name: TOPB1_HUMAN DNA topoisomerase 2-binding protein 1 (sprot)

description: A DNA topoisomerase 2-binding protein 1 that is encoded in the genome of human.


name: IP6K1_HUMAN Inositol hexakisphosphate kinase 1 (sprot)

description: An inositol hexakisphosphate kinase 1 that is encoded in the genome of human.


name: inositol 5-diphosphate pentakisphosphate 5-kinase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate.


name: inositol diphosphate tetrakisphosphate kinase activity

description: Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate.


name: RT27_HUMAN Small ribosomal subunit protein mS27 (sprot)

description: A small ribosomal subunit protein mS27 that is encoded in the genome of human.


name: ELMO1_HUMAN Engulfment and cell motility protein 1 (sprot)

description: An engulfment and cell motility protein 1 that is encoded in the genome of human.


name: WASF1_HUMAN Actin-binding protein WASF1 (sprot)

description: An actin-binding protein WASF1 that is encoded in the genome of human.


name: BAP1_HUMAN Ubiquitin carboxyl-terminal hydrolase BAP1 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase BAP1 that is encoded in the genome of human.


thrombocyte differentiation

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.


nucleate erythrocyte differentiation

description: The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds.


name: PHYIP_HUMAN Phytanoyl-CoA hydroxylase-interacting protein (sprot)

description: A phytanoyl-CoA hydroxylase-interacting protein that is encoded in the genome of human.


name: FIG4_HUMAN Polyphosphoinositide phosphatase (sprot)

description: A polyphosphoinositide phosphatase that is encoded in the genome of human.


TICN2_HUMAN Testican-2 (sprot)

A testican-2 that is encoded in the genome of human.


DCNL4_HUMAN DCN1-like protein 4 (sprot)

A DCN1-like protein 4 that is encoded in the genome of human.


name: RPGF5_HUMAN Rap guanine nucleotide exchange factor 5 (sprot)

description: A Rap guanine nucleotide exchange factor 5 that is encoded in the genome of human.


F168A_HUMAN Protein FAM168A (sprot)

A protein FAM168A that is encoded in the genome of human.


name: P55G_HUMAN Phosphatidylinositol 3-kinase regulatory subunit gamma (sprot)

description: A phosphatidylinositol 3-kinase regulatory subunit gamma that is encoded in the genome of human.


name: NR4A3_HUMAN Nuclear receptor subfamily 4 group A member 3 (sprot)

description: A nuclear receptor subfamily 4 group A member 3 that is encoded in the genome of human.


name: positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An Fc-epsilon receptor signaling pathway that results in the change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors.


name: AP3S1_HUMAN AP-3 complex subunit sigma-1 (sprot)

description: An AP-3 complex subunit sigma-1 that is encoded in the genome of human.


TSC1_HUMAN Hamartin (sprot)

A hamartin that is encoded in the genome of human.


memory T cell differentiation

description: The process in which a newly activated T cell acquires specialized features of a memory T cell.


name: UBXN4_HUMAN UBX domain-containing protein 4 (sprot)

description: A UBX domain-containing protein 4 that is encoded in the genome of human.


PHF3_HUMAN PHD finger protein 3 (sprot)

A PHD finger protein 3 that is encoded in the genome of human.


name: SL9A6_HUMAN Sodium/hydrogen exchanger 6 (sprot)

description: A sodium/hydrogen exchanger 6 that is encoded in the genome of human.


name: CCL17_HUMAN C-C motif chemokine 17 (sprot)

description: A C-C motif chemokine 17 that is encoded in the genome of human.


name: MAML1_HUMAN Mastermind-like protein 1 (sprot)

description: A mastermind-like protein 1 that is encoded in the genome of human.


NDRG1_HUMAN Protein NDRG1 (sprot)

A protein NDRG1 that is encoded in the genome of human.


name: HS105_HUMAN Heat shock protein 105 kDa (sprot)

description: A heat shock protein 105 kDa that is encoded in the genome of human.


SEPT8_HUMAN Septin-8 (sprot)

A septin-8 that is encoded in the genome of human.


name: CNOT9_HUMAN CCR4-NOT transcription complex subunit 9 (sprot)

description: A CCR4-NOT transcription complex subunit 9 that is encoded in the genome of human.


name: LGAT1_HUMAN Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (sprot)

description: An acyl-CoA:lysophosphatidylglycerol acyltransferase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.


description: Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine.


name: DOCK2_HUMAN Dedicator of cytokinesis protein 2 (sprot)

description: A dedicator of cytokinesis protein 2 that is encoded in the genome of human.


name: TBCD5_HUMAN TBC1 domain family member 5 (sprot)

description: A TBC1 domain family member 5 that is encoded in the genome of human.


name: ZN592_HUMAN Zinc finger protein 592 (sprot)

description: A zinc finger protein 592 that is encoded in the genome of human.


name: EDEM1_HUMAN ER degradation-enhancing alpha-mannosidase-like protein 1 (sprot)

description: An ER degradation-enhancing alpha-mannosidase-like protein 1 that is encoded in the genome of human.


mannoprotein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a mannoprotein, a protein that contains covalently bound mannose residues.


JADE3_HUMAN Protein Jade-3 (sprot)

A protein Jade-3 that is encoded in the genome of human.


name: MY18A_HUMAN Unconventional myosin-XVIIIa (sprot)

description: A myosin-XVIIIa that is encoded in the genome of human.


asymmetric Golgi ribbon formation

description: The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that contributes to the establishment of epithelial cell polarity.


name: LAR4B_HUMAN La-related protein 4B (sprot)

description: A La-related protein 4B that is encoded in the genome of human.


name: GCN1_HUMAN Stalled ribosome sensor GCN1 (sprot)

description: A stalled ribosome sensor GCN1 that is encoded in the genome of human.


GCN2-mediated signaling

description: A series of reactions in which a signal is passed on to downstream proteins within the cell via GCN2 (also known as EIF2AK4), an intracellular protein kinase that is activated by stress signals, such as amino acid starvation.


name: protein-RNA covalent cross-linking repair

description: A process that rescues stalled ribosomes by removing the covalent cross-link between RNA and a protein.


name: NPIB3_HUMAN Nuclear pore complex-interacting protein family member B3 (sprot)

description: A nuclear pore complex-interacting protein family member B3 that is encoded in the genome of human.


name: ZN516_HUMAN Zinc finger protein 516 (sprot)

description: A zinc finger protein 516 that is encoded in the genome of human.


name: HMHA1_HUMAN Rho GTPase-activating protein 45 (sprot)

description: A Rho GTPase-activating protein 45 that is encoded in the genome of human.


name: PRP16_HUMAN Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (sprot)

description: A pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 that is encoded in the genome of human.


name: NU205_HUMAN Nuclear pore complex protein Nup205 (sprot)

description: A nuclear pore complex protein Nup205 that is encoded in the genome of human.


name: RUBIC_HUMAN Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (sprot)

description: A Run domain Beclin-1-interacting and cysteine-rich domain-containing protein that is encoded in the genome of human.


name: TTC9A_HUMAN Tetratricopeptide repeat protein 9A (sprot)

description: A tetratricopeptide repeat protein 9A that is encoded in the genome of human.


name: APBP2_HUMAN Amyloid protein-binding protein 2 (sprot)

description: An amyloid protein-binding protein 2 that is encoded in the genome of human.


name: ANS1A_HUMAN Ankyrin repeat and SAM domain-containing protein 1A (sprot)

description: An ankyrin repeat and SAM domain-containing protein 1A that is encoded in the genome of human.


PXDN_HUMAN Peroxidasin homolog (sprot)

A peroxidasin that is encoded in the genome of human.


name: K0232_HUMAN Uncharacterized protein KIAA0232 (sprot)

description: An uncharacterized protein KIAA0232 that is encoded in the genome of human.


SGCD_HUMAN Delta-sarcoglycan (sprot)

A delta-sarcoglycan that is encoded in the genome of human.


coronary vasculature morphogenesis

description: The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood.


name: DYRK2_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 2 (sprot)

description: A dual specificity tyrosine-phosphorylation-regulated kinase 2 that is encoded in the genome of human.


name: LPAR1_HUMAN Lysophosphatidic acid receptor 1 (sprot)

description: A lysophosphatidic acid receptor 1 that is encoded in the genome of human.


lysophosphatidic acid receptor activity

description: Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein.


name: cellular response to 1-oleoyl-sn-glycerol 3-phosphate

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus.


FAN_HUMAN Protein FAN (sprot)

A protein FAN that is encoded in the genome of human.


name: FCGRB_HUMAN Putative high affinity immunoglobulin gamma Fc receptor IB (sprot)

description: A putative high affinity immunoglobulin gamma Fc receptor IB that is encoded in the genome of human.


name: GPI8_HUMAN GPI-anchor transamidase (sprot)

description: A GPI-anchor transamidase that is encoded in the genome of human.


name: TF3A_HUMAN Transcription factor IIIA (sprot)

description: A transcription factor IIIA that is encoded in the genome of human.


name: RT31_HUMAN Small ribosomal subunit protein mS31 (sprot)

description: A small ribosomal subunit protein mS31 that is encoded in the genome of human.


name: AKAP1_HUMAN A-kinase anchor protein 1, mitochondrial (sprot)

description: An A-kinase anchor protein 1, mitochondrial that is encoded in the genome of human.


name: ZN75C_HUMAN Putative zinc finger protein 75C (sprot)


name: SORL_HUMAN Sortilin-related receptor (sprot)

description: A sortilin-related receptor that is encoded in the genome of human.


protein retention in Golgi apparatus

description: The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known.


name: positive regulation of early endosome to recycling endosome transport

description: Any process that activates or increases the frequency, rate or extent of early endosome to recycling endosome transport.


name: negative regulation of neurofibrillary tangle assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of neurofibrillary tangle assembly.


name: CENPI_HUMAN Centromere protein I (sprot)

description: A centromere protein I that is encoded in the genome of human.


name: RSCA1_HUMAN Regulatory solute carrier protein family 1 member 1 (sprot)

description: A regulatory solute carrier protein family 1 member 1 that is encoded in the genome of human.


name: negative regulation of nucleoside transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: ALG3_HUMAN Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (sprot)

description: A dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase that is encoded in the genome of human.


alpha-1,3-mannosyltransferase activity

description: Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage.


description: Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.


