Vaginal Blue Nevus

description: A neoplasm that arises from the vagina and is characterized by the proliferation of subepithelial benign dendritic melanocytes.


N-isovalerylsarcosine

An N-acyl-amino acid resulting from the formal condensation of carboxy group of isovaleric acid with the amino group of sarcosine.


notoamide D

An organic heterohexacyclic compound isolated from a mussel-derived Aspergillus species that is 3,6b,7,7a,10,11,12,12a,14a,15-decahydro-8H,13H-pyrano[2,3-g]pyrrolo[1'',2'':4',5']pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-8,13-dione which is substituted by two methyl groups at position 3, a hydroxy group at the 6b position, and a 2-methylbut-3-en-2-yl group at the 14a position (the 6bR, 7aS, 12aS, 14aS stereoisomer).


name: chronic intervillositis of unknown etiology

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


phosphatidylglycerol (18:1/16:1)

A phosphatidylglycerol 34:2 in which the acyl group at C-1 contains 18 carbons and 1 double bond while that at C-2 contains 16 carbons and 1 double bond.


phosphatidylglycerol 34:2

A phosphatidylglycerol in which the two acyl groups contain a total of 34 carbon atoms and 2 double bonds.


A phosphatidylglycerol (18:1/16:1) in which the 1- and 2-acyl groups are specified as oleoyl and (3E)-hexadecenoyl respectively.


phosphatidylglycerol (18:2/16:0)

A phosphatidylglycerol 34:2 in which the 1- and 2-acyl groups are specified as octadecadienoyl and hexadecanoyl respectively.


Charcot-Marie-Tooth disease type 2B

description: Autosomal dominant Charcot-Marie-Tooth disease type 2B (CMT2B) is a severe form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy. CMT2B onset, in the 2nd or 3rd decade, is characterized by ulcerations and infections of feet. Symmetric and distal weakness develops mostly in the legs together with a severe symmetric distal sensory loss, tendon reflexes are only reduced at ankles and foot deformities, including pes cavus or planus and hammer toes, appear in childhood.


PIGA Deficiency

description: An X-linked recessive inherited disorder caused by loss of function mutations in the PIGA gene. It is characterized by deficient GPI-anchor synthesis. Patients may develop somatic paroxysmal nocturnal hemoglobinuria (PNH) or multiple congenital anomalies-hypotonia-seizures syndrome 2 (MCAHS2; early infantile epileptic encephalopathy 20; EIEE20).


A 1,2-diacyl-3-(beta-D-galactosyl)-sn-glycerol in which the 1- and 2- acyl groups are specified as (9S,13S-12-oxophytodienoyl) and (7Z,10Z,13Z)-hexadecatrienoyl respectively.


name: 2-[(2S,5S,6S)-6-(hydroxymethyl)-5-(1-oxopropylamino)-2-oxanyl]acetic acid methyl ester


3-methoxycatechol monosulfate

An aryl sulfate obtained by sulfation of one of the phenolic hydroxy groups of 3-methoxycatechol.


Group A carbohydrate

A polysaccharide composed of a [3)-alpha-Rhap-(1->2)-alpha-Rhap-(1->]n rhamnose polysaccharide backbone with a beta-D-GlcpNAc side-chain modification on every alpha-1,2-linked rhamnose. A bacterial peptidoglycan-anchored surface rhamnose polysaccharide that is essential for growth of Streptococcus pyogenes and contributes to its ability to infect the human host.


name: protein tyrosine kinase collagen receptor activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.


alpha-ascarylopyranose

An ascarylopyranose that has alpha configuration at the anomeric centre.


ascarylose

A dideoxyhexose that is L-arabinohexose in which the hydroxy groups at positions 3 and 6 are replaced by hydrogen.


aldehydo-ascarylose

An aldehyde that is the acyclic form of ascarylose.


ascarylopyranose

A lactol that is the pyranose form of ascarylose.


name: nystagmus 3, congenital, autosomal dominant


cyclodepsipeptide 2

An 18-membered cyclodepsipeptide having a 3-formamido-2-hydroxybenzoyl group attached to the amino terminus. It is isolated from an Alaskan Kitasatospora sp. and exhibits antineoplastic activity.


name: 4-[[2-[(1,1-dioxo-3-thiolanyl)amino]-2-oxoethyl]thio]-2,5-dimethyl-6-thieno[2,3-d]pyrimidinecarboxylic acid ethyl ester


spondylo-ocular syndrome

description: Spondylo-ocular syndrome is a very rare association of spinal and ocular manifestations that is characterized by dense cataracts, and retinal detachment along with generalized osteoporosis and platyspondyly. Mild craniofacial dysphormism has been reported including short neck, large head and prominent eyebrows.


A hydrochloride salt resulting from the formal reaction of 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine with 2 mol eq. of hydrogen chloride. It is a selective inhibitor of the delta- and epsilon-isoforms of casein kinase 1 (CK1delta and CK1epsilon).


name: neurological muscular channelopathy due to a genetic chloride channel defect


A 4-formylzymosterol in which the formyl group at position 4 has alpha-configuration.


A 3beta-sterol that is zymosterol which carries a formyl group at position 4.


Solid Cystic Hidradenoma

description: A hidradenoma characterized by the presence of solid lobular neoplastic cell proliferations and cystic spaces filled with homogeneous eosinophilic material.


BAPTA

A polyamino carboxylic acid in which bis(carboxymethyl)nitrilo groups are bonded to C-2 and C-2' of 1,1'-[ethane-1,2-diylbis(oxy)]dibenzene.


polyamino carboxylic acid

An amino acid containing one or more nitrogen atoms connected through carbon atoms to one or more carboxy groups.


ethylenediaminediacetic acid

An ethylenediamine derivative in which two of the four amine protons of ethylenediamine are replaced by carboxymethyl groups.


A polyamino carboxylic acid, the structure of which is that of BAPTA carrying bromine substituents at C-5 and C-5'.


ethylenediaminetriacetic acid

An ethylenediamine derivative in which three of the four amine protons of ethylenediamine are replaced by carboxymethyl groups.


A polyamino carboxylic acid, the structure of which is that of BAPTA carrying methyl substituents at C-5 and C-5'.


zearalenone hapten ZEp

A macrolide that is an immunizing hapten of the mycotoxin zearalenone which incorporates a carboxylated five-carbon long aliphatic spacer arm through the oxygenated quasi-distal position at C-14.


Acute Thymic Involution

description: The sudden shrinking and/or complete disappearance of the thymus gland; this often happens as a response to a physiologic stressor, such as infection or malnutrition.


factor XIII deficiency, cattle

description: Factor XIII deficiency that occurs in cattle.


2'-phospho-5'-adenylyl sulfate

An adenosine bisphosphate having monophosphate groups at the 2'- and 5'-positions and a sulfo group attached to the phosphate at position 5'.


The indole alkaloid cation that is the conjugate acid of 16-hydroxytabersonine, arising from protonation of the tertiary amino function; major species at pH 7.3.


A tertiary amino compound that is p-methoxybenzylamine in which the hydrogens attached to the amino group have been replaced by a methyl group and a 2,2-bis(hydroxymethyl)propyl group. Obtained from 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine by hydrolysis of the oxetane moiety using human liver microsomes.


juvenile open angle glaucoma

description: Juvenile glaucoma (JG) is a rare autosomal dominant open angle glaucoma, characterized by early onset, severe elevation of intra ocular pressure of rapid progression, leading to optic nerve excavation and, when untreated, substantial visual impairment.


glaucoma 1, open angle, O

description: Any open-angle glaucoma in which the cause of the disease is a mutation in the NTF4 gene.


low tension glaucoma

description: A form of glaucoma in which chronic optic nerve damage and loss of vision normally attributable to buildup of intraocular pressure occurs despite prevailing conditions of normal intraocular pressure.


OPTN-related open angle glaucoma

description: Any open angle glaucoma in which the cause of the disease is a mutation in the OPTN gene.


glaucoma 1, open angle, A

description: Any juvenile glaucoma in which the cause of the disease is a mutation in the MYOC gene.


A 1,2-diacyl-sn-glycero-3-phosphoethanolamine in which both acyl substituents are specified as (9E)-octadecenoyl.


name: posterior fusion of lumbosacral vertebrae-blepharoptosis syndrome

description: Posterior fusion of lumbosacral vertebrae-blepharoptosis syndrome is characterized by congenital ptosis and posterior fusion of the lumbosacral vertebrae. It has been described in a mother and her two daughters.


name: persistent polyclonal B-cell lymphocytosis

description: Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare, generally benign, lymphoproliferative hematological disease characterized by: chronic, stable, persistent, polyclonal lymphocytosis of memory B-cell origin, the presence of binucleated lymphocytes in the peripheral blood, and a polyclonal increase in serum immunoglobulin M (IgM). Patients are most frequently asymptomatic or may present with mild splenomegaly.


An imidazolidine-2,4-dione substituted by a hydroxymethyl group at position 1 and two methyl groups at position 5. It is approved by the FDA for use as an adjuvant in the bleaching of recycled paper and board used in food packaging, and is also a decomposition product of DMDM hydantoin, a preservative and antimicrobial agent used in cosmetics and personal care products.


(S)-ethotoin

The (S)-enantiomer of ethotoin.


imidacloprid

The E-isomer of imidacloprid.


name: 4-[(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)methyl]benzoic acid methyl ester


hydantoin-5-propionic acid

A imidazolidine-2,4-dione that is hydantoin substituted by a 2-carboxyethyl group at position 4.


imidapril

A member of the class of imidazolidines that is (4S)-1-methyl-2-oxoimidazolidine-4-carboxylic acid in which the hydrogen of the imidazolidine nitrogen has been substituted by (1S)-1-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}ethyl group. It is the prodrug for imidaprilat, an ACE inhibitor used for the treatment of chronic heart failure.


azumolene

A 1,3-oxazole which is substituted by a [(2,4-dioxoimidazolidin-1-yl)imino]methyl group at position 2 and a 4-bromophenyl group at position 5. It is a muscle relaxant used for the treatment/prevention of malignant hyperthermia.


sorbinil

An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.


(R)-ethotoin

The (R)-enantiomer of ethotoin.


