Refractory Low Grade Glioma

description: Low grade glioma that is resistant to treatment.


Oxyntic Gland Adenoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A benign epithelial neoplasm composed of columnar cells with differentiation to chief cells, parietal cells, or both, with a high rate of progression to adenocarcinoma (submucosal invasion). (WHO 2019)


name: Adult Non-T Non-B Acute Lymphoblastic Leukemia

description: Non-T non-B acute lymphoblastic leukemia that occurs during adulthood.


name: Stage IIB Digestive System Neuroendocrine Tumor AJCC v7

description: Stage IIB includes: T3, N0, M0.  T3: Stomach: tumor penetrates subserosa; jejunum/ileum: tumor invades through the muscularis propria into subserosal tissue without penetration of overlying serosa or invades into non-peritonealized tissues; ampulla/duodenum: tumor invades pancreas or retroperitoneum or into non-peritonealized tissues; colon or rectum: tumor invades through the muscularis propria into the subserosa, or into non-peritonealized pericolic or perirectal tissues. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Non-Obstructed Non-Refluxing Megaureter

description: A megaureter in which there is no obstruction at the ureterovesical junction and no vesicoureteral reflux.


name: Hodgkin's disease nodular sclerosis stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Resectable Melanoma

description: Melanoma that is amenable to surgical resection.


name: Endometrial Endometrioid Adenocarcinoma with an Undifferentiated Carcinomatous Component

description: A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of a component with undifferentiated malignant cells.


name: Stage III Gastric Neuroendocrine Tumor AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N0, M0); (T4, N1, M0). T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. T2: Tumor invading the muscularis propria or is greater than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Lugano Classification Stage I Childhood Hodgkin Lymphoma AJCC v8

description: Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


name: Myeloproliferative Neoplasm, BCR-ABL1 Negative

description: A myeloproliferative neoplasm characterized by the absence of Philadelphia chromosome and BCR-ABL1 fusion gene expression. This group includes polycythemia vera, essential thrombocythemia, and primary myelofibrosis.


Stage IB2 Cervical Cancer

description: Stage IB2 includes: T1b2, N0, M0.  T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: High Grade Esophageal Glandular Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal glandular epithelium.


Passive-Aggressive Personality Disorder

description: A disorder characterized by a pattern of indirect expression of hostility, including negativistic attitudes and passive resistance to demands for adequate performance in social and occupational situations.


Refractory Sarcoma

description: A sarcoma that does not respond to treatment.


Esophageal mucositis

description: An inflammatory process affecting the mucous membrane of the esophagus.


name: Non-Hodgkin Lymphoma with Variable Clinical Course

description: A non-Hodgkin lymphoma with variable clinical course.


Transferase Deficiency Galactosemia

description: A disorder characterized by the body's inability to metabolize galactose. This type of galactosemia is caused by germline mutations in the GALT gene which leads to the inhibition in the activity of the enzyme galactose-1-phosphate uridyl transferase.


YARSopathy

description: An autosomal recessive condition caused by mutation(s) in the YARS gene encoding tyrosine-tRNA ligase. It is characterized by a variable phenotype which may include poor growth, developmental delay, abnormal brain white matter, hearing loss, involuntary eye movements, progressive cholestatic liver disease, pancreatic insufficiency, hypoglycemia, anemia, intermittent excess of protein in urine, recurrent bloodstream infections, and chronic pulmonary disease.


name: Refractory Langerhans Cell Histiocytosis

description: Langerhans cell histiocytosis that does not respond to treatment.


Urinary Tract Fistula

description: An abnormal communication between any part of the urinary system and another organ or cavity.


name: Refractory Large Cell Neuroendocrine Carcinoma

description: Large cell neuroendocrine carcinoma that is resistant to treatment.


name: Mast Cell Leukemia with an Associated Myeloid Neoplasm

description: Mast cell leukemia associated with another clonal non-mast cell myeloid neoplasm (e.g., myelodysplastic syndrome, myeloproliferative neoplasm, and acute myeloid leukemia).


Extrahepatic bile duct cancer stage I

description: Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0).  T1: Tumor confined to the bile duct histologically.  T2: Tumor invades beyond the wall of the bile duct.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Stage IIB Prostate Cancer AJCC v8

description: Stage IIB includes: T1-2, N0, M0, PSA less than 20, Grade Group 2. T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. (AJCC 8th ed.)


Ocular Graft Versus Host Disease

description: Graft versus host disease occurring in the eye.


Liver Neuroendocrine Neoplasm

description: An extremely rare neoplasm with neuroendocrine differentiation that arises from the liver. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


Stage IB Uterine Corpus Cancer AJCC v7

description: Stage IB includes: T1b, N0, M0.  T1b: Tumor invades one-half or more of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Pancreatobiliary Carcinoma

description: A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater.


Refractory Acute Bilineal Leukemia

description: Acute bilineal leukemia that is resistant to treatment.


Refractory Endometrial Carcinoma

description: Endometrial carcinoma that is resistant to treatment


Brain Damage, Chronic

description: Encephalopathy that is persistent or long-standing in nature.


Disorder by Site

description: A term that refers to the classification of a disorder according to the anatomic site that is involved in the pathologic process.


Jejunal fistula

description: An abnormal communication between the jejunum and another organ or cavity.


name: Locally Advanced Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: Extrapulmonary large cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Malignant Lymphoma Follicular, Large Noncleaved Cell Type


Esophageal Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Childhood Fibrillary Astrocytoma

description: A fibrillary astrocytoma that occurs during childhood.


name: Cervical Florid Reactive Lymphoid Hyperplasia

description: A dense, superficial benign lymphoid cell proliferation in the cervix. It almost always occurs in premenopausal women. It is composed of a mixture of large and small lymphocytes including immunoblasts. Plasma cells and neutrophils are also present. Immunohistochemical studies reveal a mixture of B and T lymphocytes, and polytypic plasma cells.


Lentiginous Melanocytic Nevus

description: A nevus characterized by an intraepidermal proliferation of nested melanocytes along the basal epidermis.


Metastatic malignant neoplasm to ureter

description: A malignant neoplasm that has spread to the ureter from another anatomic site.


name: Lugano Classification Stage IE Hodgkin Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Resectable Dedifferentiated Liposarcoma

description: Dedifferentiated liposarcoma that is amenable to surgical resection.


Refractory Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that is resistant to treatment.


name: Venous Thrombosis Related to Vascular Access Complication

description: The formation of a thrombus in the vein as a direct result of an activity associated with vascular access.


Adult Epithelioid Hemangioendothelioma

description: An epithelioid hemangioendothelioma that occurs during adulthood.


Radial scar

description: A benign breast lesion characterized by the presence of fibrosis with stellate appearance in the parenchyma.  The lesions are often multiple and bilateral.  Grossly, the lesions are irregular and firm and resemble carcinoma.  Microscopically, the stellate lesions are composed of dense, hyalinized collagen.  Entrapped in the collagen are tubules.  There is no evidence of cytologic atypia.


Non-Encapsulated Neoplasm

description: A neoplasm that is non-capsulated.


name: Human Papillomavirus-Related Vaginal Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the vagina and is caused by human papillomavirus infection.


Non-ischemic Stroke

description: Any stroke that is not related to an obstructed blood vessel.


name: Recurrent Malignant Supratentorial Neoplasm

description: The reemergence of a malignant supratentorial neoplasm after a period of remission.


Delusional disorder, grandiose type

description: A subtype of delusional disorder characterized by the central delusional theme that the individual has special worth, power, knowledge, or a special relationship to a famous person or deity.


Miniature Adult Form of AHC

description: An autosomal recessive or sporadic form of adrenal hypoplasia congenita frequently associated with central nervous system anomalies including anencephaly and pituitary defects. Histologically the adrenal gland is distinguished by the absence of fetal adrenal cortex and the presence of a small amount of normal, permanent adult adrenal cortex.


Radiation-Induced Cerebritis

description: Cerebritis arising due to radiation therapy.


Congenital Coronary Artery Abnormality

description: A congenital condition referring to defects of the course and structure of the coronary arteries.


Adult Benign Cerebellar Neoplasm

description: A benign neoplasm of the cerebellum occurring in adults.


Episodic Ataxia Type 2

description: An autosomal dominant condition caused by mutation(s) in the CACNA1A gene, encoding voltage-dependent P/Q-type calcium channel subunit alpha-1A. It is characterized by paroxysms of vertigo, visual disturbance, dysarthria, and ataxia.


name: Endometrial Endometrioid Adenocarcinoma with Small Nonvillous Papillae


Stage IB Bone Cancer AJCC v8

description: Stage IB includes: (T2, N0, M0, G1 or GX); (T3, N0, M0, G1 or GX). T2: Tumor measuring more than 8 cm in greatest dimension. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Well differentiated, low grade. (AJCC 8th ed.)


