multi-eIF complex

description: A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.


name: PACR_HUMAN Pituitary adenylate cyclase-activating polypeptide type I receptor (sprot)

description: A pituitary adenylate cyclase-activating polypeptide type I receptor that is encoded in the genome of human.


name: development of primary female sexual characteristics

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion.


name: negative regulation of response to reactive oxygen species

description: Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species.


name: VIPR2_HUMAN Vasoactive intestinal polypeptide receptor 2 (sprot)

description: A vasoactive intestinal polypeptide receptor 2 that is encoded in the genome of human.


name: GRM5_HUMAN Metabotropic glutamate receptor 5 (sprot)

description: A metabotropic glutamate receptor 5 that is encoded in the genome of human.


A2A adenosine receptor binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to an A2A adenosine receptor.


name: phospholipase C-activating G protein-coupled glutamate receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: 5HT2B_HUMAN 5-hydroxytryptamine receptor 2B (sprot)

description: A 5-hydroxytryptamine receptor 2B that is encoded in the genome of human.


name: CCR2_HUMAN C-C chemokine receptor type 2 (sprot)

description: A C-C chemokine receptor type 2 that is encoded in the genome of human.


chemokine (C-C motif) ligand 2 binding

description: Binding to chemokine (C-C motif) ligand 2.


chemokine (C-C motif) ligand 12 binding

description: Binding to chemokine (C-C motif) ligand 12.


name: negative regulation of type 2 immune response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.


T-helper 17 cell chemotaxis

description: The directed movement of a T-helper 17 cell in response to an external stimulus.


name: negative regulation of eosinophil degranulation

description: Any process that stops, prevents, or reduces the rate of eosinophil degranulation.


name: positive regulation of thymocyte migration

description: Any process that activates or increases the frequency, rate or extent of thymocyte migration.


name: positive regulation of monocyte extravasation

description: Any process that activates or increases the frequency, rate or extent of monocyte extravasation.


name: positive regulation of CD8-positive, alpha-beta T cell extravasation

description: Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation.


name: positive regulation of astrocyte chemotaxis

description: Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis.


TSN7_HUMAN Tetraspanin-7 (sprot)

A tetraspanin-7 that is encoded in the genome of human.


name: KPCI_HUMAN Protein kinase C iota type (sprot)

description: A protein kinase C iota type that is encoded in the genome of human.


name: establishment of apical/basal cell polarity

description: The specification and formation of the polarity of a cell along its apical/basal axis.


Golgi vesicle budding

description: The evagination of the Golgi membrane, resulting in formation of a vesicle.


PAR polarity complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC.


name: MC3R_HUMAN Melanocortin receptor 3 (sprot)

description: A melanocortin receptor 3 that is encoded in the genome of human.


name: ELK3_HUMAN ETS domain-containing protein Elk-3 (sprot)

description: An ETS domain-containing protein Elk-3 that is encoded in the genome of human.


name: purine-rich negative regulatory element binding

description: Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes.


ACTY_HUMAN Beta-centractin (sprot)

A beta-centractin that is encoded in the genome of human.


name: CD86_HUMAN T-lymphocyte activation antigen CD86 (sprot)

description: A CD86 molecule that is encoded in the genome of human.


name: ECI1_HUMAN Enoyl-CoA delta isomerase 1, mitochondrial (sprot)

description: An enoyl-CoA Delta isomerase 1, mitochondrial that is encoded in the genome of human.


name: intramolecular oxidoreductase activity, transposing C=C bonds

description: Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears.


name: ASIP_HUMAN Agouti-signaling protein (sprot)

description: An agouti-signaling protein that is encoded in the genome of human.


melanosome transport

description: The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: LAP2A_HUMAN Lamina-associated polypeptide 2, isoform alpha (sprot)


name: LAP2B_HUMAN Lamina-associated polypeptide 2, isoforms beta/gamma (sprot)

description: A lamina-associated polypeptide 2 (human), isoforms beta, gamma, and zeta.


name: STAT1_HUMAN Signal transducer and activator of transcription 1-alpha/beta (sprot)

description: A signal transducer and activator of transcription 1 that is encoded in the genome of human.


name: negative regulation by virus of viral protein levels in host cell

description: Any process where the infecting virus reduces the levels of viral proteins in a cell.


renal tubule development

description: The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.


name: negative regulation of metanephric nephron tubule epithelial cell differentiation

description: Any process that decreases the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation.


ISGF3 complex

description: A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein.


name: STAT6_HUMAN Signal transducer and activator of transcription 6 (sprot)

description: A signal transducer and activator of transcription 6 that is encoded in the genome of human.


regulation of mast cell proliferation

description: Any process that modulates the frequency, rate or extent of mast cell proliferation.


name: cellular response to reactive nitrogen species

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus.


name: STA5A_HUMAN Signal transducer and activator of transcription 5A (sprot)

description: A signal transducer and activator of transcription 5a that is encoded in the genome of human.


reelin-mediated signaling pathway

description: The series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: GRIA1_HUMAN Glutamate receptor 1 (sprot)

description: A glutamate receptor 1 that is encoded in the genome of human.


AMPA glutamate receptor activity

description: An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium.


axonal spine

description: A spine that originates from the axon, usually from the initial segment.


neuron spine

description: A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.


perisynaptic space

description: The extracellular region immediately adjacent to to a synapse.


name: GRIA2_HUMAN Glutamate receptor 2 (sprot)

description: A glutamate receptor 2 that is encoded in the genome of human.


name: ligand-gated monoatomic cation channel activity

description: Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.


postsynaptic endocytic zone

description: A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins.


name: GRIA3_HUMAN Glutamate receptor 3 (sprot)

description: A glutamate receptor 3 that is encoded in the genome of human.


name: MTREX_HUMAN Exosome RNA helicase MTR4 (sprot)

description: An exosome RNA helicase MTR4 that is encoded in the genome of human.


maturation of 5.8S rRNA

description: Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule.


snRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein.


