Stage III Esophageal Cancer AJCC v7

description: Stage III includes: For squamous cell carcinoma: IIIA (T1-2, N2, M0, Any G, Tumor location: Any); (T3, N1, M0, Any G, Tumor location: Any); (T4a, N0, M0, Any G, Tumor location: Any); IIIB (T3, N2, M0, Any G, Tumor location: Any); IIIC (T4a, N1-2, M0, Any G, Tumor location: Any); (T4b, Any N, M0, Any G, Tumor location: Any); (Any T, N3, M0, Any G, Tumor location: Any).  For adenocarcinoma: IIIA (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G); IIIB (T3, N2, M0, Any G); IIIC (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Epididymal Papillary Cystadenoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A cystadenoma that arises from the epididymis. It is characterized by the presence of small papillary projections in the inner surface of the cysts. It may be sporadic or associated with von Hippel-Lindau disease.


Advanced Basal Cell Carcinoma

description: Basal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IIB Bone Sarcoma AJCC v7

description: Stage IIB includes: T2, N0, M0, G3, G4.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Pathologic Stage IIA Cutaneous Melanoma AJCC v8

description: Stage IIA includes: (T2b, N0, M0); (T3a, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Acquired Phrenic Nerve Palsy

description: Damage to the phrenic nerve that results in paralysis of the hemidiaphragm and was not present at birth.


name: Circumscribed Meningeal Melanocytic Neoplasm

description: A circumscribed neoplasm that arises from leptomeningeal melanocytes. This category includes meningeal melanocytoma and meningeal melanoma.


Mycosis fungoides (Working Formulation)

description: A peripheral (mature) T-cell lymphoma presenting in the skin with patches/plaques and it is characterized by epidermal and dermal infiltration of small to medium-sized T-cells with cerebriform nuclei.  Patients with limited disease generally have an excellent prognosis.  In the more advanced stages, the prognosis is poor. (WHO, 2001)


First degree uterine prolapse

description: The uterus has descended above the hymen.


Stage III Uterine Corpus Cancer AJCC v6

description: Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Local and/or regional spread as defined below.  T3a: Tumor invades serosa and/or adnexa (direct extension or metastasis) and/or cancer cells in ascites or peritoneal washings.  T3b Vaginal involvement (direct extension or metastasis). N0: No regional lymph node metastasis. N1: Regional lymph node metastasis to pelvic and/or para-aortic nodes.  M0: No distant metastasis. (AJCC 6th ed.)


name: Stage M1 Childhood Ependymoma by Toronto Guidelines v2

description: Tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Human Papillomavirus-Independent Vaginal Squamous Cell Carcinoma

description: Vaginal squamous cell carcinoma not associated with human papillomavirus infection.


Stage IIA Cervical Cancer AJCC v9

description: Stage IIA includes: T2a, N0, M0. T2a: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Post-streptococcal reactive arthritis

description: The occurrence of arthritis after infection with group A streptococcus. It is non-migratory, protracted in course, and poorly responsive to anti-inflammatory agents. (from Textbook of Pediatric Rheumatology, 6th ed. Cassidy, Petty, Laxer, and Lindsley)


name: Refractory Female Reproductive System Carcinoma

description: Female reproductive system carcinoma that is resistant to treatment.


name: Low Grade Corneal Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process with low-grade dysplastic features involving the corneal epithelium.


name: Intraductal papillary neoplasm with high grade intraepithelial neoplasia

description: An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts. It is characterized by the presence of severe epithelial atypia.


Nuclear Cataract Grade 3

description: A stage of nuclear sclerotic cataract marked by pronounced yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


name: Platinum-Sensitive Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that has a documented response to platinum-based chemotherapy.


Gastric mucositis

description: An inflammatory process affecting the mucous membrane of the stomach.


name: Stage IVA Cervical Cancer AJCC v6 and v7

description: Stage IVA includes: T4, Any N, M0). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (AJCC 6th and 7th eds.)


Benign neoplasm of lacrimal apparatus

description: A neoplasm that arises from the lacrimal gland or lacrimal drainage system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: FIGO Stage IIC Gestational Trophoblastic Tumor


Hyalinizing Clear Cell Carcinoma

description: A rare, slow-growing carcinoma characterized by the presence of malignant clear and eosinophilic cells in a hyalinized stroma. It has been described in the salivary glands and lung. Most cases are associated with translocation of EWSR1 and ATF1, resulting in the formation of EWSR1-ATF1 fusion gene. The prognosis is good.


Lumbar myelocele

description: Herniation of spinal cord tissue and meninges through a defect in the lumbar region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


name: Metastatic Bladder Clear Cell (Glycogen-Rich) Urothelial Carcinoma

description: Bladder clear cell (glycogen-rich) urothelial carcinoma that has spread to another anatomic site.


name: Myelodysplastic Syndrome, Unclassifiable, with Defining Cytogenetic Abnormality

description: Myelodysplastic syndrome, unclassifiable characterized by persistent cytopenia (s) with 1 percent or fewer blasts in the blood and fewer than 5% in the bone marrow, unequivocal dysplasia in less than 10 percent of the cells in one or more myeloid lineages, and cytogenetic abnormalities considered as presumptive evidence of myelodysplastic syndrome.


Achromic nevus

description: A benign nevus characterized by the absence of melanin pigment in the melanocytes.


Papillary neoplasm

description: A benign, intermediate, or malignant neoplasm characterized by the formation of papillary structures.


name: Childhood Langerhans Cell Histiocytosis without Risk Organ Involvement

description: Langerhans cell histiocytosis that occurs during childhood and does not involve the bone marrow, spleen, liver, or lung.


Esophageal adenocarcinoma stage IV

description: An adenocarcinoma that arises from the esophagus and has metastasized to another anatomic site.


Destructive Arthritis

description: Arthritis associated with the destruction of the cartilage and the articular surface of the bone of the joint. This process severely interferes with movement in the joint.


Lymphoma by Ann Arbor Stage

description: An anatomic stage for Hodgkin and non-Hodgkin lymphomas  based on the Ann Arbor classification criteria.


Bilateral glaucoma

description: Increased pressure in both eyeballs due to obstruction of the outflow of aqueous humor.


Recurrent Childhood Malignant Neoplasm

description: The reemergence of a childhood malignant neoplasm after a period of remission.


name: Locally Advanced Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Intercalated Duct Hyperplasia

description: A salivary ductal proliferation resembling intercalated ducts. (WHO 2017)


Childhood Diabetes Mellitus

description: Diabetes mellitus that develops during childhood.


name: Precursor T-lymphoblastic lymphoma/leukemia recurrent

description: The reemergence of T-lymphoblastic leukemia/lymphoma after a period of remission.


Vaginal Undifferentiated Carcinoma

description: A carcinoma that arises from the vagina and is characterized by the lack of specific cellular differentiation.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 5

description: Dyskeratosis congenita caused by mutation(s) in the RTEL1 gene, encoding regulator of telomere elongation helicase 1.


name: Stage III Gestational Trophoblastic Neoplasm AJCC v8

description: Stage III includes: Any T, M1a. M1a: Gestational trophoblastic neoplasm with lung metastasis. (AJCC 8th Ed.)


name: Pathologic Stage IV Esophageal Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T4a, N2, M0, Any G); (T4b, N0-2, M0, Any G); (Any T, N3, M0, Any G); IVB: (Any T, Any N, M1, Any G). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Cutaneous Mature T-Cell and NK-Cell Neoplasm

description: A group of neoplasms composed of T-lymphocytes with a mature (peripheral/post-thymic) immunophenotypic profile and/or NK-cells affecting the skin.


Refractory Adenocarcinoma

description: An adenocarcinoma that does not respond to treatment.


EBV-Related Hodgkin Lymphoma

description: Hodgkin lymphoma that is caused by Epstein-Barr virus infection.


name: High Grade Pancreatic Intraepithelial Neoplasia

description: A pancreatic epithelial neoplasia characterized by the presence of papillary and rarely flat architectural patterns with formation of cribriform patterns and luminal necrosis.  Severe dysplasia is present.


Neuroendocrine carcinoma of appendix

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the appendix. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Hindgut Neuroendocrine Tumor G3

description: A neuroendocrine tumor grade 3 that arises from the sigmoid colon, descending colon, or rectum.


name: Locally Advanced Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Remote Placental Infarction

description: A focus of necrotic placental parenchyma with marked hyalinization and fibrosis with complete absence of the necrotic chorionic villi, which is frequently more than 7 days of duration.


name: Pathologic Stage IIA Esophageal Adenocarcinoma AJCC v8

description: Stage IIA includes: (T2, N0, M0, G3); (T2, N0, M0, GX). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Stage IIIB Bladder Cancer AJCC v8

description: Stage IIIB includes: T1-T4a, N2, N3, M0. T1: Tumor invades lamina propria (subepithelial connective tissue). T2: Tumor invades muscularis propria. T3: Tumor invades perivesical soft tissue. T4a: Extravesical tumor invades directly into prostatic stroma, uterus, vagina. N2: Multiple regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node metastasis). N3: Lymph node metastasis to the common iliac lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Acquired methemoglobinemia

description: Methemoglobinemia that is caused by exposure to certain drugs (xylocaine and benzene) and nitrate-rich foods.


