glycolipid metabolic process

description: The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent.


name: FUT5_HUMAN 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 (sprot)

description: A 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 that is encoded in the genome of human.


name: FUT7_HUMAN Alpha-(1,3)-fucosyltransferase 7 (sprot)

description: An alpha-(1,3)-fucosyltransferase 7 that is encoded in the genome of human.


regulation of type IV hypersensitivity

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response.


name: regulation of cell adhesion molecule production

description: Any process that modulates the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.


name: regulation of leukocyte tethering or rolling

description: Any process that modulates the frequency, rate or extent of leukocyte tethering or rolling.


regulation of neutrophil extravasation

description: Any process that modulates the frequency, rate or extent of neutrophil extravasation.


name: SIA4A_HUMAN CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (sprot)

description: A CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 that is encoded in the genome of human.


name: beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R.


description: Catalysis of the reaction: beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H+.


memory B cell differentiation

description: The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody.


protein sialylation

description: A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein.


Golgi medial cisterna membrane

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The lipid bilayer surrounding any of the thin, flattened compartments that form the medial portion of the Golgi complex.


Golgi trans cisterna membrane

description: The lipid bilayer surrounding any of the thin, flattened compartments that form the trans portion of the Golgi complex.


name: SIAT6_HUMAN CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (sprot)

description: A CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase that is encoded in the genome of human.


description: Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein + H+.


name: SIA4C_HUMAN CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (sprot)

description: A CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 that is encoded in the genome of human.


name: KIF1A_HUMAN Kinesin-like protein KIF1A (sprot)

description: A kinesin-like protein KIF1A that is encoded in the genome of human.


SCRN1_HUMAN Secernin-1 (sprot)

A secernin-1 that is encoded in the genome of human.


name: HMGX3_HUMAN HMG domain-containing protein 3 (sprot)

description: An HMG domain-containing protein 3 that is encoded in the genome of human.


name: TMM94_HUMAN Transmembrane protein 94 (sprot)

description: A transmembrane protein 94 that is encoded in the genome of human.


P-type magnesium transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in).


name: magnesium ion transport from cytosol to endoplasmic reticulum

description: The directed movement of magnesium ion from cytosol to endoplasmic reticulum.


name: WASC5_HUMAN WASH complex subunit 5 (sprot)

description: A WASH complex subunit 5 that is encoded in the genome of human.


name: NU160_HUMAN Nuclear pore complex protein Nup160 (sprot)

description: A nuclear pore complex protein Nup160 that is encoded in the genome of human.


name: SCAP_HUMAN Sterol regulatory element-binding protein cleavage-activating protein (sprot)

description: A sterol regulatory element-binding protein cleavage-activating protein that is encoded in the genome of human.


sterol binding

description: Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.


name: SRBP2_HUMAN Sterol regulatory element-binding protein 2 (sprot)

description: A sterol regulatory element-binding protein 2 that is encoded in the genome of human.


C-8 sterol isomerase activity

description: Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols.


name: ARHG5_HUMAN Rho guanine nucleotide exchange factor 5 (sprot)

description: A Rho guanine nucleotide exchange factor 5 that is encoded in the genome of human.


positive regulation of protein import

description: Any process that activates or increases the frequency, rate or extent of protein import.


name: FOXO1_HUMAN Forkhead box protein O1 (sprot)

description: A forkhead box protein O1 that is encoded in the genome of human.


name: TBL3_HUMAN Transducin beta-like protein 3 (sprot)

description: A transducin beta-like protein 3 that is encoded in the genome of human.


name: TF3C1_HUMAN General transcription factor 3C polypeptide 1 (sprot)

description: A general transcription factor 3C polypeptide 1 that is encoded in the genome of human.


tRNA transcription

description: The synthesis of transfer RNA (tRNA) from a DNA template.


name: 5S class rRNA transcription by RNA polymerase III

description: The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter.


transcription factor TFIIIC complex

description: A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions.


name: KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (sprot)

description: A calcium-activated potassium channel subunit alpha-1 that is encoded in the genome of human.


name: large conductance calcium-activated potassium channel activity

description: Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.


TWF1_HUMAN Twinfilin-1 (sprot)

A twinfilin-1 that is encoded in the genome of human.


regulation of actin phosphorylation

description: Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule.


HYAL1_HUMAN Hyaluronidase-1 (sprot)

A hyaluronidase-1 that is encoded in the genome of human.


chondroitin hydrolase activity

description: Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-].


name: PNRC1_HUMAN Proline-rich nuclear receptor coactivator 1 (sprot)

description: A proline-rich nuclear receptor coactivator 1 that is encoded in the genome of human.


name: ASPH_HUMAN Aspartyl/asparaginyl beta-hydroxylase (sprot)

description: An aspartyl/asparaginyl beta-hydroxylase that is encoded in the genome of human.


name: peptidyl-aspartic acid 3-dioxygenase activity

description: Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2.


regulation of protein depolymerization

description: Any process that modulates the frequency, rate or extent of protein depolymerization.


CETN1_HUMAN Centrin-1 (sprot)

A centrin-1 that is encoded in the genome of human.


name: TFCP2_HUMAN Alpha-globin transcription factor CP2 (sprot)

description: An alpha-globin transcription factor CP2 that is encoded in the genome of human.


name: AKP13_HUMAN A-kinase anchor protein 13 (sprot)

description: An A-kinase anchor protein 13 that is encoded in the genome of human.


regulation of sarcomere organization

description: Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


name: FBLN3_HUMAN EGF-containing fibulin-like extracellular matrix protein 1 (sprot)

description: An EGF-containing fibulin-like extracellular matrix protein 1 that is encoded in the genome of human.


name: KCNH2_HUMAN Potassium voltage-gated channel subfamily H member 2 (sprot)

description: A voltage-gated potassium channel KCNH2 that is encoded in the genome of human.


name: negative regulation of potassium ion export across plasma membrane

description: Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export across the plasma membrane.


TROAP_HUMAN Tastin (sprot)

A trophinin-associated protein that is encoded in the genome of human.


TROP_HUMAN Trophinin (sprot)

A trophinin that is encoded in the genome of human.


name: SNF5_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (sprot)

description: A SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 that is encoded in the genome of human.


name: single stranded viral RNA replication via double stranded DNA intermediate

description: A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II.


name: RB40B_HUMAN Ras-related protein Rab-40B (sprot)

description: A Ras-related protein Rab-40B that is encoded in the genome of human.


name: BPTF_HUMAN Nucleosome-remodeling factor subunit BPTF (sprot)

description: A nucleosome-remodeling factor subunit BPTF that is encoded in the genome of human.


name: CDC20_HUMAN Cell division cycle protein 20 homolog (sprot)

description: A cell division cycle protein 20 homolog that is encoded in the genome of human.


name: metaphase/anaphase transition of cell cycle

description: The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle.


name: metaphase/anaphase transition of meiosis I

description: The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis I.


name: ZP4_HUMAN Zona pellucida sperm-binding protein 4 (sprot)

description: A zona pellucida sperm-binding protein 4 that is encoded in the genome of human.


name: PO4F2_HUMAN POU domain, class 4, transcription factor 2 (sprot)

description: A POU domain, class 4, transcription factor 2 that is encoded in the genome of human.


name: regulation of retinal ganglion cell axon guidance

description: Any process that modulates the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.


name: KIF5A_HUMAN Kinesin heavy chain isoform 5A (sprot)

description: A kinesin heavy chain isoform 5A that is encoded in the genome of human.


name: FSTL1_HUMAN Follistatin-related protein 1 (sprot)

description: A follistatin-related protein 1 that is encoded in the genome of human.