NEUG_HUMAN Neurogranin (sprot)

A neurogranin that is encoded in the genome of human.


name: AN32B_HUMAN Acidic leucine-rich nuclear phosphoprotein 32 family member B (sprot)

description: An acidic leucine-rich nuclear phosphoprotein 32 family member B that is encoded in the genome of human.


NECT2_HUMAN Nectin-2 (sprot)

A nectin-2 that is encoded in the genome of human.


name: coreceptor-mediated virion attachment to host cell

description: The process by which a virion attaches to a host cell by binding to a co-receptor on the host cell surface.


name: establishment of mitochondrion localization

description: The directed movement of the mitochondrion to a specific location.


name: PGTA_HUMAN Geranylgeranyl transferase type-2 subunit alpha (sprot)

description: A geranylgeranyl transferase type-2 subunit alpha that is encoded in the genome of human.


name: RAD54_HUMAN DNA repair and recombination protein RAD54-like (sprot)

description: A DNA repair and recombination protein RAD54-like that is encoded in the genome of human.


name: PTPRU_HUMAN Receptor-type tyrosine-protein phosphatase U (sprot)

description: A receptor-type tyrosine-protein phosphatase U that is encoded in the genome of human.


name: RND1_HUMAN Rho-related GTP-binding protein Rho6 (sprot)

description: A Rho-related GTP-binding protein Rho6 that is encoded in the genome of human.


name: ESR2_HUMAN Estrogen receptor beta (sprot)

description: An estrogen receptor beta that is encoded in the genome of human.


name: PRCC_HUMAN Proline-rich protein PRCC (sprot)

description: A proline-rich protein PRCC that is encoded in the genome of human.


TFG_HUMAN Protein TFG (sprot)

A protein TFG that is encoded in the genome of human.


RYR2_HUMAN Ryanodine receptor 2 (sprot)

A ryanodine receptor 2 that is encoded in the genome of human.


name: establishment of protein localization to endoplasmic reticulum

description: The directed movement of a protein to a specific location in the endoplasmic reticulum.


name: RSLAA_HUMAN Ras-like protein family member 10A (sprot)

description: A Ras-like protein family member 10A that is encoded in the genome of human.


name: US6NL_HUMAN USP6 N-terminal-like protein (sprot)

description: A USP6 N-terminal-like protein that is encoded in the genome of human.


name: HTRA1_HUMAN Serine protease HTRA1 (sprot)

description: A serine protease HTRA1 that is encoded in the genome of human.


name: ARC1A_HUMAN Actin-related protein 2/3 complex subunit 1A (sprot)

description: An actin-related protein 2/3 complex subunit 1A that is encoded in the genome of human.


name: THRSP_HUMAN Thyroid hormone-inducible hepatic protein (sprot)

description: A thyroid hormone-inducible hepatic protein that is encoded in the genome of human.


name: TAF4B_HUMAN Transcription initiation factor TFIID subunit 4B (sprot)

description: A transcription initiation factor TFIID subunit 4B that is encoded in the genome of human.


TENR_HUMAN Tenascin-R (sprot)

A tenascin-R that is encoded in the genome of human.


name: RORB_HUMAN Nuclear receptor ROR-beta (sprot)

description: A nuclear receptor ROR-beta that is encoded in the genome of human.


name: AP2C_HUMAN Transcription factor AP-2 gamma (sprot)

description: A transcription factor AP-2 gamma that is encoded in the genome of human.


name: TF2H4_HUMAN General transcription factor IIH subunit 4 (sprot)

description: A general transcription factor IIH subunit 4 that is encoded in the genome of human.


name: KRT35_HUMAN Keratin, type I cuticular Ha5 (sprot)

description: A keratin, type I cuticular Ha5 that is encoded in the genome of human.


name: SFRP3_HUMAN Secreted frizzled-related protein 3 (sprot)

description: A secreted frizzled-related protein 3 that is encoded in the genome of human.


negative regulation of cell development

description: Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.


name: negative regulation of hepatocyte differentiation

description: Any process that stops or decreases the rate or extent of hepatocyte differentiation.


name: RREB1_HUMAN Ras-responsive element-binding protein 1 (sprot)

description: A Ras-responsive element-binding protein 1 that is encoded in the genome of human.


name: HDAC2_HUMAN Histone deacetylase 2 (sprot)

description: A histone deacetylase 2 that is encoded in the genome of human.


name: positive regulation of male mating behavior

description: Any process that activates or increases the frequency, rate or extent of male mating behavior.


name: negative regulation of peptidyl-lysine acetylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation.


name: DDX12_HUMAN Putative ATP-dependent RNA helicase DDX12 (sprot)


name: CDKL2_HUMAN Cyclin-dependent kinase-like 2 (sprot)

description: A cyclin-dependent kinase-like 2 that is encoded in the genome of human.


SYN2_HUMAN Synapsin-2 (sprot)

A synapsin-2 that is encoded in the genome of human.


name: RDH5_HUMAN Retinol dehydrogenase 5 (sprot)

description: A retinol dehydrogenase 5 that is encoded in the genome of human.


name: DPF1_HUMAN Zinc finger protein neuro-d4 (sprot)

description: A zinc finger protein neuro-d4 that is encoded in the genome of human.


name: STAM1_HUMAN Signal transducing adapter molecule 1 (sprot)

description: A signal transducing adapter molecule 1 that is encoded in the genome of human.


name: DPF3_HUMAN Zinc finger protein DPF3 (sprot)

description: A zinc finger protein DPF3 that is encoded in the genome of human.


name: REQU_HUMAN Zinc finger protein ubi-d4 (sprot)

description: A zinc finger protein ubi-d4 that is encoded in the genome of human.


name: negative regulation of myeloid progenitor cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation.


name: PROX1_HUMAN Prospero homeobox protein 1 (sprot)

description: A prospero homeobox protein 1 that is encoded in the genome of human.


hepatocyte cell migration

description: The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes.


otic placode formation

description: The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain.


name: branching involved in pancreas morphogenesis

description: The process in which the branches of the pancreas are generated and organized.


name: positive regulation of cell cycle checkpoint

description: Any process that activates or increases the frequency, rate or extent of cell cycle checkpoint.


name: positive regulation of forebrain neuron differentiation

description: Any process that activates or increases the frequency, rate or extent of forebrain neuron differentiation.


name: SC65_HUMAN Endoplasmic reticulum protein SC65 (sprot)

description: An endoplasmic reticulum protein SC65 that is encoded in the genome of human.


CBP_HUMAN CREB-binding protein (sprot)

A CREB-binding protein that is encoded in the genome of human.


name: peptide lactyltransferase (CoA-dependent) activity

description: Catalysis of the reaction: (L-lysyl-[protein] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[protein].


name: KAT6A_HUMAN Histone acetyltransferase KAT6A (sprot)

description: A histone acetyltransferase KAT6A that is encoded in the genome of human.


name: DLG3_HUMAN Disks large homolog 3 (sprot)

description: A disks large homolog 3 that is encoded in the genome of human.


SYMPK_HUMAN Symplekin (sprot)

A symplekin that is encoded in the genome of human.


name: EZH1_HUMAN Histone-lysine N-methyltransferase EZH1 (sprot)

description: A histone-lysine N-methyltransferase EZH1 that is encoded in the genome of human.


name: N42L2_HUMAN NEDD4-binding protein 2-like 2 (sprot)

description: A NEDD4-binding protein 2-like 2 that is encoded in the genome of human.


name: RBP56_HUMAN TATA-binding protein-associated factor 2N (sprot)

description: A TATA-binding protein-associated factor 2N that is encoded in the genome of human.


name: GOGA1_HUMAN Golgin subfamily A member 1 (sprot)

description: A golgin subfamily A member 1 that is encoded in the genome of human.


name: KCNJ9_HUMAN G protein-activated inward rectifier potassium channel 3 (sprot)

description: A G protein-activated inward rectifier potassium channel 3 that is encoded in the genome of human.


name: IOD2_HUMAN Type II iodothyronine deiodinase (sprot)

description: A type II iodothyronine deiodinase that is encoded in the genome of human.


EVPL_HUMAN Envoplakin (sprot)

An envoplakin that is encoded in the genome of human.


name: regulation of antibacterial peptide production

description: Any process that modulates the frequency, rate, or extent of antibacterial peptide production.


name: HYAS2_HUMAN Hyaluronan synthase 2 (sprot)

description: A hyaluronan synthase 2 that is encoded in the genome of human.


name: GGH_HUMAN Gamma-glutamyl hydrolase (sprot)

description: A gamma-glutamyl hydrolase that is encoded in the genome of human.


gamma-glutamyl-peptidase activity

description: Catalysis of the cleavage of a gamma-linked glutamate bond.


name: NRCAM_HUMAN Neuronal cell adhesion molecule (sprot)

description: A neuronal cell adhesion molecule that is encoded in the genome of human.


name: PCSK5_HUMAN Proprotein convertase subtilisin/kexin type 5 (sprot)

description: A proprotein convertase subtilisin/kexin type 5 that is encoded in the genome of human.


name: HXB13_HUMAN Homeobox protein Hox-B13 (sprot)

description: A homeobox protein Hox-B13 that is encoded in the genome of human.


