vitamin A import into cell

description: The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid.


name: ACBD4_HUMAN Acyl-CoA-binding domain-containing protein 4 (sprot)

description: An acyl-CoA-binding domain-containing protein 4 that is encoded in the genome of human.


ubiquinone-6 biosynthetic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways resulting in the formation of ubiquinone-6.


polyprenol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans.


name: PAL4F_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4F (sprot)

description: A protein that is a translation product of the PPIAL4F gene in human.


metabolite repair

description: A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites.


RNA polymerase III core binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.


mitotic DNA replication

description: Any nuclear DNA replication that is involved in a mitotic cell cycle.


D5 dopamine receptor binding

description: Binding to a D5 dopamine receptor.


TRAPPI protein complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A complex that tethers COPII vesicles at ER-Golgi intermediate compartment. Its role in this part of the vesicular transport may start at the ER exit sites. Binds to a component of the COPII coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33 which are regarded as the core subunits of all TRAPP complexes in yeast.


name: KCP_HUMAN Kielin/chordin-like protein (sprot)

description: A cysteine-rich motor neuron 2 protein that is encoded in the genome of human.


name: P3URF_HUMAN PIK3R3 upstream open reading frame protein (sprot)

description: A PIK3R3 upstream open reading frame protein that is encoded in the genome of human.


fatty acid synthase activity

description: Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.


name: CH088_HUMAN Uncharacterized protein C8orf88 (sprot)

description: A protein that is a translation product of the C8orf88 gene in human.


priRNA 3'-end processing

description: The process of forming the mature 3' end of a priRNA molecule.


name: clathrin-dependent synaptic vesicle endocytosis

description: Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds.


name: purine-specific nucleoside:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in).


dUDP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate).


substance P receptor binding

description: Binding to a substance P receptor.


name: peptidyl-histidine methylation, to form tele-methylhistidine

description: The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine).


name: EX3L4_HUMAN Exocyst complex component 3-like protein 4 (sprot)

description: An exocyst complex component 3-like protein 4 that is encoded in the genome of human.


name: leucine-rich repeat-containing protein 29 (human)

description: A leucine-rich repeat-containing protein 29 that is encoded in the genome of human.


exopolyphosphatase activity

description: Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate.


mu-type opioid receptor binding

description: Binding to a mu-type opioid receptor.


name: negative regulation of RNA catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process.


name: NPS3B_HUMAN Protein NipSnap homolog 3B (sprot)

description: A protein NipSnap homolog 3B that is encoded in the genome of human.


name: regulation of plasma membrane sterol distribution

description: Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane.


striated muscle dense body

description: A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.


name: regulation of integrin biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.


name: kainate selective glutamate receptor complex

description: An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits.


Sec62/Sec63 complex

description: A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p.


name: A0A0G2JN68_HUMAN Killer cell immunoglobulin-like receptor 2DL5B (trembl)


eRF1 methyltransferase complex

description: A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p.


response to dehydroepiandrosterone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus.


messenger ribonucleoprotein complex

description: A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules.


description: Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate.


meiotic joint molecule formation

description: The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA.


CCNI2_HUMAN Cyclin-I2 (sprot)

A cyclin-I2 that is encoded in the genome of human.


name: negative regulation of sequestering of calcium ion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.


tRNA import into mitochondrion

description: The process in which a tRNA is transported from the cytosol into the mitochondrial matrix.


name: chromosome localization to nuclear envelope involved in homologous chromosome segregation

description: The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis.


name: NBEL1_HUMAN Neurobeachin-like protein 1 (sprot)

description: A neurobeachin-like protein 1 that is encoded in the genome of human.


telomere localization

description: Any process in which a telomere is transported to, and/or maintained in, a specific location.


thiosulfate transport

description: The directed movement of thiosulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


MutLalpha complex

description: A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.


cone matrix sheath

description: A biochemically and structurally distinct domain of the retinal interphotoreceptor matrix that is specifically associated with cone photoreceptor cell inner and outer segments.


name: PONL1_HUMAN Podocan-like protein 1 (sprot)

description: A podocan-like protein 1 that is encoded in the genome of human.


name: TM9S3_HUMAN Transmembrane 9 superfamily member 3 (sprot)

description: A transmembrane 9 superfamily member 3 that is encoded in the genome of human.


neural fold bending

description: The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse.


name: nucleoside diphosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.


description: Catalysis of the reaction: a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA.


name: S35G4_HUMAN Putative solute carrier family 35 member G4 (sprot)

description: A putative solute carrier family 35 member G4 that is encoded in the genome of human.


name: somatic recombination of immunoglobulin genes involved in immune response

description: The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response.


plasma membrane region

description: A membrane that is a (regional) part of the plasma membrane.


name: NUA4L_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 that is encoded in the genome of human.


Ral protein signal transduction

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An intracellular signaling cassette in which a small monomeric GTPase of the RaI subfamily relays a signal.


NADHX epimerase activity

description: Catalysis of the reaction: (R)-NADHX = (S)-NADHX.


name: regulation of arginine metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.


U1 snRNA 3'-end processing

description: Any process involved in forming the mature 3' end of a U1 snRNA molecule.


name: mitochondrial DNA-directed RNA polymerase complex

description: A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form.


Set3 complex

description: A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p.


name: group II metabotropic glutamate receptor activity

description: A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity.


name: positive regulation of anaphase-promoting complex-dependent catabolic process

description: Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.


name: SG1D4_HUMAN Secretoglobin family 1D member 4 (sprot)

description: A secretoglobin family 1D member 4 that is encoded in the genome of human.


mitotic cell cycle checkpoint signaling

description: A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.


name: transcription open complex formation at RNA polymerase II promoter

description: Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.


name: PGBD2_HUMAN PiggyBac transposable element-derived protein 2 (sprot)

description: A piggyBac transposable element-derived protein 2 that is encoded in the genome of human.


microtubule plus end polymerase

description: Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversible depending on the availability of dimers.


interleukin-33 binding

description: Binding to interleukin-33.


description: A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces.


name: LRC27_HUMAN Leucine-rich repeat-containing protein 27 (sprot)

description: A leucine-rich repeat-containing protein 27 that is encoded in the genome of human.


name: LHPL7_HUMAN LHFPL tetraspan subfamily member 7 protein (sprot)

description: An LHFPL tetraspan subfamily member 7 protein that is encoded in the genome of human.


name: heterotrimeric G-protein complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a heterotrimeric G-protein complex.


name: tRNA threonylcarbamoyladenosine metabolic process

description: The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.


name: PLPR3_HUMAN Phospholipid phosphatase-related protein type 3 (sprot)

description: A phospholipid phosphatase-related protein type 3 that is encoded in the genome of human.


phosphoglycerate dehydrogenase activity

description: Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.


description: The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


parathyroid hormone receptor binding

description: Binding to a parathyroid hormone receptor.


name: M4A15_HUMAN Membrane-spanning 4-domains subfamily A member 15 (sprot)

description: A membrane-spanning 4-domains subfamily A member 15 that is encoded in the genome of human.


cysteinyl leukotriene receptor activity

description: Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine.


acylphosphatase activity

description: Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate.


maintenance of ER location

description: Any process in which the endoplasmic reticulum is maintained in a specific location within a cell and prevented from moving elsewhere.


alpha-amino acid metabolic process

description: The chemical reactions and pathways involving an alpha-amino acid.


tRNA re-export from nucleus

description: The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export.


oxytocin receptor activity

description: Combining with oxytocin to initiate a change in cell activity.


