EMC complex

description: A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.


name: POST-GPI ATTACHMENT TO PROTEINS FACTOR 6


name: FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED


spindle midzone

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The area in the center of the spindle where the spindle microtubules from opposite poles overlap.


synaptic vesicle transport

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The directed movement of synaptic vesicles.


microtubule depolymerization

description: The removal of tubulin heterodimers from one or both ends of a microtubule.


name: SOLUTE CARRIER FAMILY 34  SODIUM PHOSPHATE , MEMBER 2-RELATED


name: SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2C


name: SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2A


name: SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B


name: BMERB DOMAIN-CONTAINING PROTEIN 1-RELATED


name: MICOS COMPLEX SUBUNIT MIC26 / MIC27 FAMILY MEMBER


carbohydrate kinase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule.


name: PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED


sperm principal piece

description: The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.


name: LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 4-LIKE ISOFORM X1


name: LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 3


name: LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 4


name: DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 2B


name: DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 2C


name: DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 2


name: FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1


name: PPP2R1A-PPP2R2A-INTERACTING PHOSPHATASE REGULATOR 1


name: TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54


name: XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER


name: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2


name: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11


name: NH 3 /GLUTAMINE-DEPENDENT NAD +  SYNTHETASE


name: G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE


name: RIBOSOMAL PROTEIN S6 KINASE-RELATED PROTEIN


name: SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2-RELATED


name: SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1


name: SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3


name: CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED


name: EH DOMAIN-BINDING PROTEIN 1-LIKE PROTEIN 1


name: EXOSTOSIN  HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED


name: ELECTRONEUTRAL SODIUM BICARBONATE EXCHANGER 1


name: SODIUM-DRIVEN CHLORIDE BICARBONATE EXCHANGER


name: ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 1


name: ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4


name: ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2


name: CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 52


name: CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 251


name: ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 6


name: ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 5


name: ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 4


name: ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 1


name: ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 3


lipid droplet

description: An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.


lipid storage

description: The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.


name: CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED


intraciliary transport particle A

description: The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa.


intraciliary transport particle

description: A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.


name: (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME


name: BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6


name: cysteine-type endopeptidase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase.


ubiquitin conjugating enzyme activity

description: Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.


name: SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN


name: SPECTRIN ALPHA CHAIN, NON-ERYTHROCYTIC 1


cortical actin cytoskeleton

description: The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.


name: VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE


name: TOG ARRAY REGULATOR OF AXONEMAL MICROTUBULES PROTEIN 1


name: TOG ARRAY REGULATOR OF AXONEMAL MICROTUBULES PROTEIN 2


name: V-TYPE IMMUNOGLOBULIN DOMAIN-CONTAINING SUPPRESSOR OF T-CELL ACTIVATION


protein-disulfide reductase activity

description: Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.


disulfide oxidoreductase activity

description: Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.


name: oxidoreductase activity, acting on a sulfur group of donors

description: Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


name: G-PROTEIN COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 2


name: G PROTEIN-COUPLED RECEPTOR ASSOCIATED SORTING PROTEIN 3


name: G-PROTEIN COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 1


name: BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED


name: CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 23


name: CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 22


name: CLASS A BASIC HELIX-LOOP-HELIX PROTEIN 15


name: DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED


name: BASIC IMMUNOGLOBULIN-LIKE VARIABLE MOTIF-CONTAINING PROTEIN


name: FATTY ACID HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2-RELATED


sterol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


name: AMILORIDE-SENSITIVE AMINE OXIDASE [COPPER-CONTAINING]


membrane invagination

description: The infolding of a membrane.


phagocytosis, engulfment

description: The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.


apoptotic cell clearance

description: The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.


anaphase-promoting complex

description: A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.


regulation of mitotic nuclear division

description: Any process that modulates the frequency, rate or extent of mitosis.


regulation of chromosome segregation

description: Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.


regulation of chromosome separation

description: Any process that modulates the frequency, rate or extent of chromosome separation.


regulation of chromosome organization

description: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.


name: regulation of mitotic sister chromatid separation

description: Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis.


name: regulation of metaphase/anaphase transition of cell cycle

description: Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of cell cycle.


name: positive regulation of mitotic nuclear division

description: Any process that activates or increases the frequency, rate or extent of mitosis.


name: regulation of mitotic metaphase/anaphase transition

description: Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.


name: regulation of sister chromatid segregation

description: Any process that modulates the frequency, rate or extent of sister chromatid segregation.


name: SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1


name: CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 2


name: CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 1


name: CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2


inner dynein arm assembly

description: The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.


name: ubiquitin-like ligase-substrate adaptor activity

description: The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins.


name: SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED


name: SERINE_ARGININE REPETITIVE MATRIX PROTEIN 2


name: SERINE_ARGININE REPETITIVE MATRIX PROTEIN 4


name: SERINE_ARGININE REPETITIVE MATRIX PROTEIN 3


name: PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1  PGC-1 -RELATED


name: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA


name: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-BETA


name: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR-RELATED PROTEIN 1


nuclear receptor coactivator activity

description: A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.


