lens development in camera-type eye

description: The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.


name: TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1


name: DIVALENT CATION TRANSPORTER  SOLUTE CARRIER FAMILY 41


name: TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE


name: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.


spindle microtubule

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.


mitotic spindle

description: A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.


spindle

description: The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.


cytoskeletal motor activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).


microtubule motor activity

description: A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.


name: plus-end-directed microtubule motor activity

description: A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis.


spindle elongation

description: The cell cycle process in which the distance is lengthened between poles of the spindle.


name: ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED


maturation of 5.8S rRNA

description: Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule.


O-acyltransferase activity

description: Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.


name: NUCLEOPORIN P58/P45  NUCLEOPORIN-LIKE PROTEIN 1


nuclear pore

description: A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.


signal sequence binding

description: Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.


structural constituent of nuclear pore

description: The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.


name: DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT


oligosaccharyltransferase complex

description: A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected.


protein N-linked glycosylation

description: A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.


name: protein N-linked glycosylation via asparagine

description: The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.


thiosulfate sulfurtransferase activity

description: Catalysis of the reaction: hydrogen cyanide + thiosulfate = H+ + sulfite + thiocyanate.


sulfurtransferase activity

description: Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).


name: PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN


name: PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 2 PROTEIN


name: DEP DOMAIN-CONTAINING MTOR-INTERACTING PROTEIN


regulation of BMP signaling pathway

description: Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.


name: regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

description: Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.


name: negative regulation of BMP signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-2


name: GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-12


name: GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-13


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) SUBUNIT ALPHA ISOFORMS XLAS


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(OLF) SUBUNIT ALPHA


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1


name: GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-3


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(Z) SUBUNIT ALPHA


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(O) SUBUNIT ALPHA


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-1


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-3


name: GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-2


photoreceptor inner segment

description: The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.


brush border

description: The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.


cluster of actin-based cell projections

description: A cell part consisting of multiple, closely packed actin-based cell projections.


name: Muscarinic acetylcholine receptor 2 and 4 signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: 5HT1 type receptor mediated signaling pathway


dopamine receptor binding

description: Binding to a dopamine receptor.


hormone receptor binding

description: Binding to a receptor for a hormone.


name: detection of chemical stimulus involved in sensory perception of bitter taste

description: The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.


name: detection of chemical stimulus involved in sensory perception of taste

description: The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal.


sensory perception of taste

description: The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.


sensory perception of bitter taste

description: The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


Rho protein signal transduction

description: An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal.


name: G protein-coupled dopamine receptor signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by a dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


response to light stimulus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.


response to radiation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.


name: AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT ALPHA


name: AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT BETA


name: AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT DELTA


name: AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA


name: ligand-gated monoatomic ion channel activity

description: Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.


name: ligand-gated monoatomic cation channel activity

description: Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.


ligand-gated channel activity

description: Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.


name: DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED PROTEIN 2


name: DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED PROTEIN 4


name: ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6


name: ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 8


name: ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 6


name: ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 4


name: ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 5


centriole

description: A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.


name: TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN


name: BAG FAMILY MOLECULAR CHAPERONE REGULATOR 3


name: BAG FAMILY MOLECULAR CHAPERONE REGULATOR 5


name: BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1


name: BAG FAMILY MOLECULAR CHAPERONE REGULATOR 4


name: negative regulation of protein modification process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


name: negative regulation of protein ubiquitination

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.


name: CYTOSOLIC 5'-NUCLEOTIDASE 1 FAMILY MEMBER


5'-nucleotidase activity

description: Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.


nucleotidase activity

description: Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.


nucleoside metabolic process

description: The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine).


purine nucleoside metabolic process

description: The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).


adenosine metabolic process

description: The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.


glycosyl compound metabolic process

description: The chemical reactions and pathways involving glycosyl compound.


name: NK1 TRANSCRIPTION FACTOR-RELATED PROTEIN 1


name: NK1 TRANSCRIPTION FACTOR-RELATED PROTEIN 2


name: NUCLEAR PORE COMPLEX INTERACTING PROTEIN


name: NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER A2-RELATED


name: NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER B15-RELATED


name: NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER A1-RELATED


name: SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52


name: VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG


post-Golgi vesicle-mediated transport

description: The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.


