name: renal pelvis papillary urothelial carcinoma

description: A papillary transitional cell carcinoma that arises from the renal pelvis.


fallopian tube adenocarcinoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A carcinoma that arises from glandular epithelial cells of the fallopian tube


name: signet ring cell variant cervical mucinous adenocarcinoma

description: A rare cervical mucinous adenocarcinoma characterized by the presence of signet ring cells.


endometrial mixed adenocarcinoma

description: An adenocarcinoma that arises from the endometrium and is characterized by the presence of both type I and type II endometrial adenocarcinoma components. The minor component constitutes at least 5% of the entire tumor.


hobnail hemangioma

description: A hemangioma characterized by the presence of hobnail endothelial cells.


name: female breast upper-outer quadrant cancer


name: renal pelvis/ureter urothelial carcinoma

description: A transitional cell carcinoma that arises from the renal pelvis and ureter.


name: bladder papillary clear cell adenocarcinoma

description: A rare morphologic variant of bladder adenocarcinoma characterized by the presence of malignant glandular epithelial cells and clear cells forming a papillary pattern.


name: paranasal sinus mucoepidermoid carcinoma

description: A rare carcinoma that arises from the paranasal sinus. It is characterized by the presence of epidermoid cells, mucus producing cells, and cells of intermediate type.


early invasive cervical adenocarcinoma

description: A cervical adenocarcinoma with minimal stromal invasion. The risk of local lymph node metastasis is insignificant and the prognosis is excellent.


name: ductal breast carcinoma in situ and lobular carcinoma in situ

description: The co-existence of ductal and lobular carcinoma in situ in the breast, without evidence of stromal invasion.


renal cell carcinoma

description: A carcinoma that arises from glandular epithelial cells of the kidney


keratinizing squamous cell carcinoma

description: Squamous cell carcinomas with morphologically prominent production of keratin.


name: metastatic carcinoma in the adrenal medulla

description: A carcinoma that has spread to the adrenal medulla from an adjacent or distant anatomic site.


adenoid cystic carcinoma

description: A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid cystic carcinomas mostly occur in the salivary glands. Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread is characteristic.


Wolffian adnexal tumor

description: A benign or malignant epithelial neoplasm of probable Wolffian origin. It predominantly arises from the broad ligament and presents as a unilateral adnexal mass.


urethral villous adenoma

description: An epithelial neoplasm of the urethra, which is morphologically characterized by the presence of a villous architectural pattern.


eccrine porocarcinoma

description: A carcinoma with eccrine differentiation arising from the sweat glands. It may arise de novo or as a malignant transformation of a pre-existing poroma. It usually grows in the legs, buttocks, feet, and trunk and usually presents as an ulcerative plaque. It is characterized by the presence of intraepidermal and dermal nests of malignant epithelial cells. It may recur after excision and metastasize to the lymph nodes and less frequently to distal anatomic sites.


malignant type A thymoma

description: A type A thymoma which is characterized by an aggressive clinical course (capsular invasion, infiltration of the surrounding tissues) and can metastasize.


splenic hemangioma

description: A hemangioma arising from the spleen.


Gorham-Stout disease

description: Gorham-Stout disease (GSD) is a rare disease of massive osteolysis associated with proliferation and dilation of lymphatic vessels. GSD may affect any bone in the body and can be monostotic or polyostotic. Symptoms at presentation are dependent upon the location(s) of the disease; the most common symptom is localized pain. The disease may be discovered after a pathological fracture.


atypical lobular breast hyperplasia

description: Lobular neoplasia characterized by lobular epithelial proliferation that does not completely fill the lobular unit of the breast.


middle ear carcinoma

description: A carcinoma that arises from epithelial cells of the middle ear


angiokeratoma

description: A vascular lesion in the papillary dermis resulting from ectasia of pre-existing vessels. It is associated with secondary proliferative changes in the overlying epidermis (hyperkeratosis). It can present with widespread lesions (angiokeratoma corporis diffusum, often associated with inborn errors of metabolism) or as a localized lesion (angiokeratoma of Fordyce, angiokeratoma circumscriptum, and angiokeratoma of Mibelli).


vulvar glandular neoplasm

description: A benign or malignant neoplasm that arises from the vulva and is composed of glandular epithelial cells. Representative examples include adenoma of the minor vestibular glands, Bartholin gland adenoma, and Bartholin gland adenocarcinoma.


name: childhood adrenal gland pheochromocytoma

description: A rare pheochromocytoma of the adrenal gland that occurs during childhood.


paranasal sinus carcinoma

description: A malignant epithelial neoplasm arising in the paranasal sinus.


infiltrating urothelial carcinoma

description: A invasive carcinoma that involves the urothelium.


uterine ligament serous adenocarcinoma

description: A rare serous adenocarcinoma that arises from the uterine ligament.


middle ear squamous cell carcinoma

description: A rare squamous cell carcinoma that arises from the middle ear.


cystic renal cell carcinoma

description: Cystic renal cell carcinoma includes any malignant neoplasm of renal tubular epithelium which presents as a fluid-filled mass. Approximately 15 per cent of cases of renal cell carcinoma will be cystic on radiologic and pathologic examination. The clinical features of cystic renal cell carcinoma are similar to those which are solid. The radiographic and pathologic findings of cystic renal cell carcinoma are often more confusing and less specific than the findings of renal cell carcinoma which are predominantly solid. There are four basic pathologic mechanisms resulting in cystic renal cell carcinoma: intrinsic multiloculated growth; intrinsic unilocular growth (cystadenocarcinoma); cystic necrosis; and origin from the epithelial lining of a preexisting simple cyst. There are three basic radiologic patterns of cystic renal cell carcinoma: unilocular cystic mass, multiloculated cystic mass, and discrete mural nodule in a cystic mass. Cystic renal cell carcinoma is often extremely difficult to differentiate from non-neoplastic, benign neoplastic, and other malignant neoplastic masses utilizing radiologic studies alone. This review presents the clinical, pathologic, and radiographic features of cystic renal cell carcinoma and discusses its radiologic differential diagnosis.


breast adenomyoepithelioma

description: A usually benign tumor arising from the breast. It is characterized by the proliferation of cells with myoepithelial differentiation around spaces which are lined by epithelial cells. Rarely, the epithelial and/or myoepithelial cells may undergo malignant transformation. Cases with malignant transformation may follow an aggressive clinical course, including recurrences and local and distant metastases.


aniridia 3

description: Any isolated aniridia in which the cause of the disease is a mutation in the TRIM44 gene.


hemangioblastoma

description: Hemangioblastoma is a rare, benign, highly vascularized tumor of the central nervous system, most often located in the cerebellum or spinal cord, presenting in adulthood and manifesting with dizziness, nausea, malaise, headache, bladder or bowel dysfunction, numbness, weakness and pain in the upper or lower extremities, and often associated with von Hippel-Lindau disease (VHL). Exceptional cases of hemangioblastoma arising outside of the central nervous system have been reported.


name: mucinous tubular and spindle renal cell carcinoma

description: A low grade carcinoma of the kidney characterized by the presence of tubules which are separated by mucinous stroma. Often the tubular structures have a spindle cell appearance. Patients are usually asymptomatic and occasionally they may present with hematuria or flank pain.


papillary carcinoma of the penis

description: A squamous cell carcinoma that arises from the penis and is characterized by the presence of a papillary growth pattern.


seminal vesicle cystadenoma

description: A rare benign cystadenoma that arises from the seminal vesicle.


name: normal breast-like subtype of breast carcinoma

description: A biologic subset of breast carcinoma defined by high expression of many genes expressed by adipose and other non-epithelial tissues.


facial arteriovenous malformation

description: Facial arteriovenous malformation is a rare vascular anomaly characterized by abnormal communication between arteries and veins, bypassing the capillary bed, located in the facial area. Lesions may be asymptomatic or may manifest with pain, ulceration, pulsation, tinnitus, minor bleeding or potentially life-threatening hemorrhage, blurred vision, impaired hearing, headache, paresthesia, enlargement of facial bones with intraosseous lesions, intraosseous hemangiomas, and speech, breathing and swallowing difficulties, as well as neuropathy.


transitional cell papilloma

description: A benign papillary neoplasm composed of transitional cells which show preservation of the nuclear polarity.


thymoma type A

description: A thymic epithelial neoplasm characterized by the presence of spindle and/or oval neoplastic epithelial cells. Lymphocytic infiltration is minimal or absent. It may be associated with myasthenia gravis or pure red cell aplasia. The majority of cases occur in the anterior mediastinum as Masaoka stage I tumors. Approximately 20% of the cases occur as stage II or stage III tumors. Type A thymoma generally behaves as a benign tumor and the overall survival is reported to be 100% at 5 and 10 years.


encapsulated thymoma

description: A thymoma that is confined within the capsule and may display benign or malignant morphologic characteristics.


inverted urothelial papilloma

description: An endophytic lesion in the urinary tract which shares several morphologic features with urothelial papilloma. This lesion may recur after complete excision. Transitional cell carcinomas may arise within inverted urothelial papillomas.


uterine ligament adenocarcinoma

description: A rare adenocarcinoma that arises from the uterine ligament.


endometrial squamous cell carcinoma

description: A primary carcinoma of the endometrium characterized by the presence of malignant squamous cells.


adrenal cortex adenoma

description: A benign neoplasm that can arise from any of the adrenal cortical layers. It can be associated with the overproduction of glucocorticoids (Cushing's syndrome), androgenic or estrogenic steroids (adrenogenital syndrome), or mineralocorticoids (Conn's syndrome). (Sternberg Diagnostic Surgical Pathology, 3rd ed.)


glandular cell neoplasm

description: A benign or malignant, primary or metastatic epithelial neoplasm affecting the glandular cells.


name: eosinophilic variant of chromophobe renal cell carcinoma

description: A variant of chromophobe renal cell carcinoma in which more than 80% of the malignant cells have granular, eosinophilic cytoplasm.


ocular sebaceous carcinoma

description: Ocular sebaceous carcinoma is a rare condition and accounts for 1% to 5.5% of eyelid malignancies and is the third most common eyelid malignancy after basal cell and squamous cell carcinoma. It usually affects elderly women, has a high rate of local recurrence, and a tendency to regional and distant metastases.


name: lip and oral cavity squamous cell carcinoma

description: A squamous cell carcinoma arising from the lip or the oral cavity. The oral cavity squamous cell carcinoma usually arises from the buccal mucosa, tongue, or gums. It occurs predominantly in adults who use tobacco and alcohol and has a tendency to metastasize early to lymph nodes.


ovarian clear cell cystadenocarcinoma

description: A malignant glandular epithelial neoplasm arising from the ovary. It is characterized by the presence of clear and hobnail cells and cystic structures.


prostatic urethra urothelial carcinoma

description: An urothelial carcinoma that arises from the urothelial lining of the prostatic urethra.