Stage I Fallopian Tube Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Fallopian tube cancer with tumor limited to fallopian tube(s). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage I Vulvar Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IV Bladder Cancer AJCC v8

description: Stage IV includes: IVA: (T4b, N0, M0); (Any T, Any N, M1a); IVB: (Any T, Any N, M1b). T4b: Extravesical tumor invades pelvic wall, abdominal wall. N0: No regional lymph node metastasis. M0: No distant metastasis. M1a: Distant metastasis limited to lymph nodes beyond the common iliacs. M1b: Non-lymph node distant metastases. (AJCC 8th ed.)


name: Helicobacter Pylori-Related Gastric Adenocarcinoma

description: An adenocarcinoma that arises from the gastric mucosa and is caused by persistent infection with Helicobacter pylori.


name: Locally Advanced Transitional Cell Carcinoma

description: Transitional cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Chemical esophagitis

description: Esophagitis secondary to chemical exposure.


name: Endocrine disorder arising from mental factors

description: An endocrine disorder that is caused by abnormal mental function.


Recurrent Childhood Oligodendroglioma

description: The reemergence of oligodendroglioma in childhood after a period of remission.


Familial Testicular Germ Cell Tumor

description: Germ cell tumor that arises from the testis and is diagnosed in at least two relatives.


name: Stage II Adult Diffuse Small Cleaved Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Congenital hamartoma

description: A hamartomatous lesion which is present at birth.


Immune System and Related Disorders

description: A group of non-neoplastic and neoplastic disorders resulting from the deregulation and/or deficiency of immune system functions. It includes autoimmune disorders (e.g., lupus erythematosus, dermatomyositis, rheumatoid arthritis), congenital and acquired immunodeficiency syndromes including the acquired immune deficiency syndrome (AIDS), and neoplasms (e.g., lymphomas and malignancies secondary to transplantation).


name: Cervical Adenocarcinoma Admixed with Neuroendocrine Carcinoma

description: A carcinoma that arises from the cervix and is characterized by the presence of a cervical adenocarcinoma variant and a neuroendocrine carcinoma component.


Phrenic Nerve Palsy Related to Birth

description: A condition characterized by reduced or absent movement of the ipsilateral diaphragm as a consequence of an injury to the phrenic nerve or its origin in cervical roots 3 through 5 sustained during the birthing process.


name: Metastatic Malignant Neoplasm in the Visual Pathway

description: A malignant neoplasm that has spread to the visual pathway from another anatomic site.


Advanced Ampulla of Vater Carcinoma

description: Carcinoma that arises from the ampulla of Vater and has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IVA Bladder Cancer

description: Stage IV includes T4b, NO,MO/any T NI, MO/ any T N2 MO,/ any T N3 MO/ any T any N M1 : T4b: Tumor invades the pelvic wall, abdominal wall. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. N3: Metastasis in a lymph node more than 5 cm in greatest dimension. M1: Distant metastasis.


name: Moderately Differentiated Malignant Neoplasm

description: A neoplasm whose histologic characteristics are intermediate between poorly differentiated and well differentiated.


Refractory Urothelial Carcinoma

description: Urothelial carcinoma that does not respond to treatment.


Nuclear Cataract Grade 1

description: A stage of nuclear sclerotic cataract marked by mild yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Adult Rhabdomyosarcoma

description: An aggressive malignant mesenchymal neoplasm arising from skeletal muscle in adults.


Paratesticular Endometrioid Tumor

description: A group of very rare tumors with endometrioid epithelial differentiation arising from the paratesticular structures. It includes benign tumors, borderline tumors (tumors with atypical epithelial proliferation), and malignant tumors (endometrioid adenocarcinomas).


name: Stage IVA Gestational Trophoblastic Tumor AJCC v7

description: Stage IVA includes: Any T, M1b, Risk factors: low risk.  M1b: All other distant metastasis.  (AJCC 7th ed.)


Refractory Malignant Glioma

description: Malignant glioma that does not respond to treatment.


name: Childhood Acute Lymphoblastic Leukemia Toronto Guidelines v2, Tier 2

description: A term that refers to the staging of childhood acute lymphoblastic leukemia according to the tier 2 Toronto childhood cancer staging guidelines v2.


Malignant Neoplasm by Grade

description: A term that refers to the categorization of malignant neoplasm by histologic grade.


Stage IIA Cervical Cancer FIGO 2009

description: Cervical carcinoma limited to the upper two-thirds of the vagina. (FIGO 2009)


Toxic polyneuropathy

description: Polyneuropathy that is caused by exposure to toxins.


Vascular implant infection

description: An infectious process originating from an implanted vascular device.


Opisthorchis viverrini Infection

description: An infection caused by the parasite Opisthorchis viverrini. It results from the ingestion of raw or undercooked food. The clinical features vary from mild to severe and include gastrointestinal symptoms, anorexia, weight loss, hepatomegaly, and cholangitis. Patients are at an increased risk of developing cholangiocarcinoma.


name: Recurrent Fallopian Tube Undifferentiated Carcinoma

description: The reemergence of fallopian tube undifferentiated carcinoma after a period of remission.


Conjunctival Lymphangioma

description: A lymphangioma that arises from the conjunctiva.


Castleman Disease, Plasma Cell Type

description: Castleman disease characterized by the presence of prominent hyalinized vessels in the germinal centers and prominent sheets of plasma cells in the interfollicular areas.


name: Vaso-Occlusive Crisis in Sickle Cell-SS Disease

description: Sickle cell-SS disease exacerbated by sudden pain caused by sickled erythrocytes impeding blood flow within a vessel.


CALLA Positive Lymphoblastic Leukemia

description: Acute lymphoblastic leukemia which is positive for the common acute lymphoblastic leukemia antigen.


Gastric Mixed Adenocarcinoma

description: An adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of both glandular and poorly cohesive malignant cellular components.


Liposarcoma non-metastatic

description: Liposarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


Intracranial Plasma Cell Granuloma

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


Non-Neoplastic Disorder

description: Any disorder other than abnormal tissue growth resulting from uncontrolled cell proliferation.


name: Stage II Ampulla of Vater Neuroendocrine Tumor AJCC v8

description: Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor invading through the sphincter of Oddi into duodenal submucosa or muscularis propria, or measuring more than 1 cm. T3: Tumor invading the pancreas or peripancreatic adipose tissue. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Locally Advanced Midgut Neuroendocrine Tumor

description: A midgut neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Lugano Classification Stage II Bulky Childhood Hodgkin Lymphoma AJCC v8

description: Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


Catheter-Related Inflammation

description: Inflammation associated with the use of a catheter.


name: Central Nervous System Vascular Malformations

description: A congenital abnormality of the arteries and veins that is located in the brain or spina cord, and which may increase the risk of bleeding, possibly resulting in impaired mental or physical function.


Spindle cell nodule

description: A benign, reactive lesion occurring status post instrumentation; histologic examination demonstrates a fascicular growth pattern of plump or elongated spindle cells infiltrating the wall of an organ without atypia or necrosis.


name: Recurrent Male Reproductive System Carcinoma

description: The reemergence of a carcinoma that affects the male reproductive system after a period of remission.


name: Locally Advanced Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Childhood Benign Endocrine Neoplasm

description: A childhood epithelial neoplasm that arises from an endocrine organ and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Stage IA2 Cervical Cancer AJCC v8

description: Stage IA2 includes: T1a2, Any N, M0. T1a2: Invasive cervical carcinoma with measured stromal invasion of more than 3.0 mm and not more than 5.0 mm, with a horizontal spread of 7.0 mm or less. M0: No distant metastasis. (AJCC 8th Ed.)


Intracranial Melanoma

description: A melanoma that arises from the leptomeninges within the cranium.


name: Unresectable Primary Malignant Central Nervous System Neoplasm

description: A primary malignant central nervous system neoplasm that is not amenable to surgical resection.


Adnexitis

description: Inflammation of the appendages of the uterus.


name: Metastatic Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma that has spread to other anatomic sites.


Vulvar Cancer by AJCC v7 Stage

description: A term that refers to the staging of vulvar carcinoma according to the American Joint Committee on Cancer, 7th edition.


Genitourinary Cancer

description: A primary or metastatic malignant neoplasm that affects the genitourinary system.


COVID-19-Associated Thromboembolism

description: Thromboembolism caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Hemangioblastic Meningioma

description: An obsolete term referring to hemangiopericytoma of the central nervous system.


Stage IV Gallbladder Cancer AJCC v8

description: Stage IV includes: IVA: T4, N0-1, M0; IVB: (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invading the main portal vein or hepatic artery or invading two or more extrahepatic organs or structures. N0: No regional lymph node metastasis. N1: Metastases to one to three regional lymph nodes. N2: Metastases to four or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Recurrent Neuroendocrine Neoplasm

description: The reemergence of a neuroendocrine neoplasm after a period of remission.


