meiotic cell cycle

description: Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.


name: negative regulation of cell cycle phase transition

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition.


name: regulation of cell cycle phase transition

description: Any process that modulates the frequency, rate or extent of cell cycle phase transition.


regulation of meiotic cell cycle

description: Any process that modulates the rate or extent of progression through the meiotic cell cycle.


regulation of translational initiation

description: Any process that modulates the frequency, rate or extent of translational initiation.


regulation of nuclear division

description: Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.


Set1C/COMPASS complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.


histone binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.


name: B BOX AND SPRY DOMAIN-CONTAINING PROTEIN


name: TRIPARTITE MOTIF-CONTAINING PROTEIN 43-RELATED


name: TRIPARTITE MOTIF-CONTAINING PROTEIN 73-RELATED


name: TRIPARTITE MOTIF-CONTAINING PROTEIN 64-RELATED


name: TRIPARTITE MOTIF-CONTAINING PROTEIN 49-RELATED


name: TRIPARTITE MOTIF-CONTAINING PROTEIN 51G-RELATED


name: TRIPARTITE MOTIF-CONTAINING PROTEIN 61-RELATED


name: E3 UBIQUITIN-PROTEIN LIGASE TRIML1-RELATED


name: E3 UBIQUITIN-PROTEIN LIGASE TRIML2-RELATED


name: TRIPARTITE MOTIF-CONTAINING PROTEIN 49B-RELATED


sarcolemma

description: The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.


name: positive regulation of DNA-binding transcription factor activity

description: Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.


name: positive regulation of canonical NF-kappaB signal transduction

description: Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade.


name: positive regulation of NF-kappaB transcription factor activity

description: Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.


name: regulation of canonical NF-kappaB signal transduction

description: Any process that modulates the canonical NF-kappaB signaling cascade.


regulation of catabolic process

description: Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.


regulation of macroautophagy

description: Any process that modulates the frequency, rate or extent of macroautophagy.


positive regulation of macroautophagy

description: Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.


name: positive regulation of catabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.


positive regulation of autophagy

description: Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.


name: positive regulation of cellular catabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.


regulation of autophagy

description: Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.


name: regulation of cellular catabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.


regulation of protein stability

description: Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.


protein stabilization

description: Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.


protein K63-linked ubiquitination

description: A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.


name: POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING


name: BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD21


name: BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD12


name: BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD19


name: BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD16


name: BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD18


name: BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD15


name: BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD11


name: BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD14


receptor complex

description: Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.


transcription corepressor activity

description: A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.


transcription factor binding

description: Binding to a transcription factor, a protein required to initiate or regulate transcription.


name: positive regulation of transporter activity

description: Any process that activates or increases the activity of a transporter.


positive regulation of transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: regulation of G protein-coupled receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.


regulation of potassium ion transport

description: Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: regulation of potassium ion transmembrane transport

description: Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport.


name: negative regulation of monoatomic ion transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: ZINC FINGER PROTEIN INTERACTING WITH RIBONUCLEOPROTEIN K


name: ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 5


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 10


name: ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 7


name: PROTEIN PHOSPHATASE INHIBITOR 2 FAMILY MEMBER C


name: PROTEIN PHOSPHATASE INHIBITOR 2 FAMILY MEMBER B


regulation of phosphatase activity

description: Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing phosphate.


regulation of dephosphorylation

description: Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule.


name: regulation of phosphoprotein phosphatase activity

description: Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.


protein-folding chaperone binding

description: Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.


protein folding

description: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.


name: DNA exonuclease activity, producing 5'-phosphomonoesters

description: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.


DNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.