Bartholin gland adenomyoma

description: A rare, benign neoplasm that arises from the Bartholin gland and is characterized by the presence of a fibromuscular stroma and glands lined by mucin-secreting epithelial cells, arranged in a lobular architecture.


thymoma type B3

description: Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated carcinoma. The majority of cases occur in the anterior mediastinum as Masaoka stage II or stage III tumors. It is almost always invasive, it recurs frequently, and metastasizes in approximately 20% of the cases.


skin carcinoma in situ

description: A in situ carcinoma that involves the zone of skin.


intracystic papillary adenoma

description: A papillary epithelial neoplasm arising in a cystically dilated breast duct.


name: uterine ligament endometrioid adenocarcinoma

description: A rare endometrioid adenocarcinoma that arises from the uterine ligament. Some of the reported cases were associated with endometriosis.


cutaneous Paget disease

description: A skin carcinoma that is characterized by infiltration of the skin by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli.


mucoepidermoid carcinoma

description: A carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It can occur in several anatomic sites, including parotid gland, oral cavity, paranasal sinus, skin, breast, lung, larynx, and lacrimal ducts. It is classified as low or high grade.


sebaceous breast carcinoma

description: A very rare breast adenocarcinoma with sebaceous differentiation.


ethmoid sinus squamous cell carcinoma

description: A squamous cell carcinoma that arises from the mucosal epithelial surface of the ethmoid sinus. Patients may present with nasal fullness, obstruction, and/or epistaxis.


lymph node carcinoma

description: A lymph node cancer that has material basis in abnormally proliferating cells derives from epithelial cells.


name: rapidly involuting congenital hemangioma

description: Rapidly involuting congenital hemangiomas (RICH) are a distinctive type of congenital hemangioma that are fully formed in utero and differ from non-involuting congenital haemangiomas (NICH) mainly because they undergo rapid postnatal involution.


fallopian tube papilloma

description: A benign epithelial neoplasm that arises from the fallopian tube. It is characterized by the presence of fibrovascular stalks lined by serous epithelial cells.


vulvar inverted follicular keratosis

description: Seborrheic keratosis that arises from follicular structures in the vulva. It is characterized by the presence of prominent squamous eddies.


A lithostathine-1-beta that is encoded in the genome of human.


name: ephrin type-A receptor 3, signal peptide removed phosphorylated 1 (human)

description: An ephrin type-A receptor 3 (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 596 and 602 of the amino acid sequence represented by UniProtKB:P29320. UniProtKB:P29320, 21-983, Tyr-596/Tyr-602, MOD:00048.


name: YCIA_ECOLI Acyl-CoA thioester hydrolase YciA (sprot)

description: An acyl-CoA thioester hydrolase YciA that is encoded in the genome of Escherichia coli K-12.


acyl-CoA thioester hydrolase YciA

A protein that is a translation product of the Escherichia coli K-12 yciA gene or a 1:1 ortholog thereof.


name: MED17_CANAL Mediator of RNA polymerase II transcription subunit 17 (sprot)

description: A protein that is a translation product of the SRB4 gene in Candida albicans SC5314.


name: symbiont-mediated perturbation of host actin cytoskeleton via actin crosslinking

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by actin crosslinking the host actin filaments. The host is defined as the larger of the organisms involved in a symbiotic interaction.


prunetin 4'-O-glucoside

A glycosyloxyisoflavone that is the 4'-O-beta-D-glucoside of prunetin.


isoflavonoid

Any 1-benzopyran with an aryl substituent at position 3. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.


A methoxyisoflavone that is isoflavone substituted by a methoxy group at position 5, a hydroxy group at position 7 and methyl groups at positions 6 and 8. It has been isolated from the buds of Cleistocalyx operculatus and has been shown to exhibit inhibitory effects on the viral neuraminidases from two influenza viral strains,H1N1 and H9N2.


vestitone

A hydroxyisoflavanone that is isoflavanone substituted by hydroxy groups at positions 7 and 2' and a methoxy group at position 4'.


daidzein monosulfate

An aryl sulfate obtained by sulfation of one of the phenolic hydroxy groups of daidzein.


dalpatein

An methoxyisoflavone having methoxy substituents at the 6- and 2'-positions, a hydroxy group at position 7 and a methylenedioxy moiety at the 4'- and 5'-positions.


isoflavones

Any isoflavonoid with a 3-aryl-1-benzopyran-4-one (3-aryl-4H-chromen-4-one) skeleton and its substituted derivatives.


WIGHTEONE

A member of the class of  7-hydroxyisoflavones that is isoflavone substituted by hydroxy groups at positions 5, 7 and 4' and a prenyl group at position 6. It has been isolated from Ficus mucuso.


kievitone

A hydroxyisoflavanone that is isoflavanone with hydroxy substituents at positions 5, 7, 2' and 4' and a prenyl group at position 8.


A 7,2'-dihydroxy-4'-methoxyisoflavanol that has R configuration at position 3.


A hydroxyisoflavanone bearing three hydroxy substituents at positions 2, 5 and 7 in addition to a methoxy substituent at position 4'.


CASTANIN

A  4'-methoxyisoflavone that is isoflavone substituted by methoxy groups at positions 6 and 4' and a hydroxy group at position 7.


PIERREIONE A

A  methoxyisoflavone that is isoflavone substituted by methoxy groups at positions 5 and 3', a 2R,3-dihydroxy-3-methylbutoxyl group at position 4' and a dimethylpyran ring fused across positions 6 and 7. Isolated from Antheroporum pierrei, it exhibits antineoplastic activity.


5-deoxyglyasperin F

A hydroxyisoflavanone  that is 2,3-dihydro-2'H,4H-3,8'-bichromen-4-one substituted by hydroxy groups at positions 5' and 7 and geminal methyl groups at position 2'. Isolated from the roots of Erythrina lysistemon, it exhibits anti-HIV activity.


malonylglycitin

A glycosyloxyisoflavone that is glycitin substituted by a  malonyl group at position 6''.


ISOFLAVANONE

Isoflavone in which the double bond between positions 2 and 3 has been reduced to a single bond.


glycosyloxyisoflavone

A member of the class of isoflavones having one or more glycosyl residues attached at unspecified positions.


malonylgenistin

A  glycosyloxyisoflavone that is genistin in which the hydroxy hydrogen at position 6'' has been replaced by a malonyl group.


CORYLIN

A member of the class of 7-hydroxyisoflavones that is isoflavone substituted by hydroxy groups at positions 5, 7 and 4' and a prenyl group at position 3'. It has been isolated from Ficus mucuso.


MUCRONULATOL

A methoxyisoflavan that is (S)-isoflavan substituted by methoxy groups at positions 2' and 4' and hydroxy groups at positions 7 and 3' respectively.


(+)-vestitol

The S-enantiomer of vestitol.


(+/-)-FUROWANIN B

A hydroxyisoflavone that is 8,9-dihydro-4H-furo[2,3-h]chromen-4-one substituted by a hydroxy group at position 5, a 3,4-dihydroxyphenyl group at position 3, a 2-hydroxypropan-2-yl group at position 8 and a prenyl group at position 6. Isolated from Millettia pachycarpa, it exhibits anti-estrogenic activity.


HISPAGLABRIDIN A

A member of the class of  hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' , a  3-methylbut-2-en-1-yl group at position 3' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively.


A member of the class of  7-hydroxyisoflavones that is genistein substituted by prenyl groups at positions 6 and 8. It has been isolated from Derris scandens and Glycyrrhiza uralensis.


A member of the class of hydroxyisoflavans that is isoflavan-4,7-diol which is substituted by a hydroxy group at the 2' position and by a methylenedioxy group at the 4'-5' positions (the R,R stereoisomer).


ipriflavone

A member of the class of isoflavones that is isoflavone in which the hydrogen at position 7 is replaced by an isopropoxy group. A synthetic isoflavone, it was formerly used for the treatment of osteoporosis, although a randomised controlled study failed to show any benefit. It is still used to prevent osteoporosis in post-menopausal women.


PIERREIONE D

A methoxyisoflavone that is isoflavone substituted by a methoxy group at position 3', a prenyloxy group at position 4' and a dimethylpyran ring fused across positions 6 and 7. Isolated from Antheroporum pierrei, it exhibits antineoplastic activity.


licoricone

A  hydroxyisoflavone which is isoflavone substituted by hydroxy groups at positions 7 and 6', methoxy groups at positions 2' and 4' and a prenyl group at position 3'. It has been isolated from Glycyrrhiza uralensis.


MUCUSISOFLAVONE B

A hydroxyisoflavone, isoflavone dimer obtained from Ficus mucuso.


torvanol A hydrogen sulfate

A methoxyisoflavan that is isoflavan substituted by a hydroxy group at position 2', methoxy groups at positions 6 and 3', a 2-carboxyethenyl group at position 5' and a sulfoxy group at position 4.


puerarin xyloside

A hydroxyisoflavone that is puerarin substituted by an alpha-D-xylopyranosyl residue at position 7 via a glycosidic linkage.


(-)-sativan

A  methoxyisoflavan that is (R)-isoflavan substituted by methoxy groups at positions 2' and 4' and a hydroxy group at position 7.


A member of the class of 7-hydroxyisoflavones that is 3-phenyl-4H-chromen-4-one which is substituted by a hydroxy group at position 7 and chloro groups at positions 2' and 4'. It is a SIRT1 activator.


A member of the class of 7-hydroxyisoflavones that is 7,4'-dihydroxyisoflavone substituted by a methoxy group at position 3'. It is isolated from the heart woods of Maackia amurensis subsp buergeri and Dalbergia louveli and exhibits antiplasmodial ativity.


methoxyisoflavan

Any member of the class of isoflavans in which one or more ring hydrogens are replaced by methoxy groups.


Any methoxyisoflavone which has a methoxy group at the 4-position of the phenyl substituent.


hydroxyisoflavanone

Any member of the class of isoflavanones with at least one hydroxy substituent.


A hydroxyisoflavone that is isoflavone substituted by a hydroxy group at position 7 and methoxy groups at the 2', 4' and 5' positions.


A glycosyloxyisoflavone that is calycosin substituted by a beta-D-glucopyranosyl residue at position at 7 via a glycosidic linkage.


prunetin

A hydroxyisoflavone that is  genistein  in which the hydroxy group at position 7 is replaced by a methoxy group.


A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone with additional hydroxy groups at positions 5, 3' and 4' and a prenyl group at position 2'. Isolated from the roots of Psorothamnus arborescens, it exhibits antileishmanial activity.


compounds having a coumarin skeleton and having an aryl structure at the 3-position


A 7-hydroxyisoflavone that is daidzein  substituted by a hydroxy group at position 3'.


name: acetic acid (4-oxo-3-phenyl-1-benzopyran-7-yl) ester


A member of the class of isoflavans that is isoflavan-4-ol substituted at positions 7 and 2' by hydroxy groups and at position 4' by a methoxy group.


glycitin

A glycosyloxyisoflavone that is isoflavone substituted by a methoxy group at position 6, a hydroxy group at position 4' and a  beta-D-glucopyranosyloxy group at position 7.


UNCINANONE A

A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by additional hydroxy groups at positions 5, 2' and 4' and a prenyl group at position 6.


GLYASPERIN D

A member of the class of  hydroxyisoflavans that is  (R)-isoflavan substituted by hydroxy groups at positions 2' and 4', methoxy groups at positions 5 and 7 and a prenyl group at position 6. It has been isolated from Glycyrrhiza uralensis.


A hydroxyisoflavone that is daidzein bearing an additional hydroxy substituent at position 6.


talosin A

A  glycosyloxyisoflavone that is  genistein attached to a alpha-L-6-deoxy-talopyranosyl residue at position 7 via a glycosidic linkage. Isolated from Kitasatospora kifunensis, it exhibits antifungal activity.


isowigtheone hydrate

A member of the class of 7-hydroxyisoflavones that is isoflavone substituted by hydroxy groups at positions 5, 7 and 4' and a 3-hydroxy-3-methylbutyl moiety at position 3'. Isolated from the root barks of Brosimum utile, it exhibits cytotoxicity  against cell lines like MCF7 (human breast carcinoma), PC3 (human prostate carcinoma), HT29 (human colon cancer) and human dermis fibroblasts.


2'-hydroxybiochanin A

A methoxyisoflavone in which the methoxy group is located at position 4' together with three additional hydroxy substituents at positions 2' 5 and 7.


Any hydroxyisoflavone which has a hydroxy group at the 2-position of the phenyl substituent.


piscerythramine

A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 5, 7 and 3', prenyl groups at positions 2' and 6', a methoxy group at position 5' and an amino group at position 4'.


biochanin A

A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis.


sophoraisoflavanone A

A hydroxyisoflavanone that is isoflavanone substituted by hydroxy groups at positions 5, 7 and 4', a methoxy substituent at position 2' and a prenyl group at position 3'.


malonyldaidzin

A glycosyloxyisoflavone that is  daidzein substituted by a 6-O-(carboxyacetyl)-beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage.


betavulgarin

A hydroxyisoflavone that is isoflavone substituted by a hydroxy group at position 2', a methoxy group at position 5 and a methylenedioxy group across positions 6 and 7 respectively.


CALYCOSIN

A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3' position and a methoxy group at the 4' position.


genistein 8-C-glucoside

A C-glycosyl compound that is  genistein substituted by a beta-D-glucopyranosyl residue at position 8 via a C-glucosidic linkage.


A hydroxyisoflavanone that is 2,3-dihydrogenistein with a hydroxy substituent at position 2.


A 7-hydroxyisoflavone that is daidzein in which the aromatic hydrogen at position 8 has been replaced by a prenyl group.


A member of the class of hydroxyisoflavans that is isoflavan-4-ol which is substituted at positions 7, 2' and 4' by hydroxy groups (the 3R,4R stereoisomer).


name: acetic acid [5-acetyloxy-3-(4-methoxyphenyl)-4-oxo-1-benzopyran-7-yl] ester


A glycosyloxyisoflavone that is the 2'',4'',6''-O-triacetyl- derivative of glycitin.


Any member of the class of hydroxyisoflavans that has a hydroxy substituent located at position 2 and 3R-stereochemistry.


A member of the class of 7-hydroxyisoflavones that is isoflavone substituted by hydroxy groups at positions 5, 7 and 2' and methyl group at positions 6 and 8. It has been isolated from Pisonia aculeata.


PISONIANONE

A methoxyisoflavone that is isoflavone substituted by a methoxy group at position 6, a methyl group at position 8 and hydroxy groups at positions 5, 7 and 2'. It has been isolated from Pisonia aculeata.


The diastereomer of 7,2'-dihydroxy-4'-methoxyisoflavanol that has 3R,4R-configuration.


formononetin 7-O-rutinoside

A 4'-methoxyisoflavone that is the 7-O-rutinosyl derivative of formononetin.


A hydroxyisoflavanone that is isoflavanone bearing  hydroxy groups at the 2 and 7  positions, and a methoxy group at the 4' position.


DAIDZIN

A glycosyloxyisoflavone that is  daidzein attached to a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage. It is used in the treatment of alcohol dependency (antidipsotropic).


LICORICIDIN

A member of the class of hydroxyisoflavans that is R-isoflavan with hydroxy groups at positions 7, 2' and 4', a methoxy group at position 5 and prenyl groups at positions 6 and 3'. Isolated from Glycyrrhiza uralensis, it exhibits antibacterial activity.


semilicoisoflavone B

A member of the class of 7-hydroxyisoflavones that is 2',2'-dimethyl-2'H,4H-3,6'-bichromen-4-one substituted by hydroxy groups at positions 5, 7 and 8'. It has been isolated from Glycyrrhiza uralensis.


genistin 7-O-gentiobioside

A glycosyloxyisoflavone that is genistein substituted by a 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside group at position 7.


MUCUSISOFLAVONE A

A hydroxyisoflavone, isoflavone dimer obtained from Ficus mucuso.


DIHYDROBIOCHANIN A

A hydroxyisoflavanone that is the 2,3-dihydro derivative of biochanin A.


LESPEFLORIN D1

A hydroxyisoflavanone that is isoflavanone substituted by hydroxy groups at positions 7 and 4', a methoxy group at position 2' and prenyl groups at positions 8 and 3'. Isolated from the roots of Lespedeza floribunda, it acts as a melanin synthesis inhibitor.


Any hydroxyisoflavone which has a hydroxy group at the 4-position of the phenyl substituent.


A monosaccharide derivative that is (R)-isoflavan substituted by a hydroxy group substituted at position 2', methoxy groups at positions 3' and 4' and a beta-D-glucopyranosyloxy group at position 7 respectively.


DIHYDROGENISTIN

A hydroxyisoflavanone that is dihydrogenistein in which the phenolic hydrogen at position 7 has been replaced by a beta-D-glucosyl residue.


IRIDIN

A glycosyloxyisoflavone that is  irigenin substituted by a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage.


methoxyisoflavanone

Members of the class of isoflavanones with at least one methoxy substituent.


talosin B

A  glycosyloxyisoflavone that is  genistein attached to alpha-L-6-deoxy-talopyranosyl residues at positions 7 and 4' respectively. Isolated from Kitasatospora kifunensis, it exhibits antifungal activity.


A hydroxyisoflavanone that is 2,3-dihydroneobavaisoflavone with an additional hydroxy group at position 2'. Isolated from Erythrina lysistemon, it exhibits anti-HIV activity.


lotisoflavan

A hydroxyisoflavan that is isoflavan substituted by hydroxy groups at positions 2' and 4' and methoxy groups at positions 5 and 7 respectively.


A hydroxyisoflavanones that is isoflavanone bearing hydroxy groups at the 2, 7 and 4' positions, with R and S configurations at C-2 and C-3 respectively.


A 2,7-dihydroxy-4'-methoxyisoflavanone in which positions 2 and 3 have R- and S-configuration respectively.


methoxyisoflavone

Members of the class of isoflavones with at least one methoxy substituent.


7-HYDROXY ISOFLAVONE

The simplest member of the class of 7-hydroxyisoflavones that is isoflavone with a hydroxy substituent at position 7.


name: 4-methyl-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid [3-(4-nitrophenyl)-4-oxo-1-benzopyran-7-yl] ester


(S)-isoflavan

The (S)-enantiomer of isoflavan.


A methoxyisoflavone that is isoflavone substituted by a methoxy group at position 7.


A  glycosyloxyisoflavone that is irilone attached to a  6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl moiety at position 4' via a glycosidic linkage. Isolated from Iris pseudopumila, it exhibits antioxidant activity.


A glycosyloxyisoflavone that is  formononetin attached to a 6-O-(carboxyacetyl)-beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage.


A hydroxyisoflavanone that is 2,3-dihydrodaidzein with an additonal hydroxy substituent at position 2'.


A hydroxyisoflavanone that is isoflavanone with hydroxy substituents at positions 2, 7 and 4'.


A member of the class of 7-hydroxyisoflavones that is pseudobaptigenin  substituted by hydroxy group at position 5.


conferol B

A member of the class of isoflavans that is isoflavan with a hydroxy group at position 4, a methyl group at position 7 and a methoxy group at position 2'   (the 3R,4S stereoisomer). It is isolated from Caragana conferta and exhibits significant anti-inflammatory activity in the respiratory burst assay.


PHASEOLLINISOFLAVAN

A member of the class of  hydroxyisoflavans that is (3R)-3,4-dihydro-2H,2'H-3,6'-bichromene substituted by two methyl groups at positions 2' and 2' and hydroxy groups at positions 5' and 7 respectively.


A methoxyisoflavan that is (S)-isoflavan substituted by methoxy groups at positions 6 and 3' and hydroxy groups at positions 4 and 4'. It has been isolated from Taxus yunnanensis and exhibits inhibitory activity against CYP3A4.


ONONIN

A 4'-methoxyisoflavone that is formononetin attached to a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.


vestitol

A member of the class of  hydroxyisoflavans that is isoflavan substituted by hydroxy groups at positions 7 and 2' and a methoxy group at position 4'. Isolated from Glycyrrhiza uralensis, it exhibits anti-inflammatory activity.


IRIGENIN

A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 5, 7 and 3' and methoxy groups at positions 6, 4' and 5' respectively.


