name: DNA replication licensing factor MCM2, initiator methionine removed form (human)

description: A DNA replication licensing factor MCM2, initiator methionine removed form in human. UniProtKB:P49736, 2-904.


name: DNA replication licensing factor MCM2 phosphorylated 1 (human)

description: A DNA replication licensing factor MCM2 (human) that has been phosphorylated at Ser-108. UniProtKB:P49736, Ser-108, MOD:00046.


name: DNA replication licensing factor MCM2 isoform 1 (Arabidopsis thaliana)

description: A DNA replication licensing factor MCM2 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9LPD9-1.


name: DNA replication licensing factor MCM2 isoform 1 (human)

description: A DNA replication licensing factor MCM2 isoform 1 that is encoded in the genome of human.


name: DNA replication licensing factor MCM2 isoform 1

description: A DNA replication licensing factor MCM2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49736-1 or a 1:1 ortholog thereof.


name: DNA replication licensing factor MCM2 cysteinylated 1 (human)

description: A DNA replication licensing factor MCM2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-584 of the amino acid sequence represented by UniProtKB:P49736. UniProtKB:P49736, Cys-584, MOD:00765.


name: E3 ubiquitin-protein ligase NLA isoform 1 (Arabidopsis thaliana)

description: An E3 ubiquitin-protein ligase NLA (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9SRX9-1.


name: SL30A_ARATH Serine/arginine-rich SC35-like splicing factor SCL30A (sprot)

description: A protein that is a translation product of the SCL30A gene in Arabidopsis thaliana.


name: serine/arginine-rich SC35-like splicing factor SCL30A isoform 1 (Arabidopsis thaliana)

description: A serine/arginine-rich SC35-like splicing factor SCL30A (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9LHP2-1.


name: uncharacterized protein, LOC431649 translation product (chicken)

description: A laeverin that is encoded in the genome of chicken.


propionyl-CoA metabolic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways involving propionyl-CoA.


propionyl-CoA biosynthetic process

description: The chemical reactions and pathways resulting in the formation of propionyl-CoA.


propionyl-CoA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of propionyl-CoA.


name: large ribosomal subunit protein mL38 isoform h2 (human)

description: A large ribosomal subunit protein mL38 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96DV4-2.


name: positive regulation of violaceol I biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of violaceol I biosynthetic process.


name: lysosomal protective protein deaminated 2 (human)

description: A lysosomal protective protein (human) that has been deaminated on the residue at the position equivalent to Gln-380 of the amino acid sequence represented by UniProtKB:P10619-1. Example: UniProtKB:P10619-1, Gln-380, MOD:00685.


sestrin-3 isoform 1 (human)

A sestrin-3 isoform 1 that is encoded in the genome of human.


sestrin-3 isoform 1

A sestrin-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P58005-1 or a 1:1 ortholog thereof.


sestrin-3 isoform 1 (mouse)

A sestrin-3 isoform 1 that is encoded in the genome of mouse.


name: glucocorticoid receptor isoform hAlpha-D3 (human)

description: A glucocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04150-16.


name: C4BPB_RAT C4b-binding protein beta chain (sprot)

description: A C4b-binding protein beta chain that is encoded in the genome of rat.


name: DDB1- and CUL4-associated factor 4 isoform h2 (human)

description: A DDB1- and CUL4-associated factor 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WV16-2.


ovarian solid teratoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A mature teratoma that arises from the ovary and presents as a large solid mass. It contains multiple cysts that vary in size. Small foci of hemorrhage are also present.


familial temporal lobe epilepsy 4

description: A temporal lobe epilepsy characterized by autosomal dominant inheritance of occipitotemporal lobe epilepsy and migraine with visual aura and that has material basis in variation in the chromosome region 9q21-q22.


name: PROP1_HUMAN Homeobox protein prophet of Pit-1 (sprot)

description: A homeobox protein prophet of Pit-1 that is encoded in the genome of human.


name: FMDA_SCHPO Putative formamidase C869.04 (sprot)

description: A protein that is a translation product of the SPAC869.04 gene in Schizosaccharomyces pombe 972h-.


name: HAT1_SCHPO Histone acetyltransferase type B catalytic subunit (sprot)

description: A histone acetyltransferase type B catalytic subunit that is encoded in the genome of Schizosaccharomyces pombe 972h-.


A methyl glycoside that is beta-D-Gal-(1->4)-[beta-D-Gal-(1->4)-beta-D-Glc-(1->6)]-beta-D-GlcNAc in which the hydroxy group at position 6 of the galactose residue linked to O-4 of the reducing end glucosyl residue is replaced by an ammoniumyl group and the hydroxy group at the reducing-end anomeric centre is methylated.


alpha-enolase isoform 1 (mouse)

An alpha-enolase isoform 1 that is encoded in the genome of mouse.


O-acetyl-D-homoserine

The O-acetyl derivative of D-homoserine.


name: beta-secretase 2 proteolytic cleavage product

description: A beta-secretase 2 that has been processed by proteolytic cleavage.


name: DPH5_MOUSE Diphthine methyl ester synthase (sprot)

description: A diphthine methyl ester synthase that is encoded in the genome of mouse.


name: BORC5_MOUSE BLOC-1-related complex subunit 5 (sprot)

description: A BLOC-1-related complex subunit 5 that is encoded in the genome of mouse.


N-acetylglycyl residue

An N-acyl-alpha-aminoacyl group derived from N-acetylglycine


name: integral membrane protein 2B deaminated 1 (human)

description: An integral membrane protein 2B (human) that has been deaminated on the residue at the position equivalent to Asn-211 of the amino acid sequence represented by UniProtKB:Q9Y287-1. Example: UniProtKB:Q9Y287-1, Asn-211, MOD:00684.


name: histone H2B type 1-C/E/F/G/I, initiator methionine removed N6-acetyllysine form (human)

description: A histone H2B type 1-C/E/F/G/I (human) that has had the initiator methionine removed and that includes at least 1 N6-acetyllysine. UniProtKB:P62807, 2-126, MOD:00064.


Locally Advanced Endometrial Carcinoma

description: Endometrial carcinoma that has spread to nearby tissues or lymph nodes.


name: Locally Advanced Endometrial Adenocarcinoma

description: Endometrial adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Locally Advanced Unresectable Endometrial Carcinoma

description: Endometrial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Locally Advanced Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


BENZETHONIUM CHLORIDE

A (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. An antiseptic and disinfectant, it is active against a broad spectrum of bacteria, fungi, moulds and viruses.


name: collagen alpha-1(II) chain isoform m4 (mouse)

description: A collagen alpha-1(II) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28481-4.


name: CO2A1_MOUSE Collagen alpha-1(II) chain (sprot)

description: A collagen type II alpha chain that is encoded in the genome of mouse.


name: collagen alpha-1(II) chain isoform m7 (mouse)

description: A collagen alpha-1(II) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28481-7.


name: collagen alpha-1(II) chain isoform m6 (mouse)

description: A collagen alpha-1(II) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28481-6.


name: collagen alpha-1(II) chain isoform m2 (mouse)

description: A collagen alpha-1(II) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28481-1.


name: collagen alpha-1(II) chain isoform m1 (mouse)

description: A collagen alpha-1(II) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28481-3.


name: collagen alpha-1(II) chain isoform m3 (mouse)

description: A collagen alpha-1(II) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28481-2.


name: collagen alpha-1(II) chain isoform m5 (mouse)

description: A collagen alpha-1(II) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28481-5.


Stage IVB Thymoma AJCC v8

description: Stage IVB includes: (Any T, N2, M0, M1a); (Any T, Any N, M1b). N2: Metastasis in deep intrathoracic or cervical lymph nodes. M0: No distant metastasis. M1a: Separate pleural or pericardial nodule(s). M1b: Pulmonary intraparenchymal nodule or distant organ metastasis. (AJCC 8th ed.)


name: Stage IVB Thymic Epithelial Neoplasm AJCC v8


name: zinc finger protein 746 cysteinylated 1 (human)

description: A zinc finger protein 746 (human) that has been cysteinylated on the residue at the position equivalent to Cys-49 of the amino acid sequence represented by UniProtKB:Q6NUN9-1. Example: UniProtKB:Q6NUN9-1, Cys-49, MOD:00765.


name: glutamate decarboxylase 2 isoform 1 (Arabidopsis thaliana)

description: A glutamate decarboxylase 2 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q42472-1.


name: DCE2_ARATH Glutamate decarboxylase 2 (sprot)

description: A protein that is a translation product of the GAD2 gene in Arabidopsis thaliana.


name: leukocyte tyrosine kinase receptor isoform D (mouse)

description: A leukocyte tyrosine kinase receptor (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08923-1.


A cholesterol ester in which the acyl group contains 20 carbons in total and 4 double bonds.


name: cellular tumor antigen p53 sequence variant S166* (human)

description: A cellular tumor antigen p53 (human) that has has been truncated after the position equivalent to Gln-165 of the amino acid sequence represented by UniProtKB:P04637-1. Example: UniProtKB:P04637-1, 1-165.


name: MFG1_CANAL Morphogenetic regulator of filamentous growth protein 1 (sprot)

description: A protein that is a translation product of the MFG1 gene in Candida albicans SC5314.


name: small ribosomal subunit protein mS39 methylated 1 (human)

description: A small ribosomal subunit protein mS39 (human) that has been methylated on the residue at the position equivalent to Cys-551 of the amino acid sequence represented by UniProtKB:Q96EY7-1. Example: UniProtKB:Q96EY7-1, Cys-551, MOD:00660.


name: UPF0725 protein At1g23950 isoform 5 (Arabidopsis thaliana)

description: A UPF0725 protein At1g23950 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9LR97-5.


name: ESF13_ARATH EMBRYO SURROUNDING FACTOR 1.3 (sprot)

description: A protein that is a translation product of the ESF1.3 gene in Arabidopsis thaliana.


name: cysteine-rich receptor-like protein kinase 21 isoform 2 (Arabidopsis thaliana)

description: A cysteine-rich receptor-like protein kinase 21 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3E9X6-2.


name: G6PI_ARATH Glucose-6-phosphate isomerase, cytosolic (sprot)

description: A glucose-6-phosphate isomerase that is encoded in the genome of Arabidopsis thaliana.


