name: Metastatic Vulvar Squamous Cell Carcinoma

description: Vulvar squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


name: Verrucous carcinoma of the oral cavity stage III

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


Conjunctival Junctional Nevus

description: A junctional nevus that arises from the conjunctiva. It occurs almost exclusively in the juxtalimbal bulbar conjunctiva. It is characterized by an intraepithelial proliferation of type A nevus cells and/ or type B nevus cells.


Grade III Childhood Astrocytoma

description: An anaplastic astrocytoma that arises from the central nervous system and occurs during childhood.


name: Locally Advanced Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: Extrapulmonary small cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Monomorphic T/NK-Cell Post-Transplant Lymphoproliferative Disorder

description: A clonal T-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed T-lymphocytes/NK-cells.  The clonal cellular infiltrates fulfill the criteria for any of the T-cell or natural killer cell lymphomas.


name: Esophageal and Gastroesophageal Junction Carcinoma

description: A carcinoma that arises from the esophagus or gastroesophageal junction.


De Novo Nodular Melanoma

description: A nodular melanoma that does not arise from a nevus and lacks a radial growth phase.


Refractory Squamous Cell Carcinoma

description: Squamous cell carcinoma that is resistant to treatment.


Congenital Adrenal Gland Disorder

description: A genetic disorder that affects the adrenal gland.  It includes adrenal gland hyperplasia and adrenal gland hypoplasia.


Non-Neoplastic Gonadal Disorder

description: A non-neoplastic disorder that affects the testis or the ovary. Representative examples include gonadal agenesis, dysgenesis, and hypogonadism.


name: Stage IV Renal Pelvis and Ureter Cancer AJCC v7

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat.  N0: No regional lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  N1: Distant metastasis.  (AJCC 7th ed.)


Schizophrenia, Childhood

description: Schizophrenia occurring in childhood.


Invasive Prostate Carcinoma

description: A carcinoma that is not confined to the prostatic epithelium but has spread to the surrounding stroma of the prostate gland.  The vast majority of invasive prostate carcinomas are adenocarcinomas.


Retroperitoneal disorder

description: A non-neoplastic or neoplastic disorder that affects the retroperitoneum.


Non-Neoplastic Anal Disorder

description: A non-neoplastic disorder that affects the anus. Representative examples include hemorrhoids, ulcers, and infections.


name: Clear Cell Tumor with Melanocytic Differentiation and ACTG1-MITF Translocation

description: A clear cell tumor with melanocytic differentiation characterized by a cytogenetic translocation between ACTG1 and MITF genes that results in ACTG1-MITF gene fusion.


name: Benign Accessory Urethral Gland Neoplasm

description: A neoplasm that arises from the accessory urethral glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Stage II Non-Contiguous Adult Diffuse Mixed Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Childhood Ependymal Tumor

description: An ependymal tumor that occurs during childhood.


name: Recurrent Fallopian Tube High Grade Serous Adenocarcinoma

description: The reemergence of fallopian tube high-grade serous adenocarcinoma after a period of remission.


Stage II Anal Cancer AJCC v8

description: Stage II includes: IIA: T2, N0, M0; IIB: T3, N0, M0. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. T3: Tumor larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IV Pancreatic Cancer AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Stage M2 Childhood Ependymoma by Toronto Guidelines v2

description: Visible metastasis in brain. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Aggressive Prostate Adenocarcinoma

description: Prostate adenocarcinoma that metastasizes quickly to other anatomic sites. It usually has a Gleason score between 8 and 10, a PSA level higher than 20 ng/ml, and is classified as T3b or T4.


name: Stage IVC Oral Cavity Verrucous Carcinoma


name: Autosomal Dominant Congenital Myopathy-1A

description: An autosomal dominant condition caused by mutation(s) in the RYR1 gene, encoding ryanodine receptor 1. The phenotype is variable, but generally includes weakness in the proximal muscles of the lower limb and individuals are at increased risk for malignant hyperthermia.


Kidney Neuroendocrine Neoplasm

description: An epithelial neoplasm with neuroendocrine differentiation that arises from the kidney.  It includes neuroendocrine tumor, small cell neuroendocrine carcinoma, large cell neuroendocrine carcinoma, and paraganglioma.


Cancer-Associated Anorexia

description: Loss of appetite associated with cancer or its treatment.


Locally Advanced Merkel Cell Carcinoma

description: A Merkel cell carcinoma that has spread to nearby tissues or lymph nodes.


Chronic Right Heart Failure

description: Persistent and long-standing right heart failure.


Advanced Mucosal Melanoma

description: Mucosal melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Metastatic malignant neoplasm to peritoneum

description: The spread of a malignant neoplasm to the peritoneum from another primary anatomic site.


Schizophrenia, Disorganized

description: A subtype of schizophrenia characterized by disorganized speech, disorganized behavior, and a flat or inappropriate affect; associated features include grimacing, mannerisms, and other oddities of behavior. Criteria for the catatonic type of schizophrenia are not met.


name: Cervical Stratified Mucin-Producing Intraepithelial Lesion

description: A rare, human papillomavirus-associated premalignant glandular intraepithelial neoplasm that arises from the cervix. It is characterized by the presence of stratiﬁed, immature epithelial cells containing varying quantities of intracytoplasmic mucin. There is no evidence of stromal invasion. It is distinct from conventional cervical squamous or glandular intraepithelial neoplasias.


Metanephric Tumor

description: A neoplasm arising from the distal convoluted tubule and collecting duct areas of the kidney.


Localized Neoplasm

description: A neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Benign neuroendocrine tumor

description: A paraganglioma that is confined to the site of origin.


Lichenoid Actinic Keratosis

description: Actinic keratosis characterized by the presence of a band-like chronic inflammatory infiltrate in the papillary dermis and vacuolar changes in the basal keratinocytes.


Continent Epispadias

description: Epispadias with urinary continence.


name: Ann Arbor Stage I Supradiaphragmatic Hodgkin Lymphoma


name: stenosis of supravalvular pulmonary artery

description: Stenosis of the pulmonary artery that occurs above the valve.


Abscess of adrenal gland

description: An abscess that is located in the adrenal gland.


Stage I Esophageal Cancer

description: Stage I includes: T1, N0, M0.  TI: Tumor invades lamina propria or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) -2003


Enteropathic spondylitis

description: A form of spondyloarthritis that is found in some patients with inflammatory bowel disease.


Adult Acute Erythroid Leukemia

description: An acute erythroid leukemia occurring in adults.


name: Cervical Adenocarcinoma, Not Otherwise Specified

description: A cervical adenocarcinoma that cannot be classified by WHO criteria or International Endocervical Adenocarcinoma Criteria and Classification (IECC).


Stage IS Testicular Cancer AJCC v8

description: Stage IS includes: Any pT/TX, N0, M0, S1-3. TX: Testicular cancer in which the primary tumor cannot be assessed. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. S2: LDH 1.5-10 x N or hCG (mlU/mL) 5,000-50,000 or AFP (ng/mL) 1,000-10,000. S3: LDH more than 10 x N or hCG (mlU/mL) more than 50,000 or AFP (ng/mL) more than 10,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Senile Sebaceous Hyperplasia

description: A hyperplasia of the sebaceous glands. It is usually seen as small yellow papules in the face of middle aged-older population.


Malignant blue nevus of skin

description: A rare melanoma which develops in a pre-existing blue nevus. It occurs more frequently on the scalp, face, orbit, back, buttocks, extremities, hands, and feet.


Thoracic Diseases

description: A non-neoplastic or neoplastic disorder that affects the thorax and/or the organs of the thoracic cavity.  Representative examples include pleural infection, mediastinitis, thymoma, mediastinal lymphoma, and pleural mesothelioma.


Localized Esophageal Carcinoma

description: Esophageal carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites.


Appendix Traditional Serrated Adenoma

description: An adenoma that arises from the appendix.  It is characterized by prominent serration of the glands.


Sign

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Objective evidence of disease perceptible to the examining healthcare provider.


Delusional disorder, mixed type

description: A subtype of delusional disorder applied when no one delusional theme (such as grandiose, jealous, persecutory) predominates.


name: Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that arises from an anatomic site other than the lung.


name: Clinical Stage III Cutaneous Melanoma AJCC v8

description: Stage III includes: Any T, Tis, N1 or More, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N1: One tumor-involved node or in-transit, satellite, and/or microsatellite metastases with no tumor-involved nodes. N2: Two or three tumor-involved nodes or in-transit, satellite, and/or microsatellite metastases with one tumor-involved node. N3: Four or more tumor-involved nodes or in-transit, satellite, and/or microsatellite metastases with two or more tumor-involved nodes, or any number of matted nodes without or with in-transit, satellite, and/or microsatellite metastases. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Recurrent Plasma Cell Leukemia

description: The reemergence of plasma cell leukemia after a period of remission.


Gliomatosis Cerebri Type I

description: A classic form of gliomatosis cerebri. It is characterized by diffuse growth of neoplastic glial tissue without any focal mass.


Refractory Glioma

description: Glioma that does not respond to treatment.


