20q11.2 microdeletion syndrome

description: 20q11.2 microdeletion syndrome is a rare, genetic, syndromic intellectual disability characterized by psychomotor delay, hypotonia, feeding difficulties, failure to thrive, anomalies of the hands and feet (clinodactyly, camptodactyly, brachydactyly, feet malposition), and craniofacial dysmorphism. Associated prenatal growth retardation, and gastrointestinal, heart and eye anomalies have been reported.


(S)-SKF 38393

A 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol that is the S-enantiomer of SKF 38393.


name: Resectable Clear Cell Renal Cell Carcinoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Clear cell renal cell carcinoma that is amenable to surgical resection.


Resectable Renal Cell Carcinoma

description: Renal cell carcinoma that is amenable to surgical resection.


urethral calculus

description: A concretion in the urethra.


TDP-43 proteinopathy

description: Disease characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.


cervicofacial actinomycosis

description: A form of actinomycosis characterized by slow-growing inflammatory lesions of the lymph nodes that drain the mouth (lumpy jaw), reddening of the overlying skin, and intraperitoneal abscesses.


4p16.3 microduplication syndrome

description: 4p16.3 microduplication syndrome is a rare genetic syndrome that results from the partial duplication of the short arm of chromosome 4. It has a highly variable phenotype, principally characterized by psychomotor and language delay, seizures and dysmorphic features such as high forehead with frontal bossing, hypertelorism, prominent glabella, long narrow palpebral fissures, low set ears and short neck. Eye abnormalities (glaucoma, irregular iris pigmentation, hyperopia) have also been reported.


Intraocular Infection

description: Infection within the eye.


Fungal endophthalmitis

description: Inflammation of the lining of the ocular cavities, which results from a fungal infection.


parasitic endophthalmitis

description: Infection of the epicondyles by a parasite.


cytomegalovirus retinitis

description: Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. Cytomegalovirus retinitis is a major opportunistic infection in aids patients and can cause blindness.


autoimmune vasculitis

description: An autoimmune form of vasculitis.


rheumatoid vasculitis

description: Necrotizing VASCULITIS of small and medium size vessels, developing as a complication in RHEUMATOID ARTHRITIS patients. It is characterized by peripheral vascular lesions, cutaneous ulcers, peripheral gangrene, and mononeuritis multiplex.


name: Benign Epithelial Melanoses of the Conjunctiva

description: A group of benign, non-neoplastic lesions in the conjunctiva characterized by increased production of melanin without proliferation of conjunctival melanocytes.


Recurrent Breast Acinic Cell Carcinoma

description: The reemergence of acinic cell breast carcinoma after a period of remission.


cranial nodular fasciitis

description: A rare self-limiting, rapidly growing, non-encapsulated benign neoplasm that arises from the cranium. This is an osteolytic lesion. It is characterized by the presence of plump spindle-shaped fibroblasts, multinucleated osteoclast-like giant cells, chronic inflammatory infiltrate, red blood cell extravasation, and high mitotic activity.


Stage V Kidney Wilms Tumor

description: Wilms tumor that affects both kidneys at the same time. The tumor in each kidney is staged separately (National Wilms Tumor Study Group Staging System)


name: thrombocytopenia 12 with or without myopathy


name: Adenocarcinoma in multiple adenomatous polyps

description: Adenocarcinomas developing in gastrointestinal tract adenomas in patients with multiple adenomatous polyps.


name: Adenocarcinoma in adenomatous polyposis coli

description: Adenocarcinomas developing in colorectal adenomas in patients with a history of adenomatous polyposis coli. The mean age of development of adenocarcinoma is about 40 years.


alcoholic psychosis

description: A group of mental disorders associated with organic brain damage and caused by poisoning from alcohol.


childhood parosteal osteosarcoma

description: A low grade malignant bone-forming mesenchymal neoplasm arising from the surface of the bone. It occurs in childhood and usually affects the distal posterior femur, the proximal tibia, and proximal humerus. Painless swelling is the usual clinical sign. The prognosis is usually excellent.


peripheral osteosarcoma

description: A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the surface of the bone.


high grade surface osteosarcoma

description: A usually aggressive high grade malignant bone-forming mesenchymal neoplasm arising from the surface of the bone.


Childhood Periosteal Osteosarcoma

description: A periosteal osteosarcoma occurring in childhood.


periosteal osteogenic sarcoma

description: An intermediate grade malignant bone-forming mesenchymal neoplasm with chondroblastic differentiation. It arises from the surface of the bone and affects the diaphysis or diaphyseal- metaphyseal portion of the long bones. A painless mass or swelling is the most common clinical sign. It is associated with a better prognosis than conventional osteosarcoma.


juxtacortical osteosarcoma

description: A low grade malignant bone-forming mesenchymal neoplasm arising from the surface of the bone. It usually affects the distal posterior femur, the proximal tibia, and proximal humerus. Painless swelling is the usual clinical sign. Most patients are young adults and the prognosis is usually excellent.


name: West Haven Hepatic Encephalopathy Grade 1

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Mild - symptoms or pathological characteristics include trivial lack of awareness, shortened attention span, impaired ability to perform addition or subtraction, hypersomnia, insomnia, or inversion of sleep pattern, euphoria, depression or irritability, mild confusion, slowing of ability to perform mental tasks. (Adapted from: Hepatic Encephalopathy. David C Wolf. http://emedicine.medscape.com/article/186101-overview.)


Dull Chest Pain

description: The sensation of chest pain described as a mild or blunted discomfort.


name: Recurrent Childhood Gemistocytic Astrocytoma

description: The reemergence of gemistocytic astrocytoma in childhood after a period of remission.


Recurrent Astrocytic Tumor

description: The reemergence of an astrocytic tumor after a period of remission.


name: Recurrent Childhood Cerebellar Astrocytoma

description: Regrowth of benign and malignant childhood cerebellar astrocytomas that have previously been subjected to surgical resection and less frequently other forms of therapy such as radiation or chemotherapy.  Recurrence of benign tumors (e.g., (pilocytic astrocytoma) may respond to a second surgical procedure.


name: Recurrent Childhood Pleomorphic Xanthoastrocytoma

description: The reemergence of pleomorphic xanthoastrocytoma in childhood after a period of remission.


Recurrent MGMT-Methylated Glioblastoma

description: The reemergence of MGMT-methylated glioblastoma after a period of remission.


name: Recurrent Childhood Anaplastic Astrocytoma

description: The reemergence of anaplastic astrocytoma in childhood after a period of remission.


name: Recurrent Anaplastic Pleomorphic Xanthoastrocytoma

description: The reemergence of anaplastic pleomorphic xanthoastrocytoma after a period of remission.


name: Recurrent Childhood Visual Pathway Astrocytoma

description: The reemergence of visual pathway astrocytoma in childhood after a period of remission.


Recurrent Childhood Astrocytic Tumor

description: The reemergence of a childhood astrocytic tumor after a period of remission.


name: Recurrent Childhood Cerebral Astrocytoma

description: The reemergence of cerebral astrocytoma in childhood after a period of remission.


name: Recurrent Anaplastic Astrocytoma, IDH-Wildtype

description: The reemergence of anaplastic astrocytoma, IDH-wildtype after a period of remission.


Recurrent Childhood Diffuse Astrocytoma

description: The reemergence of diffuse astrocytoma in childhood after a period of remission.


Recurrent Gliosarcoma

description: The reemergence of gliosarcoma after a period of remission.


Recurrent Childhood Glioblastoma

description: The reemergence of glioblastoma in childhood after a period of remission.


Recurrent Glioblastoma, IDH-Wildtype

description: The reemergence of glioblastoma, IDH-wildtype after a period of remission.


Recurrent Giant Cell Glioblastoma

description: The reemergence of giant cell glioblastoma after a period of remission.


Recurrent Anaplastic Astrocytoma

description: The reemergence of anaplastic astrocytoma after a period of remission.


name: Recurrent Childhood Pilomyxoid Astrocytoma

description: The reemergence of pilomyxoid astrocytoma in childhood after a period of remission.


Recurrent Astrocytoma, IDH-Mutant

description: The reemergence of IDH-mutant astrocytoma after a period of remission.


Recurrent Childhood Gliosarcoma

description: The reemergence of gliosarcoma in childhood after a period of remission.


name: Recurrent Childhood Giant Cell Glioblastoma

description: The reemergence of giant cell glioblastoma in childhood after a period of remission.


name: Recurrent Astrocytoma, IDH-Mutant, Grade 4

description: The reemergence of astrocytoma, IDH-mutant, Grade 4, after a period of remission.


Recurrent Diffuse Astrocytoma

description: The reemergence of diffuse astrocytoma after a period of remission.


name: Recurrent Childhood Subependymal Giant Cell Astrocytoma

description: The reemergence of subependymal giant cell astrocytoma in childhood after a period of remission.


name: Recurrent Childhood Pilocytic Astrocytoma

description: The reemergence of pilocytic astrocytoma in childhood after a period of remission.


Recurrent Glioblastoma

description: The reemergence of glioblastoma after a period of remission.


name: Recurrent Childhood Optic Nerve Astrocytoma

description: The reemergence of optic nerve astrocytoma in childhood after a period of remission.


Recurrent Small Cell Glioblastoma

description: The reemergence of small cell glioblastoma after a period of remission.


Recurrent Supratentorial Glioblastoma

description: The reemergence of supratentorial glioblastoma after a period of remission.


name: Recurrent Childhood Fibrillary Astrocytoma

description: The reemergence of fibrillary astrocytoma in childhood after a period of remission.


name: Recurrent Astrocytoma, IDH-Mutant, Grade 3

description: The reemergence of astrocytoma, IDH-mutant, grade 3 after a period of remission.


Recurrent Brain Glioblastoma

description: The reemergence of brain glioblastoma after a period of remission.


Recurrent Pilocytic Astrocytoma

description: The reemergence of pilocytic astrocytoma after a period of remission.