5'-3' exonuclease activity

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.


name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.


single-stranded DNA binding

description: Binding to single-stranded DNA.


damaged DNA binding

description: Binding to damaged DNA.


exonuclease activity

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.


double-stranded RNA binding

description: Binding to double-stranded RNA.


name: citrate transmembrane transporter activity

description: Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other.


neutral amino acid transport

description: The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


amino acid transport

description: The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


carboxylic acid transmembrane transport

description: The process in which carboxylic acid is transported across a membrane.


amino acid transmembrane transport

description: The process in which an amino acid is transported across a membrane.


organic acid transmembrane transport

description: The process in which an organic acid is transported across a membrane.


mitochondrial transmembrane transport

description: The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion.


citrate transport

description: The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


tricarboxylic acid transport

description: The directed movement of tricarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


leading edge membrane

description: The portion of the plasma membrane surrounding the leading edge of a motile cell.


dendritic spine

description: A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.


regulation of synapse organization

description: Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).


endocytic recycling

description: The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.


name: regulation of postsynaptic membrane neurotransmitter receptor levels

description: Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane.


name: negative regulation of cell communication

description: Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


protein localization to synapse

description: Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.


negative regulation of signaling

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.


protein localization to cell junction

description: A process in which a protein is transported to, or maintained in, a location within a cell junction.


name: negative regulation of signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.


protein-containing complex localization

description: A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.


name: negative regulation of intracellular signal transduction

description: Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.


name: neurotransmitter receptor transport to postsynaptic membrane

description: The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles.


name: negative regulation of small GTPase mediated signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction.


regulation of postsynapse organization

description: Any process that modulates the physical form of a postsynapse.


name: vesicle-mediated transport to the plasma membrane

description: The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis.


name: CYSTEINE-RICH PROTEIN CRIP FAMILY MEMBER


protein-DNA complex organization

description: Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex.


protein-DNA complex assembly

description: The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.


chromatin organization

description: The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.


chromatin remodeling

description: A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.


name: Insulin/IGF pathway-protein kinase B signaling cascade

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


phosphatidylinositol 3-kinase binding

description: Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.


response to insulin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.


response to peptide hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.


cellular response to hormone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.


response to peptide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.


cellular response to insulin stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.


insulin receptor signaling pathway

description: The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.


cellular response to peptide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.


name: cellular response to peptide hormone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.


response to hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.


cysteine-type endopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


microautophagy

description: A type of autophagy where cytosolic components are ingested by late endosomes, lysosomes or yeast-type lytic vacuoles by direct invagination of the compartment membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane.


mitophagy

description: The selective autophagy process in which a mitochondrion is degraded by macroautophagy.


autophagy of mitochondrion

description: The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions.


vacuole organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.


protein lipidation

description: The covalent attachment of lipid groups to an amino acid in a protein.


lipoprotein biosynthetic process

description: The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.


autophagosome assembly

description: The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.


lipoprotein metabolic process

description: The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.


piecemeal microautophagy of the nucleus

description: Degradation of a cell nucleus by microautophagy.


name: LOW AFFINITY IMMUNOGLOBULIN EPSILON FC RECEPTOR


name: C-TYPE LECTIN DOMAIN FAMILY 17, MEMBER A


carbohydrate binding

description: Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.


monosaccharide binding

description: Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.


defense response to fungus

description: Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.


name: IMMUNOGLOBULIN SUBTYPE DOMAIN-CONTAINING PROTEIN


name: PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT ALPHA1


name: PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT ALPHA2


name: acyltransferase activity, transferring groups other than amino-acyl groups

description: Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).


acetyltransferase activity

description: Catalysis of the transfer of an acetyl group to an acceptor molecule.


name: ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 5


name: ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 2


name: ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 7


name: ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 3


name: ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 1


lysophospholipase activity

description: Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine.


phosphoric diester hydrolase activity

description: Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.


glycerolipid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone.


glycerophospholipid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.


organophosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound.


phospholipid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.


cellular lipid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.


name: nucleoside triphosphate metabolic process

description: The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.


nucleoside phosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate.


name: nucleoside triphosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.


name: ribonucleoside triphosphate metabolic process

description: The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.


