A member of the class of quinolones that is the amide obtained from formal condensation of the carboxy group of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid with the amino group of 2-amino-3-methyl-1,3-thiazole.


prilocaine

An  amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.


bictegravir

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid with the amino group of 2,4,6-trifluorobenzylamine. It is a second-generation integrase strand transfer inhibitor (INSTI) and used (as its sodium salt) for the treatment of HIV-1.


A primary fatty amide resulting from the formal condensation of the carboxy group of (12Z)-octadecenoic acid with ammonia.


valpromide

A fatty amide derived from valproic acid.


N-icosanoyltaurine

A fatty acid-taurine conjugate derived from icosanoic acid.


A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 2-[4-fluoro-3-(trifluoromethyl)phenoxy]butyric acid with the amino group of benzylamine.


dacarbazine

A dacarbazine in which the N=N double bond adopts a trans-configuration.


N,N-dimethylacetamide

A member of the class of  acetamides that is  acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism.


OLEIC ACID ANILIDE

The fatty amide resulting from the formal condensation of oleic acid and aniline.


(S)-beflubutamid

An N-benzyl-2-[4-fluoro-3-(trifluoromethyl)phenoxy]butanamide that has S configuration.


N-(butanoyl)ethanolamine

An N-(saturated fatty acyl)ethanolamine that is the ethanolamide of butanoic acid.


An azo dye with a structure consisting of acetanilide substituted on the 4-position of the phenyl group with a 6-hydroxy-m-tolylazo group.


N-acetylneuraminamide

The monocarboxylic acid amide formed from N-acetylneuraminic acid.


N-acylethanolamine 22:6

A N-(long-chain-acyl)ethanolamine in which the acyl group contains 22 carbons and 6 double bonds.


A 1,3-thiazole in which the only substituent is an aminocarbonyl group at position 5.


name: (2E,4E)-2-methyl-hexa-2,4-dienoic acid (2'R,3'S)-allo-isoleucinol amide


CLINOLAMIDE

The amide obtained by formal condensation of linoleic acid with cyclohexylamine.


A member of the class of bipyridines that is 4,4'-bipyridine substituted at positions 2 and 2' by 4-fluoroaminophenyl and 4-methoxycyclohexanecarboxamido groups respectively.


N-acylethanolamine 20:3

A N-(long-chain-acyl)ethanolamine in which the acyl group contains 20 carbons and 3 double bonds.


METHYL ISOTHIOCYANATE

A monocarboxylic acid amide that is dacarbazine in which one of the methyl groups is replaced by a hydrogen. It is the active metabolite of dacarbazine, and is also produced by spontaneous hydrolysis of temozolomide in the body.


nepafenac

A monocarboxylic acid amide that is amfenac in which the carboxylic acid group has been converted into the corresponding carboxamide. It is a prodrug for amfenac, used in eye drops to treat pain and inflammation following cataract surgery.


MYXOTHIAZOL

A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S,3E,5E)-7-methylocta-3,5-dien-2-yl group. It is an inhibitor of coenzyme Q - cytochrome c reductase.


butanamides

A fatty amide derived based on a butanamide skeleton and its substituted derivatives.


A secondary carboxamide resulting from the formal condensation of the carboxy group of N-(naphthalen-1-ylcarbonyl)glycine with the amino group of 2-(3-methoxyphenoxy)aniline. It is a first-in-class small molecule inhibitor of PCNA, a protein essential for DNA replication and repair within tumours.


(S)-napropamide

The (S)-enantiomer of N,N-diethyl-2-(naphthalen-1-yloxy)propanamide.


A cysteine derivative obtained by formal condensation between N-butyl-L-cysteinamide and 2-thienylacetic acid.


ARACHIDONAMIDE

A primary fatty amide resulting from the formal condensation of the carboxy group of arachidonic acid with ammonia.


ergometrine

A monocarboxylic acid amide that  is lysergamide in which one of the hydrogens attached to the amide nitrogen is substituted by a 1-hydroxypropan-2-yl group (S-configuration). An ergot alkaloid that has a particularly powerful action on the uterus, its maleate (and formerly tartrate) salt is used in the active management of the third stage of labour, and to prevent or treat postpartum of postabortal haemorrhage caused by uterine atony: by maintaining uterine contraction and tone, blood vessels in the uterine wall are compressed and blood flow reduced.


A L-serine derivative obtained by formal condensation between N-butyl-L-serinamide and (R)-2-hydroxy-2-phenylacetic acid.


linoleylanilide

A fatty amide conjugate of linoleic acid and aniline.


TETRADECANAMIDE

A fatty amide of myristic acid.


N-(saturated fatty acyl)ethanolamine

Any N-acylethanolamine in which the acyl group is derived from a saturated fatty acid.


A primary fatty amide resulting from the formal condensation of the carboxy group of (7Z)-octadecenoic acid with ammonia.


Isatin bearing a 6-aminohexanamido group at C-5.


N-(dodecanoyl)ethanolamine

An N-(long-chain-acyl)ethanolamine resulting from the formal condensation of the carboxy group of dodecanoic acid (myristic acid) with the amino group of ethanolamine.


An  aromatic amide that is purine bearing a carboxamido substituent at position 6.


oleamide

A fatty amide derived from oleic acid.


LINOLEOYLETHANOLAMIDE

An N-acylethanolamine 18:2 that is the ethanolamide of linoleic acid.


carcinine

A beta-alanine derivative that is the amide obtained by formal condensation of the carboxy group of beta-alanine with the primary amino group of histamine.


A fatty amide obtained by the formal condensation of (11Z,14Z)-eicosadienoic acid with ethanolamine.


N-acetylethanolamine

A member of the class of ethanolamines that is 2-aminoethanol in which one of the hydrogens of the amino group is replaced by an acetyl group.


mirabegron

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-amino-1,3-thiazol-4-ylacetic acid with the anilino group of (1R)-2-{[2-(4-aminophenyl)ethyl]amino}-1-phenylethanol. Used for the treatment of overactive bladder syndrome.


OCTADECANOIC ACID AMIDE

A fatty amide of stearic acid.


name: N-Ethyl N-(2-hydroxy-ethyl) arachidonoyl amine


granisetron

A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 1-methyl-1H-indazole-3-carboxylic acid with the primary amino group of (3-endo)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine. A selective 5-HT3 receptor antagonist, it is used (generally as the monohydrochloride salt) to manage nausea and vomiting caused by cancer chemotherapy and radiotherapy, and to prevent and treat postoperative nausea and vomiting.


A member of the class of quinolones that is the amide obtained from formal condensation of the carboxy group of 4-hydroxy-1-isopentyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid with the amino group of 2-amino-3-methyl-1,3-thiazole.


arenecarboxamide

A monocarboxylic acid amide in which the amide linkage is bonded directly to an arene ring system.


A fatty acid-taurine conjugate derived from N-[12(S)-hydroperoxy-(5Z,8Z,10E,14Z)]-icosatetraenoic acid.


name: methoxyiminoacetamide strobilurin antifungal agent

description: Any strobilurin antifungal agent that contains a methoxyiminoacetamide group, RC(=NOMe)C(=O)NHMe.


2-naphthol AS BI-beta-D-glucuronide

A beta-D-glucosiduronic acid having a 6-bromo-3-[(2-methoxyphenyl)carbamoyl]naphthalen-2-yl substituent at the anomeric position.


linoleamide

A fatty amide obtained from  linoleic acid.


N-purin-6-oyl-epsilon-aminocaproic acid

A purine derivative that consists of 6-aminohexanoic acid having a purin-6-oyl group attached to the amino function via an amide bond.


A cysteine derivative obtained by formal condensation between N-butyl-L-cysteinamide and (R)-2-hydroxy-2-phenylacetic acid.


(R)-beflubutamid

An N-benzyl-2-[4-fluoro-3-(trifluoromethyl)phenoxy]butanamide that has R configuration.


LINOLENAMIDE

A fatty amide resulting from the formal condensation of the carboxy group of alpha-linolenic acid with ammonia.


A fatty acid-taurine conjugate derived from N-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)]-icosatetraenoic acid.


tocainide

A monocarboxylic acid amide in which 2,6-dimethylphenylaniline and isobutyric acid have combined to form the amide bond; used as a local anaesthetic.


A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(dimethylamino)pentanoic acid with the aromatic amino group of N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide.


N-octylhomovanillamide

A monocarboxylic acid amide that is the N-octyl amide of homovanillic acid.


esatenolol

The (S)-enantiomer of atenolol.


hydroperoxy fatty amide

Any fatty amide carrying one or more hydroperoxy substituents.


SEA

An N-acylethanolamine 18:0 that is the ethanolamide of octadecanoic acid.


A glycohexaosylceramide having alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-alpha-D-GalNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycohexaosyl component.


A glycoheptaosylceramide having a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc component attached to the primary hydroxy function of a ceramide with undefined sphingoid base and fatty acyl chain.


A glycododecaosylceramide having an alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc component attached to the primary hydroxy function of a ceramide with d18:1 sphingoid base and undefined fatty acyl chain.


A ten-membered fucosyl oligoglycosylceramide having alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the oligoglycosyl component.


A glycooctaosylceramide in which the sugar component is a linear heptasaccharide comprised of fucose, galactose, N-acetylgalactosamine, glucose and N-acetylglucosamine residues, branched with an extra L-fucosyl residue at one of the central galactose residues within the chain.


A glycoheptaosylceramide having alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycoheptaosyl component.


beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer in which the sphingoid base is (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl.


A glycohexaosylceramide having alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc as the glycohexaosyl component.


A glycoheptaosylceramide having alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycoheptaosyl component.


A glycopentaosylceramide having alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycopentaosyl component.


A glycopentaosylceramide having alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc as the glycopentaosyl component.


A glycohexaosylceramide having alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycohexaosyl component.


A branched glycopentaosylceramide having a beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glccomponent attached to the primary hydroxy function of a ceramide with undefined sphingoid base and fatty acyl chain.


A branched glycooctaosylceramide having alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the octaosyl portion.


A glycoheptaosylceramide having a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc component attached to the primary hydroxy function of a ceramide with d18:1 sphingoid base and and undefined fatty acyl chain.


A glycoheptaosylceramide having a beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc component attached to the primary hydroxy function of a ceramide with undefined sphingoid base and fatty acyl chain.


A glycohexaosylceramide having an alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc component attached to the primary hydroxy function of a ceramide with undefined sphingoid base and fatty acyl chain.


A glycooctaosylceramide having beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycooctaosyl component


A glycopentaosylceramide having beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl component attached to the primary hydroxy function of a ceramide with undefined sphingoid base.


A glycoheptaosylceramide having N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl as the glycoheptaosyl component.


