name: positive regulation of anterograde dense core granule transport

description: Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport.


name: regulation of organelle transport along microtubule

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that modulates the frequency, rate or extent of organelle transport along microtubule.


name: positive regulation of anterograde synaptic vesicle transport

description: Any process that activates or increases the frequency, rate or extent of anterograde synaptic vesicle transport.


name: negative regulation of microtubule binding

description: Any process that stops, prevents or reduces the frequency, rate or extent of microtubule binding.


dendritic branch

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A dendrite arising from another dendrite.


primary dendrite

description: A dendrite emerging from the cell body (the soma) of a neuron.


distal dendrite

description: The dendrite of the dendritic tree that is farthest away from the neuronal cell body (the soma).


apical distal dendrite

description: Any dendrite in a dendritic tree that emerges near the apical pole of a neuron, and which is farthest away from the neuronal cell body (the soma).


dendritic filopodium

description: A small, membranous protrusion found primarily on dendritic stretches of developing neurons. May receive synaptic input, and can develop into dendritic spines.


proximal dendrite

description: The dendrite of the dendritic tree that is closest to the neuronal cell body (the soma).


name: HSP7C_HUMAN Heat shock cognate 71 kDa protein (sprot)

description: A heat shock cognate 71 kDa protein that is encoded in the genome of human.


A1 adenosine receptor binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to an A1 adenosine receptor.


prostaglandin binding

description: Binding to prostaglandin.


clathrin-uncoating ATPase activity

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP.


name: protein transmembrane import into intracellular organelle

description: The directed movement of proteins into an intracellular organelle, across a membrane.


name: positive regulation by host of viral genome replication

description: A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication.


name: positive regulation of lysosomal membrane permeability

description: Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane.


name: negative regulation of supramolecular fiber organization

description: Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization.


regulation of protein import

description: Any process that modulates the frequency, rate or extent of protein import.


name: positive regulation of protein refolding

description: Any process that activates or increases the frequency, rate or extent of protein refolding.


name: chaperone-mediated autophagy translocation complex disassembly

description: The disaggregation of a chaperone-mediated autophagy translocation complex into its constituent components.


slow axonal transport

description: The directed slow movement of non-membranous molecules in nerve cell axons. It is comprised of a Slow Component a (SCa) and a Slow Component b (SCb) which differ in transport rates and protein composition.


name: clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

description: The lipid bilayer surrounding a clathrin-sculpted gamma-aminobutyric acid transport vesicle.


photoreceptor ribbon synapse

description: A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon.


lysosomal matrix

description: A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome.


name: LIPC_HUMAN Hepatic triacylglycerol lipase (sprot)

description: A hepatic triacylglycerol lipase that is encoded in the genome of human.


name: intermediate-density lipoprotein particle remodeling

description: The acquisition, loss or modification of a protein or lipid within an intermediate-density lipoprotein particle.


name: EGR2_HUMAN E3 SUMO-protein ligase EGR2 (sprot)

description: An early growth response protein 2 that is encoded in the genome of human.


rhythmic behavior

description: The specific behavior of an organism that recur with measured regularity.


Schwann cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.


name: positive regulation of Schwann cell differentiation

description: Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation.


rhombomere 3 structural organization

description: The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.


rhombomere 3 formation

description: The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


rhombomere 5 structural organization

description: The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.


rhombomere 5 formation

description: The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


name: GTR1_HUMAN Solute carrier family 2, facilitated glucose transporter member 1 (sprot)

description: A solute carrier family 2, facilitated glucose transporter member 1 that is encoded in the genome of human.


name: long-chain fatty acid import across plasma membrane

description: The directed movement of a long-chain fatty acid from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


L-ascorbic acid metabolic process

description: The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.


name: response to Thyroglobulin triiodothyronine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus.


glucose transporter complex

description: A protein complex facilitating glucose transport into, out of or within a cell, or between cells.


name: GTR2_HUMAN Solute carrier family 2, facilitated glucose transporter member 2 (sprot)

description: A solute carrier family 2, facilitated glucose transporter member 2 that is encoded in the genome of human.


name: fructose transmembrane transporter activity

description: Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.


name: galactose transmembrane transporter activity

description: Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.


name: hexose transmembrane transporter activity

description: Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other.


name: GTR3_HUMAN Solute carrier family 2, facilitated glucose transporter member 3 (sprot)

description: A solute carrier family 2, facilitated glucose transporter member 3 that is encoded in the genome of human.


EPB41_HUMAN Protein 4.1 (sprot)

A protein 4.1 that is encoded in the genome of human.


regulation of intestinal absorption

description: Any process that modulates the frequency, rate or extent of intestinal absorption.


name: UMPS_HUMAN Uridine 5'-monophosphate synthase (sprot)

description: A uridine 5'-monophosphate synthase that is encoded in the genome of human.


description: Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.


description: Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP.


name: 'de novo' pyrimidine nucleobase biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.


UMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate.


UDP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate.


'de novo' UMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD+ or oxygen.


name: ODPB_HUMAN Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (sprot)

description: A pyruvate dehydrogenase E1 component subunit beta, mitochondrial that is encoded in the genome of human.


name: ODB2_HUMAN Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (sprot)

description: A lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial that is encoded in the genome of human.


description: Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine.