Recurrent Low Grade Astrocytoma

description: The reemergence of a low grade astrocytoma after a period of remission.


name: Recurrent Childhood Brain Stem Astrocytoma

description: The reemergence of brain stem astrocytoma in childhood after a period of remission.


description: A reactive cutaneous proliferation of macrophages. It is characterized by the presence of giant cells with ground-glass cytoplasm. It presents with multiple cutaneous or mucosal papules or nodules.


name: Epididymal Melanotic Neuroectodermal Tumor

description: A rare neoplasm that arises from the epididymis and is characterized by the presence of a mixture of melanin-containing epithelial cells and smaller neuroblast-like cells. It usually occurs in infants and has a benign clinical course.


name: brachydactyly, coloboma, and anterior segment dysgenesis


name: developmental delay with variable neurologic and brain abnormalities


facial nerve neoplasm

description: A neoplasm involving a facial nerve.


facial neuralgia

description: Neuralgic syndromes which feature chronic or recurrent facial pain as the primary manifestation of disease. Disorders of the trigeminal and facial nerves are frequently associated with these conditions.


geniculate ganglionitis

description: Diseases of the facial nerve or nuclei. Pontine disorders may affect the facial nuclei or nerve fascicle. The nerve may be involved intracranially, along its course through the petrous portion of the temporal bone, or along its extracranial course. Clinical manifestations include facial muscle weakness, loss of taste from the anterior tongue, hyperacusis, and decreased lacrimation.


geniculate herpes zoster

description: A viral ear infection caused by the spread of varicella-zoster virus to the facial nerves. It is characterized by intense otalgia and a cutaneous vesicular eruption.


name: Moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome

description: This syndrome is characterized by the association of Moebius syndrome (congenital facial palsy with impaired ocular abduction) with peripheral axonal neuropathy and hypogonadotropic hypogonadism.


NIK deficiency

description: A immunodeficiency disorder caused by loss of function mutation in NIK (MAP3K14).


transient retinal arterial occlusion

description: A partial, temporary occlusion of the retinal artery.


Hepatic Arterial Occlusion

description: An occlusion of the hepatic artery.


Efferent Arteriolar Hyalinosis

description: The deposition of hyaline material in the wall of the efferent arterioles.


Vertebral Artery Dissection

description: A tear within the wall of a vertebral artery.


Dissection of renal artery

description: A tear within the wall of a renal artery.


Dissection, Thoracoabdominal Aorta

description: A tear within the wall of the thoracoabdominal aorta.


Dissection, Thoracic Aorta

description: A tear within the wall of the thoracic aorta.


Juvenile polyarteritis

description: Polyarteritis occurring in children or adolescents.


Systemic Arterial Hypertensive Disorder

description: Any condition resulting in systemically elevated blood pressure that is attributed to an arterial source.


coronary atherosclerosis

description: Atherosclerosis of the coronary vasculature.


Three Vessel Coronary Disease

description: There was greater than or equal to 50% stenosis (reduction in cross-sectional area) in three coronary arteries (or greater than or equal to 50% stenosis in the left main coronary artery and greater than or equal to 50% stenosis in the right coronary artery). (ACC)


Dissection of iliac artery

description: A tear within the wall of an iliac artery.


generalized atherosclerosis

description: Atherosclerosis that is not localized.


arterial occlusion

description: Complete closure of the normally patent lumen of the blood vessels which carry blood away from the heart.


partial arterial retinal occlusion

description: A partial occlusion of the retinal artery.


Infectious Arteritis

description: A bacterial or viral infectious process affecting an artery.


Overlap Necrotizing Arteritis

description: A necrotizing arteritis that exhibits characteristic features of several distinct vascular disorders.


Necrotizing Arteritis

description: An arteritis characterized by the presence of inflammation and necrosis in the arterial wall.


microscopic polyangiitis

description: Microscopic polyangiitis (MPA) is an inflammatory, necrotizing, systemic vasculitis that affects predominantly small vessels (i.e. small arteries, arterioles, capillaries, venules) in multiple organs.


Double coronary vessel disease

description: There was greater than or equal to 50% stenosis (reduction in cross-sectional area) in two coronary arteries (or greater than or equal to 50% stenosis in the left main coronary artery). (ACC)


cerebral atherosclerosis

description: Atherosclerosis of the cerebral vasculature.


arteriolosclerosis

description: The thickening of the wall of the small arteries and arterioles. It is caused by deposition of hyaline material in the wall or concentric smooth muscle wall hypertrophy. It results in lumen narrowing and tissue ischemia.


Monckeberg arteriosclerosis

description: A type of arteriosclerosis in which calcification of the tunica media is the predominant feature.


One Vessel Coronary Disease

description: There was greater than or equal to 50% stenosis (reduction in cross-sectional area) in one coronary artery. (ACC)


cutaneous polyarteritis nodosa

description: Cutaneous polyarteritis nodosa (CPAN) is a rare limited form of polyarteritis nodosa (PAN), characterized by cutaneous vasculitis and mild and transient extracutaneous manifestations such as mild arthralgia, arthritis,myalgia, and rarely peripheral neuropathy.


Generalised arteriosclerosis

description: Arteriosclerosis that is not localized.


Significant Arterial Dissection

description: A dissection that impairs flow. This includes Type C (a persisting contrast medium extravasation) in the presence of ischemia, Type D (a spiral filling defect with delayed but complete distal flow), Type E (persistent filling defect with delayed antegrade flow) and Type F (filling defect with impaired flow and total occlusion).


Hyaline arteriolosclerosis

description: The deposition of hyaline material in the wall of the arterioles.


granulomatous angiitis

description: Inflammation of the arteries that is characterized by the presence of granulomas.


Femoropopliteal Occlusive Disease

description: An occlusive disease of the femoropopliteal vascular system.


endarteritis

description: Inflammation of the arterial intima.


Lung Radiation Injury

description: Radiation injury of the pulmonary system.


middle ear cholesterol granuloma

description: As accumulation of granulation tissue in the middle ear that results from the degeneration of blood and a chronic inflammatory response.


Bronchospasm, Exercise-Induced

description: Sudden contraction of the smooth muscles of the bronchial wall that occurs during or following exercise.


name: Drug-induced cutaneous lupus erythematosus

description: A reaction to a drug characterized by skin findings common to lupus including photosensitivity and butterfly rash; typically it resolves after drug discontinuation.


lupus erythematosus tumidus

description: Tumid erythematosus lupus is considered a rare type of chronic cutaneous lupus erythematosus. Cutaneous lupus erythematosus (CLE) can be divided into acute cutaneous lupus, subacute cutaneous lupus, and chronic cutaneous lupus. Tumid erythematosus lupus is characterized by smooth, non-scarring, pink- to violet-colored pimples (papules)on the skin without any other apparent skin changes, such as scarring. Patients with tumid lupus erythematosus usually do not have other symptoms of systemic lupus erythematosus or other types of cutaneous lupus erythematosus. The papules appear on sun-exposed areas of the face, upper back, V area of the neck, trunk, and arms, and more rarely on thighs and legs. They usually affect equally both sides of the body, but may affect only one side. Normally, the papules clear without leaving scars. The treatment is very effective in most cases, and may include sun protection, anti-malarials drugs, local corticosteroids, topical tacrolimus and light therapy.


Systemic lupus erythematosus rash

description: A rash associated with systemic lupus erythematosus.


subacute cutaneous lupus erythematosus

description: Subacute cutaneous lupus erythematosus (SCLE) is a form of cutaneous lupus erythematosus (CLE) that can present either as a non-scarring, annular photo-distributed dermatosis or psoriasiform plaques. SCLE is associated with anti-Ro/SSA antibodies and can be drug-induced.


L-5-monosubstituted hydantoin

Any imidazolidine-2,4-dione that bears a single substituent at position 5 and has L-configuration.


An L-5-monosubstituted hydantoin in which the substituent is specified as 2-(methylthio)ethyl.


name: Childhood Clear Cell Sarcoma of Soft Parts

description: A clear cell sarcoma of soft tissue occurring in children.


name: Metastatic Clear Cell Sarcoma of Soft Tissue

description: A clear cell sarcoma of soft tissue that has spread from the original site of growth to other anatomic sites.


name: Advanced Clear Cell Sarcoma of Soft Tissue

description: A clear cell sarcoma of soft tissue that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Recurrent Clear Cell Sarcoma of Soft Tissue

description: The reemergence of clear cell sarcoma of soft tissue after a period of remission.


name: Refractory Clear Cell Sarcoma of Soft Tissue

description: Clear cell sarcoma of soft tissue that is resistant to treatment.


name: primary cutaneous gamma/delta-positive T-cell lymphoma

description: Primary cutaneous gamma/delta-positive T-cell lymphoma is a rare, usually aggressive, subtype of cutaneous T-cell lymphoma characterized by infiltration of the epidermis, dermis or subcutaneous tissue by a clonal population of mature, gamma/delta positive cytotoxic T-cells. Typically it presents with ulcerating plaques, tumors, or subcutaneous nodules on the skin of the extremities, however, frequent involvement of mucosal and extranodal sites (such as the nasal cavity, gastrointestinal tract or lungs) is also observed. Cases associated with panniculitis may present with hemophagocytic syndrome (abrupt onset of fever, rash, cytopenia, hepatosplenomegaly and neurological compromise). Infiltration of lymph nodes, spleen and bone marrow is uncommon and resistance to multilineage chemotherapy is reported.


name: prolonged electroretinal response suppression 2


name: Locally Advanced Unresectable Gastric Adenocarcinoma

description: A gastric adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Metastatic Unresectable Carcinoma

description: A carcinoma that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


name: Metastatic Unresectable Basal Cell Carcinoma

description: A basal cell carcinoma that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


name: Locally Advanced Unresectable Esophageal Adenocarcinoma

description: Esophageal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Digestive System Adenocarcinoma

description: Digestive system adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Gastroesophageal Junction Adenocarcinoma

description: Gastroesophageal junction adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Pancreatic Adenocarcinoma

description: A pancreatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Metastatic Unresectable Gastric Adenocarcinoma

description: A gastric adenocarcinoma that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


name: Locally Advanced Unresectable Triple-Negative Breast Carcinoma

description: Triple-negative breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Colon Adenocarcinoma

description: A colon adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Basal Cell Carcinoma

description: A basal cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Carcinoma

description: A carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Prostate Adenocarcinoma

description: A prostatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Breast Carcinoma

description: A breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Unresectable Castration-Resistant Prostate Carcinoma

description: Castration-resistant prostate carcinoma that is not amenable to surgical resection.


