name: neutral L-amino acid transmembrane transporter activity

description: Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3.


name: solute:proton symporter activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in).


name: glycine transmembrane transporter activity

description: Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid.


name: proton transmembrane transporter activity

description: Enables the transfer of a proton from one side of a membrane to the other.


name: aromatic amino acid transmembrane transporter activity

description: Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring.


name: basic amino acid transmembrane transporter activity

description: Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3.


name: amide transmembrane transporter activity

description: Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other.


L-amino acid transport

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


proton transmembrane transport

description: The directed movement of a proton across a membrane.


alanine transport

description: The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


glycine transport

description: The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


basic amino acid transport

description: The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: L-alpha-amino acid transmembrane transport

description: The directed movement of L-alpha-amino acid across a membrane by means of some agent such as a transporter or a pore.


name: ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN


name: CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL


name: CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL-RELATED


name: ETS TRANSLOCATION VARIANT 3-LIKE PROTEIN


name: ETS DOMAIN-CONTAINING TRANSCRIPTION FACTOR ERF-LIKE


name: ETS DOMAIN-CONTAINING TRANSCRIPTION FACTOR ERF


name: FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR


name: SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR


name: PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE-LIKE PROTEIN 1


name: PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE TYPE-1 GAMMA


name: PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE TYPE-2 BETA


name: PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE TYPE-1 BETA


name: PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE TYPE-2 ALPHA


name: PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE TYPE-2 GAMMA


name: PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE TYPE-1 ALPHA


lipid kinase activity

description: Catalysis of the phosphorylation of a simple or complex lipid.


name: LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 4


name: LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5


name: positive regulation of adenylate cyclase activity

description: Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.


name: positive regulation of Wnt signaling pathway

description: Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.


positive regulation of cyclase activity

description: Any process that activates or increases the activity of a cyclase.


name: regulation of canonical Wnt signaling pathway

description: Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


name: positive regulation of canonical Wnt signaling pathway

description: Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


regulation of Wnt signaling pathway

description: Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.


positive regulation of lyase activity

description: Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


reproductive system development

description: The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction.


reproductive structure development

description: The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.


male sex differentiation

description: The establishment of the sex of a male organism by physical differentiation.


sex differentiation

description: The establishment of the sex of an organism by physical differentiation.


male gonad development

description: The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.


name: PHOSPHATIDYLINOSITOL TRANSFER PROTEIN BETA ISOFORM


name: CYTOPLASMIC PHOSPHATIDYLINOSITOL TRANSFER PROTEIN 1


name: MEMBRANE-ASSOCIATED PHOSPHATIDYLINOSITOL TRANSFER PROTEIN 1


name: PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA ISOFORM


name: MEMBRANE-ASSOCIATED PHOSPHATIDYLINOSITOL TRANSFER PROTEIN 2


phosphatidylcholine binding

description: Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline.


description: Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.


phospholipid transporter activity

description: Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.


phosphatidylinositol binding

description: Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.


name: ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED


name: PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX


name: EEF1AKMT4-ECE2 READTHROUGH TRANSCRIPT PROTEIN-RELATED


hormone metabolic process

description: The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.


name: KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG


outer kinetochore

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The region of a kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.


name: SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1


post-mRNA release spliceosomal complex

description: A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac.


name: SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 1


name: STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 7


name: LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 2


name: LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 4


name: LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 1


name: LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 3


name: STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 11


name: SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 2


methylated histone binding

description: Binding to a histone in which a residue has been modified by methylation.


name: proton-transporting two-sector ATPase complex

description: A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.


name: TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2


name: TRANSFORMING ACIDIC COILED-COIL-CONTAINING PROTEIN 2


name: TRANSFORMING ACIDIC COILED-COIL-CONTAINING PROTEIN 1


name: TRANSFORMING ACIDIC COILED-COIL-CONTAINING PROTEIN 3


forebrain development

description: The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).


name: NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 1


name: NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 3


name: NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2


name: negative regulation of canonical NF-kappaB signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade.


name: BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1


osteoblast differentiation

description: The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.


name: SERINE_THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT


name: SERINE_THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM


name: SERINE_THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT


name: SERINE_THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM


name: protein serine/threonine phosphatase activity

description: Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.


