name: ARPC4_HUMAN Actin-related protein 2/3 complex subunit 4 (sprot)

description: An actin-related protein 2/3 complex subunit 4 that is encoded in the genome of human.


name: ELOF1_HUMAN Transcription elongation factor 1 homolog (sprot)

description: A transcription elongation factor 1 that is encoded in the genome of human.


name: APC15_HUMAN Anaphase-promoting complex subunit 15 (sprot)

description: An anaphase-promoting complex subunit 15 that is encoded in the genome of human.


name: HILS1_HUMAN Putative histone H1.9 (sprot)

description: A putative histone H1.9 that is encoded in the genome of human.


name: KR10A_HUMAN Keratin-associated protein 10-10 (sprot)

description: A keratin-associated protein 10-10 that is encoded in the genome of human.


DEFB1_HUMAN Beta-defensin 1 (sprot)

A beta-defensin 1 that is encoded in the genome of human.


CD81_HUMAN CD81 antigen (sprot)

A CD81 molecule that is encoded in the genome of human.


macrophage fusion

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The binding and fusion of a macrophage to one or more other cells to form a multinucleated cell.


name: CD4-positive, alpha-beta T cell costimulation

description: The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation.


name: positive regulation of protein exit from endoplasmic reticulum

description: Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum.


name: positive regulation of receptor clustering

description: Any process that activates or increases the frequency, rate or extent of receptor clustering.


name: positive regulation of protein catabolic process in the vacuole

description: Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole.


name: positive regulation of adaptive immune memory response

description: Any process that activates or increases the frequency, rate or extent of adaptive immune memory response.


name: SC61G_HUMAN Protein transport protein Sec61 subunit gamma (sprot)

description: A protein transport protein Sec61 subunit gamma that is encoded in the genome of human.


name: RNAS9_HUMAN Inactive ribonuclease-like protein 9 (sprot)

description: A ribonuclease-like protein 9 that is encoded in the genome of human.


name: TPIS_HUMAN Triosephosphate isomerase (sprot)

description: A triosephosphate isomerase that is encoded in the genome of human.


triose-phosphate isomerase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate.


methylglyoxal synthase activity

description: Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate.


methylglyoxal biosynthetic process

description: The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.


name: MYPR_HUMAN Myelin proteolipid protein (sprot)

description: A myelin proteolipid protein that is encoded in the genome of human.


name: AMPA selective glutamate receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: positive regulation of calcium ion transmembrane transport

description: Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport.


name: EIF3E_HUMAN Eukaryotic translation initiation factor 3 subunit E (sprot)

description: A eukaryotic translation initiation factor 3 subunit E that is encoded in the genome of human.


name: eukaryotic translation initiation factor 3 complex, eIF3e

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e.


NANO2_HUMAN Nanos homolog 2 (sprot)

A nanos homolog 2 that is encoded in the genome of human.


NANO3_HUMAN Nanos homolog 3 (sprot)

A nanos homolog 3 that is encoded in the genome of human.


name: KR123_HUMAN Keratin-associated protein 12-3 (sprot)

description: A keratin-associated protein 12-3 that is encoded in the genome of human.


name: KR124_HUMAN Keratin-associated protein 12-4 (sprot)

description: A keratin-associated protein 12-4 that is encoded in the genome of human.


name: KR101_HUMAN Keratin-associated protein 10-1 (sprot)

description: A keratin-associated protein 10-1 that is encoded in the genome of human.


name: KR102_HUMAN Keratin-associated protein 10-2 (sprot)

description: A keratin-associated protein 10-2 that is encoded in the genome of human.


name: KR103_HUMAN Keratin-associated protein 10-3 (sprot)

description: A keratin-associated protein 10-3 that is encoded in the genome of human.


name: KR105_HUMAN Keratin-associated protein 10-5 (sprot)

description: A keratin-associated protein 10-5 that is encoded in the genome of human.


name: KR106_HUMAN Keratin-associated protein 10-6 (sprot)

description: A keratin-associated protein 10-6 that is encoded in the genome of human.


name: KR104_HUMAN Keratin-associated protein 10-4 (sprot)

description: A keratin-associated protein 10-4 that is encoded in the genome of human.


name: KR107_HUMAN Keratin-associated protein 10-7 (sprot)

description: A keratin-associated protein 10-7 that is encoded in the genome of human.


name: KR108_HUMAN Keratin-associated protein 10-8 (sprot)

description: A keratin-associated protein 10-8 that is encoded in the genome of human.


name: KR109_HUMAN Keratin-associated protein 10-9 (sprot)

description: A keratin-associated protein 10-9 that is encoded in the genome of human.


name: KR10B_HUMAN Keratin-associated protein 10-11 (sprot)

description: A keratin-associated protein 10-11 that is encoded in the genome of human.


name: KR10C_HUMAN Keratin-associated protein 10-12 (sprot)

description: A keratin-associated protein 10-12 that is encoded in the genome of human.


name: SC61B_HUMAN Protein transport protein Sec61 subunit beta (sprot)

description: A protein transport protein Sec61 subunit beta that is encoded in the genome of human.


endoplasmic reticulum Sec complex

description: An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex.


name: PTEN_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (sprot)

description: A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN that is encoded in the genome of human.


description: Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate.


description: Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate.


description: Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.


name: phosphatidylinositol phosphate phosphatase activity

description: Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate.


name: spindle assembly involved in female meiosis

description: The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster.


rhythmic synaptic transmission

description: Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit.


postsynaptic density assembly

description: The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.


name: negative regulation of synaptic vesicle clustering

description: Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle clustering.


name: EFC1_HUMAN Endogenous retrovirus group FC1 Env polyprotein (sprot)

description: A protein that is a translation product of the ERVFC1 gene in human.


SYCY2_HUMAN Syncytin-2 (sprot)

A syncytin-2 that is encoded in the genome of human.


name: ERB1_HUMAN Endogenous retrovirus group PABLB member 1 Env polyprotein (sprot)

description: A protein that is a translation product of the ERVPABLB-1 gene in human.


name: PP4C_HUMAN Serine/threonine-protein phosphatase 4 catalytic subunit (sprot)

description: A serine/threonine-protein phosphatase 4 catalytic subunit that is encoded in the genome of human.


protein phosphatase 4 complex

description: A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits.


name: GBRL2_HUMAN Gamma-aminobutyric acid receptor-associated protein-like 2 (sprot)

description: A gamma-aminobutyric acid receptor-associated protein-like 2 that is encoded in the genome of human.


IL2_HUMAN Interleukin-2 (sprot)

An interleukin-2 that is encoded in the genome of human.


kappa-type opioid receptor binding

description: Binding to a kappa-type opioid receptor.


response to tacrolimus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus.


name: ROMO1_HUMAN Reactive oxygen species modulator 1 (sprot)

description: A reactive oxygen species modulator 1 that is encoded in the genome of human.


name: monoatomic cation transmembrane transporter activity

description: Enables the transfer of cation from one side of a membrane to the other.


name: UB2G2_HUMAN Ubiquitin-conjugating enzyme E2 G2 (sprot)

description: A ubiquitin-conjugating enzyme E2 G2 that is encoded in the genome of human.


name: negative regulation of retrograde protein transport, ER to cytosol

description: Any process that stops, prevents or reduces the frequency, rate or extent of retrograde protein transport, ER to cytosol.


CTXN1_HUMAN Cortexin-1 (sprot)

A cortexin-1 that is encoded in the genome of human.


name: EFC2_HUMAN Endogenous retrovirus group FC1 member 1 Env polyprotein (sprot)

description: A protein that is a translation product of the ERVFC1-1 gene in human.


name: MYL6_HUMAN Myosin light polypeptide 6 (sprot)

description: A myosin light polypeptide 6 that is encoded in the genome of human.


PROF3_HUMAN Profilin-3 (sprot)

A profilin-3 that is encoded in the genome of human.


