Full thickness burn

description: An injury that includes all skin layers into the subcutaneous tissue due to chemical, friction, radiation or thermal exposure. The affected area appears dry and thickened; damage to nerve endings usually renders the wound painless.


Cervical Neuroendocrine Tumor

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A well-differentiated neuroendocrine neoplasm that arises from the cervix. It may be classified as G1 (low grade) or G2 (intermediate grade) neuroendocrine tumor.


name: Gastric Antrum Carcinoma In Situ AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial tumor without invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Primary Cutaneous Peripheral T-Cell Lymphoma, Rare Subtype

description: A rare, mature T-cell lymphoma arising from the skin.


Locally Advanced Urothelial Carcinoma

description: A urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Urothelial Carcinoma, High Grade

description: Urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


Accidental Injuries

description: Unintentional trauma to the body.


Resectable Malignant Solid Neoplasm

description: Malignant solid neoplasm that is amenable to surgical resection.


Congenital Vena Cava Abnormality

description: An abnormality of the superior or inferior vena cava that is present at birth. Representative examples include persistent left superior vena cava, absence of infrarenal inferior vena cava, or absence of the entire inferior vena cava.


Post-Treatment Lyme Disease Syndrome

description: A constellation of symptoms lasting months to years reported by some Lyme disease patients who had undergone previous antibiotic therapy.


name: Childhood Langerhans Cell Histiocytosis with Risk Organ Involvement

description: Langerhans cell histiocytosis that occurs during childhood and involves the bone marrow, spleen, liver, or lung.


Prostate Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the prostate gland.  Representative examples include acute and chronic prostatitis.


Stage IB Pancreatic Cancer AJCC v8

description: Stage IB includes: T2, N0, M0. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metanephric stromal tumor

description: A rare benign renal neoplasm composed of moderately cellular spindle cells. It occurs mostly in infancy and childhood.


name: Recurrent Glioneuronal and Neuronal Tumors

description: The reemergence of glioneuronal and neuronal tumors after a period of remission.


Lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Miscellaneous Neoplasm

description: A benign or malignant neoplasm which is not further characterized.


name: Esophageal Adenocarcinoma by AJCC v8 Pathologic Stage

description: A term that refers to the pathologic staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Integumentary System Signs and Symptoms

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Patient complaints (symptoms), physical and/or laboratory findings related to the skin or integument.


Stage I Cervical Cancer AJCC v6 and v7

description: Stage I includes: I (T1, N0, M0); IA (T1a, N0, M0); IA1 (T1a1, N0, M0); IA2 (T1a2, N0, M0); IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1: Cervical carcinoma confined to uterus (extension to corpus should be disregarded). T1a: Invasive carcinoma diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. T1a1: Measured stromal invasion 3.0 mm or less in depth and 7.0 or less horizontal spread.  T1a2: Measured stromal invasion more than 3.0mm and not more than 5.0 mm with a horizontal spread 7.0mm or less. T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


COVID-19-Associated Encephalitis

description: Encephalitis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Childhood Neurofibroma

description: A neurofibroma that occurs during childhood.


name: Recurrent Malignant Nongerminomatous Germ Cell Tumor

description: The reemergence of a malignant nongerminomatous germ cell tumor after a period of remission.


PTEN Deficiency

description: A condition of decreased or absent presence or activity of phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, which is associated with multiple hamartoma syndrome (Cowden syndrome) and increased risk for development of several types of malignant cancers, including head and neck, breast, lung and prostate cancer and glioblastoma.


name: Refractory Malignant Male Reproductive System Neoplasm

description: Malignant male reproductive system neoplasm that is resistant to treatment.


name: Ampulla of Vater Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region. The mitotic count is 2-20 per 10 HPF.


Advanced Lymphoma

description: Lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IIC Appendix Carcinoma AJCC v7

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades other organs or structures.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Chest Pain Along Left Anterior Axillary Line

description: The location of the chest pain is along the anterior axillary line on the left side.


Cervical Cancer by AJCC v9 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 9th edition. This staging system applies to carcinomas and carcinosarcomas. It does not apply to sarcomas, lymphomas, and melanomas. Sarcomas are staged according to the corpus uteri classification for sarcomas. Lymphomas are staged according to Hodgkin and non-Hodgkin lymphoma classification. Melanomas are not staged. (from AJCC 9th Ed.)


bite injury

description: A wound inflicted by the teeth or fangs of an individual or animal.


Childhood Schwannoma

description: A schwannoma that occurs during childhood.


name: Digestive System Neuroendocrine Tumor by AJCC v7 Stage

description: A term that refers to the staging of a digestive system neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system.


name: Childhood Hodgkin Lymphoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood Hodgkin lymphoma according to the Toronto childhood cancer staging guidelines v2. Staging is the same for both tiers (tier 1 and 2).


Rectal Pain

description: Pain in the rectal area.


Stage IIA1 Cervical Cancer AJCC v8

description: Stage IIA1 includes: T2a1, Any N, M0. T2a1: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Refractory Neuroendocrine Carcinoma

description: Neuroendocrine carcinoma that does not respond to treatment.


Cutaneous Melanoma by AJCC v8 Stage

description: A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system. This staging system does not apply to melanoma of the conjunctiva, melanoma of the uvea, mucosal melanoma arising in the head and neck, and mucosal melanoma of the urethra, vagina, rectum, and anus. (from AJCC 8th Ed.)


Dermal nerve sheath myxoma

description: A usually painless, slow growing benign tumor that most often arises from the extremities. It is characterized by the presence of abundant myxoid matrix and small epithelioid neoplastic Schwann cells.


Congenital Amegakaryocytosis

description: A rare disorder of infancy characterized by marked reduction or absence of megakaryocytes and thrombocytopenia.


Gastroesophageal Junction Carcinoma

description: A carcinoma that arises from the gastroesophageal junction. The vast majority of cases are adenocarcinomas. Rare cases are neuroendocrine carcinomas.


Cannabis dependence, episodic

description: Physical and psychological dependence on the drug cannabis, which is associated with a pattern of episodic use.


Closed dislocation of hip

description: A closed dislocation of the hip.


name: Metastatic Pancreatic Neuroendocrine Neoplasm

description: A pancreatic neuroendocrine neoplasm that has spread from its original site of growth to another anatomic site.


name: Myelodysplastic Chronic Myelomonocytic Leukemia

description: Chronic myelomonocytic leukemia characterized by the absence of a markedly elevated white blood cell count in the peripheral blood.


Poroid Hidradenoma

description: A poroma characterized by the presence of a single or several nodules of neoplastic cells forming solid and cystic areas in the dermis.


name: Non-Neoplastic Hematologic and Lymphocytic Disorder

description: A non-neoplastic disorder that arises from hematopoietic and lymphoid cells. It is characterized by the absence of a clonal cellular component. It rarely progresses to a malignant neoplasm.


Stage II Urethral Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: For male penile urethra and female urethra: Tumor invades any of the following: corpus spongiosum, periurethral muscle. For prostatic urethra: Tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Mesonephric Hyperplasia

description: A hyperplasia of the mesonephric cells.


name: Stage IB Ampulla of Vater Cancer AJCC v7

description: Stage IB includes: T2, N0, M0. T2: Tumor invades the duodenal wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Corrosive injury

description: Destruction of tissue by a chemical substance.


name: Contact lens overwear syndrome (disorder)

description: Ocular pain which may be very intense, accompanied by corneal epithelium damage, conjunctival injection, lacrimation, blepharospasm, photophobia and hazy vision following corneal edema caused by overwear of contact lenses, principally the PMMA type.


neuroendocrine carcinoma of anal canal

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Acral Melanoma

description: A cutaneous melanoma that arises from the palms, soles, and nails.


name: Lugano Classification Limited Stage Adult Hodgkin Lymphoma AJCC v8

description: Limited stage adult Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Burning Chest Pain

description: The sensation of chest pain described as an intense discomfort, similar to that experience as a result of a thermal burn, distinct from sharp, stabbing or aching, often related to nerves; sometimes used to describe gastric or esophageal pain.


Unresectable Adenoid Cystic Carcinoma

description: Adenoid cystic carcinoma that is not amenable to surgical resection.


Intraoperative Head and Neck Injury

description: Damage to head and neck during a surgical procedure.


name: AIDS-Related Diffuse Small Cleaved Cell Lymphoma

description: A non-Hodgkin lymphoma occurring in HIV-positive patients.  It is composed of small cleaved lymphocytes.


name: Bile Duct Mucinous Cystic Neoplasm, Low Grade

description: A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of mild atypia.


Childhood Gliosarcoma

description: A gliosarcoma that occurs during childhood.


name: Undifferentiated Carcinoma of Unknown Primary

description: An undifferentiated carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified.


Parapsoriasis lichenoides

description: A rare condition that stimulated chronic radiodermatitis.  It is considered a variant of mycosis fungoides.


name: acute undifferentiated leukemia in relapse

description: The reemergence of acute undifferentiated leukemia after a period of remission.