name: THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2


name: THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2


name: METAL-RESPONSE ELEMENT-BINDING TRANSCRIPTION FACTOR 2


name: NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 2-RELATED


name: NEURON-SPECIFIC VESICULAR PROTEIN CALCYON


name: NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 1


name: NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 2


clathrin binding

description: Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.


name: CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL


name: CALCIUM UNIPORTER REGULATORY SUBUNIT MCUB, MITOCHONDRIAL


mitochondrial calcium ion homeostasis

description: Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.


name: APC MEMBRANE RECRUITMENT PROTEIN 2-RELATED


description: Binding to phosphatidylinositol bisphosphate.


description: Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.


phosphatidylinositol phosphate binding

description: Binding to phosphatidylinositol phosphate.


name: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3


name: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3


proteasome accessory complex

description: A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.


proteasome regulatory particle

description: A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex.


name: proteasome regulatory particle, lid subcomplex

description: The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.


proteasome complex

description: A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.


endopeptidase complex

description: A protein complex which is capable of endopeptidase activity.


COP9 signalosome

description: A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.


name: C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 8


protease binding

description: Binding to a protease or a peptidase.


complement activation

description: Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.


acrosomal membrane

description: The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.


acrosomal vesicle

description: A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.


secretory granule membrane

description: The lipid bilayer surrounding a secretory granule.


plasma membrane fusion

description: The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.


name: fusion of sperm to egg plasma membrane involved in single fertilization

description: The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.


plasma membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.


adenylyltransferase activity

description: Catalysis of the transfer of an adenylyl group to an acceptor.


response to virus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.


defense response to virus

description: Reactions triggered in response to the presence of a virus that act to protect the cell or organism.


inorganic anion transmembrane transport

description: The process in which an inorganic anion is transported across a membrane.


name: monoatomic anion transmembrane transport

description: The process in which a monoatomic anion is transported across a membrane. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom.


chloride transmembrane transport

description: The process in which chloride is transported across a membrane.


plasma membrane phospholipid scrambling

description: The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).


name: regulation of membrane lipid distribution

description: Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane.


phospholipid transport

description: The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.


lipid translocation

description: The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.


phospholipid translocation

description: The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.


name: water transmembrane transporter activity

description: Enables the transfer of water (H2O) from one side of a membrane to the other.


water transport

description: The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


fluid transport

description: The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


origin recognition complex

description: A multisubunit complex that is located at the replication origins of a chromosome.


nuclear chromosome

description: A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.


name: nuclear origin of replication recognition complex

description: A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.


DNA replication origin binding

description: Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.


DNA-templated DNA replication

description: A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.


DNA replication

description: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.


DNA replication initiation

description: The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 70


name: TRANSFORMING GROWTH FACTOR BETA ACTIVATOR LRRC33


name: STEROID TRANSMEMBRANE TRANSPORTER SLC22A24


name: SOLUTE CARRIER FAMILY 22 MEMBER 31-RELATED


name: organic cation transmembrane transporter activity

description: Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage.


organic cation transport

description: The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.


quaternary ammonium group transport

description: The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.


name: odontogenesis of dentin-containing tooth

description: The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.


odontogenesis

description: The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.


amelogenesis

description: The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage.


name: VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 8


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 6


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 4


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 3


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 5


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 7


voltage-gated potassium channel complex

description: A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.


name: delayed rectifier potassium channel activity

description: Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.


name: positive regulation of organelle organization

description: Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.


name: regulation of actin polymerization or depolymerization

description: Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.


name: regulation of protein-containing complex assembly

description: Any process that modulates the frequency, rate or extent of protein complex assembly.


regulation of protein polymerization

description: Any process that modulates the frequency, rate or extent of the process of creating protein polymers.


regulation of actin filament length

description: Any process that controls the length of actin filaments in a cell.


name: regulation of actin filament organization

description: Any process that modulates the frequency, rate or extent of actin filament organization.


name: positive regulation of protein polymerization

description: Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.


name: regulation of actin filament polymerization

description: Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.


transcription elongation factor complex

description: Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.


