inner cell mass cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.


pronephric nephron tubule development

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct.


ureteric bud elongation

description: The developmental growth in which the ureteric bud grows along its axis beginning with the growth of the primary ureteric bud and ending when the branches of the bud have elongated.


name: negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis

description: Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros.


name: regulation of branch elongation involved in ureteric bud branching

description: Any process that modulates the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis.


name: mesenchymal cell apoptotic process involved in metanephros development

description: Any mesenchymal cell apoptotic process that is involved in metanephros development.


name: negative regulation of mesenchymal cell apoptotic process involved in metanephros development

description: Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development.


name: SOX5_HUMAN Transcription factor SOX-5 (sprot)

description: A transcription factor SOX-5 that is encoded in the genome of human.


asymmetric neuroblast division

description: The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials.


name: positive regulation of mesenchymal stem cell differentiation

description: Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell differentiation.


name: SOX6_HUMAN Transcription factor SOX-6 (sprot)

description: A transcription factor SOX-6 that is encoded in the genome of human.


name: spinal cord oligodendrocyte cell differentiation

description: The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate.


name: SOX18_HUMAN Transcription factor SOX-18 (sprot)

description: A transcription factor SOX-18 that is encoded in the genome of human.


stem cell fate specification

description: The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.


endocardium formation

description: Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.


endocardial cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers.


name: SOX11_HUMAN Transcription factor SOX-11 (sprot)

description: A transcription factor SOX-11 that is encoded in the genome of human.


closure of optic fissure

description: The closure of the temporary ventral gap in the optic cup that contributes to its shaping.


name: positive regulation of lens epithelial cell proliferation

description: Any process that activates or increases the frequency, rate or extent of lens epithelial cell proliferation.


MYH11_HUMAN Myosin-11 (sprot)

A myosin-11 that is encoded in the genome of human.


GLRX1_HUMAN Glutaredoxin-1 (sprot)

A glutaredoxin-1 that is encoded in the genome of human.


name: glutathione disulfide oxidoreductase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor.


name: positive regulation of membrane potential

description: Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


name: ZNF93_HUMAN Zinc finger protein 93 (sprot)

description: A zinc finger protein 93 that is encoded in the genome of human.


CHKA_HUMAN Choline kinase alpha (sprot)

A choline kinase alpha that is encoded in the genome of human.


choline kinase activity

description: Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H+.


ethanolamine kinase activity

description: Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine.


name: PPM1A_HUMAN Protein phosphatase 1A (sprot)

description: A protein phosphatase 1A that is encoded in the genome of human.


name: ALS_HUMAN Insulin-like growth factor-binding protein complex acid labile subunit (sprot)

description: An insulin-like growth factor-binding protein complex acid labile chain that is encoded in the genome of human.


name: AHR_HUMAN Aryl hydrocarbon receptor (sprot)

description: An aryl hydrocarbon receptor that is encoded in the genome of human.


name: cytosolic aryl hydrocarbon receptor complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP.


name: K1C20_HUMAN Keratin, type I cytoskeletal 20 (sprot)

description: A keratin, type I cytoskeletal 20 that is encoded in the genome of human.


name: K22E_HUMAN Keratin, type II cytoskeletal 2 epidermal (sprot)

description: A keratin, type II cytoskeletal 2 epidermal that is encoded in the genome of human.


keratinocyte activation

description: A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines.


name: PDE6B_HUMAN Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (sprot)

description: A rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta that is encoded in the genome of human.


retinal cell apoptotic process

description: Any apoptotic process in a retinal cell.


name: HMGCL_HUMAN Hydroxymethylglutaryl-CoA lyase, mitochondrial (sprot)

description: A hydroxymethylglutaryl-CoA lyase, mitochondrial that is encoded in the genome of human.


description: Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.


ketone body biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.


name: VGFR3_HUMAN Vascular endothelial growth factor receptor 3 (sprot)

description: A vascular endothelial growth factor receptor 3 that is encoded in the genome of human.


name: VGFR2_HUMAN Vascular endothelial growth factor receptor 2 (sprot)

description: A vascular endothelial growth factor receptor 2 that is encoded in the genome of human.


endocardium development

description: The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.


name: blood vessel endothelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels.


cellular response to hydrogen sulfide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus.


name: PRS7_HUMAN 26S proteasome regulatory subunit 7 (sprot)

description: A 26S proteasome regulatory subunit 7 that is encoded in the genome of human.


name: MOT8_HUMAN Monocarboxylate transporter 8 (sprot)

description: A monocarboxylate transporter 8 that is encoded in the genome of human.


name: thyroid hormone transmembrane transporter activity

description: Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.


thyroid-stimulating hormone secretion

description: The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary.


name: CH3L1_HUMAN Chitinase-3-like protein 1 (sprot)

description: A chitinase-3-like protein 1 that is encoded in the genome of human.


chitinase activity

description: Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins.


chitin binding

description: Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.


name: GGT2_HUMAN Inactive glutathione hydrolase 2 (sprot)

description: A gamma-glutamyltranspeptidase 2 that is encoded in the genome of human.


name: GGT5_HUMAN Glutathione hydrolase 5 proenzyme (sprot)

description: A glutathione hydrolase 5 proenzyme that is encoded in the genome of human.


name: CXA5_HUMAN Gap junction alpha-5 protein (sprot)

description: A gap junction alpha-5 protein that is encoded in the genome of human.


name: gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling

description: A wide pore channel activity that enables a direct cytoplasmic connection from an SA node cell to an atrial cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


name: gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling

description: A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


name: gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling

description: A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


name: gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling

description: A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


name: gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling

description: A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


mitral valve development

description: The progression of the mitral valve over time, from its formation to the mature structure.


pulmonary valve formation

description: The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.


name: positive regulation of cell communication by chemical coupling

description: Any process that increases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels.


name: SA node cell to atrial cardiac muscle cell communication by electrical coupling

description: The process that mediates signaling interactions between an SA node cardiomyocyte and an atrial cardiomyocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels.


name: atrial cardiac muscle cell to AV node cell communication by electrical coupling

description: The process that mediates signaling interactions between an atrial cardiomyocyte and an AV node cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.


