name: glutathione-dependent sulfide quinone oxidoreductase activity

description: Catalysis of the reaction: a quinone + glutathione + H+ + hydrogen sulfide = a quinol + S-sulfanylglutathione.


name: LAMC3_HUMAN Laminin subunit gamma-3 (sprot)

description: A laminin subunit gamma-3 that is encoded in the genome of human.


name: ROBO1_HUMAN Roundabout homolog 1 (sprot)

description: A roundabout homolog 1 that is encoded in the genome of human.


CAD10_HUMAN Cadherin-10 (sprot)

A cadherin-10 that is encoded in the genome of human.


USH1C_HUMAN Harmonin (sprot)

A harmonin that is encoded in the genome of human.


SESN1_HUMAN Sestrin-1 (sprot)

A sestrin-1 that is encoded in the genome of human.


CAN6_HUMAN Calpain-6 (sprot)

A calpain-6 that is encoded in the genome of human.


STON1_HUMAN Stonin-1 (sprot)

A stonin-1 that is encoded in the genome of human.


name: ZFP37_HUMAN Zinc finger protein 37 homolog (sprot)

description: A zinc finger protein 37 that is encoded in the genome of human.


name: AP1M2_HUMAN AP-1 complex subunit mu-2 (sprot)

description: An AP-1 complex subunit mu-2 that is encoded in the genome of human.


name: TNR11_HUMAN Tumor necrosis factor receptor superfamily member 11A (sprot)

description: A tumor necrosis factor receptor superfamily member 11A that is encoded in the genome of human.


name: NCOA3_HUMAN Nuclear receptor coactivator 3 (sprot)

description: A nuclear receptor coactivator 3 that is encoded in the genome of human.


NUMBL_HUMAN Numb-like protein (sprot)

A Numb-like protein that is encoded in the genome of human.


name: S4A4_HUMAN Electrogenic sodium bicarbonate cotransporter 1 (sprot)

description: An electrogenic sodium bicarbonate cotransporter 1 that is encoded in the genome of human.


name: M3K4_HUMAN Mitogen-activated protein kinase kinase kinase 4 (sprot)

description: A mitogen-activated protein kinase kinase kinase 4 that is encoded in the genome of human.


name: Z780B_HUMAN Zinc finger protein 780B (sprot)

description: A zinc finger protein 780B that is encoded in the genome of human.


name: FCGBP_HUMAN IgGFc-binding protein (sprot)

description: An IgGFc-binding protein that is encoded in the genome of human.


name: CCD61_HUMAN Centrosomal protein CCDC61 (sprot)

description: A centrosomal protein CCDC61 that is encoded in the genome of human.


name: RPKL1_HUMAN Ribosomal protein S6 kinase-like 1 (sprot)

description: A ribosomal protein S6 kinase-like 1 that is encoded in the genome of human.


name: DGKB_HUMAN Diacylglycerol kinase beta (sprot)

description: A diacylglycerol kinase beta that is encoded in the genome of human.


SCIN_HUMAN Scinderin (sprot)

A scinderin that is encoded in the genome of human.


name: RN215_HUMAN RING finger protein 215 (sprot)

description: A RING finger protein 215 that is encoded in the genome of human.


PCLO_HUMAN Protein piccolo (sprot)

A protein piccolo that is encoded in the genome of human.


name: DDX49_HUMAN Probable ATP-dependent RNA helicase DDX49 (sprot)

description: A probable ATP-dependent RNA helicase DDX49 that is encoded in the genome of human.


regulation of rRNA stability

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that modulates the propensity of rRNA molecules to degradation. Includes processes that both stabilize and destabilize rRNAs.


CAN7_HUMAN Calpain-7 (sprot)

A calpain-7 that is encoded in the genome of human.


name: WASF2_HUMAN Actin-binding protein WASF2 (sprot)

description: An actin-binding protein WASF2 that is encoded in the genome of human.


name: DUS10_HUMAN Dual specificity protein phosphatase 10 (sprot)

description: A dual specificity protein phosphatase 10 that is encoded in the genome of human.


name: negative regulation of epithelium regeneration

description: Any process that stops, prevents or reduces the frequency, rate or extent of epithelium regeneration.


name: ICOS_HUMAN Inducible T-cell costimulator (sprot)

description: An inducible T-cell costimulator that is encoded in the genome of human.


SETBP_HUMAN SET-binding protein (sprot)

A SET-binding protein that is encoded in the genome of human.


name: SERP1_HUMAN Stress-associated endoplasmic reticulum protein 1 (sprot)

description: A stress-associated endoplasmic reticulum protein 1 that is encoded in the genome of human.


name: PIAS3_HUMAN E3 SUMO-protein ligase PIAS3 (sprot)

description: An E3 SUMO-protein ligase PIAS3 that is encoded in the genome of human.


name: SCC4_HUMAN MAU2 chromatid cohesion factor homolog (sprot)

description: A MAU2 chromatid cohesion factor homolog that is encoded in the genome of human.


name: F169A_HUMAN Soluble lamin-associated protein of 75 kDa (sprot)

description: A soluble lamin-associated protein of 75 kDa that is encoded in the genome of human.


name: ENPP4_HUMAN Bis(5'-adenosyl)-triphosphatase ENPP4 (sprot)

description: A bis(5'-adenosyl)-triphosphatase ENPP4 that is encoded in the genome of human.


purine ribonucleoside catabolic process

description: The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule.


name: MYO16_HUMAN Unconventional myosin-XVI (sprot)

description: A myosin-XVI that is encoded in the genome of human.


name: ZHX2_HUMAN Zinc fingers and homeoboxes protein 2 (sprot)

description: A zinc fingers and homeoboxes protein 2 that is encoded in the genome of human.


MORC2_HUMAN ATPase MORC2 (sprot)

An ATPase MORC2 that is encoded in the genome of human.


name: NS1BP_HUMAN Influenza virus NS1A-binding protein (sprot)

description: An influenza virus NS1A-binding protein that is encoded in the genome of human.


name: CMTA1_HUMAN Calmodulin-binding transcription activator 1 (sprot)

description: A calmodulin-binding transcription activator 1 that is encoded in the genome of human.


name: S23IP_HUMAN SEC23-interacting protein (sprot)

description: A SEC23-interacting protein that is encoded in the genome of human.


name: LY96_HUMAN Lymphocyte antigen 96 (sprot)

description: A lymphocyte antigen 96 that is encoded in the genome of human.


name: CF123_HUMAN Uncharacterized protein encoded by LINC01558 (sprot)

description: A protein that is a translation product of the LINC01558 gene in human.


name: KIAS1_HUMAN Putative uncharacterized protein KIF25-AS1 (sprot)


name: AFDDT_HUMAN Putative uncharacterized protein AFDN-DT (sprot)


COL10_HUMAN Collectin-10 (sprot)

A collectin-10 that is encoded in the genome of human.


name: GAK19_HUMAN Endogenous retrovirus group K member 19 Gag polyprotein (sprot)


name: S4R3C0_HUMAN Immunoglobulin heavy variable 3/OR16-17 (non-functional) (Fragment) (trembl)


HMN13_HUMAN Humanin-like 13 (sprot)

A protein that is a translation product of the MTRNR2L13 gene in human.