name: influenza virus NS1A-binding protein homolog isoform m4 (mouse)

description: An influenza virus NS1A-binding protein homolog (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q920Q8-4.


pediatric cerebral ependymoblastoma

description: An embryonal tumor with multilayered rosettes, C19MC-altered that arises from the cerebral hemispheres and occurs in children.


name: childhood cerebellar astrocytic neoplasm

description: Benign and malignant astrocytomas that arise from astrocytes in the cerebellum. More than 80% of childhood cerebellar astrocytomas are pilocytic astrocytomas which have a favorable prognosis. The remainder are composed of diffuse or fibrillary subtypes with malignant astrocytomas occurring only rarely in the cerebellum during childhood.


name: supratentorial ependymoma, ZFTA fusion–positive

description: A suptratentorial ependymoma that is characterized by the presence of a fusion gene involving ZFTA gene.


childhood brainstem astrocytoma

description: An astrocytoma that arises from the brain stem and occurs during childhood.


proneural glioblastoma

description: A molecular subtype of glioblastoma that is associated with younger age at presentation and is characterized by p53 mutations and PDGFRa amplifications.


name: pineal parenchymal tumor of intermediate differentiation

description: A WHO grade II or III pineal parenchymal neoplasm of intermediate-grade malignancy, affecting all ages. It is composed of diffuse sheets or large lobules of uniform cells with mild to moderate nuclear atypia and low to moderate level mitotic activity. (Adapted from WHO)


desmoplastic infantile astrocytoma

description: A WHO grade I large cystic tumor that occurs almost exclusively in infants, with a prominent desmoplastic stroma having a neuroepithelial population consisting mainly of neoplastic astrocytes. It involves the superficial cerebral cortex and leptomeninges, and often attaches to the dura. Although clinically it presents as large tumor, it generally has a good prognosis following surgical resection. (Adapted from WHO)


astroblastoma

description: Astroblastoma is a very rare glial neoplasm of the central nervous system, most often with an intra-axial peripheral supratentorial location in one hemisphere of the frontal or parietal lobes and usually presenting in infants and young adults with symptoms of vomiting, loss of consciousness, epileptic seizures and headaches.


IDH-mutant anaplastic astrocytoma

description: An anaplastic astrocytoma carrying IDH mutations.


melanotic neuroectodermal tumor

description: A rare neoplasm usually occurring in infants. It is characterized by the presence of a mixture of melanin-containing epithelial cells and smaller neuroblast-like cells. It may involve the skull and facial bones, or the epididymis. It usually has a benign clinical course.


desmoplastic infantile ganglioglioma

description: A WHO grade I large cystic tumor that occurs almost exclusively in infants, with a prominent desmoplastic stroma having a neuroepithelial population of neoplastic astrocytes together with a variable neuronal component. It involves the superficial cerebral cortex and leptomeninges, and often attaches to the dura. Although clinically it presents as a large tumor, it generally has a good prognosis following surgical resection. (Adapted from WHO)


extraventricular neurocytoma

description: Extraventricular neurocytoma (EVN), a variant of central neurocytoma, is a rare neuronal neoplasm, composed of round cells with neuronal differentiation, which is located outside of the ventricular system, usually within the spinal cord or cerebral hemispheres and that manifests with headache, nausea, vomiting, complex partial seizures or focal neurological deficits. In some cases it may exhibit atypical features consistent with aggressive clinical behavior.


papillary glioneuronal tumor

description: A WHO grade I, indolent and relatively circumscribed brain tumor. Morphologically it is characterized by the presence of astrocytes that line vascular and hyalinized pseudopapillae. In between the pseudopapillae aggregates of neurocytes, large neurons, and ganglioid cells are present.


name: melanotic psammomatous malignant peripheral nerve sheath tumor

description: A malignant peripheral nerve sheath tumor characterized by the presence of malignant cells that contain melanin and formation of psammoma bodies.


tanycytic ependymoma

description: A variant of ependymoma, often found in the spinal cord, with tumor cells arranged in fascicles of variable width and cell density. Ependymal rosettes are generally absent, so this lesion must be distinguished from astrocytic neoplasms, but its EM characteristics are ependymal. (Adapted from WHO.)


cerebral neuroblastoma

description: A neuroblastoma arising from the cerebral hemispheres.


name: childhood supratentorial embryonal tumor with multilayered rosettes, C19MC-altered

description: A childhood embryonal tumor with multilayered rosettes, C19MC-altered that arises from the supratentorial brain and occurs in children.


anaplastic astrocytoma

description: Anaplastic astrocytoma is a rare, high-grade, malignant glial tumor, histologically characterized by abundance of pleomorphic astrocytes and multiple mitotic figures, often associated with diffuse infiltration of the surrounding tissue, considerable edema and mass effect and involvement of the contralateral brain. Depending on the primary localization of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), seizures, progressive neurological deficits, and/or behavioral changes. The tumor is most commonly localized in the frontal and temporal lobes, brain stem and spinal cord.


name: spinal cord primitive neuroectodermal tumor

description: A central nervous system embryonal tumor, not otherwise specified arising from the spinal cord.


brain stem astrocytic neoplasm

description: An astrocytoma that arises from the brain stem.


mediastinal schwannoma

description: A schwannoma that arises from the posterior mediastinum. It is the most common neurogenic tumor of the mediastinum. Excision is usually curative.


benign glioma

description: A form of glioma without malignant characteristics.


papillary ependymoma

description: A rare variant of ependymoma characterized by well formed papillae. Tumor cell processes abutting capillaries are usually GFAP-positive. Differential diagnoses include choroid plexus papilloma, papillary meningioma and metastatic papillary carcinoma. (Adapted from WHO)


adrenal gland ganglioneuroblastoma

description: A ganglioneuroblastoma arising from the adrenal gland.


pineal gland astrocytoma

description: A astrocytoma that involves the pineal body.


posterior fossa group A ependymoma

description: A posterior fossa ependymoma that arises in the posterior fossa with characteristic DNA methylation patterns, including CpG island hypermethylation, global DNA hypomethylation, reduction of nuclear H3 p.K28me3 (K27me3) expression, and EZHIP overexpression.


gangliocytoma

description: A well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, mature ganglion cells.


trigeminal schwannoma

description: A schwannoma that involves the trigeminal nerve.


childhood ependymoma

description: An ependymoma that arises from the central nervous system and occurs during childhood.


oligoastrocytoma

description: A WHO grade II tumor composed of a conspicuous mixture of two distinct neoplastic cell types morphologically resembling the tumor cells in oligodendroglioma and diffuse astrocytoma. (WHO)


gliomatosis cerebri

description: A diffuse glial tumor which infiltrates the brain extensively, involving more than two lobes. It is frequently bilateral and often extends to the infratentorial structures, even to the spinal cord. It is probably of astrocytic origin, although GFAP expression may be scant or absent. (Adapted from WHO.)


Pacinian tumor

description: A neurofibroma characterized by the presence of structures which resemble Vater-Pacini corpuscles.


adult anaplastic ependymoma

description: An anaplastic ependymoma occurring in adults.


optic tract astrocytoma

description: An astrocytoma that affects the optic tract. This condition can be seen in association with neurofibromatosis 1. It is most commonly seen in the pediatric age group.


neurothekeoma

description: A benign neoplasm arising from nerve sheaths. It is characterized by the presence of a myxoid stroma.


brain glioma

description: A malignant glioma that involves the brain.


name: peripheral primitive neuroectodermal tumor of bone

description: A small round cell tumor with neural differentiation arising from the bone. It may be associated with pain.


name: primitive neuroectodermal tumor of the corpus uteri

description: A primitive neuroectodermal tumor that involves the body of uterus.


extracranial neuroblastoma

description: A neuroblastoma arising from an anatomic site other than the brain.


spinal cord neuroblastoma

description: A neuroblastoma that affects the spinal cord.


spinal ependymoma, MYCN-amplified

description: A spinal cord ependymoma that is characterized by MYCN amplification.


name: neurofibromatosis, type III, mixed central and peripheral


mesenchymal glioblastoma

description: A molecular subtype of glioblastoma characterized by the presence of NF1 mutations.


name: malignant cardiac peripheral nerve sheath neoplasm

description: A very rare malignant peripheral nerve sheath tumor that arises from the heart.


ependymal tumor

description: A group of neoplasms which arise from the ependymal lining of the cerebral ventricles and from the remnants of the central canal of the spinal cord. Ependymal tumors occur predominantly in children and young adults with varied morphological features and biological behavior. There are 4 types: ependymoma, anaplastic ependymoma, myxopapillary ependymoma and subependymoma. (WHO)


perineurioma

description: A usually benign perineurioma not associated with a nerve, arising from the soft tissues.


adult brainstem astrocytoma

description: An astrocytoma of the brain stem that occurs during adulthood.


