tenascin complex

description: A extracellular matrix complex involved in cell adhesion and cell migration. Typically homotrimeric or homohexameric. In mammals, four complexes exist: Tenascin-C, Tenascin-N (also known as Tenascin-W), Tenascin-X and Tenascin-R.


CADH3_HUMAN Cadherin-3 (sprot)

A cadherin-3 that is encoded in the genome of human.


name: positive regulation of tyrosinase activity

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that activates or increases the activity of a tyrosinase enzyme monophenol oxygenase.


name: negative regulation of timing of catagen

description: Any process that stops, prevents, or reduces the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle.


name: positive regulation of melanosome transport

description: Any process that activates or increases the frequency, rate or extent of melanosome transport.


name: PUR6_HUMAN Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (sprot)

description: A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase that is encoded in the genome of human.


category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.


description: Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate.


name: 5-amino-4-imidazole carboxylate lyase activity

description: Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate.


purine nucleobase biosynthetic process

description: The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.


IL10_HUMAN Interleukin-10 (sprot)

An interleukin-10 that is encoded in the genome of human.


name: positive regulation of B cell apoptotic process

description: Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process.


interleukin-10 receptor binding

description: Binding to an interleukin-10 receptor.


name: negative regulation of chronic inflammatory response to antigenic stimulus

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.


name: negative regulation of myeloid dendritic cell activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.


name: negative regulation of interferon-alpha production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production.


name: negative regulation of interleukin-18 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production.


response to carbon monoxide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus.


name: negative regulation of cytokine activity

description: Any process that decreases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells.


name: negative regulation of chemokine (C-C motif) ligand 5 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5.


category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by interleukin-10 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


regulation of response to wounding

description: Any process that modulates the frequency, rate or extent of response to wounding.


ACES_HUMAN Acetylcholinesterase (sprot)

An acetylcholinesterase that is encoded in the genome of human.


name: acetylcholine catabolic process in synaptic cleft

description: The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission.


regulation of receptor recycling

description: Any process that modulates the frequency, rate, or extent of receptor recycling.


acetylcholine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline.


name: negative regulation of synaptic transmission, cholinergic

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.


IDS_HUMAN Iduronate 2-sulfatase (sprot)

An iduronate 2-sulfatase that is encoded in the genome of human.


iduronate-2-sulfatase activity

description: Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.


name: SCP2_HUMAN Sterol carrier protein 2 (sprot)

description: A sterol carrier protein 2 that is encoded in the genome of human.


description: Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA.


description: Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA.


name: positive regulation of intracellular cholesterol transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells.


lipid hydroperoxide transport

description: The directed movement of a lipid hydroperoxide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: UD11_HUMAN UDP-glucuronosyltransferase 1A1 (sprot)

description: A UDP-glucuronosyltransferase 1A1 that is encoded in the genome of human.


bilirubin conjugation

description: The chemical reactions and pathways resulting in the formation of bilirubin monoglucuronide or bilirubin diglucuronide, water-soluble derivatives of bilirubin.


name: negative regulation of steroid metabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.


biphenyl catabolic process

description: The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs).


cytochrome complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.


name: UD14_HUMAN UDP-glucuronosyltransferase 1A4 (sprot)

description: A UDP-glucuronosyltransferase 1A4 that is encoded in the genome of human.


name: UBA1_HUMAN Ubiquitin-like modifier-activating enzyme 1 (sprot)

description: A ubiquitin-like modifier-activating enzyme 1 that is encoded in the genome of human.


ubiquitin activating enzyme activity

description: Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.


name: GPX3_HUMAN Glutathione peroxidase 3 (sprot)

description: A glutathione peroxidase 3 that is encoded in the genome of human.


name: CCL1_HUMAN C-C motif chemokine 1 (sprot)

description: A C-C motif chemokine 1 that is encoded in the genome of human.


name: NDKB_HUMAN Nucleoside diphosphate kinase B (sprot)

description: A nucleoside diphosphate kinase B that is encoded in the genome of human.


protein histidine kinase activity

description: Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.


G-quadruplex DNA binding

description: Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome.


regulation of epidermis development

description: Any process that modulates the frequency, rate or extent of epidermis development.


name: ENPP1_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (sprot)

description: An ectonucleotide pyrophosphatase/phosphodiesterase family member 1 that is encoded in the genome of human.


exonuclease activity

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.


GTP diphosphatase activity

description: Catalysis of the reaction: GTP + H2O = GMP + H+ + diphosphate.


ATP diphosphatase activity

description: Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate.


description: Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.


cyclic-GMP-AMP hydrolase activity

description: Catalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP.


name: negative regulation of glycogen biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.


name: negative regulation of hh target transcription factor activity

description: Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling.


name: USF1_HUMAN Upstream stimulatory factor 1 (sprot)

description: An upstream stimulatory factor 1 that is encoded in the genome of human.


name: regulation of transcription from RNA polymerase II promoter by glucose

description: Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.


name: carbon catabolite regulation of transcription

description: A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources.


name: FGFR4_HUMAN Fibroblast growth factor receptor 4 (sprot)

description: A fibroblast growth factor receptor 4 that is encoded in the genome of human.


name: regulation of extracellular matrix disassembly

description: Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.


name: regulation of bile acid biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.


name: KCNA4_HUMAN Potassium voltage-gated channel subfamily A member 4 (sprot)

description: A voltage-gated potassium channel alpha subunit KCNA4 that is encoded in the genome of human.


name: KCNA5_HUMAN Potassium voltage-gated channel subfamily A member 5 (sprot)

description: A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of human.


name: voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization

description: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization

description: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: voltage-gated potassium channel activity involved in SA node cell action potential repolarization

description: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: membrane repolarization during bundle of His cell action potential

description: The process in which ions are transported across a membrane such that the bundle of His cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.


name: membrane repolarization during SA node cell action potential

description: The process in which an SA node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.


name: membrane repolarization during atrial cardiac muscle cell action potential

description: The process in which ions are transported across a membrane such that the atrial cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.


GALA_HUMAN Galanin peptides (sprot)

A galanin that is encoded in the genome of human.


type 1 galanin receptor binding

description: Binding to a type 1 galanin receptor.


type 2 galanin receptor binding

description: Binding to a type 2 galanin receptor.


type 3 galanin receptor binding

description: Binding to a type 3 galanin receptor.


name: regulation of glucocorticoid metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.


name: positive regulation of timing of catagen

description: Any process that activates or increases the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle.