Any methoxyisoflavone that has a methoxy group at the 7-position of the isoflavone moiety.


erylatissin A

A member of the class of 7-hydroxyisoflavones in which isoflavone is substituted by hydroxy groups at the 7 and 3' positions, a methoxy group at the 4' position and a prenyl group at position 5'. Isolated from the stem wood of Erythrina latissima, it exhibits antimicrobial and radical scavenging activities.


A member of the class of 7-hydroxyisoflavones in which isoflavone is substituted by hydroxy groups at the 5, 7, and 3' positions, and by a methoxy group at the 4' position.


daidzein

A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4'.


A hydroxyisoflavone that is luteone in which the hydroxy group at position 7 is replaced by a methoxy group.


MILLEWANIN G

A member of the class of 7-hydroxyisoflavones that is isoflavone substituted by hydroxy groups at positions 5, 7, 3' and 4', a prenyl group at position 8 and a 2-hydroxy-3-methylbut-3-enyl moiety at position 6. Isolated from the leaves of Millettia pachycarpa, it exhibits antiestrogenic activity.


ferreirin

A hydroxyisoflavanone that is isoflavanone substituted by hydroxy groups at positions 5, 7 and 2' and a methoxy group at position 4' respectively.


A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 3' and 4'. It has been isolated from Penicillium purpurogenum.


A dihydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 7 and 4' and a 3-oxo-beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage.


A glycosyloxyisoflavone that is 7-hydroxyisoflavone attached to a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage.


A glycosyloxyisoflavone that is daidzein in which the phenolic hydrogen at position 7 has been replaced by a 6-O-acetyl-beta-D-glucosyl residue.


tectorigenin

A methoxyisoflavone that is  isoflavone substituted by a methoxy group at position 6 and hydroxy groups at positions 5, 7 and 4' respectively.


licorisoflavan A

A member of the class of  hydroxyisoflavans that is the 7-O-methyl derivative of licoricidin. Isolated from Glycyrrhiza uralensis, it exhibits antibacterial activity.


hydroxyisoflavans

A member of the class of isoflavans in which one or more ring hydrogens are replaced by hydroxy groups.


dihydrogenistein

A hydroxyisoflavanone comprising isoflavanone carrying three hydroxy substituents at positions 5, 7 and 4'.


CAJANOL

A  hydroxyisoflavanone that is (3S)-isoflavanone substituted by hydroxy groups at positions 5 and 4' and methoxy groups at positions 7 and 2' respectively. It has been isolated from Crotalaria lachnophora.


dihydrodaidzein

A hydroxyisoflavanone that is isoflavanone carrying two hydroxy substituents located at positions 4' and 7.


A hydroxyisoflavone that is daidzein bearing an additional hydroxy substituent at position 2'.


name: Isoflavone base + 1o, 1meo, o-hex+c7h12no


Any member of the class of hydroxyisoflavans that has two hydroxy substituents located at positions 2' and 4 as well as 3R,4R-stereochemistry.


ISOFORMONENTIN

A methoxyisoflavone that is isoflavone substituted at positions 4' and 7 by hydroxy and methoxy groups respectively.


A 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavone having four methoxy substituents at the 2'-, 4'-, 5'- and 6-positions.


licoisoflavone A

A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by additional hydroxy groups at positions 5, 2' and 4' and a prenyl group at position 3'.


FORMONONETIN

A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'.


PIERREIONE C

A methoxyisoflavone that is isoflavone substituted by methoxy groups at positions 5 and 3', a prenyloxy group at position 4' and a dimethylpyran ring fused across positions 6 and 7. Isolated from Antheroporum pierrei, it exhibits antineoplastic activity.


ISOFLAVONE

A simplest member of the class of isoflavones  that is 4H-chromen-4-one in which the hydrogen at position 3 is replaced by a phenyl group.


A methoxyisoflavone that is isoflavone substituted by methoxy groups at positions 5, 6, 7 and 8 and methylenedioxy group across positions 3' and 4'.


genistein

A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.


A glycosyloxyisoflavone that is glycitin carrying an acetyl substituent at position 6 on the glucose moiety.


puerarin

A hydroxyisoflavone that is  isoflavone substituted by hydroxy groups at positions 7 and 4' and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage.


GLABRIDIN

A member of the class of  hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively.


A pseudobaptigenin that is pseudobaptigenin substituted by a hydroxy groups at position 2'.


oxoisoflavone

A member of the class of isoflavones with at least one oxo substituent.


(R)-isoflavan

The (R)-enantiomer of isoflavan.


A 7,2'-dihydroxy-4'-methoxyisoflavanol that has 3S,4R configuration.


dihydrolicoisoflavone A

A member of the class of 7-hydroxyisoflavones that is the 2,3-dihydro derivative of licoisoflavone A. It has been isolated from Glycyrrhiza uralensis.


ALLOLICOISOFLAVONE A

A  hydroxyisoflavone that is isoflavanone substituted by hydroxy groups at positions 5, 7, 2' and 4' and a prenyl group at position 5. It has been isolated from Glycyrrhiza uralensis.


irilone

A hydroxyisoflavone that is 6,7-methylenedioxyisoflavone substituted by hydroxy groups at positions 5 and 4'.


A  methoxyisoflavan that is isoflavan carrying a double bond across positions 3 and 4, methoxy groups at positions 7 and 4' and methyl groups at positions 2, 2 and 4 respectively.


2'-unsubstituted isoflavones

An isoflavone that has an H at position 2'


millewanin H

A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 5, 7, 3' and 4', a prenyl group at position 6 and a 2-hydroxy-3-methylbut-3-enyl moiety at position 8. Isolated from the leaves of Millettia pachycarpa, it exhibits antiestrogenic activity.


GLYCYRIN

A member of the class of coumarins that is coumarin substituted by methoxy groups at positions 5 and 7, a prenyl group at position 6 and a 2,4-dihydroxyphenyl group at position 3. Isolated from Glycyrrhiza uralensis, it exhibits antibacterial activity.


A a methoxyisoflavone that is a 7-methoxyisoflavone compound arising from enzyme-mediated epoxidation/cyclisation of 7-O-methylluteone.


A hydroxyisoflavone that is orobol in which the hydroxy group at position 3' has been replaced by a methoxy group. It has been isolated from Crotalaria lachnophora.


PIERREIONE B

A methoxyisoflavone that is isoflavone substituted by a methoxy group at position 3', a 2R,3-dihydroxy-3-methylbutoxyl group at position 4' and a dimethylpyran ring fused across positions 6 and 7. Isolated from Antheroporum pierrei, it exhibits antineoplastic activity.


isoflavans

Any isoflavonoid with a 3,4-dihydro-3-aryl-2H-1-benzopyran skeleton and its substituted derivatives.


isoderrone

A  hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 5 and 7 and a 6,6-dimethyl-3,6-dihydro-2H-pyran across positions 3' and 4' respectively. It has been isolated from Ficus mucuso.


NEOBAVAISOFLAVONE

A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone with an additonal hydroxy group at position 4' and a prenyl group at position 3'. Isolated from seeds of Psoralea corylifolia, it exhibits inhibitory activity against DNA polymerase and platelet aggregation.


conferol A

A member of the class of isoflavans that is isoflavan with hydroxy substituents at positions 4, 7 and 4' and a methoxy group at position 2 (the 3R,4S stereoisomer). It is isolated from Caragana conferta and exhibits significant anti-inflammatory activity in the respiratory burst assay.


GLYASPERIN C

A methoxyisoflavan that is (R)-isoflavan substituted by a methoxy group at position 5, hydroxy groups at positions 7, 2' and 4' and a prenyl group at position 6. It has been isolated from Glycyrrhiza uralensis.


A hydroxyisoflavone compound having a hydroxy group at the 7-position.


The (3S)-enantiomer of isoflavanone.


kievitone hydrate

A hydroxyisoflavanone that is isoflavanone substituted by hydroxy groups at positions 5, 7, 2' and 4' and  a 3-hydroxy-3-methylbutyl group at position 8.


A methoxyisoflavan that is the 2'-O-methyl derivative of (-)-phaseollinisoflavan.


A glycosyloxyisoflavone that is biochanin A 7-O-beta-D-glucoside in which the hydroxy group at position 6 of the glucosyl moiety has been acylated by one of the carboxy groups of malonic acid.


BOWDICHIONE

A hydroxyisoflavone with a quinone structure in ring B. Isolated from Dalbergia parviflora, it exhibits antineoplastic and anti-inflammatory activities.


PSEUDOBAPTOGENIN

A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone and in which the phenyl group at position 3 is replaced by a 1,3-benzodioxol-5-yl group.


glyasperin F

A member of the class of  7-hydroxyisoflavones that consists of 2,3,3',4'-tetrahydro-2'H,4H-3,8'-bichromen-4-one substituted by hydroxy groups at positions 5, 5' and 7 and methyl groups at positions 2' and 2'. It has been isolated from Glycyrrhiza uralensis.


The simplest member of the class of 4'methoxyisoflavones that is isoflavone substituted by a methoxy group at position 4'.


isoflavanones

Members of the class of isoflavans that have a 3,4-dihydro-3-aryl-2H-1-benzopyran-4-one skeleton and its substituted derivatives.


biochanin A 7-O-beta-D-glucoside

A glycosyloxyisoflavone that is biochanin A attached to a  beta-D-glucopyranosyl residue at position 7 via glycosidic linkage.


A hydroxyisoflavanone that is isoflavanone substituted by hydroxy groups at positions 2, 6, 7 and 4' respectively.


A member of the class of 4'-methoxyisoflavones that is 4'-methoxyisoflavone that is also substituted by methoxy groups at positions 5, 6, 7.


kwakhurin

A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone with additional hydroxy groups at positions 4' and 6', a methoxy group at position 3' and a prenyl group at position 2'. A characteristic estrogen-like isoflavonoid produced in Pueraria candollei var. mirifica (Leguminosae), which has long been used as a folk medicine for rejuvenation in Thailand.


hydroxyisoflavone

Member of the class of isoflavones bearing at least one hydroxy group.


TECTORIDIN

A glycosyloxyisoflavone that is  tectorigenin substituted by a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage.


(-)-vestitol

A methoxyisoflavan that is  (R)-isoflavan substituted by a methoxy group at position 4' and hydroxy groups at positions 7 and 2' respectively.


XENOGNOSIN B

A member of the class of 4'-methoxyisoflavones that is formononetin with a hydroxy group at the 2'position.


erylatissin B

A member of the class of 7-hydroxyisoflavones that is isoflavone with hydroxy groups at C-7 and C-3' positions and a 2,2-dimethylpyran ring fused to ring B across positions C-4' and C-5'. Isolated from the stem wood of Erythrina latissima, it exhibits antimicrobial and radical scavenging activities.


isoflavan

The simplest member of the class of isoflavans that is chromane substituted by a phenyl substituent at position 3.


dalnigrein

A member of the class of 7-hydroxyisoflavones that is isoflavone having four methoxy substituents at the 2'-, 4'-, 5'- and 6-positions and a hydroxy group at position 7.


A hydroxyisoflavone that is genistein substituted by an additional hydroxy group at position 2'. It has been isolated from Crotalaria lachnophora.


A  methoxyisoflavone that is tectorigenin in which the hydroxy group at position 7 has been replaced by a methoxy group. It has been isolated from Crotalaria lachnophora.


A glycosyloxyisoflavone that is any 7-hydroxyisoflavone compound in which the 7-hydroxy group has been converted into its corresponding O-beta-D-glucoside.


OROBOL

A member of the class of  7-hydroxyisoflavones which consists of isoflavone substituted by hydroxy groups at positions 5, 7, 3' and 4'. It has been isolated from the mycelia of Cordyceps sinensis.


name: regulation of glucocorticoid catabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.


name: regulation of glucocorticoid metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.


name: regulation of cortisol biosynthetic process

description: Any process that modulates the frequency, rate or extent of cortisol biosynthetic process.


name: negative regulation of glucocorticoid biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.


name: positive regulation of glucocorticoid metabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.


name: negative regulation of glucocorticoid metabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.


name: positive regulation of glucocorticoid biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.


name: positive regulation of cortisol biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of cortisol biosynthetic process.


name: negative regulation of glucocorticoid catabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.


name: negative regulation of cortisol biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process.


name: positive regulation of glucocorticoid catabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.


name: regulation of glucocorticoid biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.


A glycosylgalactose consisting of an alpha-D-glucopyranose residue and a D-galactofuranose residue joined in sequence by a (1->2) glycosidic bond


name: zinc finger FYVE domain-containing protein 16 deaminated 2 (human)

description: A zinc finger FYVE domain-containing protein 16 (human) that has been deaminated on the residue at the position equivalent to Gln-1094 of the amino acid sequence represented by UniProtKB:Q7Z3T8-1. Example: UniProtKB:Q7Z3T8-1, Gln-1094, MOD:00685.


LORI_MOUSE Loricrin (sprot)

A loricrin that is encoded in the genome of mouse.


Unresectable Lung Small Cell Carcinoma

description: Lung small cell carcinoma that is not amenable to surgical resection.


fluorescein-5-carbonyl group

A univalent carboacyl group formed from 5-carboxyfluorescein.


isogloboside

An oligoglycosylceramide in which two galactose residues are linked via an alpha-(1->3)-linkage (vs alpha-(1->4) for globosides).


The N-tetracosanoyl derivative of isoglobotriaosyl ceramide.


Any glycotetraosylceramide in which the tetraosyl moiety consists of an N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl group.


N-octanoylisoglobotriaosyl ceramide

The N-octanoyl derivative of isoglobotriaosyl ceramide.


A glycotriaosylceramide having alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl as the glycotriaosyl component.


ISOGLOBOTRIHEXOSYCERAMIDE

The N-hexacosanoyl derivative of isoglobotriaosyl ceramide.


name: Double outlet right ventricle with subaortic ventricular septal defect and pulmonary stenosis

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the aortic origin. There is associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.


methanol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent.


TMOD2_HUMAN Tropomodulin-2 (sprot)

A tropomodulin-2 that is encoded in the genome of human.


tropomodulin-2 isoform 1 (human)

A tropomodulin-2 isoform 1 that is encoded in the genome of human.


tropomodulin-2 isoform h2 (human)

A tropomodulin-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NZR1-2.


ISOXABEN

A benzamide obtained by formal condensation of the carboxy group of 2,6-dimethoxybenzoic acid and the amino group of 3-(3-methylpentan-3-yl)-1,2-oxazol-5-amine.


name: testis anion transporter 1 isoform h3 (human)

description: A testis anion transporter 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96RN1-3.


mating behavior

description: The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.


name: male courtship behavior, veined wing extension

description: The process during courtship where the male insect extends his wings. An example of this process is found in Drosophila melanogaster.


name: negative regulation of female receptivity, post-mating

description: Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating.


name: male courtship behavior, proboscis-mediated licking

description: The process during courtship where the male fly licks the genitalia of a stationary female fly with his proboscis. An example of this is found in Drosophila melanogaster.


name: male courtship behavior, veined wing generated song production

description: The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song.


male courtship behavior

description: The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster.


vulval location

description: Location, by the male, of his partner's vulva when backing along the ventral side of the hermaphrodite during mating. The male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate.


name: male courtship behavior, tapping to detect pheromone

description: The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster.


regulation of female receptivity

description: Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances.


name: positive regulation of female receptivity, post-mating

description: Any process that increases the receptiveness of a female to male advances subsequent to mating.


turning behavior involved in mating

description: The sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail.


female courtship behavior

description: The behavior of a female, for the purpose of attracting a sexual partner.


female mating behavior

description: The specific behavior of a female organism that is associated with reproduction.


name: male courtship behavior, orientation prior to leg tapping and wing vibration

description: The process during courtship, where the male orients towards a potential partner. An example of this is found in Drosophila melanogaster.


male mating behavior

description: The specific behavior of a male organism that is associated with reproduction.


name: male courtship behavior, veined wing vibration

description: The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster.


mating behavior, sex discrimination

description: The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner.


courtship behavior

description: The behavior of an organism for the purpose of attracting sexual partners.


name: regulation of female receptivity, post-mating

description: Any process that modulates the receptiveness of a female to male advances subsequent to mating.


response to hermaphrodite contact

description: The response by the male to a hermaphrodite after initial contact following mate finding. The male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate.


name: positive regulation of female receptivity

description: Any process that activates or increases the receptiveness of a female to male advances.


circadian mating behavior

description: The fluctuation in mating behavior that occurs over an approximately 24 hour cycle.


name: negative regulation of female receptivity

description: Any process that stops, prevents or reduces the receptiveness of a female to male advances.


copulation

description: The act of sexual union between male and female, involving the transfer of sperm.


spicule insertion

description: Insertion of the male copulatory spicules into the hermaphrodite. Spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva.


name: GPAN1_DROME G patch domain and ankyrin repeat-containing protein 1 homolog (sprot)

description: A G patch domain and ankyrin repeat-containing protein 1 that is encoded in the genome of fruit fly.


46 XX gonadal dysgenesis

description: 46,XX gonadal dysgenesis (46,XX GD) is a primary ovarian defect leading to premature ovarian failure (POF) in otherwise normal 46,XX females as a result of failure of the gonads to develop or due to resistance to gonadotrophin stimulation.


undecylprodigiosin

A member of the class of tripyrroles that is 1H-pyrrole substituted by (4'-methoxy-1H,5'H-[2,2'-bipyrrol]-5'-ylidene)methyl and undecyl groups at positions 2 and 5, respectively. It is a pigment produced by Stveptomyces coelicolor.


An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the (omega-1)-hydroxy group of (3R,22R)-3,22-dihydroxytricosanoic acid with ascarylopyranose (the alpha anomer). It is a metabolite of the nematode Caenorhabditis elegans.


Elevated serum 11-deoxycortisol

description: Increased concentration of 11-deoxycortisol in the circulation. 11-deoxycorticosterone, which is also known as simply deoxycorticosterone and 21-hydroxyprogesterone, is a steroid hormore that is produces in the adrenals and is a precursor to aldosterone.


adrenal gland hyperfunction

description: Excess production of adrenal cortex hormones.


Primary hypercortisolism

description: Hypercortisolemia associated with a primary defect of the adrenal gland leading to overproduction of cortisol.


Secondary hypercortisolism

description: Hypercortisolemia associated with a overproduction of ACTH (often from a tumor), leading secondarily to overproduction of cortisol.


name: Elevated circulating 21-deoxycortisol concentration

description: The concentration of 21-deoxycortisol in the blood circulation is above the upper limit of normal.


name: CEACAM1a-2S, signal peptide removed N-glycosylasparagine form (mouse)

description: A CEACAM1a-2S, signal peptide removed form (mouse) that includes at least one N-glycosylasparagine. UniProtKB:P31809-4, 35-278, MOD:00160.


CEACAM1a-2S (mouse)

A carcinoembryonic antigen-related cell adhesion molecule 1 sequence variant CEACAM1a (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3LFS8. This form contains the two copies of the Ig domain and is the version with shorter cytoplasmic tail.


name: CEACAM1a-2S, signal peptide removed form (mouse)

description: A CEACAM1a-2S (mouse) that has had the signal peptide removed. UniProtKB:P31809-4, 35-278.


name: TAD2_SCHPO tRNA-specific adenosine deaminase subunit tad2 (sprot)

description: A tRNA-specific adenosine deaminase 2 that is encoded in the genome of Schizosaccharomyces pombe 972h-.


tRNA-specific adenosine deaminase 2

A protein that is a translation product of the human ADAT2 gene or a 1:1 ortholog thereof.


name: tRNA-specific adenosine deaminase 2 isoform 1

description: A tRNA-specific adenosine deaminase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z6V5-1 or a 1:1 ortholog thereof.


name: ADAT2_DANRE tRNA-specific adenosine deaminase 2 (sprot)

description: A tRNA-specific adenosine deaminase 2 that is encoded in the genome of zebrafish.


name: tRNA-specific adenosine deaminase 2 isoform 2 (zebrafish)

description: A tRNA-specific adenosine deaminase 2 (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5RIV4-2.


name: TAD2_YEAST tRNA-specific adenosine deaminase subunit TAD2 (sprot)

description: A tRNA-specific adenosine deaminase 2 that is encoded in the genome of yeast.


name: ADAT2_MOUSE tRNA-specific adenosine deaminase 2 (sprot)

description: A tRNA-specific adenosine deaminase 2 that is encoded in the genome of mouse.


name: tRNA-specific adenosine deaminase 2 isoform 1 (mouse)

description: A tRNA-specific adenosine deaminase 2 isoform 1 that is encoded in the genome of mouse.


name: tRNA-specific adenosine deaminase 2 isoform h2 (human)

description: A tRNA-specific adenosine deaminase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z6V5-2.