Obesity-Related Malignant Neoplasm

description: A malignant neoplasm that occurs in the context of obesity.


name: Renal Pelvis and Ureter Cancer by AJCC v7 Stage

description: A term that refers to the staging of renal pelvis and ureter cancer according to the American Joint Committee on Cancer, 7th edition.


Adult Acute Basophilic Leukemia

description: An acute basophilic leukemia occurring in adults.


Benign Genitourinary System Neoplasm

description: A neoplasm that arises from the genitourinary system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


X-Linked Dyskeratosis Congenita

description: Dyskeratosis congenita inherited in an X-linked recessive pattern. It is caused by mutations in the DKC1 gene.


Factor I Inactivation

description: Presence of inactivating antibodies to fibrinogen (factor I) in the blood.


Stage I Pancreatic Cancer AJCC v8

description: Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Frotteurism

description: A disorder characterized by recurrent sexual urges, fantasies, or behaviors involving touching the genitals of or rubbing the genitals against a nonconsenting person.


Cyst of Skene's duct

description: A rare benign lesion that arises from the vagina. It is characterized by the presence of squamous epithelial and tubular structures in a fibrovascular stroma.


Renal and perinephric abscess

description: An abscess that is located both in the kidney and across the renal capsule into the perinephric space.


name: Unresectable Fallopian Tube Adenocarcinoma

description: Fallopian tube adenocarcinoma that is not amenable to surgical resection.


name: Recurrent Platinum-Sensitive Fallopian Tube Carcinoma

description: The reemergence of platinum-sensitive fallopian tube carcinoma after a period of remission.


Polycythemia Vera, Polycythemic Phase

description: Polycythemia vera characterized by the proliferation of the erythroid, granulocytic, and megakaryocytic lineages. The peripheral blood shows excess of red blood cells, neutrophilia, and thrombocytosis. The bone marrow is hypercellular for the patient's age.


name: Adenocarcinoma in situ in tubulovillous adenoma

description: A non-invasive adenocarcinoma arising from a tubulovillous adenoma.


Cystic Trophoblastic Tumor

description: A rare trophoblastic neoplasm that arises in metastatic sites of testicular mixed germ cell tumors following chemotherapy, or is part of treated or untreated testicular mixed germ cell tumors, or is secondary to either chemotherapy-induced or spontaneous regression of testicular choriocarcinoma. It has also been described in central nervous system post-chemotherapy primary germ cell tumors. It is characterized by the presence of cysts lined by squamoid trophoblastic cells. The cysts are often compressed surrounded by other germ cell components.


name: Infectious mononucleosis-like post-transplant lymphoproliferative disorder

description: An early post-transplant lymphoproliferative lesion characterized by immunoblastic proliferation and paracortical expansion as seen in infectious mononucleosis.  There is architectural preservation of the involved tissues.  Oligoclonal or monoclonal cellular populations have been detected in a small number of cases.  In some cases, a polymorphic or monomorphic post-transplant lymphoproliferative disorder may follow this early lesion.


Recurrent Myxoid Liposarcoma

description: The reemergence of myxoid liposarcoma after a period of remission.


Sickle Cell Trait

description: An individual who is heterozygous for the mutation that causes sickle cell anemia.


Stage II Gastric Cancer AJCC v6

description: Stage II includes: (T1, N2, M0), (T2a/b, N1, M0), (T3, N0, M0).  T1: Tumor invades lamina propria or submucosa. T2: Tumor invades muscularis propria or submucosa.  T2a: Tumor invades muscularis propria.  T2b: Tumor invades subserosa.  T3: Tumor penetrates serosa (visceral peritoneum) without invasion of adjacent structures. N1: Metastasis in 1 to 6 regional lymph nodes. Metastasis in 7 to 15 regional lymph nodes.  M0: No distant metastasis. (AJCC 6th ed.)


Cystic Oncocytic Neoplasm

description: An oncocytoma with cystic degenerative changes.


Sarcoma by FNCLCC Grade

description: Grading of sarcomas according to the French Federation of Cancer Centers Sarcoma Group (FNCLCC). This sarcoma grading system is based on three factors: differentiation, mitotic count, and tumor necrosis. The scores for each factor are added to determine the grade (1 to 3) for the sarcoma.


Compound nevus

description: A nevus composed of neoplastic melanocytes that infiltrate both the epidermis and the dermis.


name: Hodgkin's disease mixed cellularity stage I supradiaphragmatic


Unresectable Gallbladder Carcinoma

description: A carcinoma that arises from the gallbladder and it is not amenable to surgical resection.


Stage IIIA Cutaneous Melanoma AJCC v7

description: Stage IIIA includes: (T1-4a, N1a, M0); (T1-4a, N2a, M0).  T1-4a: Non-ulcerated cutaneous melanoma of any thickness.  N1a: Cutaneous melanoma with micrometastasis in one regional lymph node.  N2a: Cutaneous melanoma with micrometastases in 2-3 regional lymph nodes.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


name: Sustained Ventricular Arrhythmia Related to COVID-19

description: Ventricular tachycardia or ventricular fibrillation lasting greater than or equal to 30 seconds, or requiring direct current cardioversion (DCCV) in a patient with probable or confirmed acute COVID-19.


name: Breast Columnar Cell Hyperplasia with Atypia

description: A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini.  The acini are lined by more than two layers of columnar epithelial cells.  Cytologic atypia is present.  Prominent apical cytoplasmic snouts and intraluminal secretions are also present.


Resectable Liposarcoma

description: Liposarcoma that is amenable to surgical resection.


Stage IIIC Testicular Cancer AJCC v8

description: Stage IIIC includes: (Any pT/TX, N1-3, M0, S3); (Any pT/TX, Any N, M1a, S3); (Any pT/TX, Any N, M1b, Any S). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. M1a: Testicular cancer with non-retroperitoneal nodal or pulmonary metastases. M1b: Testicular cancer with non-pulmonary visceral metastases. S3: LDH more than 10 x N or hCG (mlU/mL) more than 50,000 or AFP (ng/mL) more than 10,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


name: Recurrent Adult Acute Lymphoblastic Leukemia

description: The reemergence of acute lymphoblastic leukemia in adults after a period of remission.


Biliary Intraepithelial Neoplasia-1

description: Biliary intraepithelial neoplasia characterized by the presence of low grade epithelial atypia.


Refractory Aggressive NK-Cell Leukemia

description: Aggressive NK-cell leukemia that is resistant to treatment.


Factor VIII Inactivation

description: Presence of inactivating antibodies to factor VIII in the blood.


Scrotal Infection

description: A bacterial, fungal or viral infectious process affecting the scrotum.


Tubular adenoma of breast

description: A benign, well circumscribed neoplasm that arises from the breast.  It is composed entirely of tubular structures that contain epithelial and myoepithelial cells.


Stage IVA Gallbladder Cancer AJCC v7

description: Stage IVA includes: T4, N0-1, M0. T4: Tumor invades the main portal vein or hepatic artery, or invades two or more extrahepatic organs or structures.  N0: No regional lymph node metastasis.  N1: Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein. M0: No distant metastasis.  (from AJCC 7th Ed.)


Ocular surface squamous neoplasia

description: An umbrella term that comprises the spectrum of squamous neoplasms of the conjunctiva, ranging  from low-grade squamous intraepithelial neoplasia to invasive conjunctival squamous cell carcinoma.


Urethritis Cystica and Glandularis

description: A reactive inflammatory disorder affecting the urethra.  It is characterized by the development of small cysts in the urethral wall.  The cysts are lined by urothelial cells and metaplastic glandular cells.


name: Intraocular Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that occurs in the intraocular area.


name: Congenital spondylolysis of lumbosacral region

description: A defect in the pars interarticularis of the vertebral arch of a lumbar or sacral vertebra that is present at the time of birth.


Chronic Phase Primary Myelofibrosis

description: Primary myelofibrosis characterized by the presence of less than 10% blasts in the peripheral blood or bone marrow.


Advanced NUT Carcinoma

description: NUT carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Immature Granulocytic Sarcoma

description: A granulocytic sarcoma composed of myeloblasts and promyelocytes (WHO 2001).


Staphylococcal osteomyelitis

description: Osteomyelitis resulting from an infection with Staphylococcus.


Non-Neoplastic Lacrimal System Disorder

description: A non-neoplastic disorder that affects the lacrimal gland and/or the lacrimal drainage system.


Unresectable Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that is not amenable to surgical resection.


Childhood Sarcoma

description: A sarcoma that occurs during childhood.


Locally Advanced Anal Carcinoma

description: Anal carcinoma that has spread to nearby tissues or lymph nodes.


name: Mental disorder due to a general medical condition

description: A category of psychiatric disorders which are the direct physiologic consequence of a general medical condition.


Necrotising vasculopathy

description: Disorders of blood vessels characterized by luminal narrowing due to intramural immune deposits.


