description: Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + H2O = sn-1-lyso-2-16:0-monogalactosyldiacylglycerol + oleate + H+.


galactolipid catabolic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine.


name: OAZ1_HUMAN Ornithine decarboxylase antizyme 1 (sprot)

description: An ornithine decarboxylase antizyme that is encoded in the genome of human.


name: SYYC_HUMAN Tyrosine--tRNA ligase, cytoplasmic (sprot)

description: A tyrosine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


tyrosine-tRNA ligase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+.


tyrosyl-tRNA aminoacylation

description: The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


name: UBP14_HUMAN Ubiquitin carboxyl-terminal hydrolase 14 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 14 that is encoded in the genome of human.


name: AAKG1_HUMAN 5'-AMP-activated protein kinase subunit gamma-1 (sprot)

description: A 5'-AMP-activated protein kinase subunit gamma-1 that is encoded in the genome of human.


name: AAPK2_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-2 (sprot)

description: A 5'-AMP-activated protein kinase catalytic subunit alpha-2 that is encoded in the genome of human.


name: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity

description: Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP.


histone H2BS36 kinase activity

description: Catalysis of the reaction: histone H2B-serine (position 36) + ATP = histone H2B-phosphoserine (position 36) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 36 of histone H2B.


regulation of stress granule assembly

description: Any process that modulates the rate, frequency or extent of stress granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.


name: HSP72_HUMAN Heat shock-related 70 kDa protein 2 (sprot)

description: A heat shock-related 70 kDa protein 2 that is encoded in the genome of human.


name: BCAT1_HUMAN Branched-chain-amino-acid aminotransferase, cytosolic (sprot)

description: A branched-chain-amino-acid aminotransferase, cytosolic that is encoded in the genome of human.


name: AT12A_HUMAN Potassium-transporting ATPase alpha chain 2 (sprot)

description: A potassium-transporting ATPase alpha chain 2 that is encoded in the genome of human.


name: AT1B3_HUMAN Sodium/potassium-transporting ATPase subunit beta-3 (sprot)

description: A sodium/potassium-transporting ATPase subunit beta-3 that is encoded in the genome of human.


name: ATNG_HUMAN Sodium/potassium-transporting ATPase subunit gamma (sprot)

description: A sodium/potassium-transporting ATPase subunit gamma that is encoded in the genome of human.


name: RD23A_HUMAN UV excision repair protein RAD23 homolog A (sprot)

description: A UV excision repair protein RAD23 homolog A that is encoded in the genome of human.


name: RD23B_HUMAN UV excision repair protein RAD23 homolog B (sprot)

description: A UV excision repair protein RAD23 homolog B that is encoded in the genome of human.


DNA damage sensor activity

description: A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signaling response.


name: PDE1A_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (sprot)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A that is encoded in the genome of human.


name: calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity

description: Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin.


name: calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity

description: Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin.


name: regulation of smooth muscle cell apoptotic process

description: Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process.


name: EPHB3_HUMAN Ephrin type-B receptor 3 (sprot)

description: An ephrin type-B receptor 3 that is encoded in the genome of human.


name: EPHA5_HUMAN Ephrin type-A receptor 5 (sprot)

description: An ephrin type-A receptor 5 that is encoded in the genome of human.


name: EPHB4_HUMAN Ephrin type-B receptor 4 (sprot)

description: An ephrin type-B receptor 4 that is encoded in the genome of human.


name: EPHB1_HUMAN Ephrin type-B receptor 1 (sprot)

description: An ephrin type-B receptor 1 that is encoded in the genome of human.


name: EPHA4_HUMAN Ephrin type-A receptor 4 (sprot)

description: An ephrin type-A receptor 4 that is encoded in the genome of human.


DH domain binding

description: Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.


regulation of astrocyte differentiation

description: Any process that modulates the frequency, rate or extent of astrocyte differentiation.


neuron projection fasciculation

description: The collection of neuronal projections into a bundle of rods, known as a fascicle.


name: positive regulation of Rho guanyl-nucleotide exchange factor activity

description: Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.


name: DVLP1_HUMAN Putative segment polarity protein dishevelled homolog DVL1P1 (sprot)

description: A segment polarity protein dishevelled DVL-1-like that is encoded in the genome of human.


ARSF_HUMAN Arylsulfatase F (sprot)

An arylsulfatase F that is encoded in the genome of human.


An alpha-N-acetylglucosaminidase that is encoded in the genome of human.


alpha-N-acetylglucosaminidase activity

description: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides.


name: heparan sulfate proteoglycan metabolic process

description: The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.


response to disaccharide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus.


retinal rod cell development

description: Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light.


sequestering of iron ion

description: The process of binding or confining iron ions such that they are separated from other components of a biological system.


GALC_HUMAN Galactocerebrosidase (sprot)

A galactocerebrosidase that is encoded in the genome of human.


galactosylceramide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group.


name: KAD2_HUMAN Adenylate kinase 2, mitochondrial (sprot)

description: An adenylate kinase 2, mitochondrial that is encoded in the genome of human.


name: PRRX1_HUMAN Paired mesoderm homeobox protein 1 (sprot)

description: A paired mesoderm homeobox protein 1 that is encoded in the genome of human.


name: regulation of neuron projection regeneration

description: Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage.


name: GAS1_HUMAN Growth arrest-specific protein 1 (sprot)

description: A growth arrest-specific protein 1 that is encoded in the genome of human.


name: regulation of ER to Golgi vesicle-mediated transport

description: Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.


name: PTN5_HUMAN Tyrosine-protein phosphatase non-receptor type 5 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 5 that is encoded in the genome of human.


name: GYS2_HUMAN Glycogen [starch] synthase, liver (sprot)

description: A glycogen [starch] synthase, liver that is encoded in the genome of human.


name: NRL_HUMAN Neural retina-specific leucine zipper protein (sprot)

description: A neural retina-specific leucine zipper protein that is encoded in the genome of human.


name: EMP1_HUMAN Epithelial membrane protein 1 (sprot)

description: An epithelial membrane protein 1 that is encoded in the genome of human.


bleb assembly

description: The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.


name: EMP2_HUMAN Epithelial membrane protein 2 (sprot)

description: An epithelial membrane protein 2 that is encoded in the genome of human.


actin-mediated cell contraction

description: The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.


regulation of vasculogenesis

description: Any process that modulates the frequency, rate or extent of vasculogenesis.


name: EMP3_HUMAN Epithelial membrane protein 3 (sprot)

description: An epithelial membrane protein 3 that is encoded in the genome of human.


name: UDB15_HUMAN UDP-glucuronosyltransferase 2B15 (sprot)

description: A UDP-glucuronosyltransferase 2B15 that is encoded in the genome of human.


name: HMCS2_HUMAN Hydroxymethylglutaryl-CoA synthase, mitochondrial (sprot)

description: A hydroxymethylglutaryl-CoA synthase, mitochondrial that is encoded in the genome of human.


description: Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H+.


response to monosaccharide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus.


name: P5CS_HUMAN Delta-1-pyrroline-5-carboxylate synthase (sprot)

description: A delta-1-pyrroline-5-carboxylate synthase that is encoded in the genome of human.


glutamate 5-kinase activity

description: Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+.


description: Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH.


ornithine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.


name: SNAA_HUMAN Alpha-soluble NSF attachment protein (sprot)

description: An alpha-soluble NSF attachment protein that is encoded in the genome of human.


name: ADPRH_HUMAN ADP-ribosylhydrolase ARH1 (sprot)

description: An ADP-ribosylhydrolase ARH1 that is encoded in the genome of human.