ATP metabolic process

description: The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.


name: purine ribonucleoside triphosphate metabolic process

description: The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.


name: purine nucleoside triphosphate metabolic process

description: The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.


name: POGO TRANSPOSABLE ELEMENT WITH ZNF DOMAIN


name: ZINC FINGER-CONTAINING UBIQUITIN PEPTIDASE 1


positive regulation of cell development

description: Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.


regulation of cell development

description: Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.


name: positive regulation of nervous system development

description: Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.


regulation of neurogenesis

description: Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.


positive regulation of neurogenesis

description: Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.


name: regulation of nervous system development

description: Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.


name: GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR


name: GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR RECEPTOR SUBUNIT ALPHA


name: CILIARY NEUROTROPHIC FACTOR RECEPTOR SUBUNIT ALPHA


name: ONCOSTATIN-M-SPECIFIC RECEPTOR SUBUNIT BETA


peptide hormone binding

description: Binding to a peptide with hormonal activity in animals.


peptide binding

description: Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds.


amide binding

description: Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.


hormone binding

description: Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor.


cytokine receptor binding

description: Binding to a cytokine receptor.


cytokine-mediated signaling pathway

description: The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: regulation of peptidyl-tyrosine phosphorylation

description: Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.


name: positive regulation of peptidyl-tyrosine phosphorylation

description: Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.


name: positive regulation of tyrosine phosphorylation of STAT protein

description: Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


name: regulation of receptor signaling pathway via JAK-STAT

description: Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT.


name: regulation of receptor signaling pathway via STAT

description: Any process that modulates the frequency, rate or extent of receptor signaling via STAT.


name: positive regulation of receptor signaling pathway via JAK-STAT

description: Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.


name: DNA-binding transcription activator activity, RNA polymerase II-specific

description: A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.


name: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS


name: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET


name: PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA


name: HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR


name: RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3


name: INACTIVE TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR1


name: TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR2


name: EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1


name: PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA


name: MAST_STEM CELL GROWTH FACTOR RECEPTOR KIT


name: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2


name: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1


name: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3


name: MUSCLE, SKELETAL RECEPTOR TYROSINE-PROTEIN KINASE


name: MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR


name: plasma membrane signaling receptor complex

description: Any protein complex that is part of the plasma membrane and which functions as a signaling receptor.


basal plasma membrane

description: The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.


basal part of cell

description: The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.


fibroblast growth factor binding

description: Binding to a fibroblast growth factor.


Wnt-protein binding

description: Binding to a Wnt-protein, a secreted growth factor involved in signaling.


collagen binding

description: Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).


growth factor receptor binding

description: Binding to a growth factor receptor.


name: regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

description: Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction.


name: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

description: Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction.


regulation of TOR signaling

description: Any process that modulates the frequency, rate or extent of TOR signaling.


regulation of JNK cascade

description: Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.


glucose homeostasis

description: Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.


name: insulin-like growth factor receptor signaling pathway

description: The series of molecular signals initiated by a ligand binding to an insulin-like growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


carbohydrate homeostasis

description: A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell.


mononuclear cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell.


B cell activation

description: The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


leukocyte activation

description: A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.


lymphocyte activation

description: A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.


cell activation

description: A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell.


B cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.


lymphocyte differentiation

description: The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.


cell population proliferation

description: The multiplication or reproduction of cells, resulting in the expansion of a cell population.


epithelial cell proliferation

description: The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.


endothelial cell proliferation

description: The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.


regulation of neuron differentiation

description: Any process that modulates the frequency, rate or extent of neuron differentiation.


name: negative regulation of programmed cell death

description: Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.


name: negative regulation of apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.


chordate embryonic development

description: The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.


embryonic organ development

description: Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


embryo development

description: The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.


embryonic morphogenesis

description: The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.


name: hematopoietic progenitor cell differentiation

description: The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.


regulation of MAP kinase activity

description: Any process that modulates the frequency, rate or extent of MAP kinase activity.


name: regulation of protein serine/threonine kinase activity

description: Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity.


name: positive regulation of protein serine/threonine kinase activity

description: Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.


phagocytosis

description: A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.


endocytosis

description: A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle.


regulation of body fluid levels

description: Any process that modulates the levels of body fluids.


platelet activation

description: A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.


hemostasis

description: The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.


coagulation

description: The process in which a fluid solution, or part of it, changes into a solid or semisolid mass.


blood coagulation

description: The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.


endothelial cell differentiation

description: The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.


epithelium development

description: The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.


epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.


name: positive regulation of epithelial cell proliferation

description: Any process that activates or increases the rate or extent of epithelial cell proliferation.


