name: unsaturated fatty acid metabolic process

description: The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.


name: unsaturated fatty acid biosynthetic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.


small molecule biosynthetic process

description: The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.


carboxylic acid metabolic process

description: The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).


fatty acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.


small molecule metabolic process

description: The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.


name: BUTYROPHILIN SUBFAMILY 2 MEMBER A3-RELATED


name: BUTYROPHILIN-LIKE PROTEIN 10 PSEUDOGENE-RELATED


name: V-SET DOMAIN-CONTAINING T-CELL ACTIVATION INHIBITOR 1


name: immune response-regulating signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response.


name: antigen receptor-mediated signaling pathway

description: The series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell.


activation of immune response

description: Any process that initiates an immune response.


name: positive regulation of response to stimulus

description: Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.


positive regulation of immune response

description: Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.


name: immune response-regulating cell surface receptor signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.


regulation of immune response

description: Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.


name: immune response-activating cell surface receptor signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a cell, leading to the activation or perpetuation of an immune response.


name: immune response-activating signaling pathway

description: The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response.


T cell receptor signaling pathway

description: The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.


name: DENN DOMAIN-CONTAINING PROTEIN 10-RELATED


category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binds to and modulates the activity of an NTPase.


GTPase regulator activity

description: Binds to and modulates the activity of a GTPase.


small GTPase binding

description: Binding to a small monomeric GTPase.


name: guanyl-nucleotide exchange factor activity

description: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.


regulation of cellular localization

description: Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.


name: regulation of vesicle-mediated transport

description: Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.


osteoclast differentiation

description: The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.


hemopoiesis

description: The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.


myeloid cell differentiation

description: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.


leukocyte differentiation

description: The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.


name: INACTIVE GROUP IIC SECRETORY PHOSPHOLIPASE A2-RELATED


carboxylic ester hydrolase activity

description: Catalysis of the hydrolysis of a carboxylic ester bond.


lipase activity

description: Catalysis of the hydrolysis of a lipid or phospholipid.


phospholipase A2 activity

description: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.


calcium ion binding

description: Binding to a calcium ion (Ca2+).


phospholipase activity

description: Catalysis of the hydrolysis of a glycerophospholipid.


phospholipid binding

description: Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.


phospholipid metabolic process

description: The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.


organophosphate metabolic process

description: The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound.


phosphatidylinositol 3-kinase complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.


catalytic complex

description: A protein complex which is capable of catalytic activity.


transferase complex

description: A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).


name: phosphatidylinositol 3-kinase complex, class III

description: A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI).


name: transferase complex, transferring phosphorus-containing groups

description: A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).


phospholipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.


organophosphate biosynthetic process

description: The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose.


description: The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.


glycerolipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone.


phosphatidylinositol metabolic process

description: The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.


glycerophospholipid metabolic process

description: The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.


glycerolipid metabolic process

description: The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.


description: The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.


protein-DNA complex

description: A macromolecular complex containing both protein and DNA molecules.


chromatin

description: The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.


ATPase complex

description: A protein complex which is capable of ATPase activity.


SWI/SNF superfamily-type complex

description: A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP.


chromosome

description: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.


membrane-enclosed lumen

description: The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.


histone methyltransferase complex

description: A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.


organelle lumen

description: The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.


nucleoplasm

description: That part of the nuclear content other than the chromosomes or the nucleolus.


intracellular organelle lumen

description: An organelle lumen that is part of an intracellular organelle.


methyltransferase complex

description: A protein complex that possesses methyltransferase activity.


nuclear lumen

description: The volume enclosed by the nuclear inner membrane.


N-methyltransferase activity

description: Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule.


histone modifying activity

description: A catalytic activity that acts on a histone protein. Reversible histone modifications contribute to regulation of gene expression.


histone methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue.


protein-macromolecule adaptor activity

description: The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.


transcription coactivator activity

description: A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.


methyltransferase activity

description: Catalysis of the transfer of a methyl group to an acceptor molecule.


protein methyltransferase activity

description: Catalysis of the transfer of a methyl group (CH3-) to a protein.


transcription coregulator activity

description: A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.


molecular adaptor activity

description: The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.


histone H3K4 methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein.


name: transferase activity, transferring one-carbon groups

description: Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor).


description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.


description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.