COR2A_HUMAN Coronin-2A (sprot)

A coronin-2A that is encoded in the genome of human.


name: KAT2A_HUMAN Histone acetyltransferase KAT2A (sprot)

description: A histone acetyltransferase KAT2A that is encoded in the genome of human.


histone H3K9 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9).


histone succinyltransferase activity

description: Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone.


histone glutaryltransferase activity

description: Catalysis of the reaction: glutaryl-CoA + histone = CoA + H+ + N6-glutaryl-histone.


peptidyl-lysine glutarylation

description: The glutarylation of a lysine residue in a protein.


name: KAT2B_HUMAN Histone acetyltransferase KAT2B (sprot)

description: A histone acetyltransferase KAT2B that is encoded in the genome of human.


name: NELL1_HUMAN Protein kinase C-binding protein NELL1 (sprot)

description: A protein kinase C-binding protein NELL1 that is encoded in the genome of human.


JARD2_HUMAN Protein Jumonji (sprot)

A protein Jumonji that is encoded in the genome of human.


name: protein localization to pericentric heterochromatin

description: A process in which a protein is transported to, or maintained in the pericentric heterochromatin.


name: RPGR_HUMAN X-linked retinitis pigmentosa GTPase regulator (sprot)

description: An X-linked retinitis pigmentosa GTPase regulator that is encoded in the genome of human.


name: SHIP1_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (sprot)

description: A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 that is encoded in the genome of human.


name: FRAT1_HUMAN Proto-oncogene FRAT1 (sprot)

description: A proto-oncogene FRAT1 that is encoded in the genome of human.


EDA_HUMAN Ectodysplasin-A (sprot)

An ectodysplasin-A that is encoded in the genome of human.


trachea gland development

description: The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection.


name: HYAS1_HUMAN Hyaluronan synthase 1 (sprot)

description: A hyaluronan synthase 1 that is encoded in the genome of human.


name: DDX17_HUMAN Probable ATP-dependent RNA helicase DDX17 (sprot)

description: A probable ATP-dependent RNA helicase DDX17 that is encoded in the genome of human.


name: B2CL2_HUMAN Bcl-2-like protein 2 (sprot)

description: A protein that is a translation product of any of the following genes in human: BCL2L2, or a readthrough of the BCL2L2-PABPN1 genes.


name: TANK_HUMAN TRAF family member-associated NF-kappa-B activator (sprot)

description: A TRAF family member-associated NF-kappa-B activator that is encoded in the genome of human.


name: positive regulation of ubiquitin-specific protease activity

description: Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity.


name: KIFA3_HUMAN Kinesin-associated protein 3 (sprot)

description: A kinesin-associated protein 3 that is encoded in the genome of human.


name: positive regulation of calcium-dependent cell-cell adhesion

description: Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion.


name: GHSR_HUMAN Growth hormone secretagogue receptor type 1 (sprot)

description: A growth hormone secretagogue receptor that is encoded in the genome of human.


name: growth hormone secretagogue receptor activity

description: Combining with ghrelin to initiate a change in cell activity.


regulation of hindgut contraction

description: Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.


regulation of growth hormone secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell.


name: positive regulation of small intestinal transit

description: Any process that increases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine.


CASPA_HUMAN Caspase-10 (sprot)

A caspase-10 that is encoded in the genome of human.


SEM4D_HUMAN Semaphorin-4D (sprot)

A semaphorin-4D that is encoded in the genome of human.


leukocyte aggregation

description: The adhesion of one leukocyte to one or more other leukocytes via adhesion molecules.


name: positive regulation of inhibitory synapse assembly

description: Any process that activates or increases the frequency, rate or extent of inhibitory synapse assembly.


name: ATOH1_HUMAN Transcription factor ATOH1 (sprot)

description: A transcription factor ATOH1 that is encoded in the genome of human.


name: auditory receptor cell fate specification

description: The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


name: auditory receptor cell fate determination

description: The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed.


NEO1_HUMAN Neogenin (sprot)

A neogenin that is encoded in the genome of human.


name: APBB2_HUMAN Amyloid beta precursor protein binding family B member 2 (sprot)

description: An amyloid beta precursor protein binding family B member 2 that is encoded in the genome of human.


name: negative regulation of cell cycle phase transition

description: Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition.


PMM1_HUMAN Phosphomannomutase 1 (sprot)

A phosphomannomutase 1 that is encoded in the genome of human.


name: DNSL2_HUMAN Deoxyribonuclease-1-like 2 (sprot)

description: A deoxyribonuclease-1-like 2 that is encoded in the genome of human.


corneocyte development

description: The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis.


KLK6_HUMAN Kallikrein-6 (sprot)

A kallikrein-6 that is encoded in the genome of human.


name: RAD50_HUMAN DNA repair protein RAD50 (sprot)

description: A DNA repair protein RAD50 that is encoded in the genome of human.


name: CELF1_HUMAN CUGBP Elav-like family member 1 (sprot)

description: A CUGBP Elav-like family member 1 that is encoded in the genome of human.


BRE binding

description: Binding to a BRE RNA element (Bruno response element).


name: OSTF1_HUMAN Osteoclast-stimulating factor 1 (sprot)

description: An osteoclast-stimulating factor 1 that is encoded in the genome of human.


NGN1_HUMAN Neurogenin-1 (sprot)

A neurogenin-1 that is encoded in the genome of human.


name: MRP2_HUMAN ATP-binding cassette sub-family C member 2 (sprot)

description: An ATP-binding cassette sub-family C member 2 that is encoded in the genome of human.


name: bilirubin transmembrane transporter activity

description: Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile.


bilirubin transport

description: The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: ARHG1_HUMAN Rho guanine nucleotide exchange factor 1 (sprot)

description: A Rho guanine nucleotide exchange factor 1 that is encoded in the genome of human.


name: XPF_HUMAN DNA repair endonuclease XPF (sprot)

description: A DNA repair endonuclease XPF that is encoded in the genome of human.


telomerase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of telomerase.


name: nucleotide-excision repair involved in interstrand cross-link repair

description: Any nucleotide-excision repair that is involved in interstrand cross-link repair.


name: negative regulation of double-stranded telomeric DNA binding

description: Any process that stops, prevents or reduces the frequency, rate or extent of double-stranded telomeric DNA binding.


name: UFD1_HUMAN Ubiquitin recognition factor in ER-associated degradation protein 1 (sprot)

description: A ubiquitin recognition factor in ER-associated degradation protein 1 that is encoded in the genome of human.


name: GSLG1_HUMAN Golgi apparatus protein 1 (sprot)

description: A Golgi apparatus protein 1 that is encoded in the genome of human.


name: RENT1_HUMAN Regulator of nonsense transcripts 1 (sprot)

description: A regulator of nonsense transcripts 1 that is encoded in the genome of human.


name: RL3L_HUMAN Ribosomal protein uL3-like (sprot)

description: A ribosomal protein uL3-like that is encoded in the genome of human.


name: HPS1_HUMAN BLOC-3 complex member HPS1 (sprot)

description: A BLOC-3 complex member HPS1 that is encoded in the genome of human.


BLOC-3 complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins.


name: CDS1_HUMAN Phosphatidate cytidylyltransferase 1 (sprot)

description: A phosphatidate cytidylyltransferase 1 that is encoded in the genome of human.


name: DAZL_HUMAN Deleted in azoospermia-like (sprot)

description: A deleted in azoospermia-like that is encoded in the genome of human.


female meiosis II

description: The cell cycle process in which the second meiotic division occurs in the female germline.


name: CSN5_HUMAN COP9 signalosome complex subunit 5 (sprot)

description: A COP9 signalosome complex subunit 5 that is encoded in the genome of human.


name: GATA6_HUMAN Transcription factor GATA-6 (sprot)

description: A transcription factor GATA-6 that is encoded in the genome of human.


name: regulation of antimicrobial humoral response

description: Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response.


endodermal cell fate determination

description: The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.


name: negative regulation of transforming growth factor beta2 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2.


tube morphogenesis

description: The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.


name: negative regulation of sebum secreting cell proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of sebum secreting cell proliferation.


name: SC5A5_HUMAN Sodium/iodide cotransporter (sprot)

description: A sodium/iodide cotransporter that is encoded in the genome of human.


name: sodium:iodide symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in).


name: monoatomic anion:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic anion(out) + Na+(out) = monoatomic anion(in) + Na+(in).


iodide transmembrane transport

description: The process in which iodide is transported across a membrane.


name: cellular response to Thyroid stimulating hormone

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus.


name: FGF13_HUMAN Fibroblast growth factor 13 (sprot)

description: A fibroblast growth factor 13 that is encoded in the genome of human.


name: FGF11_HUMAN Fibroblast growth factor 11 (sprot)

description: A fibroblast growth factor 11 that is encoded in the genome of human.


name: FGF14_HUMAN Fibroblast growth factor 14 (sprot)

description: A fibroblast growth factor 14 that is encoded in the genome of human.


name: GPKOW_HUMAN G-patch domain and KOW motifs-containing protein (sprot)

description: A G-patch domain and KOW motifs-containing protein that is encoded in the genome of human.


name: M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (sprot)

description: A mitogen-activated protein kinase kinase kinase kinase 1 that is encoded in the genome of human.


name: SMRC1_HUMAN SWI/SNF complex subunit SMARCC1 (sprot)

description: A SWI/SNF complex subunit SMARCC1 that is encoded in the genome of human.


name: SMRD2_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (sprot)

description: A SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 that is encoded in the genome of human.


name: RAB1C_HUMAN Putative Ras-related protein Rab-1C (sprot)


name: RAB8B_HUMAN Ras-related protein Rab-8B (sprot)

description: A Ras-related protein Rab-8B that is encoded in the genome of human.


cell-substrate junction organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix.


name: PTPR2_HUMAN Receptor-type tyrosine-protein phosphatase N2 (sprot)

description: A receptor-type tyrosine-protein phosphatase N2 that is encoded in the genome of human.


name: BAD_HUMAN Bcl2-associated agonist of cell death (sprot)

description: A Bcl2-associated agonist of cell death that is encoded in the genome of human.


name: positive regulation of glucokinase activity

description: Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.


ADP metabolic process

description: The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate.


name: positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

description: Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress.