H1T_HUMAN Histone H1t (sprot)

A histone H1t that is encoded in the genome of human.


SPR1B_HUMAN Cornifin-B (sprot)

A cornifin-B that is encoded in the genome of human.


name: SPR2E_HUMAN Small proline-rich protein 2E (sprot)

description: A small proline-rich protein 2E that is encoded in the genome of human.


name: SPR2D_HUMAN Small proline-rich protein 2D (sprot)

description: A small proline-rich protein 2D that is encoded in the genome of human.


name: HEM0_HUMAN 5-aminolevulinate synthase, erythroid-specific, mitochondrial (sprot)

description: A 5-aminolevulinate synthase, erythroid-specific, mitochondrial that is encoded in the genome of human.


name: ADRO_HUMAN NADPH:adrenodoxin oxidoreductase, mitochondrial (sprot)

description: An NADPH:adrenodoxin oxidoreductase, mitochondrial that is encoded in the genome of human.


ferredoxin-NADP+ reductase activity

description: Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+.


name: FGFR3_HUMAN Fibroblast growth factor receptor 3 (sprot)

description: A fibroblast growth factor receptor 3 that is encoded in the genome of human.


name: negative regulation of developmental growth

description: Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth.


name: KAPCG_HUMAN cAMP-dependent protein kinase catalytic subunit gamma (sprot)

description: A cAMP-dependent protein kinase catalytic subunit gamma that is encoded in the genome of human.


name: ROA2_HUMAN Heterogeneous nuclear ribonucleoproteins A2/B1 (sprot)

description: A heterogeneous nuclear ribonucleoproteins A2/B1 that is encoded in the genome of human.


single-stranded telomeric DNA binding

description: Binding to single-stranded telomere-associated DNA.


G-quadruplex DNA unwinding

description: The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'.


RNA transport

description: The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: positive regulation of telomere maintenance via telomere lengthening

description: Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening.


name: positive regulation of telomerase RNA reverse transcriptase activity

description: Any process that activates or increases the frequency, rate or extent of telomerase RNA reverse transcriptase activity.


miRNA transport

description: The directed movement of microRNA (miRNA) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.


name: RFX1_HUMAN MHC class II regulatory factor RFX1 (sprot)

description: An MHC class II regulatory factor RFX1 that is encoded in the genome of human.


CCNO_HUMAN Cyclin-O (sprot)

A cyclin-O that is encoded in the genome of human.


CALB2_HUMAN Calretinin (sprot)

A calretinin that is encoded in the genome of human.


CP7A1_HUMAN Cytochrome P450 7A1 (sprot)

A cytochrome P450 7A1 that is encoded in the genome of human.


description: Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O.


name: CBL_HUMAN E3 ubiquitin-protein ligase CBL (sprot)

description: An E3 ubiquitin-protein ligase CBL that is encoded in the genome of human.


name: regulation of Rap protein signal transduction

description: Any process that modulates the frequency, rate or extent of Rap protein signal transduction.


name: regulation of platelet-derived growth factor receptor-alpha signaling pathway

description: Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway.


name: IBP4_HUMAN Insulin-like growth factor-binding protein 4 (sprot)

description: An insulin-like growth factor-binding protein 4 that is encoded in the genome of human.


name: KAPCB_HUMAN cAMP-dependent protein kinase catalytic subunit beta (sprot)

description: A cAMP-dependent protein kinase catalytic subunit beta that is encoded in the genome of human.


name: QCR2_HUMAN Cytochrome b-c1 complex subunit 2, mitochondrial (sprot)

description: A cytochrome b-c1 complex subunit 2, mitochondrial that is encoded in the genome of human.


name: GTR5_HUMAN Solute carrier family 2, facilitated glucose transporter member 5 (sprot)

description: A solute carrier family 2, facilitated glucose transporter member 5 that is encoded in the genome of human.


name: regulation of systemic arterial blood pressure mediated by a chemical signal

description: The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine.


fructose import across plasma membrane

description: The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol.


name: TGM1_HUMAN Protein-glutamine gamma-glutamyltransferase K (sprot)

description: A protein-glutamine gamma-glutamyltransferase K that is encoded in the genome of human.


cell envelope organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present.


name: NR4A1_HUMAN Nuclear receptor subfamily 4immunitygroup A member 1 (sprot)

description: A nuclear receptor subfamily 4 immunity group A member 1 that is encoded in the genome of human.


name: neurotransmitter secretion involved in regulation of skeletal muscle contraction

description: The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.


name: cellular response to corticotropin-releasing hormone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response.


name: non-canonical inflammasome complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a non-canonical inflammasome complex.


CAH4_HUMAN Carbonic anhydrase 4 (sprot)

A carbonic anhydrase 4 that is encoded in the genome of human.


GNLY_HUMAN Granulysin (sprot)

A granulysin that is encoded in the genome of human.


name: AAAD_HUMAN Arylacetamide deacetylase (sprot)

description: An arylacetamide deacetylase that is encoded in the genome of human.


name: CPN2_HUMAN Carboxypeptidase N subunit 2 (sprot)

description: A carboxypeptidase N subunit 2 that is encoded in the genome of human.


EVI2A_HUMAN Protein EVI2A (sprot)

A protein EVI2A that is encoded in the genome of human.


name: HEMH_HUMAN Ferrochelatase, mitochondrial (sprot)

description: A ferrochelatase, mitochondrial that is encoded in the genome of human.


ferrochelatase activity

description: Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX.


detection of UV

description: The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.


name: regulation of eIF2 alpha phosphorylation by heme

description: Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a result of heme levels.


protoporphyrinogen IX metabolic process

description: The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation.


name: regulation of hemoglobin biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


name: LSHR_HUMAN Lutropin-choriogonadotropic hormone receptor (sprot)

description: A lutropin-choriogonadotropic hormone receptor that is encoded in the genome of human.


luteinizing hormone receptor activity

description: Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity.


name: choriogonadotropin hormone receptor activity

description: Combining with the choriogonadotropin hormone to initiate a change in cell activity.


choriogonadotropin hormone binding

description: Binding to choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit.


name: positive regulation of inositol trisphosphate biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.


name: development of secondary male sexual characteristics

description: The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion.


name: regulation of steroid hormone biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones.


name: PROZ_HUMAN Vitamin K-dependent protein Z (sprot)

description: A vitamin K-dependent protein Z that is encoded in the genome of human.


name: MMP8_HUMAN Neutrophil collagenase (sprot)

description: A neutrophil collagenase that is encoded in the genome of human.


name: MRC1_HUMAN Macrophage mannose receptor 1 (sprot)

description: A macrophage mannose receptor 1 that is encoded in the genome of human.


