name: Renal Cell Carcinoma Associated with inv(X)(p11;q12)

description: A renal cell carcinoma with papillary architecture comprised of clear cells. It is characterized by the inv(X)(p11;q12) resulting in fusion of the NONO (p54nrb) and TFE3 genes.


Metastatic Kidney Carcinoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A carcinoma that arises from the kidney and has metastasized to another anatomic site.


name: Unresectable Sarcomatoid Renal Cell Carcinoma

description: A sarcomatoid renal cell carcinoma that is not amenable to surgical resection.


name: Unresectable Chromophobe Renal Cell Carcinoma

description: A chromophobe renal cell carcinoma that is not amenable to surgical resection.


name: Renal Cell Carcinoma, Not Otherwise Specified

description: A renal cell carcinoma that cannot be classified into one of the established subtypes of renal cell carcinoma.


name: Non-Hereditary Clear Cell Renal Cell Carcinoma

description: The most common type of renal cell carcinoma, characterized by a loss of genetic material of the short arm of chromosome 3.  The most common symptom at the time of diagnosis is hematuria.  The tumor has a golden-yellow color because of the abundance of intracytoplasmic lipid.  This is a clinically aggressive type of renal cell carcinoma.  The tumor usually metastasizes to unusual sites and late metastasis is common.


Stage II Renal Cell Cancer AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Lesions have been divided into T2a and T2b.  T2a is defined as tumor more than 7 cm but less than or equal to 10 cm in greatest dimension, limited to the kidney.  T2b is defined as tumor greater than 10 cm, limited to the kidney.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Renal Cell Carcinoma with Constitutional Chromosome 3 Translocations

description: A renal cell carcinoma with constitutional chromosome 3 translocations.


name: Locally Advanced Chromophobe Renal Cell Carcinoma

description: Chromophobe renal cell carcinoma that has spread to nearby tissues or lymph nodes.


name: Refractory Renal Pelvis Urothelial Carcinoma

description: Renal pelvis urothelial carcinoma that is resistant to treatment.


name: Metastatic Unclassified Renal Cell Carcinoma

description: A renal cell carcinoma, not otherwise specified, that has spread from the original site of growth to another anatomic site.


Unresectable Kidney Medullary Carcinoma

description: A kidney medullary carcinoma that is not amenable to surgical resection.


Stage III renal cell cancer

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0); (T3, N1, M0); (T3a, N0, M0); (T3a, N1, M0); (T3b, N0, M0); (T3b, N1, M0); (T3c, N0, M0); (T3c, N1, M0). T3: Tumor extends into major veins or invades adrenal gland or perinephric tissues but not beyond Gerota's fascia.  T3a: Tumor directly invades adrenal gland or perirenal and/or renal sinus fat but not beyond Gerota's fascia.  T3b: Tumor grossly extends into the renal vein or its segmental (muscle containing) branches, or vena cava below the diaphragm.  T3c: Tumor grossly extends into the vena cava above the diaphragm or invades the wall of the vena cava.  N0: No regional lymph node metastases.  N1: Metastasis in a single regional lymph node. M0: No distant metastasis.  (AJCC 6th Ed.)


Non-Clear Cell Renal Cell Carcinoma

description: A group of renal cell carcinomas characterized by the absence of lipid-containing clear adenocarcinoma cells. This category includes the following morphological subtypes: papillary renal cell carcinoma; sarcomatoid renal cell carcinoma; chromophobe renal cell carcinoma; tubulocystic renal cell carcinoma; and eosinophilic solid and cystic renal cell carcinoma.


name: Locally Recurrent Clear Cell Renal Cell Carcinoma

description: The reemergence of clear cell renal cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Renal Cell Cancer by AJCC v8 Stage

description: A term that refers to the staging of kidney cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas arising in the kidney. It does not apply to urothelial carcinomas (are staged according to the classification for renal pelvis and ureter), lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), sarcomas (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs), and Wilms tumor (no AJCC staging system). (from AJCC 8th Ed.)


name: Childhood SMARCB1-Deficient Kidney Medullary Carcinoma

description: A SMARCB1-deficient kidney medullary carcinoma that occurs during childhood.


Metastatic Renal Pelvis Carcinoma

description: Renal pelvis carcinoma that has spread from the original site of growth to other anatomic sites.


name: Metastatic Papillary Renal Cell Carcinoma

description: A papillary renal cell carcinoma that has spread from the original site of growth to another anatomic site.


name: Early Stage Clear Cell Renal Cell Carcinoma

description: A stage term referring to clear cell renal cell carcinoma that presents as a small tumor and is confined to the kidney.


Stage II Renal Cell Cancer

description: Stage II includes: T2, N0, M0.  T2: Tumor more than 7 cm in greatest dimension limited to the kidney.  N0: No regional lymph node metastases.  M0: No distant metastasis. (AJCC 6th Ed.)


Recurrent Kidney Medullary Carcinoma

description: The reemergence of kidney medullary carcinoma after a period of remission.


name: Renal Cell Carcinoma Associated with t(X;1)(p11.2;q21)

description: A renal cell carcinoma with papillary architecture comprised of clear cells. It is characterized by the t(X;1)(p11.2;q21) resulting in fusion of the PRCC and TFE3 genes.


Renal Pelvis Cancer by AJCC v7 Stage

description: A term that refers to the staging of renal pelvis cancer according to the American Joint Committee on Cancer, 7th edition.


Refractory Kidney Medullary Carcinoma

description: A kidney medullary carcinoma that does not respond to treatment.


Refractory Renal Cell Carcinoma

description: Renal cell carcinoma that does not respond to treatment.


Grade 3 Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma characterized by nucleoli conspicuous and eosinophilic at x 100 magnification. (WHO 1982 /ISUP 2014)


Locally Advanced Renal Cell Carcinoma

description: Renal cell carcinoma that has spread to nearby tissues or lymph nodes.


Stage III Renal Pelvis Cancer AJCC v8

description: Stage III includes: T3, N0, M0. T3: Tumor invades beyond muscularis into peripelvic fat or into the renal parenchyma. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Transplant-Related Renal Cell Carcinoma

description: A renal cell carcinoma that arises in a patient with a history of organ transplantation.


Stage IV Renal Cell Cancer

description: Stage IV includes: (T4, N0, M0); (T4, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invades beyond Gerota's fascia.  N0: No regional lymph node metastases.  N1: Metastasis in a single regional lymph node.  N2: Metastasis in more than one regional lymph node.  M0: No distant metastasis. M1: Distant metastasis. (AJCC 6th ed.)


ELOC-Mutated Renal Cell Carcinoma

description: A renal cell carcinoma characterized by the presence of mutations in the ELOC (TCEB1)  gene at 8q21.11.


name: Renal Cell Carcinoma Associated with t(X;1)(p11.2;p34)

description: A renal cell carcinoma with papillary architecture comprised of clear cells. It is characterized by the t(X;1)(p11.2;p34) resulting in fusion of the PSF and TFE3 genes.


Renal Cell Cancer by AJCC v6 Stage

description: A term that refers to the staging of renal cell cancer according to the American Joint Committee on Cancer, 6th edition.


Kidney Carcinoma Molecular Subtypes

description: A term that refers to the classification of kidney carcinomas according to their molecular characteristics.


name: Succinate Dehydrogenase-Deficient Renal Cell Carcinoma

description: A very rare renal cell carcinoma that usually affects young adults. It is characterized by mutations in one of the four subunits of the SDH complex (SDHA, SDHB, SDHC, or SDHD gene). Most frequently, the mutations occur in the SDHB subunit. It has a relatively good prognosis.


Unresectable Renal Cell Carcinoma

description: A renal cell carcinoma that is not amenable to surgical resection.


Stage IV Renal Cell Cancer AJCC v7

description: Stage IV includes: (T4, Any N, M0); (Any T, Any N, M1). T4: Tumor invades beyond Gerota's fascia (including contiguous extension into the ipsilateral adrenal gland).  M0: No distant metastasis. M1: Distant metastasis. (AJCC 7th ed.)


Grade 2 Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma characterized by nucleoli conspicuous and eosinophilic at x 400 magnification, and visible but not prominent at x 100 magnification. (WHO 1982 /ISUP 2014)


Grade 1 Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma characterized by absent or inconspicuous and basophilic nucleoli at x 400 magnification. (WHO 1982 /ISUP 2014)


Locally Advanced Renal Pelvis Carcinoma

description: Renal pelvis carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Locally Advanced Kidney Carcinoma

description: Kidney carcinoma that has spread to nearby tissues or lymph nodes.


Renal cell carcinoma recurrent

description: A reemergence of renal cell carcinoma after a period of remission.


Metastatic Renal Cell Carcinoma

description: Renal cell carcinoma that has spread from the kidney to other anatomic sites.


Localized Renal Cell Carcinoma

description: A renal cell carcinoma that is mainly confined to the kidney with or without involvement of perinephric tissues and without evidence of spread to other organs.


