description: The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.


name: TUSC2_HUMAN Tumor suppressor candidate 2 (sprot)

description: A tumor suppressor candidate 2 that is encoded in the genome of human.


name: neutrophil-mediated killing of gram-negative bacterium

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The directed killing of a gram-negative bacterium by a neutrophil.


name: ST1C4_HUMAN Sulfotransferase 1C4 (sprot)

description: A sulfotransferase 1C4 that is encoded in the genome of human.


name: GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2 (sprot)

description: A gamma-aminobutyric acid type B receptor subunit 2 that is encoded in the genome of human.


name: G protein-coupled GABA receptor activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


name: negative regulation of adenylate cyclase activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.


neuron-glial cell signaling

description: Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine.


G protein-coupled GABA receptor complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein complex which is capable of G protein-coupled GABA receptor activity. In human, it is usually a heterodimer composed of GABA-B receptor subunits 1 and 2.


name: G protein-coupled receptor heterodimeric complex

description: A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR.


GABA receptor complex

description: A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor.


name: MMP23_HUMAN Matrix metalloproteinase-23 (sprot)

description: A matrix metalloproteinase-23 that is encoded in the genome of human.


name: RASF9_HUMAN Ras association domain-containing protein 9 (sprot)

description: A Ras association domain-containing protein 9 that is encoded in the genome of human.


name: trans-Golgi network transport vesicle membrane

description: The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell.


name: DGAT1_HUMAN Diacylglycerol O-acyltransferase 1 (sprot)

description: A diacylglycerol O-acyltransferase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.


description: Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.


description: Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester.


monoacylglycerol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified.


name: very-low-density lipoprotein particle assembly

description: The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle.


name: long-chain fatty-acyl-CoA metabolic process

description: The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


diacylglycerol metabolic process

description: The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.


fatty acid homeostasis

description: Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell.


name: SOAT2_HUMAN Sterol O-acyltransferase 2 (sprot)

description: A sterol O-acyltransferase 2 that is encoded in the genome of human.


sterol O-acyltransferase activity

description: Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester.


cholesterol O-acyltransferase activity

description: Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA.


name: macrophage derived foam cell differentiation

description: The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.


intestinal cholesterol absorption

description: Uptake of cholesterol into the blood by absorption from the small intestine.


name: low-density lipoprotein particle clearance

description: The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


CCNK_HUMAN Cyclin-K (sprot)

A cyclin-K that is encoded in the genome of human.


name: cyclin-dependent protein serine/threonine kinase activity

description: Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.


cyclin K-CDK12 complex

description: A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


cyclin K-CDK13 complex

description: A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


name: DHRS3_HUMAN Short-chain dehydrogenase/reductase 3 (sprot)

description: A short-chain dehydrogenase/reductase 3 that is encoded in the genome of human.


regulation of ossification

description: Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.


cardiac septum morphogenesis

description: The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.


name: DGKI_HUMAN Diacylglycerol kinase iota (sprot)

description: A diacylglycerol kinase iota that is encoded in the genome of human.


name: ATP-dependent diacylglycerol kinase activity

description: Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+.


lipid phosphorylation

description: The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.


name: PAK3_HUMAN Serine/threonine-protein kinase PAK 3 (sprot)

description: A serine/threonine-protein kinase PAK 3 that is encoded in the genome of human.


name: cellular response to organic cyclic compound

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.


name: PRAF3_HUMAN PRA1 family protein 3 (sprot)

description: A PRA1 family protein 3 that is encoded in the genome of human.


name: negative regulation of L-glutamate import across plasma membrane

description: Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell.


name: L-glutamate import across plasma membrane

description: The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol.


presynaptic cytosol

description: The region of the cytosol consisting of all cytosol that is part of the presynapse.


name: RGS9_HUMAN Regulator of G-protein signaling 9 (sprot)

description: A regulator of G-protein signaling 9 that is encoded in the genome of human.


name: regulation of calcium ion export across plasma membrane

description: Any process that modulates the frequency, rate or extent of calcium ion export across the plasma membrane.


name: SERF1_HUMAN Small EDRK-rich factor 1 (sprot)

description: A small EDRK-rich factor 1 that is encoded in the genome of human.


DYSF_HUMAN Dysferlin (sprot)

A dysferlin that is encoded in the genome of human.


name: monocyte activation involved in immune response

description: The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


name: macrophage activation involved in immune response

description: A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


name: PIAS1_HUMAN E3 SUMO-protein ligase PIAS1 (sprot)

description: An E3 SUMO-protein ligase PIAS1 that is encoded in the genome of human.


name: positive regulation of protein sumoylation

description: Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein.


name: positive regulation of smooth muscle cell differentiation

description: Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation.


protein-DNA complex assembly

description: The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.


name: positive regulation of protein localization to cell periphery

description: Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery.


nuclear periphery

description: The portion of the nuclear lumen proximal to the inner nuclear membrane.


name: PIAS2_HUMAN E3 SUMO-protein ligase PIAS2 (sprot)

description: An E3 SUMO-protein ligase PIAS2 that is encoded in the genome of human.


name: SPF27_HUMAN Pre-mRNA-splicing factor SPF27 (sprot)

description: A pre-mRNA-splicing factor SPF27 that is encoded in the genome of human.


