name: Splenic Manifestation of Chronic Lymphocytic Leukemia

description: Infiltration of the spleen by chronic lymphocytic leukemia. It primarily involves the white pulp.


CYSTODYTIN G

An alkaloid that is an enamide obtained by the formal condensation of tiglic acid with 6-(2-amino-1-methoxyethyl)-4H-pyrido[2,3,4-kl]acridin-4-one. It is isolated from the Okinawan marine tunicate Cystodytes dellechiajei and exhibits cytotoxicity against human epidermoid carcinoma KB cells


A 6-lactoyl-5,6,7,8-tetrahydropterin in which the stereocentre at position 6 has R-configuration.


GMP catabolic process to IMP

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including inosine monophosphate.


Kaposi's sarcoma of oral cavity

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Kaposi sarcoma arising from the oral cavity.


dextromoramide

An N-acylpyrrolidine arising by formal condensation of pyrrolidine with (3S)-3-methyl-4-(morpholin-4-yl)-2,2-diphenylbutanoic acid. An opioid analgesic that is structurally related to methadone, it is more poweful than morphine but shorter acting. It has been used (particularly as the hydrogen tartrate salt) for the treatment of severe pain, but was discontinued in the UK in 2004.


deisopropylatrazine

A diamino-1,3,5-triazine that is N-ethyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.


Parotid Gland Lipoma

description: A lipoma that arises from the parotid gland.


A lysophosphatidylethanolamine zwitterion in which the remaining acyl group (position not specified) contains 20 carbons and 0 double bonds.


name: adenylate cyclase-inhibiting adrenergic receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor, and ending with the regulation of a downstream cellular process.


An amino trisaccharide consisting of 2-acetamido-2-deoxy-alpha-D-galactopyranose, beta-D-galactopyranose and alpha-D-glucopyranose residues joined in sequence by (1->3) and (1->4) glycosidic bonds.


name: chanoclavine-I aldehyde biosynthetic process

description: The chemical reactions and pathways resulting in the formation of chanoclavine-I aldehyde. Chanoclavine-I aldehyde is at a branching point in the biosynthetic pathways of fumigaclavine C and ergotamine.


name: positive regulation of ERBB signaling pathway

description: Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway.


name: positive regulation of epidermal growth factor receptor signaling pathway involved in heart process

description: Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process.


name: positive regulation of ERBB3 signaling pathway

description: Any process that activates or increases the frequency, rate or extent of ERBB3 signaling pathway.


poacic acid

A hydroxycinnamic acid that is (2E)-3-phenylprop-2-enoic acid in which the hydrogens at positions 3, 4 and 5 are replaced by 2-(4-hydroxy-3-methoxyphenyl)ethenyl, hydroxy and methoxy groups, respectively. It is a natural product found in maize bran which exhibits antifungal activities against several fungal and oomycete pathogens including Sclerotinia sclerotiorum, Alternaria solani, and Phytophthora sojae. It inhibits beta-1,3-glucan synthesis in cells walls resulting in rapid cell lysis.


methyl sulfate

An alkyl sulfate that is the monomethyl ester of sulfuric acid.


name: symbiont-mediated suppression of host complement activation by complement sequestering

description: A process by which a symbiont prevents host complement activation by sequestering it away from its surface.


name: symbiont-mediated suppression of host complement activation

description: A process by which a symbiont inhibits or disrupts the normal execution of the activation of complement in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: symbiont-mediated suppression of host complement activation by activation of host proteases

description: A process by which a symbiont prevents host complement activation by recruiting host proteases, destroying the complement before it has its effect on the symbiont.


name: symbiont-mediated suppression of host complement activation by recruitment of complement control protein

description: A process by which a symbiont prevents the activation of host complement by binding a soluble complement control protein (CCP) of the host and recruiting it to the microbe surface. The normal role of CCPs is to prevent complement activation on 'self' cellular targets. When soluble CCPs are recuited to the surface of a microbe, the complement fails to activate.


name: symbiont-mediated suppression of host complement activation by inactivation of complement proteins

description: A process by which a symbiont disrupts or prematurely activates host complement so that its microbial-destroying activities fail.


diazine

The parent structure of the diazines.


PYRIMIDINE

The parent compound of the pyrimidines; a diazine having the two nitrogens at the 1- and 3-positions.


PYRAZINE

A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.


4-hydroxy-3-methylbenzoic acid

A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methyl group at position 3.


An  oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.


name: benzoic acid [3,4-dibenzoyloxy-5-(2,4-dioxo-5-propan-2-yl-1-pyrimidinyl)-2-oxolanyl]methyl ester


APRATOXIN D

An aprotoxin having the common aprotoxin cyclodepsipeptide skeleton where the isoleucyl residue carries an N-methyl substituent and the side-chain adjacent to the lactone is (2R)-4,4-dimethylpentan-2-yl. It is isolateed from Lyngbya majuscula and Lyngbya sordida and exhibits anticancer properties.


A 2,3-diacyl-1-alpha-D-galactosyl-sn-glycerol in which the groups at the 2- and 3-positions are oleoyl and palmitoyl respectively.


enediyne

Any organic entity containing a conjugated system of two carbon-carbon triple bonds separated by a carbon-carbon double bond (i.e. a 3-ene-1,5-diyne system).


name: regulation of dehydroaustinol biosynthetic process

description: Any process that modulates the frequency, rate or extent of dehydroaustinol biosynthetic process.


name: negative regulation of dehydroaustinol biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of dehydroaustinol biosynthetic process.


category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2.


ethyl phenylcyanoacetate

An alpha-substituted cyanoacetate ester that consists of ethyl cyanoacetate bearing an alpha-phenyl substituent.


A 1-alkyl-2-acyl-sn-glycero-3-phosphate in which the alkyl and acyl groups are specified as palmityl (hexadecyl) and oleoyl respectively.


A branched amino pentasaccharide comprising a linear tetrasaccharide chain of alpha-N-acetylneuramine, beta-D-galactose, N-acetyl-beta-D-glucosamine and alpha-D-mannose residues linked sequentially (2->3), (1->4) and (1->2), to the N-acetyl-beta-D-glucosamine residue of which is also linked (1->3) an alpha-L-fucose residue.


A glycerophosphoethanolamine that is sn-glycero-3-phosphoethanolamine in which positions 1 and 2 are substituted by unspecified acyl and alkyl groups, and in which the positions of the acyl and alkyl groups are also unspecified.


phosphatidylethanolamine O-37:1

An alkyl,acyl-sn-glycero-3-phosphoethanolamine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 37 carbons and 1 double bond.


An alkyl,acyl-sn-glycero-3-phosphoethanolamine in which unspecified alkyl and acyl groups are located at positions 1 and 2 respectively.


A 1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine in which the alkyl and the acyl groups at positions 1 and 2 are specified as eicosyl and linolenyl respectively.


phosphatidylethanolamine O-39:5

An alkyl,acyl-sn-glycero-3-phosphoethanolamine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 39 carbons and 5 double bonds.


An alkyl,acyl-sn-glycero-3-phosphoethanolamine in which unspecified acyl and alkyl groups are located at positions 1 and 2 respectively.


A 2-acyl-1-alkyl-sn-glycero-3-phosphoethanolamine in which the alkyl and the acyl groups at positions 1 and 2 are specified as hexadecyl and acetyl respectively.


azulenes

Any carbobicyclic compound whose skeleton consists of a cyclopentane ring ortho-fused to a cycloheptane ring.


A member of the class of azulenes that is azulene substituted by methyl groups at positions 4, 6 and 8 respectively.


azulene

A mancude carbobicyclic parent consisting of a cycloheptatriene and cyclopentadiene rings.


glucarate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid.


glucarate metabolic process

description: The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate.


glucarate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid.


D-glucarate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of D-glucarate, the D-enantiomer of glucarate.


D-glucarate metabolic process

description: The chemical reactions and pathways involving D-glucarate, the D-enantiomer of glucarate. D-glucarate is derived from either D-glucose or L-gulose.


D-glucarate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of D-glucarate, the D-enantiomer of glucarate.