Golgi to vacuole transport

description: The directed movement of substances from the Golgi to the vacuole.


name: ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 20A1-RELATED


name: ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 18B


name: ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 30A


name: ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 26-RELATED


name: ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 36A-RELATED


name: ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 19-RELATED


name: ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 62


name: ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 30B


name: ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 7


name: ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 36C


name: ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 18A


name: PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX32-RELATED


name: ATP-DEPENDENT RNA HELICASE DHX35-RELATED


name: ATP-DEPENDENT RNA HELICASE DHX57-RELATED


name: ATP-DEPENDENT RNA HELICASE DHX37-RELATED


name: PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16


name: ATP-DEPENDENT RNA HELICASE DHX34-RELATED


name: PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16


name: ATP-DEPENDENT RNA HELICASE DHX40-RELATED


helicase activity

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.


ATP-dependent activity, acting on DNA

description: Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.


DNA helicase activity

description: Unwinding of a DNA helix, driven by ATP hydrolysis.


name: positive regulation of transcription by RNA polymerase I

description: Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.


protein-RNA complex organization

description: Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex.


antioxidant activity

description: Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.


tetrapyrrole binding

description: Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position.


name: oxidoreductase activity, acting on peroxide as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor.


heme binding

description: Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.


name: PROTEIN DISULFIDE-ISOMERASE-LIKE PROTEIN OF THE TESTIS


name: ENDOPLASMIC RETICULUM RESIDENT PROTEIN 27


protein disulfide isomerase activity

description: Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.


name: ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED


name: ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE


name: primary active transmembrane transporter activity

description: Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical such as ATP hydrolysis, redox energy and photon energy.


name: ATPase-coupled monoatomic cation transmembrane transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).


P-type ion transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate.


name: ATPase-coupled transmembrane transporter activity

description: Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.


vesicle fusion

description: Fusion of the membrane of a transport vesicle with its target membrane.


organelle membrane fusion

description: The joining of two lipid bilayers to form a single organelle membrane.


organelle fusion

description: The creation of a single organelle from two or more organelles.


regulation of cellular component size

description: A process that modulates the size of a cellular component.


membrane fusion

description: The membrane organization process that joins two lipid bilayers to form a single membrane.


name: HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR


name: TRACE AMINE-ASSOCIATED RECEPTOR 3-RELATED


post-embryonic development

description: The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.


name: positive regulation of cysteine-type endopeptidase activity

description: Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity.


name: regulation of cysteine-type endopeptidase activity

description: Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity.


positive regulation of proteolysis

description: Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.


name: positive regulation of peptidase activity

description: Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.


zymogen activation

description: The proteolytic processing of an inactive enzyme to an active form.


name: positive regulation of endopeptidase activity

description: Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.


name: U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN


name: basal RNA polymerase II transcription machinery binding

description: Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.


RNA polymerase binding

description: Binding to an RNA polymerase molecule or complex.


RNA polymerase core enzyme binding

description: Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme.


RNA polymerase II complex binding

description: Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.


basal transcription machinery binding

description: Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.


name: negative regulation of protein-containing complex disassembly

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.


name: negative regulation of cellular component organization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.


canonical NF-kappaB signal transduction

description: An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs).


name: non-canonical NF-kappaB signal transduction

description: An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF).


name: DNA-binding transcription factor binding

description: Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.


name: TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED


name: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 18


name: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 12


name: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 22


protein tyrosine phosphatase activity

description: Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


phosphoprotein phosphatase activity

description: Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.


protein dephosphorylation

description: The process of removing one or more phosphoric residues from a protein.


sarcoplasmic reticulum

description: A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.


regulation of synaptic plasticity

description: A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.


name: TRANSCRIPTION FACTOR SPT20 HOMOLOG-LIKE 2-RELATED


name: TRANSCRIPTION FACTOR SPT20 HOMOLOG-LIKE 1


SAGA-type complex

description: A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs).


peptidase complex

description: A protein complex which is capable of peptidase activity.


histone acetyltransferase complex

description: A protein complex that possesses histone acetyltransferase activity.


acetyltransferase complex

description: A protein complex which is capable of acetyltransferase activity.


protein acetyltransferase complex

description: A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule.