name: regulation of lipid biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.


regulation of lipid metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.


name: SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE


name: HEPATIC AND GLIAL CELL ADHESION MOLECULE


name: LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 3


name: V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 5


name: CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 21


T cell activation

description: The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


filopodium assembly

description: The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.


positive regulation of synapse assembly

description: Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.


adaptive immune response

description: An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).


name: positive regulation of cytokine production

description: Any process that activates or increases the frequency, rate or extent of production of a cytokine.


immune effector process

description: Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation.


name: lymphocyte activation involved in immune response

description: A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


cell fate commitment

description: The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate.


name: cell activation involved in immune response

description: A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.


T cell differentiation

description: The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.


name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

description: An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.


name: leukocyte activation involved in immune response

description: A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


name: T cell activation involved in immune response

description: The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.


regulation of macrophage activation

description: Any process that modulates the frequency or rate of macrophage activation.


name: STE20-RELATED KINASE ADAPTER PROTEIN ALPHA


name: STE20-RELATED KINASE ADAPTER PROTEIN BETA


name: protein serine/threonine kinase activator activity

description: Binds to and increases the activity of a protein serine/threonine kinase.


protein export from nucleus

description: The directed movement of a protein from the nucleus into the cytoplasm.


nuclear transport

description: The directed movement of substances into, out of, or within the nucleus.


nuclear export

description: The directed movement of substances out of the nucleus.


nucleocytoplasmic transport

description: The directed movement of molecules between the nucleus and the cytoplasm.


name: T-CELL RECEPTOR-ASSOCIATED TRANSMEMBRANE ADAPTER 1


name: TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED


name: TATA-BOX-BINDING PROTEIN-ASSOCIATED FACTOR 11-LIKE PROTEIN 10-RELATED


name: TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 11 LIKE PROTEIN 2-RELATED


name: TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11


DNA-directed RNA polymerase complex

description: A protein complex that possesses DNA-directed RNA polymerase activity.


name: RNA polymerase II transcription regulator complex

description: A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.


transcription factor TFIID complex

description: A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.


RNA polymerase II, holoenzyme

description: A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters.


RNA polymerase complex

description: Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits.


transcription regulator complex

description: A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.


name: nuclear DNA-directed RNA polymerase complex

description: A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity.


DNA-templated transcription

description: The synthesis of an RNA transcript from a DNA template.


name: RNA polymerase II preinitiation complex assembly

description: The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA.


name: transcription initiation at RNA polymerase II promoter

description: A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.


DNA-templated transcription initiation

description: The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.


RNA biosynthetic process

description: The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.


transcription by RNA polymerase II

description: The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).


name: CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 2


name: CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1


name: EUKARYOTIC TRANSLATION INITIATION FACTOR 1A, Y-CHROMOSOMAL


name: EUKARYOTIC TRANSLATION INITIATION FACTOR 1A, X-CHROMOSOMAL


name: hydrolase activity, acting on glycosyl bonds

description: Catalysis of the hydrolysis of any glycosyl bond.


name: hydrolase activity, hydrolyzing O-glycosyl compounds

description: Catalysis of the hydrolysis of any O-glycosyl bond.


name: carbohydrate derivative catabolic process

description: The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative.


glycolipid metabolic process

description: The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent.


liposaccharide metabolic process

description: The chemical reactions and pathways involving liposaccharide.


sphingolipid metabolic process

description: The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


ceramide metabolic process

description: The chemical reactions and pathways involving ceramides, any N-acylated sphingoid.


membrane lipid metabolic process

description: The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane.


carbohydrate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.


sphingolipid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


carbohydrate metabolic process

description: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.


cytosolic ribosome

description: A ribosome located in the cytosol.


cytosolic large ribosomal subunit

description: The large subunit of a ribosome located in the cytosol.


large ribosomal subunit

description: The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).


ribosome

description: An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.


ribosomal subunit

description: Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit.


structural constituent of ribosome

description: The action of a molecule that contributes to the structural integrity of the ribosome.