Kidney Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the kidney. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Stage IV Renal Pelvis Cancer AJCC v7

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into perinephric fat.  N0: No regional lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis. (AJCC 7th ed.)


name: Locally Advanced Sarcomatoid Renal Cell Carcinoma

description: Sarcomatoid renal cell carcinoma that has spread to nearby tissues or lymph nodes.


name: Recurrent Clear Cell Renal Cell Carcinoma

description: The reemergence of clear cell renal cell carcinoma after a period of remission.


name: Unresectable Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma that is not amenable to surgical resection.


Stage III Renal Cell Cancer AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0); (T3, N1, M0). T1: Tumor measuring 7 cm or less in greatest dimension, limited to the kidney. T2: Tumor measuring more than 7 cm in greatest dimension, limited to the kidney. T3: Tumor extending into major veins or perinephric tissues, but not into the ipsilateral adrenal gland and not beyond Gerota's fascia. N0: No regional lymph node metastasis. N1: Metastasis in regional lymph node(s). M0: No distant metastasis. (AJCC 8th ed.)


Renal Cell Cancer by AJCC v7 Stage

description: A term that refers to the staging of renal cell cancer according to the American Joint Committee on Cancer, 7th edition.


Stage I Renal Pelvis Cancer AJCC v7

description: Stage I includes: T1, M0, M0.  T1: Tumor invades subepithelial connective tissue.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Childhood ALK-Rearranged Renal Cell Carcinoma

description: An ALK-rearranged renal cell carcinoma that occurs during childhood.


Refractory Kidney Carcinoma

description: Kidney carcinoma that is resistant to treatment.


name: N-[[2-(1-piperidinyl)-4-thiophen-2-yl-5-thiazolyl]methylideneamino]carbamic acid methyl ester


Category:Glycerolipids - Main Class:Glycosyldiradylglycerols - Subclass:Glycosyldiacylglycerols (Digalactosyldiacylgylcerols) - Abbreviation:DGDG


CYHALOTHRIN

A carboxylic ester obtained by formal condensation between 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol.


lambda-cyhalothrin

Reaction product comprising equal quantities of CHEBI:39323 and CHEBI:39327.


QUINIZARIN

A dihydroxyanthraquinone having the two hydroxy substituents at the 1- and 4-positions; formally derived from anthraquinone by replacement of two hydrogen atoms by hydroxy groups


copper(I) chloride

An inorganic chloride of copper in which the metal is in the +1 oxidation state.


copper sulfide

Compounds with the general formula CuxSy.


chalcopyrite

A sulfide mineral with formula CuFeS2. Chalcopyrite is the most important copper ore


copper(II) sulfide

A copper sulfide in which the metal is in the +2 oxidation state.


The stable isotope of copper with relative atomic mass 62.929601, 69.2 atom percent natural abundance and nuclear spin 3/2.


name: heptakis-L-histidino tetracopper mu4-sulfide hydroxide


elesclomol-Cu(II)

The copper coordination entity formed from elesclomol by coordination to copper via the thiocarbonyl and hydrazino groups.


cupric chloride

An inorganic chloride of copper in which the metal is in the +2 oxidation state.


copper(I) sulfide

A copper sulfide in which the metal is in the +1 oxidation state.


copper-sulfur cluster

A copper-sulfur cluster is a unit comprising two or more copper atoms and bridging sulfur ligand(s).


An ion of copper carrying a double positive charge.


A 1-acyl-sn-glycero-3-phosphoethanolamine zwitterion obtained by transfer of a proton from the amino to the phosphate group of 1-oleoyl-sn-glycero-3-phosphoethanolamine.


A lysophosphatidylethanolamine zwitterion in which the remaining acyl group (position not specified) contains 18 carbons and 1 double bond.


A 2-acyl-sn-glycero-3-phosphoethanolamine zwitterion obtained by transfer of a proton from the phosphate to the amino group of 2-oleoyl-sn-glycero-3-phosphoethanolamine; major species at pH 7.3.


A lysophosphatidylethanolamine zwitterion in which the remaining acyl group (position not specified) contains an oleoyl chain.


An oxoicosatetraenoic acid that is (5Z,8Z,12E,14Z)-icosatetraenoic acid bearing a single oxo substituent located at position 12.


A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N(1)-[3-(4-bromophenyl)prop-2-en-1-yl]ethane-1,2-diamine. It is a protein kinase A inhibitor.


A N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide in which the double bond adopts a trans-configuration.


name: Invasive Adenocarcinoma in Adenomatous Polyp

description: An invasive adenocarcinoma that arises in an adenomatous polyp.


6 thioguanosine triphosphate(4-)

A pharmacologically active metabolite of azathioprine


DEOXYGUANOSINE

A purine 2'-deoxyribonucleoside having guanine as the nucleobase.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,7Z,23Z)-dotetracontatrienoyl.


An O-(S-acylpantetheine-4'-phosphoryl)serine(1-) residue arising from deprotonation of the phosphate group of any O-[S-(2E)-enoylpantetheine-4'-phosphoryl]-L-serine residue; major species at pH 7.3.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,19Z)-octatriacontadienoyl.


An O-(S-acylpantetheine-4'-phosphoryl)serine(1-) residue in which the S-acyl group is specified as (2E)-decenoyl.


An O-(S-acylpantetheine-4'-phosphoryl)serine(1-) residue in which the S-acyl group is specified as (2E)-hexenoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,23Z,39Z)-octapentacontatrienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,13Z,29Z)-octatetracontatrienoyl.


An O-(S-(2E)-enoylpantetheine-4'-phosphoryl)-L-serine(1-) residue in which the S-acyl group is specified as (2E)-octenoyl; major species at pH 7.3.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,17Z,33Z)-dopentacontatrienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E)-icosenoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,9Z,25Z)-tetratetracontatrienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,5Z)-hexacosadienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,19Z,31Z)-pentacontatrienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,21Z,37Z)-hexapentacontatrienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,4E)-hexadienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,11Z,27Z)-hexatetracontatrienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,11Z,23Z)-dotetracontatrienoyl.


An O-(S-acylpantetheine-4'-phosphoryl)serine(1-) residue in which the S-acyl group is specified as (2E)-octadecenoyl.


An O-(S-acylpantetheine-4'-phosphoryl)serine(1-) residue in which the S-acyl group is specified as (2E)-butenoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,19Z,35Z)-tetrapentacontatrienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,15Z,31Z)-pentacontatrienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,17Z,29Z)-octatetracontatrienoyl.


An O-(S-acylpantetheine-4'-phosphoryl)-L-serine(1-) residue in which the S-acyl group is specified as (2E,9Z)-hexadecadienoyl; major species at pH 7.3.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,5Z,17Z)-hexatriacontatrienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,11Z)-triacontadienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,17Z)-hexatriacontadienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,15Z)-tetratriacontadienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,5Z)-tetracosadienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,9Z,21Z)-tetracontatrienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,13Z,25Z)-tetratetracontatrienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E)-docosenoyl.


An O-(S-acylpantetheine-4'-phosphoryl)serine(1-) residue in which the S-acyl group is specified as (2E)-dodecenoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,5Z,21Z)-tetracontatrienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue  in which the S-acyl group is specified as (2E)-isoheptenoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,13Z)-dotriacontadienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,9Z)-octacosadienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,7Z,19Z)-octatriacontatrienoyl.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,5Z)-dodecadienoyl; major species at pH 7.3.


An O-[S-(2E)-2-enoylpantetheine-4'-phosphoryl]-L-serine(1-) residue in which the S-acyl group is specified as (2E,15Z,27Z)-hexatetracontatrienoyl.


escitalopram

A 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has S-configuration at the chiral centre. It is the active enantiomer of citalopram.


poly(butyl methacrylate) macromolecule

A macromolecule composed of repeating butyl isobutyrate units.


A long-chain fatty alcohol that is pentadecane in which one of the terminal methyl hydrogens is replaced by a hydroxy group


A 1,2-diacyl-sn-glycero-3-phosphoethanolamine zwitterion in which the acyl groups at C-1 and C-2 contain 44 carbons in total with 4 double bonds.


An amino tetrasaccharide consisting of alpha-L-fucose, beta-D-galactose, N-acetyl-alpha-D-galactosamine and alpha-D-galactose residues joined in sequence with (1->2)-, (1->3)- and (1->3)-linkages, respectively.


valienone 7-phosphate

A hydroxyalkyl phosphate that is valienone carrying a single monophosphate substituent at position 7.


2,3-saturated fatty acid

Any fatty acid in which the first two carbons of the chain attached to the carboxy group are saturated and unbranched.


A  dihydroxyflavanone that is pinocembrin substituted by a methyl group at position 8. It has been isolated from the buds of Cleistocalyx operculatus.