ADP-ribosylarginine hydrolase activity

description: Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose.


name: SLUR1_HUMAN Secreted Ly-6/uPAR-related protein 1 (sprot)

description: A secreted Ly-6/uPAR-related protein 1 that is encoded in the genome of human.


name: acetylcholine receptor activator activity

description: Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased.


name: MFAP2_HUMAN Microfibrillar-associated protein 2 (sprot)

description: A microfibrillar-associated protein 2 that is encoded in the genome of human.


name: AIF1_HUMAN Allograft inflammatory factor 1 (sprot)

description: An allograft inflammatory factor 1 that is encoded in the genome of human.


parallel actin filament bundle assembly

description: Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity.


name: IF5_HUMAN Eukaryotic translation initiation factor 5 (sprot)

description: A eukaryotic translation initiation factor 5 that is encoded in the genome of human.


name: S12A2_HUMAN Solute carrier family 12 member 2 (sprot)

description: A solute carrier family 12 member 2 that is encoded in the genome of human.


name: positive regulation of aspartate secretion

description: Any process that activates or increases the frequency, rate or extent of aspartate secretion.


description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in).


name: chloride:monoatomic cation symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in).


name: metal ion transmembrane transporter activity

description: Enables the transfer of metal ions from one side of a membrane to the other.


positive regulation of cell volume

description: Any process that increases cell volume.


transepithelial ammonium transport

description: The directed movement of ammonium ions from one side of an epithelium to the other.


name: inorganic cation import across plasma membrane

description: The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol.


name: S12A3_HUMAN Solute carrier family 12 member 3 (sprot)

description: A solute carrier family 12 member 3 that is encoded in the genome of human.


name: PSMD4_HUMAN 26S proteasome non-ATPase regulatory subunit 4 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 4 that is encoded in the genome of human.


name: DRG2_HUMAN Developmentally-regulated GTP-binding protein 2 (sprot)

description: A developmentally-regulated GTP-binding protein 2 that is encoded in the genome of human.


name: GEM_HUMAN GTP-binding protein GEM (sprot)

description: A GTP-binding protein GEM that is encoded in the genome of human.


name: RAD_HUMAN GTP-binding protein RAD (sprot)

description: A GTP-binding protein RAD that is encoded in the genome of human.


name: NR1H2_HUMAN Oxysterols receptor LXR-beta (sprot)

description: An oxysterols receptor LXR-beta that is encoded in the genome of human.


negative regulation of pinocytosis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.


name: positive regulation of secretion of lysosomal enzymes

description: Any process that increases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell.


APOC4_HUMAN Apolipoprotein C-IV (sprot)

An apolipoprotein C-IV that is encoded in the genome of human.


name: PLTP_HUMAN Phospholipid transfer protein (sprot)

description: A phospholipid transfer protein that is encoded in the genome of human.


name: very-low-density lipoprotein particle binding

description: Binding to a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm.


phospholipid transfer activity

description: Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


diacylglyceride transfer activity

description: Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location.


phosphatidylglycerol transfer activity

description: Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location.


cerebroside transfer activity

description: Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location.


description: Removes phosphatidylethanolamine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


vitamin E biosynthetic process

description: The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.


glycolipid transport

description: The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


XPO2_HUMAN Exportin-2 (sprot)

An exportin-2 that is encoded in the genome of human.


BI1_HUMAN Bax inhibitor 1 (sprot)

A Bax inhibitor 1 that is encoded in the genome of human.


endoribonuclease inhibitor activity

description: Binds to and stops, prevents or reduces the activity of endoribonuclease.


name: neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.


name: negative regulation of endoribonuclease activity

description: Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.


AQP5_HUMAN Aquaporin-5 (sprot)

An aquaporin-5 that is encoded in the genome of human.


name: TERA_HUMAN Transitional endoplasmic reticulum ATPase (sprot)

description: A transitional endoplasmic reticulum ATPase that is encoded in the genome of human.


name: K48-linked polyubiquitin modification-dependent protein binding

description: Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein.


name: flavin adenine dinucleotide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes.


name: protein-DNA covalent cross-linking repair

description: The removal of covalent cross-link between DNA and a protein.


name: positive regulation of protein K63-linked deubiquitination

description: Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination.


name: positive regulation of Lys63-specific deubiquitinase activity

description: Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity.


cellular response to arsenite ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus.


name: regulation of protein localization to chromatin

description: Any process that modulates the frequency, rate or extent of protein localization to chromatin.


VCP-NSFL1C complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.


Derlin-1 retrotranslocation complex

description: A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel.


name: IOD3_HUMAN Thyroxine 5-deiodinase (sprot)

description: A thyroxine 5-deiodinase that is encoded in the genome of human.


thyroxine 5'-deiodinase activity

description: Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2.


thyroxine 5-deiodinase activity

description: Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.


thyroid hormone catabolic process

description: The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.


brown fat cell proliferation

description: The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species.


name: FGF8_HUMAN Fibroblast growth factor 8 (sprot)

description: A fibroblast growth factor 8 that is encoded in the genome of human.


neural plate morphogenesis

description: The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.


pallium development

description: The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon.


subpallium development

description: The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon.


midbrain-hindbrain boundary development

description: The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.


name: MFAP1_HUMAN Microfibrillar-associated protein 1 (sprot)

description: A microfibrillar-associated protein 1 that is encoded in the genome of human.


name: MFAP3_HUMAN Microfibril-associated glycoprotein 3 (sprot)

description: A microfibril-associated glycoprotein 3 that is encoded in the genome of human.


name: MFAP4_HUMAN Microfibril-associated glycoprotein 4 (sprot)

description: A microfibril-associated glycoprotein 4 that is encoded in the genome of human.


name: regulation of collagen metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.


name: ECHB_HUMAN Trifunctional enzyme subunit beta, mitochondrial (sprot)

description: A trifunctional enzyme subunit beta, mitochondrial that is encoded in the genome of human.


name: PAR2_HUMAN Proteinase-activated receptor 2 (sprot)

description: A proteinase-activated receptor 2 that is encoded in the genome of human.


name: positive regulation of eosinophil degranulation

description: Any process that activates or increases the frequency, rate or extent of eosinophil degranulation.


leukocyte proliferation

description: The expansion of a leukocyte population by cell division.


name: positive regulation of neutrophil mediated killing of gram-negative bacterium

description: Any process that increases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil.


name: potassium channel activating, G protein-coupled receptor signaling pathway

description: The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds activation of a potassium ion channel.


name: positive regulation of renin secretion into blood stream

description: Any process that activates or increases the frequency, rate or extent of renin secretion into blood stream.


name: regulation of chemokine (C-X-C motif) ligand 2 production

description: Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production.


AQP4_HUMAN Aquaporin-4 (sprot)

An aquaporin-4 that is encoded in the genome of human.


UCN1_HUMAN Urocortin (sprot)

A urocortin that is encoded in the genome of human.


name: INHBC_HUMAN Inhibin beta C chain (sprot)

description: An activin/inhibin beta C chain that is encoded in the genome of human.


name: GDF10_HUMAN Growth/differentiation factor 10 (sprot)

description: A bone morphogenetic protein 3B that is encoded in the genome of human.


name: MANF_HUMAN Mesencephalic astrocyte-derived neurotrophic factor (sprot)

description: A protein ARMET that is encoded in the genome of human.


name: vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure

description: The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system.


name: MTP_HUMAN Microsomal triglyceride transfer protein large subunit (sprot)

description: A microsomal triglyceride transfer protein large subunit that is encoded in the genome of human.


triglyceride transfer activity

description: Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location.


ceramide 1-phosphate transfer activity

description: Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


plasma lipoprotein particle assembly

description: The non-covalent aggregation and arrangement of proteins and lipids to form a plasma lipoprotein particle.


name: NCKPL_HUMAN Nck-associated protein 1-like (sprot)

description: A Nck-associated protein 1-like that is encoded in the genome of human.