Acute Myeloid Leukemia with FUS-ERG

description: Acute myeloid leukemia associated with FUS-ERG gene fusion. The prognosis is poor.


name: Splenic marginal zone lymphoma stage III


Clotting of extracorporeal circuit

description: Thrombus formation within an apparatus that carries blood outside of the body, such as pheresis, dialysis or extracorporeal membrane oxygenation (ECMO).


name: Regional Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that has not spread to other regions.


Chronic iridocyclitis

description: Uveitis that is usually insidious in onset, bilateral, and can be asymptomatic, most often affecting the anterior uveal tract, including the iris and ciliary body, and can result in long-term complications. It is most commonly associated with certain forms of juvenile idiopathic arthritis, but may occur independent of arthritis.


Castration-Sensitive Prostate Carcinoma

description: Metastatic prostatic carcinoma which is sensitive to androgen-deprivation therapy.


name: Stage I Adult Diffuse Mixed Cell Lymphoma

description: Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


Benign tumor of seminal vesicle

description: A neoplasm that arises from the seminal vesicle and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Ectopic adrenal cortex

description: A term that refers to the presence of benign adrenal cortical tissue outside the adrenal glands.


Conjunctival Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the conjunctiva.


Carcinomatosis

description: Carcinoma that has spread diffusely to an anatomic site or throughout the body.


name: Cervical intraepithelial neoplasia grade 2

description: Cervical squamous intraepithelial neoplasia characterized by the presence of maturation in the upper half of the squamous epithelium and conspicuous nuclear atypia which is present in all epithelial layers.  Mitotic figures are present in the basal two thirds of the epithelium.


Prostate cancer stage A

description: A clinically undetectable tumor confined to the prostate gland, normally an incidental finding during surgery.


name: Autoimmune Lymphoproliferative Syndrome-Related Lymphoma

description: A lymphoma that arises in the context of autoimmune lymphoproliferative syndrome.


Melanotic neurofibroma

description: A rare neurofibroma characterized by the presence of melanin-laden cells and the absence of atypia.


Apocrine Poroma

description: A poroma with apocrine differentiation.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Tier 2, Children's Oncology Group (COG) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the tier 2 Toronto childhood cancer staging guidelines v2, Children's Oncology Group (COG) protocol.


Solid carcinoma

description: A carcinoma morphologically characterized by the presence of solid sheets of malignant epithelial cells in tissues.


Pancreatic Cystic Neoplasm

description: A benign, borderline, or malignant cystic neoplasm that arises from the exocrine pancreas. This category includes pancreatic mucinous-cystic neoplasms, pancreatic cystadenomas, and pancreatic cystadenocarcinomas.


Maturing Ganglioneuroma

description: A ganglioneuroma characterized by the presence of differentiating neuroblasts, maturing and mature ganglion cells.


Unresectable Paraganglioma

description: Paraganglioma that is not amenable to surgical resection.


Stage III Osteosarcoma AJCC v7

description: Stage III includes: T3, N0, M0, G3, G4. T3: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Nodular Neoplasm

description: A benign or malignant neoplasm characterized by the formation of nodules by the proliferating neoplastic cells.


name: Stage IV Adult Diffuse Mixed Cell Lymphoma

description: Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)


Candidal endocarditis

description: Endocarditis caused by fungal infection with Candida species.


name: Metastatic Childhood Malignant Bone Neoplasm by Toronto Guidelines v2

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Refractory Acute Myeloid Leukemia, Myelodysplasia-Related

description: Acute myeloid leukemia, myelodysplasia-related that is resistant to treatment.


Bilateral Thalamic Glioma

description: A glioma affecting both sides of the thalamus.


Solid Angioleiomyoma

description: A morphologic variant of angioleiomyoma characterized by the presence of numerous small, slit-like vascular channels.


name: Childhood Pancreatic Acinar Cell Cystadenocarcinoma

description: An acinar cell cystadenocarcinoma that arises from the pancreas during childhood.


Air Embolism

description: The presence of bubbles of air in the vascular system; occurrence is related to the entry of air into the venous circulation following trauma or surgery.


name: Hematologic Neoplasm with Germline Predisposition Associated with a Constitutional Platelet Disorder

description: Hematologic neoplasms associated with germline mutations and familial platelet disorders.


Primary Neoplasm

description: A tumor at the original site of origin.


name: Pathologic Stage IIB Cutaneous Melanoma AJCC v8

description: Stage IIB includes: (T3b, N0, M0); (T4a, N0, M0). T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Adult Acute Promyelocytic Leukemia with PML-RARA

description: An acute promyelocytic leukemia with t(15;17)(q24.1;q21.2); PML-RARA occurring in adults.


Carcinoma of urinary bladder, invasive

description: A carcinoma that arises from the bladder mucosa and invades the bladder wall.


Infiltrating Cervical Carcinoma

description: A carcinoma that arises from the cervix and invades into the stromal tissue.


name: Invasive Clear Cell (Glycogen-Rich) Urothelial Carcinoma

description: An invasive urothelial carcinoma characterized by the presence of clear (glycogen-rich) cells.


Proximal Urethral Carcinoma

description: A carcinoma that arises from the proximal part of the urethra.


Foveolar hyperplasia

description: A hyperplasia of the gastric foveolar epithelium.


name: Diffuse Low Grade Glioma, FGFR1 Tyrosine Kinase Domain-Duplicated

description: Diffuse low-grade glioma characterized by internal tandem duplications of the sequences in the FGFR1 gene encoding the tyrosine kinase domain.


name: Endometrial Endometrioid Adenocarcinoma with Metaplastic Changes


name: Hepatocyte Nuclear Factor 1-Alpha Hyperinsulinism

description: Hyperinsulinism due to mutation(s) in the gene HNF1A, encoding the transcription factor hepatocyte nuclear factor 1-alpha. This condition may progress to diabetes later in life.


name: Localized Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Tumor confined to area of origin including abdominal lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Antepartum Obstetric Air Embolism

description: Presence of a large air bubble in the maternal vascular system which originated from a distant site during the antepartum period.


Examination phobia

description: An overwhelming, irrational, and persistent fear of taking and failing tests.


Borderline Uterine Ligament Neoplasm

description: A rare borderline tumor that arises from the broad or other uterine ligaments. The majority of the reported cases are serous cystic tumors.


Adult L1 Acute Lymphoblastic Leukemia

description: L1 acute lymphoblastic leukemia that occurs during adulthood.


Mucolipidosis Type IIIA

description: A lysosomal storage disease characterized by multiple bone formation abnormalities, progressive joint stiffness, developmental abnormalities, hearing loss, hepatosplenomegaly, increased acne, enlarged tongue, and cornea clouding due to accumulation of lipid substances.


name: Posterior Fossa Ependymoma, Not Elsewhere Classified

description: A circumscribed ependymoma that arises in the posterior fossa in which molecular analysis for DNA methylation profiling cannot assign a molecular group.


Non-Neoplastic Stomach Disorder

description: A non-neoplastic disorder that affects the stomach. Representative examples include gastritis and ulcer.


Unresectable Merkel Cell Carcinoma

description: Merkel cell carcinoma that is not amenable to surgical resection.


Poorly Differentiated Angiosarcoma

description: An angiosarcoma characterized by the presence of significant cytologic atypia, necrosis and high mitotic activity.


name: Genitourinary tract gonococcal infection

description: A genitourinary infection that is caused by Neisseria gonorrhoeae.


Adult Pineal Gland Astrocytoma

description: A pineal gland astrocytoma that occurs during adulthood.


Ulcer of nipple

description: Ulcer that develops in the nipple.  Causes include trauma and Paget disease.


Acquired Unilateral Cataract

description: A cataract in one eye that results from the aging process, an injury, or as a manifestation of a systemic disorder.


High Grade Appendix Mucinous Neoplasm

description: A rare appendix mucinous neoplasm characterized by the presence of neoplastic epithelial cells with high grade features.


Stage IB3 Cervical Cancer AJCC v9

description: Stage IB3 includes: T1b3, N0, M0. T1b3: Tumor measuring more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Bilateral Malignant Neoplasm

description: A malignant neoplasm that affects both sides of an organ in a simultaneous or non-simultaneous manner.


End stage cardiac failure

description: The terminal phase of heart failure in patients. The disease course may have progressed despite intervention and may be characterized by dyspnea, fatigue, and weakness.


Thoracic myelocele

description: Herniation of spinal cord tissue and meninges through a defect in the thoracic region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


Stage II Uterine Corpus Cancer AJCC v6

description: Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIB (T2b, N0, M0).  T2: Tumor invades cervix but does not extend beyond uterus.  T2a: Tumor limited to the glandular epithelium of the endocervix.  There is no evidence of connective tissue stromal invasion.  T2b: Invasion of the stromal connective tissue of the cervix.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Refractory Glioblastoma

description: A glioblastoma that is resistant to treatment.


Prostate Cancer by AJCC v6 Stage

description: A term that refers to the staging of prostate carcinoma according to the American Joint Committee on Cancer, 6th edition.


Prostatic Infection

description: An acute or chronic infectious process affecting the prostate gland.