TRAMP complex

description: A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control.


name: AK1C3_HUMAN Aldo-keto reductase family 1 member C3 (sprot)

description: An aldo-keto reductase family 1 member C3 that is encoded in the genome of human.


description: Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide.


name: prostaglandin D2 11-ketoreductase activity

description: Catalysis of the reaction: prostaglandin D2 + H+ + NADPH = 11-epi-prostaglandin F2alpha + NADP+.


ketoreductase activity

description: Catalysis of the reduction of a ketone group to form the corresponding alcohol.


prostaglandin F synthase activity

description: Catalysis of the reaction: NADP+ + prostaglandin F2alpha = H+ + NADPH + prostaglandin D2.


ketosteroid monooxygenase activity

description: Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate.


description: Catalysis of the reaction: a 3-oxo-5beta-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + H+ + NADPH. The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3- one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates.


macromolecule metabolic process

description: The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.


name: regulation of retinoic acid receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity.


name: cellular response to prostaglandin stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus.


name: cellular response to corticosteroid stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids.


name: RHG25_HUMAN Rho GTPase-activating protein 25 (sprot)

description: A Rho GTPase-activating protein 25 that is encoded in the genome of human.


name: PK3CA_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (sprot)

description: A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform that is encoded in the genome of human.


response to muscle inactivity

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus.


name: negative regulation of actin filament depolymerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.


name: cellular response to hydrostatic pressure

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it.


autosome genomic imprinting

description: The establishment of epigenetic modifications (imprints) in autosomal (non-sexual) chromosomes during gametogenesis, and propagation of these imprints during the organism's life. Genomic imprinting leads to an asymmetry between the maternal and paternal alleles and differential expression of the corresponding alleles. This can happen through heterochromatin formation or differential chromatin loop formation.


response to butyrate

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus.


name: negative regulation of fibroblast apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.


name: PK3CB_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (sprot)

description: A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform that is encoded in the genome of human.


name: MTOR_HUMAN Serine/threonine-protein kinase mTOR (sprot)

description: A serine/threonine-protein kinase mTOR that is encoded in the genome of human.


name: RNA polymerase III type 1 promoter sequence-specific DNA binding

description: Binding to a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition.


name: RNA polymerase III type 2 promoter sequence-specific DNA binding

description: Binding to a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs.


name: RNA polymerase III type 3 promoter sequence-specific DNA binding

description: Binding to a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.


name: TFIIIC-class transcription factor complex binding

description: Binding to a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.


cellular response to L-leucine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-leucine stimulus.


name: negative regulation of lysosome organization

description: Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization.


name: positive regulation of pentose-phosphate shunt

description: Any process that activates or increases the frequency, rate or extent of pentose-phosphate shunt.


name: PI4KA_HUMAN Phosphatidylinositol 4-kinase alpha (sprot)

description: A phosphatidylinositol 4-kinase alpha that is encoded in the genome of human.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H+.


name: reorganization of cellular membranes to establish viral sites of replication

description: A process in intracellular membranes are reorganized by viral proteins that perturb membrane integrity and can cause an extensive rearrangement of cellular membranes, forming membranous webs, which are thought to be the site of replication or certain viruses, for example the HPV virus.


name: HUTH_HUMAN Histidine ammonia-lyase (sprot)

description: A histidine ammonia-lyase that is encoded in the genome of human.


histidine ammonia-lyase activity

description: Catalysis of the reaction: L-histidine = urocanate + NH3.


name: EPS15_HUMAN Epidermal growth factor receptor substrate 15 (sprot)

description: An epidermal growth factor receptor substrate 15 that is encoded in the genome of human.


AF9_HUMAN Protein AF-9 (sprot)

A protein AF-9 that is encoded in the genome of human.


CASP3_HUMAN Caspase-3 (sprot)

A caspase-3 that is encoded in the genome of human.


phospholipase A2 activator activity

description: Binds to and increases the activity of the enzyme phospholipase A2.


name: cysteine-type endopeptidase activity involved in apoptotic process

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process.


name: cysteine-type endopeptidase activity involved in apoptotic signaling pathway

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway.


name: cysteine-type endopeptidase activity involved in execution phase of apoptosis

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis.


luteolysis

description: The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy.


name: intrinsic apoptotic signaling pathway in response to osmotic stress

description: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered.


leukocyte apoptotic process

description: Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.


CASP2_HUMAN Caspase-2 (sprot)

A caspase-2 that is encoded in the genome of human.


endopeptidase complex

description: A protein complex which is capable of endopeptidase activity.


name: DPP6_HUMAN Dipeptidyl aminopeptidase-like protein 6 (sprot)

description: A dipeptidyl aminopeptidase-like protein 6 that is encoded in the genome of human.


name: RS27_HUMAN Small ribosomal subunit protein eS27 (sprot)

description: A small ribosomal subunit protein eS27 that is encoded in the genome of human.


name: MATK_HUMAN Megakaryocyte-associated tyrosine-protein kinase (sprot)

description: A megakaryocyte-associated tyrosine-protein kinase that is encoded in the genome of human.


name: TEC_HUMAN Tyrosine-protein kinase Tec (sprot)

description: A tyrosine-protein kinase Tec that is encoded in the genome of human.


name: TXK_HUMAN Tyrosine-protein kinase TXK (sprot)

description: A tyrosine-protein kinase TXK that is encoded in the genome of human.


name: ABL2_HUMAN Tyrosine-protein kinase ABL2 (sprot)

description: A tyrosine-protein kinase ABL2 that is encoded in the genome of human.


name: FRK_HUMAN Tyrosine-protein kinase FRK (sprot)

description: A tyrosine-protein kinase FRK that is encoded in the genome of human.


name: HELZ_HUMAN Probable helicase with zinc finger domain (sprot)

description: A probable helicase with zinc finger domain that is encoded in the genome of human.


name: CNDD3_HUMAN Condensin-2 complex subunit D3 (sprot)

description: A condensin-2 complex subunit D3 that is encoded in the genome of human.


name: RBM34_HUMAN RNA-binding protein 34 (sprot)

description: An RNA-binding protein 34 that is encoded in the genome of human.


name: I12R1_HUMAN Interleukin-12 receptor subunit beta-1 (sprot)

description: An interleukin-12 receptor subunit beta-1 that is encoded in the genome of human.


interleukin-12 receptor activity

description: Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


interleukin-23 binding

description: Binding to interleukin-23.


interleukin-23 receptor activity

description: Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: LIFR_HUMAN Leukemia inhibitory factor receptor (sprot)

description: A leukemia inhibitory factor receptor that is encoded in the genome of human.


name: LPPRC_HUMAN Leucine-rich PPR motif-containing protein, mitochondrial (sprot)

description: A leucine-rich PPR motif-containing protein, mitochondrial that is encoded in the genome of human.


mitochondrial RNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.


name: negative regulation of mitochondrial RNA catabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.


name: THIM_HUMAN 3-ketoacyl-CoA thiolase, mitochondrial (sprot)

description: A 3-ketoacyl-CoA thiolase, mitochondrial that is encoded in the genome of human.


name: RL35_HUMAN Large ribosomal subunit protein uL29 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL29 that is encoded in the genome of human.


name: WASP_HUMAN Actin nucleation-promoting factor WAS (sprot)

description: An actin nucleation-promoting factor WAS that is encoded in the genome of human.


name: regulation of T cell antigen processing and presentation

description: Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation.


name: CDN2A_HUMAN Cyclin-dependent kinase inhibitor 2A (sprot)

description: A cyclin-dependent kinase inhibitor 2A (human), isoforms h1, h2, h3, and h5.