A glycononaosylceramide consisting of a branched nonasaccharide made up from four galactose residues, three N-acetylglucosamine residues, one fucosyl residue and one glucose residue, which at the reducing end is attached to the ceramide portion via a beta-linkage.


A glycotetraosylceramide having N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl as the glycotetraosyl component.


A glycononaosylceramide in which the sugar component is a linear heptasaccharide made up from galactose, N-acetylgalactosamine, glucose and N-acetylglucosamine residues, branched with L-fucosyl residues at two of the galactose residues in the chain.


A glycoheptaosylceramide having alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycoheptaosyl component.


A glycopentaosylceramide having alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl component attached to the primary hydroxy function of a ceramide with undefined sphingoid base.


A glycohexaosylceramide having alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycohexaosyl component.


A glycooctaosylceramide having an alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc component attached to the primary hydroxy function of a ceramide with d18:1 sphingoid base and undefined fatty acyl chain.


A glycopentaosylceramide having alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycopentaosyl component.


A glycopentaosylceramide having a beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc component attached to the primary hydroxy function of a ceramide with d18:1 sphingoid base and and undefined fatty acyl chain.


A branched glycohexaosylceramide having  alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycohexaosyl portion.


A glycoheptaosylceramide having N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl as the glycoheptaosyl component.


A glycohexaosylceramide having alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycohexaosyl component.


A glycododecaosylceramide having alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-[alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the dodecasaccharide component.


A glycooctaosylceramide having alpha-D-GalNAc-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycooctaosyl component


A glycohexaosylceramide having alpha-D-GalNAc-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycohexaosyl component.


A  branched glycopentaosylceramide having alpha-L-fucosyl-(1->3)-[beta-D-galactosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucose as the glycopentaosyl portion.


pentitol derivative

An alditol derivative that is formally obtained from a pentitol.


stachyose

A tetrasaccharide consisting of sucrose having an alpha-D-galactosyl-(1->6)-alpha-D-galactosyl moiety attached at the 6-position of the glucose.


CoA ester of bhos#30


platinum copper nanoparticle

A bimetallic nanoparticle consisting of platinum and copper atoms.


cob(II)yrinic acid

A cobalt-corrinoid heptacarboxylic acid with 8 methyl groups at positions 1, 2, 5, 7, 12, 15, 17; -CH2COOH groups at positions 2, 7, 18; -CH2CH2COOH groups at positions 3, 8, 13, 17; and divalent cobalt centred among the four nitrogens. It is a part of the vitamin B12 structure.


hexaamminecobalt(III) chloride

A cobalt coordination entity consisting of a hexaamminecobalt(III) cation in association with three chloride anions as counterions.


cobalt(II)-factor III

A metalloporphyrin obtained by formal dehydrogenation across positions 7 and 8 of cobalt-precorrin-3.


adenosylcobyric acid

A cobalt corrinoid that is cobyric acid having a 5'-adenosyl group attached to the central cobalt atom.


cobamide

A cobalt-corrinoid hexaamide that is the parent compound of the class of cobamides.


adenosylcobyrate

A cobalt corrinoid that is the conjugate base of adenosylcobyric acid, obtained by deprotonation of the carboxy group.


cobalamin

A cobalt-corrinoid hexaamide that is cobalamin with the oxidation state of the central cobalt atom unspecified.


adenosylcobinamide

A cobalt-corrinoid hexaamide comprising cobinamide having an adenosyl group attached to cobalt.


cobalt dinitrate

A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is nitrate.


elemental cobalt

An element in the cobalt group of the periodic table with atomic number 27, atomic mass 58.933, M.P. 1495 C, and B.P. 2927 C.


Cobamide in which 5-hydroxy-1H-benzimidazole is attached by a glycosyl link from its N-1 to the C-1 of the ribose moiety.


cob(I)alamin

A cobalamin in which the central cobalt atom has an oxidation state of +1.


cobalt(II) acetate

A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is acetate.


cobalt(II) bis(acetylacetonate)

A cobalt coordination entity in which two molecules of 2,4-dioxopentan-3-ide form a coordination complex with cobalt(2+).


cob(II)yrinic acid c monoamide

A cobalt corrinoid obtained via amidation of the carboxy group at position c of cob(II)yrinic acid.


adenosylcob(III)yrinic acid a,c-diamide

A cobalt corrinoid that is cob(III)yrinic acid a,c-diamide having a 5'-adenosyl group attached to the central cobalt atom.


A cobalt corrinoid that is precorrin-8 in which the four pyrrole-type nitrogens are bound to a central cobalt atom.


A cobalt coordination entity that is methane in which one of the hydrogens is replaced by cobalt(2+)


heptitol derivative

An alditol derivative that is formally obtained from a heptitol.


N-hydroxyimidothioate

An imidothioate in which the nitrogen is substituted by a hydroxy group.


An S-substituted glutathione in which the thiol hydrogen of glutathoine has been replaced by a 6-methylthiohexylhydroximoyl group.


A glutathione conjugate in which the mercapto hydrogen of glutathione has been replaced by an N-hydroxy-2-(indol-3-yl)ethanimidoyl group.


A glutathione conjugate in which the mercapto hydrogen of glutathione has been replaced by an N-hydroxy-2-phenylethanimidoyl group.


A branched tetrasaccharide derivative consisting of a linear trisaccharide unit of beta-L-rhamnose, beta-D-glucose and N-acetyl-beta-D-galactosamine residues linked sequentially (1->4) and (1->3), to the N-acetylgalactosamine residue of which is also linked (1->4) an alpha-L-rhamnosyl residue, the whole linked glycosidically to a 5-aminopentyl group.


A bromophenol that is phenol in which the hydrogens at positions 2 and 4 have been replaced by bromines.


An organic cation obtained by protonation of the imidazole group of (S)-eberconazole.


An O-(S-acylpantetheine-4'-phosphoryl)-L-serine(1-) residue in which the S-acyl group is specified as (3R)-hydroxy-(5Z)-dodecenoyl; major species at pH 7.3.


(R)-salsolinol

A 1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol that has R-configuration.


b-D-GALACTOSE

A D-galactopyranose having beta configuration at the anomeric centre.


name: 8-Prenylkaempferol 4'-methyl ether 3-rhamnosyl-(1->6)-galactoside-7-galactoside


A linear amino trisaccharide consisting of three N-acetyl-beta-D-galactosamine residues linked (1->4).


A 1,2-diacyl-sn-glycero-3-phosphoethanolamine zwitterion in which the acyl groups at C-1 and C-2 contain 37 carbons in total with 3 double bonds.


cepham

An organic heterobicyclic compound that consists of (6R)-5-thia-1-azabicyclo[4.2.0]octane bearing an 8-keto substituent. The parent of the class of cephams.


A 2-amino-4-hydroxypteridine carrying two additional methyl substituents at positions 6 and 7.


Any pteridine carrying amino and hydroxy substituents at positions 2 and 4 respectively.


An amino disaccharide consisting of beta-D-Galp joined by a (1->4) glycosidic bond to 2-acetamido-2-deoxy-alpha-D-glucopranose.


DEMETHYLSUBEROSIN

A hydroxycoumarin that is 7-hydroxycoumarin which is substituted at position 6 by a 3-methylbut-2-en-1-yl group. A natural product found in Citropsis articulata.


naphthols

Any hydroxynaphthalene derivative that has a single hydroxy substituent.


DYNASORE

A carbohydrazide resulting from the formal condensation of the hydrazone moiety of 3,4-dihydroxybenzaldehyde hydrazone with the carboxy group of 3-hydroxy-2-naphthoic acid. It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity of dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42.


Oil red O

A bis(azo) compound that is 2-naphthol substituted at position 1 by a {4-[(2,5-dimethylphenyl)diazenyl]-2,5-dimethylphenyl}diazenyl group. A fat-soluble dye predominantly used for demonstrating triglycerides in frozen sections and for staining of protein bound lipids in paraffin sections.


A naphthol carrying a hydroxy group at position 1.


ANCISTROTANZANINE A

An isoquinoline alkaloid that is (3S)-6,8-dimethoxy-1,3-dimethyl-3,4-dihydroisoquinoline substituted by a 1-hydroxy-8-methoxy-3-methylnaphthalen-2-yl group at position 5. It is isolated from the leaves of Ancistrocladus tanzaniensis and exhibits antiplasmodial, antileishmanial and antitrypanocidal activities.


A naphthol in which the hydroxy substituent is at C-1 with nitro groups at C-2 and -4.


michellamine A

A dimeric isoquinoline alkaloid isolated from Ancistrocladus abbreviatus and has been shown to exhibit anti-HIV activity.


Sudan IV

A bis(azo) compound that is 2-naphthol substituted at position 1 by a {2-methyl-4-[(2-methylphenyl)diazenyl]phenyl}diazenyl group. A fat-soluble dye predominantly used for demonstrating triglycerides in frozen sections, but which may also stain some protein bound lipids in paraffin sections.


betanaphthol

A naphthol carrying a hydroxy group at position 2.


A member of the class of naphthols that is 2-naphthol carrying an additional bromo substituent at position 6.


DIONCOPHYLLINE C

An isoquinoline alkaloid that is the biaryl resulting from substitution of the hydrogen at the 5-position of (1R,3R)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-8-ol by a 5-hydroxy-4-methoxy-2-methylnaphthalen-1-yl group. It is a naphthylisoquinoline alkaloid isolated from the roots and stem barks of Triphyophyllum peltatum and exhibits antimalarial activity.


naphthol

A member of the class of naphthols carrying a single hydroxy substituent at C-1 or C-2. A closed class.


A dipeptide zwitterion resulting from transfer of a proton from the carboxy to the amino group of S-[(E)-N-hydroxy-2-(indol-3-yl)ethanimidoyl]-L-cysteinylglycine; major species at pH 7.3.


An amino disaccharide consisting of a beta-D-galactopyranose residue and a 2-acetamido-2-deoxy-beta-D-galactopyranose residue joined in sequence by a (1->6) glycosidic bond.


The univalent carboacyl group formed by loss of -OH from the carboxy group of 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid.


An O-(S-3-oxoacylpantetheine-4'-phosphoryl)-L-serine(1-) residue in which the S-acyl group is specified as (9Z,21Z)-3-oxotetracontadienoyl.


ergosine

An  ergot alkaloid isolated from the fungus Epichloe typhina.


primaquine

An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.


4-(methylsulfanyl)butanal oxime

An aliphatic aldoxime resulting from the formal condensation of 4-(methylsulfanyl)butanal with hydroxylamine.


L-idose

The L-stereoisomer of idose.


alpha-L-idopyranose

The alpha-anomer of L-idopyranose.


L-idopyranose

The pyranose form of L-idose.


