Penile Pseudohyperplastic Carcinoma

description: A multifocal, extremely differentiated squamous cell carcinoma of the penis. It typically occurs in older patients and is associated with lichen sclerosus.


Adult Penile Carcinoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A carcinoma of the penis that occurs during adulthood.


Penile Epithelioid Hemangioendothelioma

description: An epithelioid hemangioendothelioma that occurs in the penis.


Penile Leiomyoma

description: A leiomyoma that occurs in the penis.


Penile Soft Tissue Neoplasm

description: A rare mesenchymal neoplasm that arises from the penis.


Penile Pseudoglandular Carcinoma

description: A penile squamous cell carcinoma characterized by the formation of gland-like structures.


Stage 0 Penile Cancer AJCC v8

description: Stage 0 includes: 0is: Tis, N0, M0; 0a: Ta, N0, M0. Tis: Penile cancer with a finding of carcinoma in situ (penile intraepithelial neoplasia [PeIN]). Ta: Penile cancer with a finding of noninvasive localized squamous cell carcinoma. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIB Penile Cancer AJCC v8

description: Stage IIIB includes: T1-3, N2, M0. T1: Glans: Penile cancer with tumor invading lamina propria. Foreskin: Penile cancer with tumor invading dermis, lamina propria, or dartos fascia. Shaft: Penile cancer with tumor invading connective tissue between epidermis and corpora regardless of location. All sites with or without lymphovascular invasion or perineural invasion and is or is not high grade. T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N2: Penile cancer with three or more unilateral inguinal metastases or bilateral metastases. M0: No distant metastasis. (AJCC 8th ed.)


name: Human Papillomavirus-Related Penile Intraepithelial Neoplasia

description: Intraepithelial neoplasia of the penis caused by human papillomavirus infection.


name: Penile Malignant Peripheral Nerve Sheath Tumor

description: A rare malignant peripheral nerve sheath tumor that occurs in the penis.


Penile Papillary-Basaloid Carcinoma

description: A variant of penile basaloid squamous cell carcinoma. It is characterized by a papillary exophytic or endophytic growth pattern.


Stage 0a Penile Cancer AJCC v8

description: Stage 0a includes: Ta, N0, M0. Ta: Penile cancer with a finding of noninvasive localized squamous cell carcinoma. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Low Grade Penile Intraepithelial Neoplasia

description: Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy the lower one third of the epithelial thickness.


Penile Epithelioid Hemangioma

description: An epithelioid hemangioma that occurs in the skin of the penis.


name: High Grade Penile Intraepithelial Neoplasia

description: Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy either the lower two thirds of the epithelial thickness (grade II) or the entire thickness of the epithelium (grade III, Bowen atypia, or squamous cell carcinoma in situ).


Stage II Penile Cancer AJCC v8

description: Stage II includes: IIA: (T1b, N0, M0); (T2, N0, M0); IIB: (T3, N0, M0). T1b: Penile cancer with tumor exhibiting lymphovascular invasion and/or perineural invasion or is high grade (i.e., grade 3 or sarcomatoid). T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Penile Warty-Basaloid Carcinoma

description: A squamous cell carcinoma that arises from the penis. It is characterized by warty (condylomatous) and basaloid features.


Penile Angiosarcoma

description: A rare angiosarcoma that affects the penis.


name: Warty-Basaloid Penile Intraepithelial Neoplasia

description: Intraepithelial neoplasia of the penis characterized by the presence of a variable mixture of warty and basaloid cells. (WHO 2016)


melanoma of penis

description: A melanoma that arises from the penis. It may be cutaneous or mucosal. The most common site of involvement is glans penis.


Metastatic Penile Cancer

description: Carcinoma of the penis that has spread from its original site of growth to another anatomic site.


Stage I Penile Cancer AJCC v8

description: Stage I includes: T1a, N0, M0. T1a: Penile cancer with tumor without lymphovascular invasion or perineural invasion and is not high grade (i.e., grade 3 or sarcomatoid). N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Penile Mucoepidermoid Carcinoma

description: An extremely rare carcinoma that arises from the penis and is characterized by the presence of mucinous and squamous components.


Penile Rhabdomyosarcoma

description: A rhabdomyosarcoma that occurs in the penis. It usually affects young children. Embryonal rhabdomyosarcoma is the most common type.


Locally Advanced Penile Carcinoma

description: Penile carcinoma that has spread to nearby tissues or lymph nodes.


Current Hepatitis B Infection

description: Hepatitis B infection is evident at the time of testing.


Acute Intrapartum Hypoxic Event

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A sentinel hypoxic event occurring during labor, with evidence of fetal metabolic acidosis in the fetal umbilical arterial blood; a sudden and sustained fetal bradycardia or the absence of fetal heart rate variability in the presence of persistent, late, or variable decelerations (category III tracing); previously normal Apgar scores that are 0-3 beyond 5 minutes.


Stage IIIB Anal Cancer AJCC v8

description: Stage IIIB includes: T4, N0, M0. T4: Tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Postoperative Hemorrhage

description: Bleeding occurring after completion of a surgical procedure, which may occur immediately or may be delayed, and which may or may not be wound related.


name: Uterine Corpus Spindle Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle tumor of uncertain malignant potential that arises from the uterine corpus and is composed of neoplastic spindle cells.


description: A rare serous cystadenocarcinoma that arises from the paratesticular structures.


name: Fumarate Hydratase-Deficient Renal Cell Carcinoma

description: A rare, highly aggressive renal cell carcinoma caused by germline or (in a subset) somatic mutation of fumarate hydratase gene. It arises mostly in the setting of hereditary leiomyomatosis-renal cell carcinoma syndrome.


Acephalostomia

description: A congenital defect characterized by the absence of most or all of the head, with the presence of a mouth-like opening on the upper thorax.


A monounsaturated fatty aldehyde that is heptadecanal carrying a double bond at position 8.


Pancreatic Beta Cell Adenoma

description: An adenoma arising from the beta cells of the pancreas.  It produces insulin.


Carcinoma of lower gum

description: A carcinoma of the oral cavity that arises from the lower gingiva.


Carcinoma of upper gum

description: A carcinoma of the oral cavity that arises from the upper gingiva.


Gingival Spindle Cell Carcinoma

description: A poorly differentiated squamous cell carcinoma that arises from the gingiva. It is characterized by the presence of malignant pleomorphic spindle cells.


Gingival Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the gingival mucosa. It presents as an ulcerated lesion or exophytic mass. The prognosis is usually poor.


Gingival Angiofibroma

description: A benign neoplasm arising from the fibrous soft tissues of the gingiva. It is characterized by the presence of spindle-shaped fibroblasts and numerous dilated vascular channels.


squamous cell carcinoma of lower gum

description: A squamous cell carcinoma of the oral cavity that arises from the lower gingiva.


carcinoma of gingiva

description: A carcinoma of the oral cavity that arises from the upper or lower gingiva.


squamous cell carcinoma of upper gum

description: A squamous cell carcinoma of the oral cavity that arises from the upper gingiva.


name: Retromolar Trigone Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the retromolar trigone. Pain, often radiating to the ear, is the presenting symptom. The prognosis is poor.


name: Paranasal sinus teratocarcinosarcoma (type)

description: A malignant sinonasal neoplasm with combined histological features of teratoma and carcinosarcoma, lacking malignant germ cell components. (WHO 2017)


carcinosarcoma of salivary gland

description: An aggressive, high grade malignant tumor that arises from the salivary gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.