HYDRANGENOL

A member of the class of dihydroisocoumarins that is 3,4-dihydroisocoumarin substituted by a hydroxy group at position 8 and a 4-hydroxyphenyl group at position 3. It has been isolated from the roots of Scorzonera judaica and exhibits anti-allergic activity.


beta-D-quinovofuranose

A D-quinovose (6-deoxy-D-glucose) that is D-quinovofuranose in which the anomeric centre has beta configuration.


tin dioxide

A tin oxide compound consisting of tin(IV) covalently bound to two oxygen atoms.


tin oxide

A metal oxide containing tin and oxygen.


bexagliflozin

A C-glycosyl comprising of beta-D-glucose in which the anomeric hydroxy group is replaced by a 4-chloro-3-({4-[2-(cyclopropyloxy)ethoxy]phenyl}methyl)phenyl group. It is a sodium-glucose co-transporter 2 (SGLT2) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.


name: regulation of transcription-coupled nucleotide-excision repair

description: Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.


name: regulation of nucleotide-excision repair

description: Any process that modulates the frequency, rate or extent of nucleotide-excision repair.


A zwitterionic group obtained by transfer of a proton from the phosphate to the amino group of 3'-(L-pyrrolysyl)adenylyl group


name: cholesterol biosynthetic process via 24,25-dihydrolanosterol

description: The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate 24,25-dihydrolanosterol.


An amino tetrasaccharide in which an N-acetylglucosamine residue is linked beta(1->6) to the residue at the reducing end of a linear chain of two galactose residues and an N-acetylglucosamine residue.


name: modulation by symbiont of host protein localization to phagocytic vesicle

description: Any process in which an organism modulates the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction.


manganese(II) sulfate hexahydrate

A hydrate that is the hexahydrate form of manganese(II) sulfate.


name: Ann Arbor Stage I Lymphocyte-Depleted Classic Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


name: Ann Arbor Stage I Supradiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


name: Ann Arbor Stage I Subdiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


A triacyl-sn-glycerol in which the 1-acyl group is octadecanoyl while the 2- and 3-acyl groups are oleoyl.


Diaper Rash

description: An inflammatory skin condition in the diaper area that may be caused by irritation or infection.


Diaper candidiasis

description: An inflammatory skin condition in the diaper area superimposed with Candida infection, characterized by a bright red rash with a sharply demarcated edge and satellite lesions. Skin folds are often involved.


The (6aS,11aS)-enantiomer of pterocarpan.


cellular hypotonic salinity response

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.


GLYCEOLLIN III

A benzofuropyranochromene that is 1,2-dihydro-6H-[1]benzofuro[3,2-c]furo[3,2-g]chromene substituted at positions 6a and 9 by hydroxy groups and at position 2 by a prop-1-en-2-yl group.


GLYCEOLLIN II

A benzofuropyranochromene that is 3H,7H-[1]benzofuro[3,2-c]pyrano[3,2-g]chromene substituted at positions 7a and 10 by hydroxy groups and at position 3 by a gem-dimethyl group.


A nucleoside residue in which an adenosine residue has been modified by substitution at C-2 by a mercapto (sulfanyl) group and at the 6-amino nitrogen by a Delta(2)-isopentenyl group.


A trisaccharide derivative consisting of an alpha-D-glucosyl residue glycosidically linked to a 5-aminopentyl group and which carries at O-4 an alpha-L-rhamnosyl-(1->3)-beta-D-glucosyl disaccharide unit.


name: Stage IB Adult Soft Tissue Sarcoma AJCC v7


name: 4-(2-phenylethylsulfamoyl)-1H-pyrrole-2-carboxylic acid methyl ester


A trideoxyhexose comprising D-galactopyranose having the hydroxy groups at positions 2- and 4- replaced by acetamido and amino groups respectively and also deoxygenated at the 6-position.


regulation of type IIa hypersensitivity

description: Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response.


name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

description: Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.


name: negative regulation of type IIa hypersensitivity

description: Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response.


name: negative regulation of tolerance induction to nonself antigen

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen.


name: positive regulation of T-helper 17 cell differentiation

description: Any process that activates or increases the frequency, rate or extent of T-helper 17 cell differentiation.


name: positive regulation of T cell mediated cytotoxicity

description: Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.


name: negative regulation of T-helper 1 cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation.


name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.


regulation of type III hypersensitivity

description: Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response.


name: positive regulation of humoral immune response mediated by circulating immunoglobulin

description: Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.


name: positive regulation of B cell mediated immunity

description: Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity.


name: positive regulation of germinal center formation

description: Any process that activates or increases the frequency, rate, or extent of germinal center formation.


name: regulation of T cell antigen processing and presentation

description: Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation.


name: negative regulation of tolerance induction dependent upon immune response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response.


regulation of type IV hypersensitivity

description: Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response.


name: positive regulation of T cell antigen processing and presentation

description: Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation.


name: regulation of T-helper 17 cell differentiation

description: Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation.


name: positive regulation of complement activation, classical pathway

description: Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway.


name: regulation of antibody-dependent cellular cytotoxicity

description: Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity.


name: positive regulation of type II hypersensitivity

description: Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity.


name: negative regulation of B cell antigen processing and presentation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation.


name: regulation of immunoglobulin mediated immune response

description: Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response.


name: negative regulation of humoral immune response mediated by circulating immunoglobulin

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.


regulation of T cell mediated immunity

description: Any process that modulates the frequency, rate, or extent of T cell mediated immunity.


name: positive regulation of type IIa hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response.


name: negative regulation of complement activation, classical pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway.


name: regulation of tolerance induction to nonself antigen

description: Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen.


name: positive regulation of T-helper 1 cell differentiation

description: Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation.


regulation of germinal center formation

description: Any process that modulates the frequency, rate, or extent of germinal center formation.


name: positive regulation of T cell mediated immunity

description: Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity.


name: positive regulation of B cell antigen processing and presentation

description: Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation.


name: negative regulation of type IIb hypersensitivity

description: Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response.


name: positive regulation of immunoglobulin mediated immune response

description: Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.


name: positive regulation of T-helper 17 type immune response

description: Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response.


name: regulation of tolerance induction dependent upon immune response

description: Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response.


name: negative regulation of T-helper 17 cell lineage commitment

description: Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell lineage commitment.


name: helper T cell enhancement of B cell mediated immune response

description: Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell.


name: positive regulation of type IIb hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response.


name: regulation of B cell antigen processing and presentation

description: Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation.


name: negative regulation of type II hypersensitivity

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity.


regulation of type I hypersensitivity

description: Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response.


name: negative regulation of immunoglobulin mediated immune response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response.


name: regulation of humoral immune response mediated by circulating immunoglobulin

description: Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.


name: negative regulation of T cell antigen processing and presentation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation.


name: regulation of T-helper 17 cell lineage commitment

description: Any process that modulates the frequency, rate or extent of T-helper 17 cell lineage commitment.


name: positive regulation of peripheral tolerance induction

description: Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction.


name: negative regulation of T-helper 17 cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation.


name: negative regulation of T cell mediated immunity

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.


name: positive regulation of tolerance induction to nonself antigen

description: Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen.


name: helper T cell enhancement of T cell mediated immune response

description: Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell.


name: regulation of complement activation, classical pathway

description: Any process that modulates the frequency, rate or extent of the classical pathway of complement activation.


name: regulation of T-helper 1 type immune response

description: Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response.


name: negative regulation of antibody-dependent cellular cytotoxicity

description: Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity.


name: positive regulation of T-helper 1 type immune response

description: Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.


name: negative regulation of B cell mediated immunity

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity.


name: regulation of peripheral tolerance induction

description: Any process that modulates the frequency, rate, or extent of peripheral tolerance induction.


regulation of type II hypersensitivity

description: Any process that modulates the frequency, rate, or extent of type II hypersensitivity.


name: positive regulation of tolerance induction dependent upon immune response

description: Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response.


name: negative regulation of T cell mediated cytotoxicity

description: Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.


name: susceptibility to T cell mediated cytotoxicity

description: The process of causing a cell to become susceptible to T cell mediated cytotoxicity.


name: regulation of T cell mediated cytotoxicity

description: Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity.


name: regulation of T-helper 1 cell differentiation

description: Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation.


name: negative regulation of type III hypersensitivity

description: Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response.


name: negative regulation of type I hypersensitivity

description: Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response.


regulation of type IIb hypersensitivity

description: Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response.


name: positive regulation of type IV hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response.


name: positive regulation of type III hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response.


name: helper T cell enhancement of adaptive immune response

description: Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell.


name: negative regulation of peripheral tolerance induction

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction.


name: negative regulation of germinal center formation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation.


name: positive regulation of type I hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response.


regulation of B cell mediated immunity

description: Any process that modulates the frequency, rate, or extent of B cell mediated immunity.


name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

description: Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.


name: regulation of T-helper 17 type immune response

description: Any process that modulates the frequency, rate or extent of T-helper 17 type immune response.


name: negative regulation of type IV hypersensitivity

description: Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response.


name: negative regulation of T-helper 1 type immune response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response.


name: negative regulation of T-helper 17 type immune response

description: Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 type immune response.


aceclofenac

A monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.


compound E

An L-alanine derivative that is the amide obtained by formal condensation of the carboxy group of N-[(3,5-difluorophenyl)acetyl]-L-alanine with the amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one. An inhibitor of memapsin 2 (gamma-secretase).