ITAM_HUMAN Integrin alpha-M (sprot)

An integrin alpha-M that is encoded in the genome of human.


ectodermal cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate.


response to curcumin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus.


name: PYGB_HUMAN Glycogen phosphorylase, brain form (sprot)

description: A glycogen phosphorylase, brain form that is encoded in the genome of human.


name: PYGM_HUMAN Glycogen phosphorylase, muscle form (sprot)

description: A glycogen phosphorylase, muscle form that is encoded in the genome of human.


name: MBL2_HUMAN Mannose-binding protein C (sprot)

description: A mannose-binding protein C that is encoded in the genome of human.


name: ACM1_HUMAN Muscarinic acetylcholine receptor M1 (sprot)

description: A muscarinic acetylcholine receptor M1 that is encoded in the genome of human.


name: positive regulation of monoatomic ion transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


regulation of glial cell proliferation

description: Any process that modulates the frequency, rate or extent of glial cell proliferation.


name: ACHB_HUMAN Acetylcholine receptor subunit beta (sprot)

description: An acetylcholine receptor subunit beta that is encoded in the genome of human.


postsynaptic membrane organization

description: A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).


behavioral response to nicotine

description: Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.


name: RALA_HUMAN Ras-related protein Ral-A (sprot)

description: A Ras-related protein Ral-A that is encoded in the genome of human.


name: Edg-2 lysophosphatidic acid receptor binding

description: Binding to an Edg-2 lysophosphatidic acid receptor.


membrane raft localization

description: Any process in which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.


name: establishment of protein localization to mitochondrion

description: The directed movement of a protein to the mitochondrion or a part of the mitochondrion.


name: RALB_HUMAN Ras-related protein Ral-B (sprot)

description: A Ras-related protein Ral-B that is encoded in the genome of human.


regulation of exocyst assembly

description: Any process that modulates the frequency, rate or extent of exocyst assembly.


regulation of exocyst localization

description: Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.


name: ARY2_HUMAN Arylamine N-acetyltransferase 2 (sprot)

description: An arylamine N-acetyltransferase 2 that is encoded in the genome of human.


arylamine N-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.


description: Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine.


name: BCR_HUMAN Breakpoint cluster region protein (sprot)

description: A breakpoint cluster region protein that is encoded in the genome of human.


name: negative regulation of cellular extravasation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation.


name: negative regulation of neutrophil degranulation

description: Any process that stops, prevents, or reduces the rate of neutrophil degranulation.


name: negative regulation of respiratory burst

description: Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.


macrophage migration

description: The orderly movement of a macrophage from one site to another.


name: negative regulation of macrophage migration

description: Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration.


name: SPTB1_HUMAN Spectrin beta chain, erythrocytic (sprot)

description: A spectrin beta chain, erythrocytic that is encoded in the genome of human.


name: LAMP1_HUMAN Lysosome-associated membrane glycoprotein 1 (sprot)

description: A lysosome-associated membrane glycoprotein 1 that is encoded in the genome of human.


name: establishment of protein localization to organelle

description: The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.


phagolysosome membrane

description: The lipid bilayer surrounding a phagolysosome.


cytolytic granule membrane

description: The lipid bilayer surrounding the cytolytic granule.


name: ERG_HUMAN Transcriptional regulator ERG (sprot)

description: A transcriptional regulator ERG that is encoded in the genome of human.


name: PIM1_HUMAN Serine/threonine-protein kinase pim-1 (sprot)

description: A proto-oncogene serine/threonine-protein kinase Pim-1 that is encoded in the genome of human.


vitamin D receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A nuclear receptor-mediated signaling pathway initiated by vitamin D binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


name: regulation of hematopoietic stem cell proliferation

description: Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation.


name: positive regulation of cardioblast proliferation

description: Any process that activates or increases the frequency, rate or extent of cardioblast proliferation.


name: ACADM_HUMAN Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (sprot)

description: A medium-chain specific acyl-CoA dehydrogenase, mitochondrial that is encoded in the genome of human.


acyl-CoA dehydrogenase activity

description: Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].


name: medium-chain fatty acyl-CoA dehydrogenase activity

description: Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.


carnitine metabolic process, CoA-linked

description: The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA.


name: fatty acid beta-oxidation using acyl-CoA dehydrogenase

description: A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).


name: medium-chain fatty acid metabolic process

description: The chemical reactions and pathways involving a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.


name: medium-chain fatty acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.


name: FGFR1_HUMAN Fibroblast growth factor receptor 1 (sprot)

description: A fibroblast growth factor receptor 1 that is encoded in the genome of human.


name: fibroblast growth factor receptor activity

description: Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.


regulation of phosphate transport

description: Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


ventricular zone neuroblast division

description: The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially.


name: fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development

description: The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state.


chordate embryonic development

description: The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.


phosphatidylinositol-mediated signaling

description: The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.


name: regulation of lateral mesodermal cell fate specification

description: Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate specification.


auditory receptor cell development

description: The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.


vitamin D3 metabolic process

description: The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol.


diphosphate metabolic process

description: The chemical reactions and pathways involving diphosphate, the anion or salt of diphosphoric acid.


name: positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

description: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade.


name: positive regulation of mitotic cell cycle DNA replication

description: Any process that activates or increases the frequency, rate or extent of mitotic cell cycle DNA replication.


name: positive regulation of parathyroid hormone secretion

description: Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion.


name: regulation of extrinsic apoptotic signaling pathway in absence of ligand

description: Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.


TOP1_HUMAN DNA topoisomerase 1 (sprot)

A type 1B DNA topoisomerase 1 that is encoded in the genome of human.


name: DNA topoisomerase type I (single strand cut, ATP-independent) activity

description: Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.


embryonic cleavage

description: The first few specialized divisions of an activated animal egg.


name: TOP2A_HUMAN DNA topoisomerase 2-alpha (sprot)

description: A DNA topoisomerase 2-alpha that is encoded in the genome of human.


name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

description: Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.