name: ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 10


name: NOTCH-REGULATED ANKYRIN REPEAT-CONTAINING PROTEIN


name: ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 6


name: BROMODOMAIN AND PHD FINGER-CONTAINING PROTEIN 3


name: COILED-COIL DOMAIN-CONTAINING PROTEIN 82


name: GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN


name: DIACYLGLYCEROL O-ACYLTRANSFERASE 2-LIKE PROTEIN 6


triglyceride biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.


name: UDP-SUGAR TRANSPORTER PROTEIN SLC35A5-RELATED


name: UDP-SUGAR TRANSPORTER PROTEIN SLC35A4-RELATED


name: PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED


name: GLUTAMINE AMIDOTRANSFERASE-LIKE CLASS 1 DOMAIN-CONTAINING PROTEIN 1


name: MITOCHONDRIAL OUTER MEMBRANE PROTEIN SLC25A46


mitochondrial fission

description: The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.


name: FATTY ACID DESATURASE 2-LIKE PROTEIN FADS2B-RELATED


name: SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT


name: SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT


name: SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT


name: FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED


name: DNA DAMAGE-REGULATED AUTOPHAGY MODULATOR PROTEIN 2


name: DNA DAMAGE-REGULATED AUTOPHAGY MODULATOR PROTEIN 1


retina homeostasis

description: A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.


name: ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 2


name: TRANSMEMBRANE ASCORBATE-DEPENDENT REDUCTASE CYB561


name: PLASMA MEMBRANE ASCORBATE-DEPENDENT REDUCTASE CYBRD1


name: LYSOSOMAL MEMBRANE ASCORBATE-DEPENDENT FERRIREDUCTASE CYB561A3


heat shock protein binding

description: Binding to a heat shock protein, a protein synthesized or activated in response to heat shock.


Hsp90 protein binding

description: Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 5


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 8


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 2


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 6


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 1


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 4


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 7


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 39


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 26


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 6


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 25


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 20


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 2


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 17


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 49


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 34


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 1


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 37


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 32


name: POZ-, AT HOOK-, AND ZINC FINGER-CONTAINING PROTEIN 1


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 14


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 12


name: ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 45


name: MEMBRANE TRANSPORT PROTEIN XK FAMILY MEMBER


name: ENDOPLASMIC RETICULUM MEMBRANE ADAPTER PROTEIN XK


name: TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 1


endoplasmic reticulum tubular network

description: A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section.


name: ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI


name: ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 6


name: ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 8


name: ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 4


name: GALACTOSIDE-BINDING SOLUBLE LECTIN 13-RELATED


name: negative regulation of extrinsic apoptotic signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.


regulation of endocytosis

description: Any process that modulates the frequency, rate or extent of endocytosis.


macrophage chemotaxis

description: The movement of a macrophage in response to an external stimulus.


name: negative regulation of apoptotic signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.


negative regulation of endocytosis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.


name: ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10


name: G PATCH DOMAIN-CONTAINING PROTEIN 2-LIKE


name: SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED


U2-type prespliceosome

description: A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.


Pyrimidine Metabolism

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: HEAT SHOCK PROTEIN HSP 90-BETA-3-RELATED


name: HEAT SHOCK PROTEIN 75 KDA, MITOCHONDRIAL-RELATED


name: HEAT SHOCK PROTEIN HSP 90-BETA 2-RELATED


response to heat

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.


cellular response to heat

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.


site of DNA damage

description: A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.


site of double-strand break

description: A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.


name: CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL


hormone biosynthetic process

description: The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.


name: GLUCOSE-INDUCED DEGRADATION PROTEIN 8 HOMOLOG


name: INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN


name: INTERLEUKIN-18 RECEPTOR ACCESSORY PROTEIN


name: X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 2


name: INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 1


regulation of stress fiber assembly

description: Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.


name: regulation of actin filament bundle assembly

description: Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles.


name: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT


name: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1


name: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2


name: TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8-LIKE PROTEIN 3


name: TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8-LIKE PROTEIN 1


name: TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8


name: TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8-LIKE PROTEIN 2


name: GROWTH HORMONE-RELEASING HORMONE RECEPTOR


name: VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2


name: CORTICOTROPIN-RELEASING FACTOR RECEPTOR 2


name: CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR


name: VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1


name: PARATHYROID HORMONE_PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR


name: CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1


name: PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE TYPE I RECEPTOR


name: Cortocotropin releasing factor receptor signaling pathway


name: DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 6-RELATED


name: DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 4


name: MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10


name: HIPPOCAMPUS ABUNDANT TRANSCRIPT-LIKE PROTEIN 1


name: MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 9


name: HIPPOCAMPUS ABUNDANT TRANSCRIPT 1 PROTEIN


arginine metabolic process

description: The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.


peptide N-acetyltransferase activity

description: Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide.


histone acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.


description: Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide.


name: SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL


name: INTERMEDIATE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 4


name: SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 2


name: SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 1


name: SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 3


name: calcium-activated potassium channel activity

description: Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient.


name: NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6


canonical inflammasome complex

description: A cytosolic protein complex that is capable of activating caspase-1.


name: cysteine-type endopeptidase activity involved in apoptotic process

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process.


erythrocyte differentiation

description: The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.


name: positive regulation of inflammatory response

description: Any process that activates or increases the frequency, rate or extent of the inflammatory response.


