ASTN1_HUMAN Astrotactin-1 (sprot)

An astrotactin-1 that is encoded in the genome of human.


name: FCHO1_HUMAN F-BAR domain only protein 1 (sprot)

description: An F-BAR domain only protein 1 that is encoded in the genome of human.


name: CUX2_HUMAN Homeobox protein cut-like 2 (sprot)

description: A homeobox protein cut-like 2 that is encoded in the genome of human.


short-term memory

description: The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.


name: positive regulation of dendrite morphogenesis

description: Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.


name: TXND9_HUMAN Thioredoxin domain-containing protein 9 (sprot)

description: A thioredoxin domain-containing protein 9 that is encoded in the genome of human.


name: DPYL4_HUMAN Dihydropyrimidinase-related protein 4 (sprot)

description: A dihydropyrimidinase-related protein 4 that is encoded in the genome of human.


filamin binding

description: Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.


name: SOCS3_HUMAN Suppressor of cytokine signaling 3 (sprot)

description: A suppressor of cytokine signaling 3 that is encoded in the genome of human.


protein kinase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a protein kinase.


name: protein tyrosine kinase inhibitor activity

description: Stops, prevents or reduces the activity of a protein tyrosine kinase.


miRNA binding

description: Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.


name: negative regulation of tyrosine phosphorylation of STAT protein

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


name: negative regulation of insulin receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.


name: branching involved in labyrinthine layer morphogenesis

description: The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer.


placenta blood vessel development

description: The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure.


T-helper 17 cell lineage commitment

description: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.


cellular response to interleukin-17

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus.


name: SOCS6_HUMAN Suppressor of cytokine signaling 6 (sprot)

description: A suppressor of cytokine signaling 6 that is encoded in the genome of human.


proteasomal protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.


name: negative regulation of T cell activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.


immunological synapse

description: An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.


name: TRAD1_HUMAN TRAF-type zinc finger domain-containing protein 1 (sprot)

description: A TRAF-type zinc finger domain-containing protein 1 that is encoded in the genome of human.


name: COX7R_HUMAN Cytochrome c oxidase subunit 7A-related protein, mitochondrial (sprot)

description: A cytochrome c oxidase subunit 7A-related protein, mitochondrial that is encoded in the genome of human.


cytochrome-c oxidase activity

description: Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.


name: G3PT_HUMAN Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (sprot)

description: A glyceraldehyde-3-phosphate dehydrogenase, testis-specific that is encoded in the genome of human.


name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity

description: Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+.


NAD binding

description: Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.


glucose metabolic process

description: The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.


name: positive regulation of glycolytic process

description: Any process that activates or increases the frequency, rate or extent of glycolysis.


name: HSPB6_HUMAN Heat shock protein beta-6 (sprot)

description: A heat shock protein beta-6 that is encoded in the genome of human.


structural constituent of eye lens

description: The action of a molecule that contributes to the structural integrity of the lens of an eye.


name: RHG33_HUMAN Rho GTPase-activating protein 33 (sprot)

description: A Rho GTPase-activating protein 33 that is encoded in the genome of human.


response to toxic substance

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.


name: regulation of dendritic spine morphogenesis

description: Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.


name: ACPM_HUMAN Acyl carrier protein, mitochondrial (sprot)

description: An acyl carrier protein, mitochondrial that is encoded in the genome of human.


acyl carrier activity

description: Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis.


fatty acid binding

description: Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.