diapedesis

description: The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation.


name: negative regulation of protein homodimerization activity

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.


name: clathrin-dependent extracellular exosome endocytosis

description: The clathrin-mediated endocytosis of an extracellular exosome.


integrin alpha4-beta7 complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An integrin complex that comprises one alpha4 subunit and one beta7 subunit.


name: RARG_HUMAN Retinoic acid receptor gamma (sprot)

description: A retinoic acid receptor gamma that is encoded in the genome of human.


name: growth plate cartilage chondrocyte growth

description: The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another.


name: regulation of myeloid cell differentiation

description: Any process that modulates the frequency, rate or extent of myeloid cell differentiation.


name: AT1A3_HUMAN Sodium/potassium-transporting ATPase subunit alpha-3 (sprot)

description: A sodium/potassium-transporting ATPase subunit alpha-3 that is encoded in the genome of human.


EF2_HUMAN Elongation factor 2 (sprot)

An elongation factor 2 that is encoded in the genome of human.


MT1G_HUMAN Metallothionein-1G (sprot)

A metallothionein-1G that is encoded in the genome of human.


name: K1C10_HUMAN Keratin, type I cytoskeletal 10 (sprot)

description: A keratin, type I cytoskeletal 10 that is encoded in the genome of human.


name: K1C13_HUMAN Keratin, type I cytoskeletal 13 (sprot)

description: A keratin, type I cytoskeletal 13 that is encoded in the genome of human.


name: regulation of translation in response to stress

description: Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


name: K2C5_HUMAN Keratin, type II cytoskeletal 5 (sprot)

description: A keratin, type II cytoskeletal 5 that is encoded in the genome of human.


intermediate filament polymerization

description: Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain.


name: PDIA4_HUMAN Protein disulfide-isomerase A4 (sprot)

description: A protein disulfide-isomerase A4 that is encoded in the genome of human.


name: CO6_HUMAN Complement component C6 (sprot)

description: A complement component C6 that is encoded in the genome of human.


name: P4HA1_HUMAN Prolyl 4-hydroxylase subunit alpha-1 (sprot)

description: A prolyl 4-hydroxylase subunit alpha-1 that is encoded in the genome of human.


name: ZNF35_HUMAN Zinc finger protein 35 (sprot)

description: A zinc finger protein 35 that is encoded in the genome of human.


name: PPA5_HUMAN Tartrate-resistant acid phosphatase type 5 (sprot)

description: A tartrate-resistant acid phosphatase type 5 that is encoded in the genome of human.


name: negative regulation of superoxide anion generation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell.


name: CEAM1_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 1 (sprot)

description: A carcinoembryonic antigen-related cell adhesion molecule 1 that is encoded in the genome of human.


name: regulation of endothelial cell migration

description: Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.


name: negative regulation of interleukin-1 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production.


insulin receptor internalization

description: A receptor-mediated endocytosis process that results in the movement of an insulin receptor from the plasma membrane to the inside of the cell.


name: negative regulation of cytotoxic T cell degranulation

description: Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation.


name: regulation of endothelial cell differentiation

description: Any process that modulates the frequency, rate or extent of endothelial cell differentiation.


name: negative regulation of lipid biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.


regulation of homophilic cell adhesion

description: Any process that modulates the frequency, rate or extent of homophilic cell adhesion.


name: negative regulation of hepatocyte proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation.


name: TCTP_HUMAN Translationally-controlled tumor protein (sprot)

description: A translationally-controlled tumor protein that is encoded in the genome of human.


name: HEM2_HUMAN Delta-aminolevulinic acid dehydratase (sprot)

description: A delta-aminolevulinic acid dehydratase that is encoded in the genome of human.


porphobilinogen synthase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen.


proteasome core complex binding

description: Binding to a proteasome core complex.


response to aluminum ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus.


response to vitamin B1

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus.


response to cobalt ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion (Co2+) stimulus.


response to methylmercury

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus.


ONCM_HUMAN Oncostatin-M (sprot)

An oncostatin-M that is encoded in the genome of human.


oncostatin-M receptor binding

description: Binding to an oncostatin-M receptor.


oncostatin-M-mediated signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by oncostatin-M (OSM) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. OSM can signal via at least two different receptors (a specific receptor and a LIF receptor) to activate different downstream signal transduction pathways.


TF_HUMAN Tissue factor (sprot)

A tissue factor that is encoded in the genome of human.


name: activation of plasma proteins involved in acute inflammatory response

description: Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.


name: activation of blood coagulation via clotting cascade

description: Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot.


name: PRG2_HUMAN Bone marrow proteoglycan (sprot)

description: A bone marrow proteoglycan that is encoded in the genome of human.


name: HLAE_HUMAN HLA class I histocompatibility antigen, alpha chain E (sprot)

description: An MHC class I histocompatibility antigen, alpha chain E that is encoded in the genome of human.


name: natural killer cell lectin-like receptor binding

description: Binding to a lectin-like natural killer cell receptor.


name: positive regulation of antibody-dependent cellular cytotoxicity

description: Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity.


name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib

description: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.


name: antigen processing and presentation of exogenous peptide antigen via MHC class Ib

description: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.


name: regulation of natural killer cell mediated immunity

description: Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity.


positive regulation of TRAIL production

description: Any process that activates or increases the frequency, rate, or extent of TRAIL production.


name: positive regulation of natural killer cell activation

description: Any process that activates or increases the frequency, rate or extent of natural killer cell activation.


MHC class Ib protein complex

description: A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.


name: DRB4_HUMAN HLA class II histocompatibility antigen, DR beta 4 chain (sprot)

description: An MHC class II histocompatibility antigen beta chain DRB4 that is encoded in the genome of human.


name: DOB_HUMAN HLA class II histocompatibility antigen, DO beta chain (sprot)

description: An MHC class II histocompatibility antigen, DO beta chain that is encoded in the genome of human.


