name: Diverticular Carcinoma of the Urinary Tract

description: A carcinoma that arises from a diverticulum in the urinary tract. Most histological subtypes of urinary tract carcinomas have been reported in urinary tract diverticula.


Stage IA Vulvar Cancer AJCC v8

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Stage IA includes: T1a, N0, M0. T1a: Lesion measuring 2 cm or less, confined to the vulva and/or perineum, and with stromal invasion of 1.0 mm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Osteosarcoma AJCC v7

description: Stage IIA includes: T1, N0, M0, G3, G4.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Stage I Prostate Cancer AJCC v6

description: Stage I includes: T1, N0, M0, G1.  T1: Tumor invades subepithelial connective tissue.  N0: No regional metastasis.  M0: No distant metastasis. G1: Well differentiated (slight anaplasia) (Gleason 2-4).  (AJCC 6th ed.)


name: Recurrent Sclerodermatous Graft Versus Host Disease

description: The reemergence of sclerodermatous graft versus host disease after a period of remission.


Malignant Solitary Fibrous Tumor

description: A malignant neoplasm of probable fibroblastic derivation. It is characterized by the presence of atypical round to spindle-shaped cells, increased cellularity, necrotic change and high mitotic activity.


Recurrent Dedifferentiated Liposarcoma

description: The reemergence of dedifferentiated liposarcoma after a period of remission.


name: Locally Advanced Primary Malignant Central Nervous System Neoplasm

description: A malignant neoplasm that arises from the central nervous system and has spread from its original site of growth to nearby tissues or lymph nodes.


Prostate Basal Cell Carcinoma

description: An invasive prostate carcinoma composed of prostatic basal cells.


Childhood Bone Hemangioma

description: A bone hemangioma that occurs during childhood.


Recurrent Diffuse Glioma

description: The reemergence of a diffuse glioma after a period of remission.


name: Myeloproliferative Chronic Myelomonocytic Leukemia

description: Chronic myelomonocytic leukemia characterized by the presence of a markedly elevated white blood cell count in the peripheral blood.


Immune-Mediated Coagulopathy

description: Disorders of coagulation caused by autoantibodies generated against native coagulation factors or therapeutically-administered hemostatic agents.


Mesenteric thrombosis

description: Formation of a blood clot (thrombus) in the lumen of a mesenteric vein or mesenteric artery.


Stage IVB Cervical Cancer AJCC v9

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis including inguinal lymph nodes, lung, liver, bone, or intraperitoneal metastases. Metastases to pelvic or paraaortic lymph nodes, or vagina are excluded. (from AJCC 9th Ed.)


name: Stage I Low Grade Adult Non-Hodgkin's Lymphoma


Breast Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm arising from the breast.


name: Lugano Classification Stage IE Adult Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Diffuse Astrocytoma, IDH-Wildtype

description: Diffuse astrocytoma lacking mutations in IDH1 or IDH2 genes.


Childhood Bone Sarcoma

description: A sarcoma that arises from the bone and occurs during childhood.


Infectious Meningoencephalitis

description: Inflammation of the meninges and brain caused by an infectious agent.


name: Gelatinous transformation of the bone marrow

description: A rare condition characterized by bone marrow fat cell atrophy, loss of hematopoietic cells, and bone marrow deposition of extracellular gelatinous substances containing mucopolysaccharides rich in hyaluronic acid. The pathogenesis is unknown. It presents with weight loss and anemia. It has been associated with infections, alcoholism, anorexia nervosa, cachexia, end stage renal disease, and cancers.


name: Nodular Sclerosis Classic Hodgkin Lymphoma, Syncytial Variant


Breast Ductal Hyperplasia

description: Hyperplasia of the epithelial cells in the breast ducts. It includes the atypical ductal hyperplasia, papillary intraductal hyperplasia, intraductal myoepitheliosis, and ductal hyperplasia of the usual type.


Secondary Parathyroid Gland Hyperplasia

description: Parathyroid gland hyperplasia that occurs in response to physiological stimuli (e.g., vitamin D deficiency, hyperphosphatemia, and hypocalcemia).


name: Metastatic Malignant Female Reproductive System Neoplasm

description: A malignant neoplasm that arises in the female reproductive system and has spread from its original site of growth to other anatomic sites.


Gastric Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the stomach. The Ki-67 index is higher than 20%.


Locally Advanced Esophageal Carcinoma

description: Esophageal carcinoma that has spread to nearby tissues or lymph nodes.


Childhood Anaplastic Ependymoma

description: An anaplastic ependymoma that occurs during childhood.


Tumor of the Thecoma/Fibroma Group

description: A sex cord-stromal tumor that arises from the ovary or the testis. Representative examples include fibroma, fibrosarcoma, and thecoma.


Listerial endocarditis

description: Endocarditis caused by bacterial infection with Listeria species.


Fat adherence syndrome

description: Violation of Tenon's capsule with prolapse of orbital fat into the sub-Tenon's space.


Stage I Cutaneous Melanoma AJCC v7

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


name: Locally Advanced Digestive System Neuroendocrine Neoplasm

description: A digestive system neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Advanced Non-Functioning Neuroendocrine Tumor

description: A non-functioning neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Urethrotrigonitis

description: Inflammation of both the urethra and the trigone of the urinary bladder.


name: Lugano Classification Stage III Hodgkin Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Stage III Ureter Cancer AJCC v8

description: Stage III includes: T3, N0, M0. T3: Tumor invades beyond muscularis into periureteric fat. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Meningioangiomatosis

description: A rare vascular malformation in the cerebral cortex and overlying leptomeninges.  It can occur sporadically or in association with neurofibromatosis type 2.


Unresectable Lymphoma

description: Lymphoma that is not amenable to surgical resection.


Refractory Solitary Fibrous Tumor

description: Solitary fibrous tumor that is resistant to treatment.


Central Osteoma

description: An osteoma that arises from the endosteum.


name: EBV-Positive Polymorphic B-Cell Lymphoproliferative Disorder, Not Otherwise Specified

description: An EBV-positive B-cell lymphoproliferative disorder characterized by altered tissue architecture and a polymorphic infiltrate that does not fulfill the criteria for the diagnosis of lymphoma and cannot be precisely categorized.


name: Deletion of the Short Arm of Chromosome 1 (1p) Associated Meningioma

description: A meningioma that is associated with deletion of chromosomal arm 1p.


Cockade nevus

description: A rare speckled nevus with concentric pattern of pigmentation and central papule surrounded by clear zone.


Localized Malignant Brain Neoplasm

description: A malignant brain neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


DDIT4L Acute Lymphoblastic Leukemia

description: A gene expression subtype of acute lymphoblastic leukemia characterized by its expression level of the DDIT4L gene.


name: Childhood Peripheral Nervous System Neoplasm

description: A neoplasm that affects the peripheral nervous system during childhood.


Drug/Toxin-Induced Aplastic Anemia

description: Bone marrow failure defined as pancytopenia, due to exposure to a known toxin or drug.


name: Germinotropic lymphoproliferative disorder caused by Human herpesvirus 8

description: A monotypic HHV8-positive lymphoproliferative disorder that usually occurs in HIV-negative individuals. It is characterized by the presence of HHV8-positive plasmablasts partially or completely replacing germinal centers. Coinfection with EBV is characteristic. In most cases, there is a favorable response to chemotherapy or radiation. (WHO 2017)


Unresectable Cervical Adenocarcinoma

description: Cervical adenocarcinoma that is not amenable to surgical resection.


Childhood Spitz Nevus

description: A Spitz nevus that occurs during childhood.


description: An alveolar rhabdomyosarcoma characterized by the presence of chromosomal translocation t(1;13)(p36;q14) that results in PAX7-FOXO1 gene fusion; or translocation t(2;13)(q35;q14) that results in PAX3-FOXO1 gene fusion.  Approximately 80% of alveolar rhabdomyosarcomas are fusion-positive.


name: AIDS-Related Diffuse Mixed Cell Lymphoma

description: A non-Hodgkin lymphoma occurring in HIV-positive patients.  It is composed of a mixture of lymphocytes of various sizes.


name: Vaginal Small Cell Neuroendocrine Carcinoma

description: A rare small cell neuroendocrine carcinoma that arises from the vagina.


Vulvar Cancer by AJCC v6 Stage

description: A term that refers to the staging of vulvar carcinoma according to the American Joint Committee on Cancer, 6th edition.


Adnexal Cribriform Carcinoma

description: A rare indolent adnexal carcinoma with a cribriform pattern.


name: Pancreatic Poorly Cohesive Adenocarcinoma

description: An adenocarcinoma that arises from the pancreas and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 7

description: Dyskeratosis congenita caused by mutation(s) in the ACD gene, encoding adrenocortical dysplasia protein homolog.


Columnar Cell Change of the Breast

description: A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini.  The acini are lined by one or two layers of columnar epithelial cells.  Apical cytoplasmic snouts may be present, but they are not prominent.  Secretions may be present in the lumina of the dilated acini.


name: Locally Advanced Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Recurrent Endometrial Endometrioid Adenocarcinoma

description: The reemergence of endometrial endometrioid adenocarcinoma after a period of remission.


Appendix Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of appendiceal carcinoma according to the American Joint Committee on Cancer, 7th edition. Carcinoid tumors are staged separately. (from AJCC 7th Ed.)