DNA ligation

description: The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.


name: positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

description: Any process that activates or increases the frequency, rate or extent of retroviral genome replication.


name: negative regulation of DNA duplex unwinding

description: Any process that stops, prevents or reduces the frequency, rate or extent of DNA duplex unwinding.


name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

description: Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity.


name: G6PD_HUMAN Glucose-6-phosphate 1-dehydrogenase (sprot)

description: A glucose-6-phosphate 1-dehydrogenase that is encoded in the genome of human.


NADP metabolic process

description: The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.


pentose biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule.


ribose phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar.


name: positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

description: Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel.


name: UBL4A_HUMAN Ubiquitin-like protein 4A (sprot)

description: A ubiquitin-like protein 4A that is encoded in the genome of human.


name: ubiquitin-like protein transferase activity

description: Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.


name: post-translational protein targeting to endoplasmic reticulum membrane

description: The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.


BAT3 complex

description: A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A.


name: PSG1_HUMAN Pregnancy-specific beta-1-glycoprotein 1 (sprot)

description: A pregnancy-specific beta-1-glycoprotein 1 that is encoded in the genome of human.


name: PSG2_HUMAN Pregnancy-specific beta-1-glycoprotein 2 (sprot)

description: A pregnancy-specific beta-1-glycoprotein 2 that is encoded in the genome of human.


VDR_HUMAN Vitamin D3 receptor (sprot)

A vitamin D3 receptor that is encoded in the genome of human.


vitamin D response element binding

description: Binding to a vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum.


bile acid nuclear receptor activity

description: A DNA-binding transcription factor activity regulated by binding to a bile acid that modulates the transcription of specific gene sets transcribed by RNA polymerase II.


calcitriol binding

description: Binding to calcitriol. Calcitriol (1,25-dihydroxycholecalciferol) is the hormonally active form of vitamin D3.


lithocholic acid binding

description: Binding to lithocholic acid.


name: apoptotic process involved in mammary gland involution

description: Any apoptotic process that triggers the activity of proteolytic caspases whose actions dismantle the mammary epithelial cells resulting in their programmed cell death.


name: positive regulation of apoptotic process involved in mammary gland involution

description: Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process of mammary epithelial cells during mammary gland involution.


name: regulation of calcidiol 1-monooxygenase activity

description: Any process that modulates the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.


response to bile acid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.


name: ERR1_HUMAN Steroid hormone receptor ERR1 (sprot)

description: A steroid hormone receptor ERR1 that is encoded in the genome of human.


name: FGF3_HUMAN Fibroblast growth factor 3 (sprot)

description: A fibroblast growth factor 3 that is encoded in the genome of human.


name: negative regulation of cardiac muscle tissue development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development.


name: GNAT1_HUMAN Guanine nucleotide-binding protein G(t) subunit alpha-1 (sprot)

description: A guanine nucleotide-binding protein G(t) subunit alpha-1 that is encoded in the genome of human.


acyl binding

description: Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid.


retinal cone cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell.


name: negative regulation of cyclic-nucleotide phosphodiesterase activity

description: Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.


retinal rod cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell.


neural tissue regeneration

description: The regrowth of neural tissue following its loss or destruction.


background adaptation

description: Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity.


name: PYC_HUMAN Pyruvate carboxylase, mitochondrial (sprot)

description: A pyruvate carboxylase, mitochondrial that is encoded in the genome of human.


pyruvate carboxylase activity

description: Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H+ + oxaloacetate + phosphate.


NADH metabolic process

description: The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.


viral RNA genome packaging

description: The packaging of viral RNA (single-stranded or double-stranded) into a nucleocapsid.


CP2A6_HUMAN Cytochrome P450 2A6 (sprot)

A cytochrome P450 2A that is a translation product of the CYP2A6 gene in human.


coumarin 7-hydroxylase activity

description: Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+.


coumarin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids.


CP19A_HUMAN Aromatase (sprot)

An aromatase that is encoded in the genome of human.


name: negative regulation of chronic inflammatory response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response.


testosterone biosynthetic process

description: The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5.


DMD_HUMAN Dystrophin (sprot)

A dystrophin that is encoded in the genome of human.


name: regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion

description: Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.


name: regulation of skeletal muscle contraction

description: Any process that modulates the frequency, rate or extent of skeletal muscle contraction.


cardiac muscle cell action potential

description: An action potential that occurs in a cardiac muscle cell.


name: negative regulation of peptidyl-cysteine S-nitrosylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.


name: positive regulation of sodium ion transmembrane transporter activity

description: Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity.


cell-substrate junction

description: A cell junction that forms a connection between a cell and the extracellular matrix.


syntrophin complex

description: A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase.


name: C1TC_HUMAN C-1-tetrahydrofolate synthase, cytoplasmic (sprot)

description: A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of human.


description: Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.


description: Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.


name: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+.


name: methylenetetrahydrofolate dehydrogenase (NAD+) activity

description: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH.


name: methylenetetrahydrofolate dehydrogenase (NADP+) activity

description: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH.


methionine metabolic process

description: The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.


name: serine family amino acid metabolic process

description: The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.


name: serine family amino acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.


methionine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.


name: purine ribonucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


description: The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.


transsulfuration

description: The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes.


name: CETP_HUMAN Cholesteryl ester transfer protein (sprot)

description: A cholesteryl ester transfer protein that is encoded in the genome of human.


name: positive regulation of cholesterol transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: PERE_HUMAN Eosinophil peroxidase (sprot)

description: An eosinophil peroxidase that is encoded in the genome of human.


defense response to nematode

description: A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.


eosinophil migration

description: The movement of an eosinophil within or between different tissues and organs of the body.