name: AV node cell to bundle of His cell communication by electrical coupling

description: The process that mediates signaling interactions between an AV node cardiomyocyte and a bundle of His cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.


name: bundle of His cell to Purkinje myocyte communication by electrical coupling

description: The process that mediates signaling interactions between a bundle of His cardiac muscle cell and a Purkinje myocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels.


name: Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling

description: The process that mediates signaling interactions between a Purkinje myocyte and a ventricular cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.


name: regulation of AV node cell action potential

description: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


name: regulation of bundle of His cell action potential

description: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell of the bundle of His. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


name: regulation of Purkinje myocyte action potential

description: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


name: regulation of atrial cardiac muscle cell action potential

description: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrial cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


vasomotion

description: The rhythmical contraction and relaxation of arterioles, observed as slow and fast waves, with frequencies of 1-2 and 10-20 cpm.


name: CXG1_HUMAN Gap junction gamma-1 protein (sprot)

description: A gap junction gamma-1 protein that is encoded in the genome of human.


name: TCF7_HUMAN Transcription factor 7 (sprot)

description: A transcription factor 7 that is encoded in the genome of human.


name: regulation of gamma-delta T cell differentiation

description: Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation.


name: ARL2_HUMAN ADP-ribosylation factor-like protein 2 (sprot)

description: An ADP-ribosylation factor-like protein 2 that is encoded in the genome of human.


name: ARL3_HUMAN ADP-ribosylation factor-like protein 3 (sprot)

description: An ADP-ribosylation factor-like protein 3 that is encoded in the genome of human.


photoreceptor cell development

description: Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.


name: TRI23_HUMAN E3 ubiquitin-protein ligase TRIM23 (sprot)

description: An E3 ubiquitin-protein ligase TRIM23 that is encoded in the genome of human.


name: MP2K2_HUMAN Dual specificity mitogen-activated protein kinase kinase 2 (sprot)

description: A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of human.


MAP-kinase scaffold activity

description: The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.


name: ZNF76_HUMAN Zinc finger protein 76 (sprot)

description: A zinc finger protein 76 that is encoded in the genome of human.


name: UDB10_HUMAN UDP-glucuronosyltransferase 2B10 (sprot)

description: A UDP-glucuronosyltransferase 2B10 that is encoded in the genome of human.


name: ATPG_HUMAN ATP synthase subunit gamma, mitochondrial (sprot)

description: An ATP synthase subunit gamma, mitochondrial that is encoded in the genome of human.


name: VATE1_HUMAN V-type proton ATPase subunit E 1 (sprot)

description: A V-type proton ATPase subunit E 1 that is encoded in the genome of human.


name: ACHA7_HUMAN Neuronal acetylcholine receptor subunit alpha-7 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of human.


sensory processing

description: Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect.


dendritic spine organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.


name: HEM6_HUMAN Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (sprot)

description: An oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial that is encoded in the genome of human.


coproporphyrinogen oxidase activity

description: Catalysis of the reaction: coproporphyrinogen III + 2 H+ + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX.


ARRC_HUMAN Arrestin-C (sprot)

An arrestin-C that is encoded in the genome of human.


name: RL4_HUMAN Large ribosomal subunit protein uL4 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL4 that is encoded in the genome of human.


name: 8ODP_HUMAN Oxidized purine nucleoside triphosphate hydrolase (sprot)

description: An oxidized purine nucleoside triphosphate hydrolase that is encoded in the genome of human.


name: 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity

description: Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription.


dATP diphosphatase activity

description: Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate.


name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

description: Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.


name: 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity

description: Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.


2-hydroxy-ATP hydrolase activity

description: Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + H+ + diphosphate.


2-hydroxy-dATP hydrolase activity

description: Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + H+ + diphosphate.


N6-methyl-(d)ATP hydrolase activity

description: Catalysis of the reaction N6-methyl-(d)ATP + H2O = N6-methyl-(d)AMP + diphosphate + H+.


O6-methyl-dGTP hydrolase activity

description: Catalysis of the reaction O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+.


purine nucleoside catabolic process

description: The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).


name: LONM_HUMAN Lon protease homolog, mitochondrial (sprot)

description: A Lon protease, mitochondrial that is encoded in the genome of human.


name: mitochondrial promoter sequence-specific DNA binding

description: Binding to a DNA region that controls the transcription of the mitochondrial DNA.


name: oxidation-dependent protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein.


PGM1_HUMAN Phosphoglucomutase-1 (sprot)

A phosphoglucomutase-1 that is encoded in the genome of human.


phosphoglucomutase activity

description: Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.


name: galactose catabolic process via UDP-galactose

description: The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose.


name: PP1G_HUMAN Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (sprot)

description: A serine/threonine-protein phosphatase PP1-gamma catalytic subunit that is encoded in the genome of human.


name: FLT3_HUMAN Receptor-type tyrosine-protein kinase FLT3 (sprot)

description: A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of human.


leukocyte homeostasis

description: The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.


pro-B cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed.


name: BMR1A_HUMAN Bone morphogenetic protein receptor type-1A (sprot)

description: A BMP receptor type-1A that is encoded in the genome of human.


name: transforming growth factor beta receptor activity, type I

description: Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals.


tricuspid valve morphogenesis

description: The process in which the structure of the tricuspid valve is generated and organized.


name: neural plate mediolateral regionalization

description: The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate.


name: paraxial mesoderm structural organization

description: The process that contributes to the act of creating the structural organization of the paraxial mesoderm. This process pertains to the physical shaping of a rudimentary structure.


lateral mesoderm development

description: The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure.


name: regulation of cardiac muscle cell proliferation

description: Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation.


heart formation

description: The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable.


atrioventricular node cell development

description: The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state.


name: positive regulation of cardiac ventricle development

description: Any process that activates or increases the frequency, rate or extent of cardiac ventricle development.


fibrous ring of heart morphogenesis

description: The developmental process by which a fibrous ring of heart is generated and organized.


name: ACV1B_HUMAN Activin receptor type-1B (sprot)

description: An activin receptor type-1B that is encoded in the genome of human.


activin receptor activity, type I

description: Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals.


activin receptor complex

description: A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed.