Premenstrual Dysphoric Disorder

description: A more severe form of premenstrual syndrome (PMS) with more extreme mood and physical symptoms. As with PMS, symptoms begin prior to an individual's menstrual cycle and typically taper off as menstruation begins.


Extra Lumbar Vertebra

description: A congenital anomaly of the spine, where an extra or supernumerary lumbar vertebra arises from below the 5th lumbar vertebra.


Stage IB1 Cervical Cancer

description: Stage IB1 includes: T1b1, N0, M0.  T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage III Bone Cancer AJCC v7

description: Stage III includes: T3, N0, M0, G3, G4. T3: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Stage IV Extragonadal Non-Seminomatous Germ Cell Tumor


description: Transient hyperinsulinism that occurs in response to neonatal stress resulting in prolonged neonatal hypoglycemia, which is distinct from transitional hypoglycemia of typical infants.


name: Acute Myeloid Leukemia Arising from Previous Myelodysplastic/Myeloproliferative Neoplasm

description: An acute myeloid leukemia developing in patients with a prior history of myelodysplastic/myeloproliferative neoplasm.


Lacrimal Drainage System Melanoma

description: An extremely rare melanoma that arises from the lacrimal drainage system.


AIDS-Related Malignant Neoplasm

description: Malignant neoplasms that develop in HIV infected patients.  The most common AIDS-related malignant neoplasms are Kaposi sarcoma, non-Hodgkin lymphoma, anal carcinoma, cervical carcinoma, and Hodgkin lymphoma.


Unresectable Acral Lentiginous Melanoma

description: Acral lentiginous melanoma that is not amenable to surgical resection.


Locally Advanced Vaginal Carcinoma

description: Vaginal carcinoma that has spread to nearby tissues or lymph nodes.


name: Metastatic Pancreatic Acinar Cell Carcinoma

description: Pancreatic acinar cell carcinoma that has spread from its original site of growth to another anatomic site.


Cervical Cancer by AJCC v8 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 8th edition.


Disseminated Juvenile Xanthogranuloma

description: Juvenile xanthogranuloma disseminated to extracutaneous sites including mucosal surfaces, lung, central nervous system, pituitary, lymph nodes, eye, liver, and bone marrow. It is characterized by the presence of lipid-laden, foamy histiocytes and Touton-type giant cells forming nodules in the affected anatomic sites.


name: Stage II Anal Canal Cancer AJCC v6 and v7

description: Stage II includes: (T2, N0, M0); (T3,N0, M0).  T2: Tumor more than 2 cm but not more than 5 cm in greatest dimension.  T3: Tumor more than 5 cm in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


Recurrent Myeloid Leukemia

description: The reemergence of myeloid leukemia after a period of remission.


name: Metastatic malignant neoplasm to stomach

description: A malignant neoplasm that has spread to the stomach from another organ or system, or from another primary gastric tumor. The primary gastric tumor is not in continuity with the metastatic lesion.  Representative examples of metastatic malignant neoplasms to the stomach include breast, lung, and esophageal metastatic carcinomas and melanomas.


Small cell glioblastoma

description: A morphologic variant of glioblastoma characterized by the presence of a highly proliferative and monotonous population of malignant small glial cells.


Acquired Hypogonadotropic Hypogonadism

description: Hypogonadotropic hypogonadism, the cause of which is not present from birth.


name: Metastatic Urethral Urothelial Carcinoma

description: A urethral urothelial carcinoma that has spread to another anatomical site.


Childhood Appendix Neuroendocrine Tumor

description: A neuroendocrine tumor that arises from the appendix during childhood. It is usually located in the tip of the appendix. The vast majority of cases are grade 1 neuroendocrine tumors.


Childhood Lymphoma by AJCC v8 Stage

description: Staging systems for Hodgkin and non-Hodgkin lymphomas of childhood. Different systems are used for Hodgkin lymphoma and non-Hodgkin lymphoma of childhood. Staging of childhood Hodgkin lymphoma is the same as for the adult counterpart and is based on the Lugano classification criteria. The Ann Arbor staging system has been found to be inappropriate for staging of the non-Hodgkin lymphomas of childhood. The St. Jude staging system has been widely accepted and remains the recommended staging system for non-Hodgkin lymphomas of childhood. (from AJCC 8th Ed.)


Hypoglossal Nerve Palsy

description: Partial or complete paralysis of the hypoglossal nerve.


name: Metastatic malignant neoplasm to extrahepatic bile ducts

description: A malignant neoplasm that has spread to the extrahepatic bile ducts from another anatomic site.  Representative examples include metastatic melanoma and metastatic breast and gastric carcinomas.


name: Cutaneous epithelioid angiomatoid nodule

description: A distinctive benign cutaneous vascular proliferation with prominent epithelioid morphology. It appears to be reactive. (WHO 2018)


Stage IIIC Cervical Cancer AJCC v9

description: Stage IIIC includes: IIIC1: TX, T0, T1-3, N1, M0; IIIC2: TX, T0, T1-3, N2, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N1: Tumor with regional lymph node metastasis to pelvic lymph nodes only. N2: Tumor with regional lymph node metastasis to para-aortic lymph nodes with or without positive pelvic lymph nodes.  M0: No distant metastasis. (from AJCC 9th Ed.)


Cervical Microglandular Hyperplasia

description: A benign endocervical gland proliferation characterized by the presence of closely packed glands composed of columnar to cuboidal cells with subnuclear mucin vacuoles. It is associated with progestins or pregnancy.


name: immune effector cell-associated neurotoxicity syndrome, grade 3

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 0, 1, or 2 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of greater than or equal to 9 (for children 12 and under), the ability of the affected individual to awaken only to tactile stimulus, clinical focal or generalized seizures that resolve rapidly, or non-convulsive seizures detected by electroencephalography (EEG) that resolve with intervention, and local cerebral edema evident on neuroimaging.


name: Extrahepatic Bile Duct Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts. The Ki-67 index is higher than 20%.


name: Ampulla of Vater Somatostatin-Producing Neuroendocrine Tumor

description: A well differentiated neuroendocrine tumor that arises from the ampulla of Vater and the periampullary region.  It produces somatostatin.


Recurrent Adenoid Cystic Carcinoma

description: The reemergence of adenoid cystic carcinoma after a period of remission.


Catheter related infection

description: An infection that arises secondary to catheter use.


Locally Advanced Cervical Carcinoma

description: A cervical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Unresectable Plexiform Neurofibroma

description: Plexiform neurofibroma that is not amenable to surgical resection.


Prostate Cancer by AJCC v8 Stage

description: A term that refers to the staging of prostate cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to adenocarcinomas and squamous cell carcinomas of the prostate gland. It does not apply to sarcomas, urothelial cell carcinomas, and urothelial carcinoma of bladder involving prostate. (from AJCC 8th Ed.)


Locally Recurrent Carcinoma

description: The reemergence of carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Advanced Transitional Cell Carcinoma

description: Transitional cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Refractory Vulvar Squamous Cell Carcinoma

description: Vulvar squamous cell carcinoma that is resistant to treatment.


name: Immune Checkpoint Inhibitor-Induced Dermatitis

description: Dermatitis associated with the therapeutic use of an immune checkpoint inhibitor.


Benign Supratentorial Neoplasms

description: A neoplasm that arises from above the cerebellar tentorium and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Desmoplastic Myxoid Tumor of the Pineal Region, SMARCB1-Mutant

description: A SMARCB1-deficient tumor of the brain arising in the pineal region. It is characterized by the presence of spindled and epithelioid cells with low-grade morphology that are embedded in a desmoplastic stroma alternating with various extents of loose myxoid matrix.


name: Platinum-Resistant Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that progresses between one and six months of completing platinum therapy.


name: Lymphomatoid Papulosis with DUSP22-IRF4 Gene Rearrangement

description: A variant of lymphomatoid papulosis associated with chromosomal rearrangements involving the DUSP22-IRF4 locus at 6p25.3.


name: Stage IIB Cervical Cancer AJCC v6 and v7

description: Stage IIB includes: T2b, N0, M0.  T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive

description: The reemergence of chronic myeloid leukemia, BCR-ABL1 positive after a period of remission.


Disorder of AMH

description: Abnormally high or low anti-Müllerian hormone levels.


Childhood Gastroblastoma

description: A gastroblastoma that occurs during childhood.


name: Drug and toxin-induced pulmonary arterial hypertension

description: A rare, progressive disorder characterized by abnormally high blood pressure in the pulmonary artery caused by obstruction and obliteration of the small pulmonary arteries due to drugs or toxins. The stimulant appetite suppressant aminorex fumarate and other stimulant anorectics such as the serotonin reuptake inhibitor dexfenfluramine, as well as other agents, including illegal substances have been reported as causative agents.


name: Squamous cell carcinoma with horn formation

description: A keratinizing squamous cell carcinoma characterized by the presence of horn pearls. Representative examples include squamous cell carcinomas of the face presenting as a cutaneous horn.


Hamartoma of brain

description: A hamartoma that occurs in the brain.


name: Congenital Reproductive System Abnormality

description: A disorder that affects the female or male reproductive system and is present at birth. Representative examples include ovarian agenesis, vaginal agenesis, and penile agenesis.


name: Secondary Central Nervous System Hodgkin Lymphoma

description: A Hodgkin lymphoma that has spread to the central nervous system following the initial presentation in another nodal or extranodal site.


name: Refractory Primary Central Nervous System Neoplasm

description: A primary central nervous system neoplasm that is resistant to treatment.


name: Prostate Ductal Adenocarcinoma, Solid Pattern

description: A prostate ductal adenocarcinoma characterized by the presence of cribriform and/or papillary patterns and areas of solid nests of malignant cells.


