name: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Canis familiaris)


name: Sequestration of tBID by BCL-2 (Canis familiaris)

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Canis familiaris)


name: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Bos taurus)

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: Sequestration of tBID by BCL-2 (Bos taurus)


name: BCL2 binds BCL2 antagonists (Bos taurus)


name: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Bos taurus)


name: BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Bos taurus)


name: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Sus scrofa)


name: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Sus scrofa)


name: BCL2 binds BCL2 antagonists (Sus scrofa)


name: BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Sus scrofa)


name: Sequestration of tBID by BCL-2 (Sus scrofa)


name: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Danio rerio)


name: BCL2 binds BCL2 antagonists (Danio rerio)


name: Sequestration of tBID by BCL-2 (Danio rerio)


name: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Danio rerio)


name: BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Danio rerio)


name: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Xenopus tropicalis)


name: BCL2 binds BCL2 antagonists (Xenopus tropicalis)


name: BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Xenopus tropicalis)


name: Sequestration of tBID by BCL-2 (Xenopus tropicalis)


name: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Gallus gallus)


name: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Gallus gallus)


name: BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Gallus gallus)


name: BCL2 binds BCL2 antagonists (Gallus gallus)


name: Sequestration of tBID by BCL-2 (Gallus gallus)


name: BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Caenorhabditis elegans)


name: BCL2 binds BCL2 antagonists (Caenorhabditis elegans)


name: Activation and oligomerization of BAK protein (Homo sapiens)


name: Oligomerization  of BAK at the mitochondrial membrane (Homo sapiens)


name: tBID activates BAK protein (Homo sapiens)


name: tBID binds to inactive BAK protein (Homo sapiens)


name: Activation and oligomerization of BAK protein (Mus musculus)


name: tBID activates BAK protein (Mus musculus)


name: tBID binds to inactive BAK protein (Mus musculus)


name: Oligomerization  of BAK at the mitochondrial membrane (Mus musculus)


name: Activation and oligomerization of BAK protein (Rattus norvegicus)


name: tBID binds to inactive BAK protein (Rattus norvegicus)


name: tBID activates BAK protein (Rattus norvegicus)


name: Oligomerization  of BAK at the mitochondrial membrane (Rattus norvegicus)


name: Activation and oligomerization of BAK protein (Canis familiaris)


name: Oligomerization  of BAK at the mitochondrial membrane (Canis familiaris)


name: tBID binds to inactive BAK protein (Canis familiaris)


name: tBID activates BAK protein (Canis familiaris)


name: Activation and oligomerization of BAK protein (Bos taurus)


name: tBID binds to inactive BAK protein (Bos taurus)


name: Oligomerization  of BAK at the mitochondrial membrane (Bos taurus)


name: Activation and oligomerization of BAK protein (Sus scrofa)


name: Oligomerization  of BAK at the mitochondrial membrane (Sus scrofa)


name: tBID binds to inactive BAK protein (Sus scrofa)


name: Activation and oligomerization of BAK protein (Gallus gallus)


name: tBID activates BAK protein (Gallus gallus)


name: tBID binds to inactive BAK protein (Gallus gallus)


name: Oligomerization  of BAK at the mitochondrial membrane (Gallus gallus)


name: Apoptotic factor-mediated response (Homo sapiens)


name: C1QBP promotes translocation of p14ARF to the mitochondrial matrix (Homo sapiens)


name: Release of apoptotic factors from the mitochondria (Homo sapiens)


name: Release of Cytochrome c from mitochondria (Homo sapiens)


name: Release of SEPT4 from mitochondria (Homo sapiens)


name: Release of SMAC (DIABLO) from mitochondria (Homo sapiens)


name: SMAC (DIABLO) forms dimer (Homo sapiens)


name: Release of apoptotic factors from the mitochondria (Mus musculus)


name: SMAC (DIABLO) forms dimer (Mus musculus)


name: Release of SMAC (DIABLO) from mitochondria (Mus musculus)


name: Release of Cytochrome c from mitochondria (Mus musculus)


name: Release of SEPT4 from mitochondria (Mus musculus)


name: Release of apoptotic factors from the mitochondria (Rattus norvegicus)


name: Release of SEPT4 from mitochondria (Rattus norvegicus)


name: SMAC (DIABLO) forms dimer (Rattus norvegicus)


name: Release of Cytochrome c from mitochondria (Rattus norvegicus)


name: Release of SMAC (DIABLO) from mitochondria (Rattus norvegicus)


name: Release of apoptotic factors from the mitochondria (Canis familiaris)


name: Release of SMAC (DIABLO) from mitochondria (Canis familiaris)


name: SMAC (DIABLO) forms dimer (Canis familiaris)


name: Release of SEPT4 from mitochondria (Canis familiaris)


name: Release of Cytochrome c from mitochondria (Canis familiaris)


name: Release of apoptotic factors from the mitochondria (Bos taurus)


name: Release of SEPT4 from mitochondria (Bos taurus)


name: Release of SMAC (DIABLO) from mitochondria (Bos taurus)


name: Release of Cytochrome c from mitochondria (Bos taurus)


name: Release of apoptotic factors from the mitochondria (Sus scrofa)


name: Release of Cytochrome c from mitochondria (Sus scrofa)


name: Release of SEPT4 from mitochondria (Sus scrofa)


name: Release of SMAC (DIABLO) from mitochondria (Sus scrofa)


name: Release of apoptotic factors from the mitochondria (Danio rerio)


name: Release of Cytochrome c from mitochondria (Danio rerio)


name: Release of SMAC (DIABLO) from mitochondria (Danio rerio)


name: Release of SEPT4 from mitochondria (Danio rerio)


name: Release of apoptotic factors from the mitochondria (Xenopus tropicalis)


name: Release of Cytochrome c from mitochondria (Xenopus tropicalis)


name: SMAC (DIABLO) forms dimer (Xenopus tropicalis)


name: Release of SMAC (DIABLO) from mitochondria (Xenopus tropicalis)


name: Release of apoptotic factors from the mitochondria (Gallus gallus)


name: SMAC (DIABLO) forms dimer (Gallus gallus)


name: Release of Cytochrome c from mitochondria (Gallus gallus)


name: Release of SMAC (DIABLO) from mitochondria (Gallus gallus)


name: Release of SEPT4 from mitochondria (Gallus gallus)


name: Release of apoptotic factors from the mitochondria (Drosophila melanogaster)


name: Release of Cytochrome c from mitochondria (Drosophila melanogaster)


name: Release of SEPT4 from mitochondria (Drosophila melanogaster)


name: Release of apoptotic factors from the mitochondria (Caenorhabditis elegans)


name: Release of Cytochrome c from mitochondria (Caenorhabditis elegans)


name: Release of apoptotic factors from the mitochondria (Dictyostelium discoideum)


name: Release of Cytochrome c from mitochondria (Dictyostelium discoideum)


name: Release of apoptotic factors from the mitochondria (Schizosaccharomyces pombe)


name: Release of SEPT4 from mitochondria (Schizosaccharomyces pombe)


name: Release of Cytochrome c from mitochondria (Schizosaccharomyces pombe)


name: Release of apoptotic factors from the mitochondria (Saccharomyces cerevisiae)


name: Release of Cytochrome c from mitochondria (Saccharomyces cerevisiae)


name: Release of SEPT4 from mitochondria (Saccharomyces cerevisiae)


name: Release of apoptotic factors from the mitochondria (Plasmodium falciparum)


name: Release of Cytochrome c from mitochondria (Plasmodium falciparum)


name: Activation of caspases through apoptosome-mediated cleavage (Homo sapiens)


name: Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)


name: Cleavage of Procaspase-7 by the apoptosome (Homo sapiens)


name: Cleavage of Procaspase‑9 to caspase‑9 (Homo sapiens)


name: CYCS:APAF1 binds procaspase-9 (Homo sapiens)


name: Regulation of the apoptosome activity (Homo sapiens)


name: CASP9 is phosphorylated at T412 (Homo sapiens)


name: Regulation of the apoptosome activity (Mus musculus)


name: CASP9 is phosphorylated at T412 (Mus musculus)


name: Regulation of the apoptosome activity (Rattus norvegicus)


name: APAF1:CYCS binds APIP (Rattus norvegicus)


name: CASP9 is phosphorylated at T412 (Rattus norvegicus)


name: Regulation of the apoptosome activity (Canis familiaris)


name: CARD8 binds CASP9(1-416) (Canis familiaris)


name: APAF1:CYCS binds APIP (Canis familiaris)


name: CASP9 is phosphorylated at T412 (Canis familiaris)


name: Regulation of the apoptosome activity (Bos taurus)


name: CASP9 is phosphorylated at T412 (Bos taurus)


name: Regulation of the apoptosome activity (Sus scrofa)


name: CASP9 is phosphorylated at T412 (Sus scrofa)


name: Regulation of the apoptosome activity (Danio rerio)


name: CASP9 is phosphorylated at T412 (Danio rerio)


name: Regulation of the apoptosome activity (Xenopus tropicalis)


name: APAF1:CYCS binds APIP (Xenopus tropicalis)


name: CASP9 is phosphorylated at T412 (Xenopus tropicalis)


name: Regulation of the apoptosome activity (Gallus gallus)


name: CARD8 binds CASP9(1-416) (Gallus gallus)


name: CASP9 is phosphorylated at T412 (Gallus gallus)


name: Regulation of the apoptosome activity (Drosophila melanogaster)


name: APAF1 binds AVEN (Drosophila melanogaster)


name: XIAP binds CASP9 (Drosophila melanogaster)


name: CASP9 is phosphorylated at T412 (Drosophila melanogaster)


name: APAF1:CYCS binds APIP (Drosophila melanogaster)


name: Cleavage of Procaspase‑9 to caspase‑9 (Mus musculus)


name: CYCS:APAF1 binds procaspase-9 (Mus musculus)


name: Formation of apoptosome (Rattus norvegicus)


name: Cleavage of Procaspase‑9 to caspase‑9 (Rattus norvegicus)


name: Procaspase 9 forms dimer (Rattus norvegicus)


name: CYCS:APAF1 binds procaspase-9 (Rattus norvegicus)


name: Formation of apoptosome (Canis familiaris)


name: Cleavage of Procaspase‑9 to caspase‑9 (Canis familiaris)


name: Procaspase 9 forms dimer (Canis familiaris)


name: CYCS:APAF1 binds procaspase-9 (Canis familiaris)


name: Cleavage of Procaspase‑9 to caspase‑9 (Bos taurus)


name: CYCS:APAF1 binds procaspase-9 (Bos taurus)


name: CYCS:APAF1 binds procaspase-9 (Sus scrofa)


name: Cleavage of Procaspase‑9 to caspase‑9 (Sus scrofa)


name: CYCS:APAF1 binds procaspase-9 (Danio rerio)


name: Cleavage of Procaspase‑9 to caspase‑9 (Danio rerio)


name: Formation of apoptosome (Xenopus tropicalis)


name: Procaspase 9 forms dimer (Xenopus tropicalis)


name: CYCS:APAF1 binds procaspase-9 (Xenopus tropicalis)


name: Cleavage of Procaspase‑9 to caspase‑9 (Xenopus tropicalis)


name: CYCS binds to APAF1 (Xenopus tropicalis)


name: Cleavage of Procaspase‑9 to caspase‑9 (Gallus gallus)


name: CYCS:APAF1 binds procaspase-9 (Gallus gallus)


name: Procaspase 9 forms dimer (Gallus gallus)


name: Formation of apoptosome (Drosophila melanogaster)


name: CYCS binds to APAF1 (Drosophila melanogaster)


