nervous system development

description: The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.


positive regulation of neurogenesis

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.


name: positive regulation of neural precursor cell proliferation

description: Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.


spindle pole

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.


name: S22AK_HUMAN Solute carrier family 22 member 20 (sprot)

description: A solute carrier family 22 member 20 that is encoded in the genome of human.


name: PCX2_HUMAN Pecanex-like protein 2 (sprot)

description: A pecanex-like protein 2 that is encoded in the genome of human.


name: TSPY2_HUMAN Testis-specific Y-encoded protein 2 (sprot)

description: A testis-specific Y-encoded protein 2 that is encoded in the genome of human.


name: CC85C_HUMAN Coiled-coil domain-containing protein 85C (sprot)

description: A coiled-coil domain-containing protein 85C that is encoded in the genome of human.


cerebral cortex development

description: The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.


adherens junction

description: A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.


bicellular tight junction

description: An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.


apical junction complex

description: A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.


name: SAC31_HUMAN SAC3 domain-containing protein 1 (sprot)

description: A SAC3 domain-containing protein 1 that is encoded in the genome of human.


name: ARI3C_HUMAN AT-rich interactive domain-containing protein 3C (sprot)

description: An AT-rich interactive domain-containing protein 3C that is encoded in the genome of human.


membrane raft

description: Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.


name: RTL1_HUMAN Retrotransposon-like protein 1 (sprot)

description: A retrotransposon-like protein 1 that is encoded in the genome of human.


name: RL37L_HUMAN Putative ribosomal protein eL43-like (sprot)


name: OR5H1_HUMAN Olfactory receptor 5H1 (sprot)

description: An olfactory receptor 5H1 that is encoded in the genome of human.


name: T200C_HUMAN Transmembrane protein 200C (sprot)

description: A transmembrane protein 200C that is encoded in the genome of human.


name: D42E2_HUMAN Putative short-chain dehydrogenase/reductase family 42E member 2 (sprot)

description: A putative short-chain dehydrogenase/reductase family 42E member 2 that is encoded in the genome of human.


name: 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H+. Also acts on on 3-beta-hydroxypregn-5-en-20-one to form progesterone.


steroid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.


name: CGB1_HUMAN Choriogonadotropin subunit beta variant 1 (sprot)

description: A choriogonadotropin subunit beta variant 1 that is encoded in the genome of human.


hormone activity

description: The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.


name: SHL2B_HUMAN Protein shisa-like-2B (sprot)

description: A protein shisa-like-2B that is encoded in the genome of human.


name: S22AV_HUMAN Putative solute carrier family 22 member 31 (sprot)

description: A putative solute carrier family 22 member 31 that is encoded in the genome of human.


F74A7_HUMAN Protein FAM74A7 (sprot)

A protein FAM74A7 that is encoded in the genome of human.


name: O6C75_HUMAN Olfactory receptor 6C75 (sprot)

description: An olfactory receptor 6C75 that is encoded in the genome of human.


name: O5B21_HUMAN Olfactory receptor 5B21 (sprot)

description: An olfactory receptor 5B21 that is encoded in the genome of human.


name: CF144_HUMAN Cilia- and flagella-associated protein 144 (sprot)

description: A cilia- and flagella-associated protein 144 that is encoded in the genome of human.


SHSA7_HUMAN Protein shisa-7 (sprot)

A protein shisa-7 that is encoded in the genome of human.


ionotropic glutamate receptor binding

description: Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.


name: regulation of AMPA glutamate receptor clustering

description: Any process that modulates the frequency, rate or extent of AMPA glutamate receptor clustering.


regulation of AMPA receptor activity

description: Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity.


glutamatergic synapse

description: A synapse that uses glutamate as a neurotransmitter.


name: asymmetric, glutamatergic, excitatory synapse

description: A neuron to neuron synapse with a postsynaptic density, that uses glutamate as a neurotransmitter and whose activity results in excitatory postsynaptic potentials.


AMPA glutamate receptor complex

description: An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus.


GABA receptor binding

description: Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.


name: gamma-aminobutyric acid signaling pathway

description: The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell.


memory

description: The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).


name: gamma-aminobutyric acid receptor clustering

description: The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane.


regulation of GABA-A receptor activity

description: Any process that modulates the frequency, rate or extent of GABA-A receptor activity.


name: positive regulation of long-term synaptic potentiation

description: Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation.


postsynaptic density

description: An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.


postsynaptic density membrane

description: The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.


name: AQP73_HUMAN Putative aquaporin-7-like protein 3 (sprot)


name: CC070_HUMAN UPF0524 protein C3orf70 (sprot)

description: A UPF0524 protein C3orf70 that is encoded in the genome of human.


circadian behavior

description: The specific behavior of an organism that recurs with a regularity of approximately 24 hours.


name: TFKL2_HUMAN TATA-box binding protein associated factor 11 like protein 2 (sprot)

description: A protein that is a translation product of the TAF11L2 gene in human.


name: SIM23_HUMAN Small integral membrane protein 23 (sprot)

description: A small integral membrane protein 23 that is encoded in the genome of human.


name: TR64C_HUMAN Tripartite motif-containing protein 64C (sprot)

description: A protein that is a translation product of the TRIM64C gene in human.


name: C2C4B_HUMAN C2 calcium-dependent domain-containing protein 4B (sprot)

description: A C2 calcium-dependent domain-containing protein 4B that is encoded in the genome of human.


name: regulation of vascular permeability involved in acute inflammatory response

description: Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response.


name: positive regulation of acute inflammatory response

description: Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.


regulation of cell adhesion

description: Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.


name: TTC36_HUMAN Tetratricopeptide repeat protein 36 (sprot)

description: A tetratricopeptide repeat protein 36 that is encoded in the genome of human.


tyrosine metabolic process

description: The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.


visual learning

description: Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.


name: negative regulation of peptidyl-threonine phosphorylation

description: Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.


name: central nervous system neuron development

description: The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.


name: negative regulation of proteasomal ubiquitin-dependent protein catabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


name: negative regulation of protein polyubiquitination

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein polyubiquitination.


name: RFPLA_HUMAN Ret finger protein-like 4A (sprot)

description: A ret finger protein-like 4A that is encoded in the genome of human.


name: DUXA_HUMAN Double homeobox protein A (sprot)

description: A double homeobox protein A that is encoded in the genome of human.