Parapharyngeal abscess

description: An abscess that develops in the soft tissues of the lateral pharyngeal space.


Chemical peritonitis

description: A non-infectious inflammation of the peritoneum.


Locally Advanced Ocular Melanoma

description: Ocular melanoma that has spread from its original site of growth to nearby tissues.


name: Refractory Malignant Leptomeningeal Neoplasm

description: Malignant leptomeningeal neoplasm that is resistant to treatment.


Bone Cancer by AJCC v8 Stage

description: A term that refers to the staging of appendicular skeleton, trunk, skull, and facial bones cancer, following the rules of the TNM AJCC v8 classification system. This staging system applies to osteosarcoma, chondrosarcoma, Ewing sarcoma, spindle cell sarcoma, hemangioendothelioma, angiosarcoma, fibrosarcoma/myofibroid sarcoma, chordoma, adamantinoma, and other cancers arising in the bone. It does not apply to primary malignant lymphoma of the bone and multiple myeloma. There are no AJCC prognostic stage groupings for spine and pelvis. (from AJCC 8th Ed.)


name: Lugano Classification Stage IV Childhood Hodgkin Lymphoma AJCC v8

description: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or noncontiguous extralymphatic organ involvement in conjunction with nodal stage II disease; or any extralymphatic organ involvement in nodal stage III disease. Stage IV includes any involvement of the bone marrow, liver, or lungs (other than by direct extension in stage IIE disease). (from AJCC 8th Ed.)


name: Low Grade Fallopian Tube Serous Adenocarcinoma

description: A slow-growing serous adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of low grade cytologic features and infrequent mitotic figures.


name: Recurrent Low Grade Fallopian Tube Serous Adenocarcinoma

description: The reemergence of low grade fallopian tube serous adenocarcinoma after a period of remission.


name: Mitochondrial Pyruvate Carrier Deficiency

description: An autosomal recessive condition caused by mutation(s) in the MPC1 gene, encoding mitochondrial pyruvate carrier 1. it is characterized by lactic acidosis with a normal lactate/pyruvate ratio, and global developmentally.


Minimal Deviation Melanoma

description: A melanocytic neoplasm displaying morphologic features that are intermediate between those of benign nevus and melanoma.  It is characterized by a nodular architectural growth resembling a melanoma, and a loss of nevus cell maturation.  The melanocytic cells forming the nodular growth are uniform, and they may display a high mitotic rate, but they do not show cytologic atypia.


Adult Benign Cerebral Neoplasm

description: A benign neoplasm of the cerebrum occurring in adults.


Stage IIA2 Cervical Cancer FIGO 2009

description: Cervical carcinoma limited to the upper two-thirds of the vagina and measuring more than 4 cm in diameter. (FIGO 2009)


name: Prostate Acinar Pleomorphic Giant Cell Adenocarcinoma

description: An extremely rare prostate acinar adenocarcinoma characterized by the presence of giant, bizarre anaplastic cells with pleomorphic nuclei and lack of a spindle cell component.


name: FIGO Stage IVA Gestational Trophoblastic Tumor


Cusp tear

description: A split located on a leaflet of a heart valve that prevents its complete closing, which can result in valvular dysfunction.


Disturbance in mood

description: A change in disposition or state of mind.


name: Papillary squamous cell carcinoma, non-invasive

description: A well differentiated squamous cell carcinoma characterized by a papillary, exophytic growth pattern, hyperkeratosis, and absence of invasion of adjacent tissues.


name: Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with Low Grade Dysplasia

description: An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized by the presence of low grade dysplasia.


Viral endocarditis

description: Endocarditis caused by a viral infection.


name: Refractory Neoplastic Post-Transplant Lymphoproliferative Disorder

description: Neoplastic post-transplant lymphoproliferative disorder that is resistant to treatment.


AHL Amyloidosis

description: An extremely rare type of amyloidosis characterized by the monoclonal deposition of immunoglobulin heavy chain and light chain fragments in organs and tissues.


Bone Rosai-Dorfman-Destombes Disease

description: Rosai-Dorfman-Destombes disease affecting the bone.


name: Unresectable Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that is not amenable to surgical resection.


name: Neoplasm, malignant, uncertain whether primary or metastatic

description: A malignant neoplasm in which the examined tissue can not be determined with certainty if it represents the primary site of tumor growth or tumor spread from another anatomic site.


Non-Neoplastic Brain Disorder

description: A non-neoplastic disorder that affects the brain. Representative examples include cerebrovascular disorder, hydrocephalus, and encephalitis.


Stage II Bone Sarcoma AJCC v7

description: Stage II includes: IIA (T1, N0, M0, G3, G4); IIB (T2, N0, M0, G3, G4).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Unresectable Urethral Urothelial Carcinoma

description: Urethral urothelial carcinoma that is not amenable to surgical resection.


name: Stage I Appendix Neuroendocrine Tumor AJCC v7

description: Stage I includes: T1, N0, M0. T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Florid Follicular Hyperplasia Post-Transplant Lymphoproliferative Disorder

description: An early lesion of post-transplant lymphoproliferative disorder with the morphologic appearance of florid follicular hyperplasia.


Malignant Hair Follicle Neoplasm

description: A neoplasm that arises from the hair follicle and metastasizes to other anatomic sites.


name: Pathologic Stage IIIB Merkel Cell Carcinoma AJCC v8

description: Stage IIIB includes: T1-4, N1b-3, M0. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. N2: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis. N3: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) with lymph node metastasis. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Acute promyelocytic leukemia - hypogranular variant

description: Acute promyelocytic leukemia in which the promyelocytes in the peripheral blood have paucity or absence of cytoplasmic granules and characteristic bilobed nuclei.


name: Locally Advanced Digestive System Neuroendocrine Tumor

description: A digestive system neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Infarction of brain due to migraine

description: Migraine associated with an ischemic brain lesion.


name: Prostate Acinar Oncocytic Adenocarcinoma

description: An exceptionally rare acinar prostate adenocarcinoma characterized by the presence of malignant large cells with granular eosinophilic cytoplasm.


name: Meningeal Chronic Myeloid Leukemia, BCR-ABL1 Positive

description: Infiltration of the meninges by chronic myeloid leukemia, BCR-ABL1 positive.


name: Stage IV Ampulla of Vater Neuroendocrine Tumor AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Congenital listeriosis

description: A bacterial infection by Listeria monocytogenes that is present at birth.


Mullerian Papilloma

description: A benign papillary neoplasm that arises from the cervix or vagina. It mostly occurs in prepubertal girls and rarely in adolescents or young adults. It is characterized by the presence of a fibrovascular core covered by cuboidal or columnar epithelial cells. Squamous metaplasia may be present. Cytologic atypia is absent.


Contact dermatitis caused by alkali

description: Contact dermatitis caused by exposure to alkalis.


Adult Diffuse Large Cell Lymphoma

description: A B-or T-cell non-Hodgkin lymphoma composed of a diffuse large cell lymphocytic infiltrate occurring in adults.


Aplastic anemia due to radiation

description: Aplastic anemia caused by excessive absorption of radiation by the bone marrow.


name: Atypical Neurofibromatous Neoplasm of Uncertain Biologic Potential

description: A premalignant neurofibromatous neoplasm characterized by the presence of at least two of the following features: cytologic atypia, hypercellularity, less than 3 mitotic figures per 10 HPFs, and loss of neurofibroma architecture. It is associated with an increased risk of progression to malignant peripheral nerve sheath tumor.


Leukemia, Radiation-Induced

description: Leukemia that is caused by radiation.


Congenital anomaly of lens

description: Any anatomic abnormality or physiologic dysfunction of the lens of the eye that is present at the time of birth.


Stage IIIB Esophageal Cancer AJCC v7

description: Stage IIIB includes: For squamous cell carcinoma: T3, N2, M0, Any G, Tumor location: Any. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: T3, N2, M0, Any G. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Brief depressive adjustment reaction

description: Temporary maladaptive depressive signs and symptoms associated with a life event.


Epithelioid glioblastoma

description: An IDH-wildtype glioblastoma characterized by the presence of large epithelioid cells with abundant eosinophilic cytoplasm, vesicular chromatin, and prominent nucleoli.


Non-Infectious Cystitis

description: An inflammation of the bladder which is not caused by an infection of the urinary tract. Representative examples include interstitial cystitis and radiation-induced cystitis.


Arsenical keratosis

description: A hyperkeratotic skin lesion that occurs in patients who have been exposed to arsenic.


name: Stage I Gestational Trophoblastic Neoplasm AJCC v8

description: Stage I includes: T1, M0. T1: Gestational trophoblastic neoplasm in which the tumor is confined to uterus. M0: No distant metastasis. (AJCC 8th Ed.)


Surfactant Protein C Deficiency

description: Deficiency of surfactant protein C. It leads to progressive lung fibrosis.


Hemorrhagic gastritis

description: Inflammation of the stomach resulting in bleeding.