DCTN3_HUMAN Dynactin subunit 3 (sprot)

A dynactin subunit 3 that is encoded in the genome of human.


microtubule-based process

description: Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.


cytoskeleton-dependent cytokinesis

description: A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton.


dynactin complex

description: A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach.


name: BODG_HUMAN Gamma-butyrobetaine dioxygenase (sprot)

description: A gamma-butyrobetaine dioxygenase that is encoded in the genome of human.


description: Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O2 = carnitine + CO2 + succinate.


carnitine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.


name: DNJC8_HUMAN DnaJ homolog subfamily C member 8 (sprot)

description: A DnaJ homolog subfamily C member 8 that is encoded in the genome of human.


name: SPF30_HUMAN Survival of motor neuron-related-splicing factor 30 (sprot)

description: A survival of motor neuron-related-splicing factor 30 that is encoded in the genome of human.


name: RAD17_HUMAN Cell cycle checkpoint protein RAD17 (sprot)

description: A cell cycle checkpoint protein RAD17 that is encoded in the genome of human.


name: mitotic intra-S DNA damage checkpoint signaling

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.


Rad17 RFC-like complex

description: A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.


name: ATP5H_HUMAN ATP synthase subunit d, mitochondrial (sprot)

description: An ATP synthase subunit d, mitochondrial that is encoded in the genome of human.


name: proton-transporting ATP synthase activity, rotational mechanism

description: Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out).


name: proton motive force-driven ATP synthesis

description: The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.


name: mitochondrial proton-transporting ATP synthase complex

description: A proton-transporting ATP synthase complex found in the mitochondrial membrane.


name: LYZL6_HUMAN Lysozyme-like protein 6 (sprot)

description: A lysozyme-like protein 6 that is encoded in the genome of human.


sperm plasma membrane

description: A plasma membrane that is part of a sperm cell.


name: CABYR_HUMAN Calcium-binding tyrosine phosphorylation-regulated protein (sprot)

description: A calcium-binding tyrosine phosphorylation-regulated protein that is encoded in the genome of human.


name: epithelial cilium movement involved in extracellular fluid movement

description: The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.


sperm fibrous sheath

description: A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat.


name: DNJB5_HUMAN DnaJ homolog subfamily B member 5 (sprot)

description: A DnaJ homolog subfamily B member 5 that is encoded in the genome of human.


TSN9_HUMAN Tetraspanin-9 (sprot)

A tetraspanin-9 that is encoded in the genome of human.


FLOT1_HUMAN Flotillin-1 (sprot)

A flotillin-1 that is encoded in the genome of human.


name: regulation of toll-like receptor 4 signaling pathway

description: Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway.


plasma membrane raft organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of plasma membrane rafts.


regulation of receptor internalization

description: Any process that modulates the frequency, rate or extent of receptor internalization.


name: positive regulation of synaptic transmission, dopaminergic

description: Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.


dsRNA transport

description: The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: positive regulation of heterotypic cell-cell adhesion

description: Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion.


plasma membrane raft assembly

description: The aggregation, arrangement and bonding together of a set of components to form a plasma membrane raft.


name: positive regulation of skeletal muscle tissue development

description: Any process that activates, maintains or increases the rate of skeletal muscle tissue development.


protein kinase C signaling

description: A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.


name: positive regulation of cell-cell adhesion mediated by cadherin

description: Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin.


cell-cell contact zone

description: Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle.


flotillin complex

description: A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae.


name: CDKA2_HUMAN Cyclin-dependent kinase 2-associated protein 2 (sprot)

description: A cyclin-dependent kinase 2-associated protein 2 that is encoded in the genome of human.


name: regulation of microtubule cytoskeleton organization

description: Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.


regulation of stem cell division

description: Any process that modulates the frequency, rate or extent of stem cell division.


name: TRIO_HUMAN Triple functional domain protein (sprot)

description: A triple functional domain protein that is encoded in the genome of human.


name: cell surface receptor protein tyrosine phosphatase signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: postsynaptic modulation of chemical synaptic transmission

description: Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.


name: ATP5L_HUMAN ATP synthase subunit g, mitochondrial (sprot)

description: An ATP synthase subunit g, mitochondrial that is encoded in the genome of human.


name: AKAP3_HUMAN A-kinase anchor protein 3 (sprot)

description: An A-kinase anchor protein 3 that is encoded in the genome of human.


name: cell surface receptor protein serine/threonine kinase signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: MPDZ_HUMAN Multiple PDZ domain protein (sprot)

description: A multiple PDZ domain protein that is encoded in the genome of human.


name: SNPC5_HUMAN snRNA-activating protein complex subunit 5 (sprot)

description: An snRNA-activating protein complex subunit 5 that is encoded in the genome of human.


name: RNA polymerase III general transcription initiation factor activity

description: A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III.


name: transcription initiation at RNA polymerase III promoter

description: A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III.


name: snRNA transcription by RNA polymerase III

description: The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter.


C1QRF_HUMAN C1q-related factor (sprot)

A C1q-related factor that is encoded in the genome of human.


climbing fiber

description: The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to climb along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber.


CBPD_HUMAN Carboxypeptidase D (sprot)

A carboxypeptidase D that is encoded in the genome of human.


serine-type carboxypeptidase activity

description: Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


name: SASH3_HUMAN SAM and SH3 domain-containing protein 3 (sprot)

description: A SAM and SH3 domain-containing protein 3 that is encoded in the genome of human.


B cell proliferation

description: The expansion of a B cell population by cell division. Follows B cell activation.


name: CD4-positive, alpha-beta T cell differentiation

description: The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.


positive regulation of organ growth

description: Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.


name: homeostasis of number of cells within a tissue

description: Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.


name: OR2B3_HUMAN Putative olfactory receptor 2B3 (sprot)

description: A putative olfactory receptor 2B3 that is encoded in the genome of human.


name: OR2J3_HUMAN Olfactory receptor 2J3 (sprot)

description: An olfactory receptor 2J3 that is encoded in the genome of human.


name: OR2J2_HUMAN Olfactory receptor 2J2 (sprot)

description: An olfactory receptor 2J2 that is encoded in the genome of human.