name: TGFR1_HUMAN TGF-beta receptor type-1 (sprot)

description: A TGF-beta receptor type-1 that is encoded in the genome of human.


proepicardium development

description: The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum.


name: transforming growth factor beta receptor activity

description: Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.


extracellular structure organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.


epicardium morphogenesis

description: The developmental process by which an epicardium is generated and organized.


name: transforming growth factor beta ligand-receptor complex

description: A protein complex that is formed by the association of a TGF-beta dimeric ligand with 2 molecules of each receptor molecule, TGF-beta type I receptor and TGF-beta type II receptor. The receptor molecules may form homo- or heterodimers but only once bound by the ligand.


name: GNL1_HUMAN Guanine nucleotide-binding protein-like 1 (sprot)

description: A guanine nucleotide-binding protein-like 1 that is encoded in the genome of human.


name: TNR3_HUMAN Tumor necrosis factor receptor superfamily member 3 (sprot)

description: A tumor necrosis factor receptor superfamily member 3 that is encoded in the genome of human.


name: hematopoietic or lymphoid organ development

description: The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation.


SPB5_HUMAN Serpin B5 (sprot)

A serpin B5 that is encoded in the genome of human.


name: RPB9_HUMAN DNA-directed RNA polymerase II subunit RPB9 (sprot)

description: A DNA-directed RNA polymerase II subunit RPB9 that is encoded in the genome of human.


name: PEDF_HUMAN Pigment epithelium-derived factor (sprot)

description: A pigment epithelium-derived factor that is encoded in the genome of human.


name: negative regulation of epithelial cell proliferation involved in prostate gland development

description: Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.


cellular response to cobalt ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus.


name: SRBP1_HUMAN Sterol regulatory element-binding protein 1 (sprot)

description: A sterol regulatory element-binding protein 1 that is encoded in the genome of human.


sterol response element binding

description: Binding to a sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism.


regulation of lipid storage

description: Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.


name: regulation of fatty acid metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.


name: ODO2_HUMAN Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (sprot)

description: A dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial that is encoded in the genome of human.


description: Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.


succinyl-CoA metabolic process

description: The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A.


name: L-lysine catabolic process to acetyl-CoA via saccharopine

description: The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine.


GMPR1_HUMAN GMP reductase 1 (sprot)

A GMP reductase 1 that is encoded in the genome of human.


GMP reductase activity

description: Catalysis of the reaction: IMP + NADP+ + NH4 = GMP + 2 H+ + NADPH.


purine nucleotide metabolic process

description: The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


GMP reductase complex

description: An oxidoreductase complex which is capable of GMP reductase activity. It catalyses the irreversible reaction: GMP + 2 H+ + NADPH => IMP + NADP+ + NH4.


name: GPX4_HUMAN Phospholipid hydroperoxide glutathione peroxidase GPX4 (sprot)

description: A phospholipid hydroperoxide glutathione peroxidase GPX4 that is encoded in the genome of human.


name: FHR2_HUMAN Complement factor H-related protein 2 (sprot)

description: A complement factor H-related protein 2 that is encoded in the genome of human.


name: ACVL1_HUMAN Serine/threonine-protein kinase receptor R3 (sprot)

description: A serine/threonine-protein kinase receptor R3 that is encoded in the genome of human.


name: negative regulation of endothelial cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation.


name: DHB3_HUMAN 17-beta-hydroxysteroid dehydrogenase type 3 (sprot)

description: A 17-beta-hydroxysteroid dehydrogenase type 3 that is encoded in the genome of human.


name: DHB2_HUMAN 17-beta-hydroxysteroid dehydrogenase type 2 (sprot)

description: A 17-beta-hydroxysteroid dehydrogenase type 2 that is encoded in the genome of human.


description: Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone.


name: SCNNA_HUMAN Amiloride-sensitive sodium channel subunit alpha (sprot)

description: An amiloride-sensitive sodium channel subunit alpha that is encoded in the genome of human.


ligand-gated sodium channel activity

description: Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.


sensory perception of salty taste

description: The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


sensory perception of sour taste

description: The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


sodium channel complex

description: An ion channel complex through which sodium ions pass.


name: SRP14_HUMAN Signal recognition particle 14 kDa protein (sprot)

description: A signal recognition particle 14 kDa protein that is encoded in the genome of human.


name: endoplasmic reticulum signal peptide binding

description: Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.


name: SRP-dependent cotranslational protein targeting to membrane

description: The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.


name: TGFR2_HUMAN TGF-beta receptor type-2 (sprot)

description: A TGF-beta receptor type-2 that is encoded in the genome of human.


name: transforming growth factor beta receptor activity, type II

description: Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor.


name: positive regulation of tolerance induction to self antigen

description: Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen.


name: positive regulation of B cell tolerance induction

description: Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction.


endocardial cushion fusion

description: The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping.


mammary gland morphogenesis

description: The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.


name: inferior endocardial cushion morphogenesis

description: The developmental process by which an inferior endocardial cushion is generated and organized.


name: NUP62_HUMAN Nuclear pore glycoprotein p62 (sprot)

description: A nuclear pore glycoprotein p62 that is encoded in the genome of human.


name: regulation of mitotic spindle organization

description: Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.


name: PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (sprot)

description: A peroxisome proliferator-activated receptor gamma that is encoded in the genome of human.


name: positive regulation of adiponectin secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell.


name: negative regulation of connective tissue replacement involved in inflammatory response wound healing

description: Any process that stops, prevents or reduces the frequency, rate or extent of wound healing connective tissue replacement, which may be replaced with fibrotic material, that occurs as part of an inflammatory response.


prostaglandin receptor activity

description: Combining with a prostaglandin (PG) to initiate a change in cell activity.


name: negative regulation of sequestering of triglyceride

description: Any process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.


name: regulation of cholesterol transporter activity

description: Any process that modulates the rate, frequency, or extent of cholesterol transporter activity.


name: negative regulation of extracellular matrix assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly.


name: HPCL1_HUMAN Hippocalcin-like protein 1 (sprot)

description: A hippocalcin-like protein 1 that is encoded in the genome of human.