name: Locally Advanced Unresectable Renal Cell Carcinoma

description: A renal cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Colorectal Adenocarcinoma

description: A colorectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable HER2-Negative Breast Carcinoma

description: A HER2-negative breast adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Cervical Adenocarcinoma

description: A cervical adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Lung Non-Small Cell Squamous Carcinoma

description: A non-small cell squamous carcinoma of the lung that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable HER2-Positive Breast Carcinoma

description: HER2-positive breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma

description: Hormone receptor-positive breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Prostate Carcinoma

description: A prostatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Unresectable Cervical Carcinoma

description: A cervical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Stage IA Uterine Sarcoma AJCC v7

description: Stage IA includes: T1a, N0, M0.  T1a: For leiomyosarcoma and endometrial stromal sarcoma: tumor 5 cm or less in greatest dimension.  For adenosarcoma: tumor limited to endometrium/endocervix.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


tonsil neoplasm

description: A neoplasm (disease) that involves the tonsil.


benign neoplasm of tonsil

description: A benign neoplasm that involves the tonsil.


tonsillar lipoma

description: A benign adipose tissue neoplasm of the tonsils.


Volar Melanoma

description: A melanoma that arises from the palmar surface of hands and plantar surface of feet.


Eccrine angiomatous hamartoma

description: A rare, congenital skin lesion consisting of a proliferation of eccrine glands with a vascular stroma. It presents as a flesh-colored, hyperhidrotic, painful papule or plaque appearing at birth or during childhood.


hereditary painful callosities

description: Hereditary painful callosities is a nummular palmoplantar keratoderma characterized by the development of painful keratotic lesions over pressure points in hands and feet. A few families have been described. Transmission is autosomal dominant. Successful analgesia can be obtained with tretinoin.


name: Undifferentiated Juvenile Idiopathic Arthritis

description: A category of juvenile idiopathic arthritis that does not fulfill any single category or has criteria for more than one category.


name: Stage IVB Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy AJCC v8

description: Stage IVB includes: T0, N3, M0. T0: No evidence of primary tumor. N3: Metastasis in a cervical lymph node larger than 6 cm in greatest dimension and ENE(-); or metastases in a single ipsilateral cervical lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral cervical lymph nodes, any size and ENE(+) in any node. M0: No distant metastasis. (AJCC 8th Ed.)


name: Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy by AJCC v8 Stage

description: A term that refers to the staging of unknown primary tumor (except for EBV-related and HPV-related tumors) and metastatic cervical adenopathy according to the American Joint Committee on Cancer, 8th edition.


name: Stage IVA Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy AJCC v8

description: Stage IVA includes: T0, N2, M0. T0: No evidence of primary tumor. N2: Metastasis in a single ipsilateral or contralateral cervical lymph node 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral cervical lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral cervical lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral cervical lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th Ed.)


name: Stage IVC Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy AJCC v8

description: Stage IVC includes: T0, Any N, M1. T0: No evidence of primary tumor. M1: Distant metastasis. (AJCC 8th Ed.)


name: Stage III Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy AJCC v8

description: Stage III includes: T0, N1, M0. T0: No evidence of primary tumor. N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE (extranodal extension)(-). M0: No distant metastasis. (AJCC 8th Ed.)


name: Recurrent Metastatic Merkel Cell Carcinoma

description: The reemergence of a metastatic Merkel cell carcinoma after a period of remission.


Recurrent Metastatic Malignant Neoplasm

description: The reemergence of a metastatic malignant neoplasm after a period of remission.


Recurrent Metastatic Melanoma

description: The reemergence of metastatic melanoma after a period of remission.


Recurrent Carcinoma of Unknown Primary

description: The reemergence of carcinoma from an unknown primary after a period of remission.


name: Recurrent Metastatic Digestive System Carcinoma

description: The reemergence of a metastatic digestive system carcinoma after a period of remission.


Recurrent Pseudomyxoma Peritonei

description: The reemergence of pseudomyxoma peritonei after a period of remission.


name: Recurrent Metastatic Malignant Neoplasm in the Leptomeninges

description: The reemergence of a metastatic malignant neoplasm in the leptomeninges after a period of remission.


Recurrent Metastatic Gastric Carcinoma

description: The reemergence of metastatic gastric carcinoma after a period of remission.


name: Recurrent Metastatic Skin Squamous Cell Carcinoma

description: The reemergence of a metastatic skin squamous cell carcinoma after a period of remission.


name: Deafness due to Connexin 26 Gene Anomaly

description: Congenital deafness caused by mutations in the gene GJB2 (deafness gene).


Complete neonatal hearing loss

description: Complete loss of the ability to detect or understand sounds present in an infant within its first month after birth.


Neonatal hearing loss

description: Partial or complete loss of the ability to detect or understand sounds present in an infant within its first month after birth.


central hearing loss

description: Hearing loss resulting from disorders of the central nervous system auditory pathways.


Hearing Loss, Functional

description: Hearing loss in the absence of auditory system pathology.


name: Mitochondrially Inherited Nonsyndromic Sensorineural Deafness

description: A maternally inherited form of nonsyndromic sensorineural deafness that is caused by a mutation in any of several mitochondrial genes.


Deafness, Autosomal Recessive 12

description: A genetic condition inherited in an autosomal recessive caused by mutation(s) in the CDH23 gene, encoding cadherin-23, characterized by progressive sensorineural hearing loss. Mutation(s) in the CDH23 gene may also cause Usher syndrome 1D.


Partial neonatal hearing loss

description: Partial loss of the ability to detect or understand sounds present in an infant within its first month after birth.


Deafness, Autosomal Dominant 58

description: A genetic condition inherited in an autosomal dominant fashion linked to chromosome 2p21-p12, characterized by bilateral hearing loss.


hand dermatosis

description: Skin conditions characterized by dense infiltration of inflammatory cells (neutrophils) in the affected tissue. They arise in reaction to some underlying systemic illness. A neutrophilic dermatosis may be seen in isolation or more than one type may occur in the same individual.


arthus reaction

description: A localized vasculitis resulting from deposition of antibody-antigen complexes.


name: Testicular Mixed Choriocarcinoma and Teratoma

description: A malignant mixed germ cell tumor arising from the testis.  It is characterized by the presence of a teratomatous component and malignant syncytiotrophoblastic cells.


eyelid degenerative disorder

description: A neurodegenerative disease that involves the eyelid.


External Prosthetic Device Pain

description: Pain that is associated with an external artificial replacement device.


benign neoplasm of endometrium

description: A benign neoplasm that involves the endometrium.


severe pre-eclampsia

description: Preeclampsia with a systolic blood pressure of 160 mmHg or higher, or a diastolic blood pressure of 110 mmHg or higher on two occasions at least 4 hours apart while on bedrest. It is associated with thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.


name: Malignant nasopharyngeal neoplasm recurrent

description: The reemergence of a nasopharyngeal malignant neoplasm after a period of remission.


Lymphoma of kidney

description: A lymphoma that arises from the kidney. There is no evidence of a systemic lymphoproliferative disorder.


cholane derivative

Any steroid (or derivative) based on a cholane skeleton.


A steroid compound with a structure based on a 24-carbon (cholane) skeleton.


name: follicular dendritic cell sarcoma of mediastinum

description: A rare follicular dendritic cell sarcoma that affects the structures of the mediastinum.


name: Acute Myeloid Leukemia with SF3B1 Mutation

description: An acute myeloid leukemia associated with SF3B1 gene mutation.


streptococcus pneumoniae discitis

description: Discitis caused by infection with Streptococcus pneumoniae.


Ewing sarcoma of bone

description: A small round cell bone tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal tumor. It often affects the diaphysis or metaphyseal-diaphyseal portion of long bones. Clinical findings include pain and a mass in the involved area. fever, anemia, leukocytosis, and an increased sedimentation rate are often seen. X-ray examination reveals osteolytic lesions. The prognosis depends on the stage, anatomic location, and size of the tumor.


acute hypotension

description: Acute form of hypotension (disease).


name: Pancreatic Mucinous-Cystic Neoplasm, High Grade

description: A non-invasive mucinous cystic neoplasm that arises from the pancreas and is characterized by the presence of severe dysplasia.  The neoplastic columnar mucin-producing epithelial cells form papillae with irregular branching and budding.  There is nuclear stratification, prominent nucleoli, and cellular pleomorphism.  Mitotic activity is present and the mitoses may be atypical.


name: Parenteral Nutrition - Associated Cholestasis

description: Cholestasis that results from prolonged total parenteral nutrition. It is caused by diminished bile flow from the liver into the duodenum. It may result in cirrhosis and liver failure. Preterm infants are most susceptible to liver damage.


Recurrent Intrahepatic Cholestasis

description: Reappearance of cholestasis caused by obstruction within the liver.


Genital rhabdomyoma

description: A rare benign skeletal muscle neoplasm arising from the female genital tract. It is characterized by the presence of small nucleated rhabdomyoblasts within a fibrous and myxoid stroma.


Benign Skeletal Muscle Neoplasm

description: A benign mesenchymal neoplasm arising from skeletal muscle tissue.


Extracardiac Rhabdomyoma

description: A benign mesenchymal neoplasm that shows mature skeletal muscle differentiation.


Central Nervous System Rhabdomyoma

description: A benign mesenchymal neoplasm arising from the central nervous system.  It consists of mature skeletal muscle tissue.


