name: quizartinib-resistant FLT3 mutants (Homo sapiens)


name: quizartinib-resistant FLT3 mutants don't bind quizartinib (Homo sapiens)

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: gilteritinib-resistant FLT3 mutants (Homo sapiens)

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: gilteritinib-resistant FLT3 mutants don't bind gilteritinib (Homo sapiens)


name: lestaurtinib-resistant FLT3 mutants (Homo sapiens)


name: lestaurtinib-resistant FLT3 mutants don't bind lestaurtinib (Homo sapiens)


name: sorafenib-resistant FLT3 mutants (Homo sapiens)


name: sorafenib-resistant FLT3 mutants don't bind sorafenib (Homo sapiens)


name: tamatinib-resistant FLT3 mutants (Homo sapiens)


name: tamatinib-resistant FLT3 mutants don't bind tamatinib (Homo sapiens)


name: tandutinib-resistant FLT3 mutants (Homo sapiens)


name: tandutinib-resistant FLT3 mutants don't bind tandutinib (Homo sapiens)


name: pexidartinib-resistant FLT3 mutants (Homo sapiens)


name: pexidartinib-resistant FLT3 mutants don't bind pexidartinib (Homo sapiens)


name: sunitinib-resistant FLT3 mutants (Homo sapiens)


name: sunitinib-resistant FLT3 mutants don't bind sunitinib (Homo sapiens)


name: midostaurin-resistant FLT3 mutants (Homo sapiens)


name: midostaurin-resistant FLT3 mutants don't bind midostaurin (Homo sapiens)


name: KW2449-resistant FLT3 mutants (Homo sapiens)


name: KW2449-resistant FLT3 mutants don't bind KW2449 (Homo sapiens)


name: Signaling by ERBB2 TMD/JMD mutants (Homo sapiens)


name: ERBB2 TMD/JMD heterodimers trans-autophosphorylate (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1 (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1 (Homo sapiens)


name: RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR (Homo sapiens)


name: RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants (Homo sapiens)


name: Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1 (Homo sapiens)


name: ERBB2 TMD/JMD mutants bind TKIs (Homo sapiens)


name: ERBB2 TMD/JMD mutants bind pertuzumab (Homo sapiens)


name: ERBB2 TMD/JMD mutants bind trastuzumab (Homo sapiens)


name: ERBB2 TMD/JMD mutants hetrodimerize (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1 (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)


name: Signaling by ERBB2 KD Mutants (Homo sapiens)


name: RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR (Homo sapiens)


name: ERBB2 KD mutants bind trastuzumab (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1 (Homo sapiens)


name: ERBB2 KD mutants heterodimerize (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 (Homo sapiens)


name: PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 (Homo sapiens)


name: RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants (Homo sapiens)


name: ERBB2 KD mutants bind TKIs (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind PLCG1 (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1 (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)


name: ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)


name: PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)


name: Signaling by ERBB2 ECD mutants (Homo sapiens)


name: ERBB2 ECD mutants heterodimerize with EGFR (Homo sapiens)


name: Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)


name: ERBB2 ECD mutants bind TKIs (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1  (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K (Homo sapiens)


name: RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 (Homo sapiens)


name: GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1 (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)


name: RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 (Homo sapiens)


name: ERBB2 ECD mutants bind trastuzumab (Homo sapiens)


name: Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1 (Homo sapiens)


name: PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)


name: Drug resistance in ERBB2 TMD/JMD mutants (Homo sapiens)


name: ERBB2 TMD/JMD mutants do not bind pertuzumab (Homo sapiens)


name: Resistance of ERBB2 KD mutants to lapatinib (Homo sapiens)


name: Resistant ERBB2 KD mutants do not bind lapatinib (Homo sapiens)


name: Resistance of ERBB2 KD mutants to AEE788 (Homo sapiens)


name: Resistant ERBB2 KD mutants do not bind AEE788 (Homo sapiens)


name: Resistance of ERBB2 KD mutants to trastuzumab (Homo sapiens)


name: Resistant ERBB2 KD mutants do not bind trastuzumab (Homo sapiens)


name: Resistance of ERBB2 KD mutants to afatinib (Homo sapiens)


name: ERBB2 T798M does not bind afatinib (Homo sapiens)


name: Resistance of ERBB2 KD mutants to osimertinib (Homo sapiens)


name: ERBB2 KD mutants do not bind osimertinib (Homo sapiens)


name: Resistance of ERBB2 KD mutants to neratinib (Homo sapiens)


name: Resistant ERBB2 KD mutants do not bind neratinib (Homo sapiens)


name: Resistance of ERBB2 KD mutants to tesevatinib (Homo sapiens)


name: ERBB2 T733I does not bind tesevatinib (Homo sapiens)


name: Resistance of ERBB2 KD mutants to sapitinib (Homo sapiens)


name: ERBB2 T862A does not bind sapitinib (Homo sapiens)


name: Constitutive Signaling by Overexpressed ERBB2 (Homo sapiens)


name: ERBB2 homodimer phosphorylates SHC1 (Homo sapiens)


name: Trans-autophosphorylation of ERBB2 homodimer (Homo sapiens)


name: SHC1 binds phosphorylated ERBB2 homodimer (Homo sapiens)


name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1 (Homo sapiens)


name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer (Homo sapiens)


name: Signaling by LTK in cancer (Homo sapiens)


name: CLIP1-LTK promotes MAPK1 and MAPK3 phosphorylation (Homo sapiens)


name: CLIP1-LTK fusion binds PI3K to activate AKT (Homo sapiens)


name: CLIP1-LTK fusion autophosphorylates (Homo sapiens)


name: CLIP1(1-1083)-LTK(488-864) fusion dimerizes (Homo sapiens)


name: Active LTK binds GRB2:TNK2 (Homo sapiens)


name: Active LTK receptor binds PI3K (Homo sapiens)


name: Autophosphorylation of LTK dimer:ALKAL1,2 (Homo sapiens)


name: Active LTK receptor phosphorylates SHC1 (Homo sapiens)


name: Active LTK phosphorylates IRS1 (Homo sapiens)


name: Active LTK recruits GRB2:SOS1 (Homo sapiens)


name: IRS1 recruits GRB2 to active LTK (Homo sapiens)


name: Active LTK receptor binds SHC1 (Homo sapiens)


name: IRS1 recruits GRB2 to active LTK (Mus musculus)


name: Autophosphorylation of LTK dimer:ALKAL1,2 (Mus musculus)


name: Active LTK binds GRB2:TNK2 (Mus musculus)


name: Active LTK receptor phosphorylates SHC1 (Mus musculus)


name: Active LTK receptor binds SHC1 (Mus musculus)


name: Active LTK recruits GRB2:SOS1 (Mus musculus)


name: Active LTK phosphorylates IRS1 (Mus musculus)


name: Active LTK receptor binds PI3K (Mus musculus)


name: Active LTK binds GRB2:TNK2 (Rattus norvegicus)


name: Active LTK receptor binds SHC1 (Rattus norvegicus)


name: Active LTK recruits GRB2:SOS1 (Rattus norvegicus)


name: Active LTK receptor phosphorylates SHC1 (Rattus norvegicus)


name: Active LTK binds IRS1 (Rattus norvegicus)


name: LTK binds ALKAL ligand (Rattus norvegicus)


name: Active LTK phosphorylates IRS1 (Rattus norvegicus)


name: Active LTK receptor binds PI3K (Rattus norvegicus)


name: IRS1 recruits GRB2 to active LTK (Rattus norvegicus)


name: Autophosphorylation of LTK dimer:ALKAL1,2 (Rattus norvegicus)


name: Active LTK receptor binds PI3K (Danio rerio)


name: Autophosphorylation of LTK dimer:ALKAL1,2 (Danio rerio)


name: Active LTK binds IRS1 (Xenopus tropicalis)


name: Active LTK recruits GRB2:SOS1 (Xenopus tropicalis)


name: LTK binds ALKAL ligand (Xenopus tropicalis)


name: IRS1 recruits GRB2 to active LTK (Xenopus tropicalis)


name: Active LTK phosphorylates IRS1 (Xenopus tropicalis)


name: Active LTK receptor binds PI3K (Xenopus tropicalis)


name: Active LTK binds GRB2:TNK2 (Xenopus tropicalis)


name: Active LTK receptor phosphorylates SHC1 (Xenopus tropicalis)


name: Autophosphorylation of LTK dimer:ALKAL1,2 (Xenopus tropicalis)


name: Active LTK binds GRB2:TNK2 (Gallus gallus)


name: Autophosphorylation of LTK dimer:ALKAL1,2 (Gallus gallus)


name: IRS1 recruits GRB2 to active LTK (Gallus gallus)


name: Active LTK receptor phosphorylates SHC1 (Gallus gallus)


name: Active LTK recruits GRB2:SOS1 (Gallus gallus)


name: Active LTK receptor binds SHC1 (Gallus gallus)


name: Active LTK phosphorylates IRS1 (Gallus gallus)


name: Active LTK receptor binds PI3K (Gallus gallus)


name: PTEN Loss of Function in Cancer (Homo sapiens)


name: PTEN cancer mutants do not dephosphorylate PIP3 (Homo sapiens)


name: Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)


name: AKT1 E17K mutant phosphorylates forkhead box transcription factors (Homo sapiens)


name: AKT1 E17K mutant phosphorylates RSK (Homo sapiens)


name: AKT1 E17K mutant phosphorylates GSK3 (Homo sapiens)


name: AKT1 E17K mutant translocates to the nucleus (Homo sapiens)


name: AKT1 E17K mutant phosphorylates CREB1 (Homo sapiens)


name: AKT1 E17K mutant phosphorylates caspase-9 (Homo sapiens)


name: AKT1 E17K mutant binds PIP2 (Homo sapiens)


name: AKT1 E17K mutant phosphorylates NR4A1 (NUR77) (Homo sapiens)


name: AKT inhibitors block AKT membrane recruitment (Homo sapiens)


name: AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) (Homo sapiens)


name: AKT1 E17K mutant phosphorylates TSC2, inhibiting it (Homo sapiens)


name: AKT1 E17K mutant phosphorylates MDM2 (Homo sapiens)


name: AKT1 E17K mutant phosphorylates CHUK (IKKalpha) (Homo sapiens)


name: AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 (Homo sapiens)


name: PDPK1 phosphorylates AKT1 E17K mutant (Homo sapiens)


name: PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 (Homo sapiens)


name: AKT1 E17K mutant phosphorylates BAD (Homo sapiens)


name: AKT1 E17K mutant is phosphorylated by TORC2 complex (Homo sapiens)


name: Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)


name: PI3K inhibitors block PI3K catalytic activity (Homo sapiens)


name: PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)


name: Hh mutants are degraded by ERAD (Homo sapiens)


name: Hh processing variants are translocated to the cytosol in a VCP-dependent manner (Homo sapiens)


name: HPE SHH variants don't undergo autoproteolytic cleavage (Homo sapiens)


name: Hh processing variants are recruited to SEL1:SYVN at the ER membrane (Homo sapiens)


name: Hh processing variants are ubiquitinated (Homo sapiens)


name: Hh processing variants bind lectins (Homo sapiens)


name: processing defective Hh variants are degraded by the proteasome (Homo sapiens)