An amino nonasaccharide consisting of a tetrasaccharide chain of N-acetyl-beta-D-glucosamine, beta-D-mannose, N-acetyl-beta-D-glucosamine and N-acetyl-D-glucosamine residues, all linked sequentially (1->4), to the beta-D-mannose residue of which are also linked N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl and N-acetyl-beta-D-glucosaminyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->2)]-alpha-D-mannosyl units via (1->6) and (1->3) linkages respectively.


The acetate ester of benzyl alcohol.


tideglusib

A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy.


name: paneth cell of epithelium proper of small intestine

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A Paneth cell that is part of the epithelium proper of small intestine.


Major species at pH 7.3. The compound is seen in the ref., Fig. 5 just left of 2'-O-AADPR. It is also compound IV in Fig. 6


A sphingoid 1-phosphate that is hexadecasphing-4-enine substituted by a phospho group at position 1.


A methyl ketone heptan-2-one carrying a double bond at position 4.


UMP 2',3'-cyclic phosphate(2-) residue

An organic anionic group obtained by deprotonation of the phosphate OH groups of UMP 2',3'-cyclic phosphate residue


A 3-(difluoromethyl)-N-(9-isopropyl-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl)-1-methylpyrazole-4-carboxamide that is the syn-(1S,4R,9S)-diastereomer of isopyrazam.


raltegravir

A pyrimidone that is pyrimidin-4(3H)-one in which the hydrogens at positions 2, 3, 5 and 6 are replaced by 2-[(5-methyl-1,3,4-oxadiazole-2-carbonyl)amino]propan-2-yl, methyl, hydroxy, and N-[(4-fluorophenyl)methyl]aminoacyl groups, respectively. It is an antiretroviral drug used for treatment of HIV infection.


name: Gallbladder Intracholecystic Papillary Neoplasm, High Grade

description: An intracholecystic papillary neoplasm that arises from the epithelium of the gallbladder. It is characterized by the presence of severe epithelial atypia.


Gestational diabetes mellitus class A1

description: Carbohydrate intolerance first diagnosed during pregnancy. Diagnosis from abnormal oral glucose tolerance test (OGTT) but normal glucose levels when fasting and two hours post-prandial. Euglycemia achieved with diet and/or exercise.


Carcinomatosis of peritoneal cavity

description: A condition in which a carcinoma has spread extensively throughout the peritoneum.


name: Childhood Acute Myeloid Leukemia with Maturation

description: An acute myeloid leukemia with maturation occurring in children.


Type B Lymphomatoid Papulosis

description: A variant of lymphomatoid papulosis characterized by an epidermotropic infiltrate composed of small atypical cerebriform-like lymphocytes.


name: Diffuse Pediatric-Type High Grade Glioma MYCN

description: An aggressive, WHO grade 4 diffuse glioma usually affecting children, adolescents, or young adults. It is characterized by the expression of MYCN molecular signature.


Retropharyngeal Abscess

description: An abscess that develops in the soft tissues behind the posterior pharyngeal wall.


Factor IX Inactivation

description: Presence of inactivating antibodies to factor IX in the blood.


Benign neoplasm of adnexa of skin

description: A neoplasm that arises from the hair follicles, sebaceous glands, or sweat glands. It is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include cylindroma, hidrocystoma, hidradenoma, and sebaceoma.


Adult Grade I Meningioma

description: A grade I meningioma that occurs during adulthood.


name: Recurrent Lymphocyte-Rich Classic Hodgkin Lymphoma

description: The reemergence of lymphocyte-rich classic Hodgkin lymphoma after a period of remission.


name: High Grade Appendix Mucinous Adenocarcinoma

description: A mucinous adenocarcinoma that arises from the appendix. The malignant cells are numerous and exhibit high grade dysplasia.  It may be associated with pseudomyxoma peritonei, but unlike the low grade mucinous neoplasm, it invades other organs and metastasizes to distant anatomic sites.


Recurrent Malignant Abdominal Neoplasm

description: The reemergence of a malignant abdominal neoplasm after a period of remission.


Adult Classical Hodgkin Lymphoma

description: Classic Hodgkin lymphoma that occurs in adults.


name: Childhood Acute Lymphoblastic Leukemia CNS 1 Toronto Guidelines v2

description: No clinical signs of CNS involvement and no blasts in CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Adenomatous hyperplasia

description: Proliferation of the glandular epithelial cells.


Stage IIB Appendix Carcinoma AJCC v8

description: Stage IIB includes: T4a, N0, M0. T4a: Tumor invades through the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or serosa of the mesoappendix. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Posterior Subcapsular Cataract Grade 4

description: A stage of posterior subcapsular cataract characterized by greater than 50% of the posterior capsule obscured by opacity. (Modified LOCS II)


name: Stage IIA Gestational Trophoblastic Tumor AJCC v7

description: Stage IIA includes: T2, M0, Risk factors: low risk.  T2: Tumor extends to other genital structures (ovary, tube, vagina, broad ligaments) by metastasis or direct extension.  M0: No distant metastasis.  (AJCC 7th ed.)


Adult Giant Cell Glioblastoma

description: A giant cell glioblastoma occurring in adults.


Moderate Cardiac Valve Regurgitation

description: Evidence of moderate retrograde blood flow through the valve(s) of the heart. (ACC)


Recurrent Anal Adenocarcinoma

description: The reemergence of anal adenocarcinoma after a period of remission.


Recurrent tumor

description: The reemergence of a neoplasm after a period of remission.


Drug Induced Thrombocytopenia

description: Thrombocytopenia caused by ingested or injected drugs. It may be the result of decreased platelet production due to bone marrow suppression or increased rate of platelet destruction.


Metastatic malignant neoplasm to vagina

description: A malignant neoplasm that has spread to the vagina from another anatomic site.


name: Ampulla of Vater Cancer by AJCC v8 Stage

description: A term that refers to the staging of ampulla of Vater cancer according to the American Joint Committee on Cancer, 8th edition. This staging system does not apply to well-differentiated neuroendocrine (carcinoid) tumors but does apply to high-grade neuroendocrine carcinomas, such as small cell carcinoma and large cell neuroendocrine carcinoma. (from AJCC 8th Ed.)


name: Recurrent Malignant Spermatic Cord Neoplasm

description: The reemergence of a malignant spermatic cord neoplasm after a period of remission.


name: Malignant Non-Hodgkin's Lymphoma, Small Cleaved Cell


Invasive Cutaneous Melanoma

description: A melanoma of the skin that is not confined to the dermal-epidermal junction, and has infiltrated the dermis.


Mediastinal Diseases

description: A non-neoplastic or neoplastic disorder that affects the structures of the mediastinum.  Representative examples include mediastinitis, mediastinal lipoma, mediastinal schwannoma, thymoma, and mediastinal lymphoma.


name: FIGO Stage I Gestational Trophoblastic Tumor

description: Lesion is confined to the uterus.


Recurrent Gliomatosis Cerebri

description: The reemergence of gliomatosis cerebri after a period of remission.


Lacrimal Gland Oncocytoma

description: A benign epithelial neoplasm that arises from the lacrimal gland. It is characterized by the presence of oncocytic cells with abundant eosinophilic and granular cytoplasm.


Fallopian Tube Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the fallopian tube.  Representative examples include acute and chronic salpingitis, salpingitis isthmica nodosa, and endometriosis.


Prosthetic valve endocarditis

description: Endocarditis occurring on parts of a valve prosthesis or a reconstructed heart valve; it can be classified into early and late prosthetic valve endocarditis.


name: Primary cutaneous CD4 positive small/medium T-cell lymphoproliferative disorder

description: A primary cutaneous T-cell lymphoproliferative disorder.  It usually presents with a solitary plaque or tumor on the face, neck, or upper trunk.  Morphologically, it is composed of small to medium-sized CD4-positive, CD8-negative, and CD30-negative pleomorphic T-lymphocytes.  A small number of large pleomorphic T-lymphocytes may also be present.  The lymphocytic infiltrate is dermal.  Focal epidermotropism and subcutaneous involvement may be present.  The clinical behavior is almost always indolent and most patients present with localized disease.


name: Infection by methicillin sensitive Staphylococcus aureus

description: A bacterial infection that is caused by Staphylococcus aureus that is susceptible to methicillin.


Refractory Leukemia

description: Leukemia that is resistant to treatment.


name: Locally Advanced Unresectable Malignant Neoplasm

description: A malignant neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Childhood Diffuse Astrocytoma

description: A diffuse astrocytoma that occurs during childhood.


Stage IIIC Vulvar Cancer AJCC v8

description: Stage IIIC includes: T1-T2, N2c, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N2c: Lymph node(s) metastasis with extranodal extension. M0: No distant metastasis. (AJCC 8th Ed.)


name: Low Grade Conjunctival Melanocytic Intraepithelial Lesion

description: Conjunctival melanocytic intraepithelial lesion characterized by the presence of mild atypia.


name: MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1C

description: A sub-type of limb-girdle muscular dystrophy caused by mutation(s) in the CAV3 gene, encoding caveolin-3.


name: congenital malformation syndromes due to known exogenous causes

description: A syndrome characterized by the presence of structural malformations that are present at birth and can be attributed to an exogenous cause.


Adenocarcinoma of Unknown Primary

description: An adenocarcinoma which has metastasized from an unknown primary anatomic site.


name: Low Grade Prostatic Intraepithelial Neoplasia

description: Prostatic intraepithelial neoplasia characterized by the proliferation of secretory cells with irregular spacing in the ducts and acini.  Although some proliferating epithelial cells may contain prominent nucleoli, the cytologic atypia and architectural growth patterns that are seen in the high grade prostatic intraepithelial neoplasia are absent.  The presence of low grade prostatic intraepithelial neoplasia in needle biopsy is not a risk factor for the subsequent detection of carcinoma on repeat biopsy.


name: Stage IV Ampulla of Vater Cancer AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Recurrent WHO Grade 2 Glioma

description: The reemergence of WHO grade 2 glioma after a period of remission.


Recurrent Glioma

description: The reemergence of a glioma after a period of remission.


name: Adult Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1

description: An acute myeloid leukemia with t(8;21)(q22; q22.1); RUNX1-RUNX1T1 occurring in adults.


leather-bottle stomach

description: A cancer-related condition in which the gastric wall becomes thickened and rubbery (leather-bottle stomach). It is most often associated with diffuse gastric adenocarcinomas.


name: Pathologic Stage IIB Merkel Cell Carcinoma AJCC v8

description: Stage IIB includes: T4, N0, M0. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Paratesticular Well Differentiated Papillary Mesothelial Tumor

description: A rare, indolent, usually solitary mesothelial neoplasm that arises from the tunica vaginalis. It is characterized by the presence of a papillary architecture in which the papillae are lined by cuboidal mesothelial cells. Mitotic figures are usually absent. Stromal invasion is absent or minimal. It usually manifests with a hydrocele and less frequently scrotal mass.


Herpes esophagitis

description: Esophagitis resulting from exposure to herpes virus.


Stage IIIB Cervical Cancer AJCC v9

description: Stage IIIB includes: T3b, N0, M0. T3b: Tumor extending to pelvic wall and/or causing hydronephrosis or nonfunctioning kidney (unless known to be due to another cause). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Bone Epithelioid Hemangioendothelioma

description: A low-grade malignant blood vessel neoplasm arising from the bone.  It is characterized by the presence of epithelioid endothelial cells.  The neoplastic cells are arranged in cords and nests, which are embedded in a myxoid to hyalinized stroma.


Bladder Cancer by AJCC v8 Stage

description: A term that refers to the staging of bladder cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas arising in the bladder. The typical carcinoma of the bladder is urothelial carcinoma. These carcinomas may include other histologic elements, including adenocarcinoma, squamous cell carcinoma, and small cell neuroendocrine carcinoma, but should be classified as urothelial unless the cancer is composed entirely of the alternative histology. All histologic cell types that are derived primarily from the urinary bladder epithelium should follow this staging system. It does not apply to prostatic urothelial carcinomas (are staged according to the classification for urethra), lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and sarcomas (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs).  (from AJCC 8th Ed.)


Bronchial Fistula

description: An abnormal communication between the bronchus and another organ or anatomic site.


name: Advanced Gastric Large Cell Neuroendocrine Carcinoma

description: A gastric large cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Type IV Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the right and left pulmonary arteries drain into different sites.


name: Refractory Endometrial Mucinous Adenocarcinoma

description: Endometrial mucinous adenocarcinoma that is resistant to treatment.


Adenocarcinoma of the prostate stage I

description: Stage I includes: (T1a-c, N0, M0, PSA less than 10, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 10, Gleason equal or less than 6); (T1-2a, N0, M0, PSA X, Gleason X).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less. cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason X: Gleason score cannot be processed.  (AJCC 7th ed.)


Stage IA Bone Cancer AJCC v7

description: Stage IA includes: T1, N0, M0, G1, G2, GX.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


lymphomatoid papulosis, type A

description: A variant of lymphomatoid papulosis characterized by the presence of scattered anaplastic large lymphocytes, often resembling Reed-Sternberg cells, admixed with acute and chronic inflammatory cells.


Intra-Abdominal Paraganglioma

description: An extra-adrenal paraganglioma arising from the abdominal cavity.


name: Pancreatic Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of a pancreatic neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to well-differentiated neuroendocrine tumors arising in the pancreas. Carcinomas of the pancreas, including high-grade (grade 3), poorly differentiated neuroendocrine carcinomas are not staged using this staging system. (from AJCC 8th Ed.)


name: Adult Dysembryoplastic Neuroepithelial Tumor

description: A dysembryoplastic neuroepithelial tumor that occurs during adulthood.


Stage III Gallbladder Cancer AJCC v7

description: Stage III includes: IIIA (T3, N0, M0); IIIB (T1-3, N1, M0). T3: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts.  T1: Tumor invades lamina propria or muscular layer.  T2: Tumor invades perimuscular connective tissue; no extension beyond serosa or into liver. N0: No regional lymph node metastasis.  N1: Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Non-T Non-B CALLA Negative Adult Acute Lymphoblastic Leukemia

description: Non-T non-B, CALLA negative acute lymphoblastic leukemia that occurs during adulthood.


name: Metastatic Human Papillomavirus-Related Malignant Neoplasm

description: A malignant neoplasm that is associated with human papillomavirus infection and has spread from its original site of growth to another anatomic site.


Adult Ependymal Tumor

description: An ependymal tumor of the central nervous system occurring in adults.


Impatent structure

description: A congenital anatomic defect characterised by the absence of a normally present opening in an organ or tissue.


Stage IIIA Appendix Carcinoma AJCC v7

description: Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. N1: Metastasis in 1-3 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


P3 Hydronephrosis

description: Postnatal Hydronephrosis with the following clinical findings: 1) calyceal dilation and the ureter are the same as those in UTD P2, 2) the renal parenchymal is thinned, has increased echogenicity and/or has decreased corticomedullary differentiation, or 3) the bladder is abnormal (wall thickening, ureterocele, posterior urethral dilation). Cases in which there are parenchymal abnormalities but the APRPD is less than 15 mm, are classified as UTD P3. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


name: Primary Intraosseous Squamous Cell Carcinoma-Solid Type

description: A non-keratinizing or keratinizing squamous cell carcinoma that arises centrally from the jaw.  It is characterized by a solid pattern, infiltration of the marrow spaces, and osseous resorption.


Ureter Urothelial Carcinoma, High Grade

description: Ureter urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


name: Stage IIIC2 Uterine Corpus Cancer AJCC v8

description: Stage IIIC2 includes: T1-T3, N2/N2mi/N2a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2mi: Regional lymph node metastasis (greater than 0.2 mm but not greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


Stage II Childhood Large Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Familial Catecholamine-Induced QT Prolongation

description: A familial phenotype characterized by a normal QT interval at rest, but major QT lengthening during catecholergic stimulation.


name: Testicular Sex Cord-Gonadal Stromal Tumor, Incompletely Differentiated

description: A sex cord-stromal tumor of the testis in which the neoplastic cells do not show specific differentiation.


name: Refractory Microsatellite Stable Endometrial Carcinoma

description: Microsatellite stable endometrial carcinoma that is resistant to treatment.


Malignant lymphoma, diffuse

description: An antiquated term referring to non-Hodgkin lymphomas with a diffuse architectural pattern.


name: Retinopathy of Prematurity with Plus Disease

description: A stage of retinopathy of prematurity characterized by the presence of the following in at least two quadrants around the optic nerve: dilation and tortuosity of major retinal vasculature as a result of increased blood flow.


name: Ampulla of Vater Undifferentiated Carcinoma with Osteoclast-Like Giant Cells

description: A rare variant of undifferentiated carcinoma that arises from the ampulla of Vater. It is characterized by the presence of non-neoplastic, histiocytic, osteoclast-like multinucleated giant cells.


name: High-Grade Squamous Intraepithelial Lesions

description: A precancerous neoplastic process characterized by the presence of moderate or severe dysplastic cytological changes which extend to the upper part of the squamous epithelium.  Maturation at the surface of the squamous epithelium may or may not be present.  Representative examples include the high grade esophageal squamous intraepithelial neoplasia, high grade cervical squamous intraepithelial neoplasia, high grade vaginal intraepithelial neoplasia, and high grade vulvar intraepithelial neoplasia.


name: Solar Radiation-Related Skin Squamous Cell Carcinoma

description: A squamous cell carcinoma arising in a skin site exposed to solar radiation.


name: Reactive attachment disorder of infancy or early childhood

description: A condition in which the failure to establish healthy bonds with caregivers in early childhood leads to lifelong impairment of social interactions.


name: Locally Advanced Malignant Solid Neoplasm

description: A malignant solid neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Sexually Transmitted Chlamydial Disease

description: A chlamydial infection that was sexually transmitted.


name: Recurrent Malignant Genitourinary System Neoplasm

description: The reemergence of a malignant genitourinary system neoplasm after a period of remission.