name: UBIQUITIN-CONJUGATING ENZYME E2 N-LIKE-RELATED


name: UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 1


name: UBIQUITIN-CONJUGATING ENZYME E2Q-LIKE PROTEIN 1


name: UBIQUITIN_ISG15-CONJUGATING ENZYME E2 L6


name: UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2


protein K11-linked ubiquitination

description: A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.


protein K48-linked ubiquitination

description: A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.


name: anaphase-promoting complex-dependent catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.


name: SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL


name: SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL


tricarboxylic acid cycle

description: A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.


name: ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 1


name: ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 7


name: ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 3


name: ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 6


name: NUCLEOSIDE DIPHOSPHATE PHOSPHATASE ENTPD5


name: ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 4


name: ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2


name: ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 8


name: nucleoside diphosphate phosphatase activity

description: Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate.


pyrimidine nucleotide metabolic process

description: The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


name: pyrimidine-containing compound metabolic process

description: The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof.


name: SPERM ACROSOME MEMBRANE-ASSOCIATED PROTEIN 1


name: 60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL


name: positive regulation of type I interferon production

description: Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


name: NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2


name: APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1


name: NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1


name: E3 UBIQUITIN-PROTEIN LIGASE ITCHY HOMOLOG


neuromuscular junction development

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.


name: GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN


name: ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA2


name: ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1


name: ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA3


name: LIPOPOLYSACCHARIDE-RESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN


name: INTERFERON-INDUCED GTP-BINDING PROTEIN MX1


name: INTERFERON-INDUCED GTP-BINDING PROTEIN MX2


name: DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL


name: NEURONAL PAS DOMAIN-CONTAINING PROTEIN 1


name: NEURONAL PAS DOMAIN-CONTAINING PROTEIN 3


name: NEURONAL PAS DOMAIN-CONTAINING PROTEIN 4


name: ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1


name: RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF


name: RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2


name: RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1


name: RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP3


actomyosin contractile ring assembly

description: The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.


mitotic cytokinetic process

description: Any cytokinetic process that is involved in mitotic cell cycle.


cytokinetic process

description: A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).


name: BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST


name: BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR SCLERAXIS


name: HEART- AND NEURAL CREST DERIVATIVES-EXPRESSED PROTEIN 2


name: HEART- AND NEURAL CREST DERIVATIVES-EXPRESSED PROTEIN 1


name: CLASS A BASIC HELIX-LOOP-HELIX PROTEIN 9


name: PANCREAS TRANSCRIPTION FACTOR 1 SUBUNIT ALPHA


skeletal muscle organ development

description: The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue.


muscle organ development

description: The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.


skeletal muscle tissue development

description: The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.


name: SMG-7  SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7


name: NONSENSE-MEDIATED MRNA DECAY FACTOR SMG7


name: NONSENSE-MEDIATED MRNA DECAY FACTOR SMG5


telomeric DNA binding

description: Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.


name: SIMILAR TO CHROMOSOME 1 OPEN READING FRAME 50


name: SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN  SCAMP


name: SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 1


name: SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 3


name: SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 2


name: SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 5


name: SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 4


recycling endosome membrane

description: The lipid bilayer surrounding a recycling endosome.


negative regulation of autophagy

description: Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.


negative regulation of macroautophagy

description: Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.


regulation of autophagosome maturation

description: Any process that modulates the frequency, rate or extent of autophagosome maturation.


chromosome condensation

description: The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.


mitotic chromosome condensation

description: The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.


name: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6


death receptor activity

description: Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death.


neuron apoptotic process

description: Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.


name: PROTEIN KINASE DOMAIN-CONTAINING PROTEIN


name: EXTRACELLULAR TYROSINE-PROTEIN KINASE PKDCC


name: non-membrane spanning protein tyrosine kinase activity

description: Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.


name: ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1


name: SERINE/THREONINE PROTEIN PHOSPHATASE 2A  PP2A  REGULATORY SUBUNIT B


name: SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM


name: SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM


name: SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM


name: SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM


name: SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM


name: GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR


lipopolysaccharide binding

description: Binding to a lipopolysaccharide.


name: CALCIUM-BINDING AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1


name: CALCIUM-BINDING AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2


mitochondrial gene expression

description: The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.


mitochondrial translation

description: The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.


name: IQ CALMODULIN-BINDING MOTIF CONTAINING PROTEIN 1


name: IQ CALMODULIN-BINDING MOTIF-CONTAINING PROTEIN 1


name: BILE ACID-COA:AMINO ACID N-ACYLTRANSFERASE


name: PEROXISOMAL SUCCINYL-COENZYME A THIOESTERASE


fatty acyl-CoA hydrolase activity

description: Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.


thiolester hydrolase activity

description: Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.


name: EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1


translational termination

description: The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).


name: CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED


name: GLUTAMINE AND SERINE-RICH PROTEIN 1-RELATED


name: BCL-2_ADENOVIRUS E1B 19 KDA-INTERACTING PROTEIN 2-LIKE PROTEIN


name: BCL2_ADENOVIRUS E1B 19 KDA PROTEIN-INTERACTING PROTEIN 2


exopolyphosphatase activity

description: Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate.


name: ANKYRIN REPEAT AND SAM DOMAIN-CONTAINING PROTEIN 3


name: INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2


name: INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3


name: INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1


name: Histamine H1 receptor mediated signaling pathway


name: SMALL RIBOSOMAL SUBUNIT PROTEIN US2-RELATED


cytosolic small ribosomal subunit

description: The small subunit of a ribosome located in the cytosol.