TORC2 complex binding

description: Binding to a TORC2 complex.


name: positive regulation of CD8-positive, alpha-beta T cell differentiation

description: Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation.


positive regulation of TORC2 signaling

description: Any process that activates or increases the frequency, rate or extent of TORC2 signaling.


SCAR complex

description: A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.


AFAD_HUMAN Afadin (sprot)

An afadin that is encoded in the genome of human.


AF10_HUMAN Protein AF-10 (sprot)

A protein AF-10 that is encoded in the genome of human.


AF17_HUMAN Protein AF-17 (sprot)

A protein AF-17 that is encoded in the genome of human.


renal potassium excretion

description: The elimination of potassium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine.


name: ELL_HUMAN RNA polymerase II elongation factor ELL (sprot)

description: An RNA polymerase II elongation factor ELL that is encoded in the genome of human.


histone locus body

description: A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body.


BRPF1_HUMAN Peregrin (sprot)

A peregrin that is encoded in the genome of human.


name: NP1L1_HUMAN Nucleosome assembly protein 1-like 1 (sprot)

description: A nucleosome assembly protein 1-like 1 that is encoded in the genome of human.


histone chaperone activity

description: Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone).


CASP7_HUMAN Caspase-7 (sprot)

A caspase-7 that is encoded in the genome of human.


lymphocyte apoptotic process

description: Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.


CASP9_HUMAN Caspase-9 (sprot)

A caspase-9 that is encoded in the genome of human.


caspase complex

description: A protein complex that contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes.


CASP6_HUMAN Caspase-6 (sprot)

A caspase-6 that is encoded in the genome of human.


name: GP2_HUMAN Pancreatic secretory granule membrane major glycoprotein GP2 (sprot)

description: A pancreatic secretory granule membrane major glycoprotein GP2 that is encoded in the genome of human.


name: antigen transcytosis by M cells in mucosal-associated lymphoid tissue

description: The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT.


ADK_HUMAN Adenosine kinase (sprot)

An adenosine kinase that is encoded in the genome of human.


dATP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate).


name: DSRAD_HUMAN Double-stranded RNA-specific adenosine deaminase (sprot)

description: A double-stranded RNA-specific adenosine deaminase that is encoded in the genome of human.


base conversion or substitution editing

description: Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s).


name: double-stranded RNA adenosine deaminase activity

description: Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule.


name: somatic diversification of immune receptors via somatic mutation

description: The process in which immune receptor genes are diversified through somatic mutation.


adenosine to inosine editing

description: The conversion of an adenosine residue to inosine in an RNA molecule by deamination.


name: negative regulation of post-transcriptional gene silencing by regulatory ncRNA

description: Any process that stops, prevents or reduces the frequency, rate or extent of post-transcriptional gene silencing by RNA.


name: LAMB2_HUMAN Laminin subunit beta-2 (sprot)

description: A laminin subunit beta-2 that is encoded in the genome of human.


name: structural constituent of synapse-associated extracellular matrix

description: The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft.


axon extension involved in regeneration

description: Long distance growth of a single axon process involved in regeneration of the neuron.


metanephric podocyte development

description: The process whose specific outcome is the progression of a metanephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros.


name: metanephric glomerular basement membrane development

description: The process whose specific outcome is the progression of the metanephric glomerular basement membrane over time, from its formation to the mature structure. The metanephric glomerular basement membrane is the basal laminal portion of the metanephric glomerulus which performs the actual filtration.


name: CDN2D_HUMAN Cyclin-dependent kinase 4 inhibitor D (sprot)

description: A cyclin-dependent kinase 4 inhibitor D that is encoded in the genome of human.


CADH4_HUMAN Cadherin-4 (sprot)

A cadherin-4 that is encoded in the genome of human.


CADH6_HUMAN Cadherin-6 (sprot)

A cadherin-6 that is encoded in the genome of human.


CADH8_HUMAN Cadherin-8 (sprot)

A cadherin-8 that is encoded in the genome of human.


CAD11_HUMAN Cadherin-11 (sprot)

A cadherin-11 that is encoded in the genome of human.


aortic valve formation

description: The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.


CAD12_HUMAN Cadherin-12 (sprot)

A cadherin-12 that is encoded in the genome of human.


CAD13_HUMAN Cadherin-13 (sprot)

A cadherin-13 that is encoded in the genome of human.


adiponectin binding

description: Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism.


localization within membrane

description: Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane.


CAD15_HUMAN Cadherin-15 (sprot)

A cadherin-15 that is encoded in the genome of human.


name: FOXG1_HUMAN Forkhead box protein G1 (sprot)

description: A forkhead box protein G1 that is encoded in the genome of human.


name: pyramidal neuron migration to cerebral cortex

description: The migration of a pyramidal neuron precursor from the ventricular zone to the correct layer of the cerebral cortex.


name: FOXA1_HUMAN Hepatocyte nuclear factor 3-alpha (sprot)

description: A hepatocyte nuclear factor 3-alpha that is encoded in the genome of human.


name: epithelial cell maturation involved in prostate gland development

description: The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.


respiratory basal cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a respiratory basal cell.


name: positive regulation of dopaminergic neuron differentiation

description: Any process that activates or increases the frequency, rate or extent of dopaminergic neuron differentiation.


name: FOXA3_HUMAN Hepatocyte nuclear factor 3-gamma (sprot)

description: A hepatocyte nuclear factor 3-gamma that is encoded in the genome of human.


TPD52_HUMAN Tumor protein D52 (sprot)

A tumor protein D52 that is encoded in the genome of human.


name: LMIP_HUMAN Lens fiber membrane intrinsic protein (sprot)

description: A lens fiber membrane intrinsic protein that is encoded in the genome of human.


name: ANM2_HUMAN Protein arginine N-methyltransferase 2 (sprot)

description: A protein arginine N-methyltransferase 2 that is encoded in the genome of human.


nuclear progesterone receptor binding

description: Binding to a nuclear progesterone receptor.


histone H3R8 methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to the arginine residue at position 8 of histone H3.


name: PKNX1_HUMAN Homeobox protein PKNOX1 (sprot)

description: A homeobox protein PKNOX1 that is encoded in the genome of human.


name: SEC13_HUMAN Protein SEC13 homolog (sprot)

description: A protein SEC13 that is encoded in the genome of human.


NH2L1_HUMAN NHP2-like protein 1 (sprot)

An NHP2-like protein 1 that is encoded in the genome of human.


U4 snRNA binding

description: Binding to a U4 small nuclear RNA (U4 snRNA).


U4atac snRNA binding

description: Binding to a U4atac small nuclear RNA (U4atac snRNA).


box C/D sno(s)RNA binding

description: Binding to a box C/D small nucleolar RNA.


box C/D snoRNP assembly

description: The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex.


dense fibrillar component

description: A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.


U4atac snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U4atac, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4atac snRNP, most of which remain associated with the U4atac snRNA both while the U4atac snRNP is free or assembled into the U4atac/U6atac complex or into a series of spliceosomal complexes.


name: PAX9_HUMAN Paired box protein Pax-9 (sprot)

description: A paired box protein Pax-9 that is encoded in the genome of human.


name: CCL23_HUMAN C-C motif chemokine 23 (sprot)

description: A C-C motif chemokine 23 that is encoded in the genome of human.


name: CCL18_HUMAN C-C motif chemokine 18 (sprot)

description: A C-C motif chemokine 18 that is encoded in the genome of human.


name: PSA_HUMAN Puromycin-sensitive aminopeptidase (sprot)

description: A puromycin-sensitive aminopeptidase that is encoded in the genome of human.


name: ALR_HUMAN FAD-linked sulfhydryl oxidase ALR (sprot)

description: An FAD-linked sulfhydryl oxidase ALR that is encoded in the genome of human.


name: HNRH2_HUMAN Heterogeneous nuclear ribonucleoprotein H2 (sprot)

description: A heterogeneous nuclear ribonucleoprotein H2 that is encoded in the genome of human.