name: positive regulation of macrophage apoptotic process

description: Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process.


name: CDN2B_HUMAN Cyclin-dependent kinase 4 inhibitor B (sprot)

description: A cyclin-dependent kinase 4 inhibitor B that is encoded in the genome of human.


name: CDN2C_HUMAN Cyclin-dependent kinase 4 inhibitor C (sprot)

description: A cyclin-dependent kinase 4 inhibitor C that is encoded in the genome of human.


name: PCP_HUMAN Lysosomal Pro-X carboxypeptidase (sprot)

description: A lysosomal Pro-X carboxypeptidase that is encoded in the genome of human.


name: CXCL5_HUMAN C-X-C motif chemokine 5 (sprot)

description: A C-X-C motif chemokine 5 that is encoded in the genome of human.


name: NSG1_HUMAN Neuronal vesicle trafficking-associated protein 1 (sprot)

description: A neuronal vesicle trafficking-associated protein 1 that is encoded in the genome of human.


receptor recycling

description: The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.


spontaneous synaptic transmission

description: The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential.


name: neurotransmitter receptor transport, endosome to postsynaptic membrane

description: The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.


neurotransmitter receptor cycle

description: The process during which neurotransmitter receptors, anchored in some region of the synaptic membrane, are recycled via the endosome. This cycle includes release from anchoring, diffusion in the synaptic membrane to an endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent anchoring (trapping).


name: postsynaptic neurotransmitter receptor cycle

description: The process during which neurotransmitter receptors in the postsynaptic specialization membrane are recycled via the endosome. This cycle includes release from anchoring (trapping), diffusion in the synaptic membrane to the postsynaptic endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent trapping in the postsynaptic specialization membrane.


HD_HUMAN Huntingtin (sprot)

A huntingtin that is encoded in the genome of human.


name: positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

description: Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.


vocal learning

description: A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others.


name: regulation of CAMKK-AMPK signaling cascade

description: Any process that modulates the frequency, rate or extent of CAMKK-AMPK signaling cascade.


name: ECE1_HUMAN Endothelin-converting enzyme 1 (sprot)

description: An endothelin-converting enzyme 1 that is encoded in the genome of human.


calcitonin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin.


endothelin maturation

description: The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin.


name: MTHR_HUMAN Methylenetetrahydrofolate reductase (NADPH) (sprot)

description: A methylenetetrahydrofolate reductase (NADPH) that is encoded in the genome of human.


name: methylenetetrahydrofolate reductase (NAD(P)H) activity

description: Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.


name: methylenetetrahydrofolate reductase (NADPH) activity

description: Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP+ = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H+.


response to vitamin B2

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus.


S-adenosylmethionine metabolic process

description: The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.


name: EAA1_HUMAN Excitatory amino acid transporter 1 (sprot)

description: An excitatory amino acid transporter 1 that is encoded in the genome of human.


name: L-aspartate import across plasma membrane

description: The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol.


membrane protein complex

description: Any protein complex that is part of a membrane.


name: EAA2_HUMAN Excitatory amino acid transporter 2 (sprot)

description: An excitatory amino acid transporter 2 that is encoded in the genome of human.


name: cysteine transmembrane transporter activity

description: Enables the transfer of cysteine from one side of a membrane to the other.


neurotransmitter reuptake

description: The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol.


cysteine transmembrane transport

description: The directed movement of cysteine across a membrane.


name: EAA3_HUMAN Excitatory amino acid transporter 3 (sprot)

description: An excitatory amino acid transporter 3 that is encoded in the genome of human.


monoatomic anion channel activity

description: Enables the energy-independent facilitated diffusion of a monoatomic anion through a transmembrane aqueous pore or channel.


name: L-aspartate transmembrane transporter activity

description: Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid.


name: D-aspartate transmembrane transporter activity

description: Enables the transfer of D-aspartate from one side of a membrane to the other.


cysteine transport

description: The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


D-aspartate transmembrane transport

description: The process in which D-aspartate, the D-enantiomer of the anion of (2R)-2-aminobutanedioic acid  is transported across a lipid bilayer, from one side of a membrane to the other, by means of some agent such as a transporter or pore.


response to anesthetic

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation.


name: regulation of protein targeting to membrane

description: Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.


name: neurotransmitter receptor transport to plasma membrane

description: The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles.


name: SATT_HUMAN Neutral amino acid transporter A (sprot)

description: A neutral amino acid transporter A that is encoded in the genome of human.


name: L-glutamine transmembrane transporter activity

description: Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid.


name: L-proline transmembrane transporter activity

description: Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid.


name: L-serine transmembrane transporter activity

description: Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid.


name: L-threonine transmembrane transporter activity

description: Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid.


name: L-hydroxyproline transmembrane transporter activity

description: Enables the transfer of L-hydroxyproline from one side of a membrane to the other.


glutamine transport

description: The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


L-alanine transport

description: The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


L-serine transport

description: The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


threonine transport

description: The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


hydroxyproline transport

description: The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


proline transmembrane transport

description: The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore.


L-serine import across plasma membrane

description: The directed movement of L-serine into a cell.


name: GDF5_HUMAN Growth/differentiation factor 5 (sprot)

description: A growth/differentiation factor 5 that is encoded in the genome of human.


name: LIS1_HUMAN Platelet-activating factor acetylhydrolase IB subunit beta (sprot)

description: A platelet-activating factor acetylhydrolase IB subunit beta that is encoded in the genome of human.


ameboidal-type cell migration

description: Cell migration that is accomplished by extension and retraction of a pseudopodium.


corpus callosum morphogenesis

description: The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres.


name: establishment of planar polarity of embryonic epithelium

description: Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates.


nuclear membrane disassembly

description: The controlled breakdown of the nuclear membranes, for example during cellular division.


maintenance of centrosome location

description: Any process in which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere.


name: microtubule cytoskeleton organization involved in establishment of planar polarity

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity.


astral microtubule

description: Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.


central region of growth cone

description: The center of the migrating motile tip of a growing nerve cell axon or dendrite.


kinesin complex

description: Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.


description: An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF).


name: GUC1A_HUMAN Guanylyl cyclase-activating protein 1 (sprot)

description: A guanylyl cyclase-activating protein 1 that is encoded in the genome of human.


guanylate cyclase regulator activity

description: Modulates the activity of guanylate cyclase.


name: PF2R_HUMAN Prostaglandin F2-alpha receptor (sprot)

description: A prostaglandin F2-alpha receptor that is encoded in the genome of human.


prostaglandin F receptor activity

description: Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity.


name: PE2R3_HUMAN Prostaglandin E2 receptor EP3 subtype (sprot)

description: A prostaglandin E2 receptor EP3 subtype that is encoded in the genome of human.


name: PE2R2_HUMAN Prostaglandin E2 receptor EP2 subtype (sprot)

description: A prostaglandin E2 receptor EP2 subtype that is encoded in the genome of human.


name: PI2R_HUMAN Prostacyclin receptor (sprot)

description: A prostacyclin receptor that is encoded in the genome of human.


name: MUC18_HUMAN Cell surface glycoprotein MUC18 (sprot)

description: A cell surface glycoprotein MUC18 that is encoded in the genome of human.