SPDE4_HUMAN Speedy protein E4 (sprot)

A speedy protein E4 that is encoded in the genome of human.


name: TM210_HUMAN Transmembrane protein 210 (sprot)

description: A transmembrane protein 210 that is encoded in the genome of human.


name: O2AG2_HUMAN Olfactory receptor 2AG2 (sprot)

description: An olfactory receptor 2AG2 that is encoded in the genome of human.


AQ12B_HUMAN Aquaporin-12B (sprot)

An aquaporin-12B that is encoded in the genome of human.


water channel activity

description: Enables the energy-independent facilitated diffusion of water through a transmembrane aqueous pore or channel.


water transport

description: The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: L37A2_HUMAN Leucine-rich repeat-containing protein 37A2 (sprot)

description: A leucine-rich repeat-containing protein 37A2 that is encoded in the genome of human.


name: ZFP92_HUMAN Zinc finger protein 92 homolog (sprot)

description: A zinc finger protein 92 homolog that is encoded in the genome of human.


name: TCPQL_HUMAN Putative T-complex protein 1 subunit theta-like 1 (sprot)


ATP-dependent protein folding chaperone

description: Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.


name: O6C76_HUMAN Olfactory receptor 6C76 (sprot)

description: An olfactory receptor 6C76 that is encoded in the genome of human.


name: SIG16_HUMAN Sialic acid-binding Ig-like lectin 16 (sprot)

description: A sialic acid-binding Ig-like lectin 16 that is encoded in the genome of human.


name: positive regulation of defense response to bacterium

description: Any process that activates or increases the frequency, rate or extent of defense response to bacterium.


name: FIGL2_HUMAN Fidgetin-like protein 2 (sprot)

description: A protein that is a translation product of the FIGNL2 gene in human.


morphogenesis of a branching structure

description: The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.


negative regulation of cell migration

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.


name: negative regulation of axon regeneration

description: Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.


microtubule severing

description: The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends.


name: negative regulation of wound healing, spreading of epidermal cells

description: Any process that stops, prevents or reduces the frequency, rate or extent of wound healing, spreading of epidermal cells.


name: CPS4L_HUMAN Putative cleavage and polyadenylation specificity factor subunit 4-like protein (sprot)

description: A putative cleavage and polyadenylation specificity factor subunit 4-like protein that is encoded in the genome of human.


name: TM212_HUMAN Transmembrane protein 212 (sprot)

description: A transmembrane protein 212 that is encoded in the genome of human.


F170B_HUMAN Protein FAM170B (sprot)

A protein FAM170B that is encoded in the genome of human.


regulation of fertilization

description: Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).


outer acrosomal membrane

description: The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction.


name: OR5K4_HUMAN Olfactory receptor 5K4 (sprot)

description: An olfactory receptor 5K4 that is encoded in the genome of human.


name: L37A1_HUMAN Leucine-rich repeat-containing protein 37A (sprot)

description: A leucine-rich repeat-containing protein 37A that is encoded in the genome of human.


name: DBX1_HUMAN Homeobox protein DBX1 (sprot)

description: A homeobox protein DBX1 that is encoded in the genome of human.


name: ventral spinal cord interneuron specification

description: The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway.


name: O52A4_HUMAN Olfactory receptor 52A4 (sprot)

description: A protein that is a translation product of the OR52A4P gene in human.


name: I4E1B_HUMAN Eukaryotic translation initiation factor 4E type 1B (sprot)

description: A eukaryotic translation initiation factor 4E type 1B that is encoded in the genome of human.


regulation of translation

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.


name: AXA2L_HUMAN Putative annexin A2-like protein (sprot)

description: A protein that is a translation product of the ANXA2P2 gene in human.


melanosome

description: A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.


SNTAN_HUMAN Sentan (sprot)

A sentan that is encoded in the genome of human.


transition metal ion binding

description: Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.


name: O4C45_HUMAN Olfactory receptor 4C45 (sprot)

description: An olfactory receptor 4C45 that is encoded in the genome of human.


name: CO6A6_HUMAN Collagen alpha-6(VI) chain (sprot)

description: A collagen alpha-6(VI) chain that is encoded in the genome of human.


name: extracellular matrix structural constituent conferring tensile strength

description: A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.


extracellular matrix

description: A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.


name: ZN729_HUMAN Zinc finger protein 729 (sprot)

description: A zinc finger protein 729 that is encoded in the genome of human.


name: CXE1_HUMAN Putative gap junction epsilon-1 protein (sprot)

description: A putative gap junction epsilon-1 protein that is encoded in the genome of human.


cell morphogenesis

description: The developmental process in which the size or shape of a cell is generated and organized.


lens development in camera-type eye

description: The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.


organ growth

description: The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.


name: SRRM3_HUMAN Serine/arginine repetitive matrix protein 3 (sprot)

description: A serine/arginine repetitive matrix protein 3 that is encoded in the genome of human.


name: DRGX_HUMAN Dorsal root ganglia homeobox protein (sprot)

description: A dorsal root ganglia homeobox protein that is encoded in the genome of human.


neuron migration

description: The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.


detection of chemical stimulus

description: The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal.


detection of temperature stimulus

description: The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal.


trigeminal nerve development

description: The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.


name: sensory perception of mechanical stimulus

description: The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


name: IFM5_HUMAN Interferon-induced transmembrane protein 5 (sprot)

description: An interferon-induced transmembrane protein 5 that is encoded in the genome of human.


bone mineralization

description: The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.


regulation of bone mineralization

description: Any process that modulates the frequency, rate or extent of bone mineralization.


bone morphogenesis

description: The process in which bones are generated and organized.


name: P12LL_HUMAN Putative POM121-like protein 1-like (sprot)


name: O2AT4_HUMAN Olfactory receptor 2AT4 (sprot)

description: An olfactory receptor 2AT4 that is encoded in the genome of human.


olfactory receptor activity

description: Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.