ACTB_HUMAN Actin, cytoplasmic 1 (sprot)

An actin, cytoplasmic 1 that is encoded in the genome of human.


name: structural constituent of postsynaptic actin cytoskeleton

description: The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton.


name: positive regulation of norepinephrine uptake

description: Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell.


name: protein localization to adherens junction

description: Any process in which a protein is transported to, and/or maintained at the adherens junction.


cellular response to cytochalasin B

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus.


dense body

description: An electron dense body which may contain granules.


name: RAC3_HUMAN Ras-related C3 botulinum toxin substrate 3 (sprot)

description: A Ras-related C3 botulinum toxin substrate 3 that is encoded in the genome of human.


regulation of neuron maturation

description: Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change.


name: cerebral cortex GABAergic interneuron development

description: The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell.


name: C1QT8_HUMAN Complement C1q tumor necrosis factor-related protein 8 (sprot)

description: A complement C1q tumor necrosis factor-related protein 8 that is encoded in the genome of human.


name: IF4A1_HUMAN Eukaryotic initiation factor 4A-I (sprot)

description: A eukaryotic initiation factor 4A-I that is encoded in the genome of human.


name: ZP1_HUMAN Zona pellucida sperm-binding protein 1 (sprot)

description: A zona pellucida sperm-binding protein 1 that is encoded in the genome of human.


name: RS20_HUMAN Small ribosomal subunit protein uS10 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS10 that is encoded in the genome of human.


name: SNP25_HUMAN Synaptosomal-associated protein 25 (sprot)

description: A synaptosomal-associated protein 25 that is encoded in the genome of human.


name: exocytic insertion of neurotransmitter receptor to postsynaptic membrane

description: The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion.


name: presynaptic dense core vesicle exocytosis

description: The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels.


description: A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor.


name: extrinsic component of presynaptic membrane

description: The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex

description: A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof).


description: A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof).


name: PRPS1_HUMAN Ribose-phosphate pyrophosphokinase 1 (sprot)

description: A ribose-phosphate pyrophosphokinase 1 that is encoded in the genome of human.


name: pyrimidine nucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


hypoxanthine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate.


name: GPR85_HUMAN Probable G-protein coupled receptor 85 (sprot)

description: A probable G-protein coupled receptor 85 that is encoded in the genome of human.


name: SEM1_HUMAN 26S proteasome complex subunit SEM1 (sprot)

description: A 26S proteasome complex subunit DSS1 that is encoded in the genome of human.


name: PSA6_HUMAN Proteasome subunit alpha type-6 (sprot)

description: A proteasome subunit alpha type-6 that is encoded in the genome of human.


name: purine ribonucleoside triphosphate binding

description: Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.


S10AA_HUMAN Protein S100-A10 (sprot)

A protein S100-A10 that is encoded in the genome of human.


name: CDC42_HUMAN Cell division control protein 42 homolog (sprot)

description: A cell division control protein 42 that is encoded in the genome of human.


name: positive regulation of synapse structural plasticity

description: Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity.


actin filament branching

description: The formation of daughter actin filament branches at an angle on the sides of preexisting mother filaments.


name: regulation of modification of postsynaptic structure

description: Any process that modulates the frequency, rate or extent of modification of postsynaptic structure.


storage vacuole

description: A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules.


Golgi transport complex

description: A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8.


DEST_HUMAN Destrin (sprot)

A destrin that is encoded in the genome of human.


name: GMFB_HUMAN Glia maturation factor beta (sprot)

description: A glia maturation factor beta that is encoded in the genome of human.


name: KTDAP_HUMAN Keratinocyte differentiation-associated protein (sprot)

description: A keratinocyte differentiation-associated protein that is encoded in the genome of human.


name: RAB8A_HUMAN Ras-related protein Rab-8A (sprot)

description: A Ras-related protein Rab-8A that is encoded in the genome of human.


Golgi vesicle fusion to target membrane

description: The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane.


name: SPCS3_HUMAN Signal peptidase complex subunit 3 (sprot)

description: A signal peptidase complex subunit 3 that is encoded in the genome of human.


signal peptidase complex

description: A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space.


name: SRP54_HUMAN Signal recognition particle subunit SRP54 (sprot)

description: A signal recognition particle subunit SRP54 that is encoded in the genome of human.


name: SRP-dependent cotranslational protein targeting to membrane, translocation

description: The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.


name: RAB4B_HUMAN Ras-related protein Rab-4B (sprot)

description: A Ras-related protein Rab-4B that is encoded in the genome of human.


name: RAB2A_HUMAN Ras-related protein Rab-2A (sprot)

description: A Ras-related protein Rab-2A that is encoded in the genome of human.


name: RAB5B_HUMAN Ras-related protein Rab-5B (sprot)

description: A Ras-related protein Rab-5B that is encoded in the genome of human.


name: CKS1_HUMAN Cyclin-dependent kinases regulatory subunit 1 (sprot)

description: A cyclin-dependent kinases regulatory subunit 1 that is encoded in the genome of human.


name: RAB10_HUMAN Ras-related protein Rab-10 (sprot)

description: A Ras-related protein Rab-10 that is encoded in the genome of human.


establishment of neuroblast polarity

description: The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.


name: establishment of protein localization to endoplasmic reticulum membrane

description: The directed movement of a protein to a specific location in the endoplasmic reticulum membrane.


endoplasmic reticulum tubular network

description: A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section.


name: CXCR4_HUMAN C-X-C chemokine receptor type 4 (sprot)

description: A C-X-C chemokine receptor type 4 that is encoded in the genome of human.


name: C-X-C motif chemokine 12 receptor activity

description: Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


neuron recognition

description: The process in which a neuronal cell in a multicellular organism interprets its surroundings.


regulation of viral process

description: Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts.


name: UB2D3_HUMAN Ubiquitin-conjugating enzyme E2 D3 (sprot)

description: A ubiquitin-conjugating enzyme E2 D3 that is encoded in the genome of human.


name: UBC12_HUMAN NEDD8-conjugating enzyme Ubc12 (sprot)

description: A NEDD8-conjugating enzyme Ubc12 that is encoded in the genome of human.


NEDD8 transferase activity

description: Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.


NEDD8 conjugating enzyme activity

description: Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue.


protein neddylation

description: Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.


name: UBE2K_HUMAN Ubiquitin-conjugating enzyme E2 K (sprot)

description: A ubiquitin-conjugating enzyme E2 K that is encoded in the genome of human.


name: UBE2N_HUMAN Ubiquitin-conjugating enzyme E2 N (sprot)

description: A ubiquitin-conjugating enzyme E2 N that is encoded in the genome of human.


ubiquitin conjugating enzyme complex

description: Any complex that possesses ubiquitin conjugating enzyme activity.


UBC13-MMS2 complex

description: A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains. In Saccharomyces cerevisiae, the complex comprises Ubc13p and Mms2p; in human it comprises UBE2N and UBE2V1/UBE2V2; and in plants UBC35/UBC36 and UEV1A/UEV1B/UEV1C/UEV1D-4.


name: RAB14_HUMAN Ras-related protein Rab-14 (sprot)

description: A Ras-related protein Rab-14 that is encoded in the genome of human.


name: nuclear outer membrane-endoplasmic reticulum membrane network

description: The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane.


name: ZC3H6_HUMAN Zinc finger CCCH domain-containing protein 6 (sprot)

description: A zinc finger CCCH domain-containing protein 6 that is encoded in the genome of human.


name: ARP3_HUMAN Actin-related protein 3 (sprot)

description: An actin-related protein 3 that is encoded in the genome of human.


asymmetric cell division

description: The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.


name: meiotic chromosome movement towards spindle pole

description: The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis.


meiotic cytokinesis

description: A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells.


name: ARP2_HUMAN Actin-related protein 2 (sprot)

description: An actin-related protein 2 that is encoded in the genome of human.