XG_HUMAN Glycoprotein Xg (sprot)

A glycoprotein Xg that is encoded in the genome of human.


name: SCOT1_HUMAN Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (sprot)

description: A succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial that is encoded in the genome of human.


description: Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA.


ketone catabolic process

description: The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.


cellular ketone body metabolic process

description: The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism.


name: SH3BG_HUMAN SH3 domain-binding glutamic acid-rich protein (sprot)

description: An SH3 domain-binding glutamic acid-rich protein that is encoded in the genome of human.


name: UCP2_HUMAN Dicarboxylate carrier SLC25A8 (sprot)

description: A dicarboxylate carrier SLC25A8 that is encoded in the genome of human.


name: oxaloacetate transmembrane transporter activity

description: Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other.


name: malate transmembrane transporter activity

description: Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.


phosphate ion uniporter activity

description: Catalysis of the active transport of a phosphate ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


C4-dicarboxylate transport

description: The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms.


malate transmembrane transport

description: A process in which a malate ion is transported across a membrane.


description: The directed movement of oxaloacetate(2-) across a membrane.


name: SUMO3_HUMAN Small ubiquitin-related modifier 3 (sprot)

description: A small ubiquitin-related modifier 3 that is encoded in the genome of human.


name: EIF3B_HUMAN Eukaryotic translation initiation factor 3 subunit B (sprot)

description: A eukaryotic translation initiation factor 3 subunit B that is encoded in the genome of human.


name: RAG2_HUMAN V(D)J recombination-activating protein 2 (sprot)

description: A V(D)J recombination-activating protein 2 that is encoded in the genome of human.


B cell homeostatic proliferation

description: The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus.


name: FCGRN_HUMAN IgG receptor FcRn large subunit p51 (sprot)

description: An IgG receptor FcRn large subunit p51 that is encoded in the genome of human.


name: IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor

description: The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals.


name: UCP3_HUMAN Putative mitochondrial transporter UCP3 (sprot)

description: A putative mitochondrial transporter UCP3 that is encoded in the genome of human.


name: BID_HUMAN BH3-interacting domain death agonist (sprot)

description: A BH3-interacting domain death agonist that is encoded in the genome of human.


name: ATPK_HUMAN ATP synthase subunit f, mitochondrial (sprot)

description: An ATP synthase subunit f, mitochondrial that is encoded in the genome of human.


name: GFRA1_HUMAN GDNF family receptor alpha-1 (sprot)

description: A GDNF family receptor alpha-1 that is encoded in the genome of human.


neurotrophin receptor activity

description: Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity.


neurotrophin signaling pathway

description: The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.


name: DLX1_HUMAN Homeobox protein DLX-1 (sprot)

description: A homeobox protein DLX-1 that is encoded in the genome of human.


name: cerebral cortex GABAergic interneuron fate commitment

description: The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex.


name: positive regulation of amacrine cell differentiation

description: Any process that activates or increases the frequency, rate or extent of amacrine cell differentiation.


name: DLX5_HUMAN Homeobox protein DLX-5 (sprot)

description: A homeobox protein DLX-5 that is encoded in the genome of human.


interneuron axon guidance

description: The process in which the migration of an axon growth cone of an interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. An interneuron is any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region, as contrasted with projection neurons which have axons projecting to other brain regions.


name: DLX6_HUMAN Homeobox protein DLX-6 (sprot)

description: A homeobox protein DLX-6 that is encoded in the genome of human.


name: TPTE_HUMAN Putative tyrosine-protein phosphatase TPTE (sprot)

description: A putative tyrosine-protein phosphatase TPTE that is encoded in the genome of human.


name: NDUV3_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (sprot)

description: An NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial that is encoded in the genome of human.


name: RRP1_HUMAN Ribosomal RNA processing protein 1 homolog A (sprot)

description: A ribosomal RNA processing protein 1 homolog A that is encoded in the genome of human.


name: SYMC_HUMAN Methionine--tRNA ligase, cytoplasmic (sprot)

description: A methionine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


methionine-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).


methionyl-tRNA aminoacylation

description: The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


ITA1_HUMAN Integrin alpha-1 (sprot)

An integrin alpha-1 that is encoded in the genome of human.


CATW_HUMAN Cathepsin W (sprot)

A cathepsin W that is encoded in the genome of human.


name: ARP19_HUMAN cAMP-regulated phosphoprotein 19 (sprot)

description: A cAMP-regulated phosphoprotein 19 that is encoded in the genome of human.


name: MAZ_HUMAN Myc-associated zinc finger protein (sprot)

description: A Myc-associated zinc finger protein that is encoded in the genome of human.


name: CMC4_HUMAN Cx9C motif-containing protein 4 (sprot)

description: A Cx9C motif-containing protein 4 that is encoded in the genome of human.


MTCP1_HUMAN Protein p13 MTCP-1 (sprot)

A protein p13 MTCP-1 that is encoded in the genome of human.


name: TCL1A_HUMAN T-cell leukemia/lymphoma protein 1A (sprot)

description: A T-cell leukemia/lymphoma protein 1A that is encoded in the genome of human.


name: DPOE2_HUMAN DNA polymerase epsilon subunit 2 (sprot)

description: A DNA polymerase epsilon subunit 2 that is encoded in the genome of human.


epsilon DNA polymerase complex

description: A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.


P2RX3_HUMAN P2X purinoceptor 3 (sprot)

A P2X purinoceptor 3 that is encoded in the genome of human.


name: AP1S2_HUMAN AP-1 complex subunit sigma-2 (sprot)

description: An AP-1 complex subunit sigma-2 that is encoded in the genome of human.


name: ATP68_HUMAN ATP synthase subunit ATP5MJ, mitochondrial (sprot)

description: An ATP synthase subunit ATP5MJ, mitochondrial that is encoded in the genome of human.


name: ATP5E_HUMAN ATP synthase subunit epsilon, mitochondrial (sprot)

description: An ATP synthase subunit epsilon, mitochondrial that is encoded in the genome of human.


name: ATP5I_HUMAN ATP synthase subunit e, mitochondrial (sprot)

description: An ATP synthase subunit e, mitochondrial that is encoded in the genome of human.


LEG4_HUMAN Galectin-4 (sprot)

A galectin-4 that is encoded in the genome of human.


name: HDAC4_HUMAN Histone deacetylase 4 (sprot)

description: A histone deacetylase 4 that is encoded in the genome of human.


peptidyl-lysine deacetylation

description: The removal of an acetyl group from an acetylated lysine residue in a peptide or protein.


name: IF6_HUMAN Eukaryotic translation initiation factor 6 (sprot)

description: A eukaryotic translation initiation factor 6 that is encoded in the genome of human.