name: positive regulation of ERK1 and ERK2 cascade

description: Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.


name: MARHB_HUMAN E3 ubiquitin-protein ligase MARCHF11 (sprot)

description: An E3 ubiquitin-protein ligase MARCHF11 that is encoded in the genome of human.


cytoplasmic vesicle membrane

description: The lipid bilayer surrounding a cytoplasmic vesicle.


name: ZN726_HUMAN Zinc finger protein 726 (sprot)

description: A zinc finger protein 726 that is encoded in the genome of human.


name: CO061_HUMAN Uncharacterized protein C15orf61 (sprot)

description: An uncharacterized protein C15orf61 that is encoded in the genome of human.


name: RIM3B_HUMAN RIMS-binding protein 3B (sprot)

description: A RIMS-binding protein 3B that is encoded in the genome of human.


name: TTL13_HUMAN Tubulin polyglutamylase TTLL13 (sprot)

description: A tubulin polyglutamylase Ttll13 that is encoded in the genome of human.


tubulin-glutamic acid ligase activity

description: Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.


protein modification process

description: The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).


name: S38A8_HUMAN Solute carrier family 38 member 8 (sprot)

description: A solute carrier family 38 member 8 that is encoded in the genome of human.


name: L-alpha-amino acid transmembrane transport

description: The directed movement of L-alpha-amino acid across a membrane by means of some agent such as a transporter or a pore.


name: DRS7C_HUMAN Dehydrogenase/reductase SDR family member 7C (sprot)

description: A dehydrogenase/reductase SDR family member 7C that is encoded in the genome of human.


name: all-trans-retinol dehydrogenase (NAD+) activity

description: Catalysis of the reaction: all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADH. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.


intracellular calcium ion homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell.


name: regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

description: Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.


glucose import

description: The directed movement of the hexose monosaccharide glucose into a cell or organelle.


longitudinal sarcoplasmic reticulum

description: The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae.


sarcoplasmic reticulum membrane

description: The lipid bilayer surrounding the sarcoplasmic reticulum.


ENO4_HUMAN Enolase 4 (sprot)

An enolase 4 that is encoded in the genome of human.


glycolytic process

description: The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.


name: UBP27_HUMAN Ubiquitin carboxyl-terminal hydrolase 27 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 27 that is encoded in the genome of human.


cysteine-type endopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


cysteine-type deubiquitinase activity

description: An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.


K63-linked deubiquitinase activity

description: Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys63 residue of ubiquitin.


K48-linked deubiquitinase activity

description: Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin.


protein deubiquitination

description: The removal of one or more ubiquitin groups from a protein.


protein K63-linked deubiquitination

description: A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein.


protein K48-linked deubiquitination

description: A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein.


TBB8B_HUMAN Tubulin beta 8B (sprot)

A tubulin that is a translation product of the TUBB8B gene in human.


intercellular bridge

description: A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.


name: ZN716_HUMAN Zinc finger protein 716 (sprot)

description: A zinc finger protein 716 that is encoded in the genome of human.


ZAR1L_HUMAN Protein ZAR1-like (sprot)

A protein ZAR1-like that is encoded in the genome of human.


oocyte maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.


description: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.


name: TTLL8_HUMAN Protein monoglycylase TTLL8 (sprot)

description: A protein monoglycylase TTLL8 that is encoded in the genome of human.


protein-glycine ligase activity

description: Catalysis of the reaction: ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L-glutamyl-[protein] + H+ + phosphate.


name: protein-glycine ligase activity, initiating

description: Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein.


protein polyglycylation

description: The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid.


sperm flagellum

description: A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.


name: NCB2L_HUMAN Nuclear cap-binding protein subunit 2-like (sprot)

description: A nuclear cap-binding protein subunit 2-like that is encoded in the genome of human.


mRNA cis splicing, via spliceosome

description: The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.


name: LRIQ3_HUMAN Leucine-rich repeat and IQ domain-containing protein 3 (sprot)

description: A leucine-rich repeat and IQ domain-containing protein 3 that is encoded in the genome of human.


name: ABTB3_HUMAN Ankyrin repeat and BTB/POZ domain-containing protein 3 (sprot)

description: An ankyrin repeat and BTB/POZ domain-containing protein 3 that is encoded in the genome of human.


PDZ domain binding

description: Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.


synaptic transmission, glutamatergic

description: The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


exploration behavior

description: The specific behavior of an organism in response to a novel environment or stimulus.


name: YJEN3_HUMAN YjeF N-terminal domain-containing protein 3 (sprot)

description: A YjeF N-terminal domain-containing protein 3 that is encoded in the genome of human.


regulation of Notch signaling pathway

description: Any process that modulates the frequency, rate or extent of the Notch signaling pathway.


regulation of cholesterol efflux

description: Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.


negative regulation of angiogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.


membrane raft distribution

description: The process that establishes the spatial arrangement of membrane rafts within a cellular membrane.


hematopoietic stem cell proliferation

description: The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.


name: RTL8C_HUMAN Retrotransposon Gag-like protein 8C (sprot)

description: An RTL8C gene translation product (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A6ZKI3.


name: GOG8A_HUMAN Golgin subfamily A member 8A (sprot)

description: A golgin subfamily A member 8A that is encoded in the genome of human.


name: CFA96_HUMAN Cilia-and flagella-associated protein 96 (sprot)

description: A cilia-and flagella-associated protein 96 that is encoded in the genome of human.


cytoplasmic microtubule

description: Any microtubule in the cytoplasm of a cell.


9+0 non-motile cilium

description: A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme).


name: ZSWM8_HUMAN Zinc finger SWIM domain-containing protein 8 (sprot)

description: A zinc finger SWIM domain-containing protein 8 that is encoded in the genome of human.


name: ubiquitin-like ligase-substrate adaptor activity

description: The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins.


name: proteasome-mediated ubiquitin-dependent protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


target-directed miRNA degradation

description: The process in which a miRNA is targeted for degradation by a non-coding RNA or mRNA. The binding of an RNA to a target miRNA within a RISC complex results in either ubiquitin-mediated degradation of AGO protein or the displacement of the 3' end of the miRNA, exposing it to nucleases.


name: positive regulation of miRNA catabolic process

description: Any process that activates or increases the frequency, rate or extent of miRNA catabolic process.