name: CYCS:APAF1 binds procaspase-9 (Drosophila melanogaster)


name: Cleavage of Procaspase‑9 to caspase‑9 (Drosophila melanogaster)


name: Procaspase 9 forms dimer (Drosophila melanogaster)


name: Activation of caspases through apoptosome-mediated cleavage (Mus musculus)


name: Cleavage of Procaspase-7 by the apoptosome (Mus musculus)


name: Cleavage of Procaspase-3 by the apoptosome (Mus musculus)


name: Activation of caspases through apoptosome-mediated cleavage (Rattus norvegicus)


name: Cleavage of Procaspase-7 by the apoptosome (Rattus norvegicus)


name: Cleavage of Procaspase-3 by the apoptosome (Rattus norvegicus)


name: Activation of caspases through apoptosome-mediated cleavage (Canis familiaris)


name: Cleavage of Procaspase-7 by the apoptosome (Canis familiaris)


name: Cleavage of Procaspase-3 by the apoptosome (Canis familiaris)


name: Activation of caspases through apoptosome-mediated cleavage (Bos taurus)


name: Cleavage of Procaspase-7 by the apoptosome (Bos taurus)


name: Cleavage of Procaspase-3 by the apoptosome (Bos taurus)


name: Activation of caspases through apoptosome-mediated cleavage (Sus scrofa)


name: Cleavage of Procaspase-7 by the apoptosome (Sus scrofa)


name: Cleavage of Procaspase-3 by the apoptosome (Sus scrofa)


name: Activation of caspases through apoptosome-mediated cleavage (Danio rerio)


name: Cleavage of Procaspase-7 by the apoptosome (Danio rerio)


name: Cleavage of Procaspase-3 by the apoptosome (Danio rerio)


name: Activation of caspases through apoptosome-mediated cleavage (Xenopus tropicalis)


name: Cleavage of Procaspase-7 by the apoptosome (Xenopus tropicalis)


name: Cleavage of Procaspase-3 by the apoptosome (Xenopus tropicalis)


name: Activation of caspases through apoptosome-mediated cleavage (Gallus gallus)


name: Cleavage of Procaspase-7 by the apoptosome (Gallus gallus)


name: Cleavage of Procaspase-3 by the apoptosome (Gallus gallus)


name: Activation of caspases through apoptosome-mediated cleavage (Drosophila melanogaster)


name: Cleavage of Procaspase-3 by the apoptosome (Drosophila melanogaster)


name: SMAC, XIAP-regulated apoptotic response (Homo sapiens)


name: SMAC (DIABLO) binds to IAPs  (Homo sapiens)


name: SMAC binds XIAP within apoptosome (Homo sapiens)


name: SMAC binds XIAP:Caspase-7 (Homo sapiens)


name: SMAC binds XIAP:Caspase-3 (Homo sapiens)


name: SMAC (DIABLO) binds to IAPs  (Mus musculus)


name: SMAC binds XIAP:Caspase-7 (Mus musculus)


name: SMAC (DIABLO) binds to IAPs  (Rattus norvegicus)


name: SMAC (DIABLO) binds XIAP (Rattus norvegicus)


name: SMAC binds XIAP:Caspase-7 (Rattus norvegicus)


name: SMAC (DIABLO) binds to IAPs  (Canis familiaris)


name: SMAC (DIABLO) binds XIAP (Canis familiaris)


name: SMAC binds XIAP:Caspase-7 (Canis familiaris)


name: SMAC (DIABLO) binds to IAPs  (Bos taurus)


name: SMAC (DIABLO) binds to IAPs  (Sus scrofa)


name: SMAC (DIABLO) binds to IAPs  (Danio rerio)


name: SMAC (DIABLO) binds to IAPs  (Xenopus tropicalis)


name: SMAC (DIABLO) binds XIAP (Xenopus tropicalis)


name: SMAC binds XIAP:Caspase-7 (Xenopus tropicalis)


name: SMAC (DIABLO) binds to IAPs  (Gallus gallus)


name: SMAC binds XIAP:Caspase-7 (Gallus gallus)


name: SMAC (DIABLO) binds XIAP (Gallus gallus)


name: SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes  (Homo sapiens)


name: Dissociation of DIABLO:XIAP from the apoptosome complex (Homo sapiens)


name: Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Homo sapiens)


name: Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 (Homo sapiens)


name: SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes  (Mus musculus)


name: Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Mus musculus)


name: SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes  (Rattus norvegicus)


name: Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Rattus norvegicus)


name: SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes  (Canis familiaris)


name: Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Canis familiaris)


name: SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes  (Bos taurus)


name: Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Bos taurus)


name: SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes  (Sus scrofa)


name: Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Sus scrofa)


name: SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes  (Danio rerio)


name: Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Danio rerio)


name: SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes  (Xenopus tropicalis)


name: Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Xenopus tropicalis)


name: SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes  (Gallus gallus)


name: Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Gallus gallus)


name: SMAC, XIAP-regulated apoptotic response (Mus musculus)


name: SMAC, XIAP-regulated apoptotic response (Rattus norvegicus)


name: SMAC, XIAP-regulated apoptotic response (Canis familiaris)


name: SMAC, XIAP-regulated apoptotic response (Bos taurus)


name: SMAC, XIAP-regulated apoptotic response (Sus scrofa)


name: SMAC, XIAP-regulated apoptotic response (Danio rerio)


name: SMAC, XIAP-regulated apoptotic response (Xenopus tropicalis)


name: SMAC, XIAP-regulated apoptotic response (Gallus gallus)


name: SMAC, XIAP-regulated apoptotic response (Drosophila melanogaster)


name: SEPT4 binds XIAP (Drosophila melanogaster)


name: XIAP binds CASP3 (Drosophila melanogaster)


name: SMAC, XIAP-regulated apoptotic response (Schizosaccharomyces pombe)


name: SEPT4 binds XIAP (Schizosaccharomyces pombe)


name: PIP3 activates AKT signaling (Homo sapiens)


name: TORC2 complex phosphorylates SGK1 (Homo sapiens)


name: PIP3 recruits PDPK1 to the membrane (Homo sapiens)


name: RAC1,RAC2,RHOG activate PI3K (Homo sapiens)


name: PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)


name: TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)


name: PDPK1 phosphorylates SGK1 (Homo sapiens)


name: PIP3 recruits AKT to the membrane (Homo sapiens)


name: AKT translocates to the nucleus (Homo sapiens)


name: AKT phosphorylates targets in the nucleus (Homo sapiens)


name: AKT can phosphorylate RSK (Homo sapiens)


name: AKT can phosphorylate NR4A1 (NUR77) (Homo sapiens)


name: AKT phosphorylates FOXO transcription factors (Homo sapiens)


name: AKT phosphorylates targets in the nucleus (Mus musculus)


name: AKT can phosphorylate RSK (Mus musculus)


name: AKT phosphorylates FOXO transcription factors (Mus musculus)


name: AKT can phosphorylate NR4A1 (NUR77) (Mus musculus)


name: AKT phosphorylates targets in the nucleus (Rattus norvegicus)


name: AKT can phosphorylate NR4A1 (NUR77) (Rattus norvegicus)


name: AKT phosphorylates CREB1 (Rattus norvegicus)


name: AKT phosphorylates FOXO transcription factors (Rattus norvegicus)


name: AKT can phosphorylate RSK (Rattus norvegicus)


name: AKT phosphorylates targets in the nucleus (Danio rerio)


name: AKT phosphorylates FOXO transcription factors (Danio rerio)


name: AKT can phosphorylate NR4A1 (NUR77) (Danio rerio)


name: AKT phosphorylates targets in the nucleus (Gallus gallus)


name: AKT can phosphorylate RSK (Gallus gallus)


name: AKT can phosphorylate NR4A1 (NUR77) (Gallus gallus)


name: AKT phosphorylates FOXO transcription factors (Gallus gallus)


name: AKT phosphorylates CREB1 (Gallus gallus)


name: AKT phosphorylates targets in the nucleus (Drosophila melanogaster)


name: AKT can phosphorylate RSK (Drosophila melanogaster)


name: AKT phosphorylates FOXO transcription factors (Drosophila melanogaster)


name: AKT phosphorylates CREB1 (Drosophila melanogaster)


name: AKT can phosphorylate NR4A1 (NUR77) (Drosophila melanogaster)


name: AKT phosphorylates targets in the nucleus (Caenorhabditis elegans)


name: AKT can phosphorylate NR4A1 (NUR77) (Caenorhabditis elegans)


name: AKT can phosphorylate RSK (Caenorhabditis elegans)


name: AKT phosphorylates CREB1 (Caenorhabditis elegans)


name: AKT phosphorylates FOXO transcription factors (Caenorhabditis elegans)


name: AKT phosphorylates targets in the nucleus (Dictyostelium discoideum)


name: AKT can phosphorylate RSK (Dictyostelium discoideum)


name: AKT phosphorylates targets in the nucleus (Schizosaccharomyces pombe)


name: AKT can phosphorylate RSK (Schizosaccharomyces pombe)


name: AKT phosphorylates targets in the nucleus (Saccharomyces cerevisiae)


name: AKT can phosphorylate RSK (Saccharomyces cerevisiae)


name: AKT phosphorylates targets in the cytosol (Homo sapiens)


name: AKT phosphorylates caspase-9 (Homo sapiens)


name: AKT phosphorylates AKT1S1 (PRAS40) (Homo sapiens)


name: AKT phosphorylates TSC2, inhibiting it (Homo sapiens)


name: AKT phosphorylates IKKalpha (Homo sapiens)


name: AKT phosphorylates targets in the cytosol (Mus musculus)


name: AKT phosphorylates TSC2, inhibiting it (Mus musculus)


name: AKT phosphorylates AKT1S1 (PRAS40) (Mus musculus)


name: AKT phosphorylates IKKalpha (Mus musculus)


name: AKT phosphorylates caspase-9 (Mus musculus)


name: AKT phosphorylates targets in the cytosol (Rattus norvegicus)


name: AKT phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)


name: AKT phosphorylates IKKalpha (Rattus norvegicus)


name: AKT phosphorylates caspase-9 (Rattus norvegicus)


name: AKT phosphorylates TSC2, inhibiting it (Rattus norvegicus)


name: AKT phosphorylates MKRN1 (Rattus norvegicus)


name: AKT phosphorylates MDM2 (Rattus norvegicus)


name: AKT phosphorylates targets in the cytosol (Danio rerio)


name: AKT phosphorylates IKKalpha (Danio rerio)


name: AKT phosphorylates caspase-9 (Danio rerio)


name: AKT phosphorylates targets in the cytosol (Gallus gallus)


name: AKT phosphorylates MKRN1 (Gallus gallus)


name: AKT phosphorylates caspase-9 (Gallus gallus)


name: AKT phosphorylates IKKalpha (Gallus gallus)


name: AKT phosphorylates TSC2, inhibiting it (Gallus gallus)


name: AKT phosphorylates targets in the cytosol (Drosophila melanogaster)


name: AKT phosphorylates IKKalpha (Drosophila melanogaster)


name: AKT phosphorylates AKT1S1 (PRAS40) (Drosophila melanogaster)


name: AKT phosphorylates TSC2, inhibiting it (Drosophila melanogaster)


name: AKT phosphorylates MKRN1 (Drosophila melanogaster)


name: AKT phosphorylates caspase-9 (Drosophila melanogaster)


name: AKT phosphorylates targets in the cytosol (Caenorhabditis elegans)


name: AKT phosphorylates caspase-9 (Caenorhabditis elegans)


name: AKT phosphorylates MKRN1 (Caenorhabditis elegans)


name: AKT phosphorylates targets in the cytosol (Dictyostelium discoideum)