GLRX3_HUMAN Glutaredoxin-3 (sprot)

A glutaredoxin-3 that is encoded in the genome of human.


iron-sulfur cluster binding

description: Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.


name: regulation of the force of heart contraction

description: Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.


name: negative regulation of cardiac muscle hypertrophy

description: Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.


name: protein maturation by iron-sulfur cluster transfer

description: The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.


name: KT33A_HUMAN Keratin, type I cuticular Ha3-I (sprot)

description: A keratin, type I cuticular Ha3-I that is encoded in the genome of human.


name: KRT34_HUMAN Keratin, type I cuticular Ha4 (sprot)

description: A keratin, type I cuticular Ha4 that is encoded in the genome of human.


name: KRT36_HUMAN Keratin, type I cuticular Ha6 (sprot)

description: A keratin, type I cuticular Ha6 that is encoded in the genome of human.


name: KRT37_HUMAN Keratin, type I cuticular Ha7 (sprot)

description: A keratin, type I cuticular Ha7 that is encoded in the genome of human.


name: KRT38_HUMAN Keratin, type I cuticular Ha8 (sprot)

description: A keratin, type I cuticular Ha8 that is encoded in the genome of human.


name: RL1D1_HUMAN Ribosomal L1 domain-containing protein 1 (sprot)

description: A ribosomal L1 domain-containing protein 1 that is encoded in the genome of human.


WFS1_HUMAN Wolframin (sprot)

A wolframin that is encoded in the genome of human.


ER overload response

description: The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB.


nervous system process

description: A organ system process carried out by any of the organs or tissues of neurological system.


name: negative regulation of response to endoplasmic reticulum stress

description: Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress.


name: negative regulation of ATF6-mediated unfolded protein response

description: Any process that stops, prevents or reduces the frequency, rate or extent of the ATF6-mediated unfolded protein response.


name: negative regulation of type B pancreatic cell apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process.


ANXA9_HUMAN Annexin A9 (sprot)

An annexin A9 that is encoded in the genome of human.


acetylcholine receptor activity

description: Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


synaptic transmission, cholinergic

description: The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


name: CLPX_HUMAN ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (sprot)

description: An ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial that is encoded in the genome of human.


ATP-dependent peptidase activity

description: Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis.


peptidase activator activity

description: Binds to and increases the activity of a peptidase.


name: proteolysis involved in protein catabolic process

description: The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.


endopeptidase Clp complex

description: A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form.


mitochondrial endopeptidase Clp complex

description: A Clp endopeptidase complex located in the mitochondrion.


name: NCTR1_HUMAN Natural cytotoxicity triggering receptor 1 (sprot)

description: A natural cytotoxicity triggering receptor 1 that is encoded in the genome of human.


name: regulation of natural killer cell mediated cytotoxicity

description: Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.


SEGN_HUMAN Secretagogin (sprot)

A secretagogin that is encoded in the genome of human.


transport vesicle membrane

description: The lipid bilayer surrounding a transport vesicle.


name: CDKL5_HUMAN Cyclin-dependent kinase-like 5 (sprot)

description: A cyclin-dependent kinase-like 5 that is encoded in the genome of human.


regulation of dendrite development

description: Any process that modulates the frequency, rate or extent of dendrite development.


NEBL_HUMAN Nebulette (sprot)

A nebulette that is encoded in the genome of human.


cardiac muscle thin filament assembly

description: The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle.


name: ERIT1_HUMAN Putative uncharacterized protein encoded by ERC2-IT1 (sprot)


name: NEUL1_HUMAN E3 ubiquitin-protein ligase NEURL1 (sprot)

description: An E3 ubiquitin-protein ligase NEURL1 that is encoded in the genome of human.


name: translation factor activity, non-nucleic acid binding

description: A translation regulator activity that does not involve binding to nucleic acids.


name: positive regulation of long-term neuronal synaptic plasticity

description: A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.


name: positive regulation of synapse maturation

description: Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.


name: S14L2_HUMAN SEC14-like protein 2 (sprot)

description: A SEC14-like protein 2 that is encoded in the genome of human.


vitamin E binding

description: Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.


STC2_HUMAN Stanniocalcin-2 (sprot)

A stanniocalcin-2 that is encoded in the genome of human.


name: regulation of store-operated calcium entry

description: Any process that modulates the frequency, rate or extent of store-operated calcium entry.


name: ERG24_HUMAN Delta(14)-sterol reductase TM7SF2 (sprot)

description: A Delta(14)-sterol reductase TM7SF2 that is encoded in the genome of human.


delta14-sterol reductase activity

description: Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol.


name: RNF8_HUMAN E3 ubiquitin-protein ligase RNF8 (sprot)

description: An E3 ubiquitin-protein ligase RNF8 that is encoded in the genome of human.


response to ionizing radiation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.


SYUG_HUMAN Gamma-synuclein (sprot)

A gamma-synuclein that is encoded in the genome of human.


protein secretion

description: The controlled release of proteins from a cell.


name: regulation of neurotransmitter secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.


name: CIAO1_HUMAN Probable cytosolic iron-sulfur protein assembly protein CIAO1 (sprot)

description: A protein CIAO1 that is encoded in the genome of human.