CRYGS_HUMAN Gamma-crystallin S (sprot)

A gamma-crystallin S that is encoded in the genome of human.


name: XPA_HUMAN DNA repair protein complementing XP-A cells (sprot)

description: A DNA repair protein complementing XP-A cells that is encoded in the genome of human.


name: HV102_HUMAN Immunoglobulin heavy variable 1-2 (sprot)

description: A protein that is a translation product of the IGHV1-2 gene in human.


AMPD1_HUMAN AMP deaminase 1 (sprot)

An AMP deaminase 1 that is encoded in the genome of human.


AMP deaminase activity

description: Catalysis of the reaction: AMP + H2O = IMP + NH3.


name: EST1_HUMAN Liver carboxylesterase 1 (sprot)

description: A liver carboxylesterase 1 that is encoded in the genome of human.


name: cholesterol ester hydrolysis involved in cholesterol transport

description: The cholesterol metabolic process in which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport.


regulation of bile acid secretion

description: Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.


FBLN1_HUMAN Fibulin-1 (sprot)

A fibulin-1 that is encoded in the genome of human.


name: TCEA1_HUMAN Transcription elongation factor A protein 1 (sprot)

description: A transcription elongation factor A protein 1 that is encoded in the genome of human.


name: PGH1_HUMAN Prostaglandin G/H synthase 1 (sprot)

description: A prostaglandin G/H synthase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.


ITA6_HUMAN Integrin alpha-6 (sprot)

An integrin alpha-6 that is encoded in the genome of human.


integrin alpha6-beta4 complex

description: An integrin complex that comprises one alpha6 subunit and one beta4 subunit.


name: SFPQ_HUMAN Splicing factor, proline- and glutamine-rich (sprot)

description: A splicing factor, proline- and glutamine-rich that is encoded in the genome of human.


name: TBG1_HUMAN Tubulin gamma-1 chain (sprot)

description: A tubulin gamma-1 chain that is encoded in the genome of human.


polar microtubule

description: Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart.


gamma-tubulin complex

description: A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species.


name: KELL_HUMAN Kell blood group glycoprotein (sprot)

description: A kell blood group glycoprotein that is encoded in the genome of human.


CAH6_HUMAN Carbonic anhydrase 6 (sprot)

A carbonic anhydrase 6 that is encoded in the genome of human.


name: PPIB_HUMAN Peptidyl-prolyl cis-trans isomerase B (sprot)

description: A eukaryotic peptidyl-prolyl cis-trans isomerase B that is encoded in the genome of human.


name: regulation of post-translational protein modification

description: Any process that modulates the frequency, rate or extent of post-translational protein modification.


S10A1_HUMAN Protein S100-A1 (sprot)

A protein S100-A1 that is encoded in the genome of human.


name: SRCH_HUMAN Sarcoplasmic reticulum histidine-rich calcium-binding protein (sprot)

description: A sarcoplasmic reticulum histidine-rich calcium-binding protein that is encoded in the genome of human.


name: regulation of peptidyl-serine phosphorylation

description: Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.


KALM_HUMAN Anosmin-1 (sprot)

An anosmin-1 that is encoded in the genome of human.


name: MAOM_HUMAN NAD-dependent malic enzyme, mitochondrial (sprot)

description: An NAD-dependent malic enzyme, mitochondrial that is encoded in the genome of human.


malic enzyme activity

description: Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.


name: malate dehydrogenase (decarboxylating) (NAD+) activity

description: Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+.


oxaloacetate decarboxylase activity

description: Catalysis of the reaction: oxaloacetate = pyruvate + CO2.


regulation of NADP metabolic process

description: Any process that modulates the frequency, rate or extent of NADP metabolic process.


name: GCSP_HUMAN Glycine dehydrogenase (decarboxylating), mitochondrial (sprot)

description: A glycine dehydrogenase (decarboxylating), mitochondrial that is encoded in the genome of human.


name: glycine dehydrogenase (decarboxylating) activity

description: Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2.


pyridoxal binding

description: Binding to pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6.


glycine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid.


response to methylamine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus.


response to lipoic acid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus.


name: SYWC_HUMAN Tryptophan--tRNA ligase, cytoplasmic (sprot)

description: A tryptophan--tRNA ligase, cytoplasmic that is encoded in the genome of human.


tryptophan-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).


tryptophanyl-tRNA aminoacylation

description: The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


name: RS3_HUMAN Small ribosomal subunit protein uS3 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS3 that is encoded in the genome of human.


oxidized pyrimidine DNA binding

description: Binding to a DNA region containing an oxidized pyrimidine residue.


small ribosomal subunit rRNA binding

description: Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA.


name: positive regulation of endodeoxyribonuclease activity

description: Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.


negative regulation of DNA repair

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.


response to TNF agonist

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a TNF agonist stimulus.


name: positive regulation of base-excision repair

description: Any process that activates or increases the frequency, rate or extent of base-excision repair.


NF-kappaB complex

description: A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression.


MYF6_HUMAN Myogenic factor 6 (sprot)

A myogenic factor 6 that is encoded in the genome of human.


name: GLRA1_HUMAN Glycine receptor subunit alpha-1 (sprot)

description: A glycine receptor subunit alpha-1 that is encoded in the genome of human.


taurine binding

description: Binding to taurine.


synaptic transmission, glycinergic

description: The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


righting reflex

description: A reflex process in which an animal immediately tries to turn over after being placed in a supine position.


name: GLRA2_HUMAN Glycine receptor subunit alpha-2 (sprot)

description: A glycine receptor subunit alpha-2 that is encoded in the genome of human.


name: GCSH_HUMAN Glycine cleavage system H protein, mitochondrial (sprot)

description: A glycine cleavage system H protein, mitochondrial that is encoded in the genome of human.


aminomethyltransferase activity

description: Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.


glycine cleavage complex

description: A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T.


CBLN1_HUMAN Cerebellin-1 (sprot)

A cerebellin-1 that is encoded in the genome of human.


name: negative regulation of inhibitory synapse assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory synapse assembly.


name: KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (sprot)

description: A ribosomal protein S6 kinase beta-1 that is encoded in the genome of human.