small ribosomal subunit

description: The smaller of the two subunits of a ribosome.


sialyltransferase activity

description: Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.


name: SERINE_ARGININE-RICH SPLICING FACTOR 4-RELATED


name: C-TYPE LECTIN DOMAIN FAMILY 18 MEMBER A-RELATED


name: GOLGI-ASSOCIATED PLANT PATHOGENESIS-RELATED PROTEIN 1


name: CYSTEINE-RICH SECRETORY PROTEIN LCCL DOMAIN-CONTAINING 2


name: CYSTEINE-RICH SECRETORY PROTEIN LCCL DOMAIN-CONTAINING 1


sperm-egg recognition

description: The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization.


binding of sperm to zona pellucida

description: The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.


cell-cell recognition

description: Cell recognition between cells. May involve the formation of specialized cell junctions.


name: PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED


name: RAS_RAP GTPASE-ACTIVATING PROTEIN SYNGAP


name: ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR


activin binding

description: Binding to activin, a dimer of inhibin-beta subunits.


name: chaperone-mediated protein complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.


name: RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1


name: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5


name: RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1


name: RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 3


name: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2


name: RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1B


name: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4


name: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR-LIKE 1


name: RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 2


name: RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1C


name: RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR


name: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 3


name: RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1A


name: RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS1


name: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6


name: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1


name: RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS2


name: CYSTEINE AND HISTIDINE-RICH DOMAIN  CHORD -CONTAINING PROTEIN


name: CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1


name: regulation of response to endoplasmic reticulum stress

description: Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress.


name: TATA-BINDING PROTEIN-ASSOCIATED FACTOR 2N


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7


name: PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 42


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 49


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46


name: LEUCINE-RICH REPEAT-CONTAINING PROTEIN 43


name: CARNITINE O-PALMITOYLTRANSFERASE 1, MUSCLE ISOFORM


name: CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL


name: CARNITINE O-PALMITOYLTRANSFERASE 1, BRAIN ISOFORM


name: CARNITINE O-PALMITOYLTRANSFERASE 1, LIVER ISOFORM


neuromuscular synaptic transmission

description: The process of synaptic transmission from a neuron to a muscle, across a synapse.


name: UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1


name: ADAM  A DISINTEGRIN AND METALLOPROTEASE DOMAIN


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 20


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 23


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 22


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 29


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 18


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 8


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 32


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 15


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 30


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 19


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 11


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 7


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 28


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 12


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 2


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 21


name: DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33


membrane protein proteolysis

description: The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.


membrane protein ectodomain proteolysis

description: The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).


name: NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 17


NADP metabolic process

description: The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.


name: MAP KINASE KINASE KINASE SSK2-RELATED-RELATED


name: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8


name: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19


name: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4


name: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14


name: DELETED IN AZOOSPERMIA PROTEIN 1-RELATED


name: AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN


name: RAS-ASSOCIATED AND PLECKSTRIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1


interstrand cross-link repair

description: Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.


name: mitotic intra-S DNA damage checkpoint signaling

description: A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.


name: VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN


name: VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN B_C


name: VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A


name: POLYCYSTIN FAMILY RECEPTOR FOR EGG JELLY


name: OSTEOPETROSIS ASSOCIATED TRANSMEMBRANE PROTEIN 1


name: OSTEOPETROSIS-ASSOCIATED TRANSMEMBRANE PROTEIN 1


name: FAS-ASSOCIATING DEATH DOMAIN-CONTAINING PROTEIN FADD


name: HIGH AFFINITY IMMUNOGLOBULIN GAMMA FC RECEPTOR I-RELATED


name: PLATELET ENDOTHELIAL CELL ADHESION MOLECULE


name: LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR II-B-RELATED


name: LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR III-A-RELATED


name: HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT ALPHA


name: LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR II-A


cell killing

description: Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.


positive regulation of phagocytosis

description: Any process that activates or increases the frequency, rate or extent of phagocytosis.


leukocyte mediated cytotoxicity

description: The directed killing of a target cell by a leukocyte.


positive regulation of endocytosis

description: Any process that activates or increases the frequency, rate or extent of endocytosis.


name: CHARGED MULTIVESICULAR BODY PROTEIN 4B-LIKE PROTEIN CHMP4BP1-RELATED


name: SODIUM-DEPENDENT PHOSPHATE TRANSPORTER 1


name: SODIUM-DEPENDENT PHOSPHATE TRANSPORTER 2


name: CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65


name: UDP-N-ACETYLHEXOSAMINE PYROPHOSPHORYLASE-LIKE PROTEIN 1


name: NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1


name: NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1


name: CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3


aminopeptidase activity

description: Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.


metalloaminopeptidase activity

description: Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


name: HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED


name: HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR


name: BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7


name: BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5


tRNA binding

description: Binding to a transfer RNA.


name: HOMEODOMAIN-INTERACTING PROTEIN KINASE 4


name: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4


name: HOMEODOMAIN-INTERACTING PROTEIN KINASE 3


name: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1B


name: HOMEODOMAIN-INTERACTING PROTEIN KINASE 2


name: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A


name: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3


name: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 2


name: HOMEODOMAIN-INTERACTING PROTEIN KINASE 1


peptidyl-threonine phosphorylation

description: The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.


name: MICROTUBULE-ASSOCIATED TYROSINE CARBOXYPEPTIDASE 1


name: THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL


name: INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA


name: INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON


name: INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA


name: tumor necrosis factor-mediated signaling pathway

description: The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


response to tumor necrosis factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.


name: cellular response to tumor necrosis factor

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.


