paranodal junction maintenance

description: The maintenance of a paranodal junction, a highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. A paranodal junction flanks the node of Ranvier in myelinated nerve, electrically isolates the myelinated from unmyelinated nerve segments, and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.


name: CTG1B_HUMAN Cancer/testis antigen 1 (sprot)

description: A cancer/testis antigen 1 that is encoded in the genome of human.


name: SRPK2_HUMAN SRSF protein kinase 2 (sprot)

description: An SRSF protein kinase 2 that is encoded in the genome of human.


name: ABCA4_HUMAN Retinal-specific phospholipid-transporting ATPase ABCA4 (sprot)

description: A retinal-specific phospholipid-transporting ATPase ABCA4 that is encoded in the genome of human.


flippase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.


description: Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.


phospholipid transfer to membrane

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The transfer of a phospholipid from its site of synthesis to the plasma membrane.


rod photoreceptor disc membrane

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Stack of disc membranes located inside a rod photoreceptor outer segment, and containing densely packed molecules of rhodopsin photoreceptor proteins that traverse the lipid bilayer. It is thought that rod disc membranes arise as evaginations of the ciliary membrane near the base of the outer segment, which then become completely separated from the ciliary membrane, during the development of the rod outer segment.


name: PHC1_HUMAN Polyhomeotic-like protein 1 (sprot)

description: A polyhomeotic-like protein 1 that is encoded in the genome of human.


name: NKX32_HUMAN Homeobox protein Nkx-3.2 (sprot)

description: A homeobox protein Nkx-3.2 that is encoded in the genome of human.


name: KC1G2_HUMAN Casein kinase I isoform gamma-2 (sprot)

description: A casein kinase I isoform gamma-2 that is encoded in the genome of human.


CLD10_HUMAN Claudin-10 (sprot)

A claudin-10 that is encoded in the genome of human.


name: TCPB_HUMAN T-complex protein 1 subunit beta (sprot)

description: A T-complex protein 1 subunit beta that is encoded in the genome of human.


name: chaperone mediated protein folding independent of cofactor

description: The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release.


name: OLR1_HUMAN Oxidized low-density lipoprotein receptor 1 (sprot)

description: An oxidized low-density lipoprotein receptor 1 that is encoded in the genome of human.


name: S35A2_HUMAN UDP-galactose translocator (sprot)

description: A UDP-galactose translocator that is encoded in the genome of human.


name: UDP-galactose transmembrane transporter activity

description: Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate.


UDP-galactose transmembrane transport

description: The process in which UDP-galactose is transported across a membrane.


name: S35A1_HUMAN CMP-sialic acid transporter (sprot)

description: A CMP-sialic acid transporter that is encoded in the genome of human.


name: CMP-N-acetylneuraminate transmembrane transporter activity

description: Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other.


description: The directed movement of CMP-N-acetylneuraminate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: S35B1_HUMAN Solute carrier family 35 member B1 (sprot)

description: A solute carrier family 35 member B1 that is encoded in the genome of human.


UDP-glucose transmembrane transport

description: The process in which UDP-glucose is transported across a membrane.


name: KRT83_HUMAN Keratin, type II cuticular Hb3 (sprot)

description: A keratin, type II cuticular Hb3 that is encoded in the genome of human.


name: KRT85_HUMAN Keratin, type II cuticular Hb5 (sprot)

description: A keratin, type II cuticular Hb5 that is encoded in the genome of human.


name: PRAME_HUMAN Melanoma antigen preferentially expressed in tumors (sprot)

description: A melanoma antigen preferentially expressed in tumors that is encoded in the genome of human.


CCNA1_HUMAN Cyclin-A1 (sprot)

A cyclin-A1 that is encoded in the genome of human.


name: RAE1L_HUMAN mRNA export factor RAE1 (sprot)

description: An mRNA export factor RAE1 that is encoded in the genome of human.


name: BT3A2_HUMAN Butyrophilin subfamily 3 member A2 (sprot)

description: A butyrophilin subfamily 3 member A2 that is encoded in the genome of human.


name: IRX5_HUMAN Iroquois-class homeodomain protein IRX-5 (sprot)

description: An iroquois-class homeodomain protein IRX-5 that is encoded in the genome of human.


name: IRX6_HUMAN Iroquois-class homeodomain protein IRX-6 (sprot)

description: An iroquois-class homeodomain protein IRX-6 that is encoded in the genome of human.


name: IRX4_HUMAN Iroquois-class homeodomain protein IRX-4 (sprot)

description: An iroquois-class homeodomain protein IRX-4 that is encoded in the genome of human.


name: establishment of animal organ orientation

description: The process that determines the orientation of an animal organ or tissue with reference to an axis.


name: IRX1_HUMAN Iroquois-class homeodomain protein IRX-1 (sprot)

description: An iroquois-class homeodomain protein IRX-1 that is encoded in the genome of human.


specification of loop of Henle identity

description: The process in which the loop of Henle of the kidney nephron acquires its identity.


name: proximal/distal pattern formation involved in metanephric nephron development

description: The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the metanephros. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end).


name: IRX3_HUMAN Iroquois-class homeodomain protein IRX-3 (sprot)

description: An iroquois-class homeodomain protein IRX-3 that is encoded in the genome of human.


Purkinje myocyte development

description: The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.


name: His-Purkinje system cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles.


name: GSTO1_HUMAN Glutathione S-transferase omega-1 (sprot)

description: A glutathione S-transferase omega-1 that is encoded in the genome of human.


name: glutathione dehydrogenase (ascorbate) activity

description: Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.


methylarsonate reductase activity

description: Catalysis of the reaction: 2 glutathione + H+ + methylarsonate = glutathione disulfide + H2O + methylarsonous acid.


name: positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.


X3CL1_HUMAN Fractalkine (sprot)

A fractalkine that is encoded in the genome of human.


CXCR1 chemokine receptor binding

description: Binding to a CXCR1 chemokine receptor.


leukocyte adhesive activation

description: The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation.


name: positive regulation of calcium-independent cell-cell adhesion

description: Any process that activates or increases the frequency, rate or extent of calcium-independent cell-cell adhesion.


name: negative regulation of glutamate receptor signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of glutamate receptor signaling pathway.


name: PO6F2_HUMAN POU domain, class 6, transcription factor 2 (sprot)

description: A POU domain, class 6, transcription factor 2 that is encoded in the genome of human.


name: NKX61_HUMAN Homeobox protein Nkx-6.1 (sprot)

description: A homeobox protein Nkx-6.1 that is encoded in the genome of human.


pancreatic A cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.


JAG1_HUMAN Protein jagged-1 (sprot)

A protein jagged-1 that is encoded in the genome of human.


ciliary body morphogenesis

description: The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes.


endocardial cushion cell development

description: The process whose specific outcome is the progression of an endocardial cushion cell over time, from its formation to the mature state.


regulation of reproductive process

description: Any process that modulates the frequency, rate or extent of reproductive process.


name: KCJ10_HUMAN ATP-sensitive inward rectifier potassium channel 10 (sprot)

description: An ATP-sensitive inward rectifier potassium channel 10 that is encoded in the genome of human.


glutamate reuptake

description: The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.


RELN_HUMAN Reelin (sprot)

A reelin that is encoded in the genome of human.


lipoprotein particle receptor binding

description: Binding to a lipoprotein particle receptor.


spinal cord patterning

description: The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord.


regulation of synaptic activity

description: Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell.


name: positive regulation of lateral motor column neuron migration

description: Any process that activates or increases the frequency, rate or extent of lateral motor column neuron migration.


reelin complex

description: An extracellular complex that binds lipoprotein receptors VLDLR and APOER2, cadherin-related neuronal receptors (CNRs) or alpha3beta1 integrin and induces various downstream, reelin-dependent, phosphorylation cascades. It ultimately affects polarization, differentiation, neuronal migration and layer formation in the embryonic brain and neuron growth, maturation, and synaptic activity in the postnatal and adult brain.


name: DEN2B_HUMAN DENN domain-containing protein 2B (sprot)

description: A DENN domain-containing protein 2B that is encoded in the genome of human.


name: PRKDC_HUMAN DNA-dependent protein kinase catalytic subunit (sprot)

description: A DNA-dependent protein kinase catalytic subunit that is encoded in the genome of human.


