name: Stage IVA Mycosis Fungoides and Sezary Syndrome AJCC v7

description: Stage IVA includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone.  (AJCC 7th ed.)


Burkitt's lymphoma refractory

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Burkitt lymphoma that is resistant to treatment.


Extranodal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from an anatomic site other than a lymph node.


T-cell childhood lymphoblastic lymphoma

description: A T lymphoblastic lymphoma that occurs during childhood.


Mycosis fungoides/Sezary syndrome

description: Mature T and NK neoplasms predominantly affecting the skin and the peripheral blood.  Peripheral blood involvement by abnormal T-cells (cerebriform cells) is a late manifestation of mycosis fungoides, whereas it is the presenting finding in Sezary syndrome.


name: Localized Anaplastic Large Cell Lymphoma

description: Anaplastic large cell lymphoma that is confined to a specific site without evidence of spread to other anatomic sites.


name: Conjunctival Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises from the conjunctiva.


name: B-Cell Non-Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for B-cell non-Hodgkin lymphoma based on the Ann Arbor classification criteria.


name: non-Hodgkin's lymphoma of accessory sinus

description: A non-Hodgkin lymphoma that arises from the paranasal sinus.  Representative examples include diffuse large B-cell lymphoma and extranodal NK/T-cell lymphoma, nasal type.


Cecum Non-Hodgkin Lymphoma

description: An extranodal non-Hodgkin lymphoma that arises from the cecum.  The majority are B-cell non-Hodgkin lymphomas.


Cutaneous Follicular Lymphoma

description: A follicular lymphoma involving the skin.  A cutaneous follicular lymphoma may be metastatic to the skin from the lymph nodes or other anatomic sites or primary (cutaneous follicle center lymphoma).


name: Stage III Childhood Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood

description: Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disease of childhood is a rare and very aggressive neoplastic disease emerging after a primary acute or chronic active EBV infection. It presents with persisting fever and malaise, hepatosplenomegaly with or without lymphadenopathy, liver failure, severe pancytopenia and a rapid progression towards multi-organ failure and hemophagocytic syndrome with a fatal issue. It is characterized by clonal proliferation of EBV-infected T cells with an activated cytotoxic phenotype.


Systemic Anaplastic Large Cell Lymphoma

description: An anaplastic large cell lymphoma that is not confined to a single anatomic site and involves multiple nodal and/or extranodal sites.


name: High Grade B-Cell Lymphoma with MYC and BCL6 Rearrangements

description: High-grade B-cell lymphoma characterized by the abnormal rearrangement of MYC and BCL6 genes.


name: Head and Neck Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

description: An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that affects the head and neck region. It usually arises from the ocular adnexa and salivary glands.


name: Lacrimal System Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises from the lacrimal gland or the lacrimal drainage system.


name: Primary mediastinal large B-cell lymphoma recurrent

description: The reemergence of primary mediastinal large B-cell lymphoma after a period of remission.


Stage II Adult Burkitt Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Marginal zone lymphoma recurrent

description: The reemergence of marginal zone lymphoma after a period of remission.


name: Ann Arbor Stage IIX (Bulky) Diffuse Large B-Cell Lymphoma

description: Ann Arbor Stage II diffuse large B-cell lymphoma with a mass of nodes with one diameter more than 10cm or a mediastinal mass larger than one third of the transthoracic width. (Cotswolds modification)


name: Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of a marginal zone lymphoma to an aggressive diffuse large B-cell lymphoma.


name: Cutaneous Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type

description: Follicular helper T-cell lymphoma, angioimmunoblastic-type affecting the skin.


Diffuse follicle center lymphoma

description: A lymphoma with the morphologic and immunophenotypic features of a follicular lymphoma characterized by the presence of a diffuse growth pattern with only focal and usually small micronodular foci.


Stage I Adult Immunoblastic Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Intestinal T-cell lymphoma refractory

description: Enteropathy-associated T-cell lymphoma that is resistant to treatment.


name: Colorectal Mucosa-Associated Lymphoid Tissue Lymphoma

description: An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the colon or rectum.


name: Childhood EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: An EBV-positive diffuse large B-cell lymphoma, not otherwise specified, that occurs during childhood. It was originally described in patients older than 50 years, but it has been increasingly recognized in younger patients.


name: Ann Arbor Stage II Non-Contiguous Adult Non-Hodgkin Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Refractory Aggressive B-Cell Non-Hodgkin Lymphoma

description: An aggressive B-cell non-Hodgkin lymphoma that is resistant to treatment.


name: Recurrent Aggressive T-Cell Non-Hodgkin Lymphoma

description: The reemergence of an aggressive T-cell non-Hodgkin lymphoma after a period of remission.


name: Primary Vitreoretinal Diffuse Large B-Cell Lymphoma

description: An uncommon and potentially fatal diffuse large B-cell lymphoma that involves the uvea, retina, vitreous body, and optic nerve. It is a subset of primary central nervous system diffuse large B-cell lymphoma.


Stage II Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


name: Primary cutaneous diffuse large cell B-cell lymphoma

description: A diffuse large B-cell lymphoma that arises from the skin. This category includes primary cutaneous diffuse large B-cell lymphoma, leg type, and primary cutaneous diffuse large B-cell lymphoma, other, which includes primary cutaneous intravascular large B-cell lymphoma and primary cutaneous T-cell/histiocyte-rich large B-cell lymphoma.


name: B-cell small lymphocytic lymphoma stage I


mantle cell lymphoma of small intestine

description: A mantle cell lymphoma that arises from the small intestine.  It may present as an isolated mass in the small intestine or as a part of the multiple lymphomatous polyposis.


Refractory T Lymphoblastic Lymphoma

description: T-lymphoblastic lymphoma that does not respond to treatment.


name: High Grade B-Cell Lymphoma with MYC and BCL2 Rearrangements

description: High-grade B-cell lymphoma characterized by the abnormal rearrangement of MYC and BCL2 genes.


name: Recurrent Grade III Lymphomatoid Granulomatosis


name: Childhood Systemic Anaplastic Large Cell Lymphoma

description: A systemic anaplastic large cell lymphoma that occurs during childhood.


Pituitary Gland Non-Hodgkin Lymphoma

description: A rare non-Hodgkin lymphoma that arises from the pituitary gland. The majority are diffuse large B-cell lymphomas.


Parotid Gland Follicular Lymphoma

description: A follicular lymphoma that manifests initially in the parotid gland.


name: Recurrent ALK-Positive Large B-Cell Lymphoma

description: The reemergence of ALK-positive large B-cell lymphoma after a period of remission.


name: Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood non-Hodgkin lymphoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


High grade B-cell lymphoma refractory

description: High-grade B-cell lymphoma that is resistant to treatment.


name: Systemic Anaplastic Large Cell Lymphoma, ALK-Negative

description: Anaplastic large cell lymphoma, ALK-negative affecting multiple anatomic sites.


Burkitt lymphoma associated with AIDS

description: A Burkitt lymphoma occurring in HIV-positive patients.


MCD diffuse large B-cell lymphoma

description: A diffuse large B-cell lymphoma that is categorized as MCD with high probability by the LymphGen algorithm. This is based on a combination of genetic features and MCD DLBCLs often, but do not always, have the most common hot spot mutation in MYD88 (L265P) and/or activating mutations in CD79B. This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting PIM1 and/or ETV6, which can be coding or non-coding.


name: Childhood Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

description: A mature T- and NK-cell non-Hodgkin lymphoma that occurs during childhood.


name: primary cutaneous diffuse large B-cell lymphoma, Leg type

description: An aggressive primary cutaneous B-cell lymphoma, usually involving the lower leg. It is composed of a generally monotonous proliferation of immunoblasts, or less frequently centroblasts, with few admixed reactive cells. This type of lymphoma occurs most often in elderly women who present with rapidly growing tumors, usually on one or both legs. Dissemination to extracutaneous sites is frequent. Treatment with combination chemotherapy is usually required.


name: Stage IV Childhood Anaplastic Large Cell Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Chronic Adult T-Cell Leukemia/Lymphoma

description: An adult T-cell leukemia/ lymphoma associated with skin lesions and mild lymphadenopathy.  Neoplastic lymphocytes are not numerous in the peripheral blood.  Hypercalcemia is absent.


name: Splenic marginal zone lymphoma recurrent

description: The reemergence of splenic marginal zone lymphoma after a period of remission.