Benign Liver Epithelial Neoplasm

description: A neoplasm that arises from the hepatocytes or intrahepatic bile duct epithelial cells and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include hepatocellular adenoma and bile duct adenoma.


name: Metastatic Endometrial Serous Adenocarcinoma

description: An endometrial serous adenocarcinoma that has spread to other anatomic sites.


name: Abdominal and gastrointestinal infections

description: An infection that affects the gastrointestinal system and the abdomen.


name: Metastatic Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Distant metastases present at diagnosis. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Recurrent Uterine Corpus Cancer

description: The reemergence of uterine corpus cancer after a period of remission.


name: Locally Recurrent Anal Canal Squamous Cell Carcinoma

description: The reemergence of anal canal squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Lymphangioma circumscriptum

description: A localized lymphangioma characterized by microcystic changes.


name: Glandular intraepithelial neoplasia, low grade


Refractory Malignant Mesothelioma

description: Malignant mesothelioma that is resistant to treatment.


anaplastic carcinoma of ureter

description: Undifferentiated carcinoma that affects the ureter.


name: Atypical Small Acinar Proliferation of the Prostate Gland

description: Focal proliferation of small acinar glandular cells in the prostate gland with cytologic changes ranging from atypia to highly suggestive of malignancy.


Stage IV Gastric Cancer AJCC v6

description: Stage IV includes: (T4, N1-3, M0); (T1-3, N3, M0); (Any T, Any N, M1).  M1:Distant metastasis. (AJCC 6th ed.)


name: Invasive Giant Cell Urothelial Carcinoma

description: An invasive urothelial carcinoma characterized by the presence of giant cells.


name: Prostate Carcinoma Metastatic in the Pelvic Cavity

description: A carcinoma that arises from the prostate gland and has spread to the pelvic cavity.


Recurrent Oligodendroglioma

description: The reemergence of oligodendroglioma after a period of remission.


name: Stage IV Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Hematogenous metastases or spread beyond abdomen at diagnosis. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Cesarean wound disruption

description: Asymptomatic separation of the uterine wall, usually at the site of a prior uterine scar, that does not include the overlying serosa.


Male Reproductive System Carcinoma

description: A malignant neoplasm that arises from the epithelium of any part of the male reproductive system. Representative examples include prostate carcinoma and penile carcinoma.


Affective Disorders, Psychotic

description: The manifestation of psychotic symptoms, such as hallucinations or delusions, in the presence of a mood disorder.


Holorachischisis

description: A form of the neural tube defect spina bifida in which the entire spinal column is open.


name: Diffuse Pediatric-Type High Grade Glioma RTK2

description: An aggressive, WHO grade 4 diffuse glioma usually affecting children, adolescents, or young adults. It is characterized by receptor tyrosine kinase type 2 (RTK2) alterations.


name: Stage IV Intermediate Grade Adult Non-Hodgkin's Lymphoma


name: Lugano Classification Stage I Adult Lymphoma AJCC v8

description: Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


Stage III Cervical Cancer AJCC v8

description: Stage III includes: T3, Any N, M0. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. M0: No distant metastasis. (AJCC 8th Ed.)


name: Squamous cell carcinoma, large cell, nonkeratinizing

description: A squamous cell carcinoma composed of large atypical cells, without morphologic evidence of keratin production.


Stage II Esophageal Cancer

description: Stage II includes: IIA: (T2, N0, M0); (T3, N0, M0) and IIB: (TI, NI, M0); (T2, NI, M0).  TI: Tumor invades lamina propria or submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades adventitia. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) -2003


Conjunctival Melanocytic Neoplasm

description: A melanocytic neoplasm that arises from the conjunctiva. This category includes conjunctival nevus, conjunctival melanocytic intraepithelial lesions, and conjunctival melanoma.


name: Benign Lacrimal Drainage System Neoplasm

description: A neoplasm that arises from the lacrimal drainage system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Hepatobiliary Inflammation

description: An inflammatory process affecting the liver, bile ducts and gallbladder.


name: Gastroesophageal Junction Adenocarcinoma by AJCC v8 Clinical Stage

description: A term that refers to the clinical staging of gastroesophageal junction adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Diffuse Midline Glioma, EGFR-Mutant

description: A diffuse midline glioma, H3 K27-altered, characterized by the presence of EGFR gene mutation.


Mucosal Infection

description: An acute or chronic infectious process affecting a mucosal surface.


name: Dyskeratosis Congenita, Autosomal Recessive 3

description: Dyskeratosis congenita caused by autosomal recessive mutation(s) in the WRAP53 gene, encoding telomerase Cajal body protein 1.


Stage IIIC2 Cervical Cancer AJCC v9

description: Stage IIIC2 includes: TX, T0, T1-3, N2, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N2: Tumor with regional lymph node metastasis to para-aortic lymph nodes with or without positive pelvic lymph nodes. M0: No distant metastasis. (from AJCC 9th Ed.)


Breast Adenohibernoma

description: A breast hamartoma characterized by the presence of brown fat that contains entrapped glands.


name: Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

description: An acute lymphoblastic leukemia that originates from pre-B lymphocytes. The pre-B lymphoblasts contain cytoplasmic immunoglobulin.


Stage IIA Prostate Cancer AJCC v8

description: Stage IIA includes: (cT1a-c, cT2a, N0, M0, PSA equal or more than 10 and less than 20, Grade Group 1); (cT2b-c, N0, M0, PSA less than 20, Grade Group 1). cT1a: Prostate cancer in which the tumor is an incidental histologic finding in 5% or less of tissue resected. cT1b: Prostate cancer in which the tumor is an incidental histologic finding in more than 5% of tissue resected. cT1c: Prostate cancer in which the tumor is identified by needle biopsy found in one or both sides, but not palpable. cT2a: Prostate cancer in which the tumor involves one-half of one side or less. cT2b: Prostate cancer in which the tumor involves more than one-half of one side but not both sides. cT2c: Prostate cancer in which the tumor involves both sides. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. (AJCC 8th ed.)


Anal Cancer by AJCC v8 Stage

description: A term that refers to the staging of anal cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to all carcinomas arising in the anal canal, including carcinomas that arise within anorectal fistulas and those arising in the perianal area (anal margin). High-grade neuroendocrine carcinomas (small cell neuroendocrine carcinoma and large cell neuroendocrine carcinoma) are staged using this system. There is no AJCC staging system for anal mucosal melanomas and anal well-differentiated neuroendocrine tumors. (from AJCC 8th Ed.)


name: Well Differentiated Prostate Adenocarcinoma

description: An invasive prostate adenocarcinoma characterized by the presence of well differentiated malignant glandular epithelial components.


Primary Cutaneous Hodgkin Lymphoma

description: Hodgkin lymphoma primarily involving the skin.  This diagnosis can only be made when there is no evidence of Hodgkin lymphoma in the lymph nodes or other anatomic sites.  Patients usually present with papules or nodular lesions.  Morphologically, primary cutaneous Hodgkin lymphoma may resemble lymphomatoid papulosis or anaplastic large cell lymphoma.  Immunohistochemical tissue evaluation is essential in establishing the diagnosis.


name: Human Papillomavirus-Related Cervical Adenocarcinoma

description: A cervical adenocarcinoma associated with the presence of human papillomavirus infection.


Mucocele of gallbladder

description: The enlargement of the gallbladder secondary to prolonged obstruction of the cystic duct.


Biliary Tract Carcinoma

description: A carcinoma arising from the intrahepatic bile ducts, hepatic ducts, common bile duct, cystic duct, or gallbladder.


Pancreatic Teratoma

description: A teratoma that arises from the pancreas.


Tobacco Induced Hyperparakeratosis

description: Hyperparakeratosis of the oral mucosa caused by chronic tobacco use.  It manifests as oral leukoplakia.


name: Locally Advanced Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: COL1A1 Associated Connective Tissue Disorder

description: A group of connective tissue disorder caused by mutations in the COL1A1 gene mapped to chromosome 17q21. It includes the Ehlers-Danlos syndrome, osteogenesis imperfecta, and osteoporosis.


Stage 0 Esophageal Cancer AJCC v6

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.)


Splenic Infection

description: An infectious process affecting the spleen. Predisposing factors include immunosuppression, diabetes mellitus, and sickle cell anemia. Infectious agents include bacteria (e.g., staphylococcus and streptococcus) and fungi.


name: High Grade Corneal Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process with high-grade dysplastic features involving the corneal epithelium.


description: An endometrial carcinoma that has a documented response to platinum-based chemotherapy.


Skin Verrucous Carcinoma

description: A verrucous carcinoma that arises from the skin. It usually affects the palms, soles, and distal digits.


Glucose-6-Phosphatase 3 Deficiency

description: An autosomal recessive inherited disorder caused by mutations in the G6PC3 gene. It is characterized by the absence or presence of very low levels of glucose-6-phosphatase 3. Patients may develop severe congenital neutropenia.


name: Conventional Follicular Dendritic Cell Sarcoma

description: Follicular dendritic cell sarcoma that is not associated with Epstein-Barr virus.


Breast fibroadenolipoma

description: A benign, circumscribed and usually encapsulated lesion of the breast.  It contains all the components of the breast tissue.


name: Unresectable Primary Central Nervous System Neoplasm

description: A primary central nervous system neoplasm that is not amenable to surgical resection.