DNA-dependent protein kinase activity

description: DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


histone H2AXS139 kinase activity

description: Catalysis of the reaction: histone H2AX-serine (position 139) + ATP = histone H2AX-phosphoserine (position 139) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 139 of histone variant H2AX.


name: ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (sprot)

description: An ADAM 17 endopeptidase that is encoded in the genome of human.


name: regulation of mast cell apoptotic process

description: Any process that modulates the frequency, rate, or extent of mast cell apoptotic process.


name: BL1S1_HUMAN Biogenesis of lysosome-related organelles complex 1 subunit 1 (sprot)

description: A biogenesis of lysosome-related organelles complex 1 subunit 1 that is encoded in the genome of human.


peptidyl-lysine acetylation

description: The acetylation of peptidyl-lysine.


name: SRPX_HUMAN Sushi repeat-containing protein SRPX (sprot)

description: A sushi repeat-containing protein SRPX that is encoded in the genome of human.


name: negative regulation of cell proliferation involved in contact inhibition

description: Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density.


name: ARGI2_HUMAN Arginase-2, mitochondrial (sprot)

description: An arginase-2, mitochondrial that is encoded in the genome of human.


arginase activity

description: Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.


name: negative regulation of chemokine (C-C motif) ligand 4 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4.


name: negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process.


BTG2_HUMAN Protein BTG2 (sprot)

A protein BTG2 that is encoded in the genome of human.


name: ELF3_HUMAN ETS-related transcription factor Elf-3 (sprot)

description: An ETS-related transcription factor Elf-3 that is encoded in the genome of human.


name: NTH_HUMAN Endonuclease III-like protein 1 (sprot)

description: An endonuclease III-like protein 1 that is encoded in the genome of human.


name: oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

description: Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.


name: I13R1_HUMAN Interleukin-13 receptor subunit alpha-1 (sprot)

description: An interleukin-13 receptor subunit alpha-1 that is encoded in the genome of human.


interleukin-13 receptor complex

description: A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain.


name: CCL20_HUMAN C-C motif chemokine 20 (sprot)

description: A C-C motif chemokine 20 that is encoded in the genome of human.


name: MAP1A_HUMAN Microtubule-associated protein 1A (sprot)

description: A microtubule-associated protein 1A that is encoded in the genome of human.


retrograde axonal protein transport

description: The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons.


name: negative regulation of protein localization to microtubule

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule.


name: CRADD_HUMAN Death domain-containing protein CRADD (sprot)

description: A death domain-containing protein CRADD that is encoded in the genome of human.


name: PHEX_HUMAN Phosphate-regulating neutral endopeptidase PHEX (sprot)

description: A phosphate-regulating neutral endopeptidase PHEX that is encoded in the genome of human.


organophosphate metabolic process

description: The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound.


name: RED1_HUMAN Double-stranded RNA-specific editase 1 (sprot)

description: A double-stranded RNA-specific editase 1 that is encoded in the genome of human.


facial nerve morphogenesis

description: The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.


hypoglossal nerve morphogenesis

description: The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.


name: DRB3_HUMAN HLA class II histocompatibility antigen, DR beta 3 chain (sprot)

description: An MHC class II histocompatibility antigen beta chain DRB3 that is encoded in the genome of human.


name: PRR3_HUMAN Proline-rich protein 3 (sprot)

description: A proline-rich protein 3 that is encoded in the genome of human.


name: CCL8_HUMAN C-C motif chemokine 8 (sprot)

description: A C-C motif chemokine 8 that is encoded in the genome of human.


name: CCL7_HUMAN C-C motif chemokine 7 (sprot)

description: A C-C motif chemokine 7 that is encoded in the genome of human.


name: PHLD_HUMAN Phosphatidylinositol-glycan-specific phospholipase D (sprot)

description: A phosphatidylinositol-glycan-specific phospholipase D that is encoded in the genome of human.


name: glycosylphosphatidylinositol phospholipase D activity

description: Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol.


GPI anchor release

description: The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane.


name: positive regulation of alkaline phosphatase activity

description: Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.


name: positive regulation of high-density lipoprotein particle clearance

description: Any process that increases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


cellular response to triglyceride

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus.


name: CXCL6_HUMAN C-X-C motif chemokine 6 (sprot)

description: A C-X-C motif chemokine 6 that is encoded in the genome of human.


name: regulation of neutrophil mediated killing of gram-negative bacterium

description: Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-negative bacterium, the directed killing of a gram-negative bacterium by a neutrophil.


name: NGAL_HUMAN Neutrophil gelatinase-associated lipocalin (sprot)

description: A neutrophil gelatinase-associated lipocalin that is encoded in the genome of human.


siderophore transport

description: The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 (sprot)

description: A mitogen-activated protein kinase kinase kinase 9 that is encoded in the genome of human.


JUN kinase kinase kinase activity

description: Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).


name: IN35_HUMAN Interferon-induced 35 kDa protein (sprot)

description: An interferon-induced 35 kDa protein that is encoded in the genome of human.


MT1H_HUMAN Metallothionein-1H (sprot)

A metallothionein-1H that is encoded in the genome of human.


MT1X_HUMAN Metallothionein-1X (sprot)

A metallothionein-1X that is encoded in the genome of human.


NUCB2_HUMAN Nucleobindin-2 (sprot)

A nucleobindin-2 that is encoded in the genome of human.


name: DHI2_HUMAN 11-beta-hydroxysteroid dehydrogenase type 2 (sprot)

description: An 11-beta-hydroxysteroid dehydrogenase type 2 that is encoded in the genome of human.


name: 11-beta-hydroxysteroid dehydrogenase (NAD+) activity

description: Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+.


cortisol metabolic process

description: The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.


name: DLK1_HUMAN Protein delta homolog 1 (sprot)

description: A protein delta homolog 1 that is encoded in the genome of human.


name: GABT_HUMAN 4-aminobutyrate aminotransferase, mitochondrial (sprot)

description: A 4-aminobutyrate aminotransferase, mitochondrial that is encoded in the genome of human.


4-aminobutyrate transaminase activity

description: Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.


description: Binding to succinate-semialdehyde dehydrogenase.


description: Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.


description: Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.


4-aminobutyrate transaminase complex

description: A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity.


S10AC_HUMAN Protein S100-A12 (sprot)

A protein S100-A12 that is encoded in the genome of human.


name: BASP1_HUMAN Brain acid soluble protein 1 (sprot)

description: A brain acid soluble protein 1 that is encoded in the genome of human.


name: LV321_HUMAN Immunoglobulin lambda variable 3-21 (sprot)

description: A protein that is a translation product of the IGLV3-21 gene in human.


name: SIM1_HUMAN Single-minded homolog 1 (sprot)

description: A single-minded homolog 1 that is encoded in the genome of human.


HEPC_HUMAN Hepcidin (sprot)

A hepcidin that is encoded in the genome of human.


name: negative regulation of intestinal absorption

description: Any process that stops, prevents or reduces the frequency, rate or extent of intestinal absorption.


name: GPSM2_HUMAN G-protein-signaling modulator 2 (sprot)

description: A G-protein-signaling modulator 2 that is encoded in the genome of human.


positive regulation of spindle assembly

description: Any process that activates or increases the frequency, rate or extent of spindle assembly.


lateral cell cortex

description: The region directly beneath the plasma membrane of the lateral portion of the cell.


cell cortex region

description: The complete extent of cell cortex that underlies some some region of the plasma membrane.


name: PRRP_HUMAN Prolactin-releasing peptide (sprot)

description: A prolactin-releasing peptide that is encoded in the genome of human.