Liver Dysplastic Nodule

description: A premalignant neoplastic nodular lesion of the liver that usually measures less than 15 mm.  It is found during microscopic examination of liver tissues, usually in cirrhotic livers.  Based on the degree of atypia, it is classified as low or high grade.


name: Pathologic Stage III Retinoblastoma AJCC v8

description: Stage III includes: Any pT, pN1, cM0, Any H. pN1: Regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


name: Metastatic Platinum-Resistant Fallopian Tube Carcinoma

description: A platinum-resistant fallopian tube carcinoma that has spread from its original site of growth to another anatomic site.


Stage I Uterine Corpus Cancer

description: Stage I includes: I (T1, N0, M0); IA: (T1a, N0, M0); IB (T1b, N0, M0). T1: Tumor confined to corpus uteri. T1a: Tumor limited to the endometrium or invades less than one-half of the myometrium. T1b: Tumor invades one-half or more of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Central Nervous System Dermoid Cyst

description: A dermoid cyst arising in the central nervous system.


Traumatic arthropathy

description: Any arthropathy that is caused by trauma.


name: Locally Advanced Pancreatic Adenocarcinoma

description: A pancreatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Laryngeal Carcinoid Tumor

description: A rare, well differentiated, low grade neuroendocrine neoplasm that arises from the larynx.


Advanced Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Systemic Mastocytosis with an Associated Germ Cell Tumor

description: A disorder characterized by systemic infiltration of internal organs by aggregates of neoplastic mast cells and the presence of a co-occurring germ cell tumor.


name: Stage IV Testicular Non-Seminomatous Germ Cell Tumor


Mesonephric-like adenocarcinoma

description: An exceedingly rare adenocarcinoma that arises from the uterine corpus and ovary and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage.


Adult Acute Megakaryoblastic Leukemia

description: An acute megakaryoblastic leukemia occurring in adults.


Treatment-sensitive HIV Infection

description: An infection with human immunodeficiency virus that responds to therapy.


Acute Myeloid Leukemia with del(20q)

description: Acute myeloid leukemia associated with deletion of the long arm of chromosome 20 [del(20q)].


Deep penetrating nevus

description: A subtype of WNT-activated deep penetrating/plexiform melanocytoma (nevus). It is characterized by a wedge-shaped pattern and extension of the neoplastic melanocytic proliferation into the deep reticular dermis or subcutis.


Ecchordosis physaliphora

description: A very rare, slow growing, usually asymptomatic hamartomatous lesion that arises from ectopic notochordal tissue.  Morphologically it is characterized by the presence of typical physaliphorous cells in a myxoid background.


neoplasm of basal ganglia

description: A benign or malignant neoplasm that affects the basal ganglia.


description: Coagulation disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Cavernous Angioleiomyoma

description: A morphologic variant of angioleiomyoma characterized by the presence of markedly dilated vascular channels.


Peri-prosthetic Joint Infection

description: Infection around an implant following joint replacement.


name: Other Iatrogenic Immunodeficiency-Related Lymphoproliferative Disorders

description: Lymphoid proliferations or lymphomas that arise in patients treated with immunosuppressive drugs for autoimmune diseases or conditions other than in the post-transplant setting. (WHO 2017)


adenocarcinoma of urinary tract

description: A rare carcinoma with pure glandular differentiation arising anywhere in the urinary tract. This group does not include clear cell and endometrioid adenocarcinomas.


name: Metastatic Childhood Ependymoma by Toronto Guidelines v2

description: Disease beyond local site (e.g., other lesions in brain or spine or tumor cells in CSF or distant metastases). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Bacterial gastroenteritis

description: Gastroenteritis resulting from a bacterial infection.


Foregut Neuroendocrine Tumor G3

description: A neuroendocrine tumor grade 3 that arises from the esophagus, stomach, or duodenum.


Gastric Hodgkin's Lymphoma

description: An extremely rare Hodgkin lymphoma that arises from the stomach.


name: Cervical high grade squamous intraepithelial lesion

description: A precancerous neoplastic process that affects the cervical squamous epithelium. It is usually associated with human papillomavirus infection. It is classified as cervical squamous intraepithelial neoplasia 2 when there is nuclear atypia in both the upper and lower epithelial layers, mitotic figures are confined to the basal two-thirds of the epithelium, and maturation is present in the upper half of the epithelium. It is classified as cervical squamous intraepithelial neoplasia 3 when there is nuclear atypia and mitotic figures throughout the entire thickness of the epithelium, and maturation is absent or confined to the upper third of the epithelium.


name: Pathologic Stage II Esophageal Adenocarcinoma AJCC v8

description: Stage II includes: IIA: (T2, N0, M0, G3); (T2, N0, M0, GX); IIB: (T1, N1, M0, Any G); (T3, N0, M0, Any G). T2: Tumor invades the muscularis propria. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. GX: Grade cannot be assessed. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


description: A meningioma that arises within the cranial cavity and results from exposure to radiation.


Astrocytoma, IDH-Wildtype

description: Astrocytoma lacking mutations in IDH1 or IDH2 genes. It includes diffuse astrocytoma, IDH-wildtype and anaplastic astrocytoma, IDH-wildtype.


name: Stage IA Ampulla of Vater Cancer AJCC v7

description: Stage IA includes: T1, N0, M0. T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Locally Advanced Malignant Skin Neoplasm

description: A malignant neoplasm of the skin that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Unresectable Platinum-Resistant Fallopian Tube Carcinoma

description: A platinum-resistant fallopian tube carcinoma that is not amenable to surgical resection.


name: Unresectable Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted

description: Oligodendroglioma, IDH-mutant and 1p/19q-codeleted that is not amenable to surgical resection.


Myolipoma

description: A benign extrauterine tumor composed of mature adipocytes and smooth muscle cells.


name: Stage IIIA Merkel Cell Carcinoma AJCC v7

description: Stage IIIA includes: Any T, N1a, M0.  N1a: Micrometastasis in regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th Ed.)


Vulvar Tubulovillous Adenoma

description: An intestinal-type adenoma that arises from the vulva. It is characterized by the presence of a tubulovillous architectural pattern.


name: FIGO Stage IVB Gestational Trophoblastic Tumor


Benign Thalamic Neoplasm

description: A neoplasm that arises from the thalamus and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Nodular and Massive Retinal Gliosis

description: A spectrum of discrete retinal glial proliferations surrounding blood vessels, ranging in size from small nodules to massive lesions that fill the eye. (WHO 2018)


Conventional Schwannoma

description: A common, usually encapsulated benign nerve sheath tumor composed of well-differentiated Schwann cells.


Borderline Broad Ligament Serous Tumor

description: A rare non-invasive tumor that arises from the broad ligament. It is characterized by the presence of serous epithelial cell proliferation and cytological atypia.


Lymphosarcoma of spleen

description: An antiquated term that refers to a non-Hodgkin lymphoma composed of small and medium sized lymphocytes affecting the spleen.


name: Metastatic Digestive System Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that arises from any part of the digestive system and has metastasized to another anatomic site.


Thrombotic Disorder

description: A disorder in which there is pathological development of blood clots within the cardiovascular system.


name: Primary cutaneous acral CD8 positive T-cell lymphoma

description: A primary cutaneous T-cell lymphoproliferative disorder that presents as an acral (peripheral) lesion. It is composed of CD8-positive neoplastic T-lymphocytes. It is usually localized to a single site and has an indolent clinical course. Local or more extensive recurrences have been described in a minority of patients.


Secondary Glioblastoma

description: A glioblastoma arising from a lower grade astrocytoma.


description: A lymphoproliferative disorder that occurs in a patient with immunodeficiency.


Recurrent Malignant Glioma

description: The reemergence of malignant glioma after a period of remission.


AIDS-Related Hodgkin Lymphoma

description: Hodgkin lymphoma secondary to AIDS. An increased incidence of Hodgkin lymphomas has been observed in HIV positive patients. Most cases are morphologically classified as lymphocyte depleted or mixed cellularity Hodgkin lymphomas.


name: Solar Radiation-Related Malignant Neoplasm

description: A malignant neoplasm arising in an anatomic site exposed to solar radiation.


Basal cell hyperplasia

description: A pathologic hyperplastic process characterized by the proliferation of the cells of the epithelial layer that resemble the basal cells of the lower part of the epidermis.


Childhood Nervous System Neoplasm

description: A neoplasm that affects the nervous system during childhood.


Extra-adrenal paraganglioma, malignant

description: An extra-adrenal paraganglioma that metastasizes to regional or distant anatomic sites.  Common sites of metastasis include the lymph nodes, lungs, bones, and liver.


Adult Myofibroma

description: A rare myofibroma that occurs in adults.


name: Unresectable Abdominal Neuroendocrine Neoplasm

description: An abdominal neuroendocrine neoplasm that is not amenable to surgical resection.


Pelvic Rhabdomyosarcoma

description: Rhabdomyosarcoma involving the organs and structures in the pelvis.


Nodular Melanoma

description: A melanoma that arises from the skin and mucosal sites. It is characterized by a vertical growth phase and lacks a significant radial growth phase. It may or may not arise from a pre-existing nevus. Morphologically, it is characterized by the presence of cohesive aggregates of neoplastic melanocytes in the dermis that often exhibit an epithelioid appearance. The overlying epidermis is often involved.


name: AIDS-Related Lymphoma by Working Formulation


name: Lugano Classification Stage II Bulky Hodgkin Lymphoma AJCC v8

description: Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


Non-Neoplastic Urethra Disorder

description: A non-neoplastic disorder affecting the urethra.