name: ADAT2_HUMAN tRNA-specific adenosine deaminase 2 (sprot)

description: A tRNA-specific adenosine deaminase 2 that is encoded in the genome of human.


name: tRNA-specific adenosine deaminase 2 isoform 1 (human)

description: A tRNA-specific adenosine deaminase 2 isoform 1 that is encoded in the genome of human.


name: tRNA-specific adenosine deaminase 2 isoform 1 (zebrafish)

description: A tRNA-specific adenosine deaminase 2 (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5RIV4-1.


name: TAD2_ARATH tRNA-specific adenosine deaminase TAD2 (sprot)

description: A tRNA-specific adenosine deaminase 2 that is encoded in the genome of Arabidopsis thaliana.


name: FIR1_YEAST Factor interacting with REF2 (sprot)

description: A protein that is a translation product of the FIR1 gene in yeast.


name: NAD(P)H dehydrogenase [quinone] 1 isoform 1 (human)

description: An NAD(P)H dehydrogenase [quinone] 1 isoform 1 that is encoded in the genome of human.


name: NAD(P)H dehydrogenase [quinone] 1 isoform 1 acetylated 1 (human)

description: An NAD(P)H dehydrogenase [quinone] 1 isoform 1 (human) that is N-terminal Met acetylated. UniProtKB:P15559-1, Met-1, MOD:00058.


name: response to granulocyte macrophage colony-stimulating factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.


name: cellular response to granulocyte macrophage colony-stimulating factor stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.


name: LCKB2_ARATH Sphingoid long-chain bases kinase 2, mitochondrial (sprot)

description: A protein that is a translation product of the LCKB2 gene in Arabidopsis thaliana.


dermoid cyst of ovary

description: A cystic teratoma that arises from the ovary. It presents as a cystic mass that contains sebaceous material admixed with hairs. In a minority of cases it is bilateral.


name: zinc finger protein 880 isoform h2 (human)

description: A zinc finger protein 880 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6PDB4-2.


name: dual specificity mitogen-activated protein kinase kinase 5 isoform A (human)

description: A dual specificity mitogen-activated protein kinase kinase 5 isoform 2 that is encoded in the genome of human.


A  dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide substituted by hydroxy groups at positions 10 and 11. It is a metabolite of the drug carbamazepine.


The (10S,11S)-enantiomer of 10,11-trans-dihydroxy-10,11-dihydrocarbamazepine.


The (10R,11R)-enantiomer of 10,11-trans-dihydroxy-10,11-dihydrocarbamazepine.


name: fructose 2,6-bisphosphate metabolic process

description: The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.


name: MOT13_MOUSE Monocarboxylate transporter 13 (sprot)

description: A monocarboxylate transporter 13 that is encoded in the genome of mouse.


name: monocarboxylate transporter 13 isoform 1 (mouse)

description: A monocarboxylate transporter 13 isoform 1 that is encoded in the genome of mouse.


Aplasia of the retina

description: A developmental defect characterized by absence of the retina.


Optic disc hypoplasia

description: Underdevelopment of the optic disc, that is of the optic nerve head, where ganglion cell axons exit the eye to form the optic nerve.


Aplasia/Hypoplasia of the fovea

description: Congenital absence or underdevelopment of the fovea centralis.


Optic nerve aplasia

description: Congenital absence of the optic nerve.


Macular agenesis

description: A congenital defect characterized by lack of development of the macula.


septooptic dysplasia

description: Septooptic dysplasia (SOD) is a clinically heterogeneous disorder characterized by the classical triad of optic nerve hypoplasia, pituitary hormone abnormalities and midline brain defects.


Hypoplasia of the fovea

description: Underdevelopment of the fovea centralis.


Aplasia of the fovea

description: Congenital absence of the fovea.


Macular hypoplasia

description: Underdevelopment of the macula lutea.


(8E,10S)-10-hydroxy-8-octadecenoic acid

A HOME in which the hydroxy group is located at position 10 with the double bond at position 8 (the 8E,10S-isomer).


name: fatty acid CoA ligase Acsl3 deaminated 1 (human)

description: A fatty acid CoA ligase Acsl3 (human) that has been deaminated on the residue at the position equivalent to Asn-444 of the amino acid sequence represented by UniProtKB:O95573. UniProtKB:O95573, Asn-444, MOD:00684.


name: GR64C_DROME Gustatory receptor for sugar taste 64c (sprot)

description: A protein that is a translation product of the Gr64c gene in fruit fly.


Generalized Pustular Psoriasis

description: A genetically heterogenous autoinflammatory condition characterized by sterile non-follicular pustules over wide areas of the body.  It is a rare and severe form of psoriasis, and may result in death if not treated.


psoriasis 14, pustular

description: Any psoriasis in which the cause of the disease is a mutation in the IL36RN gene.


DTML1_DICDI Dictomallein-1 (sprot)

A protein that is a translation product of the dtmlA gene in Dictyostelium discoideum.


CDC73-Related Neoplastic Syndrome

description: A group of autosomal dominant-inherited disorders caused by mutation(s) in the CDC73 gene, encoding parafibromin. These disorders are associated with hyperparathyroidism secondary to parathyroid neoplasms.


Hyperparathyroidism-Jaw Tumor Syndrome

description: An autosomal dominant inherited syndrome characterized by the development of parathyroid adenoma or carcinoma, ossifying fibroma of the mandible and maxilla, renal neoplasms, and renal cysts.


isoscutellarein

A tetrahydroxyflavone that is apigenin with an extra hydroxy group at position 8.


glycophorin-C isoform h3 (human)

A glycophorin-C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04921-3.


GLPC_HUMAN Glycophorin-C (sprot)

A glycophorin-C that is encoded in the genome of human.


name: glycophorin-C isoform Glycophorin-C (human)

description: A glycophorin-C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04921-1.


glycophorin-C O-glycosylated 2 (human)

A glycophorin-C (human) that has been O-glycosylated at the residue equivalent to Ser-42 of the amino acid sequence represented by UniProtKB:P04921-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P04921-1, Ser-42, MOD:00002~GNO:G43417UB.


glycophorin-C O-glycosylated 4 (human)

A glycophorin-C (human) that has been O-glycosylated at the residue equivalent to Thr-31 of the amino acid sequence represented by UniProtKB:P04921-1, in which the glycan composition is represented by GlyTouCan:G57317CE. Example: UniProtKB:P04921-1, Thr-31, MOD:00005~GNO:G57317CE.


glycophorin-C O-glycosylated 6 (human)

A glycophorin-C (human) that has been O-glycosylated at the residue equivalent to Thr-33 of the amino acid sequence represented by UniProtKB:P04921-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P04921-1, Thr-33, MOD:00005~GNO:G43417UB.


name: glycophorin-C isoform Glycophorin-D (human)

description: A glycophorin-C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04921-2.


glycophorin-C O-glycosylated 5 (human)

A glycophorin-C (human) that has been O-glycosylated at the residue equivalent to Thr-31 of the amino acid sequence represented by UniProtKB:P04921-1, in which the glycan composition is represented by GlyTouCan:G73004SD. Example: UniProtKB:P04921-1, Thr-31, MOD:00005~GNO:G73004SD.


glycophorin-C O-glycosylated 1 (human)

A glycophorin-C (human) that has been O-glycosylated at the residue equivalent to Ser-15 of the amino acid sequence represented by UniProtKB:P04921-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P04921-1, Ser-15, MOD:00002~GNO:G43417UB.


glycophorin-C O-glycosylated 3 (human)

A glycophorin-C (human) that has been O-glycosylated at the residue equivalent to Thr-31 of the amino acid sequence represented by UniProtKB:P04921-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P04921-1, Thr-31, MOD:00005~GNO:G53434XO.


Adult Acute Eosinophilic Leukemia

description: An acute eosinophilic leukemia occurring in adults.


description: An abnormal increase in the number of mitochondria per cardiac myocyte.


teeth, supernumerary

description: An extra tooth, erupted or unerupted, resembling or unlike the other teeth in the group to which it belongs. Its presence may cause malposition of adjacent teeth or prevent their eruption.


name: LSG1_RAT Large subunit GTPase 1 homolog (sprot)

description: A large subunit GTPase 1 that is encoded in the genome of rat.


name: GSTM4_RAT Glutathione S-transferase Mu 4 (sprot)

description: A glutathione S-transferase mu 4 that is encoded in the genome of rat.


chromosome 4q21 deletion syndrome

description: The 4q21 microdeletion syndrome is a newly described syndrome associated with facial dysmorphism, progressive growth restriction, severe intellectual deficit and absent or severely delayed speech.


name: Metastatic Ovarian Serous Adenocarcinoma

description: Ovarian serous adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Platinum-Resistant Ovarian High Grade Serous Adenocarcinoma

description: Ovarian high-grade serous adenocarcinoma that progresses between one and six months of completing platinum therapy.


name: Unresectable Ovarian Serous Adenocarcinoma

description: Ovarian serous adenocarcinoma that is not amenable to surgical resection.


name: Unresectable Ovarian High Grade Serous Adenocarcinoma

description: Ovarian high-grade serous adenocarcinoma that is not amenable to surgical resection.


name: high grade serous adenocarcinoma of ovary

description: A rapidly growing serous adenocarcinoma that arises from the ovary. It is characterized by the presence of high grade cytologic features and frequent mitotic figures.


name: Refractory Ovarian Low Grade Serous Adenocarcinoma

description: Ovarian low-grade serous adenocarcinoma that is resistant to treatment.


name: low grade serous adenocarcinoma of ovary

description: A slow-growing serous adenocarcinoma that arises from the ovary.  It usually originates from borderline neoplastic processes or adenofibromas.  It is characterized by the presence of low grade cytologic features and infrequent mitotic figures.


name: Recurrent Ovarian High Grade Serous Adenocarcinoma

description: The reemergence of ovarian high-grade serous adenocarcinoma after a period of remission.


name: Recurrent Ovarian Low Grade Serous Adenocarcinoma

description: The reemergence of ovarian low-grade serous adenocarcinoma after a period of remission.


name: Advanced Ovarian Serous Cystadenocarcinoma

description: Ovarian serous cystadenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Locally Advanced Ovarian Serous Cystadenocarcinoma

description: Ovarian serous cystadenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Advanced Ovarian Serous Adenocarcinoma

description: Ovarian serous adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Ovarian High Grade Serous Adenocarcinoma

description: An ovarian high-grade serous adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Refractory Ovarian High Grade Serous Adenocarcinoma

description: Ovarian high-grade serous adenocarcinoma that is resistant to treatment.


name: Refractory Ovarian Serous Adenocarcinoma

description: Ovarian serous adenocarcinoma that is resistant to treatment.


name: Metastatic Ovarian High Grade Serous Adenocarcinoma

description: Ovarian high-grade serous adenocarcinoma that has spread from its original site of growth to another anatomic site.