EXTL1_HUMAN Exostosin-like 1 (sprot)

An exostosin-like 1 that is encoded in the genome of human.


name: FUBP2_HUMAN Far upstream element-binding protein 2 (sprot)

description: A far upstream element-binding protein 2 that is encoded in the genome of human.


name: GCDH_HUMAN Glutaryl-CoA dehydrogenase, mitochondrial (sprot)

description: A glutaryl-CoA dehydrogenase, mitochondrial that is encoded in the genome of human.


glutaryl-CoA dehydrogenase activity

description: Catalysis of the reaction: glutaryl-CoA + 2 H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein].


name: FOXJ1_HUMAN Forkhead box protein J1 (sprot)

description: A forkhead box protein J1 that is encoded in the genome of human.


central tolerance induction

description: Tolerance induction in the central lymphoid organs: the thymus and bone marrow.


name: positive regulation of central B cell tolerance induction

description: Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction.


name: glomerular parietal epithelial cell development

description: The process whose specific outcome is the progression of a glomerular parietal epithelial cell over time, from its formation to the mature structure. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport.


name: KCNN1_HUMAN Small conductance calcium-activated potassium channel protein 1 (sprot)

description: A small conductance calcium-activated potassium channel protein 1 that is encoded in the genome of human.


name: KCNB2_HUMAN Potassium voltage-gated channel subfamily B member 2 (sprot)

description: A voltage-gated potassium channel KCNB2 that is encoded in the genome of human.


PRG4_HUMAN Proteoglycan 4 (sprot)

A proteoglycan 4 that is encoded in the genome of human.


name: TNR14_HUMAN Tumor necrosis factor receptor superfamily member 14 (sprot)

description: A tumor necrosis factor receptor superfamily member 14 that is encoded in the genome of human.


name: SO2A1_HUMAN Solute carrier organic anion transporter family member 2A1 (sprot)

description: A solute carrier organic anion transporter family member 2A1 that is encoded in the genome of human.


name: RIT1_HUMAN GTP-binding protein Rit1 (sprot)

description: A GTP-binding protein Rit1 that is encoded in the genome of human.


name: SNPC3_HUMAN snRNA-activating protein complex subunit 3 (sprot)

description: An snRNA-activating protein complex subunit 3 that is encoded in the genome of human.


name: PEX13_HUMAN Peroxisomal membrane protein PEX13 (sprot)

description: A peroxisomal membrane protein PEX13 that is encoded in the genome of human.


TNPO1_HUMAN Transportin-1 (sprot)

A transportin-1 that is encoded in the genome of human.


name: ARHG2_HUMAN Rho guanine nucleotide exchange factor 2 (sprot)

description: A Rho guanine nucleotide exchange factor 2 that is encoded in the genome of human.


name: NEP1_HUMAN Ribosomal RNA small subunit methyltransferase NEP1 (sprot)

description: A ribosomal RNA small subunit methyltransferase NEP1 that is encoded in the genome of human.


name: rRNA (pseudouridine) methyltransferase activity

description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule.


nucleologenesis

description: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells.


NINJ1_HUMAN Ninjurin-1 (sprot)

A ninjurin-1 that is encoded in the genome of human.


name: IRF7_HUMAN Interferon regulatory factor 7 (sprot)

description: An interferon regulatory factor 7 that is encoded in the genome of human.


establishment of viral latency

description: A process by which a virus establishes a latent state within its host, either as an integrated provirus within the host genome or as an episome, where viral genome remains in the cytoplasm or nucleus as distinct objects.


name: regulation of MyD88-independent toll-like receptor signaling pathway

description: Any process that modulates the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway.


regulation of monocyte differentiation

description: Any process that modulates the frequency, rate or extent of monocyte differentiation.


name: DLX4_HUMAN Homeobox protein DLX-4 (sprot)

description: A homeobox protein DLX-4 that is encoded in the genome of human.


name: CLP1_HUMAN Polyribonucleotide 5'-hydroxyl-kinase Clp1 (sprot)

description: A pre-mRNA cleavage complex II protein Clp1 that is encoded in the genome of human.


tRNA-intron endonuclease complex

description: A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.


GLMN_HUMAN Glomulin (sprot)

A glomulin that is encoded in the genome of human.


name: hepatocyte growth factor receptor binding

description: Binding to an hepatocyte growth factor receptor.


name: KAT5_HUMAN Histone acetyltransferase KAT5 (sprot)

description: A histone acetyltransferase KAT5 that is encoded in the genome of human.


name: histone H2AK5 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5).


peptide crotonyltransferase activity

description: Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide.


name: piccolo histone acetyltransferase complex

description: A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p.


Swr1 complex

description: A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.


name: TF3B_HUMAN Transcription factor IIIB 90 kDa subunit (sprot)

description: A transcription factor IIIB 90 kDa subunit that is encoded in the genome of human.


name: transcription preinitiation complex assembly

description: The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides.


transcription factor TFIIIB complex

description: A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF.


name: UBP13_HUMAN Ubiquitin carboxyl-terminal hydrolase 13 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 13 that is encoded in the genome of human.


name: DVL3_HUMAN Segment polarity protein dishevelled homolog DVL-3 (sprot)

description: A segment polarity protein dishevelled DVL-3 that is encoded in the genome of human.


name: USP9X_HUMAN Ubiquitin carboxyl-terminal hydrolase 9X (sprot)

description: A probable ubiquitin carboxyl-terminal hydrolase FAF-X that is encoded in the genome of human.


K11-linked deubiquitinase activity

description: Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys11 residue of ubiquitin.


name: UBP7_HUMAN Ubiquitin carboxyl-terminal hydrolase 7 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 7 that is encoded in the genome of human.


regulation of telomere capping

description: Any process that modulates the frequency, rate or extent of telomere capping.


name: NAA80_HUMAN N-alpha-acetyltransferase 80 (sprot)

description: An N-alpha-acetyltransferase 80 that is encoded in the genome of human.


name: IGSF2_HUMAN Immunoglobulin superfamily member 2 (sprot)

description: An immunoglobulin superfamily member 2 that is encoded in the genome of human.


name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

description: Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide.


CUL5_HUMAN Cullin-5 (sprot)

A cullin-5 that is encoded in the genome of human.


name: TNR25_HUMAN Tumor necrosis factor receptor superfamily member 25 (sprot)

description: A tumor necrosis factor receptor superfamily member 25 that is encoded in the genome of human.


STMN2_HUMAN Stathmin-2 (sprot)

A stathmin-2 that is encoded in the genome of human.


name: positive regulation of microtubule depolymerization

description: Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.


name: VPP1_HUMAN V-type proton ATPase 116 kDa subunit a 1 (sprot)

description: A V-type proton ATPase 116 kDa subunit a 1 that is encoded in the genome of human.


name: LPP_HUMAN Lipoma-preferred partner (sprot)

description: A lipoma-preferred partner that is encoded in the genome of human.


name: RBPMS_HUMAN RNA-binding protein with multiple splicing (sprot)

description: An RNA-binding protein with multiple splicing that is encoded in the genome of human.


mRNA CDS binding

description: Binding to an mRNA molecule coding sequence (CDS).


EXT2_HUMAN Exostosin-2 (sprot)

An exostosin-2 that is encoded in the genome of human.


name: NAR4_HUMAN Ecto-ADP-ribosyltransferase 4 (sprot)

description: An ecto-ADP-ribosyltransferase 4 that is encoded in the genome of human.


name: SBP2L_HUMAN Selenocysteine insertion sequence-binding protein 2-like (sprot)

description: A selenocysteine insertion sequence-binding protein 2-like that is encoded in the genome of human.


name: MED12_HUMAN Mediator of RNA polymerase II transcription subunit 12 (sprot)

description: A mediator of RNA polymerase II transcription subunit 12 that is encoded in the genome of human.


name: TATD2_HUMAN Putative deoxyribonuclease TATDN2 (sprot)

description: A putative deoxyribonuclease TATDN2 that is encoded in the genome of human.


name: H2A1C_HUMAN Histone H2A type 1-C (sprot)

description: A histone H2A type 1-C that is encoded in the genome of human.


name: H2B1H_HUMAN Histone H2B type 1-H (sprot)

description: A histone H2B type 1-H that is encoded in the genome of human.


MT1L_HUMAN Metallothionein-1L (sprot)

A metallothionein-1L that is encoded in the genome of human.


name: AT2A3_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (sprot)

description: A sarcoplasmic/endoplasmic reticulum calcium ATPase 3 that is encoded in the genome of human.


P2RX5_HUMAN P2X purinoceptor 5 (sprot)

A P2X purinoceptor 5 that is encoded in the genome of human.


ATP-gated ion channel activity

description: Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts.


name: BHMT1_HUMAN Betaine--homocysteine S-methyltransferase 1 (sprot)

description: A betaine--homocysteine S-methyltransferase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine.


amino-acid betaine metabolic process

description: The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid.


amino-acid betaine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid.


name: regulation of homocysteine metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid.


name: 'de novo' L-methionine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components.


L-methionine salvage

description: Any process that generates L-methionine from derivatives of it, without de novo synthesis.


RNAS6_HUMAN Ribonuclease K6 (sprot)

A ribonuclease K6 that is encoded in the genome of human.


name: TP4A1_HUMAN Protein tyrosine phosphatase type IVA 1 (sprot)

description: A protein tyrosine phosphatase type IVA 1 that is encoded in the genome of human.


WNT2B_HUMAN Protein Wnt-2b (sprot)

A protein Wnt-2b that is encoded in the genome of human.