SPE2B_HUMAN Speedy protein E2B (sprot)

A protein that is a translation product of the SPDYE2B gene in human.


sphinganine metabolic process

description: The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol.


name: TIGD2_HUMAN Tigger transposable element-derived protein 2 (sprot)

description: A tigger transposable element-derived protein 2 that is encoded in the genome of human.


sarcosine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of sarcosine.


translation reinitiation

description: A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.


name: A0A0G2JPC4_HUMAN Killer cell immunoglobulin-like receptor (trembl)


name: acireductone dioxygenase [iron(II)-requiring] activity

description: Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-methylthio-2-oxobutanoate + formate + H+.


Golgi vesicle docking

description: The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane.


CDP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate.


name: negative regulation of cytoplasmic translational initiation in response to stress

description: Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress.


determination of ventral identity

description: The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


description: Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.


name: nuclear polyadenylation-dependent antisense transcript catabolic process

description: The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript.


name: tRNA wobble adenosine to inosine editing

description: The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine.


name: negative regulation of gastric acid secretion

description: Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.


name: nickel cation transmembrane transporter activity

description: Enables the transfer of nickel (Ni) cations from one side of a membrane to the other.


name: BT2A3_HUMAN Putative butyrophilin subfamily 2 member A3 (sprot)


NHSL1_HUMAN NHS-like protein 1 (sprot)

An NHS-like protein 1 that is encoded in the genome of human.


description: Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA.


name: ACL10_HUMAN Actin-like protein 10 (sprot)

description: An actin-like protein 10 that is encoded in the genome of human.


name: DCBD1_HUMAN Discoidin, CUB and LCCL domain-containing protein 1 (sprot)

description: A discoidin, CUB and LCCL domain-containing protein 1 that is encoded in the genome of human.


name: establishment of sister chromatid cohesion

description: The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase.


name: GOG6B_HUMAN Golgin subfamily A member 6B (sprot)

description: A protein that is a translation product of the GOLGA6B gene in human.


guanine deaminase activity

description: Catalysis of the reaction: guanine + H2O = xanthine + NH3.


interleukin-9 binding

description: Binding to interleukin-9.


name: UPKL2_HUMAN Uroplakin-3b-like protein 2 (sprot)

description: A protein that is a translation product of the UPK3BL2 gene in human.


sucrose biosynthetic process

description: The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside.


SNG4_HUMAN Synaptogyrin-4 (sprot)

A synaptogyrin-4 that is encoded in the genome of human.


DMXL1_HUMAN DmX-like protein 1 (sprot)

A DmX-like protein 1 that is encoded in the genome of human.


catenin-TCF7L2 complex

description: A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.


description: Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.


name: CA5BL_HUMAN Putative inactive carbonic anhydrase 5B-like protein (sprot)


name: NKG2F_HUMAN NKG2-F type II integral membrane protein (sprot)

description: An NKG2-F type II integral membrane protein that is encoded in the genome of human.


meiotic spindle midzone

description: The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap.


transcription factor TFIIE complex

description: A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH.


deoxynucleoside kinase activity

description: Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate.


name: regulation of glucosylceramidase activity

description: Any process that modulates the frequency, rate or extent of glucosylceramidase activity.


name: plasma membrane proton-transporting V-type ATPase complex

description: A proton-transporting two-sector ATPase complex found in the plasma membrane.


GLPE_HUMAN Glycophorin-E (sprot)

A glycophorin-E that is encoded in the genome of human.


nuclear migration along microtubule

description: The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.


name: TCRGL_HUMAN Transcription elongation regulator 1-like protein (sprot)

description: A transcription elongation regulator 1-like protein that is encoded in the genome of human.


name: SH2D7_HUMAN SH2 domain-containing protein 7 (sprot)

description: An SH2 domain-containing protein 7 that is encoded in the genome of human.


name: CO040_HUMAN UPF0235 protein C15orf40 (sprot)

description: A UPF0235 protein C15orf40 that is encoded in the genome of human.


description: Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O.


RRP15_HUMAN RRP15-like protein (sprot)

An RRP15-like protein that is encoded in the genome of human.


medium-chain fatty acid transport

description: The directed movement of a medium-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.


name: D-lactate dehydrogenase (cytochrome) activity

description: Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.


name: cytosolic tRNA wobble base thiouridylase complex

description: A complex of two proteins involved in the thiolation of uridine 34 (U34) of tRNAs decoding two-family box triplets.


name: 3'-tRNA processing endoribonuclease activity

description: Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.


description: Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.


name: CCD82_HUMAN Coiled-coil domain-containing protein 82 (sprot)

description: A coiled-coil domain-containing protein 82 that is encoded in the genome of human.


tRNA N2-guanine methylation

description: The process whereby a guanine in a tRNA is methylated at the N2 position of guanine.


succinate-CoA ligase complex

description: A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP.


name: MAGE2_HUMAN Melanoma-associated antigen E2 (sprot)

description: A melanoma-associated antigen E2 that is encoded in the genome of human.


name: mitotic DNA replication preinitiation complex assembly

description: Any DNA replication preinitiation complex assembly that is involved in mitotic cell cycle.


FA53A_HUMAN Protein FAM53A (sprot)

A protein FAM53A that is encoded in the genome of human.


system development

description: The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.


adenine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.


dCMP deaminase activity

description: Catalysis of the reaction: dCMP + H2O = dUMP + NH3.


farnesyl diphosphate metabolic process

description: The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation.


name: TM14D_HUMAN Transmembrane protein 14DP (sprot)

description: A transmembrane protein 14DP that is encoded in the genome of human.


type 2 orexin receptor binding

description: Binding to a type 2 orexin receptor.


name: MAGBH_HUMAN Melanoma-associated antigen B17 (sprot)


palmitoyl-CoA 9-desaturase activity

description: Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O.


apelin receptor activity

description: Combining with the peptide apelin to initiate a change in cell activity.


name: GOG8H_HUMAN Golgin subfamily A member 8H (sprot)

description: A golgin subfamily A member 8H that is encoded in the genome of human.


name: UDP-galactose transmembrane import into Golgi lumen

description: The directed movement of UDP-galactose into the Golgi lumen across the Golgi membrane.


description: Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage.


mitochondrial seryl-tRNA aminoacylation

description: The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


description: A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M.


sperm individualization

description: The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane.


name: mitochondrial double-strand break repair via homologous recombination

description: The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences.