ACTZ_HUMAN Alpha-centractin (sprot)

An alpha-centractin that is encoded in the genome of human.


name: TM258_HUMAN Transmembrane protein 258 (sprot)

description: A transmembrane protein 258 that is encoded in the genome of human.


description: Binding to an oligosaccharyltransferase complex.


oligosaccharyltransferase I complex

description: An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes.


name: CSN2_HUMAN COP9 signalosome complex subunit 2 (sprot)

description: A COP9 signalosome complex subunit 2 that is encoded in the genome of human.


regulation of protein neddylation

description: Any process that modulates the frequency, rate or extent of protein neddylation.


name: ARF3_HUMAN ADP-ribosylation factor 3 (sprot)

description: An ADP-ribosylation factor 3 that is encoded in the genome of human.


name: RPAB2_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC2 (sprot)

description: A DNA-directed RNA polymerases I, II, and III subunit RPABC2 that is encoded in the genome of human.


name: ABCE1_HUMAN ATP-binding cassette sub-family E member 1 (sprot)

description: An ATP-binding cassette sub-family E member 1 that is encoded in the genome of human.


name: RAP1B_HUMAN Ras-related protein Rap-1b (sprot)

description: A Ras-related protein Rap-1b that is encoded in the genome of human.


regulation of cell junction assembly

description: Any process that modulates the frequency, rate or extent of cell junction assembly.


name: RAP2B_HUMAN Ras-related protein Rap-2b (sprot)

description: A Ras-related protein Rap-2b that is encoded in the genome of human.


name: YPEL3_HUMAN Protein yippee-like 3 (sprot)

description: A protein yippee-like 3 that is encoded in the genome of human.


MAX_HUMAN Protein max (sprot)

A protein max that is encoded in the genome of human.


Mad-Max complex

description: A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max.


name: RS3A_HUMAN Small ribosomal subunit protein eS1 (sprot)

description: A small ribosomal subunit protein eS1 that is encoded in the genome of human.


name: RL26_HUMAN Large ribosomal subunit protein uL24 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL24 that is encoded in the genome of human.


name: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

description: Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.


name: regulation of translation involved in cellular response to UV

description: Any regulation of translation that is involved in cellular response to UV.


STX1B_HUMAN Syntaxin-1B (sprot)

A syntaxin-1B that is encoded in the genome of human.


regulation of synaptic vesicle priming

description: Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.


name: negative regulation of synaptic vesicle recycling

description: Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle recycling.


name: positive regulation of spontaneous neurotransmitter secretion

description: Any process that activates or increases the frequency, rate or extent of spontaneous neurotransmitter secretion.


negative regulation of macropinocytosis

description: Any process that stops, prevents or reduces the frequency, rate or extent of macropinocytosis.


SMS_HUMAN Somatostatin (sprot)

A somatostatin that is encoded in the genome of human.


name: PSME3_HUMAN Proteasome activator complex subunit 3 (sprot)

description: A proteasome activator complex subunit 3 that is encoded in the genome of human.


proteasome activator complex

description: A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex.


name: HAND2_HUMAN Heart- and neural crest derivatives-expressed protein 2 (sprot)

description: A heart- and neural crest derivatives-expressed protein 2 that is encoded in the genome of human.


name: cardiac neural crest cell development involved in outflow tract morphogenesis

description: The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract.


name: cell proliferation involved in outflow tract morphogenesis

description: The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract.


primary palate development

description: The process whose specific outcome is the progression of a primary palate over time, from its formation to the mature structure.


name: positive regulation of semaphorin-plexin signaling pathway

description: Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway.


name: RL15_HUMAN Large ribosomal subunit protein eL15 (sprot)

description: A large ribosomal subunit protein eL15 that is encoded in the genome of human.


name: MGN_HUMAN Protein mago nashi homolog (sprot)

description: A protein mago nashi that is encoded in the genome of human.


exon-exon junction subcomplex mago-y14

description: Component of the core exon-exon-junction complex (EJC). Fairly conserved in eukaryotes; in Drosophila, consists of the Mago and Y14 (tsunagi) gene products. Important for coupling nuclear and cytoplasmic events in gene expression. Inhibits the ATPase activity of eIF4AIII (Q9VHS8) to ensure a stable association of the EJC core with the mRNA.


name: FGF12_HUMAN Fibroblast growth factor 12 (sprot)

description: A fibroblast growth factor 12 that is encoded in the genome of human.


name: regulation of voltage-gated sodium channel activity

description: Any process that modulates the frequency, rate or extent of voltage-gated sodium channel activity.


name: RL27_HUMAN Large ribosomal subunit protein eL27 (sprot)

description: A large ribosomal subunit protein eL27 that is encoded in the genome of human.


OSTN_HUMAN Osteocrin (sprot)

An osteocrin that is encoded in the genome of human.


name: ISL1_HUMAN Insulin gene enhancer protein ISL-1 (sprot)

description: An insulin gene enhancer protein ISL-1 that is encoded in the genome of human.


visceral motor neuron differentiation

description: The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.


sensory system development

description: The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure.


cardiac cell fate determination

description: The process involved in cardiac cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.


name: positive regulation of macrophage colony-stimulating factor production

description: Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor production.


name: VA0D1_HUMAN V-type proton ATPase subunit d 1 (sprot)

description: A V-type proton ATPase subunit d 1 that is encoded in the genome of human.


name: PHS_HUMAN Pterin-4-alpha-carbinolamine dehydratase (sprot)

description: A pterin-4-alpha-carbinolamine dehydratase that is encoded in the genome of human.


name: RL37A_HUMAN Large ribosomal subunit protein eL43 (sprot)

description: A large ribosomal subunit protein eL43 that is encoded in the genome of human.


name: ENVT1_HUMAN Endogenous retrovirus group S71 member 1 Env polyprotein (sprot)

description: A protein that is a translation product of the ERVS71-1 gene in human.


name: ENK21_HUMAN Endogenous retrovirus group K member 21 Env polyprotein (sprot)


name: ENK24_HUMAN Endogenous retrovirus group K member 24 Env polyprotein (sprot)


name: ENK7_HUMAN Endogenous retrovirus group K member 7 Env polyprotein (sprot)


name: ENK25_HUMAN Endogenous retrovirus group K member 25 Env polyprotein (sprot)


name: REC21_HUMAN Endogenous retrovirus group K member 21 Rec protein (sprot)


name: REC19_HUMAN Endogenous retrovirus group K member 19 Rec protein (sprot)


name: REC9_HUMAN Endogenous retrovirus group K member 9 Rec protein (sprot)


name: RE113_HUMAN Endogenous retrovirus group K member 113 Rec protein (sprot)


name: RECK8_HUMAN Endogenous retrovirus group K member 8 Rec protein (sprot)


name: REC04_HUMAN Endogenous retrovirus group K member 104 Rec protein (sprot)


name: REC16_HUMAN Endogenous retrovirus group K member 16 Rec protein (sprot)

description: A protein that is a translation product of the ERVK-16 gene in human.


name: ERK25_HUMAN Endogenous retrovirus group K member 25 Rec protein (sprot)


name: NP10_HUMAN Endogenous retrovirus group K member 10 Np9 protein (sprot)


name: NP24_HUMAN Endogenous retrovirus group K member 24 Np9 protein (sprot)


name: NP7_HUMAN Endogenous retrovirus group K member 7 Np9 protein (sprot)


name: NP5_HUMAN Endogenous retrovirus group K member 5 Np9 protein (sprot)


name: RHOA_HUMAN Transforming protein RhoA (sprot)

description: A GTP-binding protein RhoA that is encoded in the genome of human.


endothelial tube lumen extension

description: Any endothelial tube morphogenesis process by which the tube is increased in length.


name: angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure

description: The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream.


alpha-beta T cell lineage commitment

description: The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell.


cleavage furrow formation

description: Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.


bone trabecula morphogenesis

description: The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod.


mitotic cleavage furrow formation

description: Any cleavage furrow formation that is involved in mitotic cell cycle.


name: positive regulation of vascular associated smooth muscle contraction

description: Any process that activates or increases the frequency, rate or extent of vascular smooth muscle contraction.


name: regulation of modification of postsynaptic actin cytoskeleton

description: Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton.


name: RND3_HUMAN Rho-related GTP-binding protein RhoE (sprot)

description: A Rho-related GTP-binding protein RhoE that is encoded in the genome of human.


name: NAA20_HUMAN N-alpha-acetyltransferase 20 (sprot)

description: An N-alpha-acetyltransferase 20 that is encoded in the genome of human.


name: N-terminal peptidyl-aspartic acid acetylation

description: The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase.


description: The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable.


name: N-terminal peptidyl-glutamic acid acetylation

description: The acetylation of the N-terminal glutamic acid of proteins to form the derivate acetyl-glutamic acid.