1-hexyl-3-methylimidazolium chloride

An organic chloride salt in which the cationic component is 1-hexyl-3-methylimidazolium.


Congenital anomaly of tricuspid valve

description: A defect of the tricuspid valve present at birth.


(KDO)2-(palmitoleoyl)-lipid IVA

A lipid A comprising lipid IVA glycosylated with two 3-deoxy-D-manno-octulosonic acid (KDO) residues and carrying an additional palmitoleoyl group.


ASPIDOSPERMINE

An indole alkaloid having the structure of aspirospermidine methoxylated at C-17 and acetylated at N-1.


epinephrine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.


Midgut Neuroendocrine Tumor G1

description: A neuroendocrine tumor grade 1 that arises from the jejunum, ileum, proximal colon, or appendix.


name: Metastatic Midgut Neuroendocrine Tumor G1

description: A midgut neuroendocrine tumor G1 that has spread from its original site of growth to another anatomic site.


A methyl-branched fatty acyl-CoA obtained from the formal condensation of the thiol group of coenzyme A with the carboxy group of (E)-isoheptadec-2-enoic acid.


An ammonium ion resulting from the protonation of the nitrogen of (R)-benproperine.


name: Locally Advanced Digestive System Neuroendocrine Tumor G3

description: Digestive system neuroendocrine tumor G3 that has spread from its original site of growth to nearby tissues or lymph nodes.


A secondary amino compound that is spermidine in which each of the primary amino groups has been mono-acylated by formal condensation with trans-sinapic acid.


name: Psoralen and long-wave ultraviolet radiation (PUVA) keratosis

description: A hyperkeratotic skin lesion that occurs in patients with a history of prolonged exposure to psoralen and ultraviolet A (PUVA) therapy.


6-hydroxyferulic acid derivative

6-hydroxyferulic acid derivative


polonium-210 atom

The radioactive isotope of polonium with relative atomic mass 209.98286 and half-life of 138.376 days; the only naturally occurring isotope of polonium.


A branched trisaccharide that is alpha-L-Fucp-(1->3)-alpha-D-Galp in which the hydroxy group at position 4 of the D-galactopyranose moiety has been glycosylated by an alpha-D-glucopyranosyl group.


A medium-chain primary fatty alcohol that is dodecane carrying hydroxy groups at positions 1 and 11.


Ro 48-8071 fumarate

A fumarate salt obtained by combining Ro 48-8071 with one molar equivalent of fumaric acid. An inhibitor of lanosterol synthase.


tungsten disulfide nanotube

A nanotube consisting of tungsten disulfide.


L-mannitol

The L-enantiomer of mannitol.


name: modulation of relaxation of smooth muscle in another organism

description: The process in which an organism effects a change in the relaxation of smooth muscle in a second organism.


name: positive regulation of relaxation of uterine smooth muscle in another organism

description: The process in which an organism increases the extent of relaxation of smooth muscle in the uterus of a second organism.


name: modulation of relaxation of uterine smooth muscle in another organism

description: The process in which an organism effects a change in the relaxation of smooth muscle in the uterus of a second organism.


alpha-(methylamino)isobutyric acid

A non-proteinogenic alpha-amino acid that is isobutyric acid in which the alpha-hydrogen has been replaced by a methylamino group.


A methyl-branched fatty acyl-CoA obtained from the formal condensation of the thiol group of coenzyme A with the carboxy group of 3-hydroxyisopentadecanoic acid.


Oral Cavity Mucosal Melanoma

description: A rare melanoma that arises from the oral cavity. It is associated with a poor prognosis.


translation at presynapse

description: Translation that occurs at the presynapse.


name: translation at presynapse, modulating chemical synaptic transmission

description: Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.


A member of the class of piperidines that is TEMPO carrying a methacryloyloxy group at position 4.


aplysiatoxins

A class of macrodiolides that consists of aplysiatoxin and its structural analogues.


A racemate comprising an equimolar mixture of the two stereoisomers of 4-dodecyl-2,5-dimethylmorpholine in which the methyl substituents are in a trans relationship to each other.


pseudorotaxane

A system consisting of a macrocycle non-covalently bound to a spindle molecule.


Pseudorotaxane consisting of a single macrocycle and a spindle molecule.


Pseudorotaxane consisting of three macrocycles and a spindle molecule.


Pseudorotaxane consisting of two macrocycles and a spindle molecule.


Conjugate base of bkos#14


tabtoxinine-delta-lactam

A delta-lactam that is L-pipecolic acid carrying additional hydroxy and aminomethyl substituents at position 5 as well as an oxo substituent at position 6.


Childhood Posterior Fossa Ependymoma

description: A posterior fossa ependymoma that occurs during childhood.


N-methylfentanyl

The monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of 1-methyl-N-phenylpiperidin-4-amine with propanoic acid.


LEUPROLIDE ACETATE

An acetate salt obtained by combining the nonapeptide leuprolide with acetic acid. A long lasting GnRH analog, LH-Rh agonist. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.


AMINOHIPPURATE SODIUM

An organic sodium salt that is the monosodium salt of p-aminohippuric acid.


double-walled carbon nanotube

A carbon nanotube consisting of two concentric graphene cylinders.


multi-walled carbon nanotube

A molecule consisting of three or more concentric graphene cylinders.


carbon nanorope

A carbon nanostructure consisting of carbon nanotubes which have been spun or bundled together.


zigzag carbon nanotube

A single walled carbon nanotube with (n,m) indices equal to (n,0) or (0,m). Zigzag carbon nanotubes have a chiral angle of 0degree and can be either metallic or semiconducting.


carbon nanofibre

A carbon nanostructure consisting of layers of stacked graphite cones or plates.


carbon nanohorn

A single-walled carbon nanostructure with an irregular horn-like shape.


armchair carbon nanotube

A single-walled carbon nanotube with equal n and m indices. Armchair carbon nanotubes have a chiral angle of 30degree and are metallic.


carbon black nanoparticle

Any form of carbon black which has a particle size of less than 100 nm in each dimension.


metallic single-walled carbon nanotube

A single-walled carbon nanotube with (n,m) indices such that n-m is a multiple of 3.


chiral carbon nanotube

A single-walled carbon nanotube with unequal (n,m) indices and a chiral angle of between 0 and 30degree.


single-walled carbon nanotube

A carbon nanotube consisting of a single graphene cylinder. Different kinds of single-walled carbon nanotube are distinguished by the indices (n,m) which describe the vector along which the graphene is rolled. The chiral angle is the angle between the vector and the origin and can take any value between 0 and 30degree.


name: semiconducting single-walled carbon nanotube

description: A single-walled carbon nanotube with (n,m) indices such that n-m is not a multiple of 3.


carbon nanotube

A molecule consisting of a graphene cylinder or two or more concentric graphene cylinders.


NAPROPAMIDE

A racemate composed of equimolar amounts of (S)- and (R)-napropamide.


vanilloyl-CoA

A member of the class of benzoyl-CoAs having 4-hydroxy-3-methoxybenzoyl (also known as vanilloyl) as the aroyl group. A potential intermediate of vanillate biosynthesis.


tramadol

A 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer.


cellular response to L-canavanine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus. L-canavanine is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group.


An organic cation that is the conjugate acid of memantine obtained by protonation of the primary amino function.


lanthionine ketimine

A member of the class of 1,4-thiazines that is 3,6-dihydro-2H-1,4-thiazine substituted by carboxy groups at positions 3 and 5. It is a natural but non-proteogenic amino acid found in human urine and brain.


name: positive regulation of dentin-containing tooth bud formation by mesenchymal-epithelial signaling

description: Any process that initiates the formation of a tooth bud by the secretion of a signal from a mesenchymal cell and its reception and subsequent change in the identity of an epithelial cell of the tooth bud.


name: positive regulation of cardiac muscle cell apoptotic process

description: Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.


Adult Benign Brain Stem Neoplasm

description: A benign neoplasm of the brain stem occurring in adults.


Medullary Hemangioblastoma

description: A hemangioblastoma that arises from the medulla oblongata.


Childhood Brain Stem Gliosarcoma

description: A gliosarcoma that arises from the brain stem and occurs during childhood.


Childhood Brain Stem Mixed Glioma

description: A mixed glioma that arises from the brain stem and occurs during childhood.


name: Metastatic malignant neoplasm to brain stem

description: A malignant neoplasm that has spread from its original site of growth to the brain stem.