Recurrent Spindle Cell Sarcoma

description: The reemergence of spindle cell sarcoma after a period of remission.


Unresectable Gallbladder Adenocarcinoma

description: Adenocarcinoma that arises from the gallbladder and is not amenable to surgical resection.


name: Recurrent Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

description: The reemergence of acute myeloid leukemia with recurrent genetic abnormalities after a period of remission.


name: Usual Prostate Adenocarcinoma with Neuroendocrine Differentiation

description: Acinar adenocarcinoma of the prostate gland characterized by the presence of scattered neuroendocrine cells by immunohistochemistry.


Benign neoplasm of broad ligament

description: A neoplasm that arises from the broad ligament and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Mature Plasmacytoid Dendritic Cell Proliferation Associated with Myeloid Neoplasm

description: A clonal proliferation of plasmacytoid dendritic cells in patients with defined myeloid neoplasms. It is characterized by neoplastic proliferations of mature cells with plasmacytoid morphology in the skin, bone marrow, and very rarely, lymph nodes. Patients are predominantly older males.


name: Serous Endometrial Intraepithelial Carcinoma

description: A precursor of endometrial serous adenocarcinoma characterized by the replacement of the normal endometrial cells by malignant glandular cells that resemble the malignant cells of invasive serous adenocarcinoma. The endometrial neoplastic process is non-invasive. It may coexist with invasive endometrial adenocarcinoma or can be associated with metastases outside the uterus, in the absence of invasive endometrial carcinoma.


Arrhythmia-Induced Cardiomyopathy

description: A reversible cardiomyopathy presumed to result from the presence of arrhythmias, including the tachycardia-induced cardiomyopathy (T-CM), atrial fibrillation-induced cardiomyopathy (AF-CM), and premature ventricular contraction-induced cardiomyopathy (PVC-CM).


Stage IIA Prostate Cancer AJCC v7

description: Stage IIA includes: (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X). T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  (AJCC 7th ed.)


Blue rubber bleb nevus syndrome

description: A hemangioma present at birth.  It is characterized by the presence of rubbery skin lesions.


name: Refractory Digestive System Neuroendocrine Neoplasm

description: A digestive system neuroendocrine neoplasm that is resistant to treatment.


Severe Sepsis

description: Clinical syndrome defined by the presence of both infection and a systemic inflammatory response that progresses to multi-organ failure.


Thoracoceloschisis

description: A congenital fissure of both the thoracic and abdominal walls.


In situ mantle cell neoplasia

description: A neoplastic lymphoid process characterized by the presence of cyclin D1 positive lymphoid cells, typically in the inner mantle zones of lymphoid tissue follicles, in cases that do not suggest the diagnosis of a mantle cell lymphoma. It is often found incidentally and has a low rate of progression.


name: Clinical Stage IV Esophageal Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Small cell carcinoma, fusiform cell

description: A neuroendocrine carcinoma composed of malignant fusiform small cells.


name: Systemic Hydroa Vacciniforme Lymphoproliferative Disorder

description: Hydroa vacciniforme lymphoproliferative disorder characterized by severe clinical course and associated with fever, lymph node involvement, and involvement of internal organs by EBV-positive T-cells and NK-cells. It usually affects Asian and Latin American individuals.


name: Recurrent Endocervical Adenocarcinoma, Usual-Type

description: The reemergence of endocervical adenocarcinoma, usual-type after a period of remission.


name: Stage III Renal Pelvis and Ureter Cancer AJCC v8

description: Stage III includes: T3, N0, M0. T3: For renal pelvis only: Tumor invades beyond muscularis into peripelvic fat or into the renal parenchyma. For ureter only: Tumor invades beyond muscularis into periureteric fat. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Myeloid Leukemia, Philadelphia- Negative

description: Myeloid leukemia characterized by the absence of Philadelphia chromosome.


name: mucinous cystic neoplasm with moderate dysplasia

description: A non-invasive mucinous cystic neoplasm that arises from the pancreas and is characterized by the presence of moderate dysplasia.  The neoplastic columnar mucin-producing epithelial cells form papillary projections or crypt-like invaginations. There is cellular pseudostratification and mitotic activity present.


Hindgut Neuroendocrine Tumor G1

description: A neuroendocrine tumor that arises from the sigmoid colon, descending colon, or rectum.


Stage IA Osteosarcoma AJCC v7

description: Stage IA includes: T1, N0, M0, G1, G2, GX.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Recurrent Chronic Leukemia

description: The reemergence of chronic leukemia after a period of remission.


Filiform Serrated Adenoma

description: A traditional serrated adenoma characterized by the presence of prominent villous projections of the neoplastic epithelium.


name: Recurrent Acute Panmyelosis with Myelofibrosis

description: The reemergence of acute panmyelosis with myelofibrosis after a period of remission.


Mild epithelial dysplasia

description: A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. It is characterized by the presence of mild epithelial dysplasia.


Neutrophilic dermatosis

description: A type of dermatosis characterized by dense infiltration of neutrophils in the skin without evidence of infection or vasculitis. It may be secondary to an underlying systemic illness.


Non-Neoplastic Cardiovascular Disorder

description: A non-neoplastic disorder that affects the heart and/or vessels.  Representative examples include myocardial infarction, endocarditis, arteriosclerosis, thrombosis, and lymphedema.


name: Locally Advanced Bladder Urothelial Carcinoma

description: A bladder urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


dyskeratosis congenita

description: A rare genetic disorder characterized by nail dystrophy, reticulated skin pigmentation especially on the neck and chest, and oral leukoplakia.  In about half the cases mutations in the TERT, TERC, DKC1, or TINF2 genes are identified.  Patients are at an increased risk of developing bone marrow failure, myelodysplastic syndrome, leukemia, or cancer, especially in the head and neck region.


Chronic acquired lymphedema

description: A condition that is caused by trauma to the lymph system, which disrupts the normal flow of lymph fluid. This is most often due to surgery that requires lymph node removal or a large amount of lymph tissue. This disruption is especially apparent if the lymph nodes under the arm and arm and around the breast are compromised due to breast cancer surgery, diagnostic dissection, mastectomy, or radiation.


name: Acute Myeloid Leukemia with Myelodysplasia-Related Gene Mutations

description: A group of acute myeloid leukemias characterized by the presence of gene mutations that are associated with myelodysplasia.


Stage IV Prostate Cancer AJCC v6

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, Any N, M1) (Any G).  T4: Tumor is fixed or invades adjacent structures other than seminal vesicles: bladder neck, external sphincter, rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 6th ed.)


name: Testicular Sertoli Cell Tumor, Lipid Rich Variant

description: A testicular Sertoli cell tumor in which the neoplastic cells have clear and vacuolated cytoplasm due to accumulation of intracytoplasmic lipids.


Endometrial Dedifferentiated Carcinoma

description: A carcinoma that arises from the endometrium and is characterized by the presence of an undifferentiated carcinomatous component and a second component of either FIGO grade 1 or 2 endometrioid carcinoma.


Adult Type Granulosa Cell Tumor

description: A low-grade malignant sex cord-stromal tumor occurring in the ovary and rarely in the testis. It is composed of granulosa cells in an often fibrothecomatous stroma. The neoplastic cells may form various patterns including the microfollicular, which is characterized by the presence of Call-Exner bodies, macrofollicular, insular, trabecular, and diffuse pattern. In females, it affects middle aged to post-menopausal women. Signs and symptoms include abdominal mass, hemoperitoneum, and ascites. Estrogenic and rarely androgenic manifestations may be present. The vast majority of cases present as stage I tumors; however, all tumors have a potential for aggressive clinical course. In males, it is reported in the age range of 16-76 years and the average age at presentation is 44 years. A minority of patients have gynecomastia. Metastases have been reported in a minority of patients.


Stage IA2 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 3 mm and not more than 5 mm in depth. (FIGO 2009)


A1 Hydronephrosis

description: Antenatal hydronephrosis with the following clinical findings: 1) an anterior-posterior renal pelvis diameter (APRPD) of 4 to less than 7 mm at less than 28 weeks, 2) to less than10 mm at greater than or equal to 28 weeks, and 3) may have central calyceal dilation. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


name: Childhood Benign Genitourinary System Neoplasm

description: A childhood neoplasm that arises from any part of the genitourinary system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Invasive Lipid-Rich Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by the presence of lipid laden tumor cells.


Sickle Cell-SS Disease

description: A variant of sickle cell disease due to homozygosity of the E6V mutation, amino acid substitution of valine for glutamic acid in the sixth position of the beta chain, resulting in the production of hemoglobin S from both alleles.


Steroid-induced myopathy

description: A non-neoplastic disorder affecting the skeletal muscles. It is caused by damage to muscle fibers either by excessive intake of corticosteroids (steroid treatment) or high levels of endogenous corticosteroids due to hormonal abnormalities. Patients usually present with weakness mainly in the proximal muscles of the upper and lower extremities and the neck flexors.