lysine N-methyltransferase activity

description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue.


name: positive regulation of RNA biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process.


name: regulation of transcription by RNA polymerase II

description: Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.


name: positive regulation of transcription by RNA polymerase II

description: Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.


name: positive regulation of DNA-templated transcription

description: Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.


early endosome

description: A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.


coated vesicle

description: Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.


clathrin-coated vesicle

description: A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.


endocytic vesicle

description: A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.


phosphatase activity

description: Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.


phosphoric ester hydrolase activity

description: Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.


phospholipid dephosphorylation

description: The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.


phosphatidylinositol dephosphorylation

description: The process of removing one or more phosphate groups from a phosphatidylinositol.


lipid modification

description: The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid.


dephosphorylation

description: The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.


name: RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A


name: NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEIN


name: RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3


name: regulation of Rho protein signal transduction

description: Any process that modulates the frequency, rate or extent of Rho protein signal transduction.


name: positive regulation of signal transduction

description: Any process that activates or increases the frequency, rate or extent of signal transduction.


name: regulation of intracellular signal transduction

description: Any process that modulates the frequency, rate or extent of intracellular signal transduction.


name: regulation of small GTPase mediated signal transduction

description: Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.


name: positive regulation of cell communication

description: Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


name: positive regulation of intracellular signal transduction

description: Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.


positive regulation of signaling

description: Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.


axoneme

description: The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.


cytoplasmic region

description: Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm.


name: plasma membrane bounded cell projection cytoplasm

description: All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection.


ciliary plasm

description: All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.


axoneme assembly

description: The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.


retina development in camera-type eye

description: The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.


visual system development

description: The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways.


sensory system development

description: The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure.


microtubule bundle formation

description: A process that results in a parallel arrangement of microtubules.


eye development

description: The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.


camera-type eye development

description: The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.


sensory organ development

description: The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.


membrane raft

description: Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.


membrane microdomain

description: A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it.


GTPase activator activity

description: Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.


regulation of cell-matrix adhesion

description: Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.


name: positive regulation of cell-substrate adhesion

description: Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.


integrin-mediated signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


regulation of cell junction assembly

description: Any process that modulates the frequency, rate or extent of cell junction assembly.


regulation of cell-substrate adhesion

description: Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.


name: CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN


name: TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 1


name: BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN


name: NEURAL CELL ADHESION MOLECULE L1-LIKE PROTEIN


name: TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 2


mitochondrion

description: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.


nucleotide binding

description: Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.


nucleoside phosphate binding

description: Binding to nucleoside phosphate.


flavin adenine dinucleotide binding

description: Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.


heterocyclic compound binding

description: Binding to heterocyclic compound.


name: LEUCINE-RICH REPEAT AND CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN 1


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57


name: LEUCINE-RICH REPEAT AND CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN 2


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 10B


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 10


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 27


name: LEUCINE-RICH REPEAT AND CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN 4


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 20


sarcomere

description: The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


contractile muscle fiber

description: Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.


myofibril

description: The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.


nuclear body

description: Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.


PML body

description: A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.


negative regulation of locomotion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.


response to cytokine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.


regulation of lymphocyte migration

description: Any process that modulates the frequency, rate or extent of lymphocyte migration.


cellular response to cytokine stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.


regulation of leukocyte migration

description: Any process that modulates the frequency, rate, or extent of leukocyte migration.


negative regulation of cell motility

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.


negative regulation of cell migration

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.


muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a muscle cell.


cardiac muscle cell differentiation

description: The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.


cardiac muscle tissue development

description: The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.


muscle tissue development

description: The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.


muscle cell development

description: The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.


muscle structure development

description: The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.


striated muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.


striated muscle tissue development

description: The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.


name: FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 11


name: cis-regulatory region sequence-specific DNA binding

description: Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.


name: RNA polymerase II cis-regulatory region sequence-specific DNA binding

description: Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.


endopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.


name: 5HT2 type receptor mediated signaling pathway


name: Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway


name: Histamine H2 receptor mediated signaling pathway


name: 5HT4 type receptor mediated signaling pathway


name: G protein-coupled amine receptor activity

description: Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


neurotransmitter receptor activity

description: Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.


response to organic cyclic compound

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.


name: regulation of sequestering of calcium ion

description: Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.


cellular response to nitrogen compound

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.


