apolipoprotein A-I receptor activity

description: Combining with an apolipoprotein A-I receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


sphingolipid floppase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the movement of a sphingolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.


cholesterol transfer activity

description: Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


floppase activity

description: Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.


peptide secretion

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The controlled release of a peptide from a cell or a tissue.


phagocytosis, engulfment

description: The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.


name: negative regulation of macrophage derived foam cell differentiation

description: Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.


name: negative regulation of cholesterol storage

description: Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


signal release

description: The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.


response to vitamin B3

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus.


phospholipid efflux

description: The directed movement of a phospholipid out of a cell or organelle.


name: apolipoprotein A-I-mediated signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by apolipoprotein A-I binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


lipoprotein biosynthetic process

description: The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.


name: regulation of high-density lipoprotein particle assembly

description: Any process that modulates the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.


name: positive regulation of high-density lipoprotein particle assembly

description: Any process that increases the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.


sphingolipid translocation

description: The movement of a sphingolipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.


name: NSA2_HUMAN Ribosome biogenesis protein NSA2 homolog (sprot)

description: A ribosome biogenesis protein NSA2 that is encoded in the genome of human.


name: G6PE_HUMAN GDH/6PGL endoplasmic bifunctional protein (sprot)

description: A GDH/6PGL endoplasmic bifunctional protein that is encoded in the genome of human.


description: Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.


glucose 1-dehydrogenase (NAD+) activity

description: Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH.


name: glucose 1-dehydrogenase (NADP+) activity

description: Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH.


name: glucose 1-dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H.


name: pentose-phosphate shunt, oxidative branch

description: The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2).


response to alcohol

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus.


name: regulation of cortisol biosynthetic process

description: Any process that modulates the frequency, rate or extent of cortisol biosynthetic process.


CLD9_HUMAN Claudin-9 (sprot)

A claudin-9 that is encoded in the genome of human.


name: SC24A_HUMAN Protein transport protein Sec24A (sprot)

description: A protein transport protein Sec24A that is encoded in the genome of human.


regulation of cholesterol transport

description: Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: SC24B_HUMAN Protein transport protein Sec24B (sprot)

description: A protein transport protein Sec24B that is encoded in the genome of human.


cochlear nucleus development

description: The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure.


lung lobe morphogenesis

description: The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung.


pulmonary artery morphogenesis

description: The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs.


name: regulation of establishment of planar polarity involved in neural tube closure

description: Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube.


name: regulation of cargo loading into COPII-coated vesicle

description: Any process that modulates the frequency, rate or extent of cargo loading into COPII-coated vesicle.


name: AGRL2_HUMAN Adhesion G protein-coupled receptor L2 (sprot)

description: An adhesion G protein-coupled receptor L2 that is encoded in the genome of human.


VNN1_HUMAN Pantetheinase (sprot)

A pantetheinase that is encoded in the genome of human.


pantetheine hydrolase activity

description: Catalysis of the reaction: (R)-pantetheine + H2O = (R)-pantothenate + cysteamine.


pantothenate metabolic process

description: The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.


name: positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

description: Any process that activates or increases the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.


name: VNN2_HUMAN Pantetheine hydrolase VNN2 (sprot)

description: A pantetheine hydrolase VNN2 that is encoded in the genome of human.


CLD14_HUMAN Claudin-14 (sprot)

A claudin-14 that is encoded in the genome of human.


name: NPTXR_HUMAN Neuronal pentraxin receptor (sprot)

description: A neuronal pentraxin receptor that is encoded in the genome of human.


name: CBX6_HUMAN Chromobox protein homolog 6 (sprot)

description: A chromobox protein homolog 6 that is encoded in the genome of human.


name: PRAM1_HUMAN PRAME family member 1 (sprot)

description: A PRAME family member 1 that is encoded in the genome of human.


name: PRA12_HUMAN PRAME family member 12 (sprot)

description: A PRAME family member 12 that is encoded in the genome of human.


name: GTR10_HUMAN Solute carrier family 2, facilitated glucose transporter member 10 (sprot)

description: A solute carrier family 2, facilitated glucose transporter member 10 that is encoded in the genome of human.


name: negative regulation of integrin-mediated signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of integrin-mediated signaling pathway.


name: negative regulation of connective tissue growth factor production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production.


artery development

description: The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed.


name: negative regulation of proteoglycan biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


name: positive regulation of proteoglycan biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


name: carbohydrate:proton symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in).


name: dehydroascorbic acid transmembrane transporter activity

description: Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other.


name: D-glucose transmembrane transporter activity

description: Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other.


galactose transmembrane transport

description: The process in which galactose is transported across a lipid bilayer, from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.


dehydroascorbic acid transport

description: The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C.


glucose import across plasma membrane

description: The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol.


NADK_HUMAN NAD kinase (sprot)

An NAD kinase that is encoded in the genome of human.


NAD+ kinase activity

description: Catalysis of the reaction: ATP + NAD+ = ADP + 2 H+ + NADP+.


name: TYDP2_HUMAN Tyrosyl-DNA phosphodiesterase 2 (sprot)

description: A tyrosyl-DNA phosphodiesterase 2 that is encoded in the genome of human.


tyrosyl-RNA phosphodiesterase activity

description: Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis.


description: Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA.


name: CA105_HUMAN Uncharacterized protein C1orf105 (sprot)

description: An uncharacterized protein C1orf105 that is encoded in the genome of human.


name: SFT2B_HUMAN Vesicle transport protein SFT2B (sprot)

description: A vesicle transport protein SFT2B that is encoded in the genome of human.


name: MPC2_HUMAN Mitochondrial pyruvate carrier 2 (sprot)

description: A brain protein 44 that is encoded in the genome of human.


name: mitochondrial pyruvate transmembrane transport

description: The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: inner mitochondrial membrane protein complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any protein complex that is part of the inner mitochondrial membrane.


name: MET18_HUMAN Histidine protein methyltransferase 1 homolog (sprot)

description: A histidine protein methyltransferase 1 homolog that is encoded in the genome of human.


description: Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine.


regulation of translational elongation

description: Any process that modulates the frequency, rate, extent or accuracy of translational elongation.


regulation of ribosome biogenesis

description: Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.


regulation of rRNA processing

description: Any process that modulates the frequency, rate or extent of rRNA processing.