DNA-templated transcription elongation

description: The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.


name: transcription elongation by RNA polymerase II

description: The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3F


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3G


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3D


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3C


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3E


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3B


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3A


name: protein serine/threonine phosphatase complex

description: A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein.


name: regulation of calcium-mediated signaling

description: Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.


name: T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN


name: T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN-RELATED


name: NEURON-SPECIFIC CALCIUM-BINDING PROTEIN HIPPOCALCIN


name: MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30


mediator complex

description: A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.


name: NEUROPEPTIDE Y/PANCREATIC HORMONE/PEPTIDE YY


neuropeptide hormone activity

description: The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.


hormone activity

description: The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.


behavior

description: The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.


feeding behavior

description: Behavior associated with the intake of food.


name: ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A  ABCA


name: RETINAL-SPECIFIC PHOSPHOLIPID-TRANSPORTING ATPASE ABCA4


name: ABC-TYPE ORGANIC ANION TRANSPORTER ABCA8


name: ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 10


name: ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 6


name: ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 9


name: ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 13


name: ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2


name: ATPase-coupled intramembrane lipid transporter activity

description: Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases.


cargo receptor activity

description: Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles.


cholesterol transport

description: The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


cholesterol efflux

description: The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.


name: METHYL-CPG-BINDING DOMAIN PROTEIN 3-LIKE 1


name: METHYL-CPG-BINDING DOMAIN PROTEIN 3-LIKE 2-RELATED


name: DNA methylation-dependent heterochromatin formation

description: Repression of transcription by methylation of DNA, leading to the formation of heterochromatin.


name: microtubule polymerization or depolymerization

description: Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule.


microtubule polymerization

description: The addition of tubulin heterodimers to one or both ends of a microtubule.


microtubule nucleation

description: The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).


cytoplasmic microtubule organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.


regulation of hemopoiesis

description: Any process that modulates the frequency, rate or extent of hemopoiesis.


name: DOUBLE C2-LIKE DOMAIN-CONTAINING PROTEIN ALPHA


name: DOUBLE C2-LIKE DOMAIN-CONTAINING PROTEIN BETA


name: HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL


lipid oxidation

description: The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.


fatty acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.


organic acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.


fatty acid beta-oxidation

description: A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).


carboxylic acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.


monocarboxylic acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group.


name: RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39


name: POTE ANKYRIN DOMAIN FAMILY MEMBER B-RELATED


name: POTE ANKYRIN DOMAIN FAMILY MEMBER G-RELATED


name: COILED-COIL DOMAIN-CONTAINING PROTEIN 180


name: ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 6


name: ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 5


name: ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8


name: ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 10


name: ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 12


name: MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1


name: ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 2


name: ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 4


name: ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 3


name: CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR


name: ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 11


name: ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 9


name: oligopeptide transmembrane transporter activity

description: Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


name: peptide transmembrane transporter activity

description: Enables the transfer of a peptide from one side of a membrane to the other.


amide transport

description: The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


oligopeptide transport

description: The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


oligopeptide transmembrane transport

description: The process in which an oligopeptide is transported across a membrane. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


peptide transport

description: The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20


name: MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 HOMOLOG


name: mitochondrial outer membrane translocase complex

description: A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments.


name: protein transmembrane transporter activity

description: Enables the transfer of a protein from one side of a membrane to the other.


name: protein import into mitochondrial matrix

description: The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.


name: FIBRINOGEN C DOMAIN-CONTAINING PROTEIN 1


protein tyrosine kinase binding

description: Binding to protein tyrosine kinase.


receptor tyrosine kinase binding

description: Binding to a receptor that possesses protein tyrosine kinase activity.


triglyceride homeostasis

description: Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell.


regulation of lipase activity

description: Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.


regulation of phospholipase activity

description: Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.


cholesterol homeostasis

description: Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.


lipid homeostasis

description: Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.


growth

description: The increase in size or mass of an entire organism, a part of an organism or a cell.


neuron projection extension

description: Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.


developmental cell growth

description: The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.


name: developmental growth involved in morphogenesis

description: The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape.


developmental growth

description: The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.


cell growth

description: The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.


homotypic cell-cell adhesion

description: The attachment of a cell to a second cell of the identical type via adhesion molecules.


protein activation cascade

description: A sequential series of modifications to a set of proteins where the product of one reaction catalyzes the following reaction, ultimately leading to the generation of a mature protein. Modifications typically include proteolysis or covalent modification, and may also include binding events.