Lacrimal Gland Carcinosarcoma

description: An aggressive, high grade malignant neoplasm that arises from the lacrimal gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.


Pleomorphic adenoma of parotid gland

description: A benign, slow-growing tumor that arises from the parotid gland.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation. It is the most common neoplasm of salivary gland origin and women are more often affected than men.


name: Recurrent Childhood Anaplastic Oligoastrocytoma

description: The reemergence of anaplastic oligoastrocytoma in childhood after a period of remission.


name: Malignant Mixed Tumor of the Major Salivary Gland

description: A malignant tumor arising from the parotid gland, submandibular gland, or sublingual gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


Conjunctival Adenosquamous Carcinoma

description: A carcinoma that arises from the conjunctiva. It is characterized by the presence of a variable combination of squamous (epidermoid) cells and mucous cells, arranged in invasive sheets, cords, and ducts. (WHO 2018)


name: Stage III Uterine Corpus Adenosarcoma AJCC v8

description: Stage III includes: IIIA: T3a, N0, M0; IIIB: T3b, N0, M0; IIIC: T1-3, N1, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues. T3a: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at one site. T3b: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Adenocarcinoma with cartilaginous and osseous metaplasia

description: An invasive adenocarcinoma characterized by focal or extensive cartilage and/or bone formation.


Recurrent Anaplastic Oligoastrocytoma

description: The reemergence of anaplastic oligoastrocytoma after a period of remission.


Uterine Carcinosarcoma, Homologous Type

description: A carcinosarcoma of the uterus characterized by the presence of sarcomatous elements that arise from the tissues of the uterus.


name: Uterine Corpus Adenosarcoma by AJCC v8 Stage

description: A term that refers to the staging of uterine corpus adenosarcoma according to the American Joint Committee on Cancer, 8th edition.


name: Testicular Mixed Embryonal Carcinoma and Teratoma with Seminoma

description: A malignant mixed germ cell tumor arising from the testis.  It is characterized by the presence of a mixture of embryonal carcinoma, a teratomatous component, and a seminomatous component.


name: Metastatic Endometrial Adenosquamous Carcinoma

description: Endometrial adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


name: mixed acinar-endocrine carcinoma of pancreas

description: A carcinoma that arises from the pancreas and is composed of acinar carcinoma and neuroendocrine carcinoma components in both the primary tumor and the metastatic sites.


name: Benign Cervical Mixed Epithelial and Mesenchymal Neoplasm

description: A neoplasm that arises from the cervix and is characterized by the presence of benign epithelial and benign mesenchymal elements. This category includes adenofibroma and adenomyoma.


Primary peritoneal carcinosarcoma

description: An extremely rare and highly aggressive malignant neoplasm arising from the peritoneum.  Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements.


Hybrid Salivary Gland Tumor

description: A rare neoplasm that arises from the salivary gland and consists of at least two histologically distinct types of tumor within the same topographic location. The tumor components can be either benign or malignant.


name: Uterine Carcinosarcoma, Heterologous Type

description: A carcinosarcoma of the uterus characterized by the presence of sarcomatous elements composed of tissues that are not found in the uterus (e.g., bone, cartilage, skeletal muscle).


name: Appendix Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the appendix.  It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


name: Metastasizing Pleomorphic Adenoma of the Salivary Gland

description: A very rare pleomorphic adenoma of the salivary glands that metastasizes inexplicably, despite the benign histopathologic features.  The most common sites of metastasis are bone, lung, and head and neck.


Oropharyngeal Pleomorphic Adenoma

description: A pleomorphic adenoma that arises from the oropharynx.


name: Stage IIIA Uterine Corpus Adenosarcoma AJCC v8

description: Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Borderline Serous Cystadenofibroma

description: A neoplasm of low malignant potential arising from a site in the female reproductive system. Almost all cases have been reported in the ovary. It is characterized by the presence of cystic spaces which are lined by atypical serous epithelial cells. The surrounding ovarian stroma is fibrotic. There is no evidence of stromal invasion.


Advanced Uterine Corpus Carcinosarcoma

description: Uterine corpus carcinosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage IIIC Uterine Corpus Adenosarcoma AJCC v8

description: Stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Advanced Malignant Mixed Mesodermal (Mullerian) Tumor

description: A malignant mixed mesodermal (Mullerian) tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage I Uterine Corpus Adenosarcoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Metastatic Cervical Adenosquamous Carcinoma

description: A cervical adenosquamous carcinoma that has spread to another anatomic site.


name: Testicular Mixed Choriocarcinoma and Seminoma

description: A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of choriocarcinoma and seminomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


name: Metastatic Pancreatic Adenosquamous Carcinoma

description: Pancreatic adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


name: Skin Squamous Cell Carcinoma with Sarcomatoid Differentiation

description: A rare carcinoma of the skin characterized by the presence of squamous cell carcinomatous and sarcomatous components.


Sellar Mixed Germ Cell Tumor

description: A mixed germ cell tumor that arises from or adjacent to the sellar region.


Cellular Pleomorphic Adenoma

description: A pleomorphic adenoma with increased cellularity.


name: Metastatic Vaginal Adenosquamous Carcinoma

description: Vaginal adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


name: Anal Canal Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the anal canal.  It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Recurrent Childhood Oligoastrocytoma

description: The reemergence of oligoastrocytoma in childhood after a period of remission.


Hard Palate Pleomorphic Adenoma

description: A benign, slow-growing and painless neoplasm that arises from the minor salivary glands in the hard palate.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation.


carcinosarcoma of gallbladder

description: A carcinoma that arises from the gallbladder and it is characterized by the presence of a sarcomatous component.  The sarcomatous component may contain osteosarcoma, chondrosarcoma, or rhabdomyosarcoma elements.


name: Mixed neuroendocrine-non neuroendocrine neoplasm

description: A rare neoplasm that consists of neuroendocrine and non-neuroendocrine cellular components. At least 30% of either component should be present for the diagnosis to be made.


name: Metastatic Uterine Corpus Carcinosarcoma

description: Uterine corpus carcinosarcoma that has spread from its original site of growth to another anatomic site.


name: Pancreatic Mixed Ductal Adenocarcinoma-Neuroendocrine Tumor

description: A very rare mixed neuroendocrine non-neuroendocrine neoplasm that arises from the pancreas and is composed of ductal adenocarcinoma and a neuroendocrine tumor component.


name: Testicular Mixed Embryonal Carcinoma and Teratoma

description: A malignant mixed germ cell tumor arising from the testis, characterized by the presence of an embryonal carcinomatous component and a teratomatous component.


name: Gallbladder Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the gallbladder and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Sinonasal Pleomorphic Adenoma

description: A pleomorphic adenoma that arises from the sinonasal tract.


Metastatic Carcinosarcoma

description: Carcinosarcoma that has spread from its original site of growth to another anatomic site.


Recurrent Fallopian Tube Carcinosarcoma

description: The reemergence of fallopian tube carcinosarcoma after a period of remission.