STX4_HUMAN Syntaxin-4 (sprot)

A syntaxin-4 that is encoded in the genome of human.


name: sphingomyelin phosphodiesterase activator activity

description: Binds to and increases the activity of the enzyme sphingomyelin phosphodiesterase.


organelle fusion

description: The creation of a single organelle from two or more organelles.


neuron projection membrane

description: The portion of the plasma membrane surrounding a neuron projection.


lateral loop

description: Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode.


name: GRSF1_HUMAN G-rich sequence factor 1 (sprot)

description: A G-rich sequence factor 1 that is encoded in the genome of human.


name: positive regulation of mitochondrial RNA catabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.


name: M4K2_HUMAN Mitogen-activated protein kinase kinase kinase kinase 2 (sprot)

description: A mitogen-activated protein kinase kinase kinase kinase 2 that is encoded in the genome of human.


name: M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 (sprot)

description: A mitogen-activated protein kinase kinase kinase 12 that is encoded in the genome of human.


name: NFIA_HUMAN Nuclear factor 1 A-type (sprot)

description: A nuclear factor 1 A-type that is encoded in the genome of human.


CNTN1_HUMAN Contactin-1 (sprot)

A contactin-1 that is encoded in the genome of human.


CAD17_HUMAN Cadherin-17 (sprot)

A cadherin-17 that is encoded in the genome of human.


oligopeptide transport

description: The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


name: positive regulation of integrin activation by cell surface receptor linked signal transduction

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that activates or increases the frequency, rate, or extent of integrin activation by cell surface receptor linked signal transduction. This can occur by increased affinity of an integrin for its extracellular ligands.


oligopeptide transmembrane transport

description: The process in which an oligopeptide is transported across a membrane. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


name: MERTK_HUMAN Tyrosine-protein kinase Mer (sprot)

description: A tyrosine-protein kinase Mer that is encoded in the genome of human.


name: TCF15_HUMAN Transcription factor 15 (sprot)

description: A transcription factor 15 that is encoded in the genome of human.


name: SFSWA_HUMAN Splicing factor, suppressor of white-apricot homolog (sprot)

description: A splicing factor, arginine/serine-rich 8 that is encoded in the genome of human.


name: CHD3_HUMAN Chromodomain-helicase-DNA-binding protein 3 (sprot)

description: A chromodomain-helicase-DNA-binding protein 3 that is encoded in the genome of human.


name: SF3A3_HUMAN Splicing factor 3A subunit 3 (sprot)

description: A splicing factor 3A subunit 3 that is encoded in the genome of human.


name: NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (sprot)

description: A glutamate receptor ionotropic, NMDA 2A that is encoded in the genome of human.


sleep

description: Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.


directional locomotion

description: Self-propelled movement of a cell or organism from one location to another along an axis.


name: protein localization to postsynaptic membrane

description: A process in which a protein is transported to, or maintained in, a location within a postsynaptic membrane.


name: DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP(+)] (sprot)

description: A dihydropyrimidine dehydrogenase [NADP(+)] that is encoded in the genome of human.


name: dihydropyrimidine dehydrogenase (NADP+) activity

description: Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+.


purine nucleobase catabolic process

description: The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.


pyrimidine nucleobase catabolic process

description: The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.


uracil catabolic process

description: The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.


thymidine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.


CMP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate.


beta-alanine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.


UMP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate.


dUMP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate.


name: SEPR_HUMAN Prolyl endopeptidase FAP (sprot)

description: A prolyl endopeptidase FAP that is encoded in the genome of human.


name: negative regulation of extracellular matrix organization

description: Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization.


peptidase complex

description: A protein complex which is capable of peptidase activity.


name: COX10_HUMAN Protoheme IX farnesyltransferase, mitochondrial (sprot)

description: A protoheme IX farnesyltransferase, mitochondrial that is encoded in the genome of human.


name: protoheme IX farnesyltransferase activity

description: Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate.


name: TP53B_HUMAN TP53-binding protein 1 (sprot)

description: A TP53-binding protein 1 that is encoded in the genome of human.


name: ubiquitin-modified histone reader activity

description: A molecular adaptor that recognizes and binds a histone protein containing a ubiquitination modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.


name: OVGP1_HUMAN Oviduct-specific glycoprotein (sprot)

description: An oviduct-specific glycoprotein that is encoded in the genome of human.


perivitelline space

description: The space between the membrane of an oocyte and a surrounding membranous structure (zona pellucida or perivitelline membrane).


HYAL2_HUMAN Hyaluronidase-2 (sprot)

A hyaluronidase-2 that is encoded in the genome of human.


name: receptor signaling protein tyrosine kinase inhibitor activity

description: Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase.


name: TM115_HUMAN Transmembrane protein 115 (sprot)

description: A transmembrane protein 115 that is encoded in the genome of human.


name: IFRD2_HUMAN Interferon-related developmental regulator 2 (sprot)

description: An interferon-related developmental regulator 2 that is encoded in the genome of human.


name: TRI26_HUMAN Tripartite motif-containing protein 26 (sprot)

description: A tripartite motif-containing protein 26 that is encoded in the genome of human.


name: ZN155_HUMAN Zinc finger protein 155 (sprot)

description: A zinc finger protein 155 that is encoded in the genome of human.


name: AIMP1_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (sprot)

description: An aminoacyl tRNA synthase complex-interacting multifunctional protein 1 that is encoded in the genome of human.


name: positive regulation of glucagon secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.


name: ILF2_HUMAN Interleukin enhancer-binding factor 2 (sprot)

description: An interleukin enhancer-binding factor 2 that is encoded in the genome of human.


name: ILF3_HUMAN Interleukin enhancer-binding factor 3 (sprot)

description: An interleukin enhancer-binding factor 3 that is encoded in the genome of human.


name: LMAN2_HUMAN Vesicular integral-membrane protein VIP36 (sprot)

description: A vesicular integral-membrane protein VIP36 that is encoded in the genome of human.


name: NTCP2_HUMAN Ileal sodium/bile acid cotransporter (sprot)

description: An ileal sodium/bile acid cotransporter that is encoded in the genome of human.


bile acid:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in).


name: IRAG2_HUMAN Inositol 1,4,5-triphosphate receptor associated 2 (sprot)

description: An inositol 1,4,5-triphosphate receptor associated 2 that is encoded in the genome of human.


name: PTPRJ_HUMAN Receptor-type tyrosine-protein phosphatase eta (sprot)

description: A receptor-type tyrosine-protein phosphatase eta that is encoded in the genome of human.


name: KLRB1_HUMAN Killer cell lectin-like receptor subfamily B member 1 (sprot)

description: A killer cell lectin-like receptor subfamily B member 1 that is encoded in the genome of human.


name: PTN13_HUMAN Tyrosine-protein phosphatase non-receptor type 13 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 13 that is encoded in the genome of human.


name: negative regulation of excitatory synapse assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse assembly.


ELAV2_HUMAN ELAV-like protein 2 (sprot)

An ELAV-like protein 2 that is encoded in the genome of human.


name: EPS8_HUMAN Epidermal growth factor receptor kinase substrate 8 (sprot)

description: An epidermal growth factor receptor kinase substrate 8 that is encoded in the genome of human.


name: TRAP1_HUMAN Heat shock protein 75 kDa, mitochondrial (sprot)

description: A heat shock protein 75 kDa, mitochondrial that is encoded in the genome of human.


translational attenuation

description: Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation.


name: negative regulation of cellular respiration

description: Any process that stops, prevents or reduces the frequency, rate or extent of cellular respiration.


name: TRAF2_HUMAN TNF receptor-associated factor 2 (sprot)

description: A TNF receptor-associated factor 2 that is encoded in the genome of human.


programmed necrotic cell death

description: A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.