Neonatal Early-Onset Sepsis

description: An infectious disorder of newborn infants that is characterized by a systemic inflammatory response within 72 hours of life and is most commonly caused by bacteria.


Rheumatic aortic valve disease

description: A disorder of the aortic valve secondary to rheumatic fever.


Refractory Cervical Carcinoma

description: Cervical carcinoma that is resistant to treatment.


name: Intrahepatic Bile Duct Biliary Intraepithelial Neoplasia

description: A neoplastic, non-invasive lesion that affects the intrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


46,XY Sex Reversal 2

description: Sex reversal in an individual with 46,XY karyotype caused by point mutations or deletions in the NR0B1 gene, encoding nuclear receptor subfamily 0 group B member 1.


name: Idiopathic 46,XY Differences of Sex Development

description: Conditions affecting individuals whose karyotype is 46,XY that is characterized by atypical development of the internal or external sex structures, or the gonads, and in whom no genetic, environmental, or biochemical causation can be established.


name: Stage IIB Ampulla of Vater Cancer AJCC v7

description: Stage IIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  T2: Tumor invades the duodenal wall.  T3: Tumor invades the pancreas.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Islet Glucagon Cell Hyperplasia

description: Hyperplasia of the alpha cells of the pancreas.


Malignant neoplasm of urethra local

description: A urethral carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Unresectable Pancreatic Neuroendocrine Carcinoma

description: Pancreatic neuroendocrine carcinoma that is not amenable to surgical resection.


Mucosal Melanoma of the Urinary System

description: A malignant melanocytic neoplasm that arises from a mucosal site of the urinary system.


Exogenous Obesity

description: Obesity caused by caloric intake greater than caloric expenditures.


Biventricular congestive heart failure

description: Heart failure due to dysfunction of both the left and right ventricles.


name: Recurrent Extracranial Malignant Solid Neoplasm

description: The reemergence of an extracranial malignant solid neoplasm after a period of remission.


name: Aleukemic Acute Lymphoblastic Leukemia Cutis

description: Aleukemic acute lymphoblastic leukemia that manifests with cutaneous involvement.


HPV16 Infection

description: An infection caused by human papillomavirus 16. HPV16 infection is associated with a risk for cervical cancer.


Hemangioma of conjunctiva

description: A hemangioma that arises from the conjunctiva.


Refractory Gallbladder Carcinoma

description: Gallbladder carcinoma that is resistant to treatment.


Ileal Fistula

description: An abnormal communication between the ileum and another organ or cavity.


Vulvar Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the vulva. Representative examples include infection and fibroepithelial polyp.


External hydrocephalus

description: Abnormal increase of cerebrospinal fluid in the subdural space of the brain.


description: A Hodgkin lymphoma that develops in patients who are immunosuppressed with methotrexate.


name: Advanced Extrapulmonary Neuroendocrine Carcinoma

description: Extrapulmonary neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Adult Diffuse Mixed Cell Lymphoma

description: A B-or T-cell non-Hodgkin lymphoma composed of a mixed-sized lymphocytic population occurring in adults.


name: Esophageal Large Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus.  It is characterized by the presence of malignant large cells.


Recurrent Subsequent Malignant Neoplasm

description: The reemergence of a malignant neoplasm other than the original one, after a period of remission.


name: Stage IVA Esophageal Squamous Cell Carcinoma


Eye Melanocytoma

description: A benign neoplastic melanocytic proliferation affecting the optic disk and optic nerve or the uvea.


tubular adenoma of gallbladder

description: An adenoma that arises from the gallbladder.  It is characterized by the presence of a tubular growth pattern.


name: Human Papillomavirus-Related Cervical Carcinoma

description: A carcinoma that arises from the cervix and is caused by human papillomavirus infection.


Stage IV Uterine Corpus Cancer AJCC v6

description: Stage IV includes: IVA: (T4, Any N, M0); IVB: (Any T, Any N, M1).  T4: Tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4).  M1: Distant metastasis (includes metastasis to abdominal lymph nodes other than para-aortic, and/or inguinal lymph nodes: excludes metastasis to vagina, pelvic serosa, or adnexa). (AJCC 6th ed.)


Oligometastatic Gastric Adenocarcinoma

description: Gastric adenocarcinoma that has metastasized to a limited number of sites.


Stage IB Vulvar Carcinoma AJCC v6

description: Stage IB includes: T1b, N0, M0.  T1ab Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension, and with stromal invasion greater than 1mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


name: Appendix Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of an appendiceal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to appendiceal NETs (carcinoid tumors) (NET G1 and G2, and rare well-differentiated G3). High-grade neuroendocrine carcinomas (NEC), goblet cell carcinoids, mixed adenocarcinomas, and adenocarcinomas of the appendix are not staged using this staging system. (from AJCC 8th Ed.)


Breast Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm arising from the breast.


MGMT-Methylated Glioblastoma

description: A glioblastoma characterized by the presence of DNA methylation in the promoter region of the MGMT gene. It is associated with improved survival.


Stage III Skin Cancer

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor with invasion of maxilla, mandible, orbit, or temporal bone.  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th Ed.)


Mental Retardation, X-linked 21/34

description: An X-linked recessive condition caused by mutation(s) in the IL1RAPL1 gene, encoding interleukin-1 receptor accessory protein-like 1. It is characterized by intellectual disability ranging from moderate mental retardation to high-functioning autism.


name: Endometrial Endometrioid Adenocarcinoma with a Poorly Differentiated Carcinomatous Component

description: A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of a component with poorly differentiated carcinoma cells.


Stage I Gallbladder Cancer AJCC v6

description: Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0). T1: Tumor invades lamina propria or muscle layer.  T1a: Tumor invades lamina propria.  T1b: Tumor invades muscle layer.  N0: No regional metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Stage IV Childhood Large Cell Lymphoma

description: Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ)


name: Recurrent Fallopian Tube Transitional Cell Carcinoma

description: The reemergence of fallopian tube transitional cell carcinoma after a period of remission.


name: Stage IIIB Cervical Cancer AJCC v6 and v7

description: Stage IIIB includes: (T3b, Any N, M0); (T1-3, N1, M0).  T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non-functioning kidney. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Malignant melanoma, regressing

description: A skin lesion characterized by the disappearance of the melanoma cells from the primary melanoma site. The disappearance of the malignant cells is associated with fibroplasia of the papillary dermis. According to some authors, complete regression of the primary melanoma may occur in 4-8% of patients.


Foreign body embolism

description: Occlusion of a lumen by a foreign object.


Lentigo simplex

description: The most common form of the skin disorder lentigo, characterized by a single or multiple benign, pigmented macules of unknown etiology that are present at birth or develop in early childhood.


name: Hodgkin's disease nodular sclerosis stage II subdiaphragmatic


name: Stage 0 Cutaneous Melanoma AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Melanoma in situ.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


Refractory Myeloid Neoplasm

description: A myeloid neoplasm that does not respond to treatment.


Stage IV Bladder Cancer AJCC v6

description: Stage IV includes the following: T4b, N0, M0; Any T, N1, M0; Any T, N2 M0; Any T, N3 M0; Any T, Any N, M1.  T4b: Tumor invades the pelvic wall, abdominal wall.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension.  M1: Distant metastasis.  (AJCC 6th Ed.)


Intestinal nematode infection

description: An infection in the gastrointestinal tract by a nematode.


Stage IIA Anal Cancer AJCC v8

description: Stage IIA includes: T2, N0, M0. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Treatment related secondary malignancy

description: The development of a malignant neoplasm in response to medical or surgical treatment, induced by the treatment itself.


name: Anal Extramucosal (Perianal) Adenocarcinoma

description: An anal adenocarcinoma arising from the lining of an anorectal fistulous tract or the anal glands.  The overlying anal mucosa does not show evidence of neoplastic changes.  It usually presents as a submucosal tumor.


Trichogerminoma

description: A rare subtype of trichoblastoma characterized by the presence of lobules of basaloid cells. The lobules are separated by fibrous stroma. It is associated with the expression of recurrent FOXK1/GRHL and GPS2/GRHL gene fusions.


name: Childhood Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A

description: An acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A occurring in children.


name: Stage IV Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Diffuse or disseminated (multifocal) involvement of one or more extra-lymphatic organs with or without associated lymph node involvement or isolated (non-contiguous) extra-lymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s) or any involvement of liver, bone marrow, lungs (except by direct extension from another site) or CSF. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Locally Advanced Neuroendocrine Tumor

description: A neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Tracheal Mucositis

description: An inflammatory process affecting the mucous membrane of the trachea.


name: Lugano Classification Stage II Bulky Adult Hodgkin Lymphoma AJCC v8

description: Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


name: Acute Myeloid Leukemia with a Variant MECOM Rearrangement

description: A term referring to acute myeloid leukemias with rearrangement of the MECOM gene with various genes other than the GATA2 gene.


Cystic Periventricular Leukomalacia

description: Necrosis and softening of the white matter around the ventricles in the brain associated with cystic changes.


Hamartoma of Mature Cardiac Myocytes

description: A non-malignant, focal growth in the heart, composed of unencapsulated nodules of enlarged, hypertrophic, mature cardiac myocytes with a variable amount of collagen and fat.


Prosoposchisis

description: A congenital anatomic defect characterised by a facial cleft that extends from the mouth to the orbit of the eye.


name: Advanced Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that has spread extensively from its original site of growth to other anatomic sites or is no longer responding to treatment.


Disorder of soft tissue

description: A non-neoplastic or neoplastic disorder that affects the soft tissue.


Sporadic Retinoblastoma

description: A retinoblastoma that occurs in a patient without a family history of the disease.


name: Malignant Non-Hodgkin's Lymphoma, Diffuse, Lymphocytic, Poorly Differentiated


Recurrent Acute Leukemia

description: The reemergence of acute leukemia after a period of remission.


Locally Advanced Angiosarcoma

description: An angiosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Intracystic papillary neoplasm with low grade intraepithelial neoplasia

description: An intracholecystic papillary neoplasm that arises from the epithelium of the gallbladder. It is characterized by the presence of mild epithelial atypia.


name: Stage I Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Tumor is limited to the kidney and completely excised. Renal capsule intact, not penetrated by tumor. No tumor invasion of veins or lymphatics of renal sinus. No nodal or hematogenous metastases. No prior biopsy. Negative margins. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Ossification of Anterior Longitudinal Ligament

description: A disorder characterized by benign depositions of calcium in the anterior longitudinal ligament. This condition is usually asymptomatic, but may be associated with dyspnea, dysphagia, spinal cord compression, and peripheral nerve entrapment.


Recurrent Myeloid Neoplasm

description: The reemergence of a myeloid neoplasm after a period of remission.


Pansclerotic Morphea

description: A rare, aggressive form of morphea characterized by sclerosis of the dermis, fascia, and muscle over large parts of the body, resulting in contractures and immobility.


Endocrine Therapy-Induced Alopecia

description: Alopecia caused by treatment with endocrine therapy agents.


name: Transplant-Related Skin Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the skin in a patient with a history of organ transplantation.


name: Female Non-Neoplastic Reproductive System Disorder

description: A non-neoplastic disorder that affects the female reproductive system. Representative examples include endometriosis, pelvic inflammatory disease, and endometritis.


Neonatal Late-Onset Sepsis

description: An infectious disorder of newborn infants that is characterized by a systemic inflammatory response beyond 72 hours of life and is most commonly caused by bacteria.


Recurrent Pancreatic Cystadenocarcinoma

description: The reemergence of pancreatic cystadenocarcinoma after a period of remission.


lipoma of bone

description: A benign neoplasm which is composed of adipocytes and arises from the surface of the bone or the medullary cavity.


Extrapulmonary Neuroendocrine Carcinoma

description: A small or large cell neuroendocrine carcinoma that arises from an anatomic site other than the lung.


Prostate Myeloid Sarcoma

description: Myeloid sarcoma that affects the prostate gland.  It may present in association with or as a site of relapse of acute myeloid leukemia.  Cases of myeloid sarcoma of the prostate gland preceding acute myeloid leukemia have also been reported.


name: Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm

description: Blastic plasmacytoid dendritic cell neoplasm that is resistant to treatment.


Non-Neoplastic Sternal Disorder

description: A non-neoplastic disorder that affects the sternum.


Locally Advanced Gastric Carcinoma

description: A gastric carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Vulvar Melanocytic Neoplasm

description: A neoplasm that originates from melanocytes and arises from the vulva. This category includes congenital and acquired melanocytic nevus, blue nevus, dysplastic melanocytic nevus, atypical melanocytic nevus of genital type, and melanoma.


Cocaine dependence, continuous

description: Physical or psychological dependence on the drug cocaine which is associated with a pattern of continuous use.


Recurrent Adult Hodgkin Lymphoma

description: The reemergence of Hodgkin lymphoma in adulthood after a period of remission.


Classical Poroma

description: A poroma characterized by the presence of cords and aggregates of neoplastic cells in the superficial dermis in connection with the epidermis.


Environment-Related Malignant Neoplasm

description: Cancers caused by exposure to carcinogens in the general environment


Incidental Gallbladder Carcinoma

description: Gallbladder carcinoma that is discovered incidental to gallbladder surgery for another indication.


Advanced Esophageal Carcinoma

description: Esophageal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage II Prostate Cancer AJCC v8

description: Stage II includes: IIA: (cT1a-c, cT2a, N0, M0, PSA equal or more than 10 and less than 20, Grade Group 1); (cT2b-c, N0, M0, PSA less than 20, Grade Group 1); IIB: T1-2, N0, M0, PSA less than 20, Grade Group 2; IIC: (T1-2, N0, M0, PSA less than 20, Grade Group 3); (T1-2, N0, M0, PSA less than 20, Grade Group 4). cT1a: Prostate cancer in which the tumor is an incidental histologic finding in 5% or less of tissue resected. cT1b: Prostate cancer in which the tumor is an incidental histologic finding in more than 5% of tissue resected. cT1c: Prostate cancer in which the tumor is identified by needle biopsy found in one or both sides, but not palpable. cT2a: Prostate cancer in which the tumor involves one-half of one side or less. cT2b: Prostate cancer in which the tumor involves more than one-half of one side but not both sides. cT2c: Prostate cancer in which the tumor involves both sides. T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


name: Childhood Retinoblastoma by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood retinoblastoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


Childhood Liver Neoplasm

description: A benign or malignant neoplasm that affects the liver and occurs during childhood.


Mucosal Nevus

description: A nevus that arises from a mucosal site.


name: Metastatic Bladder Large Cell Neuroendocrine Carcinoma

description: Bladder large cell neuroendocrine carcinoma that has spread to another anatomical site.


name: Primary Cutaneous Diffuse Large B-Cell Lymphoma, Other

description: A rare type of primary cutaneous diffuse large B-cell lymphoma that does not belong in the group of primary cutaneous diffuse large B-cell lymphomas, leg type, or the group of primary cutaneous follicle center lymphomas.  It includes subtypes/entities of diffuse large B-cell lymphoma (e.g. intravascular large B-cell lymphoma, plasmablastic lymphoma, T-cell/histiocyte rich lymphoma) that can involve the skin as the primary anatomic site.  Such cases, unlike their nodal counterparts, usually have an excellent prognosis.


Metastatic ocular melanoma

description: Ocular melanoma that has spread from its original site of growth to another anatomic site.


Cortical Cataract Grade 4

description: A stage of cortical cataract characterized by greater than 90% of the intrapupillary space obscured by opacity. (Modified LOCS II)


name: Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8

description: Stage IIA includes: T1, N1, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Low Grade Biliary Intraepithelial Neoplasia

description: Biliary intraepithelial neoplasia characterized by the presence of low grade epithelial dysplasia.


Gallbladder Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the gallbladder. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


name: H-type congenital tracheoesophageal fistula

description: Congenital tracheoesophageal fistula without esophageal atresia.


Testicular Typical Seminoma

description: A testicular seminoma characterized by the presence of uniform round germ cells with glycogen-rich cytoplasm and large nuclei, and a lymphocytic infiltrate.


name: Non-Neoplastic Connective and Soft Tissue Disorder

description: A non-neoplastic disorder that affects the connective and soft tissue.


Neoplasm by Morphology

description: A classification system grouping neoplasms according to their cellular characteristics.


name: Recurrent Platinum-Resistant Fallopian Tube High Grade Serous Adenocarcinoma

description: The reemergence of platinum-resistant fallopian tube high-grade serous adenocarcinoma after a period of remission.


Short Stature Homeobox Deficiency

description: A rare genetic deficiency characterized by mutations in the SHOX gene and reduced expression or function of the SHOX protein. It results in the disruption of normal bone development and growth starting before birth. It manifests with skeletal abnormalities and short stature.


Eiken Type Chondrodysplasia

description: An autosomal recessive skeletal dysplasia caused by mutation(s) in the PTH1R gene, encoding parathyroid hormone/parathyroid hormone-related peptide receptor. This condition is characterized by severely delayed skeletal maturation, as well as by abnormal modeling of the bones in the hands and feet, abnormal persistence of cartilage in the pelvis, and mild growth retardation. Calcium and phosphate concentrations are normal.


Bladder cancer stage IV

description: A carcinoma that arises from the bladder and has metastasized to another anatomic site.


name: High Grade Mucinous Carcinoma Peritonei with Signet Ring Cells

description: A high-grade mucinous adenocarcinoma that has spread to the peritoneum and is characterized by the presence of signet ring malignant cells.


Bladder Melanoma

description: A rare melanoma that arises from the bladder mucosa.


Extranodal Lymphoma

description: A non-Hodgkin or Hodgkin lymphoma that arises from an anatomic site other than a lymph node.


Non-Neoplastic Bladder Disorder

description: A non-neoplastic disorder that affects the urinary bladder. Representative examples include cystitis, cystolithiasis, and urinary bladder rupture.