Cul3-RING ubiquitin ligase complex

description: A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.


MYH7B_HUMAN Myosin-7B (sprot)

A myosin-7B that is encoded in the genome of human.


name: RHG32_HUMAN Rho GTPase-activating protein 32 (sprot)

description: A rho/Cdc42/Rac GTPase-activating protein RICS that is encoded in the genome of human.


phosphatidylinositol phosphate binding

description: Binding to phosphatidylinositol phosphate.


name: DISP2_HUMAN Protein dispatched homolog 2 (sprot)

description: A protein dispatched homolog 2 that is encoded in the genome of human.


name: TBKB1_HUMAN TANK-binding kinase 1-binding protein 1 (sprot)

description: A TANK-binding kinase 1-binding protein 1 that is encoded in the genome of human.


name: type I interferon-mediated signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by type I interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


serine/threonine protein kinase complex

description: A protein complex which is capable of protein serine/threonine kinase activity.


name: SRRM4_HUMAN Serine/arginine repetitive matrix protein 4 (sprot)

description: A serine/arginine repetitive matrix protein 4 that is encoded in the genome of human.


mRNA binding

description: Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.


regulation of RNA splicing

description: Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.


name: SOBP_HUMAN Sine oculis-binding protein homolog (sprot)

description: A sine oculis-binding protein that is encoded in the genome of human.


SUMO polymer binding

description: Binding to a polymer of the small ubiquitin-like protein SUMO.


cognition

description: The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.


cochlea development

description: The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.


name: P121C_HUMAN Nuclear envelope pore membrane protein POM 121C (sprot)

description: A nuclear envelope pore membrane protein POM 121C that is encoded in the genome of human.


nuclear envelope

description: The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).


name: CF176_HUMAN Putative transcriptional regulator encoded by LINC00473 (sprot)


DNA-templated transcription

description: The synthesis of an RNA transcript from a DNA template.


name: ZN839_HUMAN Zinc finger protein 839 (sprot)

description: A zinc finger protein 839 that is encoded in the genome of human.


name: WASH1_HUMAN WASH complex subunit 1 (sprot)

description: A WASH complex subunit 1 that is encoded in the genome of human.


exocyst

description: A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.


alpha-tubulin binding

description: Binding to the microtubule constituent protein alpha-tubulin.


exocytosis

description: A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.


negative regulation of autophagy

description: Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.


endosomal transport

description: The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.


name: positive regulation of pseudopodium assembly

description: Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia.


regulation of protein ubiquitination

description: Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein.


endocytic recycling

description: The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.


name: Arp2/3 complex-mediated actin nucleation

description: The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.


name: regulation of Arp2/3 complex-mediated actin nucleation

description: Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins.


retrograde transport, endosome to Golgi

description: The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.


late endosome

description: A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.


autophagosome

description: A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.


recycling endosome

description: An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.


recycling endosome membrane

description: The lipid bilayer surrounding a recycling endosome.


WASH complex

description: A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53.


name: A2ML1_HUMAN Alpha-2-macroglobulin-like protein 1 (sprot)

description: An alpha-2-macroglobulin-like protein 1 that is encoded in the genome of human.


name: serine-type endopeptidase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase.


regulation of endopeptidase activity

description: Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.


name: CLM7_HUMAN CMRF35-like molecule 7 (sprot)

description: A CMRF35-like molecule 7 that is encoded in the genome of human.


immune system process

description: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.


name: CO062_HUMAN Uncharacterized protein C15orf62, mitochondrial (sprot)

description: An uncharacterized protein C15orf62 homolog, mitochondrial that is encoded in the genome of human.


name: CLCA1_HUMAN Calcium-activated chloride channel regulator 1 (sprot)

description: A calcium-activated chloride channel regulator 1 that is encoded in the genome of human.


chloride channel activity

description: Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel.


calcium ion transport

description: The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


cellular response to hypoxia

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.


zymogen granule membrane

description: The lipid bilayer surrounding a zymogen granule.


name: OCAT2_HUMAN POU class 2 homeobox associating factor 3 (sprot)

description: A protein that is a translation product of the POU2AF3 gene in human.


transcription coactivator activity

description: A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.


POU domain binding

description: Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors.


name: EFCB7_HUMAN EF-hand calcium-binding domain-containing protein 7 (sprot)

description: An EF-hand calcium-binding domain-containing protein 7 that is encoded in the genome of human.


name: regulation of smoothened signaling pathway

description: Any process that modulates the frequency, rate or extent of smoothened signaling.


name: positive regulation of protein import into nucleus

description: Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.


protein localization to motile cilium

description: A process in which a protein is transported to, or maintained in, a location within a motile cilium.


name: positive regulation of protein localization to ciliary membrane

description: Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane.


ciliary membrane

description: The portion of the plasma membrane surrounding a cilium.


SFI1_HUMAN Protein SFI1 homolog (sprot)

A protein SFI1 that is encoded in the genome of human.


phosphatase binding

description: Binding to a phosphatase.


name: ZN785_HUMAN Zinc finger protein 785 (sprot)

description: A zinc finger protein 785 that is encoded in the genome of human.


name: ERI2_HUMAN ERI1 exoribonuclease 2 (sprot)

description: An ERI1 exoribonuclease 2 that is encoded in the genome of human.


name: D11L8_HUMAN Putative ATP-dependent RNA helicase DDX11-like protein 8 (sprot)

description: A putative ATP-dependent RNA helicase DDX11-like protein 8 that is encoded in the genome of human.


RNA helicase activity

description: Unwinding of an RNA helix, driven by ATP hydrolysis.


DNA metabolic process

description: Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.


name: YDJC_HUMAN Carbohydrate deacetylase (sprot)

description: A carbohydrate deacetylase that is encoded in the genome of human.


carbohydrate metabolic process

description: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.


name: PP2D1_HUMAN Protein phosphatase 2C-like domain-containing protein 1 (sprot)

description: A protein phosphatase 2C-like domain-containing protein 1 that is encoded in the genome of human.


name: protein serine/threonine phosphatase activity

description: Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.


name: GBRR3_HUMAN Gamma-aminobutyric acid receptor subunit rho-3 (sprot)

description: A gamma-aminobutyric acid receptor subunit rho-3 that is encoded in the genome of human.