MMXD complex

description: A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation.


name: cytosolic [4Fe-4S] assembly targeting complex

description: A protein complex capable of condensing two 2Fe-2S clusters into one 4Fe-4S center in the cytoplasm and nucleus. In humans it consists of MMS19, CIAO1, CIAO2A/CIAO2B, CIAO3. MMS19, CIAO1 and CIAO2A/CIAO2B form a tight 'core' complex, whereas CIAO3 is an 'external' component of this complex.


name: PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (sprot)

description: A cGMP-specific 3',5'-cyclic phosphodiesterase that is encoded in the genome of human.


description: Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate.


name: regulation of nitric oxide mediated signal transduction

description: Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).


name: negative regulation of cardiac muscle contraction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction.


relaxation of cardiac muscle

description: The process in which the extent of cardiac muscle contraction is reduced.


name: positive regulation of oocyte development

description: Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.


name: DFFB_HUMAN DNA fragmentation factor subunit beta (sprot)

description: A DNA fragmentation factor subunit beta that is encoded in the genome of human.


DNA endonuclease activity

description: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.


DNA nuclease activity

description: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.


DNA catabolic process

description: The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.


CCN5_HUMAN CCN family member 5 (sprot)

A CCN family member 5 that is encoded in the genome of human.


name: ZFAN5_HUMAN AN1-type zinc finger protein 5 (sprot)

description: An AN1-type zinc finger protein 5 that is encoded in the genome of human.


smooth muscle tissue development

description: The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure.


name: RGS20_HUMAN Regulator of G-protein signaling 20 (sprot)

description: A regulator of G-protein signaling 20 that is encoded in the genome of human.


name: S22A5_HUMAN Organic cation/carnitine transporter 2 (sprot)

description: An organic cation/carnitine transporter 2 that is encoded in the genome of human.


name: amino-acid betaine transmembrane transporter activity

description: Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid.


name: carnitine transmembrane transporter activity

description: Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.


response to symbiotic bacterium

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism.


carnitine transport

description: The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.


name: positive regulation of intestinal epithelial structure maintenance

description: Any process the increases the rate, frequency or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.


name: sodium-dependent organic cation transport

description: The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


(R)-carnitine transport

description: The directed movement of a (R)-carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: PDE9A_HUMAN High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (sprot)

description: A high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A that is encoded in the genome of human.


cGMP metabolic process

description: The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate.


GAGE7_HUMAN G antigen 7 (sprot)

A G antigen 7 that is encoded in the genome of human.


BEST1_HUMAN Bestrophin-1 (sprot)

A bestrophin-1 that is encoded in the genome of human.


name: bicarbonate transmembrane transporter activity

description: Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.


ligand-gated channel activity

description: Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.


bicarbonate channel activity

description: Enables the energy-independent facilitated diffusion of bicarbonate through a transmembrane aqueous pore or channel.


transepithelial chloride transport

description: The directed movement of chloride ions from one side of an epithelium to the other.


name: gamma-aminobutyric acid secretion, neurotransmission

description: The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter.


membrane microdomain

description: A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it.


name: FGF18_HUMAN Fibroblast growth factor 18 (sprot)

description: A fibroblast growth factor 18 that is encoded in the genome of human.


intramembranous ossification

description: Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.


name: SRP72_HUMAN Signal recognition particle subunit SRP72 (sprot)

description: A signal recognition particle subunit SRP72 that is encoded in the genome of human.


signal recognition particle binding

description: Binding to a signal recognition particle.


7S RNA binding

description: Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP).


name: signal recognition particle, endoplasmic reticulum targeting

description: A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana.


signal recognition particle

description: A complex of protein and RNA which facilitates translocation of proteins across membranes.


JTB_HUMAN Protein JTB (sprot)

A protein JTB that is encoded in the genome of human.


CYTF_HUMAN Cystatin-F (sprot)

A cystatin-F that is encoded in the genome of human.


name: negative regulation of peptidase activity

description: Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.


multivesicular body

description: A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.


name: OR7C1_HUMAN Olfactory receptor 7C1 (sprot)

description: An olfactory receptor 7C1 that is encoded in the genome of human.


name: OR7AA_HUMAN Olfactory receptor 7A10 (sprot)

description: An olfactory receptor 7A10 that is encoded in the genome of human.


name: DXO_HUMAN Decapping and exoribonuclease protein (sprot)

description: A decapping and exoribonuclease protein that is encoded in the genome of human.


5'-3' exonuclease activity

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.


mRNA 5'-diphosphatase activity

description: Catalysis of the removal of a 5' terminal diphosphate from the 5'-triphosphate end of an mRNA, leaving a 5'-monophosphate end.


name: RNA NAD+-cap (NAD+-forming) hydrolase activity

description: Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H+ + NAD+.


RNA destabilization

description: Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes.


nuclear mRNA surveillance

description: A process that identifies and degrades defective or aberrant mRNAs within the nucleus.


NAD-cap decapping

description: Cleavage of the 5'-NAD-cap of an RNA. The NAD-cap is present at the 5'-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes.


name: TRPM2_HUMAN Transient receptor potential cation channel subfamily M member 2 (sprot)

description: A transient receptor potential cation channel subfamily M member 2 that is encoded in the genome of human.


ADP-ribose diphosphatase activity

description: Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.


name: manganese ion transmembrane transporter activity

description: Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.


mono-ADP-D-ribose binding

description: Binding to monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment.


ligand-gated calcium channel activity

description: Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.


response to purine-containing compound

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus.


regulation of filopodium assembly

description: Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.


name: cellular response to purine-containing compound

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus.


name: cellular response to temperature stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.


dendritic cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.


name: DDAH1_HUMAN N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (sprot)

description: An N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 that is encoded in the genome of human.


dimethylargininase activity

description: Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline.


citrulline metabolic process

description: The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.


name: regulation of systemic arterial blood pressure

description: The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.


arginine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.


name: nitric oxide mediated signal transduction

description: An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.


name: negative regulation of cellular response to hypoxia

description: Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia.


name: RECQ4_HUMAN ATP-dependent DNA helicase Q4 (sprot)

description: An ATP-dependent DNA helicase Q4 that is encoded in the genome of human.