L-idofuranose

The furanose form of L-idose.


beta-L-idofuranose

L-idofuranose in which the carbon bearing the anomeric hydroxy group has beta configuration.


beta-L-idopyranose

The beta-anomer of L-idopyranose.


aldehydo-L-idose

The open chain form of L-idose.


alpha-L-idofuranose

An L-idofuranose that has alpha configuration at the carbon bearing the anomeric hydroxy group.


Phe-Val-Asp

A tripeptide composed of L-phenylalanine, L-valine, and L-aspartic acid joined by peptide linkages.


An amino disaccharide consisting at the non-reducing end of a beta-D-galactosyl residue joined through a (1->3) glycosidic linkage to N-acetyl-6-O-sulfo-beta-D-galactose.


ER 27319 maleate

ER 27319 maleate is a selective inhibitor of Syk kinase.


An organic anionic group obtained by deprotonation of the terminal carboxy group of C-terminal L-Cys-L-Leu-L-Val-L-Cys residue.


6-hydroxyferuloyl hexose hexoside

R1=hexoside,R2=H; or R1=H,R2=hexoside; R3=hexoside


orinapterin

A biopterin that consists of pterin bearing amino, oxo and 1,2-dihydroxypropyl substituents at positions 2, 4 and 6.


An L-cysteine derivative in which the sulfur atom carries a 1,4-dihydroxynonan-3-yl substituent. It has been synthesised by reaction of (E)-4-hydroxynon-2-enal (HNE) with L-cysteine, the sulfur atom of cysteine reacting with the double bond function of HNE via formation of a Michael adduct.


levofolinic acid

The pharmacologically active (6S)-stereoisomer of 5-formyltetrahydrofolic acid.


An amino trisaccharide in which an alpha-L-fucosyl-(1->2)-D-galactosyl unit is linked (1->3) to a 6-sulfated N-acetyl-beta-D-glucosamine residue.


primary carboxamide

A carboxamide resulting from the formal condensation of a carboxylic acid with ammonia; formula RC(=O)NH2.


cefsulodin

A pyridinium-substituted semi-synthetic, broad-spectrum, cephalosporin antibiotic.


aliphatic primary amide

A primary carboxamide in which the amide linkage is bonded directly to an aliphatic system.


cellocidin

A dicarboxylic acid diamide resulting from the formal condensation of both of the carboxy groups of butynedioic acid with ammonia. An antibacterial agent produced by Streptomyces chibaensis.


ENT-ZWITTERMICIN A

The (-)-enantiomer of zwittermicin A.


A member of the class of naphthalenes that is naphthalene which is substituted by a 2-amino-2-oxoethyl group at position 1. It is a synthetic auxin that is widely used in agriculture to promote the growth of numerous fruits, for root cuttings and as a fruit thinning agent.


(+)-zwittermicin A

The (+)-enantiomer of zwittermicin A. It is a water-soluble natural antibiotic from the fermentation of the soil-borne bacterium Bacillus cereus and shows significant activity against phytopathogenic fungi.


agrocybin

A triyne amide produced by the Brazilian fungus Agrocybe perfecta (Basidiomycota).


An L-alpha-amino acid residue derived from O(3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonine.


chromium carbene

An organochromium compound containing a carbon-chromium double bond.


azobenzene

A molecule whose structure comprises two phenyl rings linked by a N=N double bond; the parent compound of the azobenzene class of compounds.


(Z)-azobenzene

The (Z)-isomer of azobenzene.


AZOBENZENE

The (E)-isomer of azobenzene.


name: 4-[(2,5-dihydroxyphenyl)methylamino]benzoic acid methyl ester


MONO-N-ACETYL DAPSONE

A secondary carboxamide resulting from acetylation of one of the amino groups of dapsone.


An organic cation that is phenothiazin-5-ium substituted by amino and dimethylamino groups at positions 3 and 7 respectively. The chloride salt is the histological dye 'azure A'.


rac-lisofylline

A racemate comprising equal amounts of (R)- and (S)-lisofylline. It is a metabolite of pentoxifylline and a potent anti-inflammatory agent in which the (-)-isomer is biologically active.


DIZOCILPINE MALEATE

A maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid.


A branched amino oligosaccharide that is a henicosasaccharide derivative consisting of a linear trisaccharide of beta-D-mannose and two N-acetyl-beta-D-glucosamine residues (one of which is at the reducing end) all linked in sequence (1->4), to the mannosyl residue of which are linked (1->3) and (1->6) two beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl linear nonasaccharide units.


An alpha-D-Galp-(1->6)-D-Galp in which the carbon bearing the anomeric hydroxy group has alpha configuration.


A member of the class of nitrotoluenes that is ortho-nitrotoluene bearing two additional hydroxylamino substituents located at the two positions meta to the nitro group.


5,5-dimethyl-1-pyrroline N-oxide

A member of the class of 1-pyrroline nitrones (1-pyrroline N-oxides) resulting from the formal N-oxidation of 5,5-dimethyl-1-pyrroline. Used as a spin trap for the study of radicals formed by enzymatic acetaldehyde oxidation.


allaric acid derivative

A hexaric acid derivative that is formally obtained from allaric acid.


A class of glycoglycerolipids that consists of any 1,2-diacyl-sn-glycerol having an (alpha-D-galactopyranosyl)-(1->2)-(alpha-D-glucopyranosyl) glycosyl moiety attached at position 3.


reticulinylium

A benzylisoquinoline alkaloid that is obtained by selective dehydrogenation at the 1,2-position of reticuline.


Any glycosyloxyflavone that consists of a flavonol attached to a xylosylglycosyl residue at position 3 via a glycosidic linkage.


An amino acid zwitterion of N(alpha),N(alpha)-dimethyl-L-histidine having an anionic carboxy group and a protonated amino group.


porfimer

The sodium salt of porfimer. The purified component of haematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins formed by ether and ester linkages of up to eight porphyrin units (n = 0-6), where R = CH(OH)Me and/or CH=CH2. After addition of hydrochloric acid and/or sodium hydroxide to pH 7.2 - 7.9, it is used as a photosensitiser in photodynamic therapy of non-small cell lung cancer, oesophageal cancer, and superficial bladder cancer. The drug is administered by slow intravenous injection and accumulates in malignant tissue. After 40-50 hours, it is activated by laser light at 630 nm, delivered to the tumour using a fibre optic guide. Subsequent spin transfer to oxygen molecules within the tissue, generates highly reactive singlet oxygen, and subsequent radical reactions generate superoxide and hydroxyl radicals. Propagation of radical reactions ultimately kills the tumour cells.


Qdot 585

A quantum dot fluorescent dye with an emission wavelength of 585 nm.


3-hydroxy-L-proline residue

An L-proline residue that is substituted by an hydroxy group at position 3.


clobenpropit dihydrobromide

A hydrobromide salt obtained by reaction of clobenpropit with two equivalents of hydrobromic acid. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.


4,5,5'-trihydroxy-L-leucine residue

An L-leucine residue that is substituted by hydroxy groups at positions 4, 5 and 5'.


Phe-Gly-Gly

A tripeptide composed of one L-phenylalanine and two glycine residues joined in sequence.


SODIUM BISULFITE

An inorganic sodium salt having hydrogensulfite as the counterion.


SODIUM SULFITE

An inorganic sodium salt having sulfite as the counterion.


glyciniumyl group

The organic cationic group formed from glycinium; the major structure at pH 7.3 of the glycyl group, formed by protonation of the amino group.


isoscutellarein glycoside

A C-glycosyl compound that is isoscutellarein attached to a  beta-D-glucopyranosyl moiety at position 6 via a C-glycosidic linkage. Isolated from the rhizomes of Iris pseudopumila, it exhibits antioxidant activity.


A deoxyallose that is beta-D-allopyranose in which the hydroxy group at position 6 has been replaced by a hydrogen.


methylbimane

A pyrazolopyrazole that consists of 1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione bearing four methyl substituents at positions 2, 3, 5 and 6.


europium-151 atom

The stable isotope of europium with relative atomic mass 150.919846, 47.8 atom percent natural abundance and nuclear spin 5/2.


cyclosporin A metabolite M13

A cyclosporin A derivative that is cyclosporin A in which the residue-9 N-methylleucine moiety has undergone oxidation so as to introduce a hydroxy group at the carbon bearing the two methyl groups, while the residue-4 N-methylleucine moiety has undergone N-demethylation.


cyclosporin A metabolite M1

A cyclosporin A derivative that is cyclosporin A in which residue 9 (N-methylleucine) has undergone oxidation so a to introduce a hydroxy group at the carbon bearing the two methyl groups.


cyclosporin A metabolite M9

A cyclosporin A derivative that is cyclosporin A in which the N-methylleucine residues at positions 6 and 9 have both undergone oxidation by hydroxylation at the carbon bearing the two methyl groups, and in which while the N-methylleucine residue at position 4 has undergone N-demethylation.


cyclosporin A hydrogen sulfate

A cyclosporin A derivative that is cyclosporin A  in which the hydroxy group at the MeBmt (butenylmethylthreonine) amino acid is replaced by a sulfooxy group.


cyclosporin A metabolite M10

A cyclosporin A derivative that is cyclosporin A in which residues 4 and 9 (both N-methylleucine) have undergone oxidation so as to introduce a hydroxy group at position 4 (the carbon bearing the two methyl groups) in each case.


cyclosporin A metabolite M17

A cyclosporin A derivative that is cyclosporin A in which residue 1 [(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoic acid] has undergone allylic oxidation to give the corresponding primary allylic alcohol. It specifically inhibits growth of renal cells in culture.


cyclosporin A metabolite M25

A cyclosporin A derivative that is cyclosporin A in which residue 1 [(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoic acid] has undergone allylic oxidation to give the corresponding primary allylic alcohol, while residue 4, N-methylleucine, has undergone N-demethylation.


cyclosporin A metabolite M16

A cyclosporin A derivative that is cyclosporin A in which residues 6 and 9 (both N-methylleucine) have undergone oxidation so a to introduce a hydroxy group at position 4 (the carbon bearing the two methyl groups) in each case.


cyclosporin A metabolite M21

A cyclosporin A derivative that is cyclosporin A in which residue 4 (N-methylleucine) has undergone N-demethylation.


cyclosporin A metabolite M8

A cyclosporin A derivative that is cyclosporin A in which residue 1 [(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoic acid] has undergone allylic oxidation to give the corresponding primary allylic alcohol, and in which residue 9 (N-methylleucine) has undergone oxidation so as to introduce a hydroxy group at the carbon bearing the two methyl groups.


monohydroxyquinoline

A hydroxyquinoline carrying a single hydroxy substituent.


A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 6.