F135A_HUMAN Protein FAM135A (sprot)

A protein FAM135A that is encoded in the genome of human.


description: Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A).


name: corticotropin-releasing hormone receptor activity

description: Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity.


name: UDP-N-acetylgalactosamine transmembrane transporter activity

description: Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


name: MRGRG_HUMAN Mas-related G-protein coupled receptor member G (sprot)

description: A Mas-related G-protein coupled receptor G that is encoded in the genome of human.


name: GLCI1_HUMAN Glucocorticoid-induced transcript 1 protein (sprot)

description: A glucocorticoid-induced transcript 1 protein that is encoded in the genome of human.


glyoxalase III activity

description: Catalysis of the reaction: methylglyoxal + H2O = D-lactate.


name: RAB42_HUMAN Ras-related protein Rab-42 (sprot)

description: A Ras-related protein Rab-42 that is encoded in the genome of human.


description: The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues.


oocyte axis specification

description: The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.


name: HDGL1_HUMAN Hepatoma-derived growth factor-like protein 1 (sprot)

description: A hepatoma-derived growth factor-like protein 1 that is encoded in the genome of human.


name: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.


tyrosine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.


uracil binding

description: Binding to uracil.


name: microtubule nucleation by interphase microtubule organizing center

description: The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation.


Gtr1-Gtr2 GTPase complex

description: A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins.


description: Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H+.


adenine/guanine mispair binding

description: Binding to a double-stranded DNA region containing an A/G mispair.


name: immunoglobulin production involved in immunoglobulin-mediated immune response

description: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.


name: phosphatidylinositol 3-kinase complex, class III, type I

description: A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p.


name: SAM10_HUMAN Sterile alpha motif domain-containing protein 10 (sprot)

description: A sterile alpha motif domain-containing protein 10 that is encoded in the genome of human.


name: synapse assembly involved in innervation

description: The assembly of a synapse within a target tissue in which a nerve is invading.


name: positive regulation of mitotic recombination

description: Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis.


name: regulation of microtubule depolymerization

description: Any process that modulates the frequency, rate or extent of microtubule depolymerization.


name: KANK3_HUMAN KN motif and ankyrin repeat domain-containing protein 3 (sprot)

description: A KN motif and ankyrin repeat domain-containing protein 3 that is encoded in the genome of human.


name: propionate metabolic process, methylmalonyl pathway

description: The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway.


name: SWT1_HUMAN Transcriptional protein SWT1 (sprot)

description: A transcriptional protein SWT1 that is encoded in the genome of human.


sarcosine metabolic process

description: The chemical reactions and pathways involving sarcosine.


name: A0A075B7D4_HUMAN Immunoglobulin kappa variable 1/OR2-108 (non-functional) (Fragment) (trembl)


description: Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine.


vacuole fusion, non-autophagic

description: The fusion of two vacuole membranes to form a single vacuole.


saccharopine dehydrogenase activity

description: Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor.


name: UBA1L_HUMAN Ubiquitin-associated protein 1-like (sprot)

description: A ubiquitin-associated protein 1-like that is encoded in the genome of human.


name: KI2LA_HUMAN Killer cell immunoglobulin-like receptor 2DL5A (sprot)

description: A killer cell immunoglobulin-like receptor 2DL5A that is encoded in the genome of human.


name: regulation of Rho guanyl-nucleotide exchange factor activity

description: Any process that modulates the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.


name: nucleotide-excision repair, DNA damage recognition

description: The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix.


name: prolactin-releasing peptide receptor binding

description: Binding to a prolactin-releasing peptide receptor.


name: LBHD1_HUMAN LBH domain-containing protein 1 (sprot)

description: A protein that is a translation product of the LBHD1 gene in human.


name: TM14E_HUMAN Transmembrane protein 14EP (sprot)

description: A transmembrane protein 14EP that is encoded in the genome of human.


description: Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate.


lytic vacuole

description: A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.


STPG3_HUMAN Protein STPG3 (sprot)

A protein STPG3 that is encoded in the genome of human.


name: SPD8_HUMAN Putative speedy protein E8 (sprot)


maturation of 5S rRNA

description: Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule.


SPDE5_HUMAN Speedy protein E5 (sprot)

A protein that is a translation product of the SPDYE5 gene in human.


N-terminal peptidyl-alanine methylation

description: The methylation of the N-terminal alanine of proteins.


adenine salvage

description: Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis.


name: regulation of guanylate cyclase activity

description: Any process that modulates the frequency, rate or extent of guanylate cyclase activity.


name: LRC30_HUMAN Leucine-rich repeat-containing protein 30 (sprot)

description: A leucine-rich repeat-containing protein 30 that is encoded in the genome of human.


WFD11_HUMAN Protein WFDC11 (sprot)

A protein WFDC11 that is encoded in the genome of human.


taste receptor binding

description: Binding to a taste receptor.


name: intermediate conductance calcium-activated potassium channel activity

description: Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.


name: adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation

description: An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation.


amidophosphoribosyltransferase activity

description: Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O.


leukotriene B4 receptor activity

description: Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate.


name: CLUL1_HUMAN Clusterin-like protein 1 (sprot)

description: A clusterin-like protein 1 that is encoded in the genome of human.


name: SPD13_HUMAN Putative speedy protein E13 (sprot)


thyrotropin-releasing hormone activity

description: The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.


description: Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O.


name: farnesyl diphosphate biosynthetic process, mevalonate pathway

description: The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols.


name: GRIN3_HUMAN G protein-regulated inducer of neurite outgrowth 3 (sprot)

description: A G protein-regulated inducer of neurite outgrowth 3 that is encoded in the genome of human.


name: MAGB1_HUMAN Melanoma-associated antigen B1 (sprot)

description: A melanoma-associated antigen B1 that is encoded in the genome of human.


name: AN34C_HUMAN Ankyrin repeat domain-containing protein 34C (sprot)

description: An ankyrin repeat domain-containing protein 34C that is encoded in the genome of human.


acid-amino acid ligase activity

description: Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.


name: A0A3B3IRQ3_HUMAN Uncharacterized protein (trembl)


name: cyclic pyranopterin monophosphate synthase activity

description: Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.