3'-5' DNA helicase activity

description: Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis.


bubble DNA binding

description: Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA.


telomeric D-loop binding

description: Binding to a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus.


DNA/DNA annealing activity

description: An activity that facilitates the formation of a complementary double-stranded DNA molecule.


telomeric D-loop disassembly

description: A telomere loop disassembly process that results in the disassembly of telomeric D-loops. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus.


name: RECQ5_HUMAN ATP-dependent DNA helicase Q5 (sprot)

description: An ATP-dependent DNA helicase Q5 that is encoded in the genome of human.


RNA polymerase II complex binding

description: Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.


chromosome separation

description: The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).


cellular response to camptothecin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus.


name: replication-born double-strand break repair via sister chromatid exchange

description: The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks.


mitotic DNA-templated DNA replication

description: A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands during the mitotic cell cycle.


transcription preinitiation complex

description: A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.


name: RMP_HUMAN Unconventional prefoldin RPB5 interactor 1 (sprot)

description: An unconventional prefoldin RPB5 interactor 1 that is encoded in the genome of human.


name: negative regulation of phosphatase activity

description: Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.


name: B3GA3_HUMAN Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (sprot)

description: A galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 that is encoded in the genome of human.


name: chondroitin sulfate proteoglycan biosynthetic process

description: The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.


name: dermatan sulfate proteoglycan biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.


description: Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.


name: positive regulation of catalytic activity

description: Any process that activates or increases the activity of an enzyme.


name: ST17B_HUMAN Serine/threonine-protein kinase 17B (sprot)

description: A serine/threonine-protein kinase 17B that is encoded in the genome of human.


name: ECM2_HUMAN Extracellular matrix protein 2 (sprot)

description: An extracellular matrix protein 2 that is encoded in the genome of human.


interstitial matrix

description: A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens.


name: LY6H_HUMAN Lymphocyte antigen 6H (sprot)

description: A lymphocyte antigen 6H that is encoded in the genome of human.


name: MTA2_HUMAN Metastasis-associated protein MTA2 (sprot)

description: A metastasis-associated protein MTA2 that is encoded in the genome of human.


regulation of fibroblast migration

description: Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.


regulation of cell fate specification

description: Any process that mediates the adoption of a specific fate by a cell.


regulation of stem cell differentiation

description: Any process that modulates the frequency, rate or extent of stem cell differentiation.


name: DPM2_HUMAN Dolichol phosphate-mannose biosynthesis regulatory protein (sprot)

description: A dolichol phosphate-mannose biosynthesis regulatory protein that is encoded in the genome of human.


description: An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast.


AQP8_HUMAN Aquaporin-8 (sprot)

An aquaporin-8 that is encoded in the genome of human.


ammonium channel activity

description: Enables the energy-independent facilitated diffusion of ammonium through a transmembrane aqueous pore or channel.


methylammonium channel activity

description: Enables the energy-independent facilitated diffusion of methylammonium through a transmembrane aqueous pore or channel. Methylammonium is CH3NH2.


urea transport

description: The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2.


methylammonium transport

description: The directed movement of methylammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


transepithelial water transport

description: The directed movement of water (H2O) from one side of an epithelium to the other.


ammonium transmembrane transport

description: The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+.


methylammonium transmembrane transport

description: The process in which methylammonium is transported across a membrane.


name: hydrogen peroxide transmembrane transport

description: The process in which hydrogen peroxide is transported across a membrane.


ammonium import across plasma membrane

description: The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol.


smooth endoplasmic reticulum

description: The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.


intracellular canaliculus

description: An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates.


CNTN5_HUMAN Contactin-5 (sprot)

A contactin-5 that is encoded in the genome of human.


name: UBP1_HUMAN Ubiquitin carboxyl-terminal hydrolase 1 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 1 that is encoded in the genome of human.


description: The removal of the ubiquitin group from a monoubiquitinated protein.


name: positive regulation of error-prone translesion synthesis

description: Any process that activates or increases the frequency, rate or extent of error-prone translesion synthesis.


name: AL1A2_HUMAN Retinal dehydrogenase 2 (sprot)

description: A retinal dehydrogenase 2 that is encoded in the genome of human.


name: 3-chloroallyl aldehyde dehydrogenase activity

description: Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.


retinal binding

description: Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina.


retinoic acid biosynthetic process

description: The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.


vitamin A metabolic process

description: The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene.


midgut development

description: The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.


determination of bilateral symmetry

description: The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.


response to cytokine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.


ureter maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut.


retinal metabolic process

description: The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.


name: 9-cis-retinoic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative.


embryonic digestive tract development

description: The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus.


cardiac muscle tissue development

description: The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.


name: regulation of vascular endothelial cell proliferation

description: Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation.


name: STK10_HUMAN Serine/threonine-protein kinase 10 (sprot)

description: A serine/threonine-protein kinase 10 that is encoded in the genome of human.


lymphocyte aggregation

description: The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules.


regulation of lymphocyte migration

description: Any process that modulates the frequency, rate or extent of lymphocyte migration.


name: ACL6B_HUMAN Actin-like protein 6B (sprot)

description: An actin-like protein 6B that is encoded in the genome of human.


RSC-type complex

description: A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining.