EREP3_HUMAN Protein ENTREP3 (sprot)

A protein ENTREP3 that is encoded in the genome of human.


D103A_HUMAN Beta-defensin 103 (sprot)

A beta-defensin 103 that is encoded in the genome of human.


DCD_HUMAN Dermcidin (sprot)

A dermcidin that is encoded in the genome of human.


name: SSBP2_HUMAN Single-stranded DNA-binding protein 2 (sprot)

description: A single-stranded DNA-binding protein 2 that is encoded in the genome of human.


name: TMF1_HUMAN TATA element modulatory factor (sprot)

description: A TATA element modulatory factor that is encoded in the genome of human.


name: BAT1_HUMAN b(0,+)-type amino acid transporter 1 (sprot)

description: A b(0,+)-type amino acid transporter 1 that is encoded in the genome of human.


name: broad specificity neutral L-amino acid:basic L-amino acid antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: basic L-amino acid(in) + neutral L-amino acid(out) = basic L-amino acid(in) + neutral L-amino acid(out).


name: CRUM1_HUMAN Protein crumbs homolog 1 (sprot)

description: A protein crumbs homolog 1 that is encoded in the genome of human.


name: establishment of bipolar cell polarity involved in cell morphogenesis

description: The specification and formation of bipolar intracellular organization or cell growth patterns that contribute to cell morphogenesis. Bipolar organization is the organization that is a mirror image along an axis from a plane.


subapical complex

description: The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells.


name: RT22_HUMAN Small ribosomal subunit protein mS22 (sprot)

description: A small ribosomal subunit protein mS22 that is encoded in the genome of human.


name: RT25_HUMAN Small ribosomal subunit protein mS25 (sprot)

description: A small ribosomal subunit protein mS25 that is encoded in the genome of human.


name: RT10_HUMAN Small ribosomal subunit protein uS10m (sprot)

description: A small ribosomal subunit protein uS10m that is encoded in the genome of human.


name: RT35_HUMAN Small ribosomal subunit protein mS35 (sprot)

description: A small ribosomal subunit protein mS35 that is encoded in the genome of human.


name: RT05_HUMAN Small ribosomal subunit protein uS5m (sprot)

description: A small ribosomal subunit protein uS5m that is encoded in the genome of human.


name: KGD4_HUMAN Alpha-ketoglutarate dehydrogenase component 4 (sprot)

description: An alpha-ketoglutarate dehydrogenase component 4 that is encoded in the genome of human.


name: RT11_HUMAN Small ribosomal subunit protein uS11m (sprot)

description: A small ribosomal subunit protein uS11m that is encoded in the genome of human.


name: RT15_HUMAN Small ribosomal subunit protein uS15m (sprot)

description: A small ribosomal subunit protein uS15m that is encoded in the genome of human.


name: RT21_HUMAN Small ribosomal subunit protein bS21m (sprot)

description: A small ribosomal subunit protein bS21m that is encoded in the genome of human.


name: RT34_HUMAN Small ribosomal subunit protein mS34 (sprot)

description: A small ribosomal subunit protein mS34 that is encoded in the genome of human.


name: RT06_HUMAN Small ribosomal subunit protein bS6m (sprot)

description: A small ribosomal subunit protein bS6m that is encoded in the genome of human.


name: RT09_HUMAN Small ribosomal subunit protein uS9m (sprot)

description: A small ribosomal subunit protein uS9m that is encoded in the genome of human.


name: HMGN5_HUMAN High mobility group nucleosome-binding domain-containing protein 5 (sprot)

description: A nucleosome-binding protein 1 that is encoded in the genome of human.


name: SARNP_HUMAN SAP domain-containing ribonucleoprotein (sprot)

description: A nuclear protein Hcc-1 that is encoded in the genome of human.


name: RET5_HUMAN Retinol-binding protein 5 (sprot)

description: A retinol-binding protein 5 that is encoded in the genome of human.


name: ATL3_HUMAN ADAMTS-like protein 3 (sprot)

description: An ADAMTS-like protein 3 that is encoded in the genome of human.


name: HTRA4_HUMAN Serine protease HTRA4 (sprot)

description: A serine protease HTRA4 that is encoded in the genome of human.


name: HTRA3_HUMAN Serine protease HTRA3 (sprot)

description: A serine protease HTRA3 that is encoded in the genome of human.


name: LACTB_HUMAN Serine beta-lactamase-like protein LACTB, mitochondrial (sprot)

description: A serine beta-lactamase-like protein LACTB, mitochondrial that is encoded in the genome of human.


name: LSM11_HUMAN U7 snRNA-associated Sm-like protein LSm11 (sprot)

description: A U7 snRNA-associated Sm-like protein LSm11 that is encoded in the genome of human.


name: mRNA 3'-end processing by stem-loop binding and cleavage

description: Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine.


name: COG7_HUMAN Conserved oligomeric Golgi complex subunit 7 (sprot)

description: A conserved oligomeric Golgi complex subunit 7 that is encoded in the genome of human.


name: retrograde transport, vesicle recycling within Golgi

description: The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi.


name: RL24_HUMAN Large ribosomal subunit protein eL24 (sprot)

description: A large ribosomal subunit protein eL24 that is encoded in the genome of human.


name: OX26_HUMAN Orexigenic neuropeptide QRFP (sprot)

description: An orexigenic neuropeptide QRFP that is encoded in the genome of human.


name: orexigenic neuropeptide QRFP receptor binding

description: Binding to an orexigenic neuropeptide QRFP receptor.


name: TXN4A_HUMAN Thioredoxin-like protein 4A (sprot)

description: A thioredoxin-like protein 4A that is encoded in the genome of human.


name: RL36A_HUMAN Large ribosomal subunit protein eL42 (sprot)

description: A large ribosomal subunit protein eL42 that is encoded in the genome of human.


name: CBX1_HUMAN Chromobox protein homolog 1 (sprot)

description: A chromobox protein homolog 1 that is encoded in the genome of human.


name: SMAD3_HUMAN Mothers against decapentaplegic homolog 3 (sprot)

description: A smad3 that is encoded in the genome of human.


name: nuclear mineralocorticoid receptor binding

description: Binding to a nuclear mineralocorticoid receptor.


name: positive regulation of transforming growth factor beta3 production

description: Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3.


paraxial mesoderm morphogenesis

description: The process in which the anatomical structures of the paraxial mesoderm are generated and organized.


name: negative regulation of lung blood pressure

description: The process that decreases the force with which blood travels through the lungs.


heteromeric SMAD protein complex

description: A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric.


name: HPCA_HUMAN Neuron-specific calcium-binding protein hippocalcin (sprot)

description: A neuron-specific calcium-binding protein hippocalcin that is encoded in the genome of human.


response to ketamine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketamine stimulus.


response to Aroclor 1254

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus.


name: ARF1_HUMAN ADP-ribosylation factor 1 (sprot)

description: An ADP-ribosylation factor 1 that is encoded in the genome of human.


mitotic cleavage furrow ingression

description: Advancement of the mitotic cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during mitotic cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed.


name: ARF5_HUMAN ADP-ribosylation factor 5 (sprot)

description: An ADP-ribosylation factor 5 that is encoded in the genome of human.


name: ERH_HUMAN Enhancer of rudimentary homolog (sprot)

description: An enhancer of rudimentary that is encoded in the genome of human.


name: RHOG_HUMAN Rho-related GTP-binding protein RhoG (sprot)

description: A Rho-related GTP-binding protein RhoG that is encoded in the genome of human.


name: RL19_HUMAN Large ribosomal subunit protein eL19 (sprot)

description: A large ribosomal subunit protein eL19 that is encoded in the genome of human.


name: SERF2_HUMAN Small EDRK-rich factor 2 (sprot)

description: A small EDRK-rich factor 2 that is encoded in the genome of human.


name: SRSF3_HUMAN Serine/arginine-rich splicing factor 3 (sprot)

description: A serine/arginine-rich splicing factor 3 that is encoded in the genome of human.


name: protein-RNA sequence-specific adaptor activity

description: A protein adaptor activity characterized by the capacity to selectively recognize and interact with RNA molecules in a sequence-specific manner. Entities possessing this activity typically exhibit discerning binding preferences for specific nucleotide sequences within RNA molecules, enabling the identification and engagement of distinct RNA motifs or structural elements. This function is integral to various biological processes, including RNA processing, transport, and regulatory mechanisms, contributing to the specificity and precision of cellular RNA-related activities.


name: MXRA7_HUMAN Matrix-remodeling-associated protein 7 (sprot)

description: A matrix-remodeling-associated protein 7 that is encoded in the genome of human.