HMN11_HUMAN Humanin-like 11 (sprot)

A protein that is a translation product of the MTRNR2L11 gene in human.


name: A3LT2_HUMAN Alpha-1,3-galactosyltransferase 2 (sprot)

description: An alpha-1,3-galactosyltransferase 2 that is encoded in the genome of human.


category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP.


name: SACA6_HUMAN Sperm acrosome membrane-associated protein 6 (sprot)

description: A sperm acrosome membrane-associated protein 6 that is encoded in the genome of human.


name: PYDC5_HUMAN Pyrin domain-containing protein 5 (sprot)

description: A protein that is a translation product of the PYDC5 gene in human.


name: termination of RNA polymerase III transcription

description: A transcription termination process that completes the production of a primary RNA polymerase II transcript. RNA polymerase III has an intrinsic ability to terminate transcription upon incorporation of at least 4 contiguous U residues.


synaptic signaling

description: Cell-cell signaling to, from or within a synapse.


tRNA-intron endonuclease activity

description: Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.


name: tRNA-type intron splice site recognition and cleavage

description: RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs.


description: Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine.


ribonuclease MRP activity

description: Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA.


septin ring organization

description: Control of the formation, spatial distribution, and breakdown of the septin ring.


description: Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA.


meiotic DNA recombinase assembly

description: During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA.


proteasome core complex assembly

description: The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles.


pre-mRNA 5'-splice site binding

description: Binding to a pre-mRNA 5' splice site sequence.


ribonuclease P complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs.


response to oxygen levels

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.


name: LRC66_HUMAN Leucine-rich repeat-containing protein 66 (sprot)

description: A leucine-rich repeat-containing protein 66 that is encoded in the genome of human.


Noc1p-Noc2p complex

description: A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis.


name: single-strand break-containing DNA binding

description: Binding to damaged DNA containing single-strand breaks (SSBs).


name: FKB1C_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1C (sprot)

description: A protein that is a translation product of the FKBP1C gene in human.


name: A0A0G2JMM0_HUMAN Uncharacterized protein (trembl)


name: A0A191URJ7_HUMAN KIR2DL protein (trembl)


name: arginine biosynthetic process via ornithine

description: The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.


name: VWDE_HUMAN von Willebrand factor D and EGF domain-containing protein (sprot)

description: A von Willebrand factor D and EGF domain-containing protein that is encoded in the genome of human.


name: STMD1_HUMAN Stathmin domain-containing protein 1 (sprot)

description: A stathmin domain-containing protein 1 that is encoded in the genome of human.


name: DUX3_HUMAN Putative double homeobox protein 3 (sprot)

description: A putative double homeobox protein 3 that is encoded in the genome of human.


name: MAP kinase tyrosine phosphatase activity

description: Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate.


name: MA7D2_HUMAN MAP7 domain-containing protein 2 (sprot)

description: A MAP7 domain-containing protein 2 that is encoded in the genome of human.


name: cellular response to nitrogen starvation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen.


fumarylacetoacetase activity

description: Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+.


name: GOG8Q_HUMAN Golgin subfamily A member 8Q (sprot)

description: A protein that is a translation product of the GOLGA8Q gene in human.


MRCOL_HUMAN MARCO-like protein (sprot)

A protein that is a translation product of the MARCOL gene in human.


large ribosomal subunit rRNA binding

description: Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA.


glucagon receptor binding

description: Binding to a glucagon receptor.


isoleucine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.


phenylacetate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of phenylacetate.


name: AN34A_HUMAN Ankyrin repeat domain-containing protein 34A (sprot)

description: An ankyrin repeat domain-containing protein 34A that is encoded in the genome of human.


D-serine transmembrane transport

description: The process in which of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid is transported across a lipid bilayer, from one side of a membrane to the other, by means of some agent such as a transporter or pore.


piecemeal microautophagy of the nucleus

description: Degradation of a cell nucleus by microautophagy.


name: A0A5K1VDZ0_HUMAN KIR2DL1 protein (trembl)


name: granulocyte colony-stimulating factor receptor binding

description: Binding to a granulocyte colony-stimulating factor receptor.


Mis6-Sim4 complex

description: A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.


nuclear pore inner ring

description: A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex.


nonfunctional rRNA decay

description: An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system.


name: HNRC4_HUMAN Heterogeneous nuclear ribonucleoprotein C-like 4 (sprot)

description: A protein that is a translation product of the HNRNPCL4 gene in human.


name: isopentenyl diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids.


SPDE1_HUMAN Speedy protein E1 (sprot)

A speedy protein E1 that is encoded in the genome of human.


immunoglobulin production

description: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


cytokine production

description: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


name: CLBA1_HUMAN Uncharacterized protein CLBA1 (sprot)

description: An uncharacterized protein CLBA1 that is encoded in the genome of human.


peptide receptor activity

description: Combining with an extracellular or intracellular peptide to initiate a change in cell activity.


name: GOG8T_HUMAN Golgin subfamily A member 8T (sprot)

description: A protein that is a translation product of the GOLGA8T gene in human.


name: PAL4C_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4C (sprot)

description: A protein that is a translation product of the PPIAL4C gene in human.


name: A0A1B0GW55_HUMAN Homeobox domain-containing protein (trembl)


name: KAL1L_HUMAN KAT8 regulatory NSL complex subunit 1-like protein (sprot)

description: A KAT8 regulatory NSL complex subunit 1-like protein that is encoded in the genome of human.


name: mitotic actomyosin contractile ring assembly actin filament organization

description: Any actin filament organization that is involved in mitotic actomyosin contractile ring assembly.


name: VGLL3_HUMAN Transcription cofactor vestigial-like protein 3 (sprot)

description: A transcription cofactor vestigial-like protein 3 that is encoded in the genome of human.


name: G32P1_HUMAN Putative G-protein coupled receptor GPR32P1 (sprot)


name: RGPD3_HUMAN RanBP2-like and GRIP domain-containing protein 3 (sprot)

description: A RanBP2-like and GRIP domain-containing protein 3 that is encoded in the genome of human.


hemoglobin alpha binding

description: Binding to a hemoglobin alpha chain.


name: LITAD_HUMAN LITAF domain-containing protein (sprot)


name: CFA97_HUMAN Cilia- and flagella-associated protein 97 (sprot)

description: A cilia- and flagella-associated protein 97 that is encoded in the genome of human.


maturation of LSU-rRNA

description: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule.


name: MB3L4_HUMAN Putative methyl-CpG-binding domain protein 3-like 4 (sprot)


name: Golgi to plasma membrane transport vesicle

description: A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.


cellular response to stress

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


embryo development

description: The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.


name: ME3L2_HUMAN Putative homeobox protein Meis3-like 2 (sprot)

description: A putative homeobox protein Meis3-like 2 that is encoded in the genome of human.


name: LHPL6_HUMAN LHFPL tetraspan subfamily member 6 protein (sprot)

description: An LHFPL tetraspan subfamily member 6 protein that is encoded in the genome of human.


name: A0A2R8Y5M8_HUMAN catechol O-methyltransferase (trembl)


name: VSXL2_HUMAN V-set and immunoglobulin domain-containing protein 10-like 2 (sprot)

description: A V-set and immunoglobulin domain-containing protein 10-like 2 that is encoded in the genome of human.


name: disruption of plasma membrane integrity in another organism

description: The disruption of the cell membrane of another organism, leading to damage or temporary subversion of the membrane.