GBAF complex

description: A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM.


name: KPCD3_HUMAN Serine/threonine-protein kinase D3 (sprot)

description: A serine/threonine-protein kinase D3 that is encoded in the genome of human.


name: diacylglycerol-dependent serine/threonine kinase activity

description: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.


name: GFPT2_HUMAN Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (sprot)

description: A glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 that is encoded in the genome of human.


name: glutamine-fructose-6-phosphate transaminase (isomerizing) activity

description: Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.


carbohydrate derivative binding

description: Binding to a carbohydrate derivative.


description: The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


energy reserve metabolic process

description: The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen.


name: RGS11_HUMAN Regulator of G-protein signaling 11 (sprot)

description: A regulator of G-protein signaling 11 that is encoded in the genome of human.


name: TPPP_HUMAN Tubulin polymerization-promoting protein (sprot)

description: A tubulin polymerization-promoting protein that is encoded in the genome of human.


microtubule bundle

description: An arrangement of closely apposed microtubules running parallel to each other.


microtubule nucleator activity

description: The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly.


oligodendrocyte development

description: The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.


astral microtubule organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.


name: positive regulation of protein polymerization

description: Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.


myelin assembly

description: The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system.


name: microtubule nucleation by microtubule organizing center

description: The 'de novo' formation of a microtubule, mediated by the microtubule organizing center.


name: negative regulation of tubulin deacetylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation.


postsynaptic Golgi apparatus

description: The network of the Golgi apparatus structures located within the postsynapse.


name: BAIP3_HUMAN BAI1-associated protein 3 (sprot)

description: A BAI1-associated protein 3 that is encoded in the genome of human.


name: positive regulation of neurotransmitter secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.


name: regulation of dense core granule exocytosis

description: Any process that modulates the frequency, rate or extent of dense core granule exocytosis.


dense core granule maturation

description: Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis.


name: SLIT2_HUMAN Slit homolog 2 protein (sprot)

description: A slit homolog 2 protein that is encoded in the genome of human.


laminin-1 binding

description: Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1.


proteoglycan binding

description: Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


name: negative regulation of leukocyte chemotaxis

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.


name: negative regulation of lamellipodium assembly

description: Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.


name: negative regulation of smooth muscle cell migration

description: Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.


name: chemorepulsion involved in postnatal olfactory bulb interneuron migration

description: The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration.


name: corticospinal neuron axon guidance through spinal cord

description: The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues.


induction of negative chemotaxis

description: Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical.


name: negative regulation of small GTPase mediated signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction.


cellular response to heparin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus.


name: negative regulation of smooth muscle cell chemotaxis

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis.


name: negative regulation of mononuclear cell migration

description: Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.


name: negative regulation of neutrophil chemotaxis

description: Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.


name: negative regulation of retinal ganglion cell axon guidance

description: Any process that decreases the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.


name: ATG12_HUMAN Ubiquitin-like protein ATG12 (sprot)

description: A ubiquitin-like protein ATG12 that is encoded in the genome of human.


regulation of autophagosome maturation

description: Any process that modulates the frequency, rate or extent of autophagosome maturation.


name: positive regulation of viral translation

description: Any process that activates or increases the frequency, rate or extent of viral translation.


Atg12-Atg5-Atg16 complex

description: A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p.


transferase complex

description: A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).


NOL4_HUMAN Nucleolar protein 4 (sprot)

A nucleolar protein 4 that is encoded in the genome of human.


name: LTN1_HUMAN E3 ubiquitin-protein ligase listerin (sprot)

description: An E3 ubiquitin-protein ligase listerin that is encoded in the genome of human.


name: AT10B_HUMAN Phospholipid-transporting ATPase VB (sprot)

description: A phospholipid-transporting ATPase VB that is encoded in the genome of human.


lysosomal membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.


name: TOM70_HUMAN Mitochondrial import receptor subunit TOM70 (sprot)

description: A mitochondrial import receptor subunit TOM70 that is encoded in the genome of human.


name: mitochondrion targeting sequence binding

description: Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion.


name: protein import into mitochondrial matrix

description: The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.


name: negative regulation of cell growth involved in cardiac muscle cell development

description: Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.


response to thyroxine

description: A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus.


TOM complex

description: A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. TOM transports beta-barrel precursors across the outer membrane and the sorting and assembly machinery (SAM complex) inserts them into the target membrane.


name: mitochondrial outer membrane translocase complex

description: A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments.


name: PKHG5_HUMAN Pleckstrin homology domain-containing family G member 5 (sprot)

description: A pleckstrin homology domain-containing family G member 5 that is encoded in the genome of human.


IPO13_HUMAN Importin-13 (sprot)

An importin-13 that is encoded in the genome of human.


DDHD2_HUMAN Phospholipase DDHD2 (sprot)

A phospholipase DDHD2 that is encoded in the genome of human.


triglyceride catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.


name: MYO1D_HUMAN Unconventional myosin-Id (sprot)

description: A myosin-Id that is encoded in the genome of human.


cellular localization

description: A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.


axolemma

description: The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness.


name: TOX4_HUMAN TOX high mobility group box family member 4 (sprot)

description: A TOX high mobility group box family member 4 that is encoded in the genome of human.


name: RHBT1_HUMAN Rho-related BTB domain-containing protein 1 (sprot)

description: A Rho-related BTB domain-containing protein 1 that is encoded in the genome of human.


DEND_HUMAN Dendrin (sprot)

A dendrin that is encoded in the genome of human.


name: MICA2_HUMAN [F-actin]-monooxygenase MICAL2 (sprot)

description: An [F-actin]-monooxygenase MICAL2 that is encoded in the genome of human.


monooxygenase activity

description: Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.


sulfur oxidation

description: The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur.


actin filament depolymerization

description: Disassembly of actin filaments by the removal of actin monomers from a filament.


name: K0754_HUMAN Microtubule-actin cross-linking factor 1, isoforms 6/7 (sprot)


name: SC24D_HUMAN Protein transport protein Sec24D (sprot)

description: A protein transport protein Sec24D that is encoded in the genome of human.