name: Hedgehog ligand biogenesis (Homo sapiens)


name: SYVN1 ubiquitinates Hh C-terminal fragments (Homo sapiens)


name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)


name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Homo sapiens)


name: HHAT palmitoylates Hh N-terminal fragment (Homo sapiens)


name: Autoproteolytic cleavage of Hh precursors (Homo sapiens)


name: C-terminal Hh fragments are bound by lectins (Homo sapiens)


name: Hh-Np traffics to the plasma membrane (Homo sapiens)


name: Hh C-terminal fragments are degraded by the proteasome (Homo sapiens)


name: P4HB forms mixed disulphides with Hh precursors (Homo sapiens)


name: Release of Hh-Np from the secreting cell (Homo sapiens)


name: Hh-Np is cleaved by ADAM17 to promote ligand shedding (Homo sapiens)


name: NOTUM releases Hh-Np:GPC5 from the plasma membrane (Homo sapiens)


name: Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Homo sapiens)


name: Release of Hh-Np from the secreting cell (Mus musculus)


name: Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Mus musculus)


name: NOTUM releases Hh-Np:GPC5 from the plasma membrane (Mus musculus)


name: Release of Hh-Np from the secreting cell (Rattus norvegicus)


name: Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Rattus norvegicus)


name: NOTUM releases Hh-Np:GPC5 from the plasma membrane (Rattus norvegicus)


name: Release of Hh-Np from the secreting cell (Canis familiaris)


name: Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Canis familiaris)


name: NOTUM releases Hh-Np:GPC5 from the plasma membrane (Canis familiaris)


name: Release of Hh-Np from the secreting cell (Bos taurus)


name: NOTUM releases Hh-Np:GPC5 from the plasma membrane (Bos taurus)


name: Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Bos taurus)


name: Release of Hh-Np from the secreting cell (Sus scrofa)


name: NOTUM releases Hh-Np:GPC5 from the plasma membrane (Sus scrofa)


name: Release of Hh-Np from the secreting cell (Danio rerio)


name: NOTUM releases Hh-Np:GPC5 from the plasma membrane (Danio rerio)


name: Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Danio rerio)


name: Release of Hh-Np from the secreting cell (Xenopus tropicalis)


name: Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Xenopus tropicalis)


name: Release of Hh-Np from the secreting cell (Gallus gallus)


name: NOTUM releases Hh-Np:GPC5 from the plasma membrane (Gallus gallus)


name: Release of Hh-Np from the secreting cell (Drosophila melanogaster)


name: Hh-Np binds GPC5 (Drosophila melanogaster)


name: NOTUM releases Hh-Np:GPC5 from the plasma membrane (Drosophila melanogaster)


name: Hedgehog ligand biogenesis (Mus musculus)


name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Mus musculus)


name: HHAT palmitoylates Hh N-terminal fragment (Mus musculus)


name: C-terminal Hh fragments are bound by lectins (Mus musculus)


name: Autoproteolytic cleavage of Hh precursors (Mus musculus)


name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Mus musculus)


name: SYVN1 ubiquitinates Hh C-terminal fragments (Mus musculus)


name: Hh C-terminal fragments are degraded by the proteasome (Mus musculus)


name: P4HB forms mixed disulphides with Hh precursors (Mus musculus)


name: Hh-Np traffics to the plasma membrane (Mus musculus)


name: Hedgehog ligand biogenesis (Rattus norvegicus)


name: Autoproteolytic cleavage of Hh precursors (Rattus norvegicus)


name: HHAT palmitoylates Hh N-terminal fragment (Rattus norvegicus)


name: C-terminal Hh fragments are bound by lectins (Rattus norvegicus)


name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Rattus norvegicus)


name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Rattus norvegicus)


name: P4HB forms mixed disulphides with Hh precursors (Rattus norvegicus)


name: Hh C-terminal fragments are degraded by the proteasome (Rattus norvegicus)


name: SYVN1 ubiquitinates Hh C-terminal fragments (Rattus norvegicus)


name: Hh-Np traffics to the plasma membrane (Rattus norvegicus)


name: Hedgehog ligand biogenesis (Canis familiaris)


name: HHAT palmitoylates Hh N-terminal fragment (Canis familiaris)


name: C-terminal Hh fragments are bound by lectins (Canis familiaris)


name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Canis familiaris)


name: Autoproteolytic cleavage of Hh precursors (Canis familiaris)


name: Hh C-terminal fragments are degraded by the proteasome (Canis familiaris)


name: Hh-Np traffics to the plasma membrane (Canis familiaris)


name: P4HB forms mixed disulphides with Hh precursors (Canis familiaris)


name: SYVN1 ubiquitinates Hh C-terminal fragments (Canis familiaris)


name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Canis familiaris)


name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Bos taurus)


name: C-terminal Hh fragments are bound by lectins (Bos taurus)


name: HHAT palmitoylates Hh N-terminal fragment (Bos taurus)


name: SYVN1 ubiquitinates Hh C-terminal fragments (Bos taurus)


name: Autoproteolytic cleavage of Hh precursors (Bos taurus)


name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Bos taurus)


name: P4HB forms mixed disulphides with Hh precursors (Bos taurus)


name: Hh C-terminal fragments are degraded by the proteasome (Bos taurus)


name: Hh-Np traffics to the plasma membrane (Bos taurus)


name: Hh C-terminal fragments are degraded by the proteasome (Sus scrofa)


name: Hh-Np traffics to the plasma membrane (Sus scrofa)


name: SYVN1 ubiquitinates Hh C-terminal fragments (Sus scrofa)


name: Autoproteolytic cleavage of Hh precursors (Sus scrofa)


name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Sus scrofa)


name: C-terminal Hh fragments are bound by lectins (Sus scrofa)


name: HHAT palmitoylates Hh N-terminal fragment (Sus scrofa)


name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Sus scrofa)


name: P4HB forms mixed disulphides with Hh precursors (Sus scrofa)


name: Hedgehog ligand biogenesis (Danio rerio)


name: SYVN1 ubiquitinates Hh C-terminal fragments (Danio rerio)


name: P4HB forms mixed disulphides with Hh precursors (Danio rerio)


name: Autoproteolytic cleavage of Hh precursors (Danio rerio)


name: Hh-Np traffics to the plasma membrane (Danio rerio)


name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Danio rerio)


name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Danio rerio)


name: Hh C-terminal fragments are degraded by the proteasome (Danio rerio)


name: C-terminal Hh fragments are bound by lectins (Danio rerio)


name: Hedgehog ligand biogenesis (Xenopus tropicalis)


name: C-terminal Hh fragments are bound by lectins (Xenopus tropicalis)


name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Xenopus tropicalis)


name: HHAT palmitoylates Hh N-terminal fragment (Xenopus tropicalis)


name: Autoproteolytic cleavage of Hh precursors (Xenopus tropicalis)


name: SYVN1 ubiquitinates Hh C-terminal fragments (Xenopus tropicalis)


name: Glycosylation of Hh (Xenopus tropicalis)


name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Xenopus tropicalis)


name: Hh-Np traffics to the plasma membrane (Xenopus tropicalis)


name: P4HB forms mixed disulphides with Hh precursors (Xenopus tropicalis)


name: Hedgehog ligand biogenesis (Gallus gallus)


name: Autoproteolytic cleavage of Hh precursors (Gallus gallus)


name: Hh-Np traffics to the plasma membrane (Gallus gallus)


name: P4HB forms mixed disulphides with Hh precursors (Gallus gallus)


name: C-terminal Hh fragments are bound by lectins (Gallus gallus)


name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Gallus gallus)


name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Gallus gallus)


name: HHAT palmitoylates Hh N-terminal fragment (Gallus gallus)


name: SYVN1 ubiquitinates Hh C-terminal fragments (Gallus gallus)


name: Hedgehog ligand biogenesis (Drosophila melanogaster)


name: SYVN1 ubiquitinates Hh C-terminal fragments (Drosophila melanogaster)


name: HHAT palmitoylates Hh N-terminal fragment (Drosophila melanogaster)


name: Hh C-terminal fragments are degraded by the proteasome (Drosophila melanogaster)


name: Autoproteolytic cleavage of Hh precursors (Drosophila melanogaster)


name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Drosophila melanogaster)


name: Glycosylation of Hh (Drosophila melanogaster)


name: C-terminal Hh fragments are bound by lectins (Drosophila melanogaster)


name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Drosophila melanogaster)


name: P4HB forms mixed disulphides with Hh precursors (Drosophila melanogaster)


name: Hh-Np traffics to the plasma membrane (Drosophila melanogaster)


name: Hedgehog ligand biogenesis (Caenorhabditis elegans)


name: SYVN1 ubiquitinates Hh C-terminal fragments (Caenorhabditis elegans)


name: Hedgehog ligand biogenesis (Dictyostelium discoideum)


name: SYVN1 ubiquitinates Hh C-terminal fragments (Dictyostelium discoideum)


name: Hedgehog ligand biogenesis (Schizosaccharomyces pombe)


name: SYVN1 ubiquitinates Hh C-terminal fragments (Schizosaccharomyces pombe)


name: HHAT G278V doesn't palmitoylate Hh-Np (Homo sapiens)


name: HHAT G287V doesn't palmitoylate Hh-Np (Homo sapiens)


name: TGFBR2 MSI Frameshift Mutants in Cancer (Homo sapiens)


name: Dimeric TGFB1 does not bind TGFBR2 MSI frameshift mutants (Homo sapiens)


name: TGFBR2 Kinase Domain Mutants in Cancer (Homo sapiens)


name: TGFBR2 KD mutants do not phosphorylate TGFBR1 (Homo sapiens)


name: TGFBR1 LBD Mutants in Cancer (Homo sapiens)


name: TGFBR2 does not recruit TGFBR1 LBD Mutants (Homo sapiens)


name: TGFBR1 KD Mutants in Cancer (Homo sapiens)


name: An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants (Homo sapiens)


name: SMAD4 MH2 Domain Mutants in Cancer (Homo sapiens)


name: SMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3 (Homo sapiens)


name: SMAD2/3 Phosphorylation Motif Mutants in Cancer (Homo sapiens)


name: Activated TGFBR1 cannot phosphorylate SMAD2 and SMAD3 Phosphorylation Motif Mutants (Homo sapiens)


name: SMAD2/3 MH2 Domain Mutants in Cancer (Homo sapiens)


name: Phosphorylated SMAD2/3 MH2 Domain Mutants do not bind SMAD4 (Homo sapiens)


name: Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants (Homo sapiens)


name: PI3-kinase binds to mutant PDGFR receptor (Homo sapiens)


name: Autophosphorylation of PDGFR mutant dimers (Homo sapiens)


name: Ligand-independent dimerization of PDGFR mutants (Homo sapiens)


name: SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors (Homo sapiens)


name: GRB2:SOS1 complex binds to mutant PDGFR receptor (Homo sapiens)


name: STAT binds to the mutant PDGFRA receptor (Homo sapiens)


name: PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)


name: Signaling by cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)


name: Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)


name: Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)


name: Signaling by PDGFRA extracellular domain mutants (Homo sapiens)


name: Autophosphorylation of PDGFRA extracellular domain dimers (Homo sapiens)


name: GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers (Homo sapiens)