IDH-wildtype anaplastic astrocytoma

description: An anaplastic astrocytoma lacking mutations in IDH1 or IDH2 genes.


schwannoma of twelfth cranial nerve

description: A schwannoma that involves the hypoglossal nerve.


astrocytoma, IDH-mutant, grade 4

description: An IDH-mutant anaplastic astrocytoma that is characterized by the presence of necrosis and/or microvascular proliferation or homozygous deletion of CDKN2A and/or CDKN2B genes. The term glioblastoma no longer applies to central nervous system WHO grade 4 IDH-mutant astrocytomas.


adult pineal parenchymal tumor

description: A pineal parenchymal cell neoplasm (pineocytoma or pineoblastoma) occurring in adults.


spinal cord oligodendroglioma

description: A oligodendroglioma that involves the spinal cord.


optic nerve astrocytoma

description: A astrocytoma (excluding glioblastoma) that involves the cranial nerve II.


posterior fossa group B ependymoma

description: A posterior fossa ependymoma that arises in the posterior fossa with characteristic DNA methylation patterns including retention of nuclear H3 p.K28me3 (K27me3) expression, absence of CpG island hypermethylation, absence of global DNA hypomethylation, and absence of EZHIP overexpression.


differentiating neuroblastoma

description: A neuroblastoma in which the differentiating neuroblasts constitute more than five-percent of the tumor cells.


adult brainstem gliosarcoma

description: A gliosarcoma of the brain stem that occurs during adulthood.


malignant triton tumor

description: Malignant triton tumor (MTT) is a rare aggressive subtype of malignant peripheral nerve sheath tumor (MPNST) characterized histopathologically by focal rhabdomyoblastic differentiation.


childhood optic nerve glioma

description: A glioma affecting the optic tract and occurring in childhood.


peripheral nerve schwannoma

description: A benign, usually encapsulated slow growing tumor of the peripheral nervous system composed of Schwann cells. It recurs infrequently and only rare cases associated with malignant transformation have been reported.


low grade glioma

description: A grade I or grade II glioma arising from the central nervous system. This category includes pilocytic astrocytoma, diffuse astrocytoma, subependymal giant cell astrocytoma, ependymoma, oligodendroglioma, oligoastrocytoma, and angiocentric glioma.


name: stroma-dominant and stroma-poor composite ganglioneuroblastoma

description: A neuroblastic tumor characterized by the presence of a ganglioneuroblastoma component and the formation of Schwannian stroma which is the predominant component of the tumor volume.


anaplastic oligodendroglioma

description: A WHO grade III oligodendroglioma with focal or diffuse malignant morphologic features (prominent nuclear pleomorphism, mitoses, and increased cellularity).


grade II glioma

description: A glioma arising from the central nervous system. This category includes diffuse astrocytoma, ependymoma, oligodendroglioma, and oligoastrocytoma.


optic pathway glioma

description: Optic pathway glioma (OPG) is a benign tumor that develop along the optic nerve (chiasm, tracts, and radiations) characterized by impairment or loss of vision and may be accompanied by diencephalic symptoms such as reduced growth and alteration in sleeping patterns. OPG are often linked to neurofibromatosis type 1 (NF1).


name: diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype

description: A high grade glioma that is characterized by the absence of histone H3, IDH1, and IDH2 mutations.


juvenile pilocytic astrocytoma

description: A pilocytic astrocytoma that occurs during adolescence.


clear cell ependymoma

description: An ependymoma, often supratentorial in location, characterized by the presence of ependymal cells with a perinuclear halo.


name: high-grade astrocytoma with piloid features

description: An anaplastic astrocytoma that is characterized by high-grade piloid and/or glioblastoma-like histological features. It may occur anywhere in the central nervous system but most often arises in the posterior fossa.


name: pleomorphic xanthoastrocytoma BRAF mutant

description: An anaplastic pleomorphic xanthoastrocytoma that has material basis in BRAF mutations.


anaplastic oligoastrocytoma

description: An oligoastrocytoma characterized by the presence of increased cellularity, nuclear atypia, pleomorphism, and high mitotic activity.


name: childhood central nervous system primitive neuroectodermal neoplasm

description: A central nervous system embryonal tumor, not otherwise specified that occurs in childhood.


malignant peripheral nerve sheath tumor

description: Malignant peripheral nerve sheath tumor (MPNST) is a rare and often aggressive soft tissue sarcoma occurring in a wide range of anatomical sites.


gliofibroma

description: An astrocytic tumor affecting young people. Morphologically, it is characterized by the presence of collagenous tissue surrounding neoplastic astrocytes. In some cases the collagen is produced by the tumor cells (desmoplastic astrocytoma), whereas in others it is produced by mesenchymal cells (mixed glioma/fibroma).


atypical neurofibroma

description: A neurofibroma characterized by the presence of cellular pleomorphism.


name: supratentorial ependymoma, YAP1 fusion–positive

description: A supratentorial ependymoma that is characterized by the presence of a fusion gene involving YAP1 gene.


name: peripheral primitive neuroectodermal tumor of soft tissues

description: A small round cell tumor with neural differentiation arising from the soft tissues.


name: schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma

description: A neuroblastic tumor characterized by the presence of a ganglioneuroblastoma component and the formation of Schwannian stroma which constitutes more than fifty-percent of the tumor volume.


peripheral ganglioneuroblastoma

description: A ganglioneuroblastoma arising from the peripheral nervous system.


chordoid glioma of the third ventricle

description: A rare, slow-growing neuroepithelial neoplasm of uncertain origin affecting adults. It is located in the third ventricle. It is characterized by the presence of epithelioid cells which express GFAP, and mucinous stroma which contains lymphoplasmacytic infiltrates.


name: malignant melanocytic peripheral nerve sheath tumor of mediastinum

description: A rare variant of malignant peripheral nerve sheath tumor that arises from the mediastinum. It is characterized by the presence of malignant cells that contain melanin.


childhood astrocytic tumor

description: An astrocytic tumor appearing before the age of twenty one without designation of benign or malignant nor designated location.


name: malignant cutaneous granular cell skin tumor

description: A malignant granular cell tumor that arises from the skin.


neural glioblastoma

description: A molecular subtype of glioblastoma characterized by the expression of the neural markers NEFL, GABRA1, SYT1, and SLC12A5.


name: diffuse astrocytoma, MYB- or MYBL1-altered

description: A diffuse astrocytoma that is a diffusely infiltrative astroglial neoplasm composed of monomorphic cells with genetic alterations in MYB or MYBL1.


granular cell leiomyosarcoma

description: An aggressive malignant smooth muscle neoplasm. It is characterized by the presence of malignant smooth muscle cells with granular cytoplasmic changes.


name: benign mediastinal psammomatous neurilemmoma

description: A schwannoma that arises from the posterior mediastinum. It is characterized by the presence of psammoma bodies.


ependymal tumor of spinal cord

description: An ependymal tumor that arises from the spinal cord.


brain stem ependymoma

description: An ependymoma that arises from the brain stem.


grade III glioma

description: A group of malignant gliomas that includes anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma, and anaplastic ependymoma.


childhood low-grade glioma

description: A low-grade glioma that occurs in children and encompasses tumors of astrocytic, oligodendroglial, and mixed glial-neuronal histology.


name: adult embryonal tumor with multilayered rosettes, c19mc-altered

description: An embryonal tumor with multilayered rosettes, C19MC-altered, occurring in adults.


diffuse glioma, H3 G34 mutant

description: A histone mutated tumor that has material basis in mutations in codon 34 of the H3 histone family 3A protein.


classical glioblastoma

description: A molecular subtype of glioblastoma characterized by lack of p53 mutations, chromosome 7 amplifications or deletions, and high levels of EGFR amplification.


spinal cord glioma

description: A neoplasm that arises from glial cells in the spinal cord. Representative examples include astrocytoma, oligodendroglioma, and ependymoma.


adult brainstem glioma

description: A brain stem glioma that occurs in an adult.


myxopapillary ependymoma

description: Myxopapillary ependymoma (MEPN) describes a slow growing ependymoma located almost exclusively in the conus medullaris-cauda equina-filum terminale region of the spinal cord, presenting in all age groups, and manifesting with variable symptoms such as neck pain, vomiting and unsteady gait and metastasis. It has a more aggressive disease course and is seen in the pediatric population.


astroblastoma, MN1-altered

description: An astroblastoma that is characterized by astroblastoma-like morphology with MN1 rearrangements involving the meningioma 1 (MN1) gene on chromosome 22q.


mediastinal granular cell myoblastoma

description: An exceptionally rare, generally benign, granular cell tumor that arises from the mediastinum. All the reported cases were located in the posterior mediastinum.


name: oligodendroglioma, IDH-mutant and 1p/19q-codeleted grade 2

description: An IDH-mutant, and 1p/19q-codeleted oligodendroglioma that is characterized as a well differentiated tumor lacking anaplastic features (brisk mitotic activity, microvascular proliferation, necrosis).


sympathetic neurilemmoma

description: A benign tumor derived from schwann cells of the peripheral sympathetic nervous system, including the sympathetic plexus.


cellular ependymoma

description: An ependymoma which shows conspicuous cellularity without a significant increase in mitotic rate. (Adapted from WHO)


adult oligodendroglioma

description: An oligodendroglioma occurring during adulthood.


name: IDH-mutant and 1p/19q-codeleted oligodendroglioma

description: An anaplastic oligodendroglioma that has material basis in IDH gene family mutation and combined whole-arm losses of 1p and 19q (1p/19q codeletion).


description: An embryonal tumor with multilayered rosettes, C19MC-altered that arises from the infratentorial region and occurs in children.


papillary tumor of the pineal region

description: Papillary tumor of the pineal region (PTPR) is a very rare neoplasm of the pineal region that is thought to arise from the specialized ependymocytes of the subcommissural organ and that manifests with visual disturbances, headaches, loss of coordination and balance, nausea and vomiting due to obstructive hydrocephalus.


high grade astrocytic tumor

description: An anaplastic astrocytoma (grade III astrocytic tumor) or glioblastoma (grade IV astrocytic tumor).


malignant perineurioma

description: A very rare malignant tumor with morphologic features similar to those of benign perineurioma of soft tissue along with hypercellularity, nuclear atypia, hyperchromasia, and a high mitotic rate.


cerebellar pilocytic astrocytoma

description: A WHO Grade 1 astrocytoma which arises in the cerebellum. The tumor is composed of spindle shaped cells with numerous collections of reddish astrocytic fibers called Rosenthal fibers. Over 80% or the cerebellar astrocytomas of childhood are pilocytic. Pilocytic astrocytomas may rarely occur in adults. They are usually treated by surgical resection and in most cases have a favorable prognosis.


retroperitoneal neuroblastoma

description: A neuroblastoma that involves the retroperitoneal space.


name: intracranial primitive neuroectodermal tumor

description: A primitive neuroectodermal tumor that involves the brain.


adult pineoblastoma

description: A pineoblastoma occurring in adults.


low grade astrocytic tumor

description: A grade I or grade II astrocytic tumor. This category includes pilocytic astrocytoma (grade I), subependymal giant cell astrocytoma (grade I), and diffuse astrocytoma (grade II).


childhood pilocytic astrocytoma

description: A pilocytic astrocytoma that occurs during childhood.


infant-type hemispheric glioma

description: A malignant astrocytoma that is characterized by receptor tyrosine kinase fusions in the NTRK family, ROS1, ALK, or MET genes, that arises in the cerebral hemisphere and occurs in early childhood.