DCC_HUMAN Netrin receptor DCC (sprot)

A netrin receptor DCC that is encoded in the genome of human.


name: negative regulation of dendrite development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development.


name: CACP_HUMAN Carnitine O-acetyltransferase (sprot)

description: A carnitine O-acetyltransferase that is encoded in the genome of human.


acyl-CoA oxidase activity

description: Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide.


carnitine O-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA.


name: short-chain fatty acid metabolic process

description: The chemical reactions and pathways involving a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.


CAH7_HUMAN Carbonic anhydrase 7 (sprot)

A carbonic anhydrase 7 that is encoded in the genome of human.


name: GLP1R_HUMAN Glucagon-like peptide 1 receptor (sprot)

description: A glucagon-like peptide 1 receptor that is encoded in the genome of human.


name: glucagon-like peptide 1 receptor activity

description: Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein.


CATO_HUMAN Cathepsin O (sprot)

A cathepsin O that is encoded in the genome of human.


CATK_HUMAN Cathepsin K (sprot)

A cathepsin K that is encoded in the genome of human.


MATR3_HUMAN Matrin-3 (sprot)

A matrin-3 that is encoded in the genome of human.


name: MSH2_HUMAN DNA mismatch repair protein Msh2 (sprot)

description: A DNA mismatch repair protein Msh2 that is encoded in the genome of human.


single thymine insertion binding

description: Binding to a double-stranded DNA region containing a single thymine insertion or a deletion that results in an unpaired thymine.


name: somatic recombination of immunoglobulin gene segments

description: The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.


MutSalpha complex

description: A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6.


name: GRK6_HUMAN G protein-coupled receptor kinase 6 (sprot)

description: A G protein-coupled receptor kinase 6 that is encoded in the genome of human.


BTD_HUMAN Biotinidase (sprot)

A biotinidase that is encoded in the genome of human.


biotinidase activity

description: Catalysis of the reaction: biotin amide + H2O = biotin + NH3.


biotin metabolic process

description: The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.


name: ETV4_HUMAN ETS translocation variant 4 (sprot)

description: An ETS translocation variant 4 that is encoded in the genome of human.


name: GPDM_HUMAN Glycerol-3-phosphate dehydrogenase, mitochondrial (sprot)

description: A glycerol-3-phosphate dehydrogenase, mitochondrial that is encoded in the genome of human.


glycerol-3-phosphate metabolic process

description: The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol.


name: SSRA_HUMAN Translocon-associated protein subunit alpha (sprot)

description: A translocon-associated protein subunit alpha that is encoded in the genome of human.


name: SSRB_HUMAN Translocon-associated protein subunit beta (sprot)

description: A translocon-associated protein subunit beta that is encoded in the genome of human.


CRBB2_HUMAN Beta-crystallin B2 (sprot)

A beta-crystallin B2 that is encoded in the genome of human.


name: RAD52_HUMAN DNA repair protein RAD52 homolog (sprot)

description: A DNA repair protein RAD52 homolog that is encoded in the genome of human.


name: DNA double-strand break processing involved in repair via single-strand annealing

description: The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing.


DNA recombinase assembly

description: The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA.


name: AL3B1_HUMAN Aldehyde dehydrogenase family 3 member B1 (sprot)

description: An aldehyde dehydrogenase family 3 member B1 that is encoded in the genome of human.


name: benzaldehyde dehydrogenase (NADP+) activity

description: Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+.


name: NR4A2_HUMAN Nuclear receptor subfamily 4 group A member 2 (sprot)

description: A nuclear receptor subfamily 4 group A member 2 that is encoded in the genome of human.


general adaptation syndrome

description: General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses.


name: MAGA1_HUMAN Melanoma-associated antigen 1 (sprot)

description: A melanoma-associated antigen 1 that is encoded in the genome of human.


name: MAGA2_HUMAN Melanoma-associated antigen 2 (sprot)

description: A melanoma-associated antigen 2 that is encoded in the genome of human.


name: negative regulation of protein acetylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation.


name: MAGA3_HUMAN Melanoma-associated antigen 3 (sprot)

description: A melanoma-associated antigen 3 that is encoded in the genome of human.


name: MAGA4_HUMAN Melanoma-associated antigen 4 (sprot)

description: A melanoma-associated antigen 4 that is encoded in the genome of human.


name: MAGA5_HUMAN Putative melanoma-associated antigen 5P (sprot)

description: A putative melanoma-associated antigen 5P that is encoded in the genome of human.


name: MAGA6_HUMAN Melanoma-associated antigen 6 (sprot)

description: A melanoma-associated antigen 6 that is encoded in the genome of human.


name: MAGA8_HUMAN Melanoma-associated antigen 8 (sprot)

description: A melanoma-associated antigen 8 that is encoded in the genome of human.


name: MAGA9_HUMAN Melanoma-associated antigen 9 (sprot)

description: A melanoma-associated antigen 9 that is encoded in the genome of human.


name: MAGAA_HUMAN Melanoma-associated antigen 10 (sprot)

description: A melanoma-associated antigen 10 that is encoded in the genome of human.


name: MAGAB_HUMAN Melanoma-associated antigen 11 (sprot)

description: A melanoma-associated antigen 11 that is encoded in the genome of human.


name: MAGAC_HUMAN Melanoma-associated antigen 12 (sprot)

description: A melanoma-associated antigen 12 that is encoded in the genome of human.


name: PTN9_HUMAN Tyrosine-protein phosphatase non-receptor type 9 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 9 that is encoded in the genome of human.


name: ZAP70_HUMAN Tyrosine-protein kinase ZAP-70 (sprot)

description: A tyrosine-protein kinase ZAP-70 that is encoded in the genome of human.


beta selection

description: The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell.


name: KSYK_HUMAN Tyrosine-protein kinase SYK (sprot)

description: A tyrosine-protein kinase SYK that is encoded in the genome of human.


interleukin-15 receptor binding

description: Binding to an interleukin-15 receptor.


serotonin secretion by platelet

description: The regulated release of serotonin by a platelet or group of platelets.


name: positive regulation of interleukin-3 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-3 production.


name: regulation of superoxide anion generation

description: Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell.