CAV3_HUMAN Caveolin-3 (sprot)

A caveolin-3 that is encoded in the genome of human.


name: regulation of signal transduction by receptor internalization

description: Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway.


name: regulation of nerve growth factor receptor activity

description: Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor.


name: negative regulation of sarcomere organization

description: Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


name: cellular response to organonitrogen compound

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.


name: regulation of membrane depolarization during cardiac muscle cell action potential

description: Any process that modulates the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential.


name: negative regulation of membrane depolarization during cardiac muscle cell action potential

description: Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential.


name: regulation of calcium ion transmembrane transporter activity

description: Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity.


name: positive regulation of caveolin-mediated endocytosis

description: Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis.


name: CTBP2_HUMAN C-terminal-binding protein 2 (sprot)

description: A C-terminal-binding protein 2 that is encoded in the genome of human.


name: DSCR4_HUMAN Down syndrome critical region protein 4 (sprot)

description: A Down syndrome critical region protein 4 that is encoded in the genome of human.


name: NDUA6_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 that is encoded in the genome of human.


name: TM50B_HUMAN Transmembrane protein 50B (sprot)

description: A transmembrane protein 50B that is encoded in the genome of human.


name: ARL4C_HUMAN ADP-ribosylation factor-like protein 4C (sprot)

description: An ADP-ribosylation factor-like protein 4C that is encoded in the genome of human.


name: PEX3_HUMAN Peroxisomal biogenesis factor 3 (sprot)

description: A peroxisomal biogenesis factor 3 that is encoded in the genome of human.


name: NDK5_HUMAN Nucleoside diphosphate kinase homolog 5 (sprot)

description: A nucleoside diphosphate kinase homolog 5 that is encoded in the genome of human.


radial spoke

description: Protein complex that links the outer microtubule doublet of a 9+2 type ciliary or flagellar axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules.


name: PER3_HUMAN Period circadian protein homolog 3 (sprot)

description: A period circadian protein homolog 3 that is encoded in the genome of human.


name: SOX10_HUMAN Transcription factor SOX-10 (sprot)

description: A transcription factor SOX-10 that is encoded in the genome of human.


positive regulation of gliogenesis

description: Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia.


name: KCNQ4_HUMAN Potassium voltage-gated channel subfamily KQT member 4 (sprot)

description: A voltage-gated potassium channel subunit KCNQ4 that is encoded in the genome of human.


WNT3_HUMAN Proto-oncogene Wnt-3 (sprot)

A proto-oncogene Wnt-3 that is encoded in the genome of human.


name: positive regulation of collateral sprouting in absence of injury

description: Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury.


name: Spemann organizer formation at the anterior end of the primitive streak

description: Formation of the specialized region at the anterior end of the primitive streak of the embryo that acts as the main signaling center establishing the body plan.


WNT3A_HUMAN Protein Wnt-3a (sprot)

A protein Wnt-3a that is encoded in the genome of human.


name: Wnt signaling pathway involved in forebrain neuroblast division

description: The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain.


name: positive regulation of mesodermal cell fate specification

description: Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification.


name: paraxial mesodermal cell fate commitment

description: The process in which a cell becomes committed to become a paraxial mesoderm cell.


name: axis elongation involved in somitogenesis

description: The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis.


name: calcium ion transmembrane transport via low voltage-gated calcium channel

description: A process in which a calcium ion is transported from one side of a membrane to the other by means of a low voltage-gated calcium channel.


WNT4_HUMAN Protein Wnt-4 (sprot)

A protein Wnt-4 that is encoded in the genome of human.


female sex determination

description: The specification of female sex of an individual organism.


name: negative regulation of testicular blood vessel morphogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis in the testicle.


metanephric nephron morphogenesis

description: The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros.


name: negative regulation of male gonad development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of male gonad development.


name: positive regulation of cortisol biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of cortisol biosynthetic process.


name: negative regulation of androgen biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of androgen biosynthetic process.


name: negative regulation of testosterone biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process.


WNT7B_HUMAN Protein Wnt-7b (sprot)

A protein Wnt-7b that is encoded in the genome of human.


name: establishment or maintenance of polarity of embryonic epithelium

description: Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo.


regulation of cell projection size

description: A process that modulates the size of a cell projection.


name: chemoattraction of dopaminergic neuron axon

description: The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal.


lobar bronchus development

description: The biological process whose specific outcome is the progression of a lobar bronchus from an initial condition to its mature state. This process begins with the formation of the lobar bronchus and ends with the mature structure. The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi.


name: developmental growth involved in morphogenesis

description: The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape.


name: outer medullary collecting duct development

description: The process whose specific outcome is the progression of the outer medullary collecting duct over time, from its formation to the mature structure. The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla.


name: inner medullary collecting duct development

description: The process whose specific outcome is the progression of the inner medullary collecting duct over time, from its formation to the mature structure. The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla.


name: RP1_HUMAN Oxygen-regulated protein 1 (sprot)

description: An oxygen-regulated protein 1 that is encoded in the genome of human.


NETR_HUMAN Neurotrypsin (sprot)

A neurotrypsin that is encoded in the genome of human.


CLD15_HUMAN Claudin-15 (sprot)

A claudin-15 that is encoded in the genome of human.


CLD6_HUMAN Claudin-6 (sprot)

A claudin-6 that is encoded in the genome of human.


CLD8_HUMAN Claudin-8 (sprot)

A claudin-8 that is encoded in the genome of human.


CLD12_HUMAN Claudin-12 (sprot)

A claudin-12 that is encoded in the genome of human.


CLD17_HUMAN Claudin-17 (sprot)

A claudin-17 that is encoded in the genome of human.


BACE1_HUMAN Beta-secretase 1 (sprot)

A beta-secretase 1 that is encoded in the genome of human.


beta-aspartyl-peptidase activity

description: Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide.


Golgi-associated vesicle lumen

description: The volume enclosed by the membrane of a Golgi-associated vesicle.


name: EP3B_HUMAN Epididymal secretory protein E3-beta (sprot)

description: An epididymal secretory protein E3-beta that is encoded in the genome of human.


CLD18_HUMAN Claudin-18 (sprot)

A claudin-18 that is encoded in the genome of human.


tight junction organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.


CLD20_HUMAN Claudin-20 (sprot)

A claudin-20 that is encoded in the genome of human.


name: GSC_HUMAN Homeobox protein goosecoid (sprot)

description: A homeobox protein goosecoid that is encoded in the genome of human.


name: DHB7_HUMAN 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (sprot)

description: A 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 that is encoded in the genome of human.


name: BCAR1_HUMAN Breast cancer anti-estrogen resistance protein 1 (sprot)

description: A breast cancer anti-estrogen resistance protein 1 that is encoded in the genome of human.


STX17_HUMAN Syntaxin-17 (sprot)

A syntaxin-17 that is encoded in the genome of human.


name: endoplasmic reticulum-Golgi intermediate compartment organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment.


name: NRG3_HUMAN Pro-neuregulin-3, membrane-bound isoform (sprot)

description: A pro-neuregulin-3, membrane-bound isoform that is encoded in the genome of human.


name: chemorepulsion involved in interneuron migration from the subpallium to the cortex

description: The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex.


ERBB4 signaling pathway

description: The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: RBM11_HUMAN Splicing regulator RBM11 (sprot)

description: A splicing regulator RBM11 that is encoded in the genome of human.


name: H2BFS_HUMAN Histone H2B type F-S (sprot)

description: A histone H2B type F-S that is encoded in the genome of human.


name: PIGP_HUMAN Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (sprot)

description: A phosphatidylinositol N-acetylglucosaminyltransferase subunit P that is encoded in the genome of human.