name: ETHE1_HUMAN Persulfide dioxygenase ETHE1, mitochondrial (sprot)

description: A persulfide dioxygenase ETHE1, mitochondrial that is encoded in the genome of human.


sulfur dioxygenase activity

description: Catalysis of the reaction: S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H+.


hydrogen sulfide metabolic process

description: The chemical reactions and pathways involving hydrogen sulfide, H2S.


name: ACSL3_HUMAN Fatty acid CoA ligase Acsl3 (sprot)

description: A fatty acid CoA ligase Acsl3 that is encoded in the genome of human.


name: medium-chain fatty acid-CoA ligase activity

description: Catalysis of the reaction: a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.


name: positive regulation of Golgi to plasma membrane protein transport

description: Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.


positive regulation of secretion

description: Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.


name: positive regulation of phosphatidylcholine biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process.


name: KLF8_HUMAN Krueppel-like factor 8 (sprot)

description: A krueppel-like factor 8 that is encoded in the genome of human.


name: RPA1_HUMAN DNA-directed RNA polymerase I subunit RPA1 (sprot)

description: A DNA-directed RNA polymerase I subunit RPA1 that is encoded in the genome of human.


RNA polymerase I activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


name: negative regulation of protein localization to nucleolus

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus.


PCNT_HUMAN Pericentrin (sprot)

A pericentrin that is encoded in the genome of human.


name: YETS4_HUMAN YEATS domain-containing protein 4 (sprot)

description: A YEATS domain-containing protein 4 that is encoded in the genome of human.


modification-dependent protein binding

description: Binding to a protein upon post-translation modification of the target protein.


name: regulation of double-strand break repair

description: Any process that modulates the frequency, rate or extent of double-strand break repair.


NuA4 histone acetyltransferase complex

description: A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).


name: DUS4L_HUMAN tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (sprot)

description: A tRNA-dihydrouridine synthase 4-like that is encoded in the genome of human.


description: Catalysis of the reaction: a 5,6-dihydrouracil20a in tRNA + NAD(P) = H+ + a uracil20a in tRNA + NAD(P)H.


description: Catalysis of the reaction: a 5,6-dihydrouracil20b in tRNA + NAD(P) = H+ + a uracil20b in tRNA + NAD(P)H.


tRNA dihydrouridine synthesis

description: The process whereby a uridine in a transfer RNA is converted to dihydrouridine.


name: ADCY5_HUMAN Adenylate cyclase type 5 (sprot)

description: An adenylate cyclase type 5 that is encoded in the genome of human.


adenylate cyclase binding

description: Binding to an adenylate cyclase.


name: G protein-coupled adenosine receptor signaling pathway

description: The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.


name: adenylate cyclase-inhibiting dopamine receptor signaling pathway

description: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process.


name: ZBT11_HUMAN Zinc finger and BTB domain-containing protein 11 (sprot)

description: A zinc finger and BTB domain-containing protein 11 that is encoded in the genome of human.


name: CNOT4_HUMAN CCR4-NOT transcription complex subunit 4 (sprot)

description: A CCR4-NOT transcription complex subunit 4 that is encoded in the genome of human.


name: regulation of megakaryocyte differentiation

description: Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.


name: STABP_HUMAN STAM-binding protein (sprot)

description: A STAM-binding protein that is encoded in the genome of human.


deubiquitinase activity

description: An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.


hippocampal neuron apoptotic process

description: Any apoptotic process that occurs in a hippocampal neuron.


name: negative regulation of hippocampal neuron apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons.


NET1_HUMAN Netrin-1 (sprot)

A netrin-1 that is encoded in the genome of human.


mammary gland duct morphogenesis

description: The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk.


regulation of glial cell migration

description: Any process that modulates the frequency, rate or extent of glial cell migration.


name: FSTL3_HUMAN Follistatin-related protein 3 (sprot)

description: A follistatin-related protein 3 that is encoded in the genome of human.


activin binding

description: Binding to activin, a dimer of inhibin-beta subunits.


name: negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

description: Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.


name: CPSF4_HUMAN Cleavage and polyadenylation specificity factor subunit 4 (sprot)

description: A cleavage and polyadenylation specificity factor subunit 4 that is encoded in the genome of human.


name: NFAC1_HUMAN Nuclear factor of activated T-cells, cytoplasmic 1 (sprot)

description: A nuclear factor of activated T-cells, cytoplasmic 1 that is encoded in the genome of human.


name: mitogen-activated protein kinase p38 binding

description: Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation.


skeletal muscle adaptation

description: Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals.


mononuclear cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell.


name: negative regulation of vascular associated smooth muscle cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation.


name: positive regulation of DNA biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.


name: DIRA3_HUMAN GTP-binding protein Di-Ras3 (sprot)

description: A GTP-binding protein Di-Ras3 that is encoded in the genome of human.


genomic imprinting

description: The establishment of epigenetic modifications (imprints) during gametogenesis, and propagation of these imprints during the organism's life. Genomic imprinting leads to an asymmetry between the maternal and paternal alleles and differential expression of the corresponding alleles. This can happen through heterochromatin formation or differential chromatin loop formation.


name: NTR2_HUMAN Neurotensin receptor type 2 (sprot)

description: A neurotensin receptor type 2 that is encoded in the genome of human.


sensory perception

description: The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


name: VATG2_HUMAN V-type proton ATPase subunit G 2 (sprot)

description: A V-type proton ATPase subunit G 2 that is encoded in the genome of human.


name: ASML_HUMAN Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (sprot)

description: A probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein that is encoded in the genome of human.


O-methyltransferase activity

description: Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.


dTTP diphosphatase activity

description: Catalysis of the reaction: dTTP + H2O = dTMP + H+ + diphosphate.