name: Ligand-independent dimerization of PDGFRA extracellular domain mutants (Homo sapiens)


name: STAT binds to p-11Y PDGFRA extracellular domain dimers  (Homo sapiens)


name: PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)


name: PI3-kinase binds to PDGFRA extracellular domain dimers (Homo sapiens)


name: SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers (Homo sapiens)


name: Signaling by membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)


name: Ligand-independent dimerization of membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)


name: Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)


name: Regorafenib-resistant PDGFR mutants (Homo sapiens)


name: Regorafenib-resistant PDGFR mutants don't bind regorafenib (Homo sapiens)


name: Sunitinib-resistant PDGFR mutants (Homo sapiens)


name: D842V PDGFRA doesn't bind sunitinib (Homo sapiens)


name: Sorafenib-resistant PDGFR mutants (Homo sapiens)


name: Sorafenib-resistant PDGFR mutants don't bind sorefenib (Homo sapiens)


name: Imatinib-resistant PDGFR mutants (Homo sapiens)


name: Imatinib-resistant PDGFR mutants don't bind imatinib (Homo sapiens)


name: PDGFR mutants bind type II TKIs (Homo sapiens)


name: PDGFR mutants bind type I TKIs (Homo sapiens)


name: Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (Homo sapiens)


name: NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1 (Homo sapiens)


name: NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1 (Homo sapiens)


name: NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 (Homo sapiens)


name: NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2 (Homo sapiens)


name: NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4 (Homo sapiens)


name: Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)


name: NICD1 PEST domain mutants translocate from cytosol to nucleus (Homo sapiens)


name: NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants (Homo sapiens)


name: NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC (Homo sapiens)


name: NOTCH1 PEST domain mutants bind DLL1  (Homo sapiens)


name: NOTCH1 PEST domain mutants stimulate MYC transcription (Homo sapiens)


name: NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)


name: NOTCH1 PEST domain mutants stimulate HEY transcription (Homo sapiens)


name: NOTCH1 PEST domain mutants bind HES5 promoter (Homo sapiens)


name: NOTCH1 PEST domain mutants stimulate HES1 transcription (Homo sapiens)


name: NOTCH1 PEST domain mutants bind promoters of HEY genes (Homo sapiens)


name: ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants (Homo sapiens)


name: NOTCH1 PEST domain mutants bind JAG1 (Homo sapiens)


name: NOTCH1 PEST domain mutants bind HES1 promoter (Homo sapiens)


name: NOTCH1 PEST domain mutants bind JAG2 (Homo sapiens)


name: CDK8 phosphorylates NICD1 PEST domain mutants  (Homo sapiens)


name: NOTCH1 PEST domain mutants bind MYC promoter (Homo sapiens)


name: NOTCH1 PEST domain mutants stimulate HES5 transcription (Homo sapiens)


name: p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)


name: NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML (Homo sapiens)


name: Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants (Homo sapiens)


name: NOTCH1 PEST domain mutants bind DLL4 (Homo sapiens)


name: Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling (Homo sapiens)


name: FBXW7 WD mutants do not bind NICD1 (Homo sapiens)


name: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)


name: NOTCH1 HD+PEST domain mutants bind JAG2 (Homo sapiens)


name: NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding (Homo sapiens)


name: Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants (Homo sapiens)


name: NOTCH1 HD+PEST domain mutants bind JAG1 (Homo sapiens)


name: NOTCH1 HD+PEST domain mutants bind DLL4 (Homo sapiens)


name: NOTCH1 HD+PEST domain mutants bind DLL1 (Homo sapiens)


name: Constitutive Signaling by NOTCH1 HD Domain Mutants (Homo sapiens)


name: NOTCH1 HD domain mutants bind DLL1 (Homo sapiens)


name: NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding (Homo sapiens)


name: Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants (Homo sapiens)


name: NOTCH1 HD domain mutants bind JAG2 (Homo sapiens)


name: NOTCH1 HD domain mutants bind JAG1 (Homo sapiens)


name: NOTCH1 HD domain mutants bind DLL4 (Homo sapiens)


name: Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)


name: Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 (Homo sapiens)


name: Binding of SHC1 to p-6Y-EGFR mutants (Homo sapiens)


name: Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants (Homo sapiens)


name: Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)


name: SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)


name: Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants (Homo sapiens)


name: Binding of CBL to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)


name: Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants (Homo sapiens)


name: Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants (Homo sapiens)


name: Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors (Homo sapiens)


name: Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)


name: Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)


name: PLCG1 binds to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)


name: Spontaneous dimerization of ligand-responsive EGFR mutants (Homo sapiens)


name: Binding of EGF to ligand-responsive EGFR mutants (Homo sapiens)


name: Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL (Homo sapiens)


name: EGF-induced dimerization of ligand-responsive EGFR mutants (Homo sapiens)


name: SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)


name: Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)


name: Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)


name: HSP90 is inactivated by binding to benzaquinoid ansamycins (Homo sapiens)


name: Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex (Homo sapiens)


name: Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers (Homo sapiens)


name: Constitutive Signaling by EGFRvIII (Homo sapiens)


name: Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)


name: Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant (Homo sapiens)


name: Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII (Homo sapiens)


name: Trans-autophosphorylation of EGFRvIII mutant dimers (Homo sapiens)


name: SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) (Homo sapiens)


name: PLC-gamma 1 binds to p-EGFRvIII mutant (Homo sapiens)


name: Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant (Homo sapiens)


name: EGFRvIII does not bind CBL (Homo sapiens)


name: Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII (Homo sapiens)


name: Binding of GRB2:GAB1 complex to p-EGFRvIII mutant (Homo sapiens)


name: Phosphorylation of SHC1 by p-5Y-EGFRvIII (Homo sapiens)


name: Ligand-independent dimerization of EGFRvIII mutant (Homo sapiens)


name: Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex (Homo sapiens)


name: Binding of SHC1 to p-5Y-EGFRvIII (Homo sapiens)


name: EGFRvIII cancer variant does not bind EGF ligand (Homo sapiens)


name: EGFRvIII mutant binds chaperone proteins HSP90 and CDC37. (Homo sapiens)


name: SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (Homo sapiens)


name: Inhibition of Signaling by Overexpressed EGFR (Homo sapiens)


name: Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers (Homo sapiens)


name: Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody (Homo sapiens)


name: ALK mutants bind type I TKIs (Homo sapiens)


name: STAT3 is phosphorylated downstream of active ALK (Homo sapiens)


name: MYC/MYCN bind the ALK gene (Homo sapiens)


name: p-Y705,S727-STAT3 dimerizes (Homo sapiens)


name: p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Homo sapiens)


name: Active ALK phosphorylates FRS2 (Homo sapiens)


name: PTPN6 dephosphorylates JAK3 (Homo sapiens)


name: ALK-stimulated MYCN gene expression (Homo sapiens)


name: Active ALK phosphorylates SHC1 (Homo sapiens)


name: Active ALK phosphorylates IRS1 (Homo sapiens)


name: Active ALK phosphorylates PLCG1 (Homo sapiens)


name: Liganded-ALK dimer binds type I ALK-binding TKIs (Homo sapiens)


name: Active ALK phosphorylates JAK3 (Homo sapiens)


name: PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)


name: Active ALK dimer binds IRS1 (Homo sapiens)


name: Active ALK phosphorylates SRC (Homo sapiens)


name: MDK and PTN in ALK signaling (Homo sapiens)


name: (PTN,MDK):PTPRZ oligomerizes (Homo sapiens)


name: ALK:MDK dimerization (Homo sapiens)


name: ALK binds ligand pleiotrophin (PTN) (Homo sapiens)


name: PTN and MDK bind to PTPRZ (Homo sapiens)


name: PTPRZ dephosphorylates ligand-bound ALK dimers (Homo sapiens)


name: ALK:PTN dimerization (Homo sapiens)


name: ALK binds ligand midkine (MDK) (Homo sapiens)


name: MDK and PTN in ALK signaling (Mus musculus)


name: PTPRZ dephosphorylates ligand-bound ALK dimers (Mus musculus)


name: (PTN,MDK):PTPRZ oligomerizes (Mus musculus)


name: ALK binds ligand midkine (MDK) (Mus musculus)


name: PTN and MDK bind to PTPRZ (Mus musculus)


name: ALK binds ligand pleiotrophin (PTN) (Mus musculus)


name: MDK and PTN in ALK signaling (Rattus norvegicus)


name: (PTN,MDK):PTPRZ oligomerizes (Rattus norvegicus)


name: PTPRZ dephosphorylates ligand-bound ALK dimers (Rattus norvegicus)


name: PTN and MDK bind to PTPRZ (Rattus norvegicus)


name: ALK binds ligand pleiotrophin (PTN) (Rattus norvegicus)


name: ALK binds ligand midkine (MDK) (Rattus norvegicus)


name: MDK and PTN in ALK signaling (Canis familiaris)


name: PTPRZ dephosphorylates ligand-bound ALK dimers (Canis familiaris)


name: ALK binds ligand midkine (MDK) (Canis familiaris)


name: ALK binds ligand pleiotrophin (PTN) (Canis familiaris)


name: (PTN,MDK):PTPRZ oligomerizes (Canis familiaris)


name: PTN and MDK bind to PTPRZ (Canis familiaris)


name: MDK and PTN in ALK signaling (Bos taurus)


name: ALK binds ligand midkine (MDK) (Bos taurus)


name: (PTN,MDK):PTPRZ oligomerizes (Bos taurus)


name: PTPRZ dephosphorylates ligand-bound ALK dimers (Bos taurus)


name: ALK binds ligand pleiotrophin (PTN) (Bos taurus)


name: MDK and PTN in ALK signaling (Sus scrofa)


name: ALK binds ligand midkine (MDK) (Sus scrofa)


name: ALK binds ligand pleiotrophin (PTN) (Sus scrofa)


name: (PTN,MDK):PTPRZ oligomerizes (Sus scrofa)


name: PTPRZ dephosphorylates ligand-bound ALK dimers (Sus scrofa)


name: MDK and PTN in ALK signaling (Danio rerio)


name: ALK binds ligand midkine (MDK) (Danio rerio)


name: ALK binds ligand pleiotrophin (PTN) (Danio rerio)


name: MDK and PTN in ALK signaling (Gallus gallus)


name: PTPRZ dephosphorylates ligand-bound ALK dimers (Gallus gallus)


name: ALK binds ligand pleiotrophin (PTN) (Gallus gallus)


name: (PTN,MDK):PTPRZ oligomerizes (Gallus gallus)


name: ALK binds ligand midkine (MDK) (Gallus gallus)


name: PTN and MDK bind to PTPRZ (Gallus gallus)


name: STAT3 nuclear events downstream of ALK signaling (Homo sapiens)


name: p-Y705,S727 STAT3 is acetylated (Homo sapiens)


name: CD274 gene expression downstream of ALK signaling (Homo sapiens)


name: p-Y705, S727 STAT3 dimer binds HIF1A gene (Homo sapiens)


name: AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter (Homo sapiens)


name: HDACs deacetylate p-STAT3 dimers (Homo sapiens)


name: PRDM1 gene expression downstream of ALK signaling (Homo sapiens)


name: p-Y705, S727 STAT3 dimer binds CD274 gene (Homo sapiens)


