plasmablastic lymphoma

description: An aggressive diffuse large B-cell lymphoma frequently arising in the setting of HIV infection and characterized by the presence of large neoplastic cells resembling B-immunoblasts which have the immunophenotypic profile of plasma cells. Sites of involvement include the oral cavity, sinonasal cavity, skin, soft tissues, gastrointestinal tract, and bone.


Stage IV Adult Burkitt Lymphoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Recurrent Adult Non-Hodgkin Lymphoma

description: The reemergence of non-Hodgkin lymphoma in adults after a period of remission.


B-cell non-Hodgkin lymphoma

description: The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003


splenic marginal zone lymphoma

description: Splenic marginal zone lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma characterized by abnormal clonal proliferation of mature B-lymphocytes with involvement in the spleen, bone marrow and, frequently, the blood. It usually presents with splenomegaly, lymphocytosis, anemia and/or thrombocytopenia. Hepatitis C virus and autoimmune manifestations, such as autoimmune hemolytic anemia and autoimmune thrombocytopenia, could be associated.


Adult T Lymphoblastic Lymphoma

description: T-lymphoblastic lymphoma occurring in adults.


description: The reemergence of Waldenstrom macroglobulinemia after a period of remission.


description: T-cell/histiocyte rich large B cell lymphoma (THRLBCL) is a rare variant of diffuse large B-cell lymphoma (DLBCL), mainly affecting middle-aged men and often not being discovered until an advanced disease stage, with involvement of the spleen, liver and bone marrow occurring at a greater frequency than in DLBCL. It is often difficult to diagnose due to its similarity with other lymphoid diseases such as classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma and has an aggressive clinical course.


name: Ann Arbor Stage I Nodular Lymphocyte Predominant B-Cell Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


name: Ann Arbor Stage IIX (Bulky) Non-Hodgkin Lymphoma

description: Ann Arbor Stage II non-Hodgkin lymphoma with a mass of nodes with one diameter more than 10cm or a mediastinal mass larger than one third of the transthoracic width. (Cotswolds modification)


large-cell immunoblastic lymphoma

description: Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.


name: Refractory Aggressive T-Cell Non-Hodgkin Lymphoma

description: An aggressive T-cell non-Hodgkin lymphoma that is resistant to treatment.


name: Adult T-cell lymphoma/leukemia stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Recurrent Childhood Lymphoblastic Lymphoma

description: The reemergence of lymphoblastic lymphoma in childhood after a period of remission.


name: Burkitt-Like Lymphoma Post-Transplant Lymphoproliferative Disorder

description: A Burkitt-like lymphoma that arises in a patient with a history of organ transplantation.


name: Refractory Follicular Helper T-Cell Lymphoma

description: Follicular helper T-cell lymphoma that is resistant to treatment.


name: high-grade B-cell lymphoma double-hit/triple-hit

description: A B-cell lymphoma that is characterized by the abnormal rearrangement of two genes, MYC gene and either BCL2 or BCL6 genes.


Stage I Adult Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Splenic T Lymphoblastic Lymphoma

description: T-lymphoblastic lymphoma that affects the spleen.


name: Mycosis fungoides/Sezary syndrome stage II

description: Stage II includes: IIA (T1-2, N1-2, M0, B0-1); IIB (T3, N0-2, M0, B0-1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


name: Angioimmunoblastic T-cell lymphoma stage III


Small Intestinal Follicular Lymphoma

description: A follicular lymphoma that arises from the small intestine.  It most often affects the duodenum.


name: Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood non-Hodgkin lymphoma according to the Toronto childhood cancer staging guidelines v2.


name: Nodular Lymphocyte Predominant B-Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for nodular lymphocyte predominant B-cell lymphoma based on the Ann Arbor classification criteria.


Breast T-Cell Non-Hodgkin Lymphoma

description: A T-cell non-Hodgkin lymphoma that arises from the breast as a primary tumor.  Primary T-cell non-Hodgkin lymphomas of the breast are rare.


Stage IB Mycosis Fungoides AJCC v7

description: Stage IB includes: T2, N0, M0, B0-1. T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Head and Neck Mantle Cell Lymphoma

description: A mantle cell lymphoma that affects the head and neck region. The most common site of involvement is the Waldeyer ring, usually the tonsils. Other sites of involvement include the orbit, salivary glands, and nasopharynx.


Acute Adult T-Cell Leukemia/Lymphoma

description: The most common variant of adult T-cell leukemia/lymphoma.  It is characterized by systemic disease with a leukemic phase, generalized lymphadenopathy, and skin lesions.  Hypercalcemia is commonly seen.


name: Ann Arbor Stage II Adult Contiguous Immunoblastic Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type

description: Diffuse large B-cell lymphoma activated B-cell type that is resistant to treatment.


Angiocentric lymphoma stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Recurrent Gray-Zone Lymphoma

description: The reemergence of gray-zone lymphoma after a period of remission.


name: Recurrent Diffuse Large B-Cell Lymphoma Activated B-Cell Type

description: The reemergence of diffuse large B-cell lymphoma activated B-cell type after a period of remission.


name: adult nodular lymphocyte predominant Hodgkin lymphoma

description: A nodular lymphocyte predominant Hodgkin lymphoma occurring in adults.


name: Lacrimal Drainage System Mucosa-Associated Lymphoid Tissue Lymphoma

description: A mucosa-associated lymphoid tissue lymphoma that arises from the lacrimal sac.


Non-Hodgkin Breast Lymphoma

description: A non-Hodgkin lymphoma that arises from the breast.  There is no history of extramammary breast non-Hodgkin lymphoma and ipsilateral axillary lymph node involvement does not exclude the diagnosis of primary breast non-Hodgkin lymphoma.  Most patients present with a painless breast lump.  The vast majority of cases are B-cell non-Hodgkin lymphomas.  Diffuse large B-cell lymphoma, follicular lymphoma, and extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue are the most common types of primary non-Hodgkin lymphoma of the breast.


name: Common Variant Anaplastic Large Cell Lymphoma

description: An anaplastic large cell lymphoma, characterized by CD30 positive lymphoid cells.


Parotid Gland Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the parotid gland.  Representative examples include mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma.


description: Waldenstrom macroglobulinemia with serum IgM monoclonal protein equal or more than 3 g/dL and/or at least 10% bone marrow lymphoplasmacytic infiltration but no evidence of constitutional symptoms, symptomatic anemia, or hyperviscosity. (Blood 2008, 112:2709)


lymphoblastic lymphoma

description: A lymphoma composed of immature small to medium-sized precursor lymphoid cells (lymphoblasts). It includes the B- and T-cell lymphoblastic lymphoma.


name: Adult EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: An EBV-positive diffuse large B-cell lymphoma, not otherwise specified, that occurs in adults. It was originally described in patients older than 50 years, but it has been increasingly recognized in younger patients.


High grade B-cell lymphoma recurrent

description: The reemergence of high-grade B-cell lymphoma after a period of remission.


BN2 diffuse large B-cell lymphoma

description: A diffuse large B-cell lymphoma that is categorized as BN2 with high probability by the LymphGen algorithm. This is based on a combination of genetic features and BN2 DLBCLs often, but do not always, have a translocation involving the BCL6 locus and/or some combination of mutations affecting NOTCH2, TNFAIP3, BCL10 and UBE2A. This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting CD70, which can be coding or non-coding.


Follicular Lymphoma by Ann Arbor Stage

description: An anatomic stage for follicular lymphoma based on the Ann Arbor classification criteria.


Stage III Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Extranodal marginal zone B-cell lymphoma (MALT type) stage II

description: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage II disease.


name: Extranodal marginal zone B-cell lymphoma (MALT type) refractory

description: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that is resistant to treatment.


EBV-Related Burkitt Lymphoma

description: Burkitt lymphoma that is caused by Epstein-Barr virus infection.


name: Refractory Transformed Non-Hodgkin Lymphoma

description: An indolent non-Hodgkin lymphoma which has undergone histologic transformation to an aggressive non-Hodgkin lymphoma and has become resistant to treatment.


Follicular lymphoma stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Diffuse Large B-Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for diffuse large B-cell lymphoma based on the Ann Arbor classification criteria.


name: Stage I Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of a single tumor mass or nodal area, excluding the abdomen and mediastinum. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Ann Arbor Stage I Supradiaphragmatic Nodular Lymphocyte Predominant B-Cell Lymphoma


name: Burkitt Lymphoma Post-Transplant Lymphoproliferative Disorder

description: A Burkitt lymphoma that arises in a patient with a history of organ transplantation.


name: Angioimmunoblastic T-cell lymphoma stage II


folliculotropic mycosis fungoides

description: Folliculotropic mycosis fungoides is a rare variant of mycosis fungoides (MF), a form of cutaneous T-cell lymphoma, and is characterized by the presence of folliculotropic infiltrates in patch-plaque lesions usually involving the head and neck area.


Refractory Plasmablastic Lymphoma

description: Plasmablastic lymphoma that is resistant to treatment.


name: Recurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma

description: The reemergence of transformed follicular lymphoma to diffuse large B-cell lymphoma after a period of remission.


Nasopharyngeal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the nasopharynx.


name: Ann Arbor Stage II Contiguous Adult Aggressive Non-Hodgkin Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: AIDS-Related Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

description: A diffuse large B-cell lymphoma that arises from the central nervous system in AIDS patients.


description: ALK-negative anaplastic large cell lymphoma (ALK- ALCL) is a type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the lack of expression of a protein called anaplastic lymphoma kinase (ALK).


name: Mature T- and NK-Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for mature T- and NK-cell non-Hodgkin lymphomas based on the Ann Arbor classification criteria.


Mantle Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for mantle cell lymphoma based on the Ann Arbor classification criteria.


name: Angioimmunoblastic T-cell lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Primary Uveal Non-Hodgkin Lymphoma

description: An indolent, low-grade B-cell non-Hodgkin lymphoma that arises from the choroid, iris, or ciliary body. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Lymphoid follicles with germinal centers may be present. In the past these tumors were termed 'reactive lymphoid hyperplasia'. Now they are considered low-grade B-cell lymphomas, most commonly extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.


name: Stage III Indolent Adult Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Centroblastic lymphoma recurrent

description: The reemergence of centroblastic lymphoma after a period of remission.


name: Recurrent Primary Cutaneous Diffuse Large B-Cell Lymphoma

description: The reemergence of primary cutaneous diffuse large B-cell lymphoma after a period of remission.


name: Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IB includes: T2, N0, M0, B0,1. T2: Patches, papules, or plaques covering 10% or more of the skin surface. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


name: Ann Arbor Stage IV Mature T- and NK-Cell Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Mycosis fungoides refractory

description: Mycosis fungoides resistant to treatment.


name: Stage IIB Mycosis Fungoides and Sezary Syndrome AJCC v7

description: Stage IIB includes: T3, N0-2, M0, B0-1.  T3: One or more tumors (equal or greater than 1 cm diameter).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


name: Systemic Anaplastic Large Cell Lymphoma, ALK-Positive

description: A T-cell peripheral lymphoma affecting multiple anatomic sites. It is composed of usually large, pleomorphic, CD30 positive T-lymphocytes with abundant cytoplasm. It is characterized by the presence of a translocation involving the ALK gene and expression of ALK fusion protein.


Follicular Helper T-Cell Lymphoma

description: A group of node-based peripheral T-cell lymphomas with phenotypic features of T follicular helper (TFH) cells. This category includes the following: follicular helper T-cell lymphoma, angioimmunoblastic-type; follicular helper T-cell lymphoma, follicular-type; and follicular helper T-cell lymphoma, not otherwise specified.


name: Recurrent Follicular Helper T-Cell Lymphoma

description: The reemergence of follicular helper T-cell lymphoma after a period of remission.


splenic mantle cell lymphoma

description: A mantle cell lymphoma occurring in the spleen.


name: Recurrent Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma

description: The reemergence of diffuse large B-cell lymphoma that resulted from the transformation of marginal zone lymphoma, after a period of remission.


Recurrent Burkitt Lymphoma

description: The reemergence of Burkitt lymphoma after a period of remission.


Prostate Diffuse Large B-Cell Lymphoma

description: A rare diffuse large B-cell lymphoma that arises from the prostate gland.


name: Monomorphic epitheliotropic intestinal T-cell lymphoma

description: A mature T-cell and NK-cell non-Hodgkin lymphoma of intraepithelial T-lymphocytes. It usually arises from the small intestine. A minority of cases arise from the large intestine or the stomach. It is characterized by the presence of a monomorphic cellular infiltrate of small to medium-sized T-lymphocytes that are cytotoxic and express CD56. It is not associated with celiac disease.


name: large B-cell diffuse lymphoma of salivary gland

description: A diffuse large B-cell lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland.


name: Ann Arbor Stage II Grade 1 Follicular Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Childhood Anaplastic Large Cell Lymphoma

description: An anaplastic large cell lymphoma that occurs during childhood.


name: Anaplastic Lymphoma Post-Transplant Lymphoproliferative Disorder

description: An anaplastic lymphoma that arises in a patient with a history of organ transplantation.


name: Stage IV Indolent Adult Non-Hodgkin Lymphoma


enteropathy-associated T-cell lymphoma

description: An uncommon mature T-cell lymphoma of intraepithelial lymphocytes. It usually arises from the small intestine, most commonly the jejunum or ileum. Other less frequent primary anatomic sites include the duodenum, stomach, colon, or outside the gastrointestinal tract. It is seen with increased frequency in regions with a high prevalence of celiac disease.


name: Ann Arbor Stage III Grade 3 Follicular Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


T-cell lymphoma stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


name: Refractory Primary Cutaneous Anaplastic Large Cell Lymphoma

description: Primary cutaneous anaplastic large cell lymphoma that is resistant to treatment.


Sezary syndrome refractory

description: Sezary syndrome that is resistant to treatment.


follicular lymphoma of spleen

description: A follicular lymphoma occurring in the spleen.


name: Refractory Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma

description: Transformed follicular lymphoma to diffuse large B-cell lymphoma that is resistant to treatment.


name: central nervous system anaplastic large cell lymphoma

description: An anaplastic large cell lymphoma that affects the brain, meninges, or spinal cord.


name: Ann Arbor Stage II Grade 1 Contiguous Follicular Lymphoma


name: Lacrimal Gland Mucosa-Associated Lymphoid Tissue Lymphoma

description: A mucosa-associated lymphoid tissue lymphoma that arises from the lacrimal gland.


name: Hodgkin-Like Adult T-Cell Leukemia/Lymphoma

description: A rare morphologic variant of adult T-cell leukemia/lymphoma characterized by the presence of Hodgkin-like and Reed-Sternberg-like cells.


name: Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type by Ann Arbor Stage

description: An anatomic stage for follicular helper T-cell lymphoma, angioimmunoblastic-type  based on the Ann Arbor classification criteria.


Triple hit lymphoma

description: High-grade B-cell lymphoma characterized by the abnormal rearrangement of MYC gene, BCL2 gene, and BCL6 gene. Patients with this type of lymphoma usually respond poorly to standard treatments and have a poor prognosis.


description: Waldenstrom macroglobulinemia that does not respond to treatment.


name: Ann Arbor Stage III Aggressive Adult Non-Hodgkin Lymphoma


Blastoid Variant Mantle Cell Lymphoma

description: An aggressive mantle cell lymphoma characterized by the presence of neoplastic B-lymphocytes resembling lymphoblasts.


name: thyroid gland diffuse large B-cell lymphoma

description: A diffuse large B-cell lymphoma primarily involving the thyroid gland.


name: Ann Arbor Stage I Grade 2 Follicular Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Precursor B-lymphoblastic lymphoma stage III


name: BCL2-R-Negative, CD23-Positive Follicle Center Lymphoma

description: Follicular lymphoma characterized by the absence of BCL2 rearrangement and the presence of CD23-positive neoplastic cells. It is associated with STAT6 mutations. It presents with low-stage disease, typically in the inguinal region, and often has a predominant diffuse growth pattern.


name: Ann Arbor Stage II Grade 2 Contiguous Follicular Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


localized pagetoid reticulosis

description: A variant of mycosis fungoides, characterized by an exclusively intraepidermal atypical (cerebriform) lymphocytic infiltrate. Patients present with a localized psoriasiform or hyperkeratotic patch or plaque, usually in the extremities. Extracutaneous dissemination of the disease has never been reported.


nodal marginal zone B-cell lymphoma

description: Nodal marginal zone B-cell lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma, characterized by abnormal clonal proliferation of mature B-lymphocytes with involvement of the lymph nodes, sometimes the bone marrow, and rarely the blood. Clinically it presents with disseminated peripheral, abdominal and/or thoracic lymphadenopathy. Cytopenia and bulky tumors (greater than 5 cm) are rare. Association with Hepatitis C virus and chronic inflammation has been reported.


name: Refractory Systemic Anaplastic Large Cell Lymphoma

description: Systemic anaplastic large cell lymphoma that does not respond to treatment.


name: Primary Vitreoretinal Non-Hodgkin Lymphoma

description: An uncommon and potentially fatal intraocular non-Hodgkin lymphoma that involves the uvea, retina, vitreous body, and optic nerve. It is a subset of primary central nervous system non-Hodgkin lymphoma. The majority of cases are diffuse large B-cell lymphomas.


grade 3B follicular lymphoma

description: A grade 3 follicular lymphoma composed of solid sheets of centroblasts.


Recurrent Hepatosplenic T-Cell Lymphoma

description: The reemergence of hepatosplenic T-cell lymphoma after a period of remission.


Grade III Lymphomatoid Granulomatosis

description: Lymphomatoid granulomatosis characterized by the presence of aggregates of neoplastic large B-lymphocytes, usually admixed with pleomorphic and Hodgkin-like cells, in a background of chronic inflammation.  Necrotic changes are present and are usually extensive.  Grade III lymphomatoid granulomatosis should be approached clinically as a subtype of diffuse large B-cell lymphoma.


name: Adult Systemic Anaplastic Large Cell Lymphoma

description: An anaplastic large cell lymphoma affecting multiple anatomic sites and occurring in adults.


name: Predominantly Diffuse Follicular Lymphoma with 1p36 Deletion

description: A predominantly diffuse, low-grade follicular lymphoma. It often presents as a large localized inguinal mass, lacks BCL2 rearrangement, and is associated with 1p36 deletion.


Colon Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises from the colon.  It is the most frequent type of lymphoma found in the colon.


Mycosis fungoides stage I

description: Stage I includes: IA (T1, N0, M0, B0-1); IB (T2, N0, M0, B0-1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


name: Stage III Childhood Anaplastic Large Cell Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Nodal marginal zone B-cell lymphoma stage II


Childhood Immunoblastic Lymphoma

description: An immunoblastic lymphoma (a variant of diffuse large B-cell lymphoma) occurring in children.


Prostate Mantle Cell Lymphoma

description: A rare mantle cell lymphoma that arises from the prostate gland.


description: The reemergence of lymphoplasmacytic lymphoma after a period of remission.


name: Refractory Transformed T-cell Non-Hodgkin Lymphoma

description: An indolent T-cell non-Hodgkin lymphoma which has undergone histologic transformation to an aggressive T-cell non-Hodgkin lymphoma and has become resistant to treatment.


Non-Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for non-Hodgkin lymphomas based on the Ann Arbor classification criteria.


name: Stage IVB Mycosis Fungoides and Sezary Syndrome AJCC v7

description: Stage IVB includes: T1-4, N0-3, M1, B0-2. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative.  M1: Visceral involvement (must have pathology confirmation and organ involved should be specified).  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone.  (AJCC 7th ed.)


name: Lymphoplasmacytoid lymphoma/immunocytoma stage III


name: Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

description: Mature T-cell and NK-cell non-Hodgkin lymphoma that is resistant to treatment.


name: AIDS-Related Non-Hodgkin Lymphoma of the Cervix

description: A non-Hodgkin lymphoma that arises from the cervix in a patient with acquired immunodeficiency syndrome.


name: Liver Mucosa-Associated Lymphoid Tissue Lymphoma

description: A rare mucosa-associated lymphoid tissue lymphoma that arises from the liver.  It is characterized by the presence of centrocyte-like cells surrounding germinal centers.  Lymphoepithelial lesions involving the bile duct epithelium may also be present.


Cyclin D1-Positive Mantle Cell Lymphoma

description: A molecular subtype of mantle cell lymphoma characterized by the presence of cyclin D1 expression and/or CCND1 rearrangement..


Mature B-Cell Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that originates from mature B lymphocytes. Representative examples include diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, mantle cell lymphoma, and small lymphocytic lymphoma.


name: small cell variant anaplastic large cell lymphoma

description: A histologic variant of anaplastic large cell lymphoma characterized by the presence of a predominant population of small to medium size malignant cells with irregular nuclei.


name: Ann Arbor Stage II Non-Contiguous Mantle Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Ann Arbor Stage I Aggressive Adult Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Refractory Gray-Zone Lymphoma

description: Gray-zone lymphoma that is resistant to treatment.


name: Anaplastic large cell lymphoma T- and null-cell types refractory

description: Anaplastic large cell lymphoma resistant to treatment.


Mediastinal Non-Hodgkin Lymphoma

description: Non-Hodgkin lymphoma arising from the mediastinum.


name: Chlamydia Psittaci-Associated Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma

description: Mucosa-associated lymphoid tissue lymphoma that arises from the ocular adnexa and caused by stimulation of lymphoid tissue due to Chlamydia psittaci bacterial infection.


Colorectal Burkitt Lymphoma

description: A rare Burkitt lymphoma that arises from the colon or rectum.


name: Recurrent Systemic Anaplastic Large Cell Lymphoma

description: The reemergence of systemic anaplastic large cell lymphoma after a period of remission.


Stage IV Diffuse Large B-Cell Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Colon Mantle Cell Lymphoma

description: A mantle cell lymphoma that arises from the colon.  It often presents as a polypoid lesion.


name: Smoldering Adult T-Cell Leukemia/Lymphoma

description: An adult T-cell leukemia/lymphoma characterized by less than 5% neoplastic lymphocytes in the peripheral blood, absence of lymphadenopathy and hypercalcemia, and occasional skin or pulmonary lesions.


follicular malignant lymphoma of breast

description: A follicular lymphoma that arises from the breast as a primary tumor.


name: Charcot-Marie-Tooth disease X-linked recessive 3

description: X-linked Charcot-Marie-Tooth disease type 3 is a rare, genetic, peripheral sensorimotor neuropathy characterized by an X-linked recessive inheritance pattern and the childhood- to adolescent-onset of progressive, distal muscle weakness and atrophy (beginning in the lower extremities and then affecting the upper extremities), as well as distal, pansensory loss in the upper and lower extremities, pes cavus, and absent or reduced distal tendon reflexes. Pain and paresthesia are frequently the initial sensory symptoms. Spastic paraparesis (manifested by clasp-knife sign, hyperactive deep-tendon reflexes, and Babinski sign) has also been reported.


name: Charcot-Marie-Tooth disease X-linked recessive 2

description: X-linked Charcot-Marie-Tooth disease type 2 is a rare, genetic, peripheral sensorimotor neuropathy characterized by an X-linked recessive inheritance pattern and the infantile- to childhood-onset of progressive, distal muscle weakness and atrophy (more prominent in the lower extremities than in the upper extremities), pes cavus, and absent tendon reflexes. Sensory impairment and intellectual disability has been reported in some individuals.


statin (semi-synthetic)

A statin that is derived from a naturally occurring statin by partial chemical synthesis.


hippocampal sclerosis of aging

description: Age-related neuropathological condition with severe neuronal cell loss and gliosis in the hippocampus


Benign cyst of ovary

description: A non-malignant ovarian cyst.


name: Large Solitary Luteinized Follicle Cyst of Ovary

description: A large, unilateral, solitary ovarian cyst lined by luteinized cells, occurring during pregnancy or puerperium. (WHO 2020)


Complex ovarian cyst

description: A cystic lesion that arises from the ovary. It is characterized by the presence of cystic spaces that contain fluid and a solid tissue component.


Unilocular Ovarian Cyst

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: An ovarian cyst that has a single compartment.


Follicular cyst of ovary

description: A benign ovarian cyst that develops from a persistent, unruptured Graafian follicle, which grows larger than three centimeters.


Autonomous Ovarian Follicular Cyst

description: A cyst arising from an ovarian follicle that produces hormones independent of gonadotropin stimulation.


Functional cyst of ovary

description: A benign ovarian cyst that develops and regresses during the menstrual cycle as part of normal ovarian function.


FIGO Stage IIIB Ovarian Cancer

description: Ovarian cancer with macroscopic, extrapelvic, peritoneal metastasis equal or less than 2 cm +/- positive retroperitoneal lymph nodes. Includes extension to capsule of liver/spleen. (FIGO, 2014)


nocardiosis

description: Nocardiosis is a local (skin, lung, brain) or disseminated (whole body) acute, subacute, or chronic bacterial infection.


name: Recurrent T Acute Lymphoblastic Leukemia

description: The reemergence of T-acute lymphoblastic leukemia after a period of remission.


name: Recurrent Childhood T Acute Lymphoblastic Leukemia

description: The reemergence of T-acute lymphoblastic leukemia in childhood after a period of remission.


name: FLVCR1-related retinopathy with or without ataxia

description: A disorder characterized by retinopathy with ataxia in most patients, caused by biallelic variants in the FLVCR1 gene.


Mononegavirales infectious disease

description: Infections with viruses of the order mononegavirales. The concept includes filoviridae infections; paramyxoviridae infections; and rhabdoviridae infections.


name: parainfluenza virus type 2 infectious disease

description: A disease caused by infection with parainfluenza virus type 2.


name: fetal parainfluenza virus type 3 syndrome

description: A syndrome caused by HPIV-3.


name: parainfluenza virus type 3 infectious disease

description: Parainfluenza virus type 3 is one of a group of common viruses known as human parainfluenza viruses (HPIV) that cause a variety of respiratory illnesses. Symptoms usually develop between 2 and 7 days from the time of exposure and typically resolve in 7-10 days. Symptoms may include fever, runny nose, and cough. HPIV-3 can also cause bronchiolitis, bronchitis, and pneumonia. Infants and young children are particularly susceptible to HPIV-3 infections, though older adults and those with a weakened immune system are also at risk for complications. HPIVs are usually spread from an infected person to others through coughing, sneezing, and/or touching. There is currently no vaccine to protect against parainfluenza virus infections. Most HPIV infections resolve on their own and do not require special treatment, though medical intervention may be necessary for severe breathing problems. Most adults have antibodies against parainfluenza but can get repeat infections.


henipavirus infectious disease

description: Infections with viruses of the genus henipavirus, family paramyxoviridae.


Rhabdoviridae infectious disease

description: Virus diseases caused by rhabdoviridae. Important infections include rabies; ephemeral fever; and vesicular stomatitis.


Marburg hemorrhagic fever

description: Marburg hemorrhagic fever (MHF), caused by Marburg virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure.


borna virus encephalitis

description: A human disease caused by infection with Borna disease virus.


morbillivirus infectious disease

description: Infections with viruses of the genus morbillivirus, family paramyxoviridae. Infections mainly cause acute disease in their hosts, although in some cases infection is persistent and leads to degenerative conditions.


respirovirus infectious disease

description: Infections with viruses of the genus respirovirus, family paramyxoviridae. Host cell infection occurs by adsorption, via hemagglutinin, to the cell surface.


Paramyxoviridae infectious disease

description: Infections with viruses of the family paramyxoviridae. This includes morbillivirus infections; respirovirus infections; pneumovirus infections; henipavirus infections; avulavirus infections; and rubulavirus infections.


Filoviridae infectious disease

description: Infections with viruses of the family filoviridae. The infections in humans consist of a variety of clinically similar viral hemorrhagic fevers but the natural reservoir host is unknown.


name: parainfluenza virus type 4 infectious disease

description: A disease caused by infection with parainfluenza virus type 4.


Nipah virus disease

description: Nipah virus disease, caused by the Nipah virus, is a recently discovered zoonotic disease characterized by fever, constitutional symptoms and encephalitis, sometimes accompanied by respiratory illness.


name: parainfluenza virus type 1 infectious disease

description: A disease caused by infection with parainfluenza virus type 1.


parainfluenza infectious disease

description: A disease caused by infection with parainfluenza virus. There are four serotypes which cause respiratory illnesses in children and adults.


Avulavirus infectious disease

description: Infections with viruses of the genus avulavirus, family paramyxoviridae. This includes newcastle disease and other infections of domestic fowl.


name: adult central nervous system choriocarcinoma

description: A choriocarcinoma of the central nervous system that occurs in an adult.


Ciliary Body Adenoma

description: A benign neoplasm of the pigmented ciliary epithelium (pigmented epithelial adenoma) and/ or the non-pigmented ciliary epithelium (non-pigmented epithelial adenoma). (WHO 2018)


Smouldering systemic mastocytosis

description: Smouldering systemic mastocytosis is a type of systemic mastocytosis (SM). This clonal hematologic disease, with a slow progression, results in an accumulation of neoplastic mast cells in the visceral organs over time and patients present with splenomegaly, hypercellular marrow and, in some cases, urticaria pigmentosa-like skin lesions.


L-histidine derivative

A proteinogenic amino acid derivative resulting from the formal reaction of L-histidine at the amino group, carboxy group, or the imidazolyl moiety, or from the replacement of any hydrogen of L-histidine by a heteroatom.


name: diastasis recti and weakness of the linea alba


name: Inflammatory Malignant Fibrous Histiocytoma NCI Grade 2


dipsogenic diabetes insipidus

description: Diabetes insipidus caused by excessive intake of water due to psychological factors or damage to the thirst-regulating mechanism.


adult papillary meningioma

description: A papillary meningioma occurring in adults.


cyclitol

A polyol consisting of a cycloalkane containing at least three hydroxy groups, each attached to a different ring carbon atom.


amino cyclitol

Any cyclitol having one or more alcoholic hydroxy groups replaced by substituted or unsubstituted amino groups.


myo-inositol phosphate

An inositol phosphate in which the inositol component has myo-configuration.


name: B Acute Lymphoblastic Leukemia with Intrachromosomal Amplification of Chromosome 21

description: B-acute lymphoblastic leukemia characterized by amplification of a portion of chromosome 21. It usually occurs in children and is associated with an adverse prognosis.


name: Testicular Mixed Germ Cell-Sex Cord-Stromal Tumor

description: A testicular mixed germ cell-sex cord-stromal tumor in which the neoplastic germ cells and the neoplastic sex cord-stromal cells do not form nests and are instead arranged in a diffuse pattern.


Empyema with fistula

description: An empyema with a fistula.


name: Advanced Chromophobe Renal Cell Carcinoma

description: Chromophobe renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Adenocarcinoma

description: An adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Progesterone Receptor-Positive Breast Carcinoma

description: Progesterone receptor-positive breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Ovarian Clear Cell Adenocarcinoma

description: Ovarian clear cell adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


description: Intrahepatic cholangiocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Sebaceous Carcinoma

description: Sebaceous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Distal Bile Duct Adenocarcinoma

description: Distal bile duct adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced renal cell carcinoma

description: Renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Prostate Adenocarcinoma with Neuroendocrine Differentiation

description: Prostate adenocarcinoma with neuroendocrine differentiation that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Gastric Adenocarcinoma

description: Gastric adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Hormone Receptor-Negative Breast Carcinoma

description: Hormone receptor-negative breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Unclassified Renal Cell Carcinoma

description: A renal cell carcinoma, not otherwise specified, that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Triple-Negative Breast Carcinoma

description: Triple-negative breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Cervical Adenocarcinoma

description: A cervical adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Hepatocellular Carcinoma

description: Hepatocellular carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Cholangiocarcinoma

description: A cholangiocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Estrogen Receptor-Positive Breast Carcinoma

description: Estrogen receptor-positive breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Endometrial Adenocarcinoma

description: Endometrial adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Primary Peritoneal High Grade Serous Adenocarcinoma

description: A primary peritoneal high-grade serous adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Breast Adenocarcinoma

description: Breast adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Appendix Adenocarcinoma

description: Appendix adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Sarcomatoid Renal Cell Carcinoma

description: Sarcomatoid renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Hilar Cholangiocarcinoma

description: Hilar cholangiocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Fallopian Tube High Grade Serous Adenocarcinoma

description: A fallopian tube high-grade serous adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Adult Hepatocellular Carcinoma

description: A hepatocellular carcinoma that occurs during adulthood and has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Papillary Renal Cell Carcinoma

description: A papillary renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Endometrial Serous Adenocarcinoma

description: Endometrial serous adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Vaginal Adenocarcinoma

description: Vaginal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Gastroesophageal Junction Adenocarcinoma

description: Gastroesophageal junction adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Colorectal Adenocarcinoma

description: Colorectal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Esophageal Adenocarcinoma

description: Esophageal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced HER2-Positive Breast Carcinoma

description: HER2-positive breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Pancreatic Adenocarcinoma

description: Pancreatic adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Adenocarcinoma of Unknown Primary

description: An adenocarcinoma of unknown primary that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Hormone Receptor-Positive Breast Carcinoma

description: Hormone receptor-positive breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Pancreatic Ductal Adenocarcinoma

description: Pancreatic ductal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Rectal Adenocarcinoma

description: Rectal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Lung Adenocarcinoma

description: Lung adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Colon Adenocarcinoma

description: Colon adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Adrenal Cortical Carcinoma

description: Adrenal cortical carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Fibrolamellar Carcinoma

description: Fibrolamellar carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma that has spread extensively from the original site of growth to other anatomic sites or is no longer responding to treatment.


Advanced HER2-Negative Breast Carcinoma

description: A HER2-negative breast adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Prostate Adenocarcinoma

description: A prostatic adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Ovarian Endometrioid Adenocarcinoma

description: Ovarian endometrioid adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Locally Advanced Unresectable Gallbladder Carcinoma

description: Gallbladder carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Stage IIIA Uveal Melanoma AJCC v7

description: Stage IIIA includes: (T2c-d, N0, M0); (T3b-c, N0, M0); (T4a, N0, M0).  T2c: Ciliary body and choroid: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T2d: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T3b: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement. T3c: Ciliary body and choroid: Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T4a: Iris: Tumor with extrascleral extension less than or equal to 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 without ciliary body involvement and extraocular extension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Achard syndrome

description: A rare genetic syndrome featuring connective tissue abnormalities. Clinical signs include brachycephaly, arachnodactyly, receding mandible and joint laxity at the hands and feet.


acne keloid

description: A chronic eruption of fibrous papules that develop and fuse to form a thick sclerotic, hypertrophic band at a site of deep folliculitis, usually along the posterior hairline of the scalp. It is most commonly seen in men of African descent.


canine prostate carcinoma

description: A malignant epithelial neoplasm arising from the prostate gland of a dog.


Either of the two diastereoisomers of 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine in which the imidazol-1-ylmethyl group and the aryloxymethyl group are in a cis relationship to each other - i.e. they are both on the same side of the plane of the dioxolane ring. The antifungal drug ketoconazole is a racemic mixture of the two cis diastereoisomers.


Either of the two diastereoisomers of 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine in which the imidazol-1-ylmethyl group and the aryloxymethyl group are in a trans relationship to each other - i.e. they are on opposite sides of the plane of the dioxolane ring. (N.B. The antifungal drug ketoconazole is a racemic mixture of the two cis diastereoisomers.)


terconazole

A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by 2,4-dichlorophenyl, 1H-1,2,4-triazol-1-ylmethyl, and [4-(4-isopropylpiperazin-1-yl)phenoxy]methyl groups, respectively.


Metastatic rectal adenocarcinoma

description: An adenocarcinoma that arises from the rectum and has metastasized to another anatomic site.


name: Locally Advanced Unresectable Rectal Adenocarcinoma

description: A rectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Rectal Adenocarcinoma

description: Rectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


BCOR-CCNB3 sarcoma

description: A sarcoma with BCOR genetic alterations that is characterized by the presence of BCOR-CCNB3 fusion gene.


name: mixed phenotype acute leukemia with BCR-ABL1

description: An acute biphenotypic leukemia that is characterized by blasts that also carry the translocation t(9;22)(q34.1;q11.2) by karyotypic analysis or the BCR-ABL1 translocation by FISH or PCR.


name: Acute Leukemia of Ambiguous Lineage with Defining Genetic Abnormalities

description: Acute leukemia of ambiguous lineage characterized by the presence of defined genetic alterations.


name: mixed phenotype acute leukemia with t(v;11q23.3)

description: A rare mixed phenotype acute leukemia in which the blasts carry a translocation between the KMT2A gene at 11q23.3 and another gene partner. The prognosis is usually unfavorable.


name: Acute Leukemia of Ambiguous Lineage with BCL11B Rearrangement

description: A rare acute leukemia of ambiguous lineage characterized by the presence of BCL11B gene rearrangement.


name: medium chain 3-ketoacyl-Coa thiolase deficiency


name: BRCA1-Associated Hereditary Breast and Ovarian Cancer Syndrome

description: An autosomal dominant inherited syndrome caused by deleterious mutations in the BRCA1 gene. Patients are at high risk of developing breast cancer, ovarian cancer, and other cancers including cervical, endometrial, fallopian tube, and colon cancer.


name: PUM1-associated developmental disability-ataxia-seizure syndrome


name: infantile-onset mesial temporal lobe epilepsy with severe cognitive regression

description: A rare monogenic disease with infantile-onset pharmacoresistant focal seizures of mesial temporal lobe onset manifesting with unresponsiveness, hypertonia and automatisms and cognitive regression soon after seizure onset leading to severe intellectual disability with behavioral abnormalities.


name: focal epilepsy-intellectual disability-cerebro-cerebellar malformation

description: Focal epilepsy-intellectual disability-cerebro-cerebellar malformation is a rare, genetic neurological disorder characterized by early infantile-onset of seizures, borderline to moderate intellectual disability, cerebellar features including dysarthria and ataxia and cerebellar atrophy and cortical thickening observed on MRI imaging. Seizures are typically focal (with prominent eye blinking, facial and limb jerking), precipitated by fever and often commence with an oral sensory aura (anesthetized tongue sensation). When not properly controlled by anti-epileptic medication, weekly frequency and persistence into adult life is observed.


name: Mowat-Wilson syndrome due to a ZEB2 point mutation


name: X-linked dominant intellectual disability-epilepsy syndrome


name: Mowat-Wilson syndrome due to monosomy 2q22


FOXG1 disorder

description: A monogenic disease that has material basis in mutation in the FOXG1 gene.


name: autosomal recessive cerebellar ataxia - epilepsy - intellectual disability syndrome


name: X-linked intellectual disability-epilepsy syndrome


name: epilepsy, X-linked 2, with or without impaired intellectual development and dysmorphic features


name: epilepsy, X-linked, with or without impaired intellectual development and dysmorphic features


name: global developmental delay-neuro-ophthalmological abnormalities-seizures-intellectual disability syndrome


name: FOXG1 syndrome due to intragenic alteration


name: developmental and epileptic encephalopathy, 73


name: Lung Large Cell Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of large cell lung carcinoma, following the rules of the TNM AJCC v7 classification system.


name: Stage IIA Lung Large Cell Carcinoma AJCC v7

description: Stage IIA includes: (T2b, N0, M0); (T1a, N1, M0); (T1b, N1, M0); (T2a, N1, M0).  T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension.  T1a: Lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis. (AJCC 7th ed.)


Large cell lung cancer stage III

description: Stage III includes: IIIA (T1a, N2, M0); (T1b, N2, M0); (T2a, N2, M0); (T2b, N2, M0); (T3, N1, M0); (T3, N2, M0); (T4, N0, M0); (T4, N1, M0) and IIIB (T1a, N3, M0); (T1b, N3, M0); (T2a, N3, M0); (T2b, N3, M0); (T3, N3, M0); (T4, N2, M0); (T4, N3, M0).  T4: Lung cancer with a tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina, and separate tumor nodule(s) in a different ipsilateral lobe.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension.  N2: Lung cancer with metastasis to ipsilateral mediastinal and/or subcarinal lymph nodes.  N3: Lung cancer with metastasis to contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IIIA Lung Large Cell Carcinoma AJCC v7

description: Stage IIIA includes: (T1a, N2, M0); (T1b, N2, M0); (T2a, N2, M0); (T2b, N2, M0); (T3, N1, M0); (T3, N2, M0); (T4, N0, M0); (T4, N1, M0).  T4: Lung cancer with a tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina, and separate tumor nodule(s) in a different ipsilateral lobe.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension.  N2: Lung cancer with metastasis to ipsilateral mediastinal and/or subcarinal lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


Large cell lung cancer stage II

description: Stage II includes: IIA (T2b, N0, M0); (T1a, N1, M0); (T1b, N1, M0); (T2a, N1, M0) and IIB (T2b, N1, M0); (T3, N0, M0).  T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension.  T1a: Lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  T3: Lung cancer with a tumor size more than 7 cm or one that directly invades any of the following: parietal pleural (PL3) chest wall (including superior sulcus tumors), diaphragm, phrenic nerve, mediastinal pleura, parietal pericardium; or tumor in the main bronchus (less than 2 cm distal to the carina but without involvement of the carina); or associated atelectasis or obstructive pneumonitis of the entire lung or separate tumor nodule(s) in the same lobe. N0: No regional lymph node metastasis.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IA Lung Large Cell Carcinoma AJCC v7

description: Stage IA includes: (T1a, N0, M0); (T1b, N0, M0).  T1a: Lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IB Lung Large Cell Carcinoma AJCC v7

description: Stage IB includes: T2a, N0, M0.  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Large cell lung cancer stage I

description: Stage I includes: IA: (T1a, N0, M0); (T1b, N0, M0) and IB: (T2a, N0, M0).  T1a: Lung cancer with a tumor size of 2 cm or less n greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IIB Lung Large Cell Carcinoma AJCC v7

description: Stage IIB includes: (T2b, N1, M0); (T3, N0, M0).  T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension.  T3: Lung cancer with a tumor size more than 7 cm or one that directly invades any of the following: parietal pleural (PL3) chest wall (including superior sulcus tumors), diaphragm, phrenic nerve, mediastinal pleura, parietal pericardium; or tumor in the main bronchus (less than 2 cm distal to the carina but without involvement of the carina); or associated atelectasis or obstructive pneumonitis of the entire lung or separate tumor nodule(s) in the same lobe. N0: No regional lymph node metastasis.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage 0 Lung Large Cell Carcinoma AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Large cell lung cancer stage IV

description: Stage IV includes: (Any T, Any N, M1a); (Any T, Any N, M1b).  M1a: Lung cancer with separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules or malignant pleural (or pericardial) effusion.  M1b: Distant metastasis. (AJCC 7th ed.)


name: Stage IIIB Lung Large Cell Carcinoma AJCC v7

description: Stage IIIB includes: (T1a, N3, M0); (T1b, N3, M0); (T2a, N3, M0); (T2b, N3, M0); (T3, N3, M0); (T4, N2, M0); (T4, N3, M0).  T4: Lung cancer with a tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina, and separate tumor nodule(s) in a different ipsilateral lobe.  N2: Lung cancer with metastasis to ipsilateral mediastinal and/or subcarinal lymph nodes.  N3: Lung cancer with metastasis to contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


name: Untreated Childhood Pilomyxoid Astrocytoma

description: A finding of pilomyxoid astrocytoma in childhood that has not been treated.


name: Cerebellar and Brain Stem Ependymal Tumor

description: A finding indicating the presence of an ependymal tumor in the cerebellum and brain stem.


name: Stage IV AIDS-Related Anal Canal Cancer AJCC v6 and v7

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th and 7th Eds.)


AIDS-Related Anal Canal Carcinoma

description: A carcinoma arising from the anal canal and occurring in HIV-positive patients.


name: Stage III AIDS-Related Anal Canal Cancer AJCC v6 and v7

description: Stage III includes: IIIA (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N0, M0); IIIB (T4, N1, M0); (Any T, N2, M0); (Any T, N3, M0).  T1: Tumor 2 cm or less in greatest dimension.  T2: tumor more than 2 cm but not more than 5 cm in greatest dimension.  T3: Tumor more than 5 cm in greatest dimension.  T4: Tumor of any size that invades adjacent organ(s).  N1: Metastasis in perirectal lymph node(s).  N0: No regional lymph node metastasis.  N2: Metastasis in unilateral internal iliac and/or inguinal lymph node(s).  N3: Metastasis in perirectal and inguinal lymph nodes and/or bilateral internal iliac and/or inguinal lymph nodes. M0: No distant metastasis. (AJCC 6th and 7th Eds.)


AIDS-related anal cancer recurrent

description: The reemergence of anal canal carcinoma in HIV-positive patients after a period of remission.


name: Stage 0 AIDS-Related Anal Canal Cancer AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


name: Stage II AIDS-Related Anal Canal Cancer AJCC v6 and v7

description: Stage II includes: (T2, N0, M0); (T3,N0, M0).  T2: Tumor more than 2 cm but not more than 5 cm in greatest dimension.  T3: Tumor more than 5 cm in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


name: Stage I AIDS-Related Anal Canal Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


Refractory Small Intestinal Carcinoma

description: Small intestinal carcinoma that is resistant to treatment.


Advanced Kidney Carcinoma

description: Kidney carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Renal Pelvis Urothelial Carcinoma

description: Renal pelvis urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Kidney Medullary Carcinoma

description: Kidney medullary carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Renal Pelvis Carcinoma

description: Renal pelvis carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


cerebrospinal fluid leak

description: Discharge of cerebrospinal fluid through a hole through the skull bone most commonly draining from the nose (CEREBROSPINAL FLUID RHINORRHEA) or the ear (CEREBROSPINAL FLUID OTORRHEA).


retinal

An enal that consists of 3,7-dimethyl-9-nona-2,4,6,8-tetraenal (double bond geometry unspecified) carrying a 2,6,6-trimethylcyclohex-1-en-1-yl group at the 9-position.


transient tyrosinemia of the newborn

description: A benign disorder of tyrosine metabolism detected upon newborn screening and often observed in premature infants. It shows no clinical symptoms. It is characterized by tyrosinemia, moderate hyperphenylalaninemia, and tyrosiluria that usually resolve after 2 months of age.


name: Stage IIA Adult Soft Tissue Sarcoma AJCC v7


Stage IIA Soft Tissue Sarcoma AJCC v7

description: Stage IIA includes: (T1a, N0, M0, G2, G3); (T1b, N0, M0, G2, G3).  T1a: Superficial tumor 5 cm or less in greatest dimension.  T1b: Deep tumor 5 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G2: Grade 2.  G3: Grade 3. (AJCC 7th ed.)


infectious mononucleosis

description: A condition characterized by an increase in mononuclear white blood cells and swollen lymph nodes, which is usually caused by infection with the Epstein-Barr virus.


Medulloblastoma, SHH-2

description: Medulloblastoma, SHH-activated, characterized by chromosome 9q loss and nodular morphology. It affects mostly infants.


Sarcoma NCI Grade 3

description: A sarcoma with more than 15% necrosis.


Kaposi Sarcoma NCI Grade 3

description: A Kaposi sarcoma with more than 15% necrosis.


Epithelioid Sarcoma NCI Grade 3

description: An epithelioid sarcoma with more than 15% necrosis.


Angiosarcoma NCI Grade 3

description: An angiosarcoma with more than 15% necrosis.


Leiomyosarcoma NCI Grade 3

description: A leiomyosarcoma with more than 15% necrosis.


name: digestive duplication cyst of the tongue

description: Digestive duplication cyst of the tongue is an extremely rare otorhinolaryngological malformation which occurs during early embryogenesis and is characterized by a single, and on occasion multiple, cystic lesion that is most frequently located in the anterior portion of the tongue, either deeply embedded within it or superficially on it. Depending mostly on size and location of the cyst, patients could be asymptomatic or could present a wide array of symptoms, such as varying degrees of respiratory and feeding difficulties, lingual swelling and protrusion, dysphagia, and more rarely, recurrent bleeding or brownish discharge from a lingual sinus.


Adenosquamous cell lung cancer stage II

description: Stage II includes: IIA (T2b, N0, M0); (T1a, N1, M0); (T1b, N1, M0); (T2a, N1, M0) and IIB (T2b, N1, M0); (T3, N0, M0).  T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension.  T1a: Lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  T3: Lung cancer with a tumor size more than 7 cm or one that directly invades any of the following: parietal pleural (PL3) chest wall (including superior sulcus tumors), diaphragm, phrenic nerve, mediastinal pleura, parietal pericardium; or tumor in the main bronchus (less than 2 cm distal to the carina but without involvement of the carina); or associated atelectasis or obstructive pneumonitis of the entire lung or separate tumor nodule(s) in the same lobe. N0: No regional lymph node metastasis.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis. (AJCC 7th ed.)


name: Lung Adenosquamous Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of adenosquamous lung carcinoma, following the rules of the TNM AJCC v7 classification system.


name: Adenosquamous cell lung cancer stage III

description: Stage III includes: IIIA (T1a, N2, M0); (T1b, N2, M0); (T2a, N2, M0); (T2b, N2, M0); (T3, N1, M0); (T3, N2, M0); (T4, N0, M0); (T4, N1, M0) and IIIB (T1a, N3, M0); (T1b, N3, M0); (T2a, N3, M0); (T2b, N3, M0); (T3, N3, M0); (T4, N2, M0); (T4, N3, M0).  T4: Lung cancer with a tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina, and separate tumor nodule(s) in a different ipsilateral lobe.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension.  N2: Lung cancer with metastasis to ipsilateral mediastinal and/or subcarinal lymph nodes.  N3: Lung cancer with metastasis to contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


Adenosquamous cell lung cancer stage I

description: Stage I includes: IA: (T1a, N0, M0); (T1b, N0, M0) and IB: (T2a, N0, M0).  T1a: Lung cancer with a tumor size of 2 cm or less n greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Adenosquamous cell lung cancer stage IV

description: Stage IV includes: (Any T, Any N, M1a); (Any T, Any N, M1b).  M1a: Lung cancer with separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules or malignant pleural (or pericardial) effusion.  M1b: Distant metastasis. (AJCC 7th ed.)


name: Stage IA Lung Adenosquamous Carcinoma AJCC v7

description: Stage IA includes: (T1a, N0, M0); (T1b, N0, M0).  T1a: Lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Stage 0 Lung Adenosquamous Carcinoma AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage IIB Lung Adenosquamous Carcinoma AJCC v7

description: Stage IIB includes: (T2b, N1, M0); (T3, N0, M0).  T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension.  T3: Lung cancer with a tumor size more than 7 cm or one that directly invades any of the following: parietal pleural (PL3) chest wall (including superior sulcus tumors), diaphragm, phrenic nerve, mediastinal pleura, parietal pericardium; or tumor in the main bronchus (less than 2 cm distal to the carina but without involvement of the carina); or associated atelectasis or obstructive pneumonitis of the entire lung or separate tumor nodule(s) in the same lobe. N0: No regional lymph node metastasis.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IIA Lung Adenosquamous Carcinoma AJCC v7

description: Stage IIA includes: (T2b, N0, M0); (T1a, N1, M0); (T1b, N1, M0); (T2a, N1, M0).  T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension.  T1a: Lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis. (AJCC 7th ed.)


name: Adenosquamous cell lung cancer stage IIIB

description: Stage IIIB includes: (T1a, N3, M0); (T1b, N3, M0); (T2a, N3, M0); (T2b, N3, M0); (T3, N3, M0); (T4, N2, M0); (T4, N3, M0).  T4: Lung cancer with a tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina, and separate tumor nodule(s) in a different ipsilateral lobe.  N2: Lung cancer with metastasis to ipsilateral mediastinal and/or subcarinal lymph nodes.  N3: Lung cancer with metastasis to contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IB Lung Adenosquamous Carcinoma AJCC v7

description: Stage IB includes: T2a, N0, M0.  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Adenosquamous cell lung cancer stage IIIA

description: Stage IIIA includes: (T1a, N2, M0); (T1b, N2, M0); (T2a, N2, M0); (T2b, N2, M0); (T3, N1, M0); (T3, N2, M0); (T4, N0, M0); (T4, N1, M0).  T4: Lung cancer with a tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina, and separate tumor nodule(s) in a different ipsilateral lobe.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension.  N2: Lung cancer with metastasis to ipsilateral mediastinal and/or subcarinal lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


Conjunctival Subepithelial Nevus

description: A conjunctival nevus characterized by an intrastromal proliferation of predominantly type B nevus cells.


RHYNS syndrome

description: RHYNS syndrome is characterized by the association of retinitis pigmentosa, hypopituitarism, nephronophthisis, and skeletal dysplasia.


name: isolated focal cortical dysplasia type Ib


name: isolated focal cortical dysplasia type I


name: isolated focal cortical dysplasia type Ia


name: isolated focal cortical dysplasia type Ic


episodic kinesigenic dyskinesia

description: Paroxysmal kinesigenic dyskinesia (PKD) is a form of paroxysmal dyskinesia, characterized by recurrent brief involuntary hyperkinesias, such as choreoathetosis, ballism, athetosis or dystonia, triggered by sudden movements.


episodic kinesigenic dyskinesia 2

description: A dystonia characterized by autosomal dominant inheritance of recurrent brief involuntary hyperkinesias triggered by sudden movements that has material basis in variation in the chromosome region 16q13-q22.1.


paroxysmal nonkinesigenic dyskinesia 2

description: A dystonia characterized by autosomal dominant inheritance of attacks of dystonic or choreathetotic movements precipitated by stress, fatigue, coffee or alcohol intake or menstruation that has material basis in variation in the chromosome region 2q31.


paroxysmal nonkinesigenic dyskinesia

description: Paroxysmal non-kinesigenic dyskinesia (PNKD) is a form of paroxysmal dyskinesia, characterized by attacks of dystonic or choreathetotic movements precipitated by stress, fatigue, coffee or alcohol intake or menstruation.


ECHS1-related paroxysmal dyskinesia

description: A paroxysmal dyskinesia which manifest as dystonic movements brought on by sustained exercise, that is correlated with a deficiency in the gene ECHS1 (caused by a missence mutation). Onset is typically between age two and four years.


ketoimine

A ketimine, R2C=NR' (R =/= H), in which R' is a keto (C=O) group.


Cervical Rhabdomyoma

description: A rare benign skeletal muscle neoplasm arising from the cervix. It is characterized by the presence of small nucleated rhabdomyoblasts within a fibrous and myxoid stroma.


Benign Cervical Soft Tissue Neoplasm

description: A rare benign mesenchymal neoplasm that arises from the cervix.


Cervical Leiomyoma

description: An uncommon benign smooth muscle neoplasm that arises from the cervix.


name: Metastatic Prostate Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the prostate gland and has spread to other anatomic sites.


name: Metastatic Prostate Small Cell Neuroendocrine Carcinoma

description: Prostate small cell neuroendocrine carcinoma that has spread to another anatomic site.


name: Advanced Prostate Small Cell Neuroendocrine Carcinoma

description: Prostate small cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Locally Advanced Prostate Neuroendocrine Carcinoma

description: A prostate neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


central nervous system mature teratoma

description: A teratoma composed exclusively of fully differentiated, 'adult-type' tissue elements that are sometimes arranged in a pattern resembling normal tissue relationships. Mitotic activity is low or absent. The more common ectodermal components present in a mature teratoma include skin, brain and choroid plexus. The more common mesodermal components include cartilage, bone, fat and muscle (both smooth and striated). And the most common endodermal components are cysts lined by epithelia of respiratory or enteric type and in some cases pancreatic or hepatic tissue. (Adapted from WHO)


extragonadal germ cell tumor

description: A germ cell tumor arising in an anatomic site other than the testis or ovary (e.g., central nervous system, lung, mediastinum, and retroperitoneum).


name: adult central nervous system germ cell tumor

description: A germ cell tumor of the central nervous system occurring in adults.


name: adult central nervous system immature teratoma


brain germinoma

description: A germinoma (disease) that involves the brain.


central nervous system germ cell tumor

description: A unique group of rare tumors of the central nervous system that affect mainly children and adolescents. Their morphologic and biologic profile corresponds to that of homologous germ cell tumors that arise in the gonads and in other extragonadal sites. Representative examples include: germinoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma.


adult central nervous system germinoma

description: A central nervous system germinoma that occurs in an adult.


gestational choriocarcinoma

description: Gestational choriocarcinoma is a gestational trophoblastic tumor (GTT) occurring secondary to pregnancy (ectopic or normal), miscarriage, voluntary termination of pregnancy (VTP) or a hydatidiform mole.


name: adult central nervous system embryonal carcinoma

description: A embryonal carcinoma of the central nervous system that occurs in an adult.


polyembryoma of the ovary

description: A rare, malignant germ cell tumor arising from the ovary. It is characterized by the presence of embryoid bodies which resemble early embryos.


testicular embryonal carcinoma

description: A malignant germ cell neoplasm arising from the testis. It is composed of primitive epithelial cells arranged in solid, papillary, and glandular configurations. Most patients present with a testicular mass, which may be associated with pain. More than half of the patients have metastatic disease at diagnosis. The form of treatment following radical orchiectomy is stage dependent.


name: testicular yolk sac tumor, solid pattern

description: A yolk sac tumor that arises from the testis and is characterized by the presence of aggregates of polygonal malignant cells with clear cytoplasm and prominent nucleoli.


childhood ovarian yolk sac tumor

description: A yolk sac tumor that arises from the ovary and occurs in children.


pineal region choriocarcinoma

description: A choriocarcinoma (disease) that involves the pineal body.


name: central nervous system immature teratoma

description: A variant of teratoma composed of incompletely differentiated components resembling fetal tissues. Even if the immature component is only a minor element of an otherwise differentiated teratoma, the tumor is still classified as immature. (Adapted from WHO)


ovarian yolk sac tumor

description: A usually rapidly growing malignant germ cell tumor arising from the ovary. It usually occurs in children and adolescents. Signs and symptoms include abdominal pain and a large abdominal or pelvic mass. The serum alpha-fetoprotein is almost always elevated preoperatively. Morphologically, there is marked heterogeneity due to numerous patterns of differentiation coexisting in the same tumor. The most common pattern is reticular.


mediastinal malignant germ cell tumor

description: An extragonadal malignant germ cell tumor that arises from the mediastinum. This category includes seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, mixed germ cell tumors, and immature malignant teratoma.


adult central nervous system teratoma

description: A mature or immature teratoma affecting the central nervous system and occurring in adults.


gestational ovarian choriocarcinoma

description: A rare malignant trophoblastic tumor that arises from the ovary as a result of ectopic ovarian pregnancy. There is no germ cell component present.


name: choriocarcinoma of the central nervous system

description: A malignant germ cell tumor of the central nervous system characterized by extra-embryonic differentiation along trophoblastic lines. The diagnosis requires the identification of cytotrophoblastic elements, as well as syncytiotrophoblastic giant cells. (WHO)


mediastinal yolk sac tumor

description: An extragonadal non-seminomatous malignant germ cell tumor that arises from the mediastinum. It is characterized by the presence of small pale cells with small amount of cytoplasm and round to oval nuclei with small nucleoli forming a variety of patterns, including microcystic, macrocystic, pseudopapillary, myxomatous, hepatoid, polyvesicular vitelline, and solid. It manifests with respiratory distress, thoracic pain, fever, and superior vena cava syndrome.


pineal region dysgerminoma

description: A dysgerminoma (disease) that involves the pineal body.


malignant cardiac germ cell tumor

description: A rare malignant germ cell tumor that arises from the pericardium.


malignant teratoma of mediastinum

description: A malignant teratoma that involves the mediastinum.


mediastinal germ cell tumor

description: A germ cell tumor that arises from the mediastinum. Representative examples include seminoma, embryonal carcinoma, yolk sac tumor, teratoma, and mixed germ cell tumor.


name: polyvesicular vitelline pattern testicular yolk sac tumor

description: A yolk sac tumor that arises from the testis and is characterized by the presence of collections of vesicles that are surrounded by connective tissue.


name: yolk sac tumor of central nervous system

description: A malignant germ cell tumor of the central nervous system composed of primitive-appearing epithelial cells - putatively representing yolk sac endoderm - set in a loose, variably cellular, and often conspicuously myxoid matrix, resembling extra-embryonic mesoblast. Eosinophilic hyaline globules immunoreactive for AFP are a diagnostic feature. (WHO)


name: childhood central nervous system embryonal carcinoma

description: An embryonal carcinoma that arises from the central nervous system and occurs during childhood.


immature extragonadal teratoma

description: An immature teratoma that develops as a primary tumor in an anatomic site other than the testis or ovary.


pineal region germinoma

description: A germinoma that arises from the pineal gland.


name: extragonadal non-dysgerminomatous germ cell tumor


embryonal carcinoma

description: A non-seminomatous malignant germ cell tumor characterized by the presence of large germ cells with abundant cytoplasm resembling epithelial cells, geographic necrosis, high mitotic activity, and pseudoglandular and pseudopapillary structures formation. It can arise from the testis, ovary, and extragonadal sites (central nervous system and mediastinum).


adult yolk sac tumor

description: A yolk sac tumor that occurs in an adult.


name: reticular pattern testicular yolk sac tumor

description: A yolk sac tumor that arises from the testis and is characterized by the presence of a meshwork of small vacuolated cells resulting in a honeycomb appearance.


childhood embryonal testis carcinoma

description: An embryonal carcinoma that arises from the testis during childhood.


name: testicular yolk sac tumor, myxomatous pattern

description: A yolk sac tumor that arises from the testis and is characterized by the presence of myxomatous tissue that contains collections of malignant cells with prominent nucleoli.


name: ovarian yolk sac tumor, glandular pattern

description: A yolk sac tumor that arises from the ovary and is characterized by the presence of extensive differentiation into endodermal type glandular structures.


spinal cord dermoid cyst

description: A dermoid cyst that involves the spinal cord.


malignant peritoneal germ cell tumor

description: A malignant germ cell tumor that affects the peritoneum.


name: testicular yolk sac tumor, macrocystic pattern

description: A yolk sac tumor that arises from the testis and is characterized by the presence of collections of thin-walled spaces.


name: testicular yolk sac tumor, endodermal sinus pattern

description: A yolk sac tumor that arises from the testis and is characterized by the presence of connective tissue stalks that contain a blood vessel and are lined by cells with clear cytoplasm and prominent nucleoli.


name: malignant pineal area germ cell neoplasm

description: A malignant germ cell tumor that arises in the pineal region. Representative examples include germinoma, immature teratoma, choriocarcinoma, embryonal carcinoma and yolk sac tumor.


testicular yolk sac tumor

description: A non-seminomatous malignant germ cell tumor arising from the testis. It affects infants, young children, and postpubertal males. It is the most frequently seen testicular neoplasm during childhood. The vast majority of patients present with an asymptomatic scrotal mass. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). It metastasizes to distant anatomic sites. Prognostic factors relate to the clinical stage and the degree of AFP elevation.