Vulvar Rhabdomyoma

description: A rare benign polypoid skeletal muscle neoplasm arising from the vulva. It is characterized by the presence of round striated muscle cells and strap-like skeletal muscle cells, and vascular space formations within a fibrous and myxoid stroma.


Fetal rhabdomyoma

description: A rare benign mesenchymal neoplasm arising from skeletal muscle. It is characterized by the presence of immature spindle and polygonal cells within a scant myxoid stroma. It usually develops in the head and neck region of young children.


Paratesticular Rhabdomyoma

description: A rhabdomyoma that arises from the paratesticular region.


Vaginal Rhabdomyoma

description: A rare benign polypoid skeletal muscle neoplasm arising from the vagina.  It is characterized by the presence of round striated muscle cells and strap-like skeletal muscle cells, and vascular space formations within a fibrous and myxoid stroma.


Head and Neck Rhabdomyoma

description: A benign neoplasm with skeletal muscle differentiation that arises from the head and neck. It usually affects the mouth, parapharyngeal space, larynx, salivary glands, and soft tissue of the neck.


Intermediate Rhabdomyoma

description: A morphologic variant of fetal rhabdomyoma characterized by the presence of spindle cell myoblasts and strap-like skeletal muscle cells.


Adult Extracardiac Rhabdomyoma

description: A benign mesenchymal neoplasm arising from skeletal muscle and occurring in adults.


Classic Rhabdomyoma

description: A morphologic variant of fetal rhabdomyoma characterized by the presence of a prominent myxoid stroma and primitive skeletal spindle cells.


Mediastinal Rhabdomyoma

description: A rare benign skeletal muscle neoplasm arising from the mediastinum.


mesenteric lymphadenitis

description: Inflammation of the mesenteric lymph nodes.


trihydroxyflavanone

A hydroxyflavanone carrying three hydroxy substituents.


(R)-naringenin

The (R)-enantiomer of naringenin.


name: Stage IB Fallopian Tube Cancer AJCC v6 and v7

description: Stage IB includes: T1b, N0, M0.  T1b: Tumor limited to both tubes, without penetrating the serosal surface; no ascites.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Expanding aneurysm

description: Expansion of aneurysm.


name: follicular atrophoderma-basal cell carcinoma


Metastatic Malignant Abdominal Neoplasm

description: A malignant neoplasm that arises from the abdomen and has spread from its original site of growth to another anatomic site.


Advanced Malignant Abdominal Neoplasm

description: A malignant neoplasm that arises from the abdomen and has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Pleomorphic Liposarcoma

description: Pleomorphic liposarcoma that is resistant to treatment.


20q11.2 microduplication syndrome

description: 20q11.2 microduplication syndrome is a rare chromosomal anomaly syndrome, due to partial duplication of the long arm of chromosome 20, characterized by psychomotor and developmental delay, moderate intellectual disability, metopic ridging/trigonocephaly, short hands and/or feet and distinctive facial features (epicanthus, hypoplastic supraorbital ridges, horizontal/downslanting palpebral fissures, small nose with depressed nasal bridge and anteverted nostrils, prominent cheeks, retrognathia and small, thick ears). Growth delay and cryptororchidism are often associated features.


name: congenital narrowing of cervical spinal canal

description: Congenital cervical spinal stenosis is a rare neurological disease characterized by a congenital narrowing of the bony anatomy of the cervical spinal canal (sagittal diameter <14mm), predisposing the individual to symptomatic neural compression, such as cramps, paresthesias, pain, muscle hypertonia and weakness, myelopathy and sphincter disturbances.


Vas deferens perforation

description: A rupture in the wall of the vas deferens.


Retinoblastoma, diffuse

description: A retinoblastoma characterized by the absence of a distinct retinal mass and the presence of malignant cells diffusely infiltrating the retina. It is often confused with uveitis and endophthalmitis, resulting in delayed diagnosis of the malignancy.


name: mesoaxial hexadactyly and cardiac malformation


name: developmental delay with or without intellectual impairment or behavioral abnormalities


mesocestoidiasis

description: An disease or disorder caused by infection with Mesocestoides.


name: Refractory Vaginal Squamous Cell Carcinoma

description: Vaginal squamous cell carcinoma that is resistant to treatment.


name: 2:1 Atrioventricular Block by ECG Finding

description: An electrocardiographic finding of a supraventricular rhythm where the ratio of impulses generated above the atrioventricular node to the number of impulses conducted through to the ventricles is 2:1. This is manifested on the ECG as 2 P waves per QRS complex. (CDISC)


Factor V Inactivation

description: Presence of inactivating antibodies to factor V in the blood.


acquired factor V deficiency

description: An acquired coagulation disorder characterized by the partial or complete absence of factor V activity in the blood.


Gallbladder Adenoma, Intestinal-Type

description: An adenoma that arises from the gallbladder and is associated with intestinal-type differentiation.


neoplastic polyp

description: A term that includes all polypoid growth from the inner lining of the mucous membrane.


Cervical Microglandular Polyp

description: A benign endocervical polypoid epithelial hyperplasia characterized by the presence of tightly packed glandular structures. It is usually seen in women on oral contraceptive therapy and during pregnancy.


tubular adenoma of stomach

description: An intestinal-type adenoma that arises from the stomach. It is characterized by the presence of a tubular architectural pattern.


Precancerous Polyp

description: A polyp with severe dysplastic features.


polyposis

description: A condition characterized by the presence of numerous polyps.


villous adenoma of stomach

description: An intestinal-type adenoma that arises from the stomach. It is characterized by the presence of a villous architectural pattern.


adenomatous polyp of stomach

description: A neoplastic polyp that arises from the stomach. It is associated with intestinal-type differentiation. The presence of high grade dysplasia and a size of more than 2 cm are factors that increase the risk of malignant transformation.


Ampulla of Vater Tubular Adenoma

description: An intestinal-type adenoma arising from the ampulla of Vater.  It is characterized by the presence of tubular epithelial structures and it is associated with dysplasia.


Eosinophilic granulomatous polyp

description: A benign, often polypoid, hypocellular fibroblastic neoplasm with a predilection for the stomach and ileum, containing a prominent inflammatory infiltrate, especially eosinophils. (WHO 2019)


Ampulla of Vater Villous Adenoma

description: An intestinal-type adenoma arising from the ampulla of Vater.  It is characterized by the presence of villous epithelial structures and it is associated with dysplasia.


Endocervical polyp

description: A polyp that arises from the endocervix. It is characterized by the presence of endocervical glands and a fibrovascular stroma.


Fallopian Tube Endometrioid Polyp

description: An adenomatous polyp that arises from the interstitial portion of the fallopian tube and is characterized by the presence of endometrial epithelium.  It may obstruct the lumen of the fallopian tube and result in infertility or tubal pregnancy.


Colorectal Adenomatous Polyp

description: A polypoid adenoma that arises from and protrudes into the lumen of the colon or rectum.  Epithelial dysplasia is always present.  According to the architectural pattern it is classified as tubular, tubulovillous, or villous.


Adenoma of ampulla of Vater

description: An adenoma that arises from the ampulla of Vater and resembles the adenomas of the small and large intestines.  Morphologically, according to the growth pattern, it may be classified as tubular, tubulovillous, or villous.  Dysplasia is always present.  Jaundice may be an early symptom.


Adenomatous polyp of rectum

description: A polypoid adenoma that arises from and protrudes into the lumen of the rectum.  Epithelial dysplasia is always present.  According to the architectural pattern it is classified as tubular, tubulovillous, or villous.


Intestinal-type adenoma

description: An adenoma that arises from the glandular epithelium of the gastrointestinal tract and is associated with intestinal-type differentiation.


tubulovillous adenoma of stomach

description: An intestinal-type adenoma that arises from the stomach. It is characterized by the presence of a tubulovillous architectural pattern.


tubulopapillary adenoma of gallbladder

description: A grossly visible non-invasive neoplasm of the gallbladder composed of uniform back-to-back mucinous glands arranged in a tubular configuration. (WHO 2019)


myxoid/round cell liposarcoma

description: Myxoid/round cell liposarcoma (MRCLS) is a type of liposarcoma (LS) mostly located in the limbs, with a variable behavior depending on the histological subtype. Both myxoid and round cell are distinct histological subtypes of LS.


ovarian myxoid liposarcoma

description: A liposarcoma that arises from the ovary and is composed of round to oval mesenchymal cells, small signet ring lipoblasts, and a rich network of capillaries in a myxoid stroma.


round cell liposarcoma

description: A poorly differentiated liposarcoma, characterized by the presence of solid sheets of primitive round mesenchymal cells and the absence of myxoid stroma.


Vaginal Cancer by AJCC v8 Stage

description: A term that refers to the staging of vaginal cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to all carcinomas of the vagina. There is no AJCC staging system for mucosal melanoma of the vagina. (from AJCC 8th Ed.)


Stage III Vaginal Cancer AJCC v8

description: Stage III includes: (T1-T3, N1, M0); (T3, N0, M0). T1: Tumor confined to the vagina. T2: Tumor invading paravaginal tissues but not to pelvic sidewall. T3: Tumor extending to the pelvic sidewall and/or involving the lower third of the vagina and/or causing hydronephrosis or nonfunctioning kidney. N0: No regional lymph node metastasis. N1: Pelvic or inguinal lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IV Vaginal Cancer AJCC v8

description: Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Tumor invading the mucosa of the bladder or rectum and/or extending beyond the true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4). M0: No distant metastasis. M1: Distant metastasis. (from AJCC 8th Ed.)


Stage II Vaginal Cancer AJCC v8

description: Stage II includes: IIA: T2a, N0, M0; IIB: T2b, N0, M0. T2a: Tumor invading paravaginal tissues but not to pelvic wall, measuring 2.0 cm or less. T2b: Tumor invading paravaginal tissues but not to pelvic wall, measuring more than 2.0 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Vaginal Cancer AJCC v8

description: Stage IIA includes: T2a, N0, M0. T2a: Tumor invading paravaginal tissues but not to pelvic wall, measuring 2.0 cm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIB Vaginal Cancer AJCC v8

description: Stage IIB includes: T2b, N0, M0. T2b: Tumor invading paravaginal tissues but not to pelvic wall, measuring more than 2.0 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IVB Vaginal Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


name: Unresectable Papillary Renal Cell Carcinoma

description: A papillary renal cell carcinoma that is not amenable to surgical resection.


Refractory Fibrolamellar Carcinoma

description: Fibrolamellar carcinoma that is resistant to treatment.


name: Prostate Stromal Proliferation of Uncertain Malignant Potential

description: A neoplastic lesion that arises from the prostate gland stroma.  Morphologic characteristics include hypercellular stroma with scattered atypical cells, prominent overgrowth of the prostatic stroma, or changes resembling benign phyllodes tumor.  The majority of cases do not have an aggressive clinical course.  A minority of cases however, may progress to stromal sarcoma.


cyanide

A pseudohalide anion that is the conjugate base of hydrogen cyanide.


Meyerson nevus

description: A benign melanocytic nevus surrounded by eczematous changes.


name: Metastatic malignant neoplasm to supraclavicular lymph nodes

description: The spread of a malignant neoplasm from its original site of growth to supraclavicular lymph nodes.


name: metastatic malignant neoplasm in the lymph nodes

description: The spread of a malignant neoplasm to the lymph nodes.


name: Metastatic Malignant Neoplasm in the Regional Lymph Nodes

description: The spread of a malignant neoplasm from its original site of growth to nearby lymph nodes.


name: Breast Carcinoma Metastatic in the Lymph Nodes

description: A carcinoma that arises from the breast and has spread to the lymph nodes.


Metastatic Melanoma in the Lymph Nodes

description: A melanoma that has spread to the lymph nodes from a cutaneous or extracutaneous primary site.


name: Metastatic malignant neoplasm to mediastinal lymph nodes

description: The spread of a malignant neoplasm to the mediastinal lymph nodes from an adjacent or distant anatomic site.


name: Prostate Carcinoma Metastatic in the Lymph Nodes

description: A carcinoma that arises from the prostate gland and has spread to the lymph nodes.


name: Metastatic Squamous Cell Carcinoma in the Cervical Lymph Nodes

description: A squamous cell carcinoma that has spread from its original site of growth to the cervical lymph nodes.


name: Dextro-Transposition of the Great Vessels with Intact Ventricular Septum

description: A congenital heart defect in which there is an abnormal arrangement of any of the primary blood vessels of the heart in conjunction with the notable absence of any pathologic opening between the cardiac ventricles.


name: microcephaly, severe, with skeletal anomalies including posterior rib-Gap defects


name: Central Nervous System Teratoma with Malignant Transformation

description: A central nervous system teratoma characterized by the presence of a malignant component. The malignant component most often is sarcomatous (rhabdomyosarcoma or undifferentiated sarcoma) or carcinomatous (squamous cell carcinoma or adenocarcinoma).


name: Sellar Teratoma with Malignant Transformation

description: A teratoma with malignant transformation that arises from or adjacent to the sellar region.


Stage IA1 Cervical Cancer

description: Stage IA1 includes: T1a1, N0, M0.  T1a1: Measured stromal invasion 3.0 mm or less in depth and 7.0 mm or less in horizontal spread.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IA Cervical Cancer AJCC v6 and v7

description: Stage IA includes: IA (T1a, N0, M0); IA1 (T1a1, N0, M0); IA2 (T1a2, N0, M0).  T1a: Invasive carcinoma diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. T1a1: Measured stromal invasion 3.0 mm or less in depth and 7.0 or less horizontal spread.  T1a2: Measured stromal invasion more than 3.0 mm and not more than 5.0 mm with a horizontal spread 7.0 mm or less.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IA2 Cervical Cancer

description: Stage IA2 includes: T1a2, N0, M0.  T1a2: Measured stromal invasion more than 3.0 mm and not more than 5.0 mm with a horizontal spread 7.0 mm or less.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: intellectual developmental disorder, autosomal recessive 82


Machado-Joseph disease type 2

description: Machado-Joseph disease type 2 is a subtype of Machado-Joseph disease (SCA3/MJD) with intermediate severity characterized by an intermediate age of onset, cerebellar ataxia and external progressive ophthalmoplegia, with variable pyramidal and extrapyramidal signs.


Machado-Joseph disease type 4

description: A subtype of Machado-Joseph disease characterized by Parkinsonian symptoms that respond particularly well to levodopa treatment.


Machado-Joseph disease type 3

description: Machado-Joseph disease type 3 is a subtype of Machado-Joseph disease (SCA3/MJD) of milder severity characterized by late onset, slower progression, and peripheral amyotrophy.


Machado-Joseph disease type 5

description: A subtype of Machado-Joseph disease characterized by resemblance to Hereditary Spastic Paraplegia; however, more research is needed to conclude the relationship between Type V MJD and hereditary spastic paraplegia.


Machado-Joseph disease type 1

description: Machado-Joseph disease type 1 is a rare, usually severe subtype of Machado-Joseph disease (SCA3/MJD) characterized by the presence of marked pyramidal and extrapyramidal signs.


name: metaphyseal modeling abnormality, skin lesions, and spastic paraplegia


name: Steroid Resistant Gastrointestinal Tract Acute Graft Versus Host Disease

description: Acute graft versus host disease occurring in the gastrointestinal tract that is resistant to treatment with steroids.


parotid disorder

description: A disease involving the parotid gland.


parotid gland neoplasm

description: A neoplasm (disease) that involves the parotid gland.


benign neoplasm of parotid gland

description: A benign neoplasm that involves the parotid gland.


Shock From Lead

description: Unintended electric shock from patient leads.


ectopic Cushing syndrome

description: Cushing syndrome due to ectopic (adrenocorticotropic hormone) ACTH secretion (EAS) is a form of ACTH-dependent Cushing syndrome caused by excess secretion of ACTH by a benign or, more often, malignant non-pituitary tumor.


name: ACTH-independent adrenal Cushing syndrome, somatic


name: Cushing syndrome due to cortisol-producing adrenocortical adenoma


ACTH-independent Cushing syndrome

description: Adrenocorticotropic hormone (ACTH) independent Cushing syndrome is a form of endogenous Cushing syndrome (CS) that may result from excess secretion of cortisol by either a unilateral and benign (adrenocortical adenoma: 55-60%) or malignant (adrenocortical carcinoma: 35-40 %) adrenocortical tumor or by bilateral adrenal secretion by macronodular adrenal hyperplasia (AIMAH), as an isolated disease or as part of McCune-Albright syndrome (MAS), or by primary pigmented nodular adrenocortical disease (PPNAD), as an isolated disease or as part of Carney complex (CNC).


name: microphthalmia, isolated, with coloboma 4


Hemoglobin SE disease

description: A variant of sickle cell disease due to heterozygosity for hemoglobin S and hemoglobin E mutations. Patients present with the symptoms of sickle cell disease but the symptoms are less frequent and severe compared to patients with hemoglobin SS disease.


name: Stage IV Colorectal Neuroendocrine Tumor AJCC v8

description: Stage IV includes: (T1, Any N, M1); (T2, Any N, M1); (T3, Any N, M1); (T4, Any N, M1). T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. T2: Tumor invading the muscularis propria or measuring more than 2 cm with invasion of the lamina propria or submucosa. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading the visceral peritoneum (serosa) or other organs or adjacent structures. M1: Distant metastasis. (AJCC 8th ed.)


name: Stage IV Colon Neuroendocrine Tumor AJCC v8


name: Stage IV Rectal Neuroendocrine Tumor AJCC v8


Pyogenic granuloma of oral mucosa

description: A lobular hemangioma arising from the oral mucosa.


Airway Infantile Hemangioma

description: A rare infantile hemangioma in the airway, usually in the subglottic area or trachea. It may or may not be associated with cutaneous lesions. It is a potentially life-threatening condition and the infant should be closely monitored for signs of airway disease.


Senile hemangioma of lip

description: A capillary hemangioma arising from the lip and presenting as a papular lesion.


name: Pyogenic granuloma of skin and subcutaneous tissue

description: A lobular hemangioma arising from the skin and attached subcutaneous tissues.


Anastomosing hemangioma

description: An unusual variant of capillary hemangioma. It is characterized by a unique anastomosing sinusoidal-like architecture which may mimic angiosarcoma. It was originally described in the kidney but rare cases have been reported in other sites.


Infantile hemangioma of liver

description: A capillary hemangioma that arises from the liver. It occurs in infants and children.


Infantile hemangioma

description: A capillary hemangioma that may regress spontaneously.  It occurs in infants and children.


Multiple Lobular Capillary Hemangiomas

description: A lobular hemangioma present in multiple anatomic sites.


Capillary hemangioma of orbit

description: A capillary hemangioma arising from the orbit.


Cardiac Capillary Hemangioma

description: A capillary hemangioma arising from the heart.


metastatic neoplasm

description: A tumor that has spread from its original (primary) site of growth to another site, close to or distant from the primary site. Metastasis is characteristic of advanced malignancies, but in rare instances can be seen in neoplasms lacking malignant morphology.


secondary neoplasm

description: A neoplasm that arises from a pre-existing lower grade lesion, or as a result of a primary lesion that has spread to secondary sites, or due to a complication of a cancer treatment.


name: metastatic malignant neoplasm in the colon

description: The spread of a malignant neoplasm to the colon. This may be from a primary large intestine malignant neoplasm, or from a malignant neoplasm at a distant site.


neoplastic meningitis

description: Metastatic neoplasm in which the tumor cells spread to leptomeninges (pia and arachnoid) and subarachnoid space. The most common primary tumors metastasizing to the leptomeninges are breast and lung carcinomas, melanoma, aggressive non-Hodgkin lymphoma, and acute lymphocytic leukemia.


name: metastatic malignant neoplasm in the eye

description: A malignant neoplasm that has spread to the eye from another anatomic site.


metastatic malignant neoplasm

description: A malignant tumor that has spread from its original (primary) site of growth to another site close to or distant from the primary site.


secondary malignant neoplasm

description: A malignant neoplasm that arises from a pre-existing lower grade lesion, or as a result of a primary lesion that has spread to secondary sites, or due to a complication of a cancer treatment.