structural molecule activity

description: The action of a molecule that contributes to the structural integrity of a complex.


rRNA binding

description: Binding to a ribosomal RNA.


name: MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN


name: CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 3


name: CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 6


name: CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1


name: CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 5


name: CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 8


name: CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 7


name: CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 4


name: CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2


name: U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT


name: U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35 KDA SUBUNIT-RELATED PROTEIN 1-RELATED


name: U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35 KDA SUBUNIT-RELATED PROTEIN 2


pre-mRNA binding

description: Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.


mRNA metabolic process

description: The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.


name: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

description: Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure.


mRNA processing

description: Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.


name: RNA splicing, via transesterification reactions

description: Splicing of RNA via a series of two transesterification reactions.


mRNA splicing, via spliceosome

description: The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.


name: WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 1


name: WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 2


transforming growth factor beta binding

description: Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types.


name: VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 33A


name: VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 45


name: VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 33B


secretory granule

description: A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.


vesicle tethering complex

description: Any protein complex that plays a role in vesicle tethering.


syntaxin binding

description: Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.


SNARE binding

description: Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.


signal release

description: The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.


neurotransmitter secretion

description: The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.


exocytic process

description: The cellular processes that contribute to exocytosis.


signal release from synapse

description: Any signal release from a synapse.


exocytosis

description: A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.


nucleolus

description: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.


name: rRNA (guanine) methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine.


catalytic activity, acting on a rRNA

description: Catalytic activity that acts to modify a ribosomal RNA.


rRNA methyltransferase activity

description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule.


RNA methyltransferase activity

description: Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.


rRNA processing

description: Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.


RNA modification

description: The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.


rRNA modification

description: The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically.


ribosome biogenesis

description: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.


rRNA methylation

description: The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.


methylation

description: The process in which a methyl group is covalently attached to a molecule.


macromolecule methylation

description: The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.


rRNA metabolic process

description: The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes.


ribonucleoprotein complex biogenesis

description: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex.


rRNA base methylation

description: The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.


RNA methylation

description: Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor.


name: NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN


name: NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 1-RELATED


name: NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 4-RELATED


name: NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 7-RELATED


name: NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 3


name: phosphotransferase activity, phosphate group as acceptor

description: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor).


name: phosphatidylinositol phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.


UDP-xylosyltransferase activity

description: Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule.


xylosyltransferase activity

description: Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


pentosyltransferase activity

description: Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor).


name: RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 37


name: RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 38


name: HIGH AFFINITY CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 7A


name: DUAL 3',5'-CYCLIC-AMP AND -GMP PHOSPHODIESTERASE 11A


name: CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA'


name: HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A


name: HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8A


name: CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A


name: CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 7B


name: HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8B


name: CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A


name: ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA


name: ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA


name: CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D


name: DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1A


name: DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1B


name: CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4C


name: DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1C


name: CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B


perinuclear region of cytoplasm

description: Cytoplasm situated near, or occurring around, the nucleus.


mitochondrial outer membrane

description: The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.


organelle outer membrane

description: The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope.


mitochondrial matrix

description: The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.


outer membrane

description: The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.


9+0 non-motile cilium

description: A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme).


non-motile cilium

description: A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.


ciliary membrane

description: The portion of the plasma membrane surrounding a cilium.


cell projection membrane

description: The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.


photoreceptor outer segment

description: The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.


name: Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction


description: Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.


cAMP-mediated signaling

description: An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell.


regulation of cAMP-mediated signaling

description: Any process which modulates the frequency, rate or extent of cAMP-mediated signaling.


name: negative regulation of cAMP-mediated signaling

description: Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling.


visual perception

description: The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.


cyclic nucleotide metabolic process

description: The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.


ribonucleotide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


name: regulation of mitochondrion organization

description: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.


purine ribonucleotide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


nucleotide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).


name: purine-containing compound catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof.


purine nucleotide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


cGMP-mediated signaling

description: An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell.


detection of mechanical stimulus

description: The series of events by which a mechanical stimulus is received and converted into a molecular signal.


response to mechanical stimulus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.


sensory perception of sound

description: The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.


response to abiotic stimulus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.


name: sensory perception of mechanical stimulus

description: The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


name: 39S RIBOSOMAL PROTEIN L55, MITOCHONDRIAL


mitochondrial large ribosomal subunit

description: The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).


mitochondrial ribosome

description: A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes.


organellar ribosome

description: A ribosome contained within a subcellular membrane-bounded organelle.


name: TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1


cytoplasmic side of plasma membrane

description: The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.


name: SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG


name: HETEROCHROMATIN PROTEIN 1-BINDING PROTEIN 3


nucleosome binding

description: Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.


chromatin binding

description: Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.


heterochromatin organization

description: Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin.


name: ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN


palmitoyltransferase activity

description: Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule.


protein palmitoylation

description: The covalent attachment of a palmitoyl group to a protein.


protein acylation

description: The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid.


protein targeting to membrane

description: The process of directing proteins towards a membrane, usually using signals contained within the protein.


vesicle organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.


cell division site

description: The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.


cell cortex

description: The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.


cell division

description: The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.


cytoskeleton-dependent cytokinesis

description: A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton.


cytokinesis

description: The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.


name: N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE 2


name: INACTIVE N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE-LIKE PROTEIN 2


intracellular iron ion homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell.


iron ion transport

description: The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


transition metal ion transport

description: The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.


receptor-mediated endocytosis

description: An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.


trans-Golgi network

description: The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.


recycling endosome

description: An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.


Golgi apparatus subcompartment

description: A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi apparatus.


name: GPI-LINKED NAD(P)(+)--ARGININE ADP-RIBOSYLTRANSFERASE 1


microvillus

description: Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.


actin-based cell projection

description: A cell projection supported by an assembly of actin filaments, and which lacks microtubules.


name: regulation of cell adhesion mediated by integrin

description: Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.


name: COILED-COIL DOMAIN-CONTAINING PROTEIN 28B


name: COILED-COIL DOMAIN-CONTAINING PROTEIN 28A


name: E3 UBIQUITIN-PROTEIN LIGASE DTX3-RELATED


name: E3 UBIQUITIN-PROTEIN LIGASE DTX2-RELATED


Notch signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER


name: adenylate cyclase-activating G protein-coupled receptor signaling pathway

description: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling.


regulation of anatomical structure size

description: Any process that modulates the size of an anatomical structure.


regulation of blood pressure

description: Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.


name: negative regulation of inflammatory response

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.


negative regulation of defense response

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response.


name: PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP10


name: PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP9


chromatin DNA binding

description: Binding to DNA that is assembled into chromatin.


heterochromatin formation

description: An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation.


name: negative regulation of gene expression, epigenetic

description: An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation.


name: epigenetic regulation of gene expression

description: A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal.


name: regulation of transcription by RNA polymerase I

description: Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I.


name: LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN


name: LETM1 DOMAIN-CONTAINING PROTEIN LETM2, MITOCHONDRIAL


name: MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN


name: STAR-RELATED LIPID TRANSFER PROTEIN 7, MITOCHONDRIAL


name: SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 26


name: INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 29


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 47


name: UBL CARBOXYL-TERMINAL HYDROLASE 18-RELATED


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE FAF-Y-RELATED


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 37


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 13


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 40


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 28


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 42


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 38


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 25


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 46


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 35


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 24


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 12


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE FAF-X-RELATED


mitotic cell cycle phase transition

description: The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.


cell cycle G1/S phase transition

description: The cell cycle process by which a cell in G1 phase commits to S phase.


cell cycle phase transition

description: The cell cycle process by which a cell commits to entering the next cell cycle phase.


G1/S transition of mitotic cell cycle

description: The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.


DNA damage checkpoint signaling

description: A signal transduction process that contributes to a DNA damage checkpoint.


cell cycle checkpoint signaling

description: A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.


name: signal transduction in response to DNA damage

description: A cascade of processes induced by the detection of DNA damage within a cell.


DNA integrity checkpoint signaling

description: A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes.


name: TESTIS-SPECIFIC Y-ENCODED PROTEIN 1-RELATED


name: TESTIS-SPECIFIC Y-ENCODED-LIKE PROTEIN 5


name: TESTIS-SPECIFIC Y-ENCODED-LIKE PROTEIN 6


name: TESTIS-SPECIFIC Y-ENCODED-LIKE PROTEIN 1


name: TESTIS-SPECIFIC Y-ENCODED-LIKE PROTEIN 3-RELATED


name: TESTIS-SPECIFIC Y-ENCODED-LIKE PROTEIN 4


name: TESTIS-SPECIFIC Y-ENCODED-LIKE PROTEIN 2


nucleosome organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes.


nucleosome assembly

description: The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.


name: FORKHEAD-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1-RELATED


name: COILED-COIL DOMAIN-CONTAINING PROTEIN 27


name: FORKHEAD-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1


name: secondary active transmembrane transporter activity

description: Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters.


symporter activity

description: Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.


name: active monoatomic ion transmembrane transporter activity

description: Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction.


name: active transmembrane transporter activity

description: Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.


name: solute:monoatomic cation symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).


name: ubiquitin-like protein conjugating enzyme binding

description: Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme.


protein neddylation

description: Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.


name: HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 4


name: HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 3B1


name: HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 6


name: HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 2


name: HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 3A1


name: BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE 2


name: BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE 1


name: BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE 4


name: HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 1


name: BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE 3


name: HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 5


deacetylase activity

description: Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.


carbohydrate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.


polysaccharide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.


polysaccharide metabolic process

description: The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.


name: ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 1


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 29


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 5C


name: ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 8


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 23


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 21


name: ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 4


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 4


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 32


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 25


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 26


name: ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 3


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 41


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 22


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 5A-RELATED


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 16


name: ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 2


name: NEUROTROPHIN RECEPTOR-INTERACTING FACTOR HOMOLOG


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 20


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 31


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 12


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 18


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 9


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 5B


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 1


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 30


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12A


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12B


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12C


name: PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 16B


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 16A


Z disc

description: Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.


A band

description: The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.


I band

description: A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.


name: AP-1 COMPLEX-ASSOCIATED REGULATORY PROTEIN


organelle membrane contact site

description: A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions.


cholesterol transfer activity

description: Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


sterol transfer activity

description: Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


lipid transfer activity

description: Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids.


steroid binding

description: Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.


sterol binding

description: Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.


lipid transporter activity

description: Enables the directed movement of lipids into, out of or within a cell, or between cells.


cholesterol binding

description: Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


organic hydroxy compound transport

description: The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom.


sterol transport

description: The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


intracellular sterol transport

description: The directed movement of sterols within cells.


intracellular lipid transport

description: The directed movement of lipids within cells.


name: CHONDROITIN SULFATE N-ACETYLGALACTOSAMINYLTRANSFERASE 2


name: CHONDROITIN SULFATE N-ACETYLGALACTOSAMINYLTRANSFERASE 1


name: DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING


dorsal/ventral pattern formation

description: The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.


name: BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR HOMOLOG


G protein-coupled receptor binding

description: Binding to a G protein-coupled receptor.


name: actin polymerization or depolymerization

description: Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.


actin filament polymerization

description: Assembly of actin filaments by the addition of actin monomers to a filament.


protein polymerization

description: The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein.


name: KERATINOCYTE-ASSOCIATED TRANSMEMBRANE PROTEIN 2


name: Dopamine receptor mediated signaling pathway


name: KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 12


name: KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 6


name: KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 3


name: KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 8


name: KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 7


name: KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 2


name: COPII-coated ER to Golgi transport vesicle

description: A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport).


name: vesicle targeting, to, from or within Golgi

description: The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation.


protein monoubiquitination

description: Addition of a single ubiquitin group to a protein.


vesicle targeting

description: The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo.


vesicle budding from membrane

description: The evagination of a membrane, resulting in formation of a vesicle.


COPII-coated vesicle budding

description: The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle.


name: METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED


name: BETA_GAMMA CRYSTALLIN DOMAIN-CONTAINING PROTEIN 1


name: BETA_GAMMA CRYSTALLIN DOMAIN-CONTAINING PROTEIN 2