D-ribulokinase activity

description: Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate.


negative cofactor 2 complex

description: A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.


name: LR75A_HUMAN Leucine-rich repeat-containing protein 75A (sprot)

description: A leucine-rich repeat-containing protein 75A that is encoded in the genome of human.


name: A0A0G2JP20_HUMAN PRAME family member 9 (trembl)


name: meiotic spindle assembly checkpoint signaling

description: A signal transduction process that contributes to a meiotic spindle assembly checkpoint, that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle.


cell cycle

description: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.


name: cysteine biosynthetic process from serine

description: The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine.


glutathione synthase activity

description: Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate.


name: MA13P_HUMAN Putative MAGE domain-containing protein MAGEA13P (sprot)


name: calcium activated phospholipid scrambling

description: The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.


name: single-stranded DNA exodeoxyribonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule.


bent DNA binding

description: Binding to DNA in a bent conformation.


name: GAL3A_HUMAN Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial (sprot)

description: A glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial that is encoded in the genome of human.


name: proton-transporting ATP synthase complex, catalytic core F(1)

description: The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled.


Rad6-Rad18 complex

description: A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity.


name: CRIS2_HUMAN Cysteine-rich secretory protein 2 (sprot)

description: A cysteine-rich secretory protein 2 that is encoded in the genome of human.


3'-nucleotidase activity

description: Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.


oxytocin receptor binding

description: Binding to an oxytocin receptor.


DNA replication termination

description: The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet.


negative regulation of GTP binding

description: Any process that stops, prevents or reduces the frequency, rate or extent of GTP binding.


TSN11_HUMAN Tetraspanin-11 (sprot)

A tetraspanin-11 that is encoded in the genome of human.


D-ribose metabolic process

description: The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12.


L-leucine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of L-leucine, 2-amino-4-methylpentanoic acid.


interleukin-9 receptor binding

description: Binding to an interleukin-9 receptor.


name: double-stranded DNA endonuclease activity

description: Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks.


name: A0A0C4DH90_HUMAN Immunoglobulin kappa variable 3/OR2-268 (non-functional) (Fragment) (trembl)


male meiosis cytokinesis

description: A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells.


dihydroorotate dehydrogenase activity

description: Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.


name: AMERL_HUMAN AMMECR1-like protein (sprot)

description: An AMMECR1-like protein that is encoded in the genome of human.


name: Okazaki fragment processing involved in mitotic DNA replication

description: Any DNA replication, Okazaki fragment processing that is involved in mitotic cell cycle DNA replication.


threonine deaminase activity

description: Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH4.


cytoplasmic translational termination

description: The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.


name: mannose-1-phosphate guanylyltransferase (GTP) activity

description: Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose.


name: cytokine production involved in immune response

description: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.


name: LRC53_HUMAN Leucine-rich repeat-containing protein 53 (sprot)

description: A protein that is a translation product of the LRRC53 gene in human.


steroid 7-alpha-hydroxylase activity

description: Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O.


NAD salvage

description: Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam).


name: SH2D6_HUMAN SH2 domain-containing protein 6 (sprot)

description: An SH2 domain-containing protein 6 that is encoded in the genome of human.


adenine binding

description: Binding to adenine, a purine base.


name: ABRAL_HUMAN Costars family protein ABRACL (sprot)

description: A costars family protein ABRACL that is encoded in the genome of human.


name: TV23C_HUMAN Golgi apparatus membrane protein TVP23 homolog C (sprot)

description: A Golgi apparatus membrane protein TVP23 homolog C that is encoded in the genome of human.


name: nucleotide-excision repair factor 3 complex

description: One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p).


dermatan sulfate metabolic process

description: The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues.


name: clathrin-dependent endocytosis of virus by host cell

description: Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus.


name: G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

description: A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane.


Sm-like protein family complex

description: A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles.


D4 dopamine receptor binding

description: Binding to a D4 dopamine receptor.


name: FB5L3_HUMAN Putative fatty acid-binding protein 5-like protein 3 (sprot)


Rpd3L-Expanded complex

description: A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins.


aspartyl-tRNA aminoacylation

description: The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an aspartic acid accetping tRNA.


name: RA1L3_HUMAN Heterogeneous nuclear ribonucleoprotein A1-like 3 (sprot)

description: A protein that is a translation product of the HNRNPA1L3 gene in human.


name: GS1L2_HUMAN Germ cell-specific gene 1-like protein 2 (sprot)

description: A protein that is a translation product of the GSG1L2 gene in human.


name: hepatocyte growth factor receptor activity

description: Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.


name: nuclear polyadenylation-dependent CUT catabolic process

description: The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT.


arginine catabolic process to glutamate

description: The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate.


name: protein localization to ciliary inversin compartment

description: A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment.


NADPH-adrenodoxin reductase activity

description: Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.


butyrate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid.


name: OSER1_HUMAN Oxidative stress-responsive serine-rich protein 1 (sprot)

description: An oxidative stress-responsive serine-rich protein 1 that is encoded in the genome of human.


name: S14L6_HUMAN Putative SEC14-like protein 6 (sprot)


TRC complex

description: A protein complex found in yeast that contains GET4, MDY2 (GET5), SGT2, and at least two heat shock proteins, HSP104 and YBR137W. The TRC complex transfers tail-anchored (TA) proteins to GET3 for targeting to the endoplasmic reticulum membrane.


postsynaptic early endosome

description: An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling.


name: DNA recombinase auxiliary factor complex

description: A protein complex that binds to a recombinase and incrseases its activity.


name: tryptophan catabolic process to acetyl-CoA

description: The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA.


name: RNA polymerase III preinitiation complex assembly

description: The formation of a large multiprotein-DNA complex that self-assembles on a tRNA gene through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC), (which includes BDP1, BRF1, TBP, TFIIIC in human). The PIC engages RNA polymerase III on its DNA template strand and sparks polymerization of the first few RNA nucleotides.


U2 snRNA 3'-end processing

description: Any process involved in forming the mature 3' end of a U2 snRNA molecule.


name: rRNA cytidine N-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA.


description: Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)).


name: A0A3B3IRS2_HUMAN Uncharacterized protein (trembl)


structural constituent of synapse

description: The action of a molecule that contributes to the structural integrity of a synapse.


D-xylose catabolic process

description: The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide.


description: Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide.


presynaptic cytoskeleton

description: The portion of the cytoskeleton contained within the presynapse.


protein O-GlcNAcylation via threonine

description: The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine.


name: UPK3L_HUMAN Uroplakin-3b-like protein 1 (sprot)

description: A uroplakin-3b-like protein 1 that is encoded in the genome of human.


RNA polymerase III assembly

description: The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase III complex.


SPD16_HUMAN Speedy protein E16 (sprot)

A protein that is a translation product of the SPDYE16 gene in human.


name: ATP synthesis coupled electron transport

description: The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.


adenosine kinase activity

description: Catalysis of the reaction: ATP + adenosine = ADP + AMP.


name: regulation of nervous system development

description: Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.


alkylbase DNA N-glycosylase activity

description: Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site.


name: MROH5_HUMAN Maestro heat-like repeat family member 5 (sprot)


RNA transmembrane transporter activity

description: Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other.


name: SH24B_HUMAN SH2 domain-containing protein 4B (sprot)

description: An SH2 domain-containing protein 4B that is encoded in the genome of human.


nuclear protein-containing complex

description: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.


peptidyl-aspartic acid hydroxylation

description: The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid.


name: LRIQ4_HUMAN Leucine-rich repeat and IQ domain-containing protein 4 (sprot)

description: A leucine-rich repeat and IQ domain-containing protein 4 that is encoded in the genome of human.


Ssh1 translocon complex

description: A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences.


post-spliceosomal complex

description: A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5.


name: SCP2D_HUMAN SCP2 sterol-binding domain-containing protein 1 (sprot)

description: An SCP2 sterol-binding domain-containing protein 1 that is encoded in the genome of human.


name: mitochondrial tRNA wobble uridine modification

description: The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified.


quinolinate metabolic process

description: The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.


name: maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II

description: Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter.


dUTP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate.


brassinosteroid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects.


DNA ligase III-XRCC1 complex

description: A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair.


NHSL3_HUMAN NHS-like protein 3 (sprot)

An NHS-like protein 3 that is encoded in the genome of human.


name: glucosamine 6-phosphate N-acetyltransferase activity

description: Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+.


lateral element assembly

description: The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements.


name: SPDE7_HUMAN Putative speedy protein E7 (sprot)


N-terminal peptidyl-proline methylation

description: The methylation of the N-terminal proline of proteins.


name: MAB6B_HUMAN Melanoma-associated antigen B6B (sprot)

description: A protein that is a translation product of the MAGEB6B gene in human.


name: nucleotide-excision repair, preincision complex assembly

description: The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage.


name: M4A18_HUMAN Membrane-spanning 4-domains subfamily A member 18 (sprot)

description: A membrane-spanning 4-domains subfamily A member 18 that is encoded in the genome of human.


carotenoid dioxygenase activity

description: Catalysis of the oxidative cleavage of carotenoids.


microtubule-based transport

description: A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.


T cell tolerance induction

description: A process involving any mechanism for tolerance induction in T cells.


name: trans-synaptic signaling by neuropeptide, modulating synaptic transmission

description: Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.


regulation of heterochromatin formation

description: Any process that modulates the frequency, rate, extent or location of heterochromatin formation.


name: SPD9_HUMAN Putative speedy protein E9 (sprot)


GKN3_HUMAN Gastrokine-3 (sprot)

A protein that is a translation product of the GKN3P gene in human.


name: mitochondrial coenzyme A transmembrane transport

description: The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion.


IgE receptor activity

description: Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


melanocortin receptor binding

description: Binding to a melanocortin receptor.


description: Catalysis of the reaction: a (3R)-hydroxyacyl-[acyl-carrier-protein] = a (2E)-enoyl-[acyl-carrier-protein] + H2O.


name: IQCF6_HUMAN IQ domain-containing protein F6 (sprot)

description: A protein that is a translation product of the IQCF6 gene in human.


dTDP-glucose 4,6-dehydratase activity

description: Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.


transverse filament

description: A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them.


type 1 orexin receptor binding

description: Binding to a type 1 orexin receptor.


laminin complex

description: A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes.


rixosome complex

description: A conserved RNA endonuclease complex required for spreading and epigenetic inheritance of heterochromatin. The rixosome contains six unique subunits: three structural subunits (Crb3, Rix1, and Ipi1) which form the core of the complex, and three catalytic subunits (the endonuclease Las1, the polynucleotide kinase Grc3, and the AAA-type ATPase Mdn1), which are involved in the processing of ribosomal RNA precursors. All subunits are essential for viability and are conserved from yeast to mammals, including humans.


nuclear pore transmembrane ring

description: A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex.


name: TM202_HUMAN Transmembrane protein 202 (sprot)

description: A transmembrane protein 202 that is encoded in the genome of human.


kisspeptin receptor binding

description: Binding to a kisspeptin receptor.


name: radial glia guided migration of cerebellar granule cell

description: The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer.


substance K receptor activity

description: Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity.


CXCR4 chemokine receptor binding

description: Binding to a CXCR4 chemokine receptor.


RNA polymerase I assembly

description: The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase I complex.


snoRNA splicing

description: The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA.


galanin receptor binding

description: Binding to a galanin receptor.


description: Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP.


growth hormone receptor activity

description: Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: double-strand break repair via single-strand annealing

description: Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats.


name: IFM10_HUMAN Interferon-induced transmembrane protein 10 (sprot)

description: An interferon-induced transmembrane protein 10 that is encoded in the genome of human.


name: A0A087WZ39_HUMAN T cell receptor beta variable 15 (Fragment) (trembl)


name: thyrotropin-releasing hormone receptor activity

description: Combining with thyrotropin-releasing hormone to initiate a change in cell activity.


name: peptidyl-proline hydroxylation to 3-hydroxy-L-proline

description: The modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase.


name: arginine catabolic process to proline via ornithine

description: The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine.


description: Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O.


name: assembly of large subunit precursor of preribosome

description: The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome.


name: 23S rRNA (adenine(1618)-N(6))-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA.


U2-type post-spliceosomal complex

description: A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U2 and U6.


name: SPD21_HUMAN Putative speedy protein E21 (sprot)


name: RELD1_HUMAN Reelin domain-containing protein 1 (sprot)

description: A protein that is a translation product of the REELD1 gene in human.


name: DPPA5_HUMAN Developmental pluripotency-associated 5 protein (sprot)

description: A developmental pluripotency-associated 5 protein that is encoded in the genome of human.


name: general transcription initiation factor activity

description: A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.


homogentisate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of homogentisate.


name: DC4L1_HUMAN DDB1- and CUL4-associated factor 4-like protein 1 (sprot)

description: A DDB1- and CUL4-associated factor 4-like protein 1 that is encoded in the genome of human.


SREBP-SCAP complex

description: A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed.


neuromedin U receptor binding

description: Binding to one or more specific sites on a neuromedin U receptor.


Noc2p-Noc3p complex

description: A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis.


nucleus-vacuole junction

description: An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p.


description: Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide.


squalene synthase activity

description: Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate.


name: spindle attachment to meiosis I kinetochore

description: The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs.


SPDE3_HUMAN Speedy protein E3 (sprot)

A speedy protein E3 that is encoded in the genome of human.


name: negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly.


name: cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity

description: Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose = cyanidin 3-O-beta-D-sambubioside + UDP.


name: oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group.


name: ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor

description: Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin.


UDP reductase activity

description: Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin.


ADP reductase activity

description: Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin.


CDP reductase activity

description: Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin.


description: Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.


name: DNA-(apurinic or apyrimidinic site) endonuclease, initiator methionine removed form (human)

description: A DNA-(apurinic or apyrimidinic site) endonuclease (human) that has had the initiator methionine removed. UniProtKB:P27695, 2-318.


name: eukaryotic translation initiation factor 4E phosphorylated 1 (human)

description: A eukaryotic translation initiation factor 4E (human) that has been phosphorylated on the residue at the position equivalent to Ser-53 of the amino acid sequence represented by UniProtKB:P06730-1. Example: UniProtKB:P06730-1, Ser-53, MOD:00046.


An Axin that is a translation product of the human AXIN1 gene or a 1:1 ortholog thereof.


Axin-1 isoform 1 (human)

An Axin-1 isoform 1 that is encoded in the genome of human.


Axin-1 ubiquitinated 1 (human)

An Axin-1 (human) that has been ubiquitinated on the residue at the position equivalent to Lys-501 of the amino acid sequence represented by UniProtKB:O15169. UniProtKB:O15169, Lys-501, MOD:01148.


Axin-1 sequence variant L396M (human)

An Axin-1 (human) that has a Met residue at the position equivalent to Leu-396 of the amino acid sequence represented by UniProtKB:O15169-1. Example: UniProtKB:O15169-1, Leu-396, CHEBI:16044.


Axin-1 ADP-ribosylated form (human)

An Axin-1 (human) that includes at least one ADP-ribosylated residue. UniProtKB:O15169, MOD:00752.


Axin-1 isoform 2 (human)

An Axin-1 isoform 2 that is encoded in the genome of human.


Axin-1 phosphorylated 1 (human)

An Axin-1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-481, and phosphoserine at positions 486 and 493 of the amino acid sequence represented by UniProtKB:O15169. UniProtKB:O15169, Thr-481, MOD:00047|Ser-486/Ser-493, MOD:00046.


Axin-1 sequence variant Y346* (human)

An Axin-1 (human) that has has been truncated after the position equivalent to Pro-345 of the amino acid sequence represented by UniProtKB:O15169-1. Example: UniProtKB:O15169-1, 1-345.


name: Axin-1 ADP-ribosylated and ubiquitinated form (human)

description: An Axin-1 (human) that includes at least one ADP-ribosylated residue and at least one ubiquitinated lysine. UniProtKB:O15169, MOD:00752|MOD:01148.


Axin-1 sequence variant R354L (human)

An Axin-1 (human) that has a Leu residue at the position equivalent to Arg-354 of the amino acid sequence represented by UniProtKB:O15169-1. Example: UniProtKB:O15169-1, Arg-354, CHEBI:30006.


Axin-1 sequence variant W247* (human)

An Axin-1 (human) that has has been truncated after the position equivalent to Glu-246 of the amino acid sequence represented by UniProtKB:O15169-1. Example: UniProtKB:O15169-1, 1-246.


Axin-1 sequence variant E255S (human)

An Axin-1 (human) that has a Ser residue at the position equivalent to Glu-255 of the amino acid sequence represented by UniProtKB:O15169-1. Example: UniProtKB:O15169-1, Glu-255, CHEBI:29999.


Axin-1 sequence variant E406* (human)

An Axin-1 (human) that has has been truncated after the position equivalent to Ala-405 of the amino acid sequence represented by UniProtKB:O15169-1. Example: UniProtKB:O15169-1, 1-405.


name: circadian locomoter output cycles protein kaput cysteinylated 1 (human)

description: A circadian locomoter output cycles protein kaput (human) that has been cysteinylated on the residue at the position equivalent to Cys-337 of the amino acid sequence represented by UniProtKB:O15516. UniProtKB:O15516, Cys-337, MOD:00765.


name: zinc-alpha-2-glycoprotein N-glycosylated 33 (human)

description: A zinc-alpha-2-glycoprotein (human) that has been N-glycosylated at the residue equivalent to Asn-128 of the amino acid sequence represented by UniProtKB:P25311-1, in which the glycan composition is represented by GlyTouCan:G60923RB. Example: UniProtKB:P25311-1, Asn-128, MOD:00160~GNO:G60923RB.


encapsulin nanocompartment

description: Intracellular non-membrane bound organelle, consisting of proteinaceous polyhedral shells that encapsulate enzymes, protecting the contents from their surrounding milieu and/or the milieu from reactants in their interior. The self-assembling, 25-42 nm nanocompartment shell, unlike larger bacterial microcompartments, is made of only one protein, and has only a few proteins inside. Shells about vary from about 25-42 nm in diameter. The shell protein has an HK97-like fold and probably evolved from a viral protein. Artificial encapsulin nanocompartments can be expressed and filled with cargo proteins for biotechnological uses. They are found in many bacterial and a few archaeal phyla.


name: SCY1-like protein 2 methylated 1 (human)

description: A SCY1-like protein 2 (human) that has been methylated on the residue at the position equivalent to Cys-375 of the amino acid sequence represented by UniProtKB:Q6P3W7. UniProtKB:Q6P3W7, Cys-375, MOD:00660.


name: serine/threonine-protein kinase VRK2 isoform h4 (human)

description: A serine/threonine-protein kinase VRK2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86Y07-4.


prolargin O-glycosylated 6 (human)

A prolargin (human) that has been O-glycosylated at the residue equivalent to Thr-56 of the amino acid sequence represented by UniProtKB:P51888-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P51888-1, Thr-56, MOD:00005~GNO:G53434XO.


name: potassium voltage-gated channel subfamily H member 5 isoform 3 (human)

description: A voltage-gated potassium channel KCNH5 isoform 3 that is encoded in the genome of human.


description: Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H+ = 4-guanidinobutanal + CO2.


mucin-1 O-glycosylated 9 (human)

A mucin-1 (human) that has been O-glycosylated at the residue equivalent to Thr-919 of the amino acid sequence represented by UniProtKB:P15941-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P15941-1, Thr-919, MOD:00005~GNO:G58001LT.


name: ETS domain-containing transcription factor ERF isoform h2 (human)

description: An ETS domain-containing transcription factor ERF (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P50548-2.


name: heat shock protein 105 kDa deaminated 2 (human)

description: A heat shock protein 105 kDa (human) that has been deaminated on the residue at the position equivalent to Asn-96 of the amino acid sequence represented by UniProtKB:Q92598-1. Example: UniProtKB:Q92598-1, Asn-96, MOD:00684.


HSPH protein

An Hsp70 family chaperone that has its ATP-binding and substrate-binding domains separated by a linker domain of over 100 amino acids. Proteins in this class function generally as nucleotide exchange factors for cytosolic Hsp70s.


name: heat shock protein 105 kDa isoform Beta (human)

description: A heat shock protein 105 kDa isoform 2 that is encoded in the genome of human.


name: heat shock 70 kDa protein 4 methylated 1 (human)

description: A heat shock 70 kDa protein 4 (human) that has been methylated on the residue at the position equivalent to Cys-270 of the amino acid sequence represented by UniProtKB:P34932-1. Example: UniProtKB:P34932-1, Cys-270, MOD:00660.


name: heat shock protein 105 kDa methylated 1 (human)

description: A heat shock protein 105 kDa (human) that has been methylated on the residue at the position equivalent to Cys-167 of the amino acid sequence represented by UniProtKB:Q92598-1. Example: UniProtKB:Q92598-1, Cys-167, MOD:00660.


name: heat shock protein 105 kDa methylated 3 (human)

description: A heat shock protein 105 kDa (human) that has been methylated on the residue at the position equivalent to Cys-658 of the amino acid sequence represented by UniProtKB:Q92598-1. Example: UniProtKB:Q92598-1, Cys-658, MOD:00660.


heat shock 70 kDa protein 4L

An HSPH protein that is a translation product of the human HSPA4L gene or a 1:1 ortholog thereof.


name: heat shock 70 kDa protein 4 isoform 1 (human)

description: A heat shock 70 kDa protein 4 isoform 1 that is encoded in the genome of human.


name: heat shock 70 kDa protein 4 isoform h2 (human)

description: A heat shock 70 kDa protein 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34932-2.


name: heat shock protein 105 kDa cysteinylated 1 (human)

description: A heat shock protein 105 kDa (human) that has been cysteinylated on the residue at the position equivalent to Cys-213 of the amino acid sequence represented by UniProtKB:Q92598-1. Example: UniProtKB:Q92598-1, Cys-213, MOD:00765.


name: heat shock 70 kDa protein 4 cysteinylated 1 (human)

description: A heat shock 70 kDa protein 4 (human) that has been cysteinylated on the residue at the position equivalent to Cys-270 of the amino acid sequence represented by UniProtKB:P34932-1. Example: UniProtKB:P34932-1, Cys-270, MOD:00765.


name: heat shock 70 kDa protein 4L methylated 2 (human)

description: A heat shock 70 kDa protein 4L (human) that has been methylated on the residue at the position equivalent to Cys-376 of the amino acid sequence represented by UniProtKB:O95757. UniProtKB:O95757, Cys-376, MOD:00660.


name: heat shock protein 105 kDa isoform Alpha (human)

description: A heat shock protein 105 kDa isoform 1 that is encoded in the genome of human.


name: heat shock protein 105 kDa deaminated 1 (human)

description: A heat shock protein 105 kDa (human) that has been deaminated on the residue at the position equivalent to Gln-116 of the amino acid sequence represented by UniProtKB:Q92598-1. Example: UniProtKB:Q92598-1, Gln-116, MOD:00685.


name: heat shock protein 105 kDa isoform h4 (human)

description: A heat shock protein 105 kDa (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92598-4.


name: heat shock 70 kDa protein 4L methylated 1 (human)

description: A heat shock 70 kDa protein 4L (human) that has been methylated on the residue at the position equivalent to Cys-270 of the amino acid sequence represented by UniProtKB:O95757. UniProtKB:O95757, Cys-270, MOD:00660.


name: heat shock 70 kDa protein 4 methylated 2 (human)

description: A heat shock 70 kDa protein 4 (human) that has been methylated on the residue at the position equivalent to Cys-779 of the amino acid sequence represented by UniProtKB:P34932-1. Example: UniProtKB:P34932-1, Cys-779, MOD:00660.


name: heat shock protein 105 kDa deaminated 3 (human)

description: A heat shock protein 105 kDa (human) that has been deaminated on the residue at the position equivalent to Asn-61 of the amino acid sequence represented by UniProtKB:Q92598-1. Example: UniProtKB:Q92598-1, Asn-61, MOD:00684.


name: heat shock protein 105 kDa isoform h3 (human)

description: A heat shock protein 105 kDa (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92598-3.


name: heat shock 70 kDa protein 4 cysteinylated 2 (human)

description: A heat shock 70 kDa protein 4 (human) that has been cysteinylated on the residue at the position equivalent to Cys-213 of the amino acid sequence represented by UniProtKB:P34932-1. Example: UniProtKB:P34932-1, Cys-213, MOD:00765.


heat shock protein 105 kDa

An HSPH protein that is a translation product of the human HSPH1 gene or a 1:1 ortholog thereof.


name: heat shock protein 105 kDa methylated 2 (human)

description: A heat shock protein 105 kDa (human) that has been methylated on the residue at the position equivalent to Cys-213 of the amino acid sequence represented by UniProtKB:Q92598-1. Example: UniProtKB:Q92598-1, Cys-213, MOD:00660.


heat shock 70 kDa protein 4

An HSPH protein that is a translation product of the human HSPA4 gene or a 1:1 ortholog thereof.


name: heat shock 70 kDa protein 4L cysteinylated 1 (human)

description: A heat shock 70 kDa protein 4L (human) that has been cysteinylated on the residue at the position equivalent to Cys-270 of the amino acid sequence represented by UniProtKB:O95757. UniProtKB:O95757, Cys-270, MOD:00765.


14-3-3 protein gamma isoform 1 (human)

A 14-3-3 protein gamma isoform 1 that is encoded in the genome of human.


name: Ral guanine nucleotide dissociation stimulator-like 3 isoform h1 (human)

description: A Ral guanine nucleotide dissociation stimulator-like 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3MIN7-1.


tRNA transmembrane transporter activity

description: Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other.


name: collagen alpha-1(XVI) chain, signal peptide removed 3-hydroxy-proline, 4-hydroxy-proline, and galactosylhydroxylysine form (human)

description: A collagen alpha-1(XVI) chain (human) that has had the signal peptide removed and that includes at least 1 3-hydroxy-proline, at least 1 galactosylhydroxylated lysine, and at least 3 4-hydroxy-prolines. Example: UniProtKB:Q07092-1, 22-1604, MOD:00038|MOD:00039(3+)|MOD:01914.


adiponectin O-glycosylated 1 (human)

An adiponectin (human) that has been O-glycosylated at the residue equivalent to Thr-21 of the amino acid sequence represented by UniProtKB:Q15848-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:Q15848-1, Thr-21, MOD:00005~GNO:G53434XO.


name: DnaJ homolog subfamily C member 12 isoform a (human)

description: A DnaJ homolog subfamily C member 12 isoform 1 that is encoded in the genome of human.


name: protein N-terminal glutamine amidohydrolase cysteinylated 1 (human)

description: A protein N-terminal glutamine amidohydrolase (human) that has been cysteinylated on the residue at the position equivalent to Cys-50 of the amino acid sequence represented by UniProtKB:Q96HA8-1. Example: UniProtKB:Q96HA8-1, Cys-50, MOD:00765.


name: high mobility group protein 20A phosphorylated 1 (human)

description: A high mobility group protein 20A (human) that has been phosphorylated on the residue at the position equivalent to Ser-105 of the amino acid sequence represented by UniProtKB:Q9NP66-1. Example: UniProtKB:Q9NP66-1, Ser-105, MOD:00046.


name: alpha-N-acetylgalactosaminidase N-glycosylated 30 (human)

description: An alpha-N-acetylgalactosaminidase (human) that has been N-glycosylated at the residue equivalent to Asn-177 of the amino acid sequence represented by UniProtKB:P17050-1, in which the glycan structure is represented by GlyTouCan:G45359RY. Example: UniProtKB:P17050-1, Asn-177, MOD:00160~GNO:G45359RY.


name: UDP-glucuronosyltransferase 2B15 N-glycosylated 1 (human)

description: A UDP-glucuronosyltransferase 2B15 (human) that has been N-glycosylated at the residue equivalent to Asn-316 of the amino acid sequence represented by UniProtKB:P54855-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P54855-1, Asn-316, MOD:00160~GNO:G06247RL.


name: BCAS3 microtubule associated cell migration factor isoform h4 (human)

description: A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-8.


name: BCAS3 microtubule associated cell migration factor isoform h1 (human)

description: A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-2.


name: BCAS3 microtubule associated cell migration factor phosphorylated 1 (human)

description: A BCAS3 microtubule associated cell migration factor (human) that has been phosphorylated on the residue at the position equivalent to Ser-180 of the amino acid sequence represented by UniProtKB:Q9H6U6-1. Example: UniProtKB:Q9H6U6-1, Ser-180, MOD:00046.


name: BCAS3 microtubule associated cell migration factor isoform 2 (human)

description: A BCAS3 microtubule associated cell migration factor isoform 1 that is encoded in the genome of human.


name: BCAS3 microtubule associated cell migration factor isoform h5 (human)

description: A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-7.


name: BCAS3 microtubule associated cell migration factor isoform h3 (human)

description: A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-3.


name: BCAS3 microtubule associated cell migration factor isoform h6 (human)

description: A BCAS3 microtubule associated cell migration factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6U6-6.


name: biogenesis of lysosome-related organelles complex 1 subunit 2 deaminated 1 (human)

description: A biogenesis of lysosome-related organelles complex 1 subunit 2 (human) that has been deaminated on the residue at the position equivalent to Gln-120 of the amino acid sequence represented by UniProtKB:Q6QNY1-1. Example: UniProtKB:Q6QNY1-1, Gln-120, MOD:00685.


name: heat shock factor 2-binding protein isoform h2 (human)

description: A heat shock factor 2-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75031-2.


name: heat shock factor 2-binding protein isoform h1 (human)

description: A heat shock factor 2-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75031-1.


name: T-cell surface glycoprotein CD4 N-glycosylated 23 (human)

description: A T-cell surface glycoprotein CD4 (human) that has been N-glycosylated at the residue equivalent to Asn-296 of the amino acid sequence represented by UniProtKB:P01730-1, in which the glycan structure is represented by GlyTouCan:G65890UA. Example: UniProtKB:P01730-1, Asn-296, MOD:00160~GNO:G65890UA.


name: Ras-related GTP-binding protein A deaminated 1 (human)

description: A Ras-related GTP-binding protein A (human) that has been deaminated on the residue at the position equivalent to Asn-30 of the amino acid sequence represented by UniProtKB:Q7L523. UniProtKB:Q7L523, Asn-30, MOD:00684.


indole catabolic process

description: The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).


indole biosynthetic process

description: The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).


name: peptide chain release factor 1-like, mitochondrial isoform h3 (human)

description: A peptide chain release factor 1-like, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UGC7-3.


name: specification of animal organ axis polarity

description: The process in which the polarity of an animal organ axis is specified.


name: ATP-binding cassette sub-family A member 9 isoform h3 (human)

description: An ATP-binding cassette sub-family A member 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IUA7-3.


neogenin isoform h2 (human)

A neogenin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92859-2.


name: excitatory amino acid transporter 4 isoform h1 (human)

description: An excitatory amino acid transporter 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48664-1.


name: mating-type a-factor pheromone receptor activity

description: Combining with the mating-type a-factor pheromone to initiate a change in cell activity.


name: nuclear envelope integral membrane protein 2 isoform h1 (human)

description: A nuclear envelope integral membrane protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A6NFY4-1.


name: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A deaminated 1 (human)

description: A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (human) that has been deaminated on the residue at the position equivalent to Asn-545 of the amino acid sequence represented by UniProtKB:P46977-1. Example: UniProtKB:P46977-1, Asn-545, MOD:00684.


name: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h2 (human)

description: A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-2.


name: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3 (human)

description: A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3 that is encoded in the genome of human.


name: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h1 (human)

description: A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-1.


name: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h4 (human)

description: A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-4.


name: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase phosphorylated form (human)

description: A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that includes at least one phosphorylated residue. UniProtKB:Q99640, MOD:00696.


name: lymphoid-specific helicase isoform h3 (human)

description: A lymphoid-specific helicase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRZ9-3.


A cyclin-A that is a translation product of the human CCNA1 gene or a 1:1 ortholog thereof.


cyclin-A1 ubiquitinated form (human)

A cyclin-A1 (human) that includes at least one ubiquitinated lysine. UniProtKB:P78396, MOD:01148.


cyclin-A1 isoform h1 (human)

A cyclin-A1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P78396-1.


cyclin-A1 isoform h2 (human)

A cyclin-A1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P78396-2.


cyclin-A1 isoform 3 (human)

A cyclin-A1 isoform 3 that is encoded in the genome of human.


cyclin-A1 cysteinylated 1 (human)

A cyclin-A1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-422 of the amino acid sequence represented by UniProtKB:P78396-1. Example: UniProtKB:P78396-1, Cys-422, MOD:00765.


name: dynein regulatory complex subunit 2 isoform h2 (human)

description: A dynein regulatory complex subunit 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IXS2-2.