DSCR6_HUMAN Protein ripply3 (sprot)

A protein ripply3 that is encoded in the genome of human.


name: G6PT2_HUMAN Glucose-6-phosphate exchanger SLC37A1 (sprot)

description: A glucose-6-phosphate exchanger SLC37A1 that is encoded in the genome of human.


name: HUNK_HUMAN Hormonally up-regulated neu tumor-associated kinase (sprot)

description: A hormonally up-regulated neu tumor-associated kinase that is encoded in the genome of human.


name: SIK1_HUMAN Serine/threonine-protein kinase SIK1 (sprot)

description: A serine/threonine-protein kinase SIK1 that is encoded in the genome of human.


regulation of myotube differentiation

description: Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


name: negative regulation of triglyceride biosynthetic process

description: Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.


name: negative regulation of CREB transcription factor activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB.


name: RWD2B_HUMAN RWD domain-containing protein 2B (sprot)

description: An RWD domain-containing protein 2B that is encoded in the genome of human.


name: PRD15_HUMAN PR domain zinc finger protein 15 (sprot)

description: A PR domain zinc finger protein 15 that is encoded in the genome of human.


name: SOX8_HUMAN Transcription factor SOX-8 (sprot)

description: A transcription factor SOX-8 that is encoded in the genome of human.


name: UBS3A_HUMAN Ubiquitin-associated and SH3 domain-containing protein A (sprot)

description: A ubiquitin-associated and SH3 domain-containing protein A that is encoded in the genome of human.


name: CF298_HUMAN Cilia- and flagella-associated protein 298 (sprot)

description: A protein that is a translation product of the CFAP298 gene in human.


regulation of cilium movement

description: Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.


name: M3KCL_HUMAN MAP3K7 C-terminal-like protein (sprot)

description: A MAP3K7 C-terminal-like protein that is encoded in the genome of human.


name: RIPK4_HUMAN Receptor-interacting serine/threonine-protein kinase 4 (sprot)

description: A receptor-interacting serine/threonine-protein kinase 4 that is encoded in the genome of human.


name: WDR4_HUMAN tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (sprot)

description: A tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 that is encoded in the genome of human.


name: tRNA methyltransferase activator activity

description: Binds to and increases the activity of a methyltransferase.


tRNA (guanine-N7)-methylation

description: The process whereby a guanine in a tRNA is methylated at the N7 position of guanine.


tRNA methyltransferase complex

description: A multimeric protein complex involved in the methylation of specific nucleotides in tRNA.


tRNA (m7G46) methyltransferase complex

description: A protein complex involved in the catalysis of the formation of the modified nucleotide 7-methylguanine (at position 46 in certain tRNAs, such as tRNA(phe) and tRNA(met). In yeast, it is a heterotetramer of two subunits, Trm8 (catalytic) and Trm82 (WD repeat).


name: TBX4_HUMAN T-box transcription factor TBX4 (sprot)

description: A T-box transcription factor TBX4 that is encoded in the genome of human.


name: SCND1_HUMAN SCAN domain-containing protein 1 (sprot)

description: A SCAN domain-containing protein 1 that is encoded in the genome of human.


name: JAM2_HUMAN Junctional adhesion molecule B (sprot)

description: A junctional adhesion molecule B that is encoded in the genome of human.


name: hematopoietic stem cell migration to bone marrow

description: The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.


name: positive regulation of lymphocyte migration

description: Any process that activates or increases the frequency, rate or extent of lymphocyte migration.


name: TMM33_HUMAN Transmembrane protein 33 (sprot)

description: A transmembrane protein 33 that is encoded in the genome of human.


name: regulation of endoplasmic reticulum tubular network organization

description: Any process that modulates the frequency, rate or extent of endoplasmic reticulum tubular network organization.


name: NAC3_HUMAN Sodium/calcium exchanger 3 (sprot)

description: A sodium/calcium exchanger 3 that is encoded in the genome of human.


name: monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential

description: Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.


name: SYJ2B_HUMAN Synaptojanin-2-binding protein (sprot)

description: A synaptojanin-2-binding protein that is encoded in the genome of human.


name: GEMI4_HUMAN Gem-associated protein 4 (sprot)

description: A gem-associated protein 4 that is encoded in the genome of human.


name: EVC_HUMAN EvC complex member EVC (sprot)

description: An EvC complex member EVC that is encoded in the genome of human.


name: KLF3_HUMAN Krueppel-like factor 3 (sprot)

description: A krueppel-like factor 3 that is encoded in the genome of human.


name: PCBP3_HUMAN Poly(rC)-binding protein 3 (sprot)

description: A poly(rC)-binding protein 3 that is encoded in the genome of human.


C-rich single-stranded DNA binding

description: Binding to C-rich, single-stranded DNA.


name: PCBP4_HUMAN Poly(rC)-binding protein 4 (sprot)

description: A poly(rC)-binding protein 4 that is encoded in the genome of human.


name: TMPS3_HUMAN Transmembrane protease serine 3 (sprot)

description: A transmembrane protease serine 3 that is encoded in the genome of human.


name: RAB38_HUMAN Ras-related protein Rab-38 (sprot)

description: A Ras-related protein Rab-38 that is encoded in the genome of human.


AP-1 adaptor complex binding

description: Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).


AP-3 adaptor complex binding

description: Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).


BLOC-2 complex binding

description: Binding to a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules.


name: CAR18_HUMAN Caspase recruitment domain-containing protein 18 (sprot)

description: A caspase recruitment domain-containing protein 18 that is encoded in the genome of human.


name: RAB25_HUMAN Ras-related protein Rab-25 (sprot)

description: A Ras-related protein Rab-25 that is encoded in the genome of human.


pseudopodium organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement.


pseudopodium membrane

description: The portion of the plasma membrane surrounding a pseudopodium.


CORO7_HUMAN Coronin-7 (sprot)

A coronin-7 that is encoded in the genome of human.


name: TCTA_HUMAN T-cell leukemia translocation-altered gene protein (sprot)

description: A T-cell leukemia translocation-altered gene protein that is encoded in the genome of human.


osteoclast fusion

description: The plasma membrane fusion process that results in fusion of mononuclear osteoclasts to form a multinuclear osteoclast.


CLD2_HUMAN Claudin-2 (sprot)

A claudin-2 that is encoded in the genome of human.


name: NU107_HUMAN Nuclear pore complex protein Nup107 (sprot)

description: A nuclear pore complex protein Nup107 that is encoded in the genome of human.


GSDMD_HUMAN Gasdermin-D (sprot)

A gasdermin-D that is encoded in the genome of human.


SNX16_HUMAN Sorting nexin-16 (sprot)

A sorting nexin-16 that is encoded in the genome of human.


name: RGS8_HUMAN Regulator of G-protein signaling 8 (sprot)

description: A regulator of G-protein signaling 8 that is encoded in the genome of human.


name: regulation of dopamine receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.


name: SELB_HUMAN Selenocysteine-specific elongation factor (sprot)

description: A selenocysteine-specific elongation factor that is encoded in the genome of human.


name: CXA9_HUMAN Gap junction alpha-9 protein (sprot)

description: A gap junction alpha-9 protein that is encoded in the genome of human.


name: FBXW4_HUMAN F-box/WD repeat-containing protein 4 (sprot)

description: An F-box/WD repeat-containing protein 4 that is encoded in the genome of human.


name: KCNKA_HUMAN Potassium channel subfamily K member 10 (sprot)

description: A potassium channel subfamily K member 10 that is encoded in the genome of human.


name: CABP4_HUMAN Calcium-binding protein 4 (sprot)

description: A calcium-binding protein 4 that is encoded in the genome of human.


photoreceptor cell morphogenesis

description: The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.


SESN2_HUMAN Sestrin-2 (sprot)

A sestrin-2 that is encoded in the genome of human.


sulfiredoxin activity

description: Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.


name: regulation of response to reactive oxygen species

description: Any process that modulates the frequency, rate or extent of response to reactive oxygen species.


name: negative regulation of translation in response to endoplasmic reticulum stress

description: Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.


SESN3_HUMAN Sestrin-3 (sprot)

A sestrin-3 that is encoded in the genome of human.