name: ALK- and STAT3-dependent HIF1A gene expression (Homo sapiens)


name: AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene (Homo sapiens)


name: AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter (Homo sapiens)


name: IL2RG gene expression downstream of ALK signaling (Homo sapiens)


name: STAT3 nuclear events downstream of ALK signaling (Mus musculus)


name: HDACs deacetylate p-STAT3 dimers (Mus musculus)


name: p-Y705,S727 STAT3 is acetylated (Mus musculus)


name: STAT3 nuclear events downstream of ALK signaling (Rattus norvegicus)


name: HDACs deacetylate p-STAT3 dimers (Rattus norvegicus)


name: p-Y705,S727 STAT3 is acetylated (Rattus norvegicus)


name: STAT3 nuclear events downstream of ALK signaling (Canis familiaris)


name: p-Y705,S727 STAT3 is acetylated (Canis familiaris)


name: HDACs deacetylate p-STAT3 dimers (Canis familiaris)


name: STAT3 nuclear events downstream of ALK signaling (Bos taurus)


name: p-Y705,S727 STAT3 is acetylated (Bos taurus)


name: HDACs deacetylate p-STAT3 dimers (Bos taurus)


name: STAT3 nuclear events downstream of ALK signaling (Sus scrofa)


name: p-Y705,S727 STAT3 is acetylated (Sus scrofa)


name: HDACs deacetylate p-STAT3 dimers (Sus scrofa)


name: STAT3 nuclear events downstream of ALK signaling (Xenopus tropicalis)


name: HDACs deacetylate p-STAT3 dimers (Xenopus tropicalis)


name: p-Y705,S727 STAT3 is acetylated (Xenopus tropicalis)


name: STAT3 nuclear events downstream of ALK signaling (Gallus gallus)


name: p-Y705,S727 STAT3 is acetylated (Gallus gallus)


name: HDACs deacetylate p-STAT3 dimers (Gallus gallus)


name: STAT3 nuclear events downstream of ALK signaling (Drosophila melanogaster)


name: HDACs deacetylate p-STAT3 dimers (Drosophila melanogaster)


name: p-Y705,S727 STAT3 is acetylated (Drosophila melanogaster)


name: STAT3 nuclear events downstream of ALK signaling (Caenorhabditis elegans)


name: p-Y705,S727 STAT3 is acetylated (Caenorhabditis elegans)


name: HDACs deacetylate p-STAT3 dimers (Caenorhabditis elegans)


name: STAT3 nuclear events downstream of ALK signaling (Dictyostelium discoideum)


name: HDACs deacetylate p-STAT3 dimers (Dictyostelium discoideum)


name: IL10 positively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)


name: p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)


name: JAK1,TYK2 phosphorylate JAK1,TYK2 (Homo sapiens)


name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)


name: IL10 positively regulates extracellular inflammatory mediators (Homo sapiens)


name: IL10 negatively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)


name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Homo sapiens)


name: IL10 dimer binds IL10RA:JAK1 (Homo sapiens)


name: IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)


name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Homo sapiens)


name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Homo sapiens)


name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Homo sapiens)


name: JAK1,TYK2 phosphorylate JAK1,TYK2 (Mus musculus)


name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Mus musculus)


name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Mus musculus)


name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Mus musculus)


name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Mus musculus)


name: p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Mus musculus)


name: IL10 dimer binds IL10RA:JAK1 (Mus musculus)


name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Mus musculus)


name: Interleukin-10 signaling (Rattus norvegicus)


name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Rattus norvegicus)


name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Rattus norvegicus)


name: IL10 dimer binds IL10RA:JAK1 (Rattus norvegicus)


name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Rattus norvegicus)


name: p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Rattus norvegicus)


name: p-Y705-STAT3 dimerizes (Rattus norvegicus)


name: JAK1,TYK2 phosphorylate JAK1,TYK2 (Rattus norvegicus)


name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Rattus norvegicus)


name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Rattus norvegicus)


name: Interleukin-10 signaling (Canis familiaris)


name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Canis familiaris)


name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Canis familiaris)


name: IL10 dimer binds IL10RA:JAK1 (Canis familiaris)


name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Canis familiaris)


name: p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Canis familiaris)


name: JAK1,TYK2 phosphorylate JAK1,TYK2 (Canis familiaris)


name: p-Y705-STAT3 dimerizes (Canis familiaris)


name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Canis familiaris)


name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Canis familiaris)


name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Bos taurus)


name: p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Bos taurus)


name: JAK1,TYK2 phosphorylate JAK1,TYK2 (Bos taurus)


name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Bos taurus)


name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Bos taurus)


name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Bos taurus)


name: IL10 dimer binds IL10RA:JAK1 (Bos taurus)


name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Bos taurus)


name: p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Sus scrofa)


name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Sus scrofa)


name: IL10 dimer binds IL10RA:JAK1 (Sus scrofa)


name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Sus scrofa)


name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Sus scrofa)


name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Sus scrofa)


name: JAK1,TYK2 phosphorylate JAK1,TYK2 (Sus scrofa)


name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Sus scrofa)


name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Danio rerio)


name: JAK1,TYK2 phosphorylate JAK1,TYK2 (Danio rerio)


name: IL10 dimer binds IL10RA:JAK1 (Danio rerio)


name: Interleukin-10 signaling (Xenopus tropicalis)


name: p-Y705-STAT3 dimerizes (Xenopus tropicalis)


name: p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Xenopus tropicalis)


name: IL10 dimer binds IL10RA:JAK1 (Xenopus tropicalis)


name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Xenopus tropicalis)


name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Xenopus tropicalis)


name: JAK1,TYK2 phosphorylate JAK1,TYK2 (Xenopus tropicalis)


name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Xenopus tropicalis)


name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Xenopus tropicalis)


name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Xenopus tropicalis)


name: Interleukin-10 signaling (Gallus gallus)


name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Gallus gallus)


name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Gallus gallus)


name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Gallus gallus)


name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Gallus gallus)


name: JAK1,TYK2 phosphorylate JAK1,TYK2 (Gallus gallus)


name: p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Gallus gallus)


name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Gallus gallus)


name: IL10 dimer binds IL10RA:JAK1 (Gallus gallus)


name: Interleukin-10 signaling (Drosophila melanogaster)


name: p-Y705-STAT3 dimerizes (Drosophila melanogaster)


name: p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Drosophila melanogaster)


name: Interleukin-10 signaling (Caenorhabditis elegans)


name: p-Y705-STAT3 dimerizes (Caenorhabditis elegans)


name: p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Caenorhabditis elegans)


name: Interleukin-10 signaling (Dictyostelium discoideum)


name: p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Dictyostelium discoideum)


name: p-Y705-STAT3 dimerizes (Dictyostelium discoideum)


name: STAT3 is phosphorylated downstream of active ALK (Mus musculus)


name: PTPN6 dephosphorylates JAK3 (Mus musculus)


name: PI3K synthesizes PIP3 downstream of ALK (Mus musculus)


name: Active ALK phosphorylates IRS1 (Mus musculus)


name: Active ALK phosphorylates JAK3 (Mus musculus)


name: Active ALK phosphorylates SHC1 (Mus musculus)


name: p-Y705,S727-STAT3 dimerizes (Mus musculus)


name: Active ALK phosphorylates PLCG1 (Mus musculus)


name: p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Mus musculus)


name: Active ALK dimer binds IRS1 (Mus musculus)


name: Liganded-ALK dimer binds type I ALK-binding TKIs (Mus musculus)


name: p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Rattus norvegicus)


name: Active ALK binds SHC1 (Rattus norvegicus)


name: ALK autophosphorylation  (Rattus norvegicus)


name: Liganded-ALK dimer binds type I ALK-binding TKIs (Rattus norvegicus)


name: Active ALK binds PLCG1 (Rattus norvegicus)


name: Active ALK binds JAK3 (Rattus norvegicus)


name: PTPN6 dephosphorylates JAK3 (Rattus norvegicus)


name: Active ALK phosphorylates IRS1 (Rattus norvegicus)


name: STAT3 is phosphorylated downstream of active ALK (Rattus norvegicus)


name: Active ALK dimer binds IRS1 (Rattus norvegicus)


name: Active ALK phosphorylates JAK3 (Rattus norvegicus)


name: Active ALK recruits PI3K (Rattus norvegicus)


name: PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)


name: Active ALK phosphorylates SHC1 (Rattus norvegicus)


name: p-Y705,S727-STAT3 dimerizes (Rattus norvegicus)


name: ALK binds ALKAL ligand (Rattus norvegicus)


name: Active ALK phosphorylates PLCG1 (Rattus norvegicus)


name: Active ALK binds JAK3 (Canis familiaris)


name: Active ALK recruits PI3K (Canis familiaris)


name: Liganded-ALK dimer binds type I ALK-binding TKIs (Canis familiaris)


name: Active ALK binds PLCG1 (Canis familiaris)


name: Active ALK binds SHC1 (Canis familiaris)


name: Active ALK phosphorylates JAK3 (Canis familiaris)


name: Active ALK dimer binds IRS1 (Canis familiaris)


name: STAT3 is phosphorylated downstream of active ALK (Canis familiaris)


name: PTPN6 dephosphorylates JAK3 (Canis familiaris)


name: Active ALK phosphorylates IRS1 (Canis familiaris)


name: p-Y705,S727-STAT3 dimerizes (Canis familiaris)


name: ALK autophosphorylation  (Canis familiaris)


name: Active ALK phosphorylates PLCG1 (Canis familiaris)


name: Active ALK phosphorylates SHC1 (Canis familiaris)


name: PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)


name: p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Canis familiaris)


name: ALK binds ALKAL ligand (Canis familiaris)


name: Active ALK dimer binds IRS1 (Bos taurus)


name: PI3K synthesizes PIP3 downstream of ALK (Bos taurus)


name: Active ALK phosphorylates IRS1 (Bos taurus)


name: Active ALK phosphorylates PLCG1 (Bos taurus)


name: Active ALK phosphorylates JAK3 (Bos taurus)


name: PTPN6 dephosphorylates JAK3 (Bos taurus)


name: STAT3 is phosphorylated downstream of active ALK (Bos taurus)


name: Active ALK phosphorylates SHC1 (Bos taurus)


name: p-Y705,S727-STAT3 dimerizes (Bos taurus)


name: p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Bos taurus)


name: Liganded-ALK dimer binds type I ALK-binding TKIs (Bos taurus)


name: Active ALK phosphorylates PLCG1 (Sus scrofa)


name: Active ALK phosphorylates JAK3 (Sus scrofa)


name: PTPN6 dephosphorylates JAK3 (Sus scrofa)


name: STAT3 is phosphorylated downstream of active ALK (Sus scrofa)


name: Active ALK phosphorylates SHC1 (Sus scrofa)


name: PI3K synthesizes PIP3 downstream of ALK (Sus scrofa)


name: p-Y705,S727-STAT3 dimerizes (Sus scrofa)


name: Liganded-ALK dimer binds type I ALK-binding TKIs (Sus scrofa)


name: p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Sus scrofa)


name: Active ALK dimer binds IRS1 (Sus scrofa)


name: Active ALK phosphorylates IRS1 (Sus scrofa)


name: Liganded-ALK dimer binds type I ALK-binding TKIs (Danio rerio)


name: PI3K synthesizes PIP3 downstream of ALK (Danio rerio)


name: Active ALK phosphorylates PLCG1 (Danio rerio)


name: p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Xenopus tropicalis)


name: PI3K synthesizes PIP3 downstream of ALK (Xenopus tropicalis)


name: p-Y705,S727-STAT3 dimerizes (Xenopus tropicalis)


name: ALK autophosphorylation  (Gallus gallus)


name: p-Y705,S727-STAT3 dimerizes (Gallus gallus)


name: STAT3 is phosphorylated downstream of active ALK (Gallus gallus)


name: Liganded-ALK dimer binds type I ALK-binding TKIs (Gallus gallus)


name: Active ALK phosphorylates SHC1 (Gallus gallus)


name: Active ALK phosphorylates PLCG1 (Gallus gallus)


name: Active ALK recruits PI3K (Gallus gallus)


name: PI3K synthesizes PIP3 downstream of ALK (Gallus gallus)


name: p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Gallus gallus)


name: Active ALK phosphorylates IRS1 (Gallus gallus)


name: Active ALK dimer binds IRS1 (Gallus gallus)


name: Signaling by ALK (Drosophila melanogaster)


name: p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Drosophila melanogaster)


name: p-Y705,S727-STAT3 dimerizes (Drosophila melanogaster)


name: PI3K synthesizes PIP3 downstream of ALK (Drosophila melanogaster)


name: Signaling by ALK (Caenorhabditis elegans)


name: PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)


name: p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Caenorhabditis elegans)


name: p-Y705,S727-STAT3 dimerizes (Caenorhabditis elegans)


name: Signaling by ALK (Dictyostelium discoideum)


name: p-Y705,S727-STAT3 dimerizes (Dictyostelium discoideum)


name: p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Dictyostelium discoideum)


name: alectinib-resistant ALK mutants (Homo sapiens)


name: alectinib resistant ALK mutants don't bind alectinib (Homo sapiens)


name: NVP-TAE684-resistant ALK mutants (Homo sapiens)


name: NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 (Homo sapiens)


name: brigatinib-resistant ALK mutants (Homo sapiens)


name: brigatinib-resistant ALK mutants don't bind brigatinib (Homo sapiens)


name: ASP-3026-resistant ALK mutants (Homo sapiens)


name: ASP-3026- resistant ALK mutants don't bind ASP-3026 (Homo sapiens)


name: lorlatinib-resistant ALK mutants (Homo sapiens)


name: lorlatinib-resistant ALK mutants don't bind lorlatinib (Homo sapiens)


name: crizotinib-resistant ALK mutants (Homo sapiens)


name: crizotinib-resistant ALK mutants don't bind crizotinib (Homo sapiens)


name: ceritinib-resistant ALK mutants (Homo sapiens)


name: ceritinib-resistant ALK mutants don't bind ceritinib (Homo sapiens)


name: Signaling by ALK fusions and activated point mutants (Homo sapiens)


name: PI3K synthesizes PIP3 downstream of ALK mutants (Homo sapiens)


name: Autophosphorylation of ALK fusions (Homo sapiens)


name: ALK mutants phosphorylate STAT3 (Homo sapiens)


name: ALK fusions phosphorylate PLCG1 (Homo sapiens)


name: ALK fusions phosphorylate FRS (Homo sapiens)


name: ALK fusions phosphorylate IRS1 (Homo sapiens)


name: Ligand-independent dimerization of ALK fusions (Homo sapiens)


name: NPM1-ALK- and PI3K-dependent MDM2 phosphorylation (Homo sapiens)


name: Ligand-independent dimerization of point mutants of ALK (Homo sapiens)


name: ALK fusion proteins bind IRS (Homo sapiens)


name: NPM1-ALK- and JUN-dependent CDKN1A gene repression (Homo sapiens)


name: Autophosphorylation of point mutants of ALK (Homo sapiens)


name: NPM1-ALK- and JNK-dependent JUN phosphorylation (Homo sapiens)


name: TYK2-dependent STAT1 and STAT3 phosphorylation (Homo sapiens)


name: NPM1-ALK-dependent MAPK8,9 phosphorylation (Homo sapiens)


name: ALK fusion proteins bind PLCG1 (Homo sapiens)


name: p-T,Y MAPK8,9 translocate to the nucleus (Homo sapiens)


name: JNK-dependent inhibition of TP53 ubiquitination (Homo sapiens)


name: ALK mutants:p-3Y SHC binds GRB2 (Homo sapiens)


name: pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants (Homo sapiens)


name: MYH9- and RNF213-ALK fusions are phosphorylated (Homo sapiens)


name: ALK mutants phosphorylate SHC1 (Homo sapiens)


name: NPM1-ALK-dependent TYK2 phosphorylation (Homo sapiens)


name: NPM1-ALK- and TYK2-dependent MCL1 gene expression (Homo sapiens)


name: Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)


name: NPM1-ALK and FOXM1-dependent CCNB1 gene expression (Homo sapiens)


name: NPM1-ALK binds NPM1 and FOXM1 (Homo sapiens)


name: NPM1-ALK translocates to the nucleus (Homo sapiens)


name: JUNB- and NPM1-ALK-mediated GZMB gene expression (Homo sapiens)


name: NPM1-ALK-dependent JUNB gene transcription (Homo sapiens)


name: NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1 (Homo sapiens)


name: NPM1-ALK-dependent BCL2A1 gene expression (Homo sapiens)


name: STAT3-dependent MIR-21 gene expression (Homo sapiens)


name: DNMT1-dependent PTPN6 gene silencing (Homo sapiens)


name: STAT3-dependent DNMT1 gene expression (Homo sapiens)


name: JUNB dimer binds GZMB promoter (Homo sapiens)


name: ALK-, STAT3- and MECP2-dependent STAT5A gene repression (Homo sapiens)


name: miR-21 RISC binds DNMT1 mRNA (Homo sapiens)


name: Translation of DNMT1 mRNA is repressed by miR-21 (Homo sapiens)


name: AcK685 pY705,S727 STAT3 binds the MIR21 gene (Homo sapiens)


name: NPM1-ALK-dependent repression of pRB phosphorylation (Homo sapiens)


name: p-Y705,S727 STAT3 dimer binds NOTCH gene (Homo sapiens)


name: NPM1-ALK- and p-STAT3-dependent NOTCH gene expression (Homo sapiens)


name: MECP2 binds the STAT5A gene (Homo sapiens)


name: STAT3, DNMT1 and HDAC1 bind PTPN6 gene (Homo sapiens)


name: Crizotinib-driven IL10RA gene expression in NPM1-ALK (Homo sapiens)


name: STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing (Homo sapiens)


name: NPM1-ALK-stimulated PRF1 gene expression (Homo sapiens)


name: AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter (Homo sapiens)


name: MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner (Homo sapiens)


name: NPM1-ALK- and STAT3-dependent TWIST gene expression (Homo sapiens)


name: p-Y705, S727 STAT3 dimer binds ICOS promoter (Homo sapiens)


name: NPM1-ALK-dependent JUNB translation (Homo sapiens)


name: NPM1-ALK- and STAT3-dependent ICOS gene expression (Homo sapiens)


name: pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK (Homo sapiens)


name: NPM1-ALK-dependent CEBPB gene expression (Homo sapiens)


name: NPM1-ALK- and p-STAT3-dependent IRF4 gene expression (Homo sapiens)


name: Defective HLCS causes multiple carboxylase deficiency (Homo sapiens)


name: Defective HLCS does not biotinylate 6x(PCCA:PCCB) (Homo sapiens)


name: Defective HLCS does not biotinylate PC:Mn2+ (Homo sapiens)


name: Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2 (Homo sapiens)


name: Defective HLCS does not biotinylate ACACA:Mn2+ (Homo sapiens)


name: Vitamin B1 (thiamin) metabolism (Homo sapiens)


name: TDPK phosphorylates ThDP to ThTP (Homo sapiens)


name: 2xTPK1:Mg2+ phosphorylates THMN (Homo sapiens)


name: thiamine pyrophosphate transmembrane transporter activity

description: Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other.


name: SLC19A2/3 transport extracellular THMN to cytosol (Homo sapiens)


name: THTPA:Mg2+ hydrolyzes ThTP to TDP (Homo sapiens)


name: Vitamin B1 (thiamin) metabolism (Mus musculus)


name: 2xTPK1:Mg2+ phosphorylates THMN (Mus musculus)


name: THTPA:Mg2+ hydrolyzes ThTP to TDP (Mus musculus)


name: SLC19A2/3 transport extracellular THMN to cytosol (Mus musculus)


name: SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Mus musculus)


name: Vitamin B1 (thiamin) metabolism (Rattus norvegicus)


name: 2xTPK1:Mg2+ phosphorylates THMN (Rattus norvegicus)


name: SLC19A2/3 transport extracellular THMN to cytosol (Rattus norvegicus)


name: THTPA:Mg2+ hydrolyzes ThTP to TDP (Rattus norvegicus)


name: Vitamin B1 (thiamin) metabolism (Canis familiaris)


name: THTPA:Mg2+ hydrolyzes ThTP to TDP (Canis familiaris)


name: SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Canis familiaris)


name: SLC19A2/3 transport extracellular THMN to cytosol (Canis familiaris)


name: 2xTPK1:Mg2+ phosphorylates THMN (Canis familiaris)


name: Vitamin B1 (thiamin) metabolism (Bos taurus)


name: SLC19A2/3 transport extracellular THMN to cytosol (Bos taurus)


name: THTPA:Mg2+ hydrolyzes ThTP to TDP (Bos taurus)


name: SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Bos taurus)


name: 2xTPK1:Mg2+ phosphorylates THMN (Bos taurus)


name: Vitamin B1 (thiamin) metabolism (Sus scrofa)


name: THTPA:Mg2+ hydrolyzes ThTP to TDP (Sus scrofa)


name: SLC19A2/3 transport extracellular THMN to cytosol (Sus scrofa)


name: 2xTPK1:Mg2+ phosphorylates THMN (Sus scrofa)


name: SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Sus scrofa)


name: Vitamin B1 (thiamin) metabolism (Danio rerio)


name: SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Danio rerio)


name: 2xTPK1:Mg2+ phosphorylates THMN (Danio rerio)


name: Vitamin B1 (thiamin) metabolism (Xenopus tropicalis)


name: THTPA:Mg2+ hydrolyzes ThTP to TDP (Xenopus tropicalis)


name: SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Xenopus tropicalis)


name: SLC19A2/3 transport extracellular THMN to cytosol (Xenopus tropicalis)


name: 2xTPK1:Mg2+ phosphorylates THMN (Xenopus tropicalis)


name: Vitamin B1 (thiamin) metabolism (Drosophila melanogaster)


name: 2xTPK1:Mg2+ phosphorylates THMN (Drosophila melanogaster)


name: SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Drosophila melanogaster)


name: SLC19A2/3 transport extracellular THMN to cytosol (Drosophila melanogaster)


name: Vitamin B1 (thiamin) metabolism (Caenorhabditis elegans)


name: 2xTPK1:Mg2+ phosphorylates THMN (Caenorhabditis elegans)


