name: Stage IVB Sinonasal Squamous Cell Carcinoma AJCC v7

description: Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Adenocarcinoma of salivary gland

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: An adenocarcinoma arising from the salivary gland.  It includes the salivary gland polymorphous low grade adenocarcinoma, salivary gland oncocytic carcinoma, salivary gland mucinous adenocarcinoma, salivary gland low grade cribriform cystadenocarcinoma, salivary gland cystadenocarcinoma, salivary gland basal cell adenocarcinoma, salivary gland acinic cell carcinoma, salivary duct carcinoma, and salivary gland adenocarcinoma not otherwise specified.


name: Recurrent Minor Salivary Gland Adenocarcinoma

description: The reemergence of minor salivary gland adenocarcinoma after a period of remission.


Stage IV Nasal Cavity Cancer

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


name: Stage IVB Paranasal Sinus Cancer AJCC v7


name: Stage II Paranasal Sinus Cancer AJCC v6 and v7

description: Stage II includes: T2, N0, M0.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage III Nasal Cavity and Paranasal Sinus Cancer AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Squamous cell carcinoma of the oral cavity stage II

description: Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage III Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Sinonasal Small Cell Neuroendocrine Carcinoma

description: A very rare small cell neuroendocrine carcinoma that arises from the nose and paranasal sinuses.


name: Squamous cell carcinoma of the oral cavity stage III


name: ASPH-Positive Head and Neck Squamous Cell Carcinoma

description: A head and neck squamous cell carcinoma in which the malignant cells are positive for ASPH gene.


name: Salivary Gland Hyalinizing Clear Cell Carcinoma

description: A rare, slow-growing carcinoma that arises from the salivary glands, usually the minor salivary glands of the oral cavity. It is composed of malignant clear and eosinophilic cells in a hyalinized stroma. Most cases are associated with translocation of EWSR1 and ATF1, resulting in the formation of EWSR1-ATF1 fusion gene. The prognosis is good.


name: Salivary Gland High Grade Adenocarcinoma, Not Otherwise Specified

description: A salivary gland adenocarcinoma, not otherwise specified, characterized by the presence of high-grade morphological features.


name: Sinonasal Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the mucosal epithelium of the nasal cavity or the paranasal sinuses and is characterized by prominent production of keratin.


name: Stage IVC Nasal Cavity and Paranasal Sinus Cancer AJCC v8

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Stage II Nasal Cavity and Paranasal Sinus Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates. Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Sinonasal Lymphoepithelial Carcinoma

description: A nonkeratinizing squamous cell carcinoma arising from the sinonasal tract. It is characterized by the presence of large cells with vesicular nuclei and prominent nucleoli, a syncytial growth pattern, and a lymphoplasmacytic infiltrate.


name: Stage I Oral Cavity Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

description: Stage IV includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (Any T, N3, M0); (T4, Any N, M0); (Any T, Any N, M1). T1: Tumor smaller than 2 cm in greatest dimension. T2: Tumor 2 cm or larger, but smaller than 4 cm in greatest dimension. T3: Tumor 4 cm or larger in greatest dimension or minor bone erosion or perineural invasion or deep invasion. Deep invasion is defined as invasion beyond the subcutaneous fat or larger than 6 mm; perineural invasion for T3 classification is defined as tumor cells within the nerve sheath of a nerve lying deeper than the dermis or measuring 0.1 mm or larger in caliber, or presenting with clinical or radiographic involvement of named nerves without skull base invasion or transgression. T4: Tumor with gross cortical bone/marrow, skull base invasion and/or skull base foramen invasion. N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-).  N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral lymph nodes, any with ENE(+). M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Sellar Choriocarcinoma

description: A choriocarcinoma that arises from or adjacent to the sellar region.


name: Stage II Lip and Oral Cavity Cancer AJCC v6 and v7


name: Salivary Gland Microsecretory Adenocarcinoma

description: A rare, low-grade adenocarcinoma that arises from the salivary gland. Almost all cases have been described in the oral cavity. It is characterized by a microcystic growth pattern, uniform intercalated duct-like tumor cells, basophilic luminal secretions, and fibromyxoid stroma formation. It is associated with MEF2C-SS18 fusion gene expression.


Recurrent Salivary Gland Adenocarcinoma

description: The reemergence of salivary gland adenocarcinoma after a period of remission.


Locally Advanced Oral Cavity Carcinoma

description: Oral cavity carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IVA Lip Cancer AJCC v6 and v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Lip cancer with moderately advanced local disease.  Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose.  T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


name: Minor Salivary Gland Mucoepidermoid Carcinoma

description: A carcinoma that arises from the minor salivary glands.  It usually presents as a firm and painless mass.  It is characterized by the presence of epidermoid cells, mucus producing cells, and cells of intermediate type.  The majority of cases have a favorable outcome.


description: An SWI/SNF-deficient sinonasal carcinoma characterized by inactivating mutation of SMARCB1 gene. It usually affects the nasal sinuses. It is composed of malignant epithelial cells with a predominantly oncocytoid/plasmacytoid morphology and prominent glandular formations.


name: Stage IV Lip and Oral Cavity Cancer AJCC v8

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone or involves the inferior alveolar nerve, floor of mouth, or skin of face (i.e., chin or nose).  T4a (oral cavity): Tumor invades adjacent structures only (e.g., through cortical bone of the mandible or maxilla, or involves the maxillary sinus or skin of face). Note: Superficial erosion of bone/tooth socket (alone) by a gingival primary is not sufficient to classify a tumor as T4. T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less DOI. T2: Tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI. T3: Tumor size greater than 4 cm or any tumor greater than 10 mm DOI. T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases the internal carotid artery. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or larger than 3 cm but not larger than 6 cm in greatest dimension and ENE (-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension, ENE(-). N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE (-); or in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral or bilateral lymph nodes any with ENE(+). M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th Ed.)


Anterior Tongue Carcinoma

description: A carcinoma that arises from the anterior two-thirds of the tongue.  Representative examples include squamous cell carcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.


name: Salivary Gland Poorly Differentiated Squamous Cell Carcinoma

description: A poorly differentiated squamous cell carcinoma arising from the salivary gland.


name: Locally Advanced Sinonasal Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the nasal cavity and/or paranasal sinuses and has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage III Paranasal Sinus Cancer AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Adenoid cystic carcinoma of the oral cavity stage IV


Salivary Gland Clear Cell Carcinoma

description: A carcinoma that arises from the salivary glands, most often the minor salivary glands.  It is characterized by the presence of a monomorphic population of malignant epithelial cells with clear cytoplasm and the absence of morphologic features that define other primary neoplasms of the salivary glands.


name: Locally Recurrent Oral Cavity Squamous Cell Carcinoma

description: The reemergence of oral cavity squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


name: Unresectable Salivary Gland Squamous Cell Carcinoma

description: Salivary gland squamous cell carcinoma that is not amenable to surgical resection.


name: Stage II Nasal Cavity and Paranasal Sinus Cancer AJCC v6 and v7

description: Stage II includes: T2, N0, M0.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th ed.)