animal organ development

description: Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


immunoglobulin complex, circulating

description: An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.


name: IGFL4_HUMAN Insulin growth factor-like family member 4 (sprot)

description: An insulin growth factor-like family member 4 that is encoded in the genome of human.


name: adenosine 5'-(hexahydrogen pentaphosphate) catabolic process

description: The chemical reactions and pathways resulting in the breakdown of adenosine 5'-(hexahydrogen pentaphosphate).


name: TRAMP-dependent tRNA surveillance pathway

description: A nuclear tRNA surveillance pathway, dependent on the TRAMP exosome adaptor and the nuclear exosome.


name: GPR33_HUMAN Probable G-protein coupled receptor 33 (sprot)

description: A probable G-protein coupled receptor 33 that is encoded in the genome of human.


name: RMXL3_HUMAN RNA-binding motif protein, X-linked-like-3 (sprot)

description: An RNA-binding motif protein, X-linked-like-3 that is encoded in the genome of human.


name: regulation of establishment of bipolar cell polarity

description: Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane.


name: PLS5_HUMAN Phospholipid scramblase family member 5 (sprot)

description: A phospholipid scramblase family member 5 that is encoded in the genome of human.


intracellular anatomical structure

description: A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.


name: A0A0G2JNG1_HUMAN Killer cell immunoglobulin-like receptor 2DS5 (trembl)


description: The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.


name: GOG8C_HUMAN Golgin subfamily A member 8C (sprot)


AB12B_HUMAN Protein ABHD12B (sprot)

A protein ABHD12B that is encoded in the genome of human.


name: MRFL_HUMAN Myelin regulatory factor-like protein (sprot)

description: A myelin regulatory factor-like protein that is encoded in the genome of human.


mitotic G1 phase

description: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.


AMPQ_HUMAN Aminopeptidase Q (sprot)

A laeverin that is encoded in the genome of human.


name: equatorial microtubule organizing center

description: A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis.


anatomical structure development

description: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.


name: oligosaccharide-lipid intermediate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation.


name: PRS54_HUMAN Inactive serine protease 54 (sprot)

description: An inactive serine protease 54 that is encoded in the genome of human.


name: RGF1C_HUMAN Ras-GEF domain-containing family member 1C (sprot)

description: A Ras-GEF domain-containing family member 1C that is encoded in the genome of human.


name: HDHD5_HUMAN Haloacid dehalogenase-like hydrolase domain-containing 5 (sprot)

description: A haloacid dehalogenase-like hydrolase domain-containing 5 that is encoded in the genome of human.


name: HSFX4_HUMAN Heat shock transcription factor, X-linked member 4 (sprot)

description: A protein that is a translation product of the HSFX4 gene in human.


name: DE10B_HUMAN Putative DENN domain-containing protein 10 B (sprot)

description: A putative DENN domain-containing protein 10 B that is encoded in the genome of human.


sarcosine dehydrogenase activity

description: Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein.


name: PAB4L_HUMAN Polyadenylate-binding protein 4-like (sprot)

description: A polyadenylate-binding protein 4-like that is encoded in the genome of human.


diphthine methylesterase activity

description: Catalysis of the reaction: diphthine methyl ester + H2O = diphthine + H+ + methanol.


name: RHN2P_HUMAN Putative rhophilin-2-like protein RHPN2P1 (sprot)


name: post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery

description: The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed.


name: TSNA1_HUMAN t-SNARE domain-containing protein 1 (sprot)

description: A t-SNARE domain-containing protein 1 that is encoded in the genome of human.


dense core granule priming

description: A process that converts unprimed dense core granules (DCVs) to a pool of primed vesicles that are capable of fusing with the plasma membrane (fusion-competent) and thereby releasing their contents. Priming typically occurs after docking.


name: DC8L2_HUMAN DDB1- and CUL4-associated factor 8-like protein 2 (sprot)

description: A DDB1- and CUL4-associated factor 8-like protein 2 that is encoded in the genome of human.


name: SAM14_HUMAN Sterile alpha motif domain-containing protein 14 (sprot)

description: A sterile alpha motif domain-containing protein 14 that is encoded in the genome of human.


name: DPCA2_HUMAN Putative Dresden prostate carcinoma protein 2 (sprot)


name: ZY11A_HUMAN Protein zyg-11 homolog A (sprot)

description: A protein zyg-11 homolog A that is encoded in the genome of human.


name: PAL4G_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4G (sprot)

description: A peptidyl-prolyl cis-trans isomerase A-like 4G that is encoded in the genome of human.


description: H2O + L-glutamate 5-semialdehyde + NAD+ = 2 H+ + L-glutamate + NADH.


name: MANS4_HUMAN MANSC domain-containing protein 4 (sprot)

description: A MANSC domain-containing protein 4 that is encoded in the genome of human.


cytotoxic T cell differentiation

description: The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell.


SEM3D_HUMAN Semaphorin-3D (sprot)

A semaphorin-3D that is encoded in the genome of human.


name: GBG14_HUMAN Putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 (sprot)


name: CPHL2_HUMAN Cytoplasmic polyadenylated homeobox-like protein 2 (sprot)

description: A protein that is a translation product of the CPHXL2 gene in human.


name: A0A0G2JLM5_HUMAN Killer cell immunoglobulin-like receptor 2DS5 (trembl)


GID complex

description: A protein complex with ubiquitin ligase activity that, in Saccharomyces cerevisiae, is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. It appears to play a broader role in cellular homeostasis and development in other species.


MWP complex

description: A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin.


name: UBE3B_HUMAN Ubiquitin-protein ligase E3B (sprot)

description: A ubiquitin-protein ligase E3B that is encoded in the genome of human.


SYT15_HUMAN Synaptotagmin-15 (sprot)

A synaptotagmin-15 that is encoded in the genome of human.


name: A0A0G2JQ47_HUMAN Killer cell immunoglobulin-like receptor 2DS1 (trembl)


name: MOXD2_HUMAN Putative DBH-like monooxygenase protein 2 (sprot)


JUN kinase phosphatase activity

description: Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate.


name: A0A0G2JNF4_HUMAN Killer cell immunoglobulin-like receptor, two Ig domains pseudogene 1 (trembl)


name: SPD14_HUMAN Putative speedy protein E14 (sprot)


name: MS4A5_HUMAN Membrane-spanning 4-domains subfamily A member 5 (sprot)

description: A membrane-spanning 4-domains subfamily A member 5 that is encoded in the genome of human.


name: synaptic vesicle budding from presynaptic endocytic zone membrane

description: Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle.


transport

description: The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.


name: intracellular cyclic nucleotide activated cation channel complex

description: A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts.


name: VTM2B_HUMAN V-set and transmembrane domain-containing protein 2B (sprot)

description: A V-set and transmembrane domain-containing protein 2B that is encoded in the genome of human.


name: DNA strand elongation involved in mitotic DNA replication

description: Any DNA strand elongation involved in mitotic cell cycle DNA replication.


name: putative ubiquitin carboxyl-terminal hydrolase 41 (human)

description: A putative ubiquitin carboxyl-terminal hydrolase 41 that is encoded in the genome of human.


name: LRC43_HUMAN Leucine-rich repeat-containing protein 43 (sprot)

description: A leucine-rich repeat-containing protein 43 that is encoded in the genome of human.


name: neurotransmitter receptor transport postsynaptic membrane to endosome

description: Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome.


CRGN_HUMAN Gamma-crystallin N (sprot)

A gamma-crystallin N that is encoded in the genome of human.


RNA polymerase III activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


name: MRGX4_HUMAN Mas-related G-protein coupled receptor member X4 (sprot)

description: A Mas-related G-protein coupled receptor X4 that is encoded in the genome of human.


name: oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

description: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water.


name: A0A075B6H5_HUMAN T cell receptor beta variable 20/OR9-2 (non-functional) (Fragment) (trembl)


name: positive regulation of glutamate-cysteine ligase activity

description: Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate.


muscle cell fate specification

description: The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


CDP-glycerol diphosphatase activity

description: Catalysis of the reaction: CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H+.


name: PRT1B_HUMAN Proline rich transmembrane protein 1B (sprot)

description: A protein that is a translation product of the PRRT1B gene in human.


Fer-1-like protein 4 (human)

A Fer-1-like protein 4 that is encoded in the genome of human.


name: positive regulation of somatostatin secretion

description: Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.


transcription regulator activity

description: A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons.


name: PT100_HUMAN Protein PET100 homolog, mitochondrial (sprot)

description: A protein PET100 homolog, mitochondrial that is encoded in the genome of human.


name: A0A0G2JN01_HUMAN Killer cell immunoglobulin-like receptor, three Ig domains pseudogene 1 (trembl)


name: MB3LB_HUMAN Methyl-CpG-binding domain protein 3-like 2B (sprot)

description: A protein that is a translation product of the MBD3L2B gene in human.


name: tRNA-specific adenosine-34 deaminase activity

description: Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule.


D-tyrosyl-tRNA(Tyr) deacylase activity

description: Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA.


name: VAS1L_HUMAN V-type proton ATPase subunit S1-like protein (sprot)

description: A V-type proton ATPase subunit S1-like protein that is encoded in the genome of human.


site of polarized growth

description: Any part of a cell where non-isotropic growth takes place.


putrescine binding

description: Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.


name: LRRC2_HUMAN Leucine-rich repeat-containing protein 2 (sprot)

description: A leucine-rich repeat-containing protein 2 that is encoded in the genome of human.


name: ME15P_HUMAN Putative methyltransferase-like protein 15P1 (sprot)


name: peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

description: The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine.


name: double-strand break repair via break-induced replication

description: The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.


name: GOG8S_HUMAN Golgin subfamily A member 8S (sprot)

description: A protein that is a translation product of the GOLGA8S gene in human.


name: D19L4_HUMAN Probable C-mannosyltransferase DPY19L4 (sprot)

description: A protein dpy-19 4 that is encoded in the genome of human.


name: RGPD5_HUMAN RANBP2-like and GRIP domain-containing protein 5/6 (sprot)

description: A RANBP2-like and GRIP domain-containing protein 5/6 that is encoded in the genome of human.


name: MB3L5_HUMAN Putative methyl-CpG-binding domain protein 3-like 5 (sprot)


name: PAL4E_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4E (sprot)

description: A protein that is a translation product of the PPIAL4E gene in human.


DNA replication preinitiation complex

description: A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.


TSN19_HUMAN Tetraspanin-19 (sprot)

A protein that is a translation product of the TSPAN19 gene in human.


name: SMTL2_HUMAN Smoothelin-like protein 2 (sprot)

description: A smoothelin-like protein 2 that is encoded in the genome of human.


proteasome storage granule

description: An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state.


name: LRC63_HUMAN Leucine-rich repeat-containing protein 63 (sprot)

description: A leucine-rich repeat-containing protein 63 that is encoded in the genome of human.


name: GRTP1_HUMAN Growth hormone-regulated TBC protein 1 (sprot)

description: A growth hormone-regulated TBC protein 1 that is encoded in the genome of human.


monosaccharide transmembrane transport

description: The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.


name: rRNA acetylation involved in maturation of SSU-rRNA

description: Any rRNA acetylation that is involved in maturation of SSU-rRNA.


mitotic DNA replication initiation

description: Any DNA replication initiation involved in mitotic cell cycle DNA replication.


name: phagolysosome assembly involved in apoptotic cell clearance

description: The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance.


name: inositol tetrakisphosphate kinase activity

description: Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP.


name: A0A0G2JP03_HUMAN Killer cell immunoglobulin-like receptor 3DL3 (Fragment) (trembl)


Lsm1-7-Pat1 complex

description: A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway.


name: RGPD4_HUMAN RanBP2-like and GRIP domain-containing protein 4 (sprot)

description: A RanBP2-like and GRIP domain-containing protein 4 that is encoded in the genome of human.


N-terminal peptidyl-serine methylation

description: The methylation of the N-terminal serine of proteins.


name: DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates

description: Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA).


name: gonadotropin-releasing hormone receptor activity

description: Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.


name: regulation of translation at presynapse, modulating synaptic transmission

description: Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.


name: T11X2_HUMAN T-complex protein 11-like X-linked protein 2 (sprot)

description: A protein that is a translation product of the TCP11X2 gene in human.


vacuolar protein processing

description: Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes.


name: LRC58_HUMAN Leucine-rich repeat-containing protein 58 (sprot)

description: A leucine-rich repeat-containing protein 58 that is encoded in the genome of human.


short-chain carboxylesterase activity

description: Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms.


name: TBC12_HUMAN TBC1 domain family member 12 (sprot)

description: A TBC1 domain family member 12 that is encoded in the genome of human.


amino acid kinase activity

description: Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate.


siRNA 3'-end processing

description: The process of forming the mature 3' end of a siRNA molecule.


name: ARH37_HUMAN Rho guanine nucleotide exchange factor 37 (sprot)

description: A Rho guanine nucleotide exchange factor 37 that is encoded in the genome of human.


phosphorus-oxygen lyase activity

description: Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


post-mRNA release spliceosomal complex

description: A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac.


pyrimidine nucleoside transport

description: The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: positive regulation of G2/MI transition of meiotic cell cycle

description: Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle.


name: KHDCL_HUMAN Putative KHDC1-like protein (sprot)


name: RS10L_HUMAN Putative ribosomal protein eS10-like (sprot)


name: KI2LB_HUMAN Killer cell immunoglobulin-like receptor 2DL5B (sprot)

description: A killer cell immunoglobulin-like receptor 2DL5B that is encoded in the genome of human.


INY2B_HUMAN Protein INSYN2B (sprot)

A protein INSYN2B that is encoded in the genome of human.


SHSA8_HUMAN Protein shisa-8 (sprot)

A protein shisa-8 that is encoded in the genome of human.


name: PTG3L_HUMAN Putative protein PTGES3L (sprot)

description: A protein PTGES3L that is encoded in the genome of human.


glycine receptor clustering

description: The receptor clustering process in which glycine receptors are localized to distinct domains in the cell membrane.


name: biological process involved in interspecies interaction between organisms

description: Any process evolved to enable an interaction with an organism of a different species.


PRS48_HUMAN Serine protease 48 (sprot)

A serine protease 48 that is encoded in the genome of human.