UTER_HUMAN Uteroglobin (sprot)

A uteroglobin that is encoded in the genome of human.


polychlorinated biphenyl binding

description: Binding to a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings.


name: negative regulation of interleukin-4 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.


PSPC_HUMAN Surfactant protein C (sprot)

A pulmonary surfactant-associated protein C that is encoded in the genome of human.


CP2C9_HUMAN Cytochrome P450 2C9 (sprot)

A cytochrome P450 2C9 that is encoded in the genome of human.


name: arachidonic acid 14,15-epoxygenase activity

description: Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid.


name: arachidonic acid 11,12-epoxygenase activity

description: Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid.


(S)-limonene 6-monooxygenase activity

description: Catalysis of the reaction: (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


(S)-limonene 7-monooxygenase activity

description: Catalysis of the reaction: (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


(R)-limonene 6-monooxygenase activity

description: Catalysis of the reaction: (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


urea metabolic process

description: The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2.


amide metabolic process

description: The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.


name: MPRI_HUMAN Cation-independent mannose-6-phosphate receptor (sprot)

description: A cation-independent mannose-6-phosphate receptor that is encoded in the genome of human.


response to tetrachloromethane

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrachloromethane stimulus.


name: ADHX_HUMAN Alcohol dehydrogenase class-3 (sprot)

description: An alcohol dehydrogenase class-3 that is encoded in the genome of human.


formaldehyde dehydrogenase activity

description: Catalysis of the reaction: formaldehyde + H2O + NAD+ = formate + 2 H+ + NADH.


name: S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity

description: Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.


name: S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity

description: Catalysis of the reaction: S-(hydroxymethyl)glutathione + NADP+ = S-formylglutathione + NADPH + H+.


name: S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity

description: Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD+ = S-formylglutathione + NADH + H+.


response to nitrosative stress

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.


name: KPSH1_HUMAN Serine/threonine-protein kinase H1 (sprot)

description: A serine/threonine-protein kinase H1 that is encoded in the genome of human.


name: CDK4_HUMAN Cyclin-dependent kinase 4 (sprot)

description: A cell division protein kinase 4 that is encoded in the genome of human.


name: cyclin-dependent protein serine/threonine kinase regulator activity

description: Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.


name: regulation of type B pancreatic cell proliferation

description: Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation.


cellular response to ionomycin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus.


cyclin D1-CDK4 complex

description: A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


cyclin D2-CDK4 complex

description: A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


cyclin D3-CDK4 complex

description: A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


SRF_HUMAN Serum response factor (sprot)

A serum response factor that is encoded in the genome of human.


serum response element binding

description: Binding to a serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum.


primary miRNA binding

description: Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding.


morphogenesis of an epithelial sheet

description: The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.


name: tangential migration from the subventricular zone to the olfactory bulb

description: The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.


dorsal aorta morphogenesis

description: The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.


name: positive regulation of transcription by glucose

description: Any process involving glucose that activates or increases the rate of transcription.


name: regulation of smooth muscle cell differentiation

description: Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation.


bronchus cartilage development

description: The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


name: cardiac vascular smooth muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers.


lung smooth muscle development

description: The process whose specific outcome is the progression of smooth muscle in the lung over time, from its formation to the mature structure.


epithelial cell-cell adhesion

description: The attachment of an epithelial cell to another epithelial cell via adhesion molecules.


name: CD20_HUMAN B-lymphocyte antigen CD20 (sprot)

description: A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of human.


store-operated calcium entry

description: A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.


calcium ion import into cytosol

description: The directed movement of calcium ion into a cytosol.


CRGA_HUMAN Gamma-crystallin A (sprot)

A gamma-crystallin A that is encoded in the genome of human.


name: PRPS2_HUMAN Ribose-phosphate pyrophosphokinase 2 (sprot)

description: A ribose-phosphate pyrophosphokinase 2 that is encoded in the genome of human.


name: ribose phosphate diphosphokinase activity

description: Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+.


name: ribonucleoside monophosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.


name: CD79A_HUMAN B-cell antigen receptor complex-associated protein alpha chain (sprot)

description: A B-cell antigen receptor complex-associated protein alpha chain that is encoded in the genome of human.


B cell receptor complex

description: An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.


IgM B cell receptor complex

description: An IgM immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.


name: DCOR_HUMAN Ornithine decarboxylase (sprot)

description: An ornithine decarboxylase that is encoded in the genome of human.


ornithine decarboxylase activity

description: Catalysis of the reaction: L-ornithine + H+ = CO2 + putrescine.


name: putrescine biosynthetic process from ornithine

description: The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine.


name: PABP1_HUMAN Polyadenylate-binding protein 1 (sprot)

description: A polyadenylate-binding protein 1 that is encoded in the genome of human.


translation activator activity

description: Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide.


name: PCNA_HUMAN Proliferating cell nuclear antigen (sprot)

description: A proliferating cell nuclear antigen that is encoded in the genome of human.


name: purine-specific mismatch base pair DNA N-glycosylase activity

description: Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.


name: dinucleotide insertion or deletion binding

description: Binding to a double-stranded DNA region containing a dinucleotide insertion or deletion.


MutLalpha complex binding

description: Binding to a MutLalpha mismatch repair complex.


translesion synthesis

description: The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.


name: positive regulation of deoxyribonuclease activity

description: Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.


name: mitotic telomere maintenance via semi-conservative replication

description: Any telomere maintenance via semi-conservative replication that is involved in mitotic cell cycle.