NFASC_HUMAN Neurofascin (sprot)

A neurofascin that is encoded in the genome of human.


name: ST65G_HUMAN STAGA complex 65 subunit gamma (sprot)

description: A STAGA complex 65 subunit gamma that is encoded in the genome of human.


name: maintenance of protein location in nucleus

description: Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus.


name: FCSD2_HUMAN F-BAR and double SH3 domains protein 2 (sprot)

description: An F-BAR and double SH3 domains protein 2 that is encoded in the genome of human.


name: positive regulation of Arp2/3 complex-mediated actin nucleation

description: Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation.


stereocilium shaft

description: The shaft comprises the majority of the length of the stereocilium. This region is notable for the extreme stability of actin filaments, which are highly crosslinked into a parallel bundle.


name: UFL1_HUMAN E3 UFM1-protein ligase 1 (sprot)

description: An E3 UFM1-protein ligase 1 that is encoded in the genome of human.


protein ufmylation

description: Covalent attachment of the ubiquitin-like protein UFM1 to another protein.


UFM1 ligase activity

description: Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S = X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate.


name: negative regulation of T cell mediated immune response to tumor cell

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell.


name: regulation of intracellular estrogen receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.


name: positive regulation of glial cell proliferation

description: Any process that activates or increases the rate or extent of glial cell proliferation.


reticulophagy

description: The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.


positive regulation of reticulophagy

description: Any process that increases the frequency, rate or extent of reticulophagy.


response to L-glutamate

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus.


name: negative regulation of IRE1-mediated unfolded protein response

description: Any process that stops, prevents or reduces the frequency, rate or extent of the IRE1-mediated unfolded protein response.


protein K69-linked ufmylation

description: A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein.


name: SRBS2_HUMAN Sorbin and SH3 domain-containing protein 2 (sprot)

description: A sorbin and SH3 domain-containing protein 2 that is encoded in the genome of human.


name: TMCC1_HUMAN Transmembrane and coiled-coil domains protein 1 (sprot)

description: A transmembrane and coiled-coil domains protein 1 that is encoded in the genome of human.


endosome membrane tubulation

description: A membrane tubulation process occurring in an endosome membrane.


endosome fission

description: The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane.


name: endoplasmic reticulum-endosome membrane contact site

description: A contact site between the endoplasmic reticulum membrane and the endosome membrane.


name: PHF14_HUMAN PHD finger protein 14 (sprot)

description: A PHD finger protein 14 that is encoded in the genome of human.


germinal center B cell differentiation

description: The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).


name: mesenchymal cell proliferation involved in lung development

description: The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


name: negative regulation of mesenchymal cell proliferation

description: Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


name: negative regulation of platelet-derived growth factor receptor-alpha signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway.


name: SASH1_HUMAN SAM and SH3 domain-containing protein 1 (sprot)

description: A SAM and SH3 domain-containing protein 1 that is encoded in the genome of human.


name: positive regulation of lipopolysaccharide-mediated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.


name: regulation of protein K63-linked ubiquitination

description: Any process that modulates the frequency, rate or extent of protein K63-linked ubiquitination.


name: regulation of protein autoubiquitination

description: Any process that modulates the frequency, rate or extent of protein autoubiquitination.


regulation of epithelial cell migration

description: Any process that modulates the frequency, rate or extent of epithelial cell migration.


CSCL1_HUMAN CSC1-like protein 1 (sprot)

A CSC1-like protein 1 that is encoded in the genome of human.


name: osmolarity-sensing monoatomic cation channel activity

description: Enables the transmembrane transfer of a monoatomic cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides.


surfactant secretion

description: The regulated release of surfactant by a cell or tissue.


name: FARP2_HUMAN FERM, ARHGEF and pleckstrin domain-containing protein 2 (sprot)

description: A FERM, ARHGEF and pleckstrin domain-containing protein 2 that is encoded in the genome of human.


hair cycle process

description: A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.


regulation of integrin activation

description: Any process that modulates the frequency, rate, or extent of integrin activation.


name: UBXN7_HUMAN UBX domain-containing protein 7 (sprot)

description: A UBX domain-containing protein 7 that is encoded in the genome of human.


VCP-NPL4-UFD1 AAA ATPase complex

description: A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).


name: KLH18_HUMAN Kelch-like protein 18 (sprot)

description: A kelch-like protein 18 that is encoded in the genome of human.


name: positive regulation of mitotic cell cycle phase transition

description: Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition.


name: ZN432_HUMAN Zinc finger protein 432 (sprot)

description: A zinc finger protein 432 that is encoded in the genome of human.


name: LRIG2_HUMAN Leucine-rich repeats and immunoglobulin-like domains protein 2 (sprot)

description: A leucine-rich repeats and immunoglobulin-like domains protein 2 that is encoded in the genome of human.


name: regulation of platelet-derived growth factor receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.


name: negative regulation of membrane protein ectodomain proteolysis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.


innervation

description: The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue.


name: TOX_HUMAN Thymocyte selection-associated high mobility group box protein TOX (sprot)

description: A thymocyte selection-associated high mobility group box protein TOX that is encoded in the genome of human.


name: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment

description: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell.