NatB complex

description: A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p.


NCALD_HUMAN Neurocalcin-delta (sprot)

A neurocalcin-delta that is encoded in the genome of human.


name: CH10_HUMAN 10 kDa heat shock protein, mitochondrial (sprot)

description: A 10 kDa heat shock protein, mitochondrial that is encoded in the genome of human.


name: S61A1_HUMAN Protein transport protein Sec61 subunit alpha isoform 1 (sprot)

description: A protein transport protein Sec61 subunit alpha isoform 1 that is encoded in the genome of human.


pronephric nephron development

description: The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros.


LYSC_HUMAN Lysozyme C (sprot)

A lysozyme C that is encoded in the genome of human.


lysozyme activity

description: Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan.


name: SIA8F_HUMAN Alpha-2,8-sialyltransferase 8F (sprot)

description: An alpha-2,8-sialyltransferase 8F that is encoded in the genome of human.


glycolipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).


PFD3_HUMAN Prefoldin subunit 3 (sprot)

A prefoldin subunit 3 that is encoded in the genome of human.


name: STXB1_HUMAN Syntaxin-binding protein 1 (sprot)

description: A syntaxin-binding protein 1 that is encoded in the genome of human.


positive regulation of vesicle docking

description: Any process that activates or increases the frequency, rate or extent of vesicle docking.


name: regulation of acrosomal vesicle exocytosis

description: Any process that modulates the frequency, rate or extent of acrosomal vesicle exocytosis.


B2MG_HUMAN Beta-2-microglobulin (sprot)

A beta-2-microglobulin that is encoded in the genome of human.


name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

description: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.


cellular response to iron(III) ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus.


name: positive regulation of ferrous iron binding

description: Any process that activates or increases the frequency, rate or extent of ferrous iron binding.


name: positive regulation of transferrin receptor binding

description: Any process that activates or increases the frequency, rate or extent of transferrin receptor binding.


name: negative regulation of forebrain neuron differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation.


name: DAD1_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (sprot)

description: A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 that is encoded in the genome of human.


name: TGFB2_HUMAN Transforming growth factor beta-2 proprotein (sprot)

description: A TGF-beta 2 that is encoded in the genome of human.


name: regulation of transforming growth factor beta2 production

description: Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2.


ascending aorta morphogenesis

description: The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.


regulation of timing of catagen

description: Any process that modulates the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle.


name: regulation of apoptotic process involved in outflow tract morphogenesis

description: Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.


name: negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

description: Any process that stops, prevents or reduces the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation.


name: NPC2_HUMAN NPC intracellular cholesterol transporter 2 (sprot)

description: An NPC intracellular cholesterol transporter 2 that is encoded in the genome of human.


name: regulation of isoprenoid metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids.


intracellular sterol transport

description: The directed movement of sterols within cells.


name: COPZ1_HUMAN Coatomer subunit zeta-1 (sprot)

description: A coatomer subunit zeta-1 that is encoded in the genome of human.


name: IPKA_HUMAN cAMP-dependent protein kinase inhibitor alpha (sprot)

description: A cAMP-dependent protein kinase inhibitor alpha that is encoded in the genome of human.


name: negative regulation of cAMP-dependent protein kinase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.


name: RL37_HUMAN Large ribosomal subunit protein eL37 (sprot)

description: A large ribosomal subunit protein eL37 that is encoded in the genome of human.


name: GBG11_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (sprot)

description: A guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 that is encoded in the genome of human.


name: SUMO2_HUMAN Small ubiquitin-related modifier 2 (sprot)

description: A small ubiquitin-related modifier 2 that is encoded in the genome of human.


name: UFM1_HUMAN Ubiquitin-fold modifier 1 (sprot)

description: A ubiquitin-fold modifier 1 that is encoded in the genome of human.


name: DCAF7_HUMAN DDB1- and CUL4-associated factor 7 (sprot)

description: A DDB1- and CUL4-associated factor 7 that is encoded in the genome of human.


Cul4-RING E3 ubiquitin ligase complex

description: A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.


name: WDR5_HUMAN WD repeat-containing protein 5 (sprot)

description: A WD repeat-containing protein 5 that is encoded in the genome of human.


name: AP1S1_HUMAN AP-1 complex subunit sigma-1A (sprot)

description: An AP-1 complex subunit sigma-1A that is encoded in the genome of human.


name: LMO4_HUMAN LIM domain transcription factor LMO4 (sprot)

description: A LIM domain transcription factor LMO4 that is encoded in the genome of human.


regulation of cell activation

description: Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.


name: NTF2_HUMAN Nuclear transport factor 2 (sprot)

description: A nuclear transport factor 2 that is encoded in the genome of human.


protein localization to nuclear pore

description: A process in which a protein is transported to, or maintained in, a nuclear pore.


name: HNRPK_HUMAN Heterogeneous nuclear ribonucleoprotein K (sprot)

description: A heterogeneous nuclear ribonucleoprotein K that is encoded in the genome of human.


name: regulation of low-density lipoprotein particle clearance

description: Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


name: regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

description: Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.


name: 1433G_HUMAN 14-3-3 protein gamma (sprot)

description: A 14-3-3 protein gamma that is encoded in the genome of human.


name: UBP46_HUMAN Ubiquitin carboxyl-terminal hydrolase 46 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 46 that is encoded in the genome of human.


name: RRAS2_HUMAN Ras-related protein R-Ras2 (sprot)

description: A Ras-related protein R-Ras2 that is encoded in the genome of human.


name: positive regulation of Schwann cell migration

description: Any process that activates or increases the frequency, rate or extent of Schwann cell migration.


name: TIM10_HUMAN Mitochondrial import inner membrane translocase subunit Tim10 (sprot)

description: A mitochondrial import inner membrane translocase subunit Tim10 that is encoded in the genome of human.


name: TIM22 mitochondrial import inner membrane insertion complex

description: A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12.


TSN5_HUMAN Tetraspanin-5 (sprot)

A tetraspanin-5 that is encoded in the genome of human.


name: RS7_HUMAN Small ribosomal subunit protein eS7 (sprot)

description: A small ribosomal subunit protein eS7 that is encoded in the genome of human.


name: PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (sprot)

description: A serine/threonine-protein phosphatase PP1-alpha catalytic subunit that is encoded in the genome of human.


name: PP1B_HUMAN Serine/threonine-protein phosphatase PP1-beta catalytic subunit (sprot)

description: A serine/threonine-protein phosphatase PP1-beta catalytic subunit that is encoded in the genome of human.


myosin-light-chain-phosphatase activity

description: Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate.


name: NCS1_HUMAN Neuronal calcium sensor 1 (sprot)

description: A neuronal calcium sensor 1 that is encoded in the genome of human.


name: PRS4_HUMAN 26S proteasome regulatory subunit 4 (sprot)

description: A 26S proteasome regulatory subunit 4 that is encoded in the genome of human.


name: PRS8_HUMAN 26S proteasome regulatory subunit 8 (sprot)

description: A 26S proteasome regulatory subunit 8 that is encoded in the genome of human.


name: thyrotropin-releasing hormone receptor binding

description: Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary.


name: RS8_HUMAN Small ribosomal subunit protein eS8 (sprot)

description: A small ribosomal subunit protein eS8 that is encoded in the genome of human.


name: RS15A_HUMAN Small ribosomal subunit protein uS8 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS8 that is encoded in the genome of human.


name: RS16_HUMAN Small ribosomal subunit protein uS9 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS9 that is encoded in the genome of human.


small ribosomal subunit

description: The smaller of the two subunits of a ribosome.


name: UB2G1_HUMAN Ubiquitin-conjugating enzyme E2 G1 (sprot)

description: A ubiquitin-conjugating enzyme E2 G1 that is encoded in the genome of human.


name: UBE2H_HUMAN Ubiquitin-conjugating enzyme E2 H (sprot)

description: A ubiquitin-conjugating enzyme E2 H that is encoded in the genome of human.


name: 1433E_HUMAN 14-3-3 protein epsilon (sprot)

description: A 14-3-3 protein epsilon that is encoded in the genome of human.