TOR signaling

description: The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.


response to L-leucine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-leucine stimulus.


name: JAK1_HUMAN Tyrosine-protein kinase JAK1 (sprot)

description: A tyrosine-protein kinase JAK1 that is encoded in the genome of human.


description: The series of molecular signals initiated by interleukin-9 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: PTPRB_HUMAN Receptor-type tyrosine-protein phosphatase beta (sprot)

description: A receptor-type tyrosine-protein phosphatase beta that is encoded in the genome of human.


name: PTPRD_HUMAN Receptor-type tyrosine-protein phosphatase delta (sprot)

description: A receptor-type tyrosine-protein phosphatase delta that is encoded in the genome of human.


name: trans-synaptic signaling by trans-synaptic complex

description: Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex.


name: PTPRE_HUMAN Receptor-type tyrosine-protein phosphatase epsilon (sprot)

description: A receptor-type tyrosine-protein phosphatase epsilon that is encoded in the genome of human.


name: PTPRG_HUMAN Receptor-type tyrosine-protein phosphatase gamma (sprot)

description: A receptor-type tyrosine-protein phosphatase gamma that is encoded in the genome of human.


name: PTPRZ_HUMAN Receptor-type tyrosine-protein phosphatase zeta (sprot)

description: A receptor-type tyrosine-protein phosphatase zeta that is encoded in the genome of human.


perineuronal net

description: A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain.


LORI_HUMAN Loricrin (sprot)

A loricrin that is encoded in the genome of human.


name: SP100_HUMAN Nuclear autoantigen Sp-100 (sprot)

description: A nuclear autoantigen Sp-100 that is encoded in the genome of human.


chromo shadow domain binding

description: Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.


maintenance of protein location

description: Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away.


regulation of Fas signaling pathway

description: Any process that modulates the frequency, rate or extent of Fas signaling pathway.


name: CRCM_HUMAN Colorectal mutant cancer protein (sprot)

description: A colorectal mutant cancer protein that is encoded in the genome of human.


name: TNFL4_HUMAN Tumor necrosis factor ligand superfamily member 4 (sprot)

description: A tumor necrosis factor ligand superfamily member 4 that is encoded in the genome of human.


name: positive regulation of immunoglobulin mediated immune response

description: Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.


memory T cell activation

description: The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


T-helper 2 cell activation

description: The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


response to nitrogen dioxide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus.


name: negative regulation of T-helper 1 cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation.


name: positive regulation of CD4-positive, alpha-beta T cell costimulation

description: Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation.


name: positive regulation of interleukin-4-dependent isotype switching to IgE isotypes

description: Any process that activates or increases the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes.


name: NFYA_HUMAN Nuclear transcription factor Y subunit alpha (sprot)

description: A nuclear transcription factor Y subunit alpha that is encoded in the genome of human.


CCAAT-binding factor complex

description: A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5.


name: OMGP_HUMAN Oligodendrocyte-myelin glycoprotein (sprot)

description: An oligodendrocyte-myelin glycoprotein that is encoded in the genome of human.


An adenosylhomocysteinase that is encoded in the genome of human.


adenosylhomocysteinase activity

description: Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.


name: H2B1O_HUMAN Histone H2B type 1-O (sprot)

description: A histone H2B type 1-O that is encoded in the genome of human.


COF1_HUMAN Cofilin-1 (sprot)

A cofilin-1 that is encoded in the genome of human.


name: BDNF_HUMAN Brain-derived neurotrophic factor (sprot)

description: A brain-derived neurotrophic factor that is encoded in the genome of human.


name: brain-derived neurotrophic factor receptor signaling pathway

description: The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands.


name: positive regulation of collateral sprouting

description: Any process that activates or increases the frequency, rate or extent of collateral sprouting.


name: ANFC_HUMAN C-type natriuretic peptide (sprot)

description: A C-type natriuretic peptide that is encoded in the genome of human.


name: IF4B_HUMAN Eukaryotic translation initiation factor 4B (sprot)

description: A eukaryotic translation initiation factor 4B that is encoded in the genome of human.


name: HAP40_HUMAN 40-kDa huntingtin-associated protein (sprot)

description: A 40-kDa huntingtin-associated protein that is encoded in the genome of human.


vesicle cytoskeletal trafficking

description: The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins.


name: AT2B4_HUMAN Plasma membrane calcium-transporting ATPase 4 (sprot)

description: A plasma membrane calcium-transporting ATPase 4 that is encoded in the genome of human.


name: nitric-oxide synthase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of nitric oxide synthase.


name: urinary bladder smooth muscle contraction

description: A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract.


name: negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor protein signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands.


name: negative regulation of the force of heart contraction

description: Any process that decreases the force of heart muscle contraction.


name: negative regulation of arginine catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of arginine catabolic process.


calcium ion export

description: The directed movement of calcium ion out of a cell or organelle.


name: regulation of sodium ion transmembrane transport

description: Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport.


name: negative regulation of cellular response to vascular endothelial growth factor stimulus

description: Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus.


name: negative regulation of citrulline biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of citrulline biosynthetic process.


name: IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (sprot)

description: An inositol-trisphosphate 3-kinase A that is encoded in the genome of human.


name: calmodulin-dependent protein kinase activity

description: Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.


description: Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+.


name: DGKA_HUMAN Diacylglycerol kinase alpha (sprot)

description: A diacylglycerol kinase alpha that is encoded in the genome of human.


alkylglycerol kinase activity

description: Catalysis of the reaction: 1-alkyl-sn-glycerol + ATP = 1-alkyl-sn-glycerol 3-phosphate + ADP + 2 H+.


name: PAX7_HUMAN Paired box protein Pax-7 (sprot)

description: A paired box protein Pax-7 that is encoded in the genome of human.


name: PAX3_HUMAN Paired box protein Pax-3 (sprot)

description: A paired box protein Pax-3 that is encoded in the genome of human.


name: VAMP1_HUMAN Vesicle-associated membrane protein 1 (sprot)

description: A vesicle-associated membrane protein 1 that is encoded in the genome of human.


name: GATA2_HUMAN Endothelial transcription factor GATA-2 (sprot)

description: An endothelial transcription factor GATA-2 that is encoded in the genome of human.


name: ventral spinal cord interneuron differentiation

description: The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate.


cell differentiation in hindbrain

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.


name: commitment of neuronal cell to specific neuron type in forebrain

description: The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain.


semicircular canal development

description: The progression of the semicircular canal from its initial formation to the mature structure.


name: negative regulation of brown fat cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of brown fat cell differentiation.


name: regulation of forebrain neuron differentiation

description: Any process that modulates the frequency, rate or extent of forebrain neuron differentiation.