NK T cell lineage commitment

description: The process in which a pro-T cell becomes committed to becoming an NK T cell.


name: positive regulation of natural killer cell differentiation

description: Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation.


name: CD4-positive, alpha-beta T cell lineage commitment

description: The process in which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell.


name: CD8-positive, alpha-beta T cell lineage commitment

description: The process in which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell.


name: SUN1_HUMAN SUN domain-containing protein 1 (sprot)

description: A SUN domain-containing protein 1 that is encoded in the genome of human.


name: cytoskeleton-nuclear membrane anchor activity

description: The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane.


name: nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

description: The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration.


name: meiotic attachment of telomere to nuclear envelope

description: The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation.


name: nuclear matrix anchoring at nuclear membrane

description: The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane.


name: meiotic nuclear membrane microtubule tethering complex

description: A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis.


name: PLPHP_HUMAN Pyridoxal phosphate homeostasis protein (sprot)

description: A pyridoxal phosphate homeostasis protein PLPBP that is encoded in the genome of human.


ERLN2_HUMAN Erlin-2 (sprot)

An erlin-2 that is encoded in the genome of human.


name: PRP6_HUMAN Pre-mRNA-processing factor 6 (sprot)

description: A pre-mRNA-processing factor 6 that is encoded in the genome of human.


RNA localization

description: A process in which RNA is transported to, or maintained in, a specific location.


name: DKK1_HUMAN Dickkopf-related protein 1 (sprot)

description: A dickkopf-related protein 1 that is encoded in the genome of human.


receptor antagonist activity

description: The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor.


endoderm formation

description: The formation of the endoderm during gastrulation.


heart induction

description: The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart.


endocardial cushion development

description: The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.


name: negative regulation of mesodermal cell fate specification

description: Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification.


name: regulation of endodermal cell fate specification

description: Any process that mediates the specification of a cell into an endoderm cell.


name: positive regulation of Wnt signaling pathway, calcium modulating pathway

description: Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).


name: regulation of synaptic transmission, glutamatergic

description: Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.


name: Wnt signaling pathway involved in somitogenesis

description: The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis.


synapse pruning

description: A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.


name: regulation of dopaminergic neuron differentiation

description: Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation.


name: negative regulation of Wnt-Frizzled-LRP5/6 complex assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly.


name: positive regulation of midbrain dopaminergic neuron differentiation

description: Any process that activates or increases the frequency, rate or extent of midbrain dopaminergic neuron differentiation.


name: negative regulation of presynapse assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly.


name: positive regulation of Wnt signaling pathway, planar cell polarity pathway

description: Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway.


name: AGRL1_HUMAN Adhesion G protein-coupled receptor L1 (sprot)

description: An adhesion G protein-coupled receptor L1 that is encoded in the genome of human.


latrotoxin receptor activity

description: Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: ABCA8_HUMAN ABC-type organic anion transporter ABCA8 (sprot)

description: An ABC-type organic anion transporter ABCA8 that is encoded in the genome of human.


name: positive regulation of cholesterol efflux

description: Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.


name: PCF11_HUMAN Pre-mRNA cleavage complex 2 protein Pcf11 (sprot)

description: A pre-mRNA cleavage complex 2 protein Pcf11 that is encoded in the genome of human.


name: termination of RNA polymerase II transcription

description: A transcription termination process that completes the production of a primary RNA polymerase II transcript.


name: NFAT5_HUMAN Nuclear factor of activated T-cells 5 (sprot)

description: A nuclear factor of activated T-cells 5 that is encoded in the genome of human.


name: regulation of calcineurin-NFAT signaling cascade

description: Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade.


cellular hyperosmotic response

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.


name: positive regulation of leukocyte adhesion to vascular endothelial cell

description: Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell.


name: ENDD1_HUMAN Endonuclease domain-containing 1 protein (sprot)

description: An endonuclease domain-containing 1 protein that is encoded in the genome of human.


name: CDK14_HUMAN Cyclin-dependent kinase 14 (sprot)

description: A cyclin-dependent kinase 14 that is encoded in the genome of human.


name: cyclin-dependent protein kinase holoenzyme complex

description: Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.


name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex

description: Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm.


name: GLCE_HUMAN D-glucuronyl C5-epimerase (sprot)

description: A D-glucuronyl C5-epimerase that is encoded in the genome of human.


description: Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate.


heparin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.


name: GLSK_HUMAN Glutaminase kidney isoform, mitochondrial (sprot)

description: A glutaminase kidney isoform, mitochondrial that is encoded in the genome of human.


glutaminase activity

description: Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.


glutamate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.


glutamine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid.


name: HAUS5_HUMAN HAUS augmin-like complex subunit 5 (sprot)

description: A HAUS augmin-like complex subunit 5 that is encoded in the genome of human.


regulation of microtubule nucleation

description: Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.


HAUS complex

description: A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex.


mitotic spindle microtubule

description: Any microtubule that is part of a mitotic spindle; anchored at one spindle pole.


name: ABLM3_HUMAN Actin-binding LIM protein 3 (sprot)

description: An actin-binding LIM protein 3 that is encoded in the genome of human.


name: SLIK3_HUMAN SLIT and NTRK-like protein 3 (sprot)

description: A SLIT and NTRK-like protein 3 that is encoded in the genome of human.


terminal button organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.


name: neurotransmitter-gated ion channel clustering

description: The receptor clustering process in which neurotransmitter-gated ion channels are localized to distinct domains in the cell membrane.


name: gephyrin clustering involved in postsynaptic density assembly

description: The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses.


name: RNF37_HUMAN RING finger protein 37 (sprot)

description: A RING finger protein 37 that is encoded in the genome of human.


ubiquitin-ubiquitin ligase activity

description: Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.


name: FBX21_HUMAN F-box only protein 21 (sprot)

description: An F-box only protein 21 that is encoded in the genome of human.


name: KDM4B_HUMAN Lysine-specific demethylase 4B (sprot)

description: A lysine-specific demethylase 4B that is encoded in the genome of human.