GABA-A receptor activity

description: Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.


name: GABA-gated chloride ion channel activity

description: Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts.


chemical synaptic transmission

description: The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


chloride channel complex

description: An ion channel complex through which chloride ions pass.


name: CRTP1_HUMAN Cysteine-rich tail protein 1 (sprot)

description: A cysteine-rich tail protein 1 that is encoded in the genome of human.


name: biological process involved in interaction with symbiont

description: An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.


establishment of skin barrier

description: Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.


cornified envelope

description: A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes).


name: PM2P5_HUMAN Postmeiotic segregation increased 2-like protein 5 (sprot)

description: A postmeiotic segregation increased 2-like protein 5 that is encoded in the genome of human.


name: ZN850_HUMAN Zinc finger protein 850 (sprot)

description: A zinc finger protein 850 that is encoded in the genome of human.


name: NEU1B_HUMAN E3 ubiquitin-protein ligase NEURL1B (sprot)

description: An E3 ubiquitin-protein ligase NEURL1B that is encoded in the genome of human.


Notch signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


ubiquitin-dependent endocytosis

description: Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded.


actin cytoskeleton

description: The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.


name: GOG8B_HUMAN Golgin subfamily A member 8B (sprot)

description: A golgin subfamily A member 8B that is encoded in the genome of human.


name: NPIB5_HUMAN Nuclear pore complex-interacting protein family member B5 (sprot)

description: A protein that is a translation product of the NPIPB5 gene in human.


name: SYC1L_HUMAN Synaptonemal complex central element protein 1-like (sprot)

description: A synaptonemal complex central element protein 1-like that is encoded in the genome of human.


intermediate filament cytoskeleton

description: Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.


name: ZN891_HUMAN Zinc finger protein 891 (sprot)

description: A zinc finger protein 891 that is encoded in the genome of human.


name: CENPX_HUMAN Centromere protein X (sprot)

description: A stimulated by retinoic acid gene 13 protein that is encoded in the genome of human.


double-stranded DNA binding

description: Binding to double-stranded DNA.


name: resolution of meiotic recombination intermediates

description: The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged.


chromosome segregation

description: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.


name: positive regulation of protein ubiquitination

description: Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.


interstrand cross-link repair

description: Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.


kinetochore assembly

description: The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.


inner kinetochore

description: The region of a kinetochore closest to centromeric DNA which contains many CENP proteins organized in various subcomplexes including CENP-C, CENP-LN, CENP-HIKM, CENP-OPQUR and CENP-TWSX, but excluding the CENP-A containing heterochromatin.


FANCM-MHF complex

description: A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes.


Fanconi anaemia nuclear complex

description: A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage.


name: ZBBX_HUMAN Zinc finger B-box domain-containing protein 1 (sprot)

description: A zinc finger B-box domain-containing protein 1 that is encoded in the genome of human.


name: CMI2B_HUMAN Ciliary microtubule inner protein 2B (sprot)

description: A ciliary microtubule inner protein 2B that is encoded in the genome of human.


name: GNAT3_HUMAN Guanine nucleotide-binding protein G(t) subunit alpha-3 (sprot)

description: A guanine nucleotide-binding protein G(t) subunit alpha-3 that is encoded in the genome of human.


response to nicotine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.


sensory perception of umami taste

description: The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process.


name: FOXI3_HUMAN Forkhead box protein I3 (sprot)

description: A forkhead box protein I3 that is encoded in the genome of human.


hair follicle development

description: The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.


epidermal cell fate specification

description: The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


thymus development

description: The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.


parathyroid gland development

description: The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone.


otic placode development

description: The process whose specific outcome is the progression of an otic placode over time, from its formation to the mature structure.


name: R212B_HUMAN RING finger protein 212B (sprot)

description: A RING finger protein 212B that is encoded in the genome of human.


name: HMSD_HUMAN Serpin-like protein HMSD (sprot)


activation of immune response

description: Any process that initiates an immune response.


name: NOTO_HUMAN Homeobox protein notochord (sprot)

description: A homeobox protein notochord that is encoded in the genome of human.


heart looping

description: The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceding septation.


embryonic pattern specification

description: The process that results in the patterns of cell differentiation that will arise in an embryo.


dorsal/ventral pattern formation

description: The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.


notochord development

description: The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.


motile cilium assembly

description: The aggregation, arrangement and bonding together of a set of components to form a motile cilium.


CEBOS_HUMAN Protein CEBPZOS (sprot)

A protein CEBPZOS that is encoded in the genome of human.


name: YB043_HUMAN Putative uncharacterized protein ENSP00000380674 (sprot)


name: ZN724_HUMAN Zinc finger protein 724 (sprot)

description: A protein that is a translation product of the ZNF724 gene in human.


name: KRA97_HUMAN Keratin-associated protein 9-7 (sprot)

description: A keratin-associated protein 9-7 that is encoded in the genome of human.


name: BBIP1_HUMAN BBSome-interacting protein 1 (sprot)

description: A BBSome-interacting protein 1 that is encoded in the genome of human.


eating behavior

description: The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.


BBSome

description: A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B.


name: SMTL1_HUMAN Smoothelin-like protein 1 (sprot)

description: A smoothelin-like protein 1 that is encoded in the genome of human.


calmodulin binding

description: Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.


tropomyosin binding

description: Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.


protein phosphatase 1 binding

description: Binding to a protein phosphatase 1.


CH domain binding

description: Binding to a calponin homology protein domain, a domain of 100 residues that occurs in signaling and cytoskeletal proteins.


disordered domain specific binding

description: Binding to a disordered domain of a protein.


response to xenobiotic stimulus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.


response to activity

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.


vasoconstriction

description: A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure.


positive regulation of vasoconstriction

description: Any process that activates or increases the frequency, rate or extent of vasoconstriction.


muscle organ morphogenesis

description: The process in which the anatomical structures of muscle are generated and organized.