Hybrid Salivary Gland Carcinoma

description: A rare carcinoma that arises from the salivary gland and consists of at least two histologically distinct types of carcinoma within the same topographic location. The carcinoma components usually are adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, and/or salivary duct carcinoma. Adenoid cystic carcinoma is commonly the predominant component.


Adult Mixed Glioma

description: A mixed glioma that occurs during adulthood.


Malignant chondroid syringoma

description: A rare malignant skin neoplasm that arises from a benign mixed tumor of the skin (chondroid syringoma).


Uterine Ligament Adenomyoma

description: A benign neoplasm that arises from the broad or other uterine ligaments. It is characterized by the presence of a glandular and a mesenchymal component.


name: Testicular Mixed Choriocarcinoma and Embryonal Carcinoma

description: A malignant mixed germ cell tumor that arises from the testis and is characterized by the presence of choriocarcinoma and embryonal carcinoma morphologic components.


name: Stage IIIB Uterine Corpus Adenosarcoma AJCC v8

description: Stage IIIB includes: T3b, N0, M0. T3b: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Mixed parotid tumor

description: A benign or malignant neoplasm that arises from the parotid gland.  It is characterized by the presence of epithelial and mesenchymal elements.  This category includes pleomorphic adenoma, carcinoma ex pleomorphic adenoma, and carcinosarcoma.


name: Testicular Mixed Teratoma and Yolk Sac Tumor, Prepubertal-Type

description: A very rare testicular germ cell tumor that combines teratoma and yolk sac tumor. It usually affects young children. It is not associated with chromosome 12p amplification or germ cell neoplasia in situ.


Childhood Oligoastrocytoma

description: An oligoastrocytoma that occurs during childhood.


name: Gastric Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the stomach and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


name: Minor Salivary Gland Carcinoma ex Pleomorphic Adenoma

description: A carcinoma that arises from a pleomorphic adenoma in the minor salivary glands.  Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months.  Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis.  In cases where there is invasion of the surrounding tissues, the clinical course is aggressive.


Oral Cavity Pleomorphic Adenoma

description: A benign, slow-growing and painless neoplasm that arises from the salivary glands in the oral cavity.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation.


name: Stage IA Uterine Corpus Adenosarcoma AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Uterine corpus adenosarcoma with tumor limited to the endometrium/endocervix. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Testicular Mixed Choriocarcinoma and Yolk Sac Tumor

description: A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of choriocarcinoma and yolk sac tumor morphologic elements.  Patients may present with painless or painful testicular swelling.


Recurrent Oligoastrocytoma

description: The reemergence of oligoastrocytoma after a period of remission.


name: Pancreatic Mixed Ductal-Neuroendocrine Neoplasm

description: A rare mixed neuroendocrine non-neuroendocrine neoplasm that arises from the pancreas and is composed of ductal adenocarcinoma and a neuroendocrine neoplastic component. The latter is usually a poorly differentiated neuroendocrine carcinoma and rarely a well differentiated neuroendocrine tumor.


name: Testicular Mixed Yolk Sac Tumor and Teratoma

description: A malignant non-seminomatous germ cell tumor arising from the testis.  It is characterized by a mixture of yolk sac and teratomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


name: Malignant Submandibular Gland Mixed Tumor

description: A malignant tumor arising from the submandibular gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


name: Benign Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm

description: A non-metastasizing neoplasm that arises from the uterine corpus and is composed of epithelial and mesenchymal elements. Representative examples include adenomyoma and adenofibroma.


name: Testicular Mixed Yolk Sac Tumor and Teratoma with Seminoma

description: A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of yolk sac, teratomatous, and seminomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


Mixed Carcinoma

description: A carcinoma characterized by the presence of more than one malignant epithelial histologic pattern.


name: Stage IVB Uterine Corpus Adenosarcoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


name: Recurrent Cervical Adenosquamous Carcinoma

description: The reemergence of cervical adenosquamous carcinoma after a period of remission.


name: Stage IB Uterine Corpus Adenosarcoma AJCC v8

description: Stage IB includes: T1b, N0, M0. T1b: Uterine corpus adenosarcoma with tumor invading to less than half of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Recurrent Primary Peritoneal Carcinosarcoma

description: The reemergence of primary peritoneal carcinosarcoma after a period of remission.


name: Malignant Mixed Tumor, Not Otherwise Specified

description: A malignant myoepithelioma characterized by the presence of a minor ductal component.


Childhood Anaplastic Oligoastrocytoma

description: An anaplastic oligoastrocytoma that occurs during childhood.


Childhood Breast Fibroadenoma

description: A fibroadenoma that arises from the breast and occurs during childhood.


name: Ampulla of Vater Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the ampulla of Vater and the periampullary region. It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Childhood Mixed Glioma

description: A mixed glioma that occurs during childhood.


name: Stage II Uterine Corpus Adenosarcoma AJCC v8

description: Stage II includes: T2, N0, M0. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


adenosquamous carcinoma of tongue

description: A rare adenosquamous carcinoma that arises from the tongue.


name: Testicular Mixed Embryonal Carcinoma and Seminoma

description: A malignant mixed germ cell tumor arising from the testis.  It is characterized by the presence of a mixture of embryonal carcinoma and a seminomatous component.


name: Refractory Uterine Corpus Carcinosarcoma

description: Uterine Corpus Carcinosarcoma that is resistant to treatment.


Advanced Carcinosarcoma

description: Carcinosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Choriocarcinoma combined with other germ cell elements

description: A malignant mixed germ cell tumor characterized by the presence of a choriocarcinomatous component admixed with another germ cell component (e.g. embryonal carcinoma, teratoma, or seminoma).


name: Recurrent Endometrial Adenosquamous Carcinoma

description: The reemergence of endometrial adenosquamous carcinoma after a period of remission.


name: Malignant Vaginal Mixed Tumor Resembling Synovial Sarcoma

description: A very rare malignant mixed epithelial and mesenchymal neoplasm that arises from the vagina and resembles synovial sarcoma.  It is characterized by a biphasic pattern and is composed of gland-like structures that are lined by epithelial cells and a cellular mesenchymal component.


Malignant Parotid Gland Mixed Tumor

description: A malignant tumor arising from the parotid gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


Odontogenic Carcinosarcoma

description: An extremely rare malignant mixed odontogenic neoplasm in which both the epithelial and the mesenchymal components are cytologically malignant. (WHO 2017)


name: Advanced Pancreatic Adenosquamous Carcinoma

description: Pancreatic adenosquamous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Invasive Bladder Mixed Carcinoma

description: An invasive bladder carcinoma characterized by the presence of more than one histologic pattern.


name: Human Papillomavirus-Related Adenosquamous Carcinoma

description: An adenosquamous carcinoma associated with the presence of human papillomavirus infection.


name: Esophageal Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the esophagus and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Vaginal Adenosquamous Carcinoma

description: A carcinoma that arises from the vagina and is characterized by the presence of malignant glandular and malignant squamous epithelial components.


Laryngeal Pleomorphic Adenoma

description: A very rare pleomorphic adenoma that arises from the larynx.


name: Stage IVA Uterine Corpus Adenosarcoma AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Uterine corpus adenosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. (from AJCC 8th Ed.)