Unresectable Gastric Adenocarcinoma

description: A gastric adenocarcinoma that is not amenable to surgical resection.


Enteropathogenic E coli Infection

description: A pathotype of Escherichia coli, which is a gram-negative bacteria that is transmitted through the fecal-oral route. It has an incubation period of 9-12 hours and a duration of 12 days. Symptoms may include persistent severe acute diarrhea.


Biliary Fistula

description: An abnormal communication between the bile ducts and another organ or cavity.


Spindle Cell/Pleomorphic Lipoma

description: A benign lipomatous neoplasm characterized by the presence of an admixture of mature adipose tissue and bland spindle cells.  The pleomorphic variant contains in addition multinucleated giant cells.  It usually arises in the neck and upper trunk in older males.


name: Stage IIIC1 Uterine Corpus Cancer AJCC v7

description: Stage IIIC1 includes: T1-T3, N1, M0.  T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. N1: Regional lymph node metastasis to pelvic lymph nodes. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Stage II Skin Cancer

description: Stage II includes: T2, N0, M0.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  High-risk features for the primary tumor staging are defined as follows: depth/invasion of more than 2 mm thickness; Clark level equal or greater than IV; and perineural invasion.  Anatomic location: primary site ear and primary site non-hair-bearing lip.  Differentiation: poorly differentiated or undifferentiated.  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th ed.)


Refractory Pseudomyxoma Peritonei

description: Pseudomyxoma peritonei that is resistant to treatment.


Condylomatous carcinoma

description: A squamous cell carcinoma characterized by a papillary growth pattern, hyperkeratosis, and koilocytosis.


Advanced Glioblastoma

description: Glioblastoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Corn of toe

description: A thickening of the skin due to friction or pressure which results in the formation of a small, painful, raised bump associated with a conical mass pointing down into the dermis.


name: K ATP Channel-Associated Diabetes Mellitus

description: Diabetes mellitus caused by activating mutation(s) in genes (KNCJ11 and/or ABCC8) encoding either of the 2 proteins (Kir6.2 and/or SUR1) that make up the pancreatic beta cell adenosine triphosphate-sensitive potassium channel, which is crucial for the regulation of glucose-induced insulin secretion.


name: Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8

description: Stage IIIA includes: (T1, N2, M0, Any G); (T2, N1, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Recurrent Malignant Choroid Plexus Neoplasm

description: The reemergence of a malignant choroid plexus neoplasm after a period of remission.


name: Extrahepatic Bile Duct Biliary Intraepithelial Neoplasia

description: A neoplastic, non-invasive lesion that affects the extrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


Regressed germ cell tumor

description: A testicular germ cell tumor that has undergone either partial or complete regression, resulting in the creation of a fibrotic nodule in the testis.


Neuroendocrine Tumor G1

description: A well-differentiated, low-grade epithelial neoplasm with neuroendocrine differentiation. It arises from multiple sites, including the digestive system, lung, and head and neck.


name: AIDS-Related Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease

description: Diffuse large B-cell lymphoma arising in HHV8-positive multicentric Castleman disease occurring in HIV-positive patients.


name: Vulvar Squamous Cell Carcinoma with Tumor Giant Cells

description: An aggressive squamous cell carcinoma that arises from the vulva and is characterized by the prominence of malignant giant cells.


Neoplasms, Therapy-Associated

description: The development of a neoplasm in response to medical or surgical treatment, induced by the treatment itself.


Prevertebral Abscess

description: An abscess that develops in the tissues within the prevertebral fascia.


Unresectable Esophageal Adenocarcinoma

description: Esophageal adenocarcinoma that is not amenable to surgical resection.


Stage II Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Non-Severe Aplastic Anemia

description: Aplastic anemia that is characterized by bone marrow cellularity less than 30% and does not meet criteria for severe aplastic anemia.


Acquired Bilateral Cataracts

description: Cataracts in both eyes that result from the aging process, an injury, or as a manifestation of a systemic disorder.


Gastric Fistula

description: An abnormal communication between the stomach and another organ or anatomic site.


Diabetes mellitus without complication

description: Diabetes mellitus that does not show any evidence of tissue or organ damage.


name: Stage IA Ampulla of Vater Cancer AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Advanced Sarcoma of the Extremity

description: A sarcoma of the soft tissues or bones of the upper or lower extremity that has spread extensively to other anatomic sites or is no longer responding to treatment.


Serous Tubal Intraepithelial Carcinoma

description: A non-invasive serous carcinoma arising from the fallopian tube.


Age-Related Clonal Hematopoiesis

description: The gradual, clonal expansion of hematopoietic stem and progenitor cells carrying specific, disruptive, and recurrent genetic variants, in individuals without clear diagnosis of hematological malignancies. It is associated with an increased risk of developing hematologic cancers.


Secondary Cerebral Hodgkin Lymphoma

description: A Hodgkin lymphoma that has spread to the cerebral hemisphere following the initial presentation in another nodal or extranodal site.


Lesion

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A localized pathological or traumatic structural change, damage, deformity, or discontinuity of tissue, organ, or body part.


Borderline Peritoneal Serous Tumor

description: A serous epithelial tumor that arises from the peritoneum and histologically resembles the serous borderline tumors that arise from the ovary.


name: Pathologic Stage IIC Cutaneous Melanoma AJCC v8

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Metastatic malignant neoplasm to urethra

description: A malignant neoplasm that has spread to the urethra from another anatomic site.


Broncho-esophageal fistula

description: An abnormal connection between a bronchus and the esophagus.


Inflammatory Hepatocellular Adenoma

description: A hepatocellular adenoma that occurs more often in women.  It is characterized by increased levels of inflammation-associated proteins.  It is usually associated with steatosis and obesity.


Non-Obstructed Megaureter

description: A megaureter in which there is no obstruction at the ureterovesical junction.


name: Refractory Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma that is resistant to treatment.


Stage III Uterine Corpus Cancer AJCC v8

description: Stage III includes: T3, N0, M0. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Unresectable Anal Canal Squamous Cell Carcinoma

description: Anal canal squamous cell carcinoma that is not amenable to surgery.


Urinary System Carcinoma

description: A malignant neoplasm that arises from the epithelium of any part of the urinary system. Representative examples include kidney carcinoma and bladder carcinoma.


Recto-Vesico-Vaginal Fistula

description: An abnormal communication between the rectum, bladder, and vagina.


Broad Ligament Serous Adenofibroma

description: A rare serous adenofibroma arising from the broad ligament.


description: An adenocarcinoma associated with the presence of human papillomavirus infection.


Refractory T-Cell and NK-Cell Neoplasm

description: T-cell and NK-cell neoplasm that is resistant to treatment.


Recurrent Primary Cutaneous Lymphoma

description: The reemergence of primary cutaneous lymphoma after a period of remission.


Asymptomatic Infections

description: Infection associated with no detectable symptoms but caused by microorganisms capable of producing easily recognizable diseases, such a poliomyelitis or mumps.


Stage IIB Bone Cancer AJCC v8

description: Stage IIB includes: T2, N0, M0, G2 or G3. T2: Tumor measuring more than 8 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


Advanced Ocular Melanoma

description: Ocular melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Tectal Glioma

description: A glioma that arises from the tectum mesenchephali.


Monoplegia

description: Paralysis that affects one limb.


Epididymal Squamous Cell Carcinoma

description: An exceedingly rare carcinoma with squamous differentiation arising from the epididymis.


Adipsic Diabetes Insipidus

description: Diabetes insipidus complicated by a deficient or absent thirst response to hyperosmolality, usually as a result of hypothalamic damage or dysfunction.


name: WNT-Activated Deep Penetrating/Plexiform Melanocytoma (Nevus)

description: A benign melanocytic neoplasm composed of spindle and/or epithelioid melanocytes and melanophages. It is caused by the combined activation of the WNT signaling and MAP-kinase pathways. It occurs in the head and neck region, trunk, extremities, and conjunctiva. It presents with well-circumscribed, darkly pigmented papules. The neoplastic melanocytes form wedge-shaped, fascicular, or plexiform patterns. Lesions with a wedge-shaped pattern extend into the deep reticular dermis. In plexiform spindle cell lesions, the neoplastic melanocytes proliferate in the upper dermis. A junctional component is present in the majority of cases. It rarely progresses to melanoma.


Recurrent Schwannoma

description: The reemergence of schwannoma after a period of remission.


Infant Acute Biphenotypic Leukemia

description: An acute biphenotypic leukemia that occurs in infancy.


name: Stage IV Gastric Neuroendocrine Tumor AJCC v8

description: Stage IV includes: (T1, N0, N1, M1); (T2, N0, N1, M1); (T3, N0, N1, M1); (T4, N0, N1, M1). T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. T2: Tumor invading the muscularis propria or is greater than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Non-IgM Monoclonal Gammopathy of Undetermined Significance

description: Monoclonal gammopathy of undetermined significance defined by the presence in the serum of an IgG, IgA, or (rarely) IgD paraprotein at a concentration of less than 30g/L; clonal bone marrow plasma cells less than 10%; and absence of end-organ damage such as hypercalcemia, renal insufficiency, anemia, bone marrow lesions, and amyloidosis attributable to the plasma cell proliferative disorder. The risk of progression to plasma cell myeloma, light-chain amyloidosis, or a related disorder is 1% per year. (WHO 2017)


name: Metastatic Endometrial Mixed Cell Adenocarcinoma

description: Endometrial mixed cell adenocarcinoma that has spread from its original site of growth to another anatomic site.


Meningeal Lymphoma

description: Involvement of the meninges by Hodgkin or non-Hodgkin lymphoma.


Xerostomia caused by ionizing radiation

description: Dryness of the oral mucosa secondary to radiation therapy.


name: Recurrent Acute Myeloid Leukemia with KMT2A Rearrangement

description: The reemergence of acute myeloid leukemia with KMT2A rearrangement after a period of remission.


Urinary System Paraganglioma

description: An extra-adrenal paraganglioma that arises from the urinary system.


Surgical Wound Infection

description: An infection that occurs at a surgical site within 30 days after an operation.


Refractory Lymphoproliferative Disorder

description: Lymphoproliferative disorder that is resistant to treatment.


Penile Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the penis. Representative examples include phimosis, balanitis, and hypospadias.


name: large cell neuroendocrine carcinoma of appendix

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the appendix.  It is characterized by the presence of malignant large cells.


Childhood Bone Neoplasm

description: A bone neoplasm that occurs during childhood.


Stage IVB Uterine Corpus Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, lung, liver, or bone. It excludes metastasis to pelvic or para-aortic lymph nodes, vagina, uterine serosa, or adnexa). (from AJCC 8th Ed.)


Neoplasm of broad ligament

description: A benign, borderline, or malignant neoplasm that affects the broad ligament.


name: Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive

description: Chronic myeloid leukemia, BCR-ABL1 positive that is resistant to treatment.


Stage I Cervical Cancer FIGO 2009

description: The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded). (FIGO 2009)


Refractory Gliosarcoma

description: A gliosarcoma that is resistant to treatment.


Spinal vascular disorder

description: A disorder that is caused by pathologic changes in the spinal vasculature.


Kidney Neuroendocrine Tumor

description: A well-differentiated neuroendocrine neoplasm arising from the kidney. It is characterized by the presence of uniform cells with stippled chromatin and inconspicuous nucleoli. Mitotic activity is low and tumor necrosis is absent.


Esophageal Schwannoma

description: A slowly growing, benign, usually encapsulated neoplasm arising from the esophagus.  Morphologically, it is composed of neoplastic differentiated Schwann cells.


name: Stage III Gestational Trophoblastic Tumor AJCC v7

description: Stage III includes: (Any T, M1a, Risk factors: unknown); IIIA (Any T, M1a, Risk factors: low risk); IIIB (Any T, M1a, Risk factors: high risk).  M1a: Lung metastasis.  (AJCC 7th ed.)


name: Diffuse Hyperplastic Perilobar Nephroblastomatosis


Posthemorrhagic hydrocephalus

description: An abnormal accumulation of cerebrospinal fluid within the ventricles of the brain that occurs as a later sequela of an intraventricular or subarachnoid hemorrhage.


Delusional disorder, persecutory type

description: A subtype of delusional disorder characterized by the central delusional theme that the individual is being malevolently treated (for example, maligned, harassed, conspired against, poisoned or drugged) by another person or group.


Mixed Phenotype Acute Leukemia, B/T

description: A very rare mixed phenotype acute leukemia in which the blasts show clear-cut evidence of both B-cell and T-cell lineage but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation.


Infrequent Neoplasm

description: A neoplasm that is uncommon.


Southern tick-associated rash illness

description: A putative Borrelia infection causing acute manifestations similar to Lyme disease, particularly erythema migrans, following the bite of the lone star tick, Amblyomma americanum.


name: Localized Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Tumor confined to area of origin including abdominal lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Refractory Osteosarcoma

description: Osteosarcoma that does not respond to treatment.


Cervical Mucoepidermoid Carcinoma

description: A rare carcinoma that arises from the cervix. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type.


Soft Tissue Infection

description: A bacterial infectious process affecting the soft tissues. A severe form caused by anaerobic or aerobic bacteria is associated with soft tissues necrosis and affects the subcutaneous adipose tissue, muscles, fascia, and the skin.


name: Gastric Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of a gastric neuroendocrine tumor according to the American Joint Committee on Cancer, 8th edition. This staging system applies to gastric "carcinoid" tumors (NET G1 and G2, and rare well-differentiated G3). Gastric high-grade neuroendocrine carcinoma and gastric mixed adenoneuroendocrine carcinoma are not included in this staging system. (from AJCC 8th Ed.)


Refractory AL Amyloidosis

description: AL amyloidosis that does not respond to treatment.


Pure Cutaneous Mastocytosis

description: Mastocytosis that manifests with pure cutaneous involvement.


name: Gastrointestinal Tract Acute Graft Versus Host Disease

description: Acute graft versus host disease occurring in the gastrointestinal tract.


name: Stage III Ampulla of Vater Cancer AJCC v8

description: Stage III includes: IIIA: (T1a, N1, M0); (T1b, N1, M0); (T2, N1, M0); (T3a, N1, M0); (T3b, N1, M0); IIIB: (T4, Any N, M0); (Any T, N2, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. T4: Tumor involving the celiac axis, superior mesenteric artery, and/or common hepatic artery, irrespective of size. N1: Metastasis to one to three regional lymph nodes. N2: Metastasis to four or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Hodgkin's disease lymphocyte predominance type stage III

description: Stage III adult Hodgkin disease means the involvement of lymph node regions on both sides of the diaphragm (III), which may also be accompanied by localized involvement of an associated extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or by involvement of both (IIIE + S). Stage III disease may be subdivided by anatomic distribution of abdominal involvement or by extent of splenic involvement. Stage III(1) indicates involvement that is limited to the upper abdomen above the renal vein. Stage III(2) indicates involvement of pelvic and/or para-aortic nodes. Five or more visible splenic nodules on a cut section constitutes extensive splenic involvement. Zero to four nodules is classified as minimal splenic disease. (from PDQ)


Zoonoses

description: Infection by an etiologic agent that can be passed between animals and humans.


Renal Pelvis and Ureter Carcinoma

description: Carcinoma that affects the renal pelvis and ureter.


Bacterial pericarditis

description: Pericarditis that is caused by an infection with a bacterial agent.


Paratesticular malignant neoplasm

description: A primary or metastatic malignant neoplasm that affects the paratesticular structures.


Resectable Malignant Neoplasm

description: Malignant neoplasm that is amenable to surgical resection.


Breast Nevus

description: A benign melanocytic nevus that arises from the breast skin.


Acute Myeloid Leukemia with NPM1-MLF1

description: Acute myeloid leukemia associated with NPM1-MLF1 gene fusion.


Adenocarcinoma in adenomatous polyp

description: A non-invasive or invasive adenocarcinoma arising from the neoplastic glandular cells in an adenomatous polyp.


name: Locally Advanced Bladder Squamous Cell Carcinoma

description: Bladder squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Congenital facial nerve palsy

description: Partial or complete paralysis of the facial muscles of one side of an individual's face that is present at birth. It is caused by damage to the seventh cranial nerve.


Low Grade Sarcoma

description: A sarcoma with the morphologic features of a low-grade tumor and presence of cellular differentiation.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Tier 1, Children's Oncology Group (COG) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the tier 1 Toronto childhood cancer staging guidelines v2, Children's Oncology Group (COG) protocol.


name: Vulvar Small Cell Neuroendocrine Carcinoma

description: A rare small cell neuroendocrine carcinoma that arises from the vulva.


Peritoneal Infection

description: An infectious process affecting the peritoneum.


Stage IVA Vaginal Cancer AJCC v6 and v7

description: Stage IVA includes: T4, Any N, M0. T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4).  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Advanced Non-Cutaneous Melanoma

description: Non-cutaneous melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Work shift change (disorder)

description: A subtype of circadian rhythm sleep disorder in which the individual exhibits a normal endogenous pattern of sleep and wakefulness, but this pattern comes into conflict with the desired pattern of sleep and wakefulness required by shift work.


Stage IIB Cervical Cancer FIGO 2018

description: Cervical carcinoma with parametrial involvement but not up to the pelvic wall. (FIGO 2018)


Parapsoriasis en Plaques

description: A variant of parapsoriasis in which the plaques are large.


Unresectable Cutaneous Melanoma

description: A skin melanoma that is not amenable to surgical resection.


Cutaneous Perineurioma

description: A rare perineurioma arising from the skin.


Late Prosthetic Valve Endocarditis

description: Prosthetic valve endocarditis that occurs several months to years following valve replacement.


name: Recurrent Atypical Chronic Myeloid Leukemia

description: The reemergence of atypical chronic myeloid leukemia after a period of remission.


Radiation damage to artery

description: A damage to arteries caused by radiation therapy.


name: Postoperative Spindle Cell Nodule of the Cervix

description: A rare, benign, non-neoplastic reactive lesion that develops in the cervix at the site of a prior operative procedure. It is composed of spindle cells, small blood vessels, and chronic inflammation.


name: Metastatic Malignant Neoplasm in the Digestive System

description: A malignant neoplasm that has spread to the digestive system from another anatomic site.


Stage III Cutaneous Melanoma AJCC v7

description: Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Inflamed Juvenile Conjunctival Nevus

description: A compound nevus that arises from the conjunctiva in children and adolescents. It is characterized by the presence of chronic inflammatory features.


Unresectable Myxoid Liposarcoma

description: A myxoid liposarcoma that is not amenable to surgical resection.


name: Disseminated Intravascular Coagulation Related to COVID-19

description: Disseminated intravascular coagulation in a patient with probable or confirmed acute COVID-19.


name: Stage III Adult Diffuse Mixed Cell Lymphoma

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


Appendix Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of appendiceal carcinoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas of the appendix, including high-grade neuroendocrine carcinomas, mixed adenoneuroendocrine carcinomas, and goblet cell carcinoids. Well-differentiated neuroendocrine tumors (carcinoids) are staged according to the classification for neuroendocrine tumors of the appendix. (from AJCC 8th Ed.)


Stage IA Vulvar Carcinoma AJCC v6

description: Stage IA includes: Tia, N0, M0.  T1a: Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension, and with stromal invasion no greater than 1mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Adenocarcinoma of the prostate stage II

description: Stage II includes: IIA (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X); IIB (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  T2c: Tumor involves both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


name: Advanced Malignant Digestive System Neoplasm

description: A malignant digestive system neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Localized Gastric Adenocarcinoma

description: An adenocarcinoma that arises from the stomach and has not spread to other anatomic sites.


name: FIGO Stage III Gestational Trophoblastic Tumor

description: Lesion affects the lungs, with or without known genital structures invasion.


name: Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive

description: A chronic myeloid leukemia, BCR-ABL1 positive occurring during childhood.


Mucosal nodular melanoma

description: Nodular melanoma that arises from a mucosal site.


Stage IIB Cervical Cancer FIGO 2009

description: Cervical carcinoma with parametrial invasion. (FIGO 2009)


name: Stage IVB Gestational Trophoblastic Tumor AJCC v7

description: Stage IVB includes: Any T, M1b, Risk factors: high risk.  M1b: All other distant metastasis.  (AJCC 7th ed.)


ALK-Positive Histiocytosis

description: A rare histiocytic neoplasm associated with ALK gene rearrangement leading to activation of signaling pathways. The neoplastic cells have a mature histiocytic phenotype, and usually have a foamy cytoplasm. It is characterized by frequent neurologic involvement and responds to ALK inhibition treatments.


Astler-Coller B3 Colon Carcinoma

description: Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


name: FIGO Stage IIA Gestational Trophoblastic Tumor


Liquid Tumor

description: A malignant tumor that originates from myeloid or lymphoid cells i.e., leukemias and lymphomas.


Benign fibrohistiocytic neoplasm

description: A mesenchymal neoplasm composed of fibrohistiocytic cells, spindle fibroblastic cells, and histiocytes, in a storiform pattern. There is no evidence of atypical or malignant cytological and architectural features, invasive features, or metastases.


name: Bone Malignant Peripheral Nerve Sheath Tumor

description: An exceedingly rare malignant peripheral nerve sheath tumor that arises from the bone.


name: Lung Adenocarcinoma with Mixed Bronchioloalveolar and Invasive Components

description: A lung adenocarcinoma consisting of a bronchioloalveolar component and an invasive adenocarcinomatous component.


Stage II Bone Cancer AJCC v7

description: Stage II includes: IIA (T1, N0, M0, G3, G4); IIB (T2, N0, M0, G3, G4).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Sarcoma of pelvis

description: Sarcoma involving the organs and structures of the pelvis.


Refractory Anaplastic Astrocytoma

description: An anaplastic astrocytoma that is resistant to treatment.


name: Old Burn Scar-Related Skin Squamous Cell Carcinoma

description: A squamous cell carcinoma of the skin that arises from burn scars. It usually manifests between 20 and 40 years after the original burn.


name: Cervical Invasive Stratified Mucinous Adenocarcinoma

description: A rare, distinct form of invasive cervical mucinous adenocarcinoma associated with human papillomavirus infection. It is characterized by the presence of stratiﬁed, immature epithelial cells containing varying quantities of intracytoplasmic mucin.


Stage IVB Appendix Carcinoma AJCC v7

description: Stage IVB includes: (Any T, N0, M1a, G2, G3); (Any T, N1, M1a, Any G); (Any T, N2, M1a, Any G).  N0: No regional lymph node metastasis.  N1: Metastasis in 1-3 regional lymph nodes.  N2: Metastasis in four or more regional lymph nodes.  M1a: Intraperitoneal metastasis beyond the right lower quadrant, including pseudomyxoma peritonei.  G2: Moderately differentiated tumor. G3: Poorly differentiated tumor.  (AJCC 7th ed.)


Neoplasm of uncertain behavior

description: A neoplasm displaying morphologic, phenotypic, or genotypic characteristics that are clearly not benign but do not permit the establishment of a definitive diagnosis of malignancy.  Such neoplasms may or may not eventually have a more aggressive clinical course.  Representative examples include lymphoproliferations of uncertain malignant potential (e.g., lymphomatoid granulomatosis and lymphomatoid papulosis), borderline ovarian epithelial neoplasms (e.g., borderline ovarian endometrioid tumor and borderline ovarian mucinous tumor), borderline exocrine pancreatic neoplasm (e.g., pancreatic borderline intraductal papillary-mucinous neoplasm), and primary borderline peritoneal epithelial neoplasm.


Hernia, Diaphragmatic, Traumatic

description: The protrusion of abdominal cavity contents into the thoracic cavity via a hole in the diaphragm, which was acquired via a traumatic etiology.


Unresectable Urothelial Carcinoma

description: Urothelial carcinoma that is not amenable to surgical resection.


name: Recurrent Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: The reemergence of undifferentiated high grade pleomorphic sarcoma of bone in adulthood after a period of remission.


Metastatic Sarcoma in the Peritoneum

description: A sarcoma that has spread to the peritoneum from an adjacent or distal anatomic site.


Refractory Pancreatobiliary Carcinoma

description: Pancreatobiliary carcinoma that is resistant to treatment.


Acquired phimosis

description: Phimosis that develops in an uncircumcised male with a previously loose foreskin.


name: Platinum-Resistant Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that progresses between one and six months of completing platinum therapy.


Recurrent Langerhans Cell Histiocytosis

description: The reemergence of Langerhans cell histiocytosis after a period of remission.


Disorder of ejaculation

description: A disorder referring to problems related to ejaculation. This category includes premature, delayed, retrograde, and painful ejaculation.


Undifferentiated schizophrenia

description: A subtype of schizophrenia in which the individual exhibits the characteristic symptoms of schizophrenia but the overall picture is not one of catatonic type, paranoid type, or disorganized type schizophrenia.


Stent thrombosis

description: The formation of a blood clot of a vessel or heart chamber after and due to the placement of a stent.


name: Stage IIB Nasopharyngeal Keratinizing Squamous Cell Carcinoma


Hairy Polyp

description: A benign polypoid lesion that usually arises from the nasopharynx. It may also occur in the oropharynx, palate, tonsil, tongue, lip, and middle ear. It usually affects neonates and older infants and is composed of ectoderm and mesoderm.


Chronic Bacterial Prostatitis

description: A chronic infection of the prostate gland caused by bacteria.  It is manifested with recurring urinary tract infections.  The culture of the prostatic fluid, semen, or post-massage urine specimen reveals the presence of bacteria.


Stage I Cervical Cancer AJCC v9

description: Stage I includes: T1, N0, M0. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


MAC lymphadenitis

description: Lymph node infection by Mycobacterium avium or Mycobacterium intracellulare. It most often affects children and usually presents with cervical lymph node enlargement. It generally follows a benign clinical course.


Malignant fibrohistiocytic neoplasm

description: A fibrohistiocytic neoplasm that metastasizes to other anatomic sites.


Oligometastatic Prostate Carcinoma

description: Prostate carcinoma that has metastasized to a limited number of sites.


Mixed Morphea

description: The presence of more than one variant of morphea in a single patient.


Stage III Vaginal Cancer AJCC v6 and v7

description: Stage III includes: (T1-3, N1, M0) and (T3, N0, M0). T1: Tumor confined to vagina.  T2: Tumor invades paravaginal tissues but not to pelvic wall.  T3: Tumor extends to pelvic wall.  N0: No regional lymph node metastasis.  N1: Pelvic or inguinal lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: FIGO Grade 1 Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma exhibiting 5% or less solid non-glandular, non-squamous growth.