regulation of heart rate by hormone

description: The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.


name: negative regulation of peptidyl-serine dephosphorylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-serine dephosphorylation.


name: RS14_HUMAN Small ribosomal subunit protein uS11 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS11 that is encoded in the genome of human.


name: RS23_HUMAN Small ribosomal subunit protein uS12 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS12 that is encoded in the genome of human.


maintenance of translational fidelity

description: Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template.


name: RS18_HUMAN Small ribosomal subunit protein uS13 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS13 that is encoded in the genome of human.


name: RS29_HUMAN Small ribosomal subunit protein uS14 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS14 that is encoded in the genome of human.


name: RS13_HUMAN Small ribosomal subunit protein uS15 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS15 that is encoded in the genome of human.


name: RS11_HUMAN Small ribosomal subunit protein uS17 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS17 that is encoded in the genome of human.


name: RUXE_HUMAN Small nuclear ribonucleoprotein E (sprot)

description: A small nuclear ribonucleoprotein E that is encoded in the genome of human.


name: RUXF_HUMAN Small nuclear ribonucleoprotein F (sprot)

description: A small nuclear ribonucleoprotein F that is encoded in the genome of human.


name: RUXG_HUMAN Small nuclear ribonucleoprotein G (sprot)

description: A small nuclear ribonucleoprotein G that is encoded in the genome of human.


name: LSM3_HUMAN U6 snRNA-associated Sm-like protein LSm3 (sprot)

description: A U6 snRNA-associated Sm-like protein LSm3 that is encoded in the genome of human.


U6 snRNA 3'-end binding

description: Binding to a U6 small nuclear RNA (U6 snRNA) at the 3' end.


name: LSM6_HUMAN U6 snRNA-associated Sm-like protein LSm6 (sprot)

description: A U6 snRNA-associated Sm-like protein LSm6 that is encoded in the genome of human.


name: SMD1_HUMAN Small nuclear ribonucleoprotein Sm D1 (sprot)

description: A small nuclear ribonucleoprotein Sm D1 that is encoded in the genome of human.


name: SMD2_HUMAN Small nuclear ribonucleoprotein Sm D2 (sprot)

description: A small nuclear ribonucleoprotein Sm D2 that is encoded in the genome of human.


name: SMD3_HUMAN Small nuclear ribonucleoprotein Sm D3 (sprot)

description: A small nuclear ribonucleoprotein Sm D3 that is encoded in the genome of human.


U7 snRNA binding

description: Binding to a U7 small nuclear RNA (U7 snRNA).


BTG1_HUMAN Protein BTG1 (sprot)

A protein BTG1 that is encoded in the genome of human.


TYB4_HUMAN Thymosin beta-4 (sprot)

A thymosin beta-4 that is encoded in the genome of human.


name: positive regulation of proton-transporting ATP synthase activity, rotational mechanism

description: Any process that activates or increases the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism.


name: ARF6_HUMAN ADP-ribosylation factor 6 (sprot)

description: An ADP-ribosylation factor 6 that is encoded in the genome of human.


protein localization to endosome

description: A process in which a protein is transported to, or maintained in, a location within an endosome.


name: maintenance of postsynaptic density structure

description: A process which maintains the organization and the arrangement of proteins in the presynaptic density.


erythrocyte apoptotic process

description: Any apoptotic process in an erythrocyte.


name: PRS10_HUMAN 26S proteasome regulatory subunit 10B (sprot)

description: A 26S proteasome regulatory subunit 10B that is encoded in the genome of human.


name: SELT_HUMAN Thioredoxin reductase-like selenoprotein T (sprot)

description: A thioredoxin reductase-like selenoprotein T that is encoded in the genome of human.


name: TBPL1_HUMAN TATA box-binding protein-like 1 (sprot)

description: A TATA box-binding protein-like 1 that is encoded in the genome of human.


name: RL7A_HUMAN Large ribosomal subunit protein eL8 (sprot)

description: A large ribosomal subunit protein eL8 that is encoded in the genome of human.


name: RPB7_HUMAN DNA-directed RNA polymerase II subunit RPB7 (sprot)

description: A DNA-directed RNA polymerase II subunit RPB7 that is encoded in the genome of human.


name: RB11A_HUMAN Ras-related protein Rab-11A (sprot)

description: A Ras-related protein Rab-11A that is encoded in the genome of human.


regulation of multivesicular body size

description: Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles.


name: ERF1_HUMAN Eukaryotic peptide chain release factor subunit 1 (sprot)

description: A eukaryotic peptide chain release factor subunit 1 that is encoded in the genome of human.


aminoacyl-tRNA hydrolase activity

description: Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.


translation termination factor activity

description: Functions in the termination of translation.


name: LCN6_HUMAN Epididymal-specific lipocalin-6 (sprot)

description: An epididymal-specific lipocalin-6 that is encoded in the genome of human.


name: ERR3_HUMAN Estrogen-related receptor gamma (sprot)

description: An estrogen-related receptor gamma that is encoded in the genome of human.


AF-2 domain binding

description: Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation.


name: CNBP_HUMAN CCHC-type zinc finger nucleic acid binding protein (sprot)

description: A CCHC-type zinc finger nucleic acid binding protein that is encoded in the genome of human.


G-quadruplex DNA formation

description: A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature.


name: GAK21_HUMAN Endogenous retrovirus group K member 21 Gag polyprotein (sprot)


name: GA113_HUMAN Endogenous retrovirus group K member 113 Gag polyprotein (sprot)


name: GAK8_HUMAN Endogenous retrovirus group K member 8 Gag polyprotein (sprot)


name: YPEL5_HUMAN Protein yippee-like 5 (sprot)

description: A protein yippee-like 5 that is encoded in the genome of human.


name: RS4X_HUMAN Small ribosomal subunit protein eS4, X isoform (sprot)

description: A small ribosomal subunit protein eS4, X isoform that is encoded in the genome of human.


name: PP2AB_HUMAN Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (sprot)

description: A serine/threonine-protein phosphatase 2A catalytic subunit beta isoform that is encoded in the genome of human.


name: ACTA_HUMAN Actin, aortic smooth muscle (sprot)

description: An actin, aortic smooth muscle that is encoded in the genome of human.


name: positive regulation of hepatic stellate cell migration

description: Any process that increases the frequency, rate or extent of hepatic stellate cell migration.


name: positive regulation of hepatic stellate cell contraction

description: Any process that activates or increases the frequency, rate or extent of hepatic stellate cell contraction.


mesenchyme migration

description: The process in which the population of cells that make up a mesenchyme undergo directed movement.


name: RHOB_HUMAN Rho-related GTP-binding protein RhoB (sprot)

description: A Rho-related GTP-binding protein RhoB that is encoded in the genome of human.


name: RL23A_HUMAN Large ribosomal subunit protein uL23 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL23 that is encoded in the genome of human.


name: RS6_HUMAN Small ribosomal subunit protein eS6 (sprot)

description: A small ribosomal subunit protein eS6 that is encoded in the genome of human.


name: VISL1_HUMAN Visinin-like protein 1 (sprot)

description: A visinin-like protein 1 that is encoded in the genome of human.


H4_HUMAN Histone H4 (sprot)

A histone H4 that is encoded in the genome of human.


telomere organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins.


name: H2B1C_HUMAN Histone H2B type 1-C/E/F/G/I (sprot)

description: A histone H2B type 1-C/E/F/G/I that is encoded in the genome of human.


name: RAB1A_HUMAN Ras-related protein Rab-1A (sprot)

description: A Ras-related protein Rab-1A that is encoded in the genome of human.


name: positive regulation of glycoprotein metabolic process

description: Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process.


name: RAN_HUMAN GTP-binding nuclear protein Ran (sprot)

description: A GTP-binding nuclear protein Ran that is encoded in the genome of human.


pre-miRNA export from nucleus

description: Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product.


protein localization to nucleolus

description: A process in which a protein is transported to, or maintained in, a location within a nucleolus.