WNT8B_HUMAN Protein Wnt-8b (sprot)

A protein Wnt-8b that is encoded in the genome of human.


name: HGD_HUMAN Homogentisate 1,2-dioxygenase (sprot)

description: A homogentisate 1,2-dioxygenase that is encoded in the genome of human.


homogentisate 1,2-dioxygenase activity

description: Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+.


name: KPBB_HUMAN Phosphorylase b kinase regulatory subunit beta (sprot)

description: A phosphorylase b kinase regulatory subunit beta that is encoded in the genome of human.


name: HMR1_HUMAN Major histocompatibility complex class I-related gene protein (sprot)

description: An MHC class I-related gene protein that is encoded in the genome of human.


name: positive regulation of T cell mediated cytotoxicity directed against tumor cell target

description: Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target.


name: TSLP_HUMAN Thymic stromal lymphopoietin (sprot)

description: A thymic stromal lymphopoietin that is encoded in the genome of human.


name: positive regulation of chemokine (C-C motif) ligand 1 production

description: Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1.


name: LEAP2_HUMAN Liver-expressed antimicrobial peptide 2 (sprot)

description: A liver-expressed antimicrobial peptide 2 that is encoded in the genome of human.


name: SCAM4_HUMAN Secretory carrier-associated membrane protein 4 (sprot)

description: A secretory carrier-associated membrane protein 4 that is encoded in the genome of human.


UCN3_HUMAN Urocortin-3 (sprot)

A urocortin-3 that is encoded in the genome of human.


name: corticotropin-releasing hormone receptor binding

description: Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland.


name: TCAL3_HUMAN Transcription elongation factor A protein-like 3 (sprot)

description: A transcription elongation factor A protein-like 3 that is encoded in the genome of human.


name: TSR2_HUMAN Pre-rRNA-processing protein TSR2 homolog (sprot)

description: A pre-rRNA-processing protein TSR2 that is encoded in the genome of human.


name: FATE1_HUMAN Fetal and adult testis-expressed transcript protein (sprot)

description: A fetal and adult testis-expressed transcript protein that is encoded in the genome of human.


name: TF3C6_HUMAN General transcription factor 3C polypeptide 6 (sprot)

description: A general transcription factor 3C polypeptide 6 that is encoded in the genome of human.


name: NKD2_HUMAN Protein naked cuticle homolog 2 (sprot)

description: A protein naked cuticle homolog 2 that is encoded in the genome of human.


KISSR_HUMAN KiSS-1 receptor (sprot)

A KiSS-1 receptor that is encoded in the genome of human.


name: HPS3_HUMAN BLOC-2 complex member HPS3 (sprot)

description: A BLOC-2 complex member HPS3 that is encoded in the genome of human.


name: LHX4_HUMAN LIM/homeobox protein Lhx4 (sprot)

description: A LIM/homeobox protein Lhx4 that is encoded in the genome of human.


name: medial motor column neuron differentiation

description: The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate.


name: SMCE1_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (sprot)

description: A SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 that is encoded in the genome of human.


name: CAVN3_HUMAN Caveolae-associated protein 3 (sprot)

description: A caveolae-associated protein 3 that is encoded in the genome of human.


negative regulation of fermentation

description: Any process that stops, prevents or reduces the frequency, rate or extent of fermentation.


RIFK_HUMAN Riboflavin kinase (sprot)

A riboflavin kinase that is encoded in the genome of human.


name: positive regulation of NAD(P)H oxidase activity

description: Any process that activates or increases the activity of the enzyme NAD(P)H oxidase.


riboflavin kinase activity

description: Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+.


riboflavin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).


FMN biosynthetic process

description: The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase.


name: flavin adenine dinucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes.


name: NKD1_HUMAN Protein naked cuticle homolog 1 (sprot)

description: A protein naked cuticle homolog 1 that is encoded in the genome of human.


name: regulation of cell migration involved in somitogenic axis elongation

description: Any process that modulates the frequency, rate, or extent of the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation.


name: FBXW7_HUMAN F-box/WD repeat-containing protein 7 (sprot)

description: An F-box/WD repeat-containing protein 7 that is encoded in the genome of human.


name: negative regulation of SREBP signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway.


name: CNKR1_HUMAN Connector enhancer of kinase suppressor of ras 1 (sprot)

description: A connector enhancer of kinase suppressor of ras 1 that is encoded in the genome of human.


name: POP5_HUMAN Ribonuclease P/MRP protein subunit POP5 (sprot)

description: A ribonuclease P/MRP protein subunit POP5 that is encoded in the genome of human.


name: MYDGF_HUMAN Myeloid-derived growth factor (sprot)

description: A myeloid-derived growth factor that is encoded in the genome of human.


name: GLYL1_HUMAN Glycine N-acyltransferase-like protein 1 (sprot)

description: A glycine N-acyltransferase-like protein 1 that is encoded in the genome of human.


glutamine N-acyltransferase activity

description: Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine.


name: S38A4_HUMAN Sodium-coupled neutral amino acid transporter 4 (sprot)

description: A sodium-coupled neutral amino acid transporter 4 that is encoded in the genome of human.


name: neutral L-amino acid:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) = neutral L-amino acid(in) + Na+(in).


name: alanine:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in).


name: ZKSC4_HUMAN Zinc finger protein with KRAB and SCAN domains 4 (sprot)

description: A zinc finger protein with KRAB and SCAN domains 4 that is encoded in the genome of human.


name: BORC5_HUMAN BLOC-1-related complex subunit 5 (sprot)

description: A BLOC-1-related complex subunit 5 that is encoded in the genome of human.


name: I22R2_HUMAN Interleukin-22 receptor subunit alpha-2 (sprot)

description: An interleukin-22 receptor subunit alpha-2 that is encoded in the genome of human.


interleukin-22 binding

description: Binding to interleukin-22.


name: RNF34_HUMAN E3 ubiquitin-protein ligase RNF34 (sprot)

description: An E3 ubiquitin-protein ligase RNF34 that is encoded in the genome of human.


regulation of oxygen metabolic process

description: Any process that modulates the frequency, rate or extent of oxygen metabolic process.


name: ABTB1_HUMAN Ankyrin repeat and BTB/POZ domain-containing protein 1 (sprot)

description: An ankyrin repeat and BTB/POZ domain-containing protein 1 that is encoded in the genome of human.


name: TMM54_HUMAN Transmembrane protein 54 (sprot)

description: A transmembrane protein 54 that is encoded in the genome of human.


MAL2_HUMAN Protein MAL2 (sprot)

A protein MAL2 that is encoded in the genome of human.


name: LSM10_HUMAN U7 snRNA-associated Sm-like protein LSm10 (sprot)

description: A U7 snRNA-associated Sm-like protein LSm10 that is encoded in the genome of human.


name: TM40L_HUMAN Mitochondrial import receptor subunit TOM40B (sprot)

description: A mitochondrial import receptor subunit TOM40B that is encoded in the genome of human.


preprotein binding

description: Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing.


name: CXA10_HUMAN Gap junction alpha-10 protein (sprot)

description: A gap junction alpha-10 protein that is encoded in the genome of human.


YIPF5_HUMAN Protein YIPF5 (sprot)

A protein YIPF5 that is encoded in the genome of human.


name: UBE2F_HUMAN NEDD8-conjugating enzyme UBE2F (sprot)

description: A NEDD8-conjugating enzyme UBE2F that is encoded in the genome of human.


name: PIGT_HUMAN GPI transamidase component PIG-T (sprot)

description: A GPI transamidase component PIG-T that is encoded in the genome of human.


name: TAAR8_HUMAN Trace amine-associated receptor 8 (sprot)

description: A trace amine-associated receptor 8 that is encoded in the genome of human.


name: IGSF8_HUMAN Immunoglobulin superfamily member 8 (sprot)

description: An immunoglobulin superfamily member 8 that is encoded in the genome of human.


name: FBX32_HUMAN F-box only protein 32 (sprot)

description: An F-box only protein 32 that is encoded in the genome of human.


name: TOP1M_HUMAN DNA topoisomerase I, mitochondrial (sprot)

description: A DNA topoisomerase I, mitochondrial that is encoded in the genome of human.


name: RL36L_HUMAN Ribosomal protein eL42-like (sprot)

description: A ribosomal protein eL42-like that is encoded in the genome of human.


name: TRI63_HUMAN E3 ubiquitin-protein ligase TRIM63 (sprot)

description: An E3 ubiquitin-protein ligase TRIM63 that is encoded in the genome of human.


name: ARL11_HUMAN ADP-ribosylation factor-like protein 11 (sprot)

description: An ADP-ribosylation factor-like protein 11 that is encoded in the genome of human.


name: RAB24_HUMAN Ras-related protein Rab-24 (sprot)

description: A Ras-related protein Rab-24 that is encoded in the genome of human.


name: P2R3C_HUMAN Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (sprot)

description: A serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma that is encoded in the genome of human.


name: OSBP2_HUMAN Oxysterol-binding protein 2 (sprot)

description: An oxysterol-binding protein 2 that is encoded in the genome of human.


name: LMBL2_HUMAN Lethal(3)malignant brain tumor-like protein 2 (sprot)

description: A lethal(3)malignant brain tumor-like protein 2 that is encoded in the genome of human.


name: ITFG2_HUMAN KICSTOR complex protein ITFG2 (sprot)

description: A KICSTOR complex protein ITFG2 that is encoded in the genome of human.


name: S35B4_HUMAN Nucleotide sugar transporter SLC35B4 (sprot)

description: A nucleotide sugar transporter SLC35B4 that is encoded in the genome of human.


name: UDP-xylose transmembrane transporter activity

description: Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate.


UDP-xylose transmembrane transport

description: The directed movement of UDP-xylose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate.


name: NEIL2_HUMAN Endonuclease 8-like 2 (sprot)

description: An endonuclease 8-like 2 that is encoded in the genome of human.


name: ZN622_HUMAN Cytoplasmic 60S subunit biogenesis factor ZNF622 (sprot)

description: A cytoplasmic 60S subunit biogenesis factor ZNF622 that is encoded in the genome of human.


name: TM203_HUMAN Transmembrane protein 203 (sprot)

description: A transmembrane protein 203 that is encoded in the genome of human.


name: HDA10_HUMAN Polyamine deacetylase HDAC10 (sprot)

description: A polyamine deacetylase HDAC10 that is encoded in the genome of human.


acetylputrescine deacetylase activity

description: Catalysis of the reaction: N-acetylputrescine + H2O = acetate + putrescine.


acetylspermidine deacetylase activity

description: Catalysis of the reaction: N(8)-acetylspermidine + H2O = acetate + spermidine.


polyamine deacetylation

description: The modification of acetylpolyamine by the removal of acetyl groups.


spermidine deacetylation

description: The modification of acetylspermadine by the removal of acetyl groups.


name: RRF2M_HUMAN Ribosome-releasing factor 2, mitochondrial (sprot)

description: An elongation factor G 2, mitochondrial that is encoded in the genome of human.


mitochondrial translational elongation

description: The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion.