Prostate Intraductal Carcinoma

description: An intra-acinar and/or intraductal neoplastic epithelial proliferation in the prostate gland that has some features of high-grade prostatic intraepithelial neoplasia but exhibits much greater architectural and/or cytological atypia, typically associated with high-grade, high-stage prostate carcinoma. (WHO 2016)


Resectable Osteosarcoma

description: Osteosarcoma that is amenable to surgical resection.


name: Ionizing Radiation-Related Malignant Neoplasm

description: A malignant neoplasm arising in an anatomic site exposed to ionizing radiation.


Fascial fibrosarcoma

description: A malignant fibroblastic neoplasm arising from the fascial connective tissue.


name: Transplant-Related Bladder Urothelial Carcinoma

description: A bladder urothelial carcinoma that arises in a patient with a history of organ transplantation.


Vaginal Basaloid Carcinoma

description: A squamous cell carcinoma that arises from the vagina and is characterized by the presence of nests of malignant basaloid squamous cells with scant amounts of cytoplasm.


name: Ventral Hernia with Obstruction without Mention of Gangrene

description: The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the linea alba, which results in obstruction, without mention of necrosis of the herniated contents.


name: Autosomal Dominant Neurohypophyseal Diabetes Insipidus

description: An autosomal dominant form of diabetes insipidus caused by mutation(s) in the AVP gene encoding arginine vasopressin.


Advanced Bone Sarcoma

description: A bone sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Metastatic Lipid-Rich Urothelial Carcinoma

description: Lipid-rich urothelial carcinoma that has spread to another anatomic site.


Stage IV Fallopian Tube Cancer AJCC v8

description: Stage IV includes: Any T, Any N, M1: M1: Distant metastasis, including pleural effusion with positive cytology; liver or splenic parenchymal metastasis; metastasis to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); and transmural involvement of intestine. (from AJCC 8th Ed.)


name: Recurrent Vulvar Squamous Cell Carcinoma

description: The reemergence of vulvar squamous cell carcinoma after a period of remission.


Metastatic Anal Carcinoma

description: Anal carcinoma that has spread from its primary site to another anatomic site.


name: Undifferentiated Fallopian Tube Carcinoma

description: An invasive carcinoma arising from the fallopian tube. It is characterized by the presence of a diffuse malignant infiltrate that is composed of epithelial cells without evidence of glandular or squamous differentiation.


Transfusion dependent thalassaemia

description: Thalassemia that results in severe anemia and requires regular blood transfusions for patient survival.


name: Metastatic malignant neoplasm to nervous system

description: The spread of a malignant neoplasm to the nervous system.  This may be from a primary nervous system malignant neoplasm, or from a malignant neoplasm at a distant site.


name: Stage III Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of lymph node regions on both sides (above and below) of the diaphragm. This may be accompanied by extra-lymphatic extension in association with adjacent lymph node involvement (i.e., local extension from a lymph node area into a nearby organ) and/or involvement of spleen. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: large cell neuroendocrine carcinoma of anal canal

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal.  It is characterized by the presence of malignant large cells.


Appendix Mucinous Neoplasm

description: An appendiceal neoplasm characterized by mucinous epithelial proliferation with extracellular mucin and pushing tumour margins. (WHO 2019)


Primary Immune Regulatory Disorder

description: A group of immune diseases characterized predominantly by immune dysregulation leading to organ-specific autoimmunity, excessive inflammation, and non-malignant lymphoproliferation. Unlike classical primary immunodeficiencies, susceptibility to infections is typically less prominent in these disorders.


name: acute myelomonocytic leukemia in relapse

description: The reemergence of acute myelomonocytic leukemia after a period of remission.


name: Bile Duct Intraductal Papillary Neoplasm with Intermediate Grade Intraepithelial Neoplasia

description: An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts. It is characterized by the presence of moderate epithelial atypia.


Stage IVA Fallopian Tube Cancer AJCC v8

description: Stage IVA includes: Any T, Any N, M1a. M1a: Fallopian tube cancer with pleural effusion with positive cytology. (from AJCC 8th Ed.)


Retinoma

description: A rare, unilateral or bilateral benign neoplasm that arises from the retina. There is an increased risk of malignant transformation to retinoblastoma; therefore, patients with a diagnosis of retinocytoma should be closely observed.


Intra-Abdominal Lymphangioma

description: A lymphangioma arising from the organs of the abdominal cavity.


name: Extrahepatic Bile Duct Neuroendocrine Neoplasm

description: A neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


name: Epithelioid Malignant Peripheral Nerve Sheath Tumor of the Skin

description: An epithelioid malignant peripheral nerve sheath tumor that arises from the skin.


Refractory Brain Neoplasm

description: Brain neoplasm that is resistant to treatment.


Idiopathic Basal Ganglia Calcification

description: Basal ganglia calcification for which no underlying cause can be identified.


Extracutaneous Merkel Cell Carcinoma

description: A rare Merkel cell carcinoma that arises from extracutaneous sites, including the oral cavity, salivary glands, breast, vulva, and vaginal wall.


name: Stage I Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of a single lymph node region or involvement of a single extra-lymphatic organ or site, without lymph node involvement. This definition applies to both tiers (tier 1 and 2).  (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Lipomatous hamartoma

description: A benign hamartomatous lesion composed predominantly of adipose tissue.


Adenocarcinoma in situ in a polyp

description: An adenocarcinoma arising in a polyp.


Appendix Tubular Adenoma

description: An adenoma arising from the appendix.  It is characterized by the presence of tubular epithelial structures and it is associated with dysplasia.


name: Refractory Childhood Acute Myeloid Leukemia

description: Childhood acute myeloid leukemia that does not respond to treatment.


name: Acute Myeloid Leukemia with t(11;19)(q23.3;p13.3); KMT2A-MLLT1

description: An acute myeloid leukemia associated with t(11;19)(q23.3;p13.3) resulting in KMT2A-MLLT1 gene fusion. It usually affects infants and children.


Indolent T-Lymphoblastic Proliferation

description: A non-neoplastic T-cell lymphoproliferation that may mimic T-lymphoblastic lymphoma. It usually involves the lymphoid tissues of the upper aerodigestive tract. It recurs locally, but systemic dissemination is rare.


name: Stage IIB Esophageal Adenocarcinoma AJCC v7

description: Stage IIB includes: (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Recurrent Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A

description: The reemergence of acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A after a period of remission.


Recurrent Lymphoproliferative Disorder

description: The reemergence of a lymphoproliferative disorder after a period of remission.


Recurrent Digestive System Carcinoma

description: The reemergence of carcinoma in any part of the digestive system after a period of remission.


Blennorrhagic arthritis

description: A form of reactive arthritis that is associated with lesions on both the palms of the hands and the soles of the feet.


name: Metastatic Distal Esophagus Adenocarcinoma

description: Distal esophagus adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Invasive Bladder Urothelial Carcinoma with Glandular Differentiation

description: An invasive urothelial carcinoma of the bladder that exhibits glandular differentiation.


Myelophthisis

description: A condition resulting from the destruction of bone marrow precursor cells and their stroma. Bone marrow is displaced by fibrosis, tumors, or granulomas.


Congenital Unilateral Cataract

description: Cataract in one eye that is present at birth.


Keratitis caused by infection

description: Inflammation of the cornea secondary to an infectious process.


Craniopharyngioma malignant

description: A rare condition characterized by the development of a carcinoma in a pre-existing craniopharyngioma.


Stage III Adult Hodgkin Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Localized Carcinoma

description: A carcinoma that is confined to a specific site without evidence of spread to other anatomic sites.


Childhood Malignant Glioma

description: A malignant glioma that occurs during childhood.


name: Stage I Adult Diffuse Large Cell Lymphoma

description: Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


name: Gastric Pylorus Carcinoma In Situ AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial tumor without invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Hodgkin's disease, nodular sclerosis - mixed cellularity

description: Nodular sclerosis Hodgkin lymphoma in which at least 75% of the tumor nodules contain scattered Reed-Sternberg cells. The background cellular infiltrate is lymphocytic, mixed, or fibrohistiocytic.


name: Recurrent T-Cell Prolymphocytic Leukemia

description: The reemergence of T-cell prolymphocytic leukemia after a period of remission.


Cheilognathouranoschisis

description: A congenital abnormality consisting of a fissure in the midline of the lip, hard and/or soft palate and upper jaw.


name: Lymphocyte Predominant Type Hodgkin's Disease

description: An antiquated term that refers either to nodular lymphocyte predominant Hodgkin lymphoma or to lymphocyte-rich classical Hodgkin lymphoma.


Cerebellar Peduncle Neoplasm

description: A benign or malignant neoplasm that affects the cerebellar peduncle.


Anal Hidradenoma Papilliferum

description: A benign neoplasm arising from the perianal sweat glands. It presents as a cystic nodular lesion and is characterized by the presence of cystic and papillary structures. The papillary structures contain connective tissue and are covered by two layers of epithelium.


Metastatic Low Grade Astrocytoma

description: Low grade astrocytoma that has spread from its primary site to another anatomic site.


name: Clonal Monocytosis of Undetermined Significance

description: A myelodysplastic/myeloproliferative neoplasm characterized by the presence of persistent monocytosis, presence of at least one myeloid neoplasm-associated mutation, absence of significant dysplasia or increased blasts in the bone marrow, absence of morphologic findings suggestive of chronic myelomonocytic leukemia in the bone marrow, and absence of history of a reactive condition that would explain the persistent monocytosis.


Recurrent Vulvar Carcinoma

description: The reemergence of vulvar carcinoma after a period of remission.


Malignant neoplasm of stomach stage IV

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 7th ed.)


name: Pathologic Stage 0 Merkel Cell Carcinoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: In situ primary tumor. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Hodgkin's disease lymphocyte depletion type recurrent

description: The reemergence of lymphocyte-depleted classic Hodgkin lymphoma after a period of remission.


Stage IB1 Cervical Cancer AJCC v9

description: Stage IB1 includes: T1b1, N0, M0. T1b1: Tumor measuring more than 5 mm in depth and equal or less than 2 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Gemistocytic Astrocytoma, IDH-Mutant

description: Gemistocytic astrocytoma carrying IDH mutations.


name: Pathologic Stage IV Merkel Cell Carcinoma AJCC v8

description: Stage IV includes: T0-4, Any N, M1. T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. M1: Distant metastasis microscopically confirmed. (AJCC 8th ed.)


Vaginal Papillary Carcinoma

description: A rare squamous cell carcinoma that arises from the vagina resembling transitional cell carcinoma of the urinary tract.


name: Refractory Fallopian Tube Transitional Cell Carcinoma

description: Fallopian tube transitional cell carcinoma that is resistant to treatment.


Esophageal Infection

description: An infectious process affecting the esophagus.


Localized Malignant Solid Neoplasm

description: A malignant solid neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Leukoplakia of anus

description: The presence of a painless whitish patch on the anal mucosa.  Histologic examination reveals hyperkeratosis and acanthosis.


Stage II Bladder Cancer AJCC v8

description: Stage II includes: (T2a, N0, M0); (T2b, N0, M0). T2a: Tumor invades superficial muscularis propria (inner half). T2b: Tumor invades deep muscularis propria (outer half). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Idiopathic Ketotic Hypoglycemia

description: Ketotic hypoglycemia that usually occurs in young, thin children in association with infection or fasting, and which typically resolves by age 6-8 years.


name: Stage IIIA Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of lymph node regions on both sides (above and below) of the diaphragm. This may be accompanied by extra-lymphatic extension in association with adjacent lymph node involvement (i.e., local extension from a lymph node area into a nearby organ) and/or involvement of spleen. No constitutional symptoms are recorded. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Tubular Neoplasm

description: A benign or malignant neoplasm characterized by the presence of a tubular architecture. This category includes tubular adenomas and tubular carcinomas.


name: Lacrimal Drainage System Exophytic Papilloma

description: A benign exophytic papillary neoplasm that arises from the lacrimal drainage system. It consists of fibrovascular cores lined by epithelial cells.


name: Abnormal Blood Chemistry and Hematology Test Result

description: A laboratory test result that indicates the presence of abnormal blood chemistry and/or hematology values.


name: Hodgkin's disease mixed cellularity stage I subdiaphragmatic


Anal infection

description: An infectious process affecting the anal area.


Reserve Cell Hyperplasia

description: Hyperplasia of the immature cells located between the surface columnar epithelium and the basal layer.


name: Hodgkin's Disease, Lymphocyte Depletion, Reticular

description: A lymphocyte depleted Hodgkin lymphoma characterized by the presence of reticular fibrosis.


name: Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

description: Limited stage Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Lacrimal Gland Acinic Cell Carcinoma

description: An extremely rare, low-grade, salivary gland-type carcinoma that arises from the lacrimal gland. It exhibits acinar differentiation.


Urethral Infection

description: A bacterial, viral, or fungal infectious process affecting the urethra.


Biliary Intraepithelial Neoplasia-2

description: Biliary intraepithelial neoplasia characterized by the presence of moderate epithelial atypia.


Recurrent Malignant Brain Neoplasm

description: The reemergence of a malignant brain neoplasm after a period of remission.


Abdominal Rhabdomyosarcoma

description: Rhabdomyosarcoma involving the organs and structures in the abdomen.


Injection site thrombophlebitis

description: Thrombophlebitis in the veins surrounding an injection site.


name: Refractory Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive

description: Accelerated phase chronic myeloid leukemia, BCR-ABL1 positive that is resistant to treatment.


Rare Diseases

description: A non-neoplastic or neoplastic disorder that is uncommon.


name: Microvascular Thrombosis Related to COVID-19

description: Blood clot formation in the small blood vessels of the body in a patient with probable or confirmed acute COVID-19.


name: Ann Arbor Stage II Lymphocyte-Depleted Classic Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Prosthetic Valve Thrombosis

description: The formation of a blood clot that is attached to or near an artificial heart valve; this can cause dysfunction of the valve, and possibly lead to an embolic event should the thrombus become dislodged.


Vulvar Dysplastic Melanocytic Nevus

description: A rare, elevated and pigmented, compound or junctional nevus that arises from the vulva. It affects women in their reproductive years and may be associated with the presence of dysplastic nevi in other anatomic areas. It is characterized by the presence of epithelioid or spindle-shaped melanocytes exhibiting nuclear pleomorphism and prominent nucleoli.


name: Borderline Ovarian Serous Papillary Cystic Tumor

description: A neoplasm of low malignant potential arising from the ovary. It is characterized by the presence of papillary proliferations of atypical serous epithelial cells and a cystic component.  There is no evidence of stromal invasion.


Unresectable Malignant Gastric Neoplasm

description: A malignant gastric neoplasm that is not amenable to surgical resection.


name: Invasive Bladder Urothelial Carcinoma with Trophoblastic Differentiation

description: An invasive bladder urothelial carcinoma characterized by the presence of trophoblastic differentiation.


Metastatic NUT Carcinoma

description: NUT carcinoma that has spread from its original site of growth to another anatomic site.


Peritoneal Sarcomatosis

description: A condition in which a sarcoma has spread extensively throughout the peritoneum.


Dehiscence

description: A splitting open of an anatomical structure, zone, or organ with the exposure or discharge of its content.


Infective cystitis

description: An infectious process affecting the urinary bladder.


Diffuse Midline Glioma, H3 K27-Altered

description: A diffuse midline glioma characterized by H3 K27 alteration and usually either a histone H3 K27M mutation, an EGFR mutation, or aberrant overexpression of EZHIP. The prognosis is poor.


Refractory WHO Grade 2 Glioma

description: WHO grade 2 glioma that is resistant to treatment.


name: Metastatic Bladder Plasmacytoid Urothelial Carcinoma

description: Bladder plasmacytoid urothelial carcinoma that has spread to another anatomic site.


name: IgM Monoclonal Gammopathy of Undetermined Significance, Plasma Cell Type

description: A subtype of IgM monoclonal gammopathy of undetermined significance characterized by the presence of clonal plasma cells, absence of clonal B-lymphocytes, and absence of MYD88 gene mutation. The t(11;14)(q13;q32) is present in some cases. This subtype is considered a precursor of multiple myeloma.


name: Unresectable Digestive System Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from any part of the digestive system and is not amenable to surgical resection.


Non-Neoplastic Mediastinal Disorder

description: A non-neoplastic disorder that affects the structures of the mediastinum.  Representative examples include mediastinitis and thymic hyperplasia.


Cytomegalovirus gastroenteritis

description: Gastroenteritis resulting from an infection with cytomegalovirus.


Childhood Digestive System Neoplasm

description: A neoplasm that affects any part of the digestive system and occurs during childhood.


Mixed Trophoblastic Tumor

description: A gestational trophoblastic tumor characterized by the presence of two or three histological types of gestational trophoblastic tumor, including choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor.


Stage 0 Gallbladder Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Neuropathy, Recurrent, with Pressure Palsies

description: An autosomal dominant condition caused by mutation(s) in the PMP22 gene, encoding peripheral myelin protein 22. Neuropathy is precipitated by mechanical compression on a nerve, typically with onset in the first and second decades.


Stage III Merkel Cell Carcinoma AJCC v7

description: Stage III includes: IIIA: (Any T, N1a, M0) and IIIB: (Any T, N1b/N2, M0).  N1a: Micrometastasis in regional lymph nodes.  N1b: Macrometastasis in regional lymph nodes.  N2: In transit metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Stage IIA Gallbladder Cancer AJCC v8

description: Stage IIA includes: T2a, N0, M0. T2a: Tumor invading the perimuscular connective tissue on the peritoneal side, without involvement of the serosa (visceral peritoneum). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Fibrohistiocytic Neoplasm

description: A benign, intermediate, or malignant mesenchymal neoplasm composed of fibrohistiocytic cells, spindle fibroblastic cells, and histiocytes, in a storiform pattern.


Stage IIB Cervical Cancer AJCC v9

description: Stage IIB includes: T2b, N0, M0. T2b: Tumor with parametrial invasion but not up to the pelvic wall. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Unresectable Sarcoma

description: A sarcoma which is not amenable to surgical resection.


name: Stage II Gestational Trophoblastic Neoplasm AJCC v8

description: Stage II includes: T2, M0. T2: Gestational trophoblastic neoplasm in which the tumor extends to other genital structures (ovary, tube, vagina, broad ligaments) by metastasis or direct extension. M0: No distant metastasis. (AJCC 8th Ed.)


name: Smoldering Systemic Mastocytosis with an Associated Myeloid Neoplasm

description: Smoldering systemic mastocytosis associated with the presence of a clonal non-mast cell myeloid neoplasm (e.g., myelodysplastic syndrome,  myeloproliferative neoplasm, and acute myeloid leukemia).


name: Human papillomavirus negative squamous cell carcinoma

description: A squamous cell carcinoma not associated with human papilloma virus infection.


Stage II Cervical Cancer AJCC v6

description: Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIB (T2b, N0, M0). T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion. T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Recurrent Anal Mucinous Adenocarcinoma

description: The reemergence of anal mucinous adenocarcinoma after a period of remission.


Prostate Cancer by AJCC v7 Stage

description: A term that refers to the staging of prostate carcinoma according to the American Joint Committee on Cancer, 7th edition.


PALB2-Associated Malignant Neoplasm

description: A malignant neoplasm caused by deleterious germline mutation in the PALB2 gene. This mutation is associated with the development of breast carcinoma and pancreatic carcinoma.


Liver Neuroendocrine Tumor G1

description: A well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the liver. The mitotic count is less than 2 per 10 HPF.


Rare Malignant Solid Neoplasm

description: A malignant solid neoplasm with an annual incidence of less than 6 per 100,000 people.


name: Pancreatic Moderately Differentiated Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma characterized by the presence of medium-sized duct-like structures and small malignant tubular glandular structures.


name: Steroid-Dependent Gastrointestinal Tract Acute Graft Versus Host Disease

description: Gastrointestinal tract acute graft versus host disease that is responsive to treatment with steroids but relapses during attempts at tapering or discontinuing steroid therapy.


Surfactant Protein D Deficiency

description: Deficiency of surfactant protein D. When present in normal amounts, this protein offers protection against pulmonary infection and inflammation.


Esophageal Cancer by AJCC v7 Stage

description: A term that refers to the staging of esophageal carcinoma according to the American Joint Committee on Cancer, 7th edition.


Type I Endometrial Adenocarcinoma

description: A classification of primary endometrial adenocarcinomas that refers to endometrioid adenocarcinoma and mucinous adenocarcinoma.


Stage 0 Vulvar Cancer AJCC v6

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (preinvasive carcinoma. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Low Grade Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth.


name: Hemolytic disease of fetus OR newborn due to ABO immunization

description: A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of anti-A or anti-B antibodies from a mother to the child via the placenta against A or B antigens of the newborn's blood.


name: Prostate Carcinoma Metastatic in the Soft Tissue

description: A carcinoma that arises from the prostate gland and has spread to the soft tissues.


name: Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC v8

description: Stage IIIA includes: T0-2, N1, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Metastatic malignant neoplasm to viscera

description: A malignant neoplasm which has spread from its original site of growth to any visceral site.


name: Cytogenetically normal acute myeloid leukemia

description: Acute myeloid leukemia not associated with cytogenetic abnormalities.


Adenocarcinoma in tubulovillous adenoma

description: A non-invasive or invasive adenocarcinoma arising from a tubulovillous adenoma.


Breast Solid Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the breast.  It is characterized by the presence of cellular solid nests and trabeculae that contain spindle-shaped, plasmacytoid, and large neuroendocrine cells.


Food Poisoning

description: Any disorder that results from the consumption of food contaminated with an infectious agent or toxin.


Primary Meningeal Melanocytic Neoplasm

description: A melanocytic neoplasm that arises from the leptomeninges. This category includes diffuse proliferative processes (melanocytosis and melanomatosis) and circumscribed processes (melanocytoma and melanoma).


name: Lugano Classification Stage IV Hodgkin Lymphoma AJCC v8

description: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or noncontiguous extralymphatic organ involvement in conjunction with nodal stage II disease; or any extralymphatic organ involvement in nodal stage III disease. Stage IV includes any involvement of the CSF, bone marrow, liver, or lungs (other than by direct extension in stage IIE disease). (from AJCC 8th Ed.)


Gastric infection

description: An acute or chronic infectious process affecting the stomach.


Anal Inflammatory Cloacogenic Polyp

description: A non-neoplastic polypoid lesion that arises from the anal transitional zone.  It is characterized by the presence of hyperplastic rectal mucosa that is partially covered by squamous or transitional epithelium.


name: Peritoneal and retroperitoneal disorders

description: A non-neoplastic or neoplastic disorder that affects the peritoneum and/or retroperitoneum.


Stage IIB Cervical Cancer AJCC v8

description: Stage IIB includes: T2b, Any N, M0. T2b: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina with parametrial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


Single Ventricle Defect

description: A diverse group of congenital cardiovascular abnormalities that share one characteristic, the presence of a single functional cardiac ventricle.


name: Non-Neoplastic Digestive System Disorder

description: A non-neoplastic disorder that affects the gastrointestinal tract, anus, liver, biliary system, and pancreas. Representative examples include infections, ulcers, cirrhosis, and diverticulosis.


Second Primary Tumor

description: A new primary neoplasm that occurs in a person who was previously diagnosed with another primary neoplasm.


name: Infiltrating Ureter Urothelial Carcinoma with Mixed Differentiation


Metastatic non-small cell carcinoma

description: Non-small cell carcinoma that has spread from its original site of growth to another anatomic site.


Malignant Visual Pathway Neoplasm

description: A primary or metastatic malignant neoplasm that affects the visual pathway.


Metastatic Ampulla of Vater Carcinoma

description: Carcinoma that arises from the ampulla of Vater and has spread to another anatomic site.


Sternotomy Scar

description: Replacement of destroyed tissue by fibrous tissue due to a surgical procedure where a vertical inline incision is made along the sternum, after which the sternum itself is divided. (ACC/AHA)


name: Refractory Histiocytic and Dendritic Cell Neoplasm

description: A histiocytic and dendritic cell neoplasm that does not respond to treatment.


Stage IIC Merkel Cell Carcinoma AJCC v7

description: Stage IIC includes: T4, N0, M0.  T4: Primary tumor invades bone, muscle, fascia, or cartilage.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Nail Matrix Nevus

description: An acral nevus that arises from the nail matrix.


Myeloid Neoplasm with Mutated TP53

description: Myeloid neoplasm characterized by the presence of TP53 gene mutations. This category includes myelodysplastic syndrome, myelodysplastic syndrome/acute myeloid leukemia, and acute myeloid leukemia with mutated TP53.


name: Lugano Classification Stage II Childhood Hodgkin Lymphoma AJCC v8

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Cutaneous Juvenile Xanthogranuloma

description: A benign histiocytic tumor that arises from the skin and occurs during childhood; it is distinct from Langerhans cell histiocytosis. It is characterized by the presence of lipid-laden, foamy histiocytes and Touton-type giant cells in the dermis. The lesions usually develop during infancy. They consist of cutaneous papules and nodules (most often in the head and neck).


name: Pathologic Stage IVA Esophageal Adenocarcinoma AJCC v8

description: Stage IVA includes: (T4a, N2, M0, Any G); (T4b, N0-2, M0, Any G); (Any T, N3, M0, Any G). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Epilepsy congenital

description: A seizure disorder that is present at the time of birth.


name: Stage IIIA Cervical Cancer AJCC v6 and v7

description: Stage IIIA includes: T3a, N0, M0.  T3a: Tumor involves lower third of vagina, no extension to pelvic wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Appendix Tubulovillous Adenoma

description: An adenoma arising from the appendix.  It is characterized by the presence of tubular and villous epithelial structures and it is associated with dysplasia.


Favorable Hodgkin Lymphoma

description: A Hodgkin lymphoma with favorable prognosis.


Unspecified dermatitis due to sun

description: Inflammation of the skin resulting from exposure to the sun.


Stage III Testicular Cancer AJCC v8

description: Stage III includes: Any pT/TX, Any N, M1, SX. TX: Testicular cancer in which the primary tumor cannot be assessed. M1: Testicular cancer with distant metastasis. SX: Marker studies not available or not performed. (AJCC 8th ed.)


Benign Musculoskeletal Neoplasm

description: A mesenchymal neoplasm that arises from muscle or bone and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Acute Myeloid Leukemia with t(5;17)(q35;q21); NPM1-RARA

description: Acute myeloid leukemia with the variant RARA t(5;17)(q35;q21) and the expression of NPM1-RARA fusion protein.


name: Vaginal intraepithelial neoplasia grade 1

description: Vaginal intraepithelial neoplasia characterized by the presence of koilocytosis and disorganization and thickening of the basal layer.


name: Localized Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that is restricted to the site of origin without evidence of metastasis.


Fine motor delay

description: Delayed acquisition of age appropriate motor milestones that produce small and precise movements.


name: Recurrent Malignant Endocervical Neoplasm

description: The reemergence of a malignant neoplasm of the endocervix after a period of remission.


name: Stage IA Gestational Trophoblastic Tumor AJCC v7

description: Stage IA includes: T1, M0, Risk factors: low risk.  T1: Tumor confined to uterus.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Sclerodermatous Graft Versus Host Disease

description: A rare form of chronic graft-versus-host disease characterized by cutaneous features and/or mucocutaneous features including sclerosis, atrophy, and contractures. It may manifest as localized or generalized disease.


Chronic Myelomonocytic Leukemia-1

description: A chronic myelomonocytic leukemia characterized by the presence of less than 10 percent blasts in the bone marrow and less than 5 percent blasts in the peripheral blood.


name: Stage 0 Gallbladder Cancer AJCC v6 and v7

description: Stage 0 includes: (Tis, N0, M0).  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


Differentiated Granulocytic Sarcoma

description: A granulocytic sarcoma composed of promyelocytes and more mature neutrophils (WHO 2001).


name: Malignant mesothelioma of tunica vaginalis

description: A rare malignant mesothelioma that arises from the tunica vaginalis.


Celosomy

description: A developmental abnormality characterized by the complex protrusion of viscera outside the abdominal wall.


Phobia, School

description: An overwhelming, irrational, and persistent fear of attending school.


name: squamous cell carcinoma of urinary tract

description: A rare squamous cell carcinoma that arises from the urinary tract. Almost all cases have been reported in the bladder. Causes include urinary stasis, recurrent chronic inflammation, and smoking. In regions where schistosomiasis is endemic, it is the major etiologic factor of bladder squamous cell carcinoma.


Diffuse Mixed-Cell Lymphoma

description: An antiquated term referring to non-Hodgkin lymphomas with a mixed cellular composition. This term applies to both B- and T- cell non-Hodgkin lymphomas.


name: Recurrent Cervical Squamous Cell Carcinoma

description: The reemergence of cervical squamous cell carcinoma after a period of remission.


name: Intrahepatic Bile Duct Microcystic Adenoma

description: An adenoma that arises from the intrahepatic bile ducts and it is characterized by the presence of microcystic changes.


Refractory WHO Grade 3 Glioma

description: A WHO grade 3 glioma that is resistant to treatment.


Non-Hematologic Malignancy

description: A malignant neoplasm that arises from a site other than the bone marrow and lymphoid tissue.


name: Metastatic Micropapillary Urothelial Carcinoma

description: Micropapillary urothelial carcinoma that has spread to another anatomic site.


Brain Diseases, Metabolic

description: A group of neurologic disorders caused by alterations to the biochemical functioning of the brain. They are characterized by an altered level of consciousness and depressed cerebral functioning.


name: Pathologic Stage II Cutaneous Melanoma AJCC v8

description: Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Stage IC Fallopian Tube Cancer AJCC v8

description: Stage IC includes: T1c, N0, M0. T1c: Fallopian tube cancer with tumor limited to fallopian tubes, with any of the following: surgical spill, capsule ruptured before surgery or tumor on fallopian tube surface, or malignant cells in ascites or peritoneal washings. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Metastatic gastric adenocarcinoma

description: A gastric adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Endometrial Endometrioid Adenocarcinoma with Small Glands, Tubules or Cords


Unresectable Vulvar Carcinoma

description: Vulvar carcinoma that is not amenable to surgical resection.


Stage I Gastric Cancer AJCC v6

description: Stage I includes: IA: (T1, N0, M0) and IB: (T1, N1, M0); (Ta/b, N0, M0).  T1: Tumor invades lamina propria or submucosa.  T2: Tumor invades the muscularis propria or the subserosa.  T2a: Tumor invades muscularis propria. T2b: Tumor invades subserosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1 to 6 regional lymph nodes.  N2: Metastasis in 7 to 15 regional lymph nodes.  M0: No distant metastasis. (AJCC 6th ed.)


name: Stage I Ampulla of Vater Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor measuring 1 cm or less and is confined within the sphincter of Oddi. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Neuronevus

description: An intradermal nevus characterized by the presence of nests of atrophic nevus cells which are hyalinized and resemble nerve bundles.


MGMT-Unmethylated Glioblastoma

description: A glioblastoma characterized by the absence of DNA methylation in the promoter region of the MGMT gene. It is associated with a poor outcome.


Shunt thrombosis

description: The presence of a thrombus within a vascular shunt.


name: Benign Peritoneal and Retroperitoneal Neoplasm

description: A neoplasm that arises from the peritoneum and/or retroperitoneum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Metastatic Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that has metastasized from its original site of growth to another anatomic site.


name: Localized Childhood Astrocytoma by Toronto Guidelines v2

description: Localized disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage IIIA Bladder Cancer AJCC v8

description: Stage IIIA includes: (T3a, T3b, T4a, N0, M0); (T1-T4a, N1, M0). T1: Tumor invades lamina propria (subepithelial connective tissue). T2: Tumor invades muscularis propria. T3: Tumor invades perivesical soft tissue. T3a: Tumor invades perivesical soft tissue, microscopically. T3b: Tumor invades perivesical soft tissue, macroscopically (extravesical mass). T4a: Extravesical tumor invades directly into prostatic stroma, uterus, vagina. N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node). M0: No distant metastasis. (AJCC 8th ed.)


name: Agoraphobia without history of panic disorder

description: An anxiety disorder characterized by agoraphobia in the absence of a history of panic attacks; the individual fears incapacitation or humiliation in open, public places or situations due to panic-like symptoms rather than a full-blown panic attack.


name: Stage II Childhood Retinoblastoma by Toronto Guidelines v2

description: Enucleation with microscopic residual disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Esophageal Glandular Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities involve either the lower or both the lower and the upper half of the esophageal glandular epithelium.


Cervical Yolk Sac Tumor

description: A yolk sac tumor that arises from the cervix. Patients present with abnormal vaginal bleeding and a polypoid, friable mass, protruding into the vagina.


Enterovesical Fistula

description: An abnormal communication between the urinary bladder and the intestine.


Verruca Palmaris

description: A wart on the palmar surface of the hand. It is caused by human papillomavirus.


name: Pathologic Stage II Retinoblastoma AJCC v8

description: Stage II includes: pT4, pN0, cM0, Any H. pT4: Evidence of extraocular tumor: tumor at the transected end of the optic nerve, tumor in the meningeal spaces around the optic nerve, full-thickness invasion of the sclera with invasion of the episclera, adjacent adipose tissue, extraocular muscle, bone, conjunctiva, or eyelids. pN0: No lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Recurrent Urethral Cancer

description: The reemergence of urethral carcinoma after a period of remission


name: Developmental and Epileptic Encephalopathy 44

description: An autosomal recessive subtype of developmental and epileptic encephalopathy caused by mutation(s) in the UBA5 gene, encoding ubiquitin-like modifier-activating enzyme 5.


Neuroendocrine carcinoma, metastatic

description: A neuroendocrine carcinoma that has spread from its original site of growth to another anatomic site.


Mental disorder in childhood

description: A category of psychiatric disorders which includes disorders most commonly identified in infancy, childhood, or adolescence.


name: Myelodysplastic Syndrome, Unclassifiable, with Single Lineage Dysplasia

description: Myelodysplastic syndrome, unclassifiable characterized by unilineage dysplasia and associated pancytopenia.


Stage I Urethral Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: For male penile urethra and female urethra: Tumor invades subepithelial connective tissue. For prostatic urethra: Tumor invades urethral subepithelial connective tissue immediately underlying the urothelium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: malignant neoplasm of lacrimal apparatus

description: A primary or metastatic malignant neoplasm affecting the lacrimal gland or the lacrimal drainage system.


Recurrent Tectal Glioma

description: The reemergence of tectal glioma after a period of remission.


name: Supratentorial Ependymoma, Not Elsewhere Classified

description: A circumscribed ependymoma that arises from the supratentorial region of the brain, characterized by the absence of a fusion gene involving ZFTA or YAP1 genes.


Ossification of the Ligamentum Flavum

description: A condition in which the ligamentum flavum is progressively ossified which may cause compression of elements inside the spinal canal, resulting in various neurological symptoms.


name: Secondary Supratentorial Anaplastic Astrocytoma

description: An anaplastic astrocytoma occurring in the supratentorial area secondary to a preexisting tumor.


neoplasm of corpus callosum

description: A benign or malignant neoplasm that affects the corpus callosum.


name: Steroid Refractory Graft Versus Host Disease

description: Graft versus host disease that does not respond to steroid treatment.


name: Lugano Classification Stage II Adult Hodgkin Lymphoma AJCC v8

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Desmoplastic trichoepithelioma

description: A benign adnexal tumor occurring in the face of young female subjects. It is characterized by the presence of epithelial neoplastic cells and keratinous cysts in a desmoplastic stroma.


name: Ampulla of Vater Large Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region.  It is characterized by the presence of malignant large cells.


Locally Advanced Melanoma

description: Melanoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Hereditary Paraganglioma

description: A hereditary neoplasm arising from paraganglia. The majority of cases (up to 80%) are multifocal. It is caused by mutations in SDHA, SDHB, SDHC, SDHD, and SDHAF2 genes.


Malignant Intracranial Germ Cell Tumor

description: A malignant germ cell tumor that affects the structures within the cranium.


Secondary Plasma Cell Leukemia

description: Transformation of plasma cell myeloma to plasma cell leukemia.


name: Invasive Bladder Urothelial Carcinoma Associated with Urethral Carcinoma

description: Invasive urothelial carcinoma of the bladder which is associated with the presence of in situ or infiltrating urethral carcinoma.


name: Borderline Paratesticular Mucinous Tumor

description: A rare, non-invasive, mucinous cystic tumor that arises from the paratesticular structures. It is characterized by the presence of irregular papillary formations with irregular branching. The papillae are lined by atypical mucinous epithelial cells. Metastases have not been reported.


name: Acute Myocardial Injury with Heart Failure Related to COVID-19

description: Acute myocardial injury with evidence of new or worsening signs and symptoms of heart failure in a patient with probable or confirmed acute COVID-19.


name: Recurrent Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: The reemergence of extrapulmonary large cell neuroendocrine carcinoma after a period of remission.


Flexural Skin Nevus

description: A benign nevus occurring in the flexural skin.


name: FIGO Grade 2 Endometrial Mucinous Adenocarcinoma

description: A primary mucinous adenocarcinoma of the endometrium that contains 6-50% non-squamous solid areas.


Malignant mastocytosis

description: A group of malignant mast cell disorders including aggressive systemic mastocytosis, mast cell leukemia, mast cell sarcoma, and systemic mastocytosis with an associated myeloid neoplasm. Individuals with advanced systemic mastocytosis have a reduced life expectancy, with median survival measured in months to years.


Acute Placental Infarction

description: A focus of necrotic placental parenchyma with clearly visible outlines of necrotic villous structures and absence of any hyalinization and fibrosis, which is frequently 1-2 days of duration.


name: Recurrent Vaginal Squamous Cell Carcinoma

description: The reemergence of vaginal squamous cell carcinoma after a period of remission.


High Grade Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma exhibiting more than 50% solid non-glandular, non-squamous growth.


name: Cerebellar Glioneuronal and Neuronal Tumors

description: Glioneuronal and neuronal tumors occurring in the cerebellum.


name: Temporal Lobe Pleomorphic Xanthoastrocytoma

description: A pleomorphic xanthoastrocytoma that arises from the temporal lobe of the brain.


name: Refractory Fallopian Tube Endometrioid Adenocarcinoma

description: Fallopian tube endometrioid adenocarcinoma that is resistant to treatment.


name: Intermediate Osteoclastic Giant Cell-Rich Tumor of Bone

description: A benign but locally aggressive giant cell tumor that arises from the bone.


Stage IB Esophageal Cancer AJCC v7

description: Stage IB includes: For squamous cell carcinoma: (T1, N0, M0, G2-3, Tumor location: Any); (T2-3, N0, M0, G1, GX, Tumor location: Lower, X). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated.  G3: Poorly differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Stage IV Esophageal Cancer AJCC v7

description: Stage IV includes: For squamous cell carcinoma: Any T, Any N, M1, Any G, Tumor location: Any.  For adenocarcinoma: Any T, Any N, M1, Any G. M1: Distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Tracheal Verrucous Carcinoma

description: An exophytic, warty, well differentiated, slow growing and non-metastasizing squamous cell carcinoma arising from the trachea.


name: Childhood Ependymoma by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood ependymoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


name: Sleep Disorder due to General Medical Condition

description: A sleep disorder (insomnia, hypersomnia, or parasomnia) for which there is strong physiological evidence that the disorder is etiologically linked to a general medical condition.


name: Other Genetic Syndrome Associated with Congenital Heart Defect

description: An indication that the patient has a history of a genetic syndrome associated with a congenital heart defect other than those listed.


Advanced Uterine Corpus Cancer

description: Uterine corpus cancer that has spread extensively to other anatomic sites or is no longer responding to treatment.


Localized Pancreatic Adenocarcinoma

description: An adenocarcinoma that arises from the pancreas and has not spread to other anatomic sites.


Recurrent Malignant Lymphoid Neoplasm

description: The reemergence of a malignant lymphoid neoplasm after a period of remission.


name: Langerhans Cell Histiocytosis, Disseminated

description: Langerhans cell histiocytosis presenting with disseminated disease.


Cutaneous Melanoma of the Extremity

description: A cutaneous melanoma that arises from the upper or lower extremity.


Surfactant Protein Deficiency

description: A congenital deficiency of one of the surfactant proteins.


name: acute diastolic congestive heart failure

description: Acute congestive heart failure due to a left ventricle which does not fill properly due to decreased compliance though the ejection fraction may be preserved.


name: Myelodysplastic Syndrome, Unclassifiable, with 1 Percent Blasts

description: Myelodysplastic syndrome, unclassifiable characterized by refractory cytopenia with unilineage dysplasia or refractory cytopenia with multilineage dysplasia but with 1 percent blasts in the peripheral blood.


Device related infection

description: An infectious disorder caused by the use of a medical device.


name: Fallopian Tube High Grade Serous Adenocarcinoma

description: A rapidly growing serous adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of high grade cytologic features and frequent mitotic figures.


Medullary carcinoma

description: A term referring to medullary carcinomas which can develop in various anatomic sites such as the thyroid gland, breast, colon, rectum, and small intestine.


Refractory Basal Cell Carcinoma

description: Basal cell carcinoma that is resistant to treatment.


name: Childhood Malignant Nervous System Neoplasm

description: A primary or metastatic malignant neoplasm that affects the nervous system and occurs during childhood.


Adrenocortical hyperplasia

description: Congenital or acquired hyperplasia of the cells of the adrenal cortex.


Vaginal abscess

description: An abscess that is located in the vagina.


Malignant tumor of optic nerve

description: A primary or metastatic malignant neoplasm that affects the optic nerve.


Bacillary Peliosis

description: An infection that is caused by Bartonella henselae, which occurs primarily in immunocompromised persons; it is characterized by blood-filled cysts in the liver and spleen.


name: Multifocal nodular oncocytic hyperplasia of salivary gland

description: A rare lesion characterized by multiple non-neoplastic nodular proliferations composed of cells with abundant granular eosinophilic cytoplasm (oncocytes) and/or clear cytoplasm (clear cells) in one or both parotid glands. (WHO 2017)


Stage IIB Bone Cancer AJCC v7

description: Stage IIB includes: T2, N0, M0, G3, G4.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Placental Malformation

description: A non-neoplastic abnormality that affects the placenta. Representative examples include multi-lobed and bilobed placenta.


Childhood Infectious Disorder

description: An infectious disorder that occurs in childhood.


name: Acute gonococcal infection, of upper genitourinary tract

description: A gonococcal infection of the upper urinary tract that is rapid in onset.


Lipidized Glioblastoma

description: A rare glioblastoma characterized by the presence of a predominant population of neoplastic cells with foamy cytoplasm.


Maternal Sepsis

description: A pathologic response to infection in a mother or pregnant woman.


name: Lugano Classification Advanced Stage Childhood Hodgkin Lymphoma AJCC v8

description: Advanced stage childhood Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


name: Stage IV Esophageal Adenocarcinoma AJCC v7

description: Stage IV includes: Any T, Any N, M1, Any G.  M1: Distant metastasis.  (AJCC 7th ed.)


name: Endometrial Mucinous Adenocarcinoma, Gastric-Type

description: A rare mucinous adenocarcinoma arising from gastric metaplasia of the endometrium.


Adult Anaplastic (Malignant) Meningioma

description: An anaplastic (malignant) meningioma occurring in adults.


Neonatal Listeriosis

description: A bacterial infection by Listeria monocytogenes in a newborn infant up to 28 days old.


name: Serous papillary cystic tumor of borderline malignancy

description: A low malignant potential cystic serous epithelial neoplasm arising from the ovary. Cases with identical morphology have been described arising from the peritoneum as well. It is characterized by an atypical epithelial proliferation and a papillary growth pattern. There is no evidence of destructive stromal invasion.


name: Stage I Appendix Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor measuring 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Executive dysfunction

description: Cognitive, emotional, and behavioral difficulties that often occur in conjunction with frontal lobe disorders, including traumatic injury and dementia. It is also a feature of attention deficit disorder and other non-trauma-induced conditions.


Virus-Related Malignant Neoplasm

description: A malignancy in which there is a well-documented association between a neoplastic process and a specific virus as the causative agent.


name: Oligometastatic Pancreatic Ductal Adenocarcinoma

description: Pancreatic ductal adenocarcinoma that has metastasized to a limited number of sites.


Postpartum Obstetric Air Embolism

description: Presence of a large air bubble in the maternal vascular system which originated from a distant site during the postpartum period.


Bone Cancer by AJCC v7 Stage

description: A term that refers to the staging of bone cancer, following the rules of the TNM AJCC v7 classification system.


Non-Neoplastic Heart Disorder

description: A non-neoplastic disorder that affects the heart and/or the pericardium.  Representative examples include congestive heart disease, endocarditis, and constrictive pericarditis.


Stage IB1 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 5 mm in depth and equal or less than 4 cm in maximum diameter. (FIGO 2009)


name: Precursor T-lymphoblastic lymphoma/leukemia stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Low Grade Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic process characterized by the presence of mild dysplastic cytological changes which are usually present in the lower part of the squamous epithelium.  Representative examples include the low grade esophageal squamous intraepithelial neoplasia, low grade cervical squamous intraepithelial neoplasia, low grade vaginal intraepithelial neoplasia, and low grade vulvar intraepithelial neoplasia.


name: intestinal type adenocarcinoma of gallbladder

description: An adenocarcinoma that arises from the gallbladder.  It is characterized by the presence of neoplastic tubular glands lined by columnar cells or neoplastic glands lined by goblet cells.


Disorder of Androgen Synthesis

description: An enzyme deficiency in the androgen biosynthesis pathway, resulting in the underproduction of one or more androgens by the adrenal glands and/or gonads.