An imidazolidine-2,4-dione substituted by a 4-hydroxybutyl group at position 5.


dethiobiotin

A hexanoic acid having a 5-methyl-2-oxoimidazolidin-4-yl group at the 6-position.


parabanic acid

An imidazolidinone that is imidazolidine which is substituted by oxo groups at positions 2, 4 and 5.


D-5-monosubstituted hydantoin

Any imidazolidine-2,4-dione that bears a single substituent at position 5 and has D-configuration.


(3R,4S)-BW 245C

A 7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid that is the (3R,4S)-enantiomer of BW 245C.


N-desmethylenzalutamide

A benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with ammonia.


N-methylhydantoin

A imidazolidine-2,4-dione that is the N-methyl-derivative of hydantoin.


A D-5-monosubstituted hydantoin in which the substituent is specified as 2-(methylthio)ethyl.


nifurtoinol

An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group and at position 3 by a hydroxymethyl group.


enzalutamide

A benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with methylamine. Used for the treatment of of metastatic castration-resistant prostate cancer.


An imidazolidinone that is imidazolin-2-one substituted at positions 4 and 5 by hydroxy and ureido groups respectively.


HYDANTOIN

An imidazolidinone with oxo groups at position 2 and 4.


IPRODIONE

An imidazolidine-2,4-dione in which the nitrogen at position 1 is substituted by an N-(isopropyl)carboxamide group while that at position 3 is substituted by a 3,5-dichlorophenyl group. A contact fungicide, it blocks the growth of the fungal mycelium and inhibits the germination of fungal spores. It is used on fruit and vegetable crops affected by various fungal diseases. It is also used as a nematicide.


A member of the class of imidazolidinones that is 1,5,5-trimethyl-2-oxoimidazolidine bearing additional m-chlorophenyl and N'-p-chlorophenylureido substituents at positions 3 and 4 respectively.


BW 245C

A imidazolidine-2,4-dione that is 7-(2,5-dioxoimidazolidin-4-yl)heptanoic acid in which the imidazoline ring as substituted at position 3 by a 3-(3-cyclohexyl-3-hydroxypropyl) group.


sertindole

A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-oxoimidazolidin-1-yl)ethyl group.


A D-5-monosubstituted hydantoin that is  imidazolidine-2,4-dione in which the pro-R hydrogen at position 5 has been replaced by a phenyl group.


mephenytoin

An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.


imiprothrin

Mixture of 20% (1R)-cis- (CHEBI:39372) and 80% (1R)-trans- (CHEBI:39373) isomers.


A carboxamide resulting from the formal condensation of the primary amino group of 4-propanoyl-1,3-thiazol-2-amine with the carboxy group of a 3-phenylbutiyric acid which has been substituted at position 2 by a (4R)-4-[p-(2-hydroxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl group. It is a potent, highly selective inhibitormitogen-activated protein kinase 1/2 inhibitor.


dantrolene

The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.


The (4R,5S)-isomer of dethiobiotin.


name: 2-[4-[4-(difluoromethoxy)phenyl]-4-methyl-2,5-dioxo-1-imidazolidinyl]acetic acid ethyl ester


ethotoin

An imidazolidine-2,4-dione that is hydantoin substituted by ethyl and phenyl at positions 3 and 5, respectively. An antiepileptic, it is less toxic than phenytoin but also less effective.


allantoin

An imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen.


(3S,4R)-BW 245C

A 7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid that is the (3S,4R)-enantiomer of BW 245C.


imidazolidinone

An imidazolidine containing one or more oxo groups.


(S)-(+)-allantoin

An optically active form of allantoin having (S)-(+)-configuration.


name: N-[1,3-dimethyl-2-oxo-5-[[oxo(propoxy)methyl]amino]-4-imidazolidinyl]carbamic acid propyl ester


imidacloprid-urea

A imidazolidinone that is imidazolidin-2-one substituted by a (6-chloropyridin-3-yl)methyl group at position 1. It is a metabolite of the insecticide imidacloprid.


An imidazolidine-2,4-dione having a carboxymethyl group at the 5-position.


furagin

An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [3-(5-nitro-2-furyl)prop-2-en-1-ylidene]amino group (the configuration of the C=C and C=N bonds in the grouping that links the two heterocycles is not specified). A nitrofuran antibiotic with properties similar to nitrofurantoin, furagin is used in the treatment of urinary tract infections.


imidaprilat

A member of the class of imidazolidines that is imidapril in which the ethyl ester group has been hydrolysed to the corresponding acid group. It is the active metabolite of imidapril used to treat hypertension.


bisantrene

A hydrazone resulting from the formal condensation of both of the aldehyde groups of anthracene-9,10-dicarbaldehyde with 2-hydrazinyl-4,5-dihydro-1H-imidazole.


2-Imidazolidone-4-carboxylic acid

This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.


(R)-(-)-allantoin

An optically active form of allantoin having (R)-(-)-configuration.


A member of the class of imidazolidinones that is dethiobiotin carrying a mercapto substituent at position 9. An intermediate in the biosynthesis of biotin.


An imidazolidine-2,4-dione that is  hydantoin substituted by a hydroxy group at position 5.


guanosine 3',5'-bis(diphosphate)

A guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions.


L-methionyl-L-isoleucyl(1+) residue

A cationic dipeptidyl group obtained by protonation of the amino terminus of L-methionyl-L-isoleucyl residue; major species at pH 7.3.


A organic heterooctacyclic compound that is a potent inhibitor of protein kinase C and is isolated from Nocardiopsis sp K-252a


name: phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The phosphatidylcholine biosynthetic process that involves a one-step direct condensation of choline with CDP-diacylglycerol to form phosphatidylcholine.


An aralkylglucosinolate that is the conjugate base of glucotropeolin; major species at pH 7.3.


ALOSETRON HYDROCHLORIDE

The hydrochloride salt of alosetron.


A  tricarboxylic acid amide that is a Good's buffer substance, pKa = 6.6 at 20 degreeC.


Multinodular Adrenal Hyperplasia

description: A subtype of adrenal hyperplasia, based on histopathologic features, in which there are multiple nodules.


cellular response to red light

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.


red light signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.


A N-(long-chain-acyl)ethanolamine that is the ethanolamide of (15Z)-tetracosenoic acid.


An N-acylethanolamine resulting from the formal condensation of the carboxy group of any monounsaturated fatty acid with the amino group of ethanolamine.


N-acylethanolamine 18:1

An N-acylethanolamine in which the acyl group contains 18 carbons and 1 double bond.


N-gondoylethanolamine

A fatty amide obtained by the formal condensation of (11Z)-eicosaenoic acid with ethanolamine.


N-oleoylethanolamide

An N-(long-chain-acyl)ethanolamine that is the ethanolamide of oleic acid. The monounsaturated analogue of the endocannabinoid anandamide.


N-acylethanolamine 16:1

A N-(long-chain-acyl)ethanolamine in which the acyl group contains 16 carbons and 1 double bond.


palmitoleoyl ethanolamide

An N-acylethanolamine 16:1 that is the ethanolamide of palmitoleic acid.


An androstane sulfate that is 5alpha-androstan-3alpha,17beta-diol in which both hydroxy hydrogens have been replaced by sulfo groups.


androstane ester

Any steroid ester based on an androstane skeleton.


An androstane sulfate that is 5alpha-androstan-3beta,17beta-diol in which both hydroxy hydrogens have been replaced by sulfo groups.


An androstane sulfate that is 5alpha-androstan-3alpha,17beta-diol in which the hydroxy hydrogen at position 17 has been replaced by a sulfo group.


An androstane sulfate that is 5alpha-androstan-3alpha,17alpha-diol in which one of the hydroxy hydrogens has been replaced by a sulfo group.


androstane sulfate

Any steroid sulfate based on an androstane skeleton.


An androstane sulfate that is 5alpha-androstan-3beta,17beta-diol in which the hydroxy hydrogen at position 17 has been replaced by a sulfo group.


An androstane sulfate that is 5alpha-androstan-3beta,17alpha-diol in which both hydroxy hydrogens have been replaced by sulfo groups.


U5 snRNA 3'-end processing

description: Any process involved in forming the mature 3' end of a U5 snRNA molecule.


Vulvar Alveolar Rhabdomyosarcoma

description: An extremely rare malignant mesenchymal neoplasm of the vulva exhibiting skeletal muscle differentiation with an alveolar pattern.


BENZOIC ACID 3-HYDROXYPHENYL ESTER

A benzoate ester resulting from the formal condensation of benzoic acid with resorcinol.


ovarian lymphoma

description: A lymphoma that affects the ovary. Lymphomatous involvement of the ovary is rare and in approximately half of the cases both ovaries are affected.


An O-(S-3-oxoacylpantetheine-4'-phosphoryl)-L-serine(1-) residue in which the S-acyl group is specified as 3-oxoicosanoyl.


photosynthesis

description: The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.


name: CYP1B1-related glaucoma with or without anterior segment dysgenesis

description: Any primary congenital glaucoma in which the cause of the disease is a mutation in the CYP1B1 gene.


name: Unresectable Digestive System Mixed Adenoneuroendocrine Carcinoma

description: Digestive system mixed adenoneuroendocrine carcinoma that is not amenable to surgical resection.


methyl beta-D-glucuronoside

A derivative of beta-D-glucuronic acid in which a methyl group is present at the anomeric position.


name: positive regulation of preblastoderm mitotic cell cycle

description: Any process that activates or increases the rate or extent of progression through the preblastoderm mitotic cell cycle.


juvenile polymyositis

description: An idiopathic inflammatory myopathy of childhood resulting in muscle weakness.


A trihydroxy-5beta-cholanic acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3, 7 and 12 (the 3beta,7alpha,12alpha stereoisomer).


name: folate:monoatomic anion antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF.


A non-proteinogenic L-alpha-amino acid that is L-tyrosine substituted by nitro groups at positions 3 and 5.


name: octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol

description: The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter.


name: anaerobic organosilicon metabolic process

description: The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen.


protein localization to nuclear pore

description: A process in which a protein is transported to, or maintained in, a nuclear pore.


name: protein localization to nuclear envelope

description: A process in which a protein is transported to, or maintained at, a location within a nuclear envelope.


name: protein localization to nuclear inner membrane

description: A process in which a protein is transported to, or maintained in, a location within the nuclear inner membrane.


dextrorphan O-glucosiduronic acid

A glucosiduronic acid derived from dextrorphan.


variecolorquinone B

An aromatic ester that is methyl 2-hydroxy-4-methylbenzoate attached to a (6-methoxy-1,4-benzoquinon-2-yl)methyl group at position 6. Isolated from Aspergillus variecolor, it exhibits cytotoxic activity.