RNA nuclear export complex

description: A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore.


name: RL23_HUMAN Large ribosomal subunit protein uL14 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL14 that is encoded in the genome of human.


name: RAP1A_HUMAN Ras-related protein Rap-1A (sprot)

description: A Ras-related protein Rap-1A that is encoded in the genome of human.


name: guanyl-nucleotide exchange factor complex

description: A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.


name: UB2D2_HUMAN Ubiquitin-conjugating enzyme E2 D2 (sprot)

description: A ubiquitin-conjugating enzyme E2 D2 that is encoded in the genome of human.


name: RS15_HUMAN Small ribosomal subunit protein uS19 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS19 that is encoded in the genome of human.


name: RS24_HUMAN Small ribosomal subunit protein eS24 (sprot)

description: A small ribosomal subunit protein eS24 that is encoded in the genome of human.


name: RS25_HUMAN Small ribosomal subunit protein eS25 (sprot)

description: A small ribosomal subunit protein eS25 that is encoded in the genome of human.


name: RS26_HUMAN Small ribosomal subunit protein eS26 (sprot)

description: A small ribosomal subunit protein eS26 that is encoded in the genome of human.


name: RS28_HUMAN Small ribosomal subunit protein eS28 (sprot)

description: A small ribosomal subunit protein eS28 that is encoded in the genome of human.


name: RS30_HUMAN Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein (sprot)

description: A ubiquitin-like FUBI-ribosomal protein eS30 fusion protein that is encoded in the genome of human.


name: GBB1_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (sprot)

description: A guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 that is encoded in the genome of human.


name: RPAB5_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC5 (sprot)

description: A DNA-directed RNA polymerases I, II, and III subunit RPABC5 that is encoded in the genome of human.


name: RBX1_HUMAN E3 ubiquitin-protein ligase RBX1 (sprot)

description: An E3 ubiquitin-protein ligase RBX1 that is encoded in the genome of human.


NEDD8 ligase activity

description: Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate.


name: ubiquitin-dependent protein catabolic process via the C-end degron rule pathway

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.


name: positive regulation of protein autoubiquitination

description: Any process that activates or increases the frequency, rate or extent of protein autoubiquitination.


name: negative regulation of response to oxidative stress

description: Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress.


cullin-RING ubiquitin ligase complex

description: Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.


Cul4B-RING E3 ubiquitin ligase complex

description: A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits.


Cul7-RING ubiquitin ligase complex

description: A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein.


name: GBB2_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (sprot)

description: A guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 that is encoded in the genome of human.


name: RL30_HUMAN Large ribosomal subunit protein eL30 (sprot)

description: A large ribosomal subunit protein eL30 that is encoded in the genome of human.


name: RL39_HUMAN Large ribosomal subunit protein eL39 (sprot)

description: A large ribosomal subunit protein eL39 that is encoded in the genome of human.


name: RL31_HUMAN Large ribosomal subunit protein eL31 (sprot)

description: A large ribosomal subunit protein eL31 that is encoded in the genome of human.


name: RL10A_HUMAN Large ribosomal subunit protein uL1 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL1 that is encoded in the genome of human.


name: RL32_HUMAN Large ribosomal subunit protein eL32 (sprot)

description: A large ribosomal subunit protein eL32 that is encoded in the genome of human.


name: RL11_HUMAN Large ribosomal subunit protein uL5 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL5 that is encoded in the genome of human.


name: RL8_HUMAN Large ribosomal subunit protein uL2 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL2 that is encoded in the genome of human.


name: PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A (sprot)

description: A peptidyl-prolyl cis-trans isomerase A that is encoded in the genome of human.


cell adhesion molecule production

description: The appearance of a cell adhesion molecule due to biosynthesis or secretion.


name: negative regulation of protein K48-linked ubiquitination

description: Any process that stops, prevents or reduces the frequency, rate or extent of K48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.


negative regulation of viral life cycle

description: Any process that stops, prevents or reduces the frequency, rate or extent of viral life cycle.


name: regulation of apoptotic signaling pathway

description: Any process that modulates the frequency, rate or extent of apoptotic signaling pathway.


name: FKB1A_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1A (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP1A that is encoded in the genome of human.


macrolide binding

description: Binding to a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species.


channel regulator activity

description: Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.


signaling receptor inhibitor activity

description: Binds to and modulates the activity of a signaling receptor.


cytoplasmic side of membrane

description: The side of a membrane that faces the cytoplasm.


name: RS32_HUMAN Small ribosomal subunit protein eS32 (sprot)

description: A small ribosomal subunit protein eS32 that is encoded in the genome of human.


name: BLCAP_HUMAN Apoptosis inducing factor BLCAP (sprot)

description: A bladder cancer-associated protein that is encoded in the genome of human.


name: CCG7_HUMAN Voltage-dependent calcium channel gamma-7 subunit (sprot)

description: A voltage-dependent calcium channel gamma-7 subunit that is encoded in the genome of human.


name: RS27A_HUMAN Ubiquitin-ribosomal protein eS31 fusion protein (sprot)

description: A ubiquitin-ribosomal protein eS31 fusion protein that is encoded in the genome of human.


name: RL40_HUMAN Ubiquitin-ribosomal protein eL40 fusion protein (sprot)

description: A ubiquitin-ribosomal protein eL40 fusion protein that is encoded in the genome of human.


name: GRB2_HUMAN Growth factor receptor-bound protein 2 (sprot)

description: A growth factor receptor-bound protein 2 that is encoded in the genome of human.


name: guanyl-nucleotide exchange factor adaptor activity

description: The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.


Grb2-EGFR complex

description: A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway.


name: TRA2B_HUMAN Transformer-2 protein homolog beta (sprot)

description: A transformer-2 protein homolog beta that is encoded in the genome of human.


name: RAC1_HUMAN Ras-related C3 botulinum toxin substrate 1 (sprot)

description: A Ras-related C3 botulinum toxin substrate 1 that is encoded in the genome of human.


name: AP2B1_HUMAN AP-2 complex subunit beta (sprot)

description: An AP-2 complex subunit beta that is encoded in the genome of human.


signal sequence binding

description: Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.


name: VAMP2_HUMAN Vesicle-associated membrane protein 2 (sprot)

description: A vesicle-associated membrane protein 2 that is encoded in the genome of human.


name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex

description: A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).


name: GNAS2_HUMAN Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (sprot)

description: A guanine nucleotide-binding protein G(s) subunit alpha (human), isoforms Gnas-1, Gnas-2, 3, and 4.


name: GNAI1_HUMAN Guanine nucleotide-binding protein G(i) subunit alpha-1 (sprot)

description: A guanine nucleotide-binding protein G(i) subunit alpha-1 that is encoded in the genome of human.


D2 dopamine receptor binding

description: Binding to a D2 dopamine receptor.


name: CANB1_HUMAN Calcineurin subunit B type 1 (sprot)

description: A calcineurin subunit B type 1 that is encoded in the genome of human.


name: 1433Z_HUMAN 14-3-3 protein zeta/delta (sprot)

description: A 14-3-3 protein zeta/delta that is encoded in the genome of human.


synaptic target recognition

description: The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.


name: VPK21_HUMAN Endogenous retrovirus group K member 21 Pro protein (sprot)


name: VPK19_HUMAN Endogenous retrovirus group K member 19 Pro protein (sprot)


name: VP113_HUMAN Endogenous retrovirus group K member 113 Pro protein (sprot)


name: VPK8_HUMAN Endogenous retrovirus group K member 8 Pro protein (sprot)


name: VPK18_HUMAN Endogenous retrovirus group K member 18 Pro protein (sprot)


name: VPK04_HUMAN Endogenous retrovirus group K member 104 Pro protein (sprot)


name: VPK25_HUMAN Endogenous retrovirus group K member 25 Pro protein (sprot)


name: GAK9_HUMAN Endogenous retrovirus group K member 9 Gag polyprotein (sprot)


name: VPK9_HUMAN Endogenous retrovirus group K member 9 Pro protein (sprot)


name: POK9_HUMAN Endogenous retrovirus group K member 9 Pol protein (sprot)


name: VPK24_HUMAN Endogenous retrovirus group K member 24 Pro protein (sprot)


name: GAK7_HUMAN Endogenous retrovirus group K member 7 Gag polyprotein (sprot)


name: VPK7_HUMAN Endogenous retrovirus group K member 7 Pro protein (sprot)


name: PO113_HUMAN Endogenous retrovirus group K member 113 Pol protein (sprot)


name: POK8_HUMAN Endogenous retrovirus group K member 8 Pol protein (sprot)


name: POK7_HUMAN Endogenous retrovirus group K member 7 Pol protein (sprot)


name: POK25_HUMAN Endogenous retrovirus group K member 25 Pol protein (sprot)


name: GAK24_HUMAN Endogenous retrovirus group K member 24 Gag polyprotein (sprot)


name: UBE2B_HUMAN Ubiquitin-conjugating enzyme E2 B (sprot)

description: A ubiquitin-conjugating enzyme E2 B that is encoded in the genome of human.


name: positive regulation of reciprocal meiotic recombination

description: Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.


chiasma assembly

description: The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids.


synaptonemal complex organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis.


name: 2ABA_HUMAN Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (sprot)

description: A serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform that is encoded in the genome of human.


name: RSMN_HUMAN Small nuclear ribonucleoprotein-associated protein N (sprot)

description: A small nuclear ribonucleoprotein-associated protein N that is encoded in the genome of human.


name: SUMO1_HUMAN Small ubiquitin-related modifier 1 (sprot)

description: A small ubiquitin-related modifier 1 that is encoded in the genome of human.


small protein activating enzyme binding

description: Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme.


name: DYL1_HUMAN Dynein light chain 1, cytoplasmic (sprot)

description: A dynein light chain 1, cytoplasmic that is encoded in the genome of human.


name: negative regulation of DNA strand resection involved in replication fork processing

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA strand resection involved in replication fork processing.


name: DYLT1_HUMAN Dynein light chain Tctex-type 1 (sprot)

description: A dynein light chain Tctex-type 1 that is encoded in the genome of human.


name: microtubule-dependent intracellular transport of viral material towards nucleus

description: The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules.


name: RL38_HUMAN Large ribosomal subunit protein eL38 (sprot)

description: A large ribosomal subunit protein eL38 that is encoded in the genome of human.


90S preribosome assembly

description: The aggregation, arrangement and bonding together of proteins and RNA molecules to form a 90S preribosome. The 90S preribosome represents the complex that forms on the primary rRNA transcript before it splits into the small subunit and large subunit portions.


eukaryotic 80S initiation complex

description: A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region.


name: SKP1_HUMAN S-phase kinase-associated protein 1 (sprot)

description: An S-phase kinase-associated protein 1A that is encoded in the genome of human.


name: ubiquitin ligase complex scaffold activity

description: The binding activity of a molecule that brings together an ubiquitin ligase and an ubiquitin ligase-substrate adaptor, permitting those molecules to function in a coordinated way.


name: GBG1_HUMAN Guanine nucleotide-binding protein G(T) subunit gamma-T1 (sprot)

description: A guanine nucleotide-binding protein G(T) subunit gamma-T1 that is encoded in the genome of human.


name: GBG3_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 (sprot)

description: A guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 that is encoded in the genome of human.


name: GBG5_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 (sprot)

description: A guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 that is encoded in the genome of human.


name: positive regulation of secondary heart field cardioblast proliferation

description: Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).


name: RS21_HUMAN Small ribosomal subunit protein eS21 (sprot)

description: A small ribosomal subunit protein eS21 that is encoded in the genome of human.


name: IF5A1_HUMAN Eukaryotic translation initiation factor 5A-1 (sprot)

description: A eukaryotic translation initiation factor 5A-1 that is encoded in the genome of human.


name: positive regulation of translational elongation

description: Any process that activates or increases the frequency, rate or extent of translational elongation.


name: positive regulation of translational termination

description: Any process that activates or increases the frequency, rate or extent of translational termination.


name: RACK1_HUMAN Small ribosomal subunit protein RACK1 (sprot)

description: A small ribosomal subunit protein RACK1 that is encoded in the genome of human.


name: negative regulation of endoplasmic reticulum unfolded protein response

description: Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response.


name: negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide

description: Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide.


name: KCNJ2_HUMAN Inward rectifier potassium channel 2 (sprot)

description: An inward rectifier potassium channel 2 that is encoded in the genome of human.


name: regulation of skeletal muscle contraction via regulation of action potential

description: Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes.


magnesium ion transport

description: The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


ACTG_HUMAN Actin, cytoplasmic 2 (sprot)

An actin, cytoplasmic 2 that is encoded in the genome of human.


basal body patch

description: The region in the apical portion of multiciliated epithelial cells where the ciliary basal bodies cluster.


name: ACTH_HUMAN Actin, gamma-enteric smooth muscle (sprot)

description: An actin, gamma-enteric smooth muscle that is encoded in the genome of human.


name: SPT4H_HUMAN Transcription elongation factor SPT4 (sprot)

description: A transcription elongation factor SPT4 that is encoded in the genome of human.


name: UBC9_HUMAN SUMO-conjugating enzyme UBC9 (sprot)

description: A SUMO-conjugating enzyme UBC9 that is encoded in the genome of human.


SUMO conjugating enzyme activity

description: Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue.


name: positive regulation of SUMO transferase activity

description: Any process that activates or increases the frequency, rate or extent of SUMO transferase activity.


SELW_HUMAN Selenoprotein W (sprot)

A selenoprotein W that is encoded in the genome of human.


TYB10_HUMAN Thymosin beta-10 (sprot)

A thymosin beta-10 that is encoded in the genome of human.


name: TNNC1_HUMAN Troponin C, slow skeletal and cardiac muscles (sprot)

description: A troponin C, slow skeletal and cardiac muscles that is encoded in the genome of human.


name: regulation of muscle filament sliding speed

description: Any process that modulates the velocity of muscle filament sliding.


name: PP2AA_HUMAN Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (sprot)

description: A serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform that is encoded in the genome of human.


name: YBOX1_HUMAN Y-box-binding protein 1 (sprot)

description: A Y-box-binding protein 1 that is encoded in the genome of human.


name: C5-methylcytidine-containing RNA reader activity

description: A protein adaptor that recognizes and binds an RNA molecule modified by C5-methylcytidine.


tRNA transport

description: The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: SC11A_HUMAN Signal peptidase complex catalytic subunit SEC11A (sprot)

description: A signal peptidase complex catalytic subunit SEC11A that is encoded in the genome of human.


name: CSK2B_HUMAN Casein kinase II subunit beta (sprot)

description: A casein kinase II subunit beta that is encoded in the genome of human.


name: symbiont-mediated disruption of host cell PML body

description: The process in which an organism effects a change that impairs the structure or function of the host PML body. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: TPM4_HUMAN Tropomyosin alpha-4 chain (sprot)

description: A tropomyosin alpha-4 chain that is encoded in the genome of human.


name: ACTC_HUMAN Actin, alpha cardiac muscle 1 (sprot)

description: An actin, alpha cardiac muscle 1 that is encoded in the genome of human.


actin-myosin filament sliding

description: The sliding movement of actin thin filaments and myosin thick filaments past each other.


name: UB2L3_HUMAN Ubiquitin-conjugating enzyme E2 L3 (sprot)

description: A ubiquitin-conjugating enzyme E2 L3 that is encoded in the genome of human.


name: EF1A1_HUMAN Elongation factor 1-alpha 1 (sprot)

description: An elongation factor 1-alpha 1 that is encoded in the genome of human.


name: regulation of D-erythro-sphingosine kinase activity

description: Any process that modulates the frequency, rate or extent of D-erythro-sphingosine kinase activity.


name: FKB1B_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1B (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP1B that is encoded in the genome of human.


name: positive regulation of sequestering of calcium ion

description: Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.


name: ACTS_HUMAN Actin, alpha skeletal muscle (sprot)

description: An actin, alpha skeletal muscle that is encoded in the genome of human.


name: TBA1B_HUMAN Tubulin alpha-1B chain (sprot)

description: A tubulin alpha-1B chain that is encoded in the genome of human.


name: TBA4A_HUMAN Tubulin alpha-4A chain (sprot)

description: A tubulin alpha-4A chain that is encoded in the genome of human.


name: TBB4B_HUMAN Tubulin beta-4B chain (sprot)

description: A tubulin beta-4B chain that is encoded in the genome of human.


name: CSK21_HUMAN Casein kinase II subunit alpha (sprot)

description: A casein kinase II subunit alpha that is encoded in the genome of human.


name: PA1B2_HUMAN Platelet-activating factor acetylhydrolase IB subunit alpha2 (sprot)

description: A platelet-activating factor acetylhydrolase IB subunit alpha2 that is encoded in the genome of human.