Recurrent Ovarian Serous Adenocarcinoma

description: The reemergence of ovarian serous adenocarcinoma after a period of remission.


name: Locally Advanced Ovarian Serous Adenocarcinoma

description: Ovarian serous adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Recurrent Platinum-Resistant Ovarian High Grade Serous Adenocarcinoma

description: The reemergence of platinum-resistant ovarian high-grade serous adenocarcinoma after a period of remission.


name: Metastatic Ovarian Serous Cystadenocarcinoma

description: Ovarian serous cystadenocarcinoma that has spread from the original site of growth to other anatomic sites.


name: Platinum-Refractory Ovarian High Grade Serous Adenocarcinoma

description: Ovarian high-grade serous adenocarcinoma that progresses during platinum therapy or within one month of completing platinum therapy.


name: Recurrent Ovarian Serous Cystadenocarcinoma

description: The reemergence of ovarian serous cystadenocarcinoma after a period of remission.


name: Locally Advanced Unresectable Ovarian High Grade Serous Adenocarcinoma

description: An ovarian high-grade serous adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: carbonyl reductase [NADPH] 1 methylated 1 (human)

description: A carbonyl reductase [NADPH] 1 (human) that has been methylated on the residue at the position equivalent to Cys-150 of the amino acid sequence represented by UniProtKB:P16152-1. Example: UniProtKB:P16152-1, Cys-150, MOD:00660.


hypoalphalipoproteinemia

description: A metabolic disorder characterized by deficiency of high density (alpha) lipoprotein in the blood.


hypobetalipoproteinemia

description: A group of lipoprotein metabolism disorders that are characterized by permanently low levels (below the 5th percentile) of apolipoprotein B and LDL cholesterol.


name: immunoglobulin superfamily member 3 isoform 1 (human)

description: An immunoglobulin superfamily member 3 isoform 1 that is encoded in the genome of human.


name: immunoglobulin superfamily member 3 isoform 1

description: An immunoglobulin superfamily member 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75054-1 or a 1:1 ortholog thereof.


name: immunoglobulin superfamily member 3 isoform 1 (mouse)

description: An immunoglobulin superfamily member 3 isoform 1 that is encoded in the genome of mouse.


name: mitochondrial complex III deficiency nuclear type 8

description: Any mitochondrial complex III deficiency in which the cause of the disease is a mutation in the LYRM7 gene.


name: negative regulation of methane biosynthetic process from methylamine

description: Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from methylamine.


name: OTU6B_MOUSE Deubiquitinase OTUD6B (sprot)

description: A deubiquitinase OTUD6B that is encoded in the genome of mouse.


name: epidermal retinol dehydrogenase 2 isoform 1 (mouse)

description: An epidermal retinol dehydrogenase 2 isoform 1 that is encoded in the genome of mouse.


epidermal retinol dehydrogenase 2

A protein that is a translation product of the human SDR16C5 gene or a 1:1 ortholog thereof.


name: RDHE2_MOUSE Epidermal retinol dehydrogenase 2 (sprot)

description: An epidermal retinol dehydrogenase 2 that is encoded in the genome of mouse.


name: epidermal retinol dehydrogenase 2 isoform 1 (human)

description: An epidermal retinol dehydrogenase 2 isoform 1 that is encoded in the genome of human.


name: epidermal retinol dehydrogenase 2 isoform h2 (human)

description: An epidermal retinol dehydrogenase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N3Y7-2.


name: RDHE2_HUMAN Epidermal retinol dehydrogenase 2 (sprot)

description: An epidermal retinol dehydrogenase 2 that is encoded in the genome of human.


name: epidermal retinol dehydrogenase 2 isoform 1

description: An epidermal retinol dehydrogenase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N3Y7-1 or a 1:1 ortholog thereof.


name: YBPE_SCHPO Uncharacterized oxidoreductase C16H5.14c (sprot)

description: An epidermal retinol dehydrogenase 2 that is encoded in the genome of Schizosaccharomyces pombe 972h-.


name: metastasis-associated protein MTA1 isoform 1 (mouse)

description: A metastasis-associated protein MTA1 isoform 1 that is encoded in the genome of mouse.


name: ribosomal biogenesis protein LAS1L isoform h3 (human)

description: A ribosomal biogenesis protein LAS1L (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4W2-3.


LAS1-like protein

A protein that is a translation product of the human LAS1L gene or a 1:1 ortholog thereof.


name: ribosomal biogenesis protein LAS1L methylated 2 (human)

description: A ribosomal biogenesis protein LAS1L (human) that has been methylated on the residue at the position equivalent to Cys-140 of the amino acid sequence represented by UniProtKB:Q9Y4W2-1. Example: UniProtKB:Q9Y4W2-1, Cys-140, MOD:00660.


name: ribosomal biogenesis protein LAS1L isoform h2 (human)

description: A ribosomal biogenesis protein LAS1L (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4W2-2.


Q8SZY9_DROME LD47413p (trembl)

A LAS1-like protein that is encoded in the genome of fruit fly.


name: LAS1L_HUMAN Ribosomal biogenesis protein LAS1L (sprot)

description: A LAS1-like protein that is encoded in the genome of human.


name: ribosomal biogenesis protein LAS1L isoform h4 (human)

description: A ribosomal biogenesis protein LAS1L (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4W2-4.


name: ribosomal biogenesis protein LAS1L isoform h1 (human)

description: A ribosomal biogenesis protein LAS1L (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4W2-1.


Q75JW2_DICDI Las1-like protein (trembl)

A LAS1-like protein that is encoded in the genome of Dictyostelium discoideum.


name: ribosomal biogenesis protein LAS1L methylated 3 (human)

description: A ribosomal biogenesis protein LAS1L (human) that has been methylated on the residue at the position equivalent to Cys-60 of the amino acid sequence represented by UniProtKB:Q9Y4W2-1. Example: UniProtKB:Q9Y4W2-1, Cys-60, MOD:00660.


name: ribosomal biogenesis protein LAS1L isoform m2 (mouse)

description: A ribosomal biogenesis protein LAS1L (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A2BE28-2.


name: ribosomal biogenesis protein LAS1L deaminated 1 (human)

description: A ribosomal biogenesis protein LAS1L (human) that has been deaminated on the residue at the position equivalent to Gln-380 of the amino acid sequence represented by UniProtKB:Q9Y4W2-1. Example: UniProtKB:Q9Y4W2-1, Gln-380, MOD:00685.


name: ribosomal biogenesis protein LAS1L cysteinylated 1 (human)

description: A ribosomal biogenesis protein LAS1L (human) that has been cysteinylated on the residue at the position equivalent to Cys-60 of the amino acid sequence represented by UniProtKB:Q9Y4W2-1. Example: UniProtKB:Q9Y4W2-1, Cys-60, MOD:00765.


name: ribosomal biogenesis protein LAS1L isoform m1 (mouse)

description: A ribosomal biogenesis protein LAS1L (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A2BE28-1.


name: ribosomal biogenesis protein LAS1L methylated 1 (human)

description: A ribosomal biogenesis protein LAS1L (human) that has been methylated on the residue at the position equivalent to Cys-97 of the amino acid sequence represented by UniProtKB:Q9Y4W2-1. Example: UniProtKB:Q9Y4W2-1, Cys-97, MOD:00660.


name: LAS1L_MOUSE Ribosomal biogenesis protein LAS1L (sprot)

description: A LAS1-like protein that is encoded in the genome of mouse.


name: cysteine-rich secretory protein LCCL domain-containing 2 isoform h4 (human)

description: A cysteine-rich secretory protein LCCL domain-containing 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H0B8-4.


name: PPIB_ECOLI Peptidyl-prolyl cis-trans isomerase B (sprot)

description: A bacterial-type peptidyl-prolyl cis-trans isomerase B that is encoded in the genome of Escherichia coli K-12.


name: ubiquitin thioesterase otulin isoform 1 (mouse)

description: A ubiquitin thioesterase otulin isoform 1 that is encoded in the genome of mouse.


polymyalgia rheumatica

description: A syndrome characterized by pain, stiffness, and tenderness of the proximal muscle groups including the shoulder, pelvic girdle and the neck. There is no muscle atrophy and muscle biopsies do not reveal pathologic changes. Additional signs and symptoms include low grade fever, fatigue and depression.


name: zinc finger protein neuro-d4 isoform r1 (rat)

description: A zinc finger protein neuro-d4 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56163-1.


name: TATA-binding protein-associated factor 172 isoform h1 (human)

description: A TATA-binding protein-associated factor 172 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14981-1.


nateglinide

An N-acyl-D-phenylalanine resulting from the formal condensation of the amino group of D-phenylalanine with the carboxy group of trans-4-isopropylcyclohexanecarboxylic acid. An orally-administered, rapidly-absorbed, short-acting insulinotropic agent, it is used for the treatment of type 2 diabetes mellitus.


name: P2X purinoceptor 7 N-glycosylated 2 (rat)

description: A P2X purinoceptor 7 (rat) that has been N-glycosylated at the residue equivalent to Asn-187 of the amino acid sequence represented by UniProtKB:Q64663-1, in which the glycan composition is represented by GlyTouCan:G41247ZX. Example: UniProtKB:Q64663-1, Asn-187, MOD:00160~GNO:G41247ZX.