name: phospholipase C-activating G protein-coupled receptor signaling pathway

description: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).


response to endogenous stimulus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.


name: cellular response to organic cyclic compound

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.


name: cellular response to endogenous stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.


name: release of sequestered calcium ion into cytosol

description: The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.


name: cellular response to organonitrogen compound

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.


name: negative regulation of sequestering of calcium ion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.


name: adenylate cyclase-modulating G protein-coupled receptor signaling pathway

description: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).


name: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

description: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP).


name: acetylcholine receptor signaling pathway

description: The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands.


regulation of muscle contraction

description: Any process that modulates the frequency, rate or extent of muscle contraction.


regulation of system process

description: Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.


regulation of muscle system process

description: Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.


name: CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN


name: CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN 2


name: CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN 1


carbohydrate derivative binding

description: Binding to a carbohydrate derivative.


sulfotransferase activity

description: Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.


name: transferase activity, transferring sulphur-containing groups

description: Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor).


glycosaminoglycan metabolic process

description: The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.


aminoglycan biosynthetic process

description: The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.


glycosaminoglycan biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.


amino sugar metabolic process

description: The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group.


aminoglycan metabolic process

description: The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.


name: chondroitin sulfate proteoglycan biosynthetic process

description: The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.


proteoglycan metabolic process

description: The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


proteoglycan biosynthetic process

description: The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


name: 25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL


name: 1,25-DIHYDROXYVITAMIN D(3) 24-HYDROXYLASE, MITOCHONDRIAL


name: ULTRA-LONG-CHAIN FATTY ACID OMEGA-HYDROXYLASE


monooxygenase activity

description: Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.


name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

description: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.


alcohol binding

description: Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group.


steroid hydroxylase activity

description: Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.


small molecule catabolic process

description: The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule.


name: organic hydroxy compound metabolic process

description: The chemical reactions and pathways involving organic hydroxy compound.


steroid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.


response to nutrient levels

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.


lipid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.


sterol metabolic process

description: The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


alcohol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.


cholesterol metabolic process

description: The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.


name: organic hydroxy compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of organic hydroxy compound.


alcohol metabolic process

description: The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.


secondary alcohol metabolic process

description: The chemical reactions and pathways involving secondary alcohol.


steroid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.


name: SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 5


name: SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 6


name: SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4


name: SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1


name: SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7


name: SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3


inorganic ion homeostasis

description: Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell.


calcium ion homeostasis

description: Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.


homeostatic process

description: Any biological process involved in the maintenance of an internal steady state.


monoatomic cation homeostasis

description: Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom.


cellular homeostasis

description: Any process involved in the maintenance of an internal steady state at the level of the cell.


chemical homeostasis

description: Any biological process involved in the maintenance of an internal steady state of a chemical.


name: regulation of cytosolic calcium ion concentration

description: Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.


intracellular chemical homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell.


intracellular calcium ion homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell.


monoatomic ion homeostasis

description: Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.


name: intracellular monoatomic cation homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom.


name: intracellular monoatomic ion homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.


fertilization

description: The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).


single fertilization

description: The union of male and female gametes to form a zygote.


name: NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2


name: NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF1


name: NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF4


name: NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3-RELATED


protein-membrane adaptor activity

description: The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle.


vesicle coat

description: A membrane coat found on a coated vesicle.


Golgi-associated vesicle membrane

description: The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.


COPI vesicle coat

description: One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state.


membrane coat

description: Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.


coated vesicle membrane

description: The lipid bilayer surrounding a coated vesicle.


COPI-coated vesicle

description: A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport.


Golgi-associated vesicle

description: Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.


coated membrane

description: A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes.


intra-Golgi vesicle-mediated transport

description: The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).


integrin binding

description: Binding to an integrin.


skeletal system development

description: The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).


name: negative regulation of DNA-templated transcription

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.


ossification

description: The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.


name: negative regulation of RNA metabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.


name: negative regulation of RNA biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process.


bone development

description: The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.


name: negative regulation of transcription by RNA polymerase II

description: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.


motor neuron axon guidance

description: The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.


regulation of defense response

description: Any process that modulates the frequency, rate or extent of a defense response.


regulation of inflammatory response

description: Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.


name: TRANSFORMING GROWTH FACTOR BETA-1 PROPROTEIN


name: TRANSFORMING GROWTH FACTOR BETA-3 PROPROTEIN


name: EMBRYONIC GROWTH_DIFFERENTIATION FACTOR 1


name: TRANSFORMING GROWTH FACTOR BETA-2 PROPROTEIN


name: Gonadotropin-releasing hormone receptor pathway


cytokine activity

description: The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells.


response to growth factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.


name: transforming growth factor beta receptor signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: response to transforming growth factor beta

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.


name: cellular response to transforming growth factor beta stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.


name: transforming growth factor beta receptor superfamily signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: cellular response to growth factor stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.


name: cell surface receptor protein serine/threonine kinase signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.