PCNA complex

description: A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.


replisome

description: A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.


PCNA-p21 complex

description: A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication.


name: VPREB_HUMAN Immunoglobulin iota chain (sprot)

description: An immunoglobulin iota chain that is encoded in the genome of human.


name: FGF5_HUMAN Fibroblast growth factor 5 (sprot)

description: A fibroblast growth factor 5 that is encoded in the genome of human.


name: K2C3_HUMAN Keratin, type II cytoskeletal 3 (sprot)

description: A keratin, type II cytoskeletal 3 that is encoded in the genome of human.


name: NFH_HUMAN Neurofilament heavy polypeptide (sprot)

description: A neurofilament heavy polypeptide that is encoded in the genome of human.


name: peripheral nervous system neuron axonogenesis

description: Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells.


name: postsynaptic intermediate filament cytoskeleton

description: The intermediate filament cytoskeleton that is part of a postsynapse.


name: CX6A1_HUMAN Cytochrome c oxidase subunit 6A1, mitochondrial (sprot)

description: A cytochrome c oxidase subunit 6A1, mitochondrial that is encoded in the genome of human.


name: HARS1_HUMAN Histidine--tRNA ligase, cytoplasmic (sprot)

description: A histidyl-tRNA synthetase, cytoplasmic that is encoded in the genome of human.


histidine-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).


histidyl-tRNA aminoacylation

description: The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.


name: FABPI_HUMAN Fatty acid-binding protein, intestinal (sprot)

description: A fatty acid-binding protein, intestinal that is encoded in the genome of human.


intestinal lipid absorption

description: A process in which lipids are taken up from the contents of the intestine.


name: COBA1_HUMAN Collagen alpha-1(XI) chain (sprot)

description: A collagen alpha-1(XI) chain that is encoded in the genome of human.


tendon development

description: The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force.


name: CO6A1_HUMAN Collagen alpha-1(VI) chain (sprot)

description: A collagen alpha-1(VI) chain that is encoded in the genome of human.


name: reduction of food intake in response to dietary excess

description: An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients.


muscle cell apoptotic process

description: A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle.


apoptotic nuclear changes

description: Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.


response to decreased oxygen levels

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.


lung epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung.


fat cell proliferation

description: The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat.


caveola assembly

description: The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane.


multicellular organismal locomotion

description: Locomotion in a multicellular organism, i.e. self-propelled movement of a multicellular organism from one location to another.


response to peptide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.


response to polyamine macromolecule

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus.


response to bleomycin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus.


mitochondrial transmembrane transport

description: The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion.


collagen type VI trimer

description: A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils.


name: CO6A2_HUMAN Collagen alpha-2(VI) chain (sprot)

description: A collagen alpha-2(VI) chain that is encoded in the genome of human.


name: CO6A3_HUMAN Collagen alpha-3(VI) chain (sprot)

description: A collagen alpha-3(VI) chain that is encoded in the genome of human.


name: ADT1_HUMAN ADP/ATP translocase 1 (sprot)

description: An ADP/ATP translocase 1 that is encoded in the genome of human.


name: ADT3_HUMAN ADP/ATP translocase 3 (sprot)

description: An ADP/ATP translocase 3 that is encoded in the genome of human.


FA5_HUMAN Coagulation factor V (sprot)

A coagulation factor V that is encoded in the genome of human.


name: IMDH2_HUMAN Inosine-5'-monophosphate dehydrogenase 2 (sprot)

description: An inosine-5'-monophosphate dehydrogenase 2 that is encoded in the genome of human.


IMP dehydrogenase activity

description: Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.


TPR_HUMAN Nucleoprotein TPR (sprot)

A nucleoprotein TPR that is encoded in the genome of human.


nuclear pore organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore.


regulation of mRNA export from nucleus

description: Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm.


nuclear pore complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex.


structural constituent of nuclear pore

description: The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.


name: regulation of mitotic sister chromatid separation

description: Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis.


name: positive regulation of heterochromatin formation

description: Any process that activates or increases the frequency, rate or extent of heterochromatin formation.


name: mRNA export from nucleus in response to heat stress

description: The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export.


name: negative regulation of RNA export from nucleus

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm.


response to epidermal growth factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.


name: RLBP1_HUMAN Retinaldehyde-binding protein 1 (sprot)

description: A retinaldehyde-binding protein 1 that is encoded in the genome of human.


name: PTHR_HUMAN Parathyroid hormone-related protein (sprot)

description: A parathyroid hormone-related protein that is encoded in the genome of human.


name: negative regulation of chondrocyte development

description: Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.


name: PIP_HUMAN Prolactin-inducible protein (sprot)

description: A prolactin-inducible protein that is encoded in the genome of human.


name: KCRB_HUMAN Creatine kinase B-type (sprot)

description: A creatine kinase B-type that is encoded in the genome of human.


name: FCGR1_HUMAN High affinity immunoglobulin gamma Fc receptor I (sprot)

description: A high affinity immunoglobulin gamma Fc receptor I that is encoded in the genome of human.


high-affinity IgG receptor activity

description: Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: positive regulation of type III hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response.


name: FCG2A_HUMAN Low affinity immunoglobulin gamma Fc region receptor II-a (sprot)

description: A low affinity immunoglobulin gamma Fc region receptor II-a that is encoded in the genome of human.


name: FCERA_HUMAN High affinity immunoglobulin epsilon receptor subunit alpha (sprot)

description: A high affinity immunoglobulin epsilon receptor subunit alpha that is encoded in the genome of human.


high-affinity IgE receptor activity

description: Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


type I hypersensitivity

description: An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.