UTP diphosphatase activity

description: Catalysis of the reaction: UTP + H2O = UMP + H+ + diphosphate.


nucleotide metabolic process

description: The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).


name: ECEL1_HUMAN Endothelin-converting enzyme-like 1 (sprot)

description: An endothelin-converting enzyme-like 1 that is encoded in the genome of human.


name: CDS2_HUMAN Phosphatidate cytidylyltransferase 2 (sprot)

description: A phosphatidate cytidylyltransferase 2 that is encoded in the genome of human.


description: Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol.


description: The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.


name: EYA4_HUMAN Eyes absent homolog 4 (sprot)

description: An eyes absent homolog 4 that is encoded in the genome of human.


name: K2C75_HUMAN Keratin, type II cytoskeletal 75 (sprot)

description: A keratin, type II cytoskeletal 75 that is encoded in the genome of human.


name: CEP43_HUMAN Centrosomal protein 43 (sprot)

description: A centrosomal protein 43 that is encoded in the genome of human.


name: PPR3D_HUMAN Protein phosphatase 1 regulatory subunit 3D (sprot)

description: A protein phosphatase 1 regulatory subunit 3D that is encoded in the genome of human.


name: regulation of glycogen catabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.


glycogen granule

description: Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface.


name: BRD1_HUMAN Bromodomain-containing protein 1 (sprot)

description: A bromodomain-containing protein 1 that is encoded in the genome of human.


regulation of developmental process

description: Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).


regulation of hemopoiesis

description: Any process that modulates the frequency, rate or extent of hemopoiesis.


name: MOZ/MORF histone acetyltransferase complex

description: A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.


name: APBB3_HUMAN Amyloid-beta A4 precursor protein-binding family B member 3 (sprot)

description: An amyloid-beta A4 precursor protein-binding family B member 3 that is encoded in the genome of human.


name: RPP29_HUMAN Ribonuclease P protein subunit p29 (sprot)

description: A ribonuclease P protein subunit p29 that is encoded in the genome of human.


name: LY86_HUMAN Lymphocyte antigen 86 (sprot)

description: A lymphocyte antigen 86 that is encoded in the genome of human.


name: HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 (sprot)

description: An E3 ubiquitin-protein ligase HERC2 that is encoded in the genome of human.


name: CXL14_HUMAN C-X-C motif chemokine 14 (sprot)

description: A C-X-C motif chemokine 14 that is encoded in the genome of human.


name: RAB3D_HUMAN Ras-related protein Rab-3D (sprot)

description: A Ras-related protein Rab-3D that is encoded in the genome of human.


name: positive regulation of regulated secretory pathway

description: Any process that activates or increases the frequency, rate or extent of regulated secretory pathway.


zymogen granule

description: A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.


secretory vesicle

description: A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.


name: ERR2_HUMAN Steroid hormone receptor ERR2 (sprot)

description: A steroid hormone receptor ERR2 that is encoded in the genome of human.


embryonic placenta development

description: The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.


integrator complex

description: A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II.


stem cell division

description: The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.


name: SNP29_HUMAN Synaptosomal-associated protein 29 (sprot)

description: A synaptosomal-associated protein 29 that is encoded in the genome of human.


autophagosome membrane docking

description: The initial attachment of an autophagosome membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere.


ciliary pocket membrane

description: That part of the plasma membrane found in the ciliary pocket (also called flagellar pocket).


name: CRTAM_HUMAN Cytotoxic and regulatory T-cell molecule (sprot)

description: A cytotoxic and regulatory T-cell molecule that is encoded in the genome of human.


detection of tumor cell

description: The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal.


name: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

description: Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.


regulation of T cell differentiation

description: Any process that modulates the frequency, rate or extent of T cell differentiation.


detection of stimulus

description: The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal.


name: lymphocyte migration into lymphoid organs

description: The movement of a lymphocyte within the lymphatic system into lymphoid organs such as lymph nodes, spleen or Peyer's patches, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen.


name: regulation of CD8-positive, alpha-beta T cell activation

description: Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.


CPNE6_HUMAN Copine-6 (sprot)

A copine-6 that is encoded in the genome of human.


name: PM2P2_HUMAN Putative postmeiotic segregation increased 2-like protein 2 (sprot)

description: A putative postmeiotic segregation increased 2-like protein 2 that is encoded in the genome of human.


name: OXSR1_HUMAN Serine/threonine-protein kinase OSR1 (sprot)

description: A serine/threonine-protein kinase OSR1 that is encoded in the genome of human.


osmosensory signaling pathway

description: The series of molecular signals initiated in response to osmotic change.


name: chemokine (C-X-C motif) ligand 12 signaling pathway

description: The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


cellular hypotonic response

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.


name: GGPPS_HUMAN Geranylgeranyl pyrophosphate synthase (sprot)

description: A geranylgeranyl pyrophosphate synthase that is encoded in the genome of human.


dimethylallyltranstransferase activity

description: Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.


farnesyltranstransferase activity

description: Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.


geranyltranstransferase activity

description: Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate.


name: geranyl diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of geranyl diphosphate.


name: geranylgeranyl diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate.


name: farnesyl diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of farnesyl diphosphate.


name: FGF19_HUMAN Fibroblast growth factor 19 (sprot)

description: A fibroblast growth factor 19 that is encoded in the genome of human.


name: negative regulation of bile acid biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.


LDOC1_HUMAN Protein LDOC1 (sprot)

A protein LDOC1 that is encoded in the genome of human.


name: maternal process involved in parturition

description: A reproductive process occurring in the mother that results in birth.


SEM4F_HUMAN Semaphorin-4F (sprot)

A semaphorin-4F that is encoded in the genome of human.


name: RAB36_HUMAN Ras-related protein Rab-36 (sprot)

description: A Ras-related protein Rab-36 that is encoded in the genome of human.


name: HS74L_HUMAN Heat shock 70 kDa protein 4L (sprot)

description: A heat shock 70 kDa protein 4L that is encoded in the genome of human.


name: PTBP3_HUMAN Polypyrimidine tract-binding protein 3 (sprot)

description: A regulator of differentiation 1 that is encoded in the genome of human.


negative regulation of RNA splicing

description: Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing.


name: TBCD8_HUMAN TBC1 domain family member 8 (sprot)

description: A TBC1 domain family member 8 that is encoded in the genome of human.


blood circulation

description: The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.