Anterior Tongue Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the anterior two-thirds of the tongue.  It usually presents as a painful ulcerated or nodular lesion.


name: Sinonasal Adenocarcinoma, Intestinal-Type with Colonic Pattern

description: An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a tubuloglandular growth pattern.


name: Stage IV Nasal Cavity and Paranasal Sinus Cancer AJCC v8

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1). T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses. Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses. T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve (V2), nasopharynx, or clivus. T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone. Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion. T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates. Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes , none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral or bilateral nodes, any with ENE(+). M0: No distant metastasis. M1: Distant metastasis.  (AJCC 8th ed.)


name: Stage IVC Lip and Oral Cavity Cancer AJCC v6 and v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


name: Ameloblastic Carcinoma-Secondary Type (Dedifferentiated)

description: A very rare ameloblastic carcinoma that originates from a pre-existing benign ameloblastoma.


name: Stage IVB Nasal Cavity and Paranasal Sinus Cancer AJCC v8

description: Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0). T4b: Very advanced local disease. Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve (V2), nasopharynx, or clivus. N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral or bilateral nodes, any with ENE(+). M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Lip Carcinoma

description: A carcinoma that arises from the lip and has metastasized to another anatomic site.


name: Adenoid cystic carcinoma of the oral cavity stage I

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Minor Salivary Gland Undifferentiated Carcinoma

description: A carcinoma that affects the minor salivary glands and is characterized by the presence of undifferentiated, anaplastic malignant epithelial cells.


name: lymphoepithelial squamous cell carcinoma of salivary gland

description: A rare carcinoma that arises from the salivary glands, most often the parotid gland.  It is characterized by the presence of an undifferentiated carcinomatous component associated with a prominent reactive lymphoplasmacytic infiltrate.


cystadenocarcinoma of salivary gland

description: A rare, low-grade adenocarcinoma that arises from the salivary glands.  It presents as a slow growing asymptomatic mass and is characterized by the presence of multiple cystic spaces.


name: Human Papillomavirus-Related Mucosal Head and Neck Squamous Cell Carcinoma

description: A squamous cell carcinoma associated with human papilloma virus, arising from the mucosal sites of head and neck.


name: Salivary Gland Adenocarcinoma, Not Otherwise Specified

description: An adenocarcinoma that arises from the salivary glands.  It exhibits ductal differentiation but lacks any of the morphologic features that characterize the other well-defined primary adenocarcinomas of the salivary glands.


name: Metastatic Sinonasal Squamous Cell Carcinoma

description: Nasal cavity and/or paranasal sinus squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


name: Mucoepidermoid carcinoma of the oral cavity stage II

description: Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Sinonasal Adenocarcinoma, Intestinal-Type with Solid Pattern

description: An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a solid growth pattern.


Alveolar Ridge Squamous Cell Carcinoma

description: Squamous cell carcinoma arising from the upper or lower alveolar ridge.


name: Unresectable Head and Neck Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the head and neck region and is not amenable to surgical resection.


High Grade Salivary Gland Carcinoma

description: A usually aggressive salivary gland carcinoma with high-grade histopathologic features.  It includes the salivary duct carcinoma, salivary gland oncocytic carcinoma, and high grade salivary gland mucoepidermoid carcinoma.


name: Salivary Gland Polymorphous Adenocarcinoma, Conventional Subtype

description: A salivary gland polymorphous adenocarcinoma characterized by the presence of uniform malignant cells with scant cytoplasm forming trabecular, tubular, microcystic, solid, and papillary-cystic patterns. The tumor stroma can be mucinous, myxoid, or hyalinized. Perineural involvement is often seen.


name: Ameloblastic Carcinoma-Secondary Type (Dedifferentiated), Peripheral

description: A very rare ameloblastic carcinoma that originates from a pre-existing extraosseous benign ameloblastoma.


name: Recurrent Salivary Gland Adenocarcinoma, Not Otherwise Specified

description: The reemergence of salivary gland adenocarcinoma, not otherwise specified after a period of remission.


name: Stage IVC Lip and Oral Cavity Cancer AJCC v8

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th Ed.)


Stage IV Lip Cancer AJCC v6 and v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose.  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


name: Stage III Nasal Cavity and Paranasal Sinus Cancer AJCC v8

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone. Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion. T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates. Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


Head and Neck Basaloid Carcinoma

description: A high-grade, aggressive variant of squamous cell carcinoma that arises from the head and neck region.  The most common sites of origin are pyriform sinus, epiglottis, and base of tongue.  It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading.  Comedonecrosis may be present.


name: Metastatic Oral Cavity Adenoid Cystic Carcinoma

description: An adenoid cystic carcinoma that arises from the oral cavity and has metastasized to another anatomic site.


name: Stage 0 Paranasal Sinus Cancer AJCC v6, v7, and v8

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th, 7th, and 8th eds.)


name: Metastatic Salivary Gland Adenocarcinoma, Not Otherwise Specified

description: Salivary gland adenocarcinoma, not otherwise specified that has spread from its original site of growth to another anatomic site.


Salivary Gland Myoepithelial Carcinoma

description: A locally aggressive carcinoma that arises from the salivary glands, predominantly the parotid gland. It is characterized by the presence of a malignant cellular infiltrate exhibiting myoepithelial differentiation. Patients usually present with a painless mass.


name: Stage 0 Sinonasal Cancer AJCC v6, v7, and v8


name: Posterior Tongue Mucoepidermoid Carcinoma

description: A mucoepidermoid carcinoma arising from the minor salivary glands in the base of the tongue.


name: Stage IVC Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Mucoepidermoid carcinoma of the tongue

description: A mucoepidermoid carcinoma that arises from the tongue.


Odontogenic Carcinoma

description: A carcinoma that arises from tooth-forming tissues.


Palate carcinoma

description: A carcinoma that arises from the hard or soft palate.  Representative examples include squamous cell carcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.


name: Squamous cell carcinoma of the oral cavity recurrent

description: Reemergence of squamous cell carcinoma of the oral cavity after a period of remission.


name: Stage III Sinonasal Squamous Cell Carcinoma AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal Cancer by AJCC v7 Stage

description: A term that refers to the staging of nasal cavity and paranasal sinus carcinoma according to the American Joint Committee on Cancer, 7th edition.


Stage III Lip Cancer AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Salivary Gland Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the salivary glands. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


name: Stage IVA Nasal Cavity and Paranasal Sinus Cancer AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage III Lip and Oral Cavity Cancer AJCC v8

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor size greater than 4 cm or any tumor greater than 10 mm DOI. T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less DOI. T2: Tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE (extranodal extension)(-). M0: No distant metastasis. (AJCC 8th Ed.)


name: Recurrent Salivary Gland Squamous Cell Carcinoma

description: The reemergence of salivary gland squamous cell carcinoma after a period of remission.


name: Cribriform Adenocarcinoma of Minor Salivary Gland

description: A minor salivary gland adenocarcinoma characterized by a cribriform pattern. It often metastasizes to the neck lymph nodes.


Refractory Salivary Gland Carcinoma

description: Salivary gland carcinoma that is resistant to treatment.


Salivary Gland Intraductal Carcinoma

description: A rare, low-grade adenocarcinoma that arises from the salivary glands.  It is characterized by the presence of cystic structures lined by ductal cells which are arranged in cribriform patterns.  Adjacent ducts show intraductal proliferation.


name: Stage IVC Paranasal Sinus Cancer AJCC v7

description: Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


name: Stage I Nasal Cavity and Paranasal Sinus Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Locally Advanced Head and Neck Carcinoma

description: A head and neck carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Recurrent Head and Neck Squamous Cell Carcinoma

description: The reemergence of squamous cell carcinoma in the head and neck region after a period of remission.


name: basaloid squamous cell carcinoma of floor of mouth

description: An aggressive variant of squamous cell carcinoma that arises from the floor of the mouth. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading.


name: Primary Intraosseous Squamous Cell Carcinoma Derived From Odontogenic Cyst

description: A rare primary intraosseous carcinoma, not otherwise specified, that arises from the lining of an odontogenic cyst.


name: large cell neuroendocrine carcinoma of salivary gland

description: A large cell carcinoma that arises from the salivary glands and exhibits neuroendocrine differentiation.


name: Stage IV Nasal Cavity and Paranasal Sinus Cancer AJCC v7

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


Head and Neck Neuroendocrine Carcinoma

description: A rare neuroendocrine carcinoma that arises from the head and neck.


name: Mucoepidermoid carcinoma of the oral cavity stage I

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Clear cell odontogenic carcinoma

description: A usually aggressive malignant neoplasm arising from tooth-forming tissues. It more often affects older females and more frequently occurs in the mandible. It is characterized by the presence of malignant epithelial cells with clear cytoplasm and a fibrotic stroma formation. It may recur and metastasize. Metastases may occur in the lymph nodes, lungs, and bones. Treatment of choice is resection with clean margins.


name: Sinonasal Adenocarcinoma, Intestinal-Type with Mucinous Pattern

description: An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of malignant glandular cells with intracytoplasmic mucin.