diffuse astrocytoma

description: A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse infiltration of neighboring central nervous system structures. These lesions typically affect young adults and have a tendency for progression to anaplastic astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified.


gemistocytic astrocytoma

description: A rare variant of diffuse astrocytoma. It is characterized by the presence of a conspicuous, though variable, fraction of gemistocytic neoplastic astrocytes. Gemistocytes are round to oval astrocytes with abundant, glassy, non-fibrillary cytoplasm which appears to displace the dark, angulated nucleus to the periphery of the cell. To make the diagnosis of gemistocytic astrocytoma, gemistocytes should amount to more than approximately 20% of all tumor cells. (Adapted from WHO)


name: oligodendroglioma, IDH-mutant and 1p/19q-codeleted, grade 3

description: An IDH-mutant, and 1p/19q-codeleted oligodendroglioma that is characterized as grade 3 tumors associated with a more rapid growth. Grade 3 tumors appear to have abnormalities on chromosomes 9 or 10, along with unusual amounts of growth factors and proteins, which are thought to contribute to the more rapid growth of these gliomas.


brain oligodendroglioma

description: A oligodendroglioma that involves the brain.


adult brainstem mixed glioma

description: A mixed glioma of the brain stem that occurs during adulthood.


description: A mixed glioma characterized by the presence of astrocytic, ependymal, and oligodendroglial neoplastic components.


name: intermixed schwannian stroma-rich ganglioneuroblastoma

description: A ganglioneuroblastoma characterized by the presence of neuroblastic cells in a Schwannian stroma, without the presence of hemorrhagic neuroblastic nodules.


adult infiltrating astrocytic neoplasm

description: An infiltrating astrocytic tumor of the brain occurring in adults.


plexiform schwannoma

description: A schwannoma characterized by a plexiform or multinodular growth pattern. It usually arises from the skin or subcutaneous tissues in the extremities, trunk, and head and neck.


posterior fossa ependymoma

description: A high grade ependymoma that is located within the posterior fossa.


cerebral astrocytoma

description: An astrocytoma that arises from the cerebral hemispheres.


oligodendroglial tumor

description: Oligodendrogliomas are cerebral tumors that are differentiated from other gliomas on the basis of their unique genetic characteristics and better response to chemotherapy. These tumors are classified according to their grade (low grade oligodendrogliomas: grade II of the WHO classification and anaplastic oligodendrogliomas: grade III of the WHO classification) and according to their pure or mixed histology (oligoastrocytomas).


epithelioid neurofibroma

description: A rare neurofibroma with epithelioid morphology.


granular cell cancer

description: An uncommon granular cell tumor which may metastasize to other anatomic sites. Morphologic characteristics include the presence of spindling neoplastic cells, necrosis, extensive pleomorphism, prominent nucleoli, and increased mitiotic activity.


childhood optic tract astrocytoma

description: An astrocytoma that arises from the visual pathway and occurs during childhood.


name: diffuse low-grade glioma, MAPK pathway–altered

description: A low grade glioma that is characterized by a gene alteration that results in a MAPK pathway abnormality, with morphological features of astrocytoma or oligodendroglioma.


nasal ganglioglioma

description: Nasal ganglioglioma is a rare tumor, presenting in newborns, containing both neuronal and astrocytic components and that can be endonasal, extranasal or both. It is usually identified as a nasal mass that may cause feeding difficulties and nasal obstruction.


olfactory neuroblastoma

description: An olfactory neuroblastoma arising in the paranasal sinus.


melanotic neurilemmoma

description: A rare circumscribed, non-encapsulated and grossly pigmented nerve sheath tumor. It is composed of cells with the immunophenotypic and electron microscopic features of Schwann cells which contain melanosomes and are positive for melanoma markers. It usually involves spinal nerve roots but may occur in other locations. It may be associated with PRKAR1A gene mutation and Carney complex. Malignant behavior has been reported in a significant number of patients.


RELA fusion-positive ependymoma

description: A supratentorial ependymoma characterized by a gene fusion involving ZFTA and RELA genes. It accounts for the majority of supratentorial ependymomas in children. It has an unfavorable outcome when compared to other ependymoma subtypes.


cellular schwannoma

description: A morphologic variant of schwannoma characterized by hypercellularity, Antoni A pattern, and the absence of well-formed Verocay bodies.


extraneural perineurioma

description: Extraneural perineurioma is a rare tumor of cranial and spinal nerves arising from peripheral nerve sheet and composed exclusively or predominantly of cells showing perineurial differentiation. It presents as a well-circumscribed, rarely encapsulated mass, not associated with a recognizable nerve, most commonly arising in the dermis and subcutis of the extremities or trunk, or, rarely, in deep soft tissue or skin (e.g., in the stomach, kidney, pancreas, maxillary sinus, mandible, bronchial tree and the face). The clinical presentation depends on the localization.


cerebellar astrocytoma

description: Benign and malignant neoplasms of the cerebellum that arise from astrocytes. During childhood the majority are benign pilocytic astrocytomas. In adults both benign and relatively higher grade forms may occur. The most common presenting symptoms are headache, nausea, vomiting, ataxia of gait or limb, paresis, diplopia, and dizziness. Objective signs include weakness, long tract signs, dysmetria, gait ataxia, papilledema, and nystagmus. Surgical resection is often curative.


adult malignant schwannoma

description: A malignant peripheral nerve sheath tumor occurring during adulthood.


adult brain ependymoma

description: An ependymoma of the brain occurring in adults.


intraneural perineurioma

description: A WHO grade I perineurioma that arises within the endoneurium. It is characterized by the formation of pseudo-onion bulbs by the proliferating perineural cells.


retinal neuroblastoma

description: A neuroblastoma arising from the retina.


ependymal tumor of brain

description: A tumor arising from the ependymal lining of the ventricles.


vulvar granular cell tumor

description: A usually benign granular cell tumor that arises from the vulva.


description: A malignant astrocytoma that is characterized by the presence of five or more mitoses per 10 high-power fields.


spinal cord astrocytoma

description: A low or high grade astrocytoma that arises in the spinal cord.


mixed astrocytoma-ependymoma

description: A tumor of mixed cell type with astrocytic components as well as ependymoma components.


diffuse intrinsic pontine glioma

description: A neuroglial tumor that arises from the middle portion of the brain stem. It usually affects children and has a poor prognosis.


diffuse midline glioma, H3 K27M-mutant

description: A histone mutated tumor that is characterized by the presence of histone H3 K27M mutation located throughout the midline structures of the central nervous system.


mediastinum ganglioneuroblastoma

description: A ganglioneuroblastoma arising from the mediastinum.


name: epithelioid malignant peripheral nerve sheath tumor

description: A rare variant of malignant peripheral nerve sheath tumor composed predominantly or exclusively of epithelioid cells.


subependymoma

description: Subependymoma is a rare and slow growing type of ependymoma, often presenting in middle-aged adults, found more commonly in men than in women, usually located in the fourth and lateral ventricles and manifesting with variable symptoms including headache, nausea, and loss of balance. In some cases it can be asymptomatic. It is usually associated with a better prognosis than other forms of ependymoma.


Askin tumor

description: A primitive neuroectodermal tumor (small round blue cell tumor) of the thorax which can involve the periosteum, thoracic wall and/or pleura though it spares the lung parenchyma.


protoplasmic astrocytoma

description: A rare variant of diffuse astrocytoma. It is predominantly composed of neoplastic astrocytes showing a small cell body with few, flaccid processes with a low content of glial filaments and scant GFAP expression. This lesion is not well defined and is considered by some authors as an occasional histopathological feature rather than a reproducibly identifiable variant. When occurring in children, this neoplasm may be difficult to separate from pilocytic juvenile astrocytoma. (Adapted from WHO)


mediastinal melanocytic neurilemmoma

description: A melanotic schwannoma that affects the mediastinum.


neurohypophysis granular cell tumor

description: A generally benign intrasellar and/or suprasellar mass arising from the neurohypophysis or infundibulum. It is composed of nests of large cells with granular, eosinophilic cytoplasm due to abundant intracytoplasmic lysosomes. It generally has a slow progression and lacks invasive growth. (Adapted from WHO)


pilomyxoid astrocytoma

description: An astrocytic tumor of uncertain relation to pilocytic astrocytoma. It occurs predominantly in infants and young children. It is characterized by a monomorphic architectural pattern, usually associated with the absence of Rosenthal fibers and eosinophilic granular bodies. The clinical course is usually aggressive.


nodular ganglioneuroblastoma

description: A ganglioneuroblastoma characterized by the presence of neuroblastic cells in a Schwannian stroma, and the formation of hemorrhagic neuroblastic nodules.


name: YAP1-MAMLD1 fusion-positive supratentorial ependymoma

description: A supratentorial ependymoma that has material basis in YAP1-MAMLD1 fusion.


neuroepithelioma

description: Peripheral neuroepithelioma is a rare noncentral nervous system tumor with evidence of primitive neuroectodermal differentiation.


childhood malignant schwannoma

description: A malignant peripheral nerve sheath tumor occurring in children.