Mycosis fungoides stage III

description: Stage III includes: (T4, N0-2, M0, B0-1); IIIA (T4, N0-2, M0, B0); IIIB (T4, N0-2, M0, B1). T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


name: Central Nervous System Intravascular Large B-Cell Lymphoma

description: A rare extranodal B-cell non-Hodgkin lymphoma that affects the central nervous system.  It is characterized by the presence of lymphoma cells exclusively in the lumina of small vessels, particularly capillaries.


name: Ann Arbor Stage II Non-Contiguous Adult Lymphoblastic Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


mantle cell lymphoma

description: Mantle cell lymphoma is a rare form of malignant non-Hodgkin lymphoma affecting B lymphocytes in the lymph nodes in a region called the ``mantle zone''.


name: Early Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

description: Primary cutaneous T-cell non-Hodgkin lymphoma that has spread from its original site of growth to nearby tissues.


name: Lymphoplasmacytoid lymphoma/immunocytoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Stage II Childhood Lymphoblastic Lymphoma

description: Stage II: Disease extent is limited to a single tumor with regional node involvement, 2 or more tumors or nodal areas involved on one side of the diaphragm, or a primary gastrointestinal tract tumor (completely resected) with or without regional node involvement (from PDQ).


Stage III Adult Immunoblastic Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: central nervous system non-hodgkin lymphoma

description: A non-Hodgkin lymphoma that arises from the central nervous system.


name: Recurrent Indolent Adult Non-Hodgkin Lymphoma

description: The reemergence of indolent non-Hodgkin lymphoma in adults after a period of remission.


name: adult nasal type extranodal NK/T-cell lymphoma

description: Nasal type extranodal NK/T-cell lymphoma that occurs in adulthood.


Splenic B Lymphoblastic Lymphoma

description: B-lymphoblastic lymphoma that involves the spleen.


name: Follicular Helper T-Cell Lymphoma, Not Otherwise Specified

description: Follicular helper T-cell lymphoma that does not meet the criteria for any other specifically defined entity of follicular helper T-cell lymphoma.


T-cell lymphoma refractory

description: T-cell non-Hodgkin lymphoma that is resistant to treatment.


name: Advanced Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

description: Primary cutaneous T-cell non-Hodgkin lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Transformed Lymphoplasmacytic Lymphoma to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of a lymphoplasmacytic lymphoma to an aggressive diffuse large B-cell lymphoma.


B-cell lymphoma refractory

description: B-cell non-Hodgkin lymphoma that is resistant to treatment.


hepatosplenic T-cell lymphoma

description: An extranodal, mature T-cell non-Hodgkin lymphoma that originates from cytotoxic T-cells, usually of gamma/delta T-cell type. It is characterized by the presence of medium-size neoplastic lymphocytes infiltrating the hepatic sinusoids. A similar infiltrating pattern is also present in the spleen and bone marrow that are usually involved at the time of the diagnosis.


name: Ann Arbor Stage I Childhood Non-Hodgkin Lymphoma


name: Ann Arbor Stage II Contiguous Mantle Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Recurrent Grade 3b Follicular Lymphoma

description: The reemergence of grade 3b follicular lymphoma after a period of remission.


name: Stage II Non-Contiguous Adult Indolent Non-Hodgkin Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood non-Hodgkin lymphoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


name: Extranodal marginal zone B-cell lymphoma (MALT type) stage IV

description: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage IV disease.


AIDS-Related Lymphoblastic Lymphoma

description: A lymphoblastic lymphoma occurring in HIV-positive patients.


Centroblastic lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


granulomatous slack skin disease

description: Granulomatous slack skin (GSS) is a variant of mycosis fungoides (MF), a form of cutaneous T-cell lymphoma, and is characterized by the presence of circumscribed areas of pendulous lax skin.


EBV-Related Non-Hodgkin Lymphoma

description: Non-Hodgkin lymphoma that is caused by Epstein-Barr virus infection.


Stage I Anaplastic Large Cell Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: splenic diffuse red pulp small B-cell lymphoma

description: Splenic diffuse red pulp small B-cell lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma characterized by abnormal proliferation of small, monomorphous, basophilic B-lymphocytes, with villous cytoplasm, in the splenic red pulp, bone marrow and peripheral blood. It typically presents in the late clinical stages with splenomegaly and moderate lymphocytosis. Cytopenias are rare and likely associated with hypersplenism.


Splenic Lymphoblastic Lymphoma

description: Lymphoblastic lymphoma that affects the spleen.


name: Head and Neck Pediatric-Type Follicular Lymphoma

description: A pediatric-type follicular lymphoma that affects the head and neck region.


Centroblastic lymphoma refractory

description: Centroblastic lymphoma, resistant to treatment.


name: Stage III Mycosis Fungoides and Sezary Syndrome AJCC v7

description: Stage III includes: (T4, N0-2, M0, B0-1); IIIA (T4, N0-2, M0, B0); IIIB (T4, N0-2, M0, B1). T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Recurrent Immunoblastic Lymphoma

description: The reemergence of immunoblastic lymphoma after a period of remission.


name: Stage IIIB Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IIIB includes: T4, N0-2, M0, B1. T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


EBV-Negative Burkitt Lymphoma

description: Burkitt lymphoma that is not associated with Epstein-Barr virus infection.


Leukemic Nonnodal Mantle Cell Lymphoma

description: Mantle cell lymphoma involving the peripheral blood, bone marrow, and often spleen. It usually has an indolent clinical course.


Aggressive Adult Non-Hodgkin Lymphoma

description: An aggressive non-Hodgkin lymphoma occurring in adults.  Representative examples include Burkitt lymphoma, precursor B-lymphoblastic lymphoma, precursor T-lymphoblastic lymphoma, and adult T-cell lymphoma/leukemia.


Recurrent Adult Burkitt Lymphoma

description: The reemergence of adult Burkitt lymphoma after a period of remission.


Advanced Diffuse Large B-Cell Lymphoma

description: Diffuse large B-cell lymphoma that has spread extensively to distant anatomic sites or is no longer responding to treatment.


name: Refractory Indolent T-Cell Non-Hodgkin Lymphoma

description: Indolent T-cell non-Hodgkin lymphoma that is resistant to treatment.


name: Refractory Indolent Non-Hodgkin Lymphoma

description: Indolent non-Hodgkin lymphoma that is resistant to treatment.


name: Mycosis Fungoides and Sezary Syndrome by AJCC v8 Stage

description: A term that refers to the staging of mycosis fungoides and Sezary syndrome, following the rules of the TNM AJCC v8 classification system. This prognostic stage groups system is based on the ISCL/EORTC revision to the staging of mycosis fungoides and Sezary syndrome. There is no prognostic stage groups system for primary cutaneous B-cell/T-cell (non-mycosis fungoides/Sezary syndrome) lymphomas at this time. This staging system does not apply to eyelid skin lymphomas (are staged according to the classification for ocular adnexal lymphoma).  (from AJCC 8th Ed.)


name: Refractory Transformed B-Cell Non-Hodgkin Lymphoma

description: An indolent B-cell non-Hodgkin lymphoma which has undergone histologic transformation to an aggressive B-cell non-Hodgkin lymphoma and has become resistant to treatment.


name: Bladder Mucosa-Associated Lymphoid Tissue Lymphoma

description: A rare mucosa-associated lymphoid tissue lymphoma affecting the bladder.


name: Primary mediastinal large B-cell lymphoma refractory

description: Primary mediastinal large B-cell lymphoma that is resistant to treatment.


description: Burkitt lymphoma in a patient with immunodeficiency.