H33_HUMAN Histone H3.3 (sprot)

A histone H3.3 that is encoded in the genome of human.


pericentric heterochromatin formation

description: The compaction of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by methylation of histone H3K9, into heterochromatin, resulting in the repression of transcription at pericentric DNA.


name: negative regulation of chromosome condensation

description: Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation.


name: SKOR1_HUMAN SKI family transcriptional corepressor 1 (sprot)

description: A ladybird homeobox corepressor 1 that is encoded in the genome of human.


name: FOXK1_HUMAN Forkhead box protein K1 (sprot)

description: A forkhead box protein K1 that is encoded in the genome of human.


name: RHG08_HUMAN Rho GTPase-activating protein 8 (sprot)

description: A Rho GTPase-activating protein 8 that is encoded in the genome of human.


name: PRR5_HUMAN Proline-rich protein 5 (sprot)

description: A protor-1 that is encoded in the genome of human.


name: HTD2_HUMAN Hydroxyacyl-thioester dehydratase type 2, mitochondrial (sprot)

description: A hydroxyacyl-thioester dehydratase type 2, mitochondrial that is encoded in the genome of human.


name: ZBED6_HUMAN Zinc finger BED domain-containing protein 6 (sprot)

description: A zinc finger BED domain-containing protein 6 that is encoded in the genome of human.


name: PR20E_HUMAN Proline-rich protein 20E (sprot)

description: A proline-rich protein 20E that is encoded in the genome of human.


name: PR20C_HUMAN Proline-rich protein 20C (sprot)

description: A proline-rich protein 20C that is encoded in the genome of human.


name: PR20D_HUMAN Proline-rich protein 20D (sprot)

description: A proline-rich protein 20D that is encoded in the genome of human.


name: CCZ1B_HUMAN Vacuolar fusion protein CCZ1 homolog B (sprot)

description: A vacuolar fusion protein CCZ1 homolog B that is encoded in the genome of human.


Mon1-Ccz1 complex

description: A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p.


name: CCZ1_HUMAN Vacuolar fusion protein CCZ1 homolog (sprot)

description: A vacuolar fusion protein CCZ1 homolog that is encoded in the genome of human.


name: GAK10_HUMAN Endogenous retrovirus group K member 10 Gag polyprotein (sprot)


name: TSG6_HUMAN Tumor necrosis factor-inducible gene 6 protein (sprot)

description: A tumor necrosis factor-inducible gene 6 protein that is encoded in the genome of human.


ENTK_HUMAN Enteropeptidase (sprot)

An enteropeptidase that is encoded in the genome of human.


name: SHC2_HUMAN SHC-transforming protein 2 (sprot)

description: An SHC-transforming protein 2 that is encoded in the genome of human.


DAB2_HUMAN Disabled homolog 2 (sprot)

A disabled homolog 2 that is encoded in the genome of human.


leading edge cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet.


MUC5A_HUMAN Mucin-5AC (sprot)

A mucin-5AC that is encoded in the genome of human.


FBLN2_HUMAN Fibulin-2 (sprot)

A fibulin-2 that is encoded in the genome of human.


name: IDD_HUMAN Integral membrane protein DGCR2/IDD (sprot)

description: An integral membrane protein DGCR2/IDD that is encoded in the genome of human.


name: VLDLR_HUMAN Very low-density lipoprotein receptor (sprot)

description: A very low-density lipoprotein receptor that is encoded in the genome of human.


reelin receptor activity

description: Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: PGBM_HUMAN Basement membrane-specific heparan sulfate proteoglycan core protein (sprot)

description: A basement membrane-specific heparan sulfate proteoglycan core protein that is encoded in the genome of human.


PKD1_HUMAN Polycystin-1 (sprot)

A polycystin-1 that is encoded in the genome of human.


mesonephric tubule development

description: The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros.


metanephric distal tubule morphogenesis

description: The process in which the anatomical structures of a metanephric distal tubule are generated and organized. The metanephric distal tubule is a metanephric nephron tubule that begins at the macula densa and extends to the metanephric connecting tubule.


polycystin complex

description: A stable heterodimeric complex composed of polycystin-1 and polycystin-2.


cation channel complex

description: An ion channel complex through which cations pass.


name: LRP2_HUMAN Low-density lipoprotein receptor-related protein 2 (sprot)

description: A low-density lipoprotein receptor-related protein 2 that is encoded in the genome of human.


diol metabolic process

description: The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic.


neuron projection arborization

description: The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites.


name: ZXDA_HUMAN Zinc finger X-linked protein ZXDA (sprot)

description: A zinc finger X-linked protein ZXDA that is encoded in the genome of human.


name: ZXDB_HUMAN Zinc finger X-linked protein ZXDB (sprot)

description: A zinc finger X-linked protein ZXDB that is encoded in the genome of human.


name: XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (sprot)

description: A baculoviral IAP repeat-containing protein 4 that is encoded in the genome of human.


endopeptidase regulator activity

description: Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.


copper ion homeostasis

description: Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell.


name: regulation of apoptosis involved in tissue homeostasis

description: Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue.


name: regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

description: Any process that modulates the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway.


name: RHG04_HUMAN Rho GTPase-activating protein 4 (sprot)

description: A Rho GTPase-activating protein 4 that is encoded in the genome of human.


EFNB1_HUMAN Ephrin-B1 (sprot)

An ephrin-B1 that is encoded in the genome of human.


FAM3A_HUMAN Protein FAM3A (sprot)

A protein FAM3A that is encoded in the genome of human.


name: negative regulation of antifungal innate immune response

description: Any process that stops, prevents or reduces the frequency, rate or extent of an antifungal innate immune response.


name: FGD1_HUMAN FYVE, RhoGEF and PH domain-containing protein 1 (sprot)

description: A FYVE, RhoGEF and PH domain-containing protein 1 that is encoded in the genome of human.


name: RBM10_HUMAN RNA-binding protein 10 (sprot)

description: An RNA-binding protein 10 that is encoded in the genome of human.


name: vascular associated smooth muscle cell apoptotic process

description: Any apoptotic process in a vascular associated smooth muscle cell.


name: FOXO4_HUMAN Forkhead box protein O4 (sprot)

description: A forkhead box protein O4 that is encoded in the genome of human.


name: RBM3_HUMAN RNA-binding protein 3 (sprot)

description: An RNA-binding protein 3 that is encoded in the genome of human.


name: ZN200_HUMAN Zinc finger protein 200 (sprot)

description: A zinc finger protein 200 that is encoded in the genome of human.


CP4F8_HUMAN Cytochrome P450 4F8 (sprot)

A cytochrome P450 4F8 that is encoded in the genome of human.


name: AT2C1_HUMAN Calcium-transporting ATPase type 2C member 1 (sprot)

description: A calcium-transporting ATPase type 2C member 1 that is encoded in the genome of human.


Golgi calcium ion homeostasis

description: Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings.