ANXA3_HUMAN Annexin A3 (sprot)

An annexin A3 that is encoded in the genome of human.


MYCL_HUMAN Protein L-Myc (sprot)

A protein L-Myc that is encoded in the genome of human.


name: regulation of inner ear auditory receptor cell differentiation

description: Any process that modulates the frequency, rate or extent of auditory hair cell differentiation.


name: MYCP1_HUMAN Putative myc-like protein MYCLP1 (sprot)

description: A protein L-Myc-2 that is encoded in the genome of human.


name: KCRU_HUMAN Creatine kinase U-type, mitochondrial (sprot)

description: A creatine kinase U-type, mitochondrial that is encoded in the genome of human.


GRAA_HUMAN Granzyme A (sprot)

A granzyme A that is encoded in the genome of human.


name: negative regulation of endodeoxyribonuclease activity

description: Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.


cytotoxic T cell pyroptotic cell death

description: A pyroptotic cell death process that occurs in a cytotoxic T cell.


name: BMP2_HUMAN Bone morphogenetic protein 2 (sprot)

description: A bone morphogenetic protein 2 that is encoded in the genome of human.


aortic valve development

description: The progression of the aortic valve over time, from its formation to the mature structure.


cardiocyte differentiation

description: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.


phosphatase activator activity

description: Binds to and increases the activity of a phosphatase.


endodermal-mesodermal cell signaling

description: Any process that mediates the transfer of information from endodermal cells to mesodermal cells.


cardiac atrium formation

description: The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.


name: positive regulation of extracellular matrix constituent secretion

description: Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.


name: negative regulation of aldosterone biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.


ameloblast differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an ameloblast, a cylindrical epithelial cell in the innermost layer of the enamel organ.


name: regulation of odontogenesis of dentin-containing tooth

description: Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates.


mesenchymal cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.


name: negative regulation of calcium-independent cell-cell adhesion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion.


name: mesenchymal cell proliferation involved in ureteric bud development

description: The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureteric bud, that contributes to ureteric bud development.


name: negative regulation of cortisol biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process.


BMP receptor complex

description: A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits.


name: BMP4_HUMAN Bone morphogenetic protein 4 (sprot)

description: A bone morphogenetic protein 4 that is encoded in the genome of human.


muscular septum morphogenesis

description: The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.


bronchus development

description: The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs.


trachea development

description: The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches.


bud dilation involved in lung branching

description: The process in which a bud in the lung increases radially.


regulation of cell fate commitment

description: Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.


dorsal/ventral neural tube patterning

description: The process in which the neural tube is regionalized in the dorsoventral axis.


name: negative regulation of T cell differentiation in thymus

description: Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus.


tendon cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance.


deltoid tuberosity development

description: The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase.


name: intermediate mesodermal cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an intermediate mesoderm cell.


neuron fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.


name: positive regulation of cardiac muscle fiber development

description: Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development.


lens induction in camera-type eye

description: Signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens.


trachea formation

description: The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches.


name: branching involved in prostate gland morphogenesis

description: The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem.


mammary gland formation

description: The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme.


epithelial-mesenchymal cell signaling

description: Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted.


name: negative regulation of prostatic bud formation

description: Any process that decreases the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth.


name: positive regulation of branching involved in lung morphogenesis

description: Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.


glomerular capillary formation

description: The process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts.


name: negative regulation of glomerular mesangial cell proliferation

description: Any process that decreases the frequency, rate or extent of glomerular mesangial cell proliferation.


nephric duct formation

description: The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney.


ureter morphogenesis

description: The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder.


name: negative regulation of mesenchymal cell proliferation involved in ureter development

description: Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


name: negative regulation of glomerulus development

description: Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.


pericyte cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell.


name: positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

description: Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.


name: regulation of mesodermal cell differentiation

description: Any process that modulates the frequency, rate or extent of mesodermal cell differentiation.


name: negative regulation of metanephric S-shaped body morphogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric S-shaped body morphogenesis.


name: negative regulation of metanephric comma-shaped body morphogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric comma-shaped body morphogenesis.


name: BMP3_HUMAN Bone morphogenetic protein 3 (sprot)

description: A bone morphogenetic protein 3 that is encoded in the genome of human.


name: ODBA_HUMAN 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (sprot)

description: A 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial that is encoded in the genome of human.


name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity

description: Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2.


name: branched-chain alpha-ketoacid dehydrogenase complex

description: A multi-enzyme complex that catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: branched-chain alpha-ketoacid dehydrogenase (E1, a heterotetramer of two alpha and two beta subunits), dihydrolipoyl transacylase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.


name: ECP_HUMAN Eosinophil cationic protein (sprot)

description: An eosinophil cationic protein that is encoded in the genome of human.


SKI_HUMAN Ski oncogene (sprot)

A ski oncogene that is encoded in the genome of human.


name: negative regulation of Schwann cell proliferation

description: Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.


histone deacetylase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes.


myotube differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


SKIL_HUMAN Ski-like protein (sprot)

A ski-like protein that is encoded in the genome of human.


name: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

description: Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage.