KNCN_HUMAN Kinocilin (sprot)

A kinocilin that is encoded in the genome of human.


name: CTGEF_HUMAN cTAGE family member 15 (sprot)

description: A protein that is a translation product of the CTAGE15 gene in human.


name: A0A376A8Z9_HUMAN KIR2DS5 protein (trembl)


name: Pwp2p-containing subcomplex of 90S preribosome

description: A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p.


valine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.


exocyst localization

description: Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.


name: D-xylose 1-dehydrogenase (NADP+) activity

description: Catalysis of the reaction: D-xylose + NADP+ = D-xylono-1,5-lactone + H+ + NADPH.


SPA13_HUMAN Putative serpin A13 (sprot)

A putative serpin A13 that is encoded in the genome of human.


snRNA pseudouridine synthesis

description: The intramolecular conversion of uridine to pseudouridine in an snRNA molecule.


acetolactate synthase complex

description: A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate.


U4 snRNA 3'-end processing

description: Any process involved in forming the mature 3' end of a U4 snRNA molecule.


name: SPD15_HUMAN Putative speedy protein E15 (sprot)


name: GOG8J_HUMAN Golgin subfamily A member 8J (sprot)

description: A golgin subfamily A member 8J that is encoded in the genome of human.


name: SPD17_HUMAN Putative speedy protein E17 (sprot)


name: gonadotropin-releasing hormone receptor binding

description: Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.


name: NALF2_HUMAN NALCN channel auxiliary factor 2 (sprot)

description: A NALCN channel auxiliary factor 2 that is encoded in the genome of human.


name: QCR6L_HUMAN Cytochrome b-c1 complex subunit 6-like, mitochondrial (sprot)

description: A protein that is a translation product of the UQCRHL gene in human.


urotensin II receptor activity

description: Combining with urotensin II to initiate a change in cell activity.


name: S35G3_HUMAN Solute carrier family 35 member G3 (sprot)

description: A solute carrier family 35 member G3 that is encoded in the genome of human.


fructosamine metabolic process

description: The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.


name: LR14B_HUMAN Leucine-rich repeat-containing protein 14B (sprot)

description: A leucine-rich repeat-containing protein 14B that is encoded in the genome of human.


name: negative regulation of gastrin-induced gastric acid secretion

description: Any process that stops, prevents or reduces the frequency, rate or extent of gastrin-induced gastric acid secretion.


name: PRS29_HUMAN Putative serine protease 29 (sprot)


name: INT6L_HUMAN Integrator complex subunit 6-like (sprot)

description: An integrator complex subunit 6-like that is encoded in the genome of human.


transporter activity

description: Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.


cerebellar granular layer maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.


CAN13_HUMAN Calpain-13 (sprot)

A calpain-13 that is encoded in the genome of human.


name: nuclear polyadenylation-dependent snRNA catabolic process

description: The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA.


name: CPHXL_HUMAN Cytoplasmic polyadenylated homeobox-like protein (sprot)

description: A protein that is a translation product of the CPHXL gene in human.


soluble NSF attachment protein activity

description: Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex.


name: regulation of postsynaptic neurotransmitter receptor activity

description: Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector function such as ion selectivity or pore opening/closing in ionotropic receptors.


name: M1BL1_HUMAN Metallothionein 1H-like protein 1 (sprot)

description: A protein that is a translation product of the MT1HL1 gene in human.


name: RNA lariat debranching enzyme activator activity

description: Binds to and increases the activity of an RNA lariat debranching enzyme.


name: thiosulfate transmembrane transporter activity

description: Enables the transfer of thiosulfate ions, HS2O3(1-), from one side of a membrane to the other.


name: monounsaturated fatty acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of monounsaturated fatty acid.


ribose phosphate metabolic process

description: The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar.


lipoic acid binding

description: Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid.


name: nucleotide-excision repair factor 2 complex

description: One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p.


Atg8 activating enzyme activity

description: Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond.


spliceosomal tri-snRNP complex

description: A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP.


name: A0A0G2JLQ3_HUMAN Killer cell immunoglobulin-like receptor (trembl)


gluconokinase activity

description: Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+.


imidazolonepropionase activity

description: Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H2O = N-formimidoyl-L-glutamate + H+.


name: MAGC3_HUMAN Melanoma-associated antigen C3 (sprot)

description: A melanoma-associated antigen C3 that is encoded in the genome of human.


mitotic DNA damage checkpoint signaling

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A signal transduction process involved in mitotic DNA damage checkpoint.


name: ME3L1_HUMAN Putative homeobox protein Meis3-like 1 (sprot)


fatty-acyl-CoA synthase activity

description: Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.


name: CTGE8_HUMAN cTAGE family member 8 (sprot)

description: A cTAGE family member 8 that is encoded in the genome of human.


name: PYY3_HUMAN Putative peptide YY-3 (sprot)


name: CF052_HUMAN Putative uncharacterized protein C6orf52 (sprot)

description: A protein that is a translation product of the C6orf52 gene in human.


riboflavin binding

description: Binding to riboflavin.


name: MROH6_HUMAN Maestro heat-like repeat-containing protein family member 6 (sprot)

description: A protein that is a translation product of the MROH6 gene in human.


name: G protein-coupled glutamate receptor binding

description: Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor).


name: UAP1L_HUMAN UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 (sprot)

description: A UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 that is encoded in the genome of human.


description: Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.


name: LRC28_HUMAN Leucine-rich repeat-containing protein 28 (sprot)

description: A leucine-rich repeat-containing protein 28 that is encoded in the genome of human.


name: AG1L2_HUMAN Putative glycosyltransferase ALG1L2 (sprot)

description: A putative glycosyltransferase ALG1L2 that is encoded in the genome of human.


name: S36A3_HUMAN Proton-coupled amino acid transporter 3 (sprot)

description: A proton-coupled amino acid transporter 3 that is encoded in the genome of human.


name: CCYL3_HUMAN Putative cyclin-Y-like protein 3 (sprot)

description: A putative cyclin-Y-like protein 3 that is encoded in the genome of human.


name: nuclear polyadenylation-dependent snoRNA catabolic process

description: The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA.


tRNA wobble position uridine thiolation

description: The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.


guanine transport

description: The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: TLDC2_HUMAN TLD domain-containing protein 2 (sprot)

description: A TLD domain-containing protein 2 that is encoded in the genome of human.


U12 snRNA binding

description: Binding to a U12 small nuclear RNA (U12 snRNA).


name: SNUFL_HUMAN Putative SNURF-like protein (sprot)


name: SEML_HUMAN Putative protein SEM1, isoform 2 (sprot)


name: MSD1_HUMAN Myb/SANT-like DNA-binding domain-containing protein 1 (sprot)

description: A Myb/SANT-like DNA-binding domain-containing protein 1 that is encoded in the genome of human.


name: WF10A_HUMAN WAP four-disulfide core domain protein 10A (sprot)

description: A WAP four-disulfide core domain protein 10A that is encoded in the genome of human.


name: WDR5B_HUMAN WD repeat-containing protein 5B (sprot)

description: A WD repeat-containing protein 5B that is encoded in the genome of human.


name: ribose phosphate diphosphokinase complex

description: A protein complex having ribose phosphate diphosphokinase activity.


nucleophagy

description: A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded.


deoxyribonuclease I activity

description: Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products.