Stage IIIB Appendix Carcinoma AJCC v8

description: Stage IIIB includes: (T3, N1, M0); (T4, N1, M0). T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4: Tumor invades the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or mesoappendix, and/or directly invades adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. M0: No distant metastasis. (AJCC 8th ed.)


name: Ampulla of Vater Intestinal-Type Adenocarcinoma

description: An invasive adenocarcinoma arising from the ampulla of Vater. Morphologically, it is characterized by the presence of intestinal-type malignant epithelial cells.


name: Refractory T/NK-Cell Lymphoproliferative Disorder

description: T/NK-cell lymphoproliferative disorder that is resistant to treatment.


Acute Myeloid Leukemia with STAT3-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of STAT3-RARA fusion protein.


Diffuse hyperplasia

description: Hyperplasia characterized by the presence of a diffuse cellular infiltrate.


carcinoma of urinary tract

description: A carcinoma that arises from the organs that comprise the urinary tract. This category includes renal pelvis carcinoma, ureter carcinoma, bladder carcinoma, urethral carcinoma, urothelial carcinoma, adenocarcinoma of the urinary tract, clear cell adenocarcinoma of the urinary tract, diverticular carcinoma of the urinary tract, endometrioid adenocarcinoma of the urinary tract, and squamous cell carcinoma of the urinary tract.


Squamous cell carcinoma, microinvasive

description: A squamous cell carcinoma with minimal stromal invasion.


name: Childhood Retinoblastoma by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood retinoblastoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


name: Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage III includes: (T2, N1, M0); (T3, N0-1, M0); (T4a, N0-1, M0). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IIIA includes: T0-2, N1, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Autosomal Dominant Disorder

description: An inherited disorder that manifests when one copy of a mutated gene is present.


Enteropathic arthritis

description: A form of chronic arthritis that is found in some patients with inflammatory bowel disease.


Cervical Cancer by FIGO Stage 2018

description: A term that refers to the staging of cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging, 2018.


AIDS-Related Malignant Anal Neoplasm

description: A malignant neoplasm arising from the anus and occurring in HIV-positive patients.  Representative examples include squamous cell carcinoma and non-Hodgkin lymphoma.  Homosexual HIV-positive men have an increased risk of developing such malignancies in comparison to the general male population.


Refractory Malignant Endocrine Neoplasm

description: Malignant endocrine neoplasm that is resistant to treatment.


Nutritional Rickets

description: Rickets due to dietary deficiency of calcium, phosphate, or vitamin D.


name: Refractory Post-Essential Thrombocythemia Myelofibrosis

description: Post-essential thrombocythemia myelofibrosis that is resistant to treatment.


Adenocarcinoma with metaplasia

description: An adenocarcinoma characterized by the presence of metaplasia.


Testis cancer recurrent

description: Malignant testicular germ cell tumor reemerging after a period of remission.


name: Low Grade Cervical Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic process that affects the cervical squamous epithelium without evidence of invasion. It is usually associated with human papillomavirus infection. It is characterized by the presence of mild atypia in the superficial epithelial layer that may be associated with koilocytosis. Maturation is present in the upper two thirds of the epithelium. Mitotic figures are not numerous and are present in the basal third of the epithelium.


Cyclitis

description: Inflammation of the ciliary body.


Pseudoangiomatous stromal hyperplasia

description: A benign proliferation of the stromal cells in the breast.  It is classified as simple, when associated with the presence of slit-like spaces without erythrocytes and as fascicular/proliferative, when spindle cell proliferation without atypia is present.  It is often seen in breast tissue specimens as small foci associated with benign epithelial lesions.  Pseudoangiomatous stromal hyperplasia presenting as a well-circumscribed palpable mass is rare.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 1

description: Dyskeratosis congenita caused by autosomal recessive mutation(s) in the NOP10 gene, encoding H/ACA ribonucleoprotein complex subunit 3.


Unresectable Malignant Solid Neoplasm

description: A malignant solid neoplasm that is not amenable to surgical resection.


Bladder Neuroendocrine Tumor

description: A well-differentiated neuroendocrine neoplasm arising from the bladder. It is characterized by the presence of uniform cells with stippled chromatin and inconspicuous nucleoli. Mitotic activity is low and tumor necrosis is absent.


Stage I Prostate Cancer AJCC v8

description: Stage I includes: (cT1a-c, cT2a, N0, M0, PSA less than 10, Grade Group 1); (pT2, N0, M0, PSA less than 10, Grade Group 1). cT1a: Prostate cancer in which the tumor is an incidental histologic finding in 5% or less of tissue resected. cT1b: Prostate cancer in which the tumor is an incidental histologic finding in more than 5% of tissue resected. cT1c: Prostate cancer in which the tumor is identified by needle biopsy found in one or both sides, but not palpable. cT2a: Prostate cancer in which the tumor involves one-half of one side or less. pT2: Prostate cancer which is organ confined. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. (AJCC 8th ed.)


name: Unresectable Gastroesophageal Junction Adenocarcinoma

description: Gastroesophageal junction adenocarcinoma that is not amenable to surgical resection.


Recurrent Anaplastic Ependymoma

description: The reemergence of anaplastic ependymoma after a period of remission.


description: The presence of bacteria in the blood caused by an infected hemodialysis catheter.


name: Monoclonal Polymorphic Post-Transplant Lymphoproliferative Disorder


name: Autosomal Recessive Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

description: An autosomal recessive condition caused by mutation(s) in the HTRA1 gene, encoding serine protease HTRA1. It is characterized by subcortical infarcts and leukoencephalopathy resulting in progressive motor dysfunction and dementia.


Metastatic Carcinoma in the Pancreas

description: A carcinoma that has spread to the pancreas from another anatomic site.


Refractory Low Grade Astrocytoma

description: Low grade astrocytoma that is resistant to treatment.


AIDS-Related Herpes Zoster

description: An opportunistic infection caused by herpes zoster in a patient with AIDS.


name: Stage IV Renal Pelvis and Ureter Cancer AJCC v8

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat. N0: No regional lymph node metastasis. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm in greatest dimension; or multiple lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Ampulla of Vater Neuroendocrine Tumor

description: A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and periampullary region.


name: Posterior Fossa Ependymoma, Not Otherwise Specified

description: A circumscribed ependymoma that arises in the posterior fossa in which molecular analysis for DNA methylation profiling was unsuccessful or not reported.


name: Locally Advanced Prostate Adenocarcinoma

description: A prostatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Metastases to abdominal cavity

description: The spread of a malignant neoplasm from a primary site to an unspecified organ in the abdominal cavity.


Conjunctival Oncocytoma

description: A benign epithelial neoplasm that arises from the conjunctiva. It is characterized by the presence of oncocytic cells with abundant eosinophilic and granular cytoplasm.


Advanced Malignant Skin Neoplasm

description: A malignant neoplasm of the skin that has spread extensively to other anatomic sites or is no longer responding to treatment.


Pancreatic Alpha Cell Adenoma

description: A benign endocrine neoplasm arising from the alpha cells of the pancreas.  It produces glucagon.


name: Lugano Classification Advanced Stage Hodgkin Lymphoma AJCC v8

description: Advanced stage Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


name: Stage IIA Ampulla of Vater Cancer AJCC v8

description: Stage IIA includes: T3a, N0, M0. T3a: Tumor directly invading the pancreas (up to 0.5 cm). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IVB Vulvar Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (including pelvic lymph node metastasis). (from AJCC 8th Ed.)


name: Stage III Lentigo Maligna Melanoma AJCC v7

description: Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Reproductive Endocrine Neoplasm

description: A benign or malignant endocrine neoplasm that arises from the testis or the ovary.


Anemia due to Decreased Production

description: Anemia that results from a decreased rate of erythropoiesis.


name: Melanoma Metastatic in the Central Nervous System

description: A melanoma that has spread to the central nervous system from its original site of growth, through the hematogenous route.


Acromesomelic Dysplasia, PRKG2 Type

description: A genetic condition caused by mutation(s) in the PRKG2 gene, encoding cGMP-dependent protein kinase 2. It is characterized by acromelia and mesomelia.


name: Extragonadal primary germ cell tumor mixed stage I


Childhood Aneurysmal Bone Cyst

description: An aneurysmal bone cyst that occurs during childhood.


Stage IB Vulvar Cancer AJCC v8

description: Stage IB includes: T1b, N0, M0. T1b: Lesion measuring more than 2 cm, or any size with stromal invasion of more than 1.0 mm, confined to the vulva and/or perineum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Pancreatic Cancer AJCC v8

description: Stage IIA includes: T3, N0, M0. T3: Tumor measuring more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Clonal Hematopoiesis of Indeterminate Potential

description: A term that refers to the presence of somatic mutations in bone marrow or peripheral blood cells in individuals who may be cytopenic but do not have morphologic evidence of hematologic neoplasia. Its prevalence rises with age and is found in approximately 10% of individuals aged 70 to 80. It is associated with an increased risk of hematologic neoplasia. Mutations in the DNMT3A, TET2, or ASXL1 genes are usually identified. Approximately 10%-40% of individuals with age-related clonal hematopoiesis will progress to meet the diagnostic criteria for clonal hematopoiesis of indeterminate potential.