Sweat Gland Tubular Carcinoma

description: An aggressive adenocarcinoma that arises from the sweat glands. It usually presents as a firm, erythematous nodular lesion in the axilla. Morphologically, it is characterized by the presence of tubular structures and apocrine differentiation.


Stage III Vulvar Cancer AJCC v8

description: Stage III includes: T1-T2, N1-N2c, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N1: Regional lymph node metastasis with one or two lymph node metastases each less than 5 mm, or one lymph node metastasis equal to 5 mm. N2a: Three or more lymph node metastases each less than 5 mm. It includes micrometastasis, N2mi. N2b: Two or more lymph node metastases equal to 5 mm. N2c: Lymph node(s) metastasis with extranodal extension. M0: No distant metastasis. (AJCC 8th Ed.)


Parathyroid chief-cell hyperplasia

description: A hyperplasia of the chief cells of the parathyroid gland.


name: Recurrent Platinum-Sensitive Endometrial Carcinoma

description: The reemergence of platinum-sensitive endometrial carcinoma after a period of remission.


Lower Thigh Pain

description: A painful sensation in the distal thigh area.


Balloon cell nevus

description: An uncommon variant of melanocytic nevus. It presents as a small pigmented skin lesion. It is characterized by the presence of large melanocytes with clear, foamy or finely vacuolated cytoplasm. It may recur if it is not completely excised.


Endocrine Therapy Toxicity

description: Indicates that a toxicity adverse effect has been experienced during endocrine drug treatment.


Microcyst

description: A tiny cyst that is usually identified by microscopic examination in a tissue specimen.


Sacral Myelocele

description: Herniation of spinal cord tissue and meninges through a defect in the sacral region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


Metastatic Neoplasm to the Bladder

description: The spread of a malignant neoplasm to the urinary bladder wall from an adjacent or distant anatomic site.


name: Stage y-III Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Incomplete excision of the tumor (gross or microscopic extension beyond the resection margins). Involved abdominal lymph nodes, including necrotic tumor or chemotherapy-induced changes. Tumor rupture before or intraoperatively. Tumor has penetrated the peritoneal surface. Tumor thrombi present at resection margins. Surgical biopsy prior to resection (does not include needle biopsy). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Lugano Classification Stage III Adult Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Acute Submassive Pulmonary Embolism

description: Acute pulmonary embolism with evidence of right ventricular dysfunction, but not associated with systemic hypotension.


name: Enterochromaffin-Like Cell Neuroendocrine Tumor G1

description: A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) arising from the gastrointestinal tract. It is characterized by the presence of enterochromaffin-like type granules in the neoplastic cells.


name: Invasive Conventional Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by the presence of malignant cells forming trabeculae, cords, sheets, and nests. Individual malignant cells are also present.


Stage IVB Gallbladder Cancer AJCC v7

description: Stage IVB includes: (Any T, N2, M0); (Any T, Any N, M1).  N2: Metastases to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes.  M0: No distant metastasis.  M1: Distant metastasis. (from AJCC 7th Ed.)


name: Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Metastatic Malignant Neoplasm in the Female Reproductive System

description: The spread of a malignant neoplasm to the female reproductive system from an adjacent or distant anatomic site.


name: IgM Monoclonal Gammopathy of Undetermined Significance, Not Otherwise Specified

description: A subtype of IgM monoclonal gammopathy of undetermined significance that includes cases associated with MYD88 mutation and cases associated with the presence of monoclonal B-lymphocytes without the presence of abnormal lymphoplasmacytic aggregates that are diagnostic of lymphoplasmacytic lymphoma or other small B-lymphocytic neoplasms.


Chronic Total Occlusion Vessel

description: A longstanding, complete blockage of a vessel. (ACC)


Hematoma of rectus sheath

description: A collection of blood in the rectus sheath due to disruption of the superior or inferior epigastric arteries, which may present following direct trauma to the rectus abdominis muscle or anticoagulation therapy.


name: Malignant Germinative Follicular Epithelium Neoplasm

description: A malignant neoplasm that arises from germinative follicular epithelial cells.


name: Ampulla of Vater Cancer by AJCC v7 Stage

description: A term that refers to the staging of ampulla of Vater cancer according to the American Joint Committee on Cancer, 7th edition.


name: Recurrent Childhood Central Nervous System Neoplasm

description: The reemergence of central nervous system neoplasm in childhood after a period of remission.


COVID-19-Associated Stroke

description: Cerebrovascular accident caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Stage 0 Uterine Corpus Cancer

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis.  This staging applies to carcinomas and carcinosarcomas.  FIGO no longer includes Stage 0 (Tis). (AJCC 7th ed.)


name: Metastatic Digestive System Neuroendocrine Tumor G2

description: Digestive system neuroendocrine tumor G2 that has spread from its original site of growth to another anatomic site.


Stage IVB Cervical Cancer FIGO 2018

description: The cervical carcinoma has spread to distant organs. (FIGO 2018)


name: Cervical Papillary Squamous Cell Carcinoma

description: A human papillomavirus-related cervical squamous cell carcinoma characterized by the presence of papillary structures covered with epithelial cells which show features of cervical intraepithelial neoplasia. The malignant cellular component below the papillary structures is a squamous cell carcinoma.


Intraoperative Hemorrhage

description: Uncontrolled bleeding during a surgical procedure.


name: Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: An undifferentiated high grade pleomorphic sarcoma that arises from the bone and occurs during childhood.


Refractory Primary Amyloidosis

description: Primary amyloidosis that does not respond to treatment.


Plasma Kallikrein Deficiency

description: A coagulation disorder characterized by the partial or complete absence of plasma-type kallikrein activity in the blood.


name: Childhood Refractory Malignant Solid Neoplasm

description: A childhood malignant solid neoplasm that does not respond to treatment.


Factor VII Inactivation

description: Presence of inactivating antibodies to factor VII in the blood.


Intraoperative Urinary System Injury

description: Damage to any part of the urinary system during a surgical procedure.


Blast Injuries

description: The result of physical trauma sustained in an explosion.


Discoid Rash

description: A disc-shaped patch(es) of skin inflammation that is red, raised, and scaly; it typically develops on the face, scalp, and neck, and often leaves scars and dyspigmentation as a result of postinflammatory hyperpigmentation.


Signet Ring Cell/Histiocytoid Carcinoma

description: A rare aggressive adnexal carcinoma preferentially affecting the eyelid and histopathologically resembling a metastatic lobular carcinoma of the breast and/or some adenocarcinomas arising in the gastrointestinal tract. (WHO 2018)


benign mature teratoma of pancreas

description: A mature teratoma that arises from the pancreas.


name: Recurrent Low Grade Adult Non-Hodgkin's Lymphoma


Early Prosthetic Valve Endocarditis

description: Prosthetic valve endocarditis that occurs days to weeks after surgery.


Advanced Pancreatic Carcinoma

description: Pancreatic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Meningohydroencephalocele

description: A congenital neural tube closure defect resulting in protrusion of the brain, the meninges, and the ventricular system through an opening in the skull, usually involving the squamous part of the occipital bone..


Skin squamous cell carcinoma metastatic

description: Squamous cell carcinoma of the skin which has spread to other anatomic sites.


Refractory Cervical Adenocarcinoma

description: Cervical adenocarcinoma that is resistant to treatment.


Chest Pain Along Midclavicular Line

description: The location of the chest pain is along an imaginary vertical line on the chest originating from the midpoint of a clavicle.


High Grade Osteosarcoma

description: An aggressive osteosarcoma with high-grade morphological features. This category includes high-grade surface osteosarcoma and conventional osteosarcoma.


name: Poorly Differentiated Prostate Adenocarcinoma

description: An invasive prostate adenocarcinoma characterized by the presence of poorly differentiated malignant cells.


Invasive Nested Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by a nested growth pattern.


Sickle cell-thalassemia disease

description: Hemolytic anemia, in which patients are heterozygous for both the sickle cell gene and a thalassemia gene.


Unfavorable Hodgkin Lymphoma

description: A Hodgkin lymphoma with unfavorable prognosis.


Primary Parathyroid Gland Hyperplasia

description: Parathyroid gland hyperplasia that occurs in the absence of physiological stimuli.


Stage IVB Osteosarcoma AJCC v7

description: Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N1: Regional lymph node metastasis.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Infarction of spinal cord

description: Ischemic necrosis of the spinal cord caused by occlusion of the arteries that supply blood to the spinal cord. Signs and symptoms include intermittent back pain, pain in the legs, paralysis, and incontinence.


Lower Ribs Pain

description: A sensation of discomfort emanating from the inferiormost (verterbrochondral or vertebral) ribs.


Uterine Corpus Cancer by AJCC v7 Stage

description: A term that refers to the staging of uterine corpus cancer (carcinoma or carcinosarcoma) according to the American Joint Committee on Cancer, 7th edition.