TORC2 signaling

description: A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.


TOR signaling

description: The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.


positive regulation of cell division

description: Any process that activates or increases the frequency, rate or extent of cell division.


regulation of chromatin organization

description: Any process that modulates the frequency, rate or extent of chromatin organization.


name: NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1


name: oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein.


name: oxidoreductase activity, acting on metal ions

description: Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered.


name: ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING


name: ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 3


name: ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 2


name: GUANINE NUCLEOTIDE-BINDING PROTEIN BETA  G PROTEIN BETA


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(T) SUBUNIT BETA-2


name: GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(T) SUBUNIT BETA-3


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(T) SUBUNIT BETA-1


name: GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5


name: signaling receptor complex adaptor activity

description: The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex.


tissue remodeling

description: The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.


tetrapyrrole metabolic process

description: The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.


pigment metabolic process

description: The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.


name: porphyrin-containing compound metabolic process

description: The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.


heme metabolic process

description: The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.


name: CONSTITUTIVE COACTIVATOR OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA


name: CONSTITUTIVE COACTIVATOR OF PPAR-GAMMA-LIKE PROTEIN 1


name: CONSTITUTIVE COACTIVATOR OF PPAR-GAMMA-LIKE PROTEIN 2


name: REGULATOR OF G-PROTEIN SIGNALING 7-BINDING PROTEIN


name: REGULATOR OF G-PROTEIN SIGNALING 9-BINDING PROTEIN


name: PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE HHAT-LIKE PROTEIN


name: PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP], MITOCHONDRIAL


name: PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP]


carboxy-lyase activity

description: Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.


carbon-carbon lyase activity

description: Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


liver development

description: The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.


name: cellular response to steroid hormone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.


name: DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 2


name: DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 1


name: CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B


name: CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1


name: CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1


name: EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 13


name: HISTONE PARYLATION FACTOR 1-LIKE-RELATED


name: TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2


name: MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE


name: MITOCHONDRIAL MRNA PSEUDOURIDINE SYNTHASE RPUSD3


name: RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1


name: PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL


name: NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED


name: NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA-2


name: NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA, MUSCLE-SPECIFIC FORM


name: NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA-LIKE PROTEIN-RELATED


name: COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING


name: COMPLEMENT COMPONENT RECEPTOR 1-LIKE PROTEIN


name: SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1


name: TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED


name: TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1


name: SIMILAR TO HUMAN CHROMOSOME 6 OPEN READING FRAME 52


name: POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 3


name: POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 2


name: POU DOMAIN, CLASS 4, TRANSCRIPTION FACTOR 2


name: POU DOMAIN, CLASS 4, TRANSCRIPTION FACTOR 1


name: POU DOMAIN, CLASS 6, TRANSCRIPTION FACTOR 2


name: POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 3


name: POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 2


name: POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 1


name: POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 1


name: POU DOMAIN, CLASS 4, TRANSCRIPTION FACTOR 3


name: POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 4


name: POU DOMAIN, CLASS 5, TRANSCRIPTION FACTOR 1-RELATED


name: POU DOMAIN, CLASS 6, TRANSCRIPTION FACTOR 1


name: POU DOMAIN, CLASS 5, TRANSCRIPTION FACTOR 2


name: rRNA (adenine) methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine.


name: EXOSOME COMPLEX EXONUCLEASE  RIBOSOMAL RNA PROCESSING PROTEIN


exosome (RNase complex)

description: A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.


name: polyadenylation-dependent ncRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA.


name: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.


name: BASIC LEUCINE ZIPPER TRANSCRIPTIONAL FACTOR ATF-LIKE


name: BASIC LEUCINE ZIPPER TRANSCRIPTIONAL FACTOR ATF-LIKE 2


name: BASIC LEUCINE ZIPPER TRANSCRIPTIONAL FACTOR ATF-LIKE 3


name: CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3


name: P300 TRANSCRIPTIONAL COFACTOR JMY-RELATED


name: JUNCTION-MEDIATING AND -REGULATORY PROTEIN


name: WASP HOMOLOG-ASSOCIATED PROTEIN WITH ACTIN, MEMBRANES AND MICROTUBULES


name: LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G5B


name: CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS


name: CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 3


name: CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 1


name: CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2


name: MYOD FAMILY INHIBITOR DOMAIN-CONTAINING PROTEIN


name: MYOD FAMILY INHIBITOR DOMAIN-CONTAINING PROTEIN 2


name: RIBOSOMAL PROTEIN S6 MODIFICATION PROTEIN


name: TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER


name: PRELI DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL


actin monomer binding

description: Binding to monomeric actin, also known as G-actin.


name: PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE


name: PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN


name: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11A


regulation of tissue remodeling

description: Any process that modulates the frequency, rate, or extent of tissue remodeling.