name: SLC19A2/3 transport extracellular THMN to cytosol (Caenorhabditis elegans)


name: SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Caenorhabditis elegans)


name: Vitamin B1 (thiamin) metabolism (Dictyostelium discoideum)


name: SLC19A2/3 transport extracellular THMN to cytosol (Dictyostelium discoideum)


name: SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Dictyostelium discoideum)


name: 2xTPK1:Mg2+ phosphorylates THMN (Dictyostelium discoideum)


name: Vitamin B1 (thiamin) metabolism (Schizosaccharomyces pombe)


name: SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)


name: 2xTPK1:Mg2+ phosphorylates THMN (Schizosaccharomyces pombe)


name: Vitamin B1 (thiamin) metabolism (Saccharomyces cerevisiae)


name: SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)


name: 2xTPK1:Mg2+ phosphorylates THMN (Saccharomyces cerevisiae)


name: Vitamin B1 (thiamin) metabolism (Plasmodium falciparum)


name: 2xTPK1:Mg2+ phosphorylates THMN (Plasmodium falciparum)


name: Vitamin B6 activation to pyridoxal phosphate (Homo sapiens)


name: 2xPDKX:2xZn2+ phosphorylates PDX (Homo sapiens)


name: 2xPNPO:2xFMN oxidizes PXAP to PXLP (Homo sapiens)


name: AOX1 oxidises PXL to PDXate (Homo sapiens)


name: 2xPNPO:2xFMN oxidizes PDXP to PXLP (Homo sapiens)


name: 2xPDXK:2xZn2+ phosphorylates PXL (Homo sapiens)


name: 2xPDXK:2xZn2+ phosphorylates PXA (Homo sapiens)


name: Vitamin B6 activation to pyridoxal phosphate (Mus musculus)


name: 2xPDKX:2xZn2+ phosphorylates PDX (Mus musculus)


name: 2xPDXK:2xZn2+ phosphorylates PXL (Mus musculus)


name: 2xPNPO:2xFMN oxidizes PXAP to PXLP (Mus musculus)


name: AOX1 oxidises PXL to PDXate (Mus musculus)


name: 2xPNPO:2xFMN oxidizes PDXP to PXLP (Mus musculus)


name: 2xPDXK:2xZn2+ phosphorylates PXA (Mus musculus)


name: Vitamin B6 activation to pyridoxal phosphate (Rattus norvegicus)


name: AOX1 oxidises PXL to PDXate (Rattus norvegicus)


name: 2xPDXK:2xZn2+ phosphorylates PXL (Rattus norvegicus)


name: 2xPNPO:2xFMN oxidizes PDXP to PXLP (Rattus norvegicus)


name: 2xPDKX:2xZn2+ phosphorylates PDX (Rattus norvegicus)


name: 2xPNPO:2xFMN oxidizes PXAP to PXLP (Rattus norvegicus)


name: 2xPDXK:2xZn2+ phosphorylates PXA (Rattus norvegicus)


name: Vitamin B6 activation to pyridoxal phosphate (Canis familiaris)


name: 2xPNPO:2xFMN oxidizes PDXP to PXLP (Canis familiaris)


name: 2xPNPO:2xFMN oxidizes PXAP to PXLP (Canis familiaris)


name: 2xPDKX:2xZn2+ phosphorylates PDX (Canis familiaris)


name: 2xPDXK:2xZn2+ phosphorylates PXL (Canis familiaris)


name: 2xPDXK:2xZn2+ phosphorylates PXA (Canis familiaris)


name: Vitamin B6 activation to pyridoxal phosphate (Bos taurus)


name: AOX1 oxidises PXL to PDXate (Bos taurus)


name: 2xPDKX:2xZn2+ phosphorylates PDX (Bos taurus)


name: 2xPDXK:2xZn2+ phosphorylates PXA (Bos taurus)


name: 2xPDXK:2xZn2+ phosphorylates PXL (Bos taurus)


name: 2xPNPO:2xFMN oxidizes PXAP to PXLP (Bos taurus)


name: 2xPNPO:2xFMN oxidizes PDXP to PXLP (Bos taurus)


name: Vitamin B6 activation to pyridoxal phosphate (Sus scrofa)


name: 2xPDKX:2xZn2+ phosphorylates PDX (Sus scrofa)


name: 2xPDXK:2xZn2+ phosphorylates PXL (Sus scrofa)


name: AOX1 oxidises PXL to PDXate (Sus scrofa)


name: 2xPNPO:2xFMN oxidizes PXAP to PXLP (Sus scrofa)


name: 2xPNPO:2xFMN oxidizes PDXP to PXLP (Sus scrofa)


name: 2xPDXK:2xZn2+ phosphorylates PXA (Sus scrofa)


name: Vitamin B6 activation to pyridoxal phosphate (Danio rerio)


name: 2xPDKX:2xZn2+ phosphorylates PDX (Danio rerio)


name: 2xPDXK:2xZn2+ phosphorylates PXA (Danio rerio)


name: AOX1 oxidises PXL to PDXate (Danio rerio)


name: 2xPDXK:2xZn2+ phosphorylates PXL (Danio rerio)


name: Vitamin B6 activation to pyridoxal phosphate (Xenopus tropicalis)


name: 2xPDXK:2xZn2+ phosphorylates PXL (Xenopus tropicalis)


name: 2xPDKX:2xZn2+ phosphorylates PDX (Xenopus tropicalis)


name: 2xPDXK:2xZn2+ phosphorylates PXA (Xenopus tropicalis)


name: 2xPNPO:2xFMN oxidizes PDXP to PXLP (Xenopus tropicalis)


name: AOX1 oxidises PXL to PDXate (Xenopus tropicalis)


name: 2xPNPO:2xFMN oxidizes PXAP to PXLP (Xenopus tropicalis)


name: Vitamin B6 activation to pyridoxal phosphate (Drosophila melanogaster)


name: 2xPDKX:2xZn2+ phosphorylates PDX (Drosophila melanogaster)


name: 2xPDXK:2xZn2+ phosphorylates PXL (Drosophila melanogaster)


name: 2xPNPO:2xFMN oxidizes PDXP to PXLP (Drosophila melanogaster)


name: 2xPNPO:2xFMN oxidizes PXAP to PXLP (Drosophila melanogaster)


name: 2xPDXK:2xZn2+ phosphorylates PXA (Drosophila melanogaster)


name: AOX1 oxidises PXL to PDXate (Drosophila melanogaster)


name: Vitamin B6 activation to pyridoxal phosphate (Caenorhabditis elegans)


name: 2xPNPO:2xFMN oxidizes PDXP to PXLP (Caenorhabditis elegans)


name: AOX1 oxidises PXL to PDXate (Caenorhabditis elegans)


name: 2xPDKX:2xZn2+ phosphorylates PDX (Caenorhabditis elegans)


name: 2xPNPO:2xFMN oxidizes PXAP to PXLP (Caenorhabditis elegans)


name: 2xPDXK:2xZn2+ phosphorylates PXA (Caenorhabditis elegans)


name: 2xPDXK:2xZn2+ phosphorylates PXL (Caenorhabditis elegans)


name: Vitamin B6 activation to pyridoxal phosphate (Dictyostelium discoideum)


name: AOX1 oxidises PXL to PDXate (Dictyostelium discoideum)


name: 2xPNPO:2xFMN oxidizes PXAP to PXLP (Dictyostelium discoideum)


name: 2xPDXK:2xZn2+ phosphorylates PXA (Dictyostelium discoideum)


name: 2xPDKX:2xZn2+ phosphorylates PDX (Dictyostelium discoideum)


name: 2xPDXK:2xZn2+ phosphorylates PXL (Dictyostelium discoideum)


name: 2xPNPO:2xFMN oxidizes PDXP to PXLP (Dictyostelium discoideum)


name: Vitamin B6 activation to pyridoxal phosphate (Schizosaccharomyces pombe)


name: 2xPDKX:2xZn2+ phosphorylates PDX (Schizosaccharomyces pombe)


name: 2xPDXK:2xZn2+ phosphorylates PXL (Schizosaccharomyces pombe)


name: 2xPNPO:2xFMN oxidizes PDXP to PXLP (Schizosaccharomyces pombe)


name: 2xPNPO:2xFMN oxidizes PXAP to PXLP (Schizosaccharomyces pombe)


name: 2xPDXK:2xZn2+ phosphorylates PXA (Schizosaccharomyces pombe)


name: Vitamin B6 activation to pyridoxal phosphate (Saccharomyces cerevisiae)


name: 2xPNPO:2xFMN oxidizes PDXP to PXLP (Saccharomyces cerevisiae)


name: 2xPNPO:2xFMN oxidizes PXAP to PXLP (Saccharomyces cerevisiae)


name: 2xPDXK:2xZn2+ phosphorylates PXA (Saccharomyces cerevisiae)


name: 2xPDKX:2xZn2+ phosphorylates PDX (Saccharomyces cerevisiae)


name: 2xPDXK:2xZn2+ phosphorylates PXL (Saccharomyces cerevisiae)


name: Vitamin B6 activation to pyridoxal phosphate (Plasmodium falciparum)


name: 2xPDXK:2xZn2+ phosphorylates PXA (Plasmodium falciparum)


name: 2xPDKX:2xZn2+ phosphorylates PDX (Plasmodium falciparum)


name: 2xPDXK:2xZn2+ phosphorylates PXL (Plasmodium falciparum)


name: Molybdenum cofactor biosynthesis (Homo sapiens)


name: Transfer of sulfur from MOCS3-S-S onto MOCS2A (Homo sapiens)


name: Sulfhydrylation and ring cleavage of precursor Z (Homo sapiens)


name: Exchange of oxygen with sulfur in MoCo (Homo sapiens)


name: Molybdenum ion transfer onto molybdopterin (Homo sapiens)


name: PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Homo sapiens)


S-adenosyl-L-methionine binding

description: Binding to S-adenosyl-L-methionine.


name: Molybdenum cofactor biosynthesis (Mus musculus)


name: Exchange of oxygen with sulfur in MoCo (Mus musculus)


name: Molybdenum ion transfer onto molybdopterin (Mus musculus)


name: PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Mus musculus)


name: Cyclisation of GTP to precursor Z (Mus musculus)


name: Molybdenum cofactor biosynthesis (Rattus norvegicus)


name: Molybdenum ion transfer onto molybdopterin (Rattus norvegicus)


name: PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Rattus norvegicus)


name: Cyclisation of GTP to precursor Z (Rattus norvegicus)


name: Exchange of oxygen with sulfur in MoCo (Rattus norvegicus)


name: Molybdenum cofactor biosynthesis (Canis familiaris)


name: Exchange of oxygen with sulfur in MoCo (Canis familiaris)


name: Molybdenum ion transfer onto molybdopterin (Canis familiaris)


name: Cyclisation of GTP to precursor Z (Canis familiaris)


name: PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Canis familiaris)


name: Molybdenum cofactor biosynthesis (Bos taurus)


name: Exchange of oxygen with sulfur in MoCo (Bos taurus)


name: Molybdenum ion transfer onto molybdopterin (Bos taurus)


name: PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Bos taurus)


name: Cyclisation of GTP to precursor Z (Bos taurus)


name: Molybdenum cofactor biosynthesis (Sus scrofa)


name: Exchange of oxygen with sulfur in MoCo (Sus scrofa)


name: Molybdenum ion transfer onto molybdopterin (Sus scrofa)


name: PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Sus scrofa)


name: Cyclisation of GTP to precursor Z (Sus scrofa)


name: Molybdenum cofactor biosynthesis (Danio rerio)


name: Exchange of oxygen with sulfur in MoCo (Danio rerio)


name: PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Danio rerio)


name: Molybdenum cofactor biosynthesis (Xenopus tropicalis)


name: PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Xenopus tropicalis)


name: Cyclisation of GTP to precursor Z (Xenopus tropicalis)


name: Molybdenum cofactor biosynthesis (Drosophila melanogaster)


name: Cyclisation of GTP to precursor Z (Drosophila melanogaster)


name: Exchange of oxygen with sulfur in MoCo (Drosophila melanogaster)


name: PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Drosophila melanogaster)


name: Molybdenum ion transfer onto molybdopterin (Drosophila melanogaster)


name: Molybdenum cofactor biosynthesis (Caenorhabditis elegans)


name: Cyclisation of GTP to precursor Z (Caenorhabditis elegans)


name: Exchange of oxygen with sulfur in MoCo (Caenorhabditis elegans)


name: Molybdenum ion transfer onto molybdopterin (Caenorhabditis elegans)


name: PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Caenorhabditis elegans)


name: Molybdenum cofactor biosynthesis (Dictyostelium discoideum)


name: PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Dictyostelium discoideum)


name: Exchange of oxygen with sulfur in MoCo (Dictyostelium discoideum)


name: Cyclisation of GTP to precursor Z (Dictyostelium discoideum)


name: Molybdenum ion transfer onto molybdopterin (Dictyostelium discoideum)


name: Molybdenum cofactor biosynthesis (Schizosaccharomyces pombe)


name: PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Schizosaccharomyces pombe)


name: Molybdenum cofactor biosynthesis (Saccharomyces cerevisiae)


name: PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Saccharomyces cerevisiae)


name: Molybdenum cofactor biosynthesis (Plasmodium falciparum)


name: PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Plasmodium falciparum)


name: Uptake of dietary cobalamins into enterocytes (Homo sapiens)


name: ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Homo sapiens)


name: Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl (Homo sapiens)


name: Pancreatic proteases degrade TCN1:RCbl (Homo sapiens)


name: CUBN:AMN binds CBLIF:RCbl (Homo sapiens)


name: CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Homo sapiens)


name: Uptake of dietary cobalamins into enterocytes (Mus musculus)


name: ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Mus musculus)


name: Uptake of dietary cobalamins into enterocytes (Rattus norvegicus)


name: CUBN:AMN binds CBLIF:RCbl (Rattus norvegicus)


name: CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Rattus norvegicus)


name: Uptake of dietary cobalamins into enterocytes (Canis familiaris)


name: Pancreatic proteases degrade TCN1:RCbl (Canis familiaris)


name: ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Canis familiaris)


name: Uptake of dietary cobalamins into enterocytes (Bos taurus)


name: ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Bos taurus)


name: CUBN:AMN binds CBLIF:RCbl (Bos taurus)


name: Pancreatic proteases degrade TCN1:RCbl (Bos taurus)


name: CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Bos taurus)


name: Uptake of dietary cobalamins into enterocytes (Sus scrofa)


name: ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Sus scrofa)


name: Pancreatic proteases degrade TCN1:RCbl (Sus scrofa)


name: Uptake of dietary cobalamins into enterocytes (Xenopus tropicalis)


name: Pancreatic proteases degrade TCN1:RCbl (Xenopus tropicalis)


name: Uptake of dietary cobalamins into enterocytes (Drosophila melanogaster)


name: CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Drosophila melanogaster)


name: CBLIF binds RCbl (Drosophila melanogaster)


name: TCN1 binds RCbl (Drosophila melanogaster)


name: CUBN:AMN binds CBLIF:RCbl (Drosophila melanogaster)


name: Uptake of dietary cobalamins into enterocytes (Dictyostelium discoideum)


name: ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Dictyostelium discoideum)


name: Cobalamin (Cbl) metabolism (Homo sapiens)


name: MTRR reduces cob(II)alamin to meCbl (Homo sapiens)


name: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Homo sapiens)


name: MMAA:MUT binds AdoCbl (Homo sapiens)


name: MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Homo sapiens)


name: Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Homo sapiens)


name: MMACHC:cob(II)alamin binds MMADHC (Homo sapiens)


name: MMAB adenosylates cob(I)alamin (Homo sapiens)


name: MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Homo sapiens)


name: Cobalamin (Cbl) metabolism (Mus musculus)


name: MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Mus musculus)


name: Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Mus musculus)


name: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Mus musculus)


name: MMACHC:cob(II)alamin binds MMADHC (Mus musculus)


name: MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Mus musculus)


name: MMAA:MUT binds AdoCbl (Mus musculus)


name: MMAB adenosylates cob(I)alamin (Mus musculus)


name: MTRR reduces cob(II)alamin to meCbl (Mus musculus)


name: Cobalamin (Cbl) metabolism (Rattus norvegicus)


name: MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Rattus norvegicus)


name: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Rattus norvegicus)


name: MMAA:MUT binds AdoCbl (Rattus norvegicus)


name: MMACHC dealkylates RCbl (Rattus norvegicus)


name: MMACHC:cob(II)alamin binds MMADHC (Rattus norvegicus)


name: MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Rattus norvegicus)


name: MTRR reduces cob(II)alamin to meCbl (Rattus norvegicus)


name: MMACHC decyanates CNCbl (Rattus norvegicus)


name: MMAB adenosylates cob(I)alamin (Rattus norvegicus)


name: Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Rattus norvegicus)


name: Cobalamin (Cbl) metabolism (Canis familiaris)


name: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Canis familiaris)


name: MMACHC dealkylates RCbl (Canis familiaris)


name: MTRR reduces cob(II)alamin to meCbl (Canis familiaris)


name: MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Canis familiaris)


name: MMAA:MUT binds AdoCbl (Canis familiaris)


name: MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Canis familiaris)


name: MMACHC:cob(II)alamin binds MMADHC (Canis familiaris)


name: Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Canis familiaris)


name: MMAB adenosylates cob(I)alamin (Canis familiaris)


name: MMACHC decyanates CNCbl (Canis familiaris)


name: MMAA:MUT binds AdoCbl (Bos taurus)


name: MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Bos taurus)


name: MTRR reduces cob(II)alamin to meCbl (Bos taurus)


name: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Bos taurus)


name: MMACHC:cob(II)alamin binds MMADHC (Bos taurus)


name: Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Bos taurus)


name: MMAB adenosylates cob(I)alamin (Bos taurus)


name: MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Bos taurus)


name: MTRR reduces cob(II)alamin to meCbl (Sus scrofa)


name: Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Sus scrofa)


name: MMAB adenosylates cob(I)alamin (Sus scrofa)


name: MMAA:MUT binds AdoCbl (Sus scrofa)


name: MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Sus scrofa)


name: MMACHC:cob(II)alamin binds MMADHC (Sus scrofa)


name: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Sus scrofa)


name: MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Sus scrofa)


name: Cobalamin (Cbl) metabolism (Danio rerio)


name: MMACHC:cob(II)alamin binds MMADHC (Danio rerio)


name: MMAA:MUT binds AdoCbl (Danio rerio)


name: MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Danio rerio)


name: Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Danio rerio)


name: Cobalamin (Cbl) metabolism (Xenopus tropicalis)


name: MMACHC dealkylates RCbl (Xenopus tropicalis)


name: MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Xenopus tropicalis)


name: Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Xenopus tropicalis)


name: MMACHC decyanates CNCbl (Xenopus tropicalis)


name: MMACHC:cob(II)alamin binds MMADHC (Xenopus tropicalis)


name: MMAB adenosylates cob(I)alamin (Xenopus tropicalis)


name: Cobalamin (Cbl) metabolism (Caenorhabditis elegans)


name: MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Caenorhabditis elegans)


name: MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)


name: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Caenorhabditis elegans)


name: MMACHC dealkylates RCbl (Caenorhabditis elegans)


name: MMAB adenosylates cob(I)alamin (Caenorhabditis elegans)


name: MMACHC decyanates CNCbl (Caenorhabditis elegans)


name: MMACHC:cob(II)alamin binds MMADHC (Caenorhabditis elegans)


name: Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Caenorhabditis elegans)


name: MMAA:MUT binds AdoCbl (Caenorhabditis elegans)


name: MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Caenorhabditis elegans)


name: Cobalamin (Cbl) metabolism (Dictyostelium discoideum)


name: MMAB adenosylates cob(I)alamin (Dictyostelium discoideum)


name: MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)


name: MMACHC dealkylates RCbl (Dictyostelium discoideum)


name: MMACHC decyanates CNCbl (Dictyostelium discoideum)


name: MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Dictyostelium discoideum)


name: Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Dictyostelium discoideum)


name: Transport of RCbl within the body (Homo sapiens)


name: LRP2 binds extracellular TCN2:RCbl (Homo sapiens)


name: CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Homo sapiens)


molecular sequestering activity

description: Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.


name: TCN2:RCbl is degraded to release RCbl (Homo sapiens)


name: CD320 binds extracellular TCN2:RCbl (Homo sapiens)


name: TCN2 binds RCbl in the circulation (Homo sapiens)


name: LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Homo sapiens)


name: ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Homo sapiens)


name: ABCC1 transports cytosolic RCbl to extracellular region (Homo sapiens)


name: Transport of RCbl within the body (Mus musculus)


name: ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Mus musculus)


name: ABCC1 transports cytosolic RCbl to extracellular region (Mus musculus)


name: LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Mus musculus)


name: CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Mus musculus)


name: TCN2 binds RCbl in the circulation (Mus musculus)


name: LRP2 binds extracellular TCN2:RCbl (Mus musculus)


name: CD320 binds extracellular TCN2:RCbl (Mus musculus)


name: Transport of RCbl within the body (Rattus norvegicus)


name: LRP2 binds extracellular TCN2:RCbl (Rattus norvegicus)


name: TCN2 binds RCbl in the circulation (Rattus norvegicus)


name: CD320 binds extracellular TCN2:RCbl (Rattus norvegicus)


name: ABCC1 transports cytosolic RCbl to extracellular region (Rattus norvegicus)


name: CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Rattus norvegicus)


name: LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Rattus norvegicus)


name: Transport of RCbl within the body (Canis familiaris)


name: LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Canis familiaris)


name: CD320 binds extracellular TCN2:RCbl (Canis familiaris)


name: ABCC1 transports cytosolic RCbl to extracellular region (Canis familiaris)


name: LRP2 binds extracellular TCN2:RCbl (Canis familiaris)


name: CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Canis familiaris)


name: ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Canis familiaris)


name: TCN2 binds RCbl in the circulation (Canis familiaris)


name: TCN1 binds correnoids in the circulation (Canis familiaris)


name: Transport of RCbl within the body (Bos taurus)


name: LRP2 binds extracellular TCN2:RCbl (Bos taurus)


name: TCN1 binds correnoids in the circulation (Bos taurus)


name: CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Bos taurus)