TORC2 signaling

description: A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.


name: FOXL2_HUMAN Forkhead box protein L2 (sprot)

description: A forkhead box protein L2 that is encoded in the genome of human.


name: cysteine-type endopeptidase regulator activity involved in apoptotic process

description: Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process.


female somatic sex determination

description: The determination of sex and sexual phenotypes in a female organism's soma.


granulosa cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals.


name: ISK7_HUMAN Serine protease inhibitor Kazal-type 7 (sprot)

description: A serine protease inhibitor Kazal-type 7 that is encoded in the genome of human.


EPIPL_HUMAN Epiplakin (sprot)

An epiplakin that is encoded in the genome of human.


name: negative regulation of keratinocyte migration

description: Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte migration.


regulation of epithelium regeneration

description: Any process that modulates the frequency, rate or extent of epithelium regeneration.


perinucleolar compartment

description: The perinucleolar compartment (PNC) is a subnuclear structure associated with, but structurally distinct from, the nucleolus. The PNC contains large amounts of the heterogeneous nuclear ribonucleoprotein complex (hnRNP) called hnRNP 1 (PTB). Many RNA binding proteins as well as RNA polymerase III transcripts are highly enriched in this compartment. PTB and pol III transcripts are required for the integrity of the PNC.


name: INHBE_HUMAN Inhibin beta E chain (sprot)

description: An activin/inhibin beta E chain that is encoded in the genome of human.


name: OR1D5_HUMAN Olfactory receptor 1D5 (sprot)

description: An olfactory receptor 1D5 that is encoded in the genome of human.


name: OR2B6_HUMAN Olfactory receptor 2B6 (sprot)

description: An olfactory receptor 2B6 that is encoded in the genome of human.


name: OR4D2_HUMAN Olfactory receptor 4D2 (sprot)

description: An olfactory receptor 4D2 that is encoded in the genome of human.


name: O10A3_HUMAN Olfactory receptor 10A3 (sprot)

description: An olfactory receptor 10A3 that is encoded in the genome of human.


name: O12D2_HUMAN Olfactory receptor 12D2 (sprot)

description: An olfactory receptor 12D2 that is encoded in the genome of human.


name: LOXL3_HUMAN Lysyl oxidase homolog 3 (sprot)

description: A lysyl oxidase homolog 3 that is encoded in the genome of human.


fibronectin fibril organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a fibronectin fibril.


name: negative regulation of T-helper 17 cell lineage commitment

description: Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell lineage commitment.


PROK1_HUMAN Prokineticin-1 (sprot)

A prokineticin-1 that is encoded in the genome of human.


vascular endothelial cell proliferation

description: The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population.


name: VSX2_HUMAN Visual system homeobox 2 (sprot)

description: A visual system homeobox 2 that is encoded in the genome of human.


name: ZN121_HUMAN Zinc finger protein 121 (sprot)

description: A zinc finger protein 121 that is encoded in the genome of human.


name: ANTR2_HUMAN Anthrax toxin receptor 2 (sprot)

description: An anthrax toxin receptor 2 that is encoded in the genome of human.


name: MLF1_HUMAN Myeloid leukemia factor 1 (sprot)

description: A myeloid leukemia factor 1 that is encoded in the genome of human.


name: ATS12_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 12 (sprot)

description: An a disintegrin and metalloproteinase with thrombospondin motifs 12 that is encoded in the genome of human.


proteoglycan catabolic process

description: The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


name: negative regulation of hepatocyte growth factor receptor signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway.


name: negative regulation of cellular response to hepatocyte growth factor stimulus

description: Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus.


NRX1B_HUMAN Neurexin-1-beta (sprot)

A neurexin-1-beta that is encoded in the genome of human.


neuroligin family protein binding

description: Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation.


neuronal signal transduction

description: The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular.


name: protein-containing complex assembly involved in synapse maturation

description: The aggregation, arrangement and bonding together of a set of components to form a protein complex that contributes to synapse maturation.


name: guanylate kinase-associated protein clustering

description: The clustering process in which guanylate kinase-associated proteins (GKAPs) are localized to distinct domains in the cell membrane. GKAP facilitates assembly of the post synaptic density of neurons.


name: postsynaptic density protein 95 clustering

description: The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins.


receptor localization to synapse

description: Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.


name: positive regulation of presynaptic active zone assembly

description: Any process that activates or increases the frequency, rate or extent of presynaptic active zone assembly.


NRX2B_HUMAN Neurexin-2-beta (sprot)

A neurexin-2-beta that is encoded in the genome of human.


NXPH1_HUMAN Neurexophilin-1 (sprot)

A neurexophilin-1 that is encoded in the genome of human.


CLRN1_HUMAN Clarin-1 (sprot)

A clarin-1 that is encoded in the genome of human.


equilibrioception

description: The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion.


FAM3B_HUMAN Protein FAM3B (sprot)

A protein FAM3B that is encoded in the genome of human.


name: SIM11_HUMAN Small integral membrane protein 11 (sprot)

description: A small integral membrane protein 11 that is encoded in the genome of human.


name: CU067_HUMAN Uncharacterized protein encoded by LINC01547 (sprot)

description: A protein that is a translation product of the LINC01547 gene in human.


MTPN_HUMAN Myotrophin (sprot)

A myotrophin that is encoded in the genome of human.


name: positive regulation of macromolecule biosynthetic process

description: Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.


name: regulation of barbed-end actin filament capping

description: Any process that modulates the frequency, rate or extent of barbed-end actin filament capping.


name: FXYD7_HUMAN FXYD domain-containing ion transport regulator 7 (sprot)

description: An FXYD domain-containing ion transport regulator 7 that is encoded in the genome of human.


regulation of monoatomic ion transport

description: Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: FXYD8_HUMAN Putative FXYD domain-containing ion transport regulator 8 (sprot)


name: YBEY_HUMAN Endoribonuclease YbeY (sprot)

description: An rRNA maturation factor homolog that is encoded in the genome of human.


name: EVA1C_HUMAN Protein eva-1 homolog C (sprot)

description: A protein FAM176C that is encoded in the genome of human.


S26A5_HUMAN Prestin (sprot)

A prestin that is encoded in the genome of human.


response to salicylic acid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus.


lateral wall of outer hair cell

description: The lateral wall of an outer hair cell (OHC) is a unique trilaminate composite consisting of the plasma membrane, an underlying cytoskeletal network containing an actin-spectrin cortical lattice, and an adjacent system of circumferential lamellar organelles known as the subsurface cisternae.


name: TIRAP_HUMAN Toll/interleukin-1 receptor domain-containing adapter protein (sprot)

description: A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of human.


Toll-like receptor 2 binding

description: Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response.


name: positive regulation of interleukin-15 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-15 production.


name: TIRAP-dependent toll-like receptor 4 signaling pathway

description: The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.


name: positive regulation of chemokine (C-X-C motif) ligand 1 production

description: Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production.


name: RHBL3_HUMAN Rhomboid-related protein 3 (sprot)

description: A rhomboid-related protein 3 that is encoded in the genome of human.


name: H2B1D_HUMAN Histone H2B type 1-D (sprot)

description: A histone H2B type 1-D that is encoded in the genome of human.


name: DSCR9_HUMAN Down syndrome critical region protein 9 (sprot)

description: A Down syndrome critical region protein 9 that is encoded in the genome of human.


name: DSC10_HUMAN Down syndrome critical region protein 10 (sprot)

description: A Down syndrome critical region protein 10 that is encoded in the genome of human.


name: RTP1_HUMAN Receptor-transporting protein 1 (sprot)

description: A receptor-transporting protein 1 that is encoded in the genome of human.


olfactory receptor binding

description: Binding to an olfactory receptor.


name: NLRP6_HUMAN NACHT, LRR and PYD domains-containing protein 6 (sprot)

description: A NACHT, LRR and PYD domains-containing protein 6 that is encoded in the genome of human.


regulation of mucus secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.