BFSP1_HUMAN Filensin (sprot)

A filensin that is encoded in the genome of human.


name: FOXF1_HUMAN Forkhead box protein F1 (sprot)

description: A forkhead box protein F1 that is encoded in the genome of human.


detection of wounding

description: The series of events by which an injury stimulus is received and converted into a molecular signal.


respiratory tube development

description: The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.


lateral mesodermal cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a lateral mesoderm cell.


name: embryonic ectodermal digestive tract morphogenesis

description: The process, occurring during the embryonic phase, by which the anatomical structures of the ectodermal digestive tract are generated and organized.


right lung morphogenesis

description: The process in which anatomical structures of the right lung are generated and organized.


name: FOXF2_HUMAN Forkhead box protein F2 (sprot)

description: A forkhead box protein F2 that is encoded in the genome of human.


name: regulation of protein polyubiquitination

description: Any process that modulates the frequency, rate or extent of protein polyubiquitination.


name: FOXC1_HUMAN Forkhead box protein C1 (sprot)

description: A forkhead box protein C1 that is encoded in the genome of human.


name: apoptotic process involved in outflow tract morphogenesis

description: Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries.


glomerular epithelium development

description: The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros.


name: positive regulation of hematopoietic stem cell differentiation

description: Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation.


name: negative regulation of apoptotic process involved in outflow tract morphogenesis

description: Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.


name: FOXD4_HUMAN Forkhead box protein D4 (sprot)

description: A forkhead box protein D4 that is encoded in the genome of human.


name: FOXI1_HUMAN Forkhead box protein I1 (sprot)

description: A forkhead box protein I1 that is encoded in the genome of human.


name: FOXL1_HUMAN Forkhead box protein L1 (sprot)

description: A forkhead box protein L1 that is encoded in the genome of human.


name: visceral mesoderm-endoderm interaction involved in midgut development

description: The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut.


ANK3_HUMAN Ankyrin-3 (sprot)

An ankyrin-3 that is encoded in the genome of human.


name: positive regulation of cell communication by electrical coupling

description: Any process that increases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.


name: maintenance of protein location in plasma membrane

description: Any process in which a protein is maintained in a specific location in the plasma membrane, and is prevented from moving elsewhere.


name: positive regulation of membrane depolarization during cardiac muscle cell action potential

description: Any process that activates or increases the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential.


name: DLG1_HUMAN Disks large homolog 1 (sprot)

description: A disks large homolog 1 that is encoded in the genome of human.


name: structural constituent of postsynaptic density

description: The action of a molecule that contributes to the structural integrity of a postsynaptic density.


name: regulation of protein localization to synapse

description: Any process that modulates the frequency, rate or extent of protein localization to synapse.


regulation of potassium ion import

description: Any process that modulates the frequency, rate or extent of potassium ion import.


name: regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

description: Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization.


name: regulation of potassium ion export across plasma membrane

description: Any process that modulates the frequency, rate or extent of potassium ion export across the plasma membrane.


MPP7-DLG1-LIN7 complex

description: A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions.


name: TAF10_HUMAN Transcription initiation factor TFIID subunit 10 (sprot)

description: A transcription initiation factor TFIID subunit 10 that is encoded in the genome of human.


SAGA complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof.


name: MYO1E_HUMAN Unconventional myosin-Ie (sprot)

description: A myosin-Ie that is encoded in the genome of human.


name: GNDS_HUMAN Ral guanine nucleotide dissociation stimulator (sprot)

description: A Ral guanine nucleotide dissociation stimulator that is encoded in the genome of human.


name: NFAC3_HUMAN Nuclear factor of activated T-cells, cytoplasmic 3 (sprot)

description: A nuclear factor of activated T-cells, cytoplasmic 3 that is encoded in the genome of human.


name: PP1R8_HUMAN Nuclear inhibitor of protein phosphatase 1 (sprot)

description: A nuclear inhibitor of protein phosphatase 1 that is encoded in the genome of human.


ribonuclease E activity

description: Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group.


name: TP4A2_HUMAN Protein tyrosine phosphatase type IVA 2 (sprot)

description: A protein tyrosine phosphatase type IVA 2 that is encoded in the genome of human.


name: ABR_HUMAN Active breakpoint cluster region-related protein (sprot)

description: An active breakpoint cluster region-related protein that is encoded in the genome of human.


name: NPRL3_HUMAN GATOR1 complex protein NPRL3 (sprot)

description: A GATOR1 complex protein NPRL3 that is encoded in the genome of human.


name: SEC20_HUMAN Vesicle transport protein SEC20 (sprot)

description: A vesicle transport protein SEC20 that is encoded in the genome of human.


endoplasmic reticulum membrane fusion

description: The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum.


name: apoptotic process in response to mitochondrial fragmentation

description: Any apoptotic process that occurs as a result of mitochondrial fragmentation.


name: BNIP2_HUMAN BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (sprot)

description: A BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 that is encoded in the genome of human.


name: BNIP3_HUMAN BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (sprot)

description: A BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 that is encoded in the genome of human.


name: negative regulation of membrane potential

description: Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


name: positive regulation of autophagy of mitochondrion

description: Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy.


name: NFX1_HUMAN Transcriptional repressor NF-X1 (sprot)

description: A transcriptional repressor NF-X1 that is encoded in the genome of human.


name: HSPB3_HUMAN Heat shock protein beta-3 (sprot)

description: A heat shock protein beta-3 that is encoded in the genome of human.


name: CSTF3_HUMAN Cleavage stimulation factor subunit 3 (sprot)

description: A cleavage stimulation factor subunit 3 that is encoded in the genome of human.


name: mRNA cleavage stimulating factor complex

description: A protein complex required for mRNA cleavage but not for poly(A) addition.


TSN31_HUMAN Tetraspanin-31 (sprot)

A tetraspanin-31 that is encoded in the genome of human.


name: GRIK2_HUMAN Glutamate receptor ionotropic, kainate 2 (sprot)

description: A glutamate receptor ionotropic, kainate 2 that is encoded in the genome of human.


name: extracellularly glutamate-gated ion channel activity

description: Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.


name: detection of cold stimulus involved in thermoception

description: The series of events in which a cold stimulus is received and converted into a molecular signal as part of thermoception.


mossy fiber rosette

description: A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes.


name: GRIK3_HUMAN Glutamate receptor ionotropic, kainate 3 (sprot)

description: A glutamate receptor ionotropic, kainate 3 that is encoded in the genome of human.


name: adenylate cyclase inhibiting G protein-coupled glutamate receptor activity

description: Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity.


IL24_HUMAN Interleukin-24 (sprot)

An interleukin-24 that is encoded in the genome of human.


name: TIAM1_HUMAN Rho guanine nucleotide exchange factor TIAM1 (sprot)

description: A Rho guanine nucleotide exchange factor TIAM1 that is encoded in the genome of human.


name: positive regulation of Schwann cell chemotaxis

description: Any process that activates or increases the frequency, rate or extent of Schwann cell chemotaxis.


name: extrinsic component of postsynaptic density membrane

description: The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


name: ECH1_HUMAN Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (sprot)

description: A Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial that is encoded in the genome of human.


AF1Q_HUMAN Protein AF1q (sprot)

A protein AF1q that is encoded in the genome of human.


name: RHG05_HUMAN Rho GTPase-activating protein 5 (sprot)

description: A Rho GTPase-activating protein 5 that is encoded in the genome of human.


name: PLA2R_HUMAN Secretory phospholipase A2 receptor (sprot)

description: A secretory phospholipase A2 receptor that is encoded in the genome of human.


name: negative regulation of arachidonic acid secretion

description: Any process that stops, prevents or reduces the frequency, rate or extent of arachidonic acid secretion.


MALL_HUMAN MAL-like protein (sprot)

A MAL-like protein that is encoded in the genome of human.


name: AKAP6_HUMAN A-kinase anchor protein 6 (sprot)

description: An A-kinase anchor protein 6 that is encoded in the genome of human.


name: PRDM2_HUMAN PR domain zinc finger protein 2 (sprot)

description: A PR domain zinc finger protein 2 that is encoded in the genome of human.


STRN3_HUMAN Striatin-3 (sprot)

A striatin-3 that is encoded in the genome of human.


name: CDC16_HUMAN Cell division cycle protein 16 homolog (sprot)

description: A cell division cycle protein 16 that is encoded in the genome of human.


name: STK4_HUMAN Serine/threonine-protein kinase 4 (sprot)

description: A serine/threonine-protein kinase 4 that is encoded in the genome of human.


neural tube formation

description: The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.


primitive hemopoiesis

description: A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells.


name: regulation of cell differentiation involved in embryonic placenta development

description: Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state.


name: positive regulation of hepatocyte apoptotic process

description: Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process.


name: FLII_HUMAN Protein flightless-1 homolog (sprot)

description: A protein flightless-1 that is encoded in the genome of human.


name: PSG7_HUMAN Pregnancy-specific beta-1-glycoprotein 7 (sprot)

description: A pregnancy-specific beta-1-glycoprotein 7 that is encoded in the genome of human.


name: TRI32_HUMAN E3 ubiquitin-protein ligase TRIM32 (sprot)

description: An E3 ubiquitin-protein ligase TRIM32 that is encoded in the genome of human.


actin ubiquitination

description: The modification of actin by addition of ubiquitin groups.


name: positive regulation of interleukin-17-mediated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of interleukin-17-mediated signaling pathway.


name: positive regulation of chemokine (C-C motif) ligand 20 production

description: Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 20 production.


name: COASY_HUMAN Bifunctional coenzyme A synthase (sprot)

description: A bifunctional coenzyme A synthase that is encoded in the genome of human.


dephospho-CoA kinase activity

description: Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+.


description: Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate.