SAGA complex

description: A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695).


centrosome

description: A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.


ribosomal subunit export from nucleus

description: The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.


ribosomal large subunit biogenesis

description: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.


regulation of centrosome duplication

description: Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.


regulation of centrosome cycle

description: Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation.


ribosomal small subunit biogenesis

description: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.


name: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA


name: NUCLEAR RECEPTOR SUBFAMILY 1 GROUP D MEMBER 1


name: NUCLEAR RECEPTOR SUBFAMILY 1 GROUP D MEMBER 2


name: NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2


name: NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 3


name: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA


name: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA


hormone-mediated signaling pathway

description: The series of molecular signals mediated by the detection of a hormone.


name: intracellular receptor signaling pathway

description: The series of molecular signals initiated by a ligand binding to a receptor located within a cell.


name: MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED


name: GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 3


name: MICROTUBULE-ASSOCIATED PROTEINS 1A_1B LIGHT CHAIN 3C


name: GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 2


name: MICROTUBULE-ASSOCIATED PROTEINS 1A_1B LIGHT CHAIN 3 BETA 2-RELATED


name: GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1


name: GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN


name: MICROTUBULE-ASSOCIATED PROTEINS 1A_1B LIGHT CHAIN 3A


autophagosome membrane

description: The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.


autophagosome

description: A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.


ubiquitin-like protein ligase binding

description: Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase.


ubiquitin protein ligase binding

description: Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.


GABA receptor binding

description: Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.


cellular response to starvation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.


cellular response to nutrient levels

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.


response to starvation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.


cellular response to external stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.


name: STRIATED MUSCLE PREFERENTIALLY EXPRESSED PROTEIN KINASE


name: MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE


serine-type endopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


serine hydrolase activity

description: Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


name: SPERMATOGENESIS-ASSOCIATED PROTEIN 6 SPATA6


name: SPERMATOGENESIS ASSOCIATED 6-LIKE PROTEIN


name: NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR


name: GONADOTROPIN-RELEASING HORMONE II RECEPTOR-RELATED


name: PYROGLUTAMYLATED RF-AMIDE PEPTIDE RECEPTOR


name: Oxytocin receptor mediated signaling pathway


peptide receptor activity

description: Combining with an extracellular or intracellular peptide to initiate a change in cell activity.


name: G protein-coupled peptide receptor activity

description: Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


circadian rhythm

description: Any biological process in an organism that recurs with a regularity of approximately 24 hours.


rhythmic process

description: Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.


regulation of hormone levels

description: Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.


regulation of hormone secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.


name: regulation of systemic arterial blood pressure

description: The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.


neuropeptide signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


name: CANCER_TESTIS ANTIGEN FAMILY 47 MEMBER C1


name: CANCER_TESTIS ANTIGEN FAMILY 47 MEMBER B1


unfolded protein binding

description: Binding to an unfolded protein.


chaperone-mediated protein folding

description: The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.


name: EWING'S TUMOR-ASSOCIATED ANTIGEN 1 ETAA1


name: ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3


name: ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1


name: ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2


ATP binding

description: Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.


name: TRANSCRIPTION INITIATION FACTOR IIB-RELATED


name: TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT


name: TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT


name: Transcription regulation by bZIP transcription factor


name: core promoter sequence-specific DNA binding

description: Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.