Recurrent Malignant Bone Neoplasm

description: Reemergence of a malignant bone neoplasm after a period of remission.


name: Gallbladder Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma

description: A mucinous cystic neoplasm that arises from the gallbladder and it is associated with an invasive carcinomatous component.


name: Sporadic Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is not caused by inherited genetic mutations.


Carcinoid tumor of the liver

description: An extremely rare, well differentiated neuroendocrine neoplasm arising from the liver. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation.


name: TdT Positive Acute Lymphoblastic Leukemia


Adult Gliosarcoma

description: A gliosarcoma occurring in adults.


Stage II Ureter Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor invades the muscularis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Mosquito-borne hemorrhagic fever

description: A group of viral illnesses that are vectored by mosquitoes, and that are characterized by increased susceptibility to bleeding diatheses.


Hypomyelinating Leukodystrophy-22

description: An autosomal dominant condition caused by mutation(s) in the CLDN11 gene, encoding claudin-11.  It is characterized by global developmental delay, mild impaired intellectual development, limited ability to walk, and hypomyelinating leukodystrophy on MRI.


name: congenital renal arteriovenous malformation

description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the kidney.


Craniotubular Hyperostosis

description: A group of sclerosing bone dysplasias characterized by pronounced sclerosis of the cranial vault and the long bones, resulting in increased cortical bone density. Most cases are caused by mutation(s) in the SOST or LRP5 genes, encoding sclerostin and low-density lipoprotein receptor-related protein 5, respectively. Other genes have been implicated, and some cases have been described, but do not yet have identified genetic mutations.


name: Stage IB Gestational Trophoblastic Tumor AJCC v7

description: Stage IB includes: T1, M0, Risk factors: high risk.  T1: Tumor confined to uterus.  M0: No distant metastasis.  (AJCC 7th ed.)


Disseminated carcinoma

description: Carcinoma that is spread throughout the body.


Insomnia due to organic factors

description: Insomnia as a result of a physiological cause.


Congenital kyphosis

description: An abnormally increased curvature of the thoracic portion of the spine that is present at the time of birth.


name: Human Papillomavirus-Related Malignant Neoplasm in AIDS Patient

description: A malignant neoplasm caused by human papillomavirus in an a patient with a history of AIDS.


Metastatic Malignant Solid Neoplasm

description: A malignant solid neoplasm that has spread from its original site of growth to another anatomic site.


Tiring Pain

description: A sensation of discomfort or distress that renders an individual weary and without energy.


name: Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Alkylating Agent-Related Acute Myeloid Leukemia

description: Acute myeloid leukemia occurring as late complication of prior therapy with alkylating agents.


name: Invasive Bladder Large Nested Urothelial Carcinoma

description: A rare invasive bladder urothelial carcinoma characterized the presence of medium to large nests of malignant cells.


name: Complication of labor and delivery, unspecified

description: The occurrence of a pregnancy complication during childbirth, which includes both labor (the process of childbirth) and delivery (the birth itself).


Fibromyxolipoma

description: A benign well-circumscribed tumor composed of mature adipocytes, characterized by areas of abundant fibrous tissue and extensive myxoid change.


Salt-Wasting 21-Hydroxylase Deficiency

description: A classic form of congenital adrenal hyperplasia characterized by complete absence of 21-hydroxylase activity resulting in deficiency of glucocorticoids and mineralocorticoids accompanied by androgen excess causing virilization in female infants. Mineralocorticoid deficiency results in renal salt-wasting, and if untreated, hyponatremia, hyperkalemia, and shock.


Appendix Mucinous Cystadenoma

description: A cystically dilated epithelial neoplasm arising from the appendix.  It is characterized by the presence of a cystic structure that is filled with mucus.


name: Hodgkin's disease, nodular sclerosis of lymph nodes of multiple sites

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Metastatic Bladder Small Cell Neuroendocrine Carcinoma

description: Bladder small cell neuroendocrine carcinoma that has spread to another anatomic site.


name: Prostate Cancer by Whitmore-Jewett Stage

description: A term that refers to the staging of prostate carcinoma according to the Whitmore-Jewett staging system.


name: Clinical Stage II Cutaneous Melanoma AJCC v8

description: Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA

description: Chronic eosinophilic leukemia characterized by the rearrangement of the PDGFRA gene, most often resulting in the formation of FIP1L1-PDGFRA fusion transcripts.


name: Childhood Acute Lymphoblastic Leukemia by Toronto Guidelines v2

description: A term that refers to the staging of childhood acute lymphoblastic Leukemia according to the Toronto childhood cancer staging guidelines v2.


Angiosarcoma recurrent

description: The reemergence of angiosarcoma after a period of remission.


Glioblastoma by Gene Expression Profile

description: Classification of glioblastoma into molecular subtypes as defined by gene expression profiling.


Metastatic Midgut Neuroendocrine Tumor

description: A midgut neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


Stage III Anal Cancer AJCC v8

description: Stage III includes: IIIA: (T1, N1, M0); (T2, N1, M0); IIIB: (T4, N0, M0); IIIC: (T3, N1, M0); (T4, N1, M0). T1: Tumor 2 cm or smaller. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. T3: Tumor larger than 5 cm. T4: Tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder. N0: No regional lymph node metastasis. N1: Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes. M0: No distant metastasis. (AJCC 8th ed.)


Primary acquired melanosis

description: A spectrum of neoplastic changes that occur in the conjunctiva and range from melanocytic hyperplasia through degrees of atypia to melanoma in situ. The lesions are generally unilateral but often multifocal and appear as flat, irregular brown discolorations of the conjunctiva. They usually affect middle-aged and elderly Caucasians. (WHO 2018)


Meningeal Gliomatosis

description: Diffuse or multifocal infiltration of the meninges by malignant glioma.


Mediastinal Hemorrhage

description: Bleeding originating from the mediastinum.


Gallbladder Goblet Cell Adenocarcinoma

description: An invasive mixed adenoneuroendocrine carcinoma of the gallbladder characterized by the presence of neoplastic signet-ring cells resembling goblet cells of the intestine.


name: High Grade Prostatic Intraepithelial Neoplasia, Small Cell Neuroendocrine Variant

description: High grade prostatic intraepithelial neoplasia characterized by the presence of small neuroendocrine cells in the affected glands.


name: Locally Advanced Ampulla of Vater Carcinoma

description: Carcinoma that arises from the ampulla of Vater and has spread to nearby tissues or lymph nodes.


Intraoperative Respiratory Injury

description: Damage to the respiratory system during a surgical procedure.


name: Monomorphic Post-Transplant Lymphoproliferative Disorder

description: A clonal lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed lymphocytes or plasma cells.  It includes two variants: monomorphic B-cell and monomorphic T/NK cell post-transplant lymphoproliferative disorders.


name: Pathologic Stage IV Retinoblastoma AJCC v8

description: Stage IV includes: Any pT, Any N, cM1 or pM1, Any H. cM1: Distant metastasis without microscopic confirmation. pM1: Distant metastasis with microscopic confirmation. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


EBV-Associated Smooth Muscle Tumor

description: A rare smooth muscle neoplasm of uncertain biological potential. It is associated with Epstein-Barr virus infection and seen in patients with immunodeficiency, including primary immunodeficiency, HIV/AIDS infection, and post-transplant immunosuppression.


Cancer-Associated Pain

description: Pain associated with cancer or its diagnosis or treatment.


Locally Advanced Carcinoma

description: A carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Chest Pain Along Left Middle Sternal Border

description: The location of the chest pain is along the left middle border of the sternum.


Myocardial degeneration

description: Degeneration of myocardial tissue.


Astler-Coller C2 Colon Carcinoma

description: Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


name: Postneoadjuvant Therapy Stage IVB Esophageal Adenocarcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Gastrinoma, malignant

description: A gastrin-producing neuroendocrine tumor.  It is characterized by inappropriate secretion of gastrin and associated with Zollinger Ellison syndrome.  It displays vascular invasion and metastasizes to other anatomic sites.


name: Congenital Defects of Phagocyte Number, Function, or Both

description: A group of diseases or disorders caused by genetic defects within the immune system and comprising: Congenital neutropenia; Defects of motility; Defects of respiratory burst; and other nonlymphoid defects.


Megakaryocytic Neoplasm

description: A neoplasm affecting cells of the megakaryocytic lineage.


name: Chronic Cutaneous Graft Versus Host Disease

description: Chronic graft versus host disease (GvHD) occurring in the skin.


Injury of bronchus

description: Trauma to the lung bronchi.


EBV positive mucocutaneous ulcer

description: A rare Epstein-Barr virus-positive B-cell lymphoproliferative disorder that affects mucosal sites (including oral mucosa, palate, tonsils, and gastrointestinal tract) and skin. It presents with well-circumscribed, often painful ulcers. It is associated with immune suppression, including age-related and drug-induced immunosuppression. In the majority of cases the lesions regress either spontaneously or following withdrawal of the immunosuppression therapy.


Malignant melanoma in junctional nevus

description: A melanoma arising from a melanocytic nevus which involves the dermal-epidermal junction of the skin.


name: Childhood Malignant Bone Neoplasm by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood malignant bone neoplasm according to the Toronto childhood cancer staging guidelines v2. Staging is the same for both tiers (tier 1 and 2).


description: A rare mucinous cystadenocarcinoma that arises from the paratesticular structures.


Recurrent Cancer of Gallbladder

description: The reemergence of gallbladder carcinoma after a period of remission.


Orbivirus infection

description: An infection that is caused by Orbivirus.


Unclassified Hepatocellular Adenoma

description: A hepatocellular adenoma without distinguished morphologic characteristics or known molecular abnormalities.


name: Congenital arteriovenous malformation of gastrointestinal tract

description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the gastrointestinal tract.


Contact dermatitis caused by acid

description: Contact dermatitis caused by exposure to acids.


Congenital His bundle tachycardia

description: A congenital disorder characterized by an electrocardiographic finding of tachycardia that affects neonates and infants. It results from an increased automaticity in the atrioventricular node and His bundle.


Extracranial Solid Neoplasm

description: A solid neoplasm involving any anatomic site other than the brain.


Childhood Ganglioneuroma

description: A ganglioneuroma that occurs during childhood.


High Metal Ion Levels

description: High blood or serum levels of ions which are attributed to one or more medical devices used, such as but not limited to Co, Cr, Ti, Ni, Mo.


Adenocarcinoma endometrial recurrent

description: The reemergence of endometrioid adenocarcinoma after a period of remission.


Surgical Ciliated Cyst

description: A rare cyst that results from traumatic (usually surgical) implantation of respiratory epithelium in the jaw bones.


name: Myelodysplastic/Myeloproliferative Neoplasm Post Cytotoxic Therapy

description: A myelodysplastic/myeloproliferative neoplasm arising as a result of the mutagenic effect of chemotherapy agents and/or radiation that are used for the treatment of neoplastic or non-neoplastic disorders.


name: Adult Favorable Prognosis Hodgkin Lymphoma

description: A Hodgkin lymphoma with favorable prognosis that occurs during adulthood.


Unresectable Mucosal Melanoma

description: Mucosal melanoma that is not amenable to surgical resection.


Childhood Malignant Bone Neoplasm

description: A malignant neoplasm that affects the bone or articular cartilage and occurs during childhood.


name: Metastatic malignant neoplasm to soft tissues

description: A malignant neoplasm that has spread to the soft tissues from another anatomic site.


A2/3 Hydronephrosis

description: Antenatal hydronephrosis with the following clinical findings: 1) an anterior-posterior renal pelvis diameter (APRPD) of greater than or equal to 7mm at less than 28 weeks, 2) greater than or equal to10 mm at greater than or equal to 28 weeks, or 3) any one of the following findings: a)dilation of peripheral calyces, b) abnormal parenchymal thickness or appearance, c) visibly dilated ureter, d) an abnormal bladder, or e) the presence of oligohydramnios suspected to be related to the urinary tract. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


Carcinoma Unspecified Site

description: Carcinoma in which the site of involvement is not specified.


Locally Advanced Gallbladder Carcinoma

description: Gallbladder carcinoma that has spread to nearby tissues or lymph nodes.


Stage I Adult Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Nerve injury

description: Injury to nervous tissue.


Stage II Esophageal Cancer AJCC v7

description: Stage II includes: For squamous cell carcinoma: IIA (T2-3, N0, M0, G1, GX, Tumor location: Upper, middle); (T2-3, N0, M0, G2-3, Tumor location: Lower, X); IIB (T2-3, N0, M0, G2-3, Tumor location: Upper, middle); (T1-2, N1, M0, Any G, Tumor location: Any).  For adenocarcinoma: IIA (T2, N0, M0, G3); IIB (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Acute Myeloid Leukemia with STAT5B-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of STAT5B-RARA fusion protein.


Posterior Subcapsular Cataract Grade 2

description: A stage of posterior subcapsular cataract characterized by 30% of the posterior capsule obscured by opacity. (Modified LOCS II)


Mucosal ulcer

description: A circumscribed loss of integrity of the mucous membrane.


Recurrent T-Cell and NK-Cell Neoplasm

description: The reemergence of T-cell and NK-cell neoplasm after a period of remission.


Cannabis dependence, continuous

description: Physical and psychological dependence on the drug cannabis, which is associated with a pattern of continuous use.


Skin tumor of neural origin

description: A peripheral nervous system neoplasm that arises from the dermis.


Locally Advanced Gastric Adenocarcinoma

description: A gastric adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Anal Canal Neuroendocrine Tumor G1

description: A well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the anal canal. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


name: Bile Duct Biliary Intraepithelial Neoplasia

description: A neoplastic, non-invasive lesion that affects the intrahepatic or extrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


Locally Advanced Sarcoma

description: Sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Adverse reactions

description: Any noxious and unintended response(s) to a medical product or procedure, for which a causal relationship with this product or procedure is at least a reasonable possibility i.e., the relationship cannot be ruled out.


name: Childhood EBV-Associated Smooth Muscle Tumor

description: An EBV-associated smooth muscle tumor that occurs during childhood.


Childhood Pilomatricoma

description: A pilomatricoma that occurs during childhood.


name: Locally Advanced Unresectable Bone Sarcoma

description: A bone sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Borderline Fallopian Tube Neoplasm

description: A rare epithelial tumor arising from the fallopian tube without definitive morphologic characteristics of malignancy.  This category includes borderline mucinous and serous neoplasms and borderline endometrioid tumor.


name: Recurrent Endometrial Serous Adenocarcinoma

description: The reemergence of endometrial serous adenocarcinoma after a period of remission.


name: Platinum-Refractory Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that progresses during platinum therapy or within one month of completing platinum therapy.


Stage IV Skin Cancer

description: Stage IV includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T Any, N3, M0); (T4, N Any, M0); (T Any, N Any, M1).  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  T3: Tumor with invasion of maxilla, mandible, orbit, or temporal bone.  T4: Tumor with invasion of skeleton or perineural invasion of skull base.  N0: No regional lymph node metastasis.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M1: Distant metastases.  (AJCC 7th Ed.)


Sebaceoma

description: A benign neoplasm characterized by sebaceous cell differentiation. It arises from the dermis and typically affects the face and neck.


Breast Papillary Neoplasm

description: A benign or malignant papillary neoplasm that arises from the breast.  It is characterized by the presence of epithelial proliferations that are supported by fibrovascular cores.  Representative examples are intraductal papilloma and papillary carcinoma.


name: Castleman Disease, Hyaline-Vascular Type

description: The commonest type of Castleman disease. It is seen most commonly in the mediastinum. Histologically this is characterized by hyalinized germinal centers surrounded by small lymphocytes in a concentric fashion, giving an onion skin appearance.


name: Invasive Bladder Giant Cell Urothelial Carcinoma

description: An invasive urothelial carcinoma of the bladder with giant cells.


Childhood Classic Hodgkin Lymphoma

description: Classic Hodgkin lymphoma that occurs during childhood.


Pelvic hemorrhage

description: Bleeding within the pelvic cavity.


name: Unresectable Digestive System Neuroendocrine Neoplasm

description: A digestive system neuroendocrine neoplasm that is not amenable to surgical resection.


Enteroglucagonoma

description: An endocrine neoplasm producing glucagon.


Hidroacanthoma Simplex

description: A poroma characterized by the presence of aggregates of basaloid cells confined to the epidermis.


Recurrent Nevus

description: A nevus that recurs after incomplete surgical removal, biopsy, or trauma. (WHO 2018)


Venomous Animal Contact

description: Contact with a venomous animal.


name: Locally Advanced Squamous Cell Carcinoma

description: A squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Major Congenital Anomaly

description: A major congenital anomaly is a structural or functional defect with the following three characteristics: 1) Of prenatal origin; 2) Present at the time of live birth or fetal demise, or in utero; 3) Affecting (or has the propensity to affect) the health, survival, or physical or cognitive functioning of the individual.


Carcinoma of unknown primary

description: A carcinoma which has metastasized from an unknown primary anatomic site.


name: Hematopoietic and Lymphoid Neoplasm (Antiquated)


name: Invasive Lymphoepithelioma-Like Urothelial Carcinoma

description: Invasive urothelial carcinoma with lymphoepithelioma-like features.


Clinical Chorioamnionitis

description: Inflammation of the fetal sac membranes, characterized by otherwise unexplained fever (at or above 38 degree C (100.4F)) with one or more of the following: uterine tenderness and/or irritability, leukocytosis, fetal tachycardia, maternal tachycardia, or malodorous vaginal discharge.


Lumbar meningomyelocele

description: A congenital abnormality in the lumbar region of the spine, in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Autoimmune Atrophic Chronic Gastritis

description: Chronic atrophic gastritis that is caused by autoimmune destruction of parietal cells in the stomach resulting in hypochlorhydria and decreased production of intrinsic factor.


Stage I Low-CSD Melanoma AJCC v7

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Locally Advanced Bladder Adenocarcinoma

description: Bladder adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Malignant Bladder Paraganglioma

description: An extra-adrenal sympathetic paraganglioma of the bladder that metastasizes to other anatomic sites.


Infant Leukemia

description: An acute lymphoblastic or acute myeloid leukemia that occurs in infancy.


Distal Esophagus Adenocarcinoma

description: An adenocarcinoma arising from the lower third of the esophagus. The vast majority of esophageal adenocarcinomas involve the lower third of the esophagus.


name: Cervical intraepithelial neoplasia grade 1

description: Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of mild dysplastic changes.


Diffuse KATP-Associated Hyperinsulinism

description: KATP-associated hyperinsulinism affecting all pancreatic beta cells.


Recurrent Acute Erythroid Leukemia

description: The reemergence of acute erythroid leukemia after a period of remission.


name: Anxiety disorder due to a general medical condition

description: An anxiety disorder in which the symptoms of anxiety have been determined to be the direct physiological consequence of a general medical condition.


Stage IVB Cervical Cancer FIGO 2009

description: Cervical carcinoma involving distal organs outside the pelvis. (FIGO 2009)


Basal cell carcinoma - keratotic

description: A variant of basal cell carcinoma with the architectural features of a nodular basal cell carcinoma.  It is characterized by the formation of keratin (horn cysts) in the center of the tumor islands.  Dystrophic calcification is frequently present.


Complication

description: Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure.


Anaplastic Diencephalic Astrocytoma

description: An anaplastic astrocytoma that occurs in the diencephalon.


Sclerosing Blue Nevus

description: A dendritic blue nevus characterized by the presence of prominent sclerotic stromal collagen.


description: A reactive proliferation of the conjunctival squamous epithelium not associated with glandular elements.


name: Philadelphia Chromosome Negative BCR-ABL1 Negative Chronic Myelogenous Leukemia


Recurrent Lymphoid Leukemia

description: The reemergence of lymphoid leukemia after a period of remission.


name: Lymphoproliferative Disease Associated with Primary Immune Disorder

description: A lymphoid proliferation that arises in the setting of immune deficiency due to a primary immunodeficiency or immunoregulatory disorder. The primary immune disorders most frequently associated with lymphoproliferative disorders are ataxia-telangiectasia, Wiskott-Aldrich syndrome, common variable immunodeficiency, severe combined immunodeficiency, X-linked lymphoproliferative disease, Nijmegen breakage syndrome, hyper-IgM syndrome, and autoimmune lymphoproliferative syndrome. (WHO 2017)


name: Radiating Chest Pain Along Right Lower Sternal Border

description: The location of the radiating chest pain is along the right lower sternal border.


name: Recurrent Histiocytic and Dendritic Cell Neoplasm

description: The reemergence of a histiocytic and dendritic cell neoplasm after a period of remission.


Stage III Childhood Hodgkin Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Vascular anomaly of eyelid

description: Any non-neoplastic or neoplastic disorder affecting the arteries, veins, or lymphatic vessels of the eyelid.


name: Stage III Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, Any N, M0). T1: Pheochromocytoma measuring less than 5 cm in greatest dimension, with no extra-adrenal invasion. T2: Pheochromocytoma measuring 5 cm or more in greatest dimension or paraganglioma-sympathetic of any size, with no extra-adrenal invasion. T3: Tumor of any size with invasion into surrounding tissues (e.g., liver, pancreas, spleen, kidneys). N1: Regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Stage IIIA Esophageal Adenocarcinoma AJCC v7

description: Stage IIIA includes: (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


verrucous carcinoma of vagina

description: A squamous cell carcinoma that arises from the vagina and is characterized by a papillary growth pattern, acanthotic epithelium with minimal or absent atypia, and pushing borders.


name: Testicular Seminoma with Syncytiotrophoblastic Cells

description: A testicular seminoma characterized by the presence of syncytiotrophoblastic giant cells.


Peritoneal Implant

description: Deposits of borderline, malignant, and rarely benign tumors, usually from the ovary, on the peritoneal surface.


Resectable Cutaneous Melanoma

description: Cutaneous melanoma that is amenable to surgical resection.


name: Adult Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

description: An acute myeloid leukemia with recurrent genetic abnormalities occurring in adults.


High Grade Liver Dysplastic Nodule

description: A hepatic dysplastic nodule characterized by the presence of high grade atypical cellular changes.


Sporadic Gastric Adenocarcinoma

description: A primary adenocarcinoma of the stomach in a patient with no family history of gastric cancer or inherited high risk mutations.


Subacute Placental Infarction

description: A focus of necrotic placental parenchyma with moderate hyalinization and fibrosis with partial absence of the necrotic chorionic villi, which is frequently 3-5 days of duration.


K ATP Permanent Neonatal Diabetes

description: K ATP channel-associated neonatal diabetes mellitus that does not resolve spontaneously.


Resectable Sarcoma

description: Sarcoma that is amenable to surgical resection.


description: Thrombotic microangiopathy of the gastrointestinal tract.


Accident

description: An unforeseen and unplanned event or circumstance frequently causing loss or injury.


name: Clinical Stage I Cutaneous Melanoma AJCC v8

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Advanced Adnexal Carcinoma

description: Adnexal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Endometrial cystic hyperplasia

description: Benign endometrial hyperplasia characterized by the presence of cystically dilated glands.


Childhood Skin Neoplasm

description: A benign, intermediate, or malignant neoplasm that affects the skin and occurs during childhood.


Imaging Finding

description: The result of an evaluation technique using a visual display of structural or functional patterns of organs or tissues that is performed to determine the presence, absence, or degree of a condition.


Meniscal Cyst

description: A cyst located at the periphery of the meniscus.


name: Malignant Lymphoma, Histiocytic, Diffuse


Papillary mucinous cystadenoma

description: A usually benign and less often low malignant potential cystic epithelial neoplasm composed of cells which contain intracytoplasmic mucin. It is characterized by the presence of papillary structures.


name: Acute gonococcal infection of lower genitourinary tract

description: A gonococcal infection of the lower urinary tract that is rapid in onset.


name: Musculoskeletal Chest Pain due to Rib Injury

description: A condition in which there is musculoskeletal chest pain secondary to trauma to one or more ribs. (ACC/AHA)


Parathyroid Clear Cell Hyperplasia

description: A hyperplasia of the clear cells of the parathyroid gland.


Paradental Cyst

description: An inflammatory collateral cyst that arises on the lower third molars. (WHO 2017)


name: FIGO Stage II Gestational Trophoblastic Tumor

description: Lesion invades outside of the uterus, but it is limited to the genital structures.


Malignant Paraganglionic Neoplasm

description: A paraganglioma that metastasizes to regional or distant anatomic sites.  Extraadrenal paragangliomas have a higher tendency to metastasize, as compared to pheochromocytomas.  Common sites of metastasis include the lymph nodes, lungs, bones, and liver.


name: Psychotic disorder due to a general medical condition

description: A psychotic disorder characterized by prominent hallucinations or delusions that have been determined to be etiologically linked to a general medical condition.


Stage II Prostate Cancer AJCC v7

description: Stage II includes: IIA (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X); IIB (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  T2c: Tumor involves both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


Stage IV Cervical Cancer FIGO 2018

description: The cervical carcinoma has extended beyond the true pelvis or has involved (biopsy proven) the mucosa of the bladder or rectum. (A bullous edema, as such, does not permit a case to be allotted to Stage IV). (FIGO 2018)


Encephalopathy of Prematurity

description: A condition affecting premature infants characterized by white matter injury, which is frequently accompanied by neuronal/axonal disease, that may affect all brain parenchymal structures and is due to a combination of destructive processes as well as maturational and trophic disturbances.


Metastatic Bladder Adenocarcinoma

description: Bladder adenocarcinoma that has spread from its original site of growth to other anatomic sites.


Severe Aplastic Anemia

description: Life-threatening anemia associated with a high risk of infection or bleeding.


name: Refractory Extracranial Malignant Solid Neoplasm

description: An extracranial malignant solid neoplasm that is resistant to treatment.


Flat adenoma

description: An adenoma of the gastrointestinal tract mucosa which grossly and morphologically does not appear as an elevated or polypoid lesion.


name: Pathologic Stage III Esophageal Adenocarcinoma AJCC v8

description: Stage III includes: IIIA: (T1, N2, M0, Any G); (T2, N1, M0, Any G); IIIB: (T2, N2, M0, Any G); (T3, N1-2, M0, Any G); (T4a, N0-1, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Adult Solid Neoplasm

description: A solid neoplasm (e.g., carcinoma, sarcoma) occurring in adults.


Early Stage Endometrial Carcinoma

description: A stage term referring to endometrial carcinoma that is confined to the uterus.


name: Ampulla of Vater Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of an ampulla of Vater neuroendocrine tumor according to the American Joint Committee on Cancer, 8th edition. This staging system applies to well-differentiated neuroendocrine tumors of the ampulla of Vater. Carcinomas of the ampulla of Vater, including high-grade (grade 3), poorly differentiated neuroendocrine carcinomas are not included in this staging system. (from AJCC 8th Ed.)


name: Sustained Atrial Tachyarrhythmia Related to COVID-19 other than Atrial Fibrillation or Atrial Flutter

description: A supraventricular tachycardia, including AV nodal re-entry, orthodromic re-entrant tachycardia, multifocal atrial tachycardia, other atrial tachycardia that lasts more then 30 seconds in a patient with probable or confirmed acute COVID-19.


name: Ductal Eccrine Carcinoma with Spindle Cell Elements

description: A variant of ductal eccrine carcinoma with spindled cell appearance.


Pancreatic carcinoma recurrent

description: The reemergence of pancreatic carcinoma after a period of remission.


Seropositive rheumatoid arthritis

description: Rheumatoid arthritis in which a patient's serum is positive for certain disease-related antibodies including anti-cyclic citrullinated peptides (anti-CCPs), also called anti-citrullinated protein antibodies (ACPAs),and rheumatoid factor (RF). Screening for anti-CCPs is more specific than RF which can be found in other pathologic conditions. The production of these disease-associated antibodies may precede the development of clinical symptoms by several years. Seropositive patients have a greater likelihood of developing extra-articular complications and a more severe course of disease.


Spitzoid melanoma

description: A cutaneous melanoma that is associated with genomic alterations observed in Spitz nevus and Spitz melanocytoma. It shares histopathological and clinical features with Spitz melanocytoma.


Acquired Rickets

description: Rickets that is caused by vitamin D deficiency, hypocalcemia, or renal failure.


Diffuse Glioma

description: A glioma that has diffusely infiltrated the surrounding central nervous system tissues.


Acquired Phrenic Nerve Injury

description: Damage to the phrenic nerve that was not present at birth.


name: Vulvar Squamous Intraepithelial Lesion, HPV-Associated

description: An intraepithelial lesion of the vulvar squamous epithelium associated with HPV infection. It is characterized by maturation abnormalities and nuclear hyperchromasia that are confined to the basement membrane.


name: Pathologic Stage IC Esophageal Adenocarcinoma AJCC v8

description: Stage IC includes: (T1, N0, M0, G3); (T2, N0, M0, G1-2). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. G2: Moderately differentiated. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


name: Rhabdomyosarcoma with TFCP2 Rearrangement

description: An aggressive, high-grade rhabdomyosarcoma characterized by TFCP2 rearrangement that results either in TFCP2-FUS or TFCP2-EWSR1 fusion gene formation. It affects young adults and arises from bone and less frequently soft tissue. It predominantly affects the craniofacial bones. Histologically, it usually shows a biphasic pattern with spindle and epithelioid cell areas. It is associated with poor prognosis.


name: Childhood Mixed Cellularity Classic Hodgkin Lymphoma

description: Mixed cellularity classic Hodgkin lymphoma occurring in childhood.


Cebocephaly

description: A congenital abnormality characterized by a malformation of the head. The eyes are hypoteleric and the nose may be absent or misshapen (small, flattened, single nostril) and defective.


Stage I Skin Cancer

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  High-risk features for the primary tumor staging are defined as follows: depth/invasion of more than 2 mm thickness, Clark level equal or greater than IV, and perineural invasion.  Anatomic location: primary site ear and primary site non-hair-bearing lip.  Differentiation: poorly differentiated or undifferentiated.  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th ed.)


Eyelid Function Disorder

description: A disorder characterized by impaired eyelid function.


Stage IVB Prostate Cancer AJCC v8

description: Stage IVB includes: Any T, N0, M1, PSA: Any, Grade Group: Any. N0: Prostate cancer with no positive regional nodes. M1: Prostate cancer with distant metastasis. (AJCC 8th ed.)


Stage IIC Testicular Cancer AJCC v8

description: Stage IIC includes: (Any pT/TX, N3, M0, S0); (Any pT/TX, N3, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Breast Columnar Cell Lesion

description: A morphologic spectrum of lesions that arise in the terminal ductal lobular units of the breast parenchyma.  These lesions are characterized by the presence of columnar epithelial cells that line dilated terminal ductal lobular units.  Cytological and architectural atypia may be absent or minimal, or significant enough to raise the possibility of atypical ductal hyperplasia or ductal carcinoma in situ.  Columnar cell lesions are frequently found in breast biopsies but their biologic significance is not known.


name: Lugano Classification Stage III Adult Hodgkin Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Pre-Gestational Diabetes

description: Diabetes diagnosed before current pregnancy. (reVITALize)


Type II Endometrial Adenocarcinoma

description: A classification of primary endometrial adenocarcinomas that refers to clear cell adenocarcinoma, serous adenocarcinoma, and serous endometrial intraepithelial carcinoma.


Degenerated Schwannoma

description: A schwannoma that is characterized by degenerative changes such as hyalinization, hemorrhage, calcification and cystic change.


name: Advanced Digestive System Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from any part of the digestive system and has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Unresectable Midgut Neuroendocrine Tumor

description: A midgut neuroendocrine tumor that is not amenable to surgical resection.


Factor II Inactivation

description: Presence of inactivating antibodies to prothrombin (factor II) in the blood.


name: Pathologic Stage IB Esophageal Adenocarcinoma AJCC v8

description: Stage IB includes: (T1a, N0, M0, G2); (T1b, N0, M0, G1-2); (T1b, N0, M0, GX). T1a: Tumor invades the lamina propria or muscularis mucosae. T1b: Tumor invades the submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. G2: Moderately differentiated. (AJCC 8th ed.)


name: Fetus Small for Gestational Age with Abnormal Doppler

description: A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and has abnormal Doppler studies.


name: Metastatic squamous cell carcinoma to skin

description: A squamous cell carcinoma that has spread to the skin from another anatomic site.


name: Peripheral neuropathy due to and following antineoplastic therapy

description: Any disorder affecting the peripheral nerves resulting from exposure to chemotherapeutic agents.


Finding

description: Clinical, laboratory or molecular evidence, or absence of evidence of disease.


name: Type I Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the superior vena cava.


Recurrent Diffuse Midline Glioma

description: The reemergence of diffuse midline glioma after a period of remission.


Childhood Solid Neoplasm

description: A solid neoplasm (e.g., carcinoma, sarcoma) occurring in children.


Metastatic Low Grade Glioma

description: Low grade glioma that has spread from its primary site to another anatomic site.


Unresectable Diffuse Glioma

description: A diffuse glioma that is not amenable to surgical resection.


name: Substance-Induced Persisting Amnestic Disorder

description: A disorder involving memory impairment (either anterograde or retrograde) that is etiologically linked to the persisting effects of substance use. The memory impairment persists beyond the usual duration of substance intoxication or withdrawal.


Platinum-Resistant Urothelial Carcinoma

description: Urothelial carcinoma that is resistant to platinum therapy.


Liver Lymphangiomatosis

description: Multiple lymphangiomas that affect the liver and other anatomic sites. Although histologically benign, diffuse lymphangiomatosis that affects the liver and multiple organs has a poor prognosis.


name: Supratentorial Ependymoma, Not Otherwise Specified

description: A circumscribed ependymoma that arises from the supratentorial region of the brain in which the genetic analysis for fusion genes involving ZFTA or YAP1 genes was unsuccessful or not reported.


Stage II Merkel Cell Carcinoma AJCC v7

description: Stage II includes: IIA: (T2/T3, pN0, M0), IIB: (T2/T3, cN0, M0), and IIC: (T4, N0, M0).  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  T4: Primary tumor invades bone, muscle, fascia, or cartilage.  pN0: No regional lymph node metastasis by pathologic examination.  cN0: No regional lymph node metastasis by clinical examination.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Mixed subtype adenocarcinoma of lung

description: The most frequently seen morphologic variant of lung adenocarcinoma characterized by a mixture of architectural patterns, including acinar, papillary, bronchioloalveolar, and solid pattern.


Vital Exhaustion

description: A condition characterized by excessive fatigue and lack of energy, increasing irritability, and feelings of demoralization. Persons who experience this condition are not at an increased risk for cancer.


Hemorrhagic cyst

description: A cyst containing blood.


name: Recurrent Anal Canal Squamous Cell Carcinoma

description: The reemergence of anal canal squamous cell carcinoma after a period of remission.


Stage IIA1 Cervical Cancer FIGO 2009

description: Cervical carcinoma limited to the upper two-thirds of the vagina and is equal or less than 4 cm in diameter. (FIGO 2009)


Non-Neoplastic Muscle Disorder

description: A non-neoplastic disorder that affects the smooth, skeletal, or cardiac muscles.


name: Stage III Extragonadal Non-Seminomatous Germ Cell Tumor


Vaginal Adenoid Basal Carcinoma

description: A carcinoma that arises from the vagina and is characterized by the presence of nests of basaloid cells with focal glandular formations.


Retinoblastoma by AJCC v8 Stage

description: A term that refers to the staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition. This staging system does not apply to central nervous system component of "trilateral retinoblastoma" (is staged according to the classification for brain and spinal cord), retinoma (or retinocytoma) (no AJCC staging system), and medulloepithelioma (no AJCC staging system). (from AJCC 8th Ed.)


name: Gallbladder Intracholecystic Papillary (Tubular) Neoplasm with Intermediate Grade Intraepithelial Neoplasia

description: An intracholecystic papillary neoplasm that arises from the epithelium of the gallbladder. It is characterized by the presence of moderate epithelial atypia.


name: Unresectable Distal Esophagus Adenocarcinoma

description: Distal esophagus adenocarcinoma that is not amenable to surgical resection.


Thoracoschisis

description: A congenital fissure of the thoracic wall.


name: Intraepithelial Neoplasia in Barrett Esophagus

description: Glandular intraepithelial neoplasia arising in Barrett esophagus.


Small plaque parapsoriasis

description: A variant of parapsoriasis in which the plaques are small.


name: Advanced Digestive System Neuroendocrine Tumor G2

description: Digestive system neuroendocrine tumor G2 that has spread extensively to other anatomic sites or is no longer responding to treatment.


Gallbladder Cribriform Carcinoma

description: A rare variant of gallbladder adenocarcinoma.  It is characterized by the presence of a malignant glandular epithelial infiltrate with a cribriform growth pattern.


name: Accelerated Phase Myeloproliferative Neoplasm

description: Rapid progression of a myeloproliferative neoplasm, characterized by the presence of myeloblasts accounting for 10-19% of the peripheral blood white cells or the nucleated cells in the bone marrow.


name: Refractory EBV-Related Lymphoproliferative Disease with Primary Immunodeficiency

description: EBV-associated lymphoproliferative disease with primary immunodeficiency that is resistant to treatment.


Overt Primary Myelofibrosis

description: Primary myelofibrosis characterized by reticulin or collagen fibrosis in the bone marrow. The bone marrow is usually normocellular or hypocellular. Myeloblasts account for less than 10% of the bone marrow cells. Atypical megakaryocytes are present.


Radiating Chest Pain in Sternum

description: The location of the radiating chest pain is in the middle of the anterior wall of the thorax, bounded by the clavicles, above, and with the cartilages of the first seven ribs, along the sides.


name: Stage IIIC2 Uterine Corpus Cancer AJCC v7

description: Stage IIIC2 includes: T1-T3, N2, M0. T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue.  N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Tumor Pain

description: A painful sensation caused by the tumor growth.


Acute Myeloid Leukemia with del(12p)

description: Acute myeloid leukemia associated with deletion of the short arm of chromosome 12 [del(12p)].


Mucosal-Dominant Pemphigus Vulgaris

description: A subtype of pemphigus vulgaris in which lesions are predominantly found on mucosal membranes with relative sparing of cutaneous tissues.


Metastatic Biliary Tract Carcinoma

description: A biliary tract carcinoma that has spread from the original site of growth to other anatomic sites.


Cervical Glandular Neoplasm

description: A benign, malignant, or precancerous neoplasm that arises from the glandular epithelium of the cervix. Representative examples include endocervical polyp, cervical adenocarcinoma, and cervical glandular intraepithelial neoplasia.


name: Metastatic Bladder Micropapillary Urothelial Carcinoma

description: Bladder micropapillary urothelial carcinoma that has spread to another anatomic site.


name: Lugano Classification Advanced Stage Adult Hodgkin Lymphoma AJCC v8

description: Advanced stage adult Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


Stage IIA Cervical Cancer FIGO 2018

description: Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement. (FIGO 2018)


Behavioral insomnia of childhood

description: A childhood disorder characterized by difficulty initiating and maintaining sleep due to negative sleep associations, refusal to go to bed, and/or repeated attempts to delay bedtime.


name: Malignant Central Nervous System Germ Cell Tumor

description: A germ cell tumor that affects the central nervous system, characterized by the presence of malignant morphologic characteristics.  Representative examples include choriocarcinoma, embryonal carcinoma, and germinoma.


Hodgkin's lymphoma of CNS

description: A Hodgkin lymphoma that arises from the central nervous system.


Vaginal Mucinous Adenocarcinoma

description: A rare adenocarcinoma that arises from the vagina with histologic features resembling cervical mucinous adenocarcinoma.


Posterior Subcapsular Cataract Grade 1

description: A stage of posterior subcapsular cataract characterized by 3% of the posterior capsule obscured by opacity. (Modified LOCS II)


Infant Acute Lymphoblastic Leukemia

description: An acute lymphoblastic leukemia that occurs in infancy.


name: Simple Endometrial Hyperplasia without Atypia

description: A proliferation of endometrial cells resulting in glandular enlargement and budding without changes in the basic structure of the endometrium. Epithelial atypia is absent.


name: Locally Advanced Epithelioid Hemangioendothelioma

description: An epithelioid hemangioendothelioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Neonatal Deformity

description: A congenital anatomic abnormality manifested during the neonatal period.


name: Stage IIIB Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of lymph node regions on both sides (above and below) of the diaphragm. This may be accompanied by extra-lymphatic extension in association with adjacent lymph node involvement (i.e., local extension from a lymph node area into a nearby organ) and/or involvement of spleen. The medical record states there are constitutional symptoms. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Breast Papillary Ductal Hyperplasia

description: Benign papillary proliferation within the ductal system of the breast parenchyma.


Benign Urinary Tract Neoplasm

description: A neoplasm that arises from the organs that comprise the urinary tract and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Somatic-Type Malignancy

description: A malignant non-germ cell component that typically develops secondarily within a germ cell tumor. The malignant cellular component is usually sarcomatous or carcinomatous.


Stage IIB Pancreatic Cancer AJCC v8

description: Stage IIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. N1: Metastasis in one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Non-Neoplastic Thymus Disorder

description: A non-neoplastic disorder that affects the thymus.  Representative examples include acute thymic involution and thymic hyperplasia.


name: Postoperative Spindle Cell Nodule of the Bladder

description: A benign, reactive lesion of the bladder, occurring status post bladder instrumentation; histologic exam demonstrates a fascicular growth pattern of plump or elongated spindle cells infiltrating the bladder wall without atypia or necrosis.


Microinvasive Anal Carcinoma

description: Anal carcinoma with minimal stromal invasion.


Subgaleal hemorrhage

description: Bleeding between the scalp and the periosteum.


Melanoma of Unknown Primary

description: A melanoma which has metastasized from an unknown primary anatomic site.


Unresectable Malignant Neoplasm

description: A malignant neoplasm which is not amenable to surgical resection.


Stage IV Osteosarcoma AJCC v7

description: Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Neonatal apneic attack

description: Apnea occurring during the neonatal period.


name: Locally Advanced Pancreatic Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IIIB Appendix Carcinoma AJCC v7

description: Stage IIIB includes: (T3, N1, M0); (T4, N1, M0). T3: Tumor invades through the muscularis propria into subserosa or into mesoappendix.  T4: Tumor penetrates visceral peritoneum including mucinous peritoneal tumor within the right lower quadrant and/or directly invades other organs or structures.  N1: Metastasis in 1-3 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Dialysis Catheter Embolism

description: An obstruction of a vessel caused by a detached fragment of an indwelling dialysis catheter.


name: Pathologic Stage 0 Cutaneous Melanoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Fusion-Negative Rhabdomyosarcoma

description: A rhabdomyosarcoma characterized by the absence of chromosomal translocation t(1;13)(p36;q14) or t(2;13)(q35;q14) and therefore the absence of PAX7-FOXO1 or PAX3-FOXO1 gene fusion.


name: Metastatic Bladder Squamous Cell Carcinoma

description: Bladder squamous cell carcinoma that has spread to another anatomical site.


name: Transplant-Related Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises in a patient with a history of organ transplantation.


Refractory Anaplastic Oligodendroglioma

description: An anaplastic oligodendroglioma that is resistant to treatment.


Reinfection

description: A second infection by the same pathogen that follows a period of recovery.


Immunotoxicity

description: Toxicity that impairs or damages the immune system.


name: Acute Myeloid Leukemia with Mutated TP53

description: Acute myeloid leukemia characterized by the presence of TP53 gene mutations. There are 20% or more blasts in bone marrow or peripheral blood.


Accessory Urethral Gland Neoplasm

description: A benign or malignant, primary or metastatic neoplasm affecting the accessory urethral gland.


Stage II Gallbladder Cancer AJCC v6

description: Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N0, M0); (T2, N0, M0); (T3, N0, M0).  T2: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, or pancreas, omentum or extrahepatic bile ducts. (AJCC 6th ed.)


name: Ampulla of Vater Undifferentiated Carcinoma

description: An aggressive carcinoma arising from the ampulla of Vater.  Morphologically, it is characterized by the presence of malignant epithelial cells without evidence of glandular or squamous differentiation.  Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss.


name: Clinical Stage II Retinoblastoma AJCC v8

description: Stage II includes: cT4a, cN0, cM0, Any H. cT4a: Radiologic evidence of retrobulbar optic nerve involvement or thickening of optic nerve or involvement of orbital tissues. cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Peripheral Hemangioblastoma

description: A hemangioblastoma that arises from peripheral nerves or extraneural tissues.


Non-Ossifying Fibroma

description: A tumor histologically indistinguishable from, but larger than, benign fibrous histiocytoma of bone.


Digitalis toxicity

description: Acute CNS, visual, GI, and cardiac disturbances caused by an overdose of, or intolerance to, the cardiac glycoside, digitalis.


name: Hodgkin's Paragranuloma Involving Spleen

description: An obsolete term that includes cases currently classified as nodular lymphocyte predominant Hodgkin lymphoma with splenic involvement.


Stage IB1 Cervical Cancer AJCC v8

description: Stage IB1 includes: T1b1, Any N, M0. T1b1: Tumor with clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Cervical Cancer AJCC v8

description: Stage IIA includes: T2a, Any N, M0. T2a: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


Liver Radiation Injury

description: Radiation injury of the liver.


BRCA-Associated Malignant Neoplasm

description: A malignant neoplasm caused by deleterious germline mutation in a gene of the BRCA family.


name: Recurrent Low Grade Endometrioid Adenocarcinoma

description: The reemergence of low-grade endometrioid adenocarcinoma after a period of remission.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Tier 1, International Society of Pediatric Oncology (SIOP) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the tier 1 Toronto childhood cancer staging guidelines v2, International Society of Pediatric Oncology (SIOP) protocol.


Benign Apocrine Neoplasm

description: An epithelial neoplasm that arises from the apocrine glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Non-Neoplastic Tracheal Disorder

description: A non-neoplastic disorder that affects the trachea.  Representative examples include tracheitis, tracheal agenesis, and tracheal atresia.


Gastroblastoma

description: A very rare biphasic tumor arising in the gastric muscularis propria (usually of the antrum), generally in boys and young men. It is associated with MALAT1-GLI1 gene fusion. (WHO 2019)


Cheilognathoschisis

description: A congenital abnormality consisting of a fissure in the midline of the lip and upper jaw.


Villous Adenoma of the Urinary Tract

description: An exophytic glandular neoplasm of the urinary tract, morphologically similar to its intestinal counterpart. It usually arises from the bladder and urachus. It often coexists with in situ or infiltrating bladder adenocarcinoma.


Non-Neoplastic Axillary Disorder

description: A non-neoplastic disorder that affects the structures of the axilla.  Representative examples include axillary lymphadenitis and axillary abscess.


Primary Cutaneous NUT Adnexal Carcinoma

description: A very rare carcinoma that arises from adnexal structures in the skin. It is characterized by mutations and rearrangement of the NUT gene. It presents as a papular or nodular lesion and has been described in the hand, shoulder, trunk, and lower limb. Histologically, there is a proliferation of malignant epithelial cells in the dermis and/or subcutaneous tissue. The tumor cells display round nuclei with prominent single nucleoli. Features include the presence of small round ducts and foci of abrupt keratinization.


Hemoglobin Trait

description: A condition in which a person is heterozygous for a globin gene, with a one normal allele and one defective allele.


HIV lipodystrophy

description: A neoplastic process characterized by a diffuse poorly circumscribed overgrowth of adipose tissue in the breast and cervical areas, and an accumulation of visceral fat.  It is associated with antiretroviral therapy.  Clinical presentation includes hyperlipidemia, insulin resistance, and fat atrophy of the face and limbs.


Cortical Cataract Grade 1

description: A stage of cortical cataract characterized by 10% of the intrapupillary space obscured by opacity. (Modified LOCS II)


Stage I Uterine Corpus Cancer AJCC v6

description: Stage I includes: I (T1, N0, M0); IA: (T1a, N0, M0); IB (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor confined to corpus uteri. T1a: Tumor limited to the endometrium.  T1b: Tumor invades less than one-half of the myometrium.  T1c: Tumor invades one-half or more of the myometrium.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Acute synovitis

description: An acute inflammation of a synovial membrane. It is associated with swelling and pain in the affected area.


Stage IIB Anal Cancer AJCC v8

description: Stage IIB includes: T3, N0, M0. T3: Tumor larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Mucosal Melanoma

description: Mucosal melanoma that has spread from its primary site to another anatomic site.


name: Recurrent Childhood Anaplastic Oligodendroglioma

description: The reemergence of anaplastic oligodendroglioma in childhood after a period of remission.


name: Malignant neoplasm arising from pre-existing spiradenocylindroma

description: A carcinoma that arises in a spiradenocylindroma.


name: Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with High Grade Dysplasia

description: An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized by the presence of high grade dysplasia.


Lithium Induced Birth Defect

description: Congenital abnormalities, mainly cardiovascular malformations, which develop in a fetus when the mother uses lithium medication during pregnancy.


Hematologic Toxicity

description: A toxicity that impairs or damages the hematologic system.


name: Metastatic Vaginal Squamous Cell Carcinoma

description: Vaginal squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


name: Platinum-Refractory Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that progresses during platinum therapy or within one month of completing platinum therapy.


Factor XII Inactivation

description: Presence of inactivating antibodies to factor XII in the blood.


name: Papillary cystadenoma, borderline malignancy

description: A serous or mucinous cystic glandular epithelial neoplasm of low malignant potential. It is characterized by the presence of atypical or malignant glandular epithelial cells forming papillary structures with an absence of stromal invasion.


Toxicity due to Psychiatric Drugs

description: Toxicity that develops due to the administration of psychiatric medications.


name: Metastatic Unresectable Malignant Neoplasm

description: A malignant neoplasm that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


name: Benign Outer Hair Sheath and Infundibulum Neoplasm

description: A neoplasm that arises from the outer hair sheath and infundibulum. It is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Female Reproductive System Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle neoplasm that arises from any part of the female reproductive system and cannot be reliably diagnosed as benign or malignant because of the presence of ambiguous morphologic findings.


Non-Neoplastic Splenic Disorder

description: A non-neoplastic disorder that affects the spleen.


SUR1-Associated Diabetes Mellitus

description: Diabetes mellitus caused by activating mutation(s) in the ABCC8 gene, encoding the sulfonylurea receptor 1 (SUR1) subunit of the pancreatic beta cell adenosine triphosphate-sensitive potassium channel. Note: Inactivating mutation(s) in the ABCC8 gene result in hyperinsulinism.


name: Stage II Adult Diffuse Large Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Acute Myeloid Leukemia with del(5q)

description: Acute myeloid leukemia associated with deletion of the long arm of chromosome 5 [del(5q)].


Stabbing Pain

description: An intense sensation of discomfort or distress that is sharp and feels as though a knife has penetrated an anatomical location.


Tissue Rarefaction

description: A morphologic finding indicating reduced tissue density.


name: Acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22) CBFB-MYH11

description: An acute myeloid leukemia with monocytic and granulocytic differentiation and the presence of a characteristically abnormal eosinophil component in the bone marrow.  This type of acute myeloid leukemia has a favorable prognosis.  (WHO, 2001)


name: Mucosal Melanoma of the Female Genital Tract

description: A malignant melanocytic neoplasm that arises from a mucosal site of the female genital tract.


Perineal Pain

description: Painful sensation in the perineal area.


name: immune effector cell-associated neurotoxicity syndrome, grade 1

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 7, 8, or 9 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of less than 9 (for children 12 and under), and the ability of the affected individual to awaken spontaneously.


name: Metastatic Extracranial Malignant Solid Neoplasm

description: A malignant solid neoplasm that arises from any anatomic site other than the brain and has spread from its original site of growth to another anatomic site.


name: Gestational Trophoblastic Tumor by FIGO Stage


name: IgG4-Positive Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: A primary cutaneous marginal zone lymphoproliferative disorder characterized by the presence of class-switched immunoglobulin heavy chain expressing IgG4.


name: Transitional Cell Intraepithelial Neoplasia


Abscess of axilla

description: A collection of pus that has formed in the axilla.


Atheroembolism of renal arteries

description: A cholesterol plaque embolus that has become lodged in the renal vasculature.