TRDN_HUMAN Triadin (sprot)

A triadin that is encoded in the genome of human.


name: positive regulation of cell communication by electrical coupling involved in cardiac conduction

description: Any process that activates or increases the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction.


junctional membrane complex

description: Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules).


name: MKRN3_HUMAN Probable E3 ubiquitin-protein ligase makorin-3 (sprot)

description: A makorin-3 that is encoded in the genome of human.


GAG2B_HUMAN G antigen 2B/2C (sprot)

A G antigen 2B/2C that is encoded in the genome of human.


GAGE5_HUMAN G antigen 5 (sprot)

A G antigen 5 that is encoded in the genome of human.


name: BAGE1_HUMAN B melanoma antigen 1 (sprot)

description: A B melanoma antigen 1 that is encoded in the genome of human.


name: BIRC1_HUMAN Baculoviral IAP repeat-containing protein 1 (sprot)

description: A baculoviral IAP repeat-containing protein 1 that is encoded in the genome of human.


name: TRAF1_HUMAN TNF receptor-associated factor 1 (sprot)

description: A TNF receptor-associated factor 1 that is encoded in the genome of human.


name: RM28_HUMAN Large ribosomal subunit protein bL28m (sprot)

description: A large ribosomal subunit protein bL28m that is encoded in the genome of human.


name: ACACA_HUMAN Acetyl-CoA carboxylase 1 (sprot)

description: An acetyl-CoA carboxylase 1 that is encoded in the genome of human.


name: PDIA2_HUMAN Protein disulfide-isomerase A2 (sprot)

description: A protein disulfide-isomerase A2 that is encoded in the genome of human.


name: PAFA_HUMAN Platelet-activating factor acetylhydrolase (sprot)

description: A platelet-activating factor acetylhydrolase that is encoded in the genome of human.


lipid oxidation

description: The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.


plasma lipoprotein particle oxidation

description: The modification of a lipid or protein within a plasma lipoprotein particle by oxidation of the lipid or one or more amino acids.


name: LCP2_HUMAN Lymphocyte cytosolic protein 2 (sprot)

description: A lymphocyte cytosolic protein 2 that is encoded in the genome of human.


name: CSN1_HUMAN COP9 signalosome complex subunit 1 (sprot)

description: A COP9 signalosome complex subunit 1 that is encoded in the genome of human.


name: IFT88_HUMAN Intraflagellar transport protein 88 homolog (sprot)

description: An intraflagellar transport protein 88 that is encoded in the genome of human.


name: SPP24_HUMAN Secreted phosphoprotein 24 (sprot)

description: A secreted phosphoprotein 24 that is encoded in the genome of human.


name: ZBT17_HUMAN Zinc finger and BTB domain-containing protein 17 (sprot)

description: A zinc finger and BTB domain-containing protein 17 that is encoded in the genome of human.


name: ZN154_HUMAN Zinc finger protein 154 (sprot)

description: A zinc finger protein 154 that is encoded in the genome of human.


name: UBP4_HUMAN Ubiquitin carboxyl-terminal hydrolase 4 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 4 that is encoded in the genome of human.


adenosine receptor binding

description: Binding to an adenosine receptor.


name: CAF1A_HUMAN Chromatin assembly factor 1 subunit A (sprot)

description: A chromatin assembly factor 1 subunit A that is encoded in the genome of human.


name: CAF1B_HUMAN Chromatin assembly factor 1 subunit B (sprot)

description: A chromatin assembly factor 1 subunit B that is encoded in the genome of human.


name: PDZ1I_HUMAN PDZK1-interacting protein 1 (sprot)

description: A PDZK1-interacting protein 1 that is encoded in the genome of human.


name: TRAF3_HUMAN TNF receptor-associated factor 3 (sprot)

description: A TNF receptor-associated factor 3 that is encoded in the genome of human.


name: DUS4_HUMAN Dual specificity protein phosphatase 4 (sprot)

description: A dual specificity protein phosphatase 4 that is encoded in the genome of human.


name: protein tyrosine/threonine phosphatase activity

description: Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


name: MAP kinase serine/threonine phosphatase activity

description: Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate.


name: DAZ2_HUMAN Deleted in azoospermia protein 2 (sprot)

description: A deleted in azoospermia protein 2 that is encoded in the genome of human.


name: KLF10_HUMAN Krueppel-like factor 10 (sprot)

description: A krueppel-like factor 10 that is encoded in the genome of human.


RED_HUMAN Protein Red (sprot)

A protein Red that is encoded in the genome of human.


name: MTAP_HUMAN S-methyl-5'-thioadenosine phosphorylase (sprot)

description: An S-methyl-5'-thioadenosine phosphorylase that is encoded in the genome of human.


name: L-methionine salvage from methylthioadenosine

description: The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.


name: REST_HUMAN RE1-silencing transcription factor (sprot)

description: An RE1-silencing transcription factor that is encoded in the genome of human.


name: negative regulation of dense core granule biogenesis

description: Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule biogenesis.


name: negative regulation of amniotic stem cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of amniotic stem cell differentiation.


name: RLF_HUMAN Zinc finger protein Rlf (sprot)

description: A zinc finger protein Rlf that is encoded in the genome of human.


name: AAPK1_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-1 (sprot)

description: A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that is encoded in the genome of human.


cold acclimation

description: Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.


name: negative regulation of glucosylceramide biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide.


name: positive regulation of mitochondrial transcription

description: Any process that activates or increases the frequency, rate or extent of transcription occurring in the mitochondrion.


name: NR1H3_HUMAN Oxysterols receptor LXR-alpha (sprot)

description: An oxysterols receptor LXR-alpha that is encoded in the genome of human.


name: negative regulation of pancreatic juice secretion

description: Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine.


name: negative regulation of secretion of lysosomal enzymes

description: Any process that decreases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell.


LIPA1_HUMAN Liprin-alpha-1 (sprot)

A liprin-alpha-1 that is encoded in the genome of human.


name: CACO2_HUMAN Calcium-binding and coiled-coil domain-containing protein 2 (sprot)

description: A calcium-binding and coiled-coil domain-containing protein 2 that is encoded in the genome of human.


name: EI2BE_HUMAN Translation initiation factor eIF2B subunit epsilon (sprot)

description: A translation initiation factor eIF2B subunit epsilon that is encoded in the genome of human.


name: BAMBI_HUMAN BMP and activin membrane-bound inhibitor homolog (sprot)

description: A BMP and activin membrane-bound inhibitor that is encoded in the genome of human.


name: TADBP_HUMAN TAR DNA-binding protein 43 (sprot)

description: A TAR DNA-binding protein 43 that is encoded in the genome of human.


nuclear inner membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner membrane.


name: ROA0_HUMAN Heterogeneous nuclear ribonucleoprotein A0 (sprot)

description: A heterogeneous nuclear ribonucleoprotein A0 that is encoded in the genome of human.


name: PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (sprot)

description: A serine/threonine-protein kinase PAK 1 that is encoded in the genome of human.


name: AIMP2_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (sprot)

description: An aminoacyl tRNA synthase complex-interacting multifunctional protein 2 that is encoded in the genome of human.


name: RFA4_HUMAN Replication protein A 30 kDa subunit (sprot)

description: A replication protein A 30 kDa subunit that is encoded in the genome of human.


nuclear DNA replication

description: The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.


name: FADD_HUMAN FAS-associated death domain protein (sprot)

description: A FAS-associated death domain protein that is encoded in the genome of human.


death effector domain binding

description: Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD).


name: negative regulation of activation-induced cell death of T cells

description: Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells.


name: positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation

description: Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation.


PRDX4_HUMAN Peroxiredoxin-4 (sprot)

A peroxiredoxin-4 that is encoded in the genome of human.


name: MP2K5_HUMAN Dual specificity mitogen-activated protein kinase kinase 5 (sprot)

description: A dual specificity mitogen-activated protein kinase kinase 5 that is encoded in the genome of human.


name: MK07_HUMAN Mitogen-activated protein kinase 7 (sprot)

description: A mitogen-activated protein kinase 7 that is encoded in the genome of human.


name: CATR1_HUMAN CATR tumorigenic conversion 1 protein (sprot)

description: A CATR tumorigenic conversion 1 protein that is encoded in the genome of human.


name: PAK2_HUMAN Serine/threonine-protein kinase PAK 2 (sprot)

description: A serine/threonine-protein kinase PAK 2 that is encoded in the genome of human.


name: negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

description: Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis.


name: S13A2_HUMAN Solute carrier family 13 member 2 (sprot)

description: A solute carrier family 13 member 2 that is encoded in the genome of human.


name: fumarate transmembrane transporter activity

description: Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate.


name: alpha-ketoglutarate transmembrane transporter activity

description: Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle.


name: low-affinity sodium:dicarboxylate symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.


name: sodium:dicarboxylate symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in).


fumarate transport

description: The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: CBX3_HUMAN Chromobox protein homolog 3 (sprot)

description: A chromobox protein homolog 3 that is encoded in the genome of human.


name: STK3_HUMAN Serine/threonine-protein kinase 3 (sprot)

description: A serine/threonine-protein kinase 3 that is encoded in the genome of human.


STX5_HUMAN Syntaxin-5 (sprot)

A syntaxin-5 that is encoded in the genome of human.


name: CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B (sprot)

description: An E3 ubiquitin-protein ligase CBL-B that is encoded in the genome of human.


name: PSMD2_HUMAN 26S proteasome non-ATPase regulatory subunit 2 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 2 that is encoded in the genome of human.


MMRN1_HUMAN Multimerin-1 (sprot)

A multimerin-1 that is encoded in the genome of human.


multimerin complex

description: Glycoprotein complex of the C1q/TNF superfamily involved in cell adhesion. A homotrimer that will combine to form supramolecular Multimerin structures.


name: DUS8_HUMAN Dual specificity protein phosphatase 8 (sprot)

description: A dual specificity protein phosphatase 8 that is encoded in the genome of human.


name: MYBPH_HUMAN Myosin-binding protein H (sprot)

description: A myosin-binding protein H that is encoded in the genome of human.


name: DDX10_HUMAN Probable ATP-dependent RNA helicase DDX10 (sprot)

description: A probable ATP-dependent RNA helicase DDX10 that is encoded in the genome of human.


name: TBX2_HUMAN T-box transcription factor TBX2 (sprot)

description: A T-box transcription factor TBX2 that is encoded in the genome of human.


name: pigment metabolic process involved in pigmentation

description: The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell.


negative regulation of heart looping

description: Any process that stops, prevents or reduces the frequency, rate or extent of heart looping.


name: negative regulation of cardiac chamber formation

description: Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation.


SEM3B_HUMAN Semaphorin-3B (sprot)

A semaphorin-3B that is encoded in the genome of human.


name: ERCC8_HUMAN DNA excision repair protein ERCC-8 (sprot)

description: A DNA excision repair protein ERCC-8 that is encoded in the genome of human.


name: regulation of transcription-coupled nucleotide-excision repair

description: Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.


name: DNJC3_HUMAN DnaJ homolog subfamily C member 3 (sprot)

description: A DnaJ homolog subfamily C member 3 that is encoded in the genome of human.


name: positive regulation of translation initiation in response to endoplasmic reticulum stress

description: Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.


PAPP1_HUMAN Pappalysin-1 (sprot)

A pappalysin-1 that is encoded in the genome of human.


name: NMDE2_HUMAN Glutamate receptor ionotropic, NMDA 2B (sprot)

description: A glutamate receptor ionotropic, NMDA 2B that is encoded in the genome of human.


name: GPS2_HUMAN G protein pathway suppressor 2 (sprot)

description: A G protein pathway suppressor 2 that is encoded in the genome of human.


name: negative regulation of protein K63-linked ubiquitination

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked ubiquitination.


SBP1_HUMAN Methanethiol oxidase (sprot)

A methanethiol oxidase that is encoded in the genome of human.


methanethiol oxidase activity

description: Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide.


CHIT1_HUMAN Chitotriosidase-1 (sprot)

A chitotriosidase-1 that is encoded in the genome of human.


endochitinase activity

description: Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain.


polysaccharide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.


chitin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.


name: NDK3_HUMAN Nucleoside diphosphate kinase 3 (sprot)

description: A nucleoside diphosphate kinase 3 that is encoded in the genome of human.


name: M3K1_HUMAN Mitogen-activated protein kinase kinase kinase 1 (sprot)

description: A mitogen-activated protein kinase kinase kinase 1 that is encoded in the genome of human.


name: KGP2_HUMAN cGMP-dependent protein kinase 2 (sprot)

description: A cGMP-dependent protein kinase 2 that is encoded in the genome of human.


cGMP-dependent protein kinase activity

description: cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


tetrahydrobiopterin metabolic process

description: The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.


SLAP1_HUMAN Src-like-adapter (sprot)

A Src-like-adapter that is encoded in the genome of human.


name: KLRD1_HUMAN Natural killer cells antigen CD94 (sprot)

description: A killer cell lectin-like receptor subfamily D member 1 that is encoded in the genome of human.


name: MHC class Ib protein binding, via antigen binding groove

description: Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove.


name: SRSF9_HUMAN Serine/arginine-rich splicing factor 9 (sprot)

description: A serine/arginine-rich splicing factor 9 that is encoded in the genome of human.


name: SRSF5_HUMAN Serine/arginine-rich splicing factor 5 (sprot)

description: A serine/arginine-rich splicing factor 5 that is encoded in the genome of human.


name: SRSF6_HUMAN Serine/arginine-rich splicing factor 6 (sprot)

description: A serine/arginine-rich splicing factor 6 that is encoded in the genome of human.


NOGG_HUMAN Noggin (sprot)

A noggin that is encoded in the genome of human.


name: negative regulation of cardiac epithelial to mesenchymal transition

description: Any process that stops or decreases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


name: GRM1_HUMAN Metabotropic glutamate receptor 1 (sprot)

description: A metabotropic glutamate receptor 1 that is encoded in the genome of human.


name: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

description: A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse.


name: G protein-coupled receptor dimeric complex

description: A protein complex that contains two G protein-coupled receptors.


name: G protein-coupled receptor homodimeric complex

description: A protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor.


name: MD2L1_HUMAN Mitotic spindle assembly checkpoint protein MAD2A (sprot)

description: A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of human.


name: mitotic spindle assembly checkpoint MAD1-MAD2 complex

description: A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex.


name: PD2R_HUMAN Prostaglandin D2 receptor (sprot)

description: A prostaglandin D2 receptor that is encoded in the genome of human.


prostaglandin J receptor activity

description: Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.


prostaglandin D receptor activity

description: Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity.


name: I15RA_HUMAN Interleukin-15 receptor subunit alpha (sprot)

description: An interleukin-15 receptor subunit alpha that is encoded in the genome of human.


name: TIF1B_HUMAN Transcription intermediary factor 1-beta (sprot)

description: A transcription intermediary factor 1-beta that is encoded in the genome of human.


Krueppel-associated box domain binding

description: Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors.


name: positive regulation of DNA methylation-dependent heterochromatin formation

description: Any process that increases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation.


name: DHRS2_HUMAN Dehydrogenase/reductase SDR family member 2, mitochondrial (sprot)

description: A dehydrogenase/reductase SDR family member 2, mitochondrial that is encoded in the genome of human.