Unresectable Neuroendocrine Carcinoma

description: Neuroendocrine carcinoma that is not amenable to surgical resection.


Uterine Ligament Ependymoma

description: A rare neoplasm that arises from the broad or other uterine ligaments and shows ependymal differentiation.


name: Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor

description: A usually indolent neuroendocrine neoplasm that almost exclusively arises in the second part of the duodenum. Rare sites of involvement include jejunum, pylorus, appendix, thymus, and lung. It is a triphasic tumor consisting of a mixture of epithelioid neuroendocrine cells, Schwann-like cells, and ganglion cell-like elements.


name: Stage 0 Esophageal Adenocarcinoma AJCC v7

description: Stage 0 includes: Tis (HGD), N0, M0, G1,GX.  Tis: High-grade dysplasia.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Squamous Hyperplasia

description: A hyperplasia of the squamous epithelial cells.


name: Malignant Neoplasm of Lung - Multiple Primary Sites

description: Lung cancer comprising malignant neoplasms from two or more sites, as determined by clinicoopathological assessment.


Epigastric hernia

description: Protrusion of abdominal cavity contents or pre-peritoneal fat through the abdominal wall between the umbilicus and the xiphoid process.


Lacrimal Gland Warthin Tumor

description: A rare benign tumor that arises from the lacrimal gland. It is characterized by an oncocytic epithelial component and dense lymphoid stroma.


Benign Dermal Neoplasm

description: A neoplasm that arises from the dermis and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Localized Prostate Adenocarcinoma

description: An adenocarcinoma that arises from the prostate and has not spread to other anatomic sites.


Congenital musculoskeletal anomalies

description: An abnormality of the musculoskeletal system that is present at birth or detected in the neonatal period.


Cutaneous Melanoma by AJCC v7 Stage

description: A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v7 classification system.


Advanced Favorable Hodgkin Lymphoma

description: An advanced Hodgkin lymphoma with favorable prognosis.


Non-Neoplastic Pleural Disorder

description: A non-neoplastic disorder that affects the pleura.  Representative examples include pleural infection and pneumothorax.


Childhood Compound Nevus

description: A compound nevus that occurs during childhood.


Trigeminal nerve palsy

description: Partial or complete paralysis of the trigeminal nerve.


Overt Stroke

description: A cerebral infarction that is evident by new neurological symptoms lasting greater than 24 hours or having an area of diffusion restriction or a T2 or fluid-attenuated inversion recovery (FLAIR) hyperintensity on an MRI of the brain that was consistent with the neurological findings.


name: Placental Site Nodule and Plaque Occurring in the Fallopian Tube

description: A rare non-neoplastic trophoblastic disorder characterized by the presence of remnants of intermediate trophoblasts in the fallopian tube from a previous pregnancy.


Locally Advanced Pancreatic Carcinoma

description: A pancreatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Childhood Acute Erythroid Leukemia

description: An acute erythroid leukemia occurring in children.


name: Verrucous carcinoma of the oral cavity stage I


name: Genetic Syndrome Associated with Congenital Heart Defect

description: Genetic anomalies and collections of malformations that are known to cluster together that can be associated with congenital heart defects. (ACC/AHA)


name: Refractory Endometrial Serous Adenocarcinoma

description: Endometrial serous adenocarcinoma that is resistant to treatment.


name: Lacrimal Drainage System Adenoid Cystic Carcinoma

description: A carcinoma that arises from the lacrimal sac. It is characterized by the presence of malignant epithelial cells that form cribriform, tubular, and solid patterns.


name: Recurrent Endometrial Dedifferentiated Carcinoma

description: The reemergence of endometrial dedifferentiated carcinoma after a period of remission.


Adult Benign Brain Neoplasm

description: A benign neoplasm of the brain occurring in adults.


name: Metastatic Prostate Adenocarcinoma with Neuroendocrine Differentiation

description: Prostate adenocarcinoma with neuroendocrine differentiation that has spread from its original site of growth to another anatomic site.


name: Clear Cell Tumor with Melanocytic Differentiation and ACTIN-MITF Translocation

description: A MITF pathway-activated melanocytic tumor characterized by a cytogenetic translocation between ACTIN and MITF genes that results in ACTIN-MITF gene fusion. It presents as a single non-pigmented cutaneous nodule in the distal extremities or trunk. It is composed of large cells with clear cytoplasm that exhibit melanocytic differentiation and proliferate in the dermis without an intraepidermal component. Extension in the subcutaneous tissue is frequently seen. Atypical nuclear features may be present. It has an indolent clinical course.


name: Metastatic Platinum-Resistant Malignant Germ Cell Tumor

description: A platinum-resistant malignant germ cell tumor that has spread from its original site of growth to another anatomic site.


name: Adnexal Adenocarcinoma, Not Otherwise Specified

description: An adnexal carcinoma with ductal/glandular differentiation lacking specific histological features that would allow further classification. (WHO 2018)


description: A hematologic malignancy that arises in a patient with a history of organ transplantation.


Childhood Benign Skin Neoplasm

description: A childhood neoplasm that arises from the skin and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Recurrent Endometrial Cancer

description: The reemergence of endometrial carcinoma after a period of remission.


name: Complex endometrial hyperplasia without atypia

description: A hyperplasia characterized by excessive proliferation of endometrial cells, resulting in the formation of complex epithelial structures. Epithelial atypia is absent.


Chest Wall Disorder

description: A non-neoplastic or neoplastic disorder that affects the structures of the chest wall.  Representative examples include infection, chest wall lipoma, and chest wall lymphoma.


Metastatic adenoid cystic carcinoma

description: An adenoid cystic carcinoma that has spread from the original site of growth to other anatomic sites.


Epstein-Barr virus infection recurrent

description: An Epstein-Barr virus infection that has recurred after a period of remission.


Cervical myelocele

description: Herniation of spinal cord tissue and meninges through a defect in the cervical region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


name: Metastatic Malignant Neoplasm in the Lacrimal System

description: A malignant neoplasm that has spread from its original site of growth to the lacrimal gland or lacrimal drainage system.


Nutritional Hypophosphatemic Rickets

description: Hypophosphatemic rickets due to insufficient dietary phosphate intake or absorption.


Adult Intracranial Germ Cell Tumor

description: A germ cell tumor that arises within the cranium and occurs during adulthood.


name: Stage I Childhood Retinoblastoma by Toronto Guidelines v2

description: Enucleation with negative margins. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Phlebitis of portal vein

description: Inflammation of the portal vein.


Basal-Like Prostate Carcinoma

description: Prostate carcinoma in which the CD49f signature is increased, the luminal markers and androgen receptor expression and signaling (androgen activity pathway) are not increased, and the proliferation score is higher than the luminal A prostate carcinoma.


Stage II Gallbladder Cancer AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Tumor invades perimuscular connective tissue; no extension beyond serosa or into liver.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Gestational diabetes mellitus class A2

description: Carbohydrate intolerance first diagnosed during pregnancy. Diagnosis from abnormal oral glucose tolerance test (OGTT) and abnormal fasting or post-prandial glucose levels. Euglycemia achieved with medication.


name: Stage II Intermediate Grade Adult Non-Hodgkin's Lymphoma


name: Stage IIIA Uterine Corpus Cancer AJCC v8

description: Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus carcinoma or carcinosarcoma with tumor involving the serosa and/or adnexa (direct extension or metastasis). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Unresectable Digestive System Carcinoma

description: Digestive system carcinoma that is not amenable to surgical resection.


Recurrent basal cell carcinoma

description: The reemergence of basal cell carcinoma after a period of remission.


Refractory Childhood Malignant Neoplasm

description: A childhood malignant neoplasm that does not respond to treatment.


NADH Dehydrogenase Deficiency

description: A rare metabolic disorder characterized by the deficiency of mitochondrial NADH dehydrogenase component of complex I. Signs and symptoms include cardiomyopathy, encephalopathy, enlarged head, and progressive leukodystrophy.


name: Cutaneous Melanoma by AJCC v8 Pathologic Stage

description: A term that refers to the pathologic staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system.


Current EBV Infection

description: Epstein-Barr virus infection is evident at the time of testing.


Infection pyogenic

description: An infection caused by pus-producing organisms.


name: Childhood Ependymoma by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood ependymoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


Pulmonary Embolism Related to COVID-19

description: Pulmonary embolism in a patient with probable or confirmed acute COVID-19.


Third degree uterine prolapse

description: The uterus has descended below the level of the hymen and protrudes through the opening of the vagina.


Non-Neoplastic Chest Wall Disorder

description: A non-neoplastic disorder that affects the structures of the chest wall.


name: Stage III Pancreatic Cancer AJCC v6 and v7

description: Stage III includes: T4, Any N, M0. T4: Tumor involves the celiac axis or the superior mesenteric artery.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


name: Recurrent Acute Myeloid Leukemia with Multilineage Dysplasia

description: The reemergence of acute myeloid leukemia with multilineage dysplasia after a period of remission.


Stage IVB Appendix Carcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1b, G2, G3, or GX. M1b: Intraperitoneal metastasis only, including peritoneal mucinous deposits containing tumor cells. G2: Moderately differentiated. G3: Poorly differentiated. GX: Grade cannot be assessed.  (AJCC 8th ed.)


name: Metastatic Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that has spread to another anatomic site.


name: Non-Neoplastic Trigeminal Nerve Disorder

description: A non-neoplastic disorder affecting the trigeminal nerve.


name: Stage II Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Tumor extends beyond kidney but completely resected. Tumor penetrates renal capsule. Tumor in lymphatics or veins of renal sinus. Tumor in renal vein with margin not involved. No nodal or hematogenous metastases. Negative margins. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Unresectable Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is not amenable to surgical resection.