name: GATA3_HUMAN Trans-acting T-cell-specific transcription factor GATA-3 (sprot)

description: A trans-acting T-cell-specific transcription factor GATA-3 that is encoded in the genome of human.


interleukin-2 receptor binding

description: Binding to an interleukin-2 receptor.


name: negative regulation of mammary gland epithelial cell proliferation

description: Any process that stops, prevents or reduces the rate or extent of mammary gland epithelial cell proliferation.


parathyroid hormone secretion

description: The regulated release of parathyroid hormone into the circulatory system.


thymic T cell selection

description: The process of T cell selection that occurs in the thymus.


name: positive regulation of ureteric bud formation

description: Any process that increases the rate or extent of the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct.


nephric duct morphogenesis

description: The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney.


name: regulation of nephron tubule epithelial cell differentiation

description: Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation.


name: negative regulation of cell proliferation involved in mesonephros development

description: Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in mesonephros development.


name: regulation of cellular response to X-ray

description: Any process that modulates the frequency, rate or extent of cellular response to X-ray.


name: negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation

description: Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation.


name: negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation

description: Any process that stops, prevents or reduces the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation.


name: CPT2_HUMAN Carnitine O-palmitoyltransferase 2, mitochondrial (sprot)

description: A carnitine O-palmitoyltransferase 2, mitochondrial that is encoded in the genome of human.


description: Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.


description: Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA.


carnitine metabolic process

description: The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.


KTHY_HUMAN Thymidylate kinase (sprot)

A thymidylate kinase that is encoded in the genome of human.


thymidylate kinase activity

description: Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.


dTDP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate).


name: RIR1_HUMAN Ribonucleoside-diphosphate reductase large subunit (sprot)

description: A ribonucleoside-diphosphate reductase large subunit that is encoded in the genome of human.


name: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

description: Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.


description: Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor.


mitochondrial DNA replication

description: The process in which new strands of DNA are synthesized in the mitochondrion.


name: ribonucleoside diphosphate metabolic process

description: The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar.


description: The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


description: The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


description: An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor.


PRPH2_HUMAN Peripherin-2 (sprot)

A peripherin-2 that is encoded in the genome of human.


name: response to low light intensity stimulus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2.


name: FSHR_HUMAN Follicle-stimulating hormone receptor (sprot)

description: A follitropin receptor that is encoded in the genome of human.


name: follicle-stimulating hormone receptor activity

description: Combining with follicle-stimulating hormone to initiate a change in cell activity.


CMA1_HUMAN Chymase (sprot)

A chymase that is encoded in the genome of human.


name: SC6A2_HUMAN Sodium-dependent noradrenaline transporter (sprot)

description: A sodium-dependent noradrenaline transporter that is encoded in the genome of human.


description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in).


IL32_HUMAN Interleukin-32 (sprot)

An interleukin-32 that is encoded in the genome of human.


name: LAMA2_HUMAN Laminin subunit alpha-2 (sprot)

description: A laminin subunit alpha-2 that is encoded in the genome of human.


name: positive regulation of synaptic transmission, cholinergic

description: Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.


name: GBRR1_HUMAN Gamma-aminobutyric acid receptor subunit rho-1 (sprot)

description: A gamma-aminobutyric acid receptor subunit rho-1 that is encoded in the genome of human.


name: FCAR_HUMAN Immunoglobulin alpha Fc receptor (sprot)

description: An immunoglobulin alpha Fc receptor that is encoded in the genome of human.


PRTN3_HUMAN Myeloblastin (sprot)

A myeloblastin that is encoded in the genome of human.


name: ZBT25_HUMAN Zinc finger and BTB domain-containing protein 25 (sprot)

description: A zinc finger and BTB domain-containing protein 25 that is encoded in the genome of human.


name: ALAT1_HUMAN Alanine aminotransferase 1 (sprot)

description: An alanine aminotransferase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.


name: CX7A1_HUMAN Cytochrome c oxidase subunit 7A1, mitochondrial (sprot)

description: A cytochrome c oxidase subunit 7A1, mitochondrial that is encoded in the genome of human.


name: COX7B_HUMAN Cytochrome c oxidase subunit 7B, mitochondrial (sprot)

description: A cytochrome c oxidase subunit 7B, mitochondrial that is encoded in the genome of human.


MMP11_HUMAN Stromelysin-3 (sprot)

A stromelysin-3 that is encoded in the genome of human.


name: CCND1_HUMAN G1/S-specific cyclin-D1 (sprot)

description: A G1/S-specific cyclin-D1 that is encoded in the genome of human.


re-entry into mitotic cell cycle

description: The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state.


name: positive regulation of mammary gland epithelial cell proliferation

description: Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation.


cyclin D1-CDK6 complex

description: A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


name: RAE1_HUMAN Rab proteins geranylgeranyltransferase component A 1 (sprot)

description: A Rab proteins geranylgeranyltransferase component A 1 that is encoded in the genome of human.


Rab geranylgeranyltransferase activity

description: Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.


protein geranylgeranylation

description: The covalent attachment of a geranylgeranyl group to a protein.


description: An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein).


name: CRHBP_HUMAN Corticotropin-releasing factor-binding protein (sprot)

description: A corticotropin-releasing factor-binding protein that is encoded in the genome of human.


corticotropin-releasing hormone binding

description: Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland.


regulation of corticotropin secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell.


name: negative regulation of corticotropin secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell.


name: cellular response to gonadotropin-releasing hormone

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.


name: negative regulation of corticotropin-releasing hormone receptor activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of corticotropin-releasing hormone receptor activity.


secondary lysosome

description: Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome.


name: ERD21_HUMAN ER lumen protein-retaining receptor 1 (sprot)

description: An ER lumen protein-retaining receptor 1 that is encoded in the genome of human.


name: IL4RA_HUMAN Interleukin-4 receptor subunit alpha (sprot)

description: An interleukin-4 receptor subunit alpha that is encoded in the genome of human.


interleukin-4 receptor activity

description: Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


CP3A7_HUMAN Cytochrome P450 3A7 (sprot)

A cytochrome P450 3A7 that is encoded in the genome of human.


name: COT2_HUMAN COUP transcription factor 2 (sprot)

description: A COUP transcription factor 2 that is encoded in the genome of human.


radial pattern formation

description: The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur.


name: lymphatic endothelial cell fate commitment

description: The commitment of a venous blood vessel endothelial cell to a lymphatic endothelial cell fate and its capacity to differentiate into a lymphatic endothelial cell.