Recurrent Childhood Brain Stem Glioma

description: The reemergence of brain stem glioma in childhood after a period of remission.


Anaplastic Brain Stem Astrocytoma

description: An anaplastic astrocytoma that arises from the brain stem.


Brain Stem Glioblastoma

description: A glioblastoma that arises from the brain stem.


Anaplastic Brain Stem Glioma

description: An anaplastic glioma that arises from the brain stem.


name: cellular response to phosphate starvation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.


The simplest member of the class of 2-hydroxy-1,4-benzoquinones, that is 1,4-benzoquinone in which a single hydrogen is replaced by a hydroxy group.


miltefosine

A phospholipid that is the hexadecyl monoester of phosphocholine.


Recurrent Acute Bilineal Leukemia

description: The reemergence of acute bilineal leukemia after a period of remission.


name: Recurrent Mixed Phenotype Acute Leukemia

description: The reemergence of mixed phenotype acute leukemia after a period of remission.


acute biphenotypic leukemia in relapse

description: The reemergence of acute biphenotypic leukemia after a period of remission.


description: The monomethylation of the N-terminal serine of proteins to form the derivative N-methylserine.


HOMOPHENYLALANINE

A non-proteinogenic L-alpha-amino acid that is an analogue of L-phenylalanine having a 2-phenylethyl rather than a benzyl side-chain.


phosphonoacetate metabolic process

description: The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a substance composed of an acetate and a phosphonic acid residue.


An N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine in which the acyl group has 21 carbons and 1 double bond.


cspyrone B1 biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cspyrone B1.


sodium gluconate

An organic sodium salt having D-gluconate as the counterion.


PHENTHOATE

An organic thiophosphate that is  ethyl mandelate in which the hydroxy group has been replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.


An amphipholic trifluorene having hexyl and N,N-bis(2-hydroxyethyl)aminophenyl side-chains.


oligofluorene

A compound containing a small number of fluorene units.


trifluorene

An oligofluorene containing three fluorene units.


A member of the class of coumarins  that consists of coumarin substituted by a senecioyloxymethyl group at position 4 and methoxy groups at positions 6 and 7. Isolated from Crinum latifolium, it exhibits anti-angiogenic activity.


name: Ampulla of Vater Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region. The Ki-67 index is higher than 20%.


name: Low Risk Small Intestinal Gastrointestinal Stromal Tumor


name: Low Risk Esophageal Gastrointestinal Stromal Tumor


name: Low Risk Colorectal Gastrointestinal Stromal Tumor


name: Low Risk Gastric Gastrointestinal Stromal Tumor


NOCICEPTIN

A seventenn-membered polypeptide consisting of Phe, Gly, Gly, Phe, Thr, Gly, Ala, Arg, Lys, Ser, Ala, Arg, Lys, Leu, Ala, Asn and Gln residue joined in sequence.


perfluoropentanoic acid

A monocarboxylic acid that is perfluorinated pentanoic acid.


An  indole alkaloid that is canthin-6-one substituted by a hydroxy group at position 9. Isolated from the roots of Eurycoma longifolia, it exhibits antineoplastic activity.


CRATOXYARBORENONE C

A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1 and 3, methoxy groups at positions 5 and 7 and two isoprenyl groups at positions 2 and 8 respectively. It is isolated from Cratoxylum Sumatranum and exhibits cytotoxicity towards the KB (human oral epidermoid) cancer cell line


A glucosylglycerol phosphate consisting of sn-glycerol 3-phosphate having a beta-D-glucosyl residue attached at position 2.


name: 4-amino-1,2,5-oxadiazole-3-carboxylic acid [2-(2,6-dimethylanilino)-2-oxoethyl] ester


A glycohexaosylceramide having beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycohexaosyl component.


Ser-Trp-Lys

A tripeptide formed from L-serine, L-tryptophan and L-lysine residues joined in sequence by peptide linkages.


A branched amino nonasaccharide derivative that is beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc in which the mannosyl group is substituted at position 3 by a beta-D-GlcNAc-(1->2)-alpha-D-Man group and at position 6 by an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man group, while the D-GlcNAc residue at the reducing end is substituted at position 6 by an alpha-L-Fuc residue.


A branched amino nonasaccharide derivative that is beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc in which the mannosyl group is substituted at position 3 by a beta-D-GlcNAc-(1->2)-alpha-D-Man group and at position 6 by an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man group, while the D-GlcNAc residue at the reducing end is substituted at position 6 by an alpha-L-Fuc residue.


description: Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.


hexadecanedioic acid

An alpha,omega-dicarboxylic acid that is the 1,14-dicarboxy derivative of tetradecane.


name: Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type

description: A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that form thin-branching papillae and exhibit high grade dysplasia.


name: Pancreatic Intraductal Papillary Mucinous Neoplasm, Gastric-Type

description: A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that are similar to gastric foveolar epithelial cells.


name: Branch Duct Pancreatic Intraductal Papillary-Mucinous Neoplasm

description: An intraductal papillary-mucinous neoplasm of the pancreas that arises in one of the branches of the main pancreatic duct.  It usually has an indolent behavior.


name: Mixed Type Pancreatic Intraductal Papillary-Mucinous Neoplasm

description: An intraductal papillary-mucinous neoplasm of the pancreas that arises primarily from the main pancreatic duct and extends to the branch ducts.


name: Pancreatic Intraductal Papillary Mucinous Neoplasm, Oncocytic-Type

description: A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells with abundant eosinophilic granular cytoplasm.


name: Main Duct Pancreatic Intraductal Papillary-Mucinous Neoplasm

description: An intraductal papillary-mucinous neoplasm of the pancreas that arises from the main pancreatic duct.


name: Pancreatic Intraductal Papillary Mucinous Neoplasm, Intestinal-Type

description: A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that form tall papillae, similar to those that are present in colonic villous adenomas.


name: positive regulation of vascular endothelial growth factor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor signaling pathway.


toluene oxidation via 4-hydroxytoluene

description: The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol).


toluene metabolic process

description: The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications.


toluene oxidation to catechol

description: The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2).


toluene oxidation

description: The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in toluene.


anaerobic toluene metabolic process

description: The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen.


toluene oxidation via 2-hydroxytoluene

description: The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol).


toluene oxidation via 3-hydroxytoluene

description: The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol).


name: toluene oxidation via toluene-cis-1,2-dihydrodiol

description: The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol.


toluene catabolic process

description: The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products.


anaerobic toluene catabolic process

description: The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen.


Advanced Rhabdoid Tumor

description: Rhabdoid tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Rhabdoid Tumor

description: A rhabdoid tumor that has spread from the original site of growth to another anatomic site.


beta-D-rhamnofuranose

A D-rhamnofuranose having beta-configuration at the anomeric centre.


name: sialadenoma papilliferum of salivary gland

description: An uncommon exophytic papillary proliferation that involves mucosal surface epithelium and salivary duct epithelium. It is exceptional among salivary gland neoplasms because it manifests as an exophytic papillary excrescence of the mucosa, rather than as a submucosal or intraglandular mass. It most often affects the hard or soft palate.  It is generally asymptomatic.


C-type aurachin

Any aurachin in which the farnesyl residue is positioned at C3 of the quinoline core (cf. A-type aurachin, in which the farnesyl residue is positioned at C4). C-type aurachins are converted into A-type aurachins by late stage tailoring reactions.


aurachin

Compounds comprising a class of isoprenoid quinoline alkaloids originally isolated from the myxobacterium Stigmatella aurantiaca together with their semi-synthetic and fully synthetic analogues. They are divided into A-type or C-type aurachins according to the position of the farnesyl residue either at C4 or C3 of the quinoline core, respectively.


AURACHIN B

An A-type aurachin that is quinoline N-oxide which is substituted by a methyl group at position 2, a hydroxy group at position 3, and a triprenyl group at position 4.


A-type aurachin

Any aurachin in which the farnesyl residue is positioned at C4 of the quinoline core (cf. C-type aurachin, in which the farnesyl residue is positioned at C3). C-type aurachins are converted into A-type aurachins by late stage tailoring reactions.


AURACHIN C

A C-type aurachin that is quinolin-4-one which is substituted by a hydroxy group at positions 1, a methyl group at position 2, and a triprenyl group at position 3.


A phosphine oxide in which the substituents on phosphorus are 4-carboxybut-1-yn-1-yl, methyl and 2-methoxyphenyl.


negative regulation of secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.


name: negative regulation of histamine secretion by mast cell

description: Any process that stops, prevents or reduces the frequency, rate or extent of histamine secretion by mast cell.


name: negative regulation of hormone secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.


name: negative regulation of secretion by cell

description: Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell.


name: negative regulation of peptide hormone secretion

description: Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.


name: negative regulation of peptide secretion

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.


description: Any process that activates or increases the frequency, rate or extent of positive regulation of 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway.


name: signal transduction involved in regulation of gene expression

description: Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.


phosphatidylcholine (17:0/22:6)

A phosphatidylcholine 39:6 in which the fatty acyl groups at positions 1 and 2 are specified as C17:0 and C22:6 respectively.


name: Low Grade Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is low-grade.


A glycophytoceramide having an alpha-D-galactopyranosyl residue at the O-1 position and a tetracosanoyl group attached to the nitrogen.


boron nitride nanotube

A nanotube consisting of boron nitride.


aluminium nitride nanotube

A nanotube consisting of aluminium nitride.


disulfur dinitride

An inorganic heterocyclic compound with formula N2S2 and consisting of alternating sulfur and nitrogen atoms making up a 4-membered ring structure that is virtually square and planar. It is shock-sensitive and decomposes explosively above 30degreeC.


BROMOPYRUVATE

A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is replaced by bromine. Synthetic brominated derivative and structural analog of pyruvic acid. Highly reactive alkylating agent. Anti-cancer drug


1-undecene metabolic process

description: The chemical reactions and pathways involving 1-undecene.


A beta-D-glucosyl-N-acylsphingosine in which the acyl group is specified as tetracosanoyl.


icatibant

A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acute attacks of hereditary angioedema in adult patients.


sphingoid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.


sphingoid metabolic process

description: The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.


3-keto-sphinganine metabolic process

description: The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine.


sphingosine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.


sphinganine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol.


sphinganine metabolic process

description: The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol.


phytosphingosine metabolic process

description: The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol, a constituent of many plant sphingolipids.


sphingosine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.


sphingosine metabolic process

description: The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.


sphingoid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.


phytosphingosine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol.


Guancastane diterpene from Candolleomyces candolleanus


pergolide

A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.


shikimate metabolic process

description: The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids.


shikimate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid.


A member of the class of pyrimidine ribonucleosides that is zebularine in which the double bond between positions 3 and 4 of the pyrimidone ring has been reduced to a single bond.


name: heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide

description: The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan.


glufosinate-P-ammonium

An ammonium salt resulting from the formal reaction of equimolar amounts of glufosinate-P and ammonia. A glutamine synthetase inhibitor, used as a herbicide to control annual weeds and grasses.


name: response to meiotic cell cycle checkpoint signaling

description: A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic cell cycle checkpoint signaling; contributes to a meiotic cell cycle checkpoint.


name: response to meiotic spindle assembly checkpoint signaling

description: A process that occurs in response to signals generated as a result of meiotic spindle assembly checkpoint signaling.


name: response to meiotic DNA replication checkpoint signaling

description: A process that occurs in response to signals generated as a result of meiotic DNA replication checkpoint signaling.


L-phenylalanine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.


anaerobic phenylalanine oxidation

description: The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde.


name: Classic Hydroa Vacciniforme Lymphoproliferative Disorder

description: Hydroa vacciniforme lymphoproliferative disorder characterized by the presence of self-limited papulovesicular skin lesions in sun-exposed areas. There is no involvement of internal organs. It has an indolent course and usually affects White individuals.


A polyunsaturated fatty aldehyde that is nonanal which has 3 double bonds at positions 2, 4 and 6. The configuration of the double bonds is unknown.


polyunsaturated fatty aldehyde

Any fatty aldehyde containing more than one double or triple bond located at any position in the aliphatic chain.


A polyunsaturated fatty aldehyde that is heptadecenal having three double bonds located at postions 8, 11 and 14 (the 8Z,11Z,14Z-geoisomer).


A nona-2,4,6-trienal in which all three double bonds adopt trans-configurations.


A polyunsaturated fatty aldehyde that is (2E,6E,8E,10E)-dodeca-2,6,8,10-tetraenal in which the pro-S hydrogen at position 5 has been replaced by a hydroxy group.


tetradecadienal

Any C14 polyunsaturated fatty aldehyde containing two double bonds.


octadecadienal

Any C18 polyunsaturated fatty aldehyde containing two double bonds.


A polyunsaturated fatty aldehyde that is hexadecadienal in which the two double bonds are located at positions 10 and 12 (the 10Z,12E-geoisomer).


A polyunsaturated fatty aldehyde that is octanal which has 3 double bonds at positions 2, 4 and 6. The configuration of the double bonds is unknown.


A tetradecadienal with double bonds at positions 5 and 8.


A polyunsaturated fatty aldehyde that is decanal which has undergone formal dehydrogenation to introduce trans- double bonds at the 2-3 and 4-5 positions. A product of lipid peroxidation in cell membranes and a component of cooking oil fumes.


A hexadienal that is hexanal with trans double bonds at positions 2 and 4. It is found in tomatoes, kiwi fruit, mangoes, potato chips, herbs and spices.


S-octanoyl-L-cysteine residue

An L-alpha-amino acid residue derived from S-octanoyl-L-cysteine.


name: cytoplasmic side of apical plasma membrane

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm.


name: 3-pyridinecarboxylic acid [2-(2-furanyl)-4-oxo-1-benzopyran-3-yl] ester


Stage II Childhood Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


trans-(S)-nicotine N(1')-oxide

An (S)-nicotine N(1')-oxide in which the N(1')-methyl group is on the opposite side of the pyrrolidine ring to the pyridine substituent. The major species at pH 7.3.


pyrrolidine N-oxides

Any member of the class of pyrrolidines that are substituted by an organyl group at position 1 and in which the amino group of the pyrrolidine ring has been oxidised to give the corresponding N-oxide.


nicotine N(1')-oxide

A tertiary amine oxide resulting from the oxidation of the pyrrolidine nitrogen of nicotine.


(S)-nicotine N(1')-oxide

A nicotine N(1')-oxide resulting from the oxidation of the pyrrolidine nitrogen of (S)-nicotine; major species at pH 7.3.


cis-(S)-nicotine N(1')-oxide

An (S)-nicotine N(1')-oxide in which the N(1')-methyl group is on the same side of the pyrrolidine ring as the pyridine substituent. The major species at pH 7.3.


An O-acylcarnitine compound having 2-ethylacryloyl as the acyl substituent.


name: Refractory Paranasal Sinus Squamous Cell Carcinoma

description: Paranasal sinus squamous cell carcinoma that does not respond to treatment.


name: Refractory Head and Neck Squamous Cell Carcinoma

description: A head and neck squamous cell carcinoma that does not respond to treatment.


name: Refractory Sinonasal Squamous Cell Carcinoma

description: Nasal cavity and paranasal sinus squamous cell carcinoma that does not respond to treatment.


name: Refractory Oral Cavity Squamous Cell Carcinoma

description: Oral cavity squamous cell carcinoma that does not respond to treatment.


name: Refractory Cutaneous Squamous Cell Carcinoma of the Head and Neck

description: Cutaneous squamous cell carcinoma of the head and neck that does not respond to treatment.


Hodgkin's lymphoma of small intestine

description: A Hodgkin lymphoma that arises from the small intestine.


name: Resectable Pancreatic Acinar Cell Carcinoma

description: Pancreatic acinar cell carcinoma that is amenable to surgical resection.


Pancreas carcinoma resectable

description: Carcinoma of the pancreas amenable to surgical removal.


name: Borderline Resectable Pancreatic Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma term that refers to a continuum between resectable and locally advanced unresectable disease.


Pancreatic adenocarcinoma resectable

description: Pancreatic adenocarcinoma that is amenable to surgical resection.


name: Resectable Pancreatic Ductal Adenocarcinoma

description: Pancreatic ductal adenocarcinoma amenable to surgical resection.


name: Resectable Pancreatic Adenosquamous Carcinoma

description: Pancreatic adenosquamous carcinoma that is amenable to surgical resection.


A tetrahydromethanopterin having a methanylylidene joined to the nitrogens at the 5- and 10-positions.


An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of (15R)-15-hydroxypalmitic acid with ascarylopyranose (the alpha anomer). It is a metabolite of the nematode Caenorhabditis elegans.


name: positive regulation of vitamin metabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.


name: positive regulation of cobalamin metabolic process

description: Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process.


tetranorbiotin

A member of the class of thienoimidazoles that is 2-oxohexahydrothieno[3,4-d]imidazole carrying an additional carboxy group at position 4 (the 3aS,4R,6aR-diastereomer).


thienoimidazole

Any organic heterobicyclic compound that consists of an imidazole ring -fused to a thiophene ring.


4-alpha-methyl-delta7-sterol oxidation

description: A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4-alpha-methyl-delta7-sterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy,delta7-sterol + 3 NADP+ + 3 H2O.


A member of the class of  phenols that phenol substituted by methyl groups at positions 3 and 5.


coelichelin

A tetrapeptide hydroxamate siderophore that is isolated from Streptomyces coelicolor.


fatty alcohol 20:1

Any fatty alcohol containing 20 carbons and 1 double bond.


A fatty alcohol 20:1 that is icosanol containing a double bond located at position 11 (the 11Z-geoisomer).


A ceramide phosphoinositol compound having a tetracosanoyl group amide-linked to a C20 phytosphingosine base, with hydroxylation at C-2 of the C24 very-long-chain fatty acid.


miRNA binding

description: Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.


name: Stage I Lip and Oral Cavity Cancer AJCC v8

description: Stage I includes: T1, N0, M0.  T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less depth of invasion (DOI).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th Ed.)


name: positive regulation of centriole-centriole cohesion

description: Any process that activates or increases the frequency, rate or extent of centriole-centriole cohesion.


name: regulation of centriole-centriole cohesion

description: Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker.


name: negative regulation of centriole-centriole cohesion

description: Any process that stops, prevents or reduces the frequency, rate or extent of centriole-centriole cohesion.


name: negative regulation of age-related resistance

description: Any process that stops, prevents or reduces the extent of age-related resistance.


Brain Pilocytic Astrocytoma

description: Pilocytic astrocytoma that arises from the brain.


Third Ventricle Pilocytic Astrocytoma

description: A pilocytic astrocytoma occurring in the third ventricle.


name: 2-[(5-chloro-2-thiophenyl)-oxomethyl]imino-3,4-dimethyl-5-thiazolecarboxylic acid ethyl ester


propanediol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH.


propanediol metabolic process

description: The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items.


name: anaerobic glycerol catabolic process to propane-1,3-diol

description: The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water.


name: Hemolytic anemia due to disseminated intravascular coagulation


Anemia due to membrane defect

description: A group of inherited hemolytic anemias caused by erythrocyte membrane defects. This includes hereditary pyropoikilocytosis, hereditary spherocytosis and hereditary elliptocytosis.


Immune Hemolytic Anemia

description: An acquired anemia resulting from immune-mediated destruction of the red blood cells. Causes include autoimmune disorders, blood transfusions, and drugs.


Anemia, Hemolytic, Acquired

description: Hemolytic anemia, the cause of which is not present at birth.


Infantile pyknocytosis

description: A rare, neonatal syndrome characterized by early jaundice that becomes rapidly associated with severe hemolytic anemia. The peripheral blood smear is remarkable for small irregular, contracted red blood cells with hyper-dense spikes (pyknocytes), that progressively increase in number and then spontaneously disappear.


Refractory Lymphomatoid Granulomatosis

description: Lymphomatoid granulomatosis that is resistant to treatment.


name: Angiocentric immunoproliferative lesion grade 2

description: Lymphomatoid granulomatosis characterized by the presence of occasional large lymphoid cells or immunoblasts in a polymorphous background. Necrosis is more commonly seen as compared to grade I lymphomatoid granulomatosis. By in situ hybridization, EBV-positive cells are readily seen.


name: Central Nervous System Lymphomatoid Granulomatosis

description: Lymphomatoid granulomatosis that affects the brain, spinal cord, and leptomeninges.


Cutaneous Lymphomatoid Granulomatosis

description: Lymphomatoid granulomatosis that affects the skin.


Childhood Lymphomatoid Granulomatosis

description: Lymphomatoid granulomatosis that occurs during childhood.


propionyl-CoA

An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of propionic acid.


telomere single strand break repair

description: Single strand break repair that takes place in a telomere.


description: Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins.


CINANSERIN HYDROCHLORIDE

The hydrochloride salt of cinanserin. It is an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus (SARS-Cov) and reduces virus replication in vitro.


5-fluorouridine 5'-monophosphate

A pyrimidine ribonucleoside 5'-monophosphate having 5-fluorouracil as the pyrimidine component.


name: High Grade Anal Canal Intraepithelial Neoplasia

description: Intraepithelial neoplasia involving the anal canal.  The epithelial cells exhibit moderate dysplasia (grade II intraepithelial neoplasia) or severe dysplasia (grade III intraepithelial neoplasia or carcinoma in situ).


MULTIPLOLIDE B

A 10-membered lactone obtained from 10-methyl-9,10-dihydro-2H-oxecin-2-one by the epoxidation of the double bond at position 3-4 and cis-dihydroxylation of the double bond at position 7-8, with further acylation of the hydroxy group at position 8 by a but-2-enoyl group. Multiplolide B was first isolated from the fungus Xylaria multiplex BCC 1111. It shows antifungal activity against Candida albicans. The epoxide group has cis-configuration, but its configuration relative to the other substituents was not established.


DEAMINOHYDROXYVALINE

The R-enantiomer of 2-hydroxy-3-methylbutyric acid.


name: negative regulation of meiotic chromosome separation

description: Any process that stops, prevents or reduces the frequency, rate or extent of meiotic chromosome separation.


diphenylethane

Compounds containing two phenyl groups connected by an ethyl linker.


name: 2-[[cyclohexyl(oxo)methyl]amino]acetic acid (2-oxo-1,2-diphenylethyl) ester


name: 2-phenoxyacetic acid (2-oxo-1,2-diphenylethyl) ester


name: 3-acetamidobenzoic acid [2-(4-methylphenyl)-2-oxo-1-phenylethyl] ester


name: 2-chlorobenzoic acid [2-(4-methoxyphenyl)-2-oxo-1-phenylethyl] ester


DIHYDROPINOSYLVIN

A member of the class of resorcinols carrying an additional 2-phenylethyl substituent at position 5.


benzoin

A ketone that consists of acetophenone bearing hydroxy and phenyl substituents at the alpha-position. The parent of the class of benzoins.


A diphenylethane that is  1,2-dihydrostilbene substituted by a methyl group at position 1.


A diphenylethane that is 1,2-dihydrostilbene substituted by hydroxy groups at positions 4, 4', and 5 and a methoxy groups at positions 3 and 3'. It is isolated from Dendrobium ellipsophyllum and sensitizes lung cancer cells to anoikis.


dendrocandin E

A diphenylethane that is 1,2-dihydrostilbene substituted by hydroxy groups at positions 3, 3', 4 and 4' and a methoxy group at position 5. It is isolated from the stems of Dendrobium candidum and exhibits antioxidant activity.


A diphenylethane that is the 1,2-dihydro derivative of stilbene.


A diphenylethane that is 1,2-dihydrostilbene substituted by hydroxy groups at positions 3, 3' and 5.


benzoins

An aromatic ketone containing a benzoin (2-hydroxy-1,2-diphenylethanone) skeleton.


dendrocandin D

A diphenylethane that is 1,2-dihydrostilbene substituted by hydroxy groups at positions 3, 4 and 4', a methoxy group at position 5 and an ethoxy group at alpha-position (the S stereoisomer). It is isolated from the stems of Dendrobium candidum and exhibits antioxidant activity.


dendrocandin C

A diphenylethane that is 1,2-dihydrostilbene substituted by hydroxy groups at positions 3, 4 and 4' and methoxy groups at C-5 and alpha-position respectively (the S stereoisomer). It is isolated from the stems of Dendrobium candidum and exhibits antioxidant activity.


name: HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 6

description: A lipid transport disorder characterized by extremely elevated levels of high density lipoprotein cholesterol (HDL C; HDLC). It is caused by heterozygous mutations in the SCARB1 gene that result in decreased transport of HCL C into the liver by scavenger receptor class B member 1.


A member of the class of pterocarpans that is (6aS,11aS)-3,6a,9-trihydroxypterocarpan in which the hydrogen atom at position 2 is substituted by a 3-methylbut-2-en-1-yl group.


aflatoxin B2

An aflatoxin having a hexahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.


hederacine B

An alkaloid isolated from Glechoma hederaceae.


name: 2-hydroxy-2-phenylacetic acid (1,2,6,6-tetramethyl-3-piperidinyl) ester


D-tagatose

The D-enantiomer of tagatose.


TAGATOSE

The straight-chain keto form of D-tagatose.


alpha-D-tagatopyranose

A D-tagatopyranose with an alpha-configuration at the anomeric center.


D-tagatopyranose

The pyranose form of D-tagatose.


beta-D-tagatofuranose

A D-tagatofuranose with a beta-configuration at the anomeric center.


alpha-D-tagatofuranose

A D-tagatofuranose with an alpha-configuration at the anomeric center.


D-tagatofuranose

The furanose form of D-tagatose.


beta-D-tagatopyranose

A D-tagatopyranose with a beta-configuration at the anomeric center.


carbonate ester

Any carbonate that is carbonic acid in which the hydrogens have been replaced by organyl groups.


(R)-tolpyralate

A 1-({1-ethyl-4-[3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl]-1H-pyrazol-5-yl}oxy)ethyl methyl carbonate that has R-configuration.


(S)-tolpyralate

A 1-({1-ethyl-4-[3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl]-1H-pyrazol-5-yl}oxy)ethyl methyl carbonate that has S-configuration.


A benzoylpyrazole that is 1H-pyrazole substituted by an ethyl, 3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl, and 1-[(methoxycarbonyl)oxy]ethoxy groups at positions 1, 4 and 5, respectively.


dimethyl carbonate

A carbonate ester that is carbonic acid in which both hydrogens are replaced by methyl groups. A flammable, colourless liquid (m.p. 2-4degreeC, b.p. 90degreeC) with a characterstic ester-like odour, it is used as a 'green' methylating agent and as a solvent.


azilsartan medoxomil

A carboxylic ester obtained by formal condensation of the carboxy group of azilsartan with the hydroxy group of 4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one. A prodrug for azilsartan, it is used for treatment of hypertension.


SPIROTETRAMAT

An azaspiro compound that is methoxycyclohexane which is fused at position 4 to the 5-position of a 1,5-dihydro-2H-pyrrol-2-one that is substituted at positions 3 and 4 by 2,5-dimethylphenyl and (ethoxycarbonyl)oxy groups, respectively (the cis isomer). It is a proinsecticide (via hydrolysis of the ethyl carbonate group to give the corresponding 4-hydroxypyrrol-2-one, "spirotetramat-enol") and is used for the control of a wide range of sucking insects on fruit and potato crops.


(Z)-hex-3-en-1-yl methyl carbonate

A carbonate ester that is dimethyl carbonate in which one of the methyl groups has been replaced by a (Z)-hex-3-en-1-yl group. It has a floral scent and is used in the production of fruit or vegetable-like flavour additives.


diphenyl carbonate

A carbonate ester that is the diphenyl ester of carbonic acid.


methyl 4-nitrobenzyl carbonate

A carbonate ester that is dimethyl carbonate in which one of the methyl groups has been replaced by a 4-nitrobenzyl group.


adefovir dipivoxil

An organic phosphonate that is the dipivoxil ester of adefovir. A prodrug for adefovir, an HIV-1 reverse transcriptase inhibitor, adefovir pivoxil is used to treat chronic hepatitis B viral infection.


spiropidion

An azaspiro compound that is 1-methoxypiperidine which is fused at position 4 to the 5-position of a 1,5-dihydro-2H-pyrrol-2-one that is substituted at positions 1, 3 and 4 by methyl, 4-chloro-2,6-dimethylphenyl and (ethoxycarbonyl)oxy groups, respectively. It is a proinsecticide developed by Syngenta and used to protect a wide range of crops from some of the most damaging, difficult to control sucking pests such as aphids, whiteflies, Pysllids, armoured scales, soft scales, spider mites, rust mites, and red mites including California red scale, green peach aphid (Myzus persicae), tobacco whitefly etc.


A carbonate ester resulting from the formal condensation of the hydroxy group of 5-(undeca-3,5,7-trien-1-yl)furan-2-ol with one of the hydroxy groups of carbonic acid. A metabolite of the endophytic fungus Emericellasp. XL029. The configuration of the double bonds of the undecatrienyl group is not stated.


spirobudifen

An oxaspiro compound that is 1-oxaspiro[4.5]dec-3-en-2-one substituted by 2,4-dichlorophenyl and (butoxycarbonyl)oxy groups at positions 3 and 4, respectively. It is an acaricide from Zhejiang Udragon Bioscience.


ampiroxicam

A benzothiazine that is the 1-[(ethoxycarbonyl)oxy]ethyl ether of piroxicam. A prodrug for piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.


sarcinapterin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of sarcinapterin.


sarcinapterin metabolic process

description: The chemical reactions and pathways involving sarcinapterin.


A branched amino heptasaccharide comprising a linear tetrasaccharide unit of beta-D-galactose, N-acetyl-beta-D-glucosamine, beta-D-galactose and D-glucose residues linked in a (1->4), (1->6 and (1->4) sequence, with an alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl trisaccharide unit linked (1->3) to the galactose residue proximal to the reducing end.


A 1-methyl-4-pyridone-5-carboxamide with 2 deuterium atoms replacing 2 hydrogen atoms.


A member of the class of 4-pyridones that is 4-pyridone substituted with a carboxamide group at C-3 and a methyl group at N-1.


(S)-salmeterol

2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol in which the stereocentre has S configuration.


salmeterol

A phenol having a hydroxymethyl group at C-2 and a 1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl group at C-4; derivative of phenylethanolamine.


(R)-salmeterol

2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol in which the stereocentre has R configuration.


name: tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide


name: humoral immune response mediated by circulating immunoglobulin

description: An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.


sarcosine metabolic process

description: The chemical reactions and pathways involving sarcosine.


sarcosine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of sarcosine.


sarcosine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of sarcosine.


L-amino acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of an L-amino acid.


3-cyano-L-alanine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of 3-cyano-L-alanine.


Refractory Neuroblastoma

description: A neuroblastoma that does not respond to treatment.


methylcytidine

Any member of the class of cytidines that is cytidine substituted by at least one methyl group.


cytidine

A pyrimidine nucleoside in which cytosine is attached to ribofuranose via a beta-N(1)-glycosidic bond.


capecitabine

A carbamate ester that is cytidine in which the hydrogen at position 5 is replaced by fluorine and in which the amino group attached to position 4 is converted into its N-(penyloxy)carbonyl derivative. Capecitabine is a antineoplastic agent used in the treatment of cancers.


lysidine monophosphate

A pyrimidine ribonucleoside 5'-monophosphate that is CMP in which the 2-keto group on the cytosine ring is replaced by an epsilon-L-lysyl residue.


lysidine

Cytidine in which the 2-keto group on the cytosine ring is substituted by an epsilon-Llysyl residue.


Cytidine in which one of the exocyclic amino hydrogens is substituted by an acetyl group.


A member of the class of cytidines that is a metabolite of the drug capecitabine.


isocytidines

Any member of the class of pyrimidine ribonucleosides in which the pyrimidine moiety consists of 2-amino-4-hydroxypyrimidine or its derivatives.


agmatidine

Cytidine in which the 2-keto group on the cytosine ring is substituted by the amino group of agmatine.


name: Reactive Hyperplasia of the Retinal Pigment Epithelium

description: A reactive, non-neoplastic hyperplasia of the retinal pigment epithelium.


AGA codon-amino acid adaptor activity

description: A triplet codon-amino acid adaptor activity that recognizes an AGA codon.


regulation of binding

description: Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.


regulation of protein binding

description: Any process that modulates the frequency, rate or extent of protein binding.


name: negative regulation of chemokine activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of chemokine activity.


negative regulation of protein binding

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.


regulation of microtubule binding

description: Any process that modulates the frequency, rate or extent of microtubule binding.


negative regulation of binding

description: Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.


name: modulation by host of RNA binding by virus

description: A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA.


name: negative regulation of cytokine activity

description: Any process that decreases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells.


name: negative regulation of microtubule plus-end binding

description: Any process that stops, prevents or reduces the frequency, rate or extent of microtubule plus-end binding.


ioxaglic acid

A benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an acetyl(methyl)amino group at the 5-position.


Glu-Glu-Leu

A tripeptide composed of two L-glutamic acid residues and an L-leucine residue joined in sequence by peptide linkages.


A branched amino octasaccharide comprised of a backbone of beta-D-galactosyl, N-acetyl-beta-D-glucosaminyl, alpha-D-mannosyl, beta-D-mannosyl, N-acetyl-beta-D-glucosaminyl and N-acetyl-beta-D-glucosamine residues linked in sequence (1->4), (1->2), (1->3), (1->4) and (1->4), to the beta-D-mannosyl residue is also linked (1->2) a beta-D-xylosyl residue, while the D-GlcNAc residue distal to the reducing end has also linked (1->3) to it an alpha-L-fucosyl residue.


MS023 is a type I PRMTs inhibitor.


22-hydroxydocosanoic acid

An omega-hydroxy-long-chain fatty acid obtained by monohydroxylation of the terminal methyl group of docosanoic acid.


phosphatidylethanolamine (P-18:0/18:3)

A phosphatidylethanolamine P-36:3 in which the 1-alkenyl group contains 18 carbons and no additional double bonds while the acyl group contains 18 carbons and 3 double bonds.


A linear octasaccharide glycosyl group consisisting of two N-acetylglucosamine residues, three glucuronic acid residues and two galactose residues linked to a xylosyl residue at the reducing end and which is commonly bonded to an amino acid residue.


name: geranylfarnesyl diphosphate synthase activity

description: Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate.


D-allose biosynthetic process

description: The chemical reactions and pathways resulting in the formation of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose.


(S)-Fasnall

An N-(1-benzylpyrrolidin-3-yl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine in which the chiral centre has S configuration. Both enantiomers act as fatty acid synthase inhibitors, although the (S)-enantiomer was found to be more than 4 times as active as the (R)-enantiomer.


name: CD8-positive, alpha-beta cytotoxic T cell extravasation

description: The migration of a CD8-positive, alpha-beta cytotoxic T cell from the blood vessels into the surrounding tissue.


name: CD8-positive, alpha-beta T cell extravasation

description: The migration of a CD8-positive, alpha-beta T cell from the blood vessels into the surrounding tissue.


T-helper 1 cell extravasation

description: The migration of a T-helper 1 cell from the blood vessels into the surrounding tissue. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.


T-helper 17 cell extravasation

description: The migration of a T-helper 17 cell from the blood vessels into the surrounding tissue.


spermidine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.


clavaldehyde

An organic heterobicyclic compound that is clavulanic acid in which the allylic alcohol group has been oxidised to the corresponding aldehyde.


acetohydroxamic acid

A member of the class of acetohydroxamic acids that is acetamide in which one of the amino hydrogens has been replaced by a hydroxy group.


carbohydroximic acid

A carboximidic acid having an OH or OR (R = organyl) group attached to the imide nitrogen.


name: clathrin-sculpted glutamate transport vesicle

description: A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing glutamate.


boron-10 atom

A stable isotope of boron with relative atomic mass 10.0129370, 19.9 atom percent natural abundance and nuclear spin 3+.


An (omega-1)-hydroxy fatty acid ascaroside that is ascr#24 in which the pro-R hydrogen that is beta to the carboxy group is replaced by a hydroxy group. It is a metabolite of the nematode Caenorhabditis elegans.


(omega-1)-hydroxy fatty acid ascaroside

A hydroxy fatty acid ascaroside derived from an (omega-1)-hydroxy fatty acid.


An (omega-1)-hydroxy fatty acid ascaroside that is ascr#36 in which the pro-R hydrogen that is beta to the carboxy group is replaced by a hydroxy group. It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of (2E,6R)-6-hydroxyhept-2-enoic acid with ascarylopyranose (the alpha anomer). It is a metabolite of  the nematode Caenorhabditis elegans.


A 4-O-(1H-indol-3-ylcarbonyl)ascaroside derived from (11R)-11-hydroxylauric acid.  It is a metabolite of the nematode Caenorhabditis elegans.


An ascarosyloxycarboxylic acid beta-D-glucopyranosyl ester resulting from the formal esterification of the carboxy group of ascr#20 with the anomeric hydroxy group of beta-D-glucopyranose. It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of (2E,18R)-18-hydroxynonadec-2-enoic acid with ascarylopyranose (the alpha anomer). It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of (7R)-7-hydroxyoctanoic acid with ascarylopyranose (the alpha anomer). It is a metabolite of the nematode Caenorhabditis elegans.


An ascarosyloxycarboxylic acid beta-D-glucopyranosyl ester resulting from the formal esterification of the carboxy group of ascr#22 with the anomeric hydroxy group of beta-D-glucopyranose. It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside that is bhas#24 in which the hydroxy group at position 4 of the ascarylopyranose moiety has been has been converted to the corresponding 1H-indole-3-carboxylate ester. It is a metabolite of the nematode Caenorhabditis elegans.


A 4-O-(1H-indol-3-ylcarbonyl)ascaroside derived from (10R)-10-hydroxyundecanoic acid. It is a metabolite of the nematode Caenorhabditis elegans.


A 4-O-(1H-indol-3-ylcarbonyl)ascaroside derived from (2E,6R)-6-hydroxyhept-2-enoic acid. It is a metabolite of the nematode Caenorhabditis elegans.


A 4-O-(1H-indol-3-ylcarbonyl)ascaroside derived from (8R)-8-hydroxynonanoic acid. It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of (10R)-10-hydroxyundecanoic acid with ascarylopyranose (the alpha anomer). It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside obtained by obtained by formal condensation of the alcoholic hydroxy group of (24R)-2-methylpentacosanoic acid with ascarylopyranose (the alpha anomer). It is a metabolite of the nematode Caenorhabditis elegans.


An ascarosyloxycarboxylic acid beta-D-glucopyranosyl ester resulting from the formal esterification of the carboxy group of ascr#24 with the anomeric hydroxy group of beta-D-glucopyranose. It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside that is ascr#16 in which the pro-R hydrogen that is beta to the carboxy group is replaced by a hydroxy group. It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of (8R)-8-hydroxynonanoic acid with ascarylopyranose (the alpha anomer). A metabolite of the nematode Caenorhabditis elegans, it is the direct biosynthetic precursor to ascr#3. It has also been detected in the sour paste nematode, Panagrellus redivivus.


An ascarosyloxycarboxylic acid beta-D-glucopyranosyl ester resulting from the formal esterification of the carboxy group of ascr#1 with the anomeric hydroxy group of beta-D-glucopyranose. It is a metabolite of the nematode Caenorhabditis elegans.


An ascarosyloxycarboxylic acid beta-D-glucopyranosyl ester resulting from the formal esterification of the carboxy group of ascr#10 with the anomeric hydroxy group of beta-D-glucopyranose. It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of (13R)-13-hydroxymyristic acid with ascarylopyranose (the alpha anomer). It is a metabolite of the nematode Caenorhabditis elegans.


A 4-O-(1H-indol-3-ylcarbonyl)ascaroside that is icas#10 in which the pro-R hydrogen beta to the carboxy group is replaced by a hydroxy group.  It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of (2E,12R)-12-hydroxytridec-2-enoic acid with ascarylopyranose (the alpha anomer). It is a metabolite of the nematode Caenorhabditis elegans.


A 4-O-(1H-indol-3-ylcarbonyl)ascaroside that is icas#18 in which the pro-R hydrogen beta to the carboxy group is replaced by a hydroxy group. It is a metabolite of the nematode Caenorhabditis elegans.


A 4-O-(1H-indol-3-ylcarbonyl)ascaroside derived from (12R)-12-hydroxytridecanoic acid. It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of (2E,11R)-11-hydroxydodec-2-enoic acid with ascarylopyranose (the alpha anomer). It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside that is bhas#26 in which the hydroxy group at position 4 of the ascarylopyranose moiety has been has been converted to the corresponding 1H-indole-3-carboxylate ester. It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of (2E,17R)-17-hydroxyoctadec-2-enoic acid with ascarylopyranose (the alpha anomer). It is a metabolite of the nematode Caenorhabditis elegans.


A 4-O-(1H-indol-3-ylcarbonyl)ascaroside derived from  (2E,8R)-8-hydroxynon-2-enoic acid. It is a metabolite of the nematode Caenorhabditis elegans.


A 4-O-(1H-indol-3-ylcarbonyl)ascaroside derived from (9R)-9-hydroxydecanoic acid. It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of (2E,8R)-8-hydroxynon-2-enoic acid with ascarylopyranose (the alpha anomer). It is a major component of the dauer pheromone, used by the nematode Caenorhabditis elegans as a population-density signal to promote entry into an alternate larval stage, the nonfeeding and highly persistent dauer diapause, and also synergises with ascr#2, ascr#4, and ascr#8 in male attraction.


A 4-O-(1H-indol-3-ylcarbonyl)ascaroside derived from (2E,12R)-12-hydroxytridec-2-enoic acid. It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside that is ascr#32 in which the pro-R hydrogen that is beta to the carboxy group is replaced by a hydroxy group. It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of (2E,20R)-20-hydroxyhenicos-2-enoic acid with ascarylopyranose (the alpha anomer). It is a metabolite of the nematode Caenorhabditis elegans.


An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of (12R)-12-hydroxytridecanoic acid with ascarylopyranose (the alpha anomer). It is a metabolite of the nematode Caenorhabditis elegans.