P2RX7_RAT P2X purinoceptor 7 (sprot)

A P2X purinoceptor 7 that is encoded in the genome of rat.


name: P2X purinoceptor 7 N-glycosylated 1 (rat)

description: A P2X purinoceptor 7 (rat) that has been N-glycosylated at the residue equivalent to Asn-187 of the amino acid sequence represented by UniProtKB:Q64663-1, in which the glycan composition is represented by GlyTouCan:G31852PQ. Example: UniProtKB:Q64663-1, Asn-187, MOD:00160~GNO:G31852PQ.


name: P2X purinoceptor 7 N-glycosylated 3 (rat)

description: A P2X purinoceptor 7 (rat) that has been N-glycosylated at the residue equivalent to Asn-187 of the amino acid sequence represented by UniProtKB:Q64663-1, in which the glycan composition is represented by GlyTouCan:G62765YT. Example: UniProtKB:Q64663-1, Asn-187, MOD:00160~GNO:G62765YT.


name: P2X purinoceptor 7 N-glycosylated 6 (rat)

description: A P2X purinoceptor 7 (rat) that has been N-glycosylated at the residue equivalent to Asn-213 of the amino acid sequence represented by UniProtKB:Q64663-1, in which the glycan structure is represented by GlyTouCan:G09775CH. Example: UniProtKB:Q64663-1, Asn-213, MOD:00160~GNO:G09775CH.


name: P2X purinoceptor 7 N-glycosylated 7 (rat)

description: A P2X purinoceptor 7 (rat) that has been N-glycosylated at the residue equivalent to Asn-213 of the amino acid sequence represented by UniProtKB:Q64663-1, in which the glycan composition is represented by GlyTouCan:G31852PQ. Example: UniProtKB:Q64663-1, Asn-213, MOD:00160~GNO:G31852PQ.


P2X purinoceptor 7 isoform 1 (rat)

A P2X purinoceptor 7 isoform 1 that is encoded in the genome of rat.


name: P2X purinoceptor 7 N-glycosylated 8 (rat)

description: A P2X purinoceptor 7 (rat) that has been N-glycosylated at the residue equivalent to Asn-213 of the amino acid sequence represented by UniProtKB:Q64663-1, in which the glycan structure is represented by GlyTouCan:G37135JQ. Example: UniProtKB:Q64663-1, Asn-213, MOD:00160~GNO:G37135JQ.


name: P2X purinoceptor 7 N-glycosylated 4 (rat)

description: A P2X purinoceptor 7 (rat) that has been N-glycosylated at the residue equivalent to Asn-187 of the amino acid sequence represented by UniProtKB:Q64663-1, in which the glycan composition is represented by GlyTouCan:G80920RR. Example: UniProtKB:Q64663-1, Asn-187, MOD:00160~GNO:G80920RR.


name: P2X purinoceptor 7 N-glycosylated 5 (rat)

description: A P2X purinoceptor 7 (rat) that has been N-glycosylated at the residue equivalent to Asn-213 of the amino acid sequence represented by UniProtKB:Q64663-1, in which the glycan composition is represented by GlyTouCan:G02815KT. Example: UniProtKB:Q64663-1, Asn-213, MOD:00160~GNO:G02815KT.


name: P2X purinoceptor 7 N-glycosylated 9 (rat)

description: A P2X purinoceptor 7 (rat) that has been N-glycosylated at the residue equivalent to Asn-213 of the amino acid sequence represented by UniProtKB:Q64663-1, in which the glycan structure is represented by GlyTouCan:G55220VL. Example: UniProtKB:Q64663-1, Asn-213, MOD:00160~GNO:G55220VL.


name: THA11_HUMAN THAP domain-containing protein 11 (sprot)

description: A THAP domain-containing protein 11 that is encoded in the genome of human.


name: visual system homeobox 2 isoform 1 (human)

description: A visual system homeobox 2 isoform 1 that is encoded in the genome of human.


name: UQCC3_RAT Ubiquinol-cytochrome-c reductase complex assembly factor 3 (sprot)

description: A ubiquinol-cytochrome-c reductase complex assembly factor 3 that is encoded in the genome of rat.


name: neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform m1 (mouse)

description: A neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BM65-1.


name: skeletal dysplasia with delayed epiphyseal and carpal bone ossification


name: inhibitor of growth protein 4 isoform m4 (mouse)

description: An inhibitor of growth protein 4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C0D7-4.


name: O10AC_HUMAN Olfactory receptor 10AC1 (sprot)

description: An olfactory receptor 10AC1 that is encoded in the genome of human.


name: protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 (human)

description: A protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:O15151-1, Ser-367, MOD:00046|MOD:01148.


protein Mdm4 ubiquitinated form (human)

A protein Mdm4 (human) that includes at least one ubiquitinated lysine. UniProtKB:O15151, MOD:01148.


name: protein Mdm4 phosphorylated and ubiquitinated 1 (human)

description: A protein Mdm4 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-342, Ser-367, and Ser-403 of the amino acid sequence represented by UniProtKB:O15151-1 and that includes at least 1 ubiquitinated lysine. Example: UniProtKB:O15151-1, Ser-342/Ser-367/Ser-403, MOD:00046|MOD:01148.


kappa-casein O-glycosylated 100 (human)

A kappa-casein (human) that has been O-glycosylated at the residue equivalent to Thr-181 of the amino acid sequence represented by UniProtKB:P07498-1, in which the glycan structure is represented by GlyTouCan:G00031MO. Example: UniProtKB:P07498-1, Thr-181, MOD:00005~GNO:G00031MO.


name: ATP-dependent RNA helicase DHX30 isoform 2 (mouse)

description: An ATP-dependent RNA helicase DHX30 isoform 1 that is encoded in the genome of mouse.


name: ATP-dependent RNA helicase DHX30 isoform 1

description: An ATP-dependent RNA helicase DHX30 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7L2E3-1 or a 1:1 ortholog thereof.


name: ATP-dependent RNA helicase DHX30 isoform 1 (human)

description: An ATP-dependent RNA helicase DHX30 isoform 1 that is encoded in the genome of human.


DNA polymerase lambda

A protein that is a translation product of the human POLL gene or a 1:1 ortholog thereof.


name: DPOLL_HUMAN DNA polymerase lambda (sprot)

description: A DNA polymerase lambda that is encoded in the genome of human.


DNA polymerase lambda isoform 1 (rat)

A DNA polymerase lambda isoform 1 that is encoded in the genome of rat.


name: DNA polymerase lambda methylated 1 (human)

description: A DNA polymerase lambda (human) that has been methylated on the residue at the position equivalent to Cys-300 of the amino acid sequence represented by UniProtKB:Q9UGP5-1. Example: UniProtKB:Q9UGP5-1, Cys-300, MOD:00660.


name: DNA polymerase lambda isoform h1 (human)

description: A DNA polymerase lambda (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UGP5-1.


DNA polymerase lambda isoform 1 (mouse)

A DNA polymerase lambda isoform 1 that is encoded in the genome of mouse.


name: DNA polymerase lambda isoform h2 (human)

description: A DNA polymerase lambda (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UGP5-2.


name: DPOLL_MOUSE DNA polymerase lambda (sprot)

description: A DNA polymerase lambda that is encoded in the genome of mouse.


DNA polymerase lambda isoform 1

A DNA polymerase lambda that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QXE2-1 or a 1:1 ortholog thereof.


DPOLL_RAT DNA polymerase lambda (sprot)

A DNA polymerase lambda that is encoded in the genome of rat.


name: tyrosine-protein kinase JAK1 deaminated 4 (human)

description: A tyrosine-protein kinase JAK1 (human) that has been deaminated on the residue at the position equivalent to Gln-565 of the amino acid sequence represented by UniProtKB:P23458. UniProtKB:P23458, Gln-565, MOD:00685.


name: transmembrane protease serine 6 isoform h3 (human)

description: A transmembrane protease serine 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IU80-2.


protein vein isoform 2 (fruit fly)

A protein vein (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q94918-2.


name: vacuolar ATPase assembly integral membrane protein Vma21 isoform 1 (mouse)

description: A vacuolar ATPase assembly integral membrane protein VMA21 isoform 1 that is encoded in the genome of mouse.


name: SYYM_SCHPO Tyrosine--tRNA ligase, mitochondrial (sprot)

description: A tyrosine--tRNA ligase, mitochondrial that is encoded in the genome of Schizosaccharomyces pombe 972h-.


name: GTPase KRas isoform 2A farnesylated 1 (human)

description: A GTPase KRas isoform 2A (human) that has been farnesylated on the residue at the position equivalent to Cys-186 of the amino acid sequence represented by UniProtKB:P01116-1. UniProtKB:P01116-1, Cys-186, MOD:00111.


GTPase KRas farnesylated 1 (human)

A GTPase KRas (human) that has been farnesylated on the residue at the position equivalent to Cys-186 of the amino acid sequence represented by UniProtKB:P01116-1. Example: UniProtKB:P01116-1, Cys-186, MOD:00111.


GTPase KRas isoform 2A (human)

A GTPase KRas isoform 1 that is encoded in the genome of human.


GTPase KRas isoform 2B (human)

A GTPase KRas isoform 2 that is encoded in the genome of human.


GTPase KRas deaminated 1 (human)

A GTPase KRas (human) that has been deaminated on the residue at the position equivalent to Gln-43 of the amino acid sequence represented by UniProtKB:P01116-1. Example: UniProtKB:P01116-1, Gln-43, MOD:00685.


name: GTPase KRas isoform 2B farnesylated 1 (human)

description: A GTPase KRas isoform 2B (human) that has been farnesylated on the residue at the position equivalent to Cys-185 of the amino acid sequence represented by UniProtKB:P01116-2. UniProtKB:P01116-2, Cys-185, MOD:00111.


name: dyslexia-associated protein KIAA0319-like protein O-glycosylated 2 (human)

description: A dyslexia-associated protein KIAA0319-like protein (human) that has been O-glycosylated at the residue equivalent to Thr-235 of the amino acid sequence represented by UniProtKB:Q8IZA0-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:Q8IZA0-1, Thr-235, MOD:00005~GNO:G29068FM.


name: BI2L1_HUMAN BAR/IMD domain-containing adapter protein 2-like 1 (sprot)

description: A brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 that is encoded in the genome of human.


name: erythropoietin N-glycosylated 80 (human)

description: An erythropoietin (human) that has been N-glycosylated at the residue equivalent to Asn-51 of the amino acid sequence represented by UniProtKB:P01588-1, in which the glycan structure is represented by GlyTouCan:G36191CD. Example: UniProtKB:P01588-1, Asn-51, MOD:00160~GNO:G36191CD.


name: putative zinc finger protein 487 deaminated 1 (human)

description: A putative zinc finger protein 487 (human) that has been deaminated on the residue at the position equivalent to Gln-243 of the amino acid sequence represented by UniProtKB:B1APH4-1. Example: UniProtKB:B1APH4-1, Gln-243, MOD:00685.


name: ZN487_HUMAN Putative zinc finger protein 487 (sprot)

description: A putative zinc finger protein 487 that is encoded in the genome of human.


name: mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis

description: Any mesenchymal cell apoptotic process that is involved in mesonephric nephron morphogenesis.