platelet aggregation

description: The adhesion of one platelet to one or more other platelets via adhesion molecules.


name: RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3


name: RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2


name: RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1


name: RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 2


name: CELL DIVISION CONTROL PROTEIN 42 HOMOLOG


name: RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 1


Rac protein signal transduction

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An intracellular signaling cassette in which a small monomeric GTPase of the Rac subfamily relays a signal.


name: contractile actin filament bundle assembly

description: Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle.


stress fiber assembly

description: The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.


actin filament bundle assembly

description: The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.


actin filament bundle organization

description: A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.


name: SYNAPSE DIFFERENTIATION-INDUCING GENE PROTEIN 1


name: SYNAPSE DIFFERENTIATION-INDUCING GENE PROTEIN 1-LIKE


postsynaptic density membrane

description: The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.


name: ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER


name: ACTIN FILAMENT-ASSOCIATED PROTEIN 1-LIKE 2


name: ACTIN FILAMENT-ASSOCIATED PROTEIN 1-LIKE 1


SH3 domain binding

description: Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.


name: regulation of epidermal growth factor receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.


regulation of ERBB signaling pathway

description: Any process that modulates the frequency, rate or extent of ERBB signaling pathway.


name: PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2  MPV17


name: EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7


name: EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D


name: eukaryotic translation initiation factor 3 complex

description: A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.


name: RIBONUCLEASE P PROTEIN SUBUNIT P25-LIKE PROTEIN


endoribonuclease complex

description: A protein complex which is capable of endoribonuclease activity.


ribonuclease MRP complex

description: A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.


endonuclease complex

description: A protein complex which is capable of endonuclease activity.


name: ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL


name: PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY D MEMBER 1


name: DIFFERENTIALLY EXPRESSED IN FDCP 6 HOMOLOG


name: P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR


secondary metabolic process

description: The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.


name: CLATHRIN BINDING BOX OF AFTIPHILIN CONTAINING 1


trans-Golgi network membrane

description: The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.


clathrin vesicle coat

description: A clathrin coat found on a vesicle.


AP-type membrane coat adaptor complex

description: Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa).


90S preribosome

description: A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.


name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.


maturation of SSU-rRNA

description: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY S MEMBER 2


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 1


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY F MEMBER 1


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY C MEMBER 3


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY V MEMBER 1


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 6


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY C MEMBER 4


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 3


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY G MEMBER 1


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 7


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY S MEMBER 1


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 10


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 3


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY S MEMBER 3


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 4


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY C MEMBER 1


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY V MEMBER 2


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY B MEMBER 2


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 2


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY B MEMBER 1


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY C MEMBER 2


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 1


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 5


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY G MEMBER 3


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY G MEMBER 2


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY G MEMBER 4


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2


name: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 2


main axon

description: The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites.


name: Muscarinic acetylcholine receptor 1 and 3 signaling pathway


name: PLATELET-DERIVED GROWTH FACTOR SUBUNIT A


name: PLATELET-DERIVED GROWTH FACTOR SUBUNIT B


ERBB signaling pathway

description: The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: positive regulation of cytokine-mediated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.


name: GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT 1


sugar-phosphatase activity

description: Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.


monosaccharide metabolic process

description: The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.


glucose metabolic process

description: The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.


glucose 6-phosphate metabolic process

description: The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6.


hexose biosynthetic process

description: The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.


hexose metabolic process

description: The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.


name: CARBONIC ANHYDRASE 5B, MITOCHONDRIAL-RELATED


carbon-oxygen lyase activity

description: Catalysis of the breakage of a carbon-oxygen bond.


lyase activity

description: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.


hydro-lyase activity

description: Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.


name: INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1


wide pore channel activity

description: Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.


name: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

description: Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.


apoptotic mitochondrial changes

description: The morphological and physiological alterations undergone by mitochondria during apoptosis.


name: activation of cysteine-type endopeptidase activity involved in apoptotic process

description: Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.


name: regulation of cysteine-type endopeptidase activity involved in apoptotic process

description: Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis.


name: release of cytochrome c from mitochondria

description: The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.


mitochondrial fusion

description: Merging of two or more mitochondria within a cell to form a single compartment.