A member of the class of tetracenomycins that is 8-demethyltetracenomycin C in which the hydroxyl hydrogen at position 8 is replaced by a 2-O-methyl-alpha-L-rhamnosyl residue.


(S)-rosmarinic acid

The (S)-stereoisomer of rosmarinic acid.


givinostat

A member of the class of naphthalenes that is naphthalene substituted by ({[4-(hydroxycarbamoyl)phenyl]carbamoyl}oxy)methyl and (diethylamino)methyl groups at positions 2 and 6, respectively. It is a histone deacetylase inhibitor indicated for individuals diagnosed with Duchenne muscular dystrophy.


8-methyladenosine 5'-monophosphate

A purine ribonucleoside 5'-monophosphate having 8-methyladenine as the nucleobase.


alpha-D-galactose 6-sulfate

A D-galactose 6-sulfate that has alpha configuration at the anomeric centre.


polysorbate 40

A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by a palmitoyl group.


name: Advanced Pancreatic Neuroendocrine Tumor

description: A pancreatic neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Pancreatic neuroendocrine tumor metastatic

description: A neuroendocrine tumor that arises from the islet cells of the pancreas and has spread to another anatomic site.


name: Advanced Pancreatic Neuroendocrine Tumor G1

description: Pancreatic neuroendocrine tumor G1 that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Metastatic Pancreatic Neuroendocrine Tumor G3

description: Panreatic neuroendocrine tumor G3 that has spread from its original site of growth to another anatomic site.


name: Locally Advanced Pancreatic Neuroendocrine Tumor G3

description: Pancreatic neuroendocrine tumor G3 that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Metastatic Pancreatic Neuroendocrine Tumor G1

description: Pancreatic neuroendocrine tumor G1 that has spread from its original site of growth to another anatomic site.


name: Locally Advanced Pancreatic Neuroendocrine Tumor

description: A pancreatic neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


puerperal disorder

description: Disorders or diseases associated with puerperium, the six-to-eight-week period immediately after parturition in humans.


puerperal infection

description: An infection occurring in puerperium, the period of 6-8 weeks after giving birth.


postpartum psychosis

description: Postpartum psychosis is a rare psychiatric emergency in which symptoms of high mood and racing thoughts (mania), depression, severe confusion, loss of inhibition, paranoia, hallucinations and delusions set in, beginning suddenly in the first two weeks after childbirth. The symptoms vary and can change quickly.


serous cystadenofibroma

description: A benign neoplasm characterized by the presence of cystic structures lined by serous epithelial cells in a fibrotic stroma. Most commonly the primary site is the ovary, but serous cystadenofibromas can occur in the pancreas as well.


uterine corpus apoplectic leiomyoma

description: A morphologic variant of uterine corpus leiomyoma characterized by zones of hemorrhagic infarction surrounded by hypercellular areas. It usually develops in women of childbearing years, particularly those that are pregnant, post-partum, or taking oral contraceptives.


ovarian clear cell adenofibroma

description: An uncommon benign neoplasm of glandular epithelium characterized by the presence of clear or hobnail cells within a dense fibrous stroma.


fibroma of prostate

description: A fibroma that involves the prostate gland.


uterine corpus cellular leiomyoma

description: A morphologic variant of leiomyoma arising from the uterine corpus. It is characterized by a dense cellular infiltrate composed of spindle or round cells with scant cytoplasm and a less obvious interlacing fascicle pattern.


oral fibroma

description: A non-metastasizing oral neoplasm arising from fibrous tissue characterized by the presence of spindle-shaped fibroblasts.


uterine corpus bizarre leiomyoma

description: A morphologic variant of uterine corpus leiomyoma characterized by significant cytologic atypia. The atypical cells are large with pleomophic hyperchromatic nuclei.


uterine corpus dissecting leiomyoma

description: A rare morphologic variant of uterine corpus leiomyoma. Macroscopically, it is characterized by large, fungating, and multinodular neoplasm masses arising from the uterine corpus, and extending into the broad ligament or the peritoneal cavity. Microscopically, it shows neoplastic smooth muscle cells infiltrating the myometrium. The neoplastic cells are arranged in a micronodular pattern. Hydropic changes and increased vascularity are also present.


uterine corpus adenofibroma

description: A usually polypoid, benign neoplasm that arises from the endometrial cavity. It is characterized by the presence of a mesenchymal core component and an epithelial component that forms a lining on the mesenchymal core.


testicular fibroma

description: A benign neoplasm that arises from the testis and is characterized by the presence of fusiform cells and collagenization.


ovarian clear cell cystadenofibroma

description: A benign neoplasm of glandular epithelium characterized by the presence of clear or hobnail cells within a dense fibrous stroma and cystic structures.


cystadenofibroma

description: A benign or borderline neoplasm that arises from the ovaries and the fallopian tubes. It is characterized by the presence of cystic glandular structures and fibrous tissue.


adenofibroma

description: A benign neoplasm characterized by the presence of connective tissue stroma and epithelial structures. It occurs in the ovary, fallopian tube, uterine corpus, and cervix. Cases of adenofibroma of the ovary with low grade malignant potential have also been reported.


clear cell adenofibroma

description: A benign neoplasm characterized by the presence of glandular structures which contain clear cells and a fibrotic stroma.


ovarian endometrioid cystadenofibroma

description: A benign neoplasm of the ovary characterized by the presence of cystic structures lined by endometrial-type well-differentiated cells in a fibrotic stroma.


uterine corpus diffuse leiomyomatosis

description: An unusual condition characterized by the presence of numerous small benign smooth muscle neoplasms located throughout the body of the uterus.


rete ovarii cystadenofibroma

description: An exceptionally rare cystadenofibroma that arises from the rete ovarii.


ovarian serous adenofibroma

description: A benign neoplasm of the ovary characterized by the presence of glands with serous epithelial cells in a fibrotic stroma.


uterine corpus lipoleiomyoma

description: A rare morphologic variant of uterine corpus leiomyoma characterized by the presence of scattered islands of mature adipocytes within the smooth muscle neoplasm.


serous adenofibroma

description: A benign adenofibroma characterized by the presence of serous secretory cells and minute cystic spaces filled with watery fluid. A representative example is the ovarian serous adenofibroma. Cases with epithelial atypia described in the ovary lacking stromal invasion are designated as borderline serous adenofibromas and have a low grade malignant potential.


papillary adenofibroma

description: A biphasic polypoid neoplasm characterized by the presence of papillary projections that are lined by epithelial cells and fibrotic stroma.


tendon sheath fibroma

description: A small, slow growing, benign neoplasm arising from the tendon sheaths. The tumor is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation.


fallopian tube serous adenofibroma

description: A rare, benign, asymptomatic neoplasm that arises from the fallopian tube. The majority of cases are incidental findings during operation for an unrelated gynecologic disorder. The tumors are round and solitary and contain connective tissue and papillary or tubular structures lined by serous-type epithelium.


uterine corpus myxoid leiomyoma

description: A morphologic variant of uterine corpus leiomyoma characterized by extensive myxoid degeneration of the neoplasm connective tissue stroma.


uterine corpus epithelioid leiomyoma

description: A morphologic variant of uterine corpus leiomyoma characterized by the presence of round or polygonal epithelioid smooth muscle cells forming clusters.


clear cell cystadenofibroma

description: A benign neoplasm characterized by the presence of cystic glandular and fibrous tissues and clear cells.


calcified aponeurotic fibroma

description: A rare slow-growing benign neoplasm arising from the soft tissues in children. It is a poorly circumscribed tumor characterized by the presence of chondrocyte-like cells, nodular calcification, nuclear palisading, and in some cases osteoclastic giant cells.


ovarian serous cystadenofibroma

description: A benign neoplasm of the ovary characterized by the presence of cystic structures lined by serous epithelial cells in a fibrotic stroma.


fallopian tube cystadenofibroma

description: A rare, benign, asymptomatic neoplasm that arises from the fallopian tube. The tumors are round and solitary and contain connective tissue and cystic structures lined by serous-type epithelium. The majority of cases are incidental findings during operation for an unrelated gynecologic disorder.


tryptamine

An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position.


A racemate comprising equal amounts of threo-5-hydroxy-D- and -L-lysine.


name: spastic paraplegia, intellectual disability, nystagmus, and obesity


name: deactivation of mitotic spindle assembly checkpoint

description: A positive regulation of the mitotic metaphase/anaphase transition that results from deactivation of the mitotic spindle assembly checkpoint.


name: positive regulation of mitotic sister chromatid segregation

description: Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis.


name: positive regulation of mitotic spindle elongation

description: Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation.


description: Any process that stops, prevents, or reduces the frequency, rate or extent of negative regulation of mitotic spindle assembly checkpoint signaling.


name: positive regulation of mitotic spindle elongation (spindle phase three)

description: Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three).


name: negative regulation of chronic inflammatory response to antigenic stimulus

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.


name: regulation of chronic inflammatory response to antigenic stimulus

description: Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.


name: positive regulation of chronic inflammatory response to antigenic stimulus

description: Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.


A glycolipid, an alpha-L-rhamnosyl-alpha-L-rhamnoside of 3-[(3-hydroxydecanoyl)oxy]decanoic acid.


pent-4-enoic acid

A pentenoic acid having the double bond at position 4.


name: paraparetic variant of Guillain-Barre syndrome

description: Paraparetic variant of Guillain-Barré syndrome is a rare variant of Guillain-Barré syndrome characterized by isolated leg weakness, areflexia and radicular leg pain that may simulate a cauda equina or spinal cord syndrome. The arms, ocular, facial, and oropharyngeal muscles are spared, and sphincteric function is normal.