FDFT_HUMAN Squalene synthase (sprot)

A squalene synthase that is encoded in the genome of human.


name: ZEB1_HUMAN Zinc finger E-box-binding homeobox 1 (sprot)

description: A zinc finger E-box-binding homeobox 1 that is encoded in the genome of human.


name: regulation of mesenchymal cell proliferation

description: Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


name: PIGA_HUMAN Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (sprot)

description: An N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein that is encoded in the genome of human.


UDP-glycosyltransferase activity

description: Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol.


name: V1AR_HUMAN Vasopressin V1a receptor (sprot)

description: A vasopressin V1a receptor that is encoded in the genome of human.


cellular response to water deprivation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water.


TAGL2_HUMAN Transgelin-2 (sprot)

A transgelin-2 that is encoded in the genome of human.


TALDO_HUMAN Transaldolase (sprot)

A transaldolase that is encoded in the genome of human.


transaldolase activity

description: Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.


SYUA_HUMAN Alpha-synuclein (sprot)

An alpha-synuclein that is encoded in the genome of human.


neutral lipid metabolic process

description: The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity.


regulation of phospholipase activity

description: Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.


regulation of glutamate secretion

description: Any process that modulates the frequency, rate or extent of the controlled release of glutamate.


name: negative regulation of monooxygenase activity

description: Any process that stops or reduces the activity of a monooxygenase.


name: positive regulation of SNARE complex assembly

description: Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


name: regulation of acyl-CoA biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA.


name: negative regulation of dopamine uptake involved in synaptic transmission

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell.


regulation of norepinephrine uptake

description: Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell.


name: negative regulation of norepinephrine uptake

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell.


name: negative regulation of mitochondrial electron transport, NADH to ubiquinone

description: Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone.


name: positive regulation of glutathione peroxidase activity

description: Any process that activates or increases the frequency, rate or extent of glutathione peroxidase activity.


name: positive regulation of hydrogen peroxide catabolic process

description: Any process that activates or increases the frequency, rate or extent of hydrogen peroxide catabolic process.


name: regulation of synaptic vesicle recycling

description: Any process that modulates the frequency, rate or extent of synaptic vesicle recycling.


name: ETFB_HUMAN Electron transfer flavoprotein subunit beta (sprot)

description: An electron transfer flavoprotein subunit beta that is encoded in the genome of human.


name: RBMX_HUMAN RNA-binding motif protein, X chromosome (sprot)

description: An RNA-binding motif protein, X chromosome that is encoded in the genome of human.


supraspliceosomal complex

description: Multicomponent complex of RNA and proteins that is composed of four active spliceosomes, termed native spliceosomes, connected to each other by the pre-mRNA. The supraspliceosome is the nuclear machine where the pre-mRNA processing takes place, like the 5'-end capping, 3'-end cleavage, splicing and editing.


name: BRCA1_HUMAN Breast cancer type 1 susceptibility protein (sprot)

description: A breast cancer type 1 susceptibility protein that is encoded in the genome of human.


random inactivation of X chromosome

description: Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex.


nuclear ubiquitin ligase complex

description: A ubiquitin ligase complex found in the nucleus.


BRCA1-BARD1 complex

description: A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage.


BRCA1-A complex

description: A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites.


BRCA1-B complex

description: A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites.


gamma-tubulin ring complex

description: A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe.


name: GNAL_HUMAN Guanine nucleotide-binding protein G(olf) subunit alpha (sprot)

description: A guanine nucleotide-binding protein G(olf) subunit alpha that is encoded in the genome of human.


COIL_HUMAN Coilin (sprot)

A coilin that is encoded in the genome of human.


name: VKGC_HUMAN Vitamin K-dependent gamma-carboxylase (sprot)

description: A vitamin K-dependent gamma-carboxylase that is encoded in the genome of human.


gamma-glutamyl carboxylase activity

description: Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide.


name: INGR2_HUMAN Interferon gamma receptor 2 (sprot)

description: An interferon-gamma receptor beta chain that is encoded in the genome of human.


HYALP_HUMAN Hyaluronidase PH-20 (sprot)

A hyaluronidase PH-20 that is encoded in the genome of human.


ITAE_HUMAN Integrin alpha-E (sprot)

An integrin alpha-E that is encoded in the genome of human.


name: LICH_HUMAN Lysosomal acid lipase/cholesteryl ester hydrolase (sprot)

description: A lysosomal acid lipase/cholesteryl ester hydrolase that is encoded in the genome of human.


liver morphogenesis

description: The process in which the anatomical structures of the liver are generated and organized.


cellular lipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of lipids, as carried out by individual cells.


lipid import into cell

description: The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.


name: multicellular organismal-level chemical homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.


response to rapamycin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus.


name: VATA_HUMAN V-type proton ATPase catalytic subunit A (sprot)

description: A V-type proton ATPase catalytic subunit A that is encoded in the genome of human.


name: GRP75_HUMAN Stress-70 protein, mitochondrial (sprot)

description: A stress-70 protein, mitochondrial that is encoded in the genome of human.


negative regulation of hemopoiesis

description: Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis.


name: IF4A3_HUMAN Eukaryotic initiation factor 4A-III (sprot)

description: A eukaryotic initiation factor 4A-III that is encoded in the genome of human.


name: selenocysteine insertion sequence binding

description: Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation.


cellular response to selenite ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus.


name: negative regulation of selenocysteine incorporation

description: Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine incorporation.


name: SMBP2_HUMAN DNA-binding protein SMUBP-2 (sprot)

description: A DNA-binding protein SMUBP-2 that is encoded in the genome of human.


5'-3' RNA helicase activity

description: Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis.


double-stranded DNA helicase activity

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix.


name: CDN1A_HUMAN Cyclin-dependent kinase inhibitor 1 (sprot)

description: A cyclin-dependent kinase inhibitor 1 that is encoded in the genome of human.


name: cyclin-dependent protein kinase activating kinase activity

description: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK).


name: cellular response to cell-matrix adhesion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion.


stress-induced premature senescence

description: A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.


name: negative regulation of cyclin-dependent protein kinase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity.


name: negative regulation of cardiac muscle tissue regeneration

description: Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle tissue regeneration.


name: RS19_HUMAN Small ribosomal subunit protein eS19 (sprot)

description: A small ribosomal subunit protein eS19 that is encoded in the genome of human.


nucleolus organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus.


name: RL3_HUMAN Large ribosomal subunit protein uL3 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL3 that is encoded in the genome of human.


name: COFA1_HUMAN Collagen alpha-1(XV) chain (sprot)

description: A collagen alpha-1(XV) chain that is encoded in the genome of human.


collagen type XV trimer

description: A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes where it bridges between fibrils.


name: COIA1_HUMAN Collagen alpha-1(XVIII) chain (sprot)

description: A collagen alpha-1(XVIII) chain that is encoded in the genome of human.


name: GRIK1_HUMAN Glutamate receptor ionotropic, kainate 1 (sprot)

description: A glutamate receptor ionotropic, kainate 1 that is encoded in the genome of human.


name: kainate selective glutamate receptor activity

description: An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist.