BMP signaling pathway

description: The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


cellular response to BMP stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus.


response to BMP

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus.


description: The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.


pattern specification process

description: Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.


regionalization

description: The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.


name: positive regulation of cell differentiation

description: Any process that activates or increases the frequency, rate or extent of cell differentiation.


name: positive regulation of developmental process

description: Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).


name: HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-36 SPECIFIC


name: SPERM AXONEMAL MAINTENANCE PROTEIN CFAP97D1


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56


name: PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3


name: RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2


name: PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1


name: PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 1


name: SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG


catalytic step 2 spliceosome

description: A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.


name: peptidyl-prolyl cis-trans isomerase activity

description: Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).


isomerase activity

description: Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.


acyltransferase activity

description: Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).


ubiquitin-protein transferase activity

description: Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.


name: ubiquitin-like protein transferase activity

description: Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.


ubiquitin protein ligase activity

description: Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.


ubiquitin-like protein ligase activity

description: Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate.


aminoacyltransferase activity

description: Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor).


protein peptidyl-prolyl isomerization

description: The modification of a protein by cis-trans isomerization of a proline residue.


peptidyl-amino acid modification

description: The alteration of an amino acid residue in a peptide.


protein ubiquitination

description: The process in which one or more ubiquitin groups are added to a protein.


name: protein modification by small protein conjugation or removal

description: A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.


post-translational protein modification

description: The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.


protein polyubiquitination

description: Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.


name: protein modification by small protein conjugation

description: A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein.


name: ADAMTS  A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS  PROTEASE


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 19


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 13


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 4


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 9


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 14


name: THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 4


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 7


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 16


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 15


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 3


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 17


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 20


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 5


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 12


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 2


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 8


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 1


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 18


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 6


name: A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 10


extracellular matrix

description: A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.


external encapsulating structure

description: A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.


metalloendopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD


cysteine-type peptidase activity

description: Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


name: ubiquitin-like protein peptidase activity

description: An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins.


deubiquitinase activity

description: An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.


cysteine-type deubiquitinase activity

description: An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.


protein K63-linked deubiquitination

description: A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein.


name: regulation of apoptotic signaling pathway

description: Any process that modulates the frequency, rate or extent of apoptotic signaling pathway.


name: negative regulation of NF-kappaB transcription factor activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.


name: positive regulation of programmed cell death

description: Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.


name: positive regulation of apoptotic signaling pathway

description: Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.


name: positive regulation of extrinsic apoptotic signaling pathway

description: Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.


name: positive regulation of apoptotic process

description: Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.


name: regulation of DNA-binding transcription factor activity

description: Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.


name: regulation of extrinsic apoptotic signaling pathway

description: Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway.


name: protein modification by small protein removal

description: A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein.


protein deubiquitination

description: The removal of one or more ubiquitin groups from a protein.


regulation of mitotic cell cycle

description: Any process that modulates the rate or extent of progress through the mitotic cell cycle.


name: regulation of intrinsic apoptotic signaling pathway

description: Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway.


name: negative regulation of DNA-binding transcription factor activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.


nucleotidyltransferase activity

description: Catalysis of the transfer of a nucleotidyl group to a reactant.


glutathione transferase activity

description: Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.


name: transferase activity, transferring alkyl or aryl (other than methyl) groups

description: Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).


name: guanyl-nucleotide exchange factor complex

description: A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.


actin filament organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.


actin cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.


nuclear chromosome segregation

description: The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.


sister chromatid segregation

description: The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.


nuclear division

description: The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.


chromosome segregation

description: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.


chromosome organization

description: A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.


mitotic spindle assembly

description: Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied.


spindle assembly

description: The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.


mitotic nuclear division

description: A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.