PLSL_HUMAN Plastin-2 (sprot)

A plastin-2 that is encoded in the genome of human.


name: T cell activation involved in immune response

description: The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.


name: regulation of intracellular protein transport

description: Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.


actin crosslink formation

description: The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes.


PLST_HUMAN Plastin-3 (sprot)

A plastin-3 that is encoded in the genome of human.


name: ACPH_HUMAN Acylamino-acid-releasing enzyme (sprot)

description: An acylamino-acid-releasing enzyme that is encoded in the genome of human.


translational termination

description: The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).


name: ETFA_HUMAN Electron transfer flavoprotein subunit alpha, mitochondrial (sprot)

description: An electron transfer flavoprotein subunit alpha, mitochondrial that is encoded in the genome of human.


electron transfer flavoprotein complex

description: A protein complex facilitating the electron transfer from an acyl-CoA molecule to ubiquinone via its flavin adenine dinucleotide (FAD) cofactor. Usually contains an alpha and a beta subunit and the structural cofactor adenosine monophosphate (AMP). Part of a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the electron transport system.


name: TNNT1_HUMAN Troponin T, slow skeletal muscle (sprot)

description: A troponin T, slow skeletal muscle that is encoded in the genome of human.


name: negative regulation of muscle contraction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.


name: GYS1_HUMAN Glycogen [starch] synthase, muscle (sprot)

description: A glycogen [starch] synthase, muscle that is encoded in the genome of human.


name: glycogen synthase activity, transferring glucose-1-phosphate

description: Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate.


name: KAP2_HUMAN cAMP-dependent protein kinase type II-alpha regulatory subunit (sprot)

description: A cAMP-dependent protein kinase type II-alpha regulatory subunit that is encoded in the genome of human.


cAMP-dependent protein kinase complex

description: An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.


name: SC5A1_HUMAN Sodium/glucose cotransporter 1 (sprot)

description: A sodium/glucose cotransporter 1 that is encoded in the genome of human.


name: myo-inositol:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in).


name: water transmembrane transporter activity

description: Enables the transfer of water (H2O) from one side of a membrane to the other.


name: glucose:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in).


name: pentose transmembrane transporter activity

description: Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms.


name: fucose transmembrane transporter activity

description: Enables the transfer of fucose from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose.


name: alpha-glucoside transmembrane transporter activity

description: Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration.


name: galactose:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in).


alpha-glucoside transport

description: The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration.


pentose transmembrane transport

description: The process in which pentose is transported across a lipid bilayer, from one side of a membrane to the other. A pentose is any aldose with a chain of five carbon atoms in the molecule.


fucose transmembrane transport

description: The process in which fucose is transported across a lipid bilayer, from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose.


myo-inositol transport

description: The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms.


name: sodium ion import across plasma membrane

description: The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol.


intestinal hexose absorption

description: Uptake of hexoses, notably D-glucose, fructose, and galactose, into the blood by absorption from the small intestine.


intracellular organelle

description: Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.


ANXA8_HUMAN Annexin A8 (sprot)

An annexin A8 that is encoded in the genome of human.


name: negative regulation of serine-type endopeptidase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity.


name: negative regulation of phospholipase A2 activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase A2 activity.


ENOB_HUMAN Beta-enolase (sprot)

A beta-enolase that is encoded in the genome of human.


name: COBA2_HUMAN Collagen alpha-2(XI) chain (sprot)

description: A collagen alpha-2(XI) chain that is encoded in the genome of human.


name: ADRB3_HUMAN Beta-3 adrenergic receptor (sprot)

description: A beta-3 adrenergic receptor that is encoded in the genome of human.


beta3-adrenergic receptor activity

description: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors.


beta-3 adrenergic receptor binding

description: Binding to a beta-3 adrenergic receptor.


name: T2FB_HUMAN General transcription factor IIF subunit 2 (sprot)

description: A general transcription factor IIF subunit 2 that is encoded in the genome of human.


transcription factor TFIIF complex

description: A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation.


name: HRES1_HUMAN Putative HTLV-1-related endogenous sequence (sprot)


CD59_HUMAN CD59 glycoprotein (sprot)

A CD59 glycoprotein that is encoded in the genome of human.


name: YJU2B_HUMAN Probable splicing factor YJU2B (sprot)

description: A probable splicing factor YJU2B that is encoded in the genome of human.


name: MTDC_HUMAN Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (sprot)

description: A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial that is encoded in the genome of human.


name: 3BHS1_HUMAN 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (sprot)

description: A 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 that is encoded in the genome of human.


name: DHB1_HUMAN 17-beta-hydroxysteroid dehydrogenase type 1 (sprot)

description: A 17-beta-hydroxysteroid dehydrogenase type 1 that is encoded in the genome of human.


name: testosterone dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+.


description: Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH.


name: 17-beta-hydroxysteroid dehydrogenase (NADP+) activity

description: Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+.


estradiol binding

description: Binding to estradiol.


cellular response to metal ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.


CATE_HUMAN Cathepsin E (sprot)

A cathepsin E that is encoded in the genome of human.


name: GFAP_HUMAN Glial fibrillary acidic protein (sprot)

description: A glial fibrillary acidic protein that is encoded in the genome of human.


name: positive regulation of Schwann cell proliferation

description: Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.


Schwann cell proliferation

description: The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.


name: D-aspartate import across plasma membrane

description: The directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.


astrocyte end-foot

description: Terminal process of astrocyte abutting non-neuronal surfaces in the brain.


EDN3_HUMAN Endothelin-3 (sprot)

An endothelin-3 that is encoded in the genome of human.


intracellular magnesium ion homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of magnesium ions within a cell.


LYAM1_HUMAN L-selectin (sprot)

An L-selectin that is encoded in the genome of human.


oligosaccharide binding

description: Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.


name: MIF_HUMAN Macrophage migration inhibitory factor (sprot)

description: A macrophage migration inhibitory factor that is encoded in the genome of human.


dopachrome isomerase activity

description: Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.


phenylpyruvate tautomerase activity

description: Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate.


name: positive regulation of prostaglandin secretion involved in immune response

description: Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell and contributes to the immune response.


name: positive regulation of myeloid leukocyte cytokine production involved in immune response

description: Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response.


protein homotrimerization

description: The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.


name: FOLR2_HUMAN Folate receptor beta (sprot)

description: A folate receptor beta that is encoded in the genome of human.


folic acid receptor activity

description: Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis.


cellular response to folic acid

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus.


CD99_HUMAN CD99 antigen (sprot)

A CD99 molecule that is encoded in the genome of human.


name: HGF_HUMAN Hepatocyte growth factor (sprot)

description: A hepatocyte growth factor that is encoded in the genome of human.


PERF_HUMAN Perforin-1 (sprot)

A perforin-1 that is encoded in the genome of human.


pore-forming activity

description: An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death.


immune response to tumor cell

description: An immune system process that functions in the response of an organism to a tumor cell.


name: GLU2B_HUMAN Glucosidase 2 subunit beta (sprot)

description: A glucosidase 2 subunit beta that is encoded in the genome of human.


glucosidase II complex

description: A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins.


name: IRF2_HUMAN Interferon regulatory factor 2 (sprot)

description: An interferon regulatory factor 2 that is encoded in the genome of human.


name: HCLS1_HUMAN Hematopoietic lineage cell-specific protein (sprot)

description: A hematopoietic lineage cell-specific protein that is encoded in the genome of human.


nuclear transport

description: The directed movement of substances into, out of, or within the nucleus.


name: negative regulation of leukocyte apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process.


name: FPPS_HUMAN Farnesyl pyrophosphate synthase (sprot)

description: A farnesyl pyrophosphate synthase that is encoded in the genome of human.


name: TRI27_HUMAN Zinc finger protein RFP (sprot)

description: A zinc finger protein RFP that is encoded in the genome of human.


name: negative regulation of adaptive immune response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.


CBPM_HUMAN Carboxypeptidase M (sprot)

A carboxypeptidase M that is encoded in the genome of human.


name: CX7A2_HUMAN Cytochrome c oxidase subunit 7A2, mitochondrial (sprot)

description: A cytochrome c oxidase subunit 7A2, mitochondrial that is encoded in the genome of human.


name: SUIS_HUMAN Sucrase-isomaltase, intestinal (sprot)

description: A sucrase-isomaltase, intestinal that is encoded in the genome of human.


oligo-1,6-glucosidase activity

description: Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose.


sucrose alpha-glucosidase activity

description: Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose.


sucrose catabolic process

description: The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside.


name: AT1B2_HUMAN Sodium/potassium-transporting ATPase subunit beta-2 (sprot)

description: A sodium/potassium-transporting ATPase subunit beta-2 that is encoded in the genome of human.


lateral ventricle development

description: The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle.


third ventricle development

description: The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina.


name: neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration

description: The changes in adhesion between a neuronal cell and a glial cell as a component of the process of hindbrain glial-mediated radial cell migration.


name: plasma membrane bounded cell projection organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon.


name: negative regulation of glial cell migration

description: Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration.


cell projection membrane

description: The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.


cell body membrane

description: The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections.


name: DRD2_HUMAN D(2) dopamine receptor (sprot)

description: A D(2) dopamine receptor that is encoded in the genome of human.


name: dopamine neurotransmitter receptor activity, coupled via Gi/Go

description: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.


name: nervous system process involved in regulation of systemic arterial blood pressure

description: The regulation of blood pressure mediated by detection of stimuli and a neurological response.


orbitofrontal cortex development

description: The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe.


name: cerebral cortex GABAergic interneuron migration

description: The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex.


peristalsis

description: A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.


auditory behavior

description: The behavior of an organism in response to a sound.


name: negative regulation of dopamine secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine.


response to histamine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.


name: negative regulation of circadian sleep/wake cycle, sleep

description: Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.


regulation of potassium ion transport

description: Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


acid secretion

description: The controlled release of acid by a cell or a tissue.


behavioral response to cocaine

description: Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.


branching morphogenesis of a nerve

description: The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).


name: positive regulation of dopamine uptake involved in synaptic transmission

description: Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell.


name: regulation of synapse structural plasticity

description: Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane.


name: negative regulation of synaptic transmission, glutamatergic

description: Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.


name: regulation of locomotion involved in locomotory behavior

description: Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.


name: positive regulation of glial cell-derived neurotrophic factor production

description: Any process that activates or increases the frequency, rate or extent of glial cell-derived neurotrophic factor production.


G protein-coupled receptor complex

description: A protein complex that contains G protein-coupled receptors.


NID1_HUMAN Nidogen-1 (sprot)

A nidogen-1 that is encoded in the genome of human.


name: AK1A1_HUMAN Aldo-keto reductase family 1 member A1 (sprot)

description: An aldo-keto reductase family 1 member A1 that is encoded in the genome of human.


L-glucuronate reductase activity

description: Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + H+ + NADPH.


glucuronolactone reductase activity

description: Catalysis of the reaction: L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + H+ + NADPH.


glycerol dehydrogenase (NADP+) activity

description: Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH.


name: S-nitrosoglutathione reductase (NADH) activity

description: Catalysis of the reaction: S-nitrosoglutathione + NADH + H+ = S-(hydroxysulfenamide)glutathione + NAD+.


name: S-nitrosoglutathione reductase (NADPH) activity

description: Catalysis of the reaction: H+ + NADPH + S-nitrosoglutathione = NADP+ + S-(hydroxysulfenamide)glutathione.


name: methylglyoxal reductase (NADPH) (acetol producing) activity

description: Catalysis of the reaction: hydroxyacetone + NADP+ = H+ + methylglyoxal + NADPH.


L-ascorbic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.


D-glucuronate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate.


name: PA2GA_HUMAN Phospholipase A2, membrane associated (sprot)

description: A phospholipase A2, membrane associated that is encoded in the genome of human.


regulation of neutrophil activation

description: Any process that modulates the frequency, rate or extent of neutrophil activation.


name: NCF1_HUMAN Neutrophil cytosol factor 1 (sprot)

description: A neutrophil cytosol factor 1 that is encoded in the genome of human.


name: positive regulation of epidermal growth factor-activated receptor activity

description: Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity.


name: reactive oxygen species biosynthetic process

description: The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.


phagolysosome

description: A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes.


name: INSRR_HUMAN Insulin receptor-related protein (sprot)

description: An insulin receptor-related protein that is encoded in the genome of human.


cellular response to alkaline pH

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution.


KPYM_HUMAN Pyruvate kinase PKM (sprot)

A pyruvate kinase PKM that is encoded in the genome of human.


pyruvate kinase activity

description: Catalysis of the reaction: = ADP + H+ + phosphoenolpyruvate => ATP + pyruvate.


ACYP2_HUMAN Acylphosphatase-2 (sprot)

An acylphosphatase-2 that is encoded in the genome of human.


ENPL_HUMAN Endoplasmin (sprot)

An endoplasmin that is encoded in the genome of human.


actin rod assembly

description: The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules.


name: regulation of phosphoprotein phosphatase activity

description: Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.


name: CCNB1_HUMAN G2/mitotic-specific cyclin-B1 (sprot)

description: A G2/mitotic-specific cyclin-B1 that is encoded in the genome of human.


name: positive regulation of attachment of spindle microtubules to kinetochore

description: Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore.


name: regulation of mitotic cell cycle spindle assembly checkpoint

description: Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.


name: MYL6B_HUMAN Myosin light chain 6B (sprot)

description: A myosin light chain 6B that is encoded in the genome of human.


name: HXB3_HUMAN Homeobox protein Hox-B3 (sprot)

description: A homeobox protein Hox-B3 that is encoded in the genome of human.


rhombomere development

description: The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.


name: HXB2_HUMAN Homeobox protein Hox-B2 (sprot)

description: A homeobox protein Hox-B2 that is encoded in the genome of human.


rhombomere 3 development

description: The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


rhombomere 4 development

description: The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


neural nucleus development

description: The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma.


name: HXB1_HUMAN Homeobox protein Hox-B1 (sprot)

description: A homeobox protein Hox-B1 that is encoded in the genome of human.


rhombomere 5 development

description: The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


facial nucleus development

description: The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure.


name: anatomical structure formation involved in morphogenesis

description: The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.


name: GLUT4_HUMAN Solute carrier family 2, facilitated glucose transporter member 4 (sprot)

description: A solute carrier family 2, facilitated glucose transporter member 4 that is encoded in the genome of human.


name: positive regulation of brain-derived neurotrophic factor receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway.


glucose uniporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in).


amylopectin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of amylopectin, the (1->4) linked alpha glucose units with alpha-(1->6) linkages.


name: glucose import in response to insulin stimulus

description: The directed movement of the hexose monosaccharide glucose into a cell as a result of an insulin stimulus.


name: regulation of synaptic vesicle budding from presynaptic endocytic zone membrane

description: Any process that modulates the frequency, rate or extent of synaptic vesicle budding from presynaptic endocytic zone membrane.


insulin-responsive compartment

description: A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2.


name: RSMB_HUMAN Small nuclear ribonucleoprotein-associated proteins B and B' (sprot)

description: A small nuclear ribonucleoprotein-associated proteins B and B' that is encoded in the genome of human.


histone pre-mRNA DCP binding

description: Binding to the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing.


U2 snRNP binding

description: Binding to a U2 small nuclear ribonucleoprotein particle.


7-methylguanosine cap hypermethylation

description: Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation.


U4 snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes.


U7 snRNP

description: A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs.


TYRO_HUMAN Tyrosinase (sprot)

A tyrosinase that is encoded in the genome of human.


tyrosinase activity

description: Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates.


name: melanin biosynthetic process from tyrosine

description: The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.


eye pigment biosynthetic process

description: The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye.


response to blue light

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm.


name: IDE_HUMAN Insulin-degrading enzyme (sprot)

description: An insulin-degrading enzyme that is encoded in the genome of human.


ubiquitin recycling

description: Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell by recycling ubiquitin from proteasome-bound ubiquitinated intermediates.


name: GPIX_HUMAN Platelet glycoprotein IX (sprot)

description: A platelet glycoprotein IX that is encoded in the genome of human.


name: IL1R1_HUMAN Interleukin-1 receptor type 1 (sprot)

description: An interleukin-1 receptor type 1 that is encoded in the genome of human.


interleukin-1 receptor activity

description: Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.


name: interleukin-1, type I, activating receptor activity

description: Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins.


name: positive regulation of neutrophil extravasation

description: Any process that activates or increases the frequency, rate or extent of neutrophil extravasation.


name: positive regulation of interleukin-1-mediated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of interleukin-1-mediated signaling pathway.


name: MMP9_HUMAN Matrix metalloproteinase-9 (sprot)

description: A matrix metalloproteinase-9 that is encoded in the genome of human.


positive regulation of receptor binding

description: Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor.


name: negative regulation of epithelial cell differentiation involved in kidney development

description: Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation involved in kidney development.


name: negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway.


name: IL2RB_HUMAN Interleukin-2 receptor subunit beta (sprot)

description: An interleukin-2 receptor subunit beta that is encoded in the genome of human.


interleukin-2 binding

description: Binding to interleukin-2.


interleukin-15 receptor activity

description: Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: CX6B1_HUMAN Cytochrome c oxidase subunit 6B1 (sprot)

description: A cytochrome c oxidase subunit 6B1 that is encoded in the genome of human.


name: PO2F1_HUMAN POU domain, class 2, transcription factor 1 (sprot)

description: A POU domain, class 2, transcription factor 1 that is encoded in the genome of human.


name: HNRPL_HUMAN Heterogeneous nuclear ribonucleoprotein L (sprot)

description: A heterogeneous nuclear ribonucleoprotein L that is encoded in the genome of human.


pre-mRNA intronic binding

description: Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA).


name: GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-1 that is encoded in the genome of human.


GABA receptor activity

description: Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms.


name: SYDC_HUMAN Aspartate--tRNA ligase, cytoplasmic (sprot)

description: An aspartate--tRNA ligase, cytoplasmic that is encoded in the genome of human.


name: I23O1_HUMAN Indoleamine 2,3-dioxygenase 1 (sprot)

description: An indoleamine 2,3-dioxygenase 1 that is encoded in the genome of human.


name: regulation of activated T cell proliferation

description: Any process that modulates the frequency, rate or extent of activated T cell proliferation.


indoleamine 2,3-dioxygenase activity

description: Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine.


name: positive regulation of T cell tolerance induction

description: Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.


name: positive regulation of chronic inflammatory response

description: Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response.


name: tryptophan catabolic process to kynurenine

description: The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.


swimming behavior

description: The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.


smooth muscle contractile fiber

description: The contractile fiber of smooth muscle cells.


OXDA_HUMAN D-amino-acid oxidase (sprot)

A D-amino-acid oxidase that is encoded in the genome of human.


D-amino-acid oxidase activity

description: Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.


D-amino acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids.


D-serine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.


D-alanine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of D-alanine, the D-enantiomer of the amino acid alanine.


D-serine metabolic process

description: The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid.


ETS1_HUMAN Protein C-ets-1 (sprot)

A protein C-ets-1 that is encoded in the genome of human.


PLAK_HUMAN Junction plakoglobin (sprot)

A junction plakoglobin that is encoded in the genome of human.


hemidesmosome

description: A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces.


name: cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication

description: Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells.


name: cytoskeletal protein-membrane anchor activity

description: The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a plasma membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific cortical membrane location.


desmosome assembly

description: A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.


endothelial cell-cell adhesion

description: The attachment of an endothelial cell to another endothelial cell via adhesion molecules.


name: bundle of His cell-Purkinje myocyte adhesion involved in cell communication

description: The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate.


name: regulation of ventricular cardiac muscle cell action potential

description: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


gamma-catenin-TCF7L2 complex

description: A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.


name: QCR7_HUMAN Cytochrome b-c1 complex subunit 7 (sprot)

description: A cytochrome b-c1 complex subunit 7 that is encoded in the genome of human.


name: LIF_HUMAN Leukemia inhibitory factor (sprot)

description: A leukemia inhibitory factor that is encoded in the genome of human.


name: leukemia inhibitory factor receptor binding

description: Binding to an leukemia inhibitory factor receptor.


name: negative regulation of meiotic nuclear division

description: Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.


name: leukemia inhibitory factor signaling pathway

description: The series of molecular signals initiated by the binding of a leukemia inhibitory factor to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

description: Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.


name: regulation of metanephric nephron tubule epithelial cell differentiation

description: Any process that modulates the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation.


meiotic nuclear division

description: One of the two nuclear divisions that occur as part of the meiotic cell cycle.


ETS2_HUMAN Protein C-ets-2 (sprot)

A protein C-ets-2 that is encoded in the genome of human.


ectodermal cell fate commitment

description: The cell differentiation process that results in commitment of a cell to become part of the ectoderm.


name: BRAF_HUMAN Serine/threonine-protein kinase B-raf (sprot)

description: A B-Raf proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human.


name: CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

description: The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells.


name: negative regulation of synaptic vesicle exocytosis

description: Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis.


CBPA1_HUMAN Carboxypeptidase A1 (sprot)

A carboxypeptidase A1 that is encoded in the genome of human.


CBPB1_HUMAN Carboxypeptidase B (sprot)

A carboxypeptidase B that is encoded in the genome of human.


name: CBPA3_HUMAN Mast cell carboxypeptidase A (sprot)

description: A mast cell carboxypeptidase A that is encoded in the genome of human.


name: FABP4_HUMAN Fatty acid-binding protein, adipocyte (sprot)

description: A fatty acid-binding protein, adipocyte that is encoded in the genome of human.


GLNA_HUMAN Glutamine synthetase (sprot)

A glutamine synthetase that is encoded in the genome of human.


glutamine synthetase activity

description: Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate.


glutamine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid.


protein palmitoylation

description: The covalent attachment of a palmitoyl group to a protein.


name: ALDR_HUMAN Aldo-keto reductase family 1 member B1 (sprot)

description: An aldo-keto reductase family 1 member B1 that is encoded in the genome of human.


name: prostaglandin H2 endoperoxidase reductase activity

description: Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate).


glyceraldehyde oxidoreductase activity

description: Catalysis of the reaction: A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H+.


fructose biosynthetic process

description: The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose.


AMPN_HUMAN Aminopeptidase N (sprot)

An aminopeptidase N that is encoded in the genome of human.


PVR_HUMAN Poliovirus receptor (sprot)

A poliovirus receptor that is encoded in the genome of human.


name: susceptibility to natural killer cell mediated cytotoxicity

description: The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity.


name: susceptibility to T cell mediated cytotoxicity

description: The process of causing a cell to become susceptible to T cell mediated cytotoxicity.


name: RAC2_HUMAN Ras-related C3 botulinum toxin substrate 2 (sprot)

description: A Ras-related C3 botulinum toxin substrate 2 that is encoded in the genome of human.


name: regulation of hydrogen peroxide metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide.


regulation of cell-substrate adhesion

description: Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.


regulation of T cell proliferation

description: Any process that modulates the frequency, rate or extent of T cell proliferation.


regulation of respiratory burst

description: Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.


regulation of mast cell chemotaxis

description: Any process that modulates the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus.


regulation of neutrophil migration

description: Any process that modulates the frequency, rate or extent of neutrophil migration.


name: CBPN_HUMAN Carboxypeptidase N catalytic chain (sprot)

description: A carboxypeptidase N catalytic chain that is encoded in the genome of human.


name: ERF3A_HUMAN Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (sprot)

description: A eukaryotic peptide chain release factor GTP-binding subunit ERF3A that is encoded in the genome of human.


regulation of translational termination

description: Any process that modulates the frequency, rate or extent of translational termination.


translation release factor complex

description: A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome.


name: MYOD1_HUMAN Myoblast determination protein 1 (sprot)

description: A myoblast determination protein 1 that is encoded in the genome of human.


name: positive regulation of skeletal muscle tissue regeneration

description: Any process that activates or increase the rate of skeletal muscle regeneration.


skeletal muscle fiber adaptation

description: Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.


name: positive regulation of snRNA transcription by RNA polymerase II

description: Any process that activates or increases the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II.


MYOG_HUMAN Myogenin (sprot)

A myogenin that is encoded in the genome of human.


name: positive regulation of myotube differentiation

description: Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


name: response to electrical stimulus involved in regulation of muscle adaptation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation.


name: response to denervation involved in regulation of muscle adaptation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation.


regulation of myoblast fusion

description: Any process that modulates the frequency, rate or extent of myoblast fusion.


IL9_HUMAN Interleukin-9 (sprot)

An interleukin-9 that is encoded in the genome of human.


name: PGAM2_HUMAN Phosphoglycerate mutase 2 (sprot)

description: A phosphoglycerate mutase 2 that is encoded in the genome of human.


phosphoglycerate mutase activity

description: Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.


name: INGR1_HUMAN Interferon gamma receptor 1 (sprot)

description: An interferon gamma receptor alpha chain that is encoded in the genome of human.


type II interferon receptor activity

description: Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


ARSA_HUMAN Arylsulfatase A (sprot)

An arylsulfatase A that is encoded in the genome of human.


cerebroside-sulfatase activity

description: Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate.


name: B4GT1_HUMAN Beta-1,4-galactosyltransferase 1 (sprot)

description: A beta-1,4-galactosyltransferase 1 that is encoded in the genome of human.


name: development of secondary sexual characteristics

description: The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion.


name: positive regulation of circulating fibrinogen levels

description: Any process that increases the quantity of fibrinogen circulating in the bloodstream.


Golgi trans cisterna

description: The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.


name: PPAP_HUMAN Prostatic acid phosphatase (sprot)

description: A prostatic acid phosphatase that is encoded in the genome of human.


acid phosphatase activity

description: Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.


5'-nucleotidase activity

description: Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.


thiamine phosphate phosphatase activity

description: Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate.


XMP 5'-nucleosidase activity

description: Catalysis of the reaction: 5'XMP + H20 = phosphate + xanthosine.


thiamine metabolic process

description: The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.


name: positive regulation of adenosine receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands.


EZRI_HUMAN Ezrin (sprot)

An ezrin that is encoded in the genome of human.


cortical microtubule organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.


protein localization to cell cortex

description: A process in which a protein is transported to, or maintained in, the cell cortex.


regulation of organelle assembly

description: Any process that modulates the frequency, rate or extent of organelle assembly.


negative regulation of p38MAPK cascade

description: Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade.


name: positive regulation of early endosome to late endosome transport

description: Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport.


name: VATB1_HUMAN V-type proton ATPase subunit B, kidney isoform (sprot)

description: A V-type proton ATPase subunit B, kidney isoform that is encoded in the genome of human.


renal sodium excretion

description: The elimination of sodium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine.


pH reduction

description: Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.


renal tubular secretion

description: The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.


name: FOLR1_HUMAN Folate receptor alpha (sprot)

description: A folate receptor alpha that is encoded in the genome of human.


name: neural crest cell migration involved in heart formation

description: The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation.


anterior neural tube closure

description: The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline.


name: ATF2_HUMAN Cyclic AMP-dependent transcription factor ATF-2 (sprot)

description: A cyclic AMP-dependent transcription factor ATF-2 that is encoded in the genome of human.


histone H2B acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine.


brainstem development

description: The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.


name: growth plate cartilage chondrocyte differentiation

description: The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage.


vacuole organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.


abducens nucleus development

description: The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure.


hypoglossal nucleus development

description: The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure.


detection of cell density

description: The series of events in which information about the density of cells in a population is received and converted into a molecular signal.


cellular response to leucine starvation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine.


H4 histone acetyltransferase complex

description: A protein complex which is capable of H4 histone acetyltransferase activity.


name: UCHL3_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L3 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase isozyme L3 that is encoded in the genome of human.


deNEDDylase activity

description: An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.


name: KCNE1_HUMAN Potassium voltage-gated channel subfamily E member 1 (sprot)

description: A potassium voltage-gated channel subfamily E member 1 that is encoded in the genome of human.


name: voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

description: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


vestibular nucleus development

description: The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure.


cellular response to acidic pH

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.


cellular response to light stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.


name: ventricular cardiac muscle cell action potential

description: An action potential that occurs in a ventricular cardiac muscle cell.


name: membrane repolarization during action potential

description: The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.


name: regulation of delayed rectifier potassium channel activity

description: Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity.


name: negative regulation of delayed rectifier potassium channel activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity.


name: CD19_HUMAN B-lymphocyte antigen CD19 (sprot)

description: A CD19 molecule that is encoded in the genome of human.


B-1 B cell differentiation

description: The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.


name: antigen receptor-mediated signaling pathway

description: The series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell.


regulation of B cell activation

description: Any process that modulates the frequency, rate or extent of B cell activation.


name: FOSL1_HUMAN Fos-related antigen 1 (sprot)

description: A Fos-related antigen 1 that is encoded in the genome of human.


vitellogenesis

description: The production of yolk. Yolk is a mixture of materials used for embryonic nutrition.


name: FOSL2_HUMAN Fos-related antigen 2 (sprot)

description: A Fos-related antigen 2 that is encoded in the genome of human.


cell death

description: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).


response to interleukin-13

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus.


chondrocyte proliferation

description: The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.


lung connective tissue development

description: The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs.


alveolar secondary septum development

description: The progression of a secondary alveolar septum over time, from its formation to the mature structure. A secondary alveolar septum is a specialized epithelium that subdivides the initial saccule.


response to interleukin-7

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus.


fat cell apoptotic process

description: Any apoptotic process in a fat cell.


name: regulation of myofibroblast differentiation

description: Any process that modulates the frequency, rate or extent of myofibroblast differentiation.


response to leukemia inhibitory factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.


name: PGDH_HUMAN 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (sprot)

description: A 15-hydroxyprostaglandin dehydrogenase [NAD(+)] that is encoded in the genome of human.


prostaglandin E receptor activity

description: Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.


name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.


ductus arteriosus closure

description: The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs.


name: regulation of prostaglandin catabolic process

description: Any process that modulates the frequency, rate or extent of prostaglandin catabolic process.


VAV_HUMAN Proto-oncogene vav (sprot)

A proto-oncogene vav that is encoded in the genome of human.


ELN_HUMAN Elastin (sprot)

An elastin that is encoded in the genome of human.


name: CSF2R_HUMAN Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (sprot)

description: A granulocyte-macrophage colony-stimulating factor receptor subunit alpha that is encoded in the genome of human.


AREG_HUMAN Amphiregulin (sprot)

An amphiregulin that is encoded in the genome of human.


name: dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis

description: The process in which the terminal end of a mammary duct bifurcates.


HIS1_HUMAN Histatin-1 (sprot)

A histatin-1 that is encoded in the genome of human.


name: positive regulation of metabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.


name: positive regulation of vascular wound healing

description: Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.


name: positive regulation of wound healing, spreading of epidermal cells

description: Any process that activates or increases the frequency, rate or extent of wound healing, spreading of epidermal cells.


HIS3_HUMAN Histatin-3 (sprot)

A histatin-3 that is encoded in the genome of human.


name: MCP_HUMAN Membrane cofactor protein (sprot)

description: A membrane cofactor protein that is encoded in the genome of human.


name: sequestering of extracellular ligand from receptor

description: The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor.


inner acrosomal membrane

description: The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane.


name: NDKA_HUMAN Nucleoside diphosphate kinase A (sprot)

description: A nucleoside diphosphate kinase A that is encoded in the genome of human.


3'-5' exonuclease activity

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.


name: C11B1_HUMAN Cytochrome P450 11B1, mitochondrial (sprot)

description: A cytochrome P450 11B that is a translation product of the CYP11B1 gene in human.


steroid 11-beta-monooxygenase activity

description: Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.


name: NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1 (sprot)

description: An NAD(P)H dehydrogenase [quinone] 1 that is encoded in the genome of human.


name: NADH:ubiquinone reductase (non-electrogenic) activity

description: Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.


ubiquinone metabolic process

description: The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme.


vitamin E metabolic process

description: The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.


vitamin K metabolic process

description: The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.


NADPH oxidation

description: A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP.


response to L-glutamine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus.


response to hydrogen sulfide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus.


response to flavonoid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus.


An N-acetylglucosamine-6-sulfatase that is encoded in the genome of human.


description: Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.


keratan sulfate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.


name: ZNF44_HUMAN Zinc finger protein 44 (sprot)

description: A zinc finger protein 44 that is encoded in the genome of human.


name: ZN250_HUMAN Zinc finger protein 250 (sprot)

description: A zinc finger protein 250 that is encoded in the genome of human.


name: VEGFA_HUMAN Vascular endothelial growth factor A, long form (sprot)

description: A vascular endothelial growth factor A, long form that is encoded in the genome of human.


name: vascular endothelial growth factor receptor 1 binding

description: Binding to a vascular endothelial growth factor receptor 1.


lymphangiogenesis

description: Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.


coronary vein morphogenesis

description: The process in which the anatomical structures of veins of the heart are generated and organized.


lymph vessel morphogenesis

description: The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph.


name: positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

description: The series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis.


primitive erythrocyte differentiation

description: Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis.


name: cardiac vascular smooth muscle cell development

description: The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state.


vascular wound healing

description: Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.


name: cellular stress response to acid chemical

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.


name: positive regulation of lymphangiogenesis

description: Any process that activates or increases the frequency, rate or extent of lymphangiogenesis.


name: negative regulation of establishment of endothelial barrier

description: Any process that stops, prevents or reduces the frequency, rate or extent of establishment of endothelial barrier.


name: negative regulation of adherens junction organization

description: Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization.


name: negative regulation of blood-brain barrier permeability

description: Any process that decreases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain.


VEGF-A complex

description: A homodimeric, extracellular protein complex containing two VEGF-A monomers. Binds to and activates a receptor tyrosine kinase.


name: PHKG2_HUMAN Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (sprot)

description: A phosphorylase b kinase gamma catalytic chain, liver/testis isoform that is encoded in the genome of human.


phosphorylase kinase activity

description: Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a.


name: positive regulation of glycogen catabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.


phosphorylase kinase complex

description: An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a.


name: CD1E_HUMAN T-cell surface glycoprotein CD1e, membrane-associated (sprot)

description: A T-cell surface glycoprotein CD1e that is encoded in the genome of human.


name: CD1D_HUMAN Antigen-presenting glycoprotein CD1d (sprot)

description: An antigen-presenting glycoprotein CD1d that is encoded in the genome of human.


lipid antigen binding

description: Binding to a lipid antigen.


exogenous lipid antigen binding

description: Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids).


name: antigen processing and presentation, endogenous lipid antigen via MHC class Ib

description: The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.


name: IGLL1_HUMAN Immunoglobulin lambda-like polypeptide 1 (sprot)

description: An immunoglobulin lambda-like polypeptide 1 that is encoded in the genome of human.


name: ZEP1_HUMAN Zinc finger protein 40 (sprot)

description: A zinc finger protein 40 that is encoded in the genome of human.


ARSB_HUMAN Arylsulfatase B (sprot)

An arylsulfatase B that is encoded in the genome of human.


description: Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.


arylsulfatase activity

description: Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate.


colon epithelial cell migration

description: The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism.


name: PAX1_HUMAN Paired box protein Pax-1 (sprot)

description: A paired box protein Pax-1 that is encoded in the genome of human.


name: RS2_HUMAN Small ribosomal subunit protein uS5 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS5 that is encoded in the genome of human.


name: positive regulation of ubiquitin-protein transferase activity

description: Any process that activates, maintains or increases the rate of ubiquitin transferase activity.


CHIN_HUMAN N-chimaerin (sprot)

An N-chimaerin that is encoded in the genome of human.


name: ITF2_HUMAN Transcription factor 4 (sprot)

description: A transcription factor 4 that is encoded in the genome of human.


beta-catenin-TCF7L2 complex

description: A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.


name: SIAT1_HUMAN Beta-galactoside alpha-2,6-sialyltransferase 1 (sprot)

description: A beta-galactoside alpha-2,6-sialyltransferase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactoside = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H+.


N-acetylneuraminate metabolic process

description: The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid.


name: regulation of substrate adhesion-dependent cell spreading

description: Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading.


name: RAG1_HUMAN V(D)J recombination-activating protein 1 (sprot)

description: A V(D)J recombination-activating protein 1 that is encoded in the genome of human.


pre-B cell allelic exclusion

description: Expression of a single heavy chain allele during pre-B cell differentiation.


name: TFE2_HUMAN Transcription factor E2-alpha (sprot)

description: A transcription factor E2-alpha that is encoded in the genome of human.


immunoglobulin V(D)J recombination

description: The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined.


DESP_HUMAN Desmoplakin (sprot)

A desmoplakin that is encoded in the genome of human.


desmosome organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.


name: ventricular compact myocardium morphogenesis

description: The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized.


name: protein localization to cell-cell junction

description: A process in which a protein is transported to, or maintained, in a location within a cell-cell junction.


name: RFA2_HUMAN Replication protein A 32 kDa subunit (sprot)

description: A replication protein A 32 kDa subunit that is encoded in the genome of human.


protein localization to chromosome

description: Any process in which a protein is transported to, or maintained at, a specific location on a chromosome.


regulation of DNA damage checkpoint

description: Any process that modulates the frequency, rate or extent of a DNA damage checkpoint.


MUC1_HUMAN Mucin-1 (sprot)

A mucin-1 that is encoded in the genome of human.


name: COX7C_HUMAN Cytochrome c oxidase subunit 7C, mitochondrial (sprot)

description: A cytochrome c oxidase subunit 7C, mitochondrial that is encoded in the genome of human.


name: GATA1_HUMAN Erythroid transcription factor (sprot)

description: An erythroid transcription factor that is encoded in the genome of human.


C2H2 zinc finger domain binding

description: Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.


name: regulation of definitive erythrocyte differentiation

description: Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis.


name: regulation of primitive erythrocyte differentiation

description: Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis.


basophil differentiation

description: The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell.


eosinophil fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a eosinophil cell. A eosinophil is any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin.


name: TIMP2_HUMAN Metalloproteinase inhibitor 2 (sprot)

description: A metalloproteinase inhibitor 2 that is encoded in the genome of human.


name: LOX15_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX15 (sprot)

description: A polyunsaturated fatty acid lipoxygenase ALOX15 that is encoded in the genome of human.


description: The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.


name: regulation of peroxisome proliferator activated receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.


cellular response to interleukin-13

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus.


name: regulation of engulfment of apoptotic cell

description: Any process that modulates the frequency, rate or extent of engulfment of apoptotic cell.


name: ANPRA_HUMAN Atrial natriuretic peptide receptor 1 (sprot)

description: An atrial natriuretic peptide receptor 1 that is encoded in the genome of human.


guanylate cyclase activity

description: Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.


natriuretic peptide receptor activity

description: Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.


name: positive regulation of cGMP-mediated signaling

description: Any process that increases the rate, frequency or extent of cGMP-mediated signaling.


ANPR-A receptor complex

description: A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure.


CD44_HUMAN CD44 antigen (sprot)

A CD44 molecule that is encoded in the genome of human.


name: positive regulation of monocyte aggregation

description: Any process that activates or increases the frequency, rate or extent of monocyte aggregation.


name: NQO2_HUMAN Ribosyldihydronicotinamide dehydrogenase [quinone] (sprot)

description: A ribosyldihydronicotinamide dehydrogenase [quinone] that is encoded in the genome of human.


name: dihydronicotinamide riboside quinone reductase activity

description: Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone.


name: oxidoreductase activity, acting on other nitrogenous compounds as donors

description: Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


melatonin binding

description: Binding to melatonin.


resveratrol binding

description: Binding to resveratrol.


quinone catabolic process

description: The chemical reactions and pathways resulting in the breakdown of quinone.


H2AX_HUMAN Histone H2AX (sprot)

A histone H2AX that is encoded in the genome of human.