M band

description: The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.


I band

description: A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.


contractile muscle fiber

description: Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.


name: U17L5_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 5 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 17-like protein 5 that is encoded in the genome of human.


LEG16_HUMAN Galectin-16 (sprot)

A galectin-16 that is encoded in the genome of human.


lactose binding

description: Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk.


name: positive regulation of T cell apoptotic process

description: Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process.


name: YQ048_HUMAN Putative uncharacterized protein ENSP00000381830 (sprot)


name: CSKMT_HUMAN Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial (sprot)

description: A citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial that is encoded in the genome of human.


lysine N-methyltransferase activity

description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue.


description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.


protein methylation

description: The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.


peptidyl-lysine trimethylation

description: The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine.


peptidyl-lysine monomethylation

description: The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine.


peptidyl-lysine dimethylation

description: The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.


name: ZN727_HUMAN Putative zinc finger protein 727 (sprot)

description: A protein that is a translation product of the ZNF727 gene in human.


name: KR161_HUMAN Keratin-associated protein 16-1 (sprot)

description: A keratin-associated protein 16-1 that is encoded in the genome of human.


name: Z705G_HUMAN Putative zinc finger protein 705G (sprot)

description: A putative zinc finger protein 705G that is encoded in the genome of human.


name: MPTX_HUMAN Putative mucosal pentraxin homolog (sprot)


name: HIG1C_HUMAN HIG1 domain family member 1C (sprot)

description: A HIG1 domain family member 1C that is encoded in the genome of human.


name: KRA96_HUMAN Keratin-associated protein 9-6 (sprot)

description: A keratin-associated protein 9-6 that is encoded in the genome of human.


HIDE1_HUMAN Protein HIDE1 (sprot)

A protein HIDE1 that is encoded in the genome of human.


name: NCF1C_HUMAN Putative neutrophil cytosol factor 1C (sprot)


F1712_HUMAN Protein FAM171A2 (sprot)

A protein FAM171A2 that is encoded in the genome of human.


name: HECA2_HUMAN HEPACAM family member 2 (sprot)

description: A HEPACAM family member 2 that is encoded in the genome of human.


centrosome cycle

description: The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.


name: ARG33_HUMAN Rho guanine nucleotide exchange factor 33 (sprot)

description: A Rho guanine nucleotide exchange factor 33 that is encoded in the genome of human.


name: P20L1_HUMAN PHD finger protein 20-like protein 1 (sprot)

description: A PHD finger protein 20-like protein 1 that is encoded in the genome of human.


methylation-dependent protein binding

description: Binding to a protein upon methylation of the target protein.


name: negative regulation of protein catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process.


BECN2_HUMAN Beclin-2 (sprot)

A beclin-2 that is encoded in the genome of human.


name: G protein-coupled receptor catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a G protein-coupled receptor.


name: MEI4_HUMAN Meiosis-specific protein MEI4 (sprot)

description: A meiosis-specific protein MEI4 that is encoded in the genome of human.


DNA recombination

description: Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.


name: homologous chromosome pairing at meiosis

description: The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete.


name: meiotic DNA double-strand break formation

description: The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination.


oogenesis

description: The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.


lateral element

description: A proteinaceous core found between sister chromatids during meiotic prophase.


name: Z705E_HUMAN Putative zinc finger protein 705EP (sprot)

description: A putative zinc finger protein 705EP that is encoded in the genome of human.


name: RUXGL_HUMAN Putative small nuclear ribonucleoprotein G-like protein 15 (sprot)


spliceosomal snRNP assembly

description: The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.


name: EFCB8_HUMAN EF-hand calcium-binding domain-containing protein 8 (sprot)

description: An EF-hand calcium-binding domain-containing protein 8 that is encoded in the genome of human.


name: FS2P1_HUMAN Putative fatty acid desaturase 2-like protein FADS2B (sprot)


name: SM34A_HUMAN Small integral membrane protein 34 (sprot)

description: A protein that is a translation product of the SMIM34 gene in human.


name: WASH4_HUMAN Putative WAS protein family homolog 4 (sprot)

description: A protein that is a translation product of the WASH4P gene in human.


name: ELAP2_HUMAN Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 (sprot)

description: An endosome/lysosome-associated apoptosis and autophagy regulator family member 2 that is a translation product of the ELAPOR2 gene in human.


BMP receptor binding

description: Binding to a BMP receptor.


name: positive regulation of BMP signaling pathway

description: Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.


name: positive regulation of epidermis development

description: Any process that activates or increases the frequency, rate or extent of epidermis development.


name: negative regulation of nervous system development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.


name: KR291_HUMAN Keratin-associated protein 29-1 (sprot)

description: A keratin-associated protein 29-1 that is encoded in the genome of human.


CAN14_HUMAN Calpain-14 (sprot)

A calpain-14 that is encoded in the genome of human.


name: GRCR1_HUMAN Glutaredoxin domain-containing cysteine-rich protein 1 (sprot)

description: A glutaredoxin domain-containing cysteine-rich protein 1 that is encoded in the genome of human.


name: inner ear auditory receptor cell differentiation

description: The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell.


vestibular receptor cell development

description: The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.


inner ear receptor cell development

description: The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.


name: inner ear receptor cell stereocilium organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells.


stereocilium

description: An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.


kinocilium

description: A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia.


name: B3GT9_HUMAN Beta-1,3-galactosyltransferase 9 (sprot)

description: A beta-1,3-galactosyltransferase 9 that is encoded in the genome of human.


hexosyltransferase activity

description: Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).


name: VSTM5_HUMAN V-set and transmembrane domain-containing protein 5 (sprot)

description: A V-set and transmembrane domain-containing protein 5 that is encoded in the genome of human.


ventral spinal cord development

description: The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output.


filopodium assembly

description: The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.


name: positive regulation of excitatory synapse assembly

description: Any process that activates or increases the frequency, rate or extent of excitatory synapse assembly.


dendrite

description: A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.


name: DB108_HUMAN Putative beta-defensin 108A (sprot)

description: A putative beta-defensin 108A that is encoded in the genome of human.