Mixed Tumor, Not Otherwise Specified

description: A benign myoepithelioma characterized by the presence of a minor ductal component.


name: Vulvar Composite Hidradenoma Papilliferum and Fibroadenoma

description: A benign composite neoplasm that arises from the vulva and is characterized by mixed histopathologic features of hidradenoma papilliferum and fibroadenoma.


name: Testicular Mixed Embryonal Carcinoma and Yolk Sac Tumor

description: A malignant non-seminomatous germ cell tumor arising from the testis.  It is characterized by a mixture of embryonal carcinoma and yolk sac morphologic elements.  Patients may present with painless or painful testicular swelling.


name: Pancreatic Mixed Acinar-Ductal Neuroendocrine Carcinoma

description: A very rare carcinoma that arises from the pancreas and is composed of ductal adenocarcinoma, acinar carcinoma, and neuroendocrine carcinoma components.


Trichoblastic carcinosarcoma

description: A rare biphasic follicular neoplasm consisting of a malignant epithelial component resembling follicular germinative cells closely associated with a malignant stromal component differentiating towards specific follicular mesenchyme. (WHO 2018)


name: Metastatic Digestive System Mixed Adenoneuroendocrine Carcinoma

description: Mixed adenoneuroendocrine carcinoma that arises from the digestive system and has metastasized to other anatomic sites.


Hybrid nerve sheath tumor

description: A benign nerve sheath tumor characterized by the combination of histologic features seen in schwannomas, neurofibromas, and perineuriomas.


Pleomorphic adenoma of lacrimal gland

description: A benign, usually encapsulated neoplasm of the lacrimal gland composed of epithelial and mesenchymal cells.  Pleomorphic adenomas are neoplasms that develop in the salivary glands or heterotopic salivary gland tissues.  It has been suggested that myoepithelial cells play a major role in the histogenesis of these tumors.  In the lacrimal gland, pleomorphic adenomas presumably develop from metaplastic myoepithelial cells.


name: Malignant Mixed Tumor of the Minor Salivary Gland

description: A malignant tumor arising from the minor salivary glands.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


name: Seminal Vesicle Mixed Epithelial and Stromal Tumor

description: A rare biphasic neoplasm that arises from the seminal vesicle. It is characterized by the presence of stromal and benign epithelial components. Rarely, the stromal component may display atypia and mitotic activity and the tumor may behave in a malignant clinical course.


Soft Palate Pleomorphic Adenoma

description: A benign, slow-growing and painless neoplasm that arises from the minor salivary glands in the soft palate.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation.


Breast Pleomorphic Adenoma

description: A rare, benign and well circumscribed neoplasm that arises from the breast.  It is characterized by the proliferation of epithelial and myoepithelial cells surrounded by chondroid stroma.


name: Stage IC Uterine Corpus Adenosarcoma AJCC v8

description: Stage IC includes: T1c, N0, M0. T1c: Uterine corpus adenosarcoma with tumor invading more than half of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Stage IV Uterine Corpus Adenosarcoma AJCC v8

description: Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus adenosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


name: Metastatic Malignant Mixed Mesodermal (Mullerian) Tumor

description: A malignant mixed mesodermal (Mullerian) tumor that has spread from its original site of growth to another anatomic site.


Recurrent Uterine Corpus Carcinosarcoma

description: The reemergence of uterine corpus carcinosarcoma after a period of remission.


Parotid Gland Carcinosarcoma

description: An aggressive, high grade malignant tumor that arises from the parotid gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.


name: Gallbladder Mucinous Cystic Neoplasm, High Grade

description: A non-invasive mucinous cystic neoplasm that arises from the gallbladder epithelium.  It is characterized by the presence of severe atypia.


name: Adenocarcinoma of anogenital mammary-like glands

description: A primary invasive malignant epithelial neoplasm of the vulva showing morphological features of recognized breast adenocarcinomas. (WHO, 2014)


Vulvar Adenocarcinoma, Intestinal-Type

description: A rare vulvar mucinous adenocarcinoma that resembles a large intestinal adenocarcinoma.


A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.


name: epilepsy, juvenile myoclonic, susceptibility to, 9


Cervical Squamotransitional Carcinoma

description: A human papillomavirus-related cervical squamous cell carcinoma characterized by the presence of papillary structures with fibrovascular cores. It is covered with multiple layers of atypical cells that resemble cervical intraepithelial neoplasia 3.


Transformed migraine

description: Episodes of migraine occurring on 15 or more days per month, for more than three months.


description: A reactive proliferation of the conjunctival epithelium associated with the presence of prominent glandular elements.


Spinal arthritis deformans

description: Degenerative arthritis of the spinal column.


Spastic Paraplegia 30

description: An autosomal recessive subtype of hereditary spastic paraplegia caused by mutation(s) in the KIF1A gene, encoding kinesin-like protein KIF1A.


Amyotrophic Lateral Sclerosis 25

description: An autosomal dominant form of amyotrophic lateral sclerosis caused by mutation(s) in the KIF5A gene, encoding kinesin heavy chain isoform 5A.


Spastic Paraplegia 76

description: An autosomal recessive subtype of hereditary spastic paraplegia caused by mutation(s) in the CAPN1 gene, encoding calpain-1 catalytic subunit.


name: Neurodegeneration with Brain Iron Accumulation 2A

description: An autosomal recessive condition caused by mutation(s) in the PLA2G6 gene, encoding 85/88 kDa calcium-independent phospholipase A2. It is characterized by axonal swelling and spheroid bodies in the central nervous system. The onset is typically in the first two years of life.


name: Unresectable Pancreatic Neuroendocrine Tumor G3

description: Pancreatic neuroendocrine tumor G3 that is not amenable to surgical resection.


name: Adult Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB-MYH11

description: An acute myeloid leukemia with inv(16)(p13.1q22); CBFB-MYH11 occurring in adults.


Moniliform hamartoma

description: A type of pilosebaceous hamartoma characterized by the development of a linear, flesh colored, fine papular eruption on the head, neck and upper chest after puberty.


Apocrine Sweat Gland Hamartoma

description: A hamartoma characterized by localized apocrine sweat gland malformation.


name: Recurrent Endometrial Undifferentiated Carcinoma

description: The reemergence of endometrial undifferentiated carcinoma after a period of remission.


name: Metastatic Endometrial Undifferentiated Carcinoma

description: Endometrial undifferentiated carcinoma that has spread from its original site of growth to another anatomic site.


name: Refractory Endometrial Undifferentiated Carcinoma

description: Endometrial undifferentiated carcinoma that is resistant to treatment.


name: Esophageal Gastrointestinal Stromal Tumor

description: A gastrointestinal stromal tumor that arises from the esophagus.  The majority are spindle cell tumors that exhibit high mitotic activity and affect the distal esophagus.


name: Stage IVB Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Oral cavity cancer with very advanced local disease.  Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IVB Lip and Oral Cavity Cancer AJCC v6 and v7

description: Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Lip and oral cavity cancer with very advanced local disease.  Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IVB Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7


name: Stage IVB Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7


name: Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Lip and oral cavity cancer with very advanced local disease. Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IVB Oral Cavity Cancer AJCC v6 and v7


Stage IVB Lip Cancer AJCC v6 and v7

description: Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Lip cancer with very advanced local disease.  Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Pathologic Stage IB Cutaneous Melanoma AJCC v8

description: Stage IB includes: T2a, N0, M0. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Vein of Galen Malformations

description: An arteriovenous malformation in the vein of Galen that is located at the base of the brain. The malformation may result in developmental delays, hydrocephalus, seizures, and congestive heart failure.


name: Dextro-Transposition of the Great Vessels with Ventricular Septal Defect

description: A congenital heart defect in which there is an abnormal arrangement of any of the primary blood vessels of the heart in conjunction with a pathologic opening between the cardiac ventricles.