Postoperative shock

description: A state of shock following a surgical operation.


name: Stage II Appendix Neuroendocrine Tumor AJCC v7

description: Stage II includes: T2, T3, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm or with extension to the cecum. T3: Tumor more than 4 cm or with extension to the ileum.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Adult Ependymoma

description: An ependymoma occurring in adults.


name: Adult Supratentorial Ependymoma ZFTA Fusion-Positive

description: A supratentorial ependymoma ZFTA fusion-positive that occurs in adults.


Adult Posterior Fossa Ependymoma

description: A posterior fossa ependymoma that occurs in adults.


Advanced Genitourinary System Carcinoma

description: A genitourinary system carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Bladder Urothelial Carcinoma

description: Bladder urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Urethral Urothelial Carcinoma

description: A urethral urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Vaginal Adenosquamous Carcinoma

description: Vaginal adenosquamous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Endometrial Carcinoma

description: An endometrial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that has spread extensively from its original site of growth to other anatomic sites or is no longer responding to treatment.


Advanced Ureter Urothelial Carcinoma

description: Ureter urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Penile Carcinoma

description: Penile carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Vaginal Squamous Cell Carcinoma

description: Vaginal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Cervical Carcinoma

description: A cervical carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Platinum-Refractory Ovarian Carcinoma

description: Platinum-refractory ovarian carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Bladder Carcinoma

description: A bladder carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Platinum-Resistant Ovarian Carcinoma

description: Platinum-resistant ovarian carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Ovarian Carcinoma

description: An ovarian carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Urothelial Carcinoma

description: Urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Renal Pelvis and Ureter Urothelial Carcinoma

description: Renal pelvis and ureter urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Microsatellite Stable Ovarian Carcinoma

description: Microsatellite stable ovarian carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Microsatellite Stable Endometrial Carcinoma

description: Microsatellite stable endometrial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Vaginal Carcinoma

description: Vaginal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Endometrial Undifferentiated Carcinoma

description: Endometrial undifferentiated carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Vulvar Carcinoma

description: Vulvar carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Prostate Carcinoma

description: A prostatic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Vaginal Squamous Cell Carcinoma, Not Otherwise Specified

description: Vaginal squamous cell carcinoma, not otherwise specified that that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Cervical Adenosquamous Carcinoma

description: Cervical adenosquamous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Recurrent Lymphomatoid Granulomatosis

description: The reemergence of lymphomatoid granulomatosis after a period of remission.


name: Recurrent Grade II Lymphomatoid Granulomatosis

description: The reemergence of grade II lymphomatoid granulomatosis after a period of remission.


name: Recurrent Grade I Lymphomatoid Granulomatosis

description: The reemergence of grade I lymphomatoid granulomatosis after a period of remission.


name: Recurrent Childhood Lymphomatoid Granulomatosis

description: The reemergence of lymphomatoid granulomatosis in childhood after a period of remission.


RP2-related retinopathy

description: A retinopathy caused by variants in the X-linked gene, RP2.


carbotetracyclic compound

A carbopolyclic compound comprising of four carbocyclic rings.


name: Extraocular Cutaneous Sebaceous Carcinoma

description: A rare variant of sebaceous carcinoma that does not affect the ocular region.


Conjunctival Sebaceous Carcinoma

description: A rare sebaceous carcinoma that arises from the conjunctiva.


Metastatic Sebaceous Carcinoma

description: Sebaceous carcinoma that has spread from the original site of growth to other anatomic sites.


Recurrent Sebaceous Carcinoma

description: The reemergence of sebaceous carcinoma after a period of remission.


sebaceous carcinoma of salivary gland

description: A rare sebaceous carcinoma that arises from the salivary glands.


Refractory Sebaceous Carcinoma

description: Sebaceous carcinoma that is resistant to treatment.


Head and Neck Sebaceous Carcinoma

description: A sebaceous carcinoma that arises from the head and neck region.


infection by Trypanosoma gambiense

description: Trypanosomiasis caused by infection by Trypanosoma brucei gambiense.


early yaws

description: Early yaws includes primary and secondary stages of yaws, endemic tropical treponemal nonvenereal infection: development of initial lesion at inoculation site followed by widespread dissemination of treponemes and generalized secondary granulomatous lesions that may relapse repeatedly.


infection by Trypanosoma rhodesiense

description: An infection with Trypanosoma brucei rhodesiense.


late yaws

description: Late yaws is the tertiary, non-contagious stage of yaws, endemic tropical treponemal nonvenereal infection. Late yaws is characterized by destructive and deforming lesions of the skin, bones, and joints.


yaws

description: An endemic, infectious, nonvenereal disease in humans that presents mainly in children younger than 15 years. The disease occurs primarily in warm, humid, tropical areas of Africa, Asia, South America, and Oceania, among poor rural populations where conditions of overcrowding and poor sanitation prevail. Infection with Treponema pertenue, a subspecies of Treponema pallidum, causes the disease.


name: chronic lymphoproliferative disorder of NK-cells

description: An Epstein-Barr virus negative disorder with a chronic clinical course affecting predominantly adults and characterized by the proliferation of large granular lymphocytes with natural killer cell immunophenotype. The T-cell receptor genes are not rearranged.


name: parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development


hymenolepiasis

description: A parasitic infection caused by tapeworms. Most infected individuals do not have symptoms. When symptoms appear, they include diarrhea, abdominal pain, restlessness, and irritability.


congenital aortic valve insufficiency

description: Dysfunction of the aortic valve characterized by incomplete valve closure that is present at birth.


Heart valve regurgitation

description: Dysfunction of one of the cardiac valves characterized by incomplete valve closure.


mitral valve disorder

description: A disease involving the mitral valve.


Rheumatic tricuspid valve regurgitation

description: Tricuspid valve insufficiency secondary to rheumatic fever.


name: Congenital insufficiency of pulmonary valve

description: Dysfunction of the pulmonary valve characterized by incomplete valve closure that is present at birth.


lateral sinus thrombosis

description: Formation or presence of a blood clot (thrombus) in the lateral sinuses. This condition is often associated with ear infections (otitis media or mastoiditis) without antibiotic treatment. In developed nations, lateral sinus thrombosis can result from craniocerebral trauma; brain neoplasms; neurosurgical procedures; thrombophilia; and other conditions. Clinical features include headache; vertigo; and increased intracranial pressure.


cavernous sinus thrombosis

description: Formation or presence of a blood clot (thrombus) in the cavernous sinus of the brain. Infections of the paranasal sinuses and adjacent structures, craniocerebral trauma, and thrombophilia are associated conditions. Clinical manifestations include dysfunction of cranial nerves iii, iv, V, and vi, marked periorbital swelling, chemosis, fever, and visual loss. (From Adams et al., Principles of Neurology, 6th ed, p711)


Arteriovenous fistula stenosis

description: Narrowing of the lumen of an arteriovenous fistula.


name: Triple-Class Refractory Multiple Myeloma

description: Multiple myeloma that is resistant to three classes of therapeutic agents, including proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies.


apocrine sweat gland disorder

description: A disease that involves the apocrine sweat gland.


hidradenitis

description: An inflammatory disease involving a pathogenic inflammatory response in the apocrine sweat gland.


familial acne inversa

description: An instance of hidradenitis suppurativa that is caused by an inherited modification of the individual's genome.


apocrine adenoma

description: A benign epithelial neoplasm arising from the apocrine sweat glands. Representative examples include tubular apocrine adenoma and external auditory canal ceruminous adenoma.


apocrine sweat gland cancer

description: A malignant neoplasm involving the apocrine sweat gland.


apocrine sweat gland neoplasm

description: A benign or malignant sweat gland neoplasm with apocrine differentiation. Representative examples include apocrine adenoma, ceruminous adenocarcinoma, and apocrine breast carcinoma.


Dextrocardia Situs Solitus

description: A congenital heart defect in which the heart is located in the right side and the other organs are in their normal position.


Recurrent Childhood Pineoblastoma

description: The reemergence of pineoblastoma in childhood after a period of remission.


Trichomonas prostatitis

description: Infection of the prostate gland caused by Trichomonas vaginalis.


name: Renal Tubular Acidosis Associated With Deafness

description: Renal tubular acidosis associated with sensorineural hearing loss, and which is typically associated with recessive mutations.


Fetal acidosis

description: An abnormally high hydrogen ion concentration (umbilical arterial blood pH less than 7.00) in fetal blood or tissue.


name: Refractory Chronic Myelomonocytic Leukemia

description: Chronic myelomonocytic leukemia that is resistant to treatment.


mediastinum rhabdomyosarcoma

description: A malignant mesenchymal tumor with skeletal muscle differentiation affecting the mediastinum.


ethmoidal sinus neoplasm

description: A benign or malignant neoplasm that affects the ethmoid sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma.


benign neoplasm of sphenoidal sinus

description: A non-metastasizing neoplasm that arises from the sphenoid sinus.


sphenoidal sinus neoplasm

description: A benign or malignant neoplasm that affects the sphenoid sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma.


maxillary sinus neoplasm

description: A benign or malignant neoplasm that affects the maxillary sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma.


benign neoplasm of ethmoidal sinus

description: A benign neoplasm that involves the ethmoid sinus.


benign neoplasm of maxillary sinus

description: A benign neoplasm that involves the maxillary sinus.


paranasal sinus cancer

description: A primary or metastatic malignant neoplasm involving the paranasal sinuses.


ethmoid sinus ectopic meningioma

description: An extremely rare meningioma that arises as a primary ectopic tumor in the ethmoid sinus.


frontal sinus neoplasm

description: A benign or malignant neoplasm that affects the frontal sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma.


benign neoplasm of frontal sinus

description: A benign neoplasm that involves the frontal sinus.


paranasal sinus lymphoma

description: A lymphoma that arises from the paranasal sinus. Representative examples include diffuse large B-cell lymphoma and extranodal NK/T-cell lymphoma, nasal type.


Carcinoid tumor of the duodenum

description: A well differentiated, low grade neuroendocrine neoplasm that arises from the duodenum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


adult germ cell tumor

description: A germ cell tumor that occurs during adulthood.


adult teratoma

description: A teratoma that occurs in an adult.


adult cystic teratoma

description: A cystic teratoma that occurs in an adult.


Paranasal Sinus Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the paranasal sinuses.


Preterm Birth Complication

description: A complication related to a premature birth that occurs to a baby born prior to 37 weeks gestation.


Gollop-Wolfgang complex

description: Gollop-Wolfgang complex is a very rare malformation characterized by ectrodactyly of the hand and ipsilateral bifurcation of the femur.


Metastatic Salivary Duct Carcinoma

description: Salivary duct carcinoma that has spread from its original site of growth to another anatomic site.


Recurrent Salivary Duct Carcinoma

description: The reemergence of salivary duct carcinoma after a period of remission.


name: Stage I Rectal Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


CIC-DUX4 Sarcoma

description: An undifferentiated, high grade small round cell sarcoma affecting predominantly young adults. It is characterized by a recurrent translocation involving the CIC gene on chromosome 19 and DUX4 gene on chromosome 4. The translocation results in CIC-DUX4, t(4;19)(q35;q13) fusions.


Senile dementia

description: Loss of intellectual abilities in an elderly person, interfering with this person's activities.


aminodiol

An amino alcohol having two hydroxy functional groups.


A 2-aminooctadecene-1,3-diol having its double bond at position 4.


An aminodiol composed of any octadecene having hydroxy functional groups at positions 1 and 3 and an amino substituent at position 2.


sphingenine

A 2-aminooctadecene-1,3-diol having (2S,3R)-configuration.


A sphingenine in which the C=C double bond is located at the 4-position.


An aminodiol that is octadecane bearing two hydroxy substituents at positions 1 and 3 as well as an amino substituent at position 2.


name: chronic lymphocytic leukemia/small lymphocytic lymphoma

description: An indolent, mature B-cell neoplasm composed of small, round B-lymphocytes. When the bone marrow and peripheral blood are involved, the term chronic lymphocytic leukemia is used. The term small lymphocytic lymphoma is restricted to cases which do not show leukemic involvement of the bone marrow and peripheral blood.


name: intrapelvic lymph node leukemic reticuloendotheliosis


refractory hairy cell leukemia

description: Hairy cell leukemia that is resistant to treatment.


name: pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma

description: A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) that lacks somatic hypermutations of the Immunoglobulin heavy chain (IGH) genes, implying pregerminal center B-cell origin. Microarray gene expression profiling studies have demonstrated the expression of ZAP-70 gene (Syk family tyrosine kinase) in this subset of CLL/CLL. Patients with this variant of CLL/SLL have an unfavorable prognosis compared to those with somatic hypermutations of the IGH genes, with a median survival of approximately 6-8 years.


name: chronic lymphocytic leukemia/small lymphocytic lymphoma with immunoglobulin heavy chain variable-region gene somatic hypermutation

description: A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) expressing somatic hypermutations of the Immunoglobulin heavy chain (IGH) genes. The recognition of this variant alters the belief that CLL/SLL is always derived from a naive, pregerminal center B-cell. The presence of somatic hypermutations of IGH genes occurs in approximately 50% of CLL/SLL cases and implies a postgerminal center, memory origin. Patients with this variant of CLL/SLL have a favorable prognosis, with a reported median survival of more than 24 years.


pars planitis

description: An inflammatory disorder of the cilliary body in the uvea that affects healthy, younger individuals who are often asymptomatic. It has a long clinical course with relapses and remissions. Symptoms include mildly decreased vision and floaters. It may be associated with autoimmune disorders.


name: Breast Classic Lobular Carcinoma In Situ Type B

description: Breast classic lobular carcinoma in situ  characterized by the presence of neoplastic cells with nuclei of various sizes and shapes.


name: Early Stage HER2-Negative Breast Carcinoma

description: A HER2-negative breast adenocarcinoma that has not spread beyond the breast and the axillary lymph nodes.


name: Prognostic Stage IIIA Breast Cancer AJCC v8

description: Stage IIIA includes: (T0-1, N1, M0, G2, HER2 Status: Negative, ER Status: Negative, PR Status: Negative); (T0-1, N1, M0, G3, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T0-1, N1, M0, G3, HER2 Status: Negative, ER Status: Negative, PR Status: Any); (T2, N0, M0, G2, HER2 Status: Negative, ER Status: Negative, PR Status: Negative); (T2, N0, M0, G3, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T2, N0, M0, G3, HER2 Status: Negative, ER Status: Negative, PR Status: Any); (T2, N1, M0, G1, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T2, N1, M0, G2, HER2 Status: Positive, ER Status: Negative, PR Status: Negative); (T2, N1, M0, G2, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T2, N1, M0, G3, HER2 Status: Positive, ER Status: Positive, PR Status: Negative); (T2, N1, M0, G3, HER2 Status: Positive, ER Status: Negative, PR Status: Negative); (T3, N0, M0, G1, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T3, N0, M0, G2, HER2 Status: Positive, ER Status: Negative, PR Status: Negative); (T3, N0, M0, G2, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T3, N0, M0, G3, HER2 Status: Positive, ER Status: Positive, PR Status: Negative); (T3, N0, M0, G3, HER2 Status: Positive, ER Status: Negative, PR Status: Negative); (T0-2, N2, M0, G1, HER2 Status: Positive, ER Status: Positive, PR Status: Negative); (T0-2, N2, M0, G1, HER2 Status: Positive, ER Status: Negative, PR Status: Any); (T0-2, N2, M0, G1, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T0-2, N2, M0, G1, HER2 Status: Negative, ER Status: Negative, PR Status: Positive); (T0-2, N2, M0, G2, HER2 Status: Positive, ER Status: Positive, PR Status: Negative); ( T0-2, N2, M0, G2, HER2 Status: Positive, ER Status: Negative, PR Status: Any); (T3, N1-2, M0, G1, HER2 Status: Positive, ER Status: Positive, PR Status: Negative); (T3, N1-2, M0, G1, HER2 Status: Positive, ER Status: Negative, PR Status: Any); (T3, N1-2, M0, G1, HER2 Status: Negative, ER Status: Positive, PR Status: Negative); (T3, N1-2, M0, G1, HER2 Status: Negative, ER Status: Negative, PR Status: Positive); (T3, N1-2, M0, G2, HER2 Status: Positive, ER Status: Positive, PR Status: Negative); (T3, N1-2, M0, G2, HER2 Status: Positive, ER Status: Negative, PR Status: Any); (T4, N0-2, M0, G1, HER2 Status: Negative, ER Status: Positive, PR Status: Positive); (Any T, N3, M0, G1, HER2 Status: Negative, ER Status: Positive, PR Status: Positive). T0: No evidence of primary tumor. T1: Tumor measuring 20 mm or less in greatest dimension. T2: Tumor measuring more than 20 mm, but not more than 50 mm in greatest dimension. T3: Tumor measuring more than 50 mm in greatest dimension. T4: Tumor of any size with direct extension to the chest wall and/or to the skin (ulceration or macroscopic nodules); invasion of the dermis alone does not qualify as T4. N0: No regional lymph node metastasis is identified or isolated tumor cell clusters (ITCs) are identified only. N1: Tumor with micrometastases; or metastases in 1-3 axillary lymph nodes; and/or clinically negative internal mammary nodes with micrometastases or macrometastases by sentinel lymph node biopsy. N2: Tumor with metastases in 4-9 axillary lymph nodes; or positive ipsilateral internal mammary lymph nodes by imaging in the absence of axillary lymph node metastases. N3: Tumor with metastases in 10 or more axillary lymph nodes; or in infraclavicular (level III axillary) lymph nodes; or positive ipsilateral internal mammary lymph nodes by imaging in the presence of one or more positive level I, II axillary lymph nodes; or in more than three axillary lymph nodes and micrometastases or macrometastases by sentinel lymph node biopsy in clinically negative ipsilateral internal mammary lymph nodes; or in ipsilateral supraclavicular lymph nodes. G1: Low combined histologic grade (favorable); SBR score of 3-5 points. G2: Intermediate combined histologic grade (moderately favorable); SBR score: 6-7 points. G3: High combined histologic grade (unfavorable); SBR score of 8-9 points. M0: No clinical or radiographic evidence of distant metastases. Imaging studies are not required to assign the M0 category. (AJCC 8th ed.)


name: Breast Ductal Carcinoma In Situ and Invasive Lobular Carcinoma

description: A breast carcinoma characterized by the presence of a ductal carcinoma in situ component and an invasive lobular carcinomatous component.


Localized Breast Carcinoma

description: Breast carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites.


Invasive Breast Cribriform Carcinoma

description: An invasive adenocarcinoma of the breast with a favorable clinical outcome, characterized by the presence of a sieve-like or cribriform infiltrating pattern.


name: Intraductal Micropapillary Breast Carcinoma

description: Breast ductal carcinoma in situ characterized by the presence of neoplastic epithelial cells arranged in micropapillary patterns.


name: Solid papillary carcinoma in situ of breast

description: Breast solid papillary carcinoma characterized by the presence of nodules with rounded, well-circumscribed contours and a distribution pattern consistent with an in situ process. (WHO 2019)


Stage IIA Breast Carcinoma

description: Stage IIA includes: (T0, N1, M0); (T1, N1, M0); (T2, N0, M0).  T0: No evidence of primary tumor.  T1: Tumor 20 mm or less in greatest dimension.  T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. T2: Tumor more than 20 mm but not more than 50 mm in greatest dimension.  N1: Metastasis to movable ipsilateral level I, II axillary lymph node(s).  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  M0 includes M0(i+).  (AJCC 6th and 7th Eds.)