name: NUD19_HUMAN Acyl-coenzyme A diphosphatase NUDT19 (sprot)

description: An acyl-coenzyme A diphosphatase NUDT19 that is encoded in the genome of human.


fatty acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.


coenzyme A catabolic process

description: The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.


name: medium-chain fatty-acyl-CoA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.


butyryl-CoA catabolic process

description: The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA.


succinyl-CoA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of succinyl-CoA.


propionyl-CoA metabolic process

description: The chemical reactions and pathways involving propionyl-CoA.


malonyl-CoA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of malonyl-CoA, the S-malonyl derivative of coenzyme A.


peroxisomal matrix

description: The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.


name: CD15L_HUMAN CMT1A duplicated region transcript 15 protein-like protein (sprot)

description: A CMT1A duplicated region transcript 15 protein-like protein that is encoded in the genome of human.


name: ZNF99_HUMAN Zinc finger protein 99 (sprot)

description: A zinc finger protein 99 that is encoded in the genome of human.


name: KRA91_HUMAN Keratin-associated protein 9-1 (sprot)

description: A keratin-associated protein 9-1 that is encoded in the genome of human.


name: TMC5B_HUMAN Transmembrane and coiled-coil domain-containing protein 5B (sprot)

description: A transmembrane and coiled-coil domain-containing protein 5B that is encoded in the genome of human.


name: CMA1B_HUMAN Ciliary microtubule associated protein 1B (sprot)

description: A ciliary microtubule associated protein 1B that is encoded in the genome of human.


name: KCNU1_HUMAN Potassium channel subfamily U member 1 (sprot)

description: A potassium channel subfamily U member 1 that is encoded in the genome of human.


potassium channel activity

description: Enables the energy-independent facilitated diffusion of a potassium ion through a transmembrane aqueous pore or channel.


reproductive process

description: A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.


potassium ion transmembrane transport

description: A process in which a potassium ion is transported from one side of a membrane to the other.


monoatomic ion channel complex

description: A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective monoatomic ion transport down its electrochemical gradient.


name: DCD2C_HUMAN Doublecortin domain-containing protein 2C (sprot)

description: A doublecortin domain-containing protein 2C that is encoded in the genome of human.


name: MIY4B_HUMAN Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B (sprot)

description: An inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B that is encoded in the genome of human.


name: FOXO6_HUMAN Forkhead box protein O6 (sprot)

description: A forkhead box protein O6 that is encoded in the genome of human.


name: positive regulation of dendritic spine development

description: Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.


name: EFCB9_HUMAN EF-hand calcium-binding domain-containing protein 9 (sprot)

description: An EF-hand calcium-binding domain-containing protein 9 that is encoded in the genome of human.


calcium ion sensor activity

description: Binding to and responding, e.g. by conformational change, to changes in the cellular level of calcium ions (Ca2+).


sperm capacitation

description: A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.


CatSper complex

description: A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits.


name: EVPLL_HUMAN Envoplakin-like protein (sprot)

description: An envoplakin-like protein that is encoded in the genome of human.


name: intermediate filament cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins.


name: LEUTX_HUMAN Paired-like homeodomain transcription factor LEUTX (sprot)

description: A paired-like homeodomain transcription factor LEUTX that is encoded in the genome of human.


name: CB074_HUMAN Uncharacterized protein C2orf74 (sprot)

description: An uncharacterized protein C2orf74 that is encoded in the genome of human.


name: OOSP1_HUMAN Putative oocyte-secreted protein 1 homolog (sprot)


name: CO6A5_HUMAN Collagen alpha-5(VI) chain (sprot)

description: A collagen alpha-5(VI) chain that is encoded in the genome of human.


name: IMA8_HUMAN Importin subunit alpha-8 (sprot)

description: An importin subunit alpha-8 that is encoded in the genome of human.


blastocyst development

description: The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.


protein import into nucleus

description: The directed movement of a protein from the cytoplasm to the nucleus.


negative regulation of gene expression

description: Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).


name: epigenetic regulation of gene expression

description: A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal.


female germ cell nucleus

description: The nucleus of the female germ cell, a reproductive cell in females.


name: NLS-dependent protein nuclear import complex

description: A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore.


name: MI4GD_HUMAN MIF4G domain-containing protein (sprot)

description: A MIF4G domain-containing protein that is encoded in the genome of human.


cap-dependent translational initiation

description: The process where the cap structure, composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins, located at the 5' end of an mRNA molecule, which serves as a molecular tag that marks the spot where the 40S ribosomal subunit, is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.


positive regulation of translation

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.


histone mRNA stem-loop binding complex

description: A protein-containing complex composed of a stem-loop binding protein (in most species SLBP) and its interacting partner (SLIP1 or MIF4GD in most species) that binds to the histone mRNA (hmRNA) 3-prime-stem-loop structure. Facilitates hmRNA translation initiation and may also be involved in its processing and nuclear export.


name: AHRR_HUMAN Aryl hydrocarbon receptor repressor (sprot)

description: An aryl hydrocarbon receptor repressor that is encoded in the genome of human.


name: intracellular receptor signaling pathway

description: The series of molecular signals initiated by a ligand binding to a receptor located within a cell.


name: MYO1G_HUMAN Unconventional myosin-Ig (sprot)

description: A myosin-Ig that is encoded in the genome of human.


description: Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.


description: Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.


description: Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.


T cell mediated immunity

description: Any process involved in the carrying out of an immune response by a T cell.


cell-substrate adhesion

description: The attachment of a cell to the underlying substrate via adhesion molecules.


name: Fc-gamma receptor signaling pathway involved in phagocytosis

description: An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.


cell gliding

description: Cell motility that results in the smooth movement of a cell along a solid surface.


T cell migration

description: The movement of a T cell within or between different tissues and organs of the body.