Bone Marrow Suppression

description: A condition in which the production of red blood cells, white blood cells, and/or platelets by bone marrow stem cells is inhibited, usually as a side effect of treatment with various anti-cancer agents, radiation, or tumor development within the bone marrow.


Metastatic basal cell carcinoma

description: A carcinoma that arises from the basal cells and has metastasized to another anatomic site.


Stage III Cervical Cancer AJCC v9

description: Stage III includes: T3, N0, M0. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


AIDS Defining Illness

description: A disorder which indicates progression from HIV infection to acquired immunodeficiency syndrome (AIDS).


name: High Grade Conjunctival Melanocytic Intraepithelial Lesion

description: Conjunctival melanocytic intraepithelial lesion characterized by the presence of moderate to severe atypia.


Agenesis

description: A congenital abnormality resulting in the absence of an anatomical structure.


Stage I Cervical Cancer FIGO 2018

description: The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded). (FIGO 2018)


name: Grade II Glandular Intraepithelial Neoplasia


name: Recurrent Juvenile Myelomonocytic Leukemia

description: The reemergence of juvenile myelomonocytic leukemia after a period of remission.


description: An epithelioid hemangioendothelioma that occurs during childhood.


Locally Advanced Osteosarcoma

description: Osteosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Deformity

description: An anatomic abnormality that is either present at birth or appears later in life.


Stage IV Extrahepatic Bile Duct Cancer

description: Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 6th ed.)


Cytomegaloviral gastritis

description: Inflammation of stomach that is associated with cytomegalovirus.


Methotrexate-Associated Lymphoma

description: A non-Hodgkin or Hodgkin lymphoma that develops in patients who are immunosuppressed with methotrexate.


Transitory tachypnea of newborn

description: A respiratory disorder characterized by higher than normal respiratory rates among premature and cesarean section delivered neonates whose lungs have not fully matured. The cause is often excess fluid in the lungs, and resolution is aided by supplemental oxygen and sometimes, antibiotics.


name: T Acute Lymphoblastic Leukemia with TAL1 Rearrangement

description: T acute lymphoblastic leukemia characterized by the presence of TAL1 gene rearrangement.


name: Systemic lupus erythematosus, childhood onset

description: Systemic lupus erythematosus (SLE) diagnosed in individuals under the age of eighteen. Children frequently have multi-organ involvement and acute disease onset. Symptoms include fever, arthritis, skin lesions, anemia, and fatigue.


Benign neoplasm of female breast

description: A neoplasm that arises from the breast in females and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Early T-precursor lymphoblastic leukemia/lymphoma

description: T lymphoblastic leukemia/lymphoma in which the blasts have unique immunophenotypic and genetic characteristics suggesting only limited early T-cell differentiation.


Posterior Fossa Neoplasm

description: A neoplasm that arises from the posterior cranial fossa. Examples include meningiomas and medulloblastomas.


Recurrent Atypical Meningioma

description: The reemergence of atypical meningioma after a period of remission.


name: Transient Myocardial Dysfunction of Newborn

description: A condition in a newborn characterized by a temporary decrease in right ventricular and/or left ventricular output.


Hutch diverticulum

description: A congenital out pouching of the bladder involving the ureteral hiatus.


Obesity-Associated Insulin Resistance

description: Insulin resistance associated with obesity, which may be attributed in part to impaired insulin signaling in target tissues, or impaired insulin-stimulated glucose transport due to reduced expression of the glucose transporter protein 4.


Childhood Non-Ossifying Fibroma

description: A non-ossifying fibroma that occurs during childhood.


name: Clinical Stage IIC Cutaneous Melanoma AJCC v8

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Lymphoma, EBV-associated

description: Lymphoma that is caused by Epstein-Barr virus infection.


name: Stage I Anal Canal Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


name: T Acute Lymphoblastic Leukemia with LMO2 Rearrangement

description: T acute lymphoblastic leukemia characterized by the presence of LMO2 gene rearrangement.


Cutaneous Malignant Melanoma 2

description: An autosomal dominant genetic disorder caused by mutations in the CDKN2A gene, encoding cyclin-dependent kinase inhibitor 2A. The condition is characterized by cutaneous malignant melanoma associated with this genetic alteration.


Stage IVA Appendix Carcinoma AJCC v8

description: Stage IVA includes: (Any T, N0, M1a); (Any T, Any N, M1b, G1). N0: No regional lymph node metastasis. M1a: Intraperitoneal acellular mucin, without identifiable tumor cells in the disseminated peritoneal mucinous deposits. M1b: Intraperitoneal metastasis only, including peritoneal mucinous deposits containing tumor cells. G1: Well differentiated. (AJCC 8th ed.)


name: Follicle Stimulating Hormone Receptor Deficiency

description: Reduced or absent function of the receptor for follicle stimulating hormone associated with a mutation in the FSHR gene.


Adult L2 Acute Lymphoblastic Leukemia

description: L2 acute lymphoblastic leukemia that occurs during adulthood.


name: Central Nervous System SMARCB1/INI1-Deficient Tumor

description: A group of SMARCB1/INI1 deficient tumors that arise from the central nervous system. It includes highly aggressive and slow-growing tumors.


name: Clinical Stage 0 Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Malignant Lymphoma by Cell Type (Working Formulation)


name: Old Burn Scar-Related Cutaneous Melanoma

description: A cutaneous melanoma that arises in an old burn scar tissue.


name: Stage I Intermediate Grade Adult Non-Hodgkin's Lymphoma


Reactive Vascular Proliferation

description: A non-neoplastic proliferation of vessels in reaction to a process.


name: Recurrent Platinum-Resistant Fallopian Tube Carcinoma

description: The reemergence of platinum-resistant fallopian tube carcinoma after a period of remission.


Stage IV Vulvar Cancer AJCC v6

description: Stage IV includes: IVA (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4, Any N, M0); IVB (Any T, Any N, M1).  T4: Tumor invades any of the following: upper urethra bladder mucosa, rectal mucosa, or is fixed to the pubic bone.  N2: Bilateral regional lymph node metastasis.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 6th ed.)


Bladder Flat Urothelial Carcinoma

description: An in situ or invasive urothelial carcinoma that arises from the bladder wall and does not grow toward the hollow part of the bladder.


Intracranial Myeloid Sarcoma

description: A myeloid sarcoma that affects the meninges or the cerebral hemispheres.


Autosomal Recessive Disorder

description: An inherited disorder manifested only when two copies of a mutated gene are present.


name: High Grade Cervical Intraepithelial Neoplasia

description: Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of moderate or severe dysplastic changes.


Stage IIIA Vulvar Cancer AJCC v8

description: Stage IIIA includes: T1-T2, N1, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N1: Regional lymph node metastasis with one or two lymph node metastases each less than 5 mm, or one lymph node metastasis equal to 5 mm. M0: No distant metastasis. (AJCC 8th Ed.)


Fibrosarcoma non-metastatic

description: Fibrosarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


Cutaneous Neurocristic Hamartoma

description: A rare dermal and subcutaneous lesion that results from the aberrant development of neural crest-derived melanocytes.  It affects the head and neck with a predilection for the scalp.  It presents as a slowly enlarging multinodular plaque.  Morphologically is characterized by the presence of melanocytes and structures with schwannian differentiation in the dermis and subcutaneous tissue.


Anorectal infection

description: An infectious process affecting the anal area and the rectum.


Thrombocytopenic Disorder

description: A disorder of platelets characterized by a finding of low platelet concentrations (thrombocytopenia) typically below 50,000 platelets per microliter of blood.


name: Unspecified idiopathic peripheral neuropathy

description: Neuropathy, the cause of which is not known.


name: Oligometastatic Malignant Solid Neoplasm

description: A malignant solid neoplasm that has metastasized to a limited number of sites— existing in a state intermediate between localized disease and widespread metastatic disease.


name: Persistent Oligoarticular Juvenile Idiopathic Arthritis

description: Oligoarticular juvenile idiopathic arthritis that never involves more than four separate joints after six months.


Locally Advanced Prostate Carcinoma

description: A prostatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Cervical Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that arises from the cervix. This category includes neuroendocrine tumor grade 1, neuroendocrine tumor grade 2, and neuroendocrine carcinoma (small cell and large cell neuroendocrine carcinoma).