name: GA45A_HUMAN Growth arrest and DNA damage-inducible protein GADD45 alpha (sprot)

description: A growth arrest and DNA damage-inducible protein GADD45 alpha that is encoded in the genome of human.


name: negative regulation of peptidyl-serine phosphorylation of STAT protein

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


name: EDNRB_HUMAN Endothelin receptor type B (sprot)

description: An endothelin receptor type B that is encoded in the genome of human.


heparin metabolic process

description: The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.


aldosterone metabolic process

description: The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance.


name: enteric smooth muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine.


response to endothelin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3).


name: EF1B_HUMAN Elongation factor 1-beta (sprot)

description: An elongation factor 1-beta that is encoded in the genome of human.


name: eukaryotic translation elongation factor 1 complex

description: A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma.


name: AT5F1_HUMAN ATP synthase F(0) complex subunit B1, mitochondrial (sprot)

description: An ATP synthase F(0) complex subunit B1, mitochondrial that is encoded in the genome of human.


name: THAS_HUMAN Thromboxane-A synthase (sprot)

description: A thromboxane-A synthase that is encoded in the genome of human.


thromboxane-A synthase activity

description: Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2).


name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

description: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.


name: 12-hydroxyheptadecatrienoic acid synthase activity

description: Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA).


icosanoid metabolic process

description: The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids.


name: AKAP5_HUMAN A-kinase anchor protein 5 (sprot)

description: An A-kinase anchor protein 5 that is encoded in the genome of human.


name: positive regulation of endosome to plasma membrane protein transport

description: Any process that activates or increases the frequency, rate or extent of endosome to plasma membrane protein transport.


postsynaptic recycling endosome

description: A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signaling and so can play a role in long term potentiation.


name: IBP6_HUMAN Insulin-like growth factor-binding protein 6 (sprot)

description: An insulin-like growth factor-binding protein 6 that is encoded in the genome of human.


name: insulin-like growth factor binary complex

description: A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development.


name: IBP5_HUMAN Insulin-like growth factor-binding protein 5 (sprot)

description: An insulin-like growth factor-binding protein 5 that is encoded in the genome of human.


name: negative regulation of muscle tissue development

description: Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development.


name: negative regulation of skeletal muscle hypertrophy

description: Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy.


name: PPAC_HUMAN Low molecular weight phosphotyrosine protein phosphatase (sprot)

description: A low molecular weight phosphotyrosine protein phosphatase that is encoded in the genome of human.


name: non-membrane spanning protein tyrosine phosphatase activity

description: Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.


name: KPCL_HUMAN Protein kinase C eta type (sprot)

description: A protein kinase C eta type that is encoded in the genome of human.


name: diacylglycerol-dependent, calcium-independent serine/threonine kinase activity

description: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium.


name: THIL_HUMAN Acetyl-CoA acetyltransferase, mitochondrial (sprot)

description: An acetyl-CoA acetyltransferase, mitochondrial that is encoded in the genome of human.


C-acetyltransferase activity

description: Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule.


ketone body catabolic process

description: The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA.


name: metanephric proximal convoluted tubule development

description: The process whose specific outcome is the progression of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule.


ketone body metabolic process

description: The chemical reactions and pathways involving ketone body.


propionyl-CoA biosynthetic process

description: The chemical reactions and pathways resulting in the formation of propionyl-CoA.


TENA_HUMAN Tenascin (sprot)

A tenascin that is encoded in the genome of human.


name: mesenchymal-epithelial cell signaling involved in prostate gland development

description: Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted contributing to the progression of the prostate gland over time.


name: cellular response to prostaglandin D stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus.


name: MYL9_HUMAN Myosin regulatory light polypeptide 9 (sprot)

description: A myosin regulatory light polypeptide 9 that is encoded in the genome of human.


DNAS1_HUMAN Deoxyribonuclease-1 (sprot)

A deoxyribonuclease-1 that is encoded in the genome of human.


name: neutrophil activation involved in immune response

description: The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


name: regulation of neutrophil mediated cytotoxicity

description: Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil.


CCNC_HUMAN Cyclin-C (sprot)

A cyclin-C that is encoded in the genome of human.


G0 to G1 transition

description: The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression.


CKM complex

description: Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8.


name: CCNE1_HUMAN G1/S-specific cyclin-E1 (sprot)

description: A G1/S-specific cyclin-E1 that is encoded in the genome of human.


cyclin E1-CDK2 complex

description: A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


CP2F1_HUMAN Cytochrome P450 2F1 (sprot)

A cytochrome P450 2F1 that is encoded in the genome of human.


naphthalene catabolic process

description: The chemical reactions and pathways resulting in the breakdown of naphthalene.


name: RPB1_HUMAN DNA-directed RNA polymerase II subunit RPB1 (sprot)

description: A DNA-directed RNA polymerase II subunit RPB1 that is encoded in the genome of human.


microfibril binding

description: Binding to a microfibril, any small fibril occurring in biological material.


name: CDK2_HUMAN Cyclin-dependent kinase 2 (sprot)

description: A cyclin-dependent kinase 2 that is encoded in the genome of human.


name: positive regulation of DNA-templated DNA replication initiation

description: Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication.


name: regulation of anaphase-promoting complex-dependent catabolic process

description: Any process that modulates the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.


cyclin A1-CDK2 complex

description: A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


name: HRH2_HUMAN Histamine H2 receptor (sprot)

description: A histamine H2 receptor that is encoded in the genome of human.


histamine receptor activity

description: Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.


name: CXCR1_HUMAN C-X-C chemokine receptor type 1 (sprot)

description: A C-X-C chemokine receptor type 1 that is encoded in the genome of human.


interleukin-8 receptor activity

description: Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


description: The series of molecular signals initiated by interleukin-8 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: CXCR2_HUMAN C-X-C chemokine receptor type 2 (sprot)

description: A C-X-C chemokine receptor type 2 that is encoded in the genome of human.


name: APC_HUMAN Adenomatous polyposis coli protein (sprot)

description: An adenomatous polyposis coli protein that is encoded in the genome of human.


name: regulation of microtubule-based movement

description: Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.


name: positive regulation of protein localization to centrosome

description: Any process that activates or increases the frequency, rate or extent of protein localization to centrosome.


name: CD24_HUMAN Signal transducer CD24 (sprot)

description: A signal transducer CD24 that is encoded in the genome of human.


name: B cell receptor transport into membrane raft

description: The directed movement of a B cell receptor into a membrane raft.


name: chemokine receptor transport out of membrane raft

description: The directed movement of a chemokine receptor out of a membrane raft.


name: negative regulation of transforming growth factor beta3 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3.


name: CO8A2_HUMAN Collagen alpha-2(VIII) chain (sprot)

description: A collagen alpha-2(VIII) chain that is encoded in the genome of human.


name: FPR3_HUMAN N-formyl peptide receptor 3 (sprot)

description: An N-formyl peptide receptor 3 that is encoded in the genome of human.


name: FPR2_HUMAN N-formyl peptide receptor 2 (sprot)

description: An N-formyl peptide receptor 2 that is encoded in the genome of human.