MPV17_HUMAN Protein Mpv17 (sprot)

A protein Mpv17 that is encoded in the genome of human.


name: regulation of mitochondrial DNA metabolic process

description: Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process.


name: OST48_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (sprot)

description: A dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit that is encoded in the genome of human.


name: AN32A_HUMAN Acidic leucine-rich nuclear phosphoprotein 32 family member A (sprot)

description: An acidic leucine-rich nuclear phosphoprotein 32 family member A that is encoded in the genome of human.


FEN1_HUMAN Flap endonuclease 1 (sprot)

A flap endonuclease 1 that is encoded in the genome of human.


5'-flap endonuclease activity

description: Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.


flap endonuclease activity

description: Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis.


name: telomere maintenance via semi-conservative replication

description: The process in which telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors as part of cell cycle DNA replication.


DNA replication, removal of RNA primer

description: Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease.


name: PA2G5_HUMAN Phospholipase A2 group V (sprot)

description: A phospholipase A2 group V that is encoded in the genome of human.


name: positive regulation of immune complex clearance by monocytes and macrophages

description: Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages.


name: positive regulation of phagosome maturation

description: Any process that activates or increases the frequency, rate or extent of phagosome maturation.


name: CUX1_HUMAN Homeobox protein cut-like 1 (sprot)

description: A CUX1 gene translation product (human), isoforms h1, h2, h3, h5, h6, h7, and h11.


name: MMP12_HUMAN Macrophage metalloelastase (sprot)

description: A macrophage metalloelastase that is encoded in the genome of human.


name: negative regulation of endothelial cell-matrix adhesion via fibronectin

description: Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin.


name: GDNF_HUMAN Glial cell line-derived neurotrophic factor (sprot)

description: A glial cell line-derived neurotrophic factor that is encoded in the genome of human.


name: chemoattractant activity involved in axon guidance

description: Any chemoattractant activity that is involved in axon guidance.


name: postganglionic parasympathetic fiber development

description: The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.


chemoattraction of axon

description: The process in which a neuron growth cone is directed to a specific target site in response to an attractive chemical signal.


name: CAPG_HUMAN Macrophage-capping protein (sprot)

description: A macrophage-capping protein that is encoded in the genome of human.


name: CAP2_HUMAN Adenylyl cyclase-associated protein 2 (sprot)

description: An adenylyl cyclase-associated protein 2 that is encoded in the genome of human.


name: presynaptic actin cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton.


name: TYRP2_HUMAN L-dopachrome tautomerase (sprot)

description: An L-dopachrome tautomerase that is encoded in the genome of human.


name: ADCY8_HUMAN Adenylate cyclase type 8 (sprot)

description: An adenylate cyclase type 8 that is encoded in the genome of human.


name: calcium- and calmodulin-responsive adenylate cyclase activity

description: Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin.


glucose mediated signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process in which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes.


activation of protein kinase A activity

description: Any process that initiates the activity of the inactive enzyme protein kinase A.


name: IL6RB_HUMAN Interleukin-6 receptor subunit beta (sprot)

description: An interleukin-6 receptor subunit beta that is encoded in the genome of human.


name: leukemia inhibitory factor receptor activity

description: Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


oncostatin-M receptor activity

description: Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


interleukin-11 receptor activity

description: Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


interleukin-11 binding

description: Binding to interleukin-11.


interleukin-27 receptor activity

description: Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: positive regulation of adaptive immune response

description: Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.


oncostatin-M receptor complex

description: A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta.


name: GPV_HUMAN Platelet glycoprotein V (sprot)

description: A platelet glycoprotein V that is encoded in the genome of human.


name: CEAM3_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 3 (sprot)

description: A carcinoembryonic antigen-related cell adhesion molecule 3 that is encoded in the genome of human.


name: CEAM6_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 6 (sprot)

description: A carcinoembryonic antigen-related cell adhesion molecule 6 that is encoded in the genome of human.


name: TACT_HUMAN T-cell surface protein tactile (sprot)

description: A T-cell surface protein tactile that is encoded in the genome of human.


NCYM_HUMAN N-cym protein (sprot)

An N-cym protein that is encoded in the genome of human.


TXLNA_HUMAN Alpha-taxilin (sprot)

An alpha-taxilin that is encoded in the genome of human.


TPO_HUMAN Thrombopoietin (sprot)

A thrombopoietin that is encoded in the genome of human.


description: The series of molecular signals initiated by thrombopoietin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: TCPZ_HUMAN T-complex protein 1 subunit zeta (sprot)

description: A T-complex protein 1 subunit zeta that is encoded in the genome of human.