Childhood Neuroendocrine Tumor

description: A neuroendocrine tumor that occurs during childhood.


name: Locally Advanced Non-Muscle Invasive Bladder Carcinoma

description: Non-muscle invasive bladder carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IA Uterine Corpus Cancer AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Uterine corpus carcinoma or carcinosarcoma with tumor limited to the endometrium or invading less than half the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Pediatric Viral Infection

description: A viral infection that occurs during infancy, childhood or adolescence.


name: Immune Checkpoint Inhibitor-related Myocarditis

description: Myocarditis associated with the therapeutic use of an immune checkpoint inhibitor.


name: Meningeal Melanocytoma of Intermediate Grade

description: A circumscribed meningeal melanocytic neoplasm with bland histological features and increased mitotic activity or invasion of the central nervous system.


name: Fetus Small for Gestational Age with Abdominal Circumference Less than Tenth Percentile

description: A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and whose abdominal circumference falls below the tenth percentile.


name: Refractory Abdominal Neuroendocrine Neoplasm

description: An abdominal neuroendocrine neoplasm that does not respond to treatment.


name: Vaginal Large Cell Neuroendocrine Carcinoma

description: A rare, aggressive neuroendocrine carcinoma that arises from the vagina and is characterized by the presence of malignant cells with abundant cytoplasm, large nuclei, and prominent nucleoli.


Childhood Diffuse Large Cell Lymphoma

description: A diffuse large cell lymphoma occurring in children.


name: Recurrent EBV-Related Lymphoproliferative Disease with Primary Immunodeficiency

description: The reemergence of EBV-associated lymphoproliferative disease with primary immunodeficiency after a period of remission.


name: Retinoblastoma by AJCC v8 Pathologic Stage

description: A term that refers to the pathologic staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition.


name: Diffuse Midline Glioma with EZHIP Overexpression

description: A diffuse midline glioma, H3 K27-altered, characterized by the presence of EZHIP overexpression.


Latent Infection

description: A period in which the infection is present in the host without producing overt symptoms.  (from Online Medical Dictionary)


name: Testicular Sclerosing Sertoli Cell Tumor

description: A rare testicular Sertoli cell tumor characterized by the presence of neoplastic tubules that are surrounded by a dense fibrotic stroma.


Recurrent Carcinoma

description: The reemergence of a carcinoma after a period of remission.


Stage IVA Uterine Corpus Cancer AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Uterine corpus carcinoma or carcinosarcoma with tumor invading the bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (from AJCC 8th Ed.)


Hormone Therapy Refractory Neoplasm

description: A neoplasm that does not respond to hormone therapy.


Arbovirus hemorrhagic fever

description: A group of viral illnesses that are vectored by arthropods, and that are characterized by increased susceptibility to bleeding diatheses.


Locally Advanced Cutaneous Melanoma

description: Cutaneous melanoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Malignant Intracranial Neoplasm

description: A malignant neoplasm involving the intracranial space.


name: Cutaneous Acute Graft versus Host Disease

description: Skin manifestations of acute graft versus host disease, which typically presents as an erythematous maculopapular rash involving the face, ears, palms, and soles that may spread to the trunk and evolve to erythroderma.


name: Chronic Active EBV Infection of T-and NK-Cell Type, Systemic Form

description: An EBV-positive T-cell/NK-cell lymphoproliferative disorder characterized by repeated infectious mononucleosis-like symptoms, a very high titer of anti-EBV antibodies, and high levels of Epstein-Barr virus nucleic acids. Patients often develop progressive cellular and humoral immunodeficiency with pancytopenia and hypogammaglobulinemia.


name: Deep Venous Thrombosis Related to COVID-19

description: Deep vein thrombosis in a patient with probable or confirmed acute COVID-19.


name: Clinical Stage IA Cutaneous Melanoma AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Breast Neurofibroma

description: A neurofibroma that arises from the breast.


name: Advanced Cutaneous Melanoma of the Extremity

description: Cutaneous melanoma of the upper or lower extremity that has spread extensively to other anatomic sites or is no longer responding to treatment.


Radiation-induced fibrous mediastinitis

description: Fibrous mediastinitis arising due to radiation therapy.


name: Recurrent Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: The reemergence of extrapulmonary small cell neuroendocrine carcinoma after a period of remission.


Sessile Serrated Adenoma/Polyp

description: Polyps that arises from the large intestine and the appendix. They are characterized by the presence of serrated glands and the absence of generalized dysplasia.


name: Childhood Acute Myeloid Leukemia with Minimal Differentiation

description: An acute myeloid leukemia with minimal differentiation occurring in children.


name: Stage III Adult Diffuse Small Cleaved Cell Lymphoma

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


name: Childhood Central Nervous System Neoplasm

description: A benign or malignant neoplasm of the brain, spinal cord, or meninges occurring in children.  Representative examples include posterior fossa astrocytoma, optic pathway glioma, medulloblastoma, ependymoma, and craniopharyngioma.


Primary malignant neoplasm

description: A malignant tumor at the original site of growth.


Recurrent Adnexal Carcinoma

description: The reemergence of adnexal carcinoma after a period of remission.


Metastatic Adnexal Carcinoma

description: Adnexal carcinoma that has spread from the original site of growth to other anatomic sites.


Stage IIB Osteosarcoma AJCC v7

description: Stage IIB includes: T2, N0, M0, G3, G4.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Fallopian Tube Metaplastic Papillary Lesion

description: A rare benign lesion that arises in the fallopian tubes of postpartum women. It is characterized by intratubal luminal papillary proliferation lined by columnar cells with abundant eosinophilic cytoplasm. Significant cytologic atypia and mitoses are absent. Mucinous and oncocytic metaplasia may be present.


Pancreatic Cancer by AJCC v8 Stage

description: A term that refers to the staging of exocrine pancreatic cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to pancreatic ductal adenocarcinoma, acinar cell carcinoma, intraductal papillary mucinous neoplasm with associated invasive carcinoma, intraductal tubulopapillary neoplasm with associated invasive carcinoma, colloid carcinoma, mucinous cystic neoplasm with associated invasive carcinoma, solid pseudopapillary neoplasm, large cell neuroendocrine carcinoma, small cell neuroendocrine carcinoma, and pancreatoblastoma. Well-differentiated neuroendocrine tumors are not staged using this staging system. (from AJCC 8th Ed.)


Primary osteosarcoma of bone

description: A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the bone. It usually involves the long bones and predominantly affects adolescents and young adults. Pain and a palpable mass are the most frequent clinical sign and symptom. It may spread to other anatomic sites, particularly the lungs.


name: FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting 5% or less solid non-glandular, non-squamous growth.


Chlamydia psittaci infection

description: A bacterial infection caused by Chlamydophila psittaci. Humans are infected by handling sick birds. The Chlamydiae cause respiratory infection manifests with fever, malaise, cough, dyspnea, sore throat, photophobia and headaches.


Clinical Test Result

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition.


Stage IVB Cervical Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (including peritoneal spread or involvement of the supraclavicular, mediastinal, or distant lymph nodes; lung; liver; or bone). (from AJCC 8th Ed.)


name: Recurrent Adult Diffuse Small Cleaved Cell Lymphoma

description: The reemergence of adult diffuse small cleaved cell lymphoma after a period of remission.


Advanced Neuroendocrine Tumor

description: A neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Gastric Carcinoma

description: Gastric carcinoma that does not respond to treatment.


Solid pseudopapillary neoplasm

description: A low-grade malignant neoplasm that arises from the exocrine pancreas. Rare cases arising from ectopic pancreatic tissue in the ovary have also been described. It is characterized by the presence of uniform cells that form solid and pseudopapillary patterns, cystic changes, and hemorrhage. It usually presents as an encapsulated, solitary, and lobulated mass. It occurs predominantly in young women. Complete removal of the tumor is curative in the majority of cases.


IOL dislocation

description: Displacement of the intraocular lens from the visual axis.


name: Low-CSD Melanoma, Superficial Spreading Melanoma Subtype

description: A cutaneous melanoma that develops on sun exposed sites with low cumulative sun damage (CSD). It is characterized by a prominent junctional and intraepidermal component with intraepidermal proliferation of individual atypical melanocytes and formation of nests of atypical melanocytes along the dermal-epidermal junction. The dermal component is composed of atypical melanocytes that fail to mature. The atypical melanocytes have large nuclei, prominent nucleoli, and eosinophilic or lightly pigmented cytoplasm. It is the most common melanoma subtype in the Western world.


Stage IIA1 Cervical Cancer FIGO 2018

description: Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement, less than 4 cm in greatest dimension. (FIGO 2018)


Refractory Giant Cell Glioblastoma

description: Giant cell glioblastoma that is resistant to treatment.


Genitourinary System Carcinoma

description: A carcinoma arising from the genitourinary system. Representative examples include kidney carcinoma, bladder carcinoma, prostate carcinoma, endometrial carcinoma, cervical carcinoma, and ovarian carcinoma.


Anti-D Hemolytic Disease of the Newborn

description: A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of antibodies from a mother to the child via the placenta against the D antigen, the most common Rhesus factor.