organelle fission

description: The creation of two or more organelles by division of one organelle.


mitotic sister chromatid segregation

description: The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.


non-membrane-bounded organelle assembly

description: The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle.


protein kinase binding

description: Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.


kinase binding

description: Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 45


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 51


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 27


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 11


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15


name: INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 50


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 31


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 43


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 22


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 20


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 19


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 44


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 49


name: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 33


nuclear envelope

description: The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).


organelle envelope

description: A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.


endoplasmic reticulum lumen

description: The volume enclosed by the membranes of the endoplasmic reticulum.


kinesin binding

description: Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.


protein localization to nucleus

description: A process in which a protein transports or maintains the localization of another protein to the nucleus.


nucleus organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.


nuclear envelope organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.


nuclear membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane.


description: The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.


phosphatidylcholine metabolic process

description: The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.


actin cytoskeleton

description: The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.


regulation of MAPK cascade

description: Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.


positive regulation of MAPK cascade

description: Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.


regulation of ERK1 and ERK2 cascade

description: Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.


name: positive regulation of ERK1 and ERK2 cascade

description: Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.


cytosolic transport

description: The directed movement of substances or organelles within the cytosol.


retrograde transport, endosome to Golgi

description: The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.


name: CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE


name: CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA


name: CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX-RELATED


name: CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA


name: CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA


serine/threonine protein kinase complex

description: A protein complex which is capable of protein serine/threonine kinase activity.


protein kinase complex

description: A protein complex which is capable of protein kinase activity.


protein kinase A binding

description: Binding to a protein kinase A.


name: protein serine/threonine kinase activity

description: Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.


name: protein kinase A regulatory subunit binding

description: Binding to one or both of the regulatory subunits of protein kinase A.


name: ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 2


name: FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I


actin filament binding

description: Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.


myofibril assembly

description: Formation of myofibrils, the repeating units of striated muscle.


striated muscle cell development

description: The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.


sarcomere organization

description: The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


name: cellular component assembly involved in morphogenesis

description: The cellular component assembly that is part of the initial shaping of the component during its developmental progression.


actomyosin structure organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.


cortical cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.


name: cortical actin cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.


name: RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY


name: RAS-RELATED AND ESTROGEN-REGULATED GROWTH INHIBITOR


GTPase activity

description: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.


calmodulin binding

description: Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.


name: small GTPase-mediated signal transduction

description: An intracellular signaling cassette in which a small monomeric GTPase relays a signal.


regulation of secretion by cell

description: Any process that modulates the frequency, rate or extent of secretion by cell.


name: regulation of neurotransmitter secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.


regulation of secretion

description: Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.


regulation of exocytosis

description: Any process that modulates the frequency, rate or extent of exocytosis.


negative regulation of transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: modulation of chemical synaptic transmission

description: Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.


regulation of trans-synaptic signaling

description: Any process that modulates the frequency, rate or extent of trans-synaptic signaling.


name: regulation of neuron projection development

description: Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).


ubiquitin ligase complex

description: A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.


nuclear ubiquitin ligase complex

description: A ubiquitin ligase complex found in the nucleus.


PcG protein complex

description: A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.


PRC1 complex

description: A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.


SUMO transferase activity

description: Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages.


SUMO ligase activity

description: Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S = X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate.


SUMO binding

description: Binding to the small ubiquitin-like protein SUMO.


protein sumoylation

description: The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.


name: MELANOMA-ASSOCIATED ANTIGEN  MAGE ANTIGEN


name: MAGE DOMAIN-CONTAINING PROTEIN MAGEA13P-RELATED


name: NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 3 HOMOLOG


histone deacetylase binding

description: Binding to histone deacetylase.


name: PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT BETA


kinetochore

description: A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.


name: condensed chromosome, centromeric region

description: The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.


condensed chromosome

description: A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.


chromosome, centromeric region

description: The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.


cytoplasmic microtubule

description: Any microtubule in the cytoplasm of a cell.


chromosomal region

description: Any subdivision of a chromosome along its length.


microtubule plus-end binding

description: Binding to the plus end of a microtubule.


dynein complex binding

description: Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.


vesicle transport along microtubule

description: The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.


name: establishment or maintenance of cell polarity

description: Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.


nuclear migration

description: The directed movement of the nucleus to a specific location within a cell.