Recurrent Grade 2 Follicular Lymphoma

description: The reemergence of grade 2 follicular lymphoma after a period of remission.


B-cell lymphoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Stage IA Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IA includes: T1, N0, M0, B0,1. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


name: Diffuse Large B-Cell Lymphoma, Not Otherwise Specified by Gene Expression Profile

description: A header term that includes the following diffuse large B-cell lymphoma subtypes by gene expression profiling: activated B-cell-like diffuse large B-cell lymphoma, germinal center B-cell-like diffuse large B-cell lymphoma, and type 3 diffuse large B-cell lymphoma.


name: Recurrent Childhood Grade III Lymphomatoid Granulomatosis

description: The reemergence of grade III lymphomatoid granulomatosis in childhood after a period of remission.


name: primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma

description: Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma is a rare form of primary cutaneous T-cell lymphoma characterized by rapidly progressing, localized or disseminated nodules, tumors or eczematous skin lesions. It has a particularly aggressive clinical course with a high tendency to spread, in advanced stages, to extracutaneous locations (the central nervous system, lung, testes). Lymph nodes are often spared.


name: Refractory Intravascular Large B-Cell Lymphoma

description: Intravascular large B-cell lymphoma that is resistant to treatment.


name: Ann Arbor Stage IV Grade 1 Follicular Lymphoma


Pleural Primary Effusion Lymphoma

description: Primary effusion lymphoma that affects the pleural cavity. The majority of patients are HIV-positive men.


Favorable Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma with favorable prognosis.


ocular adnexal lymphoma

description: A non-Hodgkin lymphoma arising from the conjunctiva, lacrimal gland, lacrimal drainage apparatus, eyelids, or other orbital tissues around the eye. The vast majority of cases are extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue, however, other histologic types of lymphomas can originate from ocular adnexal tissues, including rare cases of NK/T-cell lymphomas of nasal type.


name: Advanced Stage Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of CNS and/or bone marrow. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma

description: Primary cutaneous diffuse large B-cell lymphoma that is resistant to treatment.


name: Ann Arbor Stage II Non-Contiguous Adult Burkitt Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Salivary Gland Mucosa-Associated Lymphoid Tissue Lymphoma

description: A low-grade extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue arising from a salivary gland. It usually occurs in the parotid gland and is often associated with Sjogren syndrome. The prognosis is favorable.


high grade B-cell lymphoma

description: A term that refers to high grade B-cell lymphoma, not otherwise specified or high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements.


name: Ann Arbor Stage I Grade 3 Follicular Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Recurrent Subcutaneous Panniculitis-Like T-Cell Lymphoma

description: The reemergence of subcutaneous panniculitis-like T-cell lymphoma after a period of remission.


name: Ann Arbor Stage II Nodular Lymphocyte Predominant B-Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Pediatric nodal marginal zone lymphoma

description: A nodal marginal zone lymphoma affecting the pediatric population, predominantly males.  It presents with asymptomatic and localized (mainly head and neck) disease in the vast majority of cases.  Morphologically there is often progressive transformation of the germinal centers.  The prognosis is excellent.


retina lymphoma

description: A lymphoma that involves the retina.


name: Refractory NK-Cell Lymphoma, Unclassifiable

description: NK-cell lymphoma, unclassifiable that is resistant to treatment.


name: Refractory Follicular Helper T-Cell Lymphoma, Follicular-Type

description: Follicular helper T-cell lymphoma, follicular-type that is resistant to treatment.


Pancreatic Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the pancreas with the bulk of the tumor localized to this organ.  The vast majority of cases are of B-cell phenotype and include mucosa-associated lymphoid tissue lymphomas, follicular lymphomas, and diffuse large B-cell lymphomas.


name: Precursor B-lymphoblastic lymphoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Body Cavity Primary Effusion Lymphoma

description: A large B-cell lymphoma presenting as a serous effusion without detectable tumor masses. It is universally associated with human herpes virus 8 (HHV8), also called Kaposi sarcoma-associated herpesvirus.  It mostly occurs in the setting of immunodeficiency. The most common sites of involvement are the pleural, pericardial, and peritoneal cavities. (WHO 2017)


name: B-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical Hodgkin lymphoma

description: A group of lymphomas displaying molecular, morphologic, immunophenotypic, and clinical overlap between classical Hodgkin lymphoma and diffuse large B-cell lymphoma. This term particularly applies to mediastinal lymphomas with overlapping features of mediastinal (thymic) large B-cell lymphoma and classical Hodgkin lymphoma.


Stage II Adult Immunoblastic Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


Stage IA Mycosis Fungoides AJCC v7

description: Stage IA includes: T1, N0, M0, B0-1.  T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


name: Small Intestinal T-Cell Non-Hodgkin Lymphoma

description: A T-cell non-Hodgkin lymphoma that arises from the small intestine.  It includes the enteropathy-associated T-cell lymphoma and the monomorphic CD56 positive intestinal T-cell lymphoma.


name: Stage II Contiguous Adult Indolent Non-Hodgkin Lymphoma


Angiocentric lymphoma refractory

description: Nasal type extranodal NK/T-cell lymphoma that does not respond to treatment.


AIDS-Related Plasmablastic Lymphoma

description: A plasmablastic lymphoma in a patient with acquired immunodeficiency syndrome.


name: High Grade B-Cell Lymphoma, Not Otherwise Specified

description: High-grade B-cell lymphoma with blastoid features or features between diffuse large B-cell lymphoma and Burkitt lymphoma that lacks MYC, BCL2, and BCL6 gene rearrangements.


Pediatric follicular lymphoma

description: A nodal follicular lymphoma with favorable prognosis. It lacks BCL-2 rearrangement and 14;18 translocation. Nearly all cases are localized. It is usually seen in the pediatric population but similar lymphomas may occur in adults.


Sinonasal Extranodal NK/T-Cell Lymphoma

description: An extranodal NK/T-cell lymphoma that arises from the sinonasal tract.


large B-cell diffuse lymphoma of kidney

description: A diffuse large B-cell lymphoma that affects the kidney.


name: Diffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder

description: A diffuse large B-cell lymphoma that arises in a patient with a history of organ transplantation.


Lymphoma, Mixed-Cell, Follicular

description: A follicular lymphoma which contains 6-15 centroblasts per 40X high-power microscopic field.


EZB diffuse large B-cell lymphoma

description: A diffuse large B-cell lymphoma that is categorized as EZB with high probability by the LymphGen algorithm. This is based on a combination of genetic features and EZB DLBCLs often, but do not always, have hot spot mutations in EZH2 and/or a BCL2 translocation. This class can be further subdivided into two sub-classes EZB-MYC+ and EZB-MYC- using the double hit gene expression signature (DHITsig). This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting IRF8, which can be coding or non-coding.


B-cell lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Recurrent Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma

description: The reemergence of primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma after a period of remission.


name: Anaplastic Large Cell Lymphoma, Giant Cell Rich Subtype

description: An anaplastic large cell lymphoma characterized by the presence of numerous giant cells.


Cutaneous Mantle Cell Lymphoma

description: Mantle cell lymphoma that affects the skin.


name: Ann Arbor Stage II Grade 2 Follicular Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: The reemergence of diffuse large B-cell lymphoma, not otherwise specified after a period of remission.


Recurrent T Lymphoblastic Lymphoma

description: The reemergence of T-lymphoblastic lymphoma after a period of remission.


name: Centroblastic Lymphoma Post-Transplant Lymphoproliferative Disorder

description: A centroblastic lymphoma that arises in a patient with a history of organ transplantation.


name: HHV-8 and EBV-Negative Primary Effusion-Based Lymphoma

description: An HHV-8 and EBV-negative primary effusion-based lymphoma that affects elderly, HIV-negative patients with history of medical conditions that result in fluid overload. The majority of cases have been reported in Japan. Most tumors exhibit centroblastic or immunoblastic morphology. The prognosis is good.


name: Refractory Transformed Mycosis Fungoides

description: Transformed mycosis fungoides that is resistant to treatment.


name: B-cell small lymphocytic lymphoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Lacrimal System Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the lacrimal gland or the lacrimal drainage system. The majority of cases are of B-cell type. The most common subtypes are mucosa-associated lymphoid tissue lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma.


Childhood Non-Hodgkin Lymphoma

description: Non-Hodgkin lymphoma occurring in childhood.


Stage I Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Small Lymphocytic Lymphoma with Plasmacytoid Differentiation

description: A small lymphocytic lymphoma characterized by the presence of neoplastic lymphocytes with plasmacytoid morphology.


Intestinal T-Cell Lymphoma

description: A group of mature T-cell and NK-cell non-Hodgkin lymphomas that includes enteropathy-associated T-cell lymphoma, monomorphic epitheliotropic intestinal T-cell lymphoma, and intestinal T-cell lymphoma, not otherwise specified. Most of these lymphomas arise from the small intestine and a minority from the large intestine or stomach.


name: Head and Neck Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises from the head and neck region. It affects both lymph nodes and extranodal sites. The most frequently affected extranodal site is the Waldeyer ring, particularly the palatine tonsil.


Duodenal-type follicular lymphoma

description: A localized low-grade follicular lymphoma within the gastrointestinal tract, which is distinct from other gastrointestinal tract follicular lymphomas.  It has features that overlap with in situ follicular neoplasia as well as some features resembling an extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. The prognosis is excellent.


name: Lymphoplasmacytoid lymphoma/immunocytoma stage IV


Oropharyngeal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the oropharynx.


name: Stage I Indolent Adult Non-Hodgkin Lymphoma


Mantle cell lymphoma recurrent

description: The reemergence of a mantle cell lymphoma after a period of remission.


name: Lugano Classification Stage II Bulky Adult Non-Hodgkin Lymphoma AJCC v8

description: Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


name: Lymphomatous Adult T-Cell Leukemia/Lymphoma

description: An adult T-cell leukemia/lymphoma characterized by generalized lymphadenopathy without peripheral blood involvement.  Most patients have advanced disease, however hypercalcemia is not frequently present.


name: Pleomorphic Variant Mantle Cell Lymphoma

description: An aggressive mantle cell lymphoma characterized by the presence of pleomorphic neoplastic B-lymphocytes.


Burkitt's lymphoma of spleen

description: Burkitt lymphoma that involves the spleen.


name: Stage IV Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

description: Initial CNS and/or bone marrow involvement. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Major Salivary Gland Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the parotid gland, submandibular gland, or sublingual gland.  Representative examples include mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma.


name: Ann Arbor Stage II Grade 3 Non-Contiguous Follicular Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Lymphoplasmacytoid lymphoma/immunocytoma stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Recurrent NK-Cell Lymphoma, Unclassifiable

description: The reemergence of NK-cell lymphoma, unclassifiable after a period of remission.


name: Diffuse large B-cell lymphoma, unclassifiable, NOS

description: A biologic subset of diffuse large B-cell lymphomas (DLBCL) that do not overexpress the genes whose overexpression characterizes the germinal center B-cell-like and activated B-cell-like DLBCL.  Morphologically, these lymphomas are either immunoblastic or centroblastic.  Patients with this type of diffuse large B-cell lymphoma are reported to have a less favorable outcome, similar to those with an activated B-cell-like gene expression profile.


name: Recurrent Follicular Helper T-Cell Lymphoma, Follicular-Type

description: The reemergence of follicular helper T-cell lymphoma, follicular-type after a period of remission.


name: Stage IVA2 Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IVA2 includes: T1-4, N3, M0, B0-2. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). T4: Confluence of erythema covering 80% or more of body surface area. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1,000 per microliter or more Sezary cells with positive clone. (AJCC 8th ed.)


mycosis fungoides variant

description: A header term that includes the rare following variants of mycosis fungoides: folliculotropic mycosis fungoides, granulomatous slack skin disease, and pagetoid reticulosis.


Primary Bone Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the bone, without lymph node or other extranodal involvement.  The femur, spine, and pelvic bones are the most frequently affected areas.  The majority of cases are diffuse large B-cell lymphomas.  Most patients present with pain in the affected area.  Systemic symptoms are rare.


name: Recurrent Primary Vitreoretinal Non-Hodgkin Lymphoma

description: The reemergence of primary vitreoretinal non-Hodgkin lymphoma after a period of remission.


name: Stage I Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage I includes: IA (T1, N0, M0, B0,1); IB (T2, N0, M0, B0,1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


name: Methotrexate-Associated Peripheral T-Cell Lymphoma

description: A peripheral T-cell lymphoma that develops in patients who are immunosuppressed with methotrexate.


intravascular large B-cell lymphoma

description: Intravascular large B-cell lymphoma (IVLBCL) is a very rare form of diffuse large B-cell lymphoma characterized by the selective growth of lymphoma cells within the lumina of small blood vessels (especially the capillaries) that most often presents with a wide range of clinical manifestations (as potentially any tissue can be involved), with patients from Western countries more frequently manifesting with neurological and cutaneous symptoms while patients from Asian countries more frequently displaying hepatosplenomegaly and thrombocytopenia. IVLBCL is characterized by an absence of lymphadenopathy, an aggressive clinical course and a poor prognosis.


name: Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: Diffuse large B-cell lymphoma, not otherwise specified that is resistant to treatment.


Refractory Lymphoblastic Lymphoma

description: Lymphoblastic lymphoma that is resistant to treatment.


name: Ann Arbor Stage II Grade 2 Non-Contiguous Follicular Lymphoma


Refractory Grade 3b Follicular Lymphoma

description: Grade 3b follicular lymphoma that is resistant to treatment.


Stage IV Adult Lymphoblastic Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Small Intestinal Monomorphic Epitheliotropic T-Cell Lymphoma

description: A monomorphic epitheliotropic intestinal T-cell lymphoma arising from the small intestine. It is characterized by the presence of a monomorphic cellular infiltrate of small to medium-sized T-lymphocytes that are cytotoxic and express CD56. It is not associated with celiac disease.


Methotrexate-Related Burkitt Lymphoma

description: A Burkitt lymphoma that develops in patients who are immunosuppressed with methotrexate.


name: Ann Arbor Stage II Grade 3 Contiguous Follicular Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Stage II Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage II includes: IIA (T1,2, N1,2, M0, B0,1); IIB (T3, N0-2, M0, B0,1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


name: Recurrent Extranodal Diffuse Large B-cell Lymphoma

description: The reemergence of extranodal diffuse large B-cell lymphoma after a period of remission.


name: Nodal marginal zone B-cell lymphoma stage IV


Cutaneous Burkitt Lymphoma

description: Burkitt lymphoma that affects the skin.


large B-cell diffuse lymphoma of heart

description: A diffuse large B-cell lymphoma that arises from the heart.


name: large B-cell diffuse lymphoma of accessory sinus

description: A non-Hodgkin lymphoma that arises from the paranasal sinus and is characterized by the presence of a diffuse malignant infiltrate composed of large B-lymphocytes.


name: Ann Arbor Stage III Grade 2 Follicular Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Stage IIA Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IIA includes:  T1-2, N1,2, M0, B0,1. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Digestive System Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from any part of the digestive system, with the bulk of the disease localized to that site.


name: Ann Arbor Stage II Contiguous Adult Lymphoblastic Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Non-Hodgkin's lymphoma transformed recurrent

description: The reemergence of non-Hodgkin lymphoma transformed after a period of remission.


name: Recurrent Anaplastic Large Cell Lymphoma

description: The reemergence of anaplastic large cell lymphoma after a period of remission.


Marginal zone lymphoma stage II

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (PDQ)


name: Esophageal Diffuse Large B-Cell Lymphoma

description: An extranodal diffuse large B-cell lymphoma that arises from the esophagus with the bulk of the mass located in the esophagus.


name: Angioimmunoblastic T-cell lymphoma refractory

description: Follicular helper T-cell lymphoma, angioimmunoblastic-type that is resistant to treatment.


name: Refractory Indolent Adult Non-Hodgkin Lymphoma

description: Indolent adult non-Hodgkin lymphoma that is resistant to treatment.


Childhood Lymphoblastic Lymphoma

description: A lymphoblastic lymphoma occurring in children.


description: A follicular lymphoma that develops in patients who are immunosuppressed with methotrexate.


name: Mantle Cell Lymphoma with CCND2 Rearrangement

description: Mantle cell lymphoma characterized by the presence of CCND2 gene rearrangement. A small number of cases express this gene rearrangement and not CCND1 gene rearrangement.


name: Recurrent High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements

description: The reemergence of high-grade B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements after a period of remission.


name: Stage IVB Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IVB includes: T1-4, N0-3, M1, B0-2. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M1: Visceral involvement (must have pathology confirmation and organ involved should be specified). B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1,000 per microliter or more Sezary cells with positive clone. (AJCC 8th ed.)


name: Advanced Unfavorable Non-Hodgkin Lymphoma

description: A clinical stage II or IV non-Hodgkin lymphoma with at least four of the following risk factors: albumin level less than 4.0 g/dl, hemoglobin level of less than 10.5 g/dl, male sex, forty-five years of age or older, stage IV disease, white cell count of at least 15,000 per cubic millimeter, absolute lymphocytic count of less than 600 per cubic millimeter or a lymphocytic count of less than 8% of the total white cell count.


name: Recurrent High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements

description: The reemergence of high-grade B-cell lymphoma with MYC, BCL2, and BCL6 rearrangements after a period of remission.


name: Cutaneous Adult T-Cell Leukemia/Lymphoma

description: Adult T-cell leukemia/lymphoma affecting the skin.


Recurrent Plasmablastic Lymphoma

description: The reemergence of plasmablastic lymphoma after a period of remission.


name: primary mediastinal large B-cell lymphoma

description: A large B-cell non-Hodgkin lymphoma arising in the mediastinum. Morphologically it is characterized by a massive diffuse lymphocytic proliferation associated with compartmentalizing fibrosis. Response to intensive chemotherapy, with or without radiotherapy, is usually good. (WHO, 2001)


name: Stage I Childhood Anaplastic Large Cell Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Endometrial Mucosa-Associated Lymphoid Tissue Lymphoma

description: A rare extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue affecting the endometrium.


NK-Cell Lymphoma, Unclassifiable

description: A very rare NK-cell lymphoma with pathologic and clinical features posing difficulty in its exact diagnosis and classification.


name: Central Nervous System Anaplastic Large Cell Lymphoma, ALK-Positive

description: An anaplastic large cell lymphoma, ALK-positive, arising from the central nervous system.


name: large B-cell diffuse lymphoma of nasal cavity

description: A non-Hodgkin lymphoma that arises from the nasal cavity and is characterized by the presence of a diffuse malignant infiltrate composed of large B-lymphocytes.


name: St. Jude Stage IV Childhood Non-Hodgkin Lymphoma AJCC v8

description: Stage IV: Any tumor, with initial CNS and/or bone marrow involvement. (from AJCC 8th Ed.)


name: St. Jude Childhood Non-Hodgkin Lymphoma by AJCC v8 Stage

description: A staging system for childhood non-Hodgkin Lymphomas based on the St. Jude Children's Research Hospital staging system. The Ann Arbor staging system has been found to be inappropriate for staging of the non-Hodgkin lymphomas of childhood. The St. Jude staging system has been widely accepted for more than three decades and remains the recommended staging system for childhood non-Hodgkin lymphomas. (from AJCC 8th Ed.)


Marginal zone lymphoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Recurrent Adult Grade III Lymphomatoid Granulomatosis

description: The reemergence of grade III lymphomatoid granulomatosis in adulthood after a period of remission.


mediastinal gray zone lymphoma

description: A mediastinal lymphoma with molecular, morphologic, immunophenotypic, and clinical features of both mediastinal (thymic) large B-cell lymphoma and classical Hodgkin lymphoma. The identification of this group of lymphomas, along with recent gene expression profiling results (PDL2 gene expression in both mediastinal (thymic) large B-cell lymphoma tissues and Hodgkin lymphoma cell lines), further supports the hypothesis that mediastinal (thymic) large B-cell lymphomas and classical Hodgkin lymphomas are related entities.


name: Recurrent Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

description: The reemergence of diffuse large B-cell lymphoma that resulted from the transformation of indolent B-cell non-Hodgkin lymphoma, after a period of remission.


name: Ann Arbor Stage III Nodular Lymphocyte Predominant B-Cell Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Refractory Extranodal Diffuse Large B-cell Lymphoma

description: Extranodal diffuse large B-cell lymphoma that is resistant to treatment.


name: Ann Arbor Stage II Childhood Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Refractory Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

description: Diffuse large B-cell lymphoma that resulted from the transformation of indolent B-cell non-Hodgkin lymphoma and is resistant to treatment.


angioimmunoblastic T-cell lymphoma

description: A mature T-cell non-Hodgkin lymphoma, characterized by systemic disease and a polymorphous infiltrate involving lymph nodes and extranodal sites. The clinical course is typically aggressive.


name: Refractory Monomorphic Epitheliotropic Intestinal T-cell Lymphoma

description: Monomorphic epitheliotropic intestinal T-cell lymphoma that is resistant to treatment.


name: Adult Grade III Lymphomatoid Granulomatosis

description: Grade III lymphomatoid granulomatosis that occurs in adulthood.


Cyclin D1-Negative Mantle Cell Lymphoma

description: A molecular subtype of mantle cell lymphoma characterized by the absence of cyclin D1 expression and CCND1 rearrangement.


name: Recurrent Aggressive B-Cell Non-Hodgkin Lymphoma

description: The reemergence of an aggressive B-cell non-Hodgkin lymphoma after a period of remission.


Peritoneal Primary Effusion Lymphoma

description: Primary effusion lymphoma that affects the peritoneal cavity. The majority of patients are HIV-positive men.


name: T-Cell Non-Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for T-cell non-Hodgkin lymphoma based on the Ann Arbor classification criteria.


Sezary syndrome

description: Sezary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma characterized by a triad of erythroderma, lymphadenopathy and circulating atypical lymphocytes (Sezary cells).


Non-Hodgkin's lymphoma of prostate

description: A rare non-Hodgkin lymphoma that arises from the prostate gland.


name: Lymphoma, Small Cleaved-Cell, Follicular

description: A follicular lymphoma which contains up to 5 centroblasts per 40X high-power microscopic field.


name: Noncutaneous Childhood Anaplastic Large Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for noncutaneous childhood anaplastic large cell lymphoma based on the Ann Arbor classification criteria.


Advanced Favorable Non-Hodgkin Lymphoma

description: A clinical stage II or IV non-Hodgkin lymphoma with up to three of the following risk factors: albumin level less than 4.0 g/dl, hemoglobin level of less than 10.5 g/dl, male sex, forty-five years of age or older, stage IV disease, white cell count of at least 15,000 per cubic millimeter, absolute lymphocytic count of less than 600 per cubic millimeter or a lymphocytic count of less than 8% of the total white cell count.


name: Large B-cell lymphoma with IRF4 rearrangement

description: A large B-cell lymphoma that usually affects the Waldeyer ring and/or cervical lymph nodes and less often the gastrointestinal tract. It occurs most commonly in children and young adults and is low stage. It is characterized by a follicular, follicular and diffuse, or pure diffuse growth pattern resembling follicular lymphoma grade 3B or a diffuse large B-cell lymphoma. Most cases have IG/IRF4 rearrangements. BCL2 rearrangements are not present. Some cases that belong in this category lack an IRF4 rearrangement but have strong IRF4/MUM1 expression. This lymphoma is more aggressive than pediatric-type follicular lymphomas.


Angiocentric lymphoma recurrent

description: The reemergence of nasal type extranodal NK/T-cell lymphoma after a period of remission.


Stage IV Anaplastic Large Cell Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Refractory Immunoblastic Lymphoma

description: Immunoblastic lymphoma that is resistant to treatment.


name: Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of a follicular lymphoma to an aggressive diffuse large B-cell lymphoma.


Classical Burkitt Lymphoma

description: A Burkitt lymphoma characterized by the presence of a uniform malignant lymphocytic infiltrate that is composed of medium-sized cells with round nuclei and multiple basophilic nucleoli, abundant mitotic figures, and a starry-sky pattern due to the presence of multiple tangible body macrophages.


name: Precursor B-lymphoblastic lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Splenic marginal zone lymphoma refractory

description: Splenic marginal zone lymphoma that is resistant to treatment.


N1 diffuse large B-cell lymphoma

description: A diffuse large B-cell lymphoma that is categorized as N1 with high probability by the LymphGen algorithm. This is based on a combination of genetic features. Although N1 DLBCLs always have an activating mutation affecting NOTCH1, LymphGen can assign cases with this mutation to other classes, depending on the presence of other genetic features.


name: Immunoblastic lymphoma associated with AIDS

description: A morphologic variant of diffuse large B-cell lymphoma occurring in HIV-positive patients.


Peripheral T-Cell Lymphoma-TBX21

description: A molecular subtype of peripheral T-cell lymphoma, not otherwise specified, characterized by high expression of T-box 21 (TBX21). It is composed of a polymorphic lymphocytic infiltrate admixed with abundant inflammatory cells and is associated with a better prognosis compared to peripheral T-cell lymphoma-GATA3.


name: Secondary Choroidal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that has spread to the choroid following the initial presentation in another nodal or extranodal site.


name: Refractory ALK-Positive Large B-Cell Lymphoma

description: ALK-positive large B-cell lymphoma that is resistant to treatment.


Stage III Burkitt Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Follicular lymphoma refractory

description: Follicular lymphoma grade I, II, III that is resistant to treatment.


Follicular lymphoma recurrent

description: The reemergence of follicular lymphoma after a period of remission.


name: Limited Stage Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

description: No involvement of CNS and no involvement of bone marrow. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


lymphoplasmacytic lymphoma

description: A clonal neoplasm of small B-lymphocytes, lymphoplasmacytoid cells, and plasma cells involving the bone marrow, lymph nodes, and the spleen. The majority of patients have a serum IgM paraprotein.


T-cell lymphoma recurrent

description: The reemergence of T-cell non-Hodgkin lymphoma after a period of remission.


name: Lugano Classification Adult Non-Hodgkin Lymphoma by AJCC v8 Stage

description: A staging system for adult non-Hodgkin lymphomas based on the Lugano classification criteria. This staging system does not apply to ocular adnexal lymphomas (are staged according to the classification for ocular adnexal lymphoma), pediatric non-Hodgkin lymphomas (are staged according to the St. Jude Children's Research Hospital staging system), primary cutaneous lymphomas (are staged according to the classification for primary cutaneous lymphoma), and multiple myelomas (are staged according to the classification for plasma cell myeloma). (from AJCC 8th Ed.)


name: Refractory High Grade B-Cell Lymphoma, Not Otherwise Specified

description: High-grade B-cell lymphoma, not otherwise specified, that is resistant to treatment.


name: Stage IV Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IV includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2); IVB (T1-4, N0-3, M1, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M0: No visceral organ involvement.  M1: Visceral involvement (must have pathology confirmation and organ involved should be specified). B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1,000 per microliter or more Sezary cells with positive clone. (AJCC 8th ed.)


name: Lacrimal Drainage System Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises from the lacrimal sac.


aggressive B-cell non-Hodgkin lymphoma

description: A B-cell non-Hodgkin lymphoma with an aggressive clinical course. This category includes B lymphoblastic lymphoma, subtypes of diffuse large B-cell lymphoma, Burkitt lymphoma, grade 3 follicular lymphoma, and mantle cell lymphoma.


name: Recurrent Intravascular Large B-Cell Lymphoma

description: The reemergence of intravascular large B-cell lymphoma after a period of remission.


name: Mycosis fungoides/Sezary syndrome stage IV

description: Stage IV includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2); IVB (T1-4, N0-3, M1, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative.  M0: No visceral organ involvement.  M1: Visceral involvement (must have pathology confirmation and organ involved should be specified).  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone.  (AJCC 7th ed.)


name: Primary Large B-Cell Lymphoma of Immune-Privileged Site

description: A term that refers to diffuse large B-cell lymphomas that arise as primary tumors in the central nervous system, vitreoretina, and testis in immunocompetent patients.


name: Parotid Gland Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that manifests initially in the parotid gland.


Gastric T-Cell Non-Hodgkin Lymphoma

description: A rare, extranodal T-cell non-Hodgkin lymphoma that arises from the stomach with the bulk of the mass located in the stomach.


B-cell lymphoma recurrent

description: The reemergence of B-cell non-Hodgkin lymphoma after a period of remission.


Advanced Marginal Zone Lymphoma

description: Marginal zone lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: childhood nasal type extranodal NK/T-cell lymphoma

description: A nasal type extranodal NK/T-cell lymphoma occurring in childhood.


name: Advanced Transformed Non-Hodgkin Lymphoma

description: Transformed non-Hodgkin lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Primary Cutaneous Intravascular Large B-Cell Lymphoma

description: Intravascular large B-cell lymphoma that arises from the skin.


B-cell lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Recurrent Peripheral T-Cell Lymphoma, Not Otherwise Specified

description: The reemergence of peripheral T-cell lymphoma, not otherwise specified after a period of remission.


name: Nodal marginal zone B-cell lymphoma recurrent

description: The reemergence of nodal marginal zone lymphoma after a period of remission.


name: Campylobacter Jejuni-Associated Small Intestinal Mucosa-Associated Lymphoid Tissue Lymphoma

description: A mucosa-associated lymphoid tissue lymphoma that arises from the small intestine and it is associated with Campylobacter jejuni infection.


Centroblastic lymphoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Esophageal Mucosa-Associated Lymphoid Tissue Lymphoma

description: An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the esophagus with the bulk of the mass located in the esophagus.


Recurrent Grade 3a Follicular Lymphoma

description: The reemergence of grade 3a follicular lymphoma after a period of remission.


Sporadic Burkitt's lymphoma

description: A clinical variant of Burkitt lymphoma that occurs throughout the world.  It affects both children and adults and is more frequently seen in males.


name: Extranodal marginal zone B-cell lymphoma (MALT type) stage I

description: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage I disease.


name: Lugano Classification Stage I Adult Non-Hodgkin Lymphoma AJCC v8

description: Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


Head and Neck Follicular Lymphoma

description: A follicular lymphoma that arises from the head and neck region. It usually affects older individuals, and the most common sites of involvement are the cervical lymph nodes and Waldeyer ring.


Adult T-cell lymphoma/leukemia stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Primary Pituitary Gland Diffuse Large B-Cell Lymphoma

description: A rare diffuse large B-cell lymphoma that arises from the pituitary gland.


name: Recurrent Childhood Anaplastic Large Cell Lymphoma

description: The reemergence of anaplastic large cell lymphoma in childhood after a period of remission.


name: Precursor B-lymphoblastic lymphoma refractory

description: B-lymphoblastic lymphoma that does not respond to treatment.


name: Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma

description: An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the ocular adnexa. It is the most common type of primary ocular adnexal lymphoma.


Anaplastic large B-cell lymphoma

description: A diffuse large B-cell lymphoma variant characterized by the presence of large round, oval, or polygonal cells with bizarre pleomorphic nuclei resembling Hodgkin or Reed-Sternberg cells. It is unrelated to anaplastic large cell lymphoma which is a T-cell non-Hodgkin lymphoma.


name: Stage III Childhood Lymphoblastic Lymphoma

description: Stage III: Tumors or involved lymph node areas occur on both sides of the diaphragm. Stage III also includes any primary intrathoracic (mediastinal, pleural, or thymic) disease, extensive primary intra-abdominal disease, or any paraspinal or epidural tumors (from PDQ).


Diffuse large B-cell lymphoma recurrent

description: The reemergence of diffuse large B-cell lymphoma after a period of remission.


name: Ann Arbor Stage IV Nodular Lymphocyte Predominant B-Cell Lymphoma


name: Dural Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

description: A rare, primary marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the meningeal dura.  The majority of cases have been described in middle aged women.  Radiologically, the lymphomatous dural infiltration mimics meningioma.


Recurrent Indolent Non-Hodgkin Lymphoma

description: The reemergence of indolent non-Hodgkin lymphoma after a period of remission.


Adult Immunoblastic Lymphoma

description: A morphologic variant of diffuse large B-cell lymphoma occurring in adults.  It is characterized by the presence of large lymphoid cells with abundant cytoplasm and prominent nucleoli.


Stage II Adult Lymphoblastic Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Transformed Small Lymphocytic Lymphoma to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of a small lymphocytic lymphoma to an aggressive diffuse large B-cell lymphoma.


name: B Lymphoblastic Lymphoma by Ann Arbor Stage

description: An anatomic stage for B-lymphoblastic lymphoma based on the Ann Arbor classification criteria.


T-lymphoblastic lymphoma

description: The most frequent type of lymphoblastic lymphoma. It comprises approximately 85-90% of cases. It is more frequently seen in adolescent males. It frequently presents with a mass lesion in the mediastinum. Pleural effusions are common. (WHO, 2001)


intraocular lymphoma

description: A lymphoma that arises within the eye. Signs and symptoms include decreased vision, uveitis, and vitreous floaters.


name: Stage IIIB Mycosis Fungoides and Sezary Syndrome AJCC v7

description: Stage IIIB includes: T4, N0-2, M0, B1. T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


name: Recurrent Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

description: The reemergence of primary diffuse large B-cell lymphoma of the central nervous system after a period of remission.


name: Ann Arbor Stage II Non-Contiguous Aggressive Adult Non-Hodgkin Lymphoma


Childhood Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that occurs during childhood.


Parotid Gland Mantle Cell Lymphoma

description: A mantle cell lymphoma that manifests initially in the parotid gland.


name: Recurrent Childhood Non-Hodgkin Lymphoma

description: The reemergence of non-Hodgkin lymphoma in childhood after a period of remission.


name: Refractory Central Nervous System Non-Hodgkin Lymphoma

description: A central nervous system non-Hodgkin lymphoma which does not respond to treatment.


Stage II Burkitt Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Childhood Peripheral T-Cell Lymphoma, Not Otherwise Specified

description: Peripheral T-cell lymphoma, not otherwise specified, that occurs during childhood.


name: Stage II Childhood Anaplastic Large Cell Lymphoma


Head and Neck Burkitt Lymphoma

description: A Burkitt lymphoma that arises from the head and neck region. In patients with endemic Burkitt lymphoma, the jaws and other facial bones are usually affected. In patients with sporadic Burkitt lymphoma, the gingiva, orbit, and Waldeyer ring are usually affected. In patients with immunodeficiency-related Burkitt lymphoma, the lymph nodes are usually affected.


name: Refractory Primary Vitreoretinal Diffuse Large B-Cell Lymphoma

description: Primary vitreoretinal diffuse large B-cell lymphoma that does not respond to treatment.


name: Refractory Hepatosplenic T-Cell Lymphoma

description: Hepatosplenic T-cell lymphoma that is resistant to treatment.


name: HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: A large B-cell lymphoma characterized by the presence of a diffuse proliferation of large, atypical HHV8-positive neoplastic lymphocytes. It usually arises in association with HHV8-positive multicentric Castleman disease.


name: Transformed Small Lymphocytic Lymphoma to Hodgkin Lymphoma

description: Histologic transformation of small lymphocytic lymphoma to Hodgkin lymphoma.


Childhood Burkitt Lymphoma

description: A Burkitt lymphoma occurring in children.


name: Ann Arbor Stage IV Aggressive Adult Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Burkitt Lymphoma by Ann Arbor Stage

description: An anatomic stage for Burkitt lymphoma based on the Ann Arbor classification criteria.


name: Recurrent Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

description: The reemergence of primary cutaneous diffuse large B-cell lymphoma, leg type after a period of remission.


name: Breast implant-associated anaplastic large cell lymphoma

description: A rare anaplastic large cell lymphoma that develops in individuals with breast implants. It usually presents as an accumulation of seroma fluid between the implant and the surrounding fibrous capsule. The median interval from the time of the implant to the development of lymphoma is approximately 10 years.


Colorectal Non-Hodgkin Lymphoma

description: An extranodal non-Hodgkin lymphoma that arises from the colon or rectum.  The majority are B-cell non-Hodgkin lymphomas.


Esophageal Non-Hodgkin Lymphoma

description: An extranodal non-Hodgkin lymphoma that arises from the esophagus with the bulk of the mass located in the esophagus.  Dysphagia may be the presenting symptom.  The vast majority of cases are diffuse large B-cell lymphomas and B-cell lymphomas of the mucosa-associated lymphoid tissue.


name: Childhood Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

description: An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that occurs during childhood.


name: Extranodal marginal zone B-cell lymphoma (MALT type) recurrent

description: The reemergence of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue after a period of remission.


Intestinal Follicular Lymphoma

description: A follicular lymphoma arising from the intestine.  The majority of cases occur in the small intestine, particularly the duodenum.  Usually the patients have localized disease and a favorable clinical outcome.


name: Burkitt Lymphoma with Plasmacytoid Differentiation

description: Burkitt lymphoma characterized by the presence of malignant cells with eccentric basophilic cytoplasm. The nucleoli of these cells are often single and central. This morphologic variant of Burkitt lymphoma is more often seen in patients with immunodeficiency.


adult T-cell leukemia/lymphoma

description: A peripheral (mature) T-cell neoplasm linked to the human T-cell leukemia virus type 1 (HTLV-1), adult T-cell leukemia/lymphoma is endemic in several regions of the world, in particular Japan, the Caribbean, and parts of Central Africa.


Angiocentric lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: non-Hodgkin's lymphoma of lacrimal gland

description: A non-Hodgkin lymphoma that arises from the lacrimal gland. The majority of cases are of B-cell type. The most common subtypes are mucosa-associated lymphoid tissue lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma.


Burkitt's lymphoma of breast

description: A Burkitt lymphoma that arises from the breast.  It usually affects pregnant or lactating women and presents with bilateral breast involvement and breast swelling.


name: B-cell small lymphocytic lymphoma refractory

description: B-cell small lymphocytic lymphoma that is resistant to treatment.


name: Ann Arbor Stage III Mature T- and NK-Cell Lymphoma


AIDS-Related Anal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma arising from the anus and occurring in HIV-positive patients.  Homosexual HIV-positive men have an increased risk of developing anal non-Hodgkin lymphoma in comparison to the general male population.  The majority of the cases are large cell lymphomas of B-cell phenotype.


name: Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

description: T-cell/histiocyte-rich large B-cell lymphoma that is resistant to treatment.


Prostate Small Lymphocytic Lymphoma

description: A rare small lymphocytic lymphoma that arises from the prostate gland.


Recurrent Childhood Burkitt Lymphoma

description: The reemergence of Burkitt lymphoma in childhood after a period of remission.


name: Nasal Cavity Extranodal NK/T-Cell Lymphoma

description: An extranodal NK/T-cell lymphoma that arises from the nasal cavity.


Pyothorax-Associated Lymphoma

description: An aggressive diffuse large B-cell lymphoma arising in the pleural cavity of patients with a history of long standing pyothorax.  Patients present with chest and back pain, fever, productive cough, dyspnea, and hemoptysis.


name: Ann Arbor Stage I Grade 1 Follicular Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Recurrent Aggressive Non-Hodgkin Lymphoma

description: An aggressive non-Hodgkin lymphoma that has recurred after a period of remission.


name: thyroid gland mucosa-associated lymphoid tissue lymphoma

description: An extranodal marginal zone B-cell lymphoma arising from mucosa-associated lymphoid tissue in the thyroid gland. The vast majority of cases are associated with chronic lymphocytic thyroiditis.


non-Hodgkin's lymphoma of nasal cavity

description: A primary non-Hodgkin lymphoma that affects the nasal cavity and the bulk of the tumor is in this anatomic area.  The majority of the cases are nasal type extranodal NK/T-cell lymphomas and diffuse large B-cell lymphomas.


Adult T-cell lymphoma/leukemia stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Primary Choroidal Non-Hodgkin Lymphoma

description: An indolent, low-grade B-cell non-Hodgkin lymphoma that arises from the choroid. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Lymphoid follicles with germinal centers may be present. In the past these tumors were termed 'reactive lymphoid hyperplasia'. Now they are considered low-grade B-cell lymphomas, most commonly extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.


name: Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

description: The reemergence of T-cell/histiocyte-rich large B-cell lymphoma after a period of remission.


name: Stage II Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

description: A single tumor (extranodal) with regional node involvement or two or more nodal areas on the same side (either above or below) of the diaphragm or two or more single (extranodal) tumors, with or without regional node involvement, on the same side (either above or below) of the diaphragm or a completely resected primary gastrointestinal tract tumor with or without involvement of associated mesenteric nodes only. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Secondary Central Nervous System Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that has spread to the central nervous system following the initial presentation in another nodal or extranodal site.


name: Intestinal T-Cell Lymphoma, Not Otherwise Specified

description: A T-cell lymphoma arising in the intestines, or sometimes other sites in the gastrointestinal tract, that does not conform to either classic enteropathy-associated T-cell lymphoma or monomorphic epitheliotropic intestinal T-cell lymphoma. (WHO 2017)


name: Ann Arbor Stage II Mature T- and NK-Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


name: Primary Cutaneous Peripheral T-Cell Lymphoma, Not Otherwise Specified

description: An exceedingly rare peripheral T-cell lymphoma that arises from the skin and does not meet the criteria that define the other well characterized primary cutaneous peripheral T-cell lymphomas, i.e., it is a diagnosis of exclusion.


name: Primary Cerebral Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises in the cerebrum.


name: diffuse large B-cell lymphoma activated B-cell type

description: A diffuse large B-cell lymphoma that is characterized by the expression of CD44, PKCbeta1, Cyclin D2, BCL-2, and IRF4/MUM1 genes.


Marginal zone lymphoma refractory

description: Marginal zone lymphoma which does not respond to treatment.


Cerebral Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises in the cerebral hemispheres as a primary lesion.


name: Ann Arbor Stage II Contiguous Adult Non-Hodgkin Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: primary cutaneous gamma-delta t-cell lymphoma

description: A primary cutaneous T-cell non-Hodgkin lymphoma that is characterized by the clonal cutaneous proliferation of activated mature gamma-delta T cells with a cytotoxic phenotype.


primary effusion lymphoma

description: Primary effusion lymphoma (PEL) is a large B-cell lymphoma located in the body cavities, characterized by pleural, peritoneal, and pericardial fluid lymphomatous effusions and that is always associated with human herpes virus-8 (HHV-8).


Adult Anaplastic Large Cell Lymphoma

description: An anaplastic large cell lymphoma occurring in adults.


Refractory Primary Effusion Lymphoma

description: Primary effusion lymphoma that is resistant to treatment.


name: Helicobacter Pylori-Related Non-Hodgkin Lymphoma

description: Non-Hodgkin lymphoma that is caused by Helicobacter Pylori.


Refractory Grade 3 Follicular Lymphoma

description: Grade 3 follicular lymphoma that is resistant to treatment.


Early Unfavorable Non-Hodgkin Lymphoma

description: A clinical stage I or II non-Hodgkin lymphoma with at least one of the following risk factors: large mediastinal mass, extranodal spread, elevated erythrocyte sedimentation rate, involvement of at least three lymph node areas, and B symptoms.


Thyroid Non-Hodgkin's Lymphoma

description: A non-Hodgkin lymphoma primarily involving the thyroid gland.  The vast majority of cases are either diffuse large B-cell lymphomas or extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue. Hashimoto (chronic lymphocytic) thyroiditis is almost always present.


Grade 2 Cutaneous Follicular Lymphoma

description: A cutaneous lymphoma which contains 6-15 centroblasts per 40X high-power microscopic field.


name: Refractory HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: HHV8-positive diffuse large B-cell lymphoma, not otherwise specified that is resistant to treatment.


name: Refractory Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation

description: Diffuse large B-cell lymphoma associated with chronic inflammation that is resistant to treatment.


name: Ann Arbor Stage III Grade 1 Follicular Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Fibrin-Associated Diffuse Large B-Cell Lymphoma

description: An unusual form of diffuse large B-cell lymphoma. It is not mass-forming and does not directly produce symptoms, but it is discovered incidentally on histological examination of surgical pathology specimens, excised for various pathologies other than lymphoma. The specimens typically contain fibrinous materials. Single and small aggregates of large lymphoma cells are found in only small foci within the fibrinous or amorphous material. EBV is positive, with type III latency. The clinical outcome is highly favorable, even with surgical excision alone. (WHO 2017)


Mycosis fungoides recurrent

description: The reemergence of mycosis fungoides after a period of remission.


name: Transformed B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of a B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classic Hodgkin lymphoma to an aggressive diffuse large B-cell lymphoma.


name: Anaplastic Large Cell Lymphoma, Sarcomatoid Subtype

description: A are variant of anaplastic large cell lymphoma. It is characterized by presence of large spindle shaped cells resembling a soft tissue sarcoma.


name: Stage IIB Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IIB includes: T3, N0-2, M0, B0,1. T3: One or more tumors (equal or greater than 1 cm in diameter). N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Childhood B Lymphoblastic Lymphoma

description: A B-lymphoblastic lymphoma that occurs during childhood.