Golgi calcium ion transport

description: The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus.


name: trans-Golgi network membrane organization

description: A process which results in the assembly, arrangement of constituent parts, or disassembly of a trans-Golgi network membrane.


name: AT11A_HUMAN Phospholipid-transporting ATPase IH (sprot)

description: A phospholipid-transporting ATPase IH that is encoded in the genome of human.


name: AT8B2_HUMAN Phospholipid-transporting ATPase ID (sprot)

description: A phospholipid-transporting ATPase ID that is encoded in the genome of human.


CYC_HUMAN Cytochrome c (sprot)

A cytochrome c, somatic that is encoded in the genome of human.


respirasome

description: The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.


name: 2ABB_HUMAN Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (sprot)

description: A serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform that is encoded in the genome of human.


name: EM55_HUMAN 55 kDa erythrocyte membrane protein (sprot)

description: A 55 kDa erythrocyte membrane protein that is encoded in the genome of human.


regulation of neutrophil chemotaxis

description: Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.


name: HXA4_HUMAN Homeobox protein Hox-A4 (sprot)

description: A homeobox protein Hox-A4 that is encoded in the genome of human.


name: TFAM_HUMAN Transcription factor A, mitochondrial (sprot)

description: A transcription factor A, mitochondrial that is encoded in the genome of human.


name: PIPNA_HUMAN Phosphatidylinositol transfer protein alpha isoform (sprot)

description: A phosphatidylinositol transfer protein alpha isoform that is encoded in the genome of human.


name: METK1_HUMAN S-adenosylmethionine synthase isoform type-1 (sprot)

description: An S-adenosylmethionine synthetase isoform type-1 that is encoded in the genome of human.


methionine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.


name: S25A3_HUMAN Solute carrier family 25 member 3 (sprot)

description: A solute carrier family 25 member 3 that is encoded in the genome of human.


name: phosphate:proton symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in).


name: mitochondrial phosphate ion transmembrane transport

description: The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion.


VIGLN_HUMAN Vigilin (sprot)

A vigilin that is encoded in the genome of human.


name: TF2B_HUMAN Transcription initiation factor IIB (sprot)

description: A transcription initiation factor IIB that is encoded in the genome of human.


name: transcriptional start site selection at RNA polymerase II promoter

description: Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.


viral transcription

description: The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.


meiotic sister chromatid cohesion

description: The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis.


RNA polymerase II core complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex.


cell division site

description: The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.


name: HXC5_HUMAN Homeobox protein Hox-C5 (sprot)

description: A homeobox protein Hox-C5 that is encoded in the genome of human.


name: CDK3_HUMAN Cyclin-dependent kinase 3 (sprot)

description: A cyclin-dependent kinase 3 that is encoded in the genome of human.


name: CDKL1_HUMAN Cyclin-dependent kinase-like 1 (sprot)

description: A cyclin-dependent kinase-like 1 that is encoded in the genome of human.


name: CDK6_HUMAN Cyclin-dependent kinase 6 (sprot)

description: A cyclin-dependent kinase 6 that is encoded in the genome of human.


FBXO family protein binding

description: Binding to a member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction.


cyclin D2-CDK6 complex

description: A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


name: CDK5_HUMAN Cyclin-dependent kinase 5 (sprot)

description: A cyclin-dependent kinase 5 that is encoded in the genome of human.


ErbB-2 class receptor binding

description: Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2.


cerebellar cortex formation

description: The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


protein kinase 5 complex

description: A protein complex that has protein serine/threonine kinase activity; in mammals composed of catalytic subunit CDK5 and regulatory subunits CDK5R1 or CDK5R2. Contrary to its gene symbol, CDK5 is not cyclin-dependent.


name: CDK16_HUMAN Cyclin-dependent kinase 16 (sprot)

description: A cyclin-dependent kinase 16 that is encoded in the genome of human.


name: CDK17_HUMAN Cyclin-dependent kinase 17 (sprot)

description: A cyclin-dependent kinase 17 that is encoded in the genome of human.


name: PURA_HUMAN Transcriptional activator protein Pur-alpha (sprot)

description: A transcriptional activator protein Pur-alpha that is encoded in the genome of human.


name: dendritic transport of messenger ribonucleoprotein complex

description: The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites.


name: BORG5_HUMAN Cdc42 effector protein 1 (sprot)

description: A Cdc42 effector protein 1 that is encoded in the genome of human.


name: FANCC_HUMAN Fanconi anemia group C protein (sprot)

description: A Fanconi anemia group C protein that is encoded in the genome of human.


NDP_HUMAN Norrin (sprot)

A norrin that is encoded in the genome of human.


retinal pigment epithelium development

description: The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells.


retina blood vessel maintenance

description: A retina homeostatic process preventing the degeneration of a retina blood vessel.


name: CLH1_HUMAN Clathrin heavy chain 1 (sprot)

description: A clathrin heavy chain 1 that is encoded in the genome of human.


name: HSF1_HUMAN Heat shock factor protein 1 (sprot)

description: A heat shock factor protein 1 that is encoded in the genome of human.


name: RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding

description: Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within.


translation elongation factor binding

description: Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation.


name: sequence-specific single stranded DNA binding

description: Binding to single-stranded DNA of a specific nucleotide composition.


name: positive regulation of stress granule assembly

description: Any process that starts or increases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.


cellular response to diamide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus.


cellular response to nitroglycerin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus.


response to hypobaric hypoxia

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level).


name: NFKB2_HUMAN Nuclear factor NF-kappa-B p100 subunit (sprot)

description: A nuclear factor NF-kappa-B p100 subunit that is encoded in the genome of human.


name: FKBP3_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP3 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP3 that is encoded in the genome of human.


name: PLCB2_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (sprot)

description: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 that is encoded in the genome of human.


G-protein beta/gamma-subunit complex

description: The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange.


name: REEP5_HUMAN Receptor expression-enhancing protein 5 (sprot)

description: A receptor expression-enhancing protein 5 that is encoded in the genome of human.


regulation of intracellular transport

description: Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.


name: endoplasmic reticulum membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane.


name: DHSO_HUMAN Sorbitol dehydrogenase (sprot)

description: A sorbitol dehydrogenase that is encoded in the genome of human.


(R,R)-butanediol dehydrogenase activity

description: Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+.


name: L-iditol 2-dehydrogenase (NAD+) activity

description: Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+. Acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol.


D-xylulose reductase activity

description: Catalysis of the reaction: NAD+ + xylitol = D-xylulose + H+ + NADH.


name: D-sorbitol dehydrogenase (acceptor) activity

description: Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor.


ribitol 2-dehydrogenase (NAD+) activity

description: Catalysis of the reaction: D-ribitol + NAD+ = D-ribulose + H+ + NADH.


sorbitol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group.


L-xylitol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group.


L-xylitol metabolic process

description: The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets.


name: HNRPU_HUMAN Heterogeneous nuclear ribonucleoprotein U (sprot)

description: A heterogeneous nuclear ribonucleoprotein U that is encoded in the genome of human.


name: TFIIH-class transcription factor complex binding

description: Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


poly(C) RNA binding

description: Binding to a sequence of cytosine residues in an RNA molecule.


name: protein localization to spindle microtubule

description: A process in which a protein is transported to, or maintained in, a location within a spindle microtubule.