Stage II Low-CSD Melanoma AJCC v7

description: Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0).  T2b: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, with ulceration.  T3a: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, without ulceration.  T3b: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, with ulceration.  T4a: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, without ulceration.  T4b: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Ed.)


name: Stage II Cutaneous Melanoma AJCC v6 and v7

description: Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0).  T2b: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, with ulceration.  T3a: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, without ulceration.  T3b: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, with ulceration.  T4a: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, without ulceration.  T4b: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


name: Stage II Lentigo Maligna Melanoma AJCC v6 and v7


name: Stage IIC Cutaneous Melanoma AJCC v6 and v7

description: Stage IIC includes: T4b, N0, M0.  T4b: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


name: Stage IIB Cutaneous Melanoma AJCC v6 and v7

description: Stage IIB includes: (T3b, N0, M0); (T4a, N0, M0).  T3b: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, with ulceration.  T4a: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


name: Stage IIA Cutaneous Melanoma AJCC v6 and v7

description: Stage IIA includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, with ulceration.  T3a: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


Atypical Vascular Proliferation

description: Benign vascular proliferations following external radiation. The lesions present in adults, predominantly in elderly women following radiotherapy for breast carcinoma. They arise from the radiated skin and are papules, small vesicles, or erythematous ecchymotic plaques with prominent telangiectasias. Identical lesions can occur after radiation for cervical carcinoma, endometrial carcinoma, ovarian carcinoma, Hodgkin lymphoma, and melanoma. There is an increased risk for subsequent development of angiosarcoma.


Atypical Vascular Lesion of Breast

description: Benign vascular proliferations following external radiation for breast carcinoma. The lesions arise from the radiated skin and are papules, small vesicles, or erythematous ecchymotic plaques with prominent telangiectasias. There is an increased risk for subsequent development of angiosarcoma.


name: Advanced Digestive System Neuroendocrine Tumor G3

description: Digestive system neuroendocrine tumor G3 that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Bladder squamous cell carcinoma recurrent

description: The reemergence of bladder squamous cell carcinoma after a period of remission.


Bladder cancer recurrent

description: The reemergence of bladder carcinoma after a period of remission.


name: Recurrent Non-Muscle Invasive Bladder Carcinoma

description: The reemergence of non-muscle invasive bladder carcinoma after a period of remission.


name: Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma

description: The reemergence of non-muscle invasive bladder urothelial carcinoma after a period of remission.


name: Recurrent Muscle Invasive Bladder Urothelial Carcinoma

description: The reemergence of muscle invasive bladder urothelial carcinoma after a period of remission.


name: Recurrent Bladder Small Cell Neuroendocrine Carcinoma

description: The reemergence of bladder small cell neuroendocrine carcinoma after a period of remission.


Bladder adenocarcinoma recurrent

description: A recurrence of adenocarcinoma of the bladder after a period of remission.


Urothelial carcinoma bladder recurrent

description: The reemergence of bladder urothelial carcinoma after a period of remission.


name: PERSISTENT MULLERIAN DUCT SYNDROME, TYPE II

description: Persistent Mullerian duct syndrome due to resistance to anti-Mullerian hormone (AMH), resulting from mutations in the AMH receptor (AMHR) gene.


Stage IV Paranasal Sinus Cancer AJCC v7

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


name: Sinonasal Adenocarcinoma, Intestinal-Type with Papillary Pattern

description: An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a papillary growth pattern.


name: Stage IVA Lip and Oral Cavity Cancer AJCC v8

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a (lip): Tumor invades through cortical bone or involves the inferior alveolar nerve, floor of mouth, or skin of face (i.e., chin or nose).  T4a (oral cavity): Tumor invades adjacent structures only (e.g., through cortical bone of the mandible or maxilla, or involves the maxillary sinus or skin of face). Note: Superficial erosion of bone/tooth socket (alone) by a gingival primary is not sufficient to classify a tumor as T4. T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less DOI. T2: Tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI. T3: Tumor size greater than 4 cm or any tumor greater than 10 mm DOI. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or larger than 3 cm but not larger than 6 cm in greatest dimension and ENE (-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension, ENE(-). M0: No distant metastasis. (AJCC 8th Ed.)


name: Metastatic Salivary Gland Squamous Cell Carcinoma

description: Salivary gland squamous cell carcinoma that has spread from the original site of growth to another anatomic site.


name: Recurrent Sinonasal Squamous Cell Carcinoma

description: The reemergence of nasal cavity and paranasal sinus squamous cell carcinoma after a period of remission.


name: Adenoid cystic carcinoma of the oral cavity stage II

description: Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Locally Advanced Oral Cavity Squamous Cell Carcinoma

description: Oral cavity squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IVC Lip Cancer AJCC v6 and v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


name: Lip and Oral Cavity Cancer by AJCC v6 and v7 Stage

description: A term that refers to the staging of lip and oral cavity carcinoma according to the American Joint Committee on Cancer, 6th and 7th editions.


name: Cutaneous Squamous Cell Carcinoma of the Head and Neck by AJCC v8 Stage

description: A term that refers to the staging of cutaneous squamous cell carcinoma of the head and neck according to the American Joint Committee on Cancer, 8th edition.


Lip basal cell carcinoma

description: A basal cell carcinoma arising from the lip.


Unresectable Head and Neck Carcinoma

description: Carcinoma that arises from the head and neck region and is not amenable to surgical resection.


name: Stage IVB Nasal Cavity and Paranasal Sinus Cancer AJCC v7

description: Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


name: Locally Recurrent Head and Neck Squamous Cell Carcinoma

description: The reemergence of head and neck squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


name: Sinonasal Spindle Cell Squamous Cell Carcinoma

description: A poorly differentiated squamous cell carcinoma arising from the sinonasal tract. It is characterized by the presence of malignant cells with spindle cell features.


name: Lower Alveolar Ridge Squamous Cell Carcinoma

description: Squamous cell carcinoma arising from the lower alveolar ridge.


name: Stage I Nasal Cavity Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1:Tumor restricted to any one subsite, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


SMARCB1-Deficient Sinonasal Carcinoma

description: An SWI/SNF-deficient sinonasal carcinoma characterized by biallelic deletion or inactivating mutation of SMARCB1 gene. It usually affects the paranasal sinuses, especially ethmoid. It is composed of a monomorphic malignant epithelial cellular population with a predominantly basaloid or plasmacytoid/rhabdoid morphology.


name: External Auditory Canal Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the keratinizing squamous epithelium that lines the external auditory canal.


Salivary Gland Secretory Carcinoma

description: A rare, low-grade carcinoma of the salivary gland with favorable clinical outcome.  It usually arises from the parotid gland and less often from the minor salivary glands.  It shares the same histopathologic features and molecular characteristics (ETV6 gene rearrangement) with secretory breast carcinoma.


name: Sinonasal Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that arises from the nasal cavity and paranasal sinuses.


Hard Palate Adenoid Cystic Carcinoma

description: An adenoid cystic carcinoma arising from the minor salivary glands in the hard palate.


description: An adenocarcinoma that arises from the nasal cavity and paranasal sinuses. Histologically it resembles intestinal adenocarcinoma. It is associated with lengthy occupational exposure to dust.


name: Ameloblastic Carcinoma Derived From Odontogenic Cyst

description: A rare, aggressive malignant tumor that originates from an odontogenic cyst in the maxillomandibular region.  It combines the histologic features of an ameloblastoma and carcinoma.


description: Adenocarcinomas that arise from the nasal cavity and paranasal sinuses and do not resemble salivary gland adenocarcinomas. This category includes intestinal-type and non-intestinal type adenocarcinomas.


Recurrent Lip and Oral Cavity Carcinoma

description: The reemergence of lip and/or oral cavity carcinoma after a period of remission.


Metastatic Salivary Gland Carcinoma

description: A salivary gland carcinoma that has metastasized to another anatomic site.


name: Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor 4 cm or larger in greatest dimension or minor bone erosion or perineural invasion or deep invasion. Deep invasion is defined as invasion beyond the subcutaneous fat or larger than 6 mm; perineural invasion for T3 classification is defined as tumor cells within the nerve sheath of a nerve lying deeper than the dermis or measuring 0.1 mm or larger in caliber, or presenting with clinical or radiographic involvement of named nerves without skull base invasion or transgression. T1: Tumor smaller than 2 cm in greatest dimension.  T2: Tumor 2 cm or larger, but smaller than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


Carcinoma of base of tongue

description: A carcinoma that arises from the base of the tongue.  Representative examples include squamous cell carcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.


name: Stage I Sinonasal Squamous Cell Carcinoma AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage IV Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose. T4a (oral cavity): Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face). T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension. N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension. N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Head and Neck Merkel Cell Carcinoma

description: Merkel cell carcinoma that arises from the head and neck region. It usually arises from sun-exposed skin. Rare cases arising from the oral cavity and salivary glands have been reported.


name: Paranasal Sinus Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the paranasal sinuses.


name: Paranasal Sinus Small Cell Neuroendocrine Carcinoma

description: A small cell neuroendocrine carcinoma that arises from the paranasal sinuses.


name: Primary Intraosseous Squamous Cell Carcinoma Derived From Keratocystic Odontogenic Tumor

description: A rare primary intraosseous carcinoma, not otherwise specified, that arises from the lining of an odontogenic keratocyst.


name: Head and Neck Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that arises from the head and neck.


name: Upper Alveolar Ridge Squamous Cell Carcinoma

description: Squamous cell carcinoma arising from the upper alveolar ridge.


Advanced Head and Neck Carcinoma

description: A head and neck carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Posterior Tongue Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the base of the tongue.  It usually presents as a painful ulcerated lesion.


name: Sinonasal Human Papillomavirus-Related Carcinoma with Adenoid Cystic-Like Features

description: A distinctive HPV-related non-keratinizing squamous cell carcinoma of the sinonasal tract arising most frequently from the maxillary sinus or nasal cavity. Most patients present with nasal obstruction and/or epistaxis. It is characterized by the presence of basaloid cell proliferations separated by collagenous fibrous bands. The basaloid cells align around microcystic spaces.


name: Stage 0 Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Anterior Tongue Adenoid Cystic Carcinoma

description: An adenoid cystic carcinoma arising from the minor salivary glands in the anterior tongue.


name: Unresectable Oral Cavity Squamous Cell Carcinoma

description: Oral cavity squamous cell carcinoma that is not amenable to surgical resection.


name: Squamous cell carcinoma of head and neck metastatic

description: A head and neck squamous cell carcinoma which has spread from the original site of growth to another anatomic site.


name: Stage IV Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a: (oral cavity) Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face).  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal NUT Carcinoma

description: A highly aggressive, poorly differentiated carcinoma that arises from the nasal cavity and paranasal sinuses. It is characterized by mutations and rearrangement of the NUT gene.


Sclerosing Odontogenic Carcinoma

description: A rare, low-grade primary intraosseous carcinoma of the jaws, with bland cytology, markedly sclerotic stroma, and aggressive infiltration. It is characterized by single-file thin cords, nests, and strands of epithelium in a densely sclerotic stroma. Cytologically, individual epithelial cells are bland, with infrequent mitoses. Their cytoplasm may show vacuolation or partial clearing. There is no squamous differentiation. Despite the benign appearance, there is invasion of skeletal muscle, and perineural infiltration is characteristic. (WHO 2017)


name: Sinonasal Poorly Differentiated Carcinoma

description: A poorly differentiated carcinoma that arises from the nasal cavity and/or paranasal sinuses.


name: Stage IVA Oral Cavity Cancer AJCC v6 and v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease.  Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


name: Adenoid cystic carcinoma of the oral cavity stage III

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Salivary Gland Low Grade Adenocarcinoma, Not Otherwise Specified

description: A salivary gland adenocarcinoma, not otherwise specified, characterized by the presence of low-grade morphological features.


name: Metastatic Oral Cavity Squamous Cell Carcinoma

description: A squamous cell carcinoma of the oral cavity which has spread from the original site of growth to another anatomic site.


Sinonasal Cancer by AJCC v8 Stage

description: A term that refers to the staging of nasal cavity and paranasal sinus carcinoma according to the American Joint Committee on Cancer, 8th edition.


Metastatic Oral Cavity Carcinoma

description: A carcinoma that arises from the oral cavity and has metastasized to another anatomic site.


Ghost Cell Odontogenic Carcinoma

description: A carcinoma usually arising from the maxilla and less often the mandible.  Symptoms include swelling and paresthesia.  It is characterized by the presence of rounded islands of malignant epithelial cells in a fibrous stroma and the benign features of calcifying cystic odontogenic tumor.  The clinical course varies from slow growing and locally invasive to rapidly growing and highly aggressive with metastases.


name: Minor Salivary Gland Small Cell Neuroendocrine Carcinoma

description: An infrequent small cell carcinoma that arises from a minor salivary gland. It is characterized by the presence of neuroendocrine differentiation and a high number of mitotic figures.


Recurrent Salivary Gland Cancer

description: The reemergence of salivary gland carcinoma after a period of remission.


name: Stage IVC Nasal Cavity and Paranasal Sinus Cancer AJCC v7

description: Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


Metastatic Lip Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the lip and has metastasized to another anatomic site.


Advanced Salivary Gland Carcinoma

description: Salivary gland carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Locally Advanced Paranasal Sinus Carcinoma

description: Paranasal sinus carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage IVA Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7


name: Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck

description: Cutaneous squamous cell carcinoma of the head and neck that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage 0 Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Locally Advanced Head and Neck Squamous Cell Carcinoma

description: A head and neck squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Paranasal Sinus Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the paranasal sinuses and is characterized by prominent production of keratin.


name: Platinum-Resistant Head and Neck Carcinoma

description: Head and neck carcinoma that is resistant to platinum therapy.


name: Salivary Gland Intestinal-Type Adenocarcinoma

description: An invasive adenocarcinoma that arises from the salivary gland. Morphologically, it is characterized by the presence of intestinal-type malignant epithelial cells.


name: Stage III Nasal Cavity Cancer AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Tumor restricted to any one subsite, with or without bony invasion.  T2: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Metastatic Lip and Oral Cavity Carcinoma

description: A carcinoma that arises from the lip and/or oral cavity and has metastasized to another anatomic site.


name: Recurrent Lip and Oral Cavity Squamous Cell Carcinoma

description: The reemergence of lip and oral cavity squamous cell carcinoma after a period of remission.


Low Grade Salivary Gland Carcinoma

description: A salivary gland carcinoma with low-grade histopathologic features.  It includes the salivary gland polymorphous low grade adenocarcinoma, salivary gland low grade cribriform cystadenocarcinoma, and low grade salivary gland mucoepidermoid carcinoma.  It usually follows a non-aggressive clinical course.


name: Stage IVB Lip and Oral Cavity Cancer AJCC v8

description: Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases the internal carotid artery. N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE (-); or in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral or bilateral lymph nodes any with ENE(+). M0: No distant metastasis. (AJCC 8th Ed.)


name: Head and Neck Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the head and neck region and is characterized by prominent production of keratin.


Unresectable Salivary Gland Carcinoma

description: Salivary gland carcinoma that is not amenable to surgical resection.


name: Stage IVC Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


name: Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease.  Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IVC Sinonasal Squamous Cell Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


Metastatic Sinonasal Carcinoma

description: Sinonasal carcinoma that has spread from its original site of growth to another anatomic site.


name: Low Grade Salivary Gland Mucoepidermoid Carcinoma

description: A salivary gland mucoepidermoid carcinoma with low-grade histopathologic features. It usually follows a non-aggressive clinical course.


Recurrent Lip Basal Cell Carcinoma

description: Reemergence of basal cell carcinoma of the lip after a period of remission.


name: Salivary Gland Polymorphous Adenocarcinoma, Cribriform Subtype

description: A salivary gland polymorphous adenocarcinoma characterized by the presence of malignant cells forming cribriform and multinodular patterns.


name: Locally Advanced Lip and Oral Cavity Carcinoma

description: Lip and oral cavity carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage IV Sinonasal Squamous Cell Carcinoma AJCC v7

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


name: Metastatic Paranasal Sinus Squamous Cell Carcinoma

description: Paranasal sinus squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


name: Stage II Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage II Sinonasal Squamous Cell Carcinoma AJCC v6 and v7

description: Stage II includes: T2, N0, M0.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th ed.)


name: Minor Salivary Gland Acinic Cell Carcinoma

description: An adenocarcinoma with serous acinar cell differentiation that arises from the minor salivary glands.


name: Stage II Nasal Cavity Cancer AJCC v6 and v7

description: Stage II includes: T2, N0, M0.  T2: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Head and Neck Heterotopia-Associated Carcinoma

description: A head and neck carcinoma arising from heterotopic tissue elements (i.e. histologically normal tissue of a particular type that is present at an abnormal anatomical site). (WHO 2017)


name: Stage II Oral Cavity Cancer AJCC v6 and v7

description: Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Recurrent Salivary Gland Mucoepidermoid Carcinoma

description: The reemergence of salivary gland mucoepidermoid carcinoma after a period of remission.


name: Stage 0 Lip and Oral Cavity Cancer AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Ameloblastic Carcinoma-Secondary Type (Dedifferentiated), Intraosseous

description: A very rare ameloblastic carcinoma that originates from a pre-existing intraosseous benign ameloblastoma.


name: Paranasal Sinus Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that arises from the paranasal sinuses.


name: SWI/SNF Complex-Deficient Sinonasal Carcinoma

description: A highly aggressive, poorly to undifferentiated carcinoma that arises from the sinonasal tract. It is characterized by loss of one SWI/SNF complex subunit (either SMARCB1 or SMARCA4) and lacks histological features to allow classification into another specific entity. Most patients present with locally advanced disease.


Head and neck cancer metastatic

description: A carcinoma that arises from the head and neck and has spread from the original site of growth to another anatomic site.


name: Locally Advanced Paranasal Sinus Squamous Cell Carcinoma

description: Paranasal sinus squamous cell carcinoma that has spread to nearby tissues or lymph nodes.


Locally Advanced Sinonasal Carcinoma

description: Sinonasal carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck

description: The reemergence of cutaneous squamous cell carcinoma of the head and neck after a period of remission.


name: Stage I Lip and Oral Cavity Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal Adenocarcinoma

description: Adenocarcinomas that arises from the sinonasal tract. This category includes salivary-type and non-salivary type adenocarcinomas. The latter includes intestinal-type and non-intestinal-type adenocarcinomas.


name: Stage IVA Sinonasal Squamous Cell Carcinoma AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Posterior Tongue Adenoid Cystic Carcinoma

description: An adenoid cystic carcinoma arising from the minor salivary glands in the base of the tongue.


name: Metastatic Salivary Gland Secretory Carcinoma

description: A salivary gland secretory carcinoma that has spread from its original site of growth to other anatomic sites.


name: Stage IVC Oral Cavity Cancer AJCC v6 and v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


adenocarcinoma of oral cavity

description: An adenocarcinoma that arises from the oral cavity.


Sinonasal Adenocarcinoma, Salivary-Type

description: Adenocarcinomas that arise from the seromucinous glands and surface epithelium of the nasal cavity and paranasal sinuses. These adenocarcinomas morphologically resemble the adenocarcinomas that arise from the major and minor salivary glands.


name: Stage IVA Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease.  Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Hard Palate Mucoepidermoid Carcinoma

description: A mucoepidermoid carcinoma arising from the minor salivary glands in the hard palate.


name: Stage II Lip and Oral Cavity Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th Ed.)


name: Locally Advanced Salivary Gland Carcinoma

description: A salivary gland carcinoma that has spread to nearby tissues or lymph nodes.


name: Tracheal Basaloid Squamous Cell Carcinoma

description: A high-grade, aggressive variant of squamous cell carcinoma that arises from the trachea. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading.


Adult Salivary Gland Carcinoma

description: A carcinoma of the salivary gland that occurs during adulthood.