ACTN1_HUMAN Alpha-actinin-1 (sprot)

An alpha-actinin-1 that is encoded in the genome of human.


platelet morphogenesis

description: Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.


fascia adherens

description: A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes.


name: ACE_HUMAN Angiotensin-converting enzyme (sprot)

description: An angiotensin-converting enzyme that is encoded in the genome of human.


peptidyl-dipeptidase activity

description: Catalysis of the release of C-terminal dipeptides from a polypeptide chain.


name: mitogen-activated protein kinase kinase binding

description: Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase.


bradykinin receptor binding

description: Binding to a bradykinin receptor.


name: antigen processing and presentation of peptide antigen via MHC class I

description: The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.


name: regulation of systemic arterial blood pressure by renin-angiotensin

description: The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.


mononuclear cell proliferation

description: The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.


name: regulation of angiotensin metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin.


cell proliferation in bone marrow

description: The multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow.


MYL4_HUMAN Myosin light chain 4 (sprot)

A myosin light chain 4 that is encoded in the genome of human.


CADH1_HUMAN Cadherin-1 (sprot)

A cadherin-1 that is encoded in the genome of human.


cellular response to lithium ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.


cellular response to indole-3-methanol

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus.


name: regulation of protein catabolic process at postsynapse, modulating synaptic transmission

description: Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.


DEF4_HUMAN Defensin alpha 4 (sprot)

A protein that is a translation product of the DEFA4 gene in human.


MOTI_HUMAN Promotilin (sprot)

A promotilin that is encoded in the genome of human.


motilin receptor binding

description: Binding to a motilin receptor.


MYH1_HUMAN Myosin-1 (sprot)

A myosin-1 that is encoded in the genome of human.


MYH7_HUMAN Myosin-7 (sprot)

A myosin-7 that is encoded in the genome of human.


transition between fast and slow fiber

description: The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation.


myosin filament

description: A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament.


name: SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (sprot)

description: A proto-oncogene tyrosine-protein kinase Src that is encoded in the genome of human.


connexin binding

description: Binding to a connexin, any of a group of related proteins that assemble to form gap junctions.


primary ovarian follicle growth

description: Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle).


name: positive regulation of glucose metabolic process

description: Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.


name: regulation of toll-like receptor 3 signaling pathway

description: Any process that modulates the frequency, rate, or extent of toll-like receptor 3 signaling pathway.


name: positive regulation of dephosphorylation

description: Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule.


entry of bacterium into host cell

description: The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.


response to mineralocorticoid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance.


regulation of cell projection assembly

description: Any process that modulates the rate, frequency, or extent of cell projection assembly.


name: positive regulation of non-membrane spanning protein tyrosine kinase activity

description: Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.


name: positive regulation of male germ cell proliferation

description: Any process that activates or increases the frequency, rate or extent of male germ cell proliferation.


name: positive regulation of ovarian follicle development

description: Any process that activates or increases the frequency, rate or extent of ovarian follicle development.


name: regulation of caveolin-mediated endocytosis

description: Any process that modulates the frequency, rate or extent of caveolin-mediated endocytosis.


PEPD_HUMAN Xaa-Pro dipeptidase (sprot)

An Xaa-Pro dipeptidase that is encoded in the genome of human.


metallocarboxypeptidase activity

description: Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


proline dipeptidase activity

description: Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal = L-proline + a standard alpha amino acid.


name: XRCC6_HUMAN X-ray repair cross-complementing protein 6 (sprot)

description: An X-ray repair cross-complementing protein 6 that is encoded in the genome of human.


DNA end binding

description: Binding to DNA ends exposed by the creation of double-strand breaks (DSBs).


name: positive regulation of lymphocyte differentiation

description: Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation.


name: regulation of smooth muscle cell proliferation

description: Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.


cellular response to X-ray

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).


Ku70:Ku80 complex

description: Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK.


name: DNA-dependent protein kinase-DNA ligase 4 complex

description: A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV.


nonhomologous end joining complex

description: A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends.


LYL1_HUMAN Protein lyl-1 (sprot)

A protein lyl-1 that is encoded in the genome of human.


name: XRCC5_HUMAN X-ray repair cross-complementing protein 5 (sprot)

description: An X-ray repair cross-complementing protein 5 that is encoded in the genome of human.


small-subunit processome assembly

description: The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome.


name: negative regulation of t-circle formation

description: Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation.


name: UNG_HUMAN Uracil-DNA glycosylase (sprot)

description: A uracil-DNA glycosylase that is encoded in the genome of human.


uracil DNA N-glycosylase activity

description: Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.


name: base-excision repair, AP site formation via deaminated base removal

description: A base-excision repair, AP site formation process occurring via excision of a deaminated base.


name: NR2C1_HUMAN Nuclear receptor subfamily 2 group C member 1 (sprot)

description: A nuclear receptor subfamily 2 group C member 1 that is encoded in the genome of human.


name: COX41_HUMAN Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (sprot)

description: A cytochrome c oxidase subunit 4 isoform 1, mitochondrial that is encoded in the genome of human.


name: IFM1_HUMAN Interferon-induced transmembrane protein 1 (sprot)

description: An interferon-induced transmembrane protein that is a translation product of the IFITM1 gene in human.


response to interferon-alpha

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.


name: HEM1_HUMAN 5-aminolevulinate synthase, non-specific, mitochondrial (sprot)

description: A 5-aminolevulinate synthase, non-specific, mitochondrial that is encoded in the genome of human.


5-aminolevulinate synthase activity

description: Catalysis of the reaction: glycine + H+ + succinyl-CoA = 5-aminolevulinate + CO2 + CoA.


name: GP1BB_HUMAN Platelet glycoprotein Ib beta chain (sprot)

description: A platelet glycoprotein Ib beta chain that is encoded in the genome of human.