SEM3F_HUMAN Semaphorin-3F (sprot)

A semaphorin-3F that is encoded in the genome of human.


STX3_HUMAN Syntaxin-3 (sprot)

A syntaxin-3 that is encoded in the genome of human.


organelle membrane fusion

description: The joining of two lipid bilayers to form a single organelle membrane.


name: G3BP1_HUMAN Ras GTPase-activating protein-binding protein 1 (sprot)

description: A Ras GTPase-activating protein-binding protein 1 that is encoded in the genome of human.


DNA/RNA helicase activity

description: Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis.


name: STF1_HUMAN Steroidogenic factor 1 (sprot)

description: A steroidogenic factor 1 that is encoded in the genome of human.


primary sex determination

description: The sex determination process that results in the initial specification of sexual status of an individual organism.


CLN3_HUMAN Battenin (sprot)

A battenin that is encoded in the genome of human.


glycolipid transfer activity

description: Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid.


regulation of autophagosome size

description: Any process that modulates the size of the autophagosome.


description: The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.


phagosome-lysosome docking

description: The initial attachment of a phagosome membrane to a lysosome membrane. Docking requires only that the proteins come close enough to interact and adhere.


name: regulation of cellular response to osmotic stress

description: Any process that modulates the frequency, rate or extent of the cellular response to osmotic stress.


name: regulation of arginine biosynthetic process

description: Any process that modulates the frequency, rate or extent of arginine biosynthetic process.


regulation of phagosome maturation

description: Any process that modulates the frequency, rate or extent of phagosome maturation.


NMI_HUMAN N-myc-interactor (sprot)

An N-myc-interactor that is encoded in the genome of human.


name: SLAF1_HUMAN Signaling lymphocytic activation molecule (sprot)

description: A SLAM family member 1 that is encoded in the genome of human.


name: myeloid dendritic cell activation involved in immune response

description: The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


regulation of vesicle fusion

description: Any process that modulates the frequency, rate or extent of vesicle fusion.


SG2A2_HUMAN Mammaglobin-A (sprot)

A mammaglobin-A that is encoded in the genome of human.


name: KCAB2_HUMAN Voltage-gated potassium channel subunit beta-2 (sprot)

description: A voltage-gated potassium channel subunit beta-2 that is encoded in the genome of human.


pinceau fiber

description: Dense plexus formed by the descending collaterals of cerebellar basket cells that wrap around a Purkinje cell axonal initial segment.


name: GPR17_HUMAN Uracil nucleotide/cysteinyl leukotriene receptor (sprot)

description: A uracil nucleotide/cysteinyl leukotriene receptor that is encoded in the genome of human.


name: PTK7_HUMAN Inactive tyrosine-protein kinase 7 (sprot)

description: An inactive tyrosine-protein kinase 7 that is encoded in the genome of human.


axis elongation

description: The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure.


convergent extension

description: The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.


name: SKP2_HUMAN S-phase kinase-associated protein 2 (sprot)

description: An S-phase kinase-associated protein 2 that is encoded in the genome of human.


name: PABP4_HUMAN Polyadenylate-binding protein 4 (sprot)

description: A polyadenylate-binding protein 4 that is encoded in the genome of human.


name: ATM_HUMAN Serine-protein kinase ATM (sprot)

description: A serine-protein kinase ATM that is encoded in the genome of human.


regulation of telomerase activity

description: Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.


cellular response to nitrosative stress

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.


name: establishment of RNA localization to telomere

description: The directed movement of RNA to a specific location in the telomeric region of a chromosome.


name: establishment of protein-containing complex localization to telomere

description: The directed movement of a protein-containing macromolecular complex to a specific location in the telomeric region of a chromosome.


name: positive regulation of DNA catabolic process

description: Any process that activates or increases the frequency, rate or extent of DNA catabolic process.


name: positive regulation of telomerase catalytic core complex assembly

description: Any process that activates or increases the frequency, rate or extent of telomerase catalytic core complex assembly.


name: DMP1_HUMAN Dentin matrix acidic phosphoprotein 1 (sprot)

description: A dentin matrix acidic phosphoprotein 1 that is encoded in the genome of human.


name: CD5R2_HUMAN Cyclin-dependent kinase 5 activator 2 (sprot)

description: A cyclin-dependent kinase 5 activator 2 that is encoded in the genome of human.


superior olivary nucleus maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.


name: GRB10_HUMAN Growth factor receptor-bound protein 10 (sprot)

description: A growth factor receptor-bound protein 10 that is encoded in the genome of human.


name: BIK_HUMAN Bcl-2-interacting killer (sprot)

description: A Bcl-2-interacting killer that is encoded in the genome of human.


name: CRFR2_HUMAN Corticotropin-releasing factor receptor 2 (sprot)

description: A corticotropin-releasing factor receptor 2 that is encoded in the genome of human.


name: IFIT5_HUMAN Interferon-induced protein with tetratricopeptide repeats 5 (sprot)

description: An interferon-induced protein with tetratricopeptide repeats 5 that is encoded in the genome of human.


SGCG_HUMAN Gamma-sarcoglycan (sprot)

A gamma-sarcoglycan that is encoded in the genome of human.


name: MTA1_HUMAN Metastasis-associated protein MTA1 (sprot)

description: A metastasis-associated protein MTA1 that is encoded in the genome of human.


name: PTPRS_HUMAN Receptor-type tyrosine-protein phosphatase S (sprot)

description: A receptor-type tyrosine-protein phosphatase S that is encoded in the genome of human.


trans-synaptic signaling

description: Cell-cell signaling in either direction across the synaptic cleft.


UT1_HUMAN Urea transporter 1 (sprot)

A urea transporter 1 that is encoded in the genome of human.


name: SP140_HUMAN Nuclear body protein SP140 (sprot)

description: A nuclear body protein SP140 that is encoded in the genome of human.


name: EIF3I_HUMAN Eukaryotic translation initiation factor 3 subunit I (sprot)

description: A eukaryotic translation initiation factor 3 subunit I that is encoded in the genome of human.


ITAD_HUMAN Integrin alpha-D (sprot)

An integrin alpha-D that is encoded in the genome of human.


name: KLF1_HUMAN Krueppel-like factor 1 (sprot)

description: A krueppel-like factor 1 that is encoded in the genome of human.


name: CENPR_HUMAN Centromere protein R (sprot)

description: A centromere protein R that is encoded in the genome of human.


name: PPIL2_HUMAN RING-type E3 ubiquitin-protein ligase PPIL2 (sprot)

description: A RING-type E3 ubiquitin-protein ligase PPIL2 that is encoded in the genome of human.


name: ZN177_HUMAN Zinc finger protein 177 (sprot)

description: A zinc finger protein 177 that is encoded in the genome of human.


name: MFAP5_HUMAN Microfibrillar-associated protein 5 (sprot)

description: A microfibrillar-associated protein 5 that is encoded in the genome of human.


name: 2A5G_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (sprot)

description: A serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform that is encoded in the genome of human.


name: CTBP1_HUMAN C-terminal-binding protein 1 (sprot)

description: A C-terminal-binding protein 1 that is encoded in the genome of human.


name: AP3B2_HUMAN AP-3 complex subunit beta-2 (sprot)

description: An AP-3 complex subunit beta-2 that is encoded in the genome of human.


name: MPP3_HUMAN MAGUK p55 subfamily member 3 (sprot)

description: A MAGUK p55 subfamily member 3 that is encoded in the genome of human.


name: PDE3B_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (sprot)

description: A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B that is encoded in the genome of human.


name: cGMP-inhibited cyclic-nucleotide phosphodiesterase activity

description: Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP.


name: PHLP_HUMAN Phosducin-like protein (sprot)

description: A phosducin-like protein that is encoded in the genome of human.


name: JIP2_HUMAN C-Jun-amino-terminal kinase-interacting protein 2 (sprot)

description: A C-Jun-amino-terminal kinase-interacting protein 2 that is encoded in the genome of human.


nonassociative learning

description: A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment.


PLD1_HUMAN Phospholipase D1 (sprot)

A phospholipase D1 that is encoded in the genome of human.


name: MB211_HUMAN Putative nucleotidyltransferase MAB21L1 (sprot)

description: A putative nucleotidyltransferase MAB21L1 that is encoded in the genome of human.


name: TARB1_HUMAN Probable methyltransferase TARBP1 (sprot)

description: A probable methyltransferase TARBP1 that is encoded in the genome of human.


name: ZN211_HUMAN Zinc finger protein 211 (sprot)

description: A zinc finger protein 211 that is encoded in the genome of human.


name: PM2P3_HUMAN Putative postmeiotic segregation increased 2-like protein 3 (sprot)

description: A putative postmeiotic segregation increased 2-like protein 3 that is encoded in the genome of human.


name: MYO7A_HUMAN Unconventional myosin-VIIa (sprot)

description: A myosin-VIIa that is encoded in the genome of human.


pigment granule transport

description: The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


upper tip-link density

description: An electron-dense plaque at the upper end of a stereocilia tip link that provides the anchor in the stereocilia membrane on the side of the stereocilium where the tip link ends.


myosin VII complex

description: A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain.


name: UB2V1_HUMAN Ubiquitin-conjugating enzyme E2 variant 1 (sprot)

description: A ubiquitin-conjugating enzyme E2 variant 1 that is encoded in the genome of human.


name: RM49_HUMAN Large ribosomal subunit protein mL49 (sprot)

description: A large ribosomal subunit protein mL49 that is encoded in the genome of human.


name: DC1I2_HUMAN Cytoplasmic dynein 1 intermediate chain 2 (sprot)

description: A cytoplasmic dynein 1 intermediate chain 2 that is encoded in the genome of human.


name: BT1A1_HUMAN Butyrophilin subfamily 1 member A1 (sprot)

description: A butyrophilin subfamily 1 member A1 that is encoded in the genome of human.


name: ORC1_HUMAN Origin recognition complex subunit 1 (sprot)

description: An origin recognition complex subunit 1 that is encoded in the genome of human.


name: ORC2_HUMAN Origin recognition complex subunit 2 (sprot)

description: An origin recognition complex subunit 2 that is encoded in the genome of human.


name: ILK_HUMAN Integrin-linked protein kinase (sprot)

description: An integrin-linked protein kinase that is encoded in the genome of human.


MSLN_HUMAN Mesothelin (sprot)

A mesothelin that is encoded in the genome of human.


name: IKZF1_HUMAN DNA-binding protein Ikaros (sprot)

description: A DNA-binding protein Ikaros that is encoded in the genome of human.


name: NNTM_HUMAN NAD(P) transhydrogenase, mitochondrial (sprot)

description: An NAD(P) transhydrogenase, mitochondrial that is encoded in the genome of human.


name: NAD(P)+ transhydrogenase (Si-specific) activity

description: Catalysis of the reaction: NADPH + NAD+ = NADP+ + NADH.


SNTA1_HUMAN Alpha-1-syntrophin (sprot)

An alpha-1-syntrophin that is encoded in the genome of human.


name: regulation of vasoconstriction by circulating norepinephrine

description: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream.


SNTB2_HUMAN Beta-2-syntrophin (sprot)

A beta-2-syntrophin that is encoded in the genome of human.


name: XRCC4_HUMAN DNA repair protein XRCC4 (sprot)

description: A DNA repair protein XRCC4 that is encoded in the genome of human.


FHA domain binding

description: Binding to a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich.


positive regulation of ligase activity

description: Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.


name: PPIG_HUMAN Peptidyl-prolyl cis-trans isomerase G (sprot)

description: A peptidyl-prolyl cis-trans isomerase G that is encoded in the genome of human.


TCOF_HUMAN Treacle protein (sprot)

A treacle protein that is encoded in the genome of human.


name: U119A_HUMAN Protein unc-119 homolog A (sprot)

description: A protein unc-119 homolog A that is encoded in the genome of human.


name: negative regulation of clathrin-dependent endocytosis

description: Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-mediated endocytosis.


name: negative regulation of caveolin-mediated endocytosis

description: Any process that stops, prevents or reduces the frequency, rate or extent of caveolin-mediated endocytosis.


name: S39A6_HUMAN Zinc transporter ZIP6 (sprot)

description: A zinc transporter ZIP6 that is encoded in the genome of human.


lymphocyte activation

description: A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.


zinc ion import across plasma membrane

description: The directed movement of zinc(2+) ions from outside of a cell, across the plasma membrane and into the cytosol.


name: MKRN4_HUMAN Putative E3 ubiquitin-protein ligase makorin-4 (sprot)


name: SF3B2_HUMAN Splicing factor 3B subunit 2 (sprot)

description: A splicing factor 3B subunit 2 that is encoded in the genome of human.


OS9_HUMAN Protein OS-9 (sprot)

A protein OS-9 that is encoded in the genome of human.


Hrd1p ubiquitin ligase complex

description: A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78).


name: GOGA4_HUMAN Golgin subfamily A member 4 (sprot)

description: A golgin subfamily A member 4 that is encoded in the genome of human.


name: HAP28_HUMAN 28 kDa heat- and acid-stable phosphoprotein (sprot)

description: A 28 kDa heat- and acid-stable phosphoprotein that is encoded in the genome of human.


name: ADAM9_HUMAN Disintegrin and metalloproteinase domain-containing protein 9 (sprot)

description: A disintegrin and metalloproteinase domain-containing protein 9 that is encoded in the genome of human.


response to antineoplastic agent

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antineoplastic agent stimulus. An antineoplastic agent is a substance that inhibits or prevents the proliferation of neoplasms.


name: ADA15_HUMAN Disintegrin and metalloproteinase domain-containing protein 15 (sprot)

description: A disintegrin and metalloproteinase domain-containing protein 15 that is encoded in the genome of human.


name: TMED1_HUMAN Transmembrane emp24 domain-containing protein 1 (sprot)

description: A transmembrane emp24 domain-containing protein 1 that is encoded in the genome of human.


name: LSAMP_HUMAN Limbic system-associated membrane protein (sprot)

description: A limbic system-associated membrane protein that is encoded in the genome of human.


name: FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP5 that is encoded in the genome of human.


name: TUSC3_HUMAN Tumor suppressor candidate 3 (sprot)

description: A tumor suppressor candidate 3 that is encoded in the genome of human.


name: MYO9B_HUMAN Unconventional myosin-IXb (sprot)

description: A myosin-IXb that is encoded in the genome of human.


name: FOXE3_HUMAN Forkhead box protein E3 (sprot)

description: A forkhead box protein E3 that is encoded in the genome of human.


trabecular meshwork development

description: The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor.


name: ROCK1_HUMAN Rho-associated protein kinase 1 (sprot)

description: A Rho-associated protein kinase 1 that is encoded in the genome of human.


apical constriction

description: The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell.


FZD5_HUMAN Frizzled-5 (sprot)

A frizzled-5 that is encoded in the genome of human.


name: regulation of chorionic trophoblast cell proliferation

description: Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation.


name: NFAC2_HUMAN Nuclear factor of activated T-cells, cytoplasmic 2 (sprot)

description: A nuclear factor of activated T-cells, cytoplasmic 2 that is encoded in the genome of human.


name: TNK1_HUMAN Non-receptor tyrosine-protein kinase TNK1 (sprot)

description: A non-receptor tyrosine-protein kinase TNK1 that is encoded in the genome of human.


name: TOP3A_HUMAN DNA topoisomerase 3-alpha (sprot)

description: A DNA topoisomerase 3-alpha that is encoded in the genome of human.


name: DRP2_HUMAN Dystrophin-related protein 2 (sprot)

description: A dystrophin-related protein 2 that is encoded in the genome of human.


name: MADCA_HUMAN Mucosal addressin cell adhesion molecule 1 (sprot)

description: A mucosal addressin cell adhesion molecule 1 that is encoded in the genome of human.


name: IL18R_HUMAN Interleukin-18 receptor 1 (sprot)

description: An interleukin-18 receptor 1 that is encoded in the genome of human.