RNA localization to chromatin

description: A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin.


inactive sex chromosome

description: A sex chromosome that has been inactivated.


name: MYPC1_HUMAN Myosin-binding protein C, slow-type (sprot)

description: A myosin-binding protein C, slow-type that is encoded in the genome of human.


name: PSG9_HUMAN Pregnancy-specific beta-1-glycoprotein 9 (sprot)

description: A pregnancy-specific beta-1-glycoprotein 9 that is encoded in the genome of human.


name: tolerance induction dependent upon immune response

description: Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation.


name: PSG4_HUMAN Pregnancy-specific beta-1-glycoprotein 4 (sprot)

description: A pregnancy-specific beta-1-glycoprotein 4 that is encoded in the genome of human.


name: PSG6_HUMAN Pregnancy-specific beta-1-glycoprotein 6 (sprot)

description: A pregnancy-specific beta-1-glycoprotein 6 that is encoded in the genome of human.


name: ECT2L_HUMAN Epithelial cell-transforming sequence 2 oncogene-like (sprot)

description: An epithelial cell-transforming sequence 2 oncogene-like that is encoded in the genome of human.


name: B4GN1_HUMAN Beta-1,4 N-acetylgalactosaminyltransferase 1 (sprot)

description: A beta-1,4 N-acetylgalactosaminyltransferase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide.


name: CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B (sprot)

description: A voltage-dependent N-type calcium channel subunit alpha-1B that is encoded in the genome of human.


name: IRF9_HUMAN Interferon regulatory factor 9 (sprot)

description: An interferon regulatory factor 9 that is encoded in the genome of human.


name: MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (sprot)

description: An E3 ubiquitin-protein ligase Mdm2 that is encoded in the genome of human.


name: traversing start control point of mitotic cell cycle

description: A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity.


cellular response to vitamin B1

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus.


name: negative regulation of signal transduction by p53 class mediator

description: Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator.


response to formaldehyde

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus.


BEX3_HUMAN Protein BEX3 (sprot)

A protein BEX3 that is encoded in the genome of human.


PLIN5_HUMAN Perilipin-5 (sprot)

A perilipin-5 that is encoded in the genome of human.


name: negative regulation of peroxisome proliferator activated receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.


name: PRCD_HUMAN Photoreceptor disk component PRCD (sprot)

description: A photoreceptor disk component PRCD that is encoded in the genome of human.


name: PDE1B_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (sprot)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B that is encoded in the genome of human.


name: U2AF1_HUMAN Splicing factor U2AF 35 kDa subunit (sprot)

description: A splicing factor U2AF 35 kDa subunit that is encoded in the genome of human.


name: SPTB2_HUMAN Spectrin beta chain, non-erythrocytic 1 (sprot)

description: A spectrin beta chain, non-erythrocytic 1 that is encoded in the genome of human.


central nervous system formation

description: The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.


TIAR_HUMAN Nucleolysin TIAR (sprot)

A nucleolysin TIAR that is encoded in the genome of human.


name: E2F1_HUMAN Transcription factor E2F1 (sprot)

description: A transcription factor E2F1 that is encoded in the genome of human.


name: INSM1_HUMAN Insulinoma-associated protein 1 (sprot)

description: An insulinoma-associated protein 1 that is encoded in the genome of human.


SET_HUMAN Protein SET (sprot)

A protein SET that is encoded in the genome of human.


name: IL9R_HUMAN Interleukin-9 receptor (sprot)

description: An interleukin-9 receptor that is encoded in the genome of human.


interleukin-9 receptor activity

description: Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: SCN7A_HUMAN Sodium channel protein type 7 subunit alpha (sprot)

description: A sodium channel protein type 7 subunit alpha that is encoded in the genome of human.


name: SRSF2_HUMAN Serine/arginine-rich splicing factor 2 (sprot)

description: A splicing factor, arginine/serine-rich 2 that is encoded in the genome of human.


interchromatin granule

description: A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs).


CD83_HUMAN CD83 antigen (sprot)

A CD83 molecule that is encoded in the genome of human.


name: FOXK2_HUMAN Forkhead box protein K2 (sprot)

description: A forkhead box protein K2 that is encoded in the genome of human.


name: RUNX1_HUMAN Runt-related transcription factor 1 (sprot)

description: A runt-related transcription factor 1 that is encoded in the genome of human.


name: regulation of connective tissue replacement

description: Any process that modulates the frequency, rate or extent of connective tissue replacement.


core-binding factor complex

description: A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit.


name: RELB_HUMAN Transcription factor RelB (sprot)

description: A transcription factor RelB that is encoded in the genome of human.


lymphocyte differentiation

description: The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.


name: IL5RA_HUMAN Interleukin-5 receptor subunit alpha (sprot)

description: An interleukin-5 receptor subunit alpha that is encoded in the genome of human.


name: FCERB_HUMAN High affinity immunoglobulin epsilon receptor subunit beta (sprot)

description: A high affinity immunoglobulin epsilon receptor subunit beta that is encoded in the genome of human.


name: GALK2_HUMAN N-acetylgalactosamine kinase (sprot)

description: An N-acetylgalactosamine kinase that is encoded in the genome of human.


N-acetylgalactosamine kinase activity

description: Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate.


AMPD3_HUMAN AMP deaminase 3 (sprot)

An AMP deaminase 3 that is encoded in the genome of human.


AMPD2_HUMAN AMP deaminase 2 (sprot)

An AMP deaminase 2 that is encoded in the genome of human.


IMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate.


name: cyclic purine nucleotide metabolic process

description: The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue and the base is a purine.


name: MLRA_HUMAN Myosin regulatory light chain 2, atrial isoform (sprot)

description: A myosin regulatory light chain 2, atrial isoform that is encoded in the genome of human.


name: PMP22_HUMAN Peripheral myelin protein 22 (sprot)

description: A peripheral myelin protein 22 that is encoded in the genome of human.


A di-N-acetylchitobiase that is encoded in the genome of human.


name: FABP5_HUMAN Fatty acid-binding protein 5 (sprot)

description: A fatty acid-binding protein 5 that is encoded in the genome of human.


name: regulation of prostaglandin biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


name: regulation of retrograde trans-synaptic signaling by endocanabinoid

description: Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by an endocannabinoid.


ANK2_HUMAN Ankyrin-2 (sprot)

An ankyrin-2 that is encoded in the genome of human.


protein localization to M-band

description: Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere.


protein localization to T-tubule

description: A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.


name: atrial cardiac muscle cell to AV node cell communication

description: The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


name: SA node cell to atrial cardiac muscle cell communication

description: The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


name: positive regulation of calcium ion transmembrane transporter activity

description: Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity.


name: CAP1_HUMAN Adenylyl cyclase-associated protein 1 (sprot)

description: An adenylyl cyclase-associated protein 1 that is encoded in the genome of human.


DEF5_HUMAN Defensin alpha 5 (sprot)

A protein that is a translation product of the DEFA5 gene in human.


name: positive regulation of membrane permeability

description: Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane.


DEF6_HUMAN Defensin-6 (sprot)

A protein that is a translation product of the DEFA6 gene in human.


name: TSPY1_HUMAN Testis-specific Y-encoded protein 1 (sprot)

description: A testis-specific Y-encoded protein 1 that is encoded in the genome of human.


name: MYT1_HUMAN Myelin transcription factor 1 (sprot)

description: A myelin transcription factor 1 that is encoded in the genome of human.


name: FLI1_HUMAN Friend leukemia integration 1 transcription factor (sprot)

description: A Friend leukemia integration 1 transcription factor that is encoded in the genome of human.


name: K22O_HUMAN Keratin, type II cytoskeletal 2 oral (sprot)

description: A keratin, type II cytoskeletal 2 oral that is encoded in the genome of human.


sebaceous gland development

description: The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure.


name: HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthase, cytoplasmic (sprot)

description: A hydroxymethylglutaryl-CoA synthase, cytoplasmic that is encoded in the genome of human.


name: IFM3_HUMAN Interferon-induced transmembrane protein 3 (sprot)

description: An interferon-induced transmembrane protein that is a translation product of the IFITM3 gene in human.


name: IFM2_HUMAN Interferon-induced transmembrane protein 2 (sprot)

description: An interferon-induced transmembrane protein that is a translation product of the IFITM2 gene in human.


name: ILRL1_HUMAN Interleukin-1 receptor-like 1 (sprot)

description: An interleukin-1 receptor-like 1 that is encoded in the genome of human.


interleukin-33 receptor activity

description: Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: LAT1_HUMAN Large neutral amino acids transporter small subunit 1 (sprot)

description: A large neutral amino acids transporter small subunit 1 that is encoded in the genome of human.


name: L-tryptophan transmembrane transporter activity

description: Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid.


cellular response to L-arginine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus.


L-tryptophan transmembrane transport

description: The directed movement of L-tryptophan across a membrane.


name: positive regulation of L-leucine import across plasma membrane

description: Any process that activates or increases the frequency, rate or extent of L-leucine import across plasma membrane.


NC2B_HUMAN Protein Dr1 (sprot)

A protein Dr1 that is encoded in the genome of human.


name: TFAP4_HUMAN Transcription factor AP-4 (sprot)

description: A transcription factor AP-4 that is encoded in the genome of human.


name: CAC1D_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1D (sprot)

description: A voltage-dependent L-type calcium channel subunit alpha-1D that is encoded in the genome of human.


name: ACTHR_HUMAN Adrenocorticotropic hormone receptor (sprot)

description: An adrenocorticotropic hormone receptor that is encoded in the genome of human.


corticotropin receptor activity

description: Combining with corticotropin to initiate a change in cell activity.


name: MSHR_HUMAN Melanocyte-stimulating hormone receptor (sprot)

description: A melanocyte-stimulating hormone receptor that is encoded in the genome of human.


UV-damage excision repair

description: A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs).


positive regulation of feeding behavior

description: Any process that activates or increases the frequency, rate or extent of feeding behavior.


name: FMO1_HUMAN Flavin-containing monooxygenase 1 (sprot)

description: A flavin-containing monooxygenase 1 that is encoded in the genome of human.


name: EXOSX_HUMAN Exosome complex component 10 (sprot)

description: An exosome complex component 10 that is encoded in the genome of human.


RNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.


CUT catabolic process

description: The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs).


name: nuclear polyadenylation-dependent rRNA catabolic process

description: The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA.


nucleolar exosome (RNase complex)

description: A ribonuclease complex that has 3-prime to 5-prime distributive hydrolytic exoribonuclease activity and in some taxa (e.g. yeast) endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.


name: OTUD4_HUMAN OTU domain-containing protein 4 (sprot)

description: An OTU domain-containing protein 4 that is encoded in the genome of human.


name: regulation of protein K48-linked deubiquitination

description: Any process that modulates the frequency, rate or extent of protein K48-linked deubiquitination.


name: PFKAP_HUMAN ATP-dependent 6-phosphofructokinase, platelet type (sprot)

description: An ATP-dependent 6-phosphofructokinase, platelet type that is encoded in the genome of human.


name: AT2B2_HUMAN Plasma membrane calcium-transporting ATPase 2 (sprot)

description: A plasma membrane calcium-transporting ATPase 2 that is encoded in the genome of human.


name: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration

description: A calcium-transporting P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration.


name: SATB1_HUMAN DNA-binding protein SATB1 (sprot)

description: A DNA-binding protein SATB1 that is encoded in the genome of human.


name: XPC_HUMAN DNA repair protein complementing XP-C cells (sprot)

description: A DNA repair protein complementing XP-C cells that is encoded in the genome of human.


heteroduplex DNA loop binding

description: Binding to a DNA segment containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration.


name: EWS_HUMAN RNA-binding protein EWS (sprot)

description: An RNA-binding protein EWS that is encoded in the genome of human.


name: CDR2_HUMAN Cerebellar degeneration-related protein 2 (sprot)

description: A cerebellar degeneration-related protein 2 that is encoded in the genome of human.


name: PO4F1_HUMAN POU domain, class 4, transcription factor 1 (sprot)

description: A POU domain, class 4, transcription factor 1 that is encoded in the genome of human.


cell migration in hindbrain

description: The orderly movement of a cell that will reside in the hindbrain.


name: proprioception involved in equilibrioception

description: The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity.


name: PO5F1_HUMAN POU domain, class 5, transcription factor 1 (sprot)

description: A POU domain, class 5, transcription factor 1 that is encoded in the genome of human.


name: SPIB_HUMAN Transcription factor Spi-B (sprot)

description: A transcription factor Spi-B that is encoded in the genome of human.


name: BNC1_HUMAN Zinc finger protein basonuclin-1 (sprot)

description: A zinc finger protein basonuclin-1 that is encoded in the genome of human.


name: CO4A3_HUMAN Collagen alpha-3(IV) chain (sprot)

description: A collagen alpha-3(IV) chain that is encoded in the genome of human.


name: SC6A3_HUMAN Sodium-dependent dopamine transporter (sprot)

description: A sodium-dependent dopamine transporter that is encoded in the genome of human.


amine binding

description: Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group.


name: OCRL_HUMAN Inositol polyphosphate 5-phosphatase OCRL (sprot)

description: An inositol polyphosphate 5-phosphatase OCRL that is encoded in the genome of human.


description: Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.


inositol phosphate phosphatase activity

description: Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate.


name: PLCB3_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (sprot)

description: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 that is encoded in the genome of human.


name: ROR1_HUMAN Inactive tyrosine-protein kinase transmembrane receptor ROR1 (sprot)

description: A tyrosine-protein kinase transmembrane receptor ROR1 that is encoded in the genome of human.


name: ROR2_HUMAN Tyrosine-protein kinase transmembrane receptor ROR2 (sprot)

description: A tyrosine-protein kinase transmembrane receptor ROR2 that is encoded in the genome of human.


name: regulation of synaptic signaling by nitric oxide

description: Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide.


TAGL_HUMAN Transgelin (sprot)

A transgelin that is encoded in the genome of human.


name: AK17A_HUMAN A-kinase anchor protein 17A (sprot)

description: An A-kinase anchor protein 17A that is encoded in the genome of human.


MYL5_HUMAN Myosin light chain 5 (sprot)

A myosin light chain 5 that is encoded in the genome of human.


name: MEF2A_HUMAN Myocyte-specific enhancer factor 2A (sprot)

description: A myocyte-specific enhancer factor 2A that is encoded in the genome of human.


mitochondrion distribution

description: Any process that establishes the spatial arrangement of mitochondria between and within cells.


ERK5 cascade

description: A MAPK cascade containing at least the ERK5 MAP kinase (MAPK7; also called BMK1). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK5. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The ERK5 cascade is activated by stress, mitogens, and by G protein-coupled receptors, and results in cellular responses such as cell growth, cell differentiation and development.


name: MEF2B_HUMAN Myocyte-specific enhancer factor 2B (sprot)

description: A myocyte-specific enhancer factor 2B that is encoded in the genome of human.


name: NAAA_HUMAN N-acylethanolamine-hydrolyzing acid amidase (sprot)

description: An N-acylethanolamine-hydrolyzing acid amidase that is encoded in the genome of human.


name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

description: Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.


description: Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid.


ceramidase activity

description: Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid.


N-acylethanolamine metabolic process

description: The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group.


name: SP2_HUMAN Transcription factor Sp2 (sprot)

description: A transcription factor Sp2 that is encoded in the genome of human.


name: RHAG_HUMAN Ammonium transporter Rh type A (sprot)

description: An ammonium transporter Rh type A that is encoded in the genome of human.


name: methylammonium transmembrane transporter activity

description: Enables directed movement of methylammonium, CH3NH2, from one side of a membrane to the other.


leak channel activity

description: Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.


name: GCYA1_HUMAN Guanylate cyclase soluble subunit alpha-1 (sprot)

description: A guanylate cyclase soluble subunit alpha-1 that is encoded in the genome of human.


name: retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission

description: Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.


guanylate cyclase complex, soluble

description: Complex that possesses guanylate cyclase activity and is not bound to a membrane.


name: PYRD_HUMAN Dihydroorotate dehydrogenase (quinone), mitochondrial (sprot)

description: A dihydroorotate dehydrogenase (quinone), mitochondrial that is encoded in the genome of human.


name: dihydroorotate dehydrogenase (quinone) activity

description: (S)-dihydroorotate + a quinone = orotate + a quinol.


name: GCYB1_HUMAN Guanylate cyclase soluble subunit beta-1 (sprot)

description: A guanylate cyclase soluble subunit beta-1 that is encoded in the genome of human.


cytidylate cyclase activity

description: Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H+.


name: trans-synaptic signaling by nitric oxide, modulating synaptic transmission

description: Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse.


name: KPCE_HUMAN Protein kinase C epsilon type (sprot)

description: A protein kinase C epsilon that is encoded in the genome of human.


name: TRAM-dependent toll-like receptor 4 signaling pathway

description: The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.


name: positive regulation of cellular glucuronidation

description: Any process that activates or increases the frequency, rate or extent of cellular glucuronidation.


name: RHD_HUMAN Blood group Rh(D) polypeptide (sprot)

description: A blood group Rh(D) polypeptide that is encoded in the genome of human.


name: ODO1_HUMAN 2-oxoglutarate dehydrogenase complex component E1 (sprot)

description: A 2-oxoglutarate dehydrogenase complex component E1 that is encoded in the genome of human.


name: oxoglutarate dehydrogenase (succinyl-transferring) activity

description: Catalysis of the reaction: 2-oxoglutarate + lipoamide + H+ = S-succinyldihydrolipoamide + CO2.


name: oxoglutarate dehydrogenase (NAD+) activity

description: Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH.


cerebellar cortex development

description: The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


name: CX6A2_HUMAN Cytochrome c oxidase subunit 6A2, mitochondrial (sprot)

description: A cytochrome c oxidase subunit 6A2, mitochondrial that is encoded in the genome of human.


name: TNR17_HUMAN Tumor necrosis factor receptor superfamily member 17 (sprot)

description: A tumor necrosis factor receptor superfamily member 17 that is encoded in the genome of human.


name: CENPE_HUMAN Centromere-associated protein E (sprot)

description: A centromere-associated protein E that is encoded in the genome of human.


name: mitotic chromosome movement towards spindle pole

description: The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis.


name: microtubule plus-end directed mitotic chromosome migration

description: The cell cycle process in which chromosomes that are laterally attached to one or more mitotic spindle microtubules migrate towards the spindle equator via plus-end-directed movement along the microtubules. This process is part of mitotic metaphase plate congression.


name: lateral attachment of mitotic spindle microtubules to kinetochore

description: The cellular process in which sister chromatids become laterally attached to spindle microtubules as part of mitotic metaphase plate congression. Attachment precedes migration along microtubules towards the spindle equator (metaphase plate).


name: KIF23_HUMAN Kinesin-like protein KIF23 (sprot)

description: A kinesin-like protein KIF23 that is encoded in the genome of human.


centralspindlin complex

description: A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals).


CNTN2_HUMAN Contactin-2 (sprot)

A contactin-2 that is encoded in the genome of human.


name: clustering of voltage-gated potassium channels

description: The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode.


name: establishment of protein localization to juxtaparanode region of axon

description: The directed movement of a protein to the juxtaparanode region of an axon.


presynaptic membrane organization

description: A process which results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.


name: MMSA_HUMAN Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (sprot)

description: A methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial that is encoded in the genome of human.


name: methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity

description: Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product.


name: malonate-semialdehyde dehydrogenase (acetylating) activity

description: Catalysis of the reaction: 3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.


thymine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.


valine metabolic process

description: The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid.


thymine metabolic process

description: The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.


name: NRG1_HUMAN Pro-neuregulin-1, membrane-bound isoform (sprot)

description: A pro-neuregulin-1, membrane-bound isoform that is encoded in the genome of human.


ERBB3 signaling pathway

description: The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission.


name: positive regulation of striated muscle cell differentiation

description: Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation.


name: CP27A_HUMAN Sterol 26-hydroxylase, mitochondrial (sprot)

description: A cytochrome P450 27, mitochondrial that is encoded in the genome of human.


cholesterol 26-hydroxylase activity

description: Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol.


description: Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH.


name: PLGB_HUMAN Plasminogen-like protein B (sprot)

description: A plasminogen-like protein B that is encoded in the genome of human.


name: BDH_HUMAN D-beta-hydroxybutyrate dehydrogenase, mitochondrial (sprot)

description: A D-beta-hydroxybutyrate dehydrogenase, mitochondrial that is encoded in the genome of human.


description: Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + H+ + NADH.


name: matrix side of mitochondrial inner membrane

description: The side (leaflet) of the mitochondrial inner membrane that faces the matrix.


name: ID2_HUMAN DNA-binding protein inhibitor ID-2 (sprot)

description: A DNA-binding protein inhibitor ID-2 that is encoded in the genome of human.


name: epithelial cell differentiation involved in mammary gland alveolus development

description: The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus.


name: endodermal digestive tract morphogenesis

description: The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm.


SEMG2_HUMAN Semenogelin-2 (sprot)

A semenogelin-2 that is encoded in the genome of human.


name: ZNF45_HUMAN Zinc finger protein 45 (sprot)

description: A zinc finger protein 45 that is encoded in the genome of human.


name: CO7A1_HUMAN Collagen alpha-1(VII) chain (sprot)

description: A collagen alpha-1(VII) chain that is encoded in the genome of human.


collagen type VII trimer

description: A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue. It binds laminin.


name: APBA1_HUMAN Amyloid-beta A4 precursor protein-binding family A member 1 (sprot)

description: An amyloid-beta A4 precursor protein-binding family A member 1 that is encoded in the genome of human.


DSG1_HUMAN Desmoglein-1 (sprot)

A desmoglein-1 that is encoded in the genome of human.


name: SP4_HUMAN Transcription factor Sp4 (sprot)

description: A transcription factor Sp4 that is encoded in the genome of human.


name: SP3_HUMAN Transcription factor Sp3 (sprot)

description: A transcription factor Sp3 that is encoded in the genome of human.


DSC2_HUMAN Desmocollin-2 (sprot)

A desmocollin-2 that is encoded in the genome of human.


name: cardiac muscle cell-cardiac muscle cell adhesion

description: The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules.


MUC3A_HUMAN Mucin-3A (sprot)

A mucin-3A that is encoded in the genome of human.


OC90_HUMAN Otoconin-90 (sprot)

An otoconin-90 that is encoded in the genome of human.


name: ID3_HUMAN DNA-binding protein inhibitor ID-3 (sprot)

description: A DNA-binding protein inhibitor ID-3 that is encoded in the genome of human.


leptomycin B binding

description: Binding to leptomycin B.


cellular response to leptomycin B

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus.


H11_HUMAN Histone H1.1 (sprot)

A histone H1.1 that is encoded in the genome of human.


name: RL18A_HUMAN Large ribosomal subunit protein eL20 (sprot)

description: A large ribosomal subunit protein eL20 that is encoded in the genome of human.


name: PAX5_HUMAN Paired box protein Pax-5 (sprot)

description: A paired box protein PAX-5 that is encoded in the genome of human.


name: IRF8_HUMAN Interferon regulatory factor 8 (sprot)

description: An interferon regulatory factor 8 that is encoded in the genome of human.


name: plasmacytoid dendritic cell differentiation

description: The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell.


name: HEN1_HUMAN Helix-loop-helix protein 1 (sprot)

description: A helix-loop-helix protein 1 that is encoded in the genome of human.


name: HEN2_HUMAN Helix-loop-helix protein 2 (sprot)

description: A helix-loop-helix protein 2 that is encoded in the genome of human.


name: CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1 (sprot)

description: A voltage-dependent L-type calcium channel subunit beta-1 that is encoded in the genome of human.


name: GHRHR_HUMAN Growth hormone-releasing hormone receptor (sprot)

description: A growth hormone-releasing hormone receptor that is encoded in the genome of human.


name: growth hormone-releasing hormone receptor activity

description: Combining with growth hormone-releasing hormone to initiate a change in cell activity.


name: regulation of intracellular steroid hormone receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.