A glycoside comprising glucose in (1->3) linkage with rhamnose, in turn linked (1->3) to D-ribitol.


syringomyelia, horse

description: Syringomyelia that occurs in horse.


mycinamicin VI(1+)

A mycinamicin cation that is the conjugate acid of mycinamicin VI, obtained by protnation of the tertiary amino group.


name: 3-(2-furanyl)-2-propenoic acid (3-formylphenyl) ester


chronic dacryocystitis

description: Chronic form of dacryocystitis.


An oxonium betaine that is the conjugate base of cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside, arising from deprotonation of the carboxy group; major species at pH 7.3.


name: Recurrent Prostate Acinar Adenocarcinoma

description: The reemergence of prostate acinar adenocarcinoma after a period of remission.


Prostate cancer recurrent

description: Prostate carcinoma reemerging after a period of remission.


name: Adenocarcinoma of the prostate recurrent

description: The reemergence of prostate adenocarcinoma after a period of remission.


name: Recurrent Prostate Small Cell Neuroendocrine Carcinoma

description: The reemergence of prostate small cell neuroendocrine carcinoma after a period of remission.


name: Biochemically Recurrent Prostate Carcinoma

description: Increasing prostate-specific antigen (PSA) following prostatectomy or radiation therapy in a patient with a history of localized prostate carcinoma. Signs of metastasis are absent using the currently available scanning technology.


An alkanesulfonic acid obtained by the formal substitution of one of the methyl hydrogens of propane-1,2-diol by a sulfonic acid group.


An alkanesulfonic acid obtained by the formal substitution of one of the methyl hydrogens of (2S)-propane-1,2-diol by a sulfonic acid group.


ocellus pigment metabolic process

description: The chemical reactions and pathways involving ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates.


ommochrome catabolic process

description: The chemical reactions and pathways resulting in the breakdown of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye.


ocellus pigment catabolic process

description: The chemical reactions and pathways resulting in the breakdown of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates.


ommochrome biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye.


ocellus pigment biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ocellus pigments, general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates.


ommochrome metabolic process

description: The chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye.


benzenetriol

A triol in which three hydroxy groups are substituted onto a benzene ring.


A gallate ester that is the tetraester obtained by the formal condensation of hydroxy groups at positions 1, 2, 3 and 4 of alpha-D-glucose with the carboxy group of four molecules of gallic acid respectively.


A gallate ester obtained by condensation of the carboxy group of gallic acid with the hydroxy group of octanol.


A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.


A benzenetriol that is phloroglucinol in which one of the ring hydrogens has been replaced by an acyl group.


DRUMMONDIN F

A benzenetriol that is a derivative of filicinic acid. Isolated from the stems and leaves of Hypericum drummondii, it exhibits antibacterial activity against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and the acid fast bacterium Mycobacterium smegmatis.


A galloyl-beta-D-glucose compound having the galloyl groups in the 1-, 2- and 6-positions.


HYEMALOSIDE A

A beta-D-glucoside compound having galloyl groups at positions 2, 3 and 6 and a 4-hydroxyphenyl substituent at the 1-position. Isolated from Eugenia hyemalis, it exhibits inhibitory activity against HIV-1.


2,4,5-trihydroxyphenylacetic acid

A benzenetriol that is phenylacetic acid carrying three hydroxy substituents at positions 2, 4 and 5.


ARDIMERIN DIGALLATE

A C-glycosyl compound isolated from the whole plants of Ardisia japonica. It is a dimeric lactone that exhibits inhibitory activity against HIV-1 RNAse H.


OXIDOPAMINE

A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).


PENTAGALLOYL GLUCOSE

A galloyl-beta-D-glucose compound having five galloyl groups in the 1-, 2-, 3-, 4- and 6-positions.


A 2-acyl-4-prenylphloroglucinol in which the acyl group is specified as isobutyryl.


deoxycohumulone

A 2-acyl-4,6-diprenylphloroglucinol in which the acyl group is specified as isobutyryl.


An aromatic ketone that is any 2-acylphloroglucinol in which both of the ring hydrogens have been replaced by prenyl groups.


GALLOCATECHIN GALLATE

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of (-)-gallocatechin. A natural product found in found in green tea.


procyanidin B3 3'-O-gallate

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3'S)-hydroxy group of procyanidin B3.


A 2-acyl-4-prenylphloroglucinol in which the acyl group is specified as 3-methylbutanoyl.


A diester obtained by the formal condensation of gallic acid  with the hydroxy groups at positions 7 and 4' of 3',4',5',5,7-pentahydroxyflavan. Isolated from the leaves of Pithecellobium clypearia, it exhibits antiviral activity.


procyanidin B4 3-O-gallate

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3S)-hydroxy group of procyanidin B4.


(-)-CATECHINGALLATE

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of (-)-catechin.


A a galloyl beta-D-glucose compound having a galloyl group at the 6-position. Isolated from the leaves of Sapium sebiferum, it exhibits antihypertensive activity.


PYROGALLOL

A  benzenetriol carrying hydroxy groups at positions 1, 2 and 3.


ETHYLGALLATE

A gallate ester obtained by the formal condensation of gallic acid with ethanol.


A benzenetriol that is benzophenone in which one of the phenyl groups is substituted by hydroxy groups at positions 2, 3, and 4. It is a redox mediator.


procyanidin B4 3'-O-gallate

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3'R)-hydroxy group of procyanidin B4.


(+)-gallocatechin gallate

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3S)-hydroxy group of (+)-gallocatechin.


EUGENIIN

An ellagitannin isolated from the dried flower buds of Eugenia caryophyllata. It exhibits alpha-glucosidase inhibitory activity and antiviral activity against acyclovir and phosphonoacetic acid (PAA)-resistant herpes simplex virus type 1 (HSV-1) as well as the wild-type HSV-1.


A benzenetriol that is phloroglucinol in which two of the ring hydrogens are replaced by acetyl groups.


A quercetin O-glycoside that consists of quercetin attached to a (2'',3''-digalloyl)-beta-D-galactopyranosyl residue at position 3 via a glycosidic linkage. Isolated from Euphorbia lunulata, it exhibits insulin-like activity.


A benzenetriol carrying hydroxy groups at positions 1, 2 and 4.


locoracemoside C

An O-acyl carbohydrate consisting of 6-O-beta-D-glucopyranosyl-beta-D-glucopyranose attached to a 3,4,5-trimethoxybenzyl and a galloyl group at positions 1 and 3 respectively. Isolated from Symplocos racemosa, it exhibits inhibitory activity against chymotrypsin.


PHLOROISOBUTYROPHENONE

A 2-acylphloroglucinol in which the acyl group is specified as isobutyryl.


theogallin

A gallate ester resulting from the formal condensation of gallic acid with the (5R)-hydroxy group of (-)-quinic acid (i.e. the hydroxy group on the same side of the cyclohexane ring as the carboxy group).


A galloyl-beta-D-glucose compound having a galloyl group at the 1-position.


A gallate ester obtained by the formal condensation of gallic acid with the hydroxy group at position 7 of 3',4',5',5,7-pentahydroxyflavan. Isolated from the leaves of Pithecellobium clypearia, it exhibits antiviral activity.


CORILAGIN

An ellagitannin with a hexahydroxydiphenoyl group bridging over the 3-O and 6-O of the glucose core.


An anthocyanin cation that is cyanidin attached to a 2''-O-galloyl-beta-D-galactopyranosyl residue at position 3 via a glycosidic linkage.


A  2-acyl-4-prenylphloroglucinol in which the acyl group is specified as 2-methylbutanoyl.


procyanidin B2 3'-O-gallate

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3'R)-hydroxy group of procyanidin B2.


A benzenetriol that is benzene-1,2,4-triol substituted by a (8Z,11Z)-heptadeca-8,11-dien-1-yl moiety at position 6.


deoxyhumulone

A 2-acyl-4,6-diprenylphloroglucinol in which the acyl group is specified as 3-methylbutanoyl.


procyanidin B1 3'-O-gallate

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3'S)-hydroxy group of procyanidin B1.


procyanidin B3 3-O-gallate

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3S)-hydroxy group of procyanidin B3.


epiafzelechin 3-gallate

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of epiafzelechin.


An aromatic ketone that is phloroglucinol in which two of the hydrogens attached to the benzene ring have been replaced by a chloro and hexanoyl groups. It is an intermediate biosynthetic precursor for differentiation-inducing factor 1 (DIF-1) which is a major inducer of stalk cell differentiation.


prunin 6''-O-gallate

A flavanone glycoside that is (2S)-flavanone substituted by hydroxy groups at positions 5 and 4', and a (6''-O-(3,4,5-trihydroxybenzoyl)-beta-D-glucopyranosyloxy residue at position 7.


An aromatic ketone that is phloroglucinol in which two of the hydrogens attached to the benzene ring have been replaced by chlorines while the third has been replaced by a hexanoyl group. It is the immediate biosynthetic precursor for differentiation-inducing factor 1 (DIF-1). DIF-1 is released by developing Dictyostelium amoebae, inducing them to differentiate into stalk cells.


epicatechin 3-O-(3'-O-methylgallate)

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of epicatechin.


gallate ester

A benzoate ester that is any ester resulting from the formal condensation of the carboxy group of gallic acid (3,4,5-trihydroxybenzoic acid) with an alcoholic or phenolic hydroxy group.


A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3S)-hydroxy group of (+)-epicatechin.


A benzenetriol that is benzophenone in which one of the phenyl groups is substituted at by hydroxy groups at positions 2, 4, and 6.


CATECHIN GALLATE

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3S)-hydroxy group of (+)-catechin.


A benzenetriol that is benzene-1,2,4-triol substituted by a (8Z)-pentadec-8-en-1-yl group at position 6.


THEASINENSIN A

A biflavonoid that is obtained by coupling of two molecules of (-)-epigallocatechin 3-gallate resulting in a bond between positions C-2 of the hydroxyphenyl ring. It is a natural product found in oolong tea.


okanin

A member of the class of  chalcones that is  trans-chalcone substituted by hydroxy groups at positions 3, 4, 2', 3', and 4' respectively.


phloroglucinol

A benzenetriol with hydroxy groups at position 1, 3 and 5.


epicatechin gallate

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of epicatechin. A natural product found in Parapiptadenia rigida.


A butan-4-olide that is gamma-valerolactone in which one of the methyl hydrogens has been replaced by a 3,4,5-trihydroxyphenyl group.