Primary ameloblastic carcinoma

description: A rare, aggressive odontogenic malignant tumor that arises usually from the mandible and less frequently from the maxilla.  It combines the histologic features of an ameloblastoma and carcinoma.


name: Mucoepidermoid carcinoma of the oral cavity stage III

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Lip and Oral Cavity Cancer by AJCC v8 Stage

description: A term that refers to the staging of lip and oral cavity carcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Stage III Oral Cavity Cancer AJCC v6 and v7


name: Adenoid cystic carcinoma of the oral cavity

description: An adenoid cystic carcinoma arising from the minor salivary glands in the oral cavity.


name: Stage I Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor smaller than 2 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Salivary Gland Intermediate Grade Adenocarcinoma, Not Otherwise Specified

description: A salivary gland adenocarcinoma, not otherwise specified, characterized by the presence of intermediate-grade morphological features.


name: Polymorphous low grade adenocarcinoma of salivary gland

description: A low grade malignant epithelial neoplasm arising from the salivary gland. It usually arises from the oral cavity, with approximately 60% of the cases involving the palate. The most common presenting sign is a painless mass in the palate. It is characterized by the presence of uniform, small to medium size malignant epithelial cells and an infiltrating pattern. There is a variety of morphologic patterns which may be present within an individual tumor, including lobular, papillary, papillary-cystic, cribriform, and trabecular pattern. It usually has a favorable clinical outcome and a low metastatic potential.


name: Anterior Tongue Mucoepidermoid Carcinoma

description: A mucoepidermoid carcinoma arising from the minor salivary glands in the anterior tongue.


Ear carcinoma

description: A carcinoma that arises from the ear.  Representative examples include ceruminous adenocarcinoma and squamous cell carcinoma of the external ear and adenocarcinoma of the middle ear.


name: Head and Neck Small Cell Neuroendocrine Carcinoma

description: A small cell neuroendocrine carcinoma that arises from the head and neck.


name: Stage IVA Nasal Cavity and Paranasal Sinus Cancer AJCC v8

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses. Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses. T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone. Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion. T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates. Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes , none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


iminium ion

Cations of structure R2C=N(+)R2.


name: Cutaneous Indeterminate Dendritic Cell Histiocytosis

description: A very rare dendritic cell tumor affecting the skin. It is composed of spindle to ovoid cells with a phenotype that is similar to the Langerhans cells. It manifests with cutaneous papules, nodules, and plaques.  The clinical course is variable.


name: Stage III Childhood Non-Rhabdomyosarcoma Soft Tissue Sarcoma by Toronto Guidelines v2

description: T2 or T3 or T4, N0, M0, G2 or G3 or Any T, N1, M0, Any G (G1, G2, G3 or GX). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Seminal Vesicle Angiosarcoma

description: An extremely rare angiosarcoma that affects the seminal vesicle.


name: Head and Neck Extraskeletal Myxoid Chondrosarcoma

description: An extraskeletal myxoid chondrosarcoma that arises from the head and neck. The orbit is the most frequently affected site.


name: Stage IVA Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Uterine corpus endometrial stroma sarcoma with tumor invading bladder or rectum. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Benign fibrohistiocytic neoplasm of skin

description: A benign neoplasm arising from the skin. It is composed of fibrohistiocytic cells, spindle fibroblastic cells, and histiocytes arranged in a storiform pattern.


Childhood Tenosynovial Giant Cell Tumor

description: A tenosynovial giant cell tumor that occurs during childhood.


Vulvar Rhabdomyosarcoma

description: A malignant mesenchymal neoplasm with skeletal muscle differentiation arising from the vulva.


name: Central Nervous System Solitary Fibrous Tumor

description: A mesenchymal, non-meningothelial neoplasm arising from the central nervous system. It is characterized by a collagenous and low cellularity spindle cell and/or hemangiopericytomatous histopathological pattern, recurrent intrachromosomal rearrangement on chromosome 12q that results in the fusion of the NAB2 and STAT6 genes, high recurrence rates, and long-term risk of systemic metastasis.


Extraskeletal osteosarcoma recurrent

description: The reemergence of extraskeletal osteosarcoma after a period of remission.


Digestive System Kaposi Sarcoma

description: A Kaposi sarcoma arising from the digestive system.


Dermatomyofibroma

description: A rare benign cutaneous mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation. (WHO 2018)


Giant Cell Angiofibroma

description: A morphologic variant of angiofibroma characterized by the presence of multinucleated giant cells, collagenous or myxoid stroma, focal sclerotic areas, and angiectoid spaces.


Parotid Gland Nodular Fasciitis

description: A self-limiting, rapidly growing, non-encapsulated benign neoplasm that arises from the parotid gland. It is composed of fibroblastic/myofibroblastic cells.


Esophageal Rhabdomyosarcoma

description: A rhabdomyosarcoma arising from the esophageal wall.


name: Head and Neck Inflammatory Myofibroblastic Tumor

description: An inflammatory myofibroblastic tumor that arises from the head and neck. The most frequently affected sites are the larynx, sinonasal tract, and oral cavity.


name: Resectable Undifferentiated Pleomorphic Sarcoma

description: Undifferentiated pleomorphic sarcoma that is amenable to surgical resection.


name: Childhood Rhabdomyosarcoma by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood rhabdomyosarcoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


name: Localized Childhood Non-Rhabdomyosarcoma Soft Tissue Sarcoma by Toronto Guidelines v2

description: Tumor confined to the area of origin including regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Prostate Osteosarcoma

description: A rare osteosarcoma that arises from the prostate gland.


Oral Cavity Leiomyoma

description: A benign smooth muscle neoplasm arising from the oral cavity. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.


Central Nervous System Myofibroblastoma

description: A rare myofibroblastoma affecting the central nervous system.


name: Gastrointestinal Stromal Tumor of the Gastrointestinal Tract

description: A stromal tumor that originates from the interstitial cells of Cajal. It may involve any part of the gastrointestinal tract. The majority of cases occur in the stomach. Morphologic variants include the epithelioid cell type, spindle cell type, and mixed cell type. Most cases contain KIT- or PDGFRA-activating mutations. Lesions with a diameter greater than 10cm and more than 5 mitotic figures per 50HPF tend to have a more aggressive clinical course. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases.


Esophageal Soft Tissue Neoplasm

description: A benign, intermediate, or malignant mesenchymal neoplasm that arises from the esophagus.


Recurrent Adult Soft Tissue Sarcoma

description: A soft tissue sarcoma occurring in adults that has recurred after a period of remission.


Salivary Gland Nodular Fasciitis

description: A self-limiting, rapidly growing, non-encapsulated benign neoplasm that arises from the salivary glands. It is composed of fibroblastic/myofibroblastic cells. It usually occurs in the parotid gland.


name: Stage II Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8

description: Stage II includes: T3, N0, M0, Low Mitotic Rate. T3: Tumor measuring more than 5 cm but not more than 10 cm. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


name: Uterine Corpus Inflammatory Myofibroblastic Tumor

description: A rare inflammatory myofibroblastic tumor that arises from the uterine corpus.


Cellular angiofibroma

description: A benign mesenchymal neoplasm that usually arises in the superficial soft tissues of the vulva or inguinal and scrotal regions.  It is characterized by the presence of a cellular fibroblastic proliferation in an edematous to fibrous stroma containing numerous vessels.


Localized Soft Tissue Sarcoma

description: A soft tissue sarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


name: Prostate Undifferentiated Pleomorphic Sarcoma

description: A rare undifferentiated pleomorphic sarcoma that arises from the prostate gland.


Head and Neck Leiomyoma

description: A benign neoplasm with smooth muscle differentiation that arises from the head and neck. The most frequently affected site is the oral cavity.


Bladder Alveolar Soft Part Sarcoma

description: An alveolar soft part sarcoma involving the bladder.