IL33_HUMAN Interleukin-33 (sprot)

An interleukin-33 that is encoded in the genome of human.


name: positive regulation of cellular defense response

description: Any process that activates or increases the frequency, rate or extent of cellular defense response.


name: negative regulation of macrophage proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage proliferation.


positive regulation of CD86 production

description: Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process.


positive regulation of CD80 production

description: Any process that activates or increases the frequency, rate or extent of CD80 biosynthetic process.


interleukin-33 receptor binding

description: Binding to an interleukin-33 receptor.


name: negative regulation of immunoglobulin production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production.


name: positive regulation of immunoglobulin production

description: Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.


name: negative regulation of leukocyte migration

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.


name: negative regulation of T-helper 1 type immune response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response.


name: positive regulation of type 2 immune response

description: Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.


name: positive regulation of interleukin-5 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-5 production.


name: positive regulation of MHC class I biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.


microglial cell proliferation

description: The expansion of a microglial cell population by cell division.


name: STR3N_HUMAN STARD3 N-terminal-like protein (sprot)

description: A STARD3 N-terminal-like protein that is encoded in the genome of human.


name: vesicle tethering to endoplasmic reticulum

description: The initial, indirect interaction between a transport vesicle membrane and the membrane of the endoplasmic reticulum. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.


name: LSM8_HUMAN U6 snRNA-associated Sm-like protein LSm8 (sprot)

description: A U6 snRNA-associated Sm-like protein LSm8 that is encoded in the genome of human.


U6 snRNA binding

description: Binding to a U6 small nuclear RNA (U6 snRNA).


Lsm2-8 complex

description: A heteroheptameric, nuclear protein complex composed of Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Lsm8, or orthologs thereof, that selectively binds to snRNAs, in particular U6 or U6atac snRNAs, and also to unspliced transcripts localized within the nucleus.


name: ZN682_HUMAN Zinc finger protein 682 (sprot)

description: A zinc finger protein 682 that is encoded in the genome of human.


name: AP2A1_HUMAN AP-2 complex subunit alpha-1 (sprot)

description: An AP-2 complex subunit alpha-1 that is encoded in the genome of human.


name: negative regulation of hyaluronan biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process.


filopodium tip

description: The end of a filopodium distal to the body of the cell.


name: clathrin coat of trans-Golgi network vesicle

description: A clathrin coat found on a vesicle of the trans-Golgi network.


WIZ_HUMAN Protein Wiz (sprot)

A protein Wiz that is encoded in the genome of human.


name: RIGI_HUMAN Antiviral innate immune response receptor RIG-I (sprot)

description: An antiviral innate immune response receptor RIG-I that is encoded in the genome of human.


name: positive regulation of myeloid dendritic cell cytokine production

description: Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.


name: regulation of type III interferon production

description: Any process that modulates the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far.


RIG-I signaling pathway

description: The series of molecular signals initiated by the binding ssRNA or dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.


name: positive regulation of response to cytokine stimulus

description: Any process that increases the rate, frequency, or extent of a response to cytokine stimulus.


name: ZMYM6_HUMAN Zinc finger MYM-type protein 6 (sprot)

description: A zinc finger MYM-type protein 6 that is encoded in the genome of human.


name: STAU1_HUMAN Double-stranded RNA-binding protein Staufen homolog 1 (sprot)

description: A double-stranded RNA-binding protein Staufen homolog 1 that is encoded in the genome of human.


name: lncRNA-mediated post-transcriptional gene silencing

description: A post-transcriptional gene silencing pathway in which regulatory long noncoding RNAs (lncRNAs) elicit silencing of specific target genes, often miRNAs or mRNAs.


name: positive regulation by virus of viral protein levels in host cell

description: Any process where the infecting virus increases the levels of viral proteins in a cell.


modification of postsynaptic structure

description: Any process that modifies the structure of a postsynapse.


name: GPR75_HUMAN Probable G-protein coupled receptor 75 (sprot)

description: A probable G-protein coupled receptor 75 that is encoded in the genome of human.


C-C chemokine receptor activity

description: Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.


name: TTC4_HUMAN Tetratricopeptide repeat protein 4 (sprot)

description: A tetratricopeptide repeat protein 4 that is encoded in the genome of human.


name: NDST3_HUMAN Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (sprot)

description: A bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 that is encoded in the genome of human.


name: [heparan sulfate]-glucosamine N-sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine.


heparan sulfate N-deacetylase activity

description: Catalysis of the reaction: H2O + [heparan sulfate]-N-acetyl-alpha-D-glucosamine = acetate + H+ + [heparan sulfate]-alpha-D-glucosamine.


name: heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

description: The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan.


name: TM50A_HUMAN Transmembrane protein 50A (sprot)

description: A transmembrane protein 50A that is encoded in the genome of human.


glial cell projection

description: A prolongation or process extending from a glial cell.


name: CAVN2_HUMAN Caveolae-associated protein 2 (sprot)

description: A caveolae-associated protein 2 that is encoded in the genome of human.


plasma membrane tubulation

description: A membrane tubulation process occurring in a plasma membrane.


CER1_HUMAN Cerberus (sprot)

A cerberus that is encoded in the genome of human.


name: growth plate cartilage chondrocyte proliferation

description: The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.


gastrulation

description: A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.


name: sequestering of BMP in extracellular matrix

description: Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.


name: negative regulation of mesoderm development

description: Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development.


name: BAG2_HUMAN BAG family molecular chaperone regulator 2 (sprot)

description: A BAG family molecular chaperone regulator 2 that is encoded in the genome of human.


dendritic microtubule

description: Any microtubule in a dendrite, a neuron projection.


name: adenyl-nucleotide exchange factor activity

description: Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.


name: positive regulation of protein processing

description: Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage.


name: negative regulation of ubiquitin protein ligase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity.


name: BAG3_HUMAN BAG family molecular chaperone regulator 3 (sprot)

description: A BAG family molecular chaperone regulator 3 that is encoded in the genome of human.


protein transport along microtubule

description: The directed movement of a protein along a microtubule, mediated by motor proteins.


dynein intermediate chain binding

description: Binding to an intermediate chain of the dynein complex.


protein carrier chaperone

description: Binding to and carrying a protein between two different cellular components by moving along with the target protein.


striated muscle cell apoptotic process

description: A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations.


name: negative regulation of striated muscle cell apoptotic process

description: Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.


chaperone-mediated autophagy

description: The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded.


positive regulation of aggrephagy

description: Any process that activates or increases the frequency, rate or extent of aggrephagy.


name: M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 (sprot)

description: A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of human.


creatine kinase activity

description: Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H+.


name: positive regulation of ARF protein signal transduction

description: Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction.


positive regulation of hippo signaling

description: Any process that activates or increases the frequency, rate or extent of hippo signaling.


name: positive regulation of focal adhesion disassembly

description: Any process that activates or increases the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components.


name: DCMC_HUMAN Malonyl-CoA decarboxylase, mitochondrial (sprot)

description: A malonyl-CoA decarboxylase, mitochondrial that is encoded in the genome of human.


malonyl-CoA decarboxylase activity

description: Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2.


acetyl-CoA biosynthetic process

description: The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.


name: positive regulation of fatty acid oxidation

description: Any process that activates or increases the frequency, rate or extent of fatty acid oxidation.


name: QORL1_HUMAN Quinone oxidoreductase-like protein 1 (sprot)

description: A quinone oxidoreductase-like protein 1 that is encoded in the genome of human.


name: NADPH:quinone reductase activity

description: Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone.


quinone metabolic process

description: The chemical reactions and pathways involving quinone.


name: AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (sprot)

description: An apoptosis-inducing factor 1, mitochondrial that is encoded in the genome of human.


name: oxidoreductase activity, acting on NAD(P)H

description: Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


poly-ADP-D-ribose binding

description: Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring.


chromosome condensation

description: The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.


name: mitochondrial respiratory chain complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.


name: protein import into mitochondrial intermembrane space

description: The import of proteins into the space between the inner and outer mitochondrial membranes.


name: positive regulation of necroptotic process

description: Any process that increases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.


CLD1_HUMAN Claudin-1 (sprot)

A claudin-1 that is encoded in the genome of human.


establishment of blood-nerve barrier

description: The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier.


name: xenobiotic transport across blood-nerve barrier

description: The directed movement of a xenobiotic through the blood-nerve barrier.


cellular response to lead ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.


name: establishment of endothelial intestinal barrier

description: The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.


cellular response to butyrate

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus.


name: CLIC3_HUMAN Chloride intracellular channel protein 3 (sprot)

description: A chloride intracellular channel protein 3 that is encoded in the genome of human.


name: protein-disulfide reductase (glutathione) activity

description: Catalysis of the reaction: 2 glutathione + protein-disulfide = glutathione disulfide+ protein-dithiol.


name: EMAL2_HUMAN Echinoderm microtubule-associated protein-like 2 (sprot)

description: An echinoderm microtubule-associated protein-like 2 that is encoded in the genome of human.


name: negative regulation of microtubule polymerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.


name: LATS1_HUMAN Serine/threonine-protein kinase LATS1 (sprot)

description: A serine/threonine-protein kinase LATS1 that is encoded in the genome of human.


sister chromatid segregation

description: The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.


inner cell mass cell fate commitment

description: The cell fate commitment of precursor cells that will become inner cell mass cells.


inner cell mass cellular morphogenesis

description: The morphogenesis of cells in the inner cell mass.


hippo signaling

description: An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.


cytoplasmic sequestering of protein

description: The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell.


name: regulation of ubiquitin-dependent protein catabolic process

description: Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


name: GNA14_HUMAN Guanine nucleotide-binding protein subunit alpha-14 (sprot)

description: A guanine nucleotide-binding protein subunit alpha-14 that is encoded in the genome of human.


name: GLP2R_HUMAN Glucagon-like peptide 2 receptor (sprot)

description: A glucagon-like peptide 2 receptor that is encoded in the genome of human.


cellular response to glucagon stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.


name: ANGL1_HUMAN Angiopoietin-related protein 1 (sprot)

description: An angiopoietin-related protein 1 that is encoded in the genome of human.


name: GUC1C_HUMAN Guanylyl cyclase-activating protein 3 (sprot)

description: A guanylyl cyclase-activating protein 3 that is encoded in the genome of human.


photoreceptor disc membrane

description: Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.


name: UCP4_HUMAN Mitochondrial uncoupling protein 4 (sprot)

description: A mitochondrial uncoupling protein 4 that is encoded in the genome of human.


intracellular triglyceride homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of triglyceride within a cell.


name: NUD14_HUMAN Uridine diphosphate glucose pyrophosphatase NUDT14 (sprot)

description: A uridine diphosphate glucose pyrophosphatase NUDT14 that is encoded in the genome of human.


UDP-sugar diphosphatase activity

description: Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate.


TSN13_HUMAN Tetraspanin-13 (sprot)

A tetraspanin-13 that is encoded in the genome of human.


name: regulation of calcium ion transmembrane transport

description: Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport.


TSN15_HUMAN Tetraspanin-15 (sprot)

A tetraspanin-15 that is encoded in the genome of human.


name: regulation of membrane protein ectodomain proteolysis

description: Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).


TSN12_HUMAN Tetraspanin-12 (sprot)

A tetraspanin-12 that is encoded in the genome of human.


name: BPNT1_HUMAN 3'(2'),5'-bisphosphate nucleotidase 1 (sprot)

description: A 3'(2'),5'-bisphosphate nucleotidase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.


description: Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate.


name: SNAI1_HUMAN Zinc finger protein SNAI1 (sprot)

description: A zinc finger protein SNAI1 that is encoded in the genome of human.


epithelial cell migration

description: The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.


name: negative regulation of cell differentiation involved in embryonic placenta development

description: Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state.


left/right pattern formation

description: The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.


heterochromatin organization

description: Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin.


name: FADS2_HUMAN Acyl-CoA 6-desaturase (sprot)

description: An acyl-CoA 6-desaturase that is encoded in the genome of human.


name: arachidonic acid metabolite production involved in inflammatory response

description: The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels.


name: positive regulation of cellular response to oxidative stress

description: Any process that activates or increases the frequency, rate or extent of cellular response to oxidative stress.


name: DDAH2_HUMAN Putative hydrolase DDAH2 (sprot)

description: A putative hydrolase DDAH2 that is encoded in the genome of human.


name: G6B_HUMAN Megakaryocyte and platelet inhibitory receptor G6b (sprot)

description: A megakaryocyte and platelet inhibitory receptor G6b that is encoded in the genome of human.


name: LY66C_HUMAN Lymphocyte antigen 6 complex locus protein G6c (sprot)

description: A lymphocyte antigen 6 complex locus protein G6c that is encoded in the genome of human.


name: LY66D_HUMAN Lymphocyte antigen 6 complex locus protein G6d (sprot)

description: A lymphocyte antigen 6 complex locus protein G6d that is encoded in the genome of human.


name: ABHGA_HUMAN Phosphatidylserine lipase ABHD16A (sprot)

description: A phosphatidylserine lipase ABHD16A that is encoded in the genome of human.


phosphatidylserine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.


name: GPAN1_HUMAN G patch domain and ankyrin repeat-containing protein 1 (sprot)

description: A G patch domain and ankyrin repeat-containing protein 1 that is encoded in the genome of human.


name: CF047_HUMAN Uncharacterized protein C6orf47 (sprot)

description: An uncharacterized protein C6orf47 that is encoded in the genome of human.


name: FRITZ_HUMAN WD repeat-containing and planar cell polarity effector protein fritz homolog (sprot)

description: A WD repeat-containing and planar cell polarity effector protein fritz homolog that is encoded in the genome of human.


auditory receptor cell morphogenesis

description: Any process that alters the size or shape of an auditory receptor cell.


regulation of embryonic cell shape

description: Any process that modulates the surface configuration of an embryonic cell.


septin cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins.


podocyte cell migration

description: The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell.


regulation of ruffle assembly

description: Any process that modulates the frequency, rate or extent of ruffle assembly.


name: TXD12_HUMAN Thioredoxin domain-containing protein 12 (sprot)

description: A thioredoxin domain-containing protein 12 that is encoded in the genome of human.


name: DLGP3_HUMAN Disks large-associated protein 3 (sprot)

description: A disks large-associated protein 3 that is encoded in the genome of human.


signaling

description: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.


modification of synaptic structure

description: Any process that modifies the structure/morphology of a synapse.


cholinergic synapse

description: A synapse that uses acetylcholine as a neurotransmitter.


NOE2_HUMAN Noelin-2 (sprot)

A noelin-2 that is encoded in the genome of human.


name: regulation of vascular associated smooth muscle cell dedifferentiation

description: Any process that modulates the frequency, rate or extent of vascular smooth muscle cell dedifferentiation.


name: TRUB2_HUMAN Pseudouridylate synthase TRUB2, mitochondrial (sprot)

description: A pseudouridylate synthase TRUB2, mitochondrial that is encoded in the genome of human.


name: tRNA pseudouridine(55) synthase activity

description: Catalysis of the reaction: uridine(55) in tRNA = pseudouridine(55) in tRNA.


mRNA pseudouridine synthesis

description: The intramolecular conversion of uridine to pseudouridine in an mRNA molecule.


ribonucleoprotein granule

description: A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.


name: ECD_HUMAN Protein ecdysoneless homolog (sprot)

description: A protein ecdysoneless that is encoded in the genome of human.


name: MOT3_HUMAN Monocarboxylate transporter 3 (sprot)

description: A monocarboxylate transporter 3 that is encoded in the genome of human.


lactate transport

description: The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.


name: OR2H2_HUMAN Olfactory receptor 2H2 (sprot)

description: An olfactory receptor 2H2 that is encoded in the genome of human.


mating

description: The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.


name: TTLL1_HUMAN Polyglutamylase complex subunit TTLL1 (sprot)

description: A polyglutamylase complex subunit TTLL1 that is encoded in the genome of human.


name: immune response in nasopharyngeal-associated lymphoid tissue

description: An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids.


protein polyglutamylation

description: The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid.


name: cerebellar Purkinje cell differentiation

description: The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.


mucociliary clearance

description: The respiratory system process driven by motile cilia on epithelial cells of the respiratory tract by which mucus and associated inhaled particles and pathogens trapped within it are moved out of the airways.


EPPI_HUMAN Eppin (sprot)

An eppin that is encoded in the genome of human.


name: negative regulation of flagellated sperm motility

description: Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility.


name: SYF2_HUMAN Pre-mRNA-splicing factor SYF2 (sprot)

description: A pre-mRNA-splicing factor SYF2 that is encoded in the genome of human.


embryonic organ development

description: Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


name: CBX7_HUMAN Chromobox protein homolog 7 (sprot)

description: A chromobox protein homolog 7 that is encoded in the genome of human.


name: TGM3L_HUMAN Protein-glutamine gamma-glutamyltransferase 6 (sprot)

description: A protein-glutamine gamma-glutamyltransferase 6 that is encoded in the genome of human.


description: Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.


name: TBX18_HUMAN T-box transcription factor TBX18 (sprot)

description: A T-box transcription factor TBX18 that is encoded in the genome of human.


name: regulation of SA node cell action potential

description: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


name: neural plate anterior/posterior regionalization

description: The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.


sinoatrial node cell fate commitment

description: The commitment of cells to sinoatrial (SA) node cell fates and their capacity to differentiate into SA node cells. SA node cells are pacemaker cells that are found in the sinoatrial node.


ureter development

description: The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut.


name: EOMES_HUMAN Eomesodermin homolog (sprot)

description: An eomesodermin that is encoded in the genome of human.


name: CD8-positive, alpha-beta T cell differentiation involved in immune response

description: The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.


cardioblast differentiation

description: The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.


cerebral cortex regionalization

description: The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops.


mesendoderm development

description: The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues.


name: cell differentiation involved in embryonic placenta development

description: The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta.


name: mesodermal to mesenchymal transition involved in gastrulation

description: The epithelial to mesenchymal transition process in which a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation.


name: NCTR2_HUMAN Natural cytotoxicity triggering receptor 2 (sprot)

description: A natural cytotoxicity triggering receptor 2 that is encoded in the genome of human.


name: TBX6_HUMAN T-box transcription factor TBX6 (sprot)

description: A T-box transcription factor TBX6 that is encoded in the genome of human.


name: negative regulation of neuron maturation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation.


name: somite rostral/caudal axis specification

description: The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary.


name: ONEC2_HUMAN One cut domain family member 2 (sprot)

description: An one cut domain family member 2 that is encoded in the genome of human.


regulation of cell-matrix adhesion

description: Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.


epithelial cell development

description: The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.


endocrine pancreas development

description: The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.


name: peripheral nervous system neuron development

description: The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.


mesenchymal stem cell migration

description: The orderly movement of a mesenchymal stem cell from one site to another.


name: positive regulation of mesenchymal stem cell migration

description: Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration.


A formimidoyltransferase-cyclodeaminase that is encoded in the genome of human.


description: Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.


description: Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H+ = 5,10-methenyltetrahydrofolate + NH4.


name: folic acid-containing compound metabolic process

description: The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.


name: L-histidine catabolic process to glutamate and formamide

description: The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide.


name: L-histidine catabolic process to glutamate and formate

description: The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formate.


name: ITGBL_HUMAN Integrin beta-like protein 1 (sprot)

description: An integrin beta-like protein 1 that is encoded in the genome of human.


name: FBLN4_HUMAN EGF-containing fibulin-like extracellular matrix protein 2 (sprot)

description: An EGF-containing fibulin-like extracellular matrix protein 2 that is encoded in the genome of human.


elastic fiber assembly

description: Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching.


name: aorta smooth muscle tissue morphogenesis

description: The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.


name: regulation of collagen fibril organization

description: Any process that modulates the frequency, rate or extent of collagen fibril organization.


name: positive regulation of collagen fibril organization

description: Any process that activates or increases the frequency, rate or extent of collagen fibril organization.


name: negative regulation of vascular associated smooth muscle cell proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.


name: positive regulation of aortic smooth muscle cell differentiation

description: Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation.


name: positive regulation of smooth muscle cell-matrix adhesion

description: Any process that activates or increases the frequency, rate or extent of smooth muscle cell-matrix adhesion.


microfibril

description: Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.


elastic fiber

description: An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain.


name: SG1D1_HUMAN Secretoglobin family 1D member 1 (sprot)

description: A secretoglobin family 1D member 1 that is encoded in the genome of human.


name: SG1D2_HUMAN Secretoglobin family 1D member 2 (sprot)

description: A secretoglobin family 1D member 2 that is encoded in the genome of human.


name: LGI1_HUMAN Leucine-rich glioma-inactivated protein 1 (sprot)

description: A leucine-rich glioma-inactivated protein 1 that is encoded in the genome of human.


name: positive regulation of synaptic transmission

description: Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.


BY55_HUMAN CD160 antigen (sprot)

A CD160 molecule that is encoded in the genome of human.


MHC class I protein complex binding

description: Binding to a class I major histocompatibility complex.


MHC class I receptor activity

description: Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.


MHC class Ib receptor activity

description: Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.


name: activating MHC class I receptor activity

description: Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte.


name: positive regulation of natural killer cell cytokine production

description: Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production.


name: positive regulation of natural killer cell mediated immune response to tumor cell

description: Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.


name: negative regulation of CD4-positive, alpha-beta T cell costimulation

description: Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation.


name: negative regulation of adaptive immune memory response

description: Any process that stops, prevents or reduces the frequency, rate or extent of adaptive immune memory response.


name: BMP15_HUMAN Bone morphogenetic protein 15 (sprot)

description: A bone morphogenetic protein 15 that is encoded in the genome of human.


name: IGSF6_HUMAN Immunoglobulin superfamily member 6 (sprot)

description: An immunoglobulin superfamily member 6 that is encoded in the genome of human.


name: S1PR4_HUMAN Sphingosine 1-phosphate receptor 4 (sprot)

description: A sphingosine 1-phosphate receptor 4 that is encoded in the genome of human.


name: RECK_HUMAN Reversion-inducing cysteine-rich protein with Kazal motifs (sprot)

description: A reversion-inducing cysteine-rich protein with Kazal motifs that is encoded in the genome of human.


metalloendopeptidase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.


name: regulation of establishment of blood-brain barrier

description: Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain.


name: negative regulation of metalloendopeptidase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity.


name: MBD3_HUMAN Methyl-CpG-binding domain protein 3 (sprot)

description: A methyl-CpG-binding domain protein 3 that is encoded in the genome of human.


name: TOP3B_HUMAN DNA topoisomerase 3-beta-1 (sprot)

description: A DNA topoisomerase 3-beta-1 that is encoded in the genome of human.


DNA topoisomerase activity

description: Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.


DNA topological change

description: The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.


name: DNA topoisomerase III-beta-TDRD3 complex

description: A protein complex that has DNA topoisomerase type I and RNA topoisomerase activities.


name: TCL1B_HUMAN T-cell leukemia/lymphoma protein 1B (sprot)

description: A T-cell leukemia/lymphoma protein 1B that is encoded in the genome of human.


name: NUDT3_HUMAN Diphosphoinositol polyphosphate phosphohydrolase 1 (sprot)

description: A diphosphoinositol polyphosphate phosphohydrolase 1 that is encoded in the genome of human.


endopolyphosphatase activity

description: Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues.


description: Catalysis of the reaction: diphospho-1D-myo-inositol polyphosphate + H2O = 1D-myo-inositol polyphosphate + phosphate.


name: inositol diphosphate tetrakisphosphate diphosphatase activity

description: Catalysis of the reaction: diphospho-1D-myo-inositol tetrakisphosphate + H2O = 1D-myo-inositol pentakisphosphate + phosphate.


name: inositol diphosphate pentakisphosphate diphosphatase activity

description: Catalysis of the reaction: diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate.


description: Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + H+.


description: Catalysis of the reaction: 3,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H+.


name: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity

description: Catalysis of the reaction: a 5'-end (N2,N2,N7-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H+ + N7-methyl-GMP. Can also use (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA as a substrate.


name: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity

description: Catalysis of the reaction: a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + N7-methyl-GDP + H+.


name: diadenosine polyphosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached.


name: diphosphoinositol polyphosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached.


RNA decapping

description: Cleavage of the 5'-cap of an RNA.


name: diadenosine hexaphosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of diadenosine hexaphosphate.


name: F107A_HUMAN Actin-associated protein FAM107A (sprot)

description: An actin-associated protein FAM107A that is encoded in the genome of human.


name: CH25H_HUMAN Cholesterol 25-hydroxylase (sprot)

description: A cholesterol 25-hydroxylase that is encoded in the genome of human.


cholesterol 25-hydroxylase activity

description: Catalysis of the reaction: AH(2) + cholesterol + O2 = 25-hydroxycholesterol + A + H2O.


response to type I interferon

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


name: negative regulation of cholesterol metabolic process

description: Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


name: negative regulation of fusion of virus membrane with host plasma membrane

description: Any process that stops, prevents or reduces the frequency, rate or extent of fusion of virus membrane with host plasma membrane.


name: AGR2_HUMAN Anterior gradient protein 2 homolog (sprot)

description: An anterior gradient protein 2 that is encoded in the genome of human.


name: positive regulation of developmental growth

description: Any process that activates, maintains or increases the rate of developmental growth.


name: positive regulation of PERK-mediated unfolded protein response

description: Any process that activates or increases the frequency, rate or extent of the PERK-mediated unfolded protein response.


name: DRC4_HUMAN Dynein regulatory complex subunit 4 (sprot)

description: A dynein regulatory complex subunit 4 that is encoded in the genome of human.


name: cilium movement involved in cell motility

description: Movement of cilia mediated by motor proteins that contributes to the movement of a cell.


name: positive regulation of protein localization to cilium

description: Any process that activates or increases the frequency, rate or extent of protein localization to cilium.


regulation of microtubule binding

description: Any process that modulates the frequency, rate or extent of microtubule binding.


name: APCL_HUMAN Adenomatous polyposis coli protein 2 (sprot)

description: An adenomatous polyposis coli protein 2 that is encoded in the genome of human.


lamellipodium membrane

description: The portion of the plasma membrane surrounding a lamellipodium.


PTTG1_HUMAN Securin (sprot)

A securin that is encoded in the genome of human.


name: I18BP_HUMAN Interleukin-18-binding protein (sprot)

description: An interleukin-18-binding protein that is encoded in the genome of human.


interleukin-18 binding

description: Binding to interleukin-18.


name: BCL10_HUMAN B-cell lymphoma/leukemia 10 (sprot)

description: A B-cell lymphoma/leukemia 10 that is encoded in the genome of human.


name: positive regulation of lymphotoxin A production

description: Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production.


name: positive regulation of mast cell cytokine production

description: Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production.


kinase activator activity

description: Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


protein kinase B binding

description: Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism.


name: general transcription initiation factor binding

description: Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation.


name: negative regulation of mature B cell apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process.


immunoglobulin mediated immune response

description: An immune response mediated by immunoglobulins, whether cell-bound or in solution.


response to food

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat.


T cell apoptotic process

description: Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.


polkadots

description: A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals.


CBM complex

description: A protein complex comprising Bcl10, MALT1 and a CARD domain-containing protein (CARD9, CARD10 or CARD11); plays a role in signal transduction during NF-kappaB activation.


name: NDUBA_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 that is encoded in the genome of human.


name: PPR17_HUMAN Protein phosphatase 1 regulatory subunit 17 (sprot)

description: A protein phosphatase 1 regulatory subunit 17 that is encoded in the genome of human.


regulation of phosphatase activity

description: Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing phosphate.


name: CX001_HUMAN Putative transmembrane protein CXorf1 (sprot)


name: HAND1_HUMAN Heart- and neural crest derivatives-expressed protein 1 (sprot)

description: A heart- and neural crest derivatives-expressed protein 1 that is encoded in the genome of human.


embryonic heart tube formation

description: The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.


cardiac left ventricle formation

description: The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts.


cardiac right ventricle formation

description: The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts.


mesenchyme development

description: The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells.


name: CLPT1_HUMAN Putative lipid scramblase CLPTM1 (sprot)

description: A putative lipid scramblase CLPTM1 that is encoded in the genome of human.


name: regulation of T cell differentiation in thymus

description: Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus.


name: ZBED1_HUMAN E3 SUMO-protein ligase ZBED1 (sprot)

description: An E3 SUMO-protein ligase ZBED1 that is encoded in the genome of human.


protein autosumoylation

description: The sumoylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.


name: MOC2B_HUMAN Molybdopterin synthase catalytic subunit (sprot)

description: A molybdopterin synthase catalytic subunit that is encoded in the genome of human.


molybdopterin synthase activity

description: Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis.


name: molybdopterin cofactor biosynthetic process

description: The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.


molybdopterin synthase complex

description: A heterotetrameric protein complex that catalyses sulfur transfer from the sulfur carrier subunit of molybdopterin synthase to precursor Z to synthesize molybdopterin as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoaE and MoaD; in human, MOCS2B and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved.


name: TOM40_HUMAN Mitochondrial import receptor subunit TOM40 homolog (sprot)

description: A mitochondrial import receptor subunit TOM40 that is encoded in the genome of human.


porin activity

description: Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.


NAPSA_HUMAN Napsin-A (sprot)

A napsin-A that is encoded in the genome of human.


aspartic-type endopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.


membrane protein proteolysis

description: The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.


surfactant homeostasis

description: Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid.


alveolar lamellar body

description: A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.


multivesicular body lumen

description: The volume enclosed by the outermost membrane of a multivesicular body.


name: PX11B_HUMAN Peroxisomal membrane protein 11B (sprot)

description: A peroxisomal membrane protein 11B that is encoded in the genome of human.


name: PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (sprot)

description: A serine/threonine-protein kinase PAK 4 that is encoded in the genome of human.


WNT11_HUMAN Protein Wnt-11 (sprot)

A protein Wnt-11 that is encoded in the genome of human.


primary heart field specification

description: The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.


name: planar cell polarity pathway involved in axis elongation

description: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation.


name: Wnt signaling pathway, calcium modulating pathway

description: A type of non-canonical Wnt signaling in which Wnt binding to its receptor on the surface of a target cell leads to an increase in intracellular calcium and activation of protein kinase C (PKC).


adrenal gland development

description: The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.


name: positive regulation of transforming growth factor beta2 production

description: Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2.


paraxial mesoderm formation

description: The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.


notochord morphogenesis

description: The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.


name: convergent extension involved in axis elongation

description: The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.


cloacal septation

description: The separation of the single opening of the digestive, urinary, and reproductive tracts, the cloaca, into multiple isolated openings during development.


lung-associated mesenchyme development

description: The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung.


ureteric bud morphogenesis

description: The process in which the ureteric bud is generated and organized.


name: planar cell polarity pathway involved in gastrula mediolateral intercalation

description: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) contributing to the interdigitation of cells along the mediolateral axis during gastrulation.


name: negative regulation of cartilage development

description: Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


mesonephric duct development

description: The process whose specific outcome is the progression of a mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct is a tube drains the mesonephros.


name: positive regulation of protein kinase C signaling

description: Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.


name: negative regulation of fibroblast growth factor production

description: Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


name: DNAL4_HUMAN Dynein axonemal light chain 4 (sprot)

description: A dynein axonemal light chain 4 that is encoded in the genome of human.


microtubule-based movement

description: A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.