name: GAB1_HUMAN GRB2-associated-binding protein 1 (sprot)

description: A GRB2-associated-binding protein 1 that is encoded in the genome of human.


name: SMAD4_HUMAN Mothers against decapentaplegic homolog 4 (sprot)

description: A smad4 that is encoded in the genome of human.


name: positive regulation of cell proliferation involved in heart valve morphogenesis

description: Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.


formation of anatomical boundary

description: The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.


regulation of hair follicle development

description: Any process that modulates the frequency, rate or extent of hair follicle development.


female gonad morphogenesis

description: The process in which a female gonad is generated and organized.


name: negative regulation of cardiac myofibril assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly.


name: SNPC2_HUMAN snRNA-activating protein complex subunit 2 (sprot)

description: An snRNA-activating protein complex subunit 2 that is encoded in the genome of human.


snRNA transcription

description: The synthesis of small nuclear RNA (snRNA) from a DNA template.


name: VPP3_HUMAN V-type proton ATPase 116 kDa subunit a 3 (sprot)

description: A V-type proton ATPase 116 kDa subunit a 3 that is encoded in the genome of human.


response to silver ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus.


dentin mineralization

description: The process in which calcium salts are deposited into the calcareous tooth structure known as dentin.


name: BIRC3_HUMAN Baculoviral IAP repeat-containing protein 3 (sprot)

description: A baculoviral IAP repeat-containing protein 3 that is encoded in the genome of human.


regulation of RIG-I signaling pathway

description: Any process that modulates the frequency, rate or extent of the RIG-I signaling pathway.


name: BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (sprot)

description: A baculoviral IAP repeat-containing protein 2 that is encoded in the genome of human.


name: negative regulation of ripoptosome assembly involved in necroptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process.


name: GPM6B_HUMAN Neuronal membrane glycoprotein M6-b (sprot)

description: A neuronal membrane glycoprotein M6-b that is encoded in the genome of human.


name: PICAL_HUMAN Phosphatidylinositol-binding clathrin assembly protein (sprot)

description: A phosphatidylinositol-binding clathrin assembly protein that is encoded in the genome of human.


membrane bending

description: A membrane organization process resulting in the bending of a membrane.


name: MAMD1_HUMAN Mastermind-like domain-containing protein 1 (sprot)

description: A mastermind-like domain-containing protein 1 that is encoded in the genome of human.


MTM1_HUMAN Myotubularin (sprot)

A myotubularin that is encoded in the genome of human.


regulation of vacuole organization

description: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.


SQSTM_HUMAN Sequestosome-1 (sprot)

A sequestosome-1 that is encoded in the genome of human.


name: K63-linked polyubiquitin modification-dependent protein binding

description: Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein.


aggrephagy

description: The selective degradation of protein aggregates by macroautophagy.


amphisome

description: Intermediate organelles formed during macroautophagy through the fusion between autophagosomes and endosomes.


name: MED21_HUMAN Mediator of RNA polymerase II transcription subunit 21 (sprot)

description: A mediator of RNA polymerase II transcription subunit 21 that is encoded in the genome of human.


MTX1_HUMAN Metaxin-1 (sprot)

A metaxin-1 that is encoded in the genome of human.


name: NAB1_HUMAN NGFI-A-binding protein 1 (sprot)

description: An NGFI-A-binding protein 1 that is encoded in the genome of human.


name: TRPC3_HUMAN Short transient receptor potential channel 3 (sprot)

description: A short transient receptor potential cation channel TRPC3 that is encoded in the genome of human.


name: calcium-activated cation channel activity

description: Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient.


name: NAR3_HUMAN Ecto-ADP-ribosyltransferase 3 (sprot)

description: An ecto-ADP-ribosyltransferase 3 that is encoded in the genome of human.


TBB3_HUMAN Tubulin beta-3 chain (sprot)

A tubulin beta-3 chain that is encoded in the genome of human.


ASAH1_HUMAN Acid ceramidase (sprot)

An acid ceramidase that is encoded in the genome of human.


name: regulation of programmed necrotic cell death

description: Any process that modulates the frequency, rate or extent of programmed necrotic cell death.


BFSP2_HUMAN Phakinin (sprot)

A phakinin that is encoded in the genome of human.


name: OLIG2_HUMAN Oligodendrocyte transcription factor 2 (sprot)

description: An oligodendrocyte transcription factor 2 that is encoded in the genome of human.


PNOC_HUMAN Prepronociceptin (sprot)

A nociceptin that is encoded in the genome of human.


AQP6_HUMAN Aquaporin-6 (sprot)

An aquaporin-6 that is encoded in the genome of human.


nitrate transmembrane transport

description: The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: PPR1A_HUMAN Protein phosphatase 1 regulatory subunit 1A (sprot)

description: A protein phosphatase 1 regulatory subunit 1A that is encoded in the genome of human.


name: PRP4K_HUMAN Serine/threonine-protein kinase PRP4 homolog (sprot)

description: A serine/threonine-protein kinase PRP4 that is encoded in the genome of human.


name: PIN1_HUMAN Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (sprot)

description: A peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 that is encoded in the genome of human.


cis-trans isomerase activity

description: Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers.


name: SERC3_HUMAN Serine incorporator 3 (sprot)

description: A serine incorporator 3 that is encoded in the genome of human.


name: ATR_HUMAN Serine/threonine-protein kinase ATR (sprot)

description: A serine/threonine-protein kinase ATR that is encoded in the genome of human.


ATR-ATRIP complex

description: A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A.


CROC4_HUMAN Protein CROC-4 (sprot)

A protein that is a translation product of the MIR9-1HG gene in human.


name: 4EBP1_HUMAN Eukaryotic translation initiation factor 4E-binding protein 1 (sprot)

description: A eukaryotic translation initiation factor 4E-binding protein 1 that is encoded in the genome of human.


name: 4EBP2_HUMAN Eukaryotic translation initiation factor 4E-binding protein 2 (sprot)

description: A eukaryotic translation initiation factor 4E-binding protein 2 that is encoded in the genome of human.


name: RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (sprot)

description: A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human.


positive regulation of miRNA processing

description: Any process that activates or increases the frequency, rate or extent of microRNA processing.


name: positive regulation of interleukin-6-mediated signaling pathway

description: Any process that increases the rate, frequency or extent of an interleukin-6-mediated signaling pathway.


name: regulation of ATP:ADP antiporter activity

description: Any process that modulates the activity of an ATP:ADP antiporter.


ripoptosome assembly

description: The aggregation, arrangement and bonding together of a set of components to form a ripoptosome, a protein complex whose formation can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more.


name: ripoptosome assembly involved in necroptotic process

description: The aggregation, arrangement and bonding together of ripoptosome components leading to a necroptotic process.


name: HDAC1_HUMAN Histone deacetylase 1 (sprot)

description: A histone deacetylase 1 that is encoded in the genome of human.


name: KCC2B_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit beta (sprot)

description: A calcium/calmodulin-dependent protein kinase type II subunit beta that is encoded in the genome of human.


name: calcium-dependent protein serine/threonine kinase activity

description: Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.


name: regulation of skeletal muscle adaptation

description: Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.


name: calcium- and calmodulin-dependent protein kinase complex

description: An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins.


name: KCC2G_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit gamma (sprot)

description: A calcium/calmodulin-dependent protein kinase type II subunit gamma that is encoded in the genome of human.


name: KCC2D_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit delta (sprot)

description: A calcium/calmodulin-dependent protein kinase type II subunit delta that is encoded in the genome of human.


regulation of cellular localization

description: Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.


name: negative regulation of sodium ion transmembrane transport

description: Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport.


DCTN2_HUMAN Dynactin subunit 2 (sprot)

A dynactin subunit 2 that is encoded in the genome of human.


name: NDF1_HUMAN Neurogenic differentiation factor 1 (sprot)

description: A neurogenic differentiation factor 1 that is encoded in the genome of human.


name: regulation of intestinal epithelial structure maintenance

description: Any process that modulates the rate, frequency, or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.


PKD2_HUMAN Polycystin-2 (sprot)

A polycystin-2 that is encoded in the genome of human.


HLH domain binding

description: Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.


detection of nodal flow

description: The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry.