AURINTRICARBOXYLIC ACID

A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.


A member of the class of quinazolines that is quinazoline which is substituted at positions 2 and 4 by phenyl and (3-acetamidophenyl)nitrilo groups, respectively.


name: 3-(2-Pyridin-3-yl-quinazolin-4-ylamino)-benzoic acid methyl ester


RETUSIN

A monohydroxyflavone that is 5-hydroxyflavone which is substituted by methoxy groups at positions 3,3',4' and 7.


AYANIN

A trimethoxyflavone that is  quercetin in which the hydroxy groups at positions 3, 4' and 7 have been replaced by methoxy groups.


A member of the class of quinazolines that is quinazoline which is substituted by a (3-methoxyphenyl)nitrilo group at position 4.


A  methoxyaurone that is  aureusidin in which the hydroxy groups at positions  4, 6, 3' and 4' have been replaced by methoxy groups respectively. It has been isolated from the roots of Cyperus teneriffae.


A macrolide that is a 14-memebered macrocycle fused to a 1,3-dihydroxybenzene. Isolated from Fungi, it exhibits inhibitory activity against  NF-kappaB.


kaempferol 3-O-beta-L-glucopyranoside

A kaempferol O-glucoside that is  kaempferol attached to a beta-L-glucopyranosyl moiety at position 3 via a glycosidic linkage.


GSK547 (GSK'547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIPK1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.


TOPOPYRONE C

A naphthochromene that is 4H-naphtho[2,3-h]chromene-4,7,12-trione substituted by hydroxy groups at positions 5, 9 and 11 and a methyl group at position 2. It is isolated from fungal strains Phoma and Penicillium and acts as an inhibitor of the enzyme topoisomerase I.


A sulfonamide resulting from the formal condensation of the sulfonic acid group of 5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonic acid with the primary amino group of piperidin-4-amine. An inhibitor of secreted Frizzled-Related Protein-1 (sFRP-1).


A member of the class of quinazolines that is quinazoline which is substituted at positions 2, 5 and 8 by 2-amino-1H-benzimidazol-1-yl, benzylnitrilo and methoxy groups, respectively. It is a ATP-competetive inhibitor of AAA ATPase p97, also known as valosin-containing protein (VCP).


ERASTIN

A member of the class of quinazolines that is quinazolin-4(3H)-one in which the hydrogens at positions 2 and 3 are replaced by 1-{4-[(4-chlorophenoxy)acetyl]piperazin-1-yl}ethyl and 2-ethoxyphenyl groups, respectively. It is an inhibitor of voltage-dependent anion-selective channels (VDAC2 and VDAC3) and a potent ferroptosis inducer.


A monochlorobenzene that is benzene substituted by (chloroacetyl){2-oxo-2-[(2-phenylethyl)amino]-1-(thiophen-2-yl)ethyl}amino, chloro and methoxy groups at positions 1, 3 and 4, respectively. It is a covalent inhibitor of glutathione peroxidase 4 (GPX4) that induces ferroptosis in cells.


DEHYDROABIETIC ACID

An abietane diterpenoid that is abieta-8,11,13-triene substituted at position 18 by a carboxy group.


triclosan

An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.


lucanthone

A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone.


sulforaphane

An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.


(R)-sulforaphane

A sulforaphane in which the sulfinyl group has R configuration. Naturally occurring compound found in brocolli that acts as a potent inducer of phase II detoxification enzymes.


NUMIDARGISTAT

An aminopyrrolidine that is pyrrolidine substituted by (2S)-2-aminopropanoyl, amino, carboxy, and 3-boronopropyl groups at positions 1, 3, 3, and 4 (the 3R,4S-stereoisomer). It is a selective arginase inhibitor being developed by Calithera Biosciences for the treatment of solid tumours.


L-cysteine substituted at sulfur by a 2-boronoethyl group.


name: 4-[1-(4-Methanesulfonyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy]-piperidine-1-carboxylic acid ethyl ester


name: 4-[1-(4-Methanesulfonyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylsulfanyl]-piperidine-1-carboxylic acid tert-butyl ester


name: 4-[5-(2-Fluoro-4-methanesulfonyl-phenyl)-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester


name: 4-[6-(2-Fluoro-4-methanesulfonyl-phenoxy)-5-methyl-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester


name: 4-[5-(2-Fluoro-4-methanesulfonyl-phenyl)-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid isopropyl ester


name: 2,6-Diazatricyclo[3.3.1.13,7]decane-2-carboxylic acid, 6-[6-[2-fluoro-4-(1H-tetrazol-1-yl)phenoxy]-5-Methyl-4-pyriMidinyl]-, 1-Methylcyclopropyl ester


name: 4-[6-(2-Fluoro-4-methanesulfonyl-phenylamino)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester


name: 4-[9-(4-Methanesulfonyl-phenyl)-9H-purin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester


name: 4-[5-(4-Ethylcarbamoyl-phenyl)-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester


name: 4-[5-(4-Methanesulfonylphenyl)furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid tert-butyl ester


name: 4-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester


name: 4-[5-(4-Methanesulfonyl-piperazin-1-yl)-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester


LEPTOMYCIN B

A leptomycin having a (2E,10E,12E,16Z,18E)-double bond configuration as well as an ethyl substituent at position 17.


CHLOROPEPTIN

A heterodetic cyclic peptide consisting of N-acylated trytophan, 3,5-dichloro-4-hydroxyphenylglycine, 4-hydroxyphenylglycine, 3,5-dichloro-4-hydroxyphenylglycyl, tyrosine and 4-hydroxyphenylglycine residues joined in sequence and in which the side-chain of the central 4-hydroxyphenylglycine residue is attached to the side-chain of the tryptophan via a C3-C7 bond and to the side-chain of the tyrosine via an ether bond from C5. It is isolated from the culture broth of Streptomyces and has anti-HIV-1 activity.


A member of the class of indazoles that is 1H-indazole that is substituted at position 3 by a 6-(cis-2,6-dimethylmorpholin-4-yl)pyrimidin-4-yl group and at position 5 by a (1-methylcyclopropoxy)group. It is an inhibitor of leucine-rich repeat kinase 2 (LRRK2).


chlorhexidine

A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.


α-ketoglutaric acid

An oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. It is an intermediate metabolite in Krebs cycle.


brivanib alinate

A carboxylic ester resulting from the formal condensation of the carboxy group of L-alanine with the hydroxy group of brivanib. It is a prodrug of brivanib (BMS-540215), a potent oral dual inhibitor of VEGFR-2 and FGFR-1 (IC50 of 25 nM and 148 nM, respectively) and was in development for the treatment of hepatocellular and colon carcinomas.


3-(1H-imidazol-1-yl)propanoic acid

An imidazolyl carboxylic acid that is propanoic acid in which one of the methyl hydrogens is substituted by an imidazol-1-yl group. It is a metabolite of histidine found in human urine and faeces.


iptacopan

A member of the class of indoles that is 1H-indole substituted by [(2S,4S)-2-(4-carboxyphenyl)-4-ethoxypiperidin-1-yl]methyl, methoxy, and methyl groups at positions 4, 5, and 6, respectively. It is a potent inhibitor of complement factor B (IC50 = 10nM) with potential immunomodulatory activity.


name: 2-[6-(4-Chlorophenoxy)-1,1-difluorohexyl]-2-oxiranecarboxylic acid sodium salt


promegestone

A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.


name: Acetic acid 5-bromo-2-((1S,6R)-4,6-dimethyl-2-methylene-cyclohex-3-enylmethyl)-4-methoxy-phenyl ester


name: Acetic acid 5-bromo-4-methoxy-2-(4,6,6-trimethyl-2-methylene-cyclohex-3-enylmethyl)-phenyl ester


name: Acetic acid 5-bromo-4-methoxy-2-(5,5,7-trimethyl-spiro[2.5]oct-7-en-4-ylmethyl)-phenyl ester


name: 4-[5-(2-phenylethyl)-2-sulfanylidene-1,3,5-triazinan-1-yl]benzoic acid ethyl ester


A cholestanoid that consists of cholesterol bearing an oxo substituent at position 7.


name: Prostaglandin D synthase (hematopoietic-type) inhibitor F092


DISOGLUSIDE

A sterol 3-beta-D-glucoside having diosgenin as the sterol component.


A glycosyloxyisoflavone that is calycosin substituted by a beta-D-glucopyranosyl residue at position at 7 via a glycosidic linkage.


A leucine derivative obtained by fpormal condensation of the secondary amino group of 5-({2,3-dichloro-4-[1-methyl-5-(piperidin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)-2-furoic acid and the carboxy group of N-amidino-L-leucylglycine


ONONIN

A 4'-methoxyisoflavone that is formononetin attached to a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.


keto-D-fructose 1,6-bisphosphate

A ketohexose bisphosphate that is D-fructose substituted by phosphate groups at positions 1 and 6.


name: Carbamic acid, [5-[(4-phenyl-1-piperidinyl)methyl]-2-thiazolyl]-, methyl ester


A dipeptide formed from L-arginine and L-phenylalaninamide residues in which a hydrogen attached to the nitrogen of the alpha-amino group of the arginine residue has been replaced by a 1-adamantanecarbonyl group. It has been reported to be a potent and selective antagonist of neuropeptide FF (NPFF) receptors, but more recently found to be an agonist at both NPFF1R and the kisspeptin receptor (KISS1R).


name: PHOSPHOMETHYLPHOSPHONIC ACID GUANOSYL ESTER


name: 4-(6-Benzyl-4,5-dimethyl-pyridazin-3-yl)-piperazine-1-carboxylic acid phenyl ester


(-)-Epicatechin

A catechin with (2R,3R)-configuration.


ISOLITHOCHOLIC ACID

A monohydroxy-5beta-cholanic acid with a beta-hydroxy substituent at position 3. The 3beta-hydroxy epimer of lithocholic acid.


name: 3-(4-Hydroxyphenyl)Acrylic Acid Phenpropyl Ester


BISDEMETHOXYCURCUMIN

A beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups.


name: 2-Propenoic acid, 3-(4-hydroxyphenyl)-, 2-phenylethyl ester, (2E)-


MASLINIC ACID

A pentacyclic triterpenoid that is olean-12-ene substituted by hydroxy groups at positions 2 and 3 and a carboxy group at position 28 (the 2alpha,3beta stereoisomer). It is isolated from Olea europaea and Salvia canariensis and exhibits anti-inflammatory, antioxidant and antineoplastic activity.


name: 11H-dibenzo[b,e]azepine-10-carboxylic acid butyl ester hydrochloride


name: 11H-Dibenzo[b,e]azepine-3-carboxylic acid methyl ester


name: 11H-dibenzo[b,e]azepine-4-carboxylic acid methyl ester


name: 11H-Dibenzo[b,e]azepine-7-carboxylic acid methyl ester


PHENETHYLISOTHIOCYANATE

An isothiocyanate having a phenethyl group attached to the nitrogen. It is a naturally occurring compound found in some cruciferous vegetables (e.g. watercress) and is known to possess anticancer properties.


ALLITRIDIN

An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity


A isothiocyanate that is hexane in which two of the terminal methyl hydrogens at positions 1 and 6 have been replaced by isothiocyanato and methylsulfanyl groups.


name: 11H-dibenzo[b,e]azepine-8-carboxylic acid isopropyl ester


name: Ethanethioic acid, S-[2,2,2-trichloro-1-[(4-chlorobenzoyl)amino]ethyl] ester


A methylcatechol carrying a methyl substituent at position 3. It is a xenobiotic metabolite produced by some bacteria capable of degrading nitroaromatic compounds present in pesticide-contaminated soil samples.


A 2-pentenal in which the double bond has (E)-configuration. It is found in cigarette smoke, virgin olive oil, and milk.


DIALLYLDISULFIDE

An organic disulfide where the organic group specified is allyl. It has been isolated from garlic and other species of the genus Allium.


VOACANGINE

A monoterpenoid indole alkaloid with formula C22H28N2O3, isolated from several plant species.


CATHARANTHINE BASE

An organic heteropentacyclic compound and monoterpenoid indole alkaloid produced by the medicinal plant Catharanthus roseus via strictosidine.


TOLUENE DIISOCYANATE

A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.


name: 4-{5-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]pyridin-2-yl}piperazine-1-carboxylic Acid Methyl Ester


name: 4-{5-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]pyridin-2-yl}piperazine-1-carboxylic Acid Ethyl Ester


name: 4-{5-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)amino]-pyrimidin-2-yl}piperazine-1-carboxylic Acid Methyl Ester


name: 4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]phenyl}piperidine-1-carboxylic Acid Methyl Ester


name: 4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]phenyl}piperazine-1-carboxylic Acid Methyl Ester


sinefungin

An adenosine that is the the delta-(5'-adenosyl) derivative of ornithine.


GLIOTOXIN

A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.


aldrithiol

A member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols.


NANAFROCIN

A pyranonaphthoquinone antibiotic from strain OS-3966 of Streptomyces rosa var. notoensis.


ipriflavone

A member of the class of isoflavones that is isoflavone in which the hydrogen at position 7 is replaced by an isopropoxy group. A synthetic isoflavone, it was formerly used for the treatment of osteoporosis, although a randomised controlled study failed to show any benefit. It is still used to prevent osteoporosis in post-menopausal women.


name: 4-(5-formyl-2-furanyl)benzoic acid propyl ester


sonolisib

An organic heterotetracyclic compound that is obtained from wortmanin via aminolysis of its furan ring by diallyl amine.


ROSMARINIC ACID

A stereoisomer of rosmarinic acid having (R)-configuration.


ceftriaxone

A third-generation cephalosporin compound having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups.


FERULATE

A ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 3 and 4 respectively on the phenyl ring.


A dicarboximide having an exo bridged phthalimide structure, substituted at nitrogen by a 4-(quinolin-8-ylcarbamoyl)benzoyl group. It is a weak axin stabilizer, an analogue of  IWR-1-endo.


A dicarboximide having an endo bridged phthalimide structure, substituted at nitrogen by a 4-(quinolin-8-ylcarbamoyl)benzoyl group.


tranilast

An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group.


SULFOBROMOPHTHALEIN SODIUM

An organic sodium salt that is the disodium salt of bromosulfophthalein.


OLIGOMYCIN

An oligomycin with formula C45H74011. An inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types and exhibits antifungal, antitumour, and nematicidal activities, but its clinical application has been limited by poor solubility in water and other biocompatible solvents.


LASALOCID A SODIUM

The sodium salt of lasalocid. It is a veterinary ionophore antibiotic used for prevention and treatment of coccidiosis in poultry.


betacarotene

A cyclic carotene obtained by dimerisation of all-trans-retinol. A strongly-coloured red-orange pigment abundant in plants and fruit and the most active and important provitamin A carotenoid.


ATORVASTATIN CALCIUM

An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.


bilirubin

A member of the class of  biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin.


name: N-methyl-N-[3-(2-methylphenoxy)-3-phenylpropyl]carbamic acid phenyl ester


muramyl dipeptide

A glycopeptide that is N-propionyl-L-alanyl-D-alpha-glutamine in which the pro-R hydrogen of the propionyl group has been replaced by the oxygen at position 3 of 2-acetamido-2-deoxy-beta-D-glucopyranose. A peptidoglycan constituent of both Gram-positive and Gram-negative bacteria.


cromoglicic acid

A  dicarboxylic acid that is the bis-chromone derivative of glycerol. It is effective as a mast cell stabilizer.


tubercidin

An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus.


A member of the class of 2,6-diaminopurines that is 2,6-diamiopurine which is substituted by an isopropyl group at position 9 and in which the amino groups at positions 2 and 6 are substituted by a 1-hydroxybutan-2-yl and 3-(pyridin-2-yl)phenyl groups, respectively (the R enantiomer). A cyclin dependent kinase inhibitor, widely used as its hydrochloride hydrate.


name: 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester


Ro 48-8071 fumarate

A fumarate salt obtained by combining Ro 48-8071 with one molar equivalent of fumaric acid. An inhibitor of lanosterol synthase.


name: Trans-Methyl-{4-[5-(methyl-propyl-amino)-pent-1-ynyl]-cyclohexyl}-carbamic acid 4-chloro-phenyl ester.fumarate


name: Trans-(4-{5-[Ethyl-(2-hydroxy-ethyl)-amino]-pent-1-ynyl}-cyclohexyl)-carbamic acid 4-chloro-phenyl ester hydrochloride


name: Methyl-[4-(4-piperidin-1-ylmethyl-phenyl)-cyclohexyl]-carbamic acid 4-chloro-phenyl ester


name: Trans-[2-(4-{[Ethyl-(2-hydroxy-ethyl)-amino]-methyl}-cyclohexyl)-ethyl]-methyl carbamic acid 4-trifluoromethyl-phenyl ester citrate


name: Methyl-{4-[4-(1-oxy-piperidin-1-ylmethyl)-phenyl]-cyclohexyl}-carbamic acid 4-chloro-phenyl ester


name: [(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-2,2-dimethyl-propyl]-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Formyl-2-methyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Benzyl-2-benzyloxycarbamoyl-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: {(S)-1-[(S)-1-(4-Benzyloxy-benzyl)-2-oxo-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3-methyl-butyl]-carbamic acid 4-nitro-benzyl ester


name: [(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


A dipeptide resulting from the formal condensation of the carboxy group of N-benzyloxycarbonyl-L-valine with the amino group of L-phenylalanine aldehyde. It is a potent cell-permeable inhibitor of calpain I and II, and is also a gamma-secretase inhibitor.


name: [(S)-1-((S)-1-Benzyl-2-methoxycarbamoyl-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [(S)-1-(1-Formyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


A dipeptide formed from L-valine and L-phenylalanine residues.


name: [(S)-1-((S)-1-Cyclohexylmethyl-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3-methyl-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester


name: [(R)-1-((S)-1-Benzyl-2-benzyloxycarbamoyl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3-methyl-butyl]-carbamic acid methyl ester


name: Benzenesulfonic acid (3R,5S)-1-benzenesulfonyl-5-((S)-1-benzyl-2-oxo-ethylcarbamoyl)-pyrrolidin-3-yl ester


name: {(S)-1-[(S)-1-Formyl-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Benzyl-2-ethoxycarbamoyl-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Benzyloxyaminooxalyl-pentylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Benzyl-2-tert-butoxycarbamoyl-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Ethylcarbamoyl-butylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [1-((4S,5R)-4-Benzyl-5-hydroxy-oxazolidine-3-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-pentyl]-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Formyl-2,2-dimethyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Ethylcarbamoyl-2-phenyl-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [1-(1-Benzyl-2-oxo-2-phenethylcarbamoyl-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [(S)-1-(1-Ethylcarbamoyl-butylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [(S)-1-(1-Ethylcarbamoyl-2-phenyl-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [(S)-1-(3-Ethylcarbamoyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: (1-{1-Benzyl-2-oxo-2-[(quinolin-2-ylmethyl)-carbamoyl]-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-2-(1H-indol-3-yl)-ethyl]-carbamic acid benzyl ester


name: [(S)-3-Methyl-1-((S)-1-methyl-2-oxo-ethylcarbamoyl)-butyl]-carbamic acid benzyl ester


name: {1-[1-Benzyl-2-(3-morpholin-4-yl-propylcarbamoyl)-2-oxo-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3,3-dimethyl-butyl]-carbamic acid benzyl ester


name: [(S)-1-(3-Ethylcarbamoyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid tert-butyl ester


name: [(1S,2S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-2-hydroxy-propyl]-carbamic acid benzyl ester


name: [1-(1-Benzylaminooxalyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [3-Methyl-1-(1-phenethylaminooxalyl-propylcarbamoyl)-butyl]-carbamic acid benzyl ester


name: [1-(1-Benzyl-2-ethylcarbamoyl-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


An organoiodine compound that is acrylic acid in which the vinylic hydrogens at positions 2 and 3 are replaced by mercapto and 4-iodophenyl groups respectively (the Z geoisomer).


name: [(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester


name: [(S)-1-(1-Ethylaminooxalyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: {3-Methyl-1-[1-(3-morpholin-4-yl-propylaminooxalyl)-butylcarbamoyl]-butyl}-carbamic acid benzyl ester


name: [3-Methyl-1-(1-methylaminooxalyl-propylcarbamoyl)-butyl]-carbamic acid benzyl ester


name: [(S)-3-Methyl-1-(2-oxo-ethylcarbamoyl)-butyl]-carbamic acid benzyl ester


name: [1-(1-Benzyl-2-oxo-2-propylcarbamoyl-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [1-(1-Benzyl-2-methylcarbamoyl-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [(S)-3-Carbamoyl-1-((S)-1-formyl-3-methyl-butylcarbamoyl)-propyl]-carbamic acid benzyl ester


name: [(R)-2-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoyl]-phenyl-phosphinic acid ethyl ester


name: {1-[((S)-1-Formyl-2-phenyl-ethyl)-hydroxymethyl-carbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester


name: {1-[((S)-1-Formyl-2-phenyl-ethyl)-methyl-carbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester


name: {1-[1-(5-Hydroxy-pentylaminooxalyl)-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester


name: [(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-2-hydroxy-ethyl]-carbamic acid benzyl ester


name: [(S)-2-Cyclohexyl-1-((S)-1-formyl-3-methyl-butylcarbamoyl)-ethyl]-carbamic acid benzyl ester


name: (R)-2-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoic acid ethyl ester


name: (1-{1-Benzyl-2-oxo-2-[(pyridin-2-ylmethyl)-carbamoyl]-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester


name: {1-[1-(Cyclohexylmethyl-aminooxalyl)-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester


GSK805 is an orally active and CNS penetrant RORgammat inhibitor. GSK805 inhibits RORgamma and Th17 cells differentiation. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity.


TMP778 is a potent and selective RORgt inverse agonist.


An oxysterol that is the 22S-hydroxy derivative of cholesterol.


An oxysterol that is cholesterol substituted at position 26 by a hydroxy group.


cholesterol

A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.


An oxysterol that is cholesterol substituted by a hydroxy group at position 20.


A carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor).


atazanavir

A heavily substituted carbohydrazide that is an antiretroviral drug of the protease inhibitor (PI) class used to treat infection of human immunodeficiency virus (HIV).


cefsulodin

A pyridinium-substituted semi-synthetic, broad-spectrum, cephalosporin antibiotic.


An oxoicosatetraenoic acid having a 5-oxo group; and (6E)-, (8Z), (11Z)- and (14Z)-double bonds.


ditiocarb

A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur.


TOLONIUM CHLORIDE

An organic chloride salt having 3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium (tolonium) as the counterion.  It is a blue nuclear counterstain that can be used to demonstrate Nissl substance and is also useful for staining mast cell granules, both in metachromatic and orthochromatic techniques.


thionine

An organic chloride salt composed of 3,7-diaminophenothiazin-5-ium and chloride ions in a 1:1 ratio. A strongly metachromatic dye, useful for the staining of acid mucopolysaccharides. It is also a common nuclear stain and can be used for the demonstration of Nissl substance in nerve cells of the CNS.


colchicine

An  alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum.


A triazolopyrimidine that consists of 3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidine bearing amino and oxo substituents at positions 5 and 7 respectively.


azaleatin

A monomethoxyflavone that is quercetin in which the hydroxy group at position 5 is replaced by a methoxy group.


cefamandole

A cephalosporin compound having (R)-mandelamido and N-methylthiotetrazole side-groups.


cefazolin

A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively.


cefoperazone

A semi-synthetic parenteral cephalosporin with a tetrazolyl moiety that confers beta-lactamase resistance.


cefaloridine

A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C.


cefotaxime

A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.


A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and benzyl groups, respectively. It is a potent inhibitor of mutant isocitrate dehydrogenase 1 (Ki values of 190 nM against R132H mutant and 120 nM against R132C mutant).


DIGOXIGENIN

A hydroxy steroid that consists of 5beta-cardanolide having a double bond at the 20(22)-position as well as hydroxy groups at the 3beta-, 12beta- and 14beta-positions. It has been isolated from the plant species of the genus Digitalis.


PROSTAGLANDIN D2

A member of the class of  prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- stereoisomer).


name: GUANOSINE 5'-(TETRAHYDROGEN TRIPHOSPHATE), 7-METHYL-, INNER SALT, P''->5'-ESTER WITH GUANOSINE


7-methylguanosine 5'-diphosphate

A guanosine 5'-phosphate that consists of guanosine 5'-diphosphate bearing a 7-methyl substituent and having a negatively charged diphosphate group.


A 1-acyl-sn-glycero-3-phospho-1D-myo-inositol in which the 1-acyl group is specified as stearoyl.


name: PJ-34 hydrochloride hydrate, >=98% (HPLC), powder


ARV-825 is a PROTAC connected by ligands for Cereblon and BRD4. ARV-825 binds to BD1 and BD2 of BRD4.


HEDERAGENIN

A sapogenin that is olean-12-en-28-oic acid substituted by hydroxy groups at positions 3 and 23 (the 3beta stereoisomer).


Trp-Trp

A dipeptide formed from two L-tryptophan residues.


An organic iodide salt consisting of pyridinium iodide having a methyl substituent at the 1-position and a 4-dimethylaminostyryl substituent at the 4-position.


HISPIDULIN

A monomethoxyflavone that is scutellarein methylated at position 6.


name: Benzenesulfonic acid, p-methyl-, 2-phenylhydrazide


name: (3r,5r)-7-[5-Carbamoyl-3-(4-fluoro-phenyl)-1-isopropyl-4-phenyl-1h-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid sodium salt


meglutol

A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.


PRAVASTATIN SODIUM

An organic sodium salt that is the sodium salt of pravastatin. A reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA), it is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.


α-asarone

The trans-isomer of  asarone.


SILVESTROL

An organic heterotricyclic compound that consists of a  2,3,3a,8b-tetrahydro-H-benzo[b]cyclopenta[d]furan framework substituted by hydroxy groups at positions C-1 and C-8b, a methoxycarbonyl group at C-2, a phenyl group at C-3, a 4-methoxyphenyl group at C-3a, a methoxy group at C-8 and a 1,4-dioxan-2-yloxy group at position C-6 which in turn is substituted by a methoxy group at position 3 and a 1,2-dihydroxyethyl group at position 6. Isolated from Aglaia silvestris, it exhibits antineoplastic activity.


AGLAFOLIN

A heterotricyclic compound based on a 2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan framework substituted by hydroxy groups at positions C-1 and C-8b, a methoxycarbonyl group at C-2, a phenyl group at C-3, a 4-methoxyphenyl group at C-3a and methoxy groups at C-6 and C-8. A platelet aggregation inhibitor found in Aglaia elliptifolia and Aglaia odorata.


cycloheximide

A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon  bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.


An organic sulfate that is the 3-O-sulfate derivative of trans-resveratrol.


TRYPROSTATIN A

A cyclic dipeptide that is brevianamide F (cyclo-L-Trp-L-Pro) substituted at positions 2 and 6 on the indole ring by prenyl and methoxy groups respectively.


nitrofurantoin

An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.


name: 5-hydroxy-2-[[(4-methylphenyl)thio]methyl]-3-benzofurancarboxylic acid ethyl ester


name: 2-Acetylamino-4-methyl-pentanoic acid [1-(benzothiazole-2-carbonyl)-4-guanidino-butyl]-amide; TFA


dithranol

An anthracene compound derived by the substitution of -OH groups for hydrogen at C-1 and C-8, and with an oxo group at C-9.


NMDA

An aspartic acid derivative having an N-methyl substituent and D-configuration.


pevonedistat

A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine which is substituted by a (1S)-2,3-dihydro-1H-inden-1-ylnitrilo group at position 4 and by a (1S,3S,4S)-3-hydroxy-4-[(sulfamoyloxy)methyl]cyclopentyl group at position 7. It is a potent and selective NEDD8-activating enzyme inhibitor with an IC50 of 4.7 nM, and currently under clinical investigation for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes.


A monocarboxylic acid amide obtained by the formal condensation of the terminal amino group of 3-amino-L-alanine with the carboxy group of (2E)-4-methoxy-4-oxobut-2-enoic acid.


name: (2S)-5-(2-Chloroethanimidamido)-2-(phenylformamido)pentanamide trifluoroacetic acid salt


STREPTONIGRIN

Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.


SULFENTRAZONE

A member of the class of triazoles that is 5-oxo-1,2,4-triazole which is substituted at positions 1, 3, and 4 by 2,4-dichloro-5-[(methylsulfonyl)amino]phenyl, methyl, and difluoromethyl groups, respectively. A protoporphyrinogen oxidase inhibitor, it is used as a herbicide to control broad-leaved weeds in soya and tobacco crops. Not approved for use within the European Union.


SUCCINYLACETONE

A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.


name: [1-(1-Aminooxalyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [3-Methyl-1-(1-octylaminooxalyl-propylcarbamoyl)-butyl]-carbamic acid benzyl ester


name: {1-[1-(3,5-Dimethoxy-benzylaminooxalyl)-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester


name: [1-(1-Benzyl-2-butylcarbamoyl-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [1-(1-Benzyl-2-benzylcarbamoyl-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: {1-[1-Benzyl-2-(2-hydroxy-2-phenyl-ethylcarbamoyl)-2-oxo-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester


name: [1-(1-Butylaminooxalyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [1-(1-Benzyl-2-isobutylcarbamoyl-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [1-(1-Heptylaminooxalyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [1-(1-Aminooxalyl-butylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [1-(1-Ethylaminooxalyl-butylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [1-(1-Isobutylaminooxalyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: 3-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-2-oxo-heptanoic acid ethyl ester


name: 3-(2-Diphenylacetylamino-4-methyl-pentanoylamino)-2-oxo-pentanoic acid ethyl ester


name: [3-Methyl-1-(1-propylaminooxalyl-propylcarbamoyl)-butyl]-carbamic acid benzyl ester


name: 3-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-(4-chloro-phenyl)-2-oxo-butyric acid ethyl ester


name: 3-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-2-oxo-pentanoic acid butyl ester


name: 3-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-2-oxo-pentanoic acid ethyl ester


name: 3-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-2-oxo-4-phenyl-butyric acid ethyl ester


name: 3-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-2-oxo-pentanoic acid benzyl ester


name: 3-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-2-oxo-pentanoic acid methyl ester


name: [1-(1-Decylaminooxalyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: [1-(1-Benzyl-2-carbamoyl-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


name: 4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-(3,6-dihydro-2H-pyridin-1-ylmethyl)-piperazine-1-carboxylic acid methyl ester


A monocarboxylic acid amide obtained by formal condensation between the carboxy group of phenylacetic acid and the secodary amino group of (5R,7S,8S)-N-methyl-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-amine.


name: 4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-(3-oxo-pyrrolidin-1-ylmethyl)-piperazine-1-carboxylic acid methyl ester


name: 4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-dimethylaminomethyl-piperazine-1-carboxylic acid methyl ester


name: 4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-pyrrolidin-1-ylmethyl-piperazine-1-carboxylic acid ethyl ester


name: (1-{1-[2-(3,4-Dichloro-phenyl)-acetyl]-piperidin-2-ylmethyl}-pyrrolidin-3-ylidene)-acetic acid methyl ester


name: 1-{1-[2-(3,4-Dichloro-phenyl)-acetyl]-piperidin-2-ylmethyl}-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester


name: salvinorin B 2,2,2-trifluoroethoxymethyl ether


AKUAMMICINE

A monoterpenoid indole alkaloid with formula C20H22N2O2, isolated from several plant species including Alstonia spatulata, Catharanthus roseus and Vinca major.


name: {[Methyl-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-carbamoyl]-methyl}-carbamic acid benzyl ester


(R)-BICALUTAMIDE

A N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide that is the (R)-enantiomer of bicalutamide.


name: 5-[3-(4-Cyano-3-trifluoromethyl-phenoxy)-4,4-dimethyl-2-oxo-pyrrolidin-1-ylmethyl]-furan-2-carboxylic acid ethyl ester


name: 4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyrimidin-2-yl-piperazin-1-yl)-ethyl ester


name: 1H-indole-3-carboxylic acid 1-(3-carboxy-propyl)-piperidin-4-ylmethyl ester


name: 4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyridazin-3-yl-piperazin-1-yl)-ethyl ester


name: 4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyridin-2-yl-piperazin-1-yl)-ethyl ester


name: 4-Amino-5-chloro-2-methoxy-benzoic acid 2-[4-(6-chloro-pyridazin-3-yl)-piperazin-1-yl]-ethyl ester


name: 4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyridin-4-yl-piperazin-1-yl)-ethyl ester


name: 4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyrimidin-5-yl-piperazin-1-yl)-ethyl ester


name: 4-Amino-5-chloro-2-methoxy-benzoic acid 2-[4-(2-chloro-pyrimidin-5-yl)-piperazin-1-yl]-ethyl ester


name: 4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-phenyl-piperazin-1-yl)-ethyl ester


name: 4-Amino-5-chloro-2-methoxy-benzoic acid 2-[4-(11-amino-undecanoylamino)-piperidin-1-yl]-ethyl ester


name: 4-Amino-5-chloro-2-methoxy-benzoic acid 2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-ethyl ester


name: 4-Amino-5-chloro-2-methoxy-benzoic acid 2-[4-(4-methoxy-phenyl)-piperazin-1-yl]-ethyl ester


name: 4-Amino-5-chloro-2-methoxy-benzoic acid 2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethyl ester


name: 4-[2-(4-Amino-5-chloro-2-methoxy-benzoyloxy)-ethyl]-piperazine-1-carboxylic acid ethyl ester


name: 4-Amino-5-chloro-2-methoxy-benzoic acid 2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl ester


ritodrine

A 4-[2-[[1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol that has (1S,2R)-configuration.


A sulfonamide in which the nitrogen carries methyl and 2-oxo-2-[4-(pyridin-2-yl)piperazin-1-yl substituents and the sulfonyl a p-tolyl group.


name: (4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxy)-acetic acid methyl ester


A sulfonamide in which the nitrogen is the piperidinyl nitrogen of a 2-(pyridin-3-yl)piperidin-1-yl group and the sulfonyl sulfur carries a 4-acetamidophenyl substituent.


name: Methanesulfonic acid (R)-3-{2-[(R)-2-(3-benzoylamino-phenyl)-2-hydroxy-ethylamino]-propyl}-1H-indol-7-yl ester


nipecotic acid

A piperidinemonocarboxylic acid that is piperidine in which one of the hydrogens at position 3 is substituted by a carboxylic acid group.


TIAGABINE HYDROCHLORIDE

A hydrochloride resulting from the reaction of equimolar amounts of tiagabine and hydrogen chloride. A GABA reuptake inhibitor, it is used for the treatment of epilepsy.


AKUAMMIGINE

A monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from Vinca sardoa and Uncaria rhynchophylla.


name: 7-METHYL-8-OXO-5-P-TOLYL-7,8-DIHYDRO-[1,7]NAPHTHYRIDINE-6-CARBOXYLIC ACID (3,5-BIS-TRIFLUOROMETHYL-BENZYL)-METHYL-AMIDE (STRUCTURAL MIX)


name: [1-Dimethylaminomethyl-2-(1H-indol-3-yl)-1-(1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester


name: Carbamic acid, N-((1R)-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-(((1S)-1-phenylethyl)amino)ethyl)-, 2-benzofuranylmethyl ester


name: [2-(1H-Indol-3-yl)-1-methoxymethyl-1-(1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester


name: [2-(1H-Indol-3-yl)-1-(1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester


name: 7-METHYL-8-OXO-5-P-TOLYL-7,8-DIHYDRO-[1,7]NAPHTHYRIDINE-6-CARBOXYLIC ACID (S)-[(S)-1-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-ETHYL]-METHYL-AMIDE (ENANTIOMERIC MIX)


name: [1-(1H-Indol-3-ylmethyl)-1-(1-phenyl-ethylcarbamoyl)-butyl]-carbamic acid benzofuran-2-ylmethyl ester


name: [1-(1H-Indol-3-ylmethyl)-1-(1-phenyl-ethylcarbamoyl)-propyl]-carbamic acid benzofuran-2-ylmethyl ester


name: [(2S,3S)-2-(3,5-Bis-trifluoromethyl-benzyloxy)-3-phenyl-morpholin-4-yl]-acetic acid methyl ester


name: 2-Acetylamino-3-(1H-indol-3-yl)-propionic acid 3,5-bis-trifluoromethyl-benzyl ester


name: 4-[4-(4-Fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexanecarboxylic acid 3,5-bis-trifluoromethyl-benzyl ester


name: (S)-2-Benzoylamino-3-(1H-indol-3-yl)-propionic acid 3,5-bis-trifluoromethyl-benzyl ester


name: [4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phenyl-piperidin-1-yl]-acetic acid methyl ester


name: [1-(1H-Indol-3-ylmethyl)-3-methyl-1-(1-phenyl-ethylcarbamoyl)-butyl]-carbamic acid benzofuran-2-ylmethyl ester


name: (S)-Piperazine-1,2,4-tricarboxylic acid 1-[(3-chloro-phenyl)-phenyl-amide] 2-[(3-diethylamino-propyl)-amide] 4-dipentylamide


name: (S)-Piperazine-1,2,4-tricarboxylic acid 4-dipentylamide 1-diphenylamide 2-{[2-(2-methoxy-benzylamino)-ethyl]-amide}


name: (S)-Piperazine-1,2,4-tricarboxylic acid 4-dipentylamide 1-diphenylamide 2-({2-[(2-methoxy-benzyl)-methyl-amino]-ethyl}-amide)


name: [(2R,4S)-2-Benzyl-1-(3,5-bis-trifluoromethyl-benzoyl)-piperidin-4-yl]-carbamic acid 3-dimethylamino-propyl ester


name: (S)-Piperazine-1,2,4-tricarboxylic acid 2-[(2-diethylamino-ethyl)-amide] 4-dipentylamide 1-diphenylamide


name: (S)-Piperazine-1,2,4-tricarboxylic acid 4-dipentylamide 1-diphenylamide 2-({2-[(2-methoxy-benzyl)-methyl-amino]-ethyl}-methyl-amide)


name: 7-METHYL-8-OXO-5-P-TOLYL-7,8-DIHYDRO-[1,7]NAPHTHYRIDINE-6-CARBOXYLIC ACID (S)-[(R)-1-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-ETHYL]-METHYL-AMIDE (ENANTIOMERIC MIX)


name: (S)-2-Benzoylamino-3-(1H-indol-3-yl)-propionic acid 3,5-dimethyl-benzyl ester


name: (S)-2-Acetylamino-3-(3,4-dichloro-phenyl)-propionic acid 3,5-dimethyl-benzyl ester


name: 4-[1-Phenyl-2-[3,5-bis(trifluoromethyl)benzyloxy]ethyl]-1-piperazineacetic acid methyl ester


name: (S)-Piperazine-1,2,4-tricarboxylic acid 2-[(3-diethylamino-propyl)-amide] 4-dipentylamide 1-diphenylamide


name: (S)-Piperazine-1,2,4-tricarboxylic acid 2-[(2-dimethylamino-ethyl)-amide] 4-dipentylamide 1-diphenylamide


name: (S)-Piperazine-1,2,4-tricarboxylic acid 2-[(2-amino-ethyl)-amide] 4-dipentylamide 1-diphenylamide


name: (S)-2-Benzoylamino-3-(1H-indol-3-yl)-propionic acid 3-trifluoromethyl-benzyl ester


name: [(2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-phenyl-piperidin-1-yl]-oxo-acetic acid methyl ester


name: (S)-3-(1H-Indol-3-yl)-2-methoxycarbonylamino-propionic acid 3,5-dimethyl-benzyl ester


name: 8-(1-Naphthalenylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-3-acetic acid Methyl Ester


name: 6-Chlorothieno [2,3-b]pyridine-2-sulfonic acid {1-[2-fluoro4-(2-oxo-2h-pyridin-1-yl)phenyl]-2-oxopiperidin-3-yl}amide


name: Pyrazole-based inhibitor containing N-arylpiperidiny, 16a


name: 4-(3-Carbamimidoyl-phenoxy)-3-[(2''-sulfamoyl-biphenyl-4-carbonyl)-amino]-benzoic acid methyl ester


name: (2R,3R)-2-(3-Carbamimidoyl-benzyl)-3-(4-imidazol-1-yl-benzoylamino)-butyric acid methyl ester


name: 5-[(2'-Sulfamoyl-4-biphenylyl)carbamoyl]-3-(3-amidinophenyl)-2-isoxazoline-5-acetic acid methyl ester


name: Biphenyl-3,4''-dicarboxylic acid 3-amide 4''-{[3-(5-carbamimidoyl-2-hydroxy-phenyl)-propyl]-amide}


name: 2-(3-Carbamimidoyl-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid methyl-(2'-sulfamoyl-biphenyl-4-yl)-amide TFA


name: (3-Carbamimidoyl-benzoylamino)-phenyl-acetic acid 2-(1-carbamimidoyl-piperidin-4-yl)-ethyl ester


name: 2,6-Bis-(3-carbamimidoyl-phenoxy)-isonicotinic acid ethyl ester


name: 3-[(Biphenyl-4-carbonyl)-amino]-2-(3-carbamimidoyl-benzyl)-5-phenyl-pentanoic acid methyl ester


name: 4-(2-Amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester dihydrochloride


name: Pyrazole-based inhibitor containing N-arylpiperidiny, 16i


name: [3-(3-Carbamimidoyl-phenyl)-5-(4-carbamimidoyl-phenylcarbamoyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid ethyl ester


name: (E)-3-[(Biphenyl-4-carbonyl)-amino]-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enoic acid methyl ester


name: [3-(4-Carbamimidoyl-phenyl)-5-(3-carbamimidoyl-phenylcarbamoyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid methyl ester


name: (E)-2-(3-Carbamimidoyl-benzyl)-3-[(naphthalene-2-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester


name: 1-{4-[4-Chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenylcarbamoyl]-benzyl}-piperidine-4-carboxylic acid ethyl ester


PENTAGALLOYL GLUCOSE

A galloyl-beta-D-glucose compound having five galloyl groups in the 1-, 2-, 3-, 4- and 6-positions.


name: ({4-[4-Chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenylcarbamoyl]-benzyl}-methyl-amino)-acetic acid ethyl ester


name: 2,6-Bis-(3-carbamimidoyl-phenoxy)-nicotinic acid ethyl ester


name: [3-(3-Carbamimidoyl-phenyl)-5-(3'-methyl-biphenyl-4-ylcarbamoyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid methyl ester TFA


name: 4-[4-(2-Amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)piperidin-1-yl]pyridine-3-carboxylic acid methyl ester dihydrochloride


name: 3-(7-Carbamimidoyl-naphthalen-2-yl)-2-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid ethyl ester


name: Acetic acid (E)-3-[(biphenyl-4-carbonyl)-amino]-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enyl ester


name: (2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-acetic acid ethyl ester


name: (E)-3-(4-Benzyl-benzoylamino)-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enoic acid methyl ester


name: 2-[2-(4-Carbamimidoyl-benzenesulfonylamino)-acetylamino]-3-(4-carbamimidoyl-phenyl)-propionic acid ethyl ester


name: 3-[3-Methyl-5-(2''-sulfamoyl-biphenyl-4-ylcarbamoyl)-pyrazol-1-yl]-naphthalene-2-carboxylic acid methyl ester


name: (E)-2-(3-Carbamimidoyl-benzyl)-3-(4-cyclohexyl-benzoylamino)-5-phenyl-pent-4-enoic acid methyl ester


name: (E)-2-(3-Carbamimidoyl-benzyl)-3-(4-methyl-benzoylamino)-5-phenyl-pent-4-enoic acid methyl ester


name: (2-Carbamimidoyl-benzo[b]thiophen-6-yloxy)-acetic acid ethyl ester


name: 3-(3-Carbamimidoyl-phenyl)-2-[2-(4-thiocarbamoyl-benzenesulfonylamino)-acetylamino]-propionic acid ethyl ester


name: (E)-(2R,3R)-3-Benzoylamino-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enoic acid methyl ester


name: (E)-3-Benzoylamino-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enoic acid methyl ester


name: (E)-2-(3-Carbamimidoyl-benzyl)-3-[(naphthalene-1-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester


name: 2-[2-(4-Carbamimidoyl-benzenesulfonylamino)-acetylamino]-3-(3-carbamimidoyl-phenyl)-propionic acid ethyl ester


name: {3-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-phenyl}-acetic acid ethyl ester


name: 3-(5-Carbamimidoyl-benzofuran-2-yl)-2-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid ethyl ester


name: 4-Pyridin-2-ylethynyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester


name: 4-Pyridin-2-ylethynyl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester


name: 4-Pyridin-2-ylethynyl-3,6-dihydro-2H-pyridine-1-carboxylic acid phenyl ester


voxtalisib

A sulfonamide obtained by formal condensation of the sulfonic acid group of 4-[(3-methoxy-4-methylbenzoyl)amino]benzenesulfonic acid with the primary aromatic amino group of N-(3,5-dimethoxyphenyl)quinoxaline-2,3-diamine. A dual PI3K/mTOR inhibitor used in cancer treatment.


name: 4-[5-(2,4-Dioxothiazolidin-5-ylidenemethyl)furan-2-yl]-3-hydroxybenzoic acid methyl ester


name: 3-(3,3-dimethyl-1-oxo-isochroman-4-yl)-3H-imidazole-4-carboxylic acid ethyl ester


thymidine

A pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase.


A prenol phosphate comprising (2E)-4-hydroxy-3-methylbut-2-en-1-ol having an O-diphosphate substituent.


name: 12-Chloro-6,6-dioxo-5,6-dihydro-6lambda*6*-thia-4,5-diaza-chrysene-9-carboxylic acid cyclopentyl ester


guanosine 5'-diphosphate

A  purine ribonucleoside 5'-diphosphate resulting from the formal condensation of the hydroxy group at the 5' position of guanosine with pyrophosphoric acid.


name: Imidazolyl biphenyl sulfonylurea derivative


PHYSALIN F

A physalin with antimalarial and antitumour activities isolated from Physalis angulata.


dolutegravir

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1.


ibogaine

An organic heteropentacyclic compound that is ibogamine in which the indole hydrogen para to the indole nitrogen has been replaced by a methoxy group.


A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2', 3 and 4. The precursor of 3',4'-dihydroxyaurone.


(S)-crizotinib

A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that is the (S)-enantiomer of crizotinib.


A pyrazoloquinoline that is 6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline bearing an additional 2-[(2-hydroxyethoxy)ethyl]amino substituent at position 4


acetyl CoA

An acyl-CoA having acetyl as its S-acetyl component.


coenzyme A

A thiol comprising a panthothenate unit in phosphoric anhydride linkage with a 3',5'-adenosine diphosphate unit; and an aminoethanethiol unit.


name: Sulfamic acid 2-tert-butyl-4-oxo-4H-chromen-6-yl ester


name: Sulfamic acid 2-nonyl-4-oxo-4H-chromen-6-yl ester


name: Sulfamic acid 2-adamantan-2-ylidenemethyl-benzooxazol-6-yl ester


name: Sulfamic acid 2-adamantan-1-yl-4-oxo-4H-thiochromen-6-yl ester


name: Sulfamic acid 2-adamantan-2-yl-4-oxo-4H-chromen-6-yl ester


name: Sulfamic acid 2-tert-butyl-4-oxo-4H-thiochromen-6-yl ester


name: Sulfamic acid 2-adamantan-1-yl-4-oxo-4H-chromen-6-yl ester


name: Sulfamic acid 4-oxo-2-(4-pentyl-bicyclo[2.2.2]oct-1-yl)-4H-chromen-6-yl ester


name: Sulfamic acid 4-oxo-2-(4-pentyl-bicyclo[2.2.2]oct-2-yl)-4H-chromen-6-yl ester


name: 4-(4-Bromo-2,5-dichloro-thiophene-3-sulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester


name: Sulfamic acid 4-oxo-2-(2,2,3,3-tetramethyl-cyclopropyl)-4H-chromen-6-yl ester


name: Sulfamic acid 2-cyclododecyl-4-oxo-4H-chromen-6-yl ester


name: Sulfamic acid 3-cyclohexyl-4-oxo-4H-chromen-7-yl ester


name: Sulfamic acid 2-cyclohexyl-4-oxo-4H-chromen-6-yl ester


name: Sulfamic acid 4-oxo-2-phenyl-4H-thiochromen-6-yl ester


name: Sulfamic acid 2-(1,1-dimethyl-nonyl)-4-oxo-4H-chromen-6-yl ester


name: Sulfamic acid 2-cyclopentyl-4-oxo-4H-chromen-6-yl ester


name: Sulfamic acid 2-adamantan-1-yl-4-oxo-chroman-6-yl ester


name: 4-Sulfamoyloxy-benzoic acid cyclooctyl ester


name: Sulfamic acid 4-oxo-2-phenethyl-4H-chromen-6-yl ester


name: 4-(3,5-Bis-trifluoromethyl-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester


name: Sulfamic acid 2-cyclohexyl-4-oxo-chroman-6-yl ester


name: Sulfamic acid 2-adamantan-1-yl-4-hydroxy-chroman-6-yl ester


name: Sulfamic acid 4-oxo-3-phenyl-4H-chromen-7-yl ester


name: 4-(3,5-Dichloro-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester


name: 4-Sulfamoyloxy-benzoic acid cycloheptyl ester


name: Phenyl-acetic acid (1R,3R,5S)-8-(4-trifluoromethyl-benzenesulfonylaminocarbonyl)-8-aza-bicyclo[3.2.1]oct-3-yl ester


name: Sulfamic acid 4-oxo-2-phenyl-4H-chromen-6-yl ester


name: Sulfamic acid 4-oxo-2-propyl-4H-chromen-6-yl ester


name: Phenyl-acetic acid (1S,3R,5R)-8-(4-chloro-benzenesulfonylaminocarbonyl)-8-aza-bicyclo[3.2.1]oct-3-yl ester


name: Sulfamic acid 5,6,7,8-tetrahydro-naphthalen-2-yl ester


name: (3,4-Dihydro-1H-isoquinolin-2-yl)-carbamic acid 4-tert-butoxycarbonylamino-phenyl ester


name: [4-(Morpholin-4-ylcarbamoyloxy)-phenyl]-acetic acid benzyl ester


name: Morpholin-4-yl-carbamic acid 4-(cyclohexanecarbonyl-amino)-phenyl ester


name: (3,4-Dihydro-1H-isoquinolin-2-yl)-carbamic acid 4-chloro-phenyl ester


name: (4-Methoxy-phenyl)-methyl-carbamic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester


name: Pyrrolidine-1-carboxylic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester


name: Pyrrolidin-1-yl-carbamic acid 4-chloro-phenyl ester


name: (2-Chloro-phenyl)-methyl-carbamic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester


name: 1-(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carbonyl)-piperidine-3-carboxylic acid ethyl ester


name: (1-Methyl-3,4-dihydro-1H-isoquinolin-2-yl)-carbamic acid 4-chloro-phenyl ester


name: (3-Methyl-3,4-dihydro-1H-isoquinolin-2-yl)-carbamic acid 4-chloro-phenyl ester


name: Methyl-o-tolyl-carbamic acid 4-(trifluoromethylpyridin-2-yloxy)-phenyl ester


name: Methyl-phenyl-carbamic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester


name: Methyl-phenyl-carbamic acid 4-(5-chloropyridin-2-yloxy)-phenyl ester


name: Morpholin-4-yl-carbamic acid 4-(3,3-dimethyl-butyrylamino)-phenyl ester


name: Piperidin-1-yl-carbamic acid 4-chloro-phenyl ester


name: (2-Methoxy-phenyl)-methyl-carbamic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester


name: Piperidine-1-carboxylic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester


name: (3-Chloro-phenyl)-methyl-carbamic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester


name: (3,4-Dihydro-1H-isoquinolin-2-yl)-carbamic acid 4-benzyl-phenyl ester


name: 4-Hydroxymethyl-piperidine-1-carboxylic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester


name: 4-Methyl-piperidine-1-carboxylic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester


name: [4-(Morpholin-4-ylcarbamoyloxy)-phenyl]-acetic acid ethyl ester


name: (3,4-Dihydro-1H-isoquinolin-2-yl)-carbamic acid phenyl ester


name: 4-Benzyl-piperidine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester


name: Methyl-m-tolyl-carbamic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester


name: Morpholine-4-carboxylic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester


name: 4-Hydroxy-piperidine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester


name: Methyl-p-tolyl-carbamic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester


name: (3,4-Dihydro-1H-isoquinolin-2-yl)-carbamic acid 4-methoxy-phenyl ester


name: (4-Methyl-piperazin-1-yl)-carbamic acid 4-chloro-phenyl ester


name: Methyl-phenyl-carbamic acid 4-(3,5-dichloro-pyridin-2-yloxy)-phenyl ester


name: 2,6-Dimethyl-morpholine-4-carboxylic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester


name: [4-(Morpholin-4-ylcarbamoyloxy)-phenyl]-acetic acid methyl ester


A sulfonamide that is 5-chloronaphthalene-2-sulfonamide in which one of the hydrogens of the nitrogen atom is substituted by a 4-aminobutyl group.


sulfisoxazole

A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.


name: (S)-2-[3-(2-Fluoro-benzyl)-ureido]-4-methylsulfanyl-butyric acid methyl ester


A quinoline that is 1,2-dihydroquinoline bearing three methyl substituents at position 2, 2 and 4 as well as an ethoxy substituent at position 6.


tolnaftate

A monothiocarbamic ester that is the methyl(3-tolyl)carbamothioate ester of 2-naphthol. A synthetic anti-fungal agent used to treat jock itch, athlete's foot and ringworm.


name: Piperidine-1,4-dicarboxylic acid 1-cyclohexylamide 4-[(5-ethyl-[1,3,4]thiadiazol-2-yl)-amide]


name: Pyrrolidine-1,2-dicarboxylic acid 1-[(3,5-dimethyl-phenyl)-amide] 2-[(3-methyl-4-tetrazol-1-yl-phenyl)-amide]


oxybenzone

A hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively.


name: 5-bromo-2-thiophenecarboxylic acid 1,3-benzothiazol-2-ylmethyl ester


name: 4-[2-(4-Imidazol-1-yl-phenoxy)-ethyl]-piperazine-1-carboxylic acid ethyl ester


name: 3-Nitro-4-(2-oxo-pyrrolidin-1-yl)-benzenesulfonic acid 3-chloro-phenyl ester


name: 7-amino-2-(4-tert-butylphenyl)-6-pyrazolo[1,5-a]pyrimidinecarboxylic acid ethyl ester


name: 3-[(4-phenyl-1-piperazinyl)sulfonyl]benzoic acid [2-(2-furanylmethylamino)-2-oxoethyl] ester


name: 2-(3-formyl-2,5-dimethyl-1-pyrrolyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid methyl ester


name: 2-{2-Methoxy-5-[(E)-[1,2,4]triazol-4-yliminomethyl]-benzyloxy}-benzoic acid ethyl ester


idebenone

A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.


name: 2-[8-bromo-7-[(2-chlorophenyl)methyl]-3-methyl-2,6-dioxo-1-purinyl]acetic acid methyl ester


FLUORESCEIN

A xanthene dye that is highly fluorescent and commonly used as a fluorescent tracer.


(S)-tetrindole

An 8-cyclohexyl-2,3,3a,4,5,6-hexahydropyrazino[3,2,1-jk]carbazole that is the (S)-enantiomer of tetrindole.


name: 3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-propionylamino)-ethoxymethyl]-benzoic acid methyl ester


name: [(S)-1-((S)-1-Benzyl-2-oxo-2-phenethylcarbamoyl-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester


hederagenin 28-O-beta-D-glucopyranoside

A triterpenoid saponin that is the carboxylic ester obtained by the formal condensation of the carboxy group of  hederagenin with beta-D-glucopyranose.  It has been isolated from Juglans sinensis.


A pentacyclic triterpenoid that is the C-4 epimer of hederagenin. It has been isolated from the roots of Rubia yunnanensis.


TETRAHYDROBERBERINE

A berberine alkaloid that is 5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline substituted by methoxy groups at positions 9 and 10.


TETRAHYDROPALMATINE

A berberine alkaloid obtained by formal addition of two molecules of hydrogen to the pyridine ring of palmatine.


mepacrine

A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.


name: (2-Isopropyl-quinazolin-4-ylsulfanyl)-acetic acid methyl ester


name: Alpha-ketocarbonyl boronic ester derivative


name: 3-(4-[4-Chloro-2-(2-methyl-pyridine-3-carbonyl)-phenylsulfamoyl]-phenyl)-propionic acid methyl ester


name: 3-{4-[4-Chloro-2-(6-methyl-pyridine-3-carbonyl)-phenylsulfamoyl]-phenyl}-propionic acid methyl ester


CYCLOPENTANONE

A cyclic ketone that consists of cyclopentane bearing a single oxo substituent.


pyridoxal hydrochloride

A hydrochloride obtained by combining pyridoxal with one molar equivalent of hydrochloric acid.


SALICYLADEHYDE

A hydroxybenzaldehyde carrying a hydroxy substituent at position 2.


vanillin

A member of the class of benzaldehydes carrying methoxy and hydroxy substituents at positions 3 and 4 respectively.


QUINOLINIC ACID

A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.


A dipeptide resulting from the formal coupling of the carboxy group of N(2)-(diphenylacetyl)-D-arginine with the alpha-amino group of D-2-phenylglycinamide.


name: (S)-2-{(S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-propionylamino}-3-phenyl-propionic acid tert-butyl ester


A peptide and carboxamide that is L-leucyl-L-phenylalaninamide, L-Leu-L-Phe-NH2, which has been acylated on the N-terminus by a Phe-Phe hydroxyethylene dipeptide isotere,  2R-benzyl-5S-tert-butoxycarbonylamino-4R-hydroxy-6-phenylhexanoic acid. Compounds based on the structure of L-685,458 are potent inhibitors of gamma-secretase, which mediates the final catalytic step that generates the amyloid beta-peptide (Abeta), which assembles into the neurotoxic aggregates in the brains of sufferers of Alzheimer's disease.


name: 3-[(Z)-5,6,7,8-tetrahydro-naphthalen-1-ylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrazole-3-carboxylic acid with the amino group of (1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-amine. A potent and selective cannabinoid receptor type 2 (CB2 receptor) inverse agonist (Ki = 0.6 nM).


name: 3-[(Z)-2-isopropyl-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-[(Z)-benzo[1,2,5]oxadiazol-4-ylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-[(Z)-2,3-dimethyl-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-[(Z)-3-methoxy-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 8-[(Z)-2-isopropyl-phenylimino]-7-thia-9-aza-spiro[4.5]decane-9-carbodithioic acid methyl ester


name: 3-[(Z)-1-methyl-1,2,3,4-tetrahydro-quinolin-5-ylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-[(Z)-2-trifluoromethyl-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-[(Z)-2-methoxy-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-[(Z)-4-ethyl-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-[(Z)-benzo[1,2,5]thiadiazol-4-ylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-[(Z)-4-cyano-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-[(Z)-3-isopropyl-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-(1,1-Dimethyl-heptyl)-1-hydroxy-6,6-dimethyl-6H-benzo[c]chromene-9-carboxylic acid methyl ester


name: 3-[(Z)-4-methoxy-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 1-Butanesulfonic acid, 4,4,4-trifluoro-, 3-(((2R)-2,3-dihydro-2-(hydroxymethyl)-1H-inden-4-yl)oxy)phenyl ester


name: 3-[(Z)-indan-4-ylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-[(Z)-naphthalen-1-ylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-[(Z)-4-trifluoromethoxy-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-[(Z)-2-ethoxy-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-Pentyl-4-phenyl-4,5-dihydro-pyraz ole-1-carboxylic acid adamantan-2-y lamide


name: 3-[(Z)-4-propyl-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: (S)-2-{[7-Methoxy-2-methyl-1-(2-morpholin-4-yl-ethyl)-1H-indole-3-carbonyl]-amino}-3-phenyl-propionic acid methyl ester


name: 4-Quinolone-3-Carboxamide Furan CB2 Agonist


name: 3-[(Z)-quinolin-5-ylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


A carbobicyclic compound that is bicyclo[3.1.1]hept-2-ene which is substituted by a hydroxymethyl group at position 2, a 2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl group at position 4, and two methyl groups at position 6 (the 1S,4S,5S stereoisomer). A highly selective and effective cannabinoid type-2 agonist and the enantiomer of HU-433.


name: 3-[(Z)-2-trifluoromethoxy-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-Pentyl-4-phenyl-4,5-dihydro-pyraz ole-1-carboxylic acid adamantan-1-y lamide


name: 3-[(Z)-4-trifluoromethyl-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-[(Z)-4-isopropyl-phenylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 3-[(Z)-5,6,7,8-tetrahydro-naphthalen-2-ylimino]-2-thia-4-aza-spiro[5.5]undecane-4-carbodithioic acid methyl ester


name: 2-(3-Chlorophenylamino)-4-trifluoromethylpyridine-5-carboxylic acid cyclohexylmethyl amide


name: 3-Pentyl-4-phenyl-4,5-dihydro-pyrazole-1-carboxylic acid cyclohexylmet hyl-amide


Δ9-Tetrahydrocannabinolic acid

A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. A biosynthetic precursor to Delta(9)-tetrahydrocannabinol, the principal psychoactive constituent of the cannabis plant.


name: 6-[(Z)-2-isopropyl-phenylimino]-5-thia-7-aza-spiro[2.5]octane-7-carbodithioic acid methyl ester


name: (S)-2-[(E)-3-(4-Methoxy-3-pentyloxy-phenyl)-acryloylamino]-3-phenyl-propionic acid methyl ester


A pyrrolidin-2-one substituted by 6-carboxyhexyl and 3-hydroxyoctyl groups at positions 1 and 2, respectively. It is a potent prostaglandin EP4 receptor agonist (Ki=35 nM).


name: Acetic acid 4-[4-(4-methanesulfonyl-phenyl)-2-oxo-2,5-dihydro-furan-3-yl]-phenyl ester


name: Acetic acid 3-[4-(4-methanesulfonyl-phenyl)-2-oxo-2,5-dihydro-furan-3-yl]-phenyl ester


name: Acetic acid 2-[4-(4-methanesulfonyl-phenyl)-2-oxo-2,5-dihydro-furan-3-yl]-phenyl ester


CIMICOXIB

An imidazole substituted at positions 1, 4 and 5 by 4-aminosulfonylphenyl, chloro and 3-fluoro-4-methyoxyphenyl groups respectively. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in dogs.


MAVACOXIB

A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and 4-fluorophenyl groups, respectively. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine to treat pain and inflammation in dogs with degenerative joint disease.


name: [1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-tert-butoxycarbonylamino-ethyl ester


deracoxib

A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3, and 5 by 4-sulfamoylphenyl, difluoromethyl and 3-fluoro-4-methoxyphenyl groups, respectively. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in dogs.


A member of the class of  pyrazoles that is 1H-pyrazole substituted by a 4-fluorophenyl group at position 5, a 4-(methylsulfonyl)phenyl group at position 1 and a trifluoromethyl group at position 3. A selective cyclooxygenase 2 inhibitor, it exhibits anticancer property.


name: [1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid pentyl ester


name: [1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid hept-2-enyl ester


name: [1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid butyl ester


name: (4-{2-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetylamino}-phenyl)-acetic acid methyl ester


name: [1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid hexyl ester


name: [1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-butoxy-ethyl ester


TILMACOXIB

A member of the class of 1,3-oxazoles that is that is 1,3-oxazole which is substituted at positions 2, 4 and 5 by methyl, cyclohexyl, and 3-fluoro-4-sulfamoylphenyl groups, respectively.


name: [1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid propyl ester


name: [1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid cyclohexyl ester


name: [1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 1-methyl-hex-3-ynyl ester


KETOROLAC TROMETHAMINE

An organoammonium salt resulting from the mixture of equimolar amounts of ketorolac and tromethamine (tris). It has potent non-sedating analgesic and moderate anti-inflammatory effects. It is used in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.


firocoxib

An enol ether that is the cyclopropylmethyl ether of 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2-one. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in horses and dogs.


name: [1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid hept-2-ynyl ester


name: BENZOIC ACID, p-CHLORO-, 2-(p-CHLOROPHENYL)HYDRAZIDE


name: 3-(2,4-Difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid methyl ester


name: [1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid phenyl ester


name: Acetic acid 1-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-2-methyl-1H-pyrrol-3-ylmethyl ester


name: 4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-thiazole-2-carboxylic acid ethyl ester


An indolyl carboxylate ester that is methyl 1H-indole-2-carboxylate substituted by a 4-chlorobenzyl group at position 1 and a methylsulfonyl group at position 5. It acts as a selective inhibitor of cyclooxygenase 2.


name: [1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-morpholin-4-yl-ethyl ester


name: 1-(4-Chloro-benzoyl)-5-methanesulfonyl-1H-indole-2-carboxylic acid methyl ester


name: 5-Methanesulfonyl-1-(4-methoxy-benzyl)-1H-indole-2-carboxylic acid methyl ester


name: 3-(4-Fluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid methyl ester


name: 5-(4-Methanesulfonyl-phenyl)-6-phenyl-imidazo[2,1-b]thiazole-3-carboxylic acid ethyl ester


name: [1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-cyclohexyl-ethyl ester


name: Bromo-acetic acid 3-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclopentyl ester


name: Bromo-acetic acid 2-(8-cyclopentyl-2,6-dioxo-1-propyl-1,2,6,7-tetrahydro-purin-3-yl)-1-methyl-ethyl ester


name: 3-Fluorosulfonyl-benzoic acid 3-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclopentyl ester


name: Bromo-acetic acid 3-(8-cyclopentyl-2,6-dioxo-1-propyl-octahydro-purin-3-yl)-propyl ester


name: 4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester


name: 1-(2-chloro-2-phenyl-ethyl)-4-(2-p-tolyl-ethylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester


name: 3-Fluorosulfonyl-benzoic acid 3-(8-cyclopentyl-2,6-dioxo-1-propyl-1,2,6,7-tetrahydro-purin-3-yl)-propyl ester


name: 1-(2-chloro-2-phenyl-ethyl)-4-(2-p-tolyl-ethylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester


name: 1-(2-chloro-2-phenyl-ethyl)-4-(2-p-tolyl-ethylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid isopropyl ester


name: 4-Fluorosulfonyl-benzoic acid 3-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-cyclopentyl ester


name: 4-Fluorosulfonyl-benzoic acid 3-(8-cyclopentyl-2,6-dioxo-3-propyl-2,3,6,7-tetrahydro-purin-1-yl)-propyl ester


name: 1-Propanesulfonic acid, 3,3,3-trifluoro-, 4-(2-(2,4-dichlorophenyl)-5-methyl-4-((1-piperidinylamino)carbonyl)-1H-imidazol-1-yl)phenyl ester


name: Butane-1-sulfonic acid 4-[2-(2,4-dichlorophenyl)-5-methyl-4-(piperidin-1-ylcarbamoyl)-imidazol-1-yl]phenyl ester


name: Propane-1-sulfonic acid 4-[2-(2,4-dichlorophenyl)-5-methyl-4-(piperidin-1-ylcarbamoyl)-imidazol-1-yl]phenyl ester


name: 2-Butoxy-5-(4-chloro-phenyl)-6-(2,4-dichloro-phenyl)-nicotinic acid methyl ester


name: 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-5-methyl-1H-imidazole-4-carboxylic acid tert-butyl ester


name: 5-(4-Chloro-phenyl)-2-cyclohexylmethoxy-6-(2,4-dichloro-phenyl)-nicotinic acid methyl ester


name: 4-Methyl-3-(morpholine-4-sulfonyl)-benzoic acid 2-methoxy-phenyl ester


name: 1-Benzyl-2-imino-10-oxo-1,10-dihydro-2H-1,9,10a-triaza-anthracene-3-carboxylic acid ethyl ester


name: 11-Cyclohexyl-dibenzo[b,f] [1,4]oxazepine-8-carboxylic acid piperidin-1-ylamide


name: 1-(2,2-Diphenyl-ethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid methyl ester


name: {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyryl]-amino}-acetic acid methyl ester


CANGRELOR TETRASODIUM

An organic sodium salt that is the tetrasodium salt of cangrelor. Used as an intravenous antiplatelet drug that prevents formation of harmful blood clots in the coronary arteries.


LEUKOTRIEN E4

A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and an L-cystein-S-yl group at position 6 (6R).


name: 4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid isopropyl ester


name: {Cyclohexyl-[4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyryl]-amino}-acetic acid ethyl ester


name: 4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid ethyl ester


name: 1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyryl]-piperidine-4-carboxylic acid ethyl ester


name: 6-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-hexanoic acid methyl ester


CGP 78608

A phosphonic acid in which the hydrogen attached to phosphorous is substituted by a 1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl group. Potent and selective NMDA antagonist that acts through the glycine site (IC50 = 5 nM). Displays >500-fold selectivity over kainate and AMPA receptors (IC50 values are 2.7 and 3 muM respectively). Anticonvulsant in vivo following systemic administration.


name: {4-[1''-(Naphthalene-1-carbonyl)-[1,4'']bipiperidinyl-4-ylmethyl]-phenylsulfanyl}-acetic acid methyl ester


name: 1-Ethyl-4-phenyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid decyl ester


name: 2-(4-Methylcarbamoyloxy-phenyl)-2-phenyl-propionic acid 2-diethylamino-ethyl ester


name: 2-(4-Dimethylcarbamoyloxy-phenyl)-2-phenyl-propionic acid 2-diethylamino-ethyl ester


name: exo-8-Benzyloxymethyl-4-hydroxy-1-aza-bicyclo[3.3.1]non-3-ene-3-carboxylic acid ethyl ester


name: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER


pyridoxal 5-phosphate

The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.


An oxysterol that is cholesterol which is substituted by hydroxy groups at the 7alpha and 26 positions.


name: 2-Aminobenzimidazole with trans-stilbene, 8c


name: 2-Aminobenzimidazole with trans-stilbene, 8a


name: 2-Aminobenzimidazole with trans-stilbene, 8g


name: 2-Aminobenzimidazole with trans-stilbene, 8n


name: 2-Aminobenzimidazole with trans-stilbene, 8q


name: 2-Aminobenzimidazole with trans-stilbene, 8b


name: 2-Aminobenzimidazole with trans-stilbene, 8w


name: 2-Aminobenzimidazole with trans-stilbene, 8t


name: 2-Aminobenzimidazole with trans-stilbene, 8p


name: 2-Aminobenzimidazole with trans-stilbene, 8s


name: 2-Aminobenzimidazole with trans-stilbene, 8v


name: 2-Aminobenzimidazole with trans-stilbene, 8e


name: 2-Aminobenzimidazole with trans-stilbene, 8f


name: 2-Aminobenzimidazole with trans-stilbene, 8u


name: 2-Aminobenzimidazole with trans-stilbene, 8i


name: Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)


name: (2S,3S)-2-Amino-3-((3-phenyl-1-tosyl-1H-indol-6-yl)methoxy)succinic acid trifluoroacetic acid


tyrphostin AG 825

An organic sulfide that consists of  1,3-benzothiazole-2-thiol in which the hydrogen attached to the sulfur atom is replaced by a 5-[(1E)-3-amino-2-cyano-3-oxoprop-1-en-1-yl]-2-hydroxy-3-methoxybenzyl group. It acts as an  epidermal growth factor receptor antagonist.


IPAG

IPAG is a potent sigma-receptor antagonist.


DEGUELIN

A rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers.


name: 2-Propanol, 1-(cyclohexylamino)-, 2-benzoate, (S)-


(R)-canadine

A canadine which has R configuration.


name: [5-Benzyl-4-(3-chloro-phenyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid ethyl ester


GRAMINE

An aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3.


(R)-idazoxan

An idazoxan that has R configuration.


name: 2-Benzyloxycarbonylamino-3-methyl-pentanoic acid 1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl ester


name: (-)-cis-(1S,2R)-u-50488 Tartrate potent sigma ligand


RS 39604

An aromatic ether that is the 3,5-dimethoxybenzyl derivative of N-(2-{4-[3-(4-amino-5-chloro-2-hydroxyphenyl)-3-oxopropyl]piperidin-1-yl}ethyl)methanesulfonamide. A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and alpha1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.


GENTIAN VIOLET

An organic chloride salt that is the monochloride salt of crystal violet cation. It has been used in creams for the topical treatment of bacterial and fungal infections, being effective against some Gram-positive bacteria (notably Staphylococcus species) and some pathogenic fungi (including Candida species) but use declined following reports of animal carcinogenicity. It has also been used for dying wood, silk, and paper, as well as a histological stain.


PAROXETINE HYDROCHLORIDE

The hydrochloride salt of paroxetine. It is an antidepressant drug.


ALVERINE CITRATE

The citrate salt of alverine, resulting from the reaction of equimolar amounts of alvarine and citric acid. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used in the treatment of irritable bowel syndrome.


name: 5-bromo-3-[[2-(4-cyclohexyl-1-piperazinyl)-1-oxoethyl]amino]-1H-indole-2-carboxylic acid methyl ester


A myo-inositol tetrakisphosphate having the four phosphates placed in the 1-, 3-, 4- and 5-positions.


name: Phosphoric acid mono-((1R,2S,3R,4S,5S,6R)-2,3,4-trihydroxy-5,6-bis-phosphonooxy-cyclohexyl) ester


A myo-inositol tetrakisphosphate having the four phosphate groups at the 1-, 4-, 5- and 6-positions.


A myo-inositol tetrakisphosphate having the four phosphate groups placed at the 3-, 4-, 5- and 6-positions.


A member of the class of benzaldehydes carrying a diethylamino substituent at position 4.


REVERSINE

A member of the class of purines that is 9H-purine in which the hydrogens at positions 2 and 6 are replaced by a [4-(morpholin-4-yl)phenyl]nitrilo group and a cyclohexylamino group, respectively.


ZINC CHLORIDE

A compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.


EMODIN

A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.


The hydrochloride salt of 3',4'-difluoro-N-{4'-fluoro-6-[(3S)-pyrrolidin-3-yloxy][biphenyl]-3-yl}-6-[(3S)-pyrrolidin-3-yloxy][biphenyl]-3-carboxamide. It is a beta-catenin/BCL9 protein-protein interaction inhibitor (Ki = 2.1 muM).


beta-catenin - TCF interaction inhibitor


QUINALIZARIN

A tetrahydroxyanthraquinone having the four hydroxy groups at the 1-, 2-, 5- and 8-positions.


OXIDOPAMINE

A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).


GOSSYPETIN

A hexahydroxyflavone having the hydroxy groups placed at the 3-, 3'-, 4'-, 5- 7- and 8-positions.


name: N-[4-(1,3-benzothiazol-2-yl)phenyl]-N-methylcarbamic acid tert-butyl ester


GSK503 is a potent and specific inhibitor of EZH2 methyltransferase.


A qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals.


gentian violet

An iminium ion that is malachite green cation in which the hydrogen at the para- psition of the monosubstituted phenyl group is replaced by a dimethylamino group.


(+)-menthofuran

A menthofuran that is 4,5,6,7-tetrahydro-1-benzofuran substituted by methyl groups at positions 3 and 6 (the 6R-enantiomer).


HOMIDIUM BROMIDE

The organic bromide salt of ethidium.


An N-acylpiperazine that is piperazine substituted by 5-methyl-4-nitro-1,2-oxazole-3-carbonyl and bis(4-chlorophenyl)methyl groups at positions 1 and 4, respectively. It is a glutathione peroxidase 4 (GPX4) inhibitor which induces ferroptosis in cancer cells expressing the RAS oncogene.


A 1-acyl-sn-glycerophosphoserine compound having an oleoyl substituent at the 1-hydroxy position.


atglistatin

A biphenyl that is 1,1'-biphenyl substituted by (dimethylcarbamoyl)amino and dimethylamino groups at positions 3 and 4', respectively. It is a potent inhibitor of adipose triglyceride lipase activity (IC50 = 700nM).


phenylpyruvic acid oxime

A ketoxime obtained by condensation of the keto group of phenylpyruvic acid with hydroxylamine.


example 15 [WO2015079413]

A flavanone glycoside that is eriodictyol attached to a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage. It is an Nrf2 activator and provides protection against cisplatin-induced toxicity.


pyrvinium

A quinolinium ion that is 1-methylquinolinium substituted by dimethylamino group at position 6 and a (E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl at position 2. It is a  anthelminthic drug active against pinworms. The salts of pyrvinium can also be used as anticancer agents.


PYRAZINOIC ACID

The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide.


ISONICOTINIC ACID

A pyridinemonocarboxylic acid in which the carboxy group is at position 4 of the pyridine ring.


PYRIDINE

An  azaarene comprising a benzene core in which one -CH group is replaced by a nitrogen atom. It is the parent compound of the class pyridines.


2-aminonicotinic acid

An aminonicotinic acid in which the amino group is situated at position 2 of the pyridine ring.


aminophenazone

A  pyrazolone  that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.


acetanilide

A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a phenyl group.


2-PICOLINIC ACID

A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.


benzoic acid

A compound comprising a benzene ring core carrying a carboxylic acid substituent.


A cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'- and 2',5'-linkages respectively.


c-GMP-AMP

A cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'-linkages.


HISTIDINOL

An amino alcohol that is propanol substituted by 1H-imidazol-4-yl group at position 3 and an amino group at position 2 (the 2S stereoisomer).


ACETYLGLUTAMIC ACID

An N-acyl-L-amino acid that is L-glutamic acid in which one of the amine hydrogens is substituted by an acetyl group.


PELARGONIDIN CHLORIDE

An anthocyanidin chloride that has pelargonidin as the cationic counterpart.


EPITESTOSTERONE

An androstanoid that is the C-17 epimer of testosterone.


The 5alpha-stereoisomer of androstane-3,17-dione.


L-glyceric acid

An optically active form of glyceric acid having L-configuration.


The simplest member of the class of pyrrolidin-2-ones, consisting of pyrrolidine in which the hydrogens at position 2 are replaced by an oxo group. The lactam arising by the formal intramolecular condensation of the amino and carboxy groups of gamma-aminobutyric acid (GABA).


urea

A carbonyl group with two C-bound amine groups. The commercially available fertilizer has an analysis of 46-0-0 (N-P2O5-K2O).


3-hydroxypyruvic acid

A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a hydroxy group. It is an intermediate involved in the glycine and serine metabolism.


TETRAHYDROCURCUMIN

A beta-diketone that is curcumin in which both of the double bonds have been reduced to single bonds.


cholesterol sulphate

A steroid sulfate that is cholesterol substituted by a sulfoxy group at position 3.


efavirenz

1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.


Obstructive Ureterocele

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A ureterocele with a small, obstructive orifice.


ureterocele

description: A cystic and dysplastic dilation of the distal ureter within the bladder that may extend into the bladder neck and urethra.


Orthotopic ureterocele

description: A ureterocele that is located entirely within the bladder, and which may be associated with a single system, with the upper pole ureter of a completely duplicated system, or rarely associated with a lower pole ureter. (Adapted from Glassberg KI, Braren V, Duckett JW, Jacobs EC, King LR, Lebowitz RL et al. Suggested terminology for duplex systems, ectopic ureters and ureteroceles. J Urol 1984; 132(6):1153-1154.)


Sphincteric Ureterocele

description: A ureterocele in which the orifice is distal to the external urinary sphincter.


Cecoureterocele

description: A ureterocele in which the orifice is located in the bladder, with the ureterocele pouch extending submucosally into the urethra.


Ectopic ureterocele

description: A ureterocele in which some portion of the ureterocele is situated permanently at the bladder neck or in the urethra. The orifice may be situated in the bladder, at the bladder neck, or in the urethra. (Adapted from Glassberg KI, Braren V, Duckett JW, Jacobs EC, King LR, Lebowitz RL et al. Suggested terminology for duplex systems, ectopic ureters and ureteroceles. J Urol 1984; 132(6):1153-1154.)


taurodontism

description: Taurodontism is a dental anomaly characterized by an elongated pulp chamber, displaced toward the apical floor of the tooth with no constriction at the level of the cemento-enamel junction, and short roots. It most frequently affects permanent molar teeth. Taurodontism increases the risk of pulp exposure. It can be isolated or associated with certain syndromes such as Down syndrome, amelogenesis imperfecta, and Klinefelter syndrome.


name: myasthenic syndrome, congenital, 23, presynaptic


name: nephrolithiasis susceptibility caused by SLC26A1


Postsurgical Stage II Hepatoblastoma

description: No metastases, tumor grossly resected with microscopic residual disease (i.e., positive margins); or tumor rupture, or tumor spill at the time of surgery. (from PDQ 2004)


primary ciliary dyskinesia 4

description: A primary ciliary dyskinesia that is characterized by partial absence of the inner dynein arms with variable occurrence of situs inversus and has material basis in variation in the chromosome region 15q13.1-q15.1.


infantile diarrhea

description: Diarrhea occurring in infants from newborn to 24-months old.


name: Premature birth following premature rupture of fetal membranes

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


Premature rupture of membranes

description: Premature rupture of membranes (PROM) is a condition which occurs in pregnancy when the amniotic sac ruptures more than an hour before the onset of labor.


Preterm premature rupture of membranes

description: PPROM (preterm premature rupture of membranes) occurs at less than 37 weeks of gestation. PPROM can happen spontaneously, during preterm labor, or following a procedure such as amniocentesis.


name: Elevated circulating 4-methyl-2-oxopentanoic acid concentration

description: The concentration of 4-methyl-2-oxopentanoic acid in the blood circulation is above the upper limit of normal.


name: structural congenital heart disease, multiple types - GATA4

description: Any congenital heart disease in which the cause of the disease is a mutation in the GATA4 gene.


reactive arthritis

description: Reactive arthritis (ReA) is an autoimmune disorder belonging to the group of seronegative spondyloarthropathies and is characterized by the classic triad of arthritis, urethritis and conjunctivitis.


Localized Parathyroid Gland Carcinoma

description: A parathyroid gland carcinoma that has not spread to other anatomic sites.


name: Nasopharyngeal Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of nasopharyngeal carcinoma according to the American Joint Committee on Cancer, 7th edition.


name: Refractory Thyroid Gland Oncocytic Carcinoma

description: Thyroid gland oncocytic carcinoma that is resistant to treatment.


name: Stage II Differentiated Thyroid Gland Carcinoma AJCC v7

description: Stage II includes: Under 45 years: Any T, Any N, M1.  45 years and older: T2, N0, M0.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland.  N0: No regional lymph node metastasis.  M1: Distant metastasis.  M0: No evidence of distant metastasis.  (from AJCC 7th Ed.)


name: Oropharyngeal (p16-Negative) Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of p16-negative oropharyngeal carcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Thyroid Gland Sclerosing Mucoepidermoid Carcinoma with Eosinophilia

description: A rare type of mucoepidermoid carcinoma of the thyroid gland, usually associated with chronic lymphocytic thyroiditis.  It exhibits a unique morphologic appearance consisting of a squamoid, nested growth pattern, dense fibrosis, and mucinous differentiation.  The histogenesis of this unusual carcinoma has been debated, and it is unclear if it arises from remnants of the ultimobranchial body or from the follicular epithelial cells.


name: Stage I Thyroid Gland Follicular Carcinoma AJCC v8

description: Stage I includes: Under 55 years: Any T, Any N, M0. 55 years and older: (T1, N0/NX, M0); (T2, N0/NX, M0).  T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. N0: No evidence of locoregional lymph node metastasis. NX: Regional lymph nodes cannot be assessed. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Unresectable Laryngeal Squamous Cell Carcinoma

description: Laryngeal squamous cell carcinoma that is not amenable to surgical resection.


name: Metastatic Nasopharyngeal Nonkeratinizing Carcinoma

description: Nasopharyngeal non-keratinizing carcinoma that has spread from its original site of growth to another anatomic site.


Stage IVC Laryngeal Cancer AJCC v8

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Hypopharyngeal Spindle Cell Squamous Carcinoma

description: A squamous cell carcinoma that arises from the hypopharynx. It is characterized by the presence of a malignant spindle cell cellular component. In some cases, there is a biphasic morphology due to the presence of a well-differentiated squamous cell carcinoma component. The latter is either in situ or invasive squamous cell carcinoma.


name: Metastatic Thyroid Gland Anaplastic Carcinoma

description: Thyroid gland anaplastic carcinoma that has spread from the original site of growth to another anatomic site.


name: Hypopharyngeal squamous cell carcinoma stage III

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor measuring more than 4 cm in greatest dimension or with fixation of hemilarynx or extension to esophagus.  T1: Tumor limited to one subsite of hypopharynx and/or 2 cm or less in greatest dimension.  T2: Tumor invades more than one subsite of the hypopharynx or an adjacent site, or measures more than 2 cm but not more than 4 cm in greatest diameter without fixation of hemilarynx.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Oropharyngeal Human Papillomavirus-Related Non-Keratinizing Squamous Cell Carcinoma

description: An oropharyngeal human papillomavirus-related squamous cell carcinoma characterized by the absence of keratinization and intercellular bridges.


name: Stage I Hypopharyngeal Carcinoma AJCC v6

description: Stage I includes: T1, N0, M0.  T1: Tumor limited to one subsite of the hypopharynx and 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.)


name: Spindle Cell Variant Thyroid Gland Papillary Carcinoma

description: Papillary carcinoma of the thyroid gland with focal areas of spindle cell metaplasia.


Locally Advanced Laryngeal Carcinoma

description: Laryngeal carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Carcinoma of pyriform fossa

description: A carcinoma that arises from the pyriform sinus.  Patients usually present with advanced stage disease and the prognosis is poor.


name: Refractory Differentiated Thyroid Gland Carcinoma

description: Differentiated thyroid gland carcinoma that is resistant to treatment.


Stage I Laryngeal Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: (Supraglottis) Tumor limited to one subsite of supraglottis with normal vocal cord mobility. (Glottis) Tumor limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility.  (Subglottis) Tumor limited to the subglottis.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Laryngeal Cancer by AJCC v8 Stage

description: A term that refers to the staging of laryngeal carcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

description: Stage I includes: (T0, N0, M0); (T0, N1, M0); (T1, N0, M0); (T1, N1, M0); (T2, N0, M0); (T2, N1, M0). T0: No primary identified. T1: Tumor 2 cm or smaller in greatest dimension. T2: Tumor larger than 2 cm but not larger than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Tumor with metastasis in four or fewer lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8

description: Stage IVB includes: T4b, Any N, M0. T4b: Very advanced disease; tumor of any size with extension towards the spine or into nearby large blood vessels, invading the prevertebral fascia, or encasing the carotid artery or mediastinal vessels. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Stage IVC Laryngeal Verrucous Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 7th ed.)


name: Thyroid Gland Papillary Carcinoma with Fibromatosis/Fasciitis-Like/Desmoid-Type Stroma

description: A rare morphologic variant of papillary thyroid gland carcinoma characterized by the presence of abundant and cellular stroma resembling nodular fasciitis, fibromatosis, or other proliferative myofibroblastic processes. (WHO)


name: Stage I Thyroid Gland Follicular Carcinoma Under 55 Years AJCC v8

description: Stage I includes: Any T, Any N, M0. M0: No distant metastasis. (from AJCC 8th Ed.)


Stage II Laryngeal Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Supraglottis: Tumor invades the mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (e.g., mucosa of base of the tongue, vallecula, medial wall of pyriform sinus) without fixation of the larynx. Glottis: Tumor extends to supraglottis and/or subglottis, and/or with impaired vocal cord mobility. Subglottis: Tumor extends to vocal cord(s) with normal or impaired mobility. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)