WD40-repeat domain binding

description: Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain.


name: TPOR_HUMAN Thrombopoietin receptor (sprot)

description: A thrombopoietin receptor that is encoded in the genome of human.


thrombopoietin receptor activity

description: Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: positive regulation of platelet formation

description: Any process that activates or increases the frequency, rate or extent of platelet formation.


basophil homeostasis

description: The process of regulating the proliferation and elimination of basophils such that the total number of basophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.


name: CD79B_HUMAN B-cell antigen receptor complex-associated protein beta chain (sprot)

description: A B-cell antigen receptor complex-associated protein beta chain that is encoded in the genome of human.


name: NNMT_HUMAN Nicotinamide N-methyltransferase (sprot)

description: A nicotinamide N-methyltransferase that is encoded in the genome of human.


description: Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine.


pyridine N-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine.


nicotinamide metabolic process

description: The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms.


name: NAD biosynthesis via nicotinamide riboside salvage pathway

description: The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside.


name: IFI27_HUMAN Interferon alpha-inducible protein 27, mitochondrial (sprot)

description: An interferon alpha-inducible protein 27 that is encoded in the genome of human.


name: modulation by host of viral genome replication

description: A process in which a host organism modulates the frequency, rate or extent of viral genome replication.


name: PSB10_HUMAN Proteasome subunit beta type-10 (sprot)

description: A proteasome subunit beta type-10 that is encoded in the genome of human.


name: CTRL_HUMAN Chymotrypsin-like protease CTRL-1 (sprot)

description: A chymotrypsin-like protease CTRL-1 that is encoded in the genome of human.


name: VHL_HUMAN von Hippel-Lindau disease tumor suppressor (sprot)

description: A von Hippel-Lindau disease tumor suppressor that is encoded in the genome of human.


name: ADH7_HUMAN All-trans-retinol dehydrogenase [NAD(+)] ADH7 (sprot)

description: An all-trans-retinol dehydrogenase [NAD(+)] ADH7 that is encoded in the genome of human.


aldehyde oxidase activity

description: Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.


ethanol binding

description: Binding to ethanol, CH(3)-CH(2)-OH.


description: Catalysis of the reaction: 10-hydroxydecanoate + NAD+ = 10-oxodecanoate + H+ + NADH.


name: PBX1_HUMAN Pre-B-cell leukemia transcription factor 1 (sprot)

description: A pre-B-cell leukemia transcription factor 1 that is encoded in the genome of human.


name: PBX2_HUMAN Pre-B-cell leukemia transcription factor 2 (sprot)

description: A pre-B-cell leukemia transcription factor 2 that is encoded in the genome of human.


name: PBX3_HUMAN Pre-B-cell leukemia transcription factor 3 (sprot)

description: A pre-B-cell leukemia transcription factor 3 that is encoded in the genome of human.


anterior compartment pattern formation

description: The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo.


posterior compartment specification

description: The process involved in the specification of cell identity in the posterior compartments of the segmented embryo.


name: RL13A_HUMAN Large ribosomal subunit protein uL13 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL13 that is encoded in the genome of human.


name: negative regulation of formation of translation preinitiation complex

description: Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation preinitiation complex.


large ribosomal subunit

description: The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).


name: ARL1_HUMAN ADP-ribosylation factor-like protein 1 (sprot)

description: An ADP-ribosylation factor-like protein 1 that is encoded in the genome of human.


toxin metabolic process

description: The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.


name: ARL4A_HUMAN ADP-ribosylation factor-like protein 4A (sprot)

description: An ADP-ribosylation factor-like protein 4A that is encoded in the genome of human.


name: MLH1_HUMAN DNA mismatch repair protein Mlh1 (sprot)

description: A DNA mismatch repair protein Mlh1 that is encoded in the genome of human.


MutSalpha complex binding

description: Binding to a MutSalpha mismatch repair complex.


name: meiotic metaphase I homologous chromosome alignment

description: A cell cycle process whereby homlogous chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator) by the spindle machinery and centromere/kinetochore arrangement during meiosis I chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division.


meiotic telomere clustering

description: The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis.


name: negative regulation of mitotic recombination

description: Any process that inhibits or decreases the rate of DNA recombination during mitosis.


meiotic spindle midzone assembly

description: The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis.


chiasma

description: A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over.


late recombination nodule

description: An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I.


name: STAT3_HUMAN Signal transducer and activator of transcription 3 (sprot)

description: A signal transducer and activator of transcription 3 that is encoded in the genome of human.


RNA sequestering activity

description: Binding to a specific RNA molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.


eye photoreceptor cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.


name: UBP8_HUMAN Ubiquitin carboxyl-terminal hydrolase 8 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 8 that is encoded in the genome of human.


name: negative regulation of lysosomal protein catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process.


name: PEX19_HUMAN Peroxisomal biogenesis factor 19 (sprot)

description: A peroxisomal biogenesis factor 19 that is encoded in the genome of human.


name: peroxisome membrane class-1 targeting sequence binding

description: Binding to a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner.


protein import into peroxisome membrane

description: The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import.


name: establishment of protein localization to peroxisome

description: The directed movement of a protein to a specific location in a peroxisome.


negative regulation of lipid binding

description: Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding.


name: S26A3_HUMAN Chloride anion exchanger (sprot)

description: A chloride anion exchanger that is encoded in the genome of human.


name: MDHC_HUMAN Malate dehydrogenase, cytoplasmic (sprot)

description: A malate dehydrogenase, cytoplasmic that is encoded in the genome of human.


diiodophenylpyruvate reductase activity

description: Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H+ + NADH.


description: Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH.


name: MDHM_HUMAN Malate dehydrogenase, mitochondrial (sprot)

description: A malate dehydrogenase, mitochondrial that is encoded in the genome of human.


malate dehydrogenase (NADP+) activity

description: Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+.


IL15_HUMAN Interleukin-15 (sprot)

An interleukin-15 that is encoded in the genome of human.


natural killer cell proliferation

description: The expansion of a natural killer cell population by cell division.


NK T cell proliferation

description: The expansion of a NK T cell population by cell division.


extrathymic T cell selection

description: The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus.


name: positive regulation of protein O-linked glycosylation

description: Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation.


name: RFC5_HUMAN Replication factor C subunit 5 (sprot)

description: A replication factor C subunit 5 that is encoded in the genome of human.


name: RFC3_HUMAN Replication factor C subunit 3 (sprot)

description: A replication factor C subunit 3 that is encoded in the genome of human.


name: ECHA_HUMAN Trifunctional enzyme subunit alpha, mitochondrial (sprot)

description: A trifunctional enzyme subunit alpha, mitochondrial that is encoded in the genome of human.


description: Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+.


name: PMEL_HUMAN Melanocyte protein PMEL (sprot)

description: A melanocyte protein Pmel 17 that is encoded in the genome of human.


CCNF_HUMAN Cyclin-F (sprot)

A cyclin-F that is encoded in the genome of human.


anaphase-promoting complex binding

description: Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis.


name: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


name: IF2G_HUMAN Eukaryotic translation initiation factor 2 subunit 3 (sprot)

description: A eukaryotic translation initiation factor 2 subunit 3, X-linked that is encoded in the genome of human.


name: methionyl-initiator methionine tRNA binding

description: Binding to methionine-initiator methionine tRNA.


name: ID1_HUMAN DNA-binding protein inhibitor ID-1 (sprot)

description: A DNA-binding protein inhibitor ID-1 that is encoded in the genome of human.


name: negative regulation of transcription by transcription factor localization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor.


name: OPRD_HUMAN Delta-type opioid receptor (sprot)

description: A delta-type opioid receptor that is encoded in the genome of human.


name: G protein-coupled opioid receptor activity

description: Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein.


name: G protein-coupled enkephalin receptor activity

description: Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body.


spine apparatus

description: A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum.


name: OPRK_HUMAN Kappa-type opioid receptor (sprot)

description: A kappa-type opioid receptor that is encoded in the genome of human.


dynorphin receptor activity

description: Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin.


name: adenylate cyclase-inhibiting opioid receptor signaling pathway

description: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor, and ending with the regulation of a downstream cellular process.


name: sensory perception of temperature stimulus

description: The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


positive regulation of eating behavior

description: Any process that activates or increases the frequency, rate or extent of eating behavior.


OPRX_HUMAN Nociceptin receptor (sprot)

A nociceptin receptor that is encoded in the genome of human.


nociceptin receptor activity

description: Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein.


regulation of locomotor rhythm

description: Any process that modulates the frequency, rate or extent of locomotor rhythm.


LEP_HUMAN Leptin (sprot)

A leptin that is encoded in the genome of human.


negative regulation of appetite

description: Any process that reduces appetite.


name: regulation of natural killer cell proliferation

description: Any process that modulates the frequency, rate or extent of natural killer cell proliferation.


name: positive regulation of luteinizing hormone secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone.


name: negative regulation of appetite by leptin-mediated signaling pathway

description: The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food.


elastin metabolic process

description: The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue.


name: regulation of lipoprotein lipid oxidation

description: Any process that modulates the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group.


name: negative regulation of glucagon secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.


cellular response to L-ascorbic acid

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus.


name: regulation of brown fat cell differentiation

description: Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.


bone growth

description: The increase in size or mass of a bone that contributes to the shaping of that bone.


name: positive regulation of fat cell apoptotic process

description: Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process.


name: negative regulation of glutamine transport

description: Any process that stops, prevents or reduces the frequency, rate or extent of glutamine transport.


name: ETV5_HUMAN ETS translocation variant 5 (sprot)

description: An ETS translocation variant 5 that is encoded in the genome of human.


name: male germ-line stem cell asymmetric division

description: The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes.


name: ETV3_HUMAN ETS translocation variant 3 (sprot)

description: An ETS translocation variant 3 that is encoded in the genome of human.


DEAD/H-box RNA helicase binding

description: Binding to a DEAD/H-box RNA helicase.


name: CASR_HUMAN Extracellular calcium-sensing receptor (sprot)

description: An extracellular calcium-sensing receptor that is encoded in the genome of human.


AQP2_HUMAN Aquaporin-2 (sprot)

An aquaporin-2 that is encoded in the genome of human.


lumenal side of membrane

description: Any side (leaflet) of a membrane that faces the lumen of an organelle.


name: BCL6_HUMAN B-cell lymphoma 6 protein (sprot)

description: A B-cell lymphoma 6 protein that is encoded in the genome of human.


name: intronic transcription regulatory region sequence-specific DNA binding

description: Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within.


name: negative regulation of mast cell cytokine production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production.


name: regulation of memory T cell differentiation

description: Any process that modulates the frequency, rate, or extent of memory T cell differentiation.


isotype switching to IgE isotypes

description: The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus.


name: negative regulation of isotype switching to IgE isotypes

description: Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes.


name: negative regulation of mitotic cell cycle DNA replication

description: Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle DNA replication.


CETN2_HUMAN Centrin-2 (sprot)

A centrin-2 that is encoded in the genome of human.


XPC complex

description: A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2.


name: ETV6_HUMAN Transcription factor ETV6 (sprot)

description: A transcription factor ETV6 that is encoded in the genome of human.


name: EIF2D_HUMAN Eukaryotic translation initiation factor 2D (sprot)

description: A ligatin that is encoded in the genome of human.


name: OX2G_HUMAN OX-2 membrane glycoprotein (sprot)

description: An OX-2 membrane glycoprotein that is encoded in the genome of human.


name: protein binding involved in heterotypic cell-cell adhesion

description: Binding to a protein or protein complex contributing to the adhesion of two different types of cells.


glycosylated region protein binding

description: Binding to a glycosylated region of a protein.


name: negative regulation of leukocyte activation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.


name: positive regulation of arginase activity

description: Any process that activates or increases the frequency, rate or extent of arginase activity.


name: positive regulation of protein-glutamine gamma-glutamyltransferase activity

description: Any process that activates or increases the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity.


name: negative regulation of matrix metallopeptidase secretion

description: Any process that stops, prevents or reduces the frequency, rate or extent of matrix metallopeptidase secretion.


name: MNDA_HUMAN Myeloid cell nuclear differentiation antigen (sprot)

description: A myeloid cell nuclear differentiation antigen that is encoded in the genome of human.


PERI_HUMAN Peripherin (sprot)

A peripherin that is encoded in the genome of human.


name: RGS2_HUMAN Regulator of G-protein signaling 2 (sprot)

description: A regulator of G-protein signaling 2 that is encoded in the genome of human.


name: negative regulation of phospholipase activity

description: Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.


name: regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands.


name: negative regulation of glycine import across plasma membrane

description: Any process that stops, prevents or reduces the frequency, rate or extent of glycine import into a cell.