regulation of neutrophil degranulation

description: Any process that modulates the frequency, rate, or extent of neutrophil degranulation.


name: cellular response to molecule of fungal origin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.


name: regulation of arachidonic acid secretion

description: Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue.


name: RANG_HUMAN Ran-specific GTPase-activating protein (sprot)

description: A Ran-specific GTPase-activating protein that is encoded in the genome of human.


name: TNR4_HUMAN Tumor necrosis factor receptor superfamily member 4 (sprot)

description: A tumor necrosis factor receptor superfamily member 4 that is encoded in the genome of human.


name: NAMPT_HUMAN Nicotinamide phosphoribosyltransferase (sprot)

description: A nicotinamide phosphoribosyltransferase that is encoded in the genome of human.


description: Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide.


name: KI2L1_HUMAN Killer cell immunoglobulin-like receptor 2DL1 (sprot)

description: A killer cell immunoglobulin-like receptor 2DL1 that is encoded in the genome of human.


name: KI2L2_HUMAN Killer cell immunoglobulin-like receptor 2DL2 (sprot)

description: A killer cell immunoglobulin-like receptor 2DL2 that is encoded in the genome of human.


name: KI2L3_HUMAN Killer cell immunoglobulin-like receptor 2DL3 (sprot)

description: A killer cell immunoglobulin-like receptor 2DL3 that is encoded in the genome of human.


name: KI3L1_HUMAN Killer cell immunoglobulin-like receptor 3DL1 (sprot)

description: A killer cell immunoglobulin-like receptor 3DL1 that is encoded in the genome of human.


name: HLA-B specific inhibitory MHC class I receptor activity

description: Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte.


name: KI3L2_HUMAN Killer cell immunoglobulin-like receptor 3DL2 (sprot)

description: A killer cell immunoglobulin-like receptor 3DL2 that is encoded in the genome of human.


MHC class Ib protein binding

description: Binding to a major histocompatibility complex class Ib molecules.


name: KI2S2_HUMAN Killer cell immunoglobulin-like receptor 2DS2 (sprot)

description: A killer cell immunoglobulin-like receptor 2DS2 that is encoded in the genome of human.


name: KI2S4_HUMAN Killer cell immunoglobulin-like receptor 2DS4 (sprot)

description: A killer cell immunoglobulin-like receptor 2DS4 that is encoded in the genome of human.


AFAM_HUMAN Afamin (sprot)

An afamin that is encoded in the genome of human.


name: protein transport within extracellular region

description: The directed movement of proteins in the extracellular region, by means of some agent such as a transporter or pore.


name: LPAR6_HUMAN Lysophosphatidic acid receptor 6 (sprot)

description: An oleoyl-L-alpha-lysophosphatidic acid receptor that is encoded in the genome of human.


name: ACHA4_HUMAN Neuronal acetylcholine receptor subunit alpha-4 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-4 that is encoded in the genome of human.


name: PRS6B_HUMAN 26S proteasome regulatory subunit 6B (sprot)

description: A 26S proteasome regulatory subunit 6B that is encoded in the genome of human.


name: GATA4_HUMAN Transcription factor GATA-4 (sprot)

description: A transcription factor GATA-4 that is encoded in the genome of human.


atrioventricular node development

description: The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system.


atrioventricular valve formation

description: The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.


cardiac muscle tissue regeneration

description: The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.


name: NKX21_HUMAN Homeobox protein Nkx-2.1 (sprot)

description: A homeobox protein Nkx-2.1 that is encoded in the genome of human.


globus pallidus development

description: The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain.


forebrain neuron fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain.


name: cerebral cortex GABAergic interneuron differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex.


developmental induction

description: A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder).


name: EFTS_HUMAN Elongation factor Ts, mitochondrial (sprot)

description: An elongation factor Ts, mitochondrial that is encoded in the genome of human.


name: regulation of DNA-templated transcription elongation

description: Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.


name: TNNT3_HUMAN Troponin T, fast skeletal muscle (sprot)

description: A troponin T, fast skeletal muscle that is encoded in the genome of human.


troponin I binding

description: Binding to troponin I, the inhibitory subunit of the troponin complex.


name: positive regulation of calcium-dependent ATPase activity

description: Any process that activates or increases the frequency, rate or extent of calcium-dependent ATPase activity.


name: TNNT2_HUMAN Troponin T, cardiac muscle (sprot)

description: A troponin T, cardiac muscle that is encoded in the genome of human.


ACY2_HUMAN Aspartoacylase (sprot)

An aspartoacylase that is encoded in the genome of human.


aspartoacylase activity

description: Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate.


acetate metabolic process

description: The chemical reactions and pathways involving acetate, the anion of acetic acid.


MMP13_HUMAN Collagenase 3 (sprot)

A collagenase 3 that is encoded in the genome of human.


name: ABCG1_HUMAN ATP-binding cassette sub-family G member 1 (sprot)

description: An ATP-binding cassette sub-family G member 1 that is encoded in the genome of human.


ABC-type sterol transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out).


lipid translocation

description: The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.


glycoprotein transport

description: The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: cellular response to high density lipoprotein particle stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus.


name: PPIC_HUMAN Peptidyl-prolyl cis-trans isomerase C (sprot)

description: A eukaryotic-type peptidyl-prolyl cis-trans isomerase C that is encoded in the genome of human.


name: VDAC2_HUMAN Voltage-dependent anion-selective channel protein 2 (sprot)

description: A voltage-dependent anion-selective channel protein 2 that is encoded in the genome of human.


name: negative regulation of protein polymerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers.


name: ACDSB_HUMAN Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (sprot)

description: A short/branched chain specific acyl-CoA dehydrogenase, mitochondrial that is encoded in the genome of human.


description: Catalysis of the reaction: 2-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein].


name: short-chain fatty acyl-CoA dehydrogenase activity

description: Catalysis of the reaction: a short-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.


description: Catalysis of the reaction: 2-methylpropanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein].


name: CBX5_HUMAN Chromobox protein homolog 5 (sprot)

description: A chromobox protein homolog 5 that is encoded in the genome of human.


name: UBP5_HUMAN Ubiquitin carboxyl-terminal hydrolase 5 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 5 that is encoded in the genome of human.


name: MK08_HUMAN Mitogen-activated protein kinase 8 (sprot)

description: A mitogen-activated protein kinase 8 that is encoded in the genome of human.


JUN phosphorylation

description: The process of introducing a phosphate group into a JUN protein.