immune system development

description: The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.


regulation of bone resorption

description: Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).


response to interleukin-1

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.


regulation of bone remodeling

description: Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.


name: SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT


name: SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A ALPHA ISOFORM


name: SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A BETA ISOFORM


name: SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1


name: E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED


name: FIBRONECTIN TYPE III AND SPRY DOMAIN-CONTAINING PROTEIN 2


name: FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 3B


name: FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 3A


name: E3 UBIQUITIN-PROTEIN LIGASE MID2-RELATED


name: FIBRONECTIN TYPE III AND SPRY DOMAIN-CONTAINING PROTEIN 1


acrosome reaction

description: The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.


name: regulation of mitotic spindle organization

description: Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.


name: CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 68


name: ADHESION G PROTEIN-COUPLED RECEPTOR E4P-RELATED


JNK cascade

description: A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.


name: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21


regulation of B cell proliferation

description: Any process that modulates the frequency, rate or extent of B cell proliferation.


name: COMPLEMENT FACTOR H-RELATED PROTEIN 1-RELATED


name: COMPLEMENT FACTOR H-RELATED PROTEIN 3-RELATED


complement binding

description: Binding to a component or product of the complement cascade.


name: VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL PROTEIN 1


name: VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL PROTEIN 2


name: VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL PROTEIN 3


name: ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS


name: TRANSCRIPTION FACTOR OVO-LIKE PROTEIN 3-RELATED


name: ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1


name: LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 1


name: EGF-CONTAINING FIBULIN-LIKE EXTRACELLULAR MATRIX PROTEIN 2


name: COLLAGEN AND CALCIUM-BINDING EGF DOMAIN-CONTAINING PROTEIN 1


name: LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 2


name: LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 3


name: LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 4


name: PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B


name: ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED


name: ZIPPER PUTATIVE TUMOR SUPPRESSOR 3-RELATED


name: ZIPPER PUTATIVE TUMOR SUPPRESSOR 1-RELATED


name: ZIPPER PUTATIVE TUMOR SUPPRESSOR 2-RELATED


name: low-density lipoprotein particle binding

description: Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.


name: V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN


name: V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2B


name: V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2A


name: PROSTAGLANDIN F2 RECEPTOR NEGATIVE REGULATOR


name: V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 4


name: V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN


name: B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR


sperm capacitation

description: A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.


name: MELANIN-CONCENTRATING HORMONE RECEPTOR 1


neuropeptide binding

description: Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).


neuropeptide receptor activity

description: Combining with a neuropeptide to initiate a change in cell activity.


response to estradiol

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.


regulation of insulin secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of insulin.


regulation of peptide secretion

description: Any process that modulates the frequency, rate, or extent of peptide secretion.


regulation of protein transport

description: Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


regulation of peptide hormone secretion

description: Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.


regulation of protein secretion

description: Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.


name: regulation of establishment of protein localization

description: Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.


regulation of peptide transport

description: Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


Hsp70 protein binding

description: Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.


name: chaperone cofactor-dependent protein refolding

description: The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.


'de novo' protein folding

description: The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure.


name: PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 3


name: PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 1


name: PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 2


name: PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 4


name: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ALPHA


name: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE MU


name: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE GAMMA


name: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE H


name: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE DELTA


name: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ZETA


name: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE U


name: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE T


name: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE F


name: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 7


name: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE S


name: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ETA


name: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 9


name: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON


name: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE KAPPA


name: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C


name: T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN


name: DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B


name: E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED


name: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN


name: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 3


name: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 2


name: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1


translation initiation factor binding

description: Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.


name: HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN-RELATED


name: IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB


name: PROTON-TRANSPORTING V-TYPE ATPASE COMPLEX ASSEMBLY REGULATOR TMEM9


name: SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2


name: negative regulation of protein catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process.


name: STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 10


name: STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 12


name: STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 10


name: SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN


hexokinase activity

description: Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.


carbohydrate phosphorylation

description: The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y.


name: GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2


name: GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-RELATED


name: COILED-COIL DOMAIN-CONTAINING PROTEIN 115


telomere organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins.


telomere maintenance

description: Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.


name: CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE


name: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 3


name: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 14


name: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 4


name: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 21


name: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 20


name: pattern recognition receptor signaling pathway

description: The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.


toll-like receptor 4 signaling pathway

description: The series of molecular signals initiated by a ligand binding to toll-like receptor 4.


name: positive regulation of leukocyte chemotaxis

description: Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.


name: TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 1


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 6


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 4


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 2


name: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 3


response to osmotic stress

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


name: RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER


name: MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG


name: ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 2


name: ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 3


name: ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 1


name: negative regulation of intrinsic apoptotic signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.


preribosome, small subunit precursor

description: A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.


name: positive regulation of protein secretion

description: Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.


name: positive regulation of insulin secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.


name: positive regulation of protein transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: positive regulation of establishment of protein localization

description: Any process that activates or increases the frequency, rate or extent of establishment of protein localization.


positive regulation of secretion

description: Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.


name: positive regulation of hormone secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.


name: positive regulation of protein localization

description: Any process that activates or increases the frequency, rate or extent of a protein localization.


name: positive regulation of secretion by cell

description: Any process that activates or increases the frequency, rate or extent of secretion by cell.