2-heptyl-4-hydroxyquinoline N-oxide

An inhibitor of the mitochondrial respiratory chain at cytochrome bc1 and of photosynthetic electron flow immediately before cytochrome b559.


8-hydroxyquinoline N-oxide

A quinoline N-oxide carrying a hydroxy substituent at position 8.


indacaterol

A monohydroxyquinoline that consists of 5-[(1R)-2-amino-1-hydroxyethyl]-8-hydroxyquinolin-2-one having a 5,6-diethylindan-2-yl group attached to the amino function. Used as the maleate salt for treatment of chronic obstructive pulmonary disease.


A heterodetic cyclic peptide that is biosynthesised by an engineered strain of Escherichia coli


A monohydroxyquinoline carrying a hydroxy substituent at position 7.


A quinoline having the keto group at the 4-position and an additional hydroxy substituent at the 3-position.


oxyquinoline

A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.


A monohydroxyquinoline carrying a hydroxy group at position 4.


A monohydroxyquinoline that is 6-hydroxyquinoline in which the hydrogen at position 2 is replaced by a phenoxy group.


A monohydroxyquinoline that is 4-hydroxyquinoline bearing an additional heptyl substituent at position 2.


An amino pentasaccharide consisting of 2-acetamido-2-deoxy-alpha-D-galactopyranosyl, beta-D-galactopyranosyl, 2-acetamido-2-deoxy-beta-D-glucopyranosyl, beta-D-galactopyranosyl and D-glucopyranose residues joined in sequence by (1->3), (1->3), (1->3) and (1->4) glycosidic bonds.


kaempferol 3-beta-gentiobioside

A kaempferol O-glucoside in which the hydroxy hydrogen at position 3 of kaempferol has been replaced by a gentiobiosyl group.


A branched amino pentasaccharide consisting of the trisaccharide beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactose where the galactosyl residue at the non-reducing end has alpha-L-fucosyl and N-acetyl-alpha-D-galactosaminyl residues attached at the 2- and 3-positions respectively and the glucosaminyl residue has an alpha-L-fucosyl residue attached at the 4-position.


diazaborine

A organonitrogen heterocyclic compound consisting of 2,3,1-benzodiazaborinine substituted at positions 1 and 2 by hydroxy and 4-toluenesufonyl groups respectively.


A trisaccharide consisting of beta-D-galactopyranose, alpha-D-glucopyranose and D-glucopyranose residues joined in sequence by (1->4) and (1->6) glycosidic bonds.


An epoxide substituted at position 2 by a hydroxymethyl group and at position 3 by a hepta-1,3,5-triyn-1-yl group (the 2S,3S)-diastereomer. It is isolated from  Trametes pubescens and exhibits antifungal properties.


A C20 phytoceramide in which the ceramide N-acyl group is specified as 2-hydroxytricontanoyl.


enteroglial cell

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Glial cell that provides support to the enteric nervous system. It is involved in enteric neurotransmission, in maintaining the integrity of the mucosal barrier of the gut and serves as a link between the nervous and immune systems of the gut. In enteric nerve strands, glial processes ensheath multiaxonal bundles which distinguishes enteric glia from all other peripheral glia. Ultrastructurally, the most conspicuous trait of an enteroglial cell is the presence of 10 nm filaments, which criss-cross the cell body, form axial bundles in the processes and appear to firmly anchor the cells to the ganglionic surfaces. Similar to astrocytes, their main constituent is glial fibrillary acidic protein (GFAP).


brain macroglial cell

description: Any macroglial cell that is part of a brain.


spinal cord oligodendrocyte

description: Any oligodendrocyte that is part of a spinal cord.


cardiac glial cell

description: Any glial cell that is part of some heart.


posterior lateral line nerve glial cell

description: Any glial cell that is part of some posterior lateral line nerve.


astrocyte of the cerebellum

description: An astrocyte of the cerebellum.


oligodendrocyte

description: A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system.


tanycyte

description: Specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. Resemble spongioblasts seen in developing brain. Found in the adult brain in the third ventricle, cerebral aqueduct, spinal canal and floor of the fourth ventricle.


forebrain radial glial cell

description: Any radial glial cell that is part of some forebrain.


lateral ventricle glial cell

description: Glial cell of lateral ventricle.


anterior lateral line nerve glial cell

description: Any glial cell that is part of some anterior lateral line nerve.


cerebral cortex glial cell

description: Glial cell of cerebral cortex.


myelinating glial cell

description: A glial cell that myelinates axonal processes.


non-myelinating Schwann cell

description: A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells.


mature astrocyte

description: A mature astrocyte that is capable of producing cytokines.


Bergmann glial cell

description: Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses.


Schwann cell

description: A glial cell that myelinates or ensheathes axons in the peripheral nervous system.


immature astrocyte

description: An immature astrocyte.


lateral line nerve glial cell

description: Any glial cell that is part of some lateral line nerve.


terminal Schwann cell

description: A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse.


macroglial cell

description: A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together.


astrocyte of the spinal cord

description: An astrocyte of the spinal cord.


myelinating Schwann cell

description: A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons.


spinal cord radial glial cell

description: Any radial glial cell that is part of some spinal cord.


astrocyte

description: A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury.


immature Schwann cell

description: A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons.


radial glial cell

description: A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration.


ependymoglial cell

description: A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space.


hippocampal glial cell

description: A glial cell that is part of the hippocampus.


Conjugate base of ascr#5-CoA


name: cerebellar granule cell to Purkinje cell synapse

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum.


An organic cation obtained by protonation of the imidazole group of (S)-isoconazole.


maltooligosaccharide

A glucooligosaccharide derived from glucose monomers linked via alpha-D-1,4 bonds as in maltose.  The term is commonly applied to the series of linear oligosaccharides composed of two, three, four, five and six such units of glucose.


maltopentaose pentasaccharide

A glucopentose comprised of five D-glucose residues connected by alpha(1->4) linkages.


maltohexaose

A maltohexaose hexasaccharide in which the glucose residue at the reducing end is in the aldehydo open-chain form.


maltotriose

A maltotriose trisaccharide in which the glucose residue at the reducing end is in the aldehydo open-chain form.


A maltohexaose hexasaccharide consisting of five alpha-D-glucopyranose residues and a D-glucopyranose residue joined in sequence by (1->4) glycosidic bonds.


maltopentaose

A maltopentaose pentasaccharide in which the glucose residue at the reducing end is in the aldehydo open-chain form.


maltotriose trisaccharide

A trisaccharide comprised of three D-glucose residues connected by alpha(1->4) linkages.


maltohexaose hexasaccharide

A glucohexaose comprised of six D-glucose residues connected by alpha(1->4) linkages.


alpha-maltoheptaose

A maltoheptaose heptasaccharide in which the glucose residue at the reducing end is in the pyranose ring form and has alpha configuration at the anomeric carbon atom.


A maltoheptaose heptasaccharide consisting of six alpha-D-glucose residues and a D-glucose residue joined in sequence by (1->4) glycosidic bonds.


maltoheptaose heptasaccharide

A heptasaccharide comprised of seven D-glucose residues connected by alpha(1->4) linkages.


alpha-maltohexaose

A maltohexaose hexasaccharide in which the glucose residue at the reducing end is in the pyranose ring form and has alpha configuration at the anomeric carbon atom.


maltoheptaose

A maltoheptaose heptasaccharide in which the glucose residue at the reducing end is in the aldehydo open-chain form.


alpha-maltopentaose

A maltopentaose pentasaccharide in which the glucose residue at the reducing end is in the pyranose ring form and has alpha configuration at the anomeric carbon atom.


O-(ADP-D-ribosyl)-L-serine(2-) residue

An organic anionic group obtained by deprotonation of the diphosphate OH groups of O-(ADP-D-ribosyl)-L-serine residue.


(+-)-gamma-cadinene

A member of the cadinene family of sesquiterpenes in which the isopropyl group is cis to the hydrogen at the adjacent bridgehead carbon


primary amino compound

A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group.


A member of the class of tryptamines that is the methyl ether derivative of serotonin.


A beta-D-GlcpN-(1->6)-D-GlcpN in which the carbon bearing the anomeric hydroxy group has alpha configuration.


(S)-tafenoquine

A N(4)-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine that has S configuration.


An amino disaccharide that is 2-amino-2-deoxy-beta-D-glucopyranose and 2-amino-2-deoxy-D-glucopyranose joined in sequence by a (1->3) glycosidic bond.


A derivative of propylamine having a methylmercapto group at the 3-position.


(2-aminoethyl)phosphonic acid

A phosphonic acid in which the hydrogen attached to the phosphorus of phosphonic acid is substituted by a 2-aminoethyl group.


An aminoalcohol that is benzene substituted by a 3-amino-3-(hydroxymethyl)-4-methoxybutyl group at position 1 and an octyl group at position 4.


A primary amino compound consisting of ethylamine having a 4-methoxyphenyl substituent at the 2-position.


A glycosylglucose derivative consisting of beta-D-galactopyranose and 2-amino-2-deoxy-D-glucopyranose residues joined in sequence by a (1->3) glycosidic bond.


(R)-(1-aminoethyl)phosphonic acid

An optically active phosphonic acid having a 1-aminoethyl group attached to the phosphorus.


AMINOTHIAZOLE

A  primary amino compound that is 1,3-thiazole substituted by an amino group at position 2.


monodansylcadaverine

A sulfonamide obtained by formal condensation of the sulfo group of 5-(dimethylamino)naphthalene-1-sulfonic acid with one of the amino groups of cadaverine.


(S)-(1-aminoethyl)phosphonic acid

A primary amino compound that is phosphonic acid having a 1-aminoethyl group attached to the phosphorus.


(R)-tafenoquine

A N(4)-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine that has R configuration.


N-acetylcadaverine

An N-substituted cadaverine that is cadaverine in which one of the amino groups has been converted to the corresponding acetamide.


An amino disaccharide consisting of 2-amino-2-deoxy-alpha-D-glucopyranose and 2-amino-2-deoxy-D-glucopyranose residues joined in sequence by a (1->6) glycosidic bond.


An  aralkylamino compound that is benzylamine substituted by a methoxy group at the para position.


ROMe

A 2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol that has R-configuration. It is a sphingosine kinase-2 inhibitor.


2-aminoacetyl fluoride

An acyl flouride that is acetyl fluoride substituted by an amino group at position 2. It is a carcinogenic agent which induces hepatocellular carcinoma in rodents.


dezocine

(7S,8S)-7-Amino-8-methyl-5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogen at position 8 and one of the hydrogens at position 6 are substituted by each end of a tetramethylene bridge. A synthetic opioid analgesic, it has mixed opiod agonist and antagonist properties. Although it is used for pain management, it can produce opioid withdrawal syndrome in patients already dependent on other opioids, and its clinical application is limited by side effects such as dizziness.


A primary amino compound that is octylamine in which one of the methyl hydrogens at position 8 has been replaced by a methylthio group.


A nitroso compound that is triazane in which the nitrogen at position 1 is substituted by an isopropyl group and a 3-aminopropyl group, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group. It is a nitric oxide donor.


alpha-allenylagmatine

A member of the class of guanidines that is agmatine in which one of the methylene hydrogens adjacent to the primary amino group has been replaced by an allenyl group.


tafenoquine

A racemate comprising equimolar amounts of (R)- and (S)-tafenoquine.


tyramine sulfate

An aryl sulfate that is tyramine in which the phenolic hydrogen at position 4 has been replaced by a sulfo group.


m-tyramine

A primary amino compound that is 2-phenylethanamine substituted by a hydroxy group at position 3.


A diether that is (ethoxymethoxy)ethane substituted by a 2-aminoethyl group at position 1.


A primary amino compound that is p-phenylenediamine in which one of the hydrogens attached to the benzene ring is replaced by a nitro group. It is a cosmetic hair dye intermediate that is used in permanent hair colouring products (diluted 1:1 with an oxidising agent prior to application).


(Z)-2-methyl-3-aminoperacrylic acid

The peracid of aminoacrylic acid where the acidic -OH group has been replaced by an -OOH group.


A primary amino compound that is heptylamine in which one of the methyl hydrogens at position 7 has been replaced by a methylsulfinyl group.


nepicastat

A member of the class of 1,3-dihydroimidazole-2-thiones that is 1,3-dihydro-2H-imidazole-2-thione in which one of the nitrogens is substituted by a 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl group while the carbon adjacent to it is substituted by an aminomethyl group (the S enantiomer). It is a potent and selective inhibitor of both bovine and human dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.


An aldoxime isolated from Streptoalloteichus sp.1454-19. It is a siderophore which exhibits immunosuppressive activity on a mixed lymphocyte culture reaction (MLCR).


The primary amino compound that is 1,2-phenylenediamine (o-phenylenediamine) substituted at the 4- (para-) position by a nitro group.


A primary amino compound that is fluorescein carrying an amino substituent at C-5. Building block/intermediate for the synthesis of the fluorescent dye flourescein; also used to produce N-(fluorescein-5-yl)maleamic acid.


N,N-didesmethylvenlafaxine

A  monomethoxybenzene that is the N,N-didesmethyl derivative of venlafaxine.


N-acetylputrescine

An N-monoacetylalkane-alpha,omega-diamine that is the N-monoacetyl derivative of putrescine.


A diamine that is toluene in which both of the hydrogens ortho- to the methyl group are replaced by amino groups.


dopamine 4-O-sulfate

An aryl sulfate that is dopamine in which the phenolic hydrogen at position 4 has been replaced by a sulfo group.


An aminoglycoside that is 4alpha,6alpha-diaminocyclohexane-1beta,2alpha,3beta-triol in which the pro-R hydroxy group has been converted into its 2-amino-2,3-dideoxy-alpha-D-erythro-hexopyranosid-4-ulose derivative.


alendronate

A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.


(3-aminopropyl)phosphonic acid

A phosphonic acid in which the hydrogen attached to the phosphorus of phosphonic acid is substituted by a 3-aminopropyl group. It is a partial agonist of GABAB receptors.


benserazide

A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.


A member of the class of pteridines that is pteridine in which the hydrogens at positions 2 and 4 are replaced by amino groups, whilst those at positions 6 and 7 are replaced by isopropyl groups.


An amino alcohol that is alanine in which the carboxy group has been reduced to the corresponding alcohol.


A member of the class of guanidines in which the imino hydrogen of guanidine itself has been replaced by a 7-aminoheptyl group. It is an inhibitor of deoxyhypusine synthase activity (GO:0034038).


tromethamine

A primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 7--9; pKa = 8.3 at 20 degreeC; pKa = 7.82 at 37 degreeC.


Jeffamine M-600

A polyether that is a nine-membered polypropylene glycol terminated by an amino group at one end and a methoxyethyl termination at the other. A common crystallisation reagent.


A member of the class of tryptamines that is tryptamine substituted by a methyl group at position 5.


An amino alcohol that is dodeca-2,6,8,10-tetraen-1-amine in which all four double bonds have trans configuration and in which the pro-S hydrogen at position 5 has been replaced by a hydroxy group.


A thiopyranopyrimidine that is 1,5,7,8-tetrahydro-4H-thiino[4,3-d]pyrimidin-4-one which is substituted at position 2 by a p-(aminomethyl)phenyl group.


A member of the class of phenylureas obtained by formal condensation of the carboxy group of (3-{5-[4-(aminomethyl)phenyl]pyrrolo[2,3-b]pyridin-3-yl}phenyl)carbamic acid with the amino group of 2-phenoxyaniline. An inhibitor of tyrosine kinase.


stealthin C

An organic heterotetracyclic compound that is 10H-benzo[b]fluorene substituted by a methyl group at position 1, hydroxy groups at positions 4, 5 and 9, oxo group at position 10, and an amino group at position 11.


mexiletine

An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.


L-ALANINOL

A 2-aminopropan-1-ol that has S-configuration.


An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.


An amino disaccharide consisting of 2-amino-2-deoxy-beta-D-glucopyranose and 2-amino-2-deoxy-D-glucopyranose residues joined in sequence by a (1->6) glycosidic bond.


DESGLYMIDODRINE

An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-amino-1-hydroxyethyl group. The immediate and active metabolite of midrodine, it is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. Midrodine is used (generally as its hydrochloride salt) as a prodrug for deglymidodrine, which acts as a peripheral vasoconstrictor in the treatment of certain hypotensive states.


A 2-aminopropan-1-ol that has R-configuration.


A primary amino compound that is octylamine in which one of the methyl hydrogens at position 8 has been replaced by a methylsulfinyl group.


N-demethylindolmycin

A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted at the 2 and 5-pro-S positions by amino and [(1R)-1-(1H-indol-3-yl)ethyl] groups, respectively.


A C-nitro compound isolated from Streptoalloteichus sp.1454-19. It is a siderophore which exhibits immunosuppressive activity on a mixed lymphocyte culture reaction (MLCR).


diamino-poly(ethylene glycol)

A poly(ethylene glycol) terminated with -NH2 groups.


A 1,3-thiazole that is 4,5-dihydro-1,3-thiazole substituted by an amino group at position 2.


itramin tosilate

A nitrate ester resulting from the formal condensation of the hydroxy group of ethanolamine with the hydroxy group of nitric acid. It causes vasodilation by generating nitric oxide and is used for the treatment of angina pectoris and ischemic heart disease.


N-monoacetylalkane-alpha,omega-diamine

An acetamide obtained by acetylation of one of the amino groups of any alkane-alpha,omega-diamine. AcNHCH2(CH2)nCH2NH2, where n = 0, 1, 2, etc.


A tryptamine derivative that consists of serotonin bearing an additional O-nonyl substituent. 5-HT1B selective agonist, several times more potent than sumatriptan and inactive as a 5-HT1A agonist (Ki at 5-HT1B = 1 nM, selectivity over 5-HT1A > 300-fold).


An amino trisaccharide consisting of alpha-L-fucopyranose, beta-D-galactopyranose and 2-amino-2-deoxypyranose joined in sequence by (1->2) and (1->3) glycosidic bonds.


alpha-D-galactosamine

A 2-amino-2-deoxy-D-galactopyranose that has alpha- configuration at the anomeric centre.


The pyranose form of D-galactosamine.


AMINO(PHENYL)METHYLPHOSPHONIC ACID

A member of the class of  phosphonic acids that is phosphonic acid having a amino(phenyl)methyl group attached to the phosphorus.


6-bromo-2-naphthyl beta-D-mannoside

A beta-D-mannoside having a 6-bromo-2-naphthyl substituent at the anomeric position.


pentolonium

A dication whose structure comprises a pentane backbone linking two 1-methylpyrrolidinium groups; a nicotinic antagonist used as a ganglionic blocking agent in hypertension.


Elemental mercury of oxidation state zero.


An L-alpha-amino acid residue derived from N-acetyl-alpha-D-glucosaminyl-L-threonine.


A resorcinol compound having an 8-cis,11-cis-pentadeca-8,11,14-trien-1-yl substituent at the 5-position.


acetoxysulfonic acid

An acyl sulfate where the acyl group is specified as acetyl.


picrocrocin

A beta-D-glucoside of beta-cyclocitral; the precursor of safranal. It is the compound most responsible for the bitter taste of saffron.


A glycophytoceramide having an alpha-D-galactopyranosyl residue at the O-1 position and an undecanoyl group attached to the nitrogen.


A peptide cation obtained by deprotonation of the carboxy terminus and protonation of the amino groups of Lys-Ala; major species at pH 7.3.


doxycycline

Tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis.


Val-Tyr-Val

A tripeptide formed from L-valine, L-tyrosine and L-valine residues joined in sequence.


CoA ester of ascr#13


aldehydo-L-lyxose

An L-lyxose in open-chain aldehyde form.


A secondary fatty alcohol that is octadecane substituted by a hydroxy group at position 2.


heazlewoodite

A sulfide mineral with formula Ni3S2 which is named after Heazlewood, Tasmania, where it was first described.


platinum nanoparticle

A nanoparticle consisting of platinum atoms.


A platinum coordination entity that is the cationic portion of triplatin tetranitrate.


A platinum coordination entity consisting of two units of ethane-1,2-diamine co-ordinated via its amino groups to di-mu-iododiplatinum.


(R,R,S)-lobaplatin

The (R,R,S)-isomer of lobaplatin.


platinum dichloride

A platinum coordination entity consisting of platinum(II) bound to two chlorine atoms.


NiFe4S4 cluster

A nickel-iron-sulfur cluster in which the nickel and iron atoms are linked by bridging sulfur atoms with the ratio Ni:Fe:S = 1:4:4.


nickel-sirohydrochlorin

A metalloporphyrin that is sirohydrochlorin in which the four nitrogen atoms are bound to a central nickel atom.


A platinum coordination entity consisting of cyclohexane-1,2-diamine co-ordinated via its amino groups to tetrachloroplatinum.


NiFe3S4 cluster

A nickel-iron-sulfur cluster in which the nickel and iron atoms are linked by bridging sulfur atoms in a cubane-type structure with the ratio Ni:Fe:S = 1:3:4.


palladium(II) chloride

A palladium coordination entity consisting of palladium(II) bound to two chlorine atoms.


A platinum coordination entity that consists of a central platinum atom bound to chloro (x2), hydroxy (x2), amino, and cyclohexylamino groups.


nickel-iron-sulfur cluster

An  iron-sulfur cluster comprising both nickel and iron atoms and bridging sulfur ligands.


nickel-sirohydrochlorin a,c-diamide

A metalloporphyrin that is sirohydrochlorin a,c-diamide in which the four nitrogen atoms are bound to a central nickel atom.


lobaplatin

A 1:1 diastereomeric mixture comprising of R,R,S and S,S,S configuration of platinum(II) complexes with 1,2-bis(aminomethyl)cyclobutane as the carrier ligand and lactate as the leaving group. It is a third-generation platinum anticancer drug approved in China for the treatment of chronic myelogenous leukaemia, inoperable metastatic breast cancer and small cell lung cancer.


A tetrachloro(cyclohexane-1,2-diamine-kappa(2)N,N')platinum that is the pharmacologically inactive (1S,2S)-enantiomer of ormaplatin.


nickel dichloride

A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.


dexormaplatin

A tetrachloro(cyclohexane-1,2-diamine-kappa(2)N,N')platinum that is the pharmacologically active (1R,2R)-enantiomer of ormaplatin.


A nickel coordination entity that is (S)-citronellalthiosemicarbazonate complexed with nickel in a 2:1 ratio. It induces apoptosis and exhibits anticancer properties.


satraplatin

A platinum coordination entity that consists of a central platunum atom bound to chloro (x2), acetate (x2), amino, and cyclohexylamino groups. Used for treatment of advanced prostate cancer.


nickel subsulfide

A nickel coordination entity with formula Ni3S2. Used in the manufacture of lithium batteries.


carboplatin

A platinum coordination entity with cis square-planar geometry in which  platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand.


NiFe4S5 cluster

A nickel-iron-sulfur cluster in which the nickel and iron atoms are linked by bridging sulfur atoms with the ratio Ni:Fe:S = 1:4:5.


oxaliplatin

A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.


A metalloporphyrin having nickel as the central metal atom; an intermediate in the biosynthesis of coenzyme F430 in methanogenic bacteria.


name: 6-fluoro-3-pyridinecarboxylic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester


St. John's wort extract

A mixture resulting from extraction from the leaves of St. John's wort (Hypericum perforatum).


ciguatoxin

Ciguatoxins are cyclic polyether toxins, derived from marine dinoflagellates, which are responsible for the symptoms of ciguatera poisoning. Ingestion of tropical and subtropical fin fish contaminated by ciguatoxins results in an illness characterised by neurological, cardiovascular and gastrointestinal disorders.


ciguatoxin CTX4B

A ciguatoxin comprising a sequence of twelve trans-fused six-, seven-, eight- and nine-membered oxacycles and a spiro-fused tetrahydrofuran substituted by a (1E)-buta-1,3-dien-1-yl side chain. It is isolated from Gambierdiscus toxicus.


ciguatoxin CTX1B

A ciguatoxin comprising a sequence of twelve trans-fused six-, seven-, eight- and nine-membered rings and a spiro-fused five-membered ring. A commonly encountered fish toxin.


51-hydroxy ciguatoxin CTX3C

A ciguatoxin comprising a sequence of twelve trans-fused six-, seven-, eight- and nine-membered oxacycles and a spiro-fused hydroxytetrahydrofuran ring.


ciguatoxin CTX3C

A ciguatoxin comprising a sequence of twelve trans-fused six-, seven-, eight- and nine-membered oxacycles and a spiro-fused tetrahydrofuran.


BREVETOXIN A

A ciguatoxin comprising a linear sequence of ten trans-fused five-, six-, eight- and nine-membered rings.


metabolite of prednisolone


A heptasaccharide consisting of two alpha-maltotriose units linked (1->6), with a further alpha-D-glucose unit linked to O-6 of the glucose residue at the non-reducing end.


MEDRONIC ACID

A 1,1-bis(phosphonic acid) consisting of methane substituted by two phosphonic acid groups.


flerovium atom

A carbon group element atom with a symbol Fl and atomic number 114.


17beta-hydroxy steroid

A 17-hydroxy steroid in which the hydroxy group at position 17 has a beta-configuration.


ethylestrenol

A 17beta-hydroxy steroid that is estrane containing a double bond between positions 4 and 5 and substituted by an ethyl group and a hydroxy group at the 17alpha and 17beta positions, respectively. It is an anabolic steroid that has little androgenic effect and only slight progestational activity. It has been used to promote growth in boys with delayed bone growth.


A steroid glucosiduronic acid that is 2-methoxy-17beta-estradiol having a single beta-D-glucuronic acid residue attached at position 3.


2-hydroxyestradiol 3-methyl ether

A 17beta-hydroxy steroid that is 17beta-estradiol in which the hydrogen at position 2 has been replaced by a hydroxy group and the phenolic hydrogen at position 3 has bee replaced by a methyl group.


mestranol

A terminal acetylenic compound that is (17alpha)-17-ethynylestra-1(10),2,4-triene substituted by a methoxy group at position 3 and a hydroxy group at position 17.


A steroid glucosiduronic acid that is 4-hydroxy-17beta-estradiol having a single beta-D-glucuronic acid residue attached at position 3.


tibolone

Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormone receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.


A steroid glucosiduronic acid that is 5alpha-androstane-3beta,17beta-diol having a single beta-D-glucuronic acid residue attached at position 3. It is a biochemical marker of peripheral tissue androgen metabolism.


A steroid glucosiduronic acid that is 2-hydroxy-17beta-estradiol having a single beta-D-glucuronic acid residue attached at position 3.


A 2-hydroxy steroid that consists of 17beta-estradiol having an additional hydroxy group at position 2.


17beta-estradiol 3-glucosiduronic acid

A steroid glucosiduronic acid that consists of 17beta-estradiol having a beta-glucuronyl residue attached at position 3 via a glycosidic linkage.


L-cysteinyl group

The cysteinyl group with L stereochemistry at C-2.


purine type


S-hexylglutathione

An S-substituted glutathione that is glutathione in which the hydrogen of the thiol has been replaced by a hexyl group (PDB entry: 1PN9).


citalopram hydrobromide

A racemate comprising equimolar amounts of (R)-citalopram hydrobromide and escitalopram hydrobromide. It is used for the treatment of depression. Only the (S)-enantiomer, (escitalopram hydrobromide) is active.


A diol that is propane 1,3-diol bearing additional amino and 4-nitrophenyl substituents at positions 2 and 1 respectively.


name: 7-(2,5-dimethoxyphenyl)-5-(trifluoromethyl)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester


An N-acyl-1-O-beta-D-glucosyl-4-hydroxy-15-methylhexadecasphinganine in which the acyl group has 20 carbons and 0 double bonds.


A class of glucoglycerolipids that consists of any 1,2-diacyl-sn-glycerol having an alpha-D-glucosyl residue attached at position 3.


terbutaline

A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.


phytochelatin 2

A phytochelatin that is a pentapeptide consisting of 2 units of gamma-Glu-Cys, with a glycyl unit at the C-terminus.


beta-D-fucose

A D-fucopyranose with a beta-configuration at the anomeric position.


A glycohexaosylceramide having a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc component attached to the primary hydroxy function of a ceramide with undefined sphingoid base and fatty acyl chain.


name: benzoic acid (17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl) ester


A linear amino tetrasaccharide comprising an alpha-N-glycoloylneuraminyl residue, an alpha-N-acetylneuraminyl residue, a beta-D-galactose residue and (at the reducing end) an N-acetyl-D-glucosamine residue, linked sequentially (2->8), (2->3) and (1->4).


A glycoside consisting of alpha-Neup5Ac-(2->6)-alpha-D-GalpNAc linked glycosidically to a propargyl (prop-2-yn-1-yl) group.


catechols

Any compound containing an o-diphenol component.


A member of the class of  catechols that is benzene-1,2-diol substituted by a (all-trans)-hexaprenyl group at position 3.


A para-terphenyl that is the 3-hydroxy derivative of  terphenyllin. It has been isolated from Aspergillus taichungensis.


azodopa

An azobenzene whose structure comprises of benzene-1,2-diol and N,N-dimethyl-2-phenylethanamine linked by a N=N double bond. It is a photoswitchable dopamine agonist.


isoprenaline

A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.


GRIFFITHANE C

A member of the class of catechols that is benzene-1,2-diol substituted by a methoxy group at position 5 and a 3-(3,4-dimethoxyphenyl)propyl group at position 4. It has been isolated from the stems of Combretum griffithii.


A lignan that is 1,2,3,4-tetrahydronaphthalene substituted by methyl groups at positions 2 and 3, a hydroxy group at position 7, a methoxy group at position 6  and a 3,4-dihydroxyphenyl group at position 1. It has been isolated from the bark of Machilus robusta.


PRENYLTERPHENYLLIN A

A para-terphenyl that is 1,1':4',1''-terphenyl substituted by methoxy groups at positions 3' and 6', a prenyl group at position 3'' and hydroxy groups at positions 2', 3, 4 and 4''. Isolated from the fungus, Aspergillus taichungensis, it exhibits cytotoxic activity.


droxidopa

A serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension


A diarylheptanoid that is heptan-3-ol substituted by a 3,4-dihydroxyphenyl group at position 1 and a 4-hydroxyphenyl group at position 7 (the 3R-stereoisomer). It has been isolated from the rhizomes of Curcuma kwangsiensis.


2,2',3-trihydroxydiphenyl ether

Diphenyl ether in which the hydrogens at the 2, 3, and 2' positions are substituted by hydroxy groups.


Catechol substituted at positions 5 and 6 (3 and 4) with methyl groups and at position 6 (3) with a pentadecyl group.


A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1, an allyl substituent at position 3 and two hydroxy substituents at positions 7 and 8. Selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.


name: 3,4-Dihydroxyphenyllactic acid methyl ester


A member of the class of catechols that is benzene-1,2-diol substituted by a nitro group at position 4.It is the by-product of the hydroxylation of p-nitrophenol.


A member of the class of catechols that is catechol which is substituted by a propyl group at position 3. It is a chemical component in tobacco.


Catechol substituted at positions 3, 4 and 5 (4, 5 and 6) with methyl groups and at position 6 (3) with a pentadecyl group.


A para-terphenyl that is the 4''-dehydro derivative of 3-hydroxyterphenyllin. It has been isolated from Aspergillus taichungensis.


A member of the class of indoles that is indoline with hydroxy substituents at positions 3,5 and 6.


(E)-caffeyl alcohol

A caffeyl alcohol in which the double bond has E geochemistry.


(E)-5-hydroxyconiferyl alcohol

A 5-hydroxyconiferyl alcohol in which the double bond has E geochemistry.


5-hydroxyconiferyl alcohol

A phenylpropanoid that is cinnamyl alcohol in which the hydrogens at positions 3 and 4 on the benzene ring are replaced by hydroxy groups while that at position 5 is replaced by a methoxy group.


tricholignan A

A methylcatechol that is benzene substituted by hydroxy, hydroxy, (3E)-penta-1,3-dien-1-yl, methyl and methoxy groups at positions 1, 2, 3, 4 and 5, respectively. It is an iron(III)-reducing natural product isolated from the ascomycota Trichoderma harzianum.


A member of the class of catechols carrying two bromo substituents at positions 3 and 5.


A catechol bearing an additional fluoro substituent at position 3.


A nitrotoluene that is 2-nitrotoluene carrying two hydroxy substituents at positions 5 and 6.


CORDYOL C

A catechol that is 5-methylbenzene-1,2-diol bearing a 3-hydroxy-5-methylphenoxy substituent at position 3.


BRAZILIN

A organic heterotetracyclic compound that is a red pigment obtained from the wood of Caesalpinia echinata (Brazil-wood) or Caesalpinia sappan (sappan-wood).


A member of the class of catechols that is catechol in which one of the hydrogens that is ortho to a hydroxy group has been replaced by an isopropyl group.


CATECHOL

A  benzenediol comprising of a benzene core carrying two hydroxy substituents ortho to each other.


A  lignan that is 1,2,3,4-tetrahydronaphthalene substituted by methyl groups at positions 2 and 3, a methoxy group at position 6, a hydroxy group at position 7 and a 3,4-dihydroxy-5-methoxyphenyl group at position 1. It has been isolated from the bark of Machilus robusta.


A  diarylheptanoid that is (6E)-6-hepten-3-ol substituted by a 3,4-dihydroxyphenyl group at position 1 and a 4-hydroxyphenyl group at position 7 respectively. It has been isolated from the rhizomes of Curcuma comosa.


A  diarylheptanoid that is heptan-3-ol substituted by a 3,4-dihydroxyphenyl group at position 1 and a 4-hydroxyphenyl group at position 7 (the 3S-stereoisomer). It has been isolated from the rhizomes of Curcuma kwangsiensis.


A methylcatechol that is 3-nitrocatechol carrying a methyl substituent at position 5.


A methylcatechol that is 4-methylcatechol in which the hydrogen at position 3 has been replaced by a nitro group.


Catechol substituted at position 3 with a pentadecyl group.


COLTEROL

A member of the class of ethanolamines that is catechol in which the hydrogen at position 4 is replaced by a 2-(tert-butylamino)-1-hydroxyethyl group.


methylcatechol

Any member of the class of catechols carrying one or more methyl substituents.


A methylcatechol having a single methyl substituent at the 4-position. It has been isolated from Picea abies.


caffeyl alcohol

A phenylpropanoid that is cinnamyl alcohol in which the hydrogens at positions 3 and 4 on the benzene ring are replaced by hydroxy groups.


A member of the class of  hydroxybiphenyls that is 1,1'-biphenyl substituted by hydroxy groups at positions 2 and 3.


A  lignan that is 2,3-dimethylbutane substituted by a 4-hydroxy-3-methoxyphenyl group a position 4 and a 3,4-dihydroxy-5-methoxyphenyl group at position 1. It has been isolated from the bark of Machilus robusta.


violaceol I

An aromatic ether in which the ether functionality links two 2,3-dihydroxy-5-methylphenyl groups.  Fungal metabolite isolated inter alia from Aspergillus spp.


PRENYLTERPHENYLLIN C

A para-terphenyl that is 1,1':4',1''-terphenyl substituted by methoxy groups at positions 3' and 6', a prenyl group at position 5 and hydroxy groups at positions 2', 3, 4 and 4''. Isolated from the fungus, Aspergillus taichungensis, it exhibits cytotoxic activity.


litreol

Catechol carrying a pentadecenyl substituent at position 3.


hydroxytyrosol

A member of the class of catechols that is benzene-1,2-diol substituted by a 2-hydroxyethyl group at position 4. Isolated from Olea europaea, it exhibits antioxidant and antineoplastic activities.


A methylcatechol carrying a methyl substituent at position 3. It is a xenobiotic metabolite produced by some bacteria capable of degrading nitroaromatic compounds present in pesticide-contaminated soil samples.


PICEATANNOL

A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.


The cis-stereoisomer of cyclohexa-3,5-diene-1,2-diol.


A  diarylheptanoid that is (6E)-6-hepten-3-ol substituted by a 3,4-dihydroxyphenyl group at position 1 and a phenyl group at position 7 (the 3S- stereoisomer). It has been isolated from the rhizomes of Curcuma kwangsiensis.


A  para-terphenyl that is the 3,3''-dihydroxy derivative of  terphenyllin. It has been isolated from Aspergillus taichungensis.


scroside D

A disaccharide derivative that consists of hydroxytyrosol in which the alcoholic hydroxy group is glycosylated with a 3-O-beta-D-glucopyranosyl-D-glucopyranosyl residue. Isolated from Picrorhiza scrophulariiflora, it exhibits antioxidant activity.


(8Z,11Z)-urushiol III

Catechol substituted at position 3 with an (8Z,11Z)-pentadeca-8,11-dien-1-yl group. Stereoisomer of urushiol III (CHEBI:9909) which has (8E,11E) configuration.


A tyrosine derivative that is L-tyrosine in which the hydrogens at positions 3 and 5 on the phenyl ring are replaced by a methyl and hydroxy groups respectively.


A secondary carboxamide resulting from the formal condensation of a molecule of dihydrocaffeic acid with each of the primary amino groups of spermidine. Found in potato tubers.


violaceol II

An aromatic ether in which the ether functionality links a 2,3-dihydroxy-5-methylphenyl group with a 2,6-dihydroxy-4-methylphenyl group. Fungal metabolite isolated inter alia from Aspergillus spp.


The simplest member of the class of  3-ethylcatechols that is catechol bearing an ethyl substituent at position 3.


A  diarylheptanoid that is (6E)-6-hepten-3-ol substituted by a 3,4-dihydroxyphenyl group at position 1 and a 4-hydroxyphenyl group at position 7 (the 3S-stereoisomer). It has been isolated from the rhizomes of Curcuma kwangsiensis.


trans-azodopa

The trans isomer of azodopa.


A member of the class of catechols that is catechol in which a hydrogen that is ortho to one of the hydroxy groups has been replaced by a methoxy group. It displays agonistic activity against G protein-coupled receptor 35 (GPR35).


An organic anionic group obtained by deprotonation of the free phosphate OH group of N(6)-methyladenosine 5'-monophosphate residue.


A branched amino octasaccharide consisting of a linear pentasaccharide comprising N-acetyl-beta-D-galactosamine, beta-D-galactose, two L-glycero-alpha-D-manno-heptose (L-alpha-D-Hep) residues and a 3-deoxy-alpha-D-manno-oct-2-ulose (alpha-Kdo) residue linked in sequence (1->4), (1->3),(1->3) and (1->5), to the L-alpha-D-Hep residue proximal to the reducing end is also linked (1->4) a beta-D-glucose residue, while the galactose residue also carries an N-acetyl-alpha-neuraminic acid residue via a (2->3) linkage and the alpha-Kdo residue also carries a second alpha-Kdo residue linked (2->-4). One of a number of chemoenzymatically synthesised oligosaccharides composed of the inner core oligosaccharide of Campylobacter jejuni extended by various ganglioside mimics.


An amino disaccharide consisting of N-acetyl-beta-D-glucosamine, substituted on O-3 with a 1-carboxyethyl group and linked (1->4) to a second N-acetyl-beta-D-glucosamine residue.


A tetrahydrofolyl-poly(glutamic acid) polymer in which the glutamic acid residues all have L-configuration.


A branched amino octasaccharide derivative that is beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc in which the mannosyl group is substituted at position 6 by a beta-D-GlcNAc-(1->2)-alpha-D-Man group and at position 3 by a beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man group.


A branched amino octasaccharide derivative that is beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc in which the mannosyl group is substituted at position 6 by a beta-D-GlcNAc-(1->2)-alpha-D-Man group and at position 3 by a beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man group.


probucol

A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.


D-glucosyl-N-acylsphingosine

Sphingosine substituted at the 1-hydroxy group by a D-glucosyl group and at the 2-amino group by an acyl group.


A beta-D-glucosyl-N-acylsphingosine in which the acyl group is specified as octadecanoyl.


A D-glucosyl-N-acylsphingosine in which the ceramide N-acyl group is dodecanoyl.


A beta-D-glucosylceramide where the ceramide N-acyl group is specified as docosanoyl.


A beta-D-glucosylceramide where the ceramide N-acyl group is specified as hexacosanoyl.


A beta-D-glucosyl-N-acylsphingosine in which the acyl group is specified as (17Z)-hexacosenoyl.


A beta-D-glucosyl-N-acylsphingosine in which the acyl group is specified as hexadecanoyl.


A beta-D-glucosyl-N-acylsphingosine in which the acyl group is specified as tricosanoyl.


beta-D-glucosyl-N-(oleoyl)sphingosine

An N-acyl-beta-D-galactosylsphingosine where the ceramide N-acyl group is specified as oleoyl.


beta-D-glucosyl-N-eicosanoylsphingosine

A beta-D-glucosyl-N-acylsphingosine in which the acyl group is specified as eicosanoyl.


name: 2,6-dimethyl-3,4-dihydropyridine-3,4,5-tricarboxylic acid O4-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl] ester O3,O5-diethyl ester


name: 8-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinecarboxylic acid ethyl ester


N-propanoylimidazole

An N-acylimidazole compound having propanoyl as the acyl group.


An amino trisaccharide consisting of two alpha-D-mannopyranose residues and a 2-acetamido-2-deoxy-D-glucopyranose residue joined in sequence by (1->2) and (1->3) glycosidic bonds.


A secondary fatty alcohol that is docosane substituted by a hydroxy group at position 11.


A galactosiduronic acid resulting from the formal condensation of the anomeric hydroxy group of beta-D-galactopyranuronic acid with the phosphate group of ditrans,polycis-dodecaprenyl phosphate.


poly(ethyl methacrylate) polymer

An acrylic polymer, composed of poly(ethyl methacrylate) macromolecules.


A synthetic pentapeptide comprising Ac-Cha, Arg, Tic, Met and betaPhPro-NH2 residues coupled in sequence.


A secondary alcohol that is pentane substituted by a hydroxy group at position 3. It is produced by plants and is a component of emitted insect sex pheromones.


name: 4-[2-(2,4-dimethoxyanilino)-2-oxoethyl]-5-thieno[3,2-b]pyrrolecarboxylic acid ethyl ester


succinamic acid

A dicarboxylic acid monoamide of succinic acid.


An alpha-amino-acid residue anion obtained by deprotonation of the carboxy groups of C-terminal-gamma-(L-glutamyl)-L-2-glutamic acid group. Major structure at pH 7.3.


sulfur hexafluoride

A sulfur coordination entity consisting of six fluorine atoms attached to a central sulfur atom. It is the most potent greenhouse gas currently known, with a global warming potential of 23,900 times that of CO2 over a 100 year period (SF6 has an estimated lifetime in the atmosphere of between 800 and 3,000 years).


A medium-chain primary fatty alcohol that is (Z)-non-6-ene carrying a hydroxy group at position 1. It has been found in muskmelon and watermelon.


demecolcine

A secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic.


An N-acyl-1-O-beta-D-glucosyl-15-methylhexadecasphing-4-enine in which the acyl group has 26 carbons and 4 double bonds and is 2-hydroxylated.


name: 3-amino-5-methoxy-2-benzofurancarboxylic acid methyl ester


A hexosyl ceramide with C17iso branched chain sphingoid base and C25:0(OH) N-Acyl. Sum formula is C48H93NO9


An organic anionic group obtained by deprotonation of the free phosphate OH and carboxy groups of 2-thio-N(6)-L-threonylcarbamoyladenine 5'-monophosphate residue.


An anthocyanin cation that is malvidin substituted at position 3 by a 6-O-acetyl-beta-D-glucosyl residue.


S-nitroso-N-acetyl-D-penicillamine

A nitroso compound that is N-acetyl-D-penicillamine in which the sulfanyl hydrogen is replaced by a nitroso group.


nitrosothio compound

Any nitroso compound in which a carbon atom of an organyl group is attached to the sulfur atom of a nitrosothio group: R-S-N=O.


S-nitroso-coenzyme A

A nitrosothio compound that is coenzyme A in which the thiol group is replaced by a nitrososulfanediyl group.


CHRYSOGESIDE B

A glucosylceramide isolated from Penicillium chrysogenum.


BUTADIENE

A  butadiene with unsaturation at positions 1 and 3.


name: 2-[(2S,5R,6S)-6-(hydroxymethyl)-5-[(4-methoxyphenyl)sulfonylamino]-2-oxanyl]acetic acid methyl ester


hernancorizin

A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 5 and 2' and methoxy groups at positions 7, 4' and 5'. It has been isolated from  Mimosa diplotricha.


An isoquinolinol that is 5-hydroxyisoquinolin-1(2H)-one which has been substituted at positions 4 and 8 by phenyl and methoxy groups, respectively. Isolated from the fermentation of an endophytic fungus Penicillium sp. R22 in Nerium indicum. It displayed weak antibacterial activity.


glyoxysomal lumen

description: The volume enclosed by the membranes of a glyoxysome.


glycosome lumen

description: The volume enclosed by the membrane of a glycosome.


An N-acyl-15-methylhexadecasphing-4-enine in which the acyl group has 26 carbons and 0 double bonds.


name: N-(very-long-chain fatty acyl)-sphingoid base

description: A ceramide where the acyl chain chain length is greater than C22 and the sphingoid base is undefined


N-hexacosanoylsphingosine

A N-acylsphingosine in which the ceramide N-acyl group is specified as hexacosanoyl.


N-(tetracosanoyl)eicosasphinganine

A ceramide that is the N-tetracosanoyl derivative of eicosasphinganine.


A dihydroceramide obtained by formal condensation of the carboxy group of tetracosanoic acid with the amino group of 14-methylhexadecasphinganine. It is a metabolite of the nematode Caenorhabditis elegans.


N-hexacosanoylsphinganine

A dihydroceramide compound having a hexacosanoyl group attached to the nitrogen atom.


A ceramide obtained by formal condensation of the carboxy group of hexacosanoic acid with the amino group of 14-methylhexadecasphinganine. It is a metabolite of the nematode Caenorhabditis elegans.


N-tetracosenoyl-sphingoid base

A ceramide having a tetracosenoyl fatty chain where the double bond position is not defined, and also the sphingoid base is undefined.


A ceramide obtained by formal condensation of the carboxy group of hexacosanoic acid with the amino group of 14-methylhexadecasphingosine. It is a metabolite of the nematode Caenorhabditis elegans.


N-hexacosanoylphytosphingosine

A phytoceramide compound having a hexacosanoyl group attached to the nitrogen atom.


A ceramide that is the N-hexacosanoyl derivative of C20 phytosphingosine.


An N-acyl-15-methylhexadecasphing-4-enine in which the acyl group has 24 carbons and 0 double bonds.


N-tetracosanoylsphingosine

A N-acylsphingosine in which the ceramide N-acyl group is specified as tetracosanoyl.


A ceramide that is the N-tetracosanoyl derivative of C17-sphingosine.


N-hexacosanoylicosasphinganine

A C20 dihydroceramide in which the ceramide N-acyl group is specified as hexacosanoyl.


N-tetracosanoyl-sphingoid base

A ceramide having a tetracosanoyl chain with an undefined sphingoid base.


A dihydroceramide in which the acyl moiety contains 24 carbons and 1 double bond.


tertiary amino compound

A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups.


karakoline

An organonitrogen heterocyclic compound that is aconitane bearing hydroxy groups at the 1alpha, 8, and 14alpha positions and substituted at on the nitrogen and at positions 4 and 16beta by ethyl, methyl, and methoxy groups, respectively.


aporphine

An isoquinoline alkaloid that is the N-methyl derivative of  5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline.


(R)-laudanosine

A benzylisoquinoline alkaloid that is (R)-tetrahydropapaverine in which the amino hydrogen has been replaced by a methyl group


A quinolizidine alkaloid obtained by formal dehydrogenation at the 5,6-position of sparteine. It is a metabolite of sparteine found in human urine and plasma.


desvenlafaxine

A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine.


ORYZALIN

A sulfonamide that is benzenesulfonamide substituted at positions 3 and 5 by nitro groups and at position 4 by a dipropylamino group.


tramadol

A tertiary alcohol that is cyclohexanol substituted at positions 1 and 2 by 3-methoxyphenyl and dimethylaminomethyl groups respectively.


A sulfonamide formed by dansylation of 4-aminobenzylamine; used as a fluorescence-labelled model hapten.


bromodiphenhydramine

A  tertiary amino compound that is the 4-bromobenzhydryl ether of 2-(dimethylamino)ethanol. An antihistamine with antimicrobial properties, it is used in the control of cutaneous allergies.


benzydamine

A member of the class of indazoles carrying benzyl and 3-(dimethylamino)propyl groups at positions 1 and 3 respectively. A locally-acting nonsteroidal anti-inflammatory drug that also exhibits local anaesthetic and analgesic properties.


AFIMOXIFENE

A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.


DIETHYLLENETRIAMINE NONOATE

A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group.


nefopam

A racemate comprising equal amounts of (R)- and (S)-nefopam. The  hydrochloride is a centrally acting non-opiate analgesic commonly used for the treatment of moderate to severe pain.


sarpagine

An indole alkaloid that is sarpagan bearing hydroxy groups at positions 10 and 17.


A member of the class of azobenzenes that is azobenzene in which one of the phenyl groups is substituted at position 3 by a methyl group, while the other is substituted at position 4 by a dimethylamino group. It is a potent liver carcinogen.


diphenhydramine

An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.


N-methylproline

An L-proline derivative obtained by replacement of the amino hydrogen by a methyl group.


glyphosine

A tertiary amino compound that consists of glycine bearing two N-phosphonomethyl substituents.


DABCO

An organic heterobicylic compound that is piperazine with an ethane-1,2-diyl group forming a bridge between N1 and N4. It is typically used as a catalyst in polymerization reactions.


LISSOCLIBADIN 1

An  organosulfur heterocyclic compound isolated from the ascidian Lissoclinum badium. It has been shown to exhibit cytotoxicity against human cancer cell lines.


(+)-argemonine

The (+)-(R,R)-enantiomer of argemonine.


(S)-bromazine

The (S)-enantiomer of bromazine.


nothramicin

An anthracycline antibiotic isolated from the culture broth of Nocardia sp. MJ896-43F17. It exhibits significant antimycobacterial activity against several drug-resistant Mycobacterium smegmatis strains.


protostrychnine

A monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from Strychnos icaja and Strychnos nux-vomica.


ISOSTRYCHNINE

A monoterpenoid indole alkaloid with formula C21H22N2O2, originally isolated from the seeds of Strychnos nux-vomica.


(S,S)-tramadol

A 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have S-configuration; the (S,S)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold lower analgesic potency than the (R,R)-enantiomer.


An isoquinoline alkaloid that is 13-methyl-5,6,11,12-tetrahydro-5,11-epiminodibenzo[a,e][8]annulene substituted at positions 2, 3, 8 and 9 by methoxy groups.


atglistatin

A biphenyl that is 1,1'-biphenyl substituted by (dimethylcarbamoyl)amino and dimethylamino groups at positions 3 and 4', respectively. It is a potent inhibitor of adipose triglyceride lipase activity (IC50 = 700nM).


ivabradine

A member of the class of benzazepines that is 7,8-dimethoxy-1,3,4,5-tetrahydro-3-benzazepin-2-one in which the amide hydrogen is replaced by a [{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl} group. Used (as its hydrochloride salt) to treat patients with angina who have intolerance to beta blockers and/or heart failure.


DAURICINE

A bisbenzylisoquinoline alkaloid resulting from the formal oxidative dimerisation of 4-{[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}phenol by attachment of the phenolic oxygen of one molecule to the benzene ring of the second (ortho to the phenolic hydroxy group of the latter).


benzatropine

Tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to reduce parkinsonism and akathisia side effects of antipsychotic treatments.


oxolucidine B

An organonitrogen heterocyclic compound that is lucidine B in which the hydrogen at the 4a position of the dodecahydrobenzo[5,6]cyclohepta[1,2-b]pyridinyl moiety is substituted by a hydroxy group.


A tertiary amino compound that is p-methoxybenzylamine in which the hydrogens attached to the amino group have been replaced by methyl and 3-methyloxetan-3-yl groups.


N,N-dimethylformamide dimethyl acetal

An acetal obtained by formal condensation of N,N-dimethylformamide with methanol. N,N-dimethylformamide dimethyl acetal is a derivatisation agent used in gas-chromatography applications


MMP9 inhibitor I

A hydroxamic acid that is N-hydroxy-3-methylbenzamide in which the the hydrogens at positions 2 and 5 have been replaced by benzyl[(4-methoxyphenyl)sulfonyl]amino and (diethylamino)methyl groups, respectively. It is a cell-permeable, potent, selective, and reversible inhibitor of matrix metallopeptidase-9 (MMP-9, EC 3.4.24.35).