Advanced Kaposi Sarcoma

description: Kaposi sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


EBV-Related Sarcoma

description: Sarcoma that is caused by Epstein-Barr virus infection.


name: Benign Central Nervous System Mesenchymal, Non-Meningothelial Neoplasm

description: A mesenchymal, non-meningothelial neoplasm that arises from the central nervous system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Kidney Oncocytoma-Like Angiomyolipoma

description: A rare angiomyolipoma of the kidney characterized by the presence of polygonal cells with eosinophilic cytoplasm.


Seminal Vesicle Soft Tissue Neoplasm

description: A mesenchymal neoplasm that arises from the seminal vesicle.


Stage II Uterine Sarcoma AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Tumor extends beyond the uterus, within the pelvis.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  This staging applies to leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. (AJCC 7th ed.)


name: Stage II Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8

description: Stage II includes: (T1, N0, M0, High Mitotic Rate); (T2, N0, M0, High Mitotic Rate); (T4, N0, M0, Low Mitotic Rate). T1: Tumor measuring 2 cm or less. T2: Tumor measuring more than 2 cm but not more than 5 cm. T4: Tumor measuring more than 10 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. High Mitotic Rate: Over 5 mitoses per 5 square millimeters, or per 50 HPF. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


name: Stage IIB Adult Soft Tissue Sarcoma AJCC v7


name: Plaque-like CD34 positive dermal fibroma

description: A congenital or acquired benign dermal spindle cell neoplasm with histopathological features mimicking those of superficial dermal dermatofibrosarcoma protuberans. (WHO 2018)


name: Metastatic Extraskeletal Myxoid Chondrosarcoma

description: An extraskeletal myxoid chondrosarcoma which has spread to another anatomic site.


Bladder PEComa

description: A benign or malignant perivascular epithelioid cell tumor arising from the bladder.


name: Gastrointestinal Clear Cell Sarcoma/Malignant Gastrointestinal Neuroectodermal Tumor

description: A gastrointestinal tract sarcoma with neuroectodermal differentiation. It is characterized by the presence of neoplastic round cells with pale eosinophilic cytoplasm. Cytoplasmic clearing is seen only in a minority of cases. Half of the cases contain osteoclastic giant cells. It is associated with gene fusion translocations involving the EWSR1 gene, usually EWSR1-ATF1 fusion or EWSR1-CREB1 fusion.


Lacrimal Gland Myoepithelioma

description: A benign neoplasm with myoepithelial differentiation arising from the lacrimal gland. It lacks an infiltrative growth pattern and does not metastasize.


Uterine Corpus Smooth Muscle Neoplasm

description: A benign, intermediate, or malignant neoplasm that arises from the uterine corpus and is composed of neoplastic cells with smooth muscle differentiation.


name: Childhood Desmoplastic Small Round Cell Tumor

description: A desmoplastic small round cell tumor occurring in children.


Malignant ossifying fibromyxoid tumor

description: An ossifying fibromyxoid tumor characterized by the presence of high grade nuclear features or increased cellularity and more than two mitotic figures per 50 HPFs.


Salivary Gland Myoepithelial Tumor

description: A benign or malignant tumor that arises from the salivary glands.  It is characterized by the presence of neoplastic cells with myoepithelial differentiation.  This category includes benign myoepithelioma and myoepithelial carcinoma.


Vulvar Angiosarcoma

description: A rare angiosarcoma that arises from the vulva.


Synovial sarcoma metastatic

description: A synovial sarcoma that has metastasized to other anatomic sites.


Childhood Rhabdomyoma

description: A rhabdomyoma that occurs during childhood.


Childhood Synovial Sarcoma

description: A synovial sarcoma occurring in childhood.


Liver Soft Tissue Neoplasm

description: A benign, intermediate, or malignant mesenchymal neoplasm that arises from the liver and intrahepatic bile ducts.


name: Stage IB Gastric Gastrointestinal Stromal Tumor

description: Stage IB includes: T3, N0, M0, Mitotic rate: Low.  T3: Tumor more than 5 cm, but not more than 10 cm, in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Vulvar Soft Tissue Neoplasm

description: A benign or malignant mesenchymal neoplasm of the vulva.  Representative examples include leiomyoma, cellular angiofibroma, angiomyxoma, leiomyosarcoma, liposarcoma, and childhood botryoid-type embryonal rhabdomyosarcoma.


Advanced Alveolar Soft Part Sarcoma

description: Alveolar soft part sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Gastric Inflammatory Myofibroblastic Tumor

description: A multinodular intermediate fibroblastic neoplasm arising from the stomach.  It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells.


name: Stage III Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8

description: Stage III includes: IIIA: (T1, N0, M0, High Mitotic Rate); (T4, N0, M0, Low Mitotic Rate); IIIB: (T2, N0, M0, High Mitotic Rate); (T3, N0, M0, High Mitotic Rate); (T4, N0, M0, High Mitotic Rate). T1: Tumor measuring 2 cm or less. T2: Tumor measuring more than 2 cm but not more than 5 cm. T3: Tumor measuring more than 5 cm but not more than 10 cm. T4: Tumor measuring more than 10 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. High Mitotic Rate: Over 5 mitoses per 5 square millimeters, or per 50 HPF. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Sinonasal Desmoid Fibromatosis

description: Desmoid fibromatosis that arises from the nasal cavity and paranasal sinuses.


Gastric Synovial Sarcoma

description: A rare synovial sarcoma that arises from the stomach.


name: Cervical Malignant Peripheral Nerve Sheath Tumor

description: A rare malignant neoplasm with nerve sheath differentiation arising from the cervix.


Breast Nodular Fasciitis

description: A self-limiting, rapidly growing, non-encapsulated benign neoplasm that arises from the breast. It has been described in both the subcutis and parenchyma of the breast. It occurs most frequently in the upper-outer quadrant. It is composed of fibroblastic/myofibroblastic cells.


Pilar-Associated Mesenchyme Neoplasm

description: A mesenchymal neoplasm arising from the pilar sheath of the hair follicle.


name: Gastric Malignant Gastrointestinal Stromal Tumor

description: A gastrointestinal stromal tumor arising from the stomach.  It is characterized by large size (diameter greater than 10 cm) or more than 5 mitotic figures per 50 high power fields.


Benign Sinonasal Soft Tissue Neoplasm

description: A mesenchymal neoplasm that arises from the nasal cavity and paranasal sinuses and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Alveolar soft part sarcoma metastatic

description: An alveolar soft part sarcoma which has spread to another anatomic site.


Stage III Soft Tissue Sarcoma AJCC v7

description: Stage III includes: (T2a, T2b, N0, M0, G3); (Any T, N1, M0, Any G).  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  G3: Grade 3.  There is no T2a for the pathologic group. (AJCC 7th ed.)


Fibrous tissue neoplasm of skin

description: A neoplasm arising from the dermis. It is characterized by the presence of neoplastic fibroblasts.


Vulvar Angiomyxoma

description: A deep or superficial angiomyxoma of the vulva.  It may recur following resection.


Stage II Soft Tissue Sarcoma AJCC v7

description: Stage II includes: IIA (T1a, N0, M0, G2, G3); (T1b, N0, M0, G2, G3); IIB (T2a, N0, M0, G2); (T2b, N0, M0, G2).  T1a: Superficial tumor 5 cm or less in greatest dimension.  T1b: Deep tumor 5 cm or less in greatest dimension.  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G2: Grade 2.  G3: Grade 3. (AJCC 7th ed.)


Metastatic Uterine Corpus Sarcoma

description: Uterine corpus sarcoma that has spread from its original site of growth to another anatomic site.


Biphenotypic sinonasal sarcoma

description: A rare, slow-growing, low-grade soft tissue sarcoma arising from the sinonasal tract. It presents with non-specific obstructive nasal symptoms. Morphologically, it is an infiltrative, cellular spindle cell neoplasm. It is associated with rearrangement of the PAX3 gene.


Tongue GLI1-Altered Soft Tissue Tumor

description: A GLI1-altered soft tissue tumor that arises from the tongue.


name: Breast Inflammatory Myofibroblastic Tumor

description: A multinodular intermediate fibroblastic neoplasm arising from the breast.  It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells.


Bladder Benign PEComa

description: A benign perivascular epithelioid cell tumor arising from the bladder.


name: Recurrent Malignant Soft Tissue Neoplasm

description: Reemergence of a malignant soft tissue neoplasm after a period of remission.


name: Sinonasal Undifferentiated Pleomorphic Sarcoma

description: An undifferentiated pleomorphic sarcoma that arises from the nasal cavity and paranasal sinuses.


name: Head and Neck GLI1-Altered Soft Tissue Tumor

description: A GLI1-altered soft tissue tumor that arises from the head and neck. The majority of cases arise from the tongue. Less frequently involved sites include the submandibular gland and soft tissue of neck.


Locally Advanced Soft Tissue Sarcoma

description: Soft tissue sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Digestive System Soft Tissue Neoplasm

description: A benign, intermediate, or malignant mesenchymal neoplasm that arises from the digestive system.


Digestive System Lipoma

description: A lipoma arising from an anatomic site in the digestive system.


Recurrent Ectomesenchymoma

description: The reemergence of ectomesenchymoma after a period of remission.


Prostate Solitary Fibrous Tumor

description: A rare solitary fibrous tumor that arises from the prostate gland.


name: Stage I Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


AIDS-Related Gastric Kaposi Sarcoma

description: A Kaposi sarcoma arising from the stomach in patients who are infected with the human immunodeficiency virus.


Vulvar Kaposi Sarcoma

description: A Kaposi sarcoma arising from the vulva.


Digestive System Leiomyoma

description: A leiomyoma arising from an anatomic site in the digestive system.


Clear-Cell Myomelanocytic Tumors

description: A very rare, usually benign neoplasm with perivascular epithelioid cell differentiation characterized by the presence of clear spindle cells arranged in fascicles and nests that usually affects young girls.  Patients usually present with a painful abdominal mass.


Rhabdomyosarcoma of urinary bladder

description: A malignant mesenchymal neoplasm with skeletal muscle differentiation arising from the bladder.


Vaginal Superficial Myofibroblastoma

description: An uncommon, benign, well circumscribed mesenchymal neoplasm that grows beneath the vaginal epithelium. It is characterized by the presence of cells containing bland ovoid, spindle, or stellate-shaped nuclei in a collagenous stroma.


name: Uterine Corpus Epithelioid Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle tumor of uncertain malignant potential that arises from the uterine corpus and is composed of neoplastic epithelioid cells.


Vaginal Undifferentiated Sarcoma

description: A high grade infiltrating sarcoma that arises from the vagina. It is characterized by the presence of malignant small spindle cells with scant cytoplasm.


Prostate Soft Tissue Neoplasm

description: A mesenchymal neoplasm that arises from the prostate gland.


Unresectable Rhabdomyosarcoma

description: Rhabdomyosarcoma which is not amenable to surgical resection.


name: Stage I Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8

description: Stage I includes: T1 or T2, N0, M0, Low Mitotic Rate. T1: Tumor measuring 2 cm or less. T2: Tumor measuring more than 2 cm but not more than 5 cm. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Childhood Soft Tissue Sarcoma

description: Soft tissue sarcoma occurring in childhood.


name: Atypical Lipomatous Tumor/Well Differentiated Liposarcoma of Deep Soft Tissue

description: An atypical lipomatous tumor/well differentiated liposarcoma that occurs in deep soft tissue.


name: Stage I Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8

description: Stage I includes: IA: (T1 or T2, N0, M0, Low Mitotic Rate); IB: (T3, N0, M0, Low Mitotic Rate). T1: Tumor measuring 2 cm or less. T2: Tumor measuring more than 2 cm but not more than 5 cm. T3: Tumor measuring more than 5 cm but not more than 10 cm. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Sinonasal Sarcoma

description: A sarcoma that arises from the nasal cavity and paranasal sinuses.


Seminal Vesicle Schwannoma

description: A schwannoma that affects the seminal vesicle.


name: Vulvar Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle neoplasm that arises from the vulva and cannot be reliably diagnosed as benign or malignant because of the presence of ambiguous morphologic findings.


Transplant-Related Kaposi Sarcoma

description: A Kaposi sarcoma that arises in a patient with a history of organ transplantation.


Esophageal Fibroma

description: A benign neoplasm arising from the fibrous soft tissue of the esophagus. It is characterized by the presence of spindle-shaped fibroblasts.


Conjunctival Stromal Tumor

description: A rare benign stromal tumor that arises from the bulbar conjunctiva. It is characterized by the presence of myxoid/collagenous stroma, spindle-shaped cells, pseudonuclear inclusions, and multinucleated cells.


Head and Neck Lipoma

description: A benign adipose tissue neoplasm that arises from the head and neck. The most frequently affected sites are the lower lip, buccal mucosa, and tongue.


Recurrent Uterine Corpus Sarcoma

description: The reemergence of uterine corpus sarcoma after a period of remission.


Kaposi's sarcoma, metastatic

description: Kaposi sarcoma that has spread from its original site of growth to another anatomic site.


Sinonasal Leiomyoma

description: A leiomyoma that arises from the nasal cavity and paranasal sinuses.


Locally Advanced Rhabdomyosarcoma

description: Rhabdomyosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Advanced Soft Tissue Sarcoma

description: A sarcoma of soft tissue that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Benign Head and Neck Soft Tissue Neoplasm

description: A non-metastasizing mesenchymal neoplasm that lacks cytological/morphological atypical features and arises from the soft tissue of the head and neck.


Peritoneal Calcifying Fibrous Tumor

description: A benign well-circumscribed lesion arising from the mesentery. It is characterized by the presence of fibroblasts, lymphoplasmacytic infiltrates, collagenous stroma formation, psammoma bodies, and dystrophic calcifications.


Advanced Epithelioid Sarcoma

description: Epithelioid sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage IV Gastric Gastrointestinal Stromal Tumor

description: Stage IV includes: (Any T, N1, M0, Mitotic rate: Any rate); (Any T, Any N, M1, Mitotic rate: Any rate). N1: Regional lymph node metastasis. M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


Skin Syncytial Myoepithelioma

description: A skin myoepithelioma characterized by a solid syncytial growth of ovoid, spindled, or histiocytoid cells. The majority of cases are associated with EWSR1/PBX3 gene fusion.


Undifferentiated spindle cell sarcoma

description: An undifferentiated soft tissue sarcoma characterized by the presence of a malignant spindle cell infiltrate with amphophilic or palely eosinophilic cytoplasm.


Soft Tissue Angiosarcoma

description: An angiosarcoma that arises from the soft tissues, usually in the deep muscles of the lower extremities, retroperitoneum, mediastinum, and mesentery.


Oral Cavity Soft Tissue Sarcoma

description: A soft tissue sarcoma that arises from the oral cavity.


Scrotal Sarcoma

description: A sarcoma involving the scrotum.


name: Childhood Rhabdomyosarcoma by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood rhabdomyosarcoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


name: Metastatic Childhood Non-Rhabdomyosarcoma Soft Tissue Sarcoma by Toronto Guidelines v2

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Recurrent Extraskeletal Myxoid Chondrosarcoma

description: Reemergence of extraskeletal myxoid chondrosarcoma after a period of remission


Refractory PEComa

description: PEComa that is resistant to treatment.


name: Malignant Epithelioid Cell Type Gastrointestinal Stromal Tumor

description: An epithelioid cell type gastrointestinal stromal tumor with an aggressive clinical course.


Kidney Angiosarcoma

description: A rare angiosarcoma arising from the kidney.


name: Skin Fibrous Histiocytoma, Histiocytic Variant

description: A morphologic variant of fibrous histiocytoma of the skin. It is characterized by the presence of xanthomatous fibrohistiocytic cells, giant cells, and hemosiderin deposition.


Desmoplastic fibroma

description: A rare, benign, locally aggressive osteolytic neoplasm. It is characterized by the presence of a rich collagenous stroma and spindle cells with minimal cellular atypia.


name: Uterine Corpus Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle neoplasm that arises from the uterine corpus and cannot be reliably diagnosed as benign or malignant because of the presence of ambiguous morphologic findings.