Pelvic Floor Disorders

description: A disorder affecting the muscles of the pelvic floor.


name: FIGO Stage IV Gestational Trophoblastic Tumor

description: Gestational trophoblastic tumor in all other metastatic sites.


Focal KATP-Associated Hyperinsulinism

description: KATP-associated hyperinsulinism in which there is an area of adenomatous beta-cell hyperplasia. This condition results from paternal recessive mutation(s) in either the ABCC8 or the KCNJ11 gene and paternal uniparental isodisomy of chromosome region 11p15 with loss of tumor suppressor genes expressed from the maternally inherited chromosome.


Locally Advanced High Grade Sarcoma

description: High-grade sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Benign Childhood Central Nervous System Neoplasm

description: A childhood neoplasm that arises from the central nervous system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Stage II Non-Contiguous Adult Diffuse Small Cleaved Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Enteric campylobacteriosis

description: A gastrointestinal infection attributed to the bacteria campylobacter. It is usually contracted by consuming raw or undercooked poultry or consuming a food that has been in contact with raw poultry. It is characterized by abdominal pain, fever, and  diarrhea and usually resolves in two to five days.


name: FIGO Stage IIIB Gestational Trophoblastic Tumor


Rhinovirus infection

description: An infectious process caused by rhinovirus. The virus usually causes upper respiratory infections, but can infect the lower tract as well.


Stage IVB Vulvar Cancer AJCC v6 and v7

description: Stage IVB includes: Any T, Any N, M1.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 6th and 7th eds.)


Hemophilus influenza infection

description: An infection that is caused by the organism Hemophilus influenza.


name: Recurrent Adult Diffuse Mixed Cell Lymphoma

description: The reemergence of adult diffuse mixed cell lymphoma after a period of remission.


Refractory Carcinoma

description: A carcinoma that does not respond to treatment.


Multifocal Glioblastomas

description: The occurrence of multiple and independent glioblastomas that are unrelated to inherited neoplastic syndromes.


name: Metastatic Digestive System Neuroendocrine Tumor G3

description: Digestive system neuroendocrine tumor G3 that has spread from its original site of growth to another anatomic site.


Gastroenteritis enteroviral

description: Gastroenteritis resulting from an infection with enterovirus.


Accelerated Phase Primary Myelofibrosis

description: Rapid progression of primary myelofibrosis, characterized by the presence of myeloblasts accounting for 10-19% of the peripheral blood white cells or the nucleated cells in the bone marrow.


name: Resectable Platinum-Resistant Malignant Germ Cell Tumor

description: A platinum-resistant malignant germ cell tumor that is amenable to surgical resection.


name: Childhood Favorable Prognosis Hodgkin Lymphoma

description: A Hodgkin lymphoma with favorable prognosis that occurs during childhood.


Advanced Gallbladder Carcinoma

description: Gallbladder carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Prostate Carcinoma by Gene Expression Profile

description: A header term that includes the following prostate carcinoma subtypes determined by gene expression profiling: luminal A prostate carcinoma, luminal B prostate carcinoma, and basal-like prostate carcinoma.


Prostatic Basal Cell Hyperplasia

description: A type of prostatic hyperplasia.  It is characterized by the presence of nodules of dark basal cells around residual prostatic secretory cells.


name: Recurrent Acute Myeloid Leukemia Not Otherwise Specified

description: The reemergence of acute myeloid leukemia not otherwise specified after a period of remission.


Benign neoplasm of cranial nerves

description: A neoplasm that arises from a cranial nerve and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Refractory Acute Leukemia of Ambiguous Lineage

description: Acute leukemia of ambiguous lineage that is resistant to treatment.


Childhood Giant Cell Glioblastoma

description: A giant cell glioblastoma that occurs during childhood.


Syphilitic endocarditis

description: Endocarditis secondary to syphilis.


Non-Neoplastic Retinal Disorder

description: A non-neoplastic disorder that affects the retina.


description: The reemergence of a myelodysplastic/myeloproliferative neoplasm after a period of remission.


name: Childhood Acute Myeloid Leukemia Not Otherwise Specified

description: Acute myeloid leukemias that occur in childhood and do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related.  This category includes entities classified according to the French-American-British classification scheme.


Cervical Blue Nevus

description: A nevus that arises from the cervix. It is characterized by the presence of benign, heavily pigmented dendritic melanocytes.


description: Gastritis that is characterized by erosion of the mucosal surface.


Congenital Disruption

description: A morphologic defect of an organ, part of an organ, or a larger region of the body that results from the extrinsic breakdown of, or an interference with, an originally normal developmental process.


Transient Organic Mental Disorder

description: An organic mental disorder that is temporary in nature.


Atrial Septum Lipomatous Hypertrophy

description: A condition in which deposits of fat accumulate within the interatrial septum.


name: EBV-Related Clonal Post-Transplant Lymphoproliferative Disorder

description: A clonal lymphoproliferative disorder that develops following organ transplantation and is associated with Epstein-Barr virus infection.


name: Shared Neoantigen-Positive Malignant Solid Neoplasm

description: A malignant solid neoplasm that expresses unique tumor-specific neoantigens across a subset of patients.


Radiation-Related Sarcoma

description: A sarcoma that arises in the bones or soft tissues following exposure to ionizing or non-ionizing radiation.


name: Recurrent Chronic Myelomonocytic Leukemia

description: The reemergence of chronic myelomonocytic leukemia after a period of remission.


Appendix Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the appendix. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Stage IA1 Cervical Cancer AJCC v9

description: Stage IA1 includes: T1a1, N0, M0. T1a1: Tumor with measured stromal invasion equal or less than 3 mm in depth. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Acute Myeloid Leukemia with t(3;12)(q26.2;p13.2); ETV6-MECOM

description: An acute myeloid leukemia associated with t(3;12)(q26.2;p13.2) resulting in the expression of ETV6-MECOM fusion gene.


name: Advanced Gastric Neuroendocrine Carcinoma

description: A gastric neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Connective and Soft Tissue Disorder

description: A non-neoplastic or neoplastic disorder that affects the connective and soft tissue.


name: Metastatic Proximal Gastric Adenocarcinoma

description: A proximal gastric adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Skin Basal Cell Carcinoma with Adnexal Differentiation

description: A basal cell carcinoma of the skin that is characterized by adnexal differentiation.


name: Central Nervous System Histiocytic and Dendritic Cell Neoplasm

description: A neoplasm that originates from histiocytes and accessory cells and affects the central nervous system.  It is usually associated with the presence of identical tumors outside the central nervous system.  Representative examples include Langerhans cell histiocytosis, histiocytic sarcoma, and follicular dendritic cell sarcoma.


name: Metastatic Bladder Nested Urothelial Carcinoma

description: Bladder nested urothelial carcinoma that has spread to another anatomic site.


name: Perianal Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process involving the squamous epithelium of the perianal skin. Clinically, it usually presents as a white or red area in the perianal skin. Morphologically, it is characterized by full thickness dysplasia of the squamous epithelium and sometimes of the pilosebaceous epithelium. Human papillomavirus DNA sometimes may be identified in the dysplastic epithelium. It may recur after treatment, however only a small percentage of cases progress to squamous cell carcinoma.


Infectious Mediastinitis

description: An acute or chronic infectious process affecting the mediastinum.


Placenta, Retained

description: After delivery of neonate, placental retention that requires clinical intervention such as manual extraction, curettage or uterotonic medications.


name: Merkel Cell Polyoma Virus-Positive Merkel Cell Carcinoma

description: A Merkel cell carcinoma that is associated with Merkel cell polyoma virus infection.


Infratentorial Glioblastoma

description: A glioblastoma that occurs in the infratentorial region.


name: Malignant Lymphoma Follicular, Large Cleaved Cell Type


name: Mixed Epithelial and Mesenchymal Hair Follicle Neoplasm

description: A trichoblastoma characterized by the presence of neoplastic epithelial cell forming nodules. There are palisaded basaloid cells present at the periphery and pale larger cells with vesicular nuclei, prominent nucleoli, and abundant cytoplasm present at the center of the nodules. The epithelial cells are admixed with numerous small lymphocytes and occasional large multinucleated cells that resemble Reed-Sternberg cells.


name: Congenital Abnormalities of Erythrocyte Differentiation or Function

description: Inherited disorders involving abnormalities of red blood cell function, structure, or production. Some diseases in this group may be associated with bone marrow failure, neutropenia, and/or thrombocytopenia.


name: Metastatic malignant neoplasm to bone marrow

description: The spread of a malignant neoplasm from its original site of growth to the bone marrow.


name: Utricle-Associated Mucosal Gland Hyperplasia

description: A benign microacinar proliferation occurring exclusively in the area of the utricle.


Acquired Cytomegaloviral Infection

description: An infection with the Cytomegalovirus that is not present from birth.


Biliary System Disorder

description: A non-neoplastic or neoplastic disorder that affects the intrahepatic or extrahepatic bile ducts or the gallbladder. Representative examples of non-neoplastic disorders include cholangitis and cholecystitis. Representative examples of neoplastic disorders include extrahepatic bile duct adenoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.


Adrenal Gland Hyperplasia II

description: Decreased activity of the enzyme 3-beta-hydroxysteroid dehydrogenase, associated with mutation(s) in the HSD3B2 gene. The lack of activity of this enzyme produces a type of congenital adrenal hyperplasia.


Refractory Gastric Adenocarcinoma

description: Gastric adenocarcinoma that is resistant to treatment.


Stage IV Vaginal Cancer AJCC v6 and v7

description: Stage IV includes: IVA: (T4, Any N, M0) and IVB: (Any T, Any N, M1).  T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify tumor as T4).  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 6th and 7th eds.)


Early Stage Cervical Carcinoma

description: A stage term that refers to cervical carcinoma stages IA, IB, and IIA.


name: Unresectable Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: Extrapulmonary small cell neuroendocrine carcinoma that is not amenable to surgical resection.


name: Unresectable Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that is not amenable to surgical resection.


name: Prostatic Clear Cell Cribriform Hyperplasia

description: A rare type of prostatic hyperplasia. It is characterized by hyperplastic glandular cells with clear cytoplasm.


Metastatic Malignant Mesothelioma

description: Malignant mesothelioma that has spread from its original site of growth to another anatomic site.


Stage IA Fallopian Tube Cancer AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Fallopian tube cancer with tumor limited to fallopian tube surface; no malignant cells in ascites or peritoneal washings N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Digestive System Small Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from any part of the gastrointestinal system.  It is characterized by the presence of malignant small cells.


Early Localized Lyme Disease

description: An early stage of Lyme disease that may present within 3-30 days after a tick bite with a red, concentrically-expanding rash (erythema migrans), fatigue, chills, fever, headache, muscle and joint aches, and swollen lymph nodes.


Deficiency of vitamin D3

description: Abnormally low concentration of vitamin D3 (cholecalciferol) in the blood.


Abdominal Abscess

description: An abscess within the abdomen.


Arteriovenous fistula thrombosis

description: Partial or complete occlusion of the lumen within an arteriovenous fistula by a thrombus.


Stage IIIA Anal Cancer AJCC v8

description: Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor 2 cm or smaller. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. N1: Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Locally Advanced Small Cell Neuroendocrine Carcinoma

description: A small cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Benign Hair Follicle Neoplasm

description: A neoplasm that arises from the hair follicle and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Childhood Breast Neoplasm

description: A neoplasm that affects the breast and occurs during childhood.


Nutritional Calcium Deficient Rickets

description: Nutritional rickets due to dietary deficiency of calcium.


name: Hypogonadotropic Hypogonadism with Adrenal Hypoplasia Congenita

description: Hypogonadotropic hypogonadism with congenital adrenal hypoplasia associated with mutation(s) in the NR0B1 gene (on the X chromosome).


Adult Atypical Meningioma

description: An atypical meningioma that occurs during adulthood.


Neurological ventriculitis

description: Inflammation of a cerebral ventricle.


name: Stage IIIB Esophageal Adenocarcinoma AJCC v7

description: Stage IIIB includes: T3, N2, M0, Any G. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Obstructed Megaureter

description: A megaureter in which there is obstruction to the flow of urine at the ureterovesical junction.


Hindgut Neuroendocrine Tumor G2

description: A neuroendocrine tumor grade 2 that arises from the sigmoid colon, descending colon, or rectum.


name: Locally Advanced Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage II Centroblastic Follicular Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Extrahepatic bile duct cancer stage II

description: Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor invades the liver, gallbladder, pancreas, and/or unilateral branches or the portal vein (right or left) or hepatic artery (right or left).  N1: Regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Breast hyperplasia

description: A general term that refers to hyperplastic proliferations of the epithelial cells in the breast parenchyma.  Examples include atypical ductal hyperplasia, usual ductal hyperplasia, columnar cell hyperplasia, and atypical lobular hyperplasia.


Testicular Cystic Trophoblastic Tumor

description: A rare trophoblastic neoplasm that arises in metastatic sites of testicular mixed germ cell tumors following chemotherapy, or is part of treated or untreated testicular mixed germ cell tumors, or is secondary to either chemotherapy-induced or spontaneous regression of testicular choriocarcinoma. It is characterized by the presence of cysts lined by squamoid trophoblastic cells. The cysts are often compressed surrounded by other germ cell components.


Nickel Metabolic Disorder

description: A storage disorder that results from impaired metabolism of nickel.


name: Recurrent Polymorphous Low Grade Neuroepithelial Tumor of the Young

description: The reemergence of polymorphous low-grade neuroepithelial tumor of the young after a period of remission.


Malignant neoplasm of bladder recurrent

description: The reemergence of a malignant bladder neoplasm after a period of remission.


Gastrointestinal carcinoma in situ

description: An intraepithelial carcinoma arising from any part of the digestive system without evidence of invasion.


Urostomy Prolapse

description: Displacement of the urostomy.


Lumbar Meningocele

description: A congenital abnormality in the lumbar region of the spine in which the meninges protrude through a defect in the spinal column.


name: Metastatic Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: Extrapulmonary large cell neuroendocrine carcinoma that has spread to another anatomic site.


name: Clinical Stage 0 Cutaneous Melanoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Oropharyngeal candidiasis

description: Infection of the oropharynx with, or disease caused by, Candida, especially C. albicans. This disease usually results from debilitation (as in immunosuppression and especially AIDS), physiologic change, prolonged administration of antibiotics, and iatrogenic and barrier breakage. SYN candidosis, moniliasis.


name: Unresectable Genitourinary System Carcinoma

description: Genitourinary system carcinoma that is not amenable to surgical resection.


Primary Cutaneous Mucinous Carcinoma

description: A rare low-grade carcinoma of the sweat glands. The most common sites are eyelids, scalp, axilla, face and trunk. It is histologically characterized by proliferating ducts until the overproduction of mucin creates islands of tumor cells, essentially floating in mucinous pools (Rosai J. Ackerman's Surgical Pathology).


name: Unresectable Vulvar Squamous Cell Carcinoma

description: Vulvar squamous cell carcinoma that is not amenable to surgical resection.


Lupus encephalitis

description: Encephalitis that is associated with systemic lupus erythematosus.


Childhood depression

description: Similar to depression in adults, childhood depression is characterized by a prolonged depressed or irritable mood accompanied by a significant loss of interest in activities, changes in appetite or sleep, decreased energy, feelings of worthlessness, and/or recurrent thoughts of death or suicide.


Adult Astroblastoma, MN1-Altered

description: An astroblastoma, MN1-altered that occurs during adulthood.


Stage IIB Esophageal Carcinoma

description: Stage IIB includes: For squamous cell carcinoma: (T2-3, N0, M0, G2-3, Tumor location: Upper, middle); (T1-2, N1, M0, Any G, Tumor location: Any).  For adenocarcinoma: (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Congenital spondylolysis

description: Spondylolysis, the cause of which is present from birth.


name: Acute Leukemia of Ambiguous Lineage, Not Otherwise Specified

description: Acute leukemia of ambiguous lineage, expressing combinations of markers that do not allow for its classification as either acute undifferentiated leukemia or mixed phenotype acute leukemia, and definitive classification along a single lineage is difficult. (WHO 2017)


Unresectable Esophageal Carcinoma

description: A carcinoma that arises from the esophagus and is not amenable to surgical resection.


Papillary mucinous cystadenocarcinoma

description: An invasive adenocarcinoma characterized by cystic changes, papillary growth pattern, and the presence of malignant glandular cells which contain intracytoplasmic mucin.


name: Metastatic Primary Malignant Brain Neoplasm

description: A malignant neoplasm that arises from the brain and has spread from its original site of growth to other sites.


Gastric Hepatoid Adenocarcinoma

description: A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of large polygonal malignant cells with eosinophilic cytoplasm resembling hepatocytes.


Anal squamous cell carcinoma metastatic

description: Anal squamous cell carcinoma that has spread from its primary site to another anatomic site.


name: Recurrent Endometrial Clear Cell Adenocarcinoma

description: The reemergence of endometrial clear cell adenocarcinoma after a period of remission.


Bone Sarcoma by AJCC v7 Stage

description: A term that refers to the staging of bone sarcoma, following the rules of the TNM AJCC v7 classification system.


CTRP Clinical Finding

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A finding concept that has been requested by CTRP to be used in the disease field for abstraction and search of clinical trials.


name: Recurrent Large Cell Neuroendocrine Carcinoma

description: The reemergence of large cell neuroendocrine carcinoma after a period of remission.


Diffuse neurofibroma

description: A rare neurofibroma with an infiltrative growth pattern.  It involves the skin and subcutaneous tissue and grows in a plaque-like fashion.  Malignant transformation is rare.


Gastric Carcinoma with Lymphoid Stroma

description: A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of prominent lymphocytic stromal infiltration and poorly formed tubular structures.


name: Myelodysplastic/Myeloproliferative Neoplasm, Not Otherwise Specified

description: A myelodysplastic/myeloproliferative neoplasm that does not meet the criteria of other myelodysplastic/myeloproliferative neoplasms, myelodysplastic syndromes, and myeloproliferative neoplasms. It is associated with cytopenia, blasts less than 20% in bone marrow and peripheral blood, thrombocytosis, and absence of genetic abnormalities associated with myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions.


Naevus spider acquired

description: A non-congenital, benign vascular lesion with a central punctum (arteriole) that is surrounded by thin-walled capillaries in a radial pattern. It occurs as the result of the dilatation of pre-existing vessels and is most often an incidental finding. The lesion may also be found in association with hypermetabolic states or chronic disease.


name: Metastatic Malignant Neoplasm in the Pelvic Cavity

description: The spread of a malignant neoplasm from a primary site to the pelvic cavity.


name: Childhood Acute Lymphoblastic Leukemia CNS-Negative Toronto Guidelines v2

description: No clinical signs of CNS involvement and no blasts in CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Refractory Acute Undifferentiated Leukemia

description: Acute undifferentiated leukemia that does not respond to treatment.


Stage IV Urethral Cancer AJCC v8

description: Stage IV includes: (T4, N0, M0); (T4, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: For male penile urethra and female urethra: Tumor invades other adjacent organs (e.g., invasion of the bladder wall). For prostatic urethra: Tumor invades other adjacent organs (e.g., extraprostatic invasion of the bladder wall, rectal wall). N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. N2: Multiple regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Parainfluenza Virus Infections

description: A viral infection caused by a parainfluenza virus, typically resulting in infections of the lower respiratory tract.


name: Skin disorder arising from mental factors

description: A skin disorder for which mental factors play a causative role.


Aleukemic myeloid leukemia

description: Myeloid leukemia presenting with leukemic infiltration of tissues and normal or decreased leukocyte count in the peripheral blood.


Virus-Related Carcinoma

description: Carcinoma that develops in the context of an individual infected with a virus.


Vulvar Melanocytic Nevus

description: A benign, atypical, or dysplastic melanocytic nevus that arises from the vulva.


Enterotoxigenic E coli Infection

description: A pathotype of Escherichia coli, which is a gram-negative bacteria that is transmitted through the fecal-oral route. It has an incubation period of 10-72 hours and a duration of 1-5 days. Symptoms may include acute, occasionally severe diarrhea without fever.


name: Intestinal Metaplasia of Bladder Urachal Epithelium


name: Complete Atrioventricular Canal Defect Balanced

description: Atrioventricular septal defect in which the atrioventricular junction is shared evenly between the left ventricle and right ventricle.


Benign Liver Non-Epithelial Neoplasm

description: A non-epithelial neoplasm that arises from the liver and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include hemangioma, angiomyolipoma, and solitary fibrous tumor.


Endometrioid intraepithelial neoplasia

description: A neoplastic clonal expansion of endometrial glands characterized by cytologic changes of the epithelium and the presence of an increased number of endometrial glands. The glands form crowded aggregates with tubular or branching patterns which are cytologically distinct from the background architectural and cytological pattern. It is associated with molecular changes seen in endometrioid endometrial carcinoma, including microsatellite instability, PAX2 inactivation, and PTEN, KRAS, and CTNNB1 gene mutations.


name: AIDS-Related Malignant Cervical Neoplasm

description: A malignant neoplasm that arises from the cervix in a patient with acquired immunodeficiency syndrome. This category includes cervical carcinoma, Kaposi sarcoma, and non-Hodgkin lymphoma.


Pericarditis secondary to uremia

description: Inflammation of the pericardium associated with chronic kidney failure.


Refractory Chronic Leukemia

description: Chronic leukemia that is resistant to treatment.


Testicular cancer metastatic

description: A malignant germ cell tumor that arises from the testis and has spread to another anatomic site.


name: Non-Functioning Pancreatic Neuroendocrine Tumor G1

description: A low grade well differentiated neoplasm with neuroendocrine differentiation that arises from the pancreas. It is characterized by the absence of a hormone-related clinical syndrome.


name: Childhood Connective and Soft Tissue Neoplasm

description: A soft tissue or bone neoplasm that occurs during childhood.


name: Arterial Thrombosis Related to Vascular Access Complication

description: The formation of a thrombus in the artery as a direct result of an activity associated with vascular access.


name: Lugano Classification Stage I Hodgkin Lymphoma AJCC v8

description: Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


name: Malignant Osteoclastic Giant Cell-Rich Tumor of Bone

description: A giant cell tumor that arises from the bone and is characterized by the presence of a malignant cellular component.


name: Refractory Sclerodermatous Graft Versus Host Disease

description: Sclerodermatous Graft Versus Host Disease that is resistant to treatment.


Infectious Encephalomyelitis

description: An infectious process that affects the brain and spinal cord tissues. It is usually caused by viruses.


Acral nevus

description: A melanocytic nevus that arises from the palms, soles, and nails.


name: Early T Precursor Acute Lymphoblastic Leukemia with BCL11B Rearrangement

description: An early T precursor acute lymphoblastic leukemia associated with the presence of BCL11B gene rearrangement.


Stage IIA2 Cervical Cancer AJCC v8

description: Stage IIA2 includes: T2a2, Any N, M0. T2a2: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion more than 4.0 cm in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


name: Acute Myeloid Leukemia with STAG2 Mutation

description: An acute myeloid leukemia associated with STAG2 gene mutation.


Liver Germ Cell Tumor

description: A benign or malignant extragonadal germ cell tumor that arises from the liver. Representative examples include teratoma and yolk sac tumor.


name: Refractory Fallopian Tube Mucinous Adenocarcinoma

description: Fallopian tube mucinous adenocarcinoma that is resistant to treatment.


name: Borrelia Burgdoferi-Associated Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: Primary cutaneous marginal zone lymphoproliferative disorder that arises from chronically stimulated lymphoid tissue in the skin in response to Borrelia burgdoferi infection.


Indirect Contact Transmission Infection

description: Infection transmitted by water, food or other means of conveyance.


Interstitial Disease

description: A disease occurring chiefly in the connective-tissue framework of an organ.


Adolescent Gynecomastia

description: Gynecomastia that occurs during puberty and is not due to exogenous substances or disease processes.


name: Anal Canal Cancer by AJCC v6 and v7 Stage

description: A term that refers to the staging of anal canal cancer according to the American Joint Committee on Cancer, 6th and 7th editions. This staging system applies to carcinomas arising in the anal canal only; melanomas, carcinoid tumors, sarcomas, and perianal tumors are not included. (from AJCC 6th and 7th Eds.)


name: Refractory T Acute Lymphoblastic Leukemia

description: T-acute lymphoblastic leukemia that does not respond to treatment.


Metastatic Acral Lentiginous Melanoma

description: Acral lentiginous melanoma that has spread from its original site of growth to another anatomic site.


Unresectable Solid Neoplasm

description: A solid neoplasm that is not amenable to surgical resection.


name: Human Papillomavirus-Related Vaginal Adenocarcinoma

description: An adenocarcinoma that arises from the vagina and is caused by human papillomavirus infection.


name: Recurrent HIV-Related Lymphoproliferative Disorder

description: The reemergence of HIV-associated lymphoproliferative disorder after a period of remission.


name: Testicular Spermatocytic Tumor with Sarcoma

description: A malignant germ cell tumor that arises from the testis and is characterized by the presence of a spermatocytic tumor component that is contiguous with an undifferentiated or differentiated sarcomatous component.  It usually presents as a slowly growing mass that enlarges very rapidly soon after the initial diagnosis.


name: Metastatic Gastric Neuroendocrine Carcinoma

description: A gastric neuroendocrine carcinoma that has spread from its original site of growth to another anatomic site.


name: Progesterone Receptor-Positive Malignant Neoplasm

description: A malignant neoplasm that is positive for progesterone receptors.


description: Myelofibrosis that develops in a patient with history of essential thrombocythemia.


name: Locally Advanced Digestive System Carcinoma

description: Digestive system carcinoma that has spread to nearby tissues or lymph nodes.


Metastatic Benign Neoplasm

description: A very rare benign neoplasm that metastasizes inexplicably. This category includes metastasizing pleomorphic adenoma of the salivary gland and uterine corpus metastasizing leiomyoma.


name: Refractory Low Grade Fallopian Tube Serous Adenocarcinoma

description: Low grade fallopian tube serous adenocarcinoma that is resistant to treatment.


name: Refractory Malignant Urinary System Neoplasm

description: Malignant urinary system neoplasm that is resistant to treatment.


Signet Ring Melanoma

description: A rare variant of cutaneous melanoma, characterized by the presence of malignant cells with signet-ring morphology.


Junctional melanocytic nevus of skin

description: A nevus characterized by the presence of an intraepidermal proliferation of nevus cells. The nevus cells form multiple nests in the dermal-epidermal junction. It presents as a small, slightly raised, pigmented skin lesion.


Mucosal lentiginous melanoma

description: An acral lentiginous melanoma affecting mucosal surfaces.


Childhood Junctional Nevus

description: A junctional nevus that occurs during childhood.


Hypoxic-Ischemic Encephalopathy

description: Ischemic brain damage in which the entire brain is deprived of oxygen. It may be fatal or lead to long term disabilities including developmental delays, intellectual disability, and seizures.


Adult Grade III Meningioma

description: A grade III meningioma that occurs during adulthood.


Grade I Meningioma

description: A benign meningioma which may recur in approximately 7-20% of the cases.  This category includes the angiomatous meningioma, fibrous meningioma, lymphoplasmacyte-rich meningioma, meningothelial meningioma, metaplastic meningioma, microcystic meningioma, psammomatous meningioma, secretory meningioma, and transitional meningioma.


Stage II Vulvar Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Phantom Limb Syndrome

description: Paresthesia or discomfort experienced post-amputation.


Recurrent Laryngeal Nerve Paralysis

description: Paralysis of the recurrent laryngeal nerve. Causes include surgical and non-surgical traumas, neoplasms (e.g., lung carcinoma), and inflammatory neuritis.


name: Recurrent Central Nervous System Lymphoma

description: The reemergence of central nervous system lymphoma after a period of remission.


Kidney Paraganglioma

description: An extremely rare paraganglioma that arises from the renal hilum. Paragangliomas that arise from the perihilar sympathetic ganglia are not included in this category.


name: Digestive System Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the digestive system. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


name: High Grade Prostatic Intraepithelial Neoplasia, Mucinous Variant

description: High grade prostatic intraepithelial neoplasia characterized by the presence of masses of mucin within the affected distended glands.


name: Stage M0 Childhood Ependymoma by Toronto Guidelines v2

description: No visible disease on imaging (MRI brain and spine) beyond primary site of disease and no tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Malignant neoplasm of stomach recurrent

description: The reemergence of a malignant neoplasm of the stomach after a period of remission.


Stage I Cervical Cancer AJCC v8

description: Stage I includes: T1, Any N, M0. T1: Tumor confined to uterus (extension to corpus should be disregarded). M0: No distant metastasis. (AJCC 8th Ed.)


Blastic Granulocytic Sarcoma

description: A granulocytic sarcoma composed primarily of myeloblasts (WHO 2001).


Childhood NUT Carcinoma

description: A NUT carcinoma that occurs during childhood.


name: Lobular Endocervical Glandular Hyperplasia

description: Lobular proliferations of benign-appearing small to moderate sized endocervical glands in the inner half of the cervical stroma. The glands are lined by columnar epithelial cells which contain pyloric gland-type mucin. There is minimal atypia and mitotic figures are rare. Some cases have been associated with adenocarcinoma in situ/high grade cervical glandular intraepithelial neoplasia and gastric-type adenocarcinomas.


Paratesticular Serous Cystadenoma

description: A rare serous cystadenoma that arises from the paratesticular structures.


name: Clonal Cytopenia with Monocytosis of Undetermined Significance

description: A myelodysplastic/myeloproliferative neoplasm that fulfills the diagnostic criteria of clonal monocytosis of undetermined significance and is associated with cytopenia.


Stage II Pancreatic Cancer AJCC v8

description: Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Radiation-Related Osteosarcoma

description: A high grade osteosarcoma arising in an irradiated bone.


recurrent adult acute myeloid leukemia

description: The reemergence of acute myeloid leukemia in adults after a period of remission.


name: No Specific Molecular Profile Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma characterized by the absence of POLE gene mutations, mismatch repair (MMR) deficiency, and p53 gene mutations.


Pancreatic Intraductal Neoplasms

description: A group of cystic or mass-forming epithelial neoplasms that arise from the exocrine pancreas, exhibit ductal differentiation, and grow mostly within the pancreatic ducts.  This group includes the pancreatic intraductal papillary mucinous neoplasms and the pancreatic intraductal tubulopapillary neoplasms.


Great vessel abnormalities

description: A congenital vascular abnormality that affects the great vessels and/or aortic arch. Representative examples include double aortic arch, aortic coarctation, and absence of a pulmonary artery.


Stage I Appendix Carcinoma AJCC v7

description: Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Radiation-Induced Vascular Disease

description: A vascular disease caused by radiation.


name: Metastatic Sarcomatoid Urothelial Carcinoma

description: Sarcomatoid urothelial carcinoma that has spread to another anatomical site.


name: Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8

description: Stage IIIB includes: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Gangliocytoma

description: The reemergence of gangliocytoma after a period of remission.


Gallbladder Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the gallbladder. The Ki-67 index is higher than 20%.


name: Blood coagulation disorder due to liver disease

description: A disorder of blood clotting that is attributable to a deficiency in liver function.


Pathological Gynecomastia

description: Gynecomastia that is due to exogenous substances or disease processes.


Pedunculated conjunctival papilloma

description: A papilloma that arises from the conjunctival squamous epithelium. It is associated with human papillomavirus infection.


Benign Intracranial Neoplasm

description: A neoplasm that involves the intracranial area and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Clinical Stage IVB Esophageal Adenocarcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Chronic Insomnia

description: Insomnia that has persisted at least one month.


New Onset Diabetes After Transplant

description: Development of diabetes after transplant, usually associated with calcineurin inhibitor use.


Localized Prostate Carcinoma

description: A carcinoma that arises from the prostate and has not spread to other anatomic sites.


name: Benign Ovarian Partly Luteinized Thecoma


name: Metastatic Malignant Nongerminomatous Germ Cell Tumor

description: A malignant nongerminomatous germ cell tumor that has spread from its original site of growth to another anatomic site.


Recurrent Meningioma

description: The reemergence of a meningioma after a period of remission.


Well Differentiated Malignant Neoplasm

description: A malignant neoplasm with morphological features reminiscent of the tissue from which it arose.


name: Ampulla of Vater Neuroendocrine Neoplasm

description: A neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and periampullary region. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


Ovarian Leydig Cell Hyperplasia

description: An increased number of Leydig cells in the hilar region of the ovary. (WHO 2020)


Stage IV Merkel Cell Carcinoma AJCC v7

description: Stage IV includes: Any T, Any N, M1.  M1: Metastasis beyond regional lymph nodes. (AJCC 7th Ed.)


Stage 0 Anal Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: High-grade squamous intraepithelial lesion (previously termed carcinoma in situ, Bowen disease, anal intraepithelial neoplasia II-III, high-grade anal intraepithelial neoplasia). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Endometrial Carcinoma

description: A carcinoma that arises from the endometrium and has metastasized to another anatomic site.


name: Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma


Digestive System Hodgkin Lymphoma

description: A Hodgkin lymphoma that arises from any part of the digestive system, with the bulk of the disease localized to that site.


Refractory Skin Squamous Cell Carcinoma

description: Skin squamous cell carcinoma that does not respond to treatment.


name: Simple Hamartoma of the Retinal Pigment Epithelium

description: A retinal hamartoma that involves only the retinal pigment epithelium. (WHO 2018)


Acute Myeloid Leukemia with del(17p)

description: Acute myeloid leukemia associated with deletion of the short arm of chromosome 17 [del(17p)].


mCode Non-Neoplastic Disease/Finding

description: Terminology related to non-neoplastic diseases and findings that was developed to support the efforts of Minimal Common Oncology Data Elements (mCode), a data standard designed to increase high-quality data for all cancer types.


name: Extragonadal primary germ cell tumor mixed stage II


Refractory Myxoid Liposarcoma

description: Myxoid liposarcoma that does not respond to treatment.


name: Esophageal Adenocarcinoma by AJCC v7 Stage

description: A term that refers to the staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 7th edition.


Subcutaneous Disorder

description: A disorder of the subcutaneous tissue.


name: Undersocialized conduct disorder, aggressive type


name: Locally Advanced Biliary Tract Carcinoma

description: Carcinoma that arises from the intrahepatic, hilar, extrahepatic bile ducts, cystic duct, or gallbladder and has spread to nearby tissues or lymph nodes.


name: Refractory Endometrial Transitional Cell Carcinoma

description: Endometrial transitional cell carcinoma that is resistant to treatment.


Recurrent Appendix Carcinoma

description: The reemergence of appendix carcinoma after a period of remission.


Kidney Schwannoma

description: A rare schwannoma arising from the kidney.


Childhood Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that occurs during childhood.


Congenital complete heart block

description: A disorder characterized by an electrocardiographic finding of a complete atrioventricular block that manifests during fetal life or soon after birth. It may be isolated or associated with other congenital heart defects. Isolated congenital complete atrioventricular block may be associated with maternal connective tissue disorders.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 2

description: Dyskeratosis congenita caused by mutation(s) in the TERT gene, encoding telomerase reverse transcriptase.


name: Appendix Neuroendocrine Tumor by AJCC v7 Stage

description: A term that refers to the staging of an appendiceal neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system.


name: Lugano Classification Stage IE Childhood Hodgkin Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Metaplastic meningioma

description: A WHO grade I meningioma characterized by the presence of a prominent mesenchymal component. The mesenchymal component may be osseous, cartilaginous, myxoid, lipomatous, or a mixture of mesenchymal elements.


name: Postneoadjuvant Therapy Stage IVA Esophageal Adenocarcinoma AJCC v8

description: Stage IVA includes: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Stage IV Bone Cancer AJCC v7

description: Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Childhood Blue Nevus

description: A blue nevus that occurs during childhood.


Joint Tuberculosis

description: Tuberculosis affecting a joint.


Ureter Cancer by AJCC v7 Stage

description: A term that refers to the staging of ureter cancer according to the American Joint Committee on Cancer, 7th edition.


Foregut Neuroendocrine Tumor G1

description: A neuroendocrine tumor that arises from the esophagus, stomach, or duodenum.


Stage IIIA Gallbladder Cancer AJCC v7

description: Stage IIIA includes: T3, N0, M0. T3: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Polycythaemia (excl rubra vera)

description: An increase in the concentration of red blood cells (hemoglobin) that is not caused by polycythemia vera.