signaling adaptor activity

description: The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.


name: WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 3


name: WD REPEAT- AND FYVE DOMAIN-CONTAINING PROTEIN 4


name: cyclin-dependent protein kinase holoenzyme complex

description: Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.


name: regulation of cyclin-dependent protein serine/threonine kinase activity

description: Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.


positive regulation of cell cycle

description: Any process that activates or increases the rate or extent of progression through the cell cycle.


name: positive regulation of cell cycle G1/S phase transition

description: Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.


name: positive regulation of cell cycle process

description: Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.


name: positive regulation of mitotic cell cycle

description: Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.


name: regulation of G1/S transition of mitotic cell cycle

description: Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.


name: regulation of cell cycle G1/S phase transition

description: Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.


name: establishment of chromosome localization

description: The directed movement of a chromosome to a specific location.


mitotic metaphase chromosome alignment

description: A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division.


chromosome localization

description: Any process in which a chromosome is transported to, or maintained in, a specific location.


metaphase chromosome alignment

description: A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division.


actin filament

description: A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.


axonal growth cone

description: The migrating motile tip of a growing nerve cell axon.


growth cone

description: The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.


site of polarized growth

description: Any part of a cell where non-isotropic growth takes place.


ruffle

description: Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.


microfilament motor activity

description: A motor activity that generates movement along a microfilament, driven by ATP hydrolysis.


name: establishment or maintenance of epithelial cell apical/basal polarity

description: Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.


tissue morphogenesis

description: The process in which the anatomical structures of a tissue are generated and organized.


name: establishment or maintenance of apical/basal cell polarity

description: Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components.


morphogenesis of an epithelium

description: The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.


name: establishment or maintenance of bipolar cell polarity

description: Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns.


name: GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 1-RELATED


name: GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 10-RELATED


name: GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 2


name: GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 7


N-acyltransferase activity

description: Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.


name: POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 1


name: POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4


name: POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 2


name: POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 3


regulation of membrane depolarization

description: Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.


name: CILIOGENESIS AND PLANAR POLARITY EFFECTOR 2


name: NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED


name: CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2


name: CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1


iron-sulfur cluster binding

description: Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.


iron-sulfur cluster assembly

description: The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.


name: ATP SYNTHASE COUPLING FACTOR 6, MITOCHONDRIAL


name: ATP SYNTHASE-COUPLING FACTOR 6, MITOCHONDRIAL


name: mitochondrial proton-transporting ATP synthase complex

description: A proton-transporting ATP synthase complex found in the mitochondrial membrane.


name: proton-transporting ATP synthase complex

description: A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient.


name: CYTOSOLIC CARBOXYPEPTIDASE-LIKE PROTEIN 5


name: APOLIPOPROTEIN L DOMAIN-CONTAINING PROTEIN 1


name: regulation of epithelial cell differentiation

description: Any process that modulates the frequency, rate or extent of epithelial cell differentiation.


name: 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING], MITOCHONDRIAL


name: oxidoreductase activity, acting on the CH-CH group of donors

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


name: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.


name: SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL


oxidoreductase complex

description: Any protein complex that possesses oxidoreductase activity.


name: LYSOSOMAL ACID LIPASE_CHOLESTERYL ESTER HYDROLASE


triglyceride lipase activity

description: Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.


name: SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT


name: SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-2


name: POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA


name: SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-3


name: SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1


nuclear membrane

description: Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.


nuclear inner membrane

description: The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.


ATPase activator activity

description: Binds to and increases the activity of an ATP hydrolysis activity.


sodium ion homeostasis

description: Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell.


name: potassium ion import across plasma membrane

description: The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.


name: FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2


name: FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1


name: positive regulation of leukocyte migration

description: Any process that activates or increases the frequency, rate, or extent of leukocyte migration.


mononuclear cell migration

description: The movement of a mononuclear cell within or between different tissues and organs of the body.


lymphocyte migration

description: The movement of a lymphocyte within or between different tissues and organs of the body.