Esophageal Synovial Sarcoma

description: A synovial sarcoma that affects the esophageal wall.


Salivary Gland Lipoma

description: A lipoma that arises from a salivary gland. It usually occurs in the parotid gland.


Breast Soft Tissue Neoplasm

description: A benign, intermediate, or malignant mesenchymal neoplasm that arises from the breast.


name: Kidney Angiomyolipoma with Epithelial Cysts

description: A rare angiomyolipoma of the kidney characterized by the presence of solid and cystic architectural patterns. The cysts are lined by hobnail epithelial cells.


Broad ligament leiomyoma

description: A leiomyoma that arises from the broad ligament.


name: Stage IIIB Gastric Gastrointestinal Stromal Tumor

description: Stage IIIB includes: T4, N0, M0, Mitotic rate: High. T4: Tumor more than 10 cm in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


GLI1-Altered Soft Tissue Tumor

description: A rare mesenchymal neoplasm of uncertain histogenesis that arises from soft tissue and viscera. It is characterized by the presence of nests and sheets of neoplastic epithelioid cells separated by a rich delicate arborizing vascular network, and GLI1 gene rearrangement. It presents as a slow-growing painless mass. The majority of cases have an indolent clinical course following complete excision. Distant metastases have been reported in a minority of cases.


Benign Skin Fibroblastic Neoplasm

description: A benign neoplasm arising from the dermis. It is characterized by the presence of neoplastic fibroblasts without malignant characteristics.


name: Alveolar soft part sarcoma non-metastatic

description: Alveolar soft part sarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


name: Locally Advanced Undifferentiated Pleomorphic Sarcoma

description: An undifferentiated pleomorphic sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Locally Advanced Desmoplastic Small Round Cell Tumor

description: Desmoplastic small round cell tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Paratesticular Liposarcoma

description: A liposarcoma that arises from the paratesticular region.


Vulvar Lipoblastoma-Like Tumor

description: A benign, well-defined, lobulated, myxoid or gelatinous tumor that arises from the vulva. It shares morphological features with lipoblastoma, myxoid liposarcoma, and spindle cell lipoma. It is characterized by a lobulated growth and is composed of mature adipocytes, lipoblasts, and spindle cells without atypia in a myxoid matrix. DDIT3 and PLAG1 gene rearrangements seen in lipoblastoma and myxoid liposarcoma are not present in this tumor. It can recur infrequently and there are no reports of metastasis.


Recurrent Soft Tissue Sarcoma

description: The reemergence of soft tissue sarcoma after a period of remission.


name: Uterine Corpus Endometrial Stromal and Related Neoplasms

description: A category of benign or malignant mesenchymal neoplasms that arises from the uterine corpus. This category includes the endometrial stromal nodule which is benign and non-invasive, the endometrial stromal sarcoma, and the undifferentiated uterine sarcoma. The endometrial stromal sarcoma is an invasive malignant neoplasm, further subdivided into low grade and high grade endometrial stromal sarcoma. Undifferentiated uterine sarcoma was previously also known as high grade endometrial stromal sarcoma. In 2014, high grade endometrial stromal sarcoma was reclassified and is currently considered a distinct and rare neoplasm. It appears to have a prognosis that falls between low grade endometrial stromal sarcoma and undifferentiated sarcoma.


Childhood Kaposi Sarcoma

description: Kaposi sarcoma that occurs during childhood.


name: Uterine Corpus Tumor Resembling Ovarian Sex Cord Tumor

description: A usually benign neoplasm that arises from the uterine corpus. It resembles ovarian sex cord tumors. It lacks a component of recognizable endometrial stroma and the JAZF1-SUZ12 fusion which is characteristic of the endometrial stromal neoplasms.


Unresectable Alveolar Soft Part Sarcoma

description: Alveolar soft part sarcoma that is not amenable to surgical resection.


name: Stage II Childhood Non-Rhabdomyosarcoma Soft Tissue Sarcoma by Toronto Guidelines v2

description: T1, N0, M0, G2 or G3. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Central Nervous System Dedifferentiated Solitary Fibrous Tumor

description: A central nervous system solitary fibrous tumor characterized by the presence of areas of abrupt transition to high grade sarcoma.


Vulvar Deep (Aggressive) Angiomyxoma

description: A locally infiltrating, non-metastasizing vulvar angiomyxoma.  It may recur following resection.


name: Peritoneal Low Grade Endometrioid Stromal Sarcoma

description: A very rare sarcoma that arises from the peritoneum and is characterized by the presence of cells that resemble endometrial stromal cells.


name: Stage IIIC Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus. T2: Uterine corpus endometrial stroma sarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Unresectable Epithelioid Sarcoma

description: Epithelioid sarcoma that is not amenable to surgical resection.


Oral Cavity Soft Tissue Neoplasm

description: A mesenchymal neoplasm that arises from the oral cavity.


name: Adult Desmoplastic Small Round Cell Tumor

description: A desmoplastic small round cell tumor occurring in adults.


Major Salivary Gland Sarcoma

description: A rare malignant soft tissue neoplasm that arises from the parotid gland, submandibular gland, or sublingual gland.  Representative examples include fibrosarcoma, angiosarcoma, leiomyosarcoma, and Kaposi sarcoma.


name: Childhood Non-Rhabdomyosarcoma Soft Tissue Sarcoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood non-rhabdomyosarcoma soft tissue sarcoma according to the Toronto childhood cancer staging guidelines v2.


name: Childhood Non-Rhabdomyosarcoma Soft Tissue Sarcoma by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood non-rhabdomyosarcoma soft tissue sarcoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


Recurrent Kaposi Sarcoma

description: The reemergence of Kaposi sarcoma after a period of remission.


name: adult extraskeletal myxoid chondrosarcoma

description: An extraskeletal myxoid chondrosarcoma occurring in adults.


Head and Neck Angiosarcoma

description: An angiosarcoma that arises from the head and neck. The most frequently affected sites are the oral cavity, nasal cavity, and maxillary sinus.


Peripheral Intraneural Angiosarcoma

description: A malignant vascular neoplasm arising from the peripheral nerves.


Kidney Classic Angiomyolipoma

description: A benign mesenchymal tumor that arises from the kidney and is composed of mature adipose tissue, thick-walled blood vessels, and epithelioid and spindle smooth muscle cells.


Endemic African Kaposi Sarcoma

description: A Kaposi sarcoma that occurs in adults and children in Equatorial Africa.


Stage IIB Uterine Sarcoma AJCC v7

description: Tumor involves other pelvic tissues.  No regional lymph node or distant metastasis.


name: Localized Childhood Rhabdomyosarcoma by Toronto Guidelines v2

description: Tumor confined to the area of origin including the regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Intermediate Fibrohistiocytic Neoplasm

description: A fibrohistiocytic neoplasm usually affecting younger patients.  It is characterized by an increased risk of local recurrence and a low risk of metastasis.


name: Childhood Rhabdomyosarcoma with Mixed Embryonal and Alveolar Features

description: A mixed rhabdomyosarcoma that occurs in children. The neoplasm is composed of embryonic and alveolar components.  It is characterized by the presence of spindle cells with myoblastic differentiation and a myxoid and a fibrous stroma.


Sinonasal Synovial Sarcoma

description: A synovial sarcoma that arises from the nasal cavity and paranasal sinuses.


Stage IB Soft Tissue Sarcoma AJCC v7

description: Stage IB includes: (T2a, N0, M0, G1, GX); (T2b, N0, M0, G1, GX).  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Grade 1.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Sinonasal Hemangioma

description: A hemangioma that arises from the nasal cavity and paranasal sinuses.


name: Benign Epithelioid Cell Type Gastrointestinal Stromal Tumor

description: An epithelioid cell type gastrointestinal stromal tumor with an indolent clinical course.


name: Benign Extraskeletal Cartilaginous and Osseous Neoplasm

description: A benign mesenchymal neoplasm with cartilaginous or osseous differentiation arising from the soft tissues exclusively.  Representative examples include chondroma and osteoma.


Unresectable Uterine Corpus Sarcoma

description: Uterine corpus sarcoma that is not amenable to surgical resection.


Low Grade Endometrial Stromal Sarcoma

description: An infiltrating mesenchymal tumor arising from the uterine corpus, cervix, vagina, and the ovary. It is characterized by the presence of oval to spindle-shape cells that resemble the cells of the endometrial stroma, without evidence of significant atypia and pleomorphism. Numerous small vessels are also present. It is usually characterized by indolent growth and late recurrences.


Vulvar Epithelioid Sarcoma

description: An epithelioid sarcoma that arises from the vulva.


name: Central Nervous System Solitary Fibrous Tumor, Grade 2

description: A solitary fibrous tumor that arises from the central nervous system. It corresponds to the more cellular, less collagenous tumor with plump cells and staghorn vasculature which was diagnosed as central nervous system hemangiopericytoma in the past.


High Grade Paranasal Sinus Sarcoma

description: An aggressive malignant soft tissue neoplasm that arises from the paranasal sinus.  It is characterized by the presence of high-grade histologic features.


Childhood Myoepithelial Tumor

description: A myoepithelial tumor that occurs during childhood.


name: Locally Advanced Unresectable Soft Tissue Sarcoma

description: A soft tissue sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Head and Neck Undifferentiated Pleomorphic Sarcoma

description: An undifferentiated pleomorphic sarcoma that arises from the head and neck region.


Vulvar Cellular Angiofibroma

description: A benign neoplasm arising from the fibrous tissue of the vulva. It is characterized by the presence of spindle-shaped fibroblasts, numerous dilated vascular channels, and increased cellularity.


Virus-Related Sarcoma

description: A sarcoma that is caused by a virus.


Visceral Angiosarcoma

description: A soft tissue angiosarcoma arising from the internal organs.


name: Stage IA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8

description: Stage IA includes: T1, N0, M0, G1, GX. T1: Tumor measuring 5 cm or less in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Total differentiation, mitotic count and necrosis score of 2 or 3. (AJCC 8th ed.)


Soft Tissue Sarcoma by AJCC v8 Stage

description: A term that refers to the staging of soft tissue sarcoma, following the rules of the TNM AJCC v8 classification system.


Angiofibroma of soft tissue

description: A benign fibroblastic neoplasm composed of uniform spindle cells with abundant fibromyxoid stroma and a prominent network of innumerable branching, thin-walled blood vessels. It typically arises in the extremities, mainly the legs, frequently involving or adjacent to large joints such as the knee. Unusual anatomical locations include the back, abdominal wall, pelvic cavity, and breast. The tumors are often subcutaneous but may be intramuscular and deep. The lesion presents most often as a slow-growing painless mass. (WHO 2020)


name: Thyroid Gland Malignant Peripheral Nerve Sheath Tumor

description: A rare malignant peripheral nerve sheath tumor that arises from the thyroid gland.


Conjunctival Sarcoma

description: A sarcoma that arises from the conjunctiva.


name: Stroma-Derived Neoplasm of Lymphoid Tissues

description: A group of mesenchymal neoplasms that arise from the lymph node and spleen.


description: Osteosarcoma that arises from the soft tissue and is confined to a specific site without evidence of spread to other anatomic sites.


name: Childhood Inflammatory Myofibroblastic Tumor

description: An inflammatory myofibroblastic tumor that occurs during childhood.


Laryngeal Soft Tissue Neoplasm

description: A mesenchymal neoplasm that arises from the larynx.


Skin Pleomorphic Lipoma

description: A pleomorphic lipoma arising from the skin.


Prostate Synovial Sarcoma

description: A rare synovial sarcoma that arises from the prostate gland.


name: Uterine Corpus Low Grade Endometrial Stromal Sarcoma

description: A rare, indolent, invasive mesenchymal tumor that arises from the endometrial stroma. It is characterized by the presence of a plexiform vasculature, infrequent mitoses, and insignificant cytologic atypia. Late recurrences may occur.


name: Malignant fibrous histiocytoma metastatic

description: An undifferentiated pleomorphic sarcoma that has spread to other anatomic sites.


Bone Leiomyoma

description: A rare leiomyoma affecting the bone.


name: Locally Advanced Alveolar Soft Part Sarcoma

description: Alveolar soft part sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Digestive System Rhabdomyosarcoma

description: A rhabdomyosarcoma arising from an anatomic site in the digestive system.


Skin Soft Tissue Neoplasm

description: A mesenchymal neoplasm that arises from the skin.


Mammary-Type Myofibroblastoma

description: A benign mesenchymal neoplasm characterized by the presence of spindle shaped myofibroblasts and mast cells in a collagenous stroma.  It is histologically identical to the myofibroblastoma of breast.  It usually arises from the subcutaneous tissue and the most common sites of involvement are the inguinal/groin, paratesticular, and vulvovaginal areas.


Dermal Fibroma

description: A benign neoplasm arising from the dermis. It is characterized by the presence of spindle-shaped fibroblasts.


Periosteal fibroma

description: A benign fibrous neoplasm arising from the periosteal connective tissue that surrounds a bone.


Metastatic Soft Tissue Sarcoma

description: Soft tissue sarcoma that has spread from the original site of growth to another anatomic site.


Stage I Soft Tissue Sarcoma AJCC v7

description: Stage I includes: IA (T1a, N0, M0, G1, GX); (T1b, N0, M0, G1, GX); IB (T2a, N0, M0, G1, GX); (T2b, N0, M0, G1, GX).  T1a: Superficial tumor 5 cm or less in greatest dimension.  T1b: Deep tumor 5 cm or less in greatest dimension.  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Grade 1.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Sinonasal glomangiopericytoma

description: A sinonasal soft tissue neoplasm with hemangiopericytoma-like features.


name: Stage III Adult Soft Tissue Sarcoma AJCC v7


alveolar rhabdomyosarcoma of bladder

description: An alveolar rhabdomyosarcoma arising from the bladder. It is the most common type of rhabdomyosarcoma of the bladder affecting older children and adolescents.


name: Stage IIIA Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8

description: Stage IIIA includes: T3, N0, M0, High Mitotic Rate. T3: Tumor measuring more than 5 cm but not more than 10 cm. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. High Mitotic Rate: Over 5 mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


name: Stage IIIA Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues at one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Recurrent Rhabdomyosarcoma

description: The reemergence of rhabdomyosarcoma after a period of remission.


Low Grade Paranasal Sinus Sarcoma

description: A malignant soft tissue neoplasm that arises from the paranasal sinus.  It is characterized by the presence of low-grade histologic features.


Locally Advanced Epithelioid Sarcoma

description: Epithelioid sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Vaginal Soft Tissue Neoplasm

description: A benign or malignant mesenchymal neoplasm that arises from the vagina.  Representative examples include leiomyoma, rhabdomyoma, leiomyosarcoma, endometrioid stromal sarcoma, and botryoid-type embryonal rhabdomyosarcoma.


name: Sinonasal Smooth Muscle Tumor of Uncertain Malignant Potential

description: A rare smooth muscle tumor of uncertain malignant potential that arises from the sinonasal tract.


Unresectable Desmoid Fibromatosis

description: Desmoid fibromatosis that is not amenable to surgical resection.


Parotid Gland Liposarcoma

description: A liposarcoma that arises from the parotid gland.


Laryngeal Soft Tissue Sarcoma

description: A sarcoma that arises from soft tissue of the larynx.


Adult Soft Tissue Sarcoma

description: Soft tissue sarcoma occurring in adults.


Benign Uterine Corpus PEComa

description: A benign neoplasm with perivascular epithelioid cell differentiation arising from the uterine corpus. It is characterized by the absence of pleomorphism and scarcity or absence of mitotic figures. It usually affects perimenopausal women. Patients present with a pelvic mass or abnormal bleeding.


name: Stage IA Adult Soft Tissue Sarcoma AJCC v7


Refractory Malignant Myoepithelioma

description: A malignant myoepithelioma that does not respond to treatment.