IgG receptor activity

description: Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: VSI10_HUMAN V-set and immunoglobulin domain-containing protein 10 (sprot)

description: A V-set and immunoglobulin domain-containing protein 10 that is encoded in the genome of human.


name: SATL1_HUMAN Spermidine/spermine N(1)-acetyltransferase-like protein 1 (sprot)

description: A spermidine/spermine N(1)-acetyltransferase-like protein 1 that is encoded in the genome of human.


spermidine binding

description: Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane.


HIR complex

description: A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p.


name: SCML1_HUMAN Sex comb on midleg-like protein 1 (sprot)

description: A sex comb on midleg-like protein 1 that is encoded in the genome of human.


name: glutathione-disulfide reductase (NADPH) activity

description: Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.


autophagy of peroxisome

description: The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions.


SEM6C_HUMAN Semaphorin-6C (sprot)

A semaphorin-6C that is encoded in the genome of human.


meiotic chromosome separation

description: The process in which chromosomes are physically detached from each other during meiosis.


name: MAGBG_HUMAN Melanoma-associated antigen B16 (sprot)

description: A melanoma-associated antigen B16 that is encoded in the genome of human.


behavior

description: The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.


description: The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


name: PMIS2_HUMAN Transmembrane protein PMIS2 (sprot)

description: A protein that is a translation product of the PMIS2 gene in human.


name: diadenosine pentaphosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of diadenosine pentaphosphate.


name: MCAF2_HUMAN Activating transcription factor 7-interacting protein 2 (sprot)

description: An activating transcription factor 7-interacting protein 2 that is encoded in the genome of human.


name: meiotic DNA double-strand break processing

description: The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis.


spine apparatus assembly

description: The aggregation, arrangement and bonding together of a set of components to form a spine apparatus.


response to 11-deoxycorticosterone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus.


name: A0A1W2PN81_HUMAN Neuronal acetylcholine receptor subunit alpha-7 (trembl)


regulation of muscle system process

description: Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.


name: plasma membrane signaling receptor complex

description: Any protein complex that is part of the plasma membrane and which functions as a signaling receptor.


neuromedin B receptor binding

description: Binding to a neuromedin B receptor.


F135B_HUMAN Protein FAM135B (sprot)

A protein FAM135B that is encoded in the genome of human.


name: plasmacytoid dendritic cell cytokine production

description: Any process that contributes to cytokine production by a plasmacytoid dendritic cell.


name: sodium-dependent multivitamin transmembrane transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate.


name: F220P_HUMAN Putative protein FAM220BP (sprot)


name: ARRD5_HUMAN Arrestin domain-containing protein 5 (sprot)

description: An arrestin domain-containing protein 5 that is encoded in the genome of human.


name: extrinsic component of postsynaptic early endosome membrane

description: The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


N-acetylglucosamine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.


name: regulation of skeletal muscle cell proliferation

description: Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation.


C2D2B_HUMAN Protein CC2D2B (sprot)

A protein CC2D2B that is encoded in the genome of human.


arginine catabolic process to ornithine

description: The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine.


protein methylesterase activity

description: Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol.


name: MROH1_HUMAN Maestro heat-like repeat-containing protein family member 1 (sprot)

description: A maestro heat-like repeat-containing protein family member 1 that is encoded in the genome of human.


name: phosphatidylinositol 3-kinase complex, class III, type II

description: A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p.


name: glycine biosynthetic process from serine

description: The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine.


description: Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid.


sulfite oxidase activity

description: Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate.


name: D19P2_HUMAN Putative C-mannosyltransferase DPY19L2P2 (sprot)

description: A protein dpy-19 2-like 2 that is encoded in the genome of human.


germ-line stem cell division

description: The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.


name: K1755_HUMAN Uncharacterized protein KIAA1755 (sprot)

description: An uncharacterized protein KIAA1755 that is encoded in the genome of human.


name: GOG8R_HUMAN Golgin subfamily A member 8R (sprot)

description: A protein that is a translation product of the GOLGA8R gene in human.


endoplasmic reticulum mannose trimming

description: Any protein alpha-1,2-demannosylation that takes place in the endoplasmic reticulum quality control compartment (ERQC).


name: ANR42_HUMAN Ankyrin repeat domain-containing protein 42 (sprot)

description: An ankyrin repeat domain-containing protein 42 that is encoded in the genome of human.


actin filament debranching

description: An actin filament severing process that results in the removal of actin filament branches specifically at the branch points.


name: SIRB2_HUMAN Signal-regulatory protein beta-2 (sprot)

description: A signal-regulatory protein beta-2 that is encoded in the genome of human.


description: Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.


name: regulation of protein localization to membrane

description: Any process that modulates the frequency, rate or extent of protein localization to membrane.


CCR4-NOT core complex

description: The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p.


name: TM88B_HUMAN Transmembrane protein 88B (sprot)

description: A transmembrane protein 88B that is encoded in the genome of human.


name: late endosome to vacuole transport via multivesicular body sorting pathway

description: The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole.


organic acid binding

description: Binding to an organic acid, any acidic compound containing carbon in covalent linkage.


name: CTGE9_HUMAN cTAGE family member 9 (sprot)

description: A cTAGE family member 9 that is encoded in the genome of human.


name: AN32C_HUMAN Putative uncharacterized protein ANP32CP (sprot)

description: A putative uncharacterized protein ANP32CP that is encoded in the genome of human.


UFM1 transferase activity

description: Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages.


name: MRO2A_HUMAN Maestro heat-like repeat-containing protein family member 2A (sprot)

description: A maestro heat-like repeat-containing protein family member 2A that is encoded in the genome of human.


name: SP201_HUMAN Transcription factor SPT20 homolog-like 1 (sprot)

description: A protein FAM48B1 that is encoded in the genome of human.


name: CHCH9_HUMAN Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial (sprot)


cytoplasmic U snRNP body

description: A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies.


name: RMXL2_HUMAN RNA-binding motif protein, X-linked-like-2 (sprot)

description: An RNA-binding motif protein, X-linked-like-2 that is encoded in the genome of human.


name: S35G6_HUMAN Solute carrier family 35 member G6 (sprot)

description: A solute carrier family 35 member G6 that is encoded in the genome of human.


name: DC8L1_HUMAN DDB1- and CUL4-associated factor 8-like protein 1 (sprot)

description: A DDB1- and CUL4-associated factor 8-like protein 1 that is encoded in the genome of human.


BH domain binding

description: Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains.


name: MEI1_HUMAN Meiosis inhibitor protein 1 (sprot)

description: A meiosis inhibitor protein 1 that is encoded in the genome of human.


name: P12L2_HUMAN POM121-like protein 2 (sprot)

description: A POM121-like protein 2 that is encoded in the genome of human.


name: DR4L1_HUMAN Putative dehydrogenase/reductase SDR family member 4-like 1 (sprot)


name: ANHX_HUMAN Anomalous homeobox protein (sprot)

description: An anomalous homeobox protein that is encoded in the genome of human.


nucleoside phosphate metabolic process

description: The chemical reactions and pathways involving any phosphorylated nucleoside.


name: SE1L2_HUMAN Protein sel-1 homolog 2 (sprot)

description: A protein sel-1 homolog 2 that is encoded in the genome of human.


name: OCEL1_HUMAN Occludin/ELL domain-containing protein 1 (sprot)

description: An occludin/ELL domain-containing protein 1 that is encoded in the genome of human.


name: mitochondrial proton-transporting ATP synthase, stator stalk

description: One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core.


name: ARH38_HUMAN Rho guanine nucleotide exchange factor 38 (sprot)

description: A Rho guanine nucleotide exchange factor 38 that is encoded in the genome of human.


S-formylglutathione hydrolase activity

description: Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+.


description: The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate.


name: diphosphoinositol polyphosphate metabolic process

description: The chemical reactions and pathways involving a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached.


septin ring

description: A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form.


name: RGPD2_HUMAN RANBP2-like and GRIP domain-containing protein 2 (sprot)

description: A RANBP2-like and GRIP domain-containing protein 2 that is encoded in the genome of human.


name: HEAT4_HUMAN HEAT repeat-containing protein 4 (sprot)

description: A HEAT repeat-containing protein 4 that is encoded in the genome of human.


name: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.


CCNJ_HUMAN Cyclin-J (sprot)

A cyclin-J that is encoded in the genome of human.


D-alanine transmembrane transport

description: The process in which D-alanine, the D-enantiomer of 2-aminopropanoic acid,  is transported across a lipid bilayer, from one side of a membrane to the other by means of some agent such as a transporter or pore.


name: MFS6L_HUMAN Major facilitator superfamily domain-containing protein 6-like (sprot)

description: A major facilitator superfamily domain-containing protein 6-like that is encoded in the genome of human.


spindle elongation

description: The cell cycle process in which the distance is lengthened between poles of the spindle.


perisynaptic extracellular matrix

description: The portion of the extracellular matrix that lies within the perisynaptic space.


name: KCNT1_HUMAN Potassium channel subfamily T member 1 (sprot)

description: A potassium channel subfamily T member 1 that is encoded in the genome of human.


name: TPBGL_HUMAN Trophoblast glycoprotein-like (sprot)

description: A trophoblast glycoprotein-like that is encoded in the genome of human.


name: T184C_HUMAN Transmembrane protein 184C (sprot)

description: A transmembrane protein 184C that is encoded in the genome of human.


XKR9_HUMAN XK-related protein 9 (sprot)

An XK-related protein 9 that is encoded in the genome of human.


secondary metabolic process

description: The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.


name: pyrimidine nucleobase biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.


UTP-C complex

description: A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p.


name: generation of catalytic spliceosome for second transesterification step

description: Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing.


SPA11_HUMAN Serpin A11 (sprot)

A serpin A11 that is encoded in the genome of human.


dystroglycan complex

description: A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.


nuclear pore central transport channel

description: The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153.


prostacyclin receptor activity

description: Combining with prostacyclin (PGI(2)) to initiate a change in cell activity.


name: structural constituent of postsynaptic intermediate filament cytoskeleton

description: The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton.


name: MDH1B_HUMAN Putative malate dehydrogenase 1B (sprot)

description: A putative malate dehydrogenase 1B that is encoded in the genome of human.


name: RGPD1_HUMAN RANBP2-like and GRIP domain-containing protein 1 (sprot)

description: A RANBP2-like and GRIP domain-containing protein 1 that is encoded in the genome of human.


name: T184B_HUMAN Transmembrane protein 184B (sprot)

description: A transmembrane protein 184B that is encoded in the genome of human.


name: TT39C_HUMAN Tetratricopeptide repeat protein 39C (sprot)

description: A tetratricopeptide repeat protein 39C that is encoded in the genome of human.


name: lysine biosynthetic process via aminoadipic acid

description: The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway.


name: SGE2P_HUMAN Putative SAGE1-like protein (sprot)


name: gonadotropin hormone-releasing hormone activity

description: The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary.


description: Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.


name: IT70A_HUMAN Intraflagellar transport protein 70A (sprot)

description: An intraflagellar transport protein 70A that is encoded in the genome of human.


propionate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid.


name: regulation of recycling endosome localization within postsynapse

description: Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse.


GTP cyclohydrolase binding

description: Binding to a GTP cyclohydrolase.


name: negative regulation of ribosome biogenesis

description: Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.


name: T178B_HUMAN Transmembrane protein 178B (sprot)

description: A transmembrane protein 178B that is encoded in the genome of human.


name: DJC25_HUMAN DnaJ homolog subfamily C member 25 (sprot)

description: A DnaJ homolog subfamily C member 25 that is encoded in the genome of human.


name: histone H3K79 methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group to the lysine residue at position 79 of the histone H3 protein.


name: GOG8N_HUMAN Golgin subfamily A member 8N (sprot)

description: A protein that is a translation product of the GOLGA8N gene in human.


name: GOG8K_HUMAN Golgin subfamily A member 8K (sprot)

description: A protein that is a translation product of the GOLGA8K gene in human.


name: type 1 melanin-concentrating hormone receptor binding

description: Binding to a type 1 melanin-concentrating hormone receptor.


name: DC122_HUMAN DDB1- and CUL4-associated factor 12-like protein 2 (sprot)

description: A DDB1- and CUL4-associated factor 12-like protein 2 that is encoded in the genome of human.


name: RRP7B_HUMAN Putative ribosomal RNA-processing protein 7 homolog B (sprot)


name: T11X1_HUMAN T-complex protein 11-like X-linked protein 1 (sprot)

description: A protein that is a translation product of the TCP11X1 gene in human.


name: PRS47_HUMAN Putative serine protease 47 (sprot)


name: SCML4_HUMAN Sex comb on midleg-like protein 4 (sprot)

description: A sex comb on midleg-like protein 4 that is encoded in the genome of human.


name: A0A126GWB0_HUMAN Olfactory receptor (trembl)


replication fork protection complex

description: A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.


name: nitrate transmembrane transporter activity

description: Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other.


name: fast-twitch skeletal muscle fiber contraction

description: A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability.


name: norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

description: A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change.


ubiquitin-like protein binding

description: Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein.


name: TBC26_HUMAN TBC1 domain family member 26 (sprot)

description: A TBC1 domain family member 26 that is encoded in the genome of human.


name: DC4L2_HUMAN DDB1- and CUL4-associated factor 4-like protein 2 (sprot)

description: A DDB1- and CUL4-associated factor 4-like protein 2 that is encoded in the genome of human.


name: A0A4W9AIG4_HUMAN Olfactory receptor (trembl)


beta-N-acetylglucosaminidase activity

description: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides.


name: PAL4D_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4D (sprot)

description: A protein that is a translation product of the PPIAL4D gene in human.


phagophore

description: A disk-like structure that expands, rounds up into a cup-shaped structure, and eventually closes around its cargo (for example cytoplasmic components) to become an autophagosome or Cvt vesicle.


regulation of ERBB signaling pathway

description: Any process that modulates the frequency, rate or extent of ERBB signaling pathway.


description: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.


polytene chromosome

description: A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.


PAS complex

description: A phosphatidylinositol kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKFYVE in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.


name: HNRC3_HUMAN Heterogeneous nuclear ribonucleoprotein C-like 3 (sprot)

description: A protein that is a translation product of the HNRNPCL3 gene in human.


name: negative regulation of G2/MI transition of meiotic cell cycle

description: Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle.


neuropeptide Y receptor binding

description: Binding to a neuropeptide Y receptor.


Swi5-Swi2 complex

description: A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching.


octopamine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species.


name: neurotransmitter receptor transport, postsynaptic endosome to lysosome

description: The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation.