name: SODIUM- AND CHLORIDE-DEPENDENT NEUTRAL AND BASIC AMINO ACID TRANSPORTER B(0+)


name: SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER XTRP3


name: SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT1


name: SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 3


name: SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT2


name: SODIUM- AND CHLORIDE-DEPENDENT TAURINE TRANSPORTER


name: INACTIVE SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT3


name: SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER


name: ORPHAN SODIUM- AND CHLORIDE-DEPENDENT NEUROTRANSMITTER TRANSPORTER NTT5


name: SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 1


name: SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 2


name: SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 2


name: SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER SLC6A17


name: SODIUM- AND CHLORIDE-DEPENDENT CREATINE TRANSPORTER 1


name: SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 1


name: Adrenaline and noradrenaline biosynthesis


name: 5HT3 type receptor mediated signaling pathway


organic acid:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in).


name: solute:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in).


amino acid:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in).


name: branched-chain amino acid transmembrane transporter activity

description: Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings.


name: secondary active monocarboxylate transmembrane transporter activity

description: Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism.


name: monocarboxylic acid transmembrane transporter activity

description: Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group.


name: amino acid import across plasma membrane

description: The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol.


L-leucine transport

description: The directed movement of L-leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


branched-chain amino acid transport

description: The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings.


name: SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS


regulation of cell size

description: Any process that modulates the size of a cell.


cortical cytoskeleton

description: The portion of the cytoskeleton that lies just beneath the plasma membrane.


name: negative regulation of protein polymerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers.


name: negative regulation of protein depolymerization

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization.


name: negative regulation of actin filament depolymerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.


name: negative regulation of organelle organization

description: Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.


barbed-end actin filament capping

description: The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.


name: negative regulation of supramolecular fiber organization

description: Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization.


name: regulation of actin filament depolymerization

description: Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament.


name: negative regulation of actin filament polymerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.


name: negative regulation of protein-containing complex assembly

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.


name: negative regulation of cytoskeleton organization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.


peptide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.


sulfur compound catabolic process

description: The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.


name: PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE


name: EPIDIDYMAL SECRETORY GLUTATHIONE PEROXIDASE


response to oxidative stress

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


response to reactive oxygen species

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.


name: PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE


acetylglucosaminyltransferase activity

description: Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar.


intramolecular transferase activity

description: Catalysis of the transfer of a functional group from one position to another within a single molecule.


mRNA modification

description: The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.


pseudouridine synthesis

description: The intramolecular conversion of uridine to pseudouridine within an RNA molecule.


name: ACETYLCHOLINESTERASE COLLAGENIC TAIL PEPTIDE


collagen trimer

description: A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.


kidney development

description: The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.


cartilage development

description: The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


name: T CELL RECEPTOR ALPHA VARIABLE 23_DELTA VARIABLE 6


name: T CELL RECEPTOR ALPHA VARIABLE 29_DELTA VARIABLE 5


name: MONOCYTE TO MACROPHAGE DIFFERENTIATION FACTOR 2


name: PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3


name: MONOCYTE TO MACROPHAGE DIFFERENTIATION FACTOR


name: PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 4


response to steroid hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.


name: OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL


name: OCCLUDIN_ELL DOMAIN-CONTAINING PROTEIN 1


name: RNA POLYMERASE II ELONGATION FACTOR ELL2


name: RNA POLYMERASE II ELONGATION FACTOR ELL3


name: regulation of transcription elongation by RNA polymerase II

description: Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.


name: positive regulation of DNA-templated transcription, elongation

description: Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.


name: positive regulation of transcription elongation by RNA polymerase II

description: Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.


name: regulation of DNA-templated transcription elongation

description: Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.


snRNA metabolic process

description: The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein.


name: snRNA transcription by RNA polymerase II

description: The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.


immunoglobulin mediated immune response

description: An immune response mediated by immunoglobulins, whether cell-bound or in solution.


leukocyte mediated immunity

description: Any process involved in the carrying out of an immune response by a leukocyte.


lymphocyte mediated immunity

description: Any process involved in the carrying out of an immune response by a lymphocyte.


name: ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2


name: ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1


name: ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3


name: FIBROBLAST GROWTH FACTOR-BINDING PROTEIN 1


name: FIBROBLAST GROWTH FACTOR-BINDING PROTEIN 2


name: FIBROBLAST GROWTH FACTOR-BINDING PROTEIN 3


name: SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 10


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 46


name: KINASE NON-CATALYTIC C-LOBE DOMAIN-CONTAINING PROTEIN 1


regulation of dendrite development

description: Any process that modulates the frequency, rate or extent of dendrite development.