SNX21_HUMAN Sorting nexin-21 (sprot)

A sorting nexin-21 that is encoded in the genome of human.


name: UB2E3_HUMAN Ubiquitin-conjugating enzyme E2 E3 (sprot)

description: A ubiquitin-conjugating enzyme E2 E3 that is encoded in the genome of human.


name: 5NT3B_HUMAN 7-methylguanosine phosphate-specific 5'-nucleotidase (sprot)

description: A 7-methylguanosine phosphate-specific 5'-nucleotidase that is encoded in the genome of human.


name: WBP2_HUMAN WW domain-binding protein 2 (sprot)

description: A WW domain-binding protein 2 that is encoded in the genome of human.


name: FBXW5_HUMAN F-box/WD repeat-containing protein 5 (sprot)

description: An F-box/WD repeat-containing protein 5 that is encoded in the genome of human.


name: PSMG2_HUMAN Proteasome assembly chaperone 2 (sprot)

description: A proteasome assembly chaperone 2 that is encoded in the genome of human.


name: MCHR2_HUMAN Melanin-concentrating hormone receptor 2 (sprot)

description: A melanin-concentrating hormone receptor 2 that is encoded in the genome of human.


name: NCLN_HUMAN BOS complex subunit NCLN (sprot)

description: A BOS complex subunit NCLN that is encoded in the genome of human.


TEKT1_HUMAN Tektin-1 (sprot)

A tektin-1 that is encoded in the genome of human.


name: MUL1_HUMAN Mitochondrial ubiquitin ligase activator of NFKB 1 (sprot)

description: A mitochondrial ubiquitin ligase activator of NFKB 1 that is encoded in the genome of human.


name: MRTFA_HUMAN Myocardin-related transcription factor A (sprot)

description: A myocardin-related transcription factor A that is encoded in the genome of human.


name: SPTSA_HUMAN Serine palmitoyltransferase small subunit A (sprot)

description: A serine palmitoyltransferase small subunit A that is encoded in the genome of human.


name: ZDH16_HUMAN Palmitoyltransferase ZDHHC16 (sprot)

description: A palmitoyltransferase ZDHHC16 that is encoded in the genome of human.


VCF1_HUMAN Protein VCF1 (sprot)

A protein VCF1 that is encoded in the genome of human.


name: ZN566_HUMAN Zinc finger protein 566 (sprot)

description: A zinc finger protein 566 that is encoded in the genome of human.


PMEPA_HUMAN Protein TMEPAI (sprot)

A protein TMEPAI that is encoded in the genome of human.


RIPL2_HUMAN RILP-like protein 2 (sprot)

A RILP-like protein 2 that is encoded in the genome of human.


LFG3_HUMAN Protein lifeguard 3 (sprot)

A protein lifeguard 3 that is encoded in the genome of human.


name: negative regulation of Fas signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of Fas signaling pathway.


name: SIA7F_HUMAN Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (sprot)

description: An alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 that is encoded in the genome of human.


name: ERGI1_HUMAN Endoplasmic reticulum-Golgi intermediate compartment protein 1 (sprot)

description: An endoplasmic reticulum-Golgi intermediate compartment protein 1 that is encoded in the genome of human.


name: UTP4_HUMAN U3 small nucleolar RNA-associated protein 4 homolog (sprot)

description: A U3 small nucleolar RNA-associated protein 4 homolog that is encoded in the genome of human.


t-UTP complex

description: A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p.


name: NXPE3_HUMAN NXPE family member 3 (sprot)

description: An NXPE family member 3 that is encoded in the genome of human.


name: GTPB3_HUMAN tRNA modification GTPase GTPBP3, mitochondrial (sprot)

description: A tRNA modification GTPase GTPBP3, mitochondrial that is encoded in the genome of human.


name: FAKD4_HUMAN FAST kinase domain-containing protein 4 (sprot)

description: A FAST kinase domain-containing protein 4 that is encoded in the genome of human.


mitochondrial mRNA processing

description: Steps involved in processing precursor RNAs arising from transcription of operons in the mitochondrial genome into mature mRNAs.


name: MARC2_HUMAN Mitochondrial amidoxime reducing component 2 (sprot)

description: A mitochondrial amidoxime reducing component 2 that is encoded in the genome of human.


name: TR19L_HUMAN Tumor necrosis factor receptor superfamily member 19L (sprot)

description: A tumor necrosis factor receptor superfamily member 19L that is encoded in the genome of human.


name: PP14A_HUMAN Protein phosphatase 1 regulatory subunit 14A (sprot)

description: A protein phosphatase 1 regulatory subunit 14A that is encoded in the genome of human.


name: TSACC_HUMAN TSSK6-activating co-chaperone protein (sprot)

description: A TSSK6-activating co-chaperone protein that is encoded in the genome of human.


name: VATE2_HUMAN V-type proton ATPase subunit E 2 (sprot)

description: A V-type proton ATPase subunit E 2 that is encoded in the genome of human.


name: proton-transporting two-sector ATPase complex, catalytic domain

description: A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled.


name: H2B1A_HUMAN Histone H2B type 1-A (sprot)

description: A histone H2B type 1-A that is encoded in the genome of human.


name: TET5B_HUMAN Terminal nucleotidyltransferase 5B (sprot)

description: A terminal nucleotidyltransferase 5B that is encoded in the genome of human.


name: G3ST3_HUMAN Galactose-3-O-sulfotransferase 3 (sprot)

description: A galactose-3-O-sulfotransferase 3 that is encoded in the genome of human.


description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate.


galactose 3-O-sulfotransferase activity

description: Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc.


monosaccharide metabolic process

description: The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.


description: The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.


name: C102A_HUMAN Coiled-coil domain-containing protein 102A (sprot)

description: A coiled-coil domain-containing protein 102A that is encoded in the genome of human.


name: CK052_HUMAN Uncharacterized protein C11orf52 (sprot)

description: An uncharacterized protein C11orf52 that is encoded in the genome of human.


CPNE4_HUMAN Copine-4 (sprot)

A copine-4 that is encoded in the genome of human.


name: T106A_HUMAN Transmembrane protein 106A (sprot)

description: A transmembrane protein 106A that is encoded in the genome of human.


CD80 biosynthetic process

description: The chemical reactions and pathways resulting in the formation of CD80, a CD marker that occurs on antigen presenting cells such as activated B cells and monocytes that provides a co-stimulatory signal necessary for T cell activation and survival.


CD86 biosynthetic process

description: The chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival.


name: positive regulation of nitric oxide metabolic process

description: Any process that activates or increases the frequency, rate or extent of nitric oxide metabolic process.


F162A_HUMAN Protein FAM162A (sprot)

A protein FAM162A that is encoded in the genome of human.


name: SLAF9_HUMAN SLAM family member 9 (sprot)

description: A SLAM family member 9 that is encoded in the genome of human.


name: FUCT1_HUMAN GDP-fucose transporter 1 (sprot)

description: A GDP-fucose transporter 1 that is encoded in the genome of human.


name: GDP-fucose transmembrane transporter activity

description: Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate.


GDP-fucose import into Golgi lumen

description: The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate.


name: MYL11_HUMAN Myosin regulatory light chain 11 (sprot)

description: A myosin regulatory light chain 11 that is encoded in the genome of human.


name: CCD47_HUMAN PAT complex subunit CCDC47 (sprot)

description: A PAT complex subunit CCDC47 that is encoded in the genome of human.


name: RM24_HUMAN Large ribosomal subunit protein uL24m (sprot)

description: A large ribosomal subunit protein uL24m that is encoded in the genome of human.


name: RN166_HUMAN E3 ubiquitin-protein ligase RNF166 (sprot)

description: An E3 ubiquitin-protein ligase RNF166 that is encoded in the genome of human.


name: SPSB4_HUMAN SPRY domain-containing SOCS box protein 4 (sprot)

description: A SPRY domain-containing SOCS box protein 4 that is encoded in the genome of human.


MFRN2_HUMAN Mitoferrin-2 (sprot)

A mitoferrin-2 that is encoded in the genome of human.


name: ISL2_HUMAN Insulin gene enhancer protein ISL-2 (sprot)

description: An insulin gene enhancer protein ISL-2 that is encoded in the genome of human.


name: SYAP1_HUMAN Synapse-associated protein 1 (sprot)

description: A synapse-associated protein 1 that is encoded in the genome of human.


name: PAQR1_HUMAN Adiponectin receptor protein 1 (sprot)

description: An adiponectin receptor protein 1 that is encoded in the genome of human.


name: T53I1_HUMAN Tumor protein p53-inducible nuclear protein 1 (sprot)

description: A tumor protein p53-inducible nuclear protein 1 that is encoded in the genome of human.


name: cellular response to methyl methanesulfonate

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus.


name: TM230_HUMAN Transmembrane protein 230 (sprot)

description: A transmembrane protein 230 that is encoded in the genome of human.


name: RERG_HUMAN Ras-related and estrogen-regulated growth inhibitor (sprot)

description: A Ras-related and estrogen-regulated growth inhibitor that is encoded in the genome of human.


name: MALD3_HUMAN MARVEL domain-containing protein 3 (sprot)

description: A MARVEL domain-containing protein 3 that is encoded in the genome of human.


protein localization to cell junction

description: A process in which a protein is transported to, or maintained in, a location within a cell junction.


name: TRI52_HUMAN E3 ubiquitin-protein ligase TRIM52 (sprot)

description: An E3 ubiquitin-protein ligase TRIM52 that is encoded in the genome of human.


name: EXOC4_HUMAN Exocyst complex component 4 (sprot)

description: An exocyst complex component 4 that is encoded in the genome of human.


name: AZIN2_HUMAN Antizyme inhibitor 2 (sprot)

description: An antizyme inhibitor 2 that is encoded in the genome of human.


arginine decarboxylase activity

description: Catalysis of the reaction: L-arginine + H+ = agmatine + CO2.


agmatine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)). Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase.


granular vesicle

description: A cytoplasmic membrane-bounded vesicle of varying size, but usually larger than 45 nm, with an electron dense granular core, found in noradrenergic and peptidergic cells.


name: MGN2_HUMAN Protein mago nashi homolog 2 (sprot)

description: A protein mago nashi homolog 2 that is encoded in the genome of human.


name: P33MX_HUMAN Putative monooxygenase p33MONOX (sprot)

description: A putative monooxygenase p33MONOX that is encoded in the genome of human.


name: COQA1_HUMAN Collagen alpha-1(XXVI) chain (sprot)

description: A collagen alpha-1(XXVI) chain that is encoded in the genome of human.


collagen type XXVI trimer

description: A collagen homotrimer of alpha1(XXVI) chains.


name: EMID1_HUMAN EMI domain-containing protein 1 (sprot)

description: An EMI domain-containing protein 1 that is encoded in the genome of human.


name: TIP39_HUMAN Tuberoinfundibular peptide of 39 residues (sprot)

description: A tuberoinfundibular peptide of 39 residues that is encoded in the genome of human.


PTX4_HUMAN Pentraxin-4 (sprot)

A pentraxin-4 that is encoded in the genome of human.


name: RFT1_HUMAN Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 (sprot)

description: A protein RFT1 that is encoded in the genome of human.


glycolipid floppase activity

description: Catalysis of the movement of a glycolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.


glycolipid translocation

description: The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.


name: JKIP2_HUMAN Janus kinase and microtubule-interacting protein 2 (sprot)

description: A Janus kinase and microtubule-interacting protein 2 that is encoded in the genome of human.


name: ISOC2_HUMAN Isochorismatase domain-containing protein 2 (sprot)

description: An isochorismatase domain-containing protein 2 that is encoded in the genome of human.


name: NTAN1_HUMAN Protein N-terminal asparagine amidohydrolase (sprot)

description: A protein N-terminal asparagine amidohydrolase that is encoded in the genome of human.


name: protein-N-terminal asparagine amidohydrolase activity

description: Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein.


name: FERM2_HUMAN Fermitin family homolog 2 (sprot)

description: A fermitin family homolog 2 that is encoded in the genome of human.


name: KIFC2_HUMAN Kinesin-like protein KIFC2 (sprot)

description: A kinesin-like protein KIFC2 that is encoded in the genome of human.


name: PLPL2_HUMAN Patatin-like phospholipase domain-containing protein 2 (sprot)

description: A patatin-like phospholipase domain-containing protein 2 that is encoded in the genome of human.


name: FUBP1_HUMAN Far upstream element-binding protein 1 (sprot)

description: A far upstream element-binding protein 1 that is encoded in the genome of human.


name: TTC17_HUMAN Tetratricopeptide repeat protein 17 (sprot)

description: A tetratricopeptide repeat protein 17 that is encoded in the genome of human.


name: S2546_HUMAN Mitochondrial outer membrane protein SLC25A46 (sprot)

description: A mitochondrial outer membrane protein SLC25A46 that is encoded in the genome of human.


name: LRC59_HUMAN Leucine-rich repeat-containing protein 59 (sprot)

description: A leucine-rich repeat-containing protein 59 that is encoded in the genome of human.


name: SOSB2_HUMAN SOSS complex subunit B2 (sprot)

description: A SOSS complex subunit B2 that is encoded in the genome of human.


name: RAB7B_HUMAN Ras-related protein Rab-7b (sprot)

description: A Ras-related protein Rab-7b that is encoded in the genome of human.


name: CLUA1_HUMAN Clusterin-associated protein 1 (sprot)

description: A clusterin-associated protein 1 that is encoded in the genome of human.


name: VTI1A_HUMAN Vesicle transport through interaction with t-SNAREs homolog 1A (sprot)

description: A vesicle transport through interaction with t-SNAREs homolog 1A that is encoded in the genome of human.


name: ABC3D_HUMAN DNA dC->dU-editing enzyme APOBEC-3D (sprot)

description: A DNA dC->dU-editing enzyme APOBEC-3D that is encoded in the genome of human.


name: MRGRF_HUMAN Mas-related G-protein coupled receptor member F (sprot)

description: A Mas-related G-protein coupled receptor F that is encoded in the genome of human.


name: TM143_HUMAN Transmembrane protein 143 (sprot)

description: A transmembrane protein 143 that is encoded in the genome of human.


name: ACD_HUMAN Adrenocortical dysplasia protein homolog (sprot)

description: An adrenocortical dysplasia protein that is encoded in the genome of human.


telomere assembly

description: A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a telomere at a non-telomeric double-stranded DNA end. A telomere is a terminal region of a linear chromosome that includes telomeric DNA repeats and associated proteins.


segmentation

description: The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.


name: positive regulation of single-stranded telomeric DNA binding

description: Any process that increases the frequency, rate or extent of single-stranded telomeric DNA binding.


name: ZUP1_HUMAN Zinc finger-containing ubiquitin peptidase 1 (sprot)

description: A zinc finger-containing ubiquitin peptidase 1 that is encoded in the genome of human.


name: ESAM_HUMAN Endothelial cell-selective adhesion molecule (sprot)

description: An endothelial cell-selective adhesion molecule that is encoded in the genome of human.


name: CC74A_HUMAN Coiled-coil domain-containing protein 74A (sprot)

description: A coiled-coil domain-containing protein 74A that is encoded in the genome of human.


name: TM125_HUMAN Transmembrane protein 125 (sprot)

description: A transmembrane protein 125 that is encoded in the genome of human.


name: PBIP1_HUMAN Pre-B-cell leukemia transcription factor-interacting protein 1 (sprot)

description: A pre-B-cell leukemia transcription factor-interacting protein 1 that is encoded in the genome of human.


name: gene expression involved in extracellular matrix organization

description: Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form.


name: CIDEC_HUMAN Lipid transferase CIDEC (sprot)

description: A lipid transferase CIDEC that is encoded in the genome of human.


name: MCUR1_HUMAN Mitochondrial calcium uniporter regulator 1 (sprot)

description: A coiled-coil domain-containing protein 90A, mitochondrial that is encoded in the genome of human.


F131C_HUMAN Protein FAM131C (sprot)

A protein FAM131C that is encoded in the genome of human.


name: K1143_HUMAN Uncharacterized protein KIAA1143 (sprot)

description: An uncharacterized protein KIAA1143 that is encoded in the genome of human.


name: RPE_HUMAN Ribulose-phosphate 3-epimerase (sprot)

description: A ribulose-phosphate 3-epimerase that is encoded in the genome of human.


description: Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate.


name: E2F7_HUMAN Transcription factor E2F7 (sprot)

description: A transcription factor E2F7 that is encoded in the genome of human.


name: VOPP1_HUMAN WW domain binding protein VOPP1 (sprot)

description: A WW domain binding protein VOPP1 that is encoded in the genome of human.


name: VP33A_HUMAN Vacuolar protein sorting-associated protein 33A (sprot)

description: A vacuolar protein sorting-associated protein 33A that is encoded in the genome of human.


name: RAB37_HUMAN Ras-related protein Rab-37 (sprot)

description: A Ras-related protein Rab-37 that is encoded in the genome of human.


name: MIB2_HUMAN E3 ubiquitin-protein ligase MIB2 (sprot)

description: An E3 ubiquitin-protein ligase MIB2 that is encoded in the genome of human.


name: EME1_HUMAN Crossover junction endonuclease EME1 (sprot)

description: A crossover junction endonuclease EME1 that is encoded in the genome of human.


name: FKB10_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP10 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP10 that is encoded in the genome of human.


name: TTC28_HUMAN Tetratricopeptide repeat protein 28 (sprot)

description: A tetratricopeptide repeat protein 28 that is encoded in the genome of human.


name: EFMT3_HUMAN EEF1A lysine methyltransferase 3 (sprot)

description: An EEF1A lysine methyltransferase 3 that is encoded in the genome of human.


name: ISG20_HUMAN Interferon-stimulated gene 20 kDa protein (sprot)

description: An interferon-stimulated gene 20 kDa protein that is encoded in the genome of human.


name: R51A1_HUMAN RAD51-associated protein 1 (sprot)

description: A RAD51-associated protein 1 that is encoded in the genome of human.


D-loop DNA binding

description: Binding to a DNA D-loop. A D-loop is a three-stranded DNA structure formed by the invasion of a single DNA strand that base pairs with one strand of duplex DNA, while the rest of the double-stranded DNA does not unwind.


name: UBE2W_HUMAN Ubiquitin-conjugating enzyme E2 W (sprot)

description: A ubiquitin-conjugating enzyme E2 W that is encoded in the genome of human.


DACT3_HUMAN Dapper homolog 3 (sprot)

A dapper homolog 3 that is encoded in the genome of human.


name: TM45B_HUMAN Transmembrane protein 45B (sprot)

description: A transmembrane protein 45B that is encoded in the genome of human.


ARK2N_HUMAN Protein ARK2N (sprot)

A protein ARK2N that is encoded in the genome of human.


name: EXOS8_HUMAN Exosome complex component RRP43 (sprot)

description: An exosome complex component RRP43 that is encoded in the genome of human.


CLD23_HUMAN Claudin-23 (sprot)

A claudin-23 that is encoded in the genome of human.


name: AKTS1_HUMAN Proline-rich AKT1 substrate 1 (sprot)

description: A proline-rich AKT1 substrate 1 that is encoded in the genome of human.


name: TMM18_HUMAN Transmembrane protein 18 (sprot)

description: A transmembrane protein 18 that is encoded in the genome of human.


name: BORC7_HUMAN BLOC-1-related complex subunit 7 (sprot)

description: A BLOC-1-related complex subunit 7 that is encoded in the genome of human.


name: TOM6_HUMAN Mitochondrial import receptor subunit TOM6 homolog (sprot)

description: A mitochondrial import receptor subunit TOM6 that is encoded in the genome of human.


name: ZN428_HUMAN Zinc finger protein 428 (sprot)

description: A zinc finger protein 428 that is encoded in the genome of human.


name: ARRD3_HUMAN Arrestin domain-containing protein 3 (sprot)

description: An arrestin domain-containing protein 3 that is encoded in the genome of human.


negative regulation of heat generation

description: Any process that stops, prevents, or reduces the rate or extent of heat generation.


name: LENG9_HUMAN Leukocyte receptor cluster member 9 (sprot)

description: A leukocyte receptor cluster member 9 that is encoded in the genome of human.


name: TM186_HUMAN Transmembrane protein 186 (sprot)

description: A transmembrane protein 186 that is encoded in the genome of human.


name: RGMA_HUMAN Repulsive guidance molecule A (sprot)

description: A repulsive guidance molecule A that is encoded in the genome of human.


name: LDAF1_HUMAN Lipid droplet assembly factor 1 (sprot)

description: A lipid droplet assembly factor 1 that is encoded in the genome of human.


name: SH3K1_HUMAN SH3 domain-containing kinase-binding protein 1 (sprot)

description: An SH3 domain-containing kinase-binding protein 1 that is encoded in the genome of human.


name: CR3L1_HUMAN Cyclic AMP-responsive element-binding protein 3-like protein 1 (sprot)

description: A cyclic AMP-responsive element-binding protein 3-like protein 1 that is encoded in the genome of human.


name: SO4A1_HUMAN Solute carrier organic anion transporter family member 4A1 (sprot)

description: A solute carrier organic anion transporter family member 4A1 that is encoded in the genome of human.


name: PF21A_HUMAN PHD finger protein 21A (sprot)

description: A PHD finger protein 21A that is encoded in the genome of human.


name: SPSB1_HUMAN SPRY domain-containing SOCS box protein 1 (sprot)

description: A SPRY domain-containing SOCS box protein 1 that is encoded in the genome of human.


name: SKA1_HUMAN Spindle and kinetochore-associated protein 1 (sprot)

description: A spindle and kinetochore-associated protein 1 that is encoded in the genome of human.


name: TMIG2_HUMAN Transmembrane and immunoglobulin domain-containing protein 2 (sprot)

description: A transmembrane and immunoglobulin domain-containing protein 2 that is encoded in the genome of human.


name: NACC2_HUMAN Nucleus accumbens-associated protein 2 (sprot)

description: A nucleus accumbens-associated protein 2 that is encoded in the genome of human.


name: RNF25_HUMAN E3 ubiquitin-protein ligase RNF25 (sprot)

description: An E3 ubiquitin-protein ligase RNF25 that is encoded in the genome of human.


name: ESPB1_HUMAN Epididymal sperm-binding protein 1 (sprot)

description: An epididymal sperm-binding protein 1 that is encoded in the genome of human.


name: S22AI_HUMAN Solute carrier family 22 member 18 (sprot)

description: A solute carrier family 22 member 18 that is encoded in the genome of human.


name: APH1A_HUMAN Gamma-secretase subunit APH-1A (sprot)

description: A gamma-secretase subunit APH-1A that is encoded in the genome of human.


name: AIDA_HUMAN Axin interactor, dorsalization-associated protein (sprot)

description: An Axin interactor, dorsalization-associated protein that is encoded in the genome of human.


name: ELMO3_HUMAN Engulfment and cell motility protein 3 (sprot)

description: An engulfment and cell motility protein 3 that is encoded in the genome of human.


name: PINX1_HUMAN PIN2/TERF1-interacting telomerase inhibitor 1 (sprot)

description: A pin2-interacting protein X1 that is encoded in the genome of human.


name: positive regulation of telomeric DNA binding

description: Any process that activates or increases the frequency, rate or extent of telomeric DNA binding.


name: I27L1_HUMAN Interferon alpha-inducible protein 27-like protein 1 (sprot)

description: An interferon alpha-inducible protein 27-like protein 1 that is encoded in the genome of human.


name: ANKR9_HUMAN Ankyrin repeat domain-containing protein 9 (sprot)

description: An ankyrin repeat domain-containing protein 9 that is encoded in the genome of human.


name: ARL8A_HUMAN ADP-ribosylation factor-like protein 8A (sprot)

description: An ADP-ribosylation factor-like protein 8A that is encoded in the genome of human.


name: TADA1_HUMAN Transcriptional adapter 1 (sprot)

description: A transcriptional adapter 1-like protein that is encoded in the genome of human.


name: F149B_HUMAN Primary cilium assembly protein FAM149B1 (sprot)

description: A primary cilium assembly protein FAM149B1 that is encoded in the genome of human.


name: OTUL_HUMAN Ubiquitin thioesterase otulin (sprot)

description: A ubiquitin thioesterase otulin that is encoded in the genome of human.


protein linear deubiquitination

description: A protein deubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is removed from a protein.


LUBAC complex

description: A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex.


name: CHCH1_HUMAN Small ribosomal subunit protein mS37 (sprot)

description: A small ribosomal subunit protein mS37 that is encoded in the genome of human.


name: PPWD1_HUMAN Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (sprot)

description: A peptidylprolyl isomerase domain and WD repeat-containing protein 1 that is encoded in the genome of human.


FAM3D_HUMAN Protein FAM3D (sprot)

A protein FAM3D that is encoded in the genome of human.


name: TRI43_HUMAN Tripartite motif-containing protein 43 (sprot)

description: A tripartite motif-containing protein 43 that is encoded in the genome of human.


name: SGK3_HUMAN Serine/threonine-protein kinase Sgk3 (sprot)

description: A serine/threonine-protein kinase Sgk3 that is encoded in the genome of human.


name: COA7_HUMAN Cytochrome c oxidase assembly factor 7 (sprot)

description: A cytochrome c oxidase assembly factor 7 that is encoded in the genome of human.


name: ZN669_HUMAN Zinc finger protein 669 (sprot)

description: A zinc finger protein 669 that is encoded in the genome of human.


name: ZBT8A_HUMAN Zinc finger and BTB domain-containing protein 8A (sprot)

description: A zinc finger and BTB domain-containing protein 8A that is encoded in the genome of human.


name: CHP3_HUMAN Calcineurin B homologous protein 3 (sprot)

description: A calcineurin B homologous protein 3 that is encoded in the genome of human.


name: CENPT_HUMAN Centromere protein T (sprot)

description: A centromere protein T that is encoded in the genome of human.


name: ALKB8_HUMAN Alkylated DNA repair protein alkB homolog 8 (sprot)

description: An alkylated DNA repair protein alkB homolog 8 that is encoded in the genome of human.


name: tRNA (uridine) methyltransferase activity

description: Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule.


name: S1PBP_HUMAN S100P-binding protein (sprot)

description: An S100P-binding protein that is encoded in the genome of human.


name: ZN775_HUMAN Zinc finger protein 775 (sprot)

description: A zinc finger protein 775 that is encoded in the genome of human.


name: UPP_HUMAN Uracil phosphoribosyltransferase homolog (sprot)

description: A uracil phosphoribosyltransferase that is encoded in the genome of human.


name: PTER_HUMAN Phosphotriesterase-related protein (sprot)

description: A phosphotriesterase-related protein that is encoded in the genome of human.


name: TAM41_HUMAN Phosphatidate cytidylyltransferase, mitochondrial (sprot)

description: A phosphatidate cytidylyltransferase, mitochondrial that is encoded in the genome of human.


name: MOB3A_HUMAN MOB kinase activator 3A (sprot)

description: A MOB kinase activator 3A that is encoded in the genome of human.


name: MOAP1_HUMAN Modulator of apoptosis 1 (sprot)

description: A modulator of apoptosis 1 that is encoded in the genome of human.


name: DOC10_HUMAN Dedicator of cytokinesis protein 10 (sprot)

description: A dedicator of cytokinesis protein 10 that is encoded in the genome of human.


name: ATG2B_HUMAN Autophagy-related protein 2 homolog B (sprot)

description: An autophagy-related protein 2 homolog B that is encoded in the genome of human.


name: SARAF_HUMAN Store-operated calcium entry-associated regulatory factor (sprot)

description: A store-operated calcium entry-associated regulatory factor that is encoded in the genome of human.


name: PLD4_HUMAN 5'-3' exonuclease PLD4 (sprot)

description: A 5'-3' exonuclease PLD4 that is encoded in the genome of human.


name: LENG1_HUMAN Leukocyte receptor cluster member 1 (sprot)

description: A leukocyte receptor cluster member 1 that is encoded in the genome of human.


name: TBC20_HUMAN TBC1 domain family member 20 (sprot)

description: A TBC1 domain family member 20 that is encoded in the genome of human.


name: ZBTB9_HUMAN Zinc finger and BTB domain-containing protein 9 (sprot)

description: A zinc finger and BTB domain-containing protein 9 that is encoded in the genome of human.


F136A_HUMAN Protein FAM136A (sprot)

A protein FAM136A that is encoded in the genome of human.


name: MID49_HUMAN Mitochondrial dynamics protein MID49 (sprot)

description: A Smith-Magenis syndrome chromosome region candidate gene 7 protein that is encoded in the genome of human.


name: DHX58_HUMAN ATP-dependent RNA helicase DHX58 (sprot)

description: An ATP-dependent RNA helicase DHX58 that is encoded in the genome of human.