organelle localization

description: Any process in which an organelle is transported to, and/or maintained in, a specific location.


establishment of spindle orientation

description: Any process that set the alignment of spindle relative to other cellular structures.


microtubule-based movement

description: A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.


establishment of cell polarity

description: The specification and formation of anisotropic intracellular organization or cell growth patterns.


axo-dendritic transport

description: The directed movement of organelles or molecules along microtubules in neuron projections.


establishment of vesicle localization

description: The directed movement of a vesicle to a specific location.


description: The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.


establishment of organelle localization

description: The directed movement of an organelle to a specific location.


spindle localization

description: Any process in which is the spindle is transported to, and/or maintained in, a specific location.


vesicle localization

description: Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location.


name: microtubule organizing center organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.


establishment of spindle localization

description: The directed movement of the spindle to a specific location in the cell.


transport along microtubule

description: The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.


name: establishment of mitotic spindle localization

description: The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs.


name: establishment of mitotic spindle orientation

description: A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.


microtubule-based transport

description: A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.


animal organ morphogenesis

description: Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


organelle transport along microtubule

description: The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.


vesicle cytoskeletal trafficking

description: The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins.


Cul3-RING ubiquitin ligase complex

description: A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.


cullin-RING ubiquitin ligase complex

description: Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.


cullin family protein binding

description: Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3).


regulation of cell division

description: Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.


regulation of cell cycle process

description: Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.


regulation of cytokinesis

description: Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.


name: protein quality control for misfolded or incompletely synthesized proteins

description: The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.


name: proteasome-mediated ubiquitin-dependent protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


name: cellular response to topologically incorrect protein

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure.


name: response to topologically incorrect protein

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure.


name: PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT  BACTERIAL AND ORGANELLAR


name: PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, SOMATIC FORM, MITOCHONDRIAL


name: PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, TESTIS-SPECIFIC FORM, MITOCHONDRIAL


purine nucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


name: purine-containing compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof.


nucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).


ribose phosphate metabolic process

description: The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar.


nucleoside phosphate metabolic process

description: The chemical reactions and pathways involving any phosphorylated nucleoside.


name: purine-containing compound metabolic process

description: The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof.


purine nucleotide metabolic process

description: The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


acyl-CoA metabolic process

description: The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.


ribose phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar.


ribonucleotide metabolic process

description: The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


purine ribonucleotide metabolic process

description: The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


ribonucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


name: nucleobase-containing compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.


nucleotide metabolic process

description: The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).


name: nucleoside phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a nucleoside phosphate.


name: purine ribonucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


name: nucleobase-containing small molecule metabolic process

description: The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.


name: T CELL RECEPTOR GAMMA CONSTANT 1-RELATED


name: NON-FUNCTIONAL T CELL RECEPTOR GAMMA VARIABLE-RELATED


name: T CELL RECEPTOR GAMMA VARIABLE 2-RELATED


name: T CELL RECEPTOR GAMMA VARIABLE 3-RELATED


name: NON-FUNCTIONAL T CELL RECEPTOR GAMMA VARIABLE 10-RELATED


name: MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM29


mitochondrial membrane

description: Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.


mitochondrial inner membrane

description: The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.


organelle inner membrane

description: The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.


mitochondrial envelope

description: The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.


name: inner mitochondrial membrane protein complex

description: Any protein complex that is part of the inner mitochondrial membrane.


description: A protein complex that is part of a mitochondrion.


name: protein insertion into mitochondrial inner membrane

description: The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane.


protein targeting to mitochondrion

description: The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.


mitochondrion organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.


protein targeting

description: The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.


protein localization to mitochondrion

description: A process in which a protein is transported to, or maintained in, a location within the mitochondrion.


name: inner mitochondrial membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane.


mitochondrial transport

description: Transport of substances into, out of or within a mitochondrion.


name: establishment of protein localization to mitochondrion

description: The directed movement of a protein to the mitochondrion or a part of the mitochondrion.


mitochondrial membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.


name: EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE  EIF2-ALPHA KINASE -RELATED


name: MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE


name: EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1


name: EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3


name: INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE


name: negative regulation of cell cycle process

description: Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.


name: regulation of cell cycle G2/M phase transition

description: Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle.


name: negative regulation of cell cycle G2/M phase transition

description: Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle.