interlobulary artery endothelial cell

description: Any endothelial cell that is part of some interlobular artery.


endothelial cell of arteriole

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An endothelial cell that is part of the arteriole.


arcuate vein endothelial cell

description: Any endothelial cell that is part of some kidney arcuate vein.


name: prostate gland microvascular endothelial cell

description: Any microvascular endothelial cell that is part of a prostate gland.


name: kidney outer medulla peritubular capillary cell

description: Any peritubular capillary endothelial cell that is part of some outer renal medulla peritubular capillary.


kidney capillary endothelial cell

description: Any kidney blood vessel cell that is part of some kidney capillary.


endothelial cell of umbilical vein

description: An endothelial cell of the umbilical vein.


retinal blood vessel endothelial cell

description: A blood vessel endothelial cell that is part of the retina.


endothelial cell of artery

description: A blood vessel endothelial cell that is part of an arterial endothelium.


brain microvascular endothelial cell

description: Any microvascular endothelial cell that is part of a brain.


arcuate artery endothelial cell

description: Any endothelial cell that is part of some kidney arcuate artery.


name: placental villus capillary endothelial cell

description: Any capillary endothelial cell that is part of a placenta.


granular cell of epidermis

description: A keratinocyte of the epidermis that is characterized by containing granules of keratohyalin and lamellar granules.


cardiac blood vessel endothelial cell

description: Any blood vessel endothelial cell that is part of some heart.


name: kidney afferent arteriole endothelial cell

description: Any endothelial cell that is part of some renal afferent arteriole.


foreskin keratinocyte

description: Keratinocyte from foreskin.


capillary endothelial cell

description: An endothelial cell found in capillaries.


hindlimb stylopod vein endothelial cell

description: Any vein endothelial cell that is part of a hindlimb stylopod.


inner renal medulla vasa recta cell

description: Any vasa recta cell that is part of some inner renal medulla vasa recta.


onychocyte

description: A differentiated flat keratinocyte that is part of a nail plate. An onychocyte is firmly adherent and does not desquamate.


outer renal medulla vasa recta cell

description: Any vasa recta cell that is part of some outer renal medulla vasa recta.


squamous cell of epidermis

description: A flat keratinocyte immediately below the cornified layer.


endothelial cell of coronary artery

description: Any endothelial cell of artery that is part of a coronary artery.


vasa recta ascending limb cell

description: A cell that is part of some vasa recta ascending limb.


thoracic aorta endothelial cell

description: An endothelial cell that is part of the thoracic endothelium.


dermal microvascular endothelial cell

description: Any microvascular endothelial cell that is part of the dermis.


prickle cell

description: A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin.


vein endothelial cell

description: An endothelial cell that is part of the vein.


suprabasal keratinocyte

description: A keratinocyte of the epidermis suprabasal layer. This cell may express the differentiation markers keratin 10 and keratin 1.


CoA ester of ascr#34


4-O-methyl-L-dopa zwitterion

An aromatic L-alpha-amino acid zwitterion resulting from transfer of a proton from the carboxy to the amino group of 4-O-methyl-L-dopa. Major species at pH 7.3


aromatic L-alpha-amino acid zwitterion

An L-alpha-amino acid zwitterion resulting from a transfer of a proton from the carboxy to the amino group of any aromatic L-alpha-amino acid; major species at pH 7.3.


L-6'-bromotryptophan zwitterion

The L-alpha-amino acid zwitterion that results from the transfer of a proton from the carboxylic acid group to the alpha-amino group of L-6'-bromotryptophan. The major species at pH 7.3.


3-O-methyldopa zwitterion

An aromatic L-alpha-amino acid zwitterion resulting from transfer of a proton from the carboxy to the amino group of 3-O-methyldopa. Major species at pH 7.3


calysolin III

A resin glycoside that is the pentasaccharide derivative of  jalapinolic acid. It has been isolated from Calystegia soldanella.


abiraterone

A 3beta-sterol that is androsta-5,16-dien-3beta-ol substituted at position 17 by a 3-pyridyl group. Administered as the O-acetate, it is used for treatment of metastatic castrate-resistant prostate cancer.


A glucotriose consisting of beta-D-glucopyranosyl, alpha-D-glucopyranosyl and D-glucopyranoseresidues joined in sequence by two (1->4) glycosidic linkages.


name: Metastatic malignant neoplasm to choroid

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A malignant neoplasm that has spread to the choroid from another anatomic site.


brodimoprim

An aminopyrimidine that is 2,4-diaminopyrimidine in which the hydrogen at position 5 has been replaced by a 4-bromo-3,5-dimethoxybenzyl group.


A ceramide phosphoethanolamine zwitterion obtained by transfer of a proton from the phospho to the amino group of any N-acyltetradecasphingosine-1-phosphoethanolamine; major species at pH 7.3.


Gallbladder Soft Tissue Neoplasm

description: A benign, intermediate, or malignant mesenchymal neoplasm that arises from the gallbladder.


2-(2-methylthioethyl)malic acid

The 2-(2-methylthioethyl) derivative of malic acid.


iron trichloride hexahydrate

A hydrate that is the hexahydrate form of iron trichloride.


flufiprole

A racemate comprising equimolar amounts of (R)- and (S)-flufiprole. It is a phenylpyrazole insecticide used to control brown plant hopper and leafy beetle in rice.


lactonamycin

An organic heterohexacyclic compound isolated from the culture broth of Streptomyces rishiriensis. It is an antibiotic with antibacterial activity.


silane

The simplest silane, consisting of a single silicon atom carrying four hydrogens.


Childhood Osteochondroma

description: An osteochondroma that occurs during childhood.


Osteochondromatosis

description: An autosomal dominant neoplastic chondrogenic process affecting multiple sites. It is caused by mutations in the EXT1 or EXT2 genes.  Grossly and microscopically, the lesions resemble an osteochondroma.


Maxillofacial Osteochondroma

description: A rare osteochondroma that arises from a maxillofacial bone.


Childhood Chondroblastoma

description: A chondroblastoma that occurs during childhood.


Maxillofacial Chondroblastoma

description: A benign chondroid-producing neoplasm arising in a maxillofacial bone.


Jaw Chondromyxoid Fibroma

description: A chondromyxoid fibroma that arises from the jaw.


Laryngeal Chondroma

description: A benign neoplasm arising from hyaline cartilage of the larynx. It is characterized by the presence of chondrocytes, a lobulated growth pattern, and calcification.


Maxillofacial Chondroma

description: A benign neoplasm of hyaline cartilage that arises within the medullary cavity of a maxillofacial bone. It is characterized by the presence of chondrocytes, a lobulated growth pattern, and calcification.


Childhood Chondromyxoid Fibroma

description: A chondromyxoid fibroma that occurs during childhood.


Childhood Subungual Exostosis

description: Subungual exostosis that occurs during childhood.


Maxillofacial Chondromyxoid Fibroma

description: An uncommon benign cartilaginous neoplasm arising in a maxillofacial bone. It is characterized by the presence of spindle-shaped or stellate chondrocytes, a lobulated growth pattern, myxoid stroma formation, and sometimes multinucleated giant cells.


Chondromatosis

description: A multifocal benign neoplasm arising from bone or soft tissue.  It is characterized by the presence of chondrocytes and is composed of hyaline cartilage.


name: Bizarre parosteal osteochondromatous proliferation

description: A benign lesion that usually affects the proximal small bones of the hands or feet.  Grossly it consists of a cartilage cap and a bony stalk.  Microscopically it is characterized by the presence of spindle cells, cartilage, and bone, usually in a disorganized pattern compared to subungual exostosis.  Enlarged (bizarre) chondrocytes are present in the cartilage.  Swelling with or without pain is present.  Recurrences following resection have been reported in approximately half of cases.


Solitary Osteochondroma

description: An osteochondroma affecting a single anatomical site.


A 2-aminohexano-6-lactam derived from L-lysine.


A sterol ester that is the O-succinoyl derivative of 3beta-hydroxy-5alpha-pregnan-20-one.


hemisuccinate

A succinate ester in which only one of the carboxy groups of succinic acid has been esterified.


prednisolone succinate

A hemisuccinate resulting from the formal condensation of the 21-hydroxy group prednisolone with one of the carboxy groups of succinic acid. It is used to treat mild to moderate non-infectious eye allergies and inflammation, including damage caused by chemical and thermal burns.


O-succinyl-L-serine

A dicarboxylic acid monoester obtained by formal condensation of one of the carboxy groups of succinic acid with the side-chain hydroxy group of L-serine. It is an intermediate in the biosynthesis of the amino acid cysteine in fungi and bacteria.


cholesteryl hemisuccinate

A dicarboxylic acid monoester resulting from the formal condensation of the hydroxy group of cholesterol with one of the carboxy groups of succinic acid. A detergent that is often used to replace cholesterol in protein crystallography, biochemical studies of proteins, and pharmacology.


6beta-hydroxyprogesterone hemisuccinate

A dicarboxylic acid monoester that is the hydrogen succinate ester of 6beta-hydroxyprogesterone.


A dicarboxylic acid monoester that is the 21-(hydrogen succinate) derivative of 11-deoxycorticosterone.


O-succinyl-L-homoserine

The O-succinyl derivative of L-homoserine.


suxibuzone

A pyrazolidine that is phenylbutazone which is substituted by a 3-carboxypropanoylmethyl group at the 4-position. Suxibuzone is a prodrug for phenylbutazone and is commonly used as an anti-inflammatory drug in horses.


A dicarboxylic acid monoester that is succinic acid monoesterified with 6-endo-amino-6-exo-benzoyl-5-exo-phenylnorbornan-2-ol


O-succinylcarnitine

An O-acylcarnitine having succinyl as the acyl substituent.


monomethyl succinate

A dicarboxylic acid monoester that is succinic acid in which one of the carboxy groups has been converted to its methyl ester.


A sterol ester that is the O-succinoyl derivative of 3beta-hydroxy-5beta-pregnan-20-one.


A steroid ester that is the O-succinoyl derivative of 11alpha-hydroxyprogesterone.


A nucleotide-sugar having ADP as the nucleotide fragment and 2-O-succinyl-D-ribofuranos-5-yl as the sugar component.


hydrocortisone succinate

A derivative of succinic acid in which one of the carboxy groups is esterified by the C-21 hydroxy group of cortisol (hydrocortisone).


etiocholanolone hemisuccinate

A sterol ester that is the O-succinoyl derivative of etiocholanolone.


Tactile Disorder

description: Conditions characterized by an alteration in the ability to perceive touch.


Protein kinase inhibitor of SNF1 analog sensitive allele.


lecithin

A lipid-rich mixture containing glycerol, fatty acids, phosphoric acid and other components.


A member of the class of 2,6-diaminopurines that is 2,6-diamiopurine which is substituted by an isopropyl group at position 9 and in which the amino groups at positions 2 and 6 are substituted by a 1-hydroxybutan-2-yl and 3-(pyridin-2-yl)phenyl groups, respectively (the R enantiomer). A cyclin dependent kinase inhibitor, widely used as its hydrochloride hydrate.


BETHANECHOL CHLORIDE

The chloride salt of bethanechol. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.


(S)-bethanechol chloride

The (S)-enantiomer of bethanechol chloride.


Refractory Lymphoma

description: A lymphoma that does not respond to treatment.


name: Refractory Central Nervous System Lymphoma

description: Central nervous system lymphoma that is resistant to treatment.


Refractory Primary Cutaneous Lymphoma

description: Primary cutaneous lymphoma that does not respond to treatment.


Refractory EBV-Related Lymphoma

description: EBV-related lymphoma that is resistant to treatment.


name: Hodgkin's disease mixed cellularity refractory

description: Mixed cellularity classic Hodgkin lymphoma that is resistant to treatment.


Classical Hodgkin lymphoma refractory

description: Classic Hodgkin lymphoma that is resistant to treatment.


Refractory Primary Bone Lymphoma

description: Primary lymphoma of bone that is resistant to treatment.


Refractory Hodgkin Lymphoma

description: Hodgkin lymphoma resistant to treatment


name: Hodgkin's disease nodular sclerosis refractory

description: Nodular sclerosis classic Hodgkin lymphoma that is resistant to treatment.


name: Refractory Lymphocyte-Rich Classic Hodgkin Lymphoma

description: Lymphocyte-rich classic Hodgkin lymphoma that does not respond to treatment.


name: Hodgkin's disease lymphocyte depletion type refractory

description: Lymphocyte-depleted classic Hodgkin lymphoma that is resistant to treatment.


A potent cell-permeable and bivalent Smac mimetic which binds to XIAP, cIAP-1 and cIAP-2 proteins (Ki = 0.56 nM,  0.31 nM and 1.1 nM, respectively). It induces apoptosis and tumor regression in cancer xenograft models.


A glycol that is 2-methylpropane in which the two hydroxy groups are located at positions 1 and 2..


Sinonasal Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the nasal cavity or paranasal sinuses.


Head and Neck Neuroendocrine Tumor

description: A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the head and neck.


Laryngeal Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm that arises from the larynx.


Sinonasal Neuroendocrine Tumor

description: A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the sinonasal tract.


Head and Neck Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the head and neck.


Paranasal Sinus Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm that arises from the paranasal sinuses.


Paranasal Sinus Neuroendocrine Tumor

description: A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the paranasal sinuses.


Nasal Cavity Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the nasal cavity.


Nasal Cavity Neuroendocrine Tumor

description: A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the nasal cavity.


Laryngeal Neuroendocrine Tumor

description: A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the larynx.


Nasal Cavity Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm that arises from the nasal cavity.


Sinonasal Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm that arises from the nasal cavity or paranasal sinuses.


Head and Neck Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm that arises from the head and neck.


Laryngeal Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the larynx.


A 1,2-diacyl-sn-glycero-3-phosphoethanolamine zwitterion in which the two acyl groups contain a total of 18 carbons and no double bonds.


lucifer yellow carbohydrazide dye

An organic dilithium salt having 6-amino-2-[(hydrazinocarbonyl)amino]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-5,8-disulfonate as the counterion.


nafarelin acetate

An acetate salt obtained by reaction of nafarelin with one equivalent of acetic acid.


An alpha-galactosylceramide in which the nitrogen carries a hexacosanamido group and C-4 carries in addition to a hydroxy function a 4-phenylbutyl group. Essentially a phytosphingosine analogue with a truncated lipid chain terminating in a benzene ring, it has been used in investigations on the binding affinity of glycolipids to CD1d molecules.


The (R,R)-stereoisomer of 2-methyl-6-phytylhydroquinone.


A member of the class of hydroquinones that is 2-methylbenzene-1,4-diol substituted by a phytyl group at position 6.


6-acetamido-3-oxohexanoic acid

A 3-oxo monocarboxylic acid that is 3-oxohexanoic acid substituted at position 6 by an acetamido group.


name: Refractory Bladder Small Cell Neuroendocrine Carcinoma

description: Bladder small cell neuroendocrine carcinoma that is resistant to treatment.


A macromolecule composed of repeating 2,6-dimethyl-1,4-phenyleneoxy units.


name: 18,25-dihydroxyvitamin D3 / 18,25-dihydroxycholecalciferol


vitamin D4

It is present in mushrooms.


dihydrotachysterol

A hydroxy seco-steroid that is 9,10-secoergosta-5,7,22-triene substituted by a hydroxy group at position 3. A synthetic analogue of vitamin D that acts a bone density conservation agent.


name: 1alpha,25-dihydroxy-11alpha-methoxyvitamin D3 / 1alpha,25-dihydroxy-11alpha-methoxycholecalciferol


name: 1alpha,25-dihydroxy-2beta-(6-hydroxyhexyl)vitamin D3 / 1alpha,25-dihydroxy-2beta-(6-hydroxyhexyl)cholecalciferol


name: 1,25-dihydroxy-22-oxavitamin D3 3-hemiglutarate/ 1,25-dihydroxy-22-oxacholecalciferol 3-hemiglutarate


name: (6R)-vitamin D2 6,19-sulfur dioxide adduct / (6R)-ergocalciferol 6,19-sulfur dioxide adduct


previtamin D3

A hydroxy seco-steroid which is an intermediate in the production of vitamin D3 in human skin.


23(S),25-dihydroxy-24-oxovitamin D3

A hydroxycalciol that is 25-hydroxyvitamin D3 carrying an additional hydroxy group at position 23 (with 23S-configuration) and an oxo group at position 24. An intermediate in the degradation pathway of 25-OH-vitamin D3.


name: 24-(dimethoxyphosphoryl)-25,26,27-trinorvitamin D3 / 24-(dimethoxyphosphoryl)-25,26,27-trinorcholecalciferol


name: 24-fluoro-25-hydroxyvitamin D3 / 24-fluoro-25-hydroxycholecalciferol


(20S,24S)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 and 24 (both with S-configuration).


name: 2alpha-chloro-1beta,25-dihydroxyvitamin D3 / 2alpha-chloro-1beta,25-dihydroxycholecalciferol


name: (20S)-1alpha,20,25-trihydroxy-24a-homovitamin D3 / (20S)-1alpha,20,25-trihydroxy-24a-homocholecalciferol


name: (6R)-vitamin D3 6,19-(4-phenyl-1,2,4-triazoline-3,5-dione) adduct


name: (24R)-6,19-epidioxy-1,24-dihydroxy-6,19-dihydrovitamin D3 / (24R)-6,19-epidioxy-1,24-di hydroxy-6,19-dihydrocholecalciferol


name: 1alpha,25-dihydroxy-24-oxo-23-azavitamin D2 / 1alpha,25-dihydroxy-24-oxo-23-azaergocalciferol


name: (24R,25S)-25,26-epoxy-1alpha,24-dihydroxyvitamin D3 / (24R,25S)-25,26-epoxy-1alpha,24-dihydroxycholecalciferol


name: (23R)-1alpha,23,25-trihydroxy-23-methylvitamin D3 / (23R)-1alpha,23,25-trihydroxy-23-methylcholecalciferol


name: 25-hydroxy-16,17-didehydrovitamin D3 / 25-hydroxy-16,17-didehydrocholecalciferol


name: 1alpha,25-dihydroxy-18-oxovitamin D3 / 1alpha,25-dihydroxy-18-oxocholecalciferol


calcidiol 3-O-(beta-D-glucuronide)

A steroid glucosiduronic acid that is calcidiol in which the hydroxy hydrogen at position 3 has been replaced by a beta-D-glucuronyl residue.


name: 1alpha,25-dihydroxy-11alpha-(hydroxymethyl)vitamin D3 / 1alpha,25-dihydroxy-11alpha-(hydroxymethyl)cholecalciferol


name: 1alpha,24,25,28-tetrahydroxyvitamin D2 / 1alpha,24,25,28-tetrahydroxyergocalciferol


name: 1alpha,25-dihydroxy-(26,26)-(27,27)-diethanovitamin D3 / 1alpha,25-dihydroxy-(26,26)-(27,27)-diethanocholecalciferol


1,24(S)-dihydroxyvitamin D2

Metabolite of vitamin D2. It  present in the circulation of humans, cows, and rats given pharmacologic doses of vitamin D2


A hydroxycalciol that is a synthetic analogue of vitamin D3 which contains an oxolane ring and exhibits weak vitamin D receptor agonist activity.


(20S)-hydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying an additional hydroxy group at position 20 with S-configuration.


18-acetoxy-1alpha-hydroxyvitamin D3

A hydroxycalciol that is calciol with an additional hydroxy group at position C-1 and an acetoxy group at C-18.


name: 1alpha,25-dihydroxy-24a,24b-dihomo-23-oxavitamin D3 / 1alpha,25-dihydroxy-24a,24b-dihomo-23-oxacholecalciferol


ergocalciferol

A vitamin D supplement and has been isolated from alfalfa.


(20S,23)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration) and 23.


name: (25R)-26,26,26-trifluoro-1alpha,25-dihydroxyvitamin D3 / (25R)-26,26,26-trifluoro-1alpha,25-dihydroxycholecalciferol


name: 1alpha-Hydroxy-25,26,27-trinorvitamin D3 24-carboxylic acid


name: 1alpha,25-dihydroxy-20-epivitamin D2 / 1alpha,25-dihydroxy-20-epiergocalciferol


name: (23Z)-25-hydroxy-16,17,23,24-tetradehydrovitamin D3 / (23Z)-25-hydroxy-16,17,23,24-tetradehydrocholecalciferol


name: (23S,25R)-25-hydroxyvitamin D3 26,23-lactol / (23S,25R)-25-hydroxycholecalciferol 26,23-lactol


vitamin D5

A vitamin D in which the side-chain at position 17 consists of a (5R)-5-ethyl-6-methylheptan-2-yl group.


name: (10e)-19-(3-carboxylpropyl)vitamin d3 / (10e)-19-(3-carboxylpropyl)cholecalciferol


name: (20S)-1alpha,25-dihydroxy-20-methoxyvitamin D3 / (20S)-1alpha,25-dihydroxy-20-methoxycholecalciferol


name: 1alpha,25-dihydroxy-24a,24b-dihomo-22-oxavitamin D3 / 1alpha,25-dihydroxy-24a,24b-dihomo-22-oxacholecalciferol


name: (24R)-1alpha,24,25,26-tetrahydroxyvitamin D2 / (24R)-1alpha,24,25,26-tetrahydroxyergocalciferol


name: (24S,25S)-25,26-epoxy-1alpha,24-dihydroxyvitamin D3 / (24S,25S)-25,26-epoxy-1alpha,24-dihydroxycholecalciferol


name: 23,23-difluoro-1alpha,25-dihydroxyvitamin D3 / 23,23-difluoro-1alpha,25-dihydroxycholecalciferol


name: 1alpha,25-dihydroxy-24a-homo-22-thiavitamin D3 / 1alpha,25-dihydroxy-24a-homo-22-thiacholecalciferol


name: 1alpha,25-Dihydroxyvitamin D3 25-trimethylsilyl ether


name: (24S,25R)-25,26-epoxy-1alpha,24-dihydroxyvitamin D3 / (24S,25R)-25,26-epoxy-1alpha,24-dihydroxycholecalciferol


1alpha,2beta,25-trihydroxy vitamin D3

A hydroxy seco-steroid that is calciol carrying three additional hydroxy substituents at positions 1alpha, 2beta and 25.


A hydroxycalciol that is a synthetic analogue of vitamin D3 which contains an oxolane ring and exhibits weak vitamin D receptor agonist activity


D3 vitamins

A vitamin D that is calciol or its hydroxylated metabolites calcidiol and calcitriol. Calciol (also known as vitamin D3) acts as a hormone precursor, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.


A hydroxycalciol that is calcitriol with an acetoxy group at C-18.


name: 1alpha,25-dihydroxy-24-nor-22-oxavitamin D3 / 1alpha,25-dihydroxy-24-nor-22-oxacholecalciferol


A hydroxycalciol that is vitamin D2 in which the hydrogen at position 25 has been replaced by a hydroxy group.


5,6-trans-vitamin D3

A member of the class of D3 vitamins that is calciol in which the double bond at position 5 adopts a trans-configuration. During exposure to sunlight, previtamin D3 and vitamin D3 in the skin become photoisomerized to 5,6-trans-vitamin D3.


tacalcitol

A hydroxy seco-steroid that is calciol which carries hydroxy groups at positions 1S and 24R. It is a vitamin D3 analog which is used for the treatment of psoriasis vulgaris in adults, especially on the scalp.


alfacalcidol

A member of the class of D3 vitamins that is calciol in which the hydrogen at the 1alpha position is replaced by a hydroxy group. It is an active metabolite of cholecalciferol, which performs important functions in regulation of the calcium balance and the bone metabolism.


(20S,24R)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 (with S-configuration) and 24 (with R-configuration).


20(S),25-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration) and 25.


doxercalciferol

A hydroxy seco-steroid and synthetic vitamin D2 analogue that undergoes metabolic activation in vivo to form 1alpha,25-dihydroxyvitamin D2 (1alpha,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. It is used to treat secondary hyperparathyroidism, a condition in which the body produces excess parathyroid hormone (PTH; a natural substance needed to control the amount of calcium in the blood) in certain people with chronic kidney disease.


ERCALCITRIOL

A hydroxycalciol that is vitamin D2 bearing additional hydroxy substituents at positions 1alpha and 25.


name: 26,26,26-trifluoro-25-hydroxyvitamin D3 / 26,26,26-trifluoro-25-hydroxycholecalciferol


calcidiol 25-O-(beta-D-glucuronide)

A steroid glucosiduronic acid that is calcidiol in which the hydroxy hydrogen at position 25 has been replaced by a beta-D-glucuronyl residue.


name: 1alpha,25-dihydroxy-11beta-methoxyvitamin D3 / 1alpha,25-dihydroxy-11beta-methoxycholecalciferol


name: (24R,25R)-25,26-epoxy-1alpha,24-dihydroxyvitamin D3 / (24R,25R)-25,26-epoxy-1alpha,24-dihydroxycholecalciferol


vinflunine

An organic heteropentacyclic compound and an organic heterotetracyclic compound that is vinorelbine in which the  tetrahydropyridine moiety of the heterotetracyclic part of the molecule has been redced to the corresponding piperidine, and in which the ethyl group attached to this ring has been replaced by a 1,1-difluoroethyl group.


His-Val

A dipeptide formed from L-histidine and L-valine residues.


A 6-alkyl-4-hydroxy-2H-pyran-2-one that is 4-hydroxy-2H-pyran-2-one in which the hydrogen at position 6 is replaced by an 11-methyldodecyl group.


Any member of the class of 2-pyranones that is 4-hydroxy-2H-pyran-2-one in which the hydrogen at position 6 has been replaced by an alkyl group.


A 6-alkyl-4-hydroxy-2H-pyran-2-one that is 4-hydroxy-2H-pyran-2-one in which the hydrogen at position 6 is replaced by an 11-hydroxyheptadecyl group.


A 6-alkyl-4-hydroxy-2H-pyran-2-one that is 4-hydroxy-2H-pyran-2-one in which the hydrogen at position 6 is replaced by a 2-methyldecyl group.


A 6-alkyl-4-hydroxy-2H-pyran-2-one that is 4-hydroxy-2H-pyran-2-one in which the hydrogen at position 6 is replaced by a 2-hydroxytridecyl group.


A 6-alkyl-4-hydroxy-2H-pyran-2-one that is 4-hydroxy-2H-pyran-2-one in which the hydrogen at position 6 is replaced by a 15-hydroxypentadecyl group.


A 6-alkyl-4-hydroxy-2H-pyran-2-one that is 4-hydroxy-2H-pyran-2-one in which the hydrogen at position 6 is replaced by a non-8-en-1-yl group.


A 6-alkyl-4-hydroxy-2H-pyran-2-one that is 4-hydroxy-2H-pyran-2-one in which the hydrogen at position 6 is replaced by a hexadecan-2-yl group.


A 6-alkyl-4-hydroxy-2H-pyran-2-one that is 4-hydroxy-2H-pyran-2-one in which the hydrogen at position 6 is replaced by a 14-hydroxytetradecyl group.


A 6-alkyl-4-hydroxy-2H-pyran-2-one that is 4-hydroxy-2H-pyran-2-one in which the hydrogen at position 6 is replaced by an 11-methylheptadecyl group.


Splenic Plasmacytoma

description: A plasmacytoma that arises in the spleen.


name: Splenic B-Cell Lymphoma/Leukemia, Unclassifiable

description: A small B-cell clonal lymphoproliferative disorder of the spleen that does not fall into any of the other categories of mature B-cell neoplasms.


Malignant Splenic Soft Tissue Neoplasm

description: A malignant mesenchymal neoplasm that arises from the spleen.


Recurrent Hairy Cell Leukemia Variant

description: The reemergence of hairy cell leukemia variant after a period of remission.


name: Splenic Manifestation of Chronic Myeloid Leukemia, BCR-ABL1 Positive

description: Infiltration and expansion of the red pulp and sinusoids of the spleen by chronic myeloid leukemia, BCR-ABL1 positive.


name: Splenic Manifestation of B-Cell Prolymphocytic Leukemia

description: Infiltration and expansion of the white and red pulp of the spleen by B-cell prolymphocytic leukemia.


name: Extramedullary Disease in Multiple Myeloma Involving the Spleen

description: Infiltration of the spleen by malignant (clonal) plasma cells in patients with history of multiple myeloma


name: Sclerosing angiomatoid nodular transformation of spleen

description: A benign, circumscribed lesion that arises from the spleen and is composed of multiple angiomatoid nodules in a fibrosclerotic stroma. It most often affects middle-aged females. It is usually asymptomatic, and most cases are detected incidentally on imaging studies.


name: Splenic Manifestation of T-Cell Prolymphocytic Leukemia

description: Infiltration and expansion of the white and red pulp of the spleen by T-cell prolymphocytic leukemia.


Malignant lymphoma of spleen

description: A non-Hodgkin lymphoma or rarely Hodgkin lymphoma that arises from the spleen.


name: Splenic Manifestation of T-Cell Large Granular Lymphocyte Leukemia

description: Infiltration and expansion of the red pulp cords and sinusoids of the spleen by T-cell large granular lymphocyte leukemia. The white pulp of the spleen is not involved and is often hyperplastic.


LATRUNCULIN A

A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes.


thiacloprid-amide

A monochloropyridine that is 2-chloropyridine substituted by a [2-(carbamoylimino)-1,3-thiazolidin-3-yl]methyl group at position 5. It is a metabolite of the insecticide thiacloprid.


A member of the class of thiazolidinones that is 3-[(dimethylamino)methyl]-1,3-thiazolidine-2,4-dione bearing an additional (4-methoxyphenyl)methylidene substituent at position 5.


name: 3-[4-oxo-5-(phenylmethylene)-2-sulfanylidene-3-thiazolidinyl]propanoic acid butyl ester


A thiazolidinone that is 1,2-thiazolidin-3-one bearing an amino substituent at position 4.


optovin

A member of the class of thiazolidinone that is rhodanine in which the two methylene hydrogens have been replaced by a 2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl]methylidene group. A TRPA1 ligand that can be reversibly photoactivated.


pyochelin

A member of the class of thiazolidines that is (4R)-3-methyl-1,3-thiazolidine-4-carboxylic acid which is substituted at position 2 by a (4R)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazol-4-yl group. A siderophore that is produced by Pseudomonas aeruginosa (via condensation of salicylic acid and two molecules of cysteine) as a mixture of two easily interconvertible diastereoisomers, pyochelin I (major) and pyochelin II (minor). The enantiomeric compounds, enant-pyochelin, are produced by Pseudomonas fluorescens.


A thiazolidinone that is 2-thioxo-4-thiazolidinone which is substituted at position 3 by a (m--trifluoromethyl)phenyl group and at position 5 by a p-carboxybenzylidene group. It is an inhibitor of cystic fibrosis transmembrane conductance regulator, a membrane protein and chloride channel in vertebrates that is encoded by the CFTR gene.


A member of the class of oxindoles that is 5-chloro-oxindole in which the methylene hydrogens at position 3 have been replaced by an N-(2-carboxyethyl)rhodanin-5-ylidene group.


YERSINIABACTIN

A member of the class of thiazolidines that is (4S)-4-methyl-4,5-dihydro-1,3-thiazole-4-carboxylic acid which is substituted at position 2 by a (1S)-1-hydroxy-1-{(4R)-2-[(4R)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazol-4-yl]-1,3-thiazolidin-4-yl}-2-methylpropan-2-yl group. A siderophore found in the gram-negative bacterium species, Yersinia enterocolitica and Yersinia pestis.


flutianil

A member of the class of thiazolidines that is N-(o-methoxyphenyl)thiazolidine which is substituted at position 2 by a methylene group, the hydrogens of which are replaced by cyano and [2-fluoro-5-(trifluoromethyl)phenyl]sulfanediyl groups; the double bond conjugated to the cyano group has Z configuration. A fungicide intended for use on horticultural crops including strawberries and grapevines.


A member of the class of thiazolidinones that is 2-sulfanylidene-1,3-thiazolidin-4-one in which the hydrogens at positions 3 and 5 are replaced by carboxymethyl and 3-(1-phenylethoxy)-4-(2-phenylethoxy)benzylidene groups, respectively. It is an inhibitor of protein mannosyl transferase 1 (PMT1) and blocks protein O-mannosylation.


pioglitazone

A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.


A thiazolidinone that is the 5-{[4-(pyridin-4-yl)quinolin-6-yl]methylene} derivative of 1,3-thiazolidine-2,4-dione. A PI3K inhibitor


THIAZOLIDINEDIONE

A thiazolidenedione carrying oxo substituents at positions 2 and 4.


pyochelin II

A pyochelin that has S-stereochemistry at the thioaminal centre; the diastereoisomer with R-stereochemistry at this centre is pyochelin I. Pseudomonas aeruginosa produces a mixture of pyochelin I (major) and pyochelin I (minor) via condensation of salicylic acid and two molecules of cysteine. The enantiomeric compounds, enant-pyochelin I and II, are produced by Pseudomonas fluorescens.


ciglitazone

An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.


1,3-Thiazolidine substituted with methyl groups at C-2, -5 and -5 and with a carboxy group at C-4, representing the thiazolidine ring of a generalised penicillin structure.


LERIGLITAZONE

A member of the class of thiazolidenediones that is the hydroxy derivative of pioglitazone.


A trimethyl-substituted thiazolidine carboxylic acid derived by cleavage of and loss of C=O from the azetidine ring of penicillanic acid.


A  thiazolidinecarboxamide that is 1,3-thiazolidine-2-carboxamide substituted by a methyl group at position 2.


pyochelin I

A pyochelin that has R-stereochemistry at the thioaminal centre; the diastereoisomer with S-stereochemistry at this centre is pyochelin II. Pseudomonas aeruginosa produces a mixture of pyochelin I (major) and pyochelin II (minor) via condensation of salicylic acid and two molecules of cysteine. The enantiomeric compounds, enant-pyochelin I and II, are produced by Pseudomonas fluorescens.


LATRUNCULIN B

A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica.


lugdunin

A thiazolidine-containing homodetic cyclic peptide that is isolated from human nasal bacteria. Exhibits bactericidal activity against many major pathogens including methicillin-resistant Staphylococcus aureus (MRSA).


THIACLOPRID

The (Z)-stereoisomer of thiacloprid.


thiazolidinediones

A thiadiazolidine in which the 1,3-thiazolidine ring is substituted by two oxo groups.


benzylpenicilloic acid

A penicilloic acid where the side-chain N-acyl group is specified as phenylacetyl.


benzylpenicilloyl-cysteine

A compound obtained from nucleophilic cleavage of the beta-lactam ring of benzylpenicillin by the amino group of L-cysteine.


A thiazolidinone that is 2-sulfanylidene-1,3-thiazolidin-4-one substituted by 3-{[3-(morpholin-4-yl)propyl]amino}-3-oxopropyl and 4-ethylbenzylidene groups at positions 3 and 5, respectively. It is a ferroptosis inducer.


rhodanine 3-acetic acid derivative

Any thiazolidinone that is derived from rhodanine 3-acetic acid.


A member of the class of thiazolidinones that is 2-sulfanylidene-1,3-thiazolidin-4-one which is substituted at position 5 by a (4-ethylphenyl)methylidene group. It is a cell permeable inhibitor of c-Myc-Max dimerization and exhibits antitumour effects in vivo. It downregulates c-Myc expression and upregulates CDK inhibitors, p21 and p27 resulting in the inhibition of proliferation, induction of apoptosis and cell cycle arrest in G0/G1 phase.


thiacloprid

A  nitrile that is cyanamide in which the hydrogens are replaced by a 1,3-thiazolidin-2-ylidene group which in turn is substituted by a (6-chloropyridin-3-yl)methyl group at the ring nitrogen.


penicilloic acid

A thiazolidinedicarboxylic acid obtained via hydrolysis of the beta-lactam ring of a penicillin.


A member of the class of thiazolidinones that is 1,1-dioxo-2,3-diphenyl-1,3-thiazolidin-4-one bearing an additional (4-methoxyphenyl)methylidene substituent at position 5.


epalrestat

A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.


Paratesticular Paraganglioma

description: An extremely rare paraganglioma that arises from the paratesticular structures.


name: Hematologic Neoplasm with Germline Predisposition Associated with a Constitutional Disorder Affecting Multiple Organ Systems

description: Familial hematologic neoplasms associated with germline mutations and a preexisting disorder or organ dysfunction other than a platelet disorder.


name: Hematologic Neoplasm with Germline Predisposition Associated with Inherited Bone Marrow Failure Syndrome

description: Familial myelodysplastic syndromes/ acute myeloid leukemias associated with inherited bone marrow failure syndromes.


name: Hematologic Neoplasm with Germline GATA2 Mutation

description: Myelodysplastic syndromes/acute myeloid leukemias associated with germline GATA2 mutation.


name: Hematologic Neoplasm with Germline SAMD9 Mutation

description: Myelodysplastic syndromes/acute myeloid leukemias associated with germline SAMD9 mutation.


name: Hematologic Neoplasm with Germline SAMD9L Mutation

description: Myelodysplastic syndromes/acute myeloid leukemias associated with germline SAMD9L mutation.


name: Juvenile Myelomonocytic Leukemia Associated with Neurofibromatosis

description: Juvenile myelomonocytic leukemia that is associated with neurofibromatosis type 1 (NF1).


name: Juvenile Myelomonocytic Leukemia Associated with Noonan Syndrome-Like Disorder

description: Juvenile myelomonocytic leukemia that is associated with a genetic disorder caused by germline mutations in the CBL gene and phenotypically resembles Noonan syndrome (Noonan syndrome-like disorder).


name: Hematologic Neoplasm Associated with Down Syndrome

description: Hematologic neoplasms occurring in individuals with Down syndrome.  There is an increased risk of acute leukemias in both children and adults with Down syndrome.  In particular, the incidence of acute myeloid leukemia in Down syndrome children of less than five years of age is particularly high, it is usually an acute megakaryoblastic leukemia, and is associated with GATA1 gene mutation.  This group of disorders also includes the entity transient abnormal myelopoiesis which occurs in neonates and is associated with GATA1 gene mutation.


name: Hematologic Neoplasm with Germline Predisposition Associated with Telomerase Biology Disorder

description: Familial myelodysplastic syndromes/ acute myeloid leukemias associated with telomerase biology disorders.


Serous Tubal Intraepithelial Lesion

description: A non-invasive, precursor epithelial proliferation that arises from the fallopian tube, lacks severe atypia, and demonstrates serous differentiation.


name: 4-[[3-oxo-2-(3-pyridinyl)-1H-isoindol-1-yl]amino]benzoic acid ethyl ester


N-OXALYLGLYCINE

An amino dicarboxylic acid that is iminodiacetic acid with an oxo substituent. It is used as an inhibitor of alpha-ketoglutarate dependent (EC 1.14.11.*) enzymes.


inulin

An inulobiose in which the anomeric centre has beta-configuration.


An alkatriene consisting of 4,8-dimethylnonane having the three double bonds in the 1-, 3- and 7-positions.


novobiocin

A coumarin-derived antibiotic obtained from Streptomyces niveus.


O-linoleyl-L-carnitine

An O-octadecadienoyl-L-carnitine where the acyl group specified is linoleyl.


A L-tyrosine derivative that is L-dopa in which the hydroxy groups at positions 3 and 4 of the phenyl ring are replaced by methoxy groups.


A mononitroglycerol that is glycerol in which the hydrogen atom of the hydroxy group at position 1 is replaced by a nitro group.


Parotid Gland Lymphangioma

description: A lymphangioma arising from the parotid gland.


PENTAMETHONIUM BROMIDE

The bromide salt of pentamethonium. It is a ganglion blocker and exhibits antihypertensive activity.


boryl group

A univalent group of formula BRR' (where R or R' can be H) with the free valency at the boron atom.


A member of the class of  thiadiazoles  that is 1,3,4-thiadiazole substituted by pyrazin-2-yl and (2,6-dichlorobenzyl)sulfanediyl groups at positions 2 and 5, respectively. It is a selective activator of mechanosensitive channel piezo1.


dichlorobenzene

Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.


avilamycin A precursor

An oligosaccharide derivative that is produced by Streptomyces viridochromogenes and is an epimeric intermediate in the biosynthesis of avilamycin A.


TEFLUBENZURON

A N-acylurea that is N-carbamoyl-2,6-difluorobenzamide substituted by a 3,5-dichloro-2,4-difluorophenyl group at the terminal nitrogen atom.


triclocarban

A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.


(S)-vinclozolin

A 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione that is the (S)-enantiomer of vinclozolin.


VINCLOZOLIN

A member of the class of oxazolidinones that is 5-ethenyl-5-methyl-2,4-oxazolidinedione in which the imide hydrogen is replaced by a 3,5-dichlorophenyl group.


(R)-piperalin

A 3-(2-methylpiperidin-1-yl)propyl 3,4-dichlorobenzoate that has R configuration.


ISOCONAZOLE

A member of the class of imidazoles that carries a 2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl group at position 1.


(S)-fenticonazole

A 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole that is the (S)-enantiomer of fenticonazole.


PENCONAZOLE

A racemate comprising equal amounts of (R)- and (S)-penconazole. A fungicide used to control powdery mildew, scab and other pathogenic Ascomycetes, Basidiomycetes and Deuteromycetes.


An organochlorine compound that is the 3'-hydroxylated metabolite of diclofenac.


A member of the class of isoxazoles that is 4,5-dihydro-1,2-oxazole substituted by 4-[(2-ethyl-3-oxo-1,2-oxazolidin-4-yl)carbamoyl]-3-methylphenyl, trifluoromethyl, and 3,5-dichloro-4-fluorophenyl groups at positions 3, 5, and 5, respectively.


DICLOFOP-METHYL

A methyl ester resulting from the formal condensation of the carboxylic acid group of 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoic acid with methanol.


(S)-piperalin

A 3-(2-methylpiperidin-1-yl)propyl 3,4-dichlorobenzoate that has S configuration.


3,6 DICHLOROMETHOXYBENZOIC ACID

A methoxybenzoic acid that is O-methylsalicylic acid substituted by chloro groups at positions 3 and 6.


The (4S,5S)-stereoisomer of isocycloseram.


FENHEXAMID

An aromatic amide resulting from the formal condensation of the carboxy group of 1-methylcyclohexanecarboxylic acid with the amino group of 4-amino-2,3-dichlorophenol.


A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.


A monocarboxylic acid that is cyclopropanecarboxylic acid substituted by methyl groups at positions 1 and 2 and a 3,5-dichlorophenylcarbamoyl group at position 2.


A trichlorobiphenyl that is 1,4-dichlorobenzene in which one of the hydrogens has been replaced by a 3-chlorophenyl group.


dichlorobenzoyl-CoA

Any  chlorobenzoyl-CoA having dichlorobenzoyl as the aroyl substituent.


SULFENTRAZONE

A member of the class of triazoles that is 5-oxo-1,2,4-triazole which is substituted at positions 1, 3, and 4 by 2,4-dichloro-5-[(methylsulfonyl)amino]phenyl, methyl, and difluoromethyl groups, respectively. A protoporphyrinogen oxidase inhibitor, it is used as a herbicide to control broad-leaved weeds in soya and tobacco crops. Not approved for use within the European Union.


A phenylurea that is urea substituted by 4-chloro-2-hydroxyphenyl and 3,4-dichlorophenyl groups at positions 1 and 3 respectively. A metabolite of triclocarban.


FLUQUINCONAZOLE

A member of the class of quinazolines that is 6-fluoroquinazolin-4-one carrying additional 1,2,4-triazol-1-yl and 2,4-dichlorophenyl substituents at positions 2 and 3 respectively. A fungicide used to control Ascomycetes, Deuteromycetes and Basidiomycetes spp. on cereals, beets and fruit.


PROPICONAZOLE

The cyclic ketal obtained by formal condensation of 1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone with pentane-1,2-diol. A triazole fungicide, it is used commercially as a diastereoisomeric mixture on soft fruit (including apricots, peaches, nectarines, plums and prunes), nuts (including peanuts, pecans and almonds), mushrooms, and grasses grown for seeds.


A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-cyano-3,3-dimethylbutanoic acid with the amino group of 1-(2,4-dichlorophenyl)ethylamine.


dichlorocatechol

A chlorocatechol carrying two chloro groups at unspecified positions.


(S)-flufiprole

A 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-[(2-methylprop-2-en-1-yl)amino]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile that has S configuration at the sulfoxide.


A member of the class of  benzamides that is benzamide substituted by chloro groups at positions 2 and 6.


GAMENDAZOLE

A member of the class of indazoles that is 3-(indazol-3-yl}prop-2-enoic acid carrying additional 2,4-dichlorobenzyl and trifluoromethyl substituents at positions 1 and 6 respectively. An orally active antispermatogenic compound with antifertility effects that is a potential male contraceptive drug.


A member of the class of  benzamides that is obtained by the formal condensation of  2,4-dichlorobenzoic acid and  benzotriazole. It acts as an inhibitor for tubulin acetylation mediated by trichostatin A.


(S)-fipronil

A 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile that has S configuration at the sulfoxide.


An organochlorine compound that is a metabolite of diclofenac having hydroxy and methoxy groups at positions 3' and 4' respectively..


diclofenac beta-D-glucosiduronic acid

A beta-D-glucosiduronic acid (beta-D-glucuronide) that is a metabolite of diclofenac.


laduviglusib

A member of the class of aminopyrimidines that is 2-aminopyrimidine substituted at positions N2, 5 and 6 by (5-cyanopyridin-2-yl)ethyl, 4-methylimidazol-2-yl and 2,4-dichlorophenyl groups respectively.


RAC-DICHLORPROP

An aromatic ether that is 2-hydroxypropanoic acid in which the hydroxy group at position 2 has been converted to its 2,4-dichlorophenyl ether.


CHLOZOLINATE

A racemate comprising equimolar amounts of (R)- and (S)-chlozolinate. An obsolete fungicide, formerly used as a foliar spray against Botrytis, Sclerotinia and Monilia spp.


dichlorobenzyl alcohol

A member of the class of benzyl alcohols that is benzyl alcohol in which the hydrogens at positions 2 and 4 are replaced by chlorines.


(S)-DICHLORPROP

The S- (inactive) enantiomer of dichlorprop.


(S)-chlozolinate

An ethyl 3-(3,5-dichlorophenyl)-5-methyl-2,4-dioxo-1,3-oxazolidine-5-carboxylate that is the (S)-enantiomer of chlozolinate.


(R)-fipronil

A 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile that has R configuration at the sulfoxide.


(S)-econazole

A 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of econazole.


A dichlorocatechol that is catechol in which the hydrogens at positions 3 and 4 are replaced by chlorines.


An alanine derivative that is methyl 3-[2-(2,6-dichlorophenyl)quinolin-6-yl]alaninate in which one of the hydrogens attached to the primary amino group is replaced by a 2,6-dichlorobenzyl group.


The (4R,5S)-stereoisomer of isocycloseram.


(R)-zoxamide

A 3,5-dichloro-N-(1-chloro-3-methyl-2-oxopentan-3-yl)-4-methylbenzamide that is the (R)-enantiomer of zoxamide.


AZACONAZOLE

A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2,4-dichlorophenyl and 1,2,4-triazol-1-ylmethyl groups. A fungicide used mainly in ornamental crops to control canker and other diseases. Azaconazole is moderately toxic to mammals but is not expected to bioaccumulate. It is moderately toxic to birds, fish and aquatic invertebrates.


(S)-zoxamide

A 3,5-dichloro-N-(1-chloro-3-methyl-2-oxopentan-3-yl)-4-methylbenzamide that is the (S)-enantiomer of zoxamide.


A member of the class of ureas that is  1-methylurea substituted by a hydroxy group at position 1 and a 3,4-dichlorophenyl group at position 3.


2,4-DICHLOROPHENOXYACETIC ACID

A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.


bixlozone

An isoxazolidinone that is 1,2-oxazolidin-3-one substituted by a 2,4-dichlorobenzyl group at position 2 and two methyl groups at position 4. It is a herbicide used for the control of annual ryegrass (including herbicide resistant biotypes) and regionally specific broadleaf weeds.


procymidone

An azabicycloalkane that is 1,5-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione in which the amino hydrogen is replaced by a 3,5-dichlorophenyl group. A fungicide widely used in horticulture as a seed dressing, pre-harvest spray or post-harvest dip for the control of various diseases.


A non-proteinogenic amino acid derivative that is methyl alaninate substituted by a tert-butoxycarbonyl group the primary amino group and by a 2-(2,6-dichlorophenyl)-6-quinolyl group at position 3.


A phenylurea that is urea substituted by 4-chloro-2-sulfooxyphenyl and 3,4-dichlorophenyl groups at positions 1 and 3 respectively. A metabolite of triclocarban.


(S)-mefenpyr

A 1-(2,4-dichlorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-3,5-dicarboxylic acid that has S configuration.


The stereoisomer of 2-cyano-N-[1-(2,4-dichlorophenyl)ethyl]-3,3-dimethylbutanamide obtained by formal condensation of the carboxy group of (S)-2-cyano-3,3-dimethylbutanoic acid with the amino group of (R)-1-(2,4-dichlorophenyl)ethylamine.


PROTHIOFOS

An organic thiophosphate that is the 2,4-dichlorophenyl ester of O-ethyl S-propyl dithiophosphoric acid.


(S)-leptophos

The (S)-enantiomer of leptophos.


A member of the class of imines that is 2,3-dihydro-1,4-naphthoquinone imine in which the imine hydrogen has been replaced by a 3,5-dichloro-4-hydroxyphenyl group.


(S)-butoconazole

The (S)-enantiomer of butoconazole.


apraclonidine

An imidazoline that is 2-amino 4,5-dihydro-1H-imidazoline in which one of the exocyclic amino hydrogens has been replaced by a 4-amino-2,6-dichlorophenyl group.


A dichlorobiphenyl that is 1,3-dichlorobenzene in which the hydrogen at position 2 is replaced by a phenyl group.


A dichlorobiphenyl that is 1,3-dichlorobenzene in which the hydrogen at position 5 has been replaced by a phenyl group.


ixazomib

A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixazomib citrate, it is used in combination therapy for treatment of multiple myeloma.


An member of the class of biphenyls that is 2,2',5,5'-tetrachlorobiphenyl in which the 4 and 4' positions are substituted by methylsulfonyl groups.


name: 4-(2,4-dichlorophenoxy)butanoic acid [2-oxo-2-[(phenylmethyl)amino]ethyl] ester


(S)-sulconazole

A 1-{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole that has S configuration.


IXAZOMIB CITRATE

A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of 2,2'-{2-[(1R)-1-amino-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diyl}diacetic acid. A prodrug for ixazomib that is used in combination therapy for treatment of multiple myeloma.


A member of the class of hydroxybiphenyls that is biphenyl-4-ol with chlorine atoms substituted at positions 2 and 6.


vilanterol

An dichlorobenzene derivative that is used in the form of its trifenate salt for treatment of chronic obstructive pulmonary disease.


TOLCOFOS-METHYL

An organic thiophosphate that is 2,6-dichloro-4-methylphenol in which the hydrogen of the hydroxy group group has been replaced by a dimethoxyphosphorothioyl group. Tolclofos-methyl is a phospholipid biosynthesis inhibitor and fungicide that is used for controlling soil-borne diseases caused by Typhula incarnata, Corticium rolfsii, Typhula ishikariensis, and Rhizoctonia solani.


A dichlorobenzene carrying chloro substituents at positions 1 and 2.


triclosan

An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.


linkable PD173955 analogue

An analogue of PD173955 where the methylmercapto group is replaced by aminomethyl.


FENPICLONIL

A member of the class of pyrroles carrying cyano and 2,3-dichlorophenyl substituents at positions 3 and 4 respectively. A fungicide used mainly to control seed-borne pathogens in cereal crops.


N-(3,4-dichlorophenyl)malonamic acid

A dicarboxylic acid monoamide that is the mono-(3,4-dichloroanilide) of malonic acid.


FENOXASULFONE

A dichlorobenzene that is benzene in which the hydrogens at positions 1, 2, 4 and 5 are replaced by [(5,5-dimethyl-4,5-dihydro-1,2-oxazol-3-yl)sulfonyl]methyl, chloro, ethoxy and chloro groups, respectively. It is a rice herbicide developed by Kumiai Chemical Industry Co. Ltd which displays excellent herbicidal activity against Echinochloa spp. and other annual weeds.


(R)-diclofop-methyl

A methyl 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate that is the (R)-enantiomer of diclofop-methyl.


A member of the class of piperidines that is 2-methylpiperidine in which the hydrogen attached to the nitrogen is replaced by a 3-[(3,4-dichlorobenzoyl)oxy]propyl group.


HEXAFLUMURON

An N-acylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-difluorobenzoyl group, while a hycrogen attached to the other nitorgen is replaced by a 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl group.


fenticonazole

A racemate comprising equimolar amounts of (R)- and (S)-fenticonazole. Used (as its nitrate salt) for the treatment of vaginal candidiasis.


(S)-tioconazole

A 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of tioconazole.


tafamidis

A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis.


A methyl ketone resulting from the formal hydration of the ethynyl group of the herbicide propyzamide. It is a major soil metabolite of propyzamide.


enilconazole

A racemate comprising equimolar amounts of (R)- and (S)-enilconazole. A fungicide used to control a wide range of fungi including Tilletia and Helminthosporium spp. on fruit, vegetables and ornamentals. In veterinary medicine, it is used topically for the treatment of fungal skin infections in cattle, dogs, and horses; it is also used by inhalation for the treatment of aspergillosis in ostriches.


ETACONAZOLE

A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2,4-dichlorophenyl and 1,2,4-triazol-1-ylmethyl groups and at position 4 by an ethyl group. An obsolete fungicide that was used to control powdery mildew on fruit and other crops.


diclomezine

A pyridazinone that is pyridazin-3(2H)-one which is substituted at position 6 by a 3,5-dichloro-4-methylphenyl group. A fugicide, it is used to treat rice sheath blight caused by Rhizoctonia solani.


isoconazole

A racemate comprising equimolar amounts of (R)- and (S)-isoconazole. A broad-spectrum antibacterial drug used (as its nitrate salt) for treatment of dermatomycoses.


A member of the class of pyrazoles that is 1-(2,6-dichlorophenyl)-1H-pyrazole which is substituted by a difluoromethyl group at position 3 and by a 2-(isobutyrylamino)-1,3-thiazol-5-yl group at position 5. It is a a potent cell-permeable inhibitor of LIM kinase 1 and 2.


A dichlorobenzene carrying chloro groups at positions 1 and 4.


pyrifenox

An oxime O-ether that is the O-methyloxime of 2',4'-dichloro-2-(3-pyridyl)acetophenone.  A fungicide used for control of powdery mildew, scab and other fungal pathogens on a range of crops.


JTE-607 free base

A secondary carboxamide resulting from the formal condensation of the carboxy group of 3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoic acid with the amino group of ethyl L-phenylalaninate. It inhibits cytokine production in human peripheral blood mononuclear cells (PBMC's) without causing immunosuppression.


A tertiary carboxamide that is piperazine in which one of the amino groups has undergone condensation with the carboxy group of N-[(2,4-dichlorophenyl)sulfonyl]-L-serine, while the other has undergone condensation with the carboxy group of N-(1-benzothiophen-2-ylcarbonyl)-L-leucine. It is a cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel.


A leucine derivative obtained by fpormal condensation of the secondary amino group of 5-({2,3-dichloro-4-[1-methyl-5-(piperidin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)-2-furoic acid and the carboxy group of N-amidino-L-leucylglycine


A dichlorocatechol carrying chloro groups at positions 3 and 5.


(R)-econazole

A 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (R)-enantiomer of econazole.


A tetrachlorobiphenyl that is biphenyl in which both phenyl groups are substituted by chlorines at positions 3 and 5.


A non-proteinogenic amino acid derivative that is the methyl ester of N-(2,6-dichlorobenzoyl)-3-(2-phenoxy-6-quinolyl)alanine.


fluopicolide

A member of the class of benzamides obtained by formal condensation of the carboxy group of 2,6-dichlorobenzoic acid with the amino group of [3-chloro-5-(trifluoromethyl)pyridin-2-yl]methylamine. A fungicide used for the control of a range of diseases including downy mildew and blight.


(R)-diclofop

A 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoic acid that is the (R)-enantiomer of diclofop.


A member of the class of pyrazoles that is 4,5-dihydro-1H-pyrazole substituted by a 2,4-dichlorophenyl group, carboxy group, carboxy group and methyl group at positions 1,3,5 and 5, respectively.


(R)-chlozolinate

An ethyl 3-(3,5-dichlorophenyl)-5-methyl-2,4-dioxo-1,3-oxazolidine-5-carboxylate that is the (R)-enantiomer of chlozolinate.


2,4-dichlorobenzoic acid

A chlorobenzoic acid that is benzoic acid in which the ring hydrogens at positions 2 and 4 are substituted by chloro groups.


bosutinib

An aminoquinoline that is 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline bearing additional cyano and methoxy substituents at positions 3 and 6 respectively.


ethacrynic acid

An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.


(R,R)-fenoxanil

The stereoisomer of N-(2-cyano-3-methylbutan-2-yl)-2-(2,4-dichlorophenoxy)propanamide obtained by formal condensation of the carboxy group of (R)-2-(2,4-dichlorophenoxy)propanoic acid with the amino group of (R)-2-amino-2,3-dimethylbutanenitrile.


A chloroamino acid that is L-tyrosine carrying chloro- substituents at positions C-3 and C-5 of the benzyl group.


dichlorohydroquinone

A member of the class of  chlorohydroquinones carrying two chloro substituents at unspecified positions.


DICLOFOP

An aromatic ether that is 2-(4-hydroxyphenoxy)propanoic acid in which the hydrogen of the hydroxy group at position 4 has been substituted by a 2,4-dichlorophenyl group.


A dichlorophenol that is phenol carrying chloro substituents at positions 2 and 4.


name: 2-[[5-(2,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]thio]acetic acid ethyl ester


lorglumide

A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-(3,4-dichlorobenzoyl)glutamic acid with the amino group of dipentylamine.


(S,S)-cyclobutrifluram

A N-[2-(2,4-dichlorophenyl)cyclobutyl]-2-(trifluoromethyl)pyridine-3-carboxamide that has 1S,2S-configuration.


2,5-dichlorobenzoic acid

A chlorobenzoic acid that is benzoic acid in which the ring hydrogens at positions 2 and 5 are substituted by chloro groups.


A tetrachlorobiphenyl that is biphenyl in which each of the phenyl groups is substituted at positions 2 and 4 by chlorines.


dichlorophenol

Any chlorophenol carrying chloro substituents.


diclofenamide

A sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma.


tienilic acid

An aromatic ketone that is 2,3-dichlorophenoxyacetic acid in which the hydrogen at position 4 on the benzene ring is replaced by a thiophenecarbonyl group. A loop diuretic used to treat hypertension, it was withdrawn from the market in 1982 due to links with hepatitis.


DICHLOBENIL

A nitrile that is benzonitrile which is substituted by chlorines at positions 2 and 6. A cellulose synthesis inhibitor, it is used as a pre-emergent and early post-emergent herbicide.


DCMU

A member of the class of 3-(3,4-substituted-phenyl)-1,1-dimethylureas that is urea in which both of the hydrogens attached to one nitrogen are substituted by methyl groups, and one of the hydrogens attached to the other nitrogen is substituted by a 3,4-dichlorophenyl group.


A member of the class of  benzamides obtained by the formal condensation of 1H-benzimidazole and  2,4-dichlorobenzoic acid.


(S,R)-fenoxanil

The stereoisomer of N-(2-cyano-3-methylbutan-2-yl)-2-(2,4-dichlorophenoxy)propanamide obtained by formal condensation of the carboxy group of (S)-2-(2,4-dichlorophenoxy)propanoic acid with the amino group of (R)-2-amino-2,3-dimethylbutanenitrile.


(R)-vinclozolin

A 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione that is the (R)-enantiomer of vinclozolin.


An N-acyl amino acid that is N-(2,6-dichlorobenzoyl)alanine in which one of the hydrogens at the beta position has been replaced by a  N 6-(2,6-dimethoxyphenyl)-2-naphthyl group.


3,5-dichlorobenzoic acid

A chlorobenzoic acid that is benzoic acid in which the ring hydrogens at positions 3 and 5 are substituted by chloro groups.


clonidine

A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.


(S,S)-fenoxanil

The stereoisomer of N-(2-cyano-3-methylbutan-2-yl)-2-(2,4-dichlorophenoxy)propanamide obtained by formal condensation of the carboxy group of (S)-2-(2,4-dichlorophenoxy)propanoic acid with the amino group of (S)-2-amino-2,3-dimethylbutanenitrile.


lonidamine

A member of the class of indazoles that is 1H-indazole that is substituted at positions 1 and 3 by 2,4-dichlorobenzyl and carboxy groups, respectively.


(S)-isoconazole

A 1-{2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of isoconazole.


A non-proteinogenic amino acid derivative that is the methyl ester of N-(2,6-dichlorobenzyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]-N-methylalanine.


(R)-fenticonazole

A 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole that is the (R)-enantiomer of fenticonazole.


2,6-dichlorobenzoic acid

A chlorobenzoic acid carrying two chloro groups at positions 2 and 6 respectively.


2,3-dichlorobenzoic acid

A chlorobenzoic acid that is benzoic acid in which the ring hydrogens at positions 2 and 3 are substituted by chloro groups.


(S)-triarimol

A (2,4-dichlorophenyl)(phenyl)pyrimidin-5-ylmethanol that has S configuration.


(S)-miconazole

A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has S) configuration.


neflamapimod

A member of the class of pyrimidopyridazines that is 6H-pyrimido[1,6-b]pyridazin-6-one substituted at positions 2 and 5 by (2,4-difluorophenyl)sulfanyl and 2,6-dichlorophenyl groups respectively


sertaconazole

A racemate comprising equimolar amounts of (R)- and (S)-sertaconazole. A broad spectrum antifungal with added antipruritic and anti-inflammatory activity used (as its nitrate salt) for treatment of various skin infections.


dicloromezotiaz

A pyridopyrimidine that is 9-methyl-2,4-dioxo-2H-pyrido[1,2-a]pyrimidine substituted at positions 1 and 3 by (2-chloro-1,3-thiazol-5-yl)methyl and 3,5-dichlorophenyl groups respectively. A mesoionic insecticide used for control of rice hoppers.


tioconazole

A member of the class of imidazoles that comprises 2-(2,4-dichlorophenyl)ethylimidazole carrying an additional (2-chloro-3-thienyl)methoxy substituent at position 2.


A dichlorobenzene carrying chloro substituents at positions 1 and 3.


bixafen

An aromatic amide obtained by formal condensation of the carboxy group of 3-(difluoromethyl)-1-methylpyrazole-4-carboxylic acid with the amino group of 3',4'-dichloro-5-fluorobiphenyl-2-amine. A fungicide for use in cereals for key stem and leaf disease control including strobilurin-resistant septoria.


diuron-desdimethyl

A member of the class of ureas that is urea substituted by a 3,4-dichlorophenyl group at position 1. It is a metabolite of the herbicide diuron.


name: N-[2-cyano-3-(2,4-dichloroanilino)-1-oxoprop-2-enyl]carbamic acid ethyl ester


name: 2-[[5-(2,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]thio]acetic acid butyl ester


fipronil-desulfinyl

A member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, trifluoromethyl, and amino groups, respectively.


(R)-flufiprole

A 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-[(2-methylprop-2-en-1-yl)amino]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile that has R configuration at the sulfoxide.


fipronil-sulfone

A member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, (trifluoromethyl)sulfonyl, and amino groups, respectively. It is a metabolite of the agrochemical fipronil.


A member of the class of phenylacetic acids that is phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position and a 2-(2-oxoethoxy)ethoxy group at the 5-position.


imibenconazole

A member of the class of imidothioates that is the S-4-chlorobenzyl thioester of N-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanimidothioic acid. Used to control a range of fungal diseases affecting fruit, vegetables, turf and ornamentals. It has a low mammalian toxicity and shows a moderate level of toxicity to fish, daphnia and earthworms but is relatively non-toxic to honey bees, birds and algae.


N-acetyldichloro-L-tyrosine

An L-tyrosine derivative in which an L-tyrosine core has two chloro substituents at each position ortho to the benzyl hydroxy group and an acetyl substituent on the nitrogen atom.


diclofenac

A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.


A member of the class of pryrazoles that is 4-amino-1H-pyrazole-3-carboxylic acid in which the primary amino group has been acylated by a 2,6-dichlorobenzoyl group and in which the carboxylic acid has been converted into a carboxamide by formal condensation with the primary amino group of 4-aminopiperidine.


sertraline

A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.


A member of the class of indolones that is 1,3-dihydro-2H-indol-2-one which is substituted by a (2,6-dichlorobenzyl)sulfonyl group at position 5 and by a (1H-pyrrol-2-yl)methylidene group at position 2, the pyrrole ring of which is substituted by methyl groups at positions 3 and 5, and by a [2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl group at position 4 (the Z,R isomer).


DICHLOROPHENOL INDOPHENOL

1,4-benzoquinone imine having a 3,5-dichloro-4-hydroxyphenyl substituent attached to the nitrogen atom.


acetoprole

A phenylpyrazole insecticide that is 3-acetyl-1H-pyralole which is substituted at positions 1, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, methylsulfinyl, and amino groups, respectively. A GABA-gated chloride channel antagonist, it was formerly used as an insecticide and acaricide for the control of sucking and chewing insect pests.


diniconazole-M

A (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol that is the active R-enantiomer of diniconazole. A fungicide used to control a range of diseases including mildew, bunts and smuts.


A dichlorophenol in which the two chloro substituents are located at positions 3 and 5.


clorgiline

An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.


butoconazole

A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to the nitrogen is substituted by a 4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl group. An antifungal agent, it is used as its nitrate salt in gynaecology for treatment of vulvovaginal infections caused by Candida species, particularly Candida albicans.


ZOXAMIDE

A racemate comprising equimolar amounts of (R)- and (S)-zoxamide.  A fungicide used for the control of various fungal infections including blight in potatoes and tomatoes.


BUTENE-FIPRONIL

A member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, (trifluoromethyl)sulfinyl, and (2-methylprop-2-en-1-yl)nitrilo groups, respectively.


fenoxanil

A four component diastereoisomeric mixture composed of the diastereomeric pair (R,R)- and (R,S)-fenoxanil in an 85:15 ratio with the diastereomeric pair (S,R)- and (S,S)-fenoxanil. A fungicide used mainly for control of rice blast.


A monocarboxylic acid that is the 4',5-dihydroxylated metabolite of diclofenac.


SULCONAZOLE

A member of the class of imidazoles that is 1-ethyl-1H-imidazole in which one of the hydrogens of the methyl group is replaced by a (4-chlorobenzyl)sulfanediyl group while a second is replaced by a 2,4-dichlorophenyl group.


diuron-desmethyl

A member of the class of phenylureas that is urea in which a hydrogens attached to one nitrogen is substituted by a methyl group, and one of the hydrogens attached to the other nitrogen is substituted by a 3,4-dichlorophenyl group. It is a metabolite of diuron.


A member of the class of aminopyrimidines that is pyrimidine substituted by {2-[(6-amino-5-nitropyridin-2-yl)amino]ethyl}amino, 2,4-dichlorophenyl, and 1H-imidazol-1-yl groups at positions 2, 4 and 5, respectively. It is a potent ATP-competitive inhibitor of GSK3alpha and GSK3beta (IC50 values of 0.65 and 0.58 nM, respectively).


fenaminstrobin

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-{2-[({(E)-[(3E)-4-(2,6-dichlorophenyl)but-3-en-2-ylidene]amino}oxy)methyl]phenyl}(methoxyimino)acetic acid with the amino group of methylamine. A broad-spectrum fungicide.


(S,S)-tubulozole

An ethyl [4-({[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}sulfanyl)phenyl]carbamate in which both stereocentres have S-configuration.


(R,R)-cyclobutrifluram

A N-[2-(2,4-dichlorophenyl)cyclobutyl]-2-(trifluoromethyl)pyridine-3-carboxamide that has 1R,2R-configuration.


tecloftalam

A dicarboxylic acid monoamide that is the mono-(2,3-dichloroanilide) of tetrachlorophthalic acid. It is used for the treatment of bacterial leaf blight in paddy rice.


A dichlorobiphenyl that is p-dichlorobenzene in which one of the hydrogens has been replaced by a phenyl group.


(S)-enilconazole

A 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that is the (S)-enantiomer of enilconazole


A monocarboxylic acid that is the 5-hydroxylated metabolite of diclofenac.


(S)-diclofop

A 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoic acid that is the (S)-enantiomer of diclofop.


(R)-penconazole

A 1-[2-(2,4-dichlorophenyl)pentyl]1,2,4-triazole that is the (R)-enantiomer of penconazole.


BROMUCONAZOLE

A member of the class of oxolanes carrying 1,2,4-triazol-ylmethyl and 2,4-dichlorophenyl substituents at position 2 as well as a bromo substituent at position 4.  A foliar applied conazole fungicide for a range of crops including cereals, fruit, vegetables and vines.


(R)-enilconazole

A 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that is the (R)-enantiomer of enilconazole.


A non-proteinogenic amino acid derivative that is the methyl ester of N-(2,6-dichlorobenzoyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alanine.


LEPTOPHOS

An organic phosphonate that is phenylphosphonothioic O,O-acid in which the hydroxy groups are substituted by methoxy and 4-bromo-2,5-dichlorophenoxy groups.


ARASERTACONAZOLE

A 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the active R-enantiomer of sertaconazole and is used (as its nitrate salt) for treatment of vulvovaginal candidiasis. The racemate itself is also used as a broad-spectrum antifungal drug.


PROPANIL

An anilide resulting from the formal condensation of the carboxy group of propanoic acid with the amino group of 3,4-dichloroaniline. It is a herbicide used for the treatment of numerous grasses and broad-leaved weeds in rice, potatoes, and wheat.


(R)-butaconazole

The (R)-enantiomer of butaconazole.


miconazole

A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.


(R)-MICONAZOLE

A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has R configuration.


A salicylanilide derivative with chloride substituents at C-3 and C-5 of the salicylate moiety and at C-3 and C-4 of the anilide moiety.


An alanine derivative that is alanine substituted by a 2,6-dichlorobenzoyl group at the N and a 2-(2,6-dichlorophenyl)-6-quinolyl group at position 3.


A member of the class of piperidinylimidazoles that is 1-methyl-4-(1-propylimidazol-2-yl)piperidine carrying additional 3,4-dichlorophenyl and 2-(cyclopropylamino)pyrimidin-4-yl substituents at positions 4 and 5 respectively.


(R)-tioconazole

A 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (R)-enantiomer of tioconazole.


A dipeptide comprising of phenylglycine derived residues linked by peptide bonds.


(R)-sulconazole

A 1-{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole that has R configuration.


name: N-[2-[5-[(2,4-dichlorophenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]ethyl]carbamic acid tert-butyl ester


A dichlorohydroquinone that is hydroquinone substituted by chloro groups at positions 2 and 6.


rimonabant

A carbohydrazide obtained by formal condensation of the carboxy group of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. It is a potent and selective cannabinoid receptor 1 (CB1R) antagonist. Besides its antagonistic properties, numerous studies have shown that, at micromolar concentrations rimonabant behaves as an inverse agonist at CB1 receptors. The drug was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was later withdrawn from market due to CNS-related adverse effects including depression and suicidal ideation.


LINURON

A member of the class of phenylureas that is N-methyl urea substituted by a methoxy group at position 1 and a 3,4-dichlorophenyl group at position 3.


An N-acyl amino acid that is alanine substituted by a 2,6-dichlorobenzoyl group at the N and a 2-phenoxy-6-quinolyl group at position 3.


(R,R)-tubulozole

An ethyl [4-({[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}sulfanyl)phenyl]carbamate in which both stereocentres have R-configuration.


methyl 2,5-dichlorobenzoate

A methyl ester resulting from the formal condensation of the carboxy group of 2,5-dichlorobenzoic acid with methanol. It as used as a plant growth regulator and fungicide for grafting of grapevines.


(S)-sertaconazole

A 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of sertaconazole.


(R)-triarimol

A (2,4-dichlorophenyl)(phenyl)pyrimidin-5-ylmethanol that has R configuration.


A dichlorophenol with the chloro substituents at positions 2 and 5.


dichlorophenyl dicarboximide fungicide

A dicarboximide fungicide in which the nitrogen of the dicarboximide group is substituted by a dichlorophenyl group.


The (4S,5R)-stereoisomer of isocycloseram.


fipronil-sulfide

A member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, (trifluoromethyl)sulfanyl, and amino groups, respectively. It is a metabolite of the agrochemical fipronil.


TUBULOZOLE

A carbamate ester that is the ethyl ester of [4-({[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}sulfanyl)phenyl]carbamic acid.


destosyl pyrazolate

A member of the class of pyrazoles that is pyrazolynate in which the tosylate ester has been hydrolysed to the corresponding hydroxy compound. The active herbicide of the proherbicides pyrazolynate and pyrazoxyfen.


bithionol

An aryl sulfide that is diphenyl sulfide in which each phenyl group is substituted at position 2 by hydroxy and at positions 3 and 5 by chlorine. A fungicide and anthelmintic, it was used in various topical drug products for the treatment of liver flukes, but withdrawn after being shown to be a potent photosensitizer with the potential to cause serious skin disorders.


felodipine

The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.


5-hydroxydiclofenac quinone imine

A quinone imine that is a metabolite of diclofenac arising from 5-hydroxylation followed by oxidation.


avilamycin A

An oligosaccharide derivative that is produced by Streptomyces viridochromogenes and exhibits antibiotic properties.


cyclanilide

A monocarboxylic acid that is cyclopropanecarboxylic acid that is substituted by a 3,5-dichlorophenylcarbamoyl group at position 1. It is a plant growth regulator which is used as a cotton harvest aid.


A non-proteinogenic amino acid derivative that is methyl alaninate substituted by a tert-butoxycarbonyl group at the N and a 2-(2,6-dichlorophenyl)-4-(phenylsulfanyl)-1,2,3,4,4a,8a-hexahydro-6-quinolyl group at position 3.


(R)-DICHLORPROP

The R- (active) enantiomer of dichlorprop. It is used as a herbicide for killing annual and broad leaf weeds.


TRIARIMOL

A member of the class of pyrimidines that is methanol in which the hydrogens of the methyl group have been replaced by pyrimidin-5-yl, phenyl, and 2,4-dichlorophenyl groups, respectively.


diniconazole

A racemate comprising equimolar amounts of (R)- and (S)-diniconazole. A fungicide used to control a range of diseases including mildew, bunts and smuts.


(R)-leptophos

The (R)-enantiomer of leptophos.


(S)-crizotinib

A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that is the (S)-enantiomer of crizotinib.


An N(2)-acyl-L-glutamine that is L-glutamine in which one of the hydrogens of the alpha-amino group has been replaced by a 4-(2,4-dichlorophenoxy)butanoyl group.


A benzoxazine that is 2H-1,4-benzoxazin-3(4H)-one substituted by a hydroxy group at position 5 and a 2-{[2-(cyclohexyl{N-[2-(3,4-dichlorophenyl)ethyl]-beta-alanyl}amino)ethyl]amino}ethyl group at position 8. It is a potent and selective inhibitor of SMYD2.


(S)-lorglumide

An N(2)-(3,4-dichlorobenzoyl)-N,N-dipentyl-alpha-glutamine that has (S)-configuration (the racemate is lorglumide, a CCK antagonist).


FIPRONIL

A racemate comprising equimolar amounts of (R)- and (S)-fipronil.


(S)-diclofop-methyl

A methyl 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate that is the (S)-enantiomer of diclofop-methyl.


The (4R,5R)-stereoisomer of isocycloseram.


A dichlorohydroquinone that is hydroquinone substituted by chloro groups at positions 2 and 5 respectively.


An  alanine derivative that is alanine substituted by  a methyl and a 2,6-dichlorobenzyl group at N and a 2-(2,6-dichlorophenyl)-6-quinolyl group at position 3.


(S)-diniconazole

A (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol that is the (S)-enantiomer of diniconazole.


An alpha-amino acid ester that is methyl alaninate substituted by a 2-(2,6-dichlorophenyl)quinolin-6-yl group at position 3.


(R)-mefenpyr

A 1-(2,4-dichlorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-3,5-dicarboxylic acid that has R configuration.


A  dichlorobenzoyl-CoA having 2,4-dichlorobenzoyl as the S-acyl group.


A pyrazolylpiperidine that consists of 4-(pyrazol-1-yl)piperidine carrying a 2-amino-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-5-yl group at the 4-position of the pyrazole ring.


A member of the class of cyclobutanes that is cyclobutane substituted by [2-(trifluoromethyl)pyridine-3-carbonyl]amino and 2,4-dichlorophenyl groups at positions 1 and 2, respectively.


A hydroxybiphenyl that is catechol in which the hydrogen at position 3 has been replaced by a 2,6-dichlorophenyl group.


tiorantraniliprole

A secondary carboxamide resulting from the formal condensation of the carboxylic acid group of 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid with the primary amino group of 2-amino-3,5-dichloro-N-(propan-2-yl)benzenecarbothioamide. It is an insecticide from Zhejiang Udragon Bioscience.


azafenidin

A triazolopyridine that is 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one which is substituted at position 2 by a 2,4-dichloro-5-(prop-2-yn-1-yloxy)phenyl group. A protoporphyrinogen oxidase inhibitor, it is used as a herbicide to control weeds in fruit crops such as pineapple, citrus, melons, and grapes. Not approved for use within the European Union.


econazole

A racemate composed of equimolar amounts of (R)- and (S)-econazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections.


A member of the class of  hydroxybiphenyls formed formally by chlorination of biphenyl-4,4'-diol at C-3, -3', -5 and -5'.


An member of the class of hydroxybiphenyls formed formally by chlorination of biphenyl-3-ol at C-2' and -5'.


A dichlorophenol with the chloro substituents at positions 2 and 6.


A member of the class of  hydroxybiphenyls that is biphenyl-4-ol substituted by chloro groups at positions 2', 3, 5 and 5' respectively.


A dichlorocatechol in which the two chloro groups are located at positions 3 and 6.


CHLORONEB

A dimethoxybenzene that is p-dimethoxybenzene which is substituted by chlorines at positions 2 and 5. A fungicide formerly used as a seed treatment, it is not approved for use in the European Union.


A monocarboxylic acid that is the 4'-hydroxylated metabolite of diclofenac.


oxiconazole

An oxime O-ether that is the 2,4-dichlorobenzyl ether of the oxime obtained by formal condensation of hydroxylamine with the carbonyl group of acetopnenone in which the phenyl group is substituted by chlorines at positions 2 and 4, and in which one of the hydrogens of the methyl group is replaced by a 1H-imidazol-1-yl group. An antifungal agent, it is used (generally as the nitrate salt) in creams and powders for the topical treatment of fungal skin infections.


A naphthalen-1-one having an N-2,4-dichlorophenylglycinamido group at the 2-position and a [(2,4-dichlorophenyl)amino]sulfonyl group at the 7-position.


pyrafluprole

A member of the class of pyrazoles that is 1H-pyrazole which is substituted by a 2,6-dichloro-4-(trifluoromethyl)phenyl, nitrile, (fluoromethyl)sulfanediyl and [(pyrazin-2-yl)methyl]nitrilo groups at positions 1,3,4 and 5, respectively. It is an experimental insecticide introduced by Nihon Nohyaku Co Ltd, Japan.


A tetrachlorobiphenyl that is biphenyl in which the hydrogens at the 2 and 5 position of each benzene ring are replaced by chlorines.


name: Stage IV Adrenal Cortex Carcinoma AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


description: A sympathetic paraganglioma arising from the retroperitoneum, outside the adrenal gland.


Childhood Adrenal Cortical Carcinoma

description: A carcinoma that arises from the adrenal cortex and occurs during childhood.


Retroperitoneal Ganglioneuroma

description: A ganglioneuroma arising from the retroperitoneum.


name: Adrenal Cortical Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of adrenal cortical carcinoma, following the rules of the TNM AJCC v7 classification system.


Adrenal Cortical Oncocytic Carcinoma

description: A carcinoma that arises from the adrenal cortex and is composed of oncocytic cells that constitute more than 90% of malignant cells.


name: Stage III Adrenal Cortex Carcinoma AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, Any N, M0); (T4, Any N, M0). T1: Tumor measuring 5 cm or less in greatest dimension, with no extra-adrenal invasion. T2: Tumor measuring more than 5 cm in greatest dimension, with no extra-adrenal invasion. T3: Tumor of any size with local invasion but not invading adjacent organs. T4: Tumor of any size that invades adjacent organs (kidney, diaphragm, pancreas, spleen, or liver) or large blood vessels (renal vein or vena cava). N1: Metastasis in regional lymph node(s). M0: No distant metastasis. (from AJCC 8th Ed.)


name: Adrenal Cortical Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of adrenal cortical carcinoma, following the rules of the TNM AJCC v8 classification system. Adrenal medullary pheochromocytoma is staged according to the classification for adrenal neuroendocrine tumors. There is no AJCC staging system for neuroblastic tumors of the adrenal gland. (from AJCC 8th Ed.)


Adrenal Cortical Oncocytic Adenoma

description: A usually non-functioning variant of adrenal cortex adenoma, composed of large cells with abundant granular eosinophilic cytoplasm.


name: Glomerulosa Cell Adrenal Cortical Adenoma

description: An adenoma of the adrenal cortex composed of neoplastic cells with cytologic features of glomerulosa cells.


name: Stage III Adrenal Cortex Carcinoma AJCC v7

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0).  T1: Tumor 5 cm or less in greatest dimension, no extra-adrenal invasion.  T2: Tumor greater than 5 cm, no extra-adrenal invasion.  T3: Tumor of any size with local invasion, but not invading adjacent organs.  N1: Metastasis in regional lymph node(s).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Adrenal Gland Ganglioneuroma

description: A ganglioneuroma arising from the adrenal gland.


Adrenal Gland Lipoma

description: A rare lipoma that arises from the adrenal gland.


name: Recurrent Adrenal Gland Pheochromocytoma

description: The reemergence of pheochromocytoma following surgical removal.


Clear Cell Adrenal Cortical Adenoma

description: An adenoma of the adrenal cortex composed of neoplastic clear cells containing intracytoplasmic lipid droplets.


name: Stage IV Adrenal Cortex Carcinoma AJCC v7

description: Stage IV includes: (T3, N1, M0); (T4, N0, M0); (T4, N1, M0); (Any T, Any N, M1).  T3: Tumor of any size with local invasion, but not invading adjacent organs.  T4: Tumor of any size with invasion of adjacent organs.  N1: Metastasis in regional lymph node(s).  N0: No regional lymph node metastasis.  M0: No distant metastasis. M1: Distant metastasis.  (AJCC 7th ed.)


name: Retroperitoneal Gastrointestinal Stromal Tumor

description: A gastrointestinal stromal tumor that arises from the retroperitoneum. This is an extragastrointestinal tumor, meaning that it does not arise directly from the gastrointestinal tract.


Leiomyoma of the adrenal gland

description: A rare leiomyoma that arises from the adrenal gland.


Benign neoplasm of retroperitoneum

description: A neoplasm that arises from the retroperitoneum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Benign neoplasm of adrenal cortex

description: A neoplasm that arises from the adrenal cortex and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Childhood Adrenal Cortical Adenoma

description: An adenoma of the adrenal cortex that occurs during childhood.


name: Stage I Adrenal Cortex Carcinoma AJCC v7

description: Stage I includes: T1, N0, M0.  T1: Tumor 5 cm or less in greatest dimension, no extra-adrenal invasion. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Hereditary Adrenal Gland Pheochromocytoma

description: A hereditary adrenal gland pheochromocytoma caused by mutations in SDHB, SDHC, and SDHD genes.


Adrenal Cortical Adenomatoid Tumor

description: A benign adrenal cortical neoplasm deriving from mesothelial cells.


name: Locally Advanced Adrenal Gland Pheochromocytoma

description: Adrenal gland pheochromocytoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Adrenal Cortical Myxoid Carcinoma

description: A carcinoma that arises from the adrenal cortex and is characterized by the presence of abundant extracellular connective tissue mucin.


name: Locally Advanced Adrenal Cortical Carcinoma

description: Adrenal cortical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Adrenal Gland Lymphangioma

description: A rare lymphangioma that arises from the adrenal gland.


name: Stage II Adrenal Cortex Carcinoma AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Tumor greater than 5 cm, no extra-adrenal invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Adrenal Gland Lymphoma

description: A rare lymphoma that arises from the adrenal gland.


Adrenal Cortical Low Grade Carcinoma

description: A carcinoma that arises from the adrenal cortex and is characterized by the presence of twenty or less mitoses per ten square millimeters.


name: Metastatic Adrenal Gland Composite Pheochromocytoma

description: An adrenal gland composite pheochromocytoma that metastasizes to other anatomic sites.


Metastatic Adrenal Cortical Carcinoma

description: A carcinoma that arises from the adrenal cortex and has metastasized to another anatomic site.


Adrenal Gland Hemangioma

description: A rare hemangioma that arises from the adrenal gland.


name: Superior and Inferior Paraaortic Paraganglioma

description: An extra-adrenal sympathetic paraganglioma arising from paraganglia located along the aorta, including suprarenal, infrarenal, and renal hilar sites.  In functional tumors, the hypersecretion of catecholamines results in hypertension.


name: Metastatic Carcinoma in the Adrenal Cortex

description: A carcinoma that has spread to the adrenal cortex from an adjacent or distal anatomic site.


name: Androgen-Producing Adrenal Cortical Adenoma

description: A rare adenoma of the adrenal cortex that produces androgens.  Female patients usually have symptoms related to virilism.


name: Unresectable Adrenal Gland Pheochromocytoma

description: Adrenal gland pheochromocytoma that is not amenable to surgical resection.


Compact Cell Adrenal Cortical Adenoma

description: An adenoma of the adrenal cortex composed of neoplastic compact cells with eosinophilic cytoplasm.


Adrenal Cortical Sex Cord-Stromal Tumor

description: An extremely rare sex cord-stromal tumor that arises from the adrenal cortex. The reported cases were solitary and unilateral.


name: Adrenal Gland Composite Pheochromocytoma

description: A neoplasm that arises from the adrenal medulla and combines morphologic characteristics of pheochromocytoma and neuroectodermal tumors such as neuroblastoma, ganglioneuroma, ganglioneuroblastoma, or peripheral nerve sheath tumor.


name: Adrenal Gland Ganglioneuroblastoma, Intermixed

description: An intermixed ganglioneuroblastoma arising from the adrenal gland.


Adrenal Cortical High Grade Carcinoma

description: A carcinoma that arises from the adrenal cortex and is characterized by the presence of more than twenty mitoses per ten square millimeters.


name: Stage I Adrenal Cortex Carcinoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor measuring 5 cm or less in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Advanced Adrenal Gland Pheochromocytoma

description: An adrenal gland pheochromocytoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Adrenal Cortical Melanoma

description: A rare melanoma that arises within the adrenal cortex.


Adrenal Gland Schwannoma

description: A rare schwannoma that arises from the adrenal medulla.


Mixed Cell Adrenal Cortical Adenoma

description: An adenoma of the adrenal cortex composed of a mixed neoplastic cellular population, including varying numbers of neoplastic clear and compact cells.


name: Stage II Adrenal Cortex Carcinoma AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor measuring more than 5 cm in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Adrenal Gland Ganglioneuroblastoma, Nodular

description: A nodular ganglioneuroblastoma arising from the adrenal gland.


Unresectable Adrenal Cortical Carcinoma

description: Adrenal cortical carcinoma that is not amenable to surgical resection.


name: Recurrent Malignant Retroperitoneal Neoplasm

description: The reemergence of a malignant retroperitoneal neoplasm after a period of remission.


name: Non-Metastatic Adrenal Gland Composite Pheochromocytoma

description: A composite pheochromocytoma that is confined to the adrenal gland.


Regional Adrenal Gland Pheochromocytoma

description: A pheochromocytoma that has not spread to other regions.


name: Heavily Pigmented Adrenal Cortical Adenoma

description: A usually functioning adenoma of the adrenal cortex. Grossly, it has a dark brown appearance and is characterized by the presence of neoplastic cells containing abundant intracytoplasmic lipofuscin. It may be associated with Cushing syndrome.


Recurrent Adrenal Cortical Carcinoma

description: The reemergence of adrenal cortical carcinoma after a period of remission.


Anaplastic adrenocortical carcinoma

description: A carcinoma that arises from the adrenal cortex and is characterized by the partial or complete loss of adrenal cortical differentiation.


Refractory Adrenal Cortical Carcinoma

description: Adrenal cortical carcinoma that is resistant to treatment.


name: estrogen-producing adrenal cortical adenoma

description: A rare adenoma of the adrenal cortex that produces estrogens.  Male patients may develop gynecomastia and impotence.


name: Metastatic malignant neoplasm to adrenal gland

description: A malignant tumor that has spread to the adrenal gland from an adjacent or distant anatomic site.  The majority of cases are metastatic carcinomas, and less frequently lymphomas.


trans-4-hydroxy-L-proline residue

An alpha-amino-acid residue derived from trans-4-hydroxy-L-proline.


ceftazidime

A third-generation cephalosporin antibiotic bearing pyridinium-1-ylmethyl and {[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.