name: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 25


name: MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED


name: REGENERATING ISLET-DERIVED PROTEIN 3-ALPHA


name: REGENERATING ISLET-DERIVED PROTEIN 3-GAMMA


peptidoglycan binding

description: Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.


oligosaccharide binding

description: Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.


name: IG-LIKE V-TYPE DOMAIN-CONTAINING PROTEIN FAM187A


name: DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1


name: folic acid-containing compound metabolic process

description: The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.


name: homophilic cell adhesion via plasma membrane adhesion molecules

description: The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.


cell recognition

description: The process in which a cell in an organism interprets its surroundings.


name: negative regulation of protein phosphorylation

description: Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.


name: negative regulation of phosphorus metabolic process

description: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.


negative regulation of phosphorylation

description: Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.


name: negative regulation of phosphate metabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.


name: RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 3


name: PROTO-ONCOGENE SERINE_THREONINE-PROTEIN KINASE MOS


name: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 21


Ras protein signal transduction

description: An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal.


name: PSEUDOURIDYLATE SYNTHASE TRUB2, MITOCHONDRIAL


name: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3


name: DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1


RNA polymerase III complex

description: RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.


RNA polymerase I complex

description: RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.


5'-3' RNA polymerase activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end.


name: DNA-directed 5'-3' RNA polymerase activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


RNA polymerase activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template.


RNA polymerase III activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


RNA polymerase I activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


non-canonical Wnt signaling pathway

description: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via effectors other than beta-catenin.


canonical Wnt signaling pathway

description: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.


Wnt signaling pathway

description: The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state.


smoothened signaling pathway

description: The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.


extracellular matrix binding

description: Binding to a component of the extracellular matrix.


name: ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 17-RELATED


name: ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 5C-RELATED


protein localization to Golgi apparatus

description: A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.


protein localization to cilium

description: A process in which a protein is transported to, or maintained in, a location within a cilium.


name: THYMOCYTE SELECTION-ASSOCIATED HIGH MOBILITY GROUP BOX PROTEIN TOX


name: TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 3


name: TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 2


name: TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 4


name: endoplasmic reticulum tubular network organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section.


name: RNA-BINDING MOTIF, SINGLE-STRANDED-INTERACTING PROTEIN 1


name: RNA-BINDING MOTIF, SINGLE-STRANDED-INTERACTING PROTEIN 3


name: RNA-BINDING MOTIF, SINGLE-STRANDED-INTERACTING PROTEIN 2


single-stranded RNA binding

description: Binding to single-stranded RNA.


poly(A) binding

description: Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.


mRNA splice site recognition

description: Selection of a splice site by components of the assembling spliceosome.


spliceosomal complex assembly

description: The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.


name: regulation of alternative mRNA splicing, via spliceosome

description: Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.


name: EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED


name: BMP-BINDING ENDOTHELIAL REGULATOR PROTEIN


ruffle membrane

description: The portion of the plasma membrane surrounding a ruffle.


high-density lipoprotein particle

description: A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.


name: LEUCINE-RICH GLIOMA-INACTIVATED PROTEIN 1


peripheral nervous system development

description: The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.


gliogenesis

description: The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.


glial cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.


name: NEURAL RETINA-SPECIFIC LEUCINE ZIPPER PROTEIN


name: MYOSIN LIGHT CHAIN 1_3, SKELETAL MUSCLE ISOFORM


myosin complex

description: A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.


structural constituent of muscle

description: The action of a molecule that contributes to the structural integrity of a muscle fiber.


exocyst

description: A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.