T cell meandering migration

description: The random-like motility observed for T cells in lymph nodes which enhances surveillance of antigens presented by major histocompatibility complex (MHC) molecules on antigen presenting cells (APCs).


leading edge membrane

description: The portion of the plasma membrane surrounding the leading edge of a motile cell.


myosin complex

description: A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.


name: DESPR_HUMAN Dual endothelin-1/VEGF signal peptide receptor (sprot)

description: A protein that is a translation product of the FBXW7-AS1 gene in human.


endothelin receptor activity

description: Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


name: vascular endothelial growth factor binding

description: Binding to a vascular endothelial growth factor.


name: vascular endothelial growth factor signaling pathway

description: The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


endothelin receptor signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: HACD1_HUMAN Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 (sprot)

description: A very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 that is encoded in the genome of human.


3-hydroxyacyl-CoA dehydratase activity

description: Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O.


name: very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity

description: Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA = H2O + a very-long-chain (2E)-enoyl-CoA. This reaction is the third (dehydration) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit.


ESPN_HUMAN Espin (sprot)

An espin that is encoded in the genome of human.


SH3 domain binding

description: Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.


microvillar actin bundle assembly

description: Assembly of the parallel bundle of actin filaments at the core of a microvillus.


brush border

description: The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.


stereocilium tip

description: A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation.


filamentous actin

description: A two-stranded helical polymer of the protein actin.


ISM1_HUMAN Isthmin-1 (sprot)

An isthmin-1 that is encoded in the genome of human.


name: NALF1_HUMAN NALCN channel auxiliary factor 1 (sprot)

description: A NALCN channel auxiliary factor 1 that is encoded in the genome of human.


name: ZN487_HUMAN Putative zinc finger protein 487 (sprot)

description: A putative zinc finger protein 487 that is encoded in the genome of human.


name: PRR32_HUMAN Proline-rich protein 32 (sprot)

description: A proline-rich protein 32 that is encoded in the genome of human.


KILIN_HUMAN Killin (sprot)

A killin that is encoded in the genome of human.


name: MR1L2_HUMAN MORF4 family associated protein 1 like 2 (sprot)

description: A protein that is a translation product of the MRFAP1L2 gene in human.


name: R10B2_HUMAN Radial spoke head 10 homolog B2 (sprot)

description: A radial spoke head 10 homolog B2 that is encoded in the genome of human.


9+2 motile cilium

description: A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).


name: CENP1_HUMAN Putative CENPB DNA-binding domain-containing protein 1 (sprot)

description: A putative CENPB DNA-binding domain-containing protein 1 that is encoded in the genome of human.


name: O11HC_HUMAN Olfactory receptor 11H12 (sprot)

description: An olfactory receptor 11H12 that is encoded in the genome of human.


name: C1T9B_HUMAN Complement C1q and tumor necrosis factor-related protein 9B (sprot)

description: A complement C1q and tumor necrosis factor-related protein 9B that is encoded in the genome of human.


name: HGB1A_HUMAN Putative high mobility group protein B1-like 1 (sprot)


name: MYO9A_HUMAN Unconventional myosin-IXa (sprot)

description: A myosin-IXa that is encoded in the genome of human.


cell junction assembly

description: A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.


name: establishment of epithelial cell apical/basal polarity

description: The specification and formation of the apicobasal polarity of an epithelial cell.


name: regulation of neuron projection arborization

description: Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches.


unconventional myosin complex

description: A portmanteau term for myosins other than myosin II.


name: VWC2L_HUMAN von Willebrand factor C domain-containing protein 2-like (sprot)

description: A von Willebrand factor C domain-containing protein 2-like that is encoded in the genome of human.


name: SMIM1_HUMAN Small integral membrane protein 1 (sprot)

description: A small integral membrane protein 1 that is encoded in the genome of human.


name: CF97D_HUMAN Sperm axonemal maintenance protein CFAP97D1 (sprot)

description: A sperm axonemal maintenance protein CFAP97D1 that is encoded in the genome of human.


name: T229A_HUMAN Transmembrane protein 229A (sprot)

description: A transmembrane protein 229A that is encoded in the genome of human.


name: ZBT42_HUMAN Zinc finger and BTB domain-containing protein 42 (sprot)

description: A zinc finger and BTB domain-containing protein 42 that is encoded in the genome of human.


name: KDM4E_HUMAN Lysine-specific demethylase 4E (sprot)

description: A lysine-specific demethylase 4E that is encoded in the genome of human.


name: histone H3K9me2/H3K9me3 demethylase activity

description: Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


name: BTBDI_HUMAN BTB/POZ domain-containing protein 18 (sprot)

description: A BTB/POZ domain-containing protein 18 that is encoded in the genome of human.


retrotransposon silencing

description: Any process that decreases the frequency, rate or extent of retrotransposition. Retrotransposons are a subset of transposable elements that use an RNA intermediate and reverse transcribe themselves into the genome.


male meiosis I

description: A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline.


piRNA transcription

description: The cellular synthesis of Piwi-interacting RNA piRNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.


name: HNRC2_HUMAN Heterogeneous nuclear ribonucleoprotein C-like 2 (sprot)

description: A protein that is a translation product of the HNRNPCL2 gene in human.


ribonucleoprotein complex

description: A macromolecular complex that contains both RNA and protein molecules.


positive regulation of macroautophagy

description: Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.


negative regulation of TOR signaling

description: Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.


FM25C_HUMAN Protein FAM25C (sprot)

A protein FAM25C that is encoded in the genome of human.


name: PATE3_HUMAN Prostate and testis expressed protein 3 (sprot)

description: A prostate and testis expressed protein 3 that is encoded in the genome of human.


name: IQIP1_HUMAN IQCJ-SCHIP1 readthrough transcript protein (sprot)

description: An IQCJ-SCHIP1 readthrough transcript protein that is encoded in the genome of human.


name: negative regulation of cytoskeleton organization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.


axon initial segment

description: Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.


name: TM114_HUMAN Transmembrane protein 114 (sprot)

description: A transmembrane protein 114 that is encoded in the genome of human.


apicolateral plasma membrane

description: The apical end of the lateral plasma membrane of epithelial cells.


name: NBPFP_HUMAN Neuroblastoma breakpoint family member 26 (sprot)


name: TM233_HUMAN Transmembrane protein 233 (sprot)

description: A transmembrane protein 233 that is encoded in the genome of human.


SHSA9_HUMAN Protein shisa-9 (sprot)

A protein shisa-9 that is encoded in the genome of human.