GUC2C_HUMAN Guanylyl cyclase C (sprot)

A guanylyl cyclase C that is encoded in the genome of human.


name: ARBK1_HUMAN Beta-adrenergic receptor kinase 1 (sprot)

description: A beta-adrenergic receptor kinase 1 that is encoded in the genome of human.


name: G protein-coupled receptor kinase activity

description: Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate.


name: beta-adrenergic receptor kinase activity

description: Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor.


name: desensitization of G protein-coupled receptor signaling pathway

description: The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.


name: negative regulation of the force of heart contraction by chemical signal

description: Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.


name: positive regulation of catecholamine secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine.


name: negative regulation of striated muscle contraction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.


name: negative regulation of relaxation of smooth muscle

description: Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of smooth muscle.


name: ADA1D_HUMAN Alpha-1D adrenergic receptor (sprot)

description: An alpha-1D adrenergic receptor that is encoded in the genome of human.


name: EDNRA_HUMAN Endothelin-1 receptor (sprot)

description: An endothelin-1 receptor that is encoded in the genome of human.


cardiac chamber formation

description: The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.


name: left ventricular cardiac muscle tissue morphogenesis

description: The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized.


name: regulation of protein localization to cell leading edge

description: Any process that modulates the frequency, rate or extent of protein localization to cell leading edge.


NK1R_HUMAN Substance-P receptor (sprot)

A substance-P receptor that is encoded in the genome of human.


substance P receptor activity

description: Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity.


angiotensin-mediated drinking behavior

description: The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst.


name: smooth muscle contraction involved in micturition

description: The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body.


name: PTAFR_HUMAN Platelet-activating factor receptor (sprot)

description: A mammalian-type platelet-activating factor receptor that is encoded in the genome of human.


cellular response to gravity

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus.


positive regulation of transcytosis

description: Any process that activates or increases the frequency, rate or extent of transcytosis.


name: positive regulation of maternal process involved in parturition

description: Any process that activates or increases the frequency, rate or extent of maternal process involved in parturition.


name: positive regulation of gastro-intestinal system smooth muscle contraction

description: Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.


name: cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus.


name: ACKR3_HUMAN Atypical chemokine receptor 3 (sprot)

description: An atypical chemokine receptor 3 that is encoded in the genome of human.


oculomotor nerve development

description: The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.


name: PAR1_HUMAN Proteinase-activated receptor 1 (sprot)

description: A proteinase-activated receptor 1 that is encoded in the genome of human.


name: negative regulation of glomerular filtration

description: Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process whereby blood is filtered by the glomerulus into the renal tubule.


name: establishment of synaptic specificity at neuromuscular junction

description: The biological process in which a synapse between a motor neuron and a muscle is initially formed.


dendritic cell homeostasis

description: The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.


name: negative regulation of renin secretion into blood stream

description: Any process that stops, prevents or reduces the frequency, rate or extent of renin secretion into blood stream.


MYP0_HUMAN Myelin protein P0 (sprot)

A myelin P0 protein that is encoded in the genome of human.


cell aggregation

description: The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation.


name: MCM3_HUMAN DNA replication licensing factor MCM3 (sprot)

description: A DNA replication licensing factor MCM3 that is encoded in the genome of human.


MCM complex

description: A hexameric protein complex required for the initiation and regulation of DNA replication.


name: NFYB_HUMAN Nuclear transcription factor Y subunit beta (sprot)

description: A nuclear transcription factor Y subunit beta that is encoded in the genome of human.


A zinc-alpha-2-glycoprotein that is encoded in the genome of human.


name: THTM_HUMAN 3-mercaptopyruvate sulfurtransferase (sprot)

description: A 3-mercaptopyruvate sulfurtransferase that is encoded in the genome of human.


description: Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate.


sulfur amino acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.


cyanate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid.


hydrogen sulfide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S.


name: LAMA1_HUMAN Laminin subunit alpha-1 (sprot)

description: A laminin subunit alpha-1 that is encoded in the genome of human.


laminin-3 complex

description: A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains.


name: RS12_HUMAN Small ribosomal subunit protein eS12 (sprot)

description: A small ribosomal subunit protein eS12 that is encoded in the genome of human.


name: BRD2_HUMAN Bromodomain-containing protein 2 (sprot)

description: A bromodomain-containing protein 2 that is encoded in the genome of human.


acetylation-dependent protein binding

description: Binding to a protein upon acetylation of the target protein.


name: TNR6_HUMAN Tumor necrosis factor receptor superfamily member 6 (sprot)

description: A tumor necrosis factor receptor superfamily member 6 that is encoded in the genome of human.


Fas signaling pathway

description: The series of molecular signals initiated by the binding of a ligand to a Fas receptor on the surface of the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily.


name: TYY1_HUMAN Transcriptional repressor protein YY1 (sprot)

description: A transcriptional repressor protein YY1 that is encoded in the genome of human.


name: DNJB1_HUMAN DnaJ homolog subfamily B member 1 (sprot)

description: A DnaJ homolog subfamily B member 1 that is encoded in the genome of human.


name: DNJB2_HUMAN DnaJ homolog subfamily B member 2 (sprot)

description: A DnaJ homolog subfamily B member 2 that is encoded in the genome of human.


name: regulation of chaperone-mediated protein folding

description: Any process that modulates the frequency, rate or extent of chaperone-mediated protein folding.


name: ATPA_HUMAN ATP synthase subunit alpha, mitochondrial (sprot)

description: An ATP synthase subunit alpha, mitochondrial that is encoded in the genome of human.


MT3_HUMAN Metallothionein-3 (sprot)

A metallothionein-3 that is encoded in the genome of human.


zinc ion transport

description: The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: intracellular monoatomic cation homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom.


leptin-mediated signaling pathway

description: The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.