name: AKT phosphorylates TSC2, inhibiting it (Dictyostelium discoideum)


name: AKT phosphorylates MKRN1 (Dictyostelium discoideum)


name: AKT phosphorylates targets in the cytosol (Schizosaccharomyces pombe)


name: AKT phosphorylates MKRN1 (Schizosaccharomyces pombe)


name: AKT phosphorylates TSC2, inhibiting it (Schizosaccharomyces pombe)


name: Negative regulation of the PI3K/AKT network (Homo sapiens)


name: PTEN dephosphorylates PIP3 (Homo sapiens)


name: PHLPP dephosphorylates S473 in AKT (Homo sapiens)


name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Homo sapiens)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)


name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)


name: AKT1 dephosphorylation by PP2A-B56-beta,gamma (Homo sapiens)


name: IER3 recruits MAPKs to PP2A-B56-beta,gamma (Homo sapiens)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Mus musculus)


name: PI3K phosphorylates PIP2 to PIP3 (Mus musculus)


name: IER3 recruits MAPKs to PP2A-B56-beta,gamma (Mus musculus)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Mus musculus)


name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Mus musculus)


name: AKT1 dephosphorylation by PP2A-B56-beta,gamma (Mus musculus)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Rattus norvegicus)


name: AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)


name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Rattus norvegicus)


name: PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)


name: MAPKs phosphorylate PP2A (Rattus norvegicus)


name: IER3 recruits MAPKs to PP2A-B56-beta,gamma (Rattus norvegicus)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)


name: IER3 recruits MAPKs to PP2A-B56-beta,gamma (Canis familiaris)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)


name: MAPKs phosphorylate PP2A (Canis familiaris)


name: PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)


name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Canis familiaris)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)


name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Bos taurus)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)


name: IER3 recruits MAPKs to PP2A-B56-beta,gamma (Bos taurus)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)


name: PI3K phosphorylates PIP2 to PIP3 (Bos taurus)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)


name: IER3 recruits MAPKs to PP2A-B56-beta,gamma (Sus scrofa)


name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Sus scrofa)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Sus scrofa)


name: PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Sus scrofa)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)


name: AKT1 dephosphorylation by PP2A-B56-beta,gamma (Danio rerio)


name: PI3K phosphorylates PIP2 to PIP3 (Danio rerio)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)


name: IER3 recruits MAPKs to PP2A-B56-beta,gamma (Danio rerio)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Xenopus tropicalis)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Xenopus tropicalis)


name: PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)


name: PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Gallus gallus)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Gallus gallus)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Drosophila melanogaster)


name: AKT1 dephosphorylation by PP2A-B56-beta,gamma (Drosophila melanogaster)


name: PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)


name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Drosophila melanogaster)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)


name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Caenorhabditis elegans)


name: AKT1 dephosphorylation by PP2A-B56-beta,gamma (Caenorhabditis elegans)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)


name: PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Dictyostelium discoideum)


name: AKT1 dephosphorylation by PP2A-B56-beta,gamma (Dictyostelium discoideum)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Dictyostelium discoideum)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Schizosaccharomyces pombe)


name: AKT1 dephosphorylation by PP2A-B56-beta,gamma (Schizosaccharomyces pombe)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Schizosaccharomyces pombe)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Saccharomyces cerevisiae)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)


name: AKT1 dephosphorylation by PP2A-B56-beta,gamma (Saccharomyces cerevisiae)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Saccharomyces cerevisiae)


name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Plasmodium falciparum)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Plasmodium falciparum)


name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)


name: Negative regulation of the PI3K/AKT network (Mus musculus)


name: PTEN dephosphorylates PIP3 (Mus musculus)


name: PHLPP dephosphorylates S473 in AKT (Mus musculus)


name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Mus musculus)


name: Negative regulation of the PI3K/AKT network (Rattus norvegicus)


name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Rattus norvegicus)


name: PHLPP dephosphorylates S473 in AKT (Rattus norvegicus)


name: PTEN dephosphorylates PIP3 (Rattus norvegicus)


name: Negative regulation of the PI3K/AKT network (Canis familiaris)


name: PTEN dephosphorylates PIP3 (Canis familiaris)


name: Negative regulation of the PI3K/AKT network (Bos taurus)


name: Negative regulation of the PI3K/AKT network (Sus scrofa)


name: Negative regulation of the PI3K/AKT network (Danio rerio)


name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Danio rerio)


name: PTEN dephosphorylates PIP3 (Danio rerio)


name: Negative regulation of the PI3K/AKT network (Xenopus tropicalis)


name: PTEN dephosphorylates PIP3 (Xenopus tropicalis)


name: Negative regulation of the PI3K/AKT network (Gallus gallus)


name: PTEN dephosphorylates PIP3 (Gallus gallus)


name: PHLPP dephosphorylates S473 in AKT (Gallus gallus)


name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Gallus gallus)


name: Negative regulation of the PI3K/AKT network (Drosophila melanogaster)


name: PTEN dephosphorylates PIP3 (Drosophila melanogaster)


name: PHLPP dephosphorylates S473 in AKT (Drosophila melanogaster)


name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Drosophila melanogaster)


name: Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)


name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Caenorhabditis elegans)


name: PTEN dephosphorylates PIP3 (Caenorhabditis elegans)


name: Negative regulation of the PI3K/AKT network (Dictyostelium discoideum)


name: PTEN dephosphorylates PIP3 (Dictyostelium discoideum)


name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Dictyostelium discoideum)


name: Negative regulation of the PI3K/AKT network (Schizosaccharomyces pombe)


name: PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)


name: Negative regulation of the PI3K/AKT network (Saccharomyces cerevisiae)


name: PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)


name: Regulation of PTEN mRNA translation (Homo sapiens)


name: miR-93 microRNA binds PTEN mRNA (Homo sapiens)


name: PTEN mRNA translation is negatively regulated by microRNAs (Homo sapiens)


name: miR-22 microRNA binds PTEN mRNA (Homo sapiens)


name: miR-25 microRNA binds PTEN mRNA (Homo sapiens)


name: miR-19b microRNA binds PTEN mRNA (Homo sapiens)


name: miR-106 microRNAs bind PTEN mRNA (Homo sapiens)


name: miR-17 microRNA binds PTEN mRNA (Homo sapiens)


name: miR-21 nonendonucleolytic RISC binds PTEN mRNA (Homo sapiens)


name: miR-20 microRNAs bind PTEN mRNA (Homo sapiens)


name: miR-205 microRNA binds PTEN mRNA (Homo sapiens)


name: miR-26A microRNAs bind PTEN mRNA (Homo sapiens)


name: miR-214 microRNA binds PTEN mRNA (Homo sapiens)


name: miR-19a microRNA binds PTEN mRNA (Homo sapiens)


name: Competing endogenous RNAs (ceRNAs) regulate PTEN translation (Homo sapiens)


name: miR-17 microRNA binds CNOT6L mRNA (Homo sapiens)


name: miR-17 microRNA binds VAPA mRNA (Homo sapiens)


name: miR-19b microRNA binds CNOT6L mRNA (Homo sapiens)


name: miR-19a microRNA binds VAPA mRNA (Homo sapiens)


name: miR-106 microRNAs bind VAPA mRNA (Homo sapiens)


name: miR-20 microRNAs bind CNOT6L mRNA (Homo sapiens)


name: miR-20 microRNAs bind VAPA mRNA (Homo sapiens)


name: PTENP1 mRNA binds miR-19b RISC (Homo sapiens)


name: miR-106a,(miR106b) microRNA binds CNOT6L mRNA (Homo sapiens)


name: miR-19a microRNA binds CNOT6L mRNA (Homo sapiens)


name: PTENP1 mRNA binds miR-20 RISC (Homo sapiens)


name: Regulation of PTEN localization (Homo sapiens)


name: USP7 deubiquitinates monoubiquitinated PTEN (Homo sapiens)


name: Monoubiquitinated PTEN translocates to the nucleus (Homo sapiens)


name: PTEN undergoes monoubiquitination (Homo sapiens)


name: Deubiquitinated PTEN translocates to the cytosol (Homo sapiens)


name: Regulation of PTEN localization (Mus musculus)


name: PTEN undergoes monoubiquitination (Mus musculus)


name: Monoubiquitinated PTEN translocates to the nucleus (Mus musculus)


name: Deubiquitinated PTEN translocates to the cytosol (Mus musculus)


name: USP7 deubiquitinates monoubiquitinated PTEN (Mus musculus)


name: Regulation of PTEN localization (Rattus norvegicus)


name: Monoubiquitinated PTEN translocates to the nucleus (Rattus norvegicus)


name: Deubiquitinated PTEN translocates to the cytosol (Rattus norvegicus)


name: USP7 deubiquitinates monoubiquitinated PTEN (Rattus norvegicus)


name: PTEN undergoes monoubiquitination (Rattus norvegicus)


name: Regulation of PTEN localization (Canis familiaris)


name: Monoubiquitinated PTEN translocates to the nucleus (Canis familiaris)


name: USP7 deubiquitinates monoubiquitinated PTEN (Canis familiaris)


name: PTEN undergoes monoubiquitination (Canis familiaris)


name: Deubiquitinated PTEN translocates to the cytosol (Canis familiaris)


name: Regulation of PTEN localization (Bos taurus)


name: Deubiquitinated PTEN translocates to the cytosol (Bos taurus)


name: Monoubiquitinated PTEN translocates to the nucleus (Bos taurus)


name: PTEN undergoes monoubiquitination (Bos taurus)


name: USP7 deubiquitinates monoubiquitinated PTEN (Bos taurus)


name: Regulation of PTEN localization (Sus scrofa)


name: Monoubiquitinated PTEN translocates to the nucleus (Sus scrofa)


name: PTEN undergoes monoubiquitination (Sus scrofa)


name: USP7 deubiquitinates monoubiquitinated PTEN (Sus scrofa)


name: Deubiquitinated PTEN translocates to the cytosol (Sus scrofa)


name: Regulation of PTEN localization (Danio rerio)


name: Deubiquitinated PTEN translocates to the cytosol (Danio rerio)


name: PTEN undergoes monoubiquitination (Danio rerio)


name: Monoubiquitinated PTEN translocates to the nucleus (Danio rerio)


name: Regulation of PTEN localization (Xenopus tropicalis)


name: Monoubiquitinated PTEN translocates to the nucleus (Xenopus tropicalis)


name: Deubiquitinated PTEN translocates to the cytosol (Xenopus tropicalis)


name: PTEN undergoes monoubiquitination (Xenopus tropicalis)


name: Regulation of PTEN localization (Gallus gallus)


name: USP7 deubiquitinates monoubiquitinated PTEN (Gallus gallus)


name: Deubiquitinated PTEN translocates to the cytosol (Gallus gallus)


name: PTEN undergoes monoubiquitination (Gallus gallus)


name: Monoubiquitinated PTEN translocates to the nucleus (Gallus gallus)


name: Regulation of PTEN localization (Drosophila melanogaster)


name: PTEN undergoes monoubiquitination (Drosophila melanogaster)


name: Deubiquitinated PTEN translocates to the cytosol (Drosophila melanogaster)


name: USP7 deubiquitinates monoubiquitinated PTEN (Drosophila melanogaster)


name: Monoubiquitinated PTEN translocates to the nucleus (Drosophila melanogaster)


name: Regulation of PTEN localization (Caenorhabditis elegans)


name: Deubiquitinated PTEN translocates to the cytosol (Caenorhabditis elegans)


name: Monoubiquitinated PTEN translocates to the nucleus (Caenorhabditis elegans)


name: USP7 deubiquitinates monoubiquitinated PTEN (Caenorhabditis elegans)


name: Regulation of PTEN localization (Dictyostelium discoideum)


name: USP7 deubiquitinates monoubiquitinated PTEN (Dictyostelium discoideum)


name: Deubiquitinated PTEN translocates to the cytosol (Dictyostelium discoideum)


name: Monoubiquitinated PTEN translocates to the nucleus (Dictyostelium discoideum)


name: Regulation of PTEN localization (Schizosaccharomyces pombe)


name: PTEN undergoes monoubiquitination (Schizosaccharomyces pombe)


name: USP7 deubiquitinates monoubiquitinated PTEN (Schizosaccharomyces pombe)


name: Deubiquitinated PTEN translocates to the cytosol (Schizosaccharomyces pombe)


name: Monoubiquitinated PTEN translocates to the nucleus (Schizosaccharomyces pombe)


name: Regulation of PTEN localization (Saccharomyces cerevisiae)


name: Monoubiquitinated PTEN translocates to the nucleus (Saccharomyces cerevisiae)


name: USP7 deubiquitinates monoubiquitinated PTEN (Saccharomyces cerevisiae)


name: Deubiquitinated PTEN translocates to the cytosol (Saccharomyces cerevisiae)


name: Regulation of PTEN gene transcription (Homo sapiens)


name: PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)


name: MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)


name: MAF1 translocates to the nucleus (Homo sapiens)


name: NR2E1 associated with transcription repressors binds PTEN promoter (Homo sapiens)


name: p-T69,T71-ATF2 binds PTEN gene promoter (Homo sapiens)


name: EGR1 binds the PTEN gene promoter (Homo sapiens)


name: JUN binds the PTEN gene promoter (Homo sapiens)


name: Activated PPARG binds PTEN gene promoter (Homo sapiens)


name: MECOM (EVI1) binds the PTEN gene promoter (Homo sapiens)


name: SALL4 recruits NuRD to PTEN gene (Homo sapiens)


name: MAF1 binds the PTEN gene promoter (Homo sapiens)


name: mTORC1 phosphorylates MAF1 (Homo sapiens)


name: SNAI1,SNAI2 bind the PTEN gene promoter (Homo sapiens)


name: SALL4 binds the PTEN gene promoter (Homo sapiens)


name: TP53 binds the PTEN promoter (Homo sapiens)


name: Regulation of PTEN gene transcription (Mus musculus)


name: MAF1 translocates to the nucleus (Mus musculus)


name: SALL4 recruits NuRD to PTEN gene (Mus musculus)


name: mTORC1 phosphorylates MAF1 (Mus musculus)


name: Regulation of PTEN gene transcription (Rattus norvegicus)


name: mTORC1 phosphorylates MAF1 (Rattus norvegicus)


name: SALL4 recruits NuRD to PTEN gene (Rattus norvegicus)


name: MAF1 translocates to the nucleus (Rattus norvegicus)


name: Regulation of PTEN gene transcription (Canis familiaris)


name: MAF1 translocates to the nucleus (Canis familiaris)


name: mTORC1 phosphorylates MAF1 (Canis familiaris)


name: MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Canis familiaris)


name: SALL4 recruits NuRD to PTEN gene (Canis familiaris)


name: Regulation of PTEN gene transcription (Bos taurus)


name: MAF1 translocates to the nucleus (Bos taurus)


name: SALL4 recruits NuRD to PTEN gene (Bos taurus)


name: Regulation of PTEN gene transcription (Sus scrofa)


name: MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Sus scrofa)


name: SALL4 recruits NuRD to PTEN gene (Sus scrofa)


name: MAF1 translocates to the nucleus (Sus scrofa)


name: Regulation of PTEN gene transcription (Danio rerio)


name: MAF1 translocates to the nucleus (Danio rerio)


name: mTORC1 phosphorylates MAF1 (Danio rerio)


name: Regulation of PTEN gene transcription (Xenopus tropicalis)


name: SALL4 recruits NuRD to PTEN gene (Xenopus tropicalis)


name: Regulation of PTEN gene transcription (Gallus gallus)


name: SALL4 recruits NuRD to PTEN gene (Gallus gallus)


name: MAF1 translocates to the nucleus (Gallus gallus)


name: MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Gallus gallus)


name: mTORC1 phosphorylates MAF1 (Gallus gallus)


name: Regulation of PTEN gene transcription (Drosophila melanogaster)


name: MAF1 translocates to the nucleus (Drosophila melanogaster)


name: mTORC1 phosphorylates MAF1 (Drosophila melanogaster)


name: SALL4 recruits NuRD to PTEN gene (Drosophila melanogaster)


name: MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Drosophila melanogaster)


name: Regulation of PTEN gene transcription (Caenorhabditis elegans)


name: MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Caenorhabditis elegans)


name: MAF1 translocates to the nucleus (Caenorhabditis elegans)


name: mTORC1 phosphorylates MAF1 (Caenorhabditis elegans)


name: Regulation of PTEN gene transcription (Dictyostelium discoideum)


name: mTORC1 phosphorylates MAF1 (Dictyostelium discoideum)


name: MAF1 translocates to the nucleus (Dictyostelium discoideum)


name: Regulation of PTEN gene transcription (Schizosaccharomyces pombe)


name: MAF1 translocates to the nucleus (Schizosaccharomyces pombe)


name: Regulation of PTEN gene transcription (Saccharomyces cerevisiae)


name: MAF1 translocates to the nucleus (Saccharomyces cerevisiae)


name: Regulation of PTEN gene transcription (Plasmodium falciparum)


name: MAF1 translocates to the nucleus (Plasmodium falciparum)


name: Regulation of PTEN stability and activity (Homo sapiens)


name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Homo sapiens)


name: Proteasome degrades polyubiquitinated PTEN (Homo sapiens)


name: PREX2 binds PTEN and inhibits it (Homo sapiens)


name: MKRN1 polyubiquitinates PTEN (Homo sapiens)


name: RNF146 polyubiquitinates PARylated PTEN (Homo sapiens)


name: TNKS and TNKS2 PARylate PTEN (Homo sapiens)


name: Casein kinase II phosphorylates PTEN (Homo sapiens)


name: TRIM27 polyubiquitinates PTEN (Homo sapiens)


name: USP13 and OTUD3 deubiquitinate PTEN (Homo sapiens)


name: Regulation of PTEN stability and activity (Mus musculus)


name: RNF146 polyubiquitinates PARylated PTEN (Mus musculus)


name: TNKS and TNKS2 PARylate PTEN (Mus musculus)


name: TRIM27 polyubiquitinates PTEN (Mus musculus)


name: Casein kinase II phosphorylates PTEN (Mus musculus)


name: PREX2 binds PTEN and inhibits it (Mus musculus)


name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Mus musculus)


name: Proteasome degrades polyubiquitinated PTEN (Mus musculus)


name: USP13 and OTUD3 deubiquitinate PTEN (Mus musculus)


name: MKRN1 polyubiquitinates PTEN (Mus musculus)


name: Regulation of PTEN stability and activity (Rattus norvegicus)


name: PREX2 binds PTEN and inhibits it (Rattus norvegicus)


name: USP13 and OTUD3 deubiquitinate PTEN (Rattus norvegicus)


name: RNF146 polyubiquitinates PARylated PTEN (Rattus norvegicus)


name: TNKS and TNKS2 PARylate PTEN (Rattus norvegicus)


name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Rattus norvegicus)


name: Proteasome degrades polyubiquitinated PTEN (Rattus norvegicus)


name: TRIM27 polyubiquitinates PTEN (Rattus norvegicus)


name: FRK phosphorylates PTEN (Rattus norvegicus)


name: MKRN1 polyubiquitinates PTEN (Rattus norvegicus)


name: Casein kinase II phosphorylates PTEN (Rattus norvegicus)


name: Regulation of PTEN stability and activity (Canis familiaris)


name: TRIM27 polyubiquitinates PTEN (Canis familiaris)


name: USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)


name: RNF146 polyubiquitinates PARylated PTEN (Canis familiaris)


name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Canis familiaris)


name: FRK phosphorylates PTEN (Canis familiaris)


name: Proteasome degrades polyubiquitinated PTEN (Canis familiaris)


name: MKRN1 polyubiquitinates PTEN (Canis familiaris)


name: PREX2 binds PTEN and inhibits it (Canis familiaris)


name: Casein kinase II phosphorylates PTEN (Canis familiaris)


name: TNKS and TNKS2 PARylate PTEN (Canis familiaris)


name: Regulation of PTEN stability and activity (Bos taurus)


name: MKRN1 polyubiquitinates PTEN (Bos taurus)


name: TRIM27 polyubiquitinates PTEN (Bos taurus)


name: USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)


name: Proteasome degrades polyubiquitinated PTEN (Bos taurus)


name: RNF146 polyubiquitinates PARylated PTEN (Bos taurus)


name: TNKS and TNKS2 PARylate PTEN (Bos taurus)


name: PREX2 binds PTEN and inhibits it (Bos taurus)


name: Casein kinase II phosphorylates PTEN (Bos taurus)


name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Bos taurus)


name: Regulation of PTEN stability and activity (Sus scrofa)


name: Proteasome degrades polyubiquitinated PTEN (Sus scrofa)


name: MKRN1 polyubiquitinates PTEN (Sus scrofa)


name: USP13 and OTUD3 deubiquitinate PTEN (Sus scrofa)


name: PREX2 binds PTEN and inhibits it (Sus scrofa)


name: TNKS and TNKS2 PARylate PTEN (Sus scrofa)


name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Sus scrofa)


name: RNF146 polyubiquitinates PARylated PTEN (Sus scrofa)


name: Casein kinase II phosphorylates PTEN (Sus scrofa)


name: TRIM27 polyubiquitinates PTEN (Sus scrofa)


name: Regulation of PTEN stability and activity (Danio rerio)


name: USP13 and OTUD3 deubiquitinate PTEN (Danio rerio)


name: MKRN1 polyubiquitinates PTEN (Danio rerio)


name: Proteasome degrades polyubiquitinated PTEN (Danio rerio)


name: TRIM27 polyubiquitinates PTEN (Danio rerio)


name: RNF146 polyubiquitinates PARylated PTEN (Danio rerio)


name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Danio rerio)


name: Regulation of PTEN stability and activity (Xenopus tropicalis)


name: MKRN1 polyubiquitinates PTEN (Xenopus tropicalis)


name: USP13 and OTUD3 deubiquitinate PTEN (Xenopus tropicalis)


name: PREX2 binds PTEN and inhibits it (Xenopus tropicalis)


name: RNF146 polyubiquitinates PARylated PTEN (Xenopus tropicalis)


name: FRK phosphorylates PTEN (Xenopus tropicalis)


name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Xenopus tropicalis)


name: Regulation of PTEN stability and activity (Gallus gallus)


name: MKRN1 polyubiquitinates PTEN (Gallus gallus)


name: USP13 and OTUD3 deubiquitinate PTEN (Gallus gallus)


name: TNKS and TNKS2 PARylate PTEN (Gallus gallus)


name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Gallus gallus)


name: RNF146 polyubiquitinates PARylated PTEN (Gallus gallus)


name: PREX2 binds PTEN and inhibits it (Gallus gallus)


name: TRIM27 polyubiquitinates PTEN (Gallus gallus)


name: Regulation of PTEN stability and activity (Drosophila melanogaster)


name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Drosophila melanogaster)


name: MKRN1 polyubiquitinates PTEN (Drosophila melanogaster)


name: USP13 and OTUD3 deubiquitinate PTEN (Drosophila melanogaster)


name: RNF146 polyubiquitinates PARylated PTEN (Drosophila melanogaster)