A benzenetriol that is acetophenone in which the hydrogens at positions 2, 4, and 6 on the phenyl group are replaced by hydroxy groups. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of acidic glycans and glycopeptides.


A 2-acylphloroglucinol in which the acyl group is specified as hexanoyl. It is the intermediate biosynthetic precursor for differentiation-inducing factor 1 (DIF-1).


A galloyl-beta-D-glucose compound having four galloyl groups in the 1-, 2-, 3- and 6-positions.


DEMETHYLXANTHOHUMOL

A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2', 4', and 6'  and a 3-methylbut-2-en-1-yl group at position 3'.


multifidol

A butanone that is the 2-methylbutanoyl derivative of phloroglucinol.


macabarterin

A ellagitannin isolated  from the stem bark of Macaranga barteri and has been shown to exhibit anti-inflammatory activity.


procyanidin B1 3-O-gallate

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of procyanidin B1.


procyanidin B2 3-O-gallate

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of procyanidin B2.


A galloyl-beta-D-glucose compound having two galloyl groups in the 1- and 6-positions.


rottlerin

A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.


GALLIC ACID METHYL ESTER

A gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties.


A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3'R)-hydroxy group of (-)-epicatechin-(4alpha->8)-(-)-epicatechin.


A gallate ester resulting from the formal condensation of gallic acid with 5-hydroxy group of (-)-epicatechin. Isolated from Orostachys japonica, it acts as an inhibitor of the enzyme mu-calpain (EC 3.4.22.52).


A benzenetriol that is benzene-1,2,4-triol substituted by a pentadecyl group at position 6.


A 2-acylphloroglucinol in which the acyl group is specified as 2-methylbutanoyl.


An aromatic ketone that is prenylphloroglucinol in which one of the two ring hydrogens has been replaced by an acyl group.


homoeriodictyol chalcone

A member of the class of  chalcones that is  trans-chalcone substituted by hydroxy groups at positions 4, 2', 4' and 6' and a methoxy group at position 3.


deoxyadlupulone

A 2-acyl-4,6-diprenylphloroglucinol in which the acyl group is specified as 2-methylbutanoyl.


MECLOFENAMATE SODIUM

A hydrate that is the monohydrate of the sodium salt of meclofenamic acid. It is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.


A 6-deoxyaltrose that is beta-D-altrofuranose in which the hydroxy group at position 6 has been replaced by a hydrogen.


Any  deoxyaltrose in which the hydroxy group at position 6 has been replaced by a hydrogen.


12,13-dihydroxyfumitremorgin C

An indole alkaloid  that is fumitremorgin C substituted at positions 12 and 13 by hydroxy groups.


name: multiple congenital anomalies-hypotonia-seizures syndrome


name: developmental and epileptic encephalopathy, 77


name: multiple congenital anomalies-hypotonia-seizures syndrome 3

description: A rare congenital disorder of glycosylation characterized by neonatal hypotonia, global development delay, developmental regress and severe to profound intellectual disability, infantile onset seizures that are initially associated with febrile episodes with subsequent transition to unprovoked seizures, impaired vision with esotropia and nystagmus, progressive cerebral and cerebellar atrophy, skeletal abnormalities (including brachycephaly, scoliosis, slender long bones, delayed bone age, pectus excavatum and osteopenia), inverted nipples and dysmorphic features including high and narrow forehead, frontal bossing, short nose, depressed nasal bridge, anteverted nares, high palate and wide open mouth consistent with facial hypotonia. Other features may include cardiac abnormalities (such as patent ductus arteriosus, atrial septal defects), urogenital abnormalities (such as nephrocalcinosis, urolithiasis), and low plasma concentration of alkaline phosphatase.


name: multiple congenital anomalies-hypotonia-seizures syndrome 2

description: Any multiple congenital anomalies/dysmorphic syndrome-intellectual disability in which the cause of the disease is a mutation in the PIGA gene.


LAMINARIPENTAOSE

A (1->3)-beta-D-glucan consisting of five D-glucosyl residues linked in a linear sequence.


An O-(S-acylpantetheine-4'-phosphoryl)serine(1-) residue in which the S-acyl group is specified as (2E)-hexadecenoyl.


apigenin 7-O-beta-L-glucoside

A glycosyloxyflavone that is apigenin substituted by a beta-L-glucopyranosyl moiety at position 7 via a glycosidic linkage.


substance P(3+)

A peptide cation obtained from the protonation of the amino and guanidino groups of substance P; major species at pH 7.3.


A glycotetraosylceramide having beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucose as the tetrasaccharide component.


erythromycin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of erythromycin.


polyketide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps.


F-9775A catabolic process

description: The chemical reactions and pathways resulting in the breakdown of F-9775A.


granaticin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of granaticin.


aspyridone A catabolic process

description: The chemical reactions and pathways resulting in the breakdown of aspyridone A.


aspyridone B catabolic process

description: The chemical reactions and pathways resulting in the breakdown of aspyridone B.


fonsecin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of fonsecin.


F-9775B catabolic process

description: The chemical reactions and pathways resulting in the breakdown of F-9775B.


averantin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of averantin.


oxytetracycline catabolic process

description: The chemical reactions and pathways resulting in the breakdown of oxytetracycline.


A linear heptasaccharide glycosyl group consisting of two N-acetylgalactosamine residues (one of which is disulfated at the 4-and 6-positions), two glucuronic acid residues and two galactosyl residues linked to a xylosyl residue at the reducing end.


Cranial Nerve II Palsy

description: Partial or complete paralysis of the optic nerve.


Non-Neoplastic Optic Nerve Disorder

description: A non-neoplastic disorder that affects the optic nerve.


Unilateral Optic Nerve Hypoplasia

description: A congenital abnormality characterized by the underdevelopment of one optic nerve.


sulfoglycochenodeoxycholic acid

A steroid sulfate that is the 3-O-sulfo derivative of glycochenodeoxycholic acid.


steroid sulfate

A sulfuric ester obtained by the formal condensation of a hydroxy group of any steroid with sulfuric acid.


clathsterol disulfonic acid

A steroid sulfate which is 16-hydroxystigmastane-2,3-diyl disulfonic acid that is substituted by a acetyloxy group at position 15 and by butanoyloxy groups at positions 22 and 23.


HALISTANOL SULFATE G

A steroid sulfate that is 5alpha-ergostane substituted by sulfate groups at positions 2, 3 and 6 (the (2beta,3alpha,6alpha stereoisomer).


2-hydroxy-17beta-estradiol 3-sulfate

A steroid sulfate that is 2-hydroxy-17beta-estradiol in which the phenolic hydrogen at position 3 has been replaced by a sulfo group.


21-hydroxypregnenolone disulfate

A steroid sulfate that is 21-hydroxypregnenolone in which both hydroxy hydrogens have been replaced by sulfo groups.


A steroid sulfate that is 5alpha-pregnane-3beta,20alpha-diol in which both hydroxy hydrogens have been replaced by sulfo groups.


name: sulfuric acid [(8R,9R,13S,14R)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] ester


testosterone sulfate

A steroid sulfate that is testosterone substituted by a sulfoxy group at position 17.


(24S)-hydroxycholesterol 24-sulfate

A steroid sulfate that is (24S)-24-hydroxycholesterol carrying a single sulfo substituent at the O-24 position.


A withanolide that is 2,3-dihydrowithaferin A substituted by a sulfoxy group at position 3. Isolated from Physalis longifolia, it exhibits antineoplastic activity.


androsterone sulfate

A steroid sulfate that is the 3-sulfate of androsterone.


(24S)-hydroxycholesterol 3-sulfate

A steroid sulfate that is (24S)-24-hydroxycholesterol carrying a single sulfo substituent at the O-3 position.


halistanol sulfonic acid F

A steroid sulfate with anti-HIV activity.


17alpha-ethynylestradiol 3-sulfate

A steroid sulfate that is 17alpha-ethynylestradiol in which the phenolic hydrogen at position 3 has been replaced by a sulfo group.


epiandrosterone sulfate

A steroid sulfate that is the 3-sulfate of epiandrosterone.


5beta-cyprinol sulfate

A steroid sulfate that is the sulfuric ester derivative of 5beta-cyprinol.


cortisol 21-sulfate

A steroid sulfate obtained by the formal condensation of hydroxy group at position 21 of cortisol with sulfuric acid.


A brassinosteroid that is 24-epi-cathasterone on which the hydroxy hydrogen at position 22 has been replaced by a sulfo group.


glycodeoxycholic acid 3-sulfate

A bile acid glycine conjugate that is glycodeoxycholic acid in which the hydroxy hydrogen at position 3 has been replaced by a sulfo group.


5alpha-dihydrotestosterone sulfate

A 3-oxo-5alpha-steroid that is 5alpha-dihydrotestosterone in which the hydroxy hydrogen at position 17 has been replaced by a sulfo group.


17beta-estradiol 17-sulfate

A steroid sulfate obtained by the formal condensation of sulfuric acid with the 17-hydroxy group of 17beta-estradiol.


WITHALONGOLIDE G

A  withanolide that is 2,3-dihydrowithaferin A substituted by a hydroxy group at position 19 and a sulfoxy group at position 3. Isolated from Physalis longifolia, it exhibits antineoplastic activity.


5alpha-pregnane-3,20beta-diol disulfate

A steroid sulfate that is 5alpha-pregnane-3,20beta-diol in which both hydroxy hydrogens have been replaced by sulfo groups.


(24S)-hydroxycholesterol 3,24-disulfate

A steroid sulfate that is (24S)-24-hydroxycholesterol in which both hydroxy hydrogens have been replaced by sulfo groups.


cholesterol sulphate

A steroid sulfate that is cholesterol substituted by a sulfoxy group at position 3.


name: sulfuric acid [(13S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] ester


sulfoglycolithocholic acid

The 3-O-sulfo derivative of glycolithocholic acid.


17alpha-hydroxypregnenolone 3-sulfate

A steroid sulfate that is 17alpha-hydroxypregnenolone in which the hydroxy hydrogen at position 3 has been replaced by a sulfo group.


A steroid sulfate that is 4-androstene-3beta,17beta-diol in which both hydroxy hydrogens have been replaced by sulfo groups.


lithocholic acid sulfate

A steroid sulfate that is lithocholic acid in which the hydroxy hydrogen at position 3 has been replaced by a sulfo group.


dehydroepiandrosterone sulphate

A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone.


cellular response to inositol

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inositol stimulus.


cyanate ester

Esters of cyanic acid, HOC#N.


cataract 33

description: Any early-onset non-syndromic cataract in which the cause of the disease is a mutation in the BFSP1 gene.


name: immunodeficiency, developmental delay, and hypohomocysteinemia


neuronal dense core vesicle membrane

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The lipid bilayer surrounding a neuronal dense core vesicle.


Multiple Solitary Plasmacytoma of Bone

description: The presence of more than one plasmacytoma arising in the bone, concurrently or sequentially, in the absence of bone marrow involvement by plasma cell myeloma.


chlorocycloalkane

A chlorohydrocarbon that is any cycloalkane substituted by at least one chloro group.


monochlorocyclohexane

A chlorocyclohexane carrying a single chloro group.


chlorocyclohexane

Any chlorocycloalkane that is cyclohexane substituted by at least one chlorine group.


BETA-HEXACHLOROCYCLOHEXANE

The beta-isomer of hexachlorocyclohexane.


Major species at pH 7.3.


A derivative of eugenol with methyl substituents at ring positions 3, 5 and 6.


squaric acid

A carbon oxoacid that consists of 1,2-diketocyclobut-3-ene bearing two enolic hydroxy substituents at positions 3 and 4.


A monovalent inorganic anion that consists of silicic acid in which one of the four OH groups has been deprotonated.


A trivalent inorganic anion obtained by removal of three protons from silicic acid.


A divalent inorganic anion obtained by removal of two protons from silicic acid.


ovarian microcystic stromal tumor

description: A benign, unilateral tumor that arises from the ovary and is characterized by the presence of conspicuous microcystic changes, cellular areas, and a fibrous stroma.


benign ovarian sex cord-stromal tumor

description: A sex cord-stromal tumor arising from the ovary, without metastatic potential.


ovarian fibrothecoma

description: A rare, benign, sex cord-stromal neoplasm, with a typically unilateral location in the ovary, characterized by mixed features of both fibroma and thecoma. Patients may be asymptomatic or may present with pelvic/abdominal pain and/or distension and, occasionally, with post-menopausal bleeding. Large tumors (>10cm) are often associated with pleural effusion and ascites (the Meigs syndrome triad).


phyllodes tumor

description: A benign, borderline, or malignant fibroepithelial neoplasm arising from the breast and rarely the prostate gland. It may recur following resection. The recurrence rates are higher for borderline and malignant phyllodes tumors. In borderline and malignant phyllodes tumors metastases to distant anatomic sites can occur. The incidence of metastases is higher in malignant phyllodes tumors.


prostate phyllodes tumor

description: An unusual, biphasic benign or malignant neoplasm that arises from the prostate gland. It is characterized by the presence of an epithelial glandular component and a proliferating stroma.


Borderline Vulvar Phyllodes Tumor

description: A rare borderline phyllodes tumor arising from the vulva.


benign prostate phyllodes tumor

description: A rare benign neoplasm that arises from the prostate gland and is characterized by the presence of hyperplastic glands and stroma that contains spindle-shaped cells.


Refractory Malignant Phyllodes Tumor

description: Malignant phyllodes tumor that is resistant to treatment.


name: Phyllodes Tumor of Anogenital Mammary-Type Glands

description: A rare phyllodes tumor that arises from mammary-like glands in the anogenital region.


Malignant Vulvar Phyllodes Tumor

description: A rare malignant phyllodes tumor arising from the vulva.


benign phyllodes tumor

description: A benign, circumscribed fibroepithelial neoplasm arising from the breast and rarely the prostate gland. It is characterized by the presence of epithelial structures which are arranged in clefts and by a hypercellular mesenchymal stroma which is organized in leaf-like structures. There is no evidence of cellular atypia or sarcomatous features.


malignant phyllodes tumor

description: A phyllodes tumor with sarcomatous stroma. The sarcomatous component is usually of the fibrosarcomatous type. Liposarcomatous, chondrosarcomatous, osteosarcomatous, or rhabdomyosarcomatous differentiation may also occur in the stroma. It may recur and metastasize following surgical resection. The lung and skeleton are the anatomic sites most frequently involved by metastases.


Benign Vulvar Phyllodes Tumor

description: A rare benign phyllodes tumor arising from the vulva.


Childhood Breast Phyllodes Tumor

description: A phyllodes tumor that arises from the breast and occurs during childhood.


Vulvar Phyllodes Tumor

description: A rare benign, borderline, or malignant phyllodes tumor arising from the vulva.


Borderline phyllodes tumor

description: A phyllodes tumor with morphologic characteristics which are intermediate between a benign and a malignant phyllodes tumor. The stromal sarcomatous changes are of low grade and are often reminiscent of low grade fibrosarcomas.


malignant prostate phyllodes tumor

description: An unusual malignant tumor that arises from the prostate gland. It is characterized by the presence of glandular elements and a cellular stroma that exhibits mitotic activity and nuclear atypia.


A branched amino pentasaccharide comprising a chain of alpha-N-acetylneuraminyl, N-acetyl-beta-D-glucosaminyl and beta-D-galactose residues linked sequentially (2->6) and (1->3), to the N-acetyl-beta-D-glucosaminyl residue of which is also attached via a beta(1->3) linkage an  N-acetyl-beta-D-galactosaminyl-(1->4)-D-galactosyl disaccharide side-chain. A 5-aminopentyl linker may be attached to the oxygen at position 1 of the reducing-end galactose residue.


validamycins

Any of the inositol-derived beta-D-glucoside antibiotics produced by Streptomyces hygroscopicus.


validamycin B

A member of the class of validamycins that is validamycin A in which the pro-R hydrogen at the unsubstituted position of the cycloxexane ring has been replaced by a hydroxy group.


VALIDAMYCIN

A member of the class of validamycins that is (1R,2S,3S,4S,6R)-4-amino-6-(hydroxymethyl)cyclohexane-1,2,3-triol in which the hydroxy group at position 1 has been converted to its beta-D-glucoside and in which one of the hydrogens attached to the nitrogen is replaced by a (1R,4R,5R,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl group. It is the major validamycin produced by Streptomyces hygroscopicus.


name: megalencephalic leukoencephalopathy with subcortical cysts 4, remitting


An organic cation that is the conjugate acid of lupanine, arising from protonation of the tertiary amino function; major species at pH 7.3.


name: paternal uniparental disomy of chromosome 7

description: Paternal uniparental disomy of chromosome 7 is an uniparental disomy of paternal origin that most likely do not have any phenotypic expression except from cases of homozygosity for a recessive disease mutation for which only father is a carrier (e.g., cystic fibrosis, congenital chloride diarrhea, sensorineural hearing loss).


spindle cell neoplasm

description: A benign or malignant neoplasm characterized by the presence of neoplastic spindle cells.


ciliary body spindle cell melanoma

description: A spindle cell melanoma that involves the ciliary body.


spindle cell lipoma

description: A benign circumscribed tumor composed of spindled cells, adipocytes, and collagen bundles. There is no evidence of nuclear hyperchromasia or mitotic activity.


iris spindle cell melanoma

description: A spindle cell melanoma that involves the iris.


desmoplastic melanoma

description: A melanoma of the skin characterized by a proliferation of atypical spindled melanocytes in the dermis, in a background of abundant collagen. It usually presents as an amelanotic raised nodular lesion.


malignant spindle cell neoplasm

description: A malignant neoplasm characterized by the presence of atypical spindle cells.


spindle cell melanoma

description: A melanoma characterized by the presence of malignant spindle-shaped melanocytes.


spindle cell intraocular melanoma

description: A melanoma arising from the choroid, ciliary body, or the iris. It is characterized by the presence of spindle-shaped melanocytes.


name: Complex Endometrial Hyperplasia with Atypia

description: A hyperplasia characterized by excessive proliferation of endometrial cells, resulting in the formation of complex epithelial structures.  It is associated with cytologic atypia and an increased risk of endometrial adenocarcinoma.


An L-alpha-amino acid residue residue derived from N(alpha)-gamma-L-glutamylhistamine


name: Ampulla of Vater Enterochromaffin Cell Serotonin-Producing Neuroendocrine Tumor

description: A well differentiated neuroendocrine tumor that arises from the ampulla of Vater and the periampullary region.  It produces serotonin.


4-ethylphenyl sulfate

An aryl sulfate that is 4-ethylphenol in which the hydroxy group has been replaced by a sulfooxy group.


name: Quercetin 3-methyl ether 7-alpha-L-arabinofuranosyl-(1->6)-glucoside


gonococcal cystitis

description: An cystitis caused by infection with Neisseria gonorrhoeae.


acute gonococcal cystitis

description: Acute form of gonococcal cystitis.


A member of the class of azetidines that is propylazetidine substituted by a 3-pyridyl group position 2 and a 4-toluenesulfonamido group at position 3.


name: acetic acid [2-(1-acetyl-6-indolyl)-2-oxoethyl] ester


name: endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

description: Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.


CLAPO syndrome

description: CLAPO syndrome is a newly described syndrome consisting of capillary malformation of the lower lip (C), lymphatic malformation of the face and neck (L), asymmetry of face and limbs (A) and partial or generalized overgrowth (O).


amine

A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.


(S)-clenbuterol

The (S)-enantiomer of clenbuterol.


naftifine

A tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections.


A pyridinium cation with a methyl substituent at the 1-position and a 4-(dihexadecylamino)styryl substituent at the 4-position.


A member of the class of  propanolamines that is propane with a hydroxy substituent at C-1 and an amino substituent at C-2, making it both a primary amine and a primary alcohol.


enaminone

A compound containing a conjugated system of an amine, an alkene and a ketone.


An alkylamine having isobutyl as the alkyl group. It has been isolated from Sambucus nigra (Elderberry).


A phenylalkylamine that is benzene in which one of the hydrogens is substituted by a 3-aminopentyl group.


(R)-dobutamine

The (R)-enantiomer of dobutamine.


7,8-diaminononanoic acid

An amino fatty acid carrying amino substituents at positions 7 and 8. Some of its isomers are naturally occurring intermediates of biotin synthesis, and targets of antimicrobial and herbicide development.


A primary aliphatic amine that is hexane substituted by an amino group at position 2.


Azobenzene substituted at one of the 4-positions by an amino group. It has a role as a dye and an allergen.


coelimycin P1

An organosulfur heterocyclic compound that is 1,5-oxathiocane which has been substituted at the 2-pro-R, 3, 6, and 8 positions by oxo, acetamido,  5,6-dihydropyridin-2(1H)-ylidene, and  (2E)-but-2-enoyl groups, respectively, and which has been dehydrogenated to introduce a double bond at the 7-8 position. It was isolated from Streptomyces coelicolor M145 after genetically engineered increase of the metabolic flux and is the product of a polyketide biosynthetic gene cluster.


A 6-carbon primary aliphatic amine.


FM 4-64(2+)

A pyridinium cation with a 3-(triethylammonio)propyl substituent at the 1-position and a 6-[4-(dibutylamino)phenyl]hexa-1,3,5-trien-1-yl substituent at the 4-position.


PENTADECYLAMINE

An alkylamine that is pentadecane substituted by an amino group at position 1.


pindolol

A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.


N-cyclohexyl-2-aminoethanesulfonic acid

An alkanesulfonic acid that is cyclohexanamine in which one of the amino hydrogens is substituted by a 2-sulfoethyl group. It is used as a buffer (pH range of 8.6-10.0) for studying pH-dependent processes in enzymology.


A primary amine of general formula RCH2CH2NH2 where R represents an aryl moiety.


An 8-carbon primary aliphatic amine.


PYRROLE

A tautomer of pyrrole that has the double bonds at positions 2 and 4.


clenbuterol

A substituted aniline that is 2,6-dichloroaniline in which the hydrogen at position 4 has been replaced by a 2-(tert-butylamino)-1-hydroxyethyl group.


enamine

An amine RNR'R'' where R has a double bond adjacent to the amine nitrogen.


A primary arylamine that is p-xylene substituted at the 2 and 5 positions by amino groups. It is formally a reduction product of 2,5-dimethyl-1,4-benzoquinonediimine.


terbinafine

A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections.


5-AMINOVALERIC ACID

A delta-amino acid comprising pentanoic acid with an amino substituent at C-5; a methylene homologue of gamma-aminobutyric acid (GABA) that is a weak GABA agonist.


memantine

A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.


A 2-arylethylamine compound where the aryl moiety is 4-bromo-2,5-dimethoxyphenyl.


A pyridinium cation with a methyl substituent at the 1-position and a 4-(dimethylamino)styryl substituent at the 2-position.


(-)-echitovenine

An Aspidosperma alkaloid that is (5alpha,12beta,19alpha)-2,3-didehydroaspidospermidine which is substituted by a methoxycarbonyl group at position 3 and by an acetoxy group at position 20.


The (S)-enantiomer of 2-phenylpropylamine.


Quinuclidine in which a hydrogen atom at position 3 is substituted by a hydroxy group.


9-aminononanoic acid

A omega-amino fatty acid that is nonanoic acid substituted by an amino group at position 9.


2-aminohexadecanoic acid

An alpha-amino fatty acid of chain length C16.


benethamine

An aromatic amine that is 2-phenylethanamine in which one of the hydrogens attached to the amino group is substituted by a benzyl group.


(Z)-2-aminobutenoic acid

A 2,3-dehydroamino acid resulting from the formal elimination of water from the side-chain of threonine.


cathine

An amphetamine that is propylbenzene substituted by a hydroxy group at position 1 and by an amino group at position 2 (the 1S,2S-stereoisomer).


An aralkylamine that is Nbenzylacetamidine substituted at position 3 on the benzene ring by an aminomethyl group. An inhibitor of nitric oxide synthase.


(S)-diethylpropion

The (S)-enantiomer of amfepramone.


(Z)-3-amino-2-methylacrylic acid

An alpha,beta-unsaturated monocarboxylic acid that is methacrylic acid (2-methylacrylic acid) in which the pro-Z hydrogen at the beta position has been replaced by an amino group.


naphthylamine

A primary arylamine that is naphthalene substituted by an amino group at unspecified position.


An amphetamine that is propylbenzene substituted by a hydroxy group at position 1 and by an amino group at position 2 (the 1S,2R-stereoisomer).


fexofenadine

A piperidine-based anti-histamine compound.


tripropylamine

A tertiary amine that is ammonia in which each hydrogen atom is substituted by a propyl group.


ROLICYCLIDINE

Pyrrolidine in which the hydrogen attached to the nitrogen is substituted by a 1-phenylcyclohex-1-yl group.


A primary aliphatic amine that is pentane substituted by an amino group at position 3. Metabolite observed in cancer metabolism.


N-methylcyclohexylamine

A secondary aliphatic amine having methyl and cyclohexyl as the two alkyl groups.


(+)-TRANYLCYPROMINE

A 2-phenylcyclopropan-1-amine that is the (1S,2R)-enantiomer of tranylcypromine.


An aminobiphenyl whose amino group is at C-4 and is hydroxylated at C-4'.


kitastatin 1

An 18-membered cyclodepsipeptide having a 3-amino-2-hydroxybenzoyl group attached to the amino terminus. It is isolated from an Alaskan Kitasatospora sp. and exhibits antineoplastic activity.


secondary amine

A compound formally derived from ammonia by replacing two hydrogen atoms by hydrocarbyl groups.


A member of the class of 1,4-benzoquinones that is 1,4-benzoquinone in which the hydrogens at positions 2 and 5 have been replaced by aziridin-1-yl groups while the hydrogens at positions 3 and 6 have been replaced by (2-hydroxyethyl)amino groups.


MEPHEDRONE

An aromatic ketone that is propiophenone substituted at C-4 and at C-beta with methyl and methylamino groups respectively. It is a synthetic stimulant and entactogen drug of the amphetamine and cathinone classes.


N,N-dimethylbutylamine

A tertiary amine consisting of n-butane having a dimethylamino substituent at the 1-position.


propranolol

A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.


bufotenine

A tertiary amine that consists of N,N-dimethyltryptamine bearing an additional hydroxy substituent at position 5.


indigoidine

A member of the class of pyridone that is a dimeric blue pigment biosynthesised from L-glutamine.


A racemate comprising equimolar amounts of (R)- and (S)-3,4-methylenedioxy-N-ethylamphetamine3,4-methylenedioxy-N-ethylamphetamine.


tridodecylamine

A tertiary amine consisting of three dodecyl groups attached to a central nitrogen.


A propanoate ester that is propyl propanoate substituted by a benzyl and phenyl group at position 1, a methyl group at position 2 and a dimethylamino group at position 3.


PAP

A glycol that is a derivative of glycerol in which one of the hydroxy groups is replaced by an anilino group.


beta-amino-fatty acid

A fatty acid with an amino substituent at position C-3; constituent of iturinic antibiotics.


primary arylamine

A primary amine formally derived from ammonia by replacing one hydrogen atom by an aryl group. R-NH2 where R is an aryl group.


A primary aliphatic amine that is ethane-1,2-diamine substituted by an isopropyl group at the N atom.


flupyradifurone

A tertiary amino compound that is ammonia in which the nitrogens have been replaced by (6-chloropyridin-3-yl)methyl, 2,2-difluoroethyl, and 5-oxo-2,5-dihydrofuran-3-yl groups, respectively. A nicotinic acetylcholine receptor (AChR) agonist, it is used as an insecticide to control sucking pests in a variety of crops.


aralkylamine

An alkylamine in which the alkyl group is substituted by an aromatic group.


4-aminoazobenzene-3,4'-disulfonic acid

A member of the class of azobenzenes that is azobenzene in which one of the phenyl groups is substituted at the para position by a sulfo group, while the other is substituted at a meta position by a sulfo group and at the para position by an amino group. The disodium salt is the biological stain 'fast yellow'.


dexamfetamine

A 1-phenylpropan-2-amine that has S configuration.


PROPYLAMINE

A member of the class of  alkylamines that is propane substituted by an amino group at C-1.


amphetamine

A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.


An  aromatic ether that is the derivative of 2-phenylethylamine with methoxy substituents at the 3- and 4-positions. It is an alkaloid isolated from the Cactaceae family.


A primary amino compound that is propan-1-amine which carries a phenyl group at position 1.


isoamylamine

A primary aliphatic amine that is butan-1-amine carrying a methyl substituent at position 3.


benzphetamine

Dextroamphetamine in which the the hydrogens attached to the amino group are substituted by a methyl and a benzyl group. A sympathomimetic agent with properties similar to dextroamphetamine, it is used as its hydrochloride salt in the treatment of obesity.


dicyclomine

The ester resulting from the formal condensation of 1-cyclohexylcyclohexanecarboxylic acid with 2-(diethylamino)ethanol. An anticholinergic, it is used as the hydrochloride to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome.


name: 2-[4-[[4-(dimethylamino)phenyl]methylidene]-5-oxo-1-phenyl-3-pyrazolyl]acetic acid ethyl ester


Azobenzene substituted at each of the phenyl 4-positions by an amino group.


diethylpropion

An  aromatic ketone that is propiophenone in which one of the hydrogens alpha- to the carbonyl is substituted by a diethylamino group. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as the hydrochloride as an anoretic in the short term management of obesity.


gallamine

A tertiary amine non-depolarising muscle relaxant whose structure comprises a core benzene molecule substituted at each of C-1, C-2 and C-3 by an N,N-diethyl-2-(ethylamino)ethoxy group.


dobutamine

A  catecholamine that is 4-(3-aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used as the hydrochloride to increase the contractility of the heart in the management of acute heart failure.


nortriptyline

An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of  amitriptyline.


dioctylamine

A secondary amine in which the two alkyl substituents are specified as octyl.


aminobiphenyl

Any member of the class of biphenyls in which the biphenyl skeleton is substituted by at least one amino group.


6-aminocaproic acid

An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.


TERT-BUTYLAMINE

A primary aliphatic amine that is ethylamine substituted by two methyl groups at position 1.


levdobutamine

The (S)-enantiomer of dobutamine.


mercaptamine

An amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2.


tranylcypromine

A 2-phenylcyclopropan-1-amine that is the (1R,2S)-enantiomer of tranylcypromine.