name: Stage IV Nasal Cavity and Paranasal Sinus Cancer AJCC v6

description: Stage IV maxillary sinus cancer: Stage IV is divided into stages IVA, IVB, and IVC.  Stage IVA: cancer has spread to either one lymph node on the same side of the neck as the cancer and the lymph node is larger than 3 centimeters but smaller than 6 centimeters; or, cancer has spread to more than one lymph node anywhere in the neck, and all are 6 centimeters or smaller; cancer is also found in any of the following areas: the maxillary sinus, bones around the maxillary sinus, tissues under the skin, the eye socket, the base of the skull, and the ethmoid sinuses or cancer is found in one or more lymph nodes in the neck, none larger than 6 centimeters, and in any of the following areas: the front of the eye, the skin of the cheek, the base of the skull, behind the jaw, the bone between the eyes, and the sphenoid or frontal sinuses. Stage IVB: cancer has spread to either: one or more lymph nodes larger than 6 centimeters; or the back of the eye, the brain, the base and middle parts of the skull, nerves in the head, and/or the upper part of the throat behind the nose; cancer may also be found in one or more lymph nodes. Stage IVC: cancer has spread to other parts of the body.  Stage IV nasal cavity and ethmoid sinus cancer: Stage IV is divided into stages IVA, IVB, and IVC.  Stage IVA: cancer has spread to either one lymph node on the same side of the neck as the cancer and the lymph node is larger than 3 centimeters but smaller than 6 centimeters; or, cancer has spread to more than one lymph node anywhere in the neck, and all are 6 centimeters or smaller; cancer is also found in any of the following places: the nasal cavity or ethmoid sinus., the eye socket, the maxillary sinus, the roof of the mouth, and the bone between the eyes or cancer is found in one or more lymph nodes in the neck, and the lymph nodes are 6 centimeters or smaller; cancer is also found in any of the following areas: the front of the eye, the skin of the nose or cheek, front parts of the skull, the base of the skull, and the sphenoid or frontal sinuses.  Stage IVB: cancer is found in any of the following areas: the back of the eye, the brain, the middle parts of the skull, nerves in the head the upper part of the throat behind the nose and the base of the skull.  Cancer may also be found in one or more lymph nodes or cancer is found in a lymph node that is larger than 6 centimeters.  Stage IVC: cancer has spread to other parts of the body (from PDQ).


name: Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Lip and oral cavity cancer with moderately advanced local disease. Lip: Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose. Oral cavity: Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage III Lip and Oral Cavity Cancer AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Unresectable Sinonasal Squamous Cell Carcinoma

description: Sinonasal squamous cell carcinoma that is not amenable to surgical resection.


anaplastic carcinoma of salivary gland

description: A salivary gland carcinoma characterized by the presence of undifferentiated, anaplastic malignant epithelial cells.


Sinonasal Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the nasal cavity and paranasal sinuses.


name: Unresectable Paranasal Sinus Squamous Cell Carcinoma

description: Paranasal sinus squamous cell carcinoma that is not amenable to surgical resection.


name: Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck

description: Cutaneous squamous cell carcinoma of the head and neck that has spread from the original site of growth to another anatomic site.


Stage I Paranasal Sinus Cancer

description: Stage I includes: T1, N0, M0.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal Cancer by AJCC v6 Stage

description: A term that refers to the staging of nasal cavity and paranasal sinus carcinoma according to the American Joint Committee on Cancer, 6th edition.


Tongue Carcinoma

description: A malignant tumor arising from the epithelium that covers the tongue.  The vast majority of tongue carcinomas are moderately or poorly differentiated squamous cell carcinomas.


name: Metastatic Oral Cavity Mucoepidermoid Carcinoma

description: A mucoepidermoid carcinoma that arises from the oral cavity and has metastasized to another anatomic site.


Carcinoma in situ of middle ear

description: An intraepithelial squamous cell carcinoma that arises from the external auditory canal without evidence of invasion.


name: Salivary Gland Poorly Differentiated Carcinoma

description: A high-grade carcinoma that arises from the salivary glands. This category includes large and small cell types with or without neuroendocrine differentiation.


name: Low Grade Papillary Schneiderian Carcinoma

description: A rare sinonasal carcinoma characterized by the presence of a papillary architecture and bland morphological features similar to the Schneiderian papilloma, a pushing pattern of stromal invasion, and an increased risk of local recurrence.


name: Adenoid cystic carcinoma of the oral cavity recurrent

description: The reemergence of adenoid cystic carcinoma in the oral cavity after a period of remission.


name: Stage IV Oral Cavity Cancer AJCC v6 and v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a: (oral cavity) Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face).  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Recurrent Oral Cavity Carcinoma

description: The reemergence of carcinoma in the oral cavity after a period of remission.


name: Recurrent Paranasal Sinus Squamous Cell Carcinoma

description: The reemergence of paranasal sinus squamous cell carcinoma after a period of remission.


SMARCA4 -Deficient Sinonasal Carcinoma

description: An SWI/SNF-deficient sinonasal carcinoma characterized by inactivating mutation of SMARCA4 gene. It usually affects the nasal sinuses. It is composed of malignant large epithelioid anaplastic cells.


name: adenoid cystic carcinoma of floor of mouth

description: An adenoid cystic carcinoma of the oral cavity that arises from the floor of the mouth.


name: Stage I Nasal Cavity and Paranasal Sinus Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone. Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IV Lip and Oral Cavity Cancer AJCC v6 and v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose.  T4a (oral cavity): Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face).  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Localized Head and Neck Carcinoma

description: Head and neck carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites.


name: Sinonasal Adenocarcinoma, Intestinal-Type with Mixed Pattern

description: An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a mixture of growth patterns.


name: Mucoepidermoid carcinoma of the oral cavity recurrent

description: The reemergence of mucoepidermoid carcinoma in the oral cavity after a period of remission.


name: Squamous cell carcinoma of the oral cavity stage IV


name: Intermediate Grade Salivary Gland Mucoepidermoid Carcinoma

description: A salivary gland mucoepidermoid carcinoma with intermediate-grade histopathologic features.


name: Cutaneous Squamous Cell Carcinoma of the Head and Neck

description: A squamous cell carcinoma that arises from the skin of the head and neck.


Stage I Lip Carcinoma

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Salivary Gland Oncocytic Carcinoma

description: A high grade adenocarcinoma that arises from the salivary glands. The vast majority of cases have been described in the parotid gland.  It is characterized by the presence of malignant oncocytes.  It recurs and metastasizes to regional or distant anatomic sites.


name: Stage IVA Paranasal Sinus Cancer AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses.  Ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Adenoid cystic carcinoma of the tongue

description: An adenoid cystic carcinoma arising from the minor salivary glands in the tongue.


name: Metastatic Salivary Gland Adenocarcinoma

description: Salivary gland adenocarcinoma that has spread from its original site of growth to another anatomic site.


Refractory Head and Neck Carcinoma

description: A head and neck carcinoma that does not respond to treatment.


Recurrent Head and Neck Carcinoma

description: The reemergence of carcinoma in the head and neck region after a period of remission.


name: Minor Salivary Gland Sclerosing Microcystic Adenocarcinoma

description: A low-grade adenocarcinoma that arises from the minor salivary glands, usually in the oral cavity. It is characterized by the presence of a biphasic population of ductal and myoepithelial cells in a collagenous stroma. The prognosis is good.


Recurrent Sinonasal Carcinoma

description: The reemergence of nasal cavity or paranasal sinus carcinoma after a period of remission.


Head and Neck NUT Carcinoma

description: A highly aggressive, poorly differentiated carcinoma that arises from the head and neck. Most cases are in the nasal cavity and paranasal sinuses. It is characterized by mutations and rearrangement of the NUT gene.


name: Minor Salivary Gland Squamous Cell Carcinoma

description: A squamous cell carcinoma that affects the minor salivary glands.


name: Stage IVA Lip and Oral Cavity Cancer AJCC v6 and v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Lip and oral cavity cancer with moderately advanced local disease.  Lip: Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose.  Oral cavity: Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


name: High Grade Salivary Gland Mucoepidermoid Carcinoma

description: A salivary gland mucoepidermoid carcinoma with high-grade histopathologic features. It usually follows an aggressive clinical course.