name: ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN


name: RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED


name: INTERFERON-STIMULATED 20 KDA EXONUCLEASE-LIKE 2


name: INTERFERON-STIMULATED GENE 20 KDA PROTEIN


name: HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L


name: HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L-LIKE


sensory organ morphogenesis

description: Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


ear development

description: The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.


inner ear development

description: The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.


inner ear morphogenesis

description: The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.


name: F-BOX AND LEUCINE-RICH REPEAT PROTEIN 13


name: DISTAL MEMBRANE-ARM ASSEMBLY COMPLEX PROTEIN 2


name: mitochondrial respiratory chain complex I assembly

description: The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.


pattern recognition receptor activity

description: Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response.


toll-like receptor signaling pathway

description: The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.


name: GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2


name: GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1


name: GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5


name: GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3


name: GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4


glutamate receptor activity

description: Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: chemical synaptic transmission, postsynaptic

description: The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol.


glutamate receptor signaling pathway

description: The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: MPS ONE BINDER KINASE ACTIVATOR-LIKE  MOB


name: PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED


filopodium

description: Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.


name: MAINTENANCE OF KILLER 16  MAK16  PROTEIN-RELATED


THO complex

description: The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.


transcription export complex

description: The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.


maturation of LSU-rRNA

description: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule.


name: GOLGI-ASSOCIATED OLFACTORY SIGNALING REGULATOR


name: PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED


name: GUANINE NUCLEOTIDE EXCHANGE FACTOR MCF2L2-RELATED


name: ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 5


name: ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 5-LIKE PROTEIN


name: MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED


name: MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 1


name: MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 2


name: SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED


name: COILED-COIL DOMAIN-CONTAINING PROTEIN 191


name: HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 2


name: HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 1


name: HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 4


name: HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 3


name: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2


name: TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 4


name: MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE


name: TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 6


name: TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 3


name: TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1


name: TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 2


name: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1


name: ENDOGENOUS RETROVIRUS GROUP V MEMBER 1 ENV POLYPROTEIN


name: ENDOGENOUS RETROVIRUS GROUP FC1 ENV POLYPROTEIN-RELATED


name: ENDOGENOUS RETROVIRUS GROUP 3 MEMBER 1 ENV POLYPROTEIN


name: HERV-H_2Q24.1 PROVIRUS ANCESTRAL ENV POLYPROTEIN-RELATED


name: ENDOGENOUS RETROVIRUS GROUP V MEMBER 2 ENV POLYPROTEIN


name: ENDOGENOUS RETROVIRAL ENVELOPE PROTEIN HEMO


name: ENDOGENOUS RETROVIRUS GROUP PABLB MEMBER 1 ENV POLYPROTEIN


name: ENDOGENOUS RETROVIRUS GROUP S71 MEMBER 1 ENV POLYPROTEIN


name: syncytium formation by plasma membrane fusion

description: The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.


syncytium formation

description: The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division.


cell-cell fusion

description: A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium.


M band

description: The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.


name: NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 2


name: NUCLEAR RECEPTOR SUBFAMILY 2 GROUP E MEMBER 1


name: NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 1


name: NUCLEAR RECEPTOR SUBFAMILY 2 GROUP F MEMBER 6


name: PYRIDOXAL-DEPENDENT DECARBOXYLASE DOMAIN-CONTAINING PROTEIN 1-RELATED


heparin binding

description: Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.


name: 85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2


name: POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 1


name: CBP80_20-DEPENDENT TRANSLATION INITIATION FACTOR


name: GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL


name: ANDROGEN INDUCED INHIBITOR OF PROLIFERATION  AS3  / PDS5-RELATED


name: SISTER CHROMATID COHESION PROTEIN PDS5 HOMOLOG B


name: SISTER CHROMATID COHESION PROTEIN PDS5 HOMOLOG A


mitotic sister chromatid cohesion

description: The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.


sister chromatid cohesion

description: The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.


name: EXOCYST COMPLEX COMPONENT 3-LIKE PROTEIN


name: TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 2


name: EXOCYST COMPLEX COMPONENT 3-LIKE PROTEIN 4


name: CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19


name: CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 16


name: CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 7


name: CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 3


name: CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 4


name: CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 20


name: CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1


name: V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE


name: FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 8


mitochondrial RNA metabolic process

description: The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.


mitochondrial RNA processing

description: The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion.


name: TELOMERE REPEATS-BINDING BOUQUET FORMATION PROTEIN 2


telomere localization

description: Any process in which a telomere is transported to, and/or maintained in, a specific location.


name: DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1


cis-Golgi network

description: The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.


name: GLUTATHIONE HYDROLASE 1 PROENZYME-RELATED


name: U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10


name: SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL


name: COMPLEX I ASSEMBLY FACTOR ACAD9, MITOCHONDRIAL


name: VERY LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL


name: CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157


name: METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN


name: MESODERM INDUCTION EARLY RESPONSE PROTEIN 1


name: MESODERM INDUCTION EARLY RESPONSE PROTEIN 3


name: MESODERM INDUCTION EARLY RESPONSE PROTEIN 2


name: CELL FATE DETERMINING PROTEIN MAB21-RELATED


name: INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN-LIKE 2


name: INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN


name: INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN-LIKE 1


name: negative regulation of double-strand break repair via homologous recombination

description: Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination.