Hemosiderotic fibrolipomatous tumor

description: A non-encapsulated, slow-growing, locally aggressive subcutaneous tumor characterized by the presence of adipocytes, hemosiderin-laden spindle cells, hemosiderin-laden macrophages, osteoclast-like giant cells, and scattered chronic inflammatory cells. It usually arises from the dorsum of the foot, ankle, dorsum of the hand, thigh, calf, or cheek.  It may recur if it is not completely excised but does not metastasize.


name: Central Nervous System Undifferentiated Pleomorphic Sarcoma

description: A rare undifferentiated pleomorphic sarcoma (formerly known as malignant fibrous histiocytoma) involving the central nervous system.


name: Uterine Corpus Myxoid Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle tumor of uncertain malignant potential that arises from the uterine corpus and displays myxoid changes.


Localized Childhood Rhabdomyosarcoma

description: Rhabdomyosarcoma that occurs during childhood and is confined to a specific site without evidence of spread to other anatomic sites.


Tumor of Specialized Prostatic Stroma

description: A rare neoplasm arising from specialized prostatic stroma.  This category includes prostatic stromal proliferations of uncertain malignant potential and prostatic stromal sarcomas.


Paratesticular Soft Tissue Neoplasm

description: A mesenchymal neoplasm that arises from the paratesticular region.


Vulvar Distal-Type Epithelioid Sarcoma

description: A rare epithelioid sarcoma of the distal type that arises from the vulva.


Adult Synovial Sarcoma

description: A synovial sarcoma occurring in adults.


name: Non-Metastatic Childhood Soft Tissue Sarcoma

description: A soft tissue sarcoma that occurs during childhood and is confined to a specific site without evidence of spread to other anatomic sites.


name: Childhood Rhabdomyosarcoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood rhabdomyosarcoma according to the Toronto childhood cancer staging guidelines v2.


Fibrous papule of nose

description: An angiofibroma that arises from the nose. It is found in adults as a solitary, dome-shaped papule on the nose.


Vaginal Solitary Fibrous Tumor

description: A rare solitary fibrous tumor that arises from the vagina.


name: Stage IV Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8

description: Stage IV includes: (Any T, N1, M0, Any Mitotic Rate); (Any T, Any N, M1, Any Mitotic Rate). N1: Regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Seminal Vesicle Leiomyoma

description: A leiomyoma that arises from the seminal vesicle.


name: EBV-Positive Inflammatory Follicular Dendritic Cell/Fibroblastic Reticular Cell Tumor

description: A rare, Epstein-Barr virus-associated variant of follicular dendritic cell sarcoma. It usually arises from the liver or spleen and has a favorable prognosis. The name of this entity has been changed from "sarcoma" to "tumor" because of its indolent nature.


name: Childhood Undifferentiated Pleomorphic Sarcoma

description: An undifferentiated pleomorphic sarcoma that occurs during childhood.


name: Stage IVB Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


name: Superficial Atypical Lipomatous Tumor/Well Differentiated Liposarcoma

description: An atypical lipomatous tumor/well differentiated liposarcoma that occurs in a superficial body structure.


Solitary Adult Fibroma

description: A solitary benign neoplasm arising from the fibrous soft tissues. The tumor is characterized by the presence of spindle-shaped fibroblasts.


name: Vaginal Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle neoplasm that arises from the vagina and cannot be reliably diagnosed as benign or malignant because of the presence of ambiguous morphologic findings.


Gastric Gastrointestinal Stromal Tumor

description: A gastrointestinal stromal tumor that arises from the stomach.  It covers a spectrum of benign to malignant soft tissue neoplasms and includes most gastric smooth muscle tumors, leiomyoblastomas, and tumors formerly called gastrointestinal autonomic nerve tumors.


Plexiform fibrohistiocytic tumor

description: An intermediate fibrohistiocytic neoplasm of the skin that usually affects children and young adults. It is a multinodular, poorly circumscribed tumor characterized by the presence of multinucleated giant cells, mononuclear histiocyte-like cells, and spindle fibroblast-like cells arranged in a plexiform pattern.


Subcutaneous Nodular Fasciitis

description: A self-limiting, rapidly growing, non-encapsulated benign neoplasm arising from the subcutaneous tissues. It is characterized by the growth of plump spindle-shaped fibroblasts in a storiform pattern, multinucleated osteoclast-like giant cells, red blood cell extravasation, chronic inflammatory cells, and high mitotic activity.


name: Uterine Corpus Endometrial Stromal Sarcoma by AJCC v8 Stage

description: A term that refers to the staging of uterine corpus endometrial stroma sarcoma according to the American Joint Committee on Cancer, 8th edition.


name: Superficial CD34-positive fibroblastic tumor

description: A low-grade neoplasm arising from the skin and subcutis. It is characterized by the presence of spindled cells with abundant, eosinophilic, granular to glassy cytoplasm, low mitotic activity, marked nuclear pleomorphism, diffuse CD34 expression, and frequent keratin immunoreactivity. The prognosis is excellent.


Skin Spindle Cell Lipoma

description: A spindle cell lipoma arising from the skin.


Cervical Soft Tissue Neoplasm

description: A benign or malignant mesenchymal neoplasm of the cervix.  Representative examples include rhabdomyoma, alveolar soft part sarcoma, and AIDS-related Kaposi sarcoma.


Synovial sarcoma recurrent

description: The reemergence of synovial sarcoma after a period of remission


name: Extragastrointestinal Gastrointestinal Stromal Tumor

description: A rare gastrointestinal stromal tumor that presents as a solitary mass outside the gastrointestinal tract.


Head and Neck Nodular Fasciitis

description: Nodular fasciitis that arises from the head and neck. It usually affects the face, oral cavity, orbit, ear, parotid gland, and neck.


Stage IIB Soft Tissue Sarcoma AJCC v7

description: Stage IIB includes: (T2a, N0, M0, G2); (T2b, N0, M0, G2).  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G2: Grade 2.  (AJCC 7th ed.)


Cervical Angiosarcoma

description: A highly aggressive malignant vascular neoplasm that arises from the cervix and shows endothelial cell differentiation.


Lipoma of appendix

description: A benign adipose tissue neoplasm involving the wall of the appendix.


name: Sinonasal Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that arises from the nasal cavity and paranasal sinuses.


Parotid Gland Hemangioma

description: A hemangioma arising from the parotid gland.


Omentum Gastrointestinal Stromal Tumor

description: A gastrointestinal stromal tumor that arises from the omentum. This is an extragastrointestinal tumor, meaning that it does not arise directly from the gastrointestinal tract.


name: Dermatofibrosarcoma Protuberans with Giant Cell Fibroblastoma-Like Differentiation

description: A morphologic variant of dermatofibrosarcoma protuberans characterized by areas of fibroblastoma like-differentiation, and the presence of giant cells.


Vulvar Fibrolipoma

description: A lipoma of the vulva with a predominant fibrous component.


Skin Angiolipoma

description: An angiolipoma arising from the skin.


name: Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8

description: Stage IV includes: (Any T, N1, M0, Any G); (Any T, Any N, M1, Any G). N1: Regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Uterine Corpus Sarcoma by AJCC v7 Stage

description: A term that refers to the staging of uterine corpus sarcoma, following the rules of the TNM AJCC v7 classification system.


Parotid Gland Sarcoma

description: A sarcoma that arises from the parotid gland.


name: Recurrent Soft Tissue Sarcoma of the Trunk and Extremities

description: The reemergence of a soft tissue sarcoma of the trunk and extremities after a period of remission.


Gastric Plexiform Fibromyxoma

description: A rare soft tissue neoplasm arising from the stomach.  It occurs in the antrum and pyloric region and it may extend into the duodenum.  It occurs in all ages and affects men and women equally.  Morphologically it is characterized by a multinodular plexiform mass that involves the muscular layer.  The neoplastic cells are spindle-shaped and the mitotic activity is low.  It follows a benign clinical course.


Sinonasal Angiosarcoma

description: An angiosarcoma that arises from the nasal cavity and paranasal sinuses.


Breast Vascular Neoplasm

description: A benign or malignant vascular neoplasm that arises from the breast.