IL7_HUMAN Interleukin-7 (sprot)

An interleukin-7 that is encoded in the genome of human.


interleukin-7 receptor binding

description: Binding to an interleukin-7 receptor.


description: The series of molecular signals initiated by interleukin-7 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: positive regulation of B cell differentiation

description: Any process that activates or increases the frequency, rate or extent of B cell differentiation.


name: CCL4_HUMAN C-C motif chemokine 4 (sprot)

description: A C-C motif chemokine 4 that is encoded in the genome of human.


name: GILT_HUMAN Gamma-interferon-inducible lysosomal thiol reductase (sprot)

description: A gamma-interferon-inducible lysosomal thiol reductase that is encoded in the genome of human.


name: oxidoreductase activity, acting on a sulfur group of donors

description: Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


name: oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide.


MYF5_HUMAN Myogenic factor 5 (sprot)

A myogenic factor 5 that is encoded in the genome of human.


name: HXD8_HUMAN Homeobox protein Hox-D8 (sprot)

description: A homeobox protein Hox-D8 that is encoded in the genome of human.


TDGF1_HUMAN Protein Cripto (sprot)

A protein Cripto that is encoded in the genome of human.


name: LAMP2_HUMAN Lysosome-associated membrane glycoprotein 2 (sprot)

description: A lysosome-associated membrane glycoprotein 2 that is encoded in the genome of human.


name: RINI_HUMAN Ribonuclease inhibitor (sprot)

description: A ribonuclease inhibitor that is encoded in the genome of human.


ribonuclease inhibitor activity

description: Binds to and stops, prevents or reduces the activity of ribonuclease.


name: BMP1_HUMAN Bone morphogenetic protein 1 (sprot)

description: A bone morphogenetic protein 1 that is encoded in the genome of human.


name: CY24A_HUMAN Cytochrome b-245 light chain (sprot)

description: A cytochrome b-245 light chain that is encoded in the genome of human.


smooth muscle hypertrophy

description: The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy.


cytochrome complex assembly

description: The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.


name: CCL2_HUMAN C-C motif chemokine 2 (sprot)

description: A C-C motif chemokine 2 that is encoded in the genome of human.


CCR2 chemokine receptor binding

description: Binding to a CCR2 chemokine receptor.


helper T cell extravasation

description: The migration of a helper T cell from the blood vessels into the surrounding tissue. A helper T-cell is an effector T cell that provides help in the form of secreted cytokines to other immune cells.


name: negative regulation of vascular endothelial cell proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation.


name: negative regulation of natural killer cell chemotaxis

description: Any process that stops, prevents or reduces the frequency, rate or extent of natural killer cell chemotaxis.


name: CCL5_HUMAN C-C motif chemokine 5 (sprot)

description: A C-C motif chemokine 5 that is encoded in the genome of human.


name: receptor signaling protein tyrosine kinase activator activity

description: Binds to and increases the activity of a receptor signaling protein tyrosine kinase.


CCR4 chemokine receptor binding

description: Binding to a CCR4 chemokine receptor.


chemokine receptor antagonist activity

description: Interacts with chemokine receptors to reduce the action of a chemokine.


name: regulation of chronic inflammatory response

description: Any process that modulates the frequency, rate, or extent of a chronic inflammatory response.


activation of phospholipase D activity

description: Any process that initiates the activity of inactive phospholipase D.


name: negative regulation of macrophage apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process.


SCG2_HUMAN Secretogranin-2 (sprot)

A secretogranin-2 that is encoded in the genome of human.


MYH6_HUMAN Myosin-6 (sprot)

A myosin-6 that is encoded in the genome of human.


visceral muscle development

description: The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure.


regulation of heart growth

description: Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.


MYH8_HUMAN Myosin-8 (sprot)

A myosin-8 that is encoded in the genome of human.


myosin light chain binding

description: Binding to a light chain of a myosin complex.


name: CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (sprot)

description: A cystic fibrosis transmembrane conductance regulator that is encoded in the genome of human.


name: intracellularly ATP-gated chloride channel activity

description: Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane.


Sec61 translocon complex binding

description: Binding to a Sec61 translocon complex.


intracellular pH elevation

description: Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion.


name: positive regulation of cyclic nucleotide-gated ion channel activity

description: Any process that activates or increases the frequency, rate or extent of cyclic nucleotide-gated ion channel activity.


name: positive regulation of voltage-gated chloride channel activity

description: Any process that activates or increases the frequency, rate or extent of voltage-gated chloride channel activity.


CP4B1_HUMAN Cytochrome P450 4B1 (sprot)

A cytochrome P450 4B1 that is encoded in the genome of human.


biphenyl metabolic process

description: The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs).


name: NCAM1_HUMAN Neural cell adhesion molecule 1 (sprot)

description: A neural cell adhesion molecule 1 that is encoded in the genome of human.


name: regulation of semaphorin-plexin signaling pathway

description: Any process that modulates the frequency, rate or extent of semaphorin-plexin signaling pathway.


name: ICAM2_HUMAN Intercellular adhesion molecule 2 (sprot)

description: An intercellular adhesion molecule 2 that is encoded in the genome of human.


name: CSPG2_HUMAN Versican core protein (sprot)

description: A versican core protein that is encoded in the genome of human.


interphotoreceptor matrix

description: A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance.


ITA4_HUMAN Integrin alpha-4 (sprot)

An integrin alpha-4 that is encoded in the genome of human.


name: immune response in gut-associated lymphoid tissue

description: Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules.


name: cell-matrix adhesion involved in ameboidal cell migration

description: The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell.