Stage III Colon Cancer AJCC v7

description: Stage III includes: IIIA (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  N1: Metastasis in 1-3 regional lymph nodes.  N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2: Metastasis in four or more regional lymph nodes.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Duodenal carcinoma recurrent

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: The reemergence of duodenal carcinoma after a period of remission.


Ileal Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the ileum. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


name: Transverse Colon Neuroendocrine Tumor G1

description: A well differentiated, low grade neuroendocrine neoplasm that arises from the transverse colon. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Stage IIIC Colorectal Cancer AJCC v7

description: Stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0).  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N1: Metastasis in 1-3 regional lymph nodes.  N2: Metastasis in four or more regional lymph nodes.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Small Intestinal Angiosarcoma

description: An angiosarcoma that arises from the small intestine.


Stage IVA Rectal Cancer AJCC v7

description: Stage IVA includes: Any T, Any N, M1a. M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node). (AJCC 7th ed.)


Stage IIC Rectal Cancer AJCC v8

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Locally Advanced Colorectal Adenocarcinoma

description: Colorectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


description: A rare, invasive colorectal adenocarcinoma characterized by the presence of clusters of malignant glandular cells within stromal spaces.


Secondary malignant neoplasm of rectum

description: The spread of a malignant neoplasm to the rectum.  This may be from a primary large intestine malignant neoplasm, or from a malignant neoplasm at a distant site.


Stage IIB Colon Cancer AJCC v7

description: Stage IIB includes: T4a, N0, M0. T4a: Tumor penetrates to the surface of the visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage I Duodenal Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invading the mucosa or submucosa only and is equal or less than 1 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Rectosigmoid Adenocarcinoma

description: An adenocarcinoma arising from the rectosigmoid area.  It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease.  Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits.  According to the degree of cellular differentiation, rectosigmoid adenocarcinomas are divided into well, moderately, and poorly differentiated.  Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.


Metastatic Colorectal Carcinoma

description: A carcinoma that arises from the colon or rectum and has metastasized to another anatomic site.


Stage IV Rectal Cancer AJCC v6

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th ed.)


name: Stage I Small Intestinal Gastrointestinal Stromal Tumor

description: Stage I includes: T1 or T2, N0, M0, Mitotic rate: Low.  T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm, but not more than 5 cm, in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Advanced Colon Carcinoma

description: Colon carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage III Rectal Cancer AJCC v8

description: Stage III includes: IIIA: (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IIIB Small Intestinal Gastrointestinal Stromal Tumor

description: Stage IIIB includes: (T2, N0, M0, Mitotic rate: High); (T3, N0, M0, Mitotic rate: High); (T4, N0, M0, Mitotic rate: High).  T2: Tumor more than 2 cm, but not more than 5 cm, in greatest dimension. T3: Tumor more than 5 cm, but not more than 10 cm, in greatest dimension. T4: Tumor more than 10 cm in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Colon Cancer by AJCC v6 Stage

description: A term that refers to the staging of colon carcinoma according to the American Joint Committee on Cancer, 6th edition.


Small intestine carcinoma recurrent

description: The reemergence of small intestine carcinoma after a period of remission.


name: Rectal Cribriform Comedo-Type Adenocarcinoma

description: A rare, invasive rectal adenocarcinoma characterized by the presence of malignant cribriform glands with central necrotic changes.


name: Stage IIIB Small Intestinal Cancer AJCC v7

description: Stage IIIB includes: Any T, N2, M0. N2: Metastasis in four or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Meckel Diverticulum Neuroendocrine Tumor G1

description: A well differentiated, low grade neuroendocrine neoplasm that arises in a Meckel diverticulum.


Stage IV Rectal Cancer AJCC v8

description: Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b); IVC: (Any T, Any N, M1c). M1a: Metastasis to one site or organ without peritoneal metastasis. M1b: Metastasis to two or more sites or organs without peritoneal metastasis. M1c: Metastasis to the peritoneal surface alone or with other site or organ metastases. (AJCC 8th ed.)


Colon Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the colon. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Colorectal Adenoma with Mild Dysplasia

description: An adenoma that arises from the colon or rectum.  It is characterized by the presence of mild epithelial dysplasia.


Stage IIC Colorectal Cancer AJCC v8

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Colorectal Low Grade Intraepithelial Neoplasia

description: A precancerous neoplastic process that affects the colon or rectum.  It is characterized by mild epithelial dysplasia and mild architectural alterations of the mucosal epithelium.  There is no evidence of invasion.


name: Refractory Rectal Squamous Cell Carcinoma

description: Rectal squamous cell carcinoma that is resistant to treatment.


Grade 3 Colorectal Adenocarcinoma

description: A colorectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with less than 50% glandular formation.


name: Stage II Ileal Neuroendocrine Tumor AJCC v8

description: Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor invading muscularis propria or measuring more than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Metastatic Microsatellite Stable Colorectal Carcinoma

description: A microsatellite stable carcinoma that arises from the colon or rectum and has metastasized to other anatomic sites.


Stage 0 Colorectal Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ, intramucosal carcinoma (involvement of lamina propria with no extension through muscularis mucosae). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIC Colorectal Cancer AJCC v7

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Locally Advanced Colon Carcinoma

description: Colon carcinoma that has spread to nearby tissues or lymph nodes.


Stage IVA Colorectal Cancer AJCC v8

description: Stage IVA includes: Any T, Any N, M1a. M1a: Metastasis to one site or organ without peritoneal metastasis. (AJCC 8th ed.)


name: Stage IV Jejunal Neuroendocrine Tumor AJCC v8

description: Stage IV includes: (T1, N0, N1, N2, M1); (T2, N0, N1, N2, M1); (T3, N0, N1, N2, M1); (T4, N0, N1, N2, M1). T1: Tumor invading lamina propria or submucosa and measuring 1 cm or less in size. T2: Tumor invading muscularis propria or measuring more than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis in less than 12 nodes. N2: Large mesenteric masses (larger than 2 cm) and/or extensive nodal deposits (12 or greater), especially those that encase the superior mesenteric vessels. M1: Distant metastasis. (AJCC 8th ed.)


Stage IV Rectal Cancer AJCC v7

description: Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b).  M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node).  M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Colon Adenoma with Severe Dysplasia

description: An adenoma that arises from the colon.  It is characterized by the presence of severe epithelial dysplasia.


name: Rectal Large Cell Neuroendocrine Carcinoma

description: A rare, aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the rectum. It is characterized by the presence of malignant large cells.


name: Small Intestinal Somatostatin-Producing Neuroendocrine Tumor

description: A somatostatin-producing neuroendocrine tumor that arises from the small intestine.


name: Small Intestinal Mucinous Adenocarcinoma

description: An invasive adenocarcinoma that arises from the small intestine.  It is composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation.


name: Colorectal Poorly Cohesive Adenocarcinoma

description: An adenocarcinoma that arises from the colorectal mucosa and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates.


Intestinal Intraepithelial Neoplasia

description: A precancerous neoplastic process that affects the small or large intestine.  It is characterized by low or high grade dysplasia of the mucosal epithelium.  There is no evidence of invasion.


name: Congenital Abnormality of the Large Intestine

description: A malformation in any part of the large intestine that is present at birth.


Necrotizing Enterocolitis Totalis

description: A severe and often fatal form of necrotizing enterocolitis, in which diffuse ischemia, necrosis, and pneumatosis intestinalis are evident in the small and large intestine. Short bowel syndrome is common among survivors.


name: Stage IIB Small Intestinal Adenocarcinoma AJCC v8

description: Stage IIB includes: T4, N0, M0. T4: Tumor perforating the visceral peritoneum or directly invading other organs or structures (e.g., other loops of small intestine, mesentery of adjacent loops of bowel, and abdominal wall by way of serosa; for duodenum only, invasion of pancreas or bile duct). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Colorectal Sporadic Serrated Polyp

description: A term that refers to a group of polypoid lesions in the colon and rectum that are characterized by the presence of serrated architecture of the epithelial component.  This group includes hyperplastic polyps, traditional serrated adenomas, and sessile serrated adenomas/polyps.


Rectal Epithelioid Cell Melanoma

description: An epithelioid cell melanoma arising from the rectum.


Stage IVB Rectal Cancer AJCC v7

description: Stage IVB includes: Any T, Any N, M1b. M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Undifferentiated Carcinoma of Colon

description: An invasive malignant epithelial tumor that arises from the colon.  There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation.


name: Duodenal Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of a duodenal neuroendocrine tumor according to the American Joint Committee on Cancer, 8th edition. This staging system applies to well-differentiated neuroendocrine tumors of the duodenum. Carcinomas of the duodenum, including high-grade (grade 3), poorly differentiated neuroendocrine carcinomas are not included in this staging system. (from AJCC 8th Ed.)


name: Advanced Microsatellite Stable Colorectal Carcinoma

description: A microsatellite stable carcinoma that arises from the colon or rectum and has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Jejunal Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of a jejunal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This classification system applies to small bowel "carcinoid" tumors (NET G1 and G2, and rare well-differentiated G3) arising in the jejunum. This classification system does not apply to high-grade neuroendocrine carcinomas, mixed adenoneuroendocrine carcinomas, and neuroendocrine tumors of the duodenum. (from AJCC 8th Ed.)


Juvenile Polyp of the Small Intestine

description: A non-neoplastic hamartomatous polyp that arises from the small intestine.  It is characterized by the presence of tortuous and cystically dilated glands, edematous changes, and inflammation.


Stage IIB Rectal Cancer AJCC v8

description: Stage IIB includes: T4a, N0, M0. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Large intestinal mucositis

description: An inflammatory process affecting the mucous membrane of the large intestine.


Variant Autoimmune Hepatitis

description: A form of autoimmune hepatitis (AIH) that has features of overlapping cholestatic autoimmune liver diseases including primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), or autoimmune cholangitis (AIC).


Childhood Paranasal Sinus Carcinoma

description: A rare carcinoma of the paranasal sinus that occurs during childhood.


Childhood Head and Neck Neoplasm

description: A benign or malignant neoplasm that affects the anatomic structures of the head and neck region and occurs during childhood.


Childhood Benign Head and Neck Neoplasm

description: A childhood neoplasm that arises from the head and neck and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Childhood Ameloblastic Fibroma

description: An ameloblastic fibroma that occurs during childhood.


Childhood Odontogenic Neoplasm

description: A benign or malignant neoplasm that arises from tooth-forming tissues and occurs during childhood.


name: Childhood Thyroid Gland Follicular Adenoma

description: A follicular adenoma of the thyroid gland that occurs during childhood.


name: Childhood Salivary Gland Mucoepidermoid Carcinoma

description: A mucoepidermoid carcinoma of the salivary gland that occurs during childhood.


Childhood Head and Neck NUT Carcinoma

description: A NUT carcinoma that arises from the head and neck and occurs during childhood.


Childhood Ameloblastoma

description: An ameloblastoma that occurs during childhood.


Childhood Salivary Gland Carcinoma

description: A rare carcinoma of the salivary gland that occurs during childhood.


Childhood Laryngeal Squamous Papilloma

description: A squamous papilloma of the larynx that occurs during childhood.


name: Childhood Salivary Gland Pleomorphic Adenoma

description: A salivary gland pleomorphic adenoma that occurs during childhood.


Childhood Nasal Cavity Carcinoma

description: A rare carcinoma of the nasal cavity that occurs during childhood.


Childhood Ossifying Fibroma

description: An ossifying fibroma that occurs during childhood.


Childhood Adenomatoid Odontogenic Tumor

description: An adenomatoid odontogenic tumor that occurs during childhood.


name: Childhood Salivary Gland Acinic Cell Carcinoma

description: An acinic cell carcinoma of the salivary gland that occurs during childhood.


Childhood Craniopharyngioma

description: A craniopharyngioma that occurs during childhood.  The vast majority of cases are adamantinomatous craniopharyngiomas.  Clinical signs and symptoms include endocrine deficiencies and visual disturbances.


Childhood Odontogenic Myxoma

description: An odontogenic myxoma that occurs during childhood.


description: An adamantinomatous craniopharyngioma that occurs during childhood.


name: Childhood Malignant Head and Neck Neoplasm

description: A malignant neoplasm that affects the anatomic structures of the head and neck region and occurs during childhood.


Childhood Mucoepidermoid Carcinoma

description: A mucoepidermoid carcinoma that occurs during childhood.


Bone Erdheim-Chester Disease

description: Erdheim-Chester disease affecting the bone.


pyranoxanthones

Any organic heterotetracyclic compound that consists of a pyran ring fused onto a xanthone skeleton.


Recurrent Childhood Optic Nerve Glioma

description: The reemergence of optic nerve glioma in childhood after a period of remission.


Childhood Intracranial Neoplasm

description: A neoplasm that arises within the skull and occurs during childhood.


name: Recurrent Childhood Visual Pathway Glioma

description: The reemergence of visual pathway glioma in childhood after a period of remission.


name: Childhood Supratentorial Ependymoma ZFTA Fusion-Positive

description: A supratentorial ependymoma ZFTA fusion-positive that occurs during childhood.


Childhood Supratentorial Neoplasm

description: A neoplasm that affects the supratentorial region of the brain and occurs during childhood.


Childhood Benign Brain Neoplasm

description: A childhood neoplasm that arises from the brain and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Refractory Childhood Brain Neoplasm

description: A childhood brain neoplasm that is resistant to treatment.


name: Childhood Atypical Choroid Plexus Papilloma

description: An atypical choroid plexus papilloma that occurs during childhood.


name: Childhood Pineal Parenchymal Cell Neoplasm

description: A pineal parenchymal cell neoplasm that occurs during childhood.


name: Childhood Subependymal Giant Cell Astrocytoma

description: Subependymal giant cell astrocytoma that occurs during childhood.


Childhood Gliomatosis Cerebri

description: Gliomatosis cerebri that occurs during childhood.


name: Supratentorial Ependymoma, YAP1-MAMLD1 Fusion-Positive

description: A supratentorial ependymoma characterized by a gene fusion involving YAP1 and MAMLD1 genes.


name: Metastatic Childhood Malignant Brain Neoplasm

description: A childhood malignant neoplasm that arises from the brain and has spread from its original site of growth to other anatomic sites.


name: Childhood Dysembryoplastic Neuroepithelial Tumor

description: A dysembryoplastic neuroepithelial tumor that occurs during childhood.


Recurrent Childhood Gliomatosis Cerebri

description: The reemergence of gliomatosis cerebri in childhood after a period of remission.


Recurrent Childhood Brain Neoplasm

description: The reemergence of brain neoplasm in childhood after a period of remission.


name: Childhood Pineal Parenchymal Tumor of Intermediate Differentiation

description: A pineal parenchymal tumor of intermediate differentiation that occurs during childhood.


name: Childhood Diffuse Midline Glioma, H3 K27-Altered

description: A diffuse midline glioma, H3 K27-altered that occurs during childhood.


name: Childhood Cerebral Ependymoma, Not Otherwise Specified

description: An ependymoma, not otherwise specified that arises from the cerebral hemispheres and occurs during childhood.


Childhood Brain Anaplastic Astrocytoma

description: An anaplastic astrocytoma that arises from the brain and occurs during childhood.


Childhood Brain Oligodendroglioma

description: An oligodendroglioma that arises from the brain and occurs during childhood.


Childhood Brain Glioblastoma

description: A brain glioblastoma that occurs during childhood.


Childhood Malignant Brain Neoplasm

description: A primary or metastatic malignant neoplasm affecting the brain during childhood.


name: Metastatic Childhood Malignant Neoplasm in the Brain

description: A childhood malignant neoplasm that has spread from its original site of growth to the brain.


Childhood Brain Neoplasm

description: A benign or malignant, primary or metastatic neoplasm of the brain occurring in children.


name: Childhood Benign Supratentorial Neoplasm

description: A childhood neoplasm that arises from the supratentorial region and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Childhood Multinodular and Vacuolated Neuronal Tumor

description: A multinodular and vacuolated neuronal tumor that occurs during childhood.


Childhood Cerebral Diffuse Astrocytoma

description: A diffuse astrocytoma that arises from the cerebral hemispheres and occurs during childhood.


name: Advanced Childhood Malignant Brain Neoplasm

description: A childhood malignant neoplasm that arises from the brain and has spread extensively to other anatomic sites or is no longer responding to treatment.


Childhood Benign Cerebral Neoplasm

description: A childhood neoplasm that arises from the cerebrum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Retropharyngeal Neoplasm

description: A benign or malignant neoplasm that affects the retropharyngeal space.


Malignant Retropharyngeal Neoplasm

description: A primary or metastatic malignant neoplasm that affects the retropharyngeal space.


Benign Retropharyngeal Neoplasm

description: A neoplasm that arises from the retropharyngeal space and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Group B Streptococcal Infection, Late-Onset

description: Infection of an infant from seven days to three months of life caused by Group B Streptococcus (Streptococcus agalactiae).


name: Group B Streptococcal Infection, Early-Onset

description: Infection of an infant from birth to less than seven days of life caused by Group B Streptococcus (Streptococcus agalactiae) from a colonized mother.


name: Stage IVC Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Umbilical hernia with gangrene

description: A protrusion of necrotic tissue through the abdominal wall under the skin near the umbilicus.


Cerebral abscess

description: A bacterial, fungal, or parasitic abscess that develops in the cerebral hemispheres. Causes include skull trauma, middle ear infection, congenital heart disease, and frontal and ethmoid sinus infection.


Epithelioid schwannoma

description: A schwannoma characterized by the presence of epithelioid cells with eosinophilic cytoplasm, within a myxoid and/or hyalinized stroma.


cardenolide

A steroid lactone that is a C23 steroid with methyl groups at C-10 and C-13 and a butenolide ring at C-17.


cardenolide glycoside

Any member of the class of cardenolides with glycosyl residues attached to position 3.


(S)-proglumide

The (S)-enantiomer of the racemic drug proglumide.


name: Adult Diffuse Midline Glioma, H3 K27-Altered

description: A rare diffuse midline glioma, H3 K27-altered that occurs during adulthood.


name: Metastatic Adult Malignant Neoplasm in the Brain

description: A malignant neoplasm that has spread from its original site of growth to the brain in an adult patient.


Adult Brain Glioblastoma

description: A brain glioblastoma that occurs during adulthood.


Recurrent WHO Grade 4 Glioma

description: The reemergence of WHO grade 4 glioma after a period of remission.


name: Recurrent Diffuse Midline Glioma, H3 K27M-Mutant

description: The reemergence of diffuse midline glioma, H3 K27M mutant, after a period of remission.


name: Congenital anomaly of the urinary tract proper

description: An abnormality of the kidney, ureter, bladder, or urethra that is present at birth. Representative examples include renal hypoplasia, renal agenesis, accessory kidney, absence of ureter, atresia of bladder neck, and atresia of urethra.


Urachal remnant

description: Remaining collapsed and obliterated urachal tissue between the bladder dome and umbilicus.


Posterior Urethral Valves Type 1

description: A posterior urethral valve extending from the vera montanum towards the distal meatus.


Posterior Urethral Valves Type 3

description: A posterior urethral valve, presumed to result from incomplete canalization of the urethra, that is located immediately distal to the vera montanum.


Double kidney (disorder)

description: A congenital abnormality of the kidney characterized by the presence of two separate pelvicocaliceal systems with a single or duplex ureter.


Congenital Renal Hypoplasia

description: The underdevelopment of otherwise normal renal parenchyma, characterized by decreased nephron size and possibly a decreased number of nephrons at birth.


Prostatic Duct Urothelial Carcinoma

description: An urothelial carcinoma that arises from the urothelial lining of the prostatic ducts.


name: Ann Arbor Stage II Supradiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


name: large cell neuroendocrine carcinoma of kidney

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the kidney.  It is characterized by the presence of malignant large cells.


name: Squamous cell carcinoma of the oral cavity stage I

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage I Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage I includes: T1, N0, M0. T1: Tumor 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


N-acylserotonin

A fatty amide resulting from the condensation of the carboxy group of a fatty acid with the primary amino group of serotonin.


Childhood Bone Osteosarcoma

description: An osteosarcoma that arises from the bone and occurs during childhood.


Refractory Childhood Osteosarcoma

description: Childhood osteosarcoma that is resistant to treatment.


(R)-thalidomide

A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has R-configuration at the chiral centre.


name: Benign Extrahepatic Bile Duct Non-Epithelial Neoplasm

description: A neoplasm that arises from the non-epithelial tissues of the extrahepatic bile ducts and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Extrahepatic Bile Duct Fibroma

description: A benign neoplasm arising from the extra hepatic bile duct. It is characterized by the presence of spindle-shaped fibroblasts.


name: Benign Extrahepatic Bile Duct Soft Tissue Neoplasm

description: A mesenchymal neoplasm that arises from the extrahepatic bile ducts and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Extrahepatic Bile Duct Benign Granular Cell Tumor

description: A granular cell tumor that arises from the extrahepatic bile ducts and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Pigmented epithelioid melanocytoma

description: A rare cutaneous melanocytic neoplasm that presents as a slow growing pigmented nodule or papule. It is characterized by the proliferation of heavily pigmented epithelioid and dendritic cells, predominantly in the dermis. PRKAR1A gene inactivation is present in the majority of cases. It can spread to regional lymph nodes, but distant metastases are rare.


Unresectable Pilocytic Astrocytoma

description: A pilocytic astrocytoma that is not amenable to surgical resection.


Unresectable Astrocytic Tumor

description: An astrocytic tumor that is not amenable to surgical resection.


Unresectable Glioblastoma

description: A glioblastoma that is not amenable to surgical resection.


Unresectable Astrocytoma, IDH-Mutant

description: Astrocytoma, IDH-mutant that is not amenable to surgical resection.


hydroxyindoles

Any member of the class of  indoles carrying at least one hydroxy group.


name: follicular dendritic cell sarcoma of thyroid gland

description: A rare follicular dendritic cell sarcoma involving the thyroid gland. It may be associated with chronic lymphocytic thyroiditis.


Moderate Bronchopulmonary Dysplasia

description: A chronic lung disorder associated with pulmonary maldevelopment, scarring, and/or inflammation that develops in preterm neonates exposed to supplemental oxygen for at least 28 days. For infants born before 32 weeks gestation with moderate BPD, there is a supplemental oxygen requirement of less than 30% at 36 weeks postmenstrual age or earlier discharge. For infants born after 32 weeks with moderate BPD, there is a supplemental oxygen requirement of less than 30% at 56 days post-natal age or at earlier discharge.


Kidney Lymphangioma

description: A rare lymphangioma arising from the kidney.


Prostate Hemangioma

description: A rare hemangioma that arises from the prostate gland.


Vulvar Congenital Melanocytic Nevus

description: A benign nevus that arises from the vulva and is present at birth.


Congenital small melanocytic nevus

description: A congenital melanocytic nevus of small size, with a diameter smaller than 15 mm. It presents as a macular, papular or plaque-like lesion.


name: Intermediate Congenital Melanocytic Nevus

description: A congenital melanocytic nevus measuring 15-200 mm. It is typically amenable to surgical resection.


name: Proliferative dermal lesion in congenital nevus

description: A benign proliferation of epithelioid or spindled melanocytes usually in the upper or mid dermis in a background of congenital melanocytic nevus. The congenital melanocytic nevus is usually of the deep type, involving the dermis and extending into the subcutaneous tissue. It presents as a dark plaque or nodule above a giant congenital melanocytic nevus.


name: Central Nervous System Solitary Fibrous Tumor, Grade 1

description: A solitary fibrous tumor that arises from the central nervous system. It corresponds most often to the collagenous and low cellularity spindle cell tumor which was diagnosed as central nervous system solitary fibrous tumor in the past.


name: Familial Hemophagocytic Lymphohistiocytosis Type 4

description: Familial hemophagocytic lymphohistiocytosis caused by biallelic mutations in the STX11 gene.


name: Familial Hemophagocytic Lymphohistiocytosis Type 2

description: Familial hemophagocytic lymphohistiocytosis caused by biallelic mutations in the PRF1 gene.


name: Familial Hemophagocytic Lymphohistiocytosis Type 3

description: Familial hemophagocytic lymphohistiocytosis caused by biallelic mutations in the UNC13D gene.


description: The reemergence of hemophagocytic lymphohistiocytosis after a period of remission.


description: Hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection.


name: Familial Hemophagocytic Lymphohistiocytosis Type 5

description: Familial hemophagocytic lymphohistiocytosis caused by biallelic mutations in the STXBP2 gene.


description: Hemophagocytic lymphohistiocytosis associated with a viral infection.


Renal Benign Mesenchymoma

description: A benign mesenchymoma arising from the kidney.


Mild Bronchopulmonary Dysplasia

description: A chronic lung disorder associated with pulmonary maldevelopment, scarring, and/or inflammation that develops in preterm neonates exposed to supplemental oxygen for at least 28 days. For infants born before 32 weeks gestation with mild BPD, there is no supplemental oxygen requirement at 36 weeks postmenstrual age or earlier discharge. For infants born after 32 weeks with mild BPD, there is no supplemental oxygen requirement at 56 days post-natal age or at earlier discharge.


H influenze type B Pneumonia

description: Pneumonia that is attributed to the bacteria H influenze type B.


Collapsed Lung

description: Atelectasis of an entire lung.


Community acquired pneumonia

description: Pneumonia that is not acquired in a hospital or long-term care facility setting.


name: Somatoform autonomic dysfunction - respiratory tract

description: A respiratory malfunction for which mental factors play a causative role.


Acute pneumonia

description: Acute inflammation of the lung parenchyma caused by viruses, bacteria, fungi, radiation treatment, or exposure to chemicals.  Signs and symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness.


Non-Neoplastic Lung Disorder

description: A lung disorder not caused by a neoplasm. Representative examples include chronic obstructive pulmonary disease, atelectasis, lung infections, pulmonary fibrosis, and pneumoconiosis.


Bronchiolitis Obliterans Syndrome

description: Bronchiolitis obliterans following lung or allogeneic hematopoietic cell transplantation.


Follicular Bronchitis/Bronchiolitis

description: A non-neoplastic disorder characterized by the formation of reactive lymphoid follicles adjacent to distal bronchi and bronchioles.  It presents with mild shortness of breath and is associated with immunodeficiency syndromes and collagen vascular disorders.


COVID-19-Associated Pneumonia

description: Pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is characterized by the presence of ground glass opacities on CT scan images.


Congenital anomaly of lung

description: A malformation in the lung that is present at birth. Representative examples include pulmonary hypoplasia, pulmonary agenesis, congenital lobar emphysema, and alveolar capillary dysplasia.


Pulmonary alveolitis

description: Inflammation of the alveoli of the lung.


name: Respiratory Failure Related to Neuromuscular Disorder

description: Impaired gas exchange by the respiratory system resulting in hypoxemia and decreased oxygenation of the tissues that may be associated with increased arterial levels of carbon dioxide; the respiratory failure is due to a neuromuscular disorder.


Pulmonary cryptococcosis

description: Fungal pneumonia caused by inhalation of particles of Cryptococcus.  It usually occurs in immunocompromised patients such as persons with AIDS, transplant recipients, patients receiving cytotoxic chemotherapy, and patients with hematologic malignancies.  It is rare in immunocompetent individuals.  Signs and symptoms include fever, cough, and dyspnea.


name: Pneumonia caused by respiratory syncytial virus

description: Pneumonia that is attributed to the respiratory syncytial virus.


Hospital acquired pneumonia

description: Pneumonia acquired during a hospital stay.


Paracicatricial Emphysema

description: The development of dilated terminal airspaces in the lung adjacent to parenchymal scarring.


name: Chronic obstructive asthma (with obstructive pulmonary disease)

description: Chronic airway obstruction caused by asthma.


Pulmonary vascular disorder

description: A category of non-neoplastic disorders that affect the blood vessels in the lungs.  Representative examples include pulmonary embolism, pulmonary hypertension, and arteriovenous malformations.


Steroid-Refractory Pneumonitis

description: Pneumonitis that does not respond to corticosteroid therapy.


Tuberculous bronchiectasis

description: Bronchiectasis that develops in patients with a history of pulmonary tuberculosis.  It is usually associated with healed scars but occasionally may be seen in patients with active pulmonary tuberculosis.


Severe acute respiratory infection

description: A respiratory infectious disorder that leads to an acute illness that requires medical attention.


Stannosis

description: A disorder associated with chronic exposure to inhaled tin oxide dust or fumes.


Severe Bronchopulmonary Dysplasia

description: Bronchopulmonary dysplasia that results in severe respiratory complications. The infants with severe symptoms are usually premature, have low birth weight, and the oxygen and ventilation support requirements are increased.


name: Pneumonia caused by methicillin resistant Staphylococcus aureus

description: Pneumonia that is caused by Staphylococcus aureus that is resistant to methicillin treatment.


Cannabinosis

description: A disorder associated with chronic exposure to inhaled dust during the processing of hemp.


Asbestos-Related Lung Disorder

description: A disorder affecting the lungs due to asbestos exposure. Examples include asbestosis and lung carcinoma.


Toxoplasma Pneumonia

description: Pneumonia caused by the parasite Toxoplasma gondii.  It usually presents as an opportunistic infection in immunocompromised patients, especially patients with AIDS.  It is rare in immunocompetent individuals.  Signs and symptoms include cough, fever, and dyspnea.


Secondary Pneumonia

description: A pneumonia that occurs during or following treatment for an acute (primary) pneumonia that was caused by a different organism. It may be the result of increased susceptibility due to the initial treatment.


Pulmonary trunk hypoplasia

description: Underdeveloped pulmonary arteries.


Non-cardiogenic pulmonary edema

description: Pulmonary edema that is not a result of cardiac dysfunction.


name: Respiratory Failure Related to Central Nervous System Disorder

description: Impaired gas exchange by the respiratory system resulting in hypoxemia and decreased oxygenation of the tissues that may be associated with increased arterial levels of carbon dioxide; the respiratory failure is due to a central nervous system disorder.


name: Autoimmune Pulmonary Alveolar Proteinosis

description: A type of pulmonary alveolar proteinosis associated with low concentrations of GM-CSF.


Sickle Cell Chronic Lung Disease

description: A pulmonary complication of sickle cell disease characterized by radiographic interstitial abnormalities and impaired pulmonary function. In severe cases, pulmonary hypertension is present.


Atypical pneumonia

description: Historical term that references a form of pneumonia caused by Mycoplasma pneumoniae, Chlamydophila pneumoniae, or Legionella species.


Hyaline Membrane Syndrome

description: A serious disorder affecting newborns, particularly premature infants. It is caused by deficiency of surfactant, resulting in the formation of a membrane in the alveoli lining. This membrane contains fibrin and cellular debris and interferes with respiration. Infants with this disorder develop breathing problems immediately or in a few hours after delivery. It may lead to respiratory failure.


Fibrotic Hypersensitivity Pneumonitis

description: Interstitial lung fibrosis resulting from chronic hypersensitivity pneumonitis.


AIDS-Related Pneumocystis Pneumonia

description: A serious AIDS-related opportunistic infection of the lungs, caused by Pneumocystis jirovecii.  It is one of the most common AIDS-related illnesses and is a major cause of morbidity in patients with AIDS.  Signs and symptoms include cough, fever, dyspnea, and pain or tightness in the chest.


Pulmonary Precancerous Condition

description: A premalignant pathologic process that affects the lungs.  This category includes bronchial intraepithelial neoplasia and atypical adenomatous hyperplasia.


Acute pulmonary edema

description: Rapid or severe onset or rapid progression of pulmonary edema causing significant hypoxemia or the need for supplemental oxygen.


Diffuse Panbronchiolitis

description: A clinico-pathologic syndrome primarily affecting the respiratory bronchioles with evidence of inflammation in all layers of the bronchiole. Sinusitis is often an accompanying feature.


Mesothelial hyperplasia

description: A hyperplasia of the mesothelial cells.


Atypical Mesothelial Hyperplasia

description: An atypical hyperplasia of the mesothelial cells.


Infectious Salpingitis

description: An acute or chronic infectious process affecting the fallopian tube. Chlamydia trachomatis, Neisseria gonorrhea, Mycoplasma, Staphylococcus, and Streptococcus are the most common causative agents.


Conjunctival Rhabdomyosarcoma

description: A rhabdomyosarcoma that arises from the conjunctiva.


onium betaine

Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


saturated fatty acyl-L-carnitine

An O-acylcarnitine in which the R is a saturated fatty acyl chain.


nitrilium betaine

Derivatives of nitriles having the general structure R-C#N(+)-Y(-). A subclass of 1,3-dipolar compounds including nitrile imides, nitrile oxides, nitrile sulfides and nitrile ylides.


O-acylcarnitine

Any carboxylic ester obtained by the O-acylation of carnitine.


fatty acyl-L-carnitine

Any O-acylcarnitine in which the carnitine component has L-configuration and the acyl group is a fatty acid.


nitrile oxide

Compounds having the structure R-C#NO.


monounsaturated fatty acyl-L-carnitine

An O-acylcarnitine in which the R is a monounsaturated fatty acyl chain.


O-acyl-L-carnitine

An O-acylcarnitine in which the carnitine component has L-configuration.


ammonium betaine

Any neutral molecule having charge-separated forms with a quaternary ammonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


Palmitoyl-carnitine

An O-acylcarnitine having palmitoyl (hexadecanoyl) as the acyl substituent.


name: Stage IA Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: pT1, N0, M0, S0. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Immature Teratoma

description: An immature teratoma occurring in children.


name: Localized Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Tumor confined to the testes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Choriocarcinoma

description: A choriocarcinoma occurring in children.


name: Stage III Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, Any N, M1, SX. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Testicular Yolk Sac Tumor, Prepubertal-Type

description: Testicular yolk sac tumor that almost always occurs in pure form and is not associated with germ cell neoplasia in situ. It affects young children and is the most frequently seen testicular neoplasm in prepubertal children.


Childhood Mature Teratoma

description: A mature teratoma occurring in children.


name: Refractory Childhood Malignant Germ Cell Tumor

description: A malignant germ cell tumor that occurs during childhood and is resistant to treatment.


name: Stage IIIC Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N1-N3, M0, S3 or Any pT, Any N, M1, S3. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage IIIB Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N1-N3, M0, S2 or Any pT, Any N, M1, S2. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Childhood Malignant Testicular Germ Cell Tumor

description: A malignant germ cell tumor in children arising from the testis.  It includes the embryonal carcinoma, yolk sac tumor, choriocarcinoma, and mixed germ cell tumors.


name: Recurrent Childhood Malignant Germ Cell Tumor

description: The reemergence of a malignant germ cell tumor in children after a period of remission.


name: Stage IB Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: pT2-4, N0, M0, S0. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Germinomatous Germ Cell Tumor

description: A germinomatous germ cell tumor occurring in children.


Childhood Mixed Germ Cell Tumor

description: A mixed germ cell tumor occurring in children.


name: Stage IIA Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N1, M0, S0, S1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage II Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N1-3, M0, SX. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Extracranial Germ Cell Tumor

description: A childhood benign or malignant germ cell tumor arising from an anatomic site other than the brain.


name: Metastatic Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Teratoma

description: A mature or immature teratoma occurring in children.


Childhood Seminoma

description: A seminoma occurring in children.


Childhood Embryonal Carcinoma

description: An embryonal carcinoma occurring in children.


Childhood Extragonadal Teratoma

description: An extragonadal teratoma that occurs during childhood.


name: Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood testicular germ cell tumor according to the tier 2 Toronto childhood cancer staging guidelines v2.


name: Regional Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Tumor extension to regional lymph nodes: interaortocaval, para-aortic (periaortic), paracaval, preaortic, precaval, retroaortic, retrocaval, and along spermatic cord. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage IIB Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N2, M0, S0, S1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Childhood Extragonadal Malignant Germ Cell Tumor

description: A malignant germ cell tumor in children arising from an anatomic site other than the testis or ovary.


name: Childhood Central Nervous System Teratoma

description: A mature or immature teratoma affecting the central nervous system and occurring in children.


Childhood Benign Germ Cell Tumor

description: A germ cell tumor that occurs during childhood and is characterized by the absence of atypia and metastatic potential.


name: Childhood Nongerminomatous Germ Cell Tumor

description: A nongerminomatous germ cell tumor occurring in children.


name: Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood testicular germ cell tumor according to the tier 1 Toronto childhood cancer staging guidelines v2.


name: Childhood Testicular Non-Seminomatous Germ Cell Tumor

description: A non-seminomatous germ cell tumor that arises in the testis and occurs in children.


name: Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood testicular germ cell tumor according to the Toronto childhood cancer staging guidelines v2.


name: Stage IS Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N0, M0, S1-3. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage I Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: pT1-4, N0, M0, SX. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage IIC Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N3, M0, S0, S1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Testicular Yolk Sac Tumor

description: A yolk sac tumor that arises from the testis during childhood.


Intermediate Grade Osteosarcoma

description: An osteosarcoma with intermediate-grade morphological features. A representative example is periosteal osteosarcoma.


name: Peripheral Nervous System Infectious Disorder

description: An infectious process affecting the peripheral nerves.


B-Cell Malignant Neoplasm

description: A clonal lymphoproliferative disorder composed of neoplastic B-cells. It includes B-cell non-Hodgkin lymphomas, B-cell leukemias, and plasma cell myeloma.


Chronic lymphocytic leukemia stage 1

description: Risk: Intermediate; Findings: Lymphocytosis and adenopathy; Survival (months): 95. (from AJCC 8th Ed.)


name: Multiple Myeloma with MAF Family Translocation

description: Multiple myeloma characterized by the presence of a translocation involving a MAF family gene.


DS Stage IA Multiple Myeloma

description: Durie/Salmon stage I multiple myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


name: B Acute Lymphoblastic Leukemia with t(4;11)(q21;23.3); KMT2A-AFF1

description: A B-cell acute lymphoblastic leukemia associated with t(4;11)(q21;23.3). This translocation leads to the generation of the fusion gene KMT2A-AFF1.


name: Childhood B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

description: A B acute lymphoblastic leukemia that occurs during childhood. It is characterized by the presence of lymphoblasts that carry a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. It results in the production of the p190 kd or p210 kd fusion protein. It has an unfavorable clinical outcome.


name: Hypodiploid B Acute Lymphoblastic Leukemia

description: A B-cell acute leukemia characterized by the presence of lymphoblasts which contain less than 46 chromosomes. It occurs in both children and adults. It has an unfavorable clinical outcome.


Recurrent Chronic Lymphoid Leukemia

description: The reemergence of chronic lymphocytic leukemia after a period of remission.


name: Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

description: Chronic lymphocytic leukemia/small lymphocytic lymphoma that does not respond to treatment.


name: Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

description: The reemergence of chronic lymphocytic leukemia/small lymphocytic lymphoma after a period of remission.


name: Refractory B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

description: B-acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 that is resistant to treatment.


Leptomeningeal myelomatosis

description: A central nervous system multiple myeloma involving the leptomeninges.


name: B Acute Lymphoblastic Leukemia with Recurrent Genetic Abnormalities

description: B-acute lymphoblastic leukemias characterized by the presence of recurring cytogenetic and/or molecular abnormalities.


name: Refractory B Acute Lymphoblastic Leukemia

description: B-acute lymphoblastic leukemia that does not respond to treatment.


Plasma cell myeloma recurrent

description: The reemergence of multiple myeloma after a period of remission.


DS Stage IIIB Multiple Myeloma

description: Durie/Salmon stage III multiple myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


name: Recurrent B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

description: The reemergence of  B-acute lymphoblastic leukemia, BCR-ABL1-like after a period of remission.


name: B Acute Lymphoblastic Leukemia with ETV6-RUNX1-Like Features

description: B acute lymphoblastic leukemia characterized by a gene-expression profile similar to that of ETV6-RUNX1-positive B acute lymphoblastic leukemia, absence of the pathognomonic ETV6-RUNX1 rearrangement, and rearrangements or deletions of ETV6 and IKZF1 genes.


name: Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder

description: A clonal B-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed B-lymphocytes or plasma cells. The clonal cellular infiltrates fulfill the criteria for a diffuse large B-cell lymphoma, Burkitt lymphoma, or a plasma cell neoplasm.


name: Recurrent B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

description: The reemergence of B acute lymphoblastic leukemia, Philadelphia chromosome negative, after a period of remission.


name: Multiple Myeloma, Not Otherwise Specified

description: Multiple myelomas characterized by the absence of recurrent genetic abnormalities.


name: B Acute Lymphoblastic Leukemia, Not Otherwise Specified

description: B-acute lymphoblastic leukemias characterized by the absence of recurrent genetic abnormalities.


name: Extramedullary Disease in Multiple Myeloma Involving the Central Nervous System

description: Multiple myeloma involving the central nervous system. It manifests with single or multiple intraparenchymal lesions and/or leptomeningeal involvement. Patients present with diffuse cerebral dysfunction and nerve paralysis. The prognosis is poor.


Stage A Chronic Lymphocytic Leukemia

description: Findings: Lymphocytosis only; Survival (months): more than 120. (from AJCC 8th Ed.)


name: Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene

description: Chronic lymphocytic leukemia characterized by the absence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a significantly worse prognosis as compared to those with mutated immunoglobulin heavy chain gene variable region rearrangements.


name: B Acute Lymphoblastic Leukemia with Mutated ZEB2 (p.H1038R)

description: B-acute lymphoblastic leukemia associated with mutations in the ZEB2 gene that encode a histidine to arginine amino acid substitution at codon 1038. This variation appears to phenocopy the IGH-CEBPE gene fusion. This is a provisional entity.


name: Refractory B-Cell Prolymphocytic Leukemia

description: B-cell prolymphocytic leukemia that is resistant to treatment.


name: Chronic Lymphocytic Leukemia- Binet Staging System

description: A term that refers to the staging of chronic lymphocytic leukemia according to Binet staging system. This system is in wide use outside the United States.


Chronic lymphocytic leukemia stage 4

description: Risk: High; Findings: Lymphocytosis and platelets less than 100,000/microliter; Survival (months): 30. (from AJCC 8th Ed.)


name: Cutaneous B Lymphoblastic Leukemia/Lymphoma

description: B-lymphoblastic leukemia/lymphoma that affects the skin.


Recurrent Extraosseous Plasmacytoma

description: The reemergence of extraosseous plasmacytoma after a period of remission.


Recurrent Solitary Plasmacytoma

description: The reemergence of solitary plasmacytoma after a period of remission.


Stage B Chronic Lymphocytic Leukemia

description: Findings: Lymphocytosis and adenopathy; Survival (months): 95. (from AJCC 8th Ed.)


name: Multiple Myeloma Post-Transplant Lymphoproliferative Disorder

description: A lymphoproliferative disorder that develops following an organ transplantation and exhibits multiple myeloma features.


name: Multiple Myeloma with Recurrent Genetic Abnormalities

description: Multiple myelomas characterized by the presence of recurring cytogenetic abnormalities.


name: Plasmacytoma-Like Post-Transplant Lymphoproliferative Disorder

description: A plasmacytoma-like hematologic malignancy that arises in a patient with a history of organ transplantation.


name: B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 with Multilineage Involvement

description: B-acute lymphoblastic leukemia associated with t(9;22)(q34.1;q11.2); BCR-ABL1 and characterized by both lymphoblastic and differentiating myeloid cell proliferation.


name: B Acute Lymphoblastic Leukemia with Germline IKZF1 Mutation

description: B-acute lymphoblastic leukemia that results from germline mutation of the IKZF1 gene.


Chronic lymphocytic leukemia stage 2

description: Risk: Intermediate; Findings: Lymphocytosis, adenopathy, and enlarged spleen and/or liver; Survival (months): 72. (from AJCC 8th Ed.)


name: Adult B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

description: A B acute lymphoblastic leukemia that occurs during adulthood. It is characterized by the presence of lymphoblasts that carry a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. It results in the production of the p190 kd or p210 kd fusion protein. It has an unfavorable clinical outcome.


Refractory B-Cell Malignant Neoplasm

description: A B-cell malignant neoplasm that is resistant to treatment.


name: Multiple Myeloma with CCND Family Translocation

description: Multiple myeloma characterized by the presence of a translocation involving a CCND family gene.


RISS Stage I Multiple Myeloma

description: Serum beta-2-microglobulin less than 3.5 mg/L and serum albumin 3.5 g/dL or more and no high-risk cytogenetics and normal LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.)


DS Stage IIB Multiple Myeloma

description: Durie/Salmon stage II multiple myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


name: Chronic Lymphocytic Leukemia with Plasmacytoid Differentiation

description: A chronic lymphocytic leukemia characterized by the presence of neoplastic lymphocytes with plasmacytoid morphology.


name: Near-Haploid B Acute Lymphoblastic Leukemia

description: B-acute lymphoblastic leukemia associated with a near haploid karyotype.


name: B Acute Lymphoblastic Leukemia with IKZF1 N159Y Mutation

description: B-acute lymphoblastic leukemia associated with IKZF1 missense mutation p.Asn159Tyr (N159Y).


name: B Acute Lymphoblastic Leukemia with UBTF-ATXN7L3/PAN3, CDX2 ("CDX2/UBTF")

description: B-acute lymphoblastic leukemia associated with concomitant CDX2 deregulation and expression of the chimeric UBTF-ATXN7L3 fusion oncoprotein. It usually affects female adolescents and young adults. The prognosis is poor following treatment with conventional chemotherapy.


name: Extramedullary Disease in Plasma Cell Myeloma

description: Infiltration of organs and soft tissues by malignant (clonal) plasma cells in patients with history of multiple myeloma. Skin, liver, lymph nodes, pleura, and central nervous system are the most frequently affected sites.


Head and Neck Plasmacytoma

description: A plasmacytoma that arises from the head and neck region.


Sinonasal Plasmacytoma

description: A plasmacytoma that arises from the sinonasal tract.


DS Stage IIA Multiple Myeloma

description: Durie/Salmon stage II multiple myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


name: Progressive Hairy Cell Leukemia Initial Treatment

description: A hairy cell leukemia requiring initial treatment because of the presence of signs of progression.  Signs of progression include cytopenia (especially if symptomatic), increasing splenomegaly, and infectious complications.  Therapy is not necessary if the patients are asymptomatic and the blood counts are maintained in an acceptable range.


name: Refractory Transformed Chronic Lymphocytic Leukemia

description: Chronic lymphocytic leukemia which has undergone histologic transformation to an aggressive diffuse large B-cell lymphoma (Richter's transformation) and has become resistant to treatment.


name: B Lymphoblastic Leukemia/Lymphoma with MYC Rearrangement

description: B-lymphoblastic leukemia/lymphoma associated with MYC gene rearrangement. The prognosis is poor.


Primary cutaneous plasmacytoma

description: A plasmacytoma that arises in the skin.


name: B Acute Lymphoblastic Leukemia with PAX5 Alteration

description: B-acute lymphoblastic leukemia associated with PAX5 gene alteration, including rearrangements, point mutations, and intragenic lesions. This is a provisional entity.


name: B Lymphoblastic Leukemia/Lymphoma with TCF3-HLF Rearrangement

description: An exceptionally rare childhood B-lymphoblastic leukemia/lymphoma associated with TCF3-HLF gene rearrangement resulting in the formation of TCF3-HLF chimeric transcription factor. The prognosis is poor.


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, JAK-STAT Activated

description: B-acute lymphoblastic leukemia, BCR-ABL1-like associated with aberrant activation of the JAK-STAT signaling pathway.


name: Chronic Lymphocytic Leukemia with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation

description: Chronic lymphocytic leukemia characterized by the presence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a better prognosis as compared to those with unmutated immunoglobulin heavy chain gene variable region rearrangements.


Plasma cell myeloma refractory

description: Multiple myeloma that is resistant to treatment.


Testicular Plasmacytoma

description: A rare plasmacytoma that arises in the testis. At presentation the involvement is usually unilateral.


name: B Acute Lymphoblastic Leukemia with Germline PAX5 Mutation

description: B-acute lymphoblastic leukemia that results from germline mutation of the PAX5 gene.


DS Stage II Plasma Cell Myeloma

description: Multiple myeloma that fits in neither stage I nor stage III.  Estimated myeloma cell mass: 0.6 to 1.2 trillion (1012)/m2 (intermediate burden).  The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL.  Impaired renal function worsens prognosis regardless of stage.  Note that the newer International Staging System defines stage II quite differently: Beta-2-microglobulin less than 3.5 and albumin less than 3.5 or beta-2-microglobulin 3.5 to less than 5.5 (median survival of 44 months).  (PDQ)


name: B Acute Lymphoblastic Leukemia with MEF2D Rearrangement

description: B-acute lymphoblastic leukemia associated with MEF2D gene rearrangement. The prognosis is poor.


Chronic lymphocytic leukemia refractory

description: Chronic lymphocytic leukemia that is resistant to treatment.


name: Transformed Chronic Lymphocytic Leukemia to Hodgkin Lymphoma

description: Histologic transformation of chronic lymphocytic leukemia to Hodgkin lymphoma.


name: Recurrent B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

description: The reemergence of B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 after a period of remission.


name: Extramedullary Disease in Multiple Myeloma Involving the Uterine Corpus

description: Infiltration of the uterine corpus by malignant (clonal) plasma cells in patients with history of multiple myeloma.


name: Childhood B Lymphoblastic Leukemia/Lymphoma

description: B lymphoblastic leukemia/lymphoma that occurs during childhood.


Multiple Myeloma with t(11;14)(q13;q32)

description: Multiple myeloma characterized by the presence of t(11;14)(q13;q32). It is the most common immunoglobulin heavy chain translocation found in multiple myeloma and results in CCND1 overexpression.


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

description: B acute lymphoblastic leukemia characterized by a gene-expression profile similar to that of BCR-ABL1-positive B acute lymphoblastic leukemia, absence of the pathognomonic BCR-ABL1 rearrangement, alterations of lymphoid transcription factor genes, and a poor outcome.


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, ABL1 Rearranged

description: B-acute lymphoblastic leukemia, BCR-ABL1-like associated with ABL1 gene rearrangement.


name: Chronic Lymphocytic Leukemia- Modified Rai Staging System

description: A term that refers to the staging of chronic lymphocytic leukemia according to modified Rai staging system. This system is mainly used in North America.


Chronic lymphocytic leukemia stage 3

description: Risk: High; Findings: Lymphocytosis and hemoglobin less than 11 g/dL; Survival (months): 30. (from AJCC 8th Ed.)


RISS Stage II Multiple Myeloma

description: Not stage I or III. (from AJCC 8th Ed.)


name: Low-Hypodiploid B Acute Lymphoblastic Leukemia

description: B-acute lymphoblastic leukemia associated with a low hypodiploid karyotype.


Multiple Myeloma by ISS Stage

description: A header term that refers to the staging of multiple myeloma according to the International Staging System.


Recurrent Burkitt Leukemia

description: The reemergence of Burkitt leukemia after a period of remission.


name: Plasma Cell Post-Transplant Lymphoproliferative Disorder

description: A plasma cell neoplasm that arises in a patient with a history of organ transplantation.


Multiple Myeloma by RISS Stage

description: A staging system for multiple myeloma based on the Revised International Staging System (RISS) criteria. This staging system does not apply to smoldering multiple myeloma (no AJCC staging system), monoclonal gammopathy of undetermined significance (no AJCC staging system), and Waldenstrom macroglobulinemia (no AJCC staging system). (from AJCC 8th Ed.)


name: B Acute Lymphoblastic Leukemia with Germline Predisposition

description: B-acute lymphoblastic leukemia that results from germline gene mutations. This category includes B-acute lymphoblastic leukemia with germline PAX5 mutation and B-acute lymphoblastic leukemia with germline IKZF1 mutation.


Adult Burkitt Leukemia

description: The leukemic counterpart of Burkitt lymphoma occurring in adults.  The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood.  This is an aggressive leukemia.


ISS Stage II Plasma Cell Myeloma

description: Multiple myeloma with blood levels of beta-2-microglobulin between 3.5 and 5.5 mg/L.


Recurrent B-Cell Malignant Neoplasm

description: The reemergence of a B-cell malignant neoplasm after a period of remission.


Plasmacytoma anaplastic

description: A plasmacytoma characterized by the presence of malignant plasma cells with anaplastic features.


name: B Acute Lymphoblastic Leukemia with MYC Rearrangement

description: B-acute lymphoblastic leukemia associated with MYC gene rearrangement. The prognosis is poor.


Refractory Burkitt Leukemia

description: Burkitt leukemia resistant to treatment.


name: Multiple Myeloma with NSD2 Translocation

description: Multiple myeloma characterized by the presence of a translocation involving the NSD2 gene.


name: Recurrent Transformed Chronic Lymphocytic Leukemia

description: The reemergence of chronic lymphocytic leukemia transformed to aggressive diffuse large B-cell lymphoma (Richter's transformation) after a period of remission.


name: Extramedullary Disease in Multiple Myeloma Involving the Skin

description: Infiltration of the skin by malignant (clonal) plasma cells in patients with history of multiple myeloma.


Advanced B-Cell Malignant Neoplasm

description: A B-cell malignant neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: B Acute Lymphoblastic Leukemia with ZNF384 Rearrangement

description: B-acute lymphoblastic leukemia associated with ZNF384 gene rearrangement. The prognosis is variable.


name: B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 with Lymphoid Only Involvement

description: B-acute lymphoblastic leukemia associated with t(9;22)(q34.1;q11.2); BCR-ABL1 and characterized by lymphoblastic proliferation without differentiating myeloid cell proliferation.


Stage C Chronic Lymphocytic Leukemia

description: Findings: Lymphocytosis, adenopathy, and enlarged spleen and/or liver; Survival (months): 72. (from AJCC 8th Ed.)


Cutaneous Chronic Lymphocytic Leukemia

description: A chronic lymphocytic leukemia that affects the skin.


DS Stage III Plasma Cell Myeloma

description: Multiple myeloma with one or more of the following: 1. Hemoglobin less than 8.5 g/dL. 2. Serum calcium greater than 12.0 mg/dL. 3. More than three lytic bone lesions. 4. High M protein production as shown by: a. IgG greater than 7.0 g/dL. b. IgA greater than 5.0 g/dL. c. Urinary kappa or lamda greater than 12.0 g/24 hours. Estimated myeloma cell mass: greater than 1.2 trillion (1012)/m2 (high burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL. b. Creatinine greater than or equal to 2.0 mg/dL. Serum beta-2-microglobulin has been shown to be a reliable marker for prognosis. Since the great majority of symptomatic myeloma patients are classified as stage III by the Durie/Salmon criteria, this staging system has not proven to be very useful for identifying the patients with intermediate and poor prognosis. Note that the newer International Staging System defines stage III quite differently: Beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months). (PDQ)


DS Stage I Plasma Cell Myeloma

description: Multiple myeloma with all of the following: 1. Hemoglobin greater than 10 g/Dl, 2. Normal serum calcium, 3. Normal bone structure, 4. Low monoclonal (or myeloma) protein (M protein) production as shown by: a. IgG less than 5.0 g/dL, b. IgA less than 3.0 g/dL, c. Urinary kappa or lamda less than 4 g/24 hours. Estimated myeloma cell mass: less than 0.6 trillion (1012)/m2 (low burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL. Impaired renal function worsens prognosis regardless of stage. Note that the newer International Staging System defines stage I quite differently: Beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months). (PDQ)


name: B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

description: A B-acute lymphoblastic leukemia (B-ALL) that does not have the cytogenetic abnormality t(9;22)(q34;q11.2). Most cases of B-ALL do not have this translocation.


DS Stage IIIA Multiple Myeloma

description: Durie/Salmon stage III multiple myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


name: B Lymphoblastic Leukemia/Lymphoma with ETV6-RUNX1-Like Features

description: B lymphoblastic leukemia/lymphoma characterized by a gene-expression profile similar to that of ETV6-RUNX1-positive B lymphoblastic leukemia/lymphoma, absence of the pathognomonic ETV6-RUNX1 rearrangement, and rearrangements or deletions of ETV6 and IKZF1 genes.


name: Recurrent B Acute Lymphoblastic Leukemia

description: The reemergence of B acute lymphoblastic leukemia after a period of remission.


RISS Stage III Multiple Myeloma

description: Serum beta-2-microglobulin 5.5 mg/L or more and high-risk cytogenetics and/or high LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.)


name: B Acute Lymphoblastic Leukemia Associated with Down Syndrome

description: A B-acute lymphoblastic leukemia that occurs in patients with Down syndrome. It usually affects young children, but it can occur in adults as well. It has an unfavorable clinical outcome. Cases of T-acute lymphoblastic leukemia in patients with Down syndrome have not been reported.


name: Hyperdiploid B Acute Lymphoblastic Leukemia

description: A B-cell acute leukemia characterized by the presence of lymphoblasts which contain more than 50 and usually less than 66 chromosomes. It is commonly seen in children and rarely in adults. It has a favorable clinical outcome.


name: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

description: B-lymphoblastic leukemias/lymphomas characterized by the absence of recurrent genetic abnormalities.


name: B Acute Lymphoblastic Leukemia with NUTM1 Rearrangement

description: B-acute lymphoblastic leukemia associated with NUTM1 gene rearrangement. The prognosis is good.


ISS Stage III Plasma Cell Myeloma

description: Multiple myeloma with beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months).  Note that the older Durie/Salmon staging system defines stage III quite differently. (PDQ)


DS Stage IB Multiple Myeloma

description: Durie/Salmon stage I multiple myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, ABL Class Rearranged

description: B-acute lymphoblastic leukemia, BCR-ABL1-like associated with rearrangement of an ABL class gene (e.g., ABL1, ABL2, CSF1R, PDGFRA, and PDGFRB).


name: Recurrent B-Cell Prolymphocytic Leukemia

description: The reemergence of a B-cell prolymphocytic leukemia after a period of remission.


name: Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of an indolent chronic lymphocytic leukemia to an aggressive diffuse large B-cell lymphoma.


name: Extramedullary Disease in Multiple Myeloma Involving the Kidney

description: Infiltration of the kidney by malignant (clonal) plasma cells in patients with history of multiple myeloma.


Multiple Myeloma with Hyperdiploidy

description: Multiple myeloma characterized by the presence of plasma cells in which the chromosomal number is greater than the normal diploid number.


Chronic lymphocytic leukemia stage 0

description: Risk: Low; Findings: Lymphocytosis only; Survival (months): more than 120. (from AJCC 8th Ed.)


name: Refractory B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

description: B acute lymphoblastic leukemia, Philadelphia chromosome negative, that does not respond to treatment.


name: B Acute Lymphoblastic Leukemia with ZNF362 Rearrangement

description: B-acute lymphoblastic leukemia associated with ZNF362 gene rearrangement. The prognosis is variable.


name: Refractory B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

description: B-acute lymphoblastic leukemia, BCR-ABL1-like that does not respond to treatment.


ISS Stage I Plasma Cell Myeloma

description: Multiple myeloma with beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months).  Note that the older Durie/Salmon staging system defines stage I quite differently. (PDQ)


name: B-lymphoblastic leukemia lymphoma BCR-ABL1-like

description: B lymphoblastic leukemia/lymphoma characterized by a gene-expression profile similar to that of BCR-ABL1-positive B lymphoblastic leukemia/lymphoma, absence of the pathognomonic BCR-ABL1 rearrangement, alterations of lymphoid transcription factor genes, and a poor outcome.


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, Not Otherwise Specified

description: B-acute lymphoblastic leukemia, BCR-ABL1-like in which further genetic/molecular characterization is not available.


Multiple Myeloma Myeloma by DS Stage

description: A header term that refers to the staging of multiple myeloma according to the Durie/Salmon staging system.


Childhood Burkitt Leukemia

description: The leukemic counterpart of Burkitt lymphoma occurring in children.  The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood.  This is an aggressive leukemia.


Nasal Cavity Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that arises from the nasal cavity.


Nasal Cavity Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the nasal cavity.


name: Nasal Cavity Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that arises from the nasal cavity.


name: Nasal Cavity Small Cell Neuroendocrine Carcinoma

description: A small cell neuroendocrine carcinoma that arises from the nasal cavity.


name: Penile Undifferentiated Pleomorphic Sarcoma

description: A rare undifferentiated pleomorphic sarcoma that occurs in the penis.


Non-Neoplastic Vision Disorder

description: A non-neoplastic disorder that causes a disturbance in normal vision. Representative examples include amblyopia, astigmatism, myopia, and cataracts.


Optical Illusion

description: The visual perception of an image that differs from the reality of the image.


name: Advanced Extracranial Malignant Solid Neoplasm

description: A malignant solid neoplasm that arises from any anatomic site other than the brain and has spread extensively to other anatomic sites or is no longer responding to treatment.


Ciliary Body Adenocarcinoma

description: An adenocarcinoma arising from the pigmented or non-pigmented ciliary epithelium.


Stage IIB Uveal Melanoma AJCC v7

description: Stage IIB includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement.  T3a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with sclera extension and secondary glaucoma. Ciliary body and choroid: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIA Uveal Melanoma AJCC v7

description: Stage IIA includes: (T1b-d, N0, M0); (T2a, N0, M0). T1b: Iris: Tumor limited to the iris more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 with ciliary body involvement.  T1c: Iris: Tumor limited to the iris with secondary glaucoma.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T1d: Ciliary body and choroid: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T2a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with secondary glaucoma.  Ciliary body and choroid: Tumor size category 2 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Metastatic Choroid Melanoma

description: Choroid melanoma that has spread from its primary site to another anatomic site.


name: Metastatic Malignant Neoplasm in the Uvea

description: A malignant neoplasm that has spread to the uvea from another anatomic site.


Uveal Melanocytoma

description: A subtype of ciliary body, iris, and choroidal nevi. It is intensely pigmented and composed of large, plump, polyhedral cells.


Choroid Spindle Cell Type A Melanoma

description: A choroid melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


name: Uveal Melanoma by Gene Expression Profile


name: Locally Advanced Unresectable Uveal Melanoma

description: Uveal melanoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Uveal Spindle Cell Type A Melanoma

description: A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Stage III Uveal Melanoma AJCC v7

description: Stage III includes: IIIA (T2c-d, N0, M0); (T3b-c, N0, M0); (T4a, N0, M0); IIIB (T3d, N0, M0); (T4b-c, N0, M0); IIIC (T4d-e, N0, M0).  T2c: Ciliary body and choroid: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T2d: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T3b: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement. T3c: Ciliary body and choroid: Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T4a: Iris: Tumor with extrascleral extension less than or equal to 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 without ciliary body involvement and extraocular extension.  T3d: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4b: Iris: Tumor with extrascleral extension more than 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 with ciliary body involvement.  T4c: Ciliary body and choroid: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T4d: Ciliary body and choroid: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4e: Ciliary body and choroid: Any tumor size category with extraocular extension more than 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Uveal Class 2 Melanoma

description: Gene expression profiling that classifies uveal melanomas into a high-grade group.


Uveal Class 1a Melanoma

description: Uveal melanoma with low metastatic risk as defined by gene expression profiling.


Ciliary Body Nevus

description: A benign nevus that arises from the ciliary body. Only a small percentage of cases progress to ciliary body melanoma.


Stage IIIC Uveal Melanoma AJCC v7

description: Stage IIIC includes: T4d-e, N0, M0.  T4d: Ciliary body and choroid: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4e: Ciliary body and choroid: Any tumor size category with extraocular extension more than 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Refractory Uveal Melanoma

description: Uveal melanoma that is resistant to treatment.


Choroidal Ganglioneuroma

description: A rare ganglioneuroma that arises from the choroid.


Uveal Melanocytic Neoplasm

description: A melanocytic neoplasm that arises from the iris, ciliary body, and choroid. This category includes nevus and its subtype melanocytoma, and melanoma.


name: Choroidal and Ciliary Body Melanoma by AJCC v8 Stage

description: A term that refers to the staging of choroidal and ciliary body melanoma, following the rules of the TNM AJCC v8 classification system.


Unresectable Uveal Melanoma

description: Uveal melanoma that is not amenable to surgical resection.


name: Stage IIB Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IIB includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Tumor size category 2 with ciliary body involvement. T3a: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Choroid Spindle Cell Type B Melanoma

description: A choroid melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


name: Stage IIIB Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IIIB includes: (T3d, N0, M0); (T4b-c, N0, M0). T3d: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter.  T4b: Tumor size category 4 with ciliary body involvement. T4c: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Uveal Class 1b Melanoma

description: Uveal melanoma with intermediate metastatic risk as defined by gene expression profiling.


name: Ciliary Body Spindle Cell Type B Melanoma

description: A ciliary body melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Stage II Uveal Melanoma AJCC v7

description: Stage II includes: IIA (T1b-d, N0, M0); (T2a, N0, M0); IIB (T2b, N0, M0); (T3a, N0, M0).  T1b: Iris: Tumor limited to the iris more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 with ciliary body involvement.  T1c: Iris: Tumor limited to the iris with secondary glaucoma.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T1d: Ciliary body and choroid: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T2a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with secondary glaucoma.  Ciliary body and choroid: Tumor size category 2 without ciliary body involvement and extraocular extension. T2b: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement.  T3a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with sclera extension and secondary glaucoma. Ciliary body and choroid: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Stage III Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage III includes: IIIA (T2c-d, N0, M0); (T3b-c, N0, M0); (T4a, N0, M0); IIIB (T3d, N0, M0); (T4b-c, N0, M0); IIIC: (T4d-e, N0, M0). T2c: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T2d: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T3b: Tumor size category 3 with ciliary body involvement. T3c: Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T4a: Tumor size category 4 without ciliary body involvement and extraocular extension. T3d: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter.  T4b: Tumor size category 4 with ciliary body involvement. T4c: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T4d: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T4e: Any tumor size category with extraocular extension more than 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Stage I Uveal Melanoma AJCC v7

description: Stage I includes: T1a, N0, M0.  T1a: Iris: Tumor limited to the iris not more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement and extraocular extension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Stage IIA Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IIA includes: (T1b-d, N0, M0); (T2a, N0, M0).  T1b: Tumor size category 1 with ciliary body involvement.  T1c: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter.  T1d: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T2a: Tumor size category 2 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


name: Stage I Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage I includes: T1a, N0, M0. T1a: Tumor size category 1 without ciliary body involvement and extraocular extension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 8th ed.)


name: Stage IV Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IV includes: (Any T, N1, M0); (Any T, Any N, M1a-c). N1: Regional lymph node metastasis or discrete tumor deposits in the orbit. M0: No distant metastasis. M1a: Distant metastasis, with the largest diameter of the largest metastasis measuring 3 cm or less. M1b: Distant metastasis, with the largest diameter of the largest metastasis measuring 3.1-8.0 cm. M1c: Distant metastasis, with the largest diameter of the largest metastasis measuring 8.1 cm or more.  (AJCC 8th ed.)


name: Ciliary Body Spindle Cell Type A Melanoma

description: A ciliary body melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Stage IIIB Uveal Melanoma AJCC v7

description: Stage IIIB includes: (T3d, N0, M0); (T4b-c, N0, M0).  T3d: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4b: Iris: Tumor with extrascleral extension more than 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 with ciliary body involvement.  T4c: Ciliary body and choroid: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Metastatic Uveal Melanoma

description: Uveal melanoma that has spread from its primary site to another anatomic site.


Iris Mixed Cell Melanoma

description: A melanoma arising from the iris. It is characterized by the presence of a mixture of spindle A melanoma cells, spindle B melanoma cells, and epithelioid melanoma cells.


Stage IV Uveal Melanoma AJCC v7

description: Stage IV includes: (Any T, N1, M0); (Any T, Any N, M1a-c).  N1: Regional lymph node metastasis. M1a: Distant metastasis, with the largest diameter of the largest metastasis measuring 3 cm or less.  M1b: Distant metastasis, with the largest diameter of the largest metastasis measuring 3.1-8.0 cm.  M1c: Distant metastasis, with the largest diameter of the largest metastasis measuring 8.0 cm or more.  (AJCC 7th ed.)


Benign neoplasm of uveal tract

description: A neoplasm that arises from the uvea and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential..


name: Stage IIIC Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IIIC includes: T4d-e, N0, M0. T4d: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T4e: Any tumor size category with extraocular extension more than 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


name: Metastatic Malignant Neoplasm in the Iris

description: A malignant neoplasm that has spread to the iris from another anatomic site.


name: Stage II Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage II includes: IIA (T1b-d, N0, M0); (T2a, N0, M0); IIB (T2b, N0, M0); (T3a, N0, M0).  T1b: Tumor size category 1 with ciliary body involvement.  T1c: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter.  T1d: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T2a: Tumor size category 2 without ciliary body involvement and extraocular extension. T2b: Tumor size category 2 with ciliary body involvement. T3a: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Uveal Melanoma by AJCC v7 Stage

description: A term that refers to the staging of uveal melanoma, following the rules of the TNM AJCC v7 classification system.


Uveal Spindle Cell Type B Melanoma

description: A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Uveal Class 1 Melanoma

description: Gene expression profiling that classifies uveal melanomas into a low-grade group.


Uveal Nevus

description: A benign nevus derived from melanocytes of the uveal tract. Only a small percentage of cases progress to uveal melanoma.


Advanced Uveal Melanoma

description: Uveal melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Iridociliary Melanoma

description: Melanoma that affects both the iris and ciliary body.


Iris Epithelioid Cell Melanoma

description: An iris melanoma characterized by the presence of malignant large epithelioid melanocytes.


name: Metastatic malignant neoplasm to ciliary body

description: A malignant neoplasm that has spread to the ciliary body from another anatomic site.


Conjunctival keratoacanthomas

description: A rapidly growing neoplasm that arises from the conjunctiva. It is characterized by a proliferation of squamous cells, acanthosis, keratinization, dysplasia, increased mitotic activity, and a central crater filled with keratinocytes. It is considered a variant of well-differentiated squamous cell carcinoma with distinct clinical behavior.


Conjunctival Spindle Cell Carcinoma

description: A variant of conjunctival squamous cell carcinoma characterized by the presence of malignant spindle cells and/or pleomorphic cells.


Stage II Fallopian Tube Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Fallopian Tube Cancer AJCC v8

description: Stage IIA includes: T2a, N0, M0. T2a: Fallopian tube cancer with extension and/or implants on the uterus and/or fallopian tube(s) and/or ovaries. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)