Non-Neoplastic Thoracic Disorder

description: A non-neoplastic disorder that affects the thorax and/or the organs of the thoracic cavity.  Representative examples include pleural infection, mediastinitis, pneumonia, and chronic obstructive pulmonary disease.


name: Regional Urothelial Carcinoma of the Renal Pelvis and Ureter

description: Urothelial carcinoma of the renal pelvis or ureter that has spread to adjacent tissues and/or regional lymph nodes but not to distant anatomic sites.


Sarcoma of the Extremity

description: A sarcoma that arises from the soft tissues or bones of the upper or lower extremity.


Stoma Site Infection

description: An infectious process affecting a surgically created opening in the surface of the body.


Recurrent Urinary System Carcinoma

description: Reemergence of a urinary system carcinoma after a period of remission.


Severe Mosquito Bite Allergy

description: An EBV-positive NK-cell lymphoproliferative disorder characterized by high fever and intense local skin symptoms, including erythema, bullae, ulcers, skin necrosis, and deep scarring following mosquito bites. Patients have NK-cell lymphocytosis in the peripheral blood and an increased risk of developing hemophagocytic syndrome and progressing into overt NK/T-cell lymphoma or aggressive NK-cell leukemia in the longstanding clinical course. (WHO 2017)


name: Classical Hodgkin lymphoma type posttransplant lymphoproliferative disorder

description: A lymphoproliferative disorder that fulfills the criteria for classic Hodgkin lymphoma and arises as a result of post-transplant immunosuppression therapy. It is most often seen in renal transplant patients.


Unresectable Bladder Adenocarcinoma

description: Bladder adenocarcinoma that is not amenable to surgical resection.


Stage I Gallbladder Cancer AJCC v7

description: Stage I includes: T1, N0, M0. T1: Tumor invades lamina propria or muscular layer.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Metastatic Digestive System Carcinoma

description: A carcinoma that arises from the gastrointestinal system and has metastasized to other anatomic sites.


Unresectable Meningioma

description: A meningioma that is not amenable to surgical resection.


name: Stage IV Adult Diffuse Large Cell Lymphoma

description: Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)


Spinal Cord Hamartoma

description: A hamartoma that occurs in the spinal cord.


Delusional disorder, unspecified type

description: A subtype of delusional disorder applied when the dominant delusional theme cannot be clearly determined.


name: Childhood Cancer Stage by Toronto Guidelines v2

description: A term that refers to the staging of childhood cancers following the rules of the Toronto guidelines v2, 2019. The guidelines were developed to address the lack of consistent information on childhood cancer staging in population registries and are not intended to replace staging systems in clinical use. They include a two-tiered approach that provides less detailed criteria for registries with limited resources and/or limited data access (Tier 1) and more detailed criteria for better-resourced registries (Tier 2). They apply to acute lymphoblastic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, neuroblastoma, renal malignant tumors except renal cell carcinoma, rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, malignant bone tumors, retinoblastoma, hepatoblastoma, testicular germ cell tumors, ovarian germ cell tumors, astrocytoma, medulloblastoma and ependymoma. The following changes were noted to the original classification (v1, 2014): a staging system was no longer considered appropriate for acute myeloid leukemia; all renal tumors, with the exception of renal cell carcinomas, should use the endorsed staging systems for Wilms tumor; staging systems for osteosarcoma and Ewing sarcoma were combined into a single recommendation for all malignant bone tumors; a staging system was endorsed for astrocytomas; the S category (serum tumor markers) was confirmed as an integral part of TNM staging for testicular cancer in Tier 2 recommendations; and PRETEXT number was added to Tier 2 recommendations for hepatoblastoma. (adapted from Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Lymphoma, AIDS-Related

description: An aggressive lymphoma that develops in HIV-positive patients.  There is a significant increase in the incidence of lymphomas associated with the AIDS epidemic.  These lymphomas are usually extranodal, most often express a B-cell phenotype and morphologically are classified as Burkitt, diffuse large B-cell, and Hodgkin lymphomas.  The prognosis is closely related to the severity of immunodeficiency.


name: Stage IV Appendix Neuroendocrine Tumor AJCC v7

description: Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


Cervical Neuroendocrine Tumor

description: A well-differentiated neuroendocrine neoplasm that arises from the cervix. It may be classified as G1 (low grade) or G2 (intermediate grade) neuroendocrine tumor.


name: Gastric Antrum Carcinoma In Situ AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial tumor without invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Primary Cutaneous Peripheral T-Cell Lymphoma, Rare Subtype

description: A rare, mature T-cell lymphoma arising from the skin.


Locally Advanced Urothelial Carcinoma

description: A urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Urothelial Carcinoma, High Grade

description: Urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


Resectable Malignant Solid Neoplasm

description: Malignant solid neoplasm that is amenable to surgical resection.


Congenital Vena Cava Abnormality

description: An abnormality of the superior or inferior vena cava that is present at birth. Representative examples include persistent left superior vena cava, absence of infrarenal inferior vena cava, or absence of the entire inferior vena cava.


Post-Treatment Lyme Disease Syndrome

description: A constellation of symptoms lasting months to years reported by some Lyme disease patients who had undergone previous antibiotic therapy.


name: Childhood Langerhans Cell Histiocytosis with Risk Organ Involvement

description: Langerhans cell histiocytosis that occurs during childhood and involves the bone marrow, spleen, liver, or lung.


Prostate Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the prostate gland.  Representative examples include acute and chronic prostatitis.


Stage IB Pancreatic Cancer AJCC v8

description: Stage IB includes: T2, N0, M0. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metanephric stromal tumor

description: A rare benign renal neoplasm composed of moderately cellular spindle cells. It occurs mostly in infancy and childhood.


name: Recurrent Glioneuronal and Neuronal Tumors

description: The reemergence of glioneuronal and neuronal tumors after a period of remission.


Lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Miscellaneous Neoplasm

description: A benign or malignant neoplasm which is not further characterized.


name: Esophageal Adenocarcinoma by AJCC v8 Pathologic Stage

description: A term that refers to the pathologic staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Scrotal hernia

description: The protrusion of abdominal cavity contents into the scrotal sac.


Stage I Cervical Cancer AJCC v6 and v7

description: Stage I includes: I (T1, N0, M0); IA (T1a, N0, M0); IA1 (T1a1, N0, M0); IA2 (T1a2, N0, M0); IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1: Cervical carcinoma confined to uterus (extension to corpus should be disregarded). T1a: Invasive carcinoma diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. T1a1: Measured stromal invasion 3.0 mm or less in depth and 7.0 or less horizontal spread.  T1a2: Measured stromal invasion more than 3.0mm and not more than 5.0 mm with a horizontal spread 7.0mm or less. T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


COVID-19-Associated Encephalitis

description: Encephalitis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Childhood Neurofibroma

description: A neurofibroma that occurs during childhood.


name: Recurrent Malignant Nongerminomatous Germ Cell Tumor

description: The reemergence of a malignant nongerminomatous germ cell tumor after a period of remission.


PTEN Deficiency

description: A condition of decreased or absent presence or activity of phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, which is associated with multiple hamartoma syndrome (Cowden syndrome) and increased risk for development of several types of malignant cancers, including head and neck, breast, lung and prostate cancer and glioblastoma.


name: Refractory Malignant Male Reproductive System Neoplasm

description: Malignant male reproductive system neoplasm that is resistant to treatment.


name: Ampulla of Vater Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region. The mitotic count is 2-20 per 10 HPF.


Advanced Lymphoma

description: Lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IIC Appendix Carcinoma AJCC v7

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades other organs or structures.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Cervical Cancer by AJCC v9 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 9th edition. This staging system applies to carcinomas and carcinosarcomas. It does not apply to sarcomas, lymphomas, and melanomas. Sarcomas are staged according to the corpus uteri classification for sarcomas. Lymphomas are staged according to Hodgkin and non-Hodgkin lymphoma classification. Melanomas are not staged. (from AJCC 9th Ed.)


Childhood Schwannoma

description: A schwannoma that occurs during childhood.


name: Digestive System Neuroendocrine Tumor by AJCC v7 Stage

description: A term that refers to the staging of a digestive system neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system.


name: Childhood Hodgkin Lymphoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood Hodgkin lymphoma according to the Toronto childhood cancer staging guidelines v2. Staging is the same for both tiers (tier 1 and 2).


Stage IIA1 Cervical Cancer AJCC v8

description: Stage IIA1 includes: T2a1, Any N, M0. T2a1: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Refractory Neuroendocrine Carcinoma

description: Neuroendocrine carcinoma that does not respond to treatment.


Cutaneous Melanoma by AJCC v8 Stage

description: A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system. This staging system does not apply to melanoma of the conjunctiva, melanoma of the uvea, mucosal melanoma arising in the head and neck, and mucosal melanoma of the urethra, vagina, rectum, and anus. (from AJCC 8th Ed.)


Dermal nerve sheath myxoma

description: A usually painless, slow growing benign tumor that most often arises from the extremities. It is characterized by the presence of abundant myxoid matrix and small epithelioid neoplastic Schwann cells.


Congenital Amegakaryocytosis

description: A rare disorder of infancy characterized by marked reduction or absence of megakaryocytes and thrombocytopenia.


Gastroesophageal Junction Carcinoma

description: A carcinoma that arises from the gastroesophageal junction. The vast majority of cases are adenocarcinomas. Rare cases are neuroendocrine carcinomas.


Cannabis dependence, episodic

description: Physical and psychological dependence on the drug cannabis, which is associated with a pattern of episodic use.


name: Metastatic Pancreatic Neuroendocrine Neoplasm

description: A pancreatic neuroendocrine neoplasm that has spread from its original site of growth to another anatomic site.


name: Myelodysplastic Chronic Myelomonocytic Leukemia

description: Chronic myelomonocytic leukemia characterized by the absence of a markedly elevated white blood cell count in the peripheral blood.


Poroid Hidradenoma

description: A poroma characterized by the presence of a single or several nodules of neoplastic cells forming solid and cystic areas in the dermis.


name: Non-Neoplastic Hematologic and Lymphocytic Disorder

description: A non-neoplastic disorder that arises from hematopoietic and lymphoid cells. It is characterized by the absence of a clonal cellular component. It rarely progresses to a malignant neoplasm.


Stage II Urethral Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: For male penile urethra and female urethra: Tumor invades any of the following: corpus spongiosum, periurethral muscle. For prostatic urethra: Tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Mesonephric Hyperplasia

description: A hyperplasia of the mesonephric cells.


name: Stage IB Ampulla of Vater Cancer AJCC v7

description: Stage IB includes: T2, N0, M0. T2: Tumor invades the duodenal wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Contact lens overwear syndrome (disorder)

description: Ocular pain which may be very intense, accompanied by corneal epithelium damage, conjunctival injection, lacrimation, blepharospasm, photophobia and hazy vision following corneal edema caused by overwear of contact lenses, principally the PMMA type.


neuroendocrine carcinoma of anal canal

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Acral Melanoma

description: A cutaneous melanoma that arises from the palms, soles, and nails.


name: Lugano Classification Limited Stage Adult Hodgkin Lymphoma AJCC v8

description: Limited stage adult Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Unresectable Adenoid Cystic Carcinoma

description: Adenoid cystic carcinoma that is not amenable to surgical resection.


name: AIDS-Related Diffuse Small Cleaved Cell Lymphoma

description: A non-Hodgkin lymphoma occurring in HIV-positive patients.  It is composed of small cleaved lymphocytes.


name: Bile Duct Mucinous Cystic Neoplasm, Low Grade

description: A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of mild atypia.


Childhood Gliosarcoma

description: A gliosarcoma that occurs during childhood.


name: Undifferentiated Carcinoma of Unknown Primary

description: An undifferentiated carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified.


Parapsoriasis lichenoides

description: A rare condition that stimulated chronic radiodermatitis.  It is considered a variant of mycosis fungoides.


name: acute undifferentiated leukemia in relapse

description: The reemergence of acute undifferentiated leukemia after a period of remission.


Sweat Gland Tubular Carcinoma

description: An aggressive adenocarcinoma that arises from the sweat glands. It usually presents as a firm, erythematous nodular lesion in the axilla. Morphologically, it is characterized by the presence of tubular structures and apocrine differentiation.


Stage III Vulvar Cancer AJCC v8

description: Stage III includes: T1-T2, N1-N2c, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N1: Regional lymph node metastasis with one or two lymph node metastases each less than 5 mm, or one lymph node metastasis equal to 5 mm. N2a: Three or more lymph node metastases each less than 5 mm. It includes micrometastasis, N2mi. N2b: Two or more lymph node metastases equal to 5 mm. N2c: Lymph node(s) metastasis with extranodal extension. M0: No distant metastasis. (AJCC 8th Ed.)


Parathyroid chief-cell hyperplasia

description: A hyperplasia of the chief cells of the parathyroid gland.


name: Recurrent Platinum-Sensitive Endometrial Carcinoma

description: The reemergence of platinum-sensitive endometrial carcinoma after a period of remission.


Balloon cell nevus

description: An uncommon variant of melanocytic nevus. It presents as a small pigmented skin lesion. It is characterized by the presence of large melanocytes with clear, foamy or finely vacuolated cytoplasm. It may recur if it is not completely excised.


Sacral Myelocele

description: Herniation of spinal cord tissue and meninges through a defect in the sacral region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


Metastatic Neoplasm to the Bladder

description: The spread of a malignant neoplasm to the urinary bladder wall from an adjacent or distant anatomic site.


name: Stage y-III Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Incomplete excision of the tumor (gross or microscopic extension beyond the resection margins). Involved abdominal lymph nodes, including necrotic tumor or chemotherapy-induced changes. Tumor rupture before or intraoperatively. Tumor has penetrated the peritoneal surface. Tumor thrombi present at resection margins. Surgical biopsy prior to resection (does not include needle biopsy). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Lugano Classification Stage III Adult Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Acute Submassive Pulmonary Embolism

description: Acute pulmonary embolism with evidence of right ventricular dysfunction, but not associated with systemic hypotension.


name: Enterochromaffin-Like Cell Neuroendocrine Tumor G1

description: A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) arising from the gastrointestinal tract. It is characterized by the presence of enterochromaffin-like type granules in the neoplastic cells.


name: Invasive Conventional Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by the presence of malignant cells forming trabeculae, cords, sheets, and nests. Individual malignant cells are also present.


Stage IVB Gallbladder Cancer AJCC v7

description: Stage IVB includes: (Any T, N2, M0); (Any T, Any N, M1).  N2: Metastases to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes.  M0: No distant metastasis.  M1: Distant metastasis. (from AJCC 7th Ed.)


name: Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Metastatic Malignant Neoplasm in the Female Reproductive System

description: The spread of a malignant neoplasm to the female reproductive system from an adjacent or distant anatomic site.


name: IgM Monoclonal Gammopathy of Undetermined Significance, Not Otherwise Specified

description: A subtype of IgM monoclonal gammopathy of undetermined significance that includes cases associated with MYD88 mutation and cases associated with the presence of monoclonal B-lymphocytes without the presence of abnormal lymphoplasmacytic aggregates that are diagnostic of lymphoplasmacytic lymphoma or other small B-lymphocytic neoplasms.


Chronic Total Occlusion Vessel

description: A longstanding, complete blockage of a vessel. (ACC)


name: Malignant Germinative Follicular Epithelium Neoplasm

description: A malignant neoplasm that arises from germinative follicular epithelial cells.


name: Ampulla of Vater Cancer by AJCC v7 Stage

description: A term that refers to the staging of ampulla of Vater cancer according to the American Joint Committee on Cancer, 7th edition.


name: Recurrent Childhood Central Nervous System Neoplasm

description: The reemergence of central nervous system neoplasm in childhood after a period of remission.


COVID-19-Associated Stroke

description: Cerebrovascular accident caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Stage 0 Uterine Corpus Cancer

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis.  This staging applies to carcinomas and carcinosarcomas.  FIGO no longer includes Stage 0 (Tis). (AJCC 7th ed.)


name: Metastatic Digestive System Neuroendocrine Tumor G2

description: Digestive system neuroendocrine tumor G2 that has spread from its original site of growth to another anatomic site.


Stage IVB Cervical Cancer FIGO 2018

description: The cervical carcinoma has spread to distant organs. (FIGO 2018)


name: Cervical Papillary Squamous Cell Carcinoma

description: A human papillomavirus-related cervical squamous cell carcinoma characterized by the presence of papillary structures covered with epithelial cells which show features of cervical intraepithelial neoplasia. The malignant cellular component below the papillary structures is a squamous cell carcinoma.


name: Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: An undifferentiated high grade pleomorphic sarcoma that arises from the bone and occurs during childhood.


Refractory Primary Amyloidosis

description: Primary amyloidosis that does not respond to treatment.


Plasma Kallikrein Deficiency

description: A coagulation disorder characterized by the partial or complete absence of plasma-type kallikrein activity in the blood.


name: Childhood Refractory Malignant Solid Neoplasm

description: A childhood malignant solid neoplasm that does not respond to treatment.


Factor VII Inactivation

description: Presence of inactivating antibodies to factor VII in the blood.


Adult Hodgkin Lymphoma

description: Hodgkin lymphoma occurring in adults.


Signet Ring Cell/Histiocytoid Carcinoma

description: A rare aggressive adnexal carcinoma preferentially affecting the eyelid and histopathologically resembling a metastatic lobular carcinoma of the breast and/or some adenocarcinomas arising in the gastrointestinal tract. (WHO 2018)


benign mature teratoma of pancreas

description: A mature teratoma that arises from the pancreas.


name: Recurrent Low Grade Adult Non-Hodgkin's Lymphoma


Early Prosthetic Valve Endocarditis

description: Prosthetic valve endocarditis that occurs days to weeks after surgery.


Advanced Pancreatic Carcinoma

description: Pancreatic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Meningohydroencephalocele

description: A congenital neural tube closure defect resulting in protrusion of the brain, the meninges, and the ventricular system through an opening in the skull, usually involving the squamous part of the occipital bone..


Skin squamous cell carcinoma metastatic

description: Squamous cell carcinoma of the skin which has spread to other anatomic sites.


Refractory Cervical Adenocarcinoma

description: Cervical adenocarcinoma that is resistant to treatment.


High Grade Osteosarcoma

description: An aggressive osteosarcoma with high-grade morphological features. This category includes high-grade surface osteosarcoma and conventional osteosarcoma.


name: Poorly Differentiated Prostate Adenocarcinoma

description: An invasive prostate adenocarcinoma characterized by the presence of poorly differentiated malignant cells.


Invasive Nested Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by a nested growth pattern.


Sickle cell-thalassemia disease

description: Hemolytic anemia, in which patients are heterozygous for both the sickle cell gene and a thalassemia gene.


Unfavorable Hodgkin Lymphoma

description: A Hodgkin lymphoma with unfavorable prognosis.


Primary Parathyroid Gland Hyperplasia

description: Parathyroid gland hyperplasia that occurs in the absence of physiological stimuli.


Stage IVB Osteosarcoma AJCC v7

description: Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N1: Regional lymph node metastasis.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Infarction of spinal cord

description: Ischemic necrosis of the spinal cord caused by occlusion of the arteries that supply blood to the spinal cord. Signs and symptoms include intermittent back pain, pain in the legs, paralysis, and incontinence.


Hereditary Angioedema Types I and II

description: Autosomal dominant inherited disorders characterized by abnormalities of C1 inhibitor. Patients present with swelling of the skin, subcutaneous tissues, and mucosa sites. In type I hereditary angioedema, the plasma levels of C1 inhibitor are decreased. In type II hereditary angioedema, the C1 inhibitor is dysfunctional and its plasma levels may be normal or elevated.


Uterine Corpus Cancer by AJCC v7 Stage

description: A term that refers to the staging of uterine corpus cancer (carcinoma or carcinosarcoma) according to the American Joint Committee on Cancer, 7th edition.


Recurrent Malignant Bone Neoplasm

description: Reemergence of a malignant bone neoplasm after a period of remission.


name: Gallbladder Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma

description: A mucinous cystic neoplasm that arises from the gallbladder and it is associated with an invasive carcinomatous component.


name: Sporadic Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is not caused by inherited genetic mutations.


Carcinoid tumor of the liver

description: An extremely rare, well differentiated neuroendocrine neoplasm arising from the liver. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation.


name: TdT Positive Acute Lymphoblastic Leukemia


Adult Gliosarcoma

description: A gliosarcoma occurring in adults.


Stage II Ureter Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor invades the muscularis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Mosquito-borne hemorrhagic fever

description: A group of viral illnesses that are vectored by mosquitoes, and that are characterized by increased susceptibility to bleeding diatheses.


Hypomyelinating Leukodystrophy-22

description: An autosomal dominant condition caused by mutation(s) in the CLDN11 gene, encoding claudin-11.  It is characterized by global developmental delay, mild impaired intellectual development, limited ability to walk, and hypomyelinating leukodystrophy on MRI.


name: congenital renal arteriovenous malformation

description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the kidney.


Craniotubular Hyperostosis

description: A group of sclerosing bone dysplasias characterized by pronounced sclerosis of the cranial vault and the long bones, resulting in increased cortical bone density. Most cases are caused by mutation(s) in the SOST or LRP5 genes, encoding sclerostin and low-density lipoprotein receptor-related protein 5, respectively. Other genes have been implicated, and some cases have been described, but do not yet have identified genetic mutations.


name: Stage IB Gestational Trophoblastic Tumor AJCC v7

description: Stage IB includes: T1, M0, Risk factors: high risk.  T1: Tumor confined to uterus.  M0: No distant metastasis.  (AJCC 7th ed.)


Disseminated carcinoma

description: Carcinoma that is spread throughout the body.


Insomnia due to organic factors

description: Insomnia as a result of a physiological cause.


Congenital kyphosis

description: An abnormally increased curvature of the thoracic portion of the spine that is present at the time of birth.


name: Human Papillomavirus-Related Malignant Neoplasm in AIDS Patient

description: A malignant neoplasm caused by human papillomavirus in an a patient with a history of AIDS.


Metastatic Malignant Solid Neoplasm

description: A malignant solid neoplasm that has spread from its original site of growth to another anatomic site.


name: Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Alkylating Agent-Related Acute Myeloid Leukemia

description: Acute myeloid leukemia occurring as late complication of prior therapy with alkylating agents.


name: Invasive Bladder Large Nested Urothelial Carcinoma

description: A rare invasive bladder urothelial carcinoma characterized the presence of medium to large nests of malignant cells.


Fibromyxolipoma

description: A benign well-circumscribed tumor composed of mature adipocytes, characterized by areas of abundant fibrous tissue and extensive myxoid change.


Salt-Wasting 21-Hydroxylase Deficiency

description: A classic form of congenital adrenal hyperplasia characterized by complete absence of 21-hydroxylase activity resulting in deficiency of glucocorticoids and mineralocorticoids accompanied by androgen excess causing virilization in female infants. Mineralocorticoid deficiency results in renal salt-wasting, and if untreated, hyponatremia, hyperkalemia, and shock.


Appendix Mucinous Cystadenoma

description: A cystically dilated epithelial neoplasm arising from the appendix.  It is characterized by the presence of a cystic structure that is filled with mucus.


name: Hodgkin's disease, nodular sclerosis of lymph nodes of multiple sites

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Metastatic Bladder Small Cell Neuroendocrine Carcinoma

description: Bladder small cell neuroendocrine carcinoma that has spread to another anatomic site.


name: Prostate Cancer by Whitmore-Jewett Stage

description: A term that refers to the staging of prostate carcinoma according to the Whitmore-Jewett staging system.


name: Clinical Stage II Cutaneous Melanoma AJCC v8

description: Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA

description: Chronic eosinophilic leukemia characterized by the rearrangement of the PDGFRA gene, most often resulting in the formation of FIP1L1-PDGFRA fusion transcripts.


name: Childhood Acute Lymphoblastic Leukemia by Toronto Guidelines v2

description: A term that refers to the staging of childhood acute lymphoblastic Leukemia according to the Toronto childhood cancer staging guidelines v2.


Angiosarcoma recurrent

description: The reemergence of angiosarcoma after a period of remission.


Glioblastoma by Gene Expression Profile

description: Classification of glioblastoma into molecular subtypes as defined by gene expression profiling.


Metastatic Midgut Neuroendocrine Tumor

description: A midgut neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


Stage III Anal Cancer AJCC v8

description: Stage III includes: IIIA: (T1, N1, M0); (T2, N1, M0); IIIB: (T4, N0, M0); IIIC: (T3, N1, M0); (T4, N1, M0). T1: Tumor 2 cm or smaller. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. T3: Tumor larger than 5 cm. T4: Tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder. N0: No regional lymph node metastasis. N1: Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes. M0: No distant metastasis. (AJCC 8th ed.)


Primary acquired melanosis

description: A spectrum of neoplastic changes that occur in the conjunctiva and range from melanocytic hyperplasia through degrees of atypia to melanoma in situ. The lesions are generally unilateral but often multifocal and appear as flat, irregular brown discolorations of the conjunctiva. They usually affect middle-aged and elderly Caucasians. (WHO 2018)


Meningeal Gliomatosis

description: Diffuse or multifocal infiltration of the meninges by malignant glioma.


Gallbladder Goblet Cell Adenocarcinoma

description: An invasive mixed adenoneuroendocrine carcinoma of the gallbladder characterized by the presence of neoplastic signet-ring cells resembling goblet cells of the intestine.


name: High Grade Prostatic Intraepithelial Neoplasia, Small Cell Neuroendocrine Variant

description: High grade prostatic intraepithelial neoplasia characterized by the presence of small neuroendocrine cells in the affected glands.


name: Locally Advanced Ampulla of Vater Carcinoma

description: Carcinoma that arises from the ampulla of Vater and has spread to nearby tissues or lymph nodes.


name: Monomorphic Post-Transplant Lymphoproliferative Disorder

description: A clonal lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed lymphocytes or plasma cells.  It includes two variants: monomorphic B-cell and monomorphic T/NK cell post-transplant lymphoproliferative disorders.


Zoonotic Spillover

description: Transmission of an infectious disease from a reservoir vertebrate population with a high pathogen prevalence coming into contact with a naive human population.


name: Pathologic Stage IV Retinoblastoma AJCC v8

description: Stage IV includes: Any pT, Any N, cM1 or pM1, Any H. cM1: Distant metastasis without microscopic confirmation. pM1: Distant metastasis with microscopic confirmation. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


EBV-Associated Smooth Muscle Tumor

description: A rare smooth muscle neoplasm of uncertain biological potential. It is associated with Epstein-Barr virus infection and seen in patients with immunodeficiency, including primary immunodeficiency, HIV/AIDS infection, and post-transplant immunosuppression.


Locally Advanced Carcinoma

description: A carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Myocardial degeneration

description: Degeneration of myocardial tissue.


Astler-Coller C2 Colon Carcinoma

description: Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


name: Postneoadjuvant Therapy Stage IVB Esophageal Adenocarcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Gastrinoma, malignant

description: A gastrin-producing neuroendocrine tumor.  It is characterized by inappropriate secretion of gastrin and associated with Zollinger Ellison syndrome.  It displays vascular invasion and metastasizes to other anatomic sites.


name: Congenital Defects of Phagocyte Number, Function, or Both

description: A group of diseases or disorders caused by genetic defects within the immune system and comprising: Congenital neutropenia; Defects of motility; Defects of respiratory burst; and other nonlymphoid defects.


Megakaryocytic Neoplasm

description: A neoplasm affecting cells of the megakaryocytic lineage.


name: Chronic Cutaneous Graft Versus Host Disease

description: Chronic graft versus host disease (GvHD) occurring in the skin.


EBV positive mucocutaneous ulcer

description: A rare Epstein-Barr virus-positive B-cell lymphoproliferative disorder that affects mucosal sites (including oral mucosa, palate, tonsils, and gastrointestinal tract) and skin. It presents with well-circumscribed, often painful ulcers. It is associated with immune suppression, including age-related and drug-induced immunosuppression. In the majority of cases the lesions regress either spontaneously or following withdrawal of the immunosuppression therapy.


Malignant melanoma in junctional nevus

description: A melanoma arising from a melanocytic nevus which involves the dermal-epidermal junction of the skin.


name: Childhood Malignant Bone Neoplasm by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood malignant bone neoplasm according to the Toronto childhood cancer staging guidelines v2. Staging is the same for both tiers (tier 1 and 2).


description: A rare mucinous cystadenocarcinoma that arises from the paratesticular structures.


Recurrent Cancer of Gallbladder

description: The reemergence of gallbladder carcinoma after a period of remission.


Orbivirus infection

description: An infection that is caused by Orbivirus.


Unclassified Hepatocellular Adenoma

description: A hepatocellular adenoma without distinguished morphologic characteristics or known molecular abnormalities.


name: Congenital arteriovenous malformation of gastrointestinal tract

description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the gastrointestinal tract.


Contact dermatitis caused by acid

description: Contact dermatitis caused by exposure to acids.


Congenital His bundle tachycardia

description: A congenital disorder characterized by an electrocardiographic finding of tachycardia that affects neonates and infants. It results from an increased automaticity in the atrioventricular node and His bundle.


Extracranial Solid Neoplasm

description: A solid neoplasm involving any anatomic site other than the brain.


Childhood Ganglioneuroma

description: A ganglioneuroma that occurs during childhood.


Adenocarcinoma endometrial recurrent

description: The reemergence of endometrioid adenocarcinoma after a period of remission.


name: Myelodysplastic/Myeloproliferative Neoplasm Post Cytotoxic Therapy

description: A myelodysplastic/myeloproliferative neoplasm arising as a result of the mutagenic effect of chemotherapy agents and/or radiation that are used for the treatment of neoplastic or non-neoplastic disorders.


name: Adult Favorable Prognosis Hodgkin Lymphoma

description: A Hodgkin lymphoma with favorable prognosis that occurs during adulthood.


Unresectable Mucosal Melanoma

description: Mucosal melanoma that is not amenable to surgical resection.


Childhood Malignant Bone Neoplasm

description: A malignant neoplasm that affects the bone or articular cartilage and occurs during childhood.


name: Metastatic malignant neoplasm to soft tissues

description: A malignant neoplasm that has spread to the soft tissues from another anatomic site.


A2/3 Hydronephrosis

description: Antenatal hydronephrosis with the following clinical findings: 1) an anterior-posterior renal pelvis diameter (APRPD) of greater than or equal to 7mm at less than 28 weeks, 2) greater than or equal to10 mm at greater than or equal to 28 weeks, or 3) any one of the following findings: a)dilation of peripheral calyces, b) abnormal parenchymal thickness or appearance, c) visibly dilated ureter, d) an abnormal bladder, or e) the presence of oligohydramnios suspected to be related to the urinary tract. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


Carcinoma Unspecified Site

description: Carcinoma in which the site of involvement is not specified.


Locally Advanced Gallbladder Carcinoma

description: Gallbladder carcinoma that has spread to nearby tissues or lymph nodes.


Stage I Adult Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Stage II Esophageal Cancer AJCC v7

description: Stage II includes: For squamous cell carcinoma: IIA (T2-3, N0, M0, G1, GX, Tumor location: Upper, middle); (T2-3, N0, M0, G2-3, Tumor location: Lower, X); IIB (T2-3, N0, M0, G2-3, Tumor location: Upper, middle); (T1-2, N1, M0, Any G, Tumor location: Any).  For adenocarcinoma: IIA (T2, N0, M0, G3); IIB (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Acute Myeloid Leukemia with STAT5B-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of STAT5B-RARA fusion protein.


Posterior Subcapsular Cataract Grade 2

description: A stage of posterior subcapsular cataract characterized by 30% of the posterior capsule obscured by opacity. (Modified LOCS II)


Recurrent T-Cell and NK-Cell Neoplasm

description: The reemergence of T-cell and NK-cell neoplasm after a period of remission.


Cannabis dependence, continuous

description: Physical and psychological dependence on the drug cannabis, which is associated with a pattern of continuous use.


Skin tumor of neural origin

description: A peripheral nervous system neoplasm that arises from the dermis.


Locally Advanced Gastric Adenocarcinoma

description: A gastric adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Anal Canal Neuroendocrine Tumor G1

description: A well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the anal canal. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Renal Allograft Thrombosis

description: Thrombus formation within the arterial or venous system of a donor kidney post transplantation.


name: Bile Duct Biliary Intraepithelial Neoplasia

description: A neoplastic, non-invasive lesion that affects the intrahepatic or extrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


Locally Advanced Sarcoma

description: Sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Childhood EBV-Associated Smooth Muscle Tumor

description: An EBV-associated smooth muscle tumor that occurs during childhood.


Childhood Pilomatricoma

description: A pilomatricoma that occurs during childhood.


name: Locally Advanced Unresectable Bone Sarcoma

description: A bone sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Borderline Fallopian Tube Neoplasm

description: A rare epithelial tumor arising from the fallopian tube without definitive morphologic characteristics of malignancy.  This category includes borderline mucinous and serous neoplasms and borderline endometrioid tumor.


name: Recurrent Endometrial Serous Adenocarcinoma

description: The reemergence of endometrial serous adenocarcinoma after a period of remission.


name: Platinum-Refractory Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that progresses during platinum therapy or within one month of completing platinum therapy.


Stage IV Skin Cancer

description: Stage IV includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T Any, N3, M0); (T4, N Any, M0); (T Any, N Any, M1).  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  T3: Tumor with invasion of maxilla, mandible, orbit, or temporal bone.  T4: Tumor with invasion of skeleton or perineural invasion of skull base.  N0: No regional lymph node metastasis.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M1: Distant metastases.  (AJCC 7th Ed.)


Sebaceoma

description: A benign neoplasm characterized by sebaceous cell differentiation. It arises from the dermis and typically affects the face and neck.


Breast Papillary Neoplasm

description: A benign or malignant papillary neoplasm that arises from the breast.  It is characterized by the presence of epithelial proliferations that are supported by fibrovascular cores.  Representative examples are intraductal papilloma and papillary carcinoma.


name: Castleman Disease, Hyaline-Vascular Type

description: The commonest type of Castleman disease. It is seen most commonly in the mediastinum. Histologically this is characterized by hyalinized germinal centers surrounded by small lymphocytes in a concentric fashion, giving an onion skin appearance.


name: Invasive Bladder Giant Cell Urothelial Carcinoma

description: An invasive urothelial carcinoma of the bladder with giant cells.


Childhood Classic Hodgkin Lymphoma

description: Classic Hodgkin lymphoma that occurs during childhood.


name: Unresectable Digestive System Neuroendocrine Neoplasm

description: A digestive system neuroendocrine neoplasm that is not amenable to surgical resection.


Enteroglucagonoma

description: An endocrine neoplasm producing glucagon.


Hidroacanthoma Simplex

description: A poroma characterized by the presence of aggregates of basaloid cells confined to the epidermis.


Recurrent Nevus

description: A nevus that recurs after incomplete surgical removal, biopsy, or trauma. (WHO 2018)


name: Locally Advanced Squamous Cell Carcinoma

description: A squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Major Congenital Anomaly

description: A major congenital anomaly is a structural or functional defect with the following three characteristics: 1) Of prenatal origin; 2) Present at the time of live birth or fetal demise, or in utero; 3) Affecting (or has the propensity to affect) the health, survival, or physical or cognitive functioning of the individual.


Carcinoma of unknown primary

description: A carcinoma which has metastasized from an unknown primary anatomic site.


name: Hematopoietic and Lymphoid Neoplasm (Antiquated)


name: Invasive Lymphoepithelioma-Like Urothelial Carcinoma

description: Invasive urothelial carcinoma with lymphoepithelioma-like features.


Clinical Chorioamnionitis

description: Inflammation of the fetal sac membranes, characterized by otherwise unexplained fever (at or above 38 degree C (100.4F)) with one or more of the following: uterine tenderness and/or irritability, leukocytosis, fetal tachycardia, maternal tachycardia, or malodorous vaginal discharge.


name: Ventral hernia without mention of obstruction or gangrene

description: The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the linea alba, without mention of obstruction or necrosis of the herniated contents.


Lumbar meningomyelocele

description: A congenital abnormality in the lumbar region of the spine, in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Autoimmune Atrophic Chronic Gastritis

description: Chronic atrophic gastritis that is caused by autoimmune destruction of parietal cells in the stomach resulting in hypochlorhydria and decreased production of intrinsic factor.


Stage I Low-CSD Melanoma AJCC v7

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Locally Advanced Bladder Adenocarcinoma

description: Bladder adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Malignant Bladder Paraganglioma

description: An extra-adrenal sympathetic paraganglioma of the bladder that metastasizes to other anatomic sites.


Infant Leukemia

description: An acute lymphoblastic or acute myeloid leukemia that occurs in infancy.


name: Ancylostomiasis due to Ancylostoma ceylonicum (disorder)

description: Infection by Ancylostoma ceylanicum.


Distal Esophagus Adenocarcinoma

description: An adenocarcinoma arising from the lower third of the esophagus. The vast majority of esophageal adenocarcinomas involve the lower third of the esophagus.


name: Cervical intraepithelial neoplasia grade 1

description: Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of mild dysplastic changes.


Diffuse KATP-Associated Hyperinsulinism

description: KATP-associated hyperinsulinism affecting all pancreatic beta cells.


Recurrent Acute Erythroid Leukemia

description: The reemergence of acute erythroid leukemia after a period of remission.


name: Anxiety disorder due to a general medical condition

description: An anxiety disorder in which the symptoms of anxiety have been determined to be the direct physiological consequence of a general medical condition.


Stage IVB Cervical Cancer FIGO 2009

description: Cervical carcinoma involving distal organs outside the pelvis. (FIGO 2009)


Basal cell carcinoma - keratotic

description: A variant of basal cell carcinoma with the architectural features of a nodular basal cell carcinoma.  It is characterized by the formation of keratin (horn cysts) in the center of the tumor islands.  Dystrophic calcification is frequently present.


Allograft Thrombosis

description: Thrombus formation within the arterial or venous system of donor tissue post transplantation.


Anaplastic Diencephalic Astrocytoma

description: An anaplastic astrocytoma that occurs in the diencephalon.


Sclerosing Blue Nevus

description: A dendritic blue nevus characterized by the presence of prominent sclerotic stromal collagen.


description: A reactive proliferation of the conjunctival squamous epithelium not associated with glandular elements.


name: Philadelphia Chromosome Negative BCR-ABL1 Negative Chronic Myelogenous Leukemia


Recurrent Lymphoid Leukemia

description: The reemergence of lymphoid leukemia after a period of remission.


name: Lymphoproliferative Disease Associated with Primary Immune Disorder

description: A lymphoid proliferation that arises in the setting of immune deficiency due to a primary immunodeficiency or immunoregulatory disorder. The primary immune disorders most frequently associated with lymphoproliferative disorders are ataxia-telangiectasia, Wiskott-Aldrich syndrome, common variable immunodeficiency, severe combined immunodeficiency, X-linked lymphoproliferative disease, Nijmegen breakage syndrome, hyper-IgM syndrome, and autoimmune lymphoproliferative syndrome. (WHO 2017)


name: Recurrent Histiocytic and Dendritic Cell Neoplasm

description: The reemergence of a histiocytic and dendritic cell neoplasm after a period of remission.


Stage III Childhood Hodgkin Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Vascular anomaly of eyelid

description: Any non-neoplastic or neoplastic disorder affecting the arteries, veins, or lymphatic vessels of the eyelid.


name: Stage III Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, Any N, M0). T1: Pheochromocytoma measuring less than 5 cm in greatest dimension, with no extra-adrenal invasion. T2: Pheochromocytoma measuring 5 cm or more in greatest dimension or paraganglioma-sympathetic of any size, with no extra-adrenal invasion. T3: Tumor of any size with invasion into surrounding tissues (e.g., liver, pancreas, spleen, kidneys). N1: Regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Stage IIIA Esophageal Adenocarcinoma AJCC v7

description: Stage IIIA includes: (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


verrucous carcinoma of vagina

description: A squamous cell carcinoma that arises from the vagina and is characterized by a papillary growth pattern, acanthotic epithelium with minimal or absent atypia, and pushing borders.


name: Testicular Seminoma with Syncytiotrophoblastic Cells

description: A testicular seminoma characterized by the presence of syncytiotrophoblastic giant cells.


Peritoneal Implant

description: Deposits of borderline, malignant, and rarely benign tumors, usually from the ovary, on the peritoneal surface.


Resectable Cutaneous Melanoma

description: Cutaneous melanoma that is amenable to surgical resection.


name: Adult Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

description: An acute myeloid leukemia with recurrent genetic abnormalities occurring in adults.


High Grade Liver Dysplastic Nodule

description: A hepatic dysplastic nodule characterized by the presence of high grade atypical cellular changes.


Sporadic Gastric Adenocarcinoma

description: A primary adenocarcinoma of the stomach in a patient with no family history of gastric cancer or inherited high risk mutations.


Subacute Placental Infarction

description: A focus of necrotic placental parenchyma with moderate hyalinization and fibrosis with partial absence of the necrotic chorionic villi, which is frequently 3-5 days of duration.


K ATP Permanent Neonatal Diabetes

description: K ATP channel-associated neonatal diabetes mellitus that does not resolve spontaneously.


Resectable Sarcoma

description: Sarcoma that is amenable to surgical resection.


description: Thrombotic microangiopathy of the gastrointestinal tract.


name: Clinical Stage I Cutaneous Melanoma AJCC v8

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Advanced Adnexal Carcinoma

description: Adnexal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Endometrial cystic hyperplasia

description: Benign endometrial hyperplasia characterized by the presence of cystically dilated glands.


Childhood Skin Neoplasm

description: A benign, intermediate, or malignant neoplasm that affects the skin and occurs during childhood.


name: Malignant Lymphoma, Histiocytic, Diffuse


Papillary mucinous cystadenoma

description: A usually benign and less often low malignant potential cystic epithelial neoplasm composed of cells which contain intracytoplasmic mucin. It is characterized by the presence of papillary structures.


name: Acute gonococcal infection of lower genitourinary tract

description: A gonococcal infection of the lower urinary tract that is rapid in onset.


Parathyroid Clear Cell Hyperplasia

description: A hyperplasia of the clear cells of the parathyroid gland.


name: FIGO Stage II Gestational Trophoblastic Tumor

description: Lesion invades outside of the uterus, but it is limited to the genital structures.


Malignant Paraganglionic Neoplasm

description: A paraganglioma that metastasizes to regional or distant anatomic sites.  Extraadrenal paragangliomas have a higher tendency to metastasize, as compared to pheochromocytomas.  Common sites of metastasis include the lymph nodes, lungs, bones, and liver.


name: Psychotic disorder due to a general medical condition

description: A psychotic disorder characterized by prominent hallucinations or delusions that have been determined to be etiologically linked to a general medical condition.


Stage II Prostate Cancer AJCC v7

description: Stage II includes: IIA (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X); IIB (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  T2c: Tumor involves both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


Stage IV Cervical Cancer FIGO 2018

description: The cervical carcinoma has extended beyond the true pelvis or has involved (biopsy proven) the mucosa of the bladder or rectum. (A bullous edema, as such, does not permit a case to be allotted to Stage IV). (FIGO 2018)