name: CD320 binds extracellular TCN2:RCbl (Bos taurus)


name: TCN2 binds RCbl in the circulation (Bos taurus)


name: ABCC1 transports cytosolic RCbl to extracellular region (Bos taurus)


name: LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Bos taurus)


name: ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Bos taurus)


name: Transport of RCbl within the body (Sus scrofa)


name: ABCC1 transports cytosolic RCbl to extracellular region (Sus scrofa)


name: CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Sus scrofa)


name: TCN1 binds correnoids in the circulation (Sus scrofa)


name: ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Sus scrofa)


name: CD320 binds extracellular TCN2:RCbl (Sus scrofa)


name: TCN2 binds RCbl in the circulation (Sus scrofa)


name: Transport of RCbl within the body (Xenopus tropicalis)


name: ABCC1 transports cytosolic RCbl to extracellular region (Xenopus tropicalis)


name: TCN1 binds correnoids in the circulation (Xenopus tropicalis)


name: TCN2 binds RCbl in the circulation (Xenopus tropicalis)


name: Transport of RCbl within the body (Drosophila melanogaster)


name: TCN2 binds RCbl in the circulation (Drosophila melanogaster)


name: CD320 binds extracellular TCN2:RCbl (Drosophila melanogaster)


name: TCN1 binds correnoids in the circulation (Drosophila melanogaster)


name: CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Drosophila melanogaster)


name: ABCC1 transports cytosolic RCbl to extracellular region (Drosophila melanogaster)


name: Transport of RCbl within the body (Caenorhabditis elegans)


name: ABCC1 transports cytosolic RCbl to extracellular region (Caenorhabditis elegans)


name: Transport of RCbl within the body (Dictyostelium discoideum)


name: ABCC1 transports cytosolic RCbl to extracellular region (Dictyostelium discoideum)


name: ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Dictyostelium discoideum)


name: Transport of RCbl within the body (Schizosaccharomyces pombe)


name: ABCC1 transports cytosolic RCbl to extracellular region (Schizosaccharomyces pombe)


name: Transport of RCbl within the body (Saccharomyces cerevisiae)


name: ABCC1 transports cytosolic RCbl to extracellular region (Saccharomyces cerevisiae)


name: Metabolism of folate and pterines (Homo sapiens)


name: FOLR2 transports FOLA from extracellular region to cytosol (Homo sapiens)


name: ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)


name: MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Homo sapiens)


name: Cytosolic folate export across the plasma membrane (Homo sapiens)


name: FPGS-2 transforms THF to THFPG (Homo sapiens)


name: 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Homo sapiens)


name: DHFR2 reduces FOLA to DHF (Homo sapiens)


name: 5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Homo sapiens)


name: MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Homo sapiens)


name: SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Homo sapiens)


name: HCOOH translocated from mitochondrial matrix to cytosol (Homo sapiens)


name: MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Homo sapiens)


name: MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Homo sapiens)


name: SLC25A32 transports THF from mitochondrial matrix to cytosol (Homo sapiens)


name: MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)


name: DHF is reduced to tetrahydrofolate (THF) (Homo sapiens)


name: ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)


name: MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Homo sapiens)


name: MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Homo sapiens)


name: MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)


name: SLC46A1 transports FOLA from extracellular region to cytosol (Homo sapiens)


name: SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Homo sapiens)


name: DHFR dimer binds DHFR inhibitors (Homo sapiens)

definition: Inhibition


name: MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Homo sapiens)


name: 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Homo sapiens)


name: Mitochondrial FPGS-1 transforms THF to THFPG (Homo sapiens)


name: FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Homo sapiens)


name: SLC25A32 transports THF from cytosol to mitochondrial matrix (Homo sapiens)


name: PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Homo sapiens)


name: DHFR dimer reduces FOLA to DHF (Homo sapiens)


name: Metabolism of folate and pterines (Mus musculus)


name: MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Mus musculus)


name: ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)


name: SLC25A32 transports THF from mitochondrial matrix to cytosol (Mus musculus)


name: SLC46A1 transports FOLA from extracellular region to cytosol (Mus musculus)


name: SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Mus musculus)


name: Mitochondrial FPGS-1 transforms THF to THFPG (Mus musculus)


name: PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Mus musculus)


name: MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Mus musculus)


name: MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Mus musculus)


name: MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)


name: 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Mus musculus)


name: 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Mus musculus)


name: MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Mus musculus)


name: MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Mus musculus)


name: DHFR2 reduces FOLA to DHF (Mus musculus)


name: SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Mus musculus)


name: DHF is reduced to tetrahydrofolate (THF) (Mus musculus)


name: MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)


name: MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Mus musculus)


name: Cytosolic folate export across the plasma membrane (Mus musculus)


name: 5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Mus musculus)


name: DHFR dimer reduces FOLA to DHF (Mus musculus)


name: FPGS-2 transforms THF to THFPG (Mus musculus)


name: SLC25A32 transports THF from cytosol to mitochondrial matrix (Mus musculus)


name: FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Mus musculus)


name: DHFR dimer binds DHFR inhibitors (Mus musculus)


name: FOLR2 transports FOLA from extracellular region to cytosol (Mus musculus)


name: ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)


name: MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Mus musculus)


name: Metabolism of folate and pterines (Rattus norvegicus)


name: MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Rattus norvegicus)


name: MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Rattus norvegicus)


name: ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)


name: MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)


name: MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Rattus norvegicus)


name: FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Rattus norvegicus)


name: SLC25A32 transports THF from cytosol to mitochondrial matrix (Rattus norvegicus)


name: DHFR dimer reduces FOLA to DHF (Rattus norvegicus)


name: MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Rattus norvegicus)


name: Mitochondrial FPGS-1 transforms THF to THFPG (Rattus norvegicus)


name: ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)


name: MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Rattus norvegicus)


name: SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Rattus norvegicus)


name: SLC46A1 transports FOLA from extracellular region to cytosol (Rattus norvegicus)


name: DHFR dimer binds DHFR inhibitors (Rattus norvegicus)


name: SLC25A32 transports THF from mitochondrial matrix to cytosol (Rattus norvegicus)


name: MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Rattus norvegicus)


name: 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Rattus norvegicus)


name: FPGS-2 transforms THF to THFPG (Rattus norvegicus)


name: FOLR2 transports FOLA from extracellular region to cytosol (Rattus norvegicus)


name: 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Rattus norvegicus)


name: DHF is reduced to tetrahydrofolate (THF) (Rattus norvegicus)


name: Cytosolic folate export across the plasma membrane (Rattus norvegicus)


name: DHFR2 reduces FOLA to DHF (Rattus norvegicus)


name: PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Rattus norvegicus)


name: 5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Rattus norvegicus)


name: MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)


name: MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Rattus norvegicus)


name: SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Rattus norvegicus)


name: Metabolism of folate and pterines (Canis familiaris)


name: ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)


name: PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Canis familiaris)


name: 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Canis familiaris)


name: Cytosolic folate export across the plasma membrane (Canis familiaris)


name: FPGS-2 transforms THF to THFPG (Canis familiaris)


name: ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)


name: 5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Canis familiaris)


name: MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)


name: MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Canis familiaris)


name: SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Canis familiaris)


name: DHF is reduced to tetrahydrofolate (THF) (Canis familiaris)


name: MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Canis familiaris)


name: MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)


name: DHFR2 reduces FOLA to DHF (Canis familiaris)


name: FOLR2 transports FOLA from extracellular region to cytosol (Canis familiaris)


name: MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Canis familiaris)


name: SLC25A32 transports THF from cytosol to mitochondrial matrix (Canis familiaris)


name: MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Canis familiaris)


name: FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Canis familiaris)


name: MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Canis familiaris)


name: MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Canis familiaris)


name: Mitochondrial FPGS-1 transforms THF to THFPG (Canis familiaris)


name: SLC46A1 transports FOLA from extracellular region to cytosol (Canis familiaris)


name: SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Canis familiaris)


name: DHFR dimer reduces FOLA to DHF (Canis familiaris)


name: MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Canis familiaris)


name: SLC25A32 transports THF from mitochondrial matrix to cytosol (Canis familiaris)


name: DHFR dimer binds DHFR inhibitors (Canis familiaris)


name: 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Canis familiaris)


name: Metabolism of folate and pterines (Bos taurus)


name: DHFR dimer binds DHFR inhibitors (Bos taurus)


name: SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Bos taurus)


name: MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)


name: MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)


name: FOLR2 transports FOLA from extracellular region to cytosol (Bos taurus)


name: MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Bos taurus)


name: MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Bos taurus)


name: MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Bos taurus)


name: ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)


name: ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)


name: PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Bos taurus)


name: SLC25A32 transports THF from cytosol to mitochondrial matrix (Bos taurus)


name: FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Bos taurus)


name: Mitochondrial FPGS-1 transforms THF to THFPG (Bos taurus)


name: MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Bos taurus)


name: MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Bos taurus)


name: SLC46A1 transports FOLA from extracellular region to cytosol (Bos taurus)


name: SLC25A32 transports THF from mitochondrial matrix to cytosol (Bos taurus)


name: 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Bos taurus)


name: SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Bos taurus)


name: FPGS-2 transforms THF to THFPG (Bos taurus)


name: 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Bos taurus)


name: MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Bos taurus)


name: DHF is reduced to tetrahydrofolate (THF) (Bos taurus)


name: Cytosolic folate export across the plasma membrane (Bos taurus)


name: DHFR dimer reduces FOLA to DHF (Bos taurus)


name: MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Bos taurus)


name: 5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Bos taurus)


name: Metabolism of folate and pterines (Sus scrofa)


name: SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Sus scrofa)


name: FOLR2 transports FOLA from extracellular region to cytosol (Sus scrofa)


name: 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Sus scrofa)


name: 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Sus scrofa)


name: FPGS-2 transforms THF to THFPG (Sus scrofa)


name: DHF is reduced to tetrahydrofolate (THF) (Sus scrofa)


name: Cytosolic folate export across the plasma membrane (Sus scrofa)


name: 5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Sus scrofa)


name: SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Sus scrofa)


name: MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)


name: MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Sus scrofa)


name: ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)


name: MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Sus scrofa)


name: MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Sus scrofa)


name: DHFR dimer reduces FOLA to DHF (Sus scrofa)


name: ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)


name: PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Sus scrofa)


name: MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)


name: SLC25A32 transports THF from cytosol to mitochondrial matrix (Sus scrofa)


name: DHFR dimer binds DHFR inhibitors (Sus scrofa)


name: MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Sus scrofa)


name: FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Sus scrofa)


name: MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Sus scrofa)


name: Mitochondrial FPGS-1 transforms THF to THFPG (Sus scrofa)


name: MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Sus scrofa)


name: MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Sus scrofa)


name: SLC25A32 transports THF from mitochondrial matrix to cytosol (Sus scrofa)


name: SLC46A1 transports FOLA from extracellular region to cytosol (Sus scrofa)


name: Metabolism of folate and pterines (Danio rerio)


name: ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)


name: MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)


name: MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Danio rerio)


name: SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Danio rerio)


name: MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Danio rerio)


name: MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)


name: 5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Danio rerio)


name: Cytosolic folate export across the plasma membrane (Danio rerio)