Stage IIIC Breast Cancer AJCC v7

description: Stage IIIC includes: Any T, N3, M0.  N3: Metastases in ipsilateral infraclavicular (level III) axillary lymph nodes(s) with or without level I, II axillary lymph node involvement; or in clinically detected ipsilateral internal mammary lymph node(s) with clinically evident level I, II axillary lymph node metastases; or metastases in ipsilateral supraclavicular lymph node(s) with or without axillary or internal mammary lymph node involvement.  M0: No clinical or radiographic evidence of distant metastasis.  M0 includes M0(i+).  (AJCC 7th Ed.)


name: Recurrent Hormone Receptor-Negative Breast Carcinoma

description: The reemergence of hormone receptor-negative breast carcinoma after a period of remission.


breast angiosarcoma

description: A malignant vascular neoplasm arising from the breast.


name: Invasive Breast Lobular Carcinoma, Solid Variant

description: A grade I invasive lobular carcinoma of the breast, characterized by the presence of neoplastic cells that form trabeculae and groups infiltrating collagen bundles.


name: Metastatic Triple-Negative Breast Carcinoma

description: A triple-negative breast carcinoma that has spread from its original site of growth to another anatomic site.


name: Invasive Breast Lobular Carcinoma with Predominant In Situ Component

description: A breast carcinoma characterized by the presence of a predominant lobular carcinoma in situ component and a minor component of invasive carcinoma.


Recurrent Malignant Breast Neoplasm

description: The reemergence of a malignant breast neoplasm after a period of remission.


name: Invasive Breast Lobular Carcinoma, Alveolar Variant

description: A grade I invasive lobular carcinoma of the breast, characterized by the presence of round groups of neoplastic cells.


Hereditary Female Breast Carcinoma

description: Breast carcinoma that has developed in female relatives of patients with history of breast carcinoma.


name: High Grade Ductal Breast Carcinoma In Situ

description: Breast ductal carcinoma in situ characterized by the presence of neoplastic cells with severe dysplasia and the formation of micropapillary, cribriform, or solid patterns. The nuclei show marked pleomorphism and have prominent nucleoli. Mitotic activity is usually present. There is comedo-type of necrosis present in the ducts. The necrotic debris is surrounded by pleomorphic malignant cells.


name: Breast Carcinoma Metastatic in the Liver

description: A carcinoma that originates from the breast and has spread to the liver.


name: Unresectable HER2-Negative Breast Carcinoma

description: A HER2-negative breast adenocarcinoma that is not amenable to surgical resection.


Recurrent Breast Mucinous Carcinoma

description: The reemergence of breast mucinous carcinoma after a period of remission.


Histiocytoid Breast Carcinoma

description: A rare variant of invasive lobular breast carcinoma characterized by the presence of histiocyte-like malignant cells with pale cytoplasm forming sheets or linear patterns. Apocrine differentiation may be present. It usually has an aggressive clinical course.


name: Squamous Cell Carcinoma In Situ of the Nipple

description: An intraepidermal squamous cell carcinoma involving the area of the nipple.


malignant neoplasm of breast stage I

description: Stage I includes: IA: T1, N0, M0 and IB: (T0, N1mi, M0); (T1, N1mi, M0).  T1: Tumor 20 mm or less in greatest dimension.  T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension.  T0: No evidence of primary tumor.  N0: No regional lymph node metastasis.  N1mi: Nodal micrometastases.  M0: No clinical or radiographic evidence of distant metastasis.  M0 includes M0(i+).  (AJCC 7th Ed.)


name: Prognostic Stage 0 Breast Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0, G1-3, HER2 Status: Any, ER Status: Any, PR Status: Any. Tis: Ductal carcinoma in situ. Lobular carcinoma in situ is a benign entity and is removed from TNM staging in the AJCC Cancer Staging Manual, 8th Edition. N0: No regional lymph node metastasis is identified or isolated tumor cell clusters (ITCs) are identified only. G1: Low combined histologic grade (favorable); SBR score of 3-5 points. G2: Intermediate combined histologic grade (moderately favorable); SBR score: 6-7 points. G3: High combined histologic grade (unfavorable); SBR score of 8-9 points. M0: No clinical or radiographic evidence of distant metastases. Imaging studies are not required to assign the M0 category. (AJCC 8th ed.)


Locally Recurrent Breast Carcinoma

description: The reemergence of breast carcinoma after a period of remission, at or adjacent to the site of the original tumor.


name: Refractory HER2-Positive Breast Carcinoma

description: HER2-positive breast carcinoma that is resistant to treatment.


name: Invasive Breast Solid Papillary Carcinoma

description: Breast solid papillary carcinoma associated with areas featuring strands or large clusters of tumor cells. (WHO 2019)


Breast Florid Lobular Carcinoma In Situ

description: Breast lobular carcinoma in situ characterized by the presence of neoplastic cells with cytological features identical to classic lobular carcinoma in situ, but with marked distention of terminal ductal lobular units or ducts.


name: adenocarcinoma of breast with neuroendocrine differentiation

description: An invasive breast carcinoma characterized by the presence of focal neuroendocrine differentiation.


name: Metastatic Breast Inflammatory Carcinoma

description: Inflammatory carcinoma of the breast that has spread from its original site of growth to another anatomic site.


name: Metastatic Breast Neuroendocrine Tumor G1

description: A well differentiated neuroendocrine tumor that arises from the breast and has metastasized to other anatomic sites.


Stage IV Breast Cancer AJCC v6 and v7

description: Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 6th and 7th Eds.)


name: Unresectable Hormone Receptor-Negative Breast Carcinoma

description: Hormone receptor-negative breast carcinoma that is not amenable to surgical resection.


name: Breast Classic Lobular Carcinoma In Situ

description: Breast lobular carcinoma in situ characterized by the presence of dyscohesive proliferations of type A and/or type B epithelial cells. Type A cells are small cells with uniform hyperchromatic nuclei, whereas type B cells have slightly larger vesicular nuclei, with mild variability in size and shape and with small nucleoli. The cell populations may be mixed in individual proliferations. (WHO 2019)


Atypical Medullary Breast Carcinoma

description: An invasive ductal breast carcinoma characterized by the presence of a predominantly syncytial architectural pattern. It may have some, but not all the strictly defined additional morphologic criteria which are necessary for the diagnosis of medullary breast carcinoma (presence of a diffuse lymphoplasmacytic infiltrate, neoplastic round cells with abundant cytoplasm and vesicular nuclei, complete histological circumscription, and absence of glandular or tubular structures). It does not have the relatively favorable outcome that characterizes medullary breast carcinoma.


name: Refractory Hormone Receptor-Negative Breast Carcinoma

description: Hormone receptor-negative breast carcinoma that is resistant to treatment.


Breast Periductal Stromal Tumor

description: A rare, low-grade malignant stromal tumor that arises from the breast. It is characterized by the proliferation of atypical stromal spindle cells that surround benign tubules and ducts in a pericanalicular pattern. Mitotic activity is present. The tumor has a multinodular and infiltrative growth pattern and lacks the leaf-like architecture of phyllodes tumor. Wide excision with negative margins is the treatment of choice.


Primary angiosarcoma of breast

description: An angiosarcoma that arises from the breast parenchyma and is not associated with radiation exposure.


name: Metastatic HER2-Negative Breast Carcinoma

description: A HER2-negative breast adenocarcinoma that has spread to another anatomic site.


name: Recurrent HER2-Positive Breast Carcinoma

description: The reemergence of HER2-positive breast carcinoma after a period of remission.


Anatomic Stage 0 Breast Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Ductal carcinoma in situ. Lobular carcinoma in situ is a benign entity and is removed from TNM staging in the AJCC Cancer Staging Manual, 8th Edition. N0: No regional lymph node metastasis is identified or isolated tumor cell clusters (ITCs) are identified only. M0: No clinical or radiographic evidence of distant metastases. Imaging studies are not required to assign the M0 category. (AJCC 8th ed.)


Stage IIIC Breast Cancer AJCC v6

description: Stage IIIC Breast Cancer was added in the 6th Edition AJCC Staging Manual, on the basis of metastasis to the infraclavicular lymph nodes (N3) plus any T, M0.


name: Hormone Receptor-Positive Breast Carcinoma

description: Breast adenocarcinoma that is positive for hormone receptors.


name: Refractory Hormone Receptor-Positive Breast Carcinoma

description: Hormone receptor-positive breast adenocarcinoma that does not respond to treatment.


breast leiomyosarcoma

description: An aggressive malignant smooth muscle neoplasm, arising from the breast. It is characterized by a proliferation of neoplastic spindle cells.


Malignant nipple neoplasm male

description: A malignant neoplasm that affects the area of the nipple in males.


name: Metastatic Breast Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that arises from the breast and has metastasized to another anatomic site.


name: Inflammatory carcinoma of breast stage III

description: Inflammatory breast carcinoma is classified as AJCC Stage IIIB (T4d) unless other criteria indicate more advanced staging.


name: High Grade Breast Mucoepidermoid Carcinoma

description: An aggressive mucoepidermoid carcinoma that arises from the breast. It is characterized by the presence of focal necrosis and high mitotic activity. Lymph node and distant metastases are common. The prognosis is usually poor.


Postradiation Breast Angiosarcoma

description: A malignant vascular neoplasm arising from the skin of the breast secondary to radiation treatment for breast cancer.


name: Progesterone Receptor-Positive Breast Carcinoma

description: Breast adenocarcinoma that is positive for progesterone receptors.


name: Invasive Breast Ductal Carcinoma and Invasive Lobular Carcinoma

description: An invasive ductal breast carcinoma associated with an invasive lobular carcinomatous component.


name: Metastatic Estrogen Receptor-Positive Breast Carcinoma

description: Estrogen receptor-positive breast carcinoma that has spread from its original site of growth to another anatomic site.


Multicentric Breast Carcinoma

description: A breast carcinoma characterized by the presence of multiple cancerous tumors that originate from different clones and are usually located in different quadrants of the breast.