negative regulation of DNA repair

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.


name: regulation of double-strand break repair via homologous recombination

description: Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.


name: negative regulation of DNA recombination

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.


name: negative regulation of double-strand break repair

description: Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair.


name: LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G6F


name: LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G6D


name: acetylcholine receptor regulator activity

description: Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed.


name: NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL


name: CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 3


phosphatidylserine binding

description: Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.


name: FHF COMPLEX SUBUNIT HOOK-INTERACTING PROTEIN 1B


name: FHF COMPLEX SUBUNIT HOOK-INTERACTING PROTEIN 1A


name: FHF COMPLEX SUBUNIT HOOK INTERACTING PROTEIN 2A


name: FHF COMPLEX SUBUNIT HOOK-INTERACTING PROTEIN 2B


name: early endosome to late endosome transport

description: The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.


name: NUCLEAR MITOTIC APPARATUS PROTEIN 1-RELATED


name: GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2


ciliary transition fiber

description: A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium).


name: VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7


name: CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT


name: NEURONAL PAS DOMAIN-CONTAINING PROTEIN 2


name: UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER


name: UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1


name: U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN


name: U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN


histone deacetylase activity

description: Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.


name: E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED


name: PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN


name: SOLUBLE LAMIN-ASSOCIATED PROTEIN OF 75 KDA


name: ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7


name: ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 2


name: ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 1


name: ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 5


name: ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6


name: ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4


name: ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 3


name: SPECKLE TARGETED PIP5K1A-REGULATED POLY(A) POLYMERASE


name: 28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL


name: ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4


name: V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE 2


name: V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10


name: CYCLIN-DEPENDENT KINASE INHIBITOR 1-RELATED


protein kinase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a protein kinase.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.


name: ATP-DEPENDENT RNA HELICASE DDX49-RELATED


name: ATP-DEPENDENT RNA HELICASE DDX10-RELATED


name: ATP-DEPENDENT RNA HELICASE DDX28-RELATED


name: ATP-DEPENDENT RNA HELICASE DDX52-RELATED


name: ATP-DEPENDENT RNA HELICASE DDX46-RELATED


name: ATP-DEPENDENT RNA HELICASE DDX27-RELATED


name: ATP-DEPENDENT RNA HELICASE DDX31-RELATED


name: ATP-DEPENDENT RNA HELICASE DDX56-RELATED


name: ATP-DEPENDENT RNA HELICASE DDX47-RELATED


name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.


cytoplasmic translational initiation

description: The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.


name: WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1


name: CELL DIVISION CYCLE 20  CDC20   FIZZY -RELATED


name: CELL DIVISION CYCLE PROTEIN 20 HOMOLOG B


name: GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-4


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-3


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-5-RELATED


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-11


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-7


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-2


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT GAMMA-T1


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-10


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-14-RELATED


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-8


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-T2


name: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-12


name: APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL


name: BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN


name: LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR  LZF1


name: EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN


name: EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8


name: EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 3


name: EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 1


name: EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 2


protein folding chaperone complex

description: A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins.


name: NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 1


name: NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 2


name: NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 3


nuclear receptor binding

description: Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand.


name: CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL


name: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6


phagolysosome assembly

description: The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.


name: RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A 1


name: RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A 2


name: COILED-COIL DOMAIN-CONTAINING PROTEIN 187


name: SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 2


name: CENTRIOLAR SATELLITE-ASSOCIATED TUBULIN POLYGLUTAMYLASE COMPLEX REGULATOR 1


name: TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG


name: PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR-ASSOCIATED PROTEIN 1


name: SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D


name: SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 3


name: SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 1


name: SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 2


name: CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE


name: 5-AMINOLEVULINATE SYNTHASE, ERYTHROID-SPECIFIC, MITOCHONDRIAL


name: 5-AMINOLEVULINATE SYNTHASE, NON-SPECIFIC, MITOCHONDRIAL


name: 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL


heme biosynthetic process

description: The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.


pigment biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin.


name: EGF-CONTAINING FIBULIN-LIKE EXTRACELLULAR MATRIX PROTEIN 1


name: DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 2-RELATED


name: DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 3-ALPHA


name: DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 3-BETA


name: DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 1


name: TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 2


developmental pigmentation

description: The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.


name: NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1  NDUFV1


name: NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL


name: MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22


name: MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG


replisome

description: A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.


nuclear replication fork

description: The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.


DNA-directed DNA polymerase activity

description: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.


DNA polymerase activity

description: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group.


name: FAMILY WITH SEQUENCE SIMILARITY 90 MEMBER A11, PSEUDOGENE-RELATED


name: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B


tumor necrosis factor binding

description: Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.


name: TELOMERE REPEATS-BINDING BOUQUET FORMATION PROTEIN 1


name: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1


negative regulation of nuclear division

description: Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.


name: ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 13


name: KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI


name: KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 2


name: KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 1


name: KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 3


name: ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 1


name: ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 12-RELATED


name: ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10


name: ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 8


name: G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4


name: G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2


name: G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3


name: ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 14


name: ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 11


name: ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 15


name: G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1


name: DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR  DMRT


name: DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR C2


name: DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR C1


name: DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR A2


name: DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR 2


name: DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR A1