Golgi to plasma membrane transport

description: The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.


name: WAS_WASL-INTERACTING PROTEIN FAMILY MEMBER 3


alpha-tubulin binding

description: Binding to the microtubule constituent protein alpha-tubulin.


name: Arp2/3 complex-mediated actin nucleation

description: The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.


name: SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 75A


name: MELANOMA ANTIGEN PREFERENTIALLY EXPRESSED IN TUMORS


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 14B


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 14


name: ENDOTHELIAL CELL-SELECTIVE ADHESION MOLECULE


cell-cell adhesion mediator activity

description: The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell.


name: LEUCINE-RICH REPEAT, IMMUNOGLOBULIN-LIKE DOMAIN AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 3


name: LEUCINE-RICH REPEAT, IMMUNOGLOBULIN-LIKE DOMAIN AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2


name: LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 1


name: LEUCINE-RICH REPEAT, IMMUNOGLOBULIN-LIKE DOMAIN AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1


name: LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 4


name: LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 2


name: LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 3


name: LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 5


name: ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED


name: ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL


name: SKI FAMILY TRANSCRIPTIONAL COREPRESSOR 2


name: SKI FAMILY TRANSCRIPTIONAL COREPRESSOR 1


SMAD binding

description: Binding to a SMAD signaling protein.


name: LEUCINE RICH REPEAT  IN FLII  INTERACTING PROTEIN


name: LEUCINE-RICH REPEAT FLIGHTLESS-INTERACTING PROTEIN 2


name: LEUCINE-RICH REPEAT FLIGHTLESS-INTERACTING PROTEIN 1


name: TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL


postreplication repair

description: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication.


translesion synthesis

description: The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.


DNA biosynthetic process

description: The biosynthetic process resulting in the formation of DNA.


DNA synthesis involved in DNA repair

description: Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.


name: proteinogenic amino acid metabolic process

description: The chemical reactions and pathways involving any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.


alpha-amino acid metabolic process

description: The chemical reactions and pathways involving an alpha-amino acid.


name: aspartate family amino acid metabolic process

description: The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.


L-amino acid metabolic process

description: The chemical reactions and pathways involving an L-amino acid.


amino acid metabolic process

description: The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.


name: EPITHELIAL SPLICING REGULATORY PROTEIN 1


name: HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN H3


name: HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN H2


name: HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN F


name: EPITHELIAL SPLICING REGULATORY PROTEIN 2


name: HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN H


membrane assembly

description: The aggregation, arrangement and bonding together of a set of components to form a membrane.


Golgi organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.


name: WD REPEAT AND COILED-COIL-CONTAINING PROTEIN


name: H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3


name: T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED


name: T CELL RECEPTOR ALPHA VARIABLE 17-RELATED


name: T CELL RECEPTOR ALPHA VARIABLE 36_DELTA VARIABLE 7


name: T CELL RECEPTOR ALPHA VARIABLE 20-RELATED


name: T CELL RECEPTOR ALPHA VARIABLE 1-1-RELATED


name: T CELL RECEPTOR ALPHA CHAIN MC.7.G5-RELATED


name: regulation of cellular response to stress

description: Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


name: regulation of double-strand break repair

description: Any process that modulates the frequency, rate or extent of double-strand break repair.


regulation of DNA repair

description: Any process that modulates the frequency, rate or extent of DNA repair.


name: TRAF-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN 1


name: negative regulation of innate immune response

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.


name: MAP_MICROTUBULE AFFINITY-REGULATING KINASE 4


name: PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE


name: HORMONALLY UP-REGULATED NEU TUMOR-ASSOCIATED KINASE


name: CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 1


name: MAP_MICROTUBULE AFFINITY-REGULATING KINASE 3


name: ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5


name: ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4


name: ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 7


fucosyltransferase activity

description: Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


name: DYNEIN HEAVY CHAIN DOMAIN-CONTAINING PROTEIN 1


inner dynein arm

description: Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.


axonemal dynein complex

description: A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.


motile cilium

description: A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.


9+2 motile cilium

description: A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).


dynein complex

description: Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.


cytoplasmic dynein complex

description: Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.


outer dynein arm

description: Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.


sperm flagellum

description: A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.


cilium-dependent cell motility

description: Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.


name: cilium or flagellum-dependent cell motility

description: Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.


name: cilium movement involved in cell motility

description: Movement of cilia mediated by motor proteins that contributes to the movement of a cell.


cilium movement

description: The directed, self-propelled movement of a cilium.


intraciliary retrograde transport

description: The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins.


intraciliary transport

description: The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.


outer dynein arm assembly

description: The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.


axonemal dynein complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.


name: SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT BETA


rough endoplasmic reticulum membrane

description: The lipid bilayer surrounding the rough endoplasmic reticulum.