Psammocarcinoma

description: An extremely rare variant of serous carcinoma arising from the ovary or peritoneum. It is characterized by extensive formation of psammoma bodies, low-grade cytological features, and invasion of surrounding structures.


Refractory Adenoid Cystic Carcinoma

description: Adenoid cystic carcinoma that is resistant to treatment.


Recurrent Skin Carcinoma

description: A carcinoma of the skin that has recurred after a period of remission.


name: Locally Advanced Malignant Digestive System Neoplasm

description: A malignant digestive system neoplasm that has spread to nearby tissues or lymph nodes.


name: Stage III Esophageal Adenocarcinoma AJCC v7

description: Stage III includes: IIIA (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G); IIIB (T3, N2, M0, Any G); IIIC (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: High-Grade Biliary Intraepithelial Neoplasia

description: Biliary intraepithelial neoplasia characterized by the presence of high grade epithelial dysplasia.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 1

description: Dyskeratosis congenita caused by autosomal dominant mutation(s) in the TERC gene, encoding telomerase RNA component.


Stage IVA Bone Sarcoma AJCC v7

description: Stage IVA includes: Any T, N0, M1a, Any G.  N0: No regional lymph node metastasis.  M1a: Distant metastasis to lung. (AJCC 7th ed.)


Metastatic Neoplasm to the Gallbladder

description: A malignant neoplasm that has spread to the gallbladder from another anatomic site.  Representative examples include metastatic melanoma, and metastatic carcinomas from the breast and the stomach.


name: Appendix Low Grade Intraepithelial Neoplasia

description: A precancerous intraepithelial neoplastic lesion that affects the appendix.  It is characterized by the presence of mild dysplasia and mild architectural alterations of the mucosal epithelium.  There is no evidence of invasion.


name: Neuroendocrine Carcinoma, Excluding Head and Neck

description: A rare aggressive neuroendocrine carcinoma that arises from the skin and most often affects older individuals. It is usually located in the head, neck, and extremities. The tumor is composed of small round cells with scanty cytoplasm. Merkel cell polyomavirus is implicated in the majority of cases.


Thrombosis of blood vessel

description: The formation of a blood clot in the lumen of a vessel; causes include coagulation disorders, and vascular endothelial injury.


Trichoadenoma

description: A rare, benign, slowly growing tumor of the hair follicle occurring usually in the face or buttocks.  Morphologically, it is a well-defined dermal tumor that contains numerous cysts and epithelial islands. The cysts are lined by infundibulum-like squamous epithelial cells.


name: Pathologic Stage III Cutaneous Melanoma AJCC v8

description: Stage III includes: IIIA: (T1a/b-T2a, N1a or N2a, M0); IIIB: (T0, N1b, N1c, M0); (T1a/b-T2a, N1b/c or N2b, M0); (T2b/T3a, N1a-N2b, M0); IIIC: (T0, N2b, N2c, N3b or N3c); (T1a-T3a, N2c or N3a/b/c, M0); (T3b/T4a, Any N greater than or equal to N1, M0); (T4b, N1a-N2c, M0); IIID: (T4b, N3a/b/c, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N2c: One clinically occult nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Stage I Anal Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor 2 cm or smaller. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


description: A hepatocellular adenoma caused by inactivating mutations of the HNF1A gene.  It is characterized by the presence of lobulated contours, steatosis, and absence of inflammation or nuclear atypia.


name: Simple Endometrial Hyperplasia with Atypia

description: A proliferation of endometrial cells resulting in glandular enlargement and budding without changes in the basic structure of the endometrium. Epithelial atypia is present.


Stage II Cervical Cancer AJCC v7

description: Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0); IIB (T2b, N0, M0); T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Childhood Malignant Central Nervous System Neoplasm

description: A primary or metastatic malignant neoplasm that affects the central nervous system and occurs during childhood.


Juvenile systemic scleroderma

description: Systemic sclerosis that is diagnosed in children. Juvenile systemic sclerosis is more likely to be of the overlap variant and presents with musculoskeletal involvement.


name: Precursor T-lymphoblastic lymphoma/leukemia stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, or nodular involvement of the lungs(s).


name: Clinical Stage III Retinoblastoma AJCC v8

description: Stage III includes: (cT4b, cN0, cM0, Any H); (Any cT, cN1, cM0, Any H). cT4b: Extraocular tumor clinically evident with proptosis and/or an orbital mass. cN0: No regional lymph node involvement. cN1: Evidence of preauricular, submandibular, and cervical lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Metastatic Melanoma in the Viscera

description: A melanoma that has spread to visceral organs from a cutaneous or extracutaneous primary site.


Stage II Testicular Cancer AJCC v8

description: Stage II includes: Any pT/TX, N1-3, M0, SX. TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. SX: Marker studies not available or not performed. (AJCC 8th ed.)


Congenital ankyloblepharon

description: A congenital abnormality in which the margins of the upper and lower eyelids are fused together by bands of tissue.


Spiradenocylindroma

description: A benign adnexal neoplasm with histological features of both spiradenoma and cylindroma in a single nodular lesion.


Midgut Neuroendocrine Tumor G2

description: A neuroendocrine tumor grade 2 that arises from the jejunum, ileum, proximal colon, or appendix.


Cutaneous Fistula

description: An abnormal communication between the skin and another organ or cavity.


name: Metastatic Genitourinary System Carcinoma

description: A carcinoma that arises from the genitourinary system and has metastasized to other anatomic sites.


name: Unresectable Anal Squamous Cell Carcinoma

description: Anal squamous cell carcinoma that is not amenable to surgical resection.


Malignant cylindroma of skin

description: A carcinoma that arises in a cylindroma.


name: Unresectable Pancreatic Neuroendocrine Neoplasm

description: A pancreatic neuroendocrine neoplasm that is not amenable to surgical resection.


Non-Neoplastic Hair Disorder

description: A non-neoplastic disorder that affects the hair. Representative examples may include alopecia, male pattern baldness, hirsutism, and hair shaft disorders.


name: High Grade Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting more than 50% solid non-glandular, non-squamous growth.


name: Acute Myocardial Injury Related to Acute COVID-19

description: Acute myocardial injury in an individual with probable or confirmed COVID-19 infection and no alternative explanation for acute myocardial injury.


name: Lugano Classification Stage IE Adult Hodgkin Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


name: Acute myeloid leukemia and myelodysplastic syndrome related to alkylating agent

description: Acute myeloid leukemias and myelodysplastic syndromes arising as a result of the mutagenic effect of alkylating agents that are used for the treatment of malignant tumors. Patients usually develop a myelodysplastic syndrome which may evolve to a higher grade myelodysplastic syndrome or acute myeloid leukemia. A minority of patients present with an acute myeloid leukemia. Clonal cytogenetic abnormalities are frequently present and usually are unbalanced translocations or deletions of chromosomes 5 and 7. Patients with acute myeloid leukemia usually do not respond to treatment and have an unfavorable clinical outcome.


Seminal Vesicle Squamous Cell Carcinoma

description: An extremely rare squamous cell carcinoma that arises from the seminal vesicle. Glandular formation and mucin secretion are absent.


name: Childhood Diffuse Astrocytoma, MYB-Altered

description: A rare diffuse astrocytoma, MYB-altered that occurs during childhood.


Infection by human herpesvirus 6

description: An infection that is caused by human herpesvirus-6.


name: Intermediate Grade Lung Neuroendocrine Neoplasm

description: An intermediate grade malignant neoplasm with neuroendocrine differentiation that arises from the lung.  This category includes atypical carcinoid tumor.


Disorder of AMH Receptor

description: A defect in the Anti-Muellerian hormone receptor.


name: Childhood L2 Acute Lymphoblastic Leukemia

description: L2 acute lymphoblastic leukemia that occurs during childhood.


Sinonasal Chondromesenchymal Hamartoma

description: A benign, locally destructive, sinonasal tumor-like growth containing mixed mesenchymal elements. (WHO 2017)


name: Mitochondrial Hydroxyacyl-Coenzyme A Dehydrogenase Hyperinsulinism

description: Hyperinsulinism due to inactivating mutation(s) in the gene HADH, encoding mitochondrial (short-chain) hydroxyacyl-coenzyme A dehydrogenase, resulting in loss of inhibition of glutamate dehydrogenase (GDH). This condition is also characterized by protein-induced hypoglycemia, but in contrast to GLUD1-associated hyperinsulinism, hyperammonemia is absent.


name: Human Papillomavirus-Related Cervical Squamous Cell Carcinoma

description: A cervical squamous cell carcinoma associated with human papillomavirus infection.


Circumferential Endothelial Hyperplasia

description: Intraluminal hyperplasia of endothelial cells, encircling the entire lumen.


name: Refractory Pancreatic Ductal Adenocarcinoma

description: Pancreatic ductal adenocarcinoma that is resistant to treatment.