JUN kinase activity

description: Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors.


positive regulation of cell killing

description: Any process that activates or increases the frequency, rate or extent of cell killing.


name: MK09_HUMAN Mitogen-activated protein kinase 9 (sprot)

description: A mitogen-activated protein kinase 9 that is encoded in the genome of human.


name: protein localization to tricellular tight junction

description: A process in which a protein is transported to, or maintained in, a location within a tricellular tight junction.


name: MP2K4_HUMAN Dual specificity mitogen-activated protein kinase kinase 4 (sprot)

description: A dual specificity mitogen-activated protein kinase kinase 4 that is encoded in the genome of human.


smooth muscle cell apoptotic process

description: Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels.


name: KI67_HUMAN Proliferation marker protein Ki-67 (sprot)

description: A proliferation marker protein Ki-67 that is encoded in the genome of human.


name: KPB2_HUMAN Phosphorylase b kinase regulatory subunit alpha, liver isoform (sprot)

description: A phosphorylase b kinase regulatory subunit alpha, liver isoform that is encoded in the genome of human.


name: KPB1_HUMAN Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (sprot)

description: A phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform that is encoded in the genome of human.


name: S15A1_HUMAN Solute carrier family 15 member 1 (sprot)

description: A solute carrier family 15 member 1 that is encoded in the genome of human.


name: proton-dependent oligopeptide secondary active transmembrane transporter activity

description: Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement.


name: peptide:proton symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement.


name: tripeptide transmembrane transporter activity

description: Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other.


name: dipeptide transmembrane transporter activity

description: Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.


dipeptide import across plasma membrane

description: The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol.


name: tripeptide import across plasma membrane

description: The directed movement of a tripeptide from outside of a cell, across the plasma membrane and into the cytosol.


name: RAGP1_HUMAN Ran GTPase-activating protein 1 (sprot)

description: A Ran GTPase-activating protein 1 that is encoded in the genome of human.


SUMO ligase complex

description: A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase and other proteins that may confer substrate specificity of the complex.


name: cytoplasmic periphery of the nuclear pore complex

description: Cytoplasm situated in close proximity to a nuclear pore complex.


nuclear pore cytoplasmic filaments

description: Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component.


name: RECQ1_HUMAN ATP-dependent DNA helicase Q1 (sprot)

description: An ATP-dependent DNA helicase Q1 that is encoded in the genome of human.


name: NOP2_HUMAN Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (sprot)

description: A probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase that is encoded in the genome of human.


description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA.


ribosomal large subunit assembly

description: The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.


name: GPR3_HUMAN G-protein coupled receptor 3 (sprot)

description: A G-protein coupled receptor 3 that is encoded in the genome of human.


name: CML2_HUMAN Chemerin-like receptor 2 (sprot)

description: A chemerin-like receptor 2 that is encoded in the genome of human.


adipokinetic hormone receptor activity

description: Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.


adipokinetic hormone binding

description: Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.


name: CCR10_HUMAN C-C chemokine receptor type 10 (sprot)

description: A C-C chemokine receptor type 10 that is encoded in the genome of human.


name: GPR4_HUMAN G-protein coupled receptor 4 (sprot)

description: A G-protein coupled receptor 4 that is encoded in the genome of human.


glomerular mesangial cell development

description: The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure.


name: XCR1_HUMAN Chemokine XC receptor 1 (sprot)

description: A chemokine XC receptor 1 that is encoded in the genome of human.


name: GPR6_HUMAN G-protein coupled receptor 6 (sprot)

description: A G-protein coupled receptor 6 that is encoded in the genome of human.


name: 5HT3A_HUMAN 5-hydroxytryptamine receptor 3A (sprot)

description: A 5-hydroxytryptamine receptor 3A that is encoded in the genome of human.


name: ATRX_HUMAN Transcriptional regulator ATRX (sprot)

description: A transcriptional regulator ATRX that is encoded in the genome of human.


DNA translocase activity

description: Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis.


post-embryonic forelimb morphogenesis

description: The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an organism.


cellular response to hydroxyurea

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.


chromosome, subtelomeric region

description: A region of the chromosome, adjacent to the telomere (on the centromeric side) that contains repetitive DNA and sometimes genes. This region is usually heterochromatin.


CRK_HUMAN Adapter molecule crk (sprot)

An adapter molecule crk that is encoded in the genome of human.


name: protein phosphorylated amino acid binding

description: Binding to a phosphorylated amino acid residue within a protein.


helper T cell diapedesis

description: The passage of a helper T cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation.


response to hepatocyte growth factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.


postsynaptic specialization assembly

description: The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane.


cerebellar neuron development

description: The process whose specific outcome is the progression of a cerebellar neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.


name: regulation of intracellular signal transduction

description: Any process that modulates the frequency, rate or extent of intracellular signal transduction.


cellular response to endothelin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3).


CRKL_HUMAN Crk-like protein (sprot)

A Crk-like protein that is encoded in the genome of human.


name: positive regulation of glial cell migration

description: Any process that activates or increases the frequency, rate or extent of glial cell migration.


name: extrinsic component of postsynaptic membrane

description: The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


name: IF2M_HUMAN Translation initiation factor IF-2, mitochondrial (sprot)

description: A translation initiation factor IF-2, mitochondrial that is encoded in the genome of human.


mitochondrial translational initiation

description: The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.


name: BAG6_HUMAN Large proline-rich protein BAG6 (sprot)

description: A large proline-rich protein BAT3 that is encoded in the genome of human.


maintenance of unfolded protein

description: Maintaining a protein in an unfolded, soluble state.


name: endoplasmic reticulum stress-induced pre-emptive quality control

description: The response to endoplasimic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome.


name: GSTM5_HUMAN Glutathione S-transferase Mu 5 (sprot)

description: A glutathione S-transferase mu 5 that is encoded in the genome of human.


NSF_HUMAN Vesicle-fusing ATPase (sprot)

A vesicle-fusing ATPase that is encoded in the genome of human.


SNARE complex disassembly

description: The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


name: CDN1B_HUMAN Cyclin-dependent kinase inhibitor 1B (sprot)

description: A cyclin-dependent kinase inhibitor 1B that is encoded in the genome of human.


name: cyclin-dependent protein kinase activating kinase regulator activity

description: Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase.


autophagic cell death

description: A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.


name: regulation of lens fiber cell differentiation

description: Any process that modulates the frequency, rate or extent of lens fiber cell differentiation.