P4R3C_HUMAN Protein PPP4R3C (sprot)

A protein that is a translation product of the PPP4R3C gene in human.


name: BTNLA_HUMAN Putative butyrophilin-like protein 10 pseudogene (sprot)


name: meiotic strand invasion involved in reciprocal meiotic recombination

description: The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.


name: negative regulation of serine-type peptidase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity.


peroxisomal importomer complex

description: A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners.


muscle attachment

description: The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).


O-glycan processing, core 1

description: The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-(1->3)-GalNAc.


name: establishment of cell polarity involved in ameboidal cell migration

description: The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell.


CURI complex

description: A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p.


description: The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary.


name: postsynaptic endocytic zone cytoplasmic component

description: The cytoplasmic component of the postsynaptic endocytic zone.


name: M4A10_HUMAN Membrane-spanning 4-domains subfamily A member 10 (sprot)

description: A membrane-spanning 4-domains subfamily A member 10 that is encoded in the genome of human.


name: RN3P2_HUMAN Putative RRN3-like protein RRN3P2 (sprot)


name: GOG8M_HUMAN Golgin subfamily A member 8M (sprot)

description: A protein that is a translation product of the GOLGA8M gene in human.


interleukin-8 production

description: The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


hydroxypyruvate isomerase activity

description: Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate.


name: CRCC2_HUMAN Ciliary rootlet coiled-coil protein 2 (sprot)

description: A ciliary rootlet coiled-coil protein 2 that is encoded in the genome of human.


name: K1614_HUMAN Uncharacterized protein KIAA1614 (sprot)

description: A protein that is a translation product of the KIAA1614 gene in human.


name: protein localization to kinetochore involved in kinetochore assembly

description: Any protein localization to kinetochore that is involved in kinetochore assembly.


name: GOG6D_HUMAN Golgin subfamily A member 6D (sprot)

description: A protein that is a translation product of the GOLGA6D gene in human.


name: CAST3_HUMAN Putative protein CASTOR3P (sprot)


detoxification of zinc ion

description: Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion.


pristanoyl-CoA oxidase activity

description: Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide.


intermediate filament-based process

description: Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins.


name: TEX26_HUMAN Testis-expressed protein 26 (sprot)

description: A testis-expressed protein 26 that is encoded in the genome of human.


name: GOG8I_HUMAN Putative golgin subfamily A member 8I (sprot)


name: FRYL_HUMAN Protein furry homolog-like (sprot)

description: A protein furry-like that is encoded in the genome of human.


GTP 3',8'-cyclase activity

description: Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.


name: DUX5_HUMAN Double homeobox protein 5 (sprot)

description: A double homeobox protein 5 that is encoded in the genome of human.


myosin II filament disassembly

description: The disassembly of a bipolar filament composed of myosin II molecules.


name: PAL4H_HUMAN Peptidyl-prolyl cis-trans isomerase A-like 4H (sprot)

description: A protein that is a translation product of the PPIAL4H gene in human.


RAVE complex

description: A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme.


name: nuclear mRNA surveillance of mRNA 3'-end processing

description: The set of processes involved in identifying and degrading mRNAs with incorrectly formed 3'-ends within the nucleus.


name: CEA21_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 21 (sprot)

description: A carcinoembryonic antigen-related cell adhesion molecule 21 that is encoded in the genome of human.


actin cortical patch localization

description: Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells.


name: IQCF5_HUMAN IQ domain-containing protein F5 (sprot)

description: An IQ domain-containing protein F5 that is encoded in the genome of human.


Seh1-associated complex

description: A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p.


GDP-mannose hydrolase activity

description: Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate.


name: cytoskeletal rearrangement involved in phagocytosis, engulfment

description: The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.


DNA recombinase complex

description: A protein-DNA complex consisting of a higher-order oligomer of strand exchange proteins (recombinases) on single-stranded DNA.


deoxyribonuclease II activity

description: Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products.


GRIFN_HUMAN Grifin (sprot)

A grifin that is encoded in the genome of human.


name: meiotic DNA integrity checkpoint signaling

description: A signal transduction process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during meiosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.


valyl-tRNA aminoacylation

description: The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


acetolactate synthase activity

description: Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.


chemokine production

description: The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.


name: PRS45_HUMAN Putative serine protease 45 (sprot)

description: A putative serine protease 45 that is encoded in the genome of human.


name: structural constituent of presynaptic active zone

description: The action of a molecule that contributes to the structural integrity of a presynaptic active zone.


name: LRC69_HUMAN Leucine-rich repeat-containing protein 69 (sprot)

description: A leucine-rich repeat-containing protein 69 that is encoded in the genome of human.


serine O-acyltransferase activity

description: Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule.


axonemal basal plate

description: Part of the axoneme consisting of a highly electron-dense region at the distal end of the ciliary transition zone within the axonemal lumen at which the axonemal central pair of microtubules is connected to the rest of the axonemal structure.


name: OLFL1_HUMAN Olfactomedin-like protein 1 (sprot)

description: An olfactomedin-like protein 1 that is encoded in the genome of human.


RNA polymerase II, holoenzyme

description: A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters.


D-lactate dehydrogenase activity

description: Catalysis of the reaction: (R)-lactate + NAD+ = H+ + NADH + pyruvate.


name: GOG6C_HUMAN Golgin subfamily A member 6C (sprot)

description: A protein that is a translation product of the GOLGA6C gene in human.


name: MF2L2_HUMAN Probable guanine nucleotide exchange factor MCF2L2 (sprot)

description: A probable guanine nucleotide exchange factor MCF2L2 that is encoded in the genome of human.


name: PDZ1P_HUMAN Putative PDZ domain-containing protein PDZK1P1 (sprot)


cupric reductase activity

description: Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH.


nuclear microtubule

description: Any microtubule in the nucleus of a cell.


bub1-bub3 complex

description: Protein complex that associates with the kinetochores.


name: regulation of regulatory ncRNA processing

description: Any process that modulates the frequency, rate or extent of regulatory non-coding RNA processing.


SERP3_HUMAN Serpin E3 (sprot)

A serpin E3 that is encoded in the genome of human.


description: Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A).


epinephrine secretion

description: The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system.


name: A0A087X1C1_HUMAN Thymosin beta 15C (trembl)


actin-based cell projection

description: A cell projection supported by an assembly of actin filaments, and which lacks microtubules.


name: neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

description: Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol.


name: folic acid-containing compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of folic acid and its derivatives.


telomere tethering at nuclear periphery

description: The process in which a telomere is maintained in a specific location at the nuclear periphery.


name: MRGRE_HUMAN Mas-related G-protein coupled receptor member E (sprot)

description: A Mas-related G-protein coupled receptor E that is encoded in the genome of human.


phosphocreatine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase.


Dbf4-dependent protein kinase complex

description: A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins.


U5 snRNA 3'-end processing

description: Any process involved in forming the mature 3' end of a U5 snRNA molecule.


name: slow-twitch skeletal muscle fiber contraction

description: A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue.


name: CC191_HUMAN Coiled-coil domain-containing protein 191 (sprot)

description: A protein that is a translation product of the CCDC191 gene in human.


recombinase activator activity

description: Binds to and increases the activity of a recombinase.


name: putrescine biosynthetic process from arginine, using agmatinase

description: The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step.


nuclear pre-replicative complex

description: A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.