H31_HUMAN Histone H3.1 (sprot)

A histone H3 that is a translation product of any of the following genes in human: HIST1H3A/HIST1H3B/HIST1H3C/HIST1H3D/HIST1H3E/HIST1H3F/HIST1H3G/HIST1H3H/HIST1H3I/HIST1H3J.


name: UBX2A_HUMAN UBX domain-containing protein 2A (sprot)

description: A UBX domain-containing protein 2A that is encoded in the genome of human.


name: HBB_HUMAN Hemoglobin subunit beta (sprot)

description: A hemoglobin subunit beta that is encoded in the genome of human.


haptoglobin binding

description: Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex.


name: NOMO3_HUMAN BOS complex subunit NOMO3 (sprot)

description: A BOS complex subunit NOMO3 that is encoded in the genome of human.


name: multi-pass transmembrane protein insertion into ER membrane

description: A process of protein insertion of multi-pass membrane proteins into the endoplasmic reticulum (ER) membrane. Insertion of multi-pass membrane proteins is mediated by the multi-pass translocon complex and takes place following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex to promote insertion of subsequent transmembrane regions.


name: negative regulation of nodal signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway.


multi-pass translocon complex

description: A protein complex that mediates the insertion of multi-pass transmembrane proteins into endoplasmic reticulum (ER) membrane. Substrates enter via the lateral gate of the Sec61 translocon. The complex comprises the GEL subcomplex (composed of RAB5IF/OPTI and TMCO1), the BOS subcomplex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT subcomplex (composed of WDR83OS/Asterix and CCDC47).


name: HBG1_HUMAN Hemoglobin subunit gamma-1 (sprot)

description: A hemoglobin subunit gamma-1 that is encoded in the genome of human.


name: HBG2_HUMAN Hemoglobin subunit gamma-2 (sprot)

description: A hemoglobin subunit gamma-2 that is encoded in the genome of human.


name: HBA_HUMAN Hemoglobin subunit alpha (sprot)

description: A hemoglobin subunit alpha that is encoded in the genome of human.


name: CXAR_HUMAN Coxsackievirus and adenovirus receptor (sprot)

description: A coxsackievirus and adenovirus receptor that is encoded in the genome of human.


name: cell adhesive protein binding involved in AV node cell-bundle of His cell communication

description: Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells.


name: AV node cell to bundle of His cell communication

description: The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


name: AV node cell-bundle of His cell adhesion involved in cell communication

description: The attachment of an AV node cell to an bundle of His cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate.


name: 3BP2_HUMAN SH3 domain-binding protein 2 (sprot)

description: An SH3 domain-binding protein 2 that is encoded in the genome of human.


name: NOP14_HUMAN Nucleolar protein 14 (sprot)

description: A nucleolar protein 14 that is encoded in the genome of human.


Noc4p-Nop14p complex

description: A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis.


name: RNF4_HUMAN E3 ubiquitin-protein ligase RNF4 (sprot)

description: An E3 ubiquitin-protein ligase RNF4 that is encoded in the genome of human.


regulation of spindle assembly

description: Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.


regulation of kinetochore assembly

description: Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.


name: IGBP1_HUMAN Immunoglobulin-binding protein 1 (sprot)

description: An immunoglobulin-binding protein 1 that is encoded in the genome of human.


name: SHPS1_HUMAN Tyrosine-protein phosphatase non-receptor type substrate 1 (sprot)

description: A tyrosine-protein phosphatase non-receptor type substrate 1 that is encoded in the genome of human.


cell-cell adhesion mediator activity

description: The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell.


cellular response to interleukin-12

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus.


name: negative regulation of I-kappaB phosphorylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of I-kappaB phosphorylation.


name: ADAM8_HUMAN Disintegrin and metalloproteinase domain-containing protein 8 (sprot)

description: A disintegrin and metalloproteinase domain-containing protein 8 that is encoded in the genome of human.


name: positive regulation of fibronectin-dependent thymocyte migration

description: Any process that activates or increases the frequency, rate or extent of fibronectin-dependent thymocyte migration.


dense core granule membrane

description: The lipid bilayer surrounding a dense core granule.


CP4F2_HUMAN Cytochrome P450 4F2 (sprot)

A cytochrome P450 4F2 that is encoded in the genome of human.


alkane 1-monooxygenase activity

description: Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O.


description: Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase].


name: arachidonic acid omega-hydroxylase activity

description: Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid.


description: Catalysis of the reaction: (+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-alpha-tocopherol + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


name: 20-hydroxy-leukotriene B4 omega oxidase activity

description: Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase].


name: 20-aldehyde-leukotriene B4 20-monooxygenase activity

description: Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase].


pressure natriuresis

description: The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis).


name: negative regulation of icosanoid secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell.


name: positive regulation of icosanoid secretion

description: Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell.


leukotriene B4 catabolic process

description: The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.


menaquinone catabolic process

description: The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2.


vitamin K catabolic process

description: The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals.


name: SERB_HUMAN Phosphoserine phosphatase (sprot)

description: A phosphoserine phosphatase that is encoded in the genome of human.


L-phosphoserine phosphatase activity

description: Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid.


name: RBM6_HUMAN RNA-binding protein 6 (sprot)

description: An RNA-binding protein 6 that is encoded in the genome of human.


GPC5_HUMAN Glypican-5 (sprot)

A glypican-5 that is encoded in the genome of human.


name: GBRE_HUMAN Gamma-aminobutyric acid receptor subunit epsilon (sprot)

description: A gamma-aminobutyric acid receptor subunit epsilon that is encoded in the genome of human.


name: negative regulation of chloride transport

description: Any process that stops, prevents or reduces the frequency, rate or extent of chloride transport.


name: PITX1_HUMAN Pituitary homeobox 1 (sprot)

description: A pituitary homeobox 1 that is encoded in the genome of human.


myoblast fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


name: IF4G2_HUMAN Eukaryotic translation initiation factor 4 gamma 2 (sprot)

description: A eukaryotic translation initiation factor 4 gamma 2 that is encoded in the genome of human.


name: RPP38_HUMAN Ribonuclease P protein subunit p38 (sprot)

description: A ribonuclease P protein subunit p38 that is encoded in the genome of human.


name: RPP30_HUMAN Ribonuclease P protein subunit p30 (sprot)

description: A ribonuclease P protein subunit p30 that is encoded in the genome of human.


name: GTF2I_HUMAN General transcription factor II-I (sprot)

description: A general transcription factor II-I that is encoded in the genome of human.


name: ASIC1_HUMAN Acid-sensing ion channel 1 (sprot)

description: An acid-sensing ion channel 1 that is encoded in the genome of human.


monoatomic ion-gated channel activity

description: Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus.


name: pH-gated monoatomic ion channel activity

description: Enables the transmembrane transfer of an inorganic ion by a channel that opens in response to a change in proton concentration (pH).


name: DLG4_HUMAN Disks large homolog 4 (sprot)

description: A disks large homolog 4 that is encoded in the genome of human.


beta-1 adrenergic receptor binding

description: Binding to a beta-1 adrenergic receptor.


P2Y1 nucleotide receptor binding

description: Binding to a P2Y1 nucleotide receptor.


name: PI42B_HUMAN Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (sprot)

description: A phosphatidylinositol 5-phosphate 4-kinase type-2 beta that is encoded in the genome of human.


name: CNTP1_HUMAN Contactin-associated protein 1 (sprot)

description: A contactin-associated protein 1 that is encoded in the genome of human.


name: protein localization to juxtaparanode region of axon

description: Any process in which a protein is transported to, or maintained at, the juxtaparanode region of an axon.


postsynaptic density organization

description: A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.


name: neuromuscular junction development, skeletal muscle fiber

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction that targets a skeletal muscle fiber.