Cul4A-RING E3 ubiquitin ligase complex

description: A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.


name: NOTC1_HUMAN Neurogenic locus notch homolog protein 1 (sprot)

description: A neurogenic locus notch homolog protein 1 that is encoded in the genome of human.


endocardium morphogenesis

description: The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.


coronary sinus valve morphogenesis

description: The process in which the structure of the coronary sinus valve is generated and organized.


mitral valve formation

description: The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.


growth involved in heart morphogenesis

description: Developmental growth that contributes to the shaping of the heart.


name: negative regulation of cell proliferation involved in heart valve morphogenesis

description: Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.


name: Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation

description: The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.


name: positive regulation of transcription of Notch receptor target

description: The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain.


foregut morphogenesis

description: The process in which the anatomical structures of the foregut are generated and organized.


auditory receptor cell fate commitment

description: The process in which the cellular identity of auditory hair cells is acquired and determined.


cell differentiation in spinal cord

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.


name: secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

description: The process in which a relatively unspecialized epithelial cell acquires specialized features of a secretory columnal luminar epithelial cell of the prostate.


name: regulation of epithelial cell proliferation involved in prostate gland development

description: Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.


name: arterial endothelial cell differentiation

description: The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries.


venous endothelial cell differentiation

description: The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins.


name: vasculogenesis involved in coronary vascular morphogenesis

description: The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes.


name: regulation of cell adhesion involved in heart morphogenesis

description: Any process that modulates the extent of cell adhesion contributing to the shaping of the heart.


name: positive regulation of cardiac epithelial to mesenchymal transition

description: Any process that starts or increases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


cellular response to tumor cell

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell.


distal tubule development

description: The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule.


name: positive regulation of aorta morphogenesis

description: Any process that activates or increases the frequency, rate or extent of aorta morphogenesis.


name: negative regulation of pro-B cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation.


MAML1-RBP-Jkappa- ICN1 complex

description: A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.


name: ASMT_HUMAN Acetylserotonin O-methyltransferase (sprot)

description: An acetylserotonin O-methyltransferase that is encoded in the genome of human.


S-methyltransferase activity

description: Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule.


description: Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine.


melatonin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine).


indolalkylamine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group.


name: BKRB1_HUMAN B1 bradykinin receptor (sprot)

description: A B1 bradykinin receptor that is encoded in the genome of human.


name: IEX1_HUMAN Radiation-inducible immediate-early gene IEX-1 (sprot)

description: A radiation-inducible immediate-early gene IEX-1 that is encoded in the genome of human.


name: SO1A2_HUMAN Solute carrier organic anion transporter family member 1A2 (sprot)

description: A solute carrier organic anion transporter family member 1A2 that is encoded in the genome of human.


name: MP2K3_HUMAN Dual specificity mitogen-activated protein kinase kinase 3 (sprot)

description: A dual specificity mitogen-activated protein kinase kinase 3 that is encoded in the genome of human.


name: BRCC3_HUMAN Lys-63-specific deubiquitinase BRCC36 (sprot)

description: A lys-63-specific deubiquitinase BRCC36 that is encoded in the genome of human.


name: RL27A_HUMAN Large ribosomal subunit protein uL15 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL15 that is encoded in the genome of human.


name: RL5_HUMAN Large ribosomal subunit protein uL18 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL18 that is encoded in the genome of human.


5S rRNA binding

description: Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome.


name: negative regulation of protein neddylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation.


name: RL21_HUMAN Large ribosomal subunit protein eL21 (sprot)

description: A large ribosomal subunit protein eL21 that is encoded in the genome of human.


name: RL28_HUMAN Large ribosomal subunit protein eL28 (sprot)

description: A large ribosomal subunit protein eL28 that is encoded in the genome of human.


name: RS9_HUMAN Small ribosomal subunit protein uS4 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS4 that is encoded in the genome of human.


name: RS5_HUMAN Small ribosomal subunit protein uS7 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS7 that is encoded in the genome of human.


name: RS10_HUMAN Small ribosomal subunit protein eS10 (sprot)

description: A small ribosomal subunit protein eS10 that is encoded in the genome of human.


name: MAP1B_HUMAN Microtubule-associated protein 1B (sprot)

description: A microtubule-associated protein 1B that is encoded in the genome of human.


developmental maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state.


name: induction of synaptic plasticity by chemical substance

description: The process in which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require.


name: establishment of monopolar cell polarity

description: The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis.


hippocampal mossy fiber

description: An axon of a hippocampal granule cell, including dentate gyrus granule cell and CA3 granule cell, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal.


name: GNPI1_HUMAN Glucosamine-6-phosphate isomerase 1 (sprot)

description: A glucosamine-6-phosphate isomerase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4.


glucosamine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin.


name: NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4 (sprot)

description: An E3 ubiquitin-protein ligase NEDD4 that is encoded in the genome of human.


viral budding

description: A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space.


sodium channel inhibitor activity

description: Binds to and stops, prevents, or reduces the activity of a sodium channel.


phosphothreonine residue binding

description: Binding to a phosphorylated threonine residue within a protein.


name: formation of structure involved in a symbiotic process

description: The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction.


name: positive regulation of nucleocytoplasmic transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.


name: negative regulation of sodium ion transmembrane transporter activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity.


name: YAP1_HUMAN Transcriptional coactivator YAP1 (sprot)

description: A transcriptional coactivator YAP1 that is encoded in the genome of human.


embryonic heart tube morphogenesis

description: The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.


name: polarized epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis.


enterocyte differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of an enterocyte.


UTRN_HUMAN Utrophin (sprot)

A utrophin that is encoded in the genome of human.


name: IQGA1_HUMAN Ras GTPase-activating-like protein IQGAP1 (sprot)

description: A Ras GTPase-activating-like protein IQGAP1 that is encoded in the genome of human.


name: negative regulation of dephosphorylation

description: Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule.


name: 3HAO_HUMAN 3-hydroxyanthranilate 3,4-dioxygenase (sprot)

description: A 3-hydroxyanthranilate 3,4-dioxygenase that is encoded in the genome of human.


description: Catalysis of the reaction: 3-hydroxyanthranilate + O2 = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H+.


GLYG_HUMAN Glycogenin-1 (sprot)

A glycogenin-1 that is encoded in the genome of human.


name: STT3A_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (sprot)

description: A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A that is encoded in the genome of human.


co-translational protein modification

description: The process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome.


oligosaccharyltransferase III complex

description: An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma and the tetrameric TRAP complex. Of the three forms of mammalian OST complexes identified, the OSTIII complex has the strongest affinity for ribosomes.


name: GALR1_HUMAN Galanin receptor type 1 (sprot)

description: A galanin receptor type 1 that is encoded in the genome of human.


name: MSS4_HUMAN Guanine nucleotide exchange factor MSS4 (sprot)

description: A guanine nucleotide exchange factor MSS4 that is encoded in the genome of human.


CASA1_HUMAN Alpha-S1-casein (sprot)

An alpha-S1-casein that is encoded in the genome of human.


name: PA24A_HUMAN Cytosolic phospholipase A2 (sprot)

description: A cytosolic phospholipase A2 that is encoded in the genome of human.


O-acyltransferase activity

description: Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.


ceramide 1-phosphate binding

description: Binding to ceramide 1-phosphate.


name: platelet activating factor biosynthetic process

description: The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli.


phosphatidylglycerol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.


name: RPGP1_HUMAN Rap1 GTPase-activating protein 1 (sprot)

description: A Rap1 GTPase-activating protein 1 that is encoded in the genome of human.


name: negative regulation of microvillus assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly.


name: negative regulation of thyroid gland epithelial cell proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of thyroid gland epithelial cell proliferation.


name: CAZA2_HUMAN F-actin-capping protein subunit alpha-2 (sprot)

description: An F-actin-capping protein subunit alpha-2 that is encoded in the genome of human.


name: CAPZB_HUMAN F-actin-capping protein subunit beta (sprot)

description: An F-actin-capping protein subunit beta that is encoded in the genome of human.


name: GPR12_HUMAN G-protein coupled receptor 12 (sprot)

description: A G-protein coupled receptor 12 that is encoded in the genome of human.


name: RGR_HUMAN RPE-retinal G protein-coupled receptor (sprot)

description: An RPE-retinal G protein-coupled receptor that is encoded in the genome of human.


name: IF1AX_HUMAN Eukaryotic translation initiation factor 1A, X-chromosomal (sprot)

description: A eukaryotic translation initiation factor 1A, X-chromosomal that is encoded in the genome of human.


name: GBRA2_HUMAN Gamma-aminobutyric acid receptor subunit alpha-2 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-2 that is encoded in the genome of human.


name: GBRB2_HUMAN Gamma-aminobutyric acid receptor subunit beta-2 (sprot)

description: A gamma-aminobutyric acid receptor subunit beta-2 that is encoded in the genome of human.


GLR_HUMAN Glucagon receptor (sprot)

A glucagon receptor that is encoded in the genome of human.


glucagon receptor activity

description: Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


SCTR_HUMAN Secretin receptor (sprot)

A secretin receptor that is encoded in the genome of human.


secretin receptor activity

description: Combining with secretin to initiate a change in cell activity.


name: OMP_HUMAN Olfactory marker protein (sprot)

description: An olfactory marker protein that is encoded in the genome of human.


name: OR3A1_HUMAN Olfactory receptor 3A1 (sprot)

description: An olfactory receptor 3A1 that is encoded in the genome of human.


name: OR3A4_HUMAN Putative olfactory receptor 3A4 (sprot)

description: A putative olfactory receptor 3A4 that is encoded in the genome of human.


name: OR1D4_HUMAN Olfactory receptor 1D4 (sprot)

description: An olfactory receptor 1D4 that is encoded in the genome of human.


name: OR1E2_HUMAN Olfactory receptor 1E2 (sprot)

description: An olfactory receptor 1E2 that is encoded in the genome of human.


name: OR3A3_HUMAN Olfactory receptor 3A3 (sprot)

description: An olfactory receptor 3A3 that is encoded in the genome of human.


name: OR1G1_HUMAN Olfactory receptor 1G1 (sprot)

description: An olfactory receptor 1G1 that is encoded in the genome of human.


name: OR3A2_HUMAN Olfactory receptor 3A2 (sprot)

description: An olfactory receptor 3A2 that is encoded in the genome of human.


name: AL1A3_HUMAN Retinaldehyde dehydrogenase 3 (sprot)

description: A retinaldehyde dehydrogenase 3 that is encoded in the genome of human.


name: optic cup morphogenesis involved in camera-type eye development

description: The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.


nucleus accumbens development

description: The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia.


olfactory pit development

description: The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx.


name: SYQ_HUMAN Glutamine--tRNA ligase (sprot)

description: A glutamine--tRNA ligase that is encoded in the genome of human.


glutamine-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).


glutaminyl-tRNA aminoacylation

description: The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


name: 5HT5A_HUMAN 5-hydroxytryptamine receptor 5A (sprot)

description: A 5-hydroxytryptamine receptor 5A that is encoded in the genome of human.


P2RY1_HUMAN P2Y purinoceptor 1 (sprot)

A P2Y purinoceptor 1 that is encoded in the genome of human.


G protein-coupled ADP receptor activity

description: Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


G protein-coupled ATP receptor activity

description: Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


relaxation of muscle

description: A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain.


name: V1BR_HUMAN Vasopressin V1b receptor (sprot)

description: A vasopressin V1b receptor that is encoded in the genome of human.


name: CDX1_HUMAN Homeobox protein CDX-1 (sprot)

description: A homeobox protein CDX-1 that is encoded in the genome of human.


name: RL29_HUMAN Large ribosomal subunit protein eL29 (sprot)

description: A large ribosomal subunit protein eL29 that is encoded in the genome of human.


name: ID4_HUMAN DNA-binding protein inhibitor ID-4 (sprot)

description: A DNA-binding protein inhibitor ID-4 that is encoded in the genome of human.


prostate gland stromal morphogenesis

description: The process in which the prostate gland stroma is generated and organized. The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland.


seminal vesicle morphogenesis

description: The process in which the anatomical structures of a seminal vesicle are generated and organized.


LEG7_HUMAN Galectin-7 (sprot)

A galectin-7 that is encoded in the genome of human.


MT4_HUMAN Metallothionein-4 (sprot)

A metallothionein-4 that is encoded in the genome of human.


name: NPTX2_HUMAN Neuronal pentraxin-2 (sprot)

description: A neuronal pentraxin-2 that is encoded in the genome of human.


name: TISD_HUMAN mRNA decay activator protein ZFP36L2 (sprot)

description: An mRNA decay activator protein ZFP36L2 that is encoded in the genome of human.


name: negative regulation of mitotic cell cycle phase transition

description: Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition.


name: UCRI_HUMAN Cytochrome b-c1 complex subunit Rieske, mitochondrial (sprot)

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial that is encoded in the genome of human.


name: XDH_HUMAN Xanthine dehydrogenase/oxidase (sprot)

description: A xanthine dehydrogenase/oxidase that is encoded in the genome of human.


xanthine dehydrogenase activity

description: Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.


xanthine oxidase activity

description: Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide.


molybdopterin cofactor binding

description: Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.


hypoxanthine dehydrogenase activity

description: Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+.


hypoxanthine oxidase activity

description: Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2.


guanine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.


deoxyguanosine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose.


hypoxanthine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate.


xanthine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.


dGMP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate).


negative regulation of vasculogenesis

description: Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis.


XCL1_HUMAN Lymphotactin (sprot)

A lymphotactin that is encoded in the genome of human.


mature natural killer cell chemotaxis

description: The directed movement of a mature natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). A mature natural killer cell is a natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class and other stress related molecules.


name: positive regulation of granzyme B production

description: Any process that activates or increases the frequency, rate, or extent of production of granzyme B.


name: positive regulation of granzyme A production

description: Any process that activates or increases the frequency, rate or extent of granzyme A production.