NLRP6 inflammasome complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a NLRP6 inflammasome complex.


non-membrane-bounded organelle

description: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.


NLRP6 inflammasome complex

description: An inflammasome complex that consists of NLRP6, PYCARD/ASC and caspase-1 or caspase-4/caspase-11.


name: NAL11_HUMAN NACHT, LRR and PYD domains-containing protein 11 (sprot)

description: A NACHT, LRR and PYD domains-containing protein 11 that is encoded in the genome of human.


name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

description: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor.


name: NAL12_HUMAN NACHT, LRR and PYD domains-containing protein 12 (sprot)

description: A NACHT, LRR and PYD domains-containing protein 12 that is encoded in the genome of human.


regulation of interleukin-18 production

description: Any process that modulates the frequency, rate, or extent of interleukin-18 production.


name: negative regulation of Toll signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway.


name: NALP5_HUMAN NACHT, LRR and PYD domains-containing protein 5 (sprot)

description: A NACHT, LRR and PYD domains-containing protein 5 that is encoded in the genome of human.


regulation of localization

description: Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.


establishment of organelle localization

description: The directed movement of an organelle to a specific location.


name: CHM4P_HUMAN Putative charged multivesicular body protein 4B-like protein CHMP4BP1 (sprot)


name: STAR6_HUMAN StAR-related lipid transfer protein 6 (sprot)

description: A StAR-related lipid transfer protein 6 that is encoded in the genome of human.


name: DAOA_HUMAN D-amino acid oxidase regulator (sprot)

description: A D-amino acid oxidase activator that is encoded in the genome of human.


D-amino acid metabolic process

description: The chemical reactions and pathways involving D-amino acids, the D-enantiomers of amino acids.


name: RAB15_HUMAN Ras-related protein Rab-15 (sprot)

description: A Ras-related protein Rab-15 that is encoded in the genome of human.


name: TPPP2_HUMAN Tubulin polymerization-promoting protein family member 2 (sprot)

description: A tubulin polymerization-promoting protein family member 2 that is encoded in the genome of human.


name: regulation of flagellated sperm motility

description: Any process that modulates the frequency, rate or extent of flagellated sperm motility.


name: ATS20_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 20 (sprot)

description: An a disintegrin and metalloproteinase with thrombospondin motifs 20 that is encoded in the genome of human.


name: T2R38_HUMAN Taste receptor type 2 member 38 (sprot)

description: A taste receptor type 2 member 38 that is encoded in the genome of human.


name: T2R39_HUMAN Taste receptor type 2 member 39 (sprot)

description: A taste receptor type 2 member 39/139 that is encoded in the genome of human.


name: T2R40_HUMAN Taste receptor type 2 member 40 (sprot)

description: A taste receptor type 2 member 40 that is encoded in the genome of human.


name: T2R41_HUMAN Taste receptor type 2 member 41 (sprot)

description: A taste receptor type 2 member 41 that is encoded in the genome of human.


name: T2R43_HUMAN Taste receptor type 2 member 43 (sprot)

description: A taste receptor type 2 member 43 that is encoded in the genome of human.


taste receptor activity

description: Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.


name: T2R31_HUMAN Taste receptor type 2 member 31 (sprot)

description: A taste receptor type 2 member 31 that is encoded in the genome of human.


name: T2R45_HUMAN Taste receptor type 2 member 45 (sprot)

description: A taste receptor type 2 member 45 that is encoded in the genome of human.


name: T2R46_HUMAN Taste receptor type 2 member 46 (sprot)

description: A taste receptor type 2 member 46 that is encoded in the genome of human.


name: T2R30_HUMAN Taste receptor type 2 member 30 (sprot)

description: A taste receptor type 2 member 30 that is encoded in the genome of human.


name: T2R19_HUMAN Taste receptor type 2 member 19 (sprot)

description: A taste receptor type 2 member 19 that is encoded in the genome of human.


name: T2R20_HUMAN Taste receptor type 2 member 20 (sprot)

description: A taste receptor type 2 member 20 that is encoded in the genome of human.


name: T2R50_HUMAN Taste receptor type 2 member 50 (sprot)

description: A taste receptor type 2 member 50 that is encoded in the genome of human.


name: T2R60_HUMAN Taste receptor type 2 member 60 (sprot)

description: A taste receptor type 2 member 60/135 that is encoded in the genome of human.


sensory perception of bitter taste

description: The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


name: FXYD4_HUMAN FXYD domain-containing ion transport regulator 4 (sprot)

description: An FXYD domain-containing ion transport regulator 4 that is encoded in the genome of human.


name: DEF1_HUMAN Neutrophil defensin 1 (sprot)

description: A protein that is a translation product of any of the following genes in human: DEFA1/DEFA1B.


name: DEF3_HUMAN Neutrophil defensin 3 (sprot)

description: A protein that is a translation product of the DEFA3 gene in human.


name: GBG2_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (sprot)

description: A guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 that is encoded in the genome of human.


name: MNARL_HUMAN Major intrinsically disordered NOTCH2-binding receptor 1-like (sprot)

description: A major intrinsically disordered NOTCH2-binding receptor 1-like that is encoded in the genome of human.


name: AP3S2_HUMAN AP-3 complex subunit sigma-2 (sprot)

description: An AP-3 complex subunit sigma-2 (human), isoforms 1 and 3.


Golgi to vacuole transport

description: The directed movement of substances from the Golgi to the vacuole.


name: GPX6_HUMAN Glutathione peroxidase 6 (sprot)

description: A glutathione peroxidase 6 that is encoded in the genome of human.


SELV_HUMAN Selenoprotein V (sprot)

A selenoprotein V that is encoded in the genome of human.


name: Z280A_HUMAN Zinc finger protein 280A (sprot)

description: A zinc finger protein 280A that is encoded in the genome of human.


name: BPIB3_HUMAN BPI fold-containing family B member 3 (sprot)

description: A BPI fold-containing family B member 3 that is encoded in the genome of human.


name: BPIB4_HUMAN BPI fold-containing family B member 4 (sprot)

description: A BPI fold-containing family B member 4 that is encoded in the genome of human.


D131A_HUMAN Beta-defensin 131A (sprot)

A beta-defensin 131A that is encoded in the genome of human.


name: LIRA4_HUMAN Leukocyte immunoglobulin-like receptor subfamily A member 4 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily A member 4 that is encoded in the genome of human.


name: negative regulation of toll-like receptor 7 signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 7 signaling pathway.


Fc-epsilon receptor I complex

description: A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE.


name: DJB13_HUMAN DnaJ homolog subfamily B member 13 (sprot)

description: A DnaJ homolog subfamily B member 13 that is encoded in the genome of human.


axonemal central apparatus assembly

description: The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus.


name: OR2B8_HUMAN Putative olfactory receptor 2B8 (sprot)


name: ZN445_HUMAN Zinc finger protein 445 (sprot)

description: A zinc finger protein 445 that is encoded in the genome of human.


name: epigenetic programing of female pronucleus

description: The global programming of epigenetic modifications in the female pronucleus of the newly fertilized zygote. The maternal genome is protected from global DNA demethylation before the first division of the zygote, and instead undergoes passive, replication-dependent demethylation during early embryogenesis, arising from inhibition of the DNA maintenance methyltransferase Dnmt1.


name: MCCD1_HUMAN Mitochondrial coiled-coil domain protein 1 (sprot)

description: A mitochondrial coiled-coil domain protein 1 that is encoded in the genome of human.


name: KR121_HUMAN Keratin-associated protein 12-1 (sprot)

description: A keratin-associated protein 12-1 that is encoded in the genome of human.


name: KR122_HUMAN Keratin-associated protein 12-2 (sprot)

description: A keratin-associated protein 12-2 that is encoded in the genome of human.