IDH-wildtype glioblastoma

description: A glioblastoma that is characterized by high cellularity, high mitotic activity, necrosis or microvascular proliferation and that lacks mutations in IDH genes.


nerve sheath neoplasm

description: A benign or malignant neoplasm arising from the perineural cells in the sheaths surrounding the nerves. Representative examples include neurofibroma, schwannoma, and malignant peripheral nerve sheath tumor.


supratentorial ependymal tumor

description: An ependymal tumor arising from the supratentorial region of the brain.


adult spinal cord ependymoma

description: An ependymoma of the spinal cord occurring in adults.


frontal lobe ependymal tumor

description: An ependymal tumor affecting the frontal lobe of the brain.


anaplastic ependymoma

description: Anaplastic ependymoma is a rare, malignant type of ependymoma that most often arises in the supratentorial region of the brain of children and young adults and that manifests with variable symptoms including headaches, nausea, vision impairment, memory loss and difficulty walking.


angiocentric glioma

description: Angiocentric glioma (AG) is an extremely rare slow-growing glial neoplasm of the central nervous system, usually arising in a superficial location in the cerebrum, affecting all ages and both sexes, and characterized by intractable seizures and headaches, with most cases being cured by surgical incision alone and therefore having a good prognosis.


cervical neuroblastoma

description: A relatively uncommon neuroblastoma that is found in the neck.


adrenal gland neuroblastoma

description: A neuroblastoma arising from the adrenal gland.


infratentorial ependymal tumor

description: An ependymal tumor arising from the infratentorial region of the brain.


mediastinum neurofibroma

description: A neurofibroma that arises from the posterior mediastinum. Excision is usually curative.


name: cauda equina intradural extramedullary astrocytoma


nasal cavity olfactory neuroblastoma

description: An olfactory neuroblastoma arising in the nasal cavity.


corpus callosum oligodendroglioma

description: A oligodendroglioma that involves the corpus callosum.


name: malignant melanocytic neoplasm of the peripheral nerve sheath

description: A rare variant of malignant peripheral nerve sheath tumor. It is characterized by the presence of malignant cells that contain melanin.


anaplastic ganglioglioma

description: A WHO grade III neuroepithelial neoplasm composed of neoplastic, mature ganglion cells and anaplastic glial cells. The anaplastic changes in the glial component and high MIB-1 and TP53 labeling indices may indicate aggressive behavior. However, the correlation of histological anaplasia with clinical outcome is inconsistent. (Adapted from WHO)


astrocytoma, IDH-mutant, grade 3

description: An IDH-mutant anaplastic astrocytoma that is characterized by the presence of increased mitotic activity and anaplastic features.


mixed glioma

description: A tumor composed of two or more glial cell types (astrocytes, ependymal cells, and oligodendrocytes).


cutaneous ganglioneuroma

description: A ganglioneuroma arising from the skin.


adult spinal cord glioblastoma

description: A rare spinal tumor which is highly malignant and tends to be locally invasive of surrounding neural tissue. The tumor also tends to spread throughout the neuroaxis and is often rapidly progressive. Histologically the tumors are highly cellular with nuclear and cellular pleomorphism, endothelial proliferation, mitotic figures, and, often, necrosis. This tumor has a relatively poor prognosis. Clinical features may include pain followed by rapidly progressive neurologic deficits such as extremity weakness, sensory changes, spasticity, and incontinence. (From Innocenzi et al., Clin Neurol Neurosurg 1997 Feb;99(1):1-5)


malignant glioma

description: A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma.


name: central nervous system tumor with bcor internal tandem duplication

description: A central nervous system embryonal tumor that is characterized by the presence of uniform oval or spindle-shaped cells with round or oval nuclei, pseudorosette formation, and heterozygous internal tandem duplication in exon 15 of the BCOR gene.


parietal lobe ependymal tumor

description: An ependymal tumor affecting the parietal lobe of the brain.


schwannoma of ureter

description: A benign nerve sheath tumor composed of Schwann cells, occurring in the ureter.


mediastinum neuroblastoma

description: A neuroblastoma arising from the mediastinum.


childhood brain stem glioma

description: An abnormal growth of the cells that comprise the tissues of the brainstem. While the tumor may be histologically benign, it can produce great morbidity due to its location. It presents most commonly in the first two decades of life.


diencephalic astrocytomas

description: A astrocytoma that involves the diencephalon.


microcystic/reticular schwannoma

description: The rarest histopathologic subtype of Schwannoma. The reported cases have been located in the gastrointestinal submucosa or subcutaneous tissue. Morphologically it is characterized by the presence of a microcyst-rich network of spindle cells with minimal amount of cytoplasm and Antoni A tissue.


dopaminergic neuroblastoma

description: A neuroblastoma associated with increased dopamine excretion.


cellular neurofibroma

description: A neurofibroma characterized by the presence of areas with increased cellularity.


description: Desmoplastic infantile astrocytoma/ganglioglioma are mixed neuronal-glial tumors representing a histological spectrum of the same tumor. They are usually supratentorially located, large, cystic masses with a peripheral solid component, characterized by prominent desmoplastic stroma and pleomorphic populations of neoplastic cells with either astrocytic or ganglionic differentiation and poorly differentiated cells in variable proportions. They usually present in the first 18 months of age with rapid head growth, bulging anterior fontanel and bone structures over the tumor, signs of raised intracranial pressure (headache, vomiting, papilledema), focal neurological signs and sometimes seizures.


spinal cord ependymoma

description: An ependymoma that arises from the spinal cord.


astrocytoma, IDH-mutant, grade 2

description: An IDH-mutant anaplastic astrocytoma that is characterized by the presence of well-differentiated fibrillary glial cells diffusely infiltrating the central nervous system.


pediatric infratentorial ependymoma

description: An ependymoma that arises from the infratentorial region of the brain and occurs during childhood.


cns neuroblastoma with FOXR2 activation

description: A central nervous system neuroblastoma that is characterized by FOXR2 activation and that is composed of small, round cells with hyperchromatic nuclei surrounded by a clear halo.


cutaneous granular cell tumor

description: A granular cell tumor that involves the zone of skin.


adult glioblastoma

description: A glioblastoma occurring in adults.


brain glioblastoma

description: A WHO grade IV malignant astrocytic tumor that arises from the brain, usually the cerebral hemispheres. It is characterized by the presence of poorly differentiated astrocytes, cellular polymorphism, nuclear atypia, and increased mitotic activity. The prognosis is poor.


breast granular cell tumor

description: A usually benign neoplasm that arises from the breast. It presents as a single, firm, and painless mass. It is characterized by the presence of neoplastic cells with eosinophilic granular cytoplasm.


schwannomatosis

description: The least frequent form of the rare genetic disorder neurofibromatosis. It is clinically and genetically distinct from NF1 and NF2 and is characterized by the development of multiple schwannomas (nerve sheath tumors), without involvement of the vestibular nerves. NF3 develops in adulthood and is often associated with chronic pain. Dysesthesia and paresthesia may also be present. Common localizations include the spine, peripheral nerves, and the cranium.


supratentorial ependymoma

description: A high grade ependymoma that is located within the supratentorial brain.


name: adult central nervous system primitive neuroectodermal neoplasm

description: A central nervous system embryonal tumor, not otherwise specified that occurs in adults.


congenital epulis

description: A congenital gingival tumor that occurs along the alveolar ridge of the maxilla. It usually affects female infants. The histogenesis is unknown. Morphologically, it is characterized by the presence of large cells with eosinophilic granular cytoplasm. Complete surgical resection is curative.


giant cell glioblastoma

description: A rare histological variant of glioblastoma (WHO grade IV) with a predominance of bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin network, and a high frequency of TP53 mutations. (WHO)


pediatric supratentorial ependymoma

description: An ependymoma that arises from the supratentorial region of the brain and occurs during childhood.


childhood cerebral astrocytoma

description: An astrocytoma, without designation of benign or malignant, that is found in the supratentorial region. The infratentorial location is more common in children.


fibrillary astrocytoma

description: The most frequent histological variant of diffuse astrocytoma. It is predominantly composed of fibrillary neoplastic astrocytes. Nuclear atypia is a diagnostic criterion but mitotic activity, necrosis and microvascular proliferation are absent. The occasional or regional occurrence of gemistocytic neoplastic cells is compatible with the diagnosis of fibrillary astrocytoma. (WHO)


neurilemmoma of the pleura

description: A schwannoma that involves the pleura.


name: malignant glandular tumor of peripheral nerve sheath

description: A variant of malignant peripheral nerve sheath tumor characterized by the presence of glandular epithelium.


adult astrocytic tumor

description: An astrocytic tumor occurring during adulthood. Representative examples include diffuse astrocytoma, anaplastic astrocytoma, and glioblastoma.


childhood oligodendroglioma

description: An oligodendroglioma that arises from the central nervous system and occurs during childhood.


granular cell tumor

description: An unusual benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. It was originally thought to be a tumor originating from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells. It affects females more often than males and it usually presents as a solitary mass. A minority of patients have multiple tumors. It can arise from many anatomic sites including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast.


gliosarcoma

description: A rare histological variant of glioblastoma (WHO grade IV) characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation (WHO).


schwannoma of jugular foramen

description: A rare intracranial schwannoma that affects the jugular foramen.


brain astrocytoma

description: A astrocytoma (excluding glioblastoma) that involves the brain.


name: structural maintenance of chromosomes protein 5 isoform 1 (human)

description: A structural maintenance of chromosomes protein 5 isoform 1 that is encoded in the genome of human.


glycophorin-A O-glycosylated 9 (human)

A glycophorin-A (human) that has been O-glycosylated at the residue equivalent to Ser-21 of the amino acid sequence represented by UniProtKB:P02724-1, in which the glycan structure is represented by GlyTouCan:G65562ZE. Example: UniProtKB:P02724-1, Ser-21, MOD:00002~GNO:G65562ZE.


positive regulation of hippo signaling

description: Any process that activates or increases the frequency, rate or extent of hippo signaling.


name: glutaminase kidney isoform, mitochondrial isoform 2 (mouse)

description: A glutaminase kidney isoform, mitochondrial isoform 2 that is encoded in the genome of mouse.


name: glutaminase kidney isoform, mitochondrial isoform 2

description: A glutaminase kidney isoform, mitochondrial that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:D3Z7P3-2 or a 1:1 ortholog thereof.


name: glutaminase kidney isoform, mitochondrial isoform 2 (rat)

description: A glutaminase kidney isoform, mitochondrial isoform 2 that is encoded in the genome of rat.


disulfide

Compounds of structure RSSR'.


An organic disulfide obtained by oxidative dimerisation of 1-sulfanylnaphthalen-2-ol.


omega-conotoxin GVIA

A heterodetic cyclic polypeptide consisting of the linear sequence Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 with three disulfide bridges between cysteine residues 1-16, 8-19 and 15-26. Isolated from the venom of the fish-hunting snail Conus geographus.


An oligosaccharide derivative consisting of two [2-acetamido-4-amino-2,4-dideoxy-alpha-D-fucosyl-(1->4)-[beta-D-galactofuranosyl-(1->3)]-2-acetamido-2-deoxy-alpha-D-galactosyl-(1->3)-4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactosyloxy branched tetrasaccharide units linked via a dithiodihexyl divalent group. One of a panel of synthetic oligosaccharide derivatives designed to reveal a critical role of the rare aminosugar 2-acetamido-4-amino-2,4-dideoxy-D-fucose (2-acetamido-4-amino-2,4,6-trideoxy-D-galactose; D-AAT) for serotype 1 immune recognition (PMID:29632881).


name: glutathione amide disulfide dizwitterion

description: Dizwitterionic form of glutathione amide disulfide having both carboxy groups in anionic form and both amino groups protonated; major species at pH 7.3.


L-cystine mono-2-naphthylamide

An L-cysteine derivative that is the amide obtained by formal condensation of one of the carboxy groups of L-cystine with the amino group of 2-naphthylamine.


desirudin

A heterodetic cyclic peptide composed of 65 amino acids joined in sequence and cyclised by three disulfide bridges between cysteine residues 6-14, 16-28 and 22-39. It is a highly specific inhibitor of thrombin and used as an anticoagulant in patients to prevent venous thromboembolism. Its amino acid sequence differs from natural hirudin by lack of sulfate group on Tyr-63.


A pyridine alkaloid that is pyridine N-oxide substituted by a methyldisulfanyl group at position 2. Isolated from Allium stipitatum, it exhibits antibacterial activity.


A cholesteryl 6-O-acyl-beta-D-galactoside having 15-(ethyldisulfanyl)pentadecanoyl as the 6-O-acyl group.


GLIOTOXIN

A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.


An oligosaccharide derivative consisting of two 2-acetamido-4-amino-2,4-dideoxy-alpha-D-fucosyloxy ((2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-galactosyl) monosaccharide units linked via a dithiodihexyl divalent group. One of a panel of synthetic oligosaccharide derivatives designed to reveal a critical role of the rare aminosugar 2-acetamido-4-amino-2,4-dideoxy-D-fucose (2-acetamido-4-amino-2,4,6-trideoxy-D-galactose; D-AAT) for serotype 1 immune recognition (PMID:29632881).


allyl methyl disulfide

An  organic disulfide having allyl and methyl as the two organic groups.


GCB

An organic disulfide that is L-685,458 in which the C-terminal amide group is coupled to a biotin moiety via a long linker containing the disulfide group.


A beta-D-galactoside comprising methyl beta-D-galactoside having a 15-(ethyldisulfanyl)pentadecanoyl group attached at the 6-position.


D-penicillamine disulfide

An organic disulfide consisting of two D-penicillamines joined by a disulfide bond.


inorganic disulfide

Compounds of structure RSSR' in which R and R' are inorganic groups.


aldrithiol

A member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols.


ROSTRATIN D

An organic disulfide isolated from the whole broth of the marine-derived fungus Exserohilum rostratum and has been shown to exhibit antineoplastic activity.


An oligosaccharide derivative consisting of two 2-acetamido-4-amino-2,4-dideoxy-alpha-D-fucosyl-(1->4)-alpha-D-galacturonosyl-(1->3)-alpha-D-galacturonosyloxy trisaccharide units linked via a dithiodiethyl divalent group. One of a panel of synthetic oligosaccharide derivatives designed to reveal a critical role of the rare aminosugar 2-acetamido-4-amino-2,4-dideoxy-D-fucose (2-acetamido-4-amino-2,4,6-trideoxy-D-galactose; D-AAT) for serotype 1 immune recognition (PMID:29632881).


glionitrin A

A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring. It is an antibiotic isolated from the microbial strains Sphingomonas and Aspergillus fumigatus, and exhibits cytotoxic activity against four human cancer cell lines: HCT-116, A549, AGS, and DU145.


D-cystine

The D-enantiomer of cystine.


eptifibatide

A synthetic homodetic cyclic peptide comprising N(alpha)-(3-sulfanylpropanoyl)homoarginyl, glycyl, aspartyl, tryptophyl, prolyl and cysteinamide residues connected in sequence and cyclised via a disulfide bond. Derived from a protein found in the venom of the southeastern pygmy rattlesnake, Sistrurus miliarus barbouri, eptifibatide is an anti-coagulant that inhibits platelet aggregation by selectively blocking the platelet glycoprotein IIb/IIIa receptor, so preventing the binding of fibrinogen, von Willebrand factor, and other adhesive ligands. It is used in the management of unstable angina and in patients undergoing coronary angioplasty and stenting procedures.


An organic disulfide composed of two molecules of 2-{[2-(1H-indol-3-yl)ethyl]amino}ethane-1-thiol linked together via a disulfide bond. It is a glucose-6-phosphate dehydrogenase (G6PD) activator which reduces oxidative stress in cells and zebrafish.


A member of the class of furans that is disulfane in which both hydrogen's are substituted by 2-methylfuran-3-yl groups. It is a flavouring agent found in meat.


tropodithietic acid

A monocarboxylic acid that is 8,9-dithiabicyclo[5.2.0]nona-1,3,6-triene substituted by a carboxy group at position 2 and an oxo group at position 3. It is a broad spectrum antibiotic produced by the marine bacterium Phaeobacter inhibens that also acts as a signalling molecule at lower concentrations.


CYSTAMINE

An organic disulfide obtgained by oxidative dimerisation of cysteamine.


An oligosaccharide derivative consisting of two alpha-D-galacturonosyloxy monosaccharide units linked via a dithiodihexyl divalent group. One of a panel of synthetic oligosaccharide derivatives designed to reveal a critical role of the rare aminosugar 2-acetamido-4-amino-2,4-dideoxy-D-fucose (2-acetamido-4-amino-2,4,6-trideoxy-D-galactose; D-AAT) for serotype 1 immune recognition (PMID:29632881).


A member of the class of  dihydrofurans that is disulfane in which both hydrogen's are substituted by 2-methyl-4,5-dihydrofuran-3-yl groups. It is a flavouring agent found in meat.


ARANOTIN

An organic heterohexacyclic compound with antiviral and antibiotic properties that is isolated from Amauroascus aureus.


DIALLYLDISULFIDE

An organic disulfide where the organic group specified is allyl. It has been isolated from garlic and other species of the genus Allium.


An oligosaccharide derivative consisting of two 4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactosyloxy monosaccharide units linked via a dithiodihexyl divalent group. One of a panel of synthetic oligosaccharide derivatives designed to reveal a critical role of the rare aminosugar 2-acetamido-4-amino-2,4-dideoxy-D-fucose (2-acetamido-4-amino-2,4,6-trideoxy-D-galactose; D-AAT) for serotype 1 immune recognition (PMID:29632881).


lepirudin

A heterodetic cyclic peptide composed of 65 amino acids joined in sequence and cyclised by three disulfide bridges between cysteine residues 6-14, 16-28 and 22-39. It is a highly specific inhibitor of thrombin and used as an anticoagulant in patients with heparin-induced thrombocytopenia.


L,L-homocystine

A homocystine in which both chiral centres have L configuration.


pantethine

An organic disulfide that consists of two molecules of pantothenic acid linked by amide bonds to a cysteamine disulfide bridging group.


somocystinamide A

An organic disulfide that results from the dimerization of (10E,12R)-12-(acetylamino)-N-methyl-N-[(1E)-penta-1,4-dien-1-yl]-13-sulfanyltridec-10-enamide. Isolated from Lyngbya majuscula and Schizothrix, it exhibits antineoplastic acitivity.


sporidesmin A

An organic heteropentacyclic compound that has formula C18H20ClN3O6S2, produced by the saprophyte fungus Pithomyces chartarum. It is a mycotoxin responsible for the hepatogenous photosensitisation disease facial eczema in ruminants.


L-cystine di-2-naphthylamide

An L-cysteine derivative that is the amide obtained by formal condensation of the carboxy groups of L-cystine with the amino groups from two molecules of 2-naphthylamine.


CoA-glutathione

An organic disulfide arising from oxidative coupling of the thiol functions of coenzyme A and glutathione.


romidepsin

A cyclodepsipeptide consisting of the cyclic disulfide of (2Z)-2-aminobut-2-enoyl, L-valyl, (3S,4E)-3-hydroxy-7-sulfanylhept-4-enoyl, D-valyl and D-cysteinyl residues coupled in sequence and cyclised head-to tail.


Cys-Gly disulfide

An organic disulfide obtained by the oxidation of two Cys-Gly molecules which are then linked via a disulfide bond.


dimethyl disulfide

An organic disulfide that is methane in which one of the hydrogens has been replaced by a methyldisulfanyl group.


thiram

An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.


chetomin

An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity.


ROSTRATIN B

An organic disulfide isolated from the whole broth of the marine-derived fungus Exserohilum rostratum and has been shown to exhibit antineoplastic activity.


A member of the class of dithianes that is 1,2-dithiane substituted at positions 4 and 5 by trimethylsilyloxy groups.


CoA-disulfide

An organic disulfide obtained via oxidative dimerisation of coenzyme A.


lehualide K

An organic disulfide that is didecyl disulfide in which the hydrogens of the terminal methyl groups are replaced by 3,4-dimethoxy-5-methyl-2H-pyran-2-ones groups respectively. It has been isolated from the marine sponge of the genus Plakortis.


organic disulfide

Compounds of structure RSSR in which R and R' are organic groups.


R'C(R)S-S(R)CR'

Any disulfide with structure R'C(R)S-S(R)CR' in which R and R' can be =S or =O, or a variety of other groups.


An organic disulfide that is mitomycin C in which the amino group at position 7 is replaced by a {2-[(4-nitrophenyl)disulfanyl]ethyl}amino group. It is a derivative of mitomycin C with activity against a range of tumour cell lines and xenografts.


The cyclic form of dithioerythritol.


trypanothione disulfide

An organic disulfide resulting from the formal oxidative coupling of the thiol groups of N(1),N(8)-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata.


dipropyl disulfide

An organic disulfide where the alkyl groups specified are propyl. It is a component of the essential oils obtained from Allium.


bis(2-methylundecan-2-yl) disulfide

An organic disulfide that results from the formal oxidative dimerisation of 2-methylundecane-2-thiol.


4,4'-disulfanyldibutanoic acid

An organic disulfide resulting from the formal oxidative dimerisation of 4-sulfanylbutanoic acid.


L-cysteine glutathione disulfide

An organic disulfide that is the L-cysteinyl derivative of glutathione.


ROSTRATIN A

An organic disulfide  isolated from the whole broth of the marine-derived fungus Exserohilum rostratum and has been shown to exhibit antineoplastic activity.


spiruchostatin B

A spiruchostatin with molecular formula C21H33N3O6S2 originally isolated from a Pseudomonas culture broth.


4,4'-dipyridyl disulfide

An organic disulfide obtained by formal oxidative dimerisation of 4-thiopyridine.


A beta-D-galactoside comprising phenyl beta-D-galactoside having a 15-(ethyldisulfanyl)pentadecanoyl group attached at the 6-position.


homocystine

An organic disulfide obtained by oxidative dimerisation of homocysteine.


homocystines

A non-proteinogenic alpha-amino acid obtained by oxidative dimerisation of homocysteine and its derivatives.


glutathione amide disulfide

The disulfide arising by oxidative dimerisation of glutathione amide.


DIBENZYL DISULFIDE

An organic disulfide that results from the formal oxidative dimerisation of benzyl thiol.


BENZOTHIAZYL DISULFIDE

An organic disulfide resulting from the formal oxidative coupling of the thiol groups of two molecules of 1,3-benzothiazole-2-thiol. It is used as an accelerator in the rubber industry.


dithionitrobenzoic acid

An organic disulfide that results from the formal oxidative dimerisation of 2-nitro-5-thiobenzoic acid. An indicator used to quantify the number or concentration of thiol groups.


captopril disulfide

An organic disulfide in which the disulfide bond links two units of captopril. It is a secondary metabolite of captopril.


D-2-aminoadipic acid

An optically active form of 2-aminoadipic acid having D-configuration.


octopamine signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals generated as a consequence of octopamine binding to a cell surface receptor.


name: octopamine or tyramine signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by octopamine or tyramine binding to their receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription, and ending with the regulation of a downstream cellular process. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters.


name: octopamine signaling pathway involved in response to food

description: The series of molecular signals initiated by binding of octopamine to a receptor on the surface of the target cell that contributes to a response to a food stimulus.


name: positive regulation of fatty acid beta-oxidation by octopamine signaling pathway

description: An octopamine signaling pathway that results in positive regulation of fatty acid beta-oxidation.


tyramine signaling pathway

description: The series of molecular signals generated as a consequence of tyramine binding to a cell surface receptor.


name: KCNC3_HUMAN Potassium voltage-gated channel subfamily C member 3 (sprot)

description: A voltage-gated potassium channel KCNC3 that is encoded in the genome of human.


name: proteasome subunit alpha type-7 phosphorylated 1 (human)

description: A proteasome subunit alpha type-7 (human) that has been phosphorylated on the residue at the position equivalent to Ser-11 of the amino acid sequence represented by UniProtKB:O14818-1. Example: UniProtKB:O14818-1, Ser-11, MOD:00046.


name: thiamine pyrophosphokinase 1 isoform 2 (Arabidopsis thaliana)

description: A thiamine pyrophosphokinase 1 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:B9DGU7-2.


A thiamine-triphosphatase that is encoded in the genome of rat.


thiamine-triphosphatase isoform 1 (rat)

A thiamine-triphosphatase isoform 1 that is encoded in the genome of rat.


neuron navigator 1 isoform m4 (mouse)

A neuron navigator 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CH77-4.


NAV1_MOUSE Neuron navigator 1 (sprot)

A neuron navigator 1 that is encoded in the genome of mouse.


neuron navigator 1 isoform m1 (mouse)

A neuron navigator 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CH77-1.


neuron navigator 1 isoform m2 (mouse)

A neuron navigator 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CH77-2.


neuron navigator 1 isoform m3 (mouse)

A neuron navigator 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CH77-3.


name: activating signal cointegrator 1 isoform m2 (mouse)

description: An activating signal cointegrator 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QXN3-2.


activating signal cointegrator 1

A protein that is a translation product of the human TRIP4 gene or a 1:1 ortholog thereof.


name: activating signal cointegrator 1, initiator methionine removed form

description: An activating signal cointegrator 1 that has had the initiator methionine removed.


name: TRIP4_MOUSE Activating signal cointegrator 1 (sprot)

description: An activating signal cointegrator 1 that is encoded in the genome of mouse.


name: TRIP4_HUMAN Activating signal cointegrator 1 (sprot)

description: An activating signal cointegrator 1 that is encoded in the genome of human.


name: activating signal cointegrator 1 isoform 1 (mouse)

description: An activating signal cointegrator 1 isoform 1 that is encoded in the genome of mouse.


name: activating signal cointegrator 1 isoform 1

description: An activating signal cointegrator 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15650-1 or a 1:1 ortholog thereof.


name: activating signal cointegrator 1 deaminated 1 (human)

description: An activating signal cointegrator 1 (human) that has been deaminated on the residue at the position equivalent to Gln-425 of the amino acid sequence represented by UniProtKB:Q15650. UniProtKB:Q15650, Gln-425, MOD:00685.


name: activating signal cointegrator 1 glutathionylated 1 (human)

description: An activating signal cointegrator 1 (human) that has been glutathionylated on the residue at the position equivalent to Cys-86 of the amino acid sequence represented by UniProtKB:Q15650. UniProtKB:Q15650, Cys-86, MOD:00234.


name: activating signal cointegrator 1 isoform 1 (human)

description: An activating signal cointegrator 1 isoform 1 that is encoded in the genome of human.


name: Q9SN77_ARATH Transcription regulator/ zinc ion binding protein (trembl)

description: An activating signal cointegrator 1 that is encoded in the genome of Arabidopsis thaliana.


name: Q55CV3_DICDI GH84 domain-containing protein (trembl)

description: An activating signal cointegrator 1 that is encoded in the genome of Dictyostelium discoideum.


name: glycine--tRNA ligase isoform A (fruit fly)

description: A glycine--tRNA ligase (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9VUK8-2.


name: DBF4B_HUMAN Protein DBF4 homolog B (sprot)

description: A protein DBF4 homolog B that is encoded in the genome of human.


protein DBF4 homolog B

A protein that is a translation product of the human DBF4B gene or a 1:1 ortholog thereof.


name: protein DBF4 homolog B isoform h2 (human)

description: A protein DBF4 homolog B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NFT6-2.


name: protein DBF4 homolog B isoform h3 (human)

description: A protein DBF4 homolog B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NFT6-3.


name: protein DBF4 homolog B isoform h4 (human)

description: A protein DBF4 homolog B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NFT6-4.


name: protein DBF4 homolog B isoform h1 (human)

description: A protein DBF4 homolog B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NFT6-1.


name: 5-chloro-4-[[3-(3,4-dimethoxyphenyl)-1-oxoprop-2-enyl]amino]-2-methoxybenzoic acid methyl ester


H2B3A_MOUSE H2B.U histone 2 (sprot)

An H2B.U histone 2 that is encoded in the genome of mouse.


Q9FHX6_ARATH Dbj (trembl)

A protein GPR107 that is encoded in the genome of Arabidopsis thaliana.


name: U76C3_ARATH UDP-glycosyltransferase 76C3 (sprot)

description: A protein that is a translation product of the UGT76C3 gene in Arabidopsis thaliana.


A naphthylmethanol that is methanol in which one of the hydrogens of the methyl group is replaced by a naphthalen-1-yl group.


naphthylmethanol

A primary alcohol that is methanol in which one of the methyl hydrogens has been replaced by a naphthyl or a substituted naphthyl group.


A naphthylmethanol that is methanol in which one of the methyl hydrogens has been replaced by a (2-naphthyl) group.


name: INS1A_DANRE Insulinoma-associated protein 1a (sprot)

description: An insulinoma-associated protein 1 that is encoded in the genome of zebrafish.


insulinoma-associated protein 1

A protein that is a translation product of the human INSM1 gene or a 1:1 ortholog thereof.


name: INSM1_MOUSE Insulinoma-associated protein 1 (sprot)

description: An insulinoma-associated protein 1 that is encoded in the genome of mouse.


name: RL10A_RAT Large ribosomal subunit protein uL1 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL1 that is encoded in the genome of rat.


name: XIAP-associated factor 1 isoform m2 (mouse)

description: An XIAP-associated factor 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5NBU8-3.


Recurrent Lung Neuroendocrine Neoplasm

description: The reemergence of a lung neuroendocrine neoplasm after a period of remission.


name: TPST1_HUMAN Protein-tyrosine sulfotransferase 1 (sprot)

description: A protein-tyrosine sulfotransferase 1 that is encoded in the genome of human.


name: protein-tyrosine sulfotransferase 1 isoform 1 (human)

description: A protein-tyrosine sulfotransferase 1 isoform 1 that is encoded in the genome of human.


name: RNA polymerase-associated protein RapA, initiator methionine removed form

description: An RNA polymerase-associated protein RapA that has had the initiator methionine removed.


name: MXI1_DANRE Max-interacting protein 1 (sprot)

description: A max-interacting protein 1 that is encoded in the genome of zebrafish.


estrogen receptor signaling pathway

description: A nuclear receptor-mediated signaling pathway initiated by an estrogen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


name: vascular cell adhesion protein 1 O-glycosylated 3 (human)

description: A vascular cell adhesion protein 1 (human) that has been O-glycosylated at the residue equivalent to Thr-81 of the amino acid sequence represented by UniProtKB:P19320-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P19320-1, Thr-81, MOD:00005~GNO:G43417UB.


name: lysosomal-associated transmembrane protein 4B isoform 1 (rat)

description: A lysosomal-associated transmembrane protein 4B isoform 1 that is encoded in the genome of rat.


name: lysosomal-associated transmembrane protein 4B isoform 1

description: A lysosomal-associated transmembrane protein 4B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91XQ6-1 or a 1:1 ortholog thereof.


name: lysosomal-associated transmembrane protein 4B isoform 1 (mouse)

description: A lysosomal-associated transmembrane protein 4B isoform 1 that is encoded in the genome of mouse.


An O-(S-acylpantetheine-4'-phosphoryl)serine(1-) residue in which the S-acyl group is specified as (3R)-hydroxy-4-methylhexanoyl.


selenophene

A five-membered monocyclic heteroarene composed of four CH units and one selenium atom. The parent of the class of selenophenes.


A macromolecule composed of repeating selenophenyl units connected at the 2- and 5-positions.


benign testicular sertoli cell tumor

description: A non-metastasizing sex cord-stromal tumor that arises from the testis. Morphologically, it is characterized by the presence of Sertoli cells forming tubules. Leydig cells are rare or absent.


testicular sertoli cell tumor

description: A sex cord-stromal tumor that arises from the testis and is characterized by the presence of neoplastic cells with features of Sertoli cells. It usually presents as a slow growing testicular mass. The vast majority of cases follow a benign clinical course.


claudin-5 isoform 1 (human)

A claudin-5 isoform 1 that is encoded in the genome of human.


A protein that is a translation product of the human CLDN5 gene or a 1:1 ortholog thereof.


claudin-5 isoform 1 (mouse)

A claudin-5 isoform 1 that is encoded in the genome of mouse.


CLD5_MOUSE Claudin-5 (sprot)

A claudin-5 that is encoded in the genome of mouse.


CLD5_RAT Claudin-5 (sprot)

A claudin-5 that is encoded in the genome of rat.


claudin-5 isoform 1

A claudin-5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00501-1 or a 1:1 ortholog thereof.


claudin-5 isoform 1 (rat)

A claudin-5 isoform 1 that is encoded in the genome of rat.


Refractory Childhood Lymphoma

description: Childhood Hodgkin or non-Hodgkin lymphoma that is resistant to treatment.


Refractory Childhood Hodgkin Lymphoma

description: Hodgkin lymphoma that occurs during childhood and is resistant to treatment.


name: CSRP2_CHICK Cysteine and glycine-rich protein 2 (sprot)

description: A cysteine and glycine-rich protein 2 that is encoded in the genome of chicken.


delta-sarcoglycan

A protein that is a translation product of the human SGCD gene or a 1:1 ortholog thereof.


SGCD_MOUSE Delta-sarcoglycan (sprot)

A delta-sarcoglycan that is encoded in the genome of mouse.


delta-sarcoglycan isoform h2 (human)

A delta-sarcoglycan (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92629-2.


delta-sarcoglycan isoform 1 (mouse)

A delta-sarcoglycan isoform 1 that is encoded in the genome of mouse.


SGCD_HUMAN Delta-sarcoglycan (sprot)

A delta-sarcoglycan that is encoded in the genome of human.


delta-sarcoglycan isoform 1

A delta-sarcoglycan that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92629-1 or a 1:1 ortholog thereof.


delta-sarcoglycan isoform h3 (human)

A delta-sarcoglycan (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92629-3.


delta-sarcoglycan isoform 1 (human)

A delta-sarcoglycan isoform 1 that is encoded in the genome of human.


name: serine/threonine-protein kinase receptor R3 sequence variant L285F (human)

description: A serine/threonine-protein kinase receptor R3 (human) that has a Phe residue at the position equivalent to Leu-285 of the amino acid sequence represented by UniProtKB:P37023. UniProtKB:P37023, Leu-285, CHEBI:29997.


Sarcoma GX

description: A sarcoma in which the grade cannot be evaluated.


name: ferredoxin-2, mitochondrial, transit peptide removed form (human)

description: A ferredoxin-2, mitochondrial (human) that has had the transit peptide removed. UniProtKB:Q6P4F2, 56-186.


name: FDX2_HUMAN Ferredoxin-2, mitochondrial (sprot)

description: A ferredoxin-2, mitochondrial that is encoded in the genome of human.


name: ferredoxin-2, mitochondrial isoform h2 (human)

description: A ferredoxin-2, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6P4F2-2.


name: ferredoxin-2, mitochondrial isoform h1 (human)

description: A ferredoxin-2, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6P4F2-1.


protein SOX-15 isoform h1 (human)

A protein SOX-15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60248-1.


name: PEBP2_MOUSE Phosphatidylethanolamine-binding protein 2 (sprot)

description: A phosphatidylethanolamine-binding protein 2 that is encoded in the genome of mouse.


A protein that is a translation product of the mouse Pbp2 gene or a 1:1 ortholog thereof.


name: phosphatidylethanolamine-binding protein 2 isoform m2 (mouse)

description: A phosphatidylethanolamine-binding protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8VIN1-2.


name: phosphatidylethanolamine-binding protein 2 isoform m1 (mouse)

description: A phosphatidylethanolamine-binding protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8VIN1-1.


name: ERM_DROME Fez family zinc finger protein erm (sprot)

description: A protein that is a translation product of the erm gene in fruit fly.


name: DPOE4_DROME DNA polymerase epsilon subunit 4 (sprot)

description: A protein that is a translation product of the PolE4 gene in fruit fly.


cyclobenzaprine

5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its hydrochloride salt in the symptomatic treatment of painful muscle spasm.


name: RNA-binding protein FXR1 isoform A (human)

description: An RNA-binding protein FXR1 isoform A that is encoded in the genome of human.


name: tryptophan--tRNA ligase, cytoplasmic, initiator methionine removed form

description: A tryptophan--tRNA ligase, cytoplasmic that has had the initiator methionine removed.


name: tryptophan--tRNA ligase, cytoplasmic, initiator methionine removed form (human)

description: A tryptophan--tRNA ligase, cytoplasmic (human) that has had the initiator methionine removed. UniProtKB:P23381, 2-471.


UDP-D-apiose

A UDP-sugar having D-apiose as the sugar portion.


UDP-alpha-D-apiose

A UDP-D-apiose in which the anomeric centre of the apiose fragment has alpha-configuration.


name: UDP-glucose:glycoprotein glucosyltransferase 1 deaminated 2 (human)

description: A UDP-glucose:glycoprotein glucosyltransferase 1 (human) that has been deaminated on the residue at the position equivalent to Gln-1210 of the amino acid sequence represented by UniProtKB:Q9NYU2-1. Example: UniProtKB:Q9NYU2-1, Gln-1210, MOD:00685.


name: UGGG1_HUMAN UDP-glucose:glycoprotein glucosyltransferase 1 (sprot)

description: A UDP-glucose:glycoprotein glucosyltransferase 1 that is encoded in the genome of human.


name: UDP-glucose:glycoprotein glucosyltransferase 1, signal peptide removed form (human)

description: A UDP-glucose:glycoprotein glucosyltransferase 1 (human) that has had the signal peptide removed. UniProtKB:Q9NYU2, 43-1555.


name: UDP-glucose:glycoprotein glucosyltransferase 1 hydroxylated 1 (human)

description: A UDP-glucose:glycoprotein glucosyltransferase 1 (human) that has been hydroxylated on the residue at the position equivalent to Pro-1088 of the amino acid sequence represented by UniProtKB:Q9NYU2-1. Example: UniProtKB:Q9NYU2-1, Pro-1088, MOD:00678.


name: UDP-glucose:glycoprotein glucosyltransferase 1 isoform h2 (human)

description: A UDP-glucose:glycoprotein glucosyltransferase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NYU2-2.


name: UDP-glucose:glycoprotein glucosyltransferase 1 acetylated 1 (human)

description: A UDP-glucose:glycoprotein glucosyltransferase 1 (human) that has been acetylated on the residue at the position equivalent to Lys-1211 of the amino acid sequence represented by UniProtKB:Q9NYU2-1. Example: UniProtKB:Q9NYU2-1, Lys-1211, MOD:00723.


name: UDP-glucose:glycoprotein glucosyltransferase 1 deaminated 3 (human)

description: A UDP-glucose:glycoprotein glucosyltransferase 1 (human) that has been deaminated on the residue at the position equivalent to Gln-809 of the amino acid sequence represented by UniProtKB:Q9NYU2-1. Example: UniProtKB:Q9NYU2-1, Gln-809, MOD:00685.


name: UDP-glucose:glycoprotein glucosyltransferase 1 deaminated 1 (human)

description: A UDP-glucose:glycoprotein glucosyltransferase 1 (human) that has been deaminated on the residue at the position equivalent to Gln-1243 of the amino acid sequence represented by UniProtKB:Q9NYU2-1. Example: UniProtKB:Q9NYU2-1, Gln-1243, MOD:00685.


name: UDP-glucose:glycoprotein glucosyltransferase 1 isoform h1 (human)

description: A UDP-glucose:glycoprotein glucosyltransferase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NYU2-1.


name: developmental and epileptic encephalopathy, 86


name: C-type lectin domain family 5 member A isoform m1 (mouse)

description: A C-type lectin domain family 5 member A (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9R007-1.


A polysaccharide derivative with a repeating unit consisting of beta-D-galactosyl, beta-D-rhamnoosyl and beta-D-glucosyl residues all linked (1->4), to the galactosyl residue of which is attached an N-acetyl-alpha-neuraminyl-(2->6)-N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl trisaccharide unit via a (1->3) linkage, while to the rhamnosyl residue is linked (1->3) an alpha-D-galactosyl residue, with all repeating units being linked (1->4). Capsular polysaccharide of Streptococcus suis serotype 1/2.


name: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein methylated 3 (human)

description: A phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (human) that has been methylated on the residue at the position equivalent to Cys-1572 of the amino acid sequence represented by UniProtKB:Q8TCU6-1. Example: UniProtKB:Q8TCU6-1, Cys-1572, MOD:00660.


name: exosome complex component 10 isoform h1 (human)

description: An exosome complex component 10 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q01780-1.


name: HB2D_RAT Rano class II histocompatibility antigen, D-1 beta chain (sprot)

description: A protein that is a translation product of the RT1-Db1 gene in rat.


Tuberculous bronchopneumonia

description: Acute and progressive bronchopneumonia caused by Mycobacterium tuberculosis bacteria.  It is characterized by widespread pulmonary patchy consolidations.


name: equatorial microtubule organizing center disassembly

description: The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis.


Advanced HER2-Low Breast Carcinoma

description: A HER2-low breast adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: DNA replication complex GINS protein PSF3 isoform 1 (human)

description: A DNA replication complex GINS protein PSF3 isoform 1 that is encoded in the genome of human.


name: DNA replication complex GINS protein PSF3 isoform h3 (human)

description: A DNA replication complex GINS protein PSF3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BRX5-3.


name: DNA replication complex GINS protein PSF3 isoform h2 (human)

description: A DNA replication complex GINS protein PSF3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BRX5-2.