TBP-class protein binding

description: Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).


transcription by RNA polymerase III

description: The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.


protein acetylation

description: The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


name: C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 1


name: C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 2


name: COILED-COIL DOMAIN-CONTAINING PROTEIN 189


name: CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 119


name: CILIARY-ASSOCIATED CALCIUM-BINDING COILED-COIL PROTEIN 1


name: GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN


transcription export complex 2

description: A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p.


mRNA export from nucleus

description: The directed movement of mRNA from the nucleus to the cytoplasm.


establishment of RNA localization

description: The directed movement of RNA to a specific location.


nucleic acid transport

description: The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


mRNA transport

description: The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


RNA localization

description: A process in which RNA is transported to, or maintained in, a specific location.


RNA transport

description: The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


RNA export from nucleus

description: The directed movement of RNA from the nucleus to the cytoplasm.


centrosome cycle

description: The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.


centrosome duplication

description: The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.


name: TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 3


name: PANCREATIC SECRETORY GRANULE MEMBRANE MAJOR GLYCOPROTEIN GP2


name: ONCOPROTEIN-INDUCED TRANSCRIPT 3 PROTEIN


name: ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1


name: CUB AND ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1


name: TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE 3-LIKE PROTEIN


glycosaminoglycan binding

description: Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues.


name: transmembrane receptor protein serine/threonine kinase activity

description: Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.


name: extracellular matrix structural constituent

description: The action of a molecule that contributes to the structural integrity of the extracellular matrix.


name: regulation of transforming growth factor beta receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.


name: THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1


name: THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1


name: MITOCHONDRIAL GLUTATHIONE TRANSPORTER SLC25A39-RELATED


name: MITOCHONDRIAL GLUTATHIONE TRANSPORTER SLC25A40-RELATED


name: ENDOGENOUS RETROVIRUS GROUP K MEMBER 113 ENV POLYPROTEIN-RELATED


name: EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR GTP-BINDING SUBUNIT ERF3A


name: EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR GTP-BINDING SUBUNIT ERF3B


translation elongation factor activity

description: Functions in chain elongation during polypeptide synthesis at the ribosome.


translational elongation

description: The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.


name: VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 1


name: VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 2


description: An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.


basement membrane

description: A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.


endoderm formation

description: The formation of the endoderm during gastrulation.


formation of primary germ layer

description: The formation of the ectoderm, mesoderm and endoderm during gastrulation.


endoderm development

description: The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.


gastrulation

description: A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.


cell-matrix adhesion

description: The binding of a cell to the extracellular matrix via adhesion molecules.


cell-substrate adhesion

description: The attachment of a cell to the underlying substrate via adhesion molecules.


DNA N-glycosylase activity

description: Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.


base-excision repair

description: In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.


regulation of cell shape

description: Any process that modulates the surface configuration of a cell.


positive regulation of axonogenesis

description: Any process that activates or increases the frequency, rate or extent of axonogenesis.


regulation of axonogenesis

description: Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.


endothelial cell migration

description: The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.


name: SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2


membrane lipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane.


ceramide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.


sphingolipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


humoral immune response

description: An immune response mediated through a body fluid.


antibacterial humoral response

description: An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.


name: antimicrobial humoral immune response mediated by antimicrobial peptide

description: An immune response against microbes mediated by anti-microbial peptides in body fluid.


name: defense response to Gram-positive bacterium

description: Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.


name: defense response to Gram-negative bacterium

description: Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.


defense response to bacterium

description: Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.


antimicrobial humoral response

description: An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.


name: AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B


name: AMYLOID BETA PRECURSOR PROTEIN BINDING FAMILY B MEMBER 2


name: AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 3


name: AMYLOID BETA PRECURSOR PROTEIN BINDING FAMILY B MEMBER 1


name: Alzheimer disease-amyloid secretase pathway


amyloid-beta binding

description: Binding to an amyloid-beta peptide/protein.


name: BROMODOMAIN AND WD REPEAT-CONTAINING PROTEIN 1


name: BROMODOMAIN AND WD REPEAT-CONTAINING PROTEIN 3


name: CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN


name: CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-7


name: CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2


name: CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 5


name: ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8


name: ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2


name: ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1


prenyltransferase activity

description: Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor).


isoprenoid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.


ubiquinone biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.


name: U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM4


U1 snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U1, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U1 snRNP, most of which remain associated with the U1 snRNA both while the U1 snRNP is free or assembled into a series of spliceosomal complexes.


U2-type spliceosomal complex

description: Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends.


U4 snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes.


U5 snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes.


SMN-Sm protein complex

description: A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm.


spliceosomal snRNP complex

description: A small ribonucleoprotein complex involved in formation of the spliceosome.


small nuclear ribonucleoprotein complex

description: A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs.


U2 snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes.


spliceosomal tri-snRNP complex

description: A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP.


precatalytic spliceosome

description: A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.


Sm-like protein family complex

description: A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles.


pICln-Sm protein complex

description: A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.


U6 snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U6, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6 snRNP, most of which remain associated with the U6 snRNA both while the U6 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes.


P-body

description: A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.


cytoplasmic ribonucleoprotein granule

description: A ribonucleoprotein granule located in the cytoplasm.


ribonucleoprotein granule

description: A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.


snRNA binding

description: Binding to a small nuclear RNA (snRNA).


protein-RNA complex assembly

description: The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex.


spliceosomal snRNP assembly

description: The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.


P-body assembly

description: The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 24


name: NKG2-F TYPE II INTEGRAL MEMBRANE PROTEIN


name: NKG2-E TYPE II INTEGRAL MEMBRANE PROTEIN


name: NKG2-A_NKG2-B TYPE II INTEGRAL MEMBRANE PROTEIN


name: NKG2-C TYPE II INTEGRAL MEMBRANE PROTEIN


name: regulation of natural killer cell mediated immunity

description: Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity.


name: positive regulation of natural killer cell mediated cytotoxicity

description: Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.


name: regulation of leukocyte mediated cytotoxicity

description: Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.


name: regulation of lymphocyte mediated immunity

description: Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.


name: positive regulation of response to external stimulus

description: Any process that activates, maintains or increases the rate of a response to an external stimulus.


name: positive regulation of innate immune response

description: Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.


name: regulation of natural killer cell mediated cytotoxicity

description: Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.


regulation of innate immune response

description: Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.


name: regulation of response to biotic stimulus

description: Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.


regulation of immune effector process

description: Any process that modulates the frequency, rate, or extent of an immune effector process.


name: innate immune response-activating signaling pathway

description: The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an innate immune response.


activation of innate immune response

description: Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.


regulation of cell killing

description: Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism.


name: regulation of leukocyte mediated immunity

description: Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.


positive regulation of defense response

description: Any process that activates or increases the frequency, rate or extent of a defense response.


name: positive regulation of response to biotic stimulus

description: Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.


name: MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A  MS4A -RELATED


name: MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 3


name: MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 13


name: MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 6E


name: MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 12


name: MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 18


name: MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 4A


name: HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT BETA


name: MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 7


name: MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 6A


name: MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 8


name: MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 5


name: MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 15


name: MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 14


name: MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 10


name: EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 11


centriole assembly

description: A cellular process that results in the assembly of one or more centrioles.


nucleotide-excision repair

description: A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).


centriole replication

description: The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.


name: regulation of release of sequestered calcium ion into cytosol

description: Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.


name: positive regulation of cation channel activity

description: Any process that activates or increases the frequency, rate or extent of cation channel activity.


regulation of calcium ion transport

description: Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


growth factor activity

description: The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.


name: fibroblast growth factor receptor binding

description: Binding to a fibroblast growth factor receptor (FGFR).


response to fibroblast growth factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus.


name: fibroblast growth factor receptor signaling pathway

description: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.


name: cellular response to fibroblast growth factor stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.


positive chemotaxis

description: The directed movement of a motile cell or organism towards a higher concentration of a chemical.


name: TRANSCRIPTION INTERMEDIARY FACTOR 1-ALPHA


name: BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2A


name: BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B


heterochromatin

description: A compact and highly condensed form of chromatin that is refractory to transcription.


name: COILED-COIL DOMAIN-CONTAINING PROTEIN 181


name: COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED


name: COMPLEMENT C1R SUBCOMPONENT-LIKE PROTEIN


trans-Golgi network transport vesicle

description: A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.


myosin binding

description: Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.


regulated exocytosis

description: A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.


calcium-ion regulated exocytosis

description: The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.


synaptic vesicle exocytosis

description: Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.


protein kinase A signaling

description: An intracellular signaling cassette that starts with the activation of protein kinase A (PKA), and ends with the regulation of a downstream cellular process, e.g. transcription. The PKA catalytic subunit (PKA-C) is normally present in a complex with its regulatory subunit, PKA-R. The inhibitory action of PKA-R is released upon cAMP binding, which results in the activation of PKA-C.


name: CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6


name: CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6-LIKE


3'-5'-RNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.


3'-5' exonuclease activity

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.


RNA nuclease activity

description: Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.


mRNA 3'-UTR binding

description: Binding to a 3' untranslated region of an mRNA molecule.


RNA destabilization

description: Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes.


regulation of RNA stability

description: Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs.


name: positive regulation of mRNA catabolic process

description: Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.


mRNA destabilization

description: Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.


name: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

description: A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.


regulation of mRNA catabolic process

description: Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.


regulation of mRNA stability

description: Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.


mRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.


RNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.


name: nuclear-transcribed mRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.


mRNA stabilization

description: Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules.


RNA stabilization

description: Prevention of degradation of RNA molecules.


name: negative regulation of cellular catabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.


name: negative regulation of catabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.


name: negative regulation of RNA catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process.


chemokine receptor binding

description: Binding to a chemokine receptor.


name: SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN


name: A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED


name: CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 1


name: COILED-COIL DOMAIN-CONTAINING PROTEIN 62


name: RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT


name: CHROMOSOME ALIGNMENT-MAINTAINING PHOSPHOPROTEIN 1


mitotic cell cycle checkpoint signaling

description: A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.


DNA geometric change

description: The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases.


recombinational repair

description: A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.


name: regulation of mitotic cell cycle phase transition

description: Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition.


name: double-strand break repair via homologous recombination

description: The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.


DNA recombination

description: Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.


name: negative regulation of G2/M transition of mitotic cell cycle

description: Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.


mitotic G2/M transition checkpoint

description: A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle.


name: mitotic G2 DNA damage checkpoint signaling

description: A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.


double-strand break repair

description: The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.


name: negative regulation of mitotic cell cycle phase transition

description: Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition.


DNA duplex unwinding

description: The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.


name: negative regulation of mitotic cell cycle

description: Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.


DNA conformation change

description: A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule.


name: mitotic DNA integrity checkpoint signaling

description: A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.


name: regulation of G2/M transition of mitotic cell cycle

description: Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.


mitotic DNA damage checkpoint signaling

description: A signal transduction process involved in mitotic DNA damage checkpoint.


name: RBPJ-INTERACTING AND TUBULIN-ASSOCIATED PROTEIN 1


name: negative regulation of Notch signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.


peptidase activator activity

description: Binds to and increases the activity of a peptidase.


name: EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED


name: EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6


skeletal muscle contraction

description: A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.


name: ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15


cytoplasmic translation

description: The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.


name: SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 3C


name: LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 1


name: LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 3


name: LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 4


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 29


name: LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 2


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 3B


name: TLR4 INTERACTOR WITH LEUCINE RICH REPEATS


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 24


name: LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 4


name: TRANSFORMING GROWTH FACTOR BETA ACTIVATOR LRRC32


name: LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 3


name: LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 1


name: LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1


name: LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 3


name: LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 2


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 17


name: INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT


name: SH3 DOMAIN-CONTAINING KINASE-BINDING PROTEIN 1


name: SORBIN AND SH3 DOMAIN-CONTAINING PROTEIN 1


name: SORBIN AND SH3 DOMAIN-CONTAINING PROTEIN 2


synaptic vesicle endocytosis

description: A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.


protein depolymerization

description: The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein.


synaptic vesicle recycling

description: The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane.


name: positive regulation of proteasomal protein catabolic process

description: Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.


regulation of protein catabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.