WNT5A_HUMAN Protein Wnt-5a (sprot)

A protein Wnt-5a that is encoded in the genome of human.


name: receptor tyrosine kinase-like orphan receptor binding

description: Binding to a receptor tyrosine kinase-like orphan receptor (Ror).


name: optic cup formation involved in camera-type eye development

description: The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle.


olfactory bulb interneuron development

description: The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell.


name: chemoattraction of serotonergic neuron axon

description: The process in which a serotonergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal.


name: negative regulation of melanin biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin.


genitalia development

description: The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure.


name: convergent extension involved in organogenesis

description: The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ.


cervix development

description: The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure.


name: planar cell polarity pathway involved in outflow tract morphogenesis

description: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the outflow tract.


name: planar cell polarity pathway involved in ventricular septum morphogenesis

description: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the ventricular septum.


name: planar cell polarity pathway involved in cardiac right atrium morphogenesis

description: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac right atrium.


name: planar cell polarity pathway involved in cardiac muscle tissue morphogenesis

description: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac muscle tissue.


name: planar cell polarity pathway involved in pericardium morphogenesis

description: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the pericardium.


name: planar cell polarity pathway involved in neural tube closure

description: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure.


melanocyte proliferation

description: The multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.


name: negative regulation of cell proliferation in midbrain

description: Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain.


name: positive regulation of non-canonical Wnt signaling pathway

description: Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway.


name: PTGDS_HUMAN Prostaglandin-H2 D-isomerase (sprot)

description: A prostaglandin-H2 D-isomerase that is encoded in the genome of human.


name: BUD31_HUMAN Protein BUD31 homolog (sprot)

description: A protein BUD31 that is encoded in the genome of human.


name: SOX3_HUMAN Transcription factor SOX-3 (sprot)

description: A transcription factor SOX-3 that is encoded in the genome of human.


sensory organ development

description: The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.


name: UBA7_HUMAN Ubiquitin-like modifier-activating enzyme 7 (sprot)

description: A ubiquitin-like modifier-activating enzyme 7 that is encoded in the genome of human.


ISG15 activating enzyme activity

description: Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond.


name: modification-dependent protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.


name: NAA10_HUMAN N-alpha-acetyltransferase 10 (sprot)

description: An N-alpha-acetyltransferase 10 that is encoded in the genome of human.


description: Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein.


acetyltransferase activity

description: Catalysis of the transfer of an acetyl group to an acceptor molecule.


name: N-terminal protein amino acid acetylation

description: The acetylation of the N-terminal amino acid of proteins.


name: negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric

description: Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region.


NatA complex

description: A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins.


name: KDM5C_HUMAN Lysine-specific demethylase 5C (sprot)

description: A lysine-specific demethylase 5C that is encoded in the genome of human.


P2RY2_HUMAN P2Y purinoceptor 2 (sprot)

A P2Y purinoceptor 2 that is encoded in the genome of human.


name: G protein-coupled purinergic nucleotide receptor activity

description: Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


name: HNF4A_HUMAN Hepatocyte nuclear factor 4-alpha (sprot)

description: A hepatocyte nuclear factor 4-alpha that is encoded in the genome of human.


ornithine metabolic process

description: The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.


name: IPP2_HUMAN Protein phosphatase inhibitor 2 (sprot)

description: A protein phosphatase inhibitor 2 that is encoded in the genome of human.


name: protein serine/threonine phosphatase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.


name: ABEC1_HUMAN C->U-editing enzyme APOBEC-1 (sprot)

description: A C->U-editing enzyme APOBEC-1 that is encoded in the genome of human.


mRNA modification

description: The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.


mRNA editing complex

description: A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes.


name: CSK_HUMAN Tyrosine-protein kinase CSK (sprot)

description: A tyrosine-protein kinase CSK that is encoded in the genome of human.


name: PLPL4_HUMAN Patatin-like phospholipase domain-containing protein 4 (sprot)

description: A patatin-like phospholipase domain-containing protein 4 that is encoded in the genome of human.


acylglycerol O-acyltransferase activity

description: Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule.


retinyl-palmitate esterase activity

description: Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+.


mono-olein transacylation activity

description: Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol.


diolein transacylation activity

description: Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein.


GARS_HUMAN Glycine--tRNA ligase (sprot)

A glycine--tRNA ligase that is encoded in the genome of human.


glycine-tRNA ligase activity

description: Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).


name: diadenosine tetraphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached.


name: SYIC_HUMAN Isoleucine--tRNA ligase, cytoplasmic (sprot)

description: An isoleucine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


isoleucyl-tRNA aminoacylation

description: The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


isoleucine-tRNA ligase activity

description: Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+.


name: NBL1_HUMAN Neuroblastoma suppressor of tumorigenicity 1 (sprot)

description: A neuroblastoma suppressor of tumorigenicity 1 that is encoded in the genome of human.


name: sequestering of BMP from receptor via BMP binding

description: Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor.


name: TNFL9_HUMAN Tumor necrosis factor ligand superfamily member 9 (sprot)

description: A tumor necrosis factor ligand superfamily member 9 that is encoded in the genome of human.


name: M3K8_HUMAN Mitogen-activated protein kinase kinase kinase 8 (sprot)

description: A mitogen-activated protein kinase kinase kinase 8 that is encoded in the genome of human.


name: FOLR3_HUMAN Folate receptor gamma (sprot)

description: A folate receptor gamma that is encoded in the genome of human.


name: S19A1_HUMAN Reduced folate transporter (sprot)

description: A reduced folate transporter that is encoded in the genome of human.


name: folate:monoatomic anion antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF.


name: methotrexate transmembrane transporter activity

description: Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.


2',3'-cyclic GMP-AMP binding

description: Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages.


name: cyclic-GMP-AMP transmembrane transporter activity

description: Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other.


methotrexate transport

description: The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.


name: cyclic-GMP-AMP transmembrane import across plasma membrane

description: The directed movement of cyclic-GMP-AMP from outside of a cell, across the plasma membrane and into the cytosol.


name: positive regulation of cGAS/STING signaling pathway

description: Any process that activates or increases the frequency, rate or extent of of cGAS/STING signaling pathway.


folate import across plasma membrane

description: The directed movement of folic acid from outside of a cell, across the plasma membrane and into the cytosol.


name: EIF1_HUMAN Eukaryotic translation initiation factor 1 (sprot)

description: A eukaryotic translation initiation factor 1 that is encoded in the genome of human.


name: positive regulation of mRNA cis splicing, via spliceosome

description: Any process that activates or increases the frequency, rate or extent of mRNA cis splicing, via spliceosome.