name: Proteasome degrades polyubiquitinated PTEN (Drosophila melanogaster)


name: PTEN binds FRK (Drosophila melanogaster)


name: FRK phosphorylates PTEN (Drosophila melanogaster)


name: Casein kinase II phosphorylates PTEN (Drosophila melanogaster)


name: Regulation of PTEN stability and activity (Caenorhabditis elegans)


name: MKRN1 polyubiquitinates PTEN (Caenorhabditis elegans)


name: TRIM27 polyubiquitinates PTEN (Caenorhabditis elegans)


name: RNF146 polyubiquitinates PARylated PTEN (Caenorhabditis elegans)


name: Proteasome degrades polyubiquitinated PTEN (Caenorhabditis elegans)


name: USP13 and OTUD3 deubiquitinate PTEN (Caenorhabditis elegans)


name: TRIM27 binds PTEN (Caenorhabditis elegans)


name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Caenorhabditis elegans)


name: Casein kinase II phosphorylates PTEN (Caenorhabditis elegans)


name: FRK phosphorylates PTEN (Caenorhabditis elegans)


name: Regulation of PTEN stability and activity (Dictyostelium discoideum)


name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Dictyostelium discoideum)


name: USP13 and OTUD3 deubiquitinate PTEN (Dictyostelium discoideum)


name: Proteasome degrades polyubiquitinated PTEN (Dictyostelium discoideum)


name: MKRN1 polyubiquitinates PTEN (Dictyostelium discoideum)


name: Casein kinase II phosphorylates PTEN (Dictyostelium discoideum)


name: Regulation of PTEN stability and activity (Schizosaccharomyces pombe)


name: Proteasome degrades polyubiquitinated PTEN (Schizosaccharomyces pombe)


name: Casein kinase II phosphorylates PTEN (Schizosaccharomyces pombe)


name: MKRN1 polyubiquitinates PTEN (Schizosaccharomyces pombe)


name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Schizosaccharomyces pombe)


name: USP13 and OTUD3 deubiquitinate PTEN (Schizosaccharomyces pombe)


name: Regulation of PTEN stability and activity (Saccharomyces cerevisiae)


name: Proteasome degrades polyubiquitinated PTEN (Saccharomyces cerevisiae)


name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Saccharomyces cerevisiae)


name: Casein kinase II phosphorylates PTEN (Saccharomyces cerevisiae)


name: PIP3 activates AKT signaling (Mus musculus)


name: PIP3 recruits AKT to the membrane (Mus musculus)


name: RAC1,RAC2,RHOG activate PI3K (Mus musculus)


name: PDPK1 phosphorylates SGK1 (Mus musculus)


name: TORC2 (mTOR) phosphorylates AKT at S473 (Mus musculus)


name: TORC2 complex phosphorylates SGK1 (Mus musculus)


name: PIP3 recruits PDPK1 to the membrane (Mus musculus)


name: Costimulation by the CD28 family (Mus musculus)


name: SHP-1 and SHP-2 bind pBTLA (Mus musculus)


name: CD28 homodimer binds B7-2 monomer (Mus musculus)


name: CD28 homodimer binds B7-1 homodimer (Mus musculus)


name: CD28 dependent Vav1 pathway (Mus musculus)


name: Activation of PAKs by RAC1 and CDC42 (Mus musculus)


name: Activation of Cdc42 by pVav1 (Mus musculus)


name: Translocation of Vav1 to CD28 (Mus musculus)


name: Activation of Rac1 by pVav1 (Mus musculus)


name: CD28 dependent Vav1 pathway (Homo sapiens)


name: Translocation of Vav1 to CD28 (Homo sapiens)


name: Activation of PAKs by RAC1 and CDC42 (Homo sapiens)


name: Activation of Cdc42 by pVav1 (Homo sapiens)


name: Activation of Rac1 by pVav1 (Homo sapiens)


name: CD28 dependent Vav1 pathway (Rattus norvegicus)


name: Activation of Cdc42 by pVav1 (Rattus norvegicus)


name: Activation of PAKs by RAC1 and CDC42 (Rattus norvegicus)


name: Activation of Rac1 by pVav1 (Rattus norvegicus)


name: Translocation of Vav1 to CD28 (Rattus norvegicus)


name: CD28 dependent Vav1 pathway (Canis familiaris)


name: Translocation of Vav1 to CD28 (Canis familiaris)


name: Activation of Cdc42 by pVav1 (Canis familiaris)


name: Activation of PAKs by RAC1 and CDC42 (Canis familiaris)


name: Activation of Rac1 by pVav1 (Canis familiaris)


name: CD28 dependent Vav1 pathway (Bos taurus)


name: Activation of PAKs by RAC1 and CDC42 (Bos taurus)


name: Activation of Cdc42 by pVav1 (Bos taurus)


name: Translocation of Vav1 to CD28 (Bos taurus)


name: Activation of Rac1 by pVav1 (Bos taurus)


name: CD28 dependent Vav1 pathway (Sus scrofa)


name: Activation of PAKs by RAC1 and CDC42 (Sus scrofa)


name: Translocation of Vav1 to CD28 (Sus scrofa)


name: Activation of Rac1 by pVav1 (Sus scrofa)


name: Activation of Cdc42 by pVav1 (Sus scrofa)


name: CD28 dependent Vav1 pathway (Danio rerio)


name: Activation of PAKs by RAC1 and CDC42 (Danio rerio)


name: CD28 dependent Vav1 pathway (Xenopus tropicalis)


name: Translocation of Vav1 to CD28 (Xenopus tropicalis)


name: Activation of Cdc42 by pVav1 (Xenopus tropicalis)


name: Activation of Rac1 by pVav1 (Xenopus tropicalis)


name: Activation of PAKs by RAC1 and CDC42 (Xenopus tropicalis)


name: CD28 dependent Vav1 pathway (Gallus gallus)


name: Activation of Cdc42 by pVav1 (Gallus gallus)


name: Activation of Rac1 by pVav1 (Gallus gallus)


name: Activation of PAKs by RAC1 and CDC42 (Gallus gallus)


name: CD28 dependent Vav1 pathway (Drosophila melanogaster)


name: Activation of PAKs by RAC1 and CDC42 (Drosophila melanogaster)


name: CD28 dependent Vav1 pathway (Caenorhabditis elegans)


name: Activation of PAKs by RAC1 and CDC42 (Caenorhabditis elegans)


name: CD28 dependent Vav1 pathway (Dictyostelium discoideum)


name: Activation of PAKs by RAC1 and CDC42 (Dictyostelium discoideum)


name: CD28 dependent Vav1 pathway (Schizosaccharomyces pombe)


name: Activation of PAKs by RAC1 and CDC42 (Schizosaccharomyces pombe)


name: CD28 dependent Vav1 pathway (Saccharomyces cerevisiae)


name: Activation of PAKs by RAC1 and CDC42 (Saccharomyces cerevisiae)


name: CD28 dependent PI3K/Akt signaling (Mus musculus)


name: AKT interacts and phosphorylates Cot (Mus musculus)


name: CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)


name: p-S400-Cot phosphorylates NIK (Mus musculus)


name: CD28 dependent PI3K/Akt signaling (Homo sapiens)


name: AKT interacts and phosphorylates Cot (Homo sapiens)


name: p-S400-Cot phosphorylates NIK (Homo sapiens)


name: CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)


name: CD28 dependent PI3K/Akt signaling (Rattus norvegicus)


name: TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)


name: AKT interacts and phosphorylates Cot (Rattus norvegicus)


name: PIP3 recruits AKT to the membrane (Rattus norvegicus)


name: CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)


name: p-S400-Cot phosphorylates NIK (Rattus norvegicus)


name: PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)


name: CD28 dependent PI3K/Akt signaling (Canis familiaris)


name: PIP3 recruits PDPK1 to the membrane (Canis familiaris)


name: CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)


name: p-S400-Cot phosphorylates NIK (Canis familiaris)


name: CD28 dependent PI3K/Akt signaling (Bos taurus)


name: CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)


name: PIP3 recruits PDPK1 to the membrane (Bos taurus)


name: p-S400-Cot phosphorylates NIK (Bos taurus)


name: CD28 dependent PI3K/Akt signaling (Sus scrofa)


name: p-S400-Cot phosphorylates NIK (Sus scrofa)


name: PIP3 recruits PDPK1 to the membrane (Sus scrofa)


name: CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)


name: CD28 dependent PI3K/Akt signaling (Danio rerio)


name: PIP3 recruits AKT to the membrane (Danio rerio)


name: PIP3 recruits PDPK1 to the membrane (Danio rerio)


name: CD28 dependent PI3K/Akt signaling (Xenopus tropicalis)


name: p-S400-Cot phosphorylates NIK (Xenopus tropicalis)


name: CD28 bound PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)


name: PIP3 recruits PDPK1 to the membrane (Xenopus tropicalis)


name: CD28 dependent PI3K/Akt signaling (Gallus gallus)


name: CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)


name: AKT interacts and phosphorylates Cot (Gallus gallus)


name: PIP3 recruits AKT to the membrane (Gallus gallus)


name: p-S400-Cot phosphorylates NIK (Gallus gallus)


name: TORC2 (mTOR) phosphorylates AKT at S473 (Gallus gallus)


name: PIP3 recruits PDPK1 to the membrane (Gallus gallus)


name: CD28 dependent PI3K/Akt signaling (Drosophila melanogaster)


name: TORC2 (mTOR) phosphorylates AKT at S473 (Drosophila melanogaster)


name: PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)


name: PIP3 recruits AKT to the membrane (Drosophila melanogaster)


name: AKT binds PDPK1 (Drosophila melanogaster)


name: CD28 dependent PI3K/Akt signaling (Caenorhabditis elegans)


name: PIP3 recruits AKT to the membrane (Caenorhabditis elegans)


name: AKT binds PDPK1 (Caenorhabditis elegans)


name: TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)


name: PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)


name: CD28 dependent PI3K/Akt signaling (Dictyostelium discoideum)


name: TORC2 (mTOR) phosphorylates AKT at S473 (Dictyostelium discoideum)


name: PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)


name: AKT binds PDPK1 (Dictyostelium discoideum)


name: PIP3 recruits AKT to the membrane (Dictyostelium discoideum)


name: CD28 dependent PI3K/Akt signaling (Schizosaccharomyces pombe)


name: PIP3 recruits PDPK1 to the membrane (Schizosaccharomyces pombe)


name: AKT binds PDPK1 (Schizosaccharomyces pombe)


name: TORC2 (mTOR) phosphorylates AKT at S473 (Schizosaccharomyces pombe)


name: PIP3 recruits AKT to the membrane (Schizosaccharomyces pombe)


name: CD28 dependent PI3K/Akt signaling (Saccharomyces cerevisiae)


name: PIP3 recruits PDPK1 to the membrane (Saccharomyces cerevisiae)


name: AKT binds PDPK1 (Saccharomyces cerevisiae)


name: PIP3 recruits AKT to the membrane (Saccharomyces cerevisiae)


name: TORC2 (mTOR) phosphorylates AKT at S473 (Saccharomyces cerevisiae)


name: p-S400-Cot phosphorylates NIK (Saccharomyces cerevisiae)


name: AKT interacts and phosphorylates Cot (Saccharomyces cerevisiae)


name: CD28 dependent PI3K/Akt signaling (Plasmodium falciparum)


name: PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)


name: CD28 homodimer binds B7-1 homodimer (Homo sapiens)


name: CD28 homodimer binds B7-2 monomer (Homo sapiens)


name: CD28 homodimer binds B7-1 homodimer (Rattus norvegicus)


name: Phosphorylation of CD28 (Rattus norvegicus)


name: CD28 homodimer binds B7-2 monomer (Rattus norvegicus)


name: Phosphorylation of CD28 (Canis familiaris)


name: CD28 homodimer binds B7-2 monomer (Canis familiaris)


name: CD28 homodimer binds B7-1 homodimer (Canis familiaris)


name: CD28 homodimer binds B7-2 monomer (Bos taurus)


name: CD28 homodimer binds B7-1 homodimer (Bos taurus)


name: CD28 homodimer binds B7-2 monomer (Sus scrofa)


name: CD28 homodimer binds B7-1 homodimer (Sus scrofa)


name: CD28 co-stimulation (Xenopus tropicalis)


name: Phosphorylation of CD28 (Xenopus tropicalis)


name: CD28 homodimer binds B7-2 monomer (Xenopus tropicalis)


name: CD28 homodimer binds B7-1 homodimer (Xenopus tropicalis)


name: CD28 homodimer binds B7-2 monomer (Gallus gallus)


name: CD28 homodimer binds B7-1 homodimer (Gallus gallus)


name: CTLA4 inhibitory signaling (Mus musculus)


name: SHP2 phosphatase binds CTLA-4 (Mus musculus)


name: Phosphorylation of CTLA-4 (Mus musculus)


name: Dephosphorylation of AKT by PP2A (Mus musculus)


name: CTLA4 inhibitory signaling (Homo sapiens)


name: Dephosphorylation of AKT by PP2A (Homo sapiens)


name: SHP2 phosphatase binds CTLA-4 (Homo sapiens)


name: Phosphorylation of CTLA-4 (Homo sapiens)


name: CTLA4 inhibitory signaling (Rattus norvegicus)


name: Phosphorylation of CTLA-4 (Rattus norvegicus)


name: SHP2 phosphatase binds CTLA-4 (Rattus norvegicus)


name: Dephosphorylation of AKT by PP2A (Rattus norvegicus)


name: CTLA-4 binds B7-1/B7-2 (Rattus norvegicus)


name: PP2A binds CTLA4 dimer (Rattus norvegicus)


name: CTLA4 inhibitory signaling (Canis familiaris)


name: CTLA-4 binds B7-1/B7-2 (Canis familiaris)


name: PP2A binds CTLA4 dimer (Canis familiaris)


name: Phosphorylation of CTLA-4 (Canis familiaris)


name: SHP2 phosphatase binds CTLA-4 (Canis familiaris)


name: SHP2 phosphatase binds CTLA-4 (Bos taurus)


name: SHP2 phosphatase binds CTLA-4 (Sus scrofa)


name: CTLA4 inhibitory signaling (Xenopus tropicalis)


name: SHP2 phosphatase binds CTLA-4 (Xenopus tropicalis)


name: CTLA-4 binds B7-1/B7-2 (Xenopus tropicalis)


name: CTLA4 inhibitory signaling (Gallus gallus)


name: SHP2 phosphatase binds CTLA-4 (Gallus gallus)


name: CTLA4 inhibitory signaling (Drosophila melanogaster)


name: Dephosphorylation of AKT by PP2A (Drosophila melanogaster)


name: CTLA4 inhibitory signaling (Caenorhabditis elegans)


name: Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)


name: CTLA4 inhibitory signaling (Dictyostelium discoideum)


name: Dephosphorylation of AKT by PP2A (Dictyostelium discoideum)


name: CTLA4 inhibitory signaling (Schizosaccharomyces pombe)


name: Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)


name: CTLA4 inhibitory signaling (Saccharomyces cerevisiae)


name: Dephosphorylation of AKT by PP2A (Saccharomyces cerevisiae)


name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)


name: Interaction of SHP-1 or SHP-2 with phospho PD-1 (Mus musculus)


name: PDCD1 binds PDCD1 inhibitors (Mus musculus)


name: PDCD1 binds PDCD1 inhibitors (Homo sapiens)

definition: Inhibition


name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)


name: Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)


name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)


name: PD-1 binds B7DC and B7H1 (Rattus norvegicus)


name: Phosphorylation of PD-1 (Rattus norvegicus)


name: PDCD1 binds PDCD1 inhibitors (Rattus norvegicus)


name: Interaction of SHP-1 or SHP-2 with phospho PD-1 (Rattus norvegicus)


name: PDCD1 binds PDCD1 inhibitors (Canis familiaris)


name: Phosphorylation of PD-1 (Canis familiaris)


name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)


name: Interaction of SHP-1 or SHP-2 with phospho PD-1 (Canis familiaris)


name: PD-1 binds B7DC and B7H1 (Canis familiaris)


name: Interaction of SHP-1 or SHP-2 with phospho PD-1 (Bos taurus)


name: PDCD1 binds PDCD1 inhibitors (Bos taurus)


name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)


name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Sus scrofa)


name: Interaction of SHP-1 or SHP-2 with phospho PD-1 (Sus scrofa)


name: PDCD1 binds PDCD1 inhibitors (Sus scrofa)


name: PDCD1 binds PDCD1 inhibitors (Gallus gallus)


name: Interaction of SHP-1 or SHP-2 with phospho PD-1 (Gallus gallus)


name: PD-1 binds B7DC and B7H1 (Gallus gallus)


name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Gallus gallus)


name: Costimulation by the CD28 family (Homo sapiens)


name: SHP-1 and SHP-2 bind pBTLA (Homo sapiens)


name: HVEM induses BTLA phosphorylation (Homo sapiens)


name: Costimulation by the CD28 family (Rattus norvegicus)


name: SHP-1 and SHP-2 bind pBTLA (Rattus norvegicus)


name: BTLA interacts with HVEM (Rattus norvegicus)


name: ICOS binds ICOSL/B7-H2 (Rattus norvegicus)


name: Costimulation by the CD28 family (Canis familiaris)


name: SHP-1 and SHP-2 bind pBTLA (Canis familiaris)


name: BTLA interacts with HVEM (Canis familiaris)


name: ICOS binds ICOSL/B7-H2 (Canis familiaris)


name: Costimulation by the CD28 family (Bos taurus)


name: Costimulation by the CD28 family (Sus scrofa)


name: Costimulation by the CD28 family (Xenopus tropicalis)


name: Costimulation by the CD28 family (Gallus gallus)


name: CD22 mediated BCR regulation (Mus musculus)


name: CD22 binds itself to form homo-oligomers (Mus musculus)


name: CD22 binds B-cell receptor (Mus musculus)


name: CD22 mediated BCR regulation (Homo sapiens)


name: CD22 binds itself to form homo-oligomers (Homo sapiens)


name: CD22 binds B-cell receptor (Homo sapiens)


name: CD22 mediated BCR regulation (Rattus norvegicus)


name: CD22 binds itself to form homo-oligomers (Rattus norvegicus)


name: LYN phosphorylates CD22 (Rattus norvegicus)


name: CD22 binds B-cell receptor (Rattus norvegicus)


name: CD22 mediated BCR regulation (Canis familiaris)


name: CD22 binds itself to form homo-oligomers (Canis familiaris)


name: LYN phosphorylates CD22 (Canis familiaris)


name: CD22 binds B-cell receptor (Canis familiaris)


name: CD22 mediated BCR regulation (Bos taurus)


name: CD22 binds itself to form homo-oligomers (Bos taurus)


name: CD22 mediated BCR regulation (Sus scrofa)


name: CD22 binds itself to form homo-oligomers (Sus scrofa)


name: CD22 mediated BCR regulation (Xenopus tropicalis)


name: CD22 binds itself to form homo-oligomers (Xenopus tropicalis)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)


name: p-DAPP1 (p-BAM32) binds PLCG2 (Mus musculus)


name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)


name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)


name: p-6Y-SYK phosphorylates BLNK (SLP65) (Mus musculus)


name: SYK binds the activated BCR (Mus musculus)


name: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)


name: p-CD19:VAV binds PI3K and GRB2 (Mus musculus)


name: TRPC1 translocates calcium from the extracellular region to the cytosol (Mus musculus)


name: SYK autophosphorylates at the activated BCR (Mus musculus)


name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Mus musculus)


name: STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Mus musculus)


name: PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Mus musculus)


name: The Immunoglobulin of the BCR binds antigen (Mus musculus)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)


name: Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)


name: p-SYK and LYN phosphorylate BTK (Homo sapiens)


name: p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)


name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)


name: TRPC1 translocates calcium from the extracellular region to the cytosol (Homo sapiens)


name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)


name: IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)


name: LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) (Homo sapiens)


name: IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)


name: SYK autophosphorylates at the activated BCR (Homo sapiens)


name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)


name: p-6Y-SYK phosphorylates BLNK (SLP65) (Homo sapiens)


name: STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Homo sapiens)


name: SYK binds the activated BCR (Homo sapiens)


name: The Immunoglobulin of the BCR binds antigen (Homo sapiens)


name: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)


store-operated calcium channel activity

description: A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.


name: p-CD19:VAV binds PI3K and GRB2 (Homo sapiens)


name: PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Homo sapiens)


name: p-DAPP1 (p-BAM32) binds PLCG2 (Homo sapiens)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)


name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Rattus norvegicus)


name: SYK autophosphorylates at the activated BCR (Rattus norvegicus)


name: The Immunoglobulin of the BCR binds antigen (Rattus norvegicus)


name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)


name: TRPC1 translocates calcium from the extracellular region to the cytosol (Rattus norvegicus)


name: STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Rattus norvegicus)


name: p-6Y-SYK phosphorylates BLNK (SLP65) (Rattus norvegicus)


name: PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Rattus norvegicus)


name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)


name: BTK binds BTK inhibitors (Rattus norvegicus)


name: SYK binds the activated BCR (Rattus norvegicus)


name: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)


name: p-DAPP1 (p-BAM32) binds PLCG2 (Rattus norvegicus)


name: p-CD19:VAV binds PI3K and GRB2 (Rattus norvegicus)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)


name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)


name: PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Canis familiaris)


name: STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Canis familiaris)


name: p-CD19:VAV binds PI3K and GRB2 (Canis familiaris)


name: SYK binds the activated BCR (Canis familiaris)


name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)


name: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)


name: p-6Y-SYK phosphorylates BLNK (SLP65) (Canis familiaris)


name: p-DAPP1 (p-BAM32) binds PLCG2 (Canis familiaris)


name: TRPC1 translocates calcium from the extracellular region to the cytosol (Canis familiaris)


name: BTK binds BTK inhibitors (Canis familiaris)


name: The Immunoglobulin of the BCR binds antigen (Canis familiaris)


name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)


name: SYK autophosphorylates at the activated BCR (Canis familiaris)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)


name: STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Bos taurus)


name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)


name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Bos taurus)


name: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)


name: TRPC1 translocates calcium from the extracellular region to the cytosol (Bos taurus)


name: SYK binds the activated BCR (Bos taurus)


name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Bos taurus)


name: p-6Y-SYK phosphorylates BLNK (SLP65) (Bos taurus)


name: PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Bos taurus)


name: p-CD19:VAV binds PI3K and GRB2 (Bos taurus)


name: p-DAPP1 (p-BAM32) binds PLCG2 (Bos taurus)


name: SYK autophosphorylates at the activated BCR (Bos taurus)


name: The Immunoglobulin of the BCR binds antigen (Bos taurus)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Sus scrofa)


name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)


name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)


name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Sus scrofa)


name: SYK autophosphorylates at the activated BCR (Sus scrofa)


name: The Immunoglobulin of the BCR binds antigen (Sus scrofa)


name: PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Sus scrofa)


name: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)


name: p-CD19:VAV binds PI3K and GRB2 (Sus scrofa)


name: p-DAPP1 (p-BAM32) binds PLCG2 (Sus scrofa)


name: STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Sus scrofa)


name: SYK binds the activated BCR (Sus scrofa)


name: TRPC1 translocates calcium from the extracellular region to the cytosol (Sus scrofa)


name: p-6Y-SYK phosphorylates BLNK (SLP65) (Sus scrofa)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Danio rerio)


name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)


name: PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Danio rerio)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Xenopus tropicalis)


name: STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Xenopus tropicalis)


name: p-DAPP1 (p-BAM32) binds PLCG2 (Xenopus tropicalis)


name: TRPC1 translocates calcium from the extracellular region to the cytosol (Xenopus tropicalis)


name: PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Xenopus tropicalis)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Gallus gallus)


name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Gallus gallus)


name: p-DAPP1 (p-BAM32) binds PLCG2 (Gallus gallus)


name: SYK binds the activated BCR (Gallus gallus)


name: BTK binds BTK inhibitors (Gallus gallus)


name: p-6Y-SYK phosphorylates BLNK (SLP65) (Gallus gallus)


name: The Immunoglobulin of the BCR binds antigen (Gallus gallus)


name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Gallus gallus)


name: TRPC1 translocates calcium from the extracellular region to the cytosol (Gallus gallus)


name: PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Gallus gallus)


name: STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Gallus gallus)


name: SYK autophosphorylates at the activated BCR (Gallus gallus)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Drosophila melanogaster)


name: STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Drosophila melanogaster)


name: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)


name: TRPC1 translocates calcium from the extracellular region to the cytosol (Drosophila melanogaster)


name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)


name: STIM1 oligomerizes (Drosophila melanogaster)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Caenorhabditis elegans)


name: STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Caenorhabditis elegans)


name: TRPC1 translocates calcium from the extracellular region to the cytosol (Caenorhabditis elegans)


name: STIM1 oligomerizes (Caenorhabditis elegans)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Dictyostelium discoideum)


name: PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Dictyostelium discoideum)


name: p-DAPP1 (p-BAM32) binds PLCG2 (Dictyostelium discoideum)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Schizosaccharomyces pombe)


name: PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Schizosaccharomyces pombe)


name: p-DAPP1 (p-BAM32) binds PLCG2 (Schizosaccharomyces pombe)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Saccharomyces cerevisiae)


name: PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Saccharomyces cerevisiae)


name: p-DAPP1 (p-BAM32) binds PLCG2 (Saccharomyces cerevisiae)


name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Plasmodium falciparum)


name: PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Plasmodium falciparum)


name: p-DAPP1 (p-BAM32) binds PLCG2 (Plasmodium falciparum)


name: Activation of NF-kappaB in B cells (Mus musculus)


name: NF-kappaB translocates from the cytosol to the nucleus (Mus musculus)


name: CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Mus musculus)


name: PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Mus musculus)


name: Ubiquitinated IkB is degraded (Mus musculus)


name: Activated IKK phosphorylates I-kappaB (Mus musculus)


name: SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Mus musculus)


name: PRKCB (PKC-beta) phosphorylates CARMA1 (Mus musculus)


name: SCF-beta-TrCP ubiquitinylates IkB (Mus musculus)


name: Activation of NF-kappaB in B cells (Homo sapiens)


name: TAK1 associated with the CBM complex phosphorylates IKKbeta (Homo sapiens)


name: Ubiquitinated IkB is degraded (Homo sapiens)


name: SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)


name: SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)


name: PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Homo sapiens)


name: CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Homo sapiens)


name: NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)


name: PRKCB (PKC-beta) phosphorylates CARMA1 (Homo sapiens)


name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK (Homo sapiens)


name: Activated IKK phosphorylates I-kappaB (Homo sapiens)


name: Activation of NF-kappaB in B cells (Rattus norvegicus)


name: SCF-beta-TrCP ubiquitinylates IkB (Rattus norvegicus)


name: SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Rattus norvegicus)


name: Activated IKK phosphorylates I-kappaB (Rattus norvegicus)


name: PRKCB (PKC-beta) phosphorylates CARMA1 (Rattus norvegicus)


name: Ubiquitinated IkB is degraded (Rattus norvegicus)


name: PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Rattus norvegicus)


name: CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Rattus norvegicus)


name: NF-kappaB translocates from the cytosol to the nucleus (Rattus norvegicus)


name: Activation of NF-kappaB in B cells (Canis familiaris)


name: CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Canis familiaris)


name: SCF-beta-TrCP ubiquitinylates IkB (Canis familiaris)


name: Activated IKK phosphorylates I-kappaB (Canis familiaris)


name: PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Canis familiaris)


name: NF-kappaB translocates from the cytosol to the nucleus (Canis familiaris)


name: SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Canis familiaris)


name: PRKCB (PKC-beta) phosphorylates CARMA1 (Canis familiaris)


name: Ubiquitinated IkB is degraded (Canis familiaris)


name: Activation of NF-kappaB in B cells (Bos taurus)


name: Ubiquitinated IkB is degraded (Bos taurus)


name: SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Bos taurus)


name: PRKCB (PKC-beta) phosphorylates CARMA1 (Bos taurus)


name: PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Bos taurus)


name: SCF-beta-TrCP ubiquitinylates IkB (Bos taurus)


name: Activated IKK phosphorylates I-kappaB (Bos taurus)


name: NF-kappaB translocates from the cytosol to the nucleus (Bos taurus)


name: CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Bos taurus)


name: Activation of NF-kappaB in B cells (Sus scrofa)


name: Activated IKK phosphorylates I-kappaB (Sus scrofa)


name: CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Sus scrofa)


name: NF-kappaB translocates from the cytosol to the nucleus (Sus scrofa)


name: Ubiquitinated IkB is degraded (Sus scrofa)


name: Activation of NF-kappaB in B cells (Danio rerio)


name: PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Danio rerio)


name: Ubiquitinated IkB is degraded (Danio rerio)


name: NF-kappaB translocates from the cytosol to the nucleus (Danio rerio)


name: Activation of NF-kappaB in B cells (Xenopus tropicalis)


name: NF-kappaB translocates from the cytosol to the nucleus (Xenopus tropicalis)


name: PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Xenopus tropicalis)


name: PRKCB (PKC-beta) phosphorylates CARMA1 (Xenopus tropicalis)


name: SCF-beta-TrCP ubiquitinylates IkB (Xenopus tropicalis)


name: SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Xenopus tropicalis)


name: Activation of NF-kappaB in B cells (Gallus gallus)


name: CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Gallus gallus)


name: PRKCB (PKC-beta) phosphorylates CARMA1 (Gallus gallus)


name: SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Gallus gallus)


name: SCF-beta-TrCP ubiquitinylates IkB (Gallus gallus)


name: NF-kappaB translocates from the cytosol to the nucleus (Gallus gallus)


name: PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Gallus gallus)


name: Activation of NF-kappaB in B cells (Drosophila melanogaster)


name: PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Drosophila melanogaster)


name: Ubiquitinated IkB is degraded (Drosophila melanogaster)


name: Activated IKK phosphorylates I-kappaB (Drosophila melanogaster)


name: NF-kappaB translocates from the cytosol to the nucleus (Drosophila melanogaster)


name: Activation of NF-kappaB in B cells (Caenorhabditis elegans)


name: PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Caenorhabditis elegans)


name: Activation of NF-kappaB in B cells (Dictyostelium discoideum)


name: PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Dictyostelium discoideum)


name: Activation of NF-kappaB in B cells (Schizosaccharomyces pombe)


name: PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Schizosaccharomyces pombe)


name: Activation of NF-kappaB in B cells (Saccharomyces cerevisiae)


name: PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Saccharomyces cerevisiae)


name: Calcineurin activates NFAT (Mus musculus)


name: Calcineurin binds NFATC1,2,3 (Mus musculus)


name: Calcineurin activates NFAT (Homo sapiens)


name: Calcineurin binds NFATC1,2,3 (Homo sapiens)


name: calcium-dependent protein serine/threonine phosphatase activity

description: Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions.


name: Calcineurin activates NFAT (Rattus norvegicus)


name: Calcineurin binds NFATC1,2,3 (Rattus norvegicus)


name: FKBP1A binds tacrolimus (Rattus norvegicus)


name: Calcineurin activates NFAT (Canis familiaris)


name: FKBP1A binds tacrolimus (Canis familiaris)


name: Calcineurin binds NFATC1,2,3 (Canis familiaris)


name: Calcineurin binds NFATC1,2,3 (Bos taurus)


name: Calcineurin binds NFATC1,2,3 (Sus scrofa)


name: Calcineurin activates NFAT (Danio rerio)


name: Calcineurin activates NFAT (Xenopus tropicalis)


name: FKBP1A binds tacrolimus (Xenopus tropicalis)


name: Calcineurin activates NFAT (Gallus gallus)


name: Calcineurin binds NFATC1,2,3 (Gallus gallus)


name: Calcineurin activates NFAT (Drosophila melanogaster)


name: FKBP1A binds tacrolimus (Drosophila melanogaster)


name: Calcineurin binds NFATC1,2,3 (Drosophila melanogaster)


name: Calcineurin activates NFAT (Caenorhabditis elegans)


name: FKBP1A binds tacrolimus (Caenorhabditis elegans)


name: Calcineurin activates NFAT (Dictyostelium discoideum)


name: FKBP1A binds tacrolimus (Dictyostelium discoideum)


name: Calcineurin activates NFAT (Schizosaccharomyces pombe)


name: FKBP1A binds tacrolimus (Schizosaccharomyces pombe)


name: Calcineurin activates NFAT (Saccharomyces cerevisiae)


name: FKBP1A binds tacrolimus (Saccharomyces cerevisiae)


name: Activation of RAS in B cells (Mus musculus)


name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Mus musculus)


name: Activation of RAS in B cells (Homo sapiens)


name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Homo sapiens)


name: RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated (Homo sapiens)


name: Activation of RAS in B cells (Rattus norvegicus)


name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Rattus norvegicus)


name: Activation of RAS in B cells (Canis familiaris)


name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Canis familiaris)


name: Activation of RAS in B cells (Bos taurus)


name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Bos taurus)


name: Activation of RAS in B cells (Sus scrofa)


name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Sus scrofa)


name: Activation of RAS in B cells (Danio rerio)


name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Danio rerio)


name: Activation of RAS in B cells (Xenopus tropicalis)


name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Xenopus tropicalis)


name: Activation of RAS in B cells (Gallus gallus)


name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Gallus gallus)


name: Activation of RAS in B cells (Caenorhabditis elegans)


name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Caenorhabditis elegans)


name: PIP3 activates AKT signaling (Rattus norvegicus)


name: RAC1,RAC2,RHOG activate PI3K (Rattus norvegicus)


name: PDPK1 phosphorylates SGK1 (Rattus norvegicus)


name: TORC2 complex phosphorylates SGK1 (Rattus norvegicus)


name: Signaling by SCF-KIT (Rattus norvegicus)


name: GRB2 is indirectly recruited to p-KIT through SHP2 (Rattus norvegicus)


name: PTP-RO interacts with p-c-Kit complex (Rattus norvegicus)


name: Autophosphorylation of KIT (Rattus norvegicus)


name: KIT binds type I TKIs (Rattus norvegicus)


name: Phosphorylation of p-KIT on Y900 by Src kinases (Rattus norvegicus)


name: Phosphorylation of GAB2 by SFKs (Rattus norvegicus)


name: KIT binds type II TKIs (Rattus norvegicus)


name: Indirect recruitment of GAB2 to p-KIT (Rattus norvegicus)


name: Phosphorylation of SHP2 by SFKs (Rattus norvegicus)


name: Activation of RAS by p-KIT bound SOS1 (Rattus norvegicus)


name: Recruitment of STATs (Rattus norvegicus)


name: SHP2 interacts with p-KIT (Rattus norvegicus)


name: Interaction of KIT and sSCF (Rattus norvegicus)


name: KIT binds ripretinib (Rattus norvegicus)


name: Phosphorylation of STATs (Rattus norvegicus)


name: Interaction of other adapter proteins with p-KIT (Rattus norvegicus)


name: Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)


name: Dimerization of sSCF (Rattus norvegicus)


name: Interaction of other tyrosine kinases with p-KIT (Rattus norvegicus)


name: Processing of SCF isoform 1 (Rattus norvegicus)


name: Dimerization of STATs (Rattus norvegicus)


name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Rattus norvegicus)


name: Disassociation and translocation of STATs to the nucleus (Rattus norvegicus)


name: GRB2:SOS interacts with p-KIT (Rattus norvegicus)


name: Phosphorylation and activation of VAV1 (Rattus norvegicus)


name: Direct recruitment of PI3K to p-KIT (Rattus norvegicus)


name: Phosphorylation of JAK2 (Rattus norvegicus)


name: Dimerization of KIT upon SCF binding (Rattus norvegicus)


name: Regulation of KIT signaling (Rattus norvegicus)


name: Interaction of APS and p-KIT (Rattus norvegicus)


name: PKC alpha interacts with and phosphorylates KIT (Rattus norvegicus)


name: Phosphorylation of APS (Rattus norvegicus)


name: Interaction of SHP1 and KIT (Rattus norvegicus)


name: Recruitment of CBL to KIT (Rattus norvegicus)


name: Regulation of KIT signaling (Homo sapiens)


name: Recruitment of CBL to KIT (Homo sapiens)


name: Downregulation of c-Kit signaling by SOCS6 (Homo sapiens)


name: Interaction of SHP1 and KIT (Homo sapiens)


name: LNK binds to p-KIT and inhibit downstream signaling (Homo sapiens)


name: SOCS1 as a regulator of KIT signaling (Homo sapiens)


name: Interaction of APS and p-KIT (Homo sapiens)


name: PKC alpha interacts with and phosphorylates KIT (Homo sapiens)


name: Regulation of KIT signaling (Mus musculus)


name: LNK binds to p-KIT and inhibit downstream signaling (Mus musculus)


name: Recruitment of CBL to KIT (Mus musculus)


name: Interaction of SHP1 and KIT (Mus musculus)


name: PKC alpha interacts with and phosphorylates KIT (Mus musculus)


name: Interaction of APS and p-KIT (Mus musculus)


name: Regulation of KIT signaling (Canis familiaris)


name: Interaction of APS and p-KIT (Canis familiaris)


name: LNK binds to p-KIT and inhibit downstream signaling (Canis familiaris)


name: PKC alpha interacts with and phosphorylates KIT (Canis familiaris)


name: Recruitment of CBL to KIT (Canis familiaris)


name: Interaction of SHP1 and KIT (Canis familiaris)


name: Phosphorylation of APS (Canis familiaris)


name: Regulation of KIT signaling (Bos taurus)


name: Interaction of APS and p-KIT (Bos taurus)


name: Interaction of SHP1 and KIT (Bos taurus)


name: LNK binds to p-KIT and inhibit downstream signaling (Bos taurus)


name: Regulation of KIT signaling (Sus scrofa)


name: LNK binds to p-KIT and inhibit downstream signaling (Sus scrofa)


name: Interaction of APS and p-KIT (Sus scrofa)


name: PKC alpha interacts with and phosphorylates KIT (Sus scrofa)


name: Interaction of SHP1 and KIT (Sus scrofa)


name: Regulation of KIT signaling (Danio rerio)


name: Regulation of KIT signaling (Xenopus tropicalis)


name: Interaction of APS and p-KIT (Xenopus tropicalis)


name: Phosphorylation of APS (Xenopus tropicalis)


name: LNK binds to p-KIT and inhibit downstream signaling (Xenopus tropicalis)


name: Regulation of KIT signaling (Gallus gallus)


name: LNK binds to p-KIT and inhibit downstream signaling (Gallus gallus)


name: PKC alpha interacts with and phosphorylates KIT (Gallus gallus)


name: Recruitment of CBL to KIT (Gallus gallus)


name: Interaction of SHP1 and KIT (Gallus gallus)


name: Regulation of KIT signaling (Drosophila melanogaster)


name: Phosphorylation of APS (Drosophila melanogaster)


name: PKC alpha interacts with and phosphorylates KIT (Drosophila melanogaster)


name: Recruitment of CBL to KIT (Drosophila melanogaster)


name: Regulation of KIT signaling (Caenorhabditis elegans)


name: PKC alpha interacts with and phosphorylates KIT (Caenorhabditis elegans)


name: Recruitment of CBL to KIT (Caenorhabditis elegans)


name: RAF/MAP kinase cascade (Rattus norvegicus)


name: Intrinsic nucleotide exchange on RAS (Rattus norvegicus)


name: RAS:GTP binds PI3K (Rattus norvegicus)


name: RAS:GTP binds RAL GDS proteins (Rattus norvegicus)


name: RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)


name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Rattus norvegicus)


name: Regulation of RAS by GAPs (Rattus norvegicus)


name: KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Rattus norvegicus)


name: SPRED dimer binds NF1 (Rattus norvegicus)


name: RAS GAPs stimulate RAS GTPase activity (Rattus norvegicus)


name: NF1 is degraded by the proteasome (Rattus norvegicus)


name: RAS GAPs bind RAS:GTP (Rattus norvegicus)


name: Regulation of RAS by GAPs (Homo sapiens)


name: KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Homo sapiens)


name: NF1 is degraded by the proteasome (Homo sapiens)


name: RAS GAPs stimulate RAS GTPase activity (Homo sapiens)


name: Regulation of RAS by GAPs (Mus musculus)


name: RAS GAPs stimulate RAS GTPase activity (Mus musculus)


name: NF1 is degraded by the proteasome (Mus musculus)


name: KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Mus musculus)


name: Regulation of RAS by GAPs (Canis familiaris)


name: RAS GAPs stimulate RAS GTPase activity (Canis familiaris)


name: SPRED dimer binds NF1 (Canis familiaris)


name: NF1 is degraded by the proteasome (Canis familiaris)


name: RAS GAPs bind RAS:GTP (Canis familiaris)


name: KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Sus scrofa)


name: NF1 is degraded by the proteasome (Sus scrofa)


name: RAS GAPs stimulate RAS GTPase activity (Sus scrofa)


name: Regulation of RAS by GAPs (Gallus gallus)


name: RAS GAPs stimulate RAS GTPase activity (Gallus gallus)


name: Regulation of RAS by GAPs (Drosophila melanogaster)


name: KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Drosophila melanogaster)


name: RAS GAPs bind RAS:GTP (Drosophila melanogaster)


name: NF1 is degraded by the proteasome (Drosophila melanogaster)


name: SPRED dimer binds NF1 (Drosophila melanogaster)


name: RAS GAPs stimulate RAS GTPase activity (Drosophila melanogaster)


name: Regulation of RAS by GAPs (Dictyostelium discoideum)


name: SPRED dimer binds NF1 (Dictyostelium discoideum)


name: KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Dictyostelium discoideum)


name: NF1 is degraded by the proteasome (Dictyostelium discoideum)


name: MAP2K and MAPK activation (Rattus norvegicus)


name: Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)


name: MAP2Ks phosphorylate MAPK at the Golgi membrane (Rattus norvegicus)


name: Dissociation of RAS:RAF complex (Rattus norvegicus)


name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)


name: RAF phosphorylates MAP2K dimer (Rattus norvegicus)


name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Rattus norvegicus)


name: IL17RD binds p-2S MAP2Ks and MAPKs (Rattus norvegicus)


name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Rattus norvegicus)


name: Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)


name: Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)


name: MAP2Ks phosphorylate MAPKs (Rattus norvegicus)


name: MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)


name: MAP2K and MAPK activation (Homo sapiens)


name: Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)


name: Dissociation of RAS:RAF complex (Homo sapiens)


name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Homo sapiens)


name: MAP2Ks phosphorylate MAPK at the Golgi membrane (Homo sapiens)


name: RAF phosphorylates MAP2K dimer (Homo sapiens)


name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)


name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)


name: IL17RD binds p-2S MAP2Ks and MAPKs (Homo sapiens)


name: MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)


name: MAP2Ks phosphorylate MAPKs (Homo sapiens)


name: Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)


name: Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)


name: MAP2K and MAPK activation (Mus musculus)


name: Dissociation of RAS:RAF complex (Mus musculus)


name: Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)


name: MAP2Ks phosphorylate MAPK at the Golgi membrane (Mus musculus)


name: RAF phosphorylates MAP2K dimer (Mus musculus)


name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)


name: IL17RD binds p-2S MAP2Ks and MAPKs (Mus musculus)


name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Mus musculus)


name: Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)


name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Mus musculus)


name: Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)


name: MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)


name: MAP2Ks phosphorylate MAPKs (Mus musculus)


name: MAP2K and MAPK activation (Canis familiaris)


name: Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)


name: RAF phosphorylates MAP2K dimer (Canis familiaris)


name: Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)


name: MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)


name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)


name: Dissociation of RAS:RAF complex (Canis familiaris)


name: MAP2Ks phosphorylate MAPK at the Golgi membrane (Canis familiaris)


name: Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)


name: MAP2Ks phosphorylate MAPKs (Canis familiaris)


name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Canis familiaris)


name: IL17RD binds p-2S MAP2Ks and MAPKs (Canis familiaris)


name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Canis familiaris)


name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)


name: MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)


name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)


name: Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)


name: IL17RD binds p-2S MAP2Ks and MAPKs (Bos taurus)


name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Bos taurus)


name: MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)


name: RAF phosphorylates MAP2K dimer (Bos taurus)


name: Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)


name: Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)


name: Dissociation of RAS:RAF complex (Bos taurus)


name: Dual mechanism MAPK inhibitors bind MAPKs (Sus scrofa)


name: MAP2Ks and MAPKs bind to the activated RAF complex (Sus scrofa)


name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Sus scrofa)


name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Sus scrofa)


name: IL17RD binds p-2S MAP2Ks and MAPKs (Sus scrofa)


name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Sus scrofa)


name: Single mechanism MAPK inhibitors bind phosphorylated MAPK (Sus scrofa)


name: RAF phosphorylates MAP2K dimer (Sus scrofa)


name: MAP2Ks phosphorylate MAPK at the Golgi membrane (Sus scrofa)


name: Dissociation of RAS:RAF complex (Sus scrofa)


name: Dual mechanism MAP2K inhibitors bind MAP2Ks (Sus scrofa)


name: IL17RD binds p-2S MAP2Ks and MAPKs (Danio rerio)


name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Danio rerio)


name: MAP2Ks phosphorylate MAPK at the Golgi membrane (Danio rerio)


name: MAP2K and MAPK activation (Gallus gallus)


name: MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)


name: Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)


name: Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)


name: IL17RD binds p-2S MAP2Ks and MAPKs (Gallus gallus)


name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)


name: MAP2Ks phosphorylate MAPKs (Gallus gallus)


name: Dissociation of RAS:RAF complex (Gallus gallus)


name: Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)


name: MAP2Ks phosphorylate MAPK at the Golgi membrane (Gallus gallus)


name: RAF phosphorylates MAP2K dimer (Gallus gallus)


name: MAP2K and MAPK activation (Drosophila melanogaster)


name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Drosophila melanogaster)


name: Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)


name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Drosophila melanogaster)