name: regulation of proteolysis involved in protein catabolic process

description: Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process.


positive regulation of JNK cascade

description: Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.


name: positive regulation of proteasomal ubiquitin-dependent protein catabolic process

description: Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


name: regulation of ubiquitin-dependent protein catabolic process

description: Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


name: positive regulation of proteolysis involved in protein catabolic process

description: Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process.


name: positive regulation of ubiquitin-dependent protein catabolic process

description: Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


name: regulation of proteasomal protein catabolic process

description: Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.


name: positive regulation of protein catabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.


name: regulation of proteasomal ubiquitin-dependent protein catabolic process

description: Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


name: MEMBRANE-ASSOCIATED GUANYLATE KINASE  MAGUK


basolateral plasma membrane

description: The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.


name: NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3


name: NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1


name: NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2


name: NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4


cytokine production

description: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


calcineurin-mediated signaling

description: Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression.


name: ATP-DEPENDENT RNA HELICASE DDX20-RELATED


name: ATP-DEPENDENT RNA HELICASE DDX17-RELATED


name: ATP-DEPENDENT RNA HELICASE DDX23-RELATED


name: ATP-DEPENDENT RNA HELICASE DDX41-RELATED


name: ATP-DEPENDENT RNA HELICASE DDX59-RELATED


name: ATP-DEPENDENT RNA HELICASE DDX43-RELATED


name: ATP-DEPENDENT RNA HELICASE DDX53-RELATED


cytoplasmic stress granule

description: A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.


SMN complex

description: A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus.


P granule

description: A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes.


poly(A)+ mRNA export from nucleus

description: The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.


name: alternative mRNA splicing, via spliceosome

description: The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.


name: TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG


tRNA methyltransferase activity

description: Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.


tRNA modification

description: The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.


tRNA methylation

description: The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.


3'-5'-DNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule.


name: HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE


receptor internalization

description: A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.


name: EMILIN  ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN   ELASTIN MICROFIBRIL INTERFACER


name: COMPLEMENT C1Q AND TUMOR NECROSIS FACTOR-RELATED PROTEIN 9B


name: COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 5


name: COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 2


name: COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 7


name: COMPLEMENT C1Q AND TUMOR NECROSIS FACTOR-RELATED PROTEIN 9A


name: BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE


name: BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1


name: BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2


endosome to lysosome transport

description: The directed movement of substances from endosomes to lysosomes.


lysosomal transport

description: The directed movement of substances into, out of or within a lysosome.


name: CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A


name: CHLORIDE INTRACELLULAR CHANNEL PROTEIN 2


name: CHLORIDE INTRACELLULAR CHANNEL PROTEIN 3


name: CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1


name: CHLORIDE INTRACELLULAR CHANNEL PROTEIN 4


chloride channel activity

description: Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel.


name: chloride transmembrane transporter activity

description: Enables the transfer of chloride ions from one side of a membrane to the other.


name: inorganic anion transmembrane transporter activity

description: Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.


chloride transport

description: The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


potassium channel activity

description: Enables the energy-independent facilitated diffusion of a potassium ion through a transmembrane aqueous pore or channel.


name: potassium ion transmembrane transporter activity

description: Enables the transfer of potassium ions (K+) from one side of a membrane to the other.


name: voltage-gated potassium channel activity

description: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


potassium ion transmembrane transport

description: A process in which a potassium ion is transported from one side of a membrane to the other.


potassium ion transport

description: The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 2


name: TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 7


name: TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3


name: POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN


name: TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 5


name: TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4


name: TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1


name: TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 6


name: PROTEIN PHOSPHATASE INHIBITOR AND DOPAMINE- AND CAMP-REGULATED NEURONAL PHOSPHOPROTEIN


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1C


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1A


preribosome

description: Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis.


preribosome, large subunit precursor

description: A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.


ribosomal large subunit assembly

description: The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.


name: (E2-INDEPENDENT) E3 UBIQUITIN-CONJUGATING ENZYME FATS


regulation of organelle assembly

description: Any process that modulates the frequency, rate or extent of organelle assembly.


regulation of centriole replication

description: Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole.


name: 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED


name: MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 3


name: MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 4


name: MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 2


name: MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 1


spindle pole

description: Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.


potassium channel regulator activity

description: Binds to and modulates the activity of a potassium channel.


peptidyl-serine phosphorylation

description: The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.


peptidyl-serine modification

description: The modification of peptidyl-serine.


regulation of growth

description: Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.


hippo signaling

description: An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.


regulation of heart contraction

description: Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.