CATS_HUMAN Cathepsin S (sprot)

A cathepsin S that is encoded in the genome of human.


name: PSA1_HUMAN Proteasome subunit alpha type-1 (sprot)

description: A proteasome subunit alpha type-1 that is encoded in the genome of human.


name: PSA2_HUMAN Proteasome subunit alpha type-2 (sprot)

description: A proteasome subunit alpha type-2 that is encoded in the genome of human.


name: PSA3_HUMAN Proteasome subunit alpha type-3 (sprot)

description: A proteasome subunit alpha type-3 that is encoded in the genome of human.


name: PSA4_HUMAN Proteasome subunit alpha type-4 (sprot)

description: A proteasome subunit alpha type-4 that is encoded in the genome of human.


RBTN2_HUMAN Rhombotin-2 (sprot)

A rhombotin-2 that is encoded in the genome of human.


RBTN1_HUMAN Rhombotin-1 (sprot)

A rhombotin-1 that is encoded in the genome of human.


S100P_HUMAN Protein S100-P (sprot)

A protein S100-P that is encoded in the genome of human.


name: UCP1_HUMAN Mitochondrial brown fat uncoupling protein 1 (sprot)

description: A mitochondrial brown fat uncoupling protein 1 that is encoded in the genome of human.


purine ribonucleotide binding

description: Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.


name: cellular response to dehydroepiandrosterone

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus.


name: NPY1R_HUMAN Neuropeptide Y receptor type 1 (sprot)

description: A neuropeptide Y receptor type 1 that is encoded in the genome of human.


peptide YY receptor activity

description: Combining with gut peptide YY to initiate a change in cell activity.


name: pancreatic polypeptide receptor activity

description: Combining with pancreatic polypeptide PP to initiate a change in cell activity.


neuropeptide Y receptor activity

description: Combining with neuropeptide Y to initiate a change in cell activity.


name: CO5A3_HUMAN Collagen alpha-3(V) chain (sprot)

description: A collagen alpha-3(V) chain that is encoded in the genome of human.


name: TNR5_HUMAN Tumor necrosis factor receptor superfamily member 5 (sprot)

description: A tumor necrosis factor receptor superfamily member 5 that is encoded in the genome of human.


B cell mediated immunity

description: Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.


name: IKBA_HUMAN NF-kappa-B inhibitor alpha (sprot)

description: An NF-kappa-B inhibitor alpha that is encoded in the genome of human.


nuclear localization sequence binding

description: Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.


ITA3_HUMAN Integrin alpha-3 (sprot)

An integrin alpha-3 that is encoded in the genome of human.


regulation of BMP signaling pathway

description: Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.


growth cone filopodium

description: A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone.


ITB7_HUMAN Integrin beta-7 (sprot)

An integrin beta-7 that is encoded in the genome of human.


ITB8_HUMAN Integrin beta-8 (sprot)

An integrin beta-8 that is encoded in the genome of human.


ganglioside metabolic process

description: The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.


name: PTX3_HUMAN Pentraxin-related protein PTX3 (sprot)

description: A pentraxin-related protein PTX3 that is encoded in the genome of human.


(1->3)-beta-D-glucan binding

description: Binding to a (1->3)-beta-D-glucan.


MOES_HUMAN Moesin (sprot)

A moesin that is encoded in the genome of human.


T cell aggregation

description: The adhesion of one T cell to one or more other T cells via adhesion molecules.


name: PTN3_HUMAN Tyrosine-protein phosphatase non-receptor type 3 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 3 that is encoded in the genome of human.


name: regulation of membrane depolarization during action potential

description: Any process that modulates the rate, frequency or extent of membrane depolarization during an action potential. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential.


name: DDX6_HUMAN Probable ATP-dependent RNA helicase DDX6 (sprot)

description: A probable ATP-dependent RNA helicase DDX6 that is encoded in the genome of human.


P-body assembly

description: The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.


CTNA2_HUMAN Catenin alpha-2 (sprot)

A catenin alpha-2 that is encoded in the genome of human.


name: DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (sprot)

description: A DNA (cytosine-5)-methyltransferase 1 that is encoded in the genome of human.


description: Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.


name: epigenetic programming of gene expression

description: A epigenetic process that happens during embryonic development that modulates gene expression potential at later stages of development of the organism, including the adult. Epigenetic regulation takes place via chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine DNA methylation.


name: chromosomal DNA methylation maintenance following DNA replication

description: The process that maintains methylated cytosine in newly synthesized DNA following DNA replication. After the establishment of novel DNA methylation marks, the newly created patterns must be faithfully transmitted by maintenance DNA methyltransferases during cell division.


cellular response to bisphenol A

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus.


name: negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

description: Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching.


name: PAX6_HUMAN Paired box protein Pax-6 (sprot)

description: A paired box protein Pax-6 that is encoded in the genome of human.


type B pancreatic cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.


pancreatic A cell development

description: The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon.


rhombomere morphogenesis

description: The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.


oligodendrocyte cell fate specification

description: The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.


forebrain-midbrain boundary formation

description: The process whose specific outcome is the creation of the forebrain-midbrain boundary.


habenula development

description: The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland.


interkinetic nuclear migration

description: The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle.


name: olfactory bulb mitral cell layer development

description: The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer.


name: learned vocalization behavior or vocal learning

description: Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned.


name: positive regulation of glutamatergic neuron differentiation

description: Any process that activates or increases the frequency, rate or extent of glutamatergic neuron differentiation.


sensory neuron migration

description: The orderly movement of a sensory neuron from one site to another.


name: U2AF2_HUMAN Splicing factor U2AF 65 kDa subunit (sprot)

description: A splicing factor U2AF 65 kDa subunit that is encoded in the genome of human.


U2AF complex

description: A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point.


name: KRA59_HUMAN Keratin-associated protein 5-9 (sprot)

description: A keratin-associated protein 5-9 that is encoded in the genome of human.


name: RL13_HUMAN Large ribosomal subunit protein eL13 (sprot)

description: A large ribosomal subunit protein eL13 that is encoded in the genome of human.


name: RAE2_HUMAN Rab proteins geranylgeranyltransferase component A 2 (sprot)

description: A Rab proteins geranylgeranyltransferase component A 2 that is encoded in the genome of human.


ELAV4_HUMAN ELAV-like protein 4 (sprot)

An ELAV-like protein 4 that is encoded in the genome of human.


name: pre-mRNA intronic pyrimidine-rich binding

description: Binding to a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA).


name: positive regulation of 3'-UTR-mediated mRNA stabilization

description: Any process that activates or increases the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization.


name: ASPX_HUMAN Acrosomal protein SP-10 (sprot)

description: An acrosomal protein SP-10 that is encoded in the genome of human.