3-aminooctanoic acid

A beta-amino acid that is caprylic acid which is substituted by an amino group at position 3.


SYBR Green I

A benzothiazolium ion resulting from the methylation of the nitrogen of the benzothiazole group of N-[4-(1,3-benzothiazol-2-ylmethylene)-1-phenyl-1,4-dihydroquinolin-2-yl]-N',N'-dimethyl-N-propylpropane-1,3-diamine. A cationic unsymmetrical cyanine dye that binds to double-stranded DNA and is used as a nucleic acid stain in molecular biology.


nintedanib

A member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer.


A 24-membered macrolide antibiotic isolated from the fermentation broth of Streptomyces sp.NK154183. It exhibits antifungal and antitumour activity against the human colon adenocarcinoma.


neticonazole

An enamine that is ethene which is substituted at positions 1, 1, and 2 by o-pentoxyphenyl, 1H-imidazol-1-yl, and methylthio groups, respectively (the E isomer). An inhibitor of P450-dependent C-14alpha-demethylation of lanosterol (preventing conversion to ergosterol and inhibiting cell wall synthesis in fungi), it is used in Japan (generally as the corresponding hydrochloride salt) as an antifungal drug for the treatment of superficial skin infections.


perquinoline A

A perquinoline that is 8-amino 20-N-butanoic acid.


The (R)-enantiomer of 2-phenylpropylamine.


BENZYLAMINE

A primary amine compound having benzyl as the N-substituent. It has been isolated from  Moringa oleifera (horseradish tree).


A ring assembly that is the 2-(2,4-dibromophenyl) derivative of 4-[1-(benzylamino)ethylidene]-5-methyl-2,4-dihydropyrazol-3-one.


amitriptyline

An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.


malachite green isothiocyanate cation

The iminium cation of malachite green isothiocyanate.


A primary amine comprising an octane skeleton with amino substituents at carbon positions 1 and 8; and an aminomethyl substituent at position 5.


N-methylaniline

A methylaniline that is  aniline carrying a methyl substituent at the nitrogen atom.


chloridazone-methyl-desphenyl

A pyridazinone that is pyridazin-3(2H)-one substituted by an amino group at position 5, a chloro group at position 4 and a methyl group at position 2. It is a metabolite of the herbicide chloridazone.jfuyklriltoil


methoxyphenamine

An amphetamine methylated on nitrogen and with the phenyl ring methoxylated at C-2. A beta-adrenergic receptor agonist, it is used as a bronchodilator.


A secondary aliphatic amine with two undecyl groups


ANILINE

A primary arylamine in which an amino functional group is substituted for one of the benzene hydrogens.


(2R)-aminoheptanoic acid

An alpha-amino fatty acid that is heptanoic acid substituted by an amino group at position 2 (the 2R stereoisomer).


myriocin

An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity.


An ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals.


A C-nitro compound that is a stilbene derivative having an N-methyl,N-5-carboxypentylamino group at the 4-position and a nitro substituent at the 4'-position.


celesticetin

A lincosamide antibiotic produced in Streptomyces caelestis.


diethyl(propyl)amine

A tertiary amine that is propylamine in which the two amino hydrogens are replaced by ethyl groups.


secodine

A methyl ester that is 1H-indole substituted by a 3-methoxy-3-oxoprop-1-en-2-yl group at position 2 and a 2-(5-ethyl-3,4-dihydropyridin-1(2H)-yl)ethyl groups at position 3. It is a transient intermediate in the synthesis of indole alkaloids such as vindoline and vincadifformine.


alverine

A tertiary amine having one ethyl and two 3-phenylprop-1-yl groups attached to the nitrogen. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used (particularly as the citrate salt) in the treatment of irritable bowel syndrome.


N-methylbutylamine

A secondary aliphatic amine having methyl and n-butyl as the two alkyl groups.


METHOXYPHENAMINE HYDROCHLORIDE

The hydrochloride salt of methoxyphenamine, a beta-adrenergic receptor agonist that regulates norephinephrine and ephinephrinein concentrations.


MDMA

A member of the class of  benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.


bacillaene

A polyene antibiotic obtained from Bacillus subtilis 168 that is active against a broad spectrum of bacteria. It is notoriously unstable.


methoxamine

An amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group and the phenyl ring is 2- and 5-substituted with methoxy groups. It is an antihypotensive agent (pressor), an agonist acting directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine .


vibegron

A pyrrolopyrimidine obtained by formal condensation of the carboxy group of (6S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylic acid with the amino group of (R)-[(2R,5S)-5-(4-aminobenzyl)pyrrolidin-2-yl](phenyl)methanol. It is a beta3-adrenergic receptor agonist currently in clinical development for the treatment of patients with overactive bladder.


(R)-fenpropidin

A 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine that has R configuration.


perquinoline B

A perquinoline that is 8-amino 20-N-propanoic acid.


lumefantrine

A member of the class of fluorenes that is 9-(p-chlorobenzylidene)-9H-fluorene which is substitutec by chlorine at positions 2 and 7, and by a 2-(dibutylamino)-1-hydroxyethyl group at position 4. An antimalarial drug used in combination with artemether for the treatment of multi-drug resistant strains of falciparum malaria.


A derivative of aniline in which the hydrogen at position 3 has been substituted by fluorine. It is used as a pharmaceutical intermediate.


The N-(4-aminobutyl) derivative of 3-aminopropanal.


A phenylethylamine that is ethylamine substituted by a phenyl group at position 1.


A primary aliphatic amine that is n-pentane in which a hydrogen of one of the methyl groups is replaced by an amino group. A water-soluble liquid with boiling point 104degreeC, it is a strong irritant.


p-Ts-L-Lys-Me

A methyl ketone that is L-lysine with an alpha-amine hydrogen substituted with a 4-methylbenzenesulfonamide (tosyl) group and a methyl group replacing the hydroxy of the carboxylic acid.


A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a 2-aminophenyl group at position 2.


alkylamine

Any primary amine in which the substituent attached to nitrogen is an alkyl group.


difenoxin

A piperidinemonocarboxylic acid that is 4-phenylpiperidine-4-carboxylic acid in which the hydrogen attached to the nitrogen atom is substituted by a 3-cyano-3,3-diphenylpropyl group.


NAPHTHYLAMINE

A naphthylamine carrying the amino group at position 2.


An amphetamine that is propylbenzene substituted by a hydroxy group at position 1 and by an amino group at position 2 (the 1R,2S-stereoisomer). It is a plant alkaloid.


A phenylalkylamine that is propan-1-amine substituted by a phenyl group at position 2. It is classified as a doping agent by the World Anti-Doping Agency.


A  primary arylamine that is the derivative of aniline in which the hydrogen at position 4 has been substituted by fluorine. It is used as an intermediate in the manufacture of pharmaceuticals, herbicides and plant growth regulators.


lopinavir

A dicarboxylic acid diamide that is amphetamine is substituted on nitrogen by a (2,6-dimethylphenoxy)acetyl group and on the carbon alpha- to nitrogen by a (1S,3S)-1-hydroxy-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1-yl)butanoyl]amino}-4-phenylbutyl group. An antiretroviral of the protease inhibitor class, it is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir.


hesperadin

An oxindole that is indolin-2-one which is substituted at position 5 by an (ethylsulfonyl)nitrilo group and at position 2 by a methylidene group, which is itself substituted by a phenyl group and a [4-(piperidin-1-ylmethyl)phenyl]amino group. An Aurora B kinase inhibitor, it is used to inhibit chromosome alignment and segregation.


LUPANINE

The delta-lactam obtained by formal oxidation at the 2-position of sparteine. The major alkaloid from the seeds of Lupinus exaltatus, L. mexicanus and L. rotundiflorus, it is among the most important of the tetracyclic quinolizidine alkaloids.


(R)-clenbuterol

The (R)-enantiomer of clenbuterol.


bepridil

A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.


rasagiline

An indane that consists of 1-aminoindane bearing an N-propargyl substituent. A selective, irreversible monoamine oxidase-B inhibitor.


Azobenzene substituted at the phenyl 4-positions by an amino and a nitro group.


tranylcypromine

A member of the class of cyclopropanes carrying amino and phenyl substituents at positions 1 and 2 respectively.


An acetylenic compound that is 2,2-tetramethyl-3-hexyn-1-amine in which both amino hydrogens have been replaced by methyl groups.


An aza-steroid that is 5beta-cholestane in which the carbon at position 25 is replaced by a nitrogen. It inhibits sitosterol-to-cholesterol conversion in Caenorhabditis elegans.


A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by an amino group at position 2, 3,5-dimethoxyphenyl group at position 6, and by a (tert-butylcarbamoyl)nitrilo group at position 7. It is a selective ATP competitive inhibitor of the human fibroblast growth factor-1 receptor (FGFR1) tyrosine kinase with an IC50 of 52.4 nM.


N,N-dimethylaniline

A tertiary amine that is aniline in which the amino hydrogens are replaced by two methyl groups.


A primary aliphatic amine that is pentan-3-amine substituted by methyl groups at positions 2 and 4. Metabolite observed in cancer metabolism.


A monocarboxylic acid that is but-2-enoic acid in which one of the hydrogens at position 4 is substituted by a [(E)-(5-oxo-2-phenyl-1,3-oxazol-4(5H)-ylidene)methyl]amino moiety.


A  primary arylamine that is aniline in which the hydrogens at the 3- and 4-positions are replaced by methyl groups. A low-melting, crystalline solid, it is used in the production of vitamin B2, dyes, pesticides and other chemicals.


dimethylthiambutene

N,N-Dimethylbut-3-en-2-amine in which each of the hydrogens at position 4 is substituted by a 2-thienyl group. An opioid analgesic drug, it is controlled under the UN Single Convention on Narcotic Drugs (1961), but is used in veterinary medicine, particularly in Japan.


METHYLAMINE

The simplest of the methylamines, consisting of ammonia bearing a single methyl substituent.


DIETHYLAMINE

A secondary aliphatic amine where both N-substituents are ethyl.


A naphthylamine that is naphthalene substituted by an amino group at position 1.


amino fatty acid

A fatty acid containing at least one amino substituent.