carprofen

Propanoic acid in which one of the methylene hydrogens is substituted by a 6-chloro-9H-carbazol-2-yl group. A non-steroidal anti-inflammatory drug, it is no longer used in human medicine but is still used for treatment of arthritis in elderly dogs.


azepinoindole

Any organic heterotricyclic compound with a skeleton consisting of an azepine ring fused to an indole.


acridine half-mustard

A member of the class of aminoacridines that is acridine which is substituted by a methoxy group at position 2, chlorine at position 6, and a {3-[(2-chloroethyl)amino]propyl}amino group at position 9.


A molybdopterin dinucleotide in which the other nucleobase is guanine and the coordinated molybdenum species is MoO2.


A terpene glycoside obtained by glycosylation of the 15-hydroxy group of 11,13-dihydro-8-deoxylactucin. Found in chicory.


molybdopterin

A molybdopterin that is the O-phospho derivative of [(5aR,8R,9aR)-2-amino-4-oxo-6,7-disulfanyl-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methanol.


achillin

A sesquiterpene lactone that is (3R,3aS,9aS,9bS)-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione carrying three additional methyl substituents at positions 3, 6 and 9.


PENICILLIDE

A dibenzodioxocine that is 5H,7H-dibenzo[b,g][1,5]dioxocin-5-one substituted by a hydroxy group at position 11, a (1S)-1-hydroxy-3-methylbutyl group at position 3 and a methoxy and a methyl group at positions 4 and 9 respectively. It is isolated from the culture broth of Penicillium asperosporum and acts as an acyl-CoA:cholesterol acyltransferase inhibitor.


(+)-corvol ether A

A tricyclic sesquiterpenoid with formula C15H26O which is biosynthesised from farnesyl diphosphate by a sesquiterpene cyclase enzyme from Kitasatospora setae.


An organic heterotricyclic compound that is metazocine in which the methyl group at the N-position is replaced by an allyl group.


fumisoquin C

An isoquinoline alkaloid produced by a biosynthetic gene cluster called fsq in the human pathogen Aspergillus fumigatus.


mosapramine

A racemate comprising equimolar amounts of (R)- and (S)-mosapramine. It is a second-generation antipsychotic used for the treatment of schizophrenia.


RUCAPARIB CAMSYLATE

A camphorsulfonate