SCF ubiquitin ligase complex

description: A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).


name: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


name: ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3


name: FAMILY WITH SEQUENCE SIMILARITY 241 MEMBER A


glucuronosyltransferase activity

description: Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.


UDP-galactosyltransferase activity

description: Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule.


galactosyltransferase activity

description: Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


glycosphingolipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.


glycolipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).


name: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2


name: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1


name: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3


name: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10


name: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 11


name: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6


name: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14


name: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15


name: tumor necrosis factor receptor superfamily binding

description: Binding to a member of the tumor necrosis factor receptor superfamily.


name: extrinsic apoptotic signaling pathway via death domain receptors

description: The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.


extrinsic apoptotic signaling pathway

description: The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.


name: SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 14


name: SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 11


name: SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 5


name: SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 7


name: SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 1


name: SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 4


name: SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 2


name: SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 9


name: SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 3


name: sugar transmembrane transporter activity

description: Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides.


name: carbohydrate transmembrane transporter activity

description: Enables the transfer of carbohydrate from one side of a membrane to the other.


vitamin transport

description: The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.


glucose transmembrane transport

description: The process in which glucose is transported across a membrane.


carbohydrate transmembrane transport

description: The process in which a carbohydrate is transported across a membrane.


carbohydrate transport

description: The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.


name: NUCLEOLAR PROTEIN 5  NUCLEOLAR PROTEIN NOP5  NOP58


description: A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family and associated proteins. Many are involved in a step of processing of rRNA molecules: cleavage, 2'-O-methylation, or pseudouridylation, but other RNA types can be targets as well. The majority fall into one of two classes, box C/D type or box H/ACA type, which are conserved across eukaryotes and archaea. Other members include the telomerase RNA and the ribonuclease MRP RNA.


small-subunit processome

description: A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.


snoRNA binding

description: Binding to a small nucleolar RNA.


name: ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR


name: Beta3 adrenergic receptor signaling pathway


name: regulation of adenylate cyclase activity

description: Any process that modulates the frequency, rate or extent of adenylate cyclase activity.


negative regulation of lyase activity

description: Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


regulation of lyase activity

description: Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.


negative regulation of cyclase activity

description: Any process that stops or reduces the activity of a cyclase.


regulation of cyclase activity

description: Any process that modulates the frequency, rate or extent of cyclase activity.


name: negative regulation of adenylate cyclase activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.


name: regulation of synaptic transmission, glutamatergic

description: Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.


negative regulation of blood pressure

description: Any process in which the force of blood traveling through the circulatory system is decreased.


name: DIFFUSE PANBRONCHIOLITIS CRITICAL REGION GENE 1


name: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN G


name: MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED GENE PROTEIN


name: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B ALPHA CHAIN


name: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN F


name: T-CELL SURFACE GLYCOPROTEIN CD1E, MEMBRANE-ASSOCIATED


name: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN


name: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN H-RELATED


name: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A ALPHA CHAIN


name: MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE A-RELATED


name: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN E


antigen binding

description: Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. Antigen binding by an MHC protein complex allows the antigen to be displayed to a T cell or NK cell.


antigen processing and presentation

description: The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.


name: positive regulation of adaptive immune response

description: Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.


name: SODIUM-COUPLED NEUTRAL AMINO ACID SYMPORTER 1


name: SODIUM-COUPLED NEUTRAL AMINO ACID SYMPORTER 2


name: SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 4


name: SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 3


name: SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 10-RELATED


name: SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 7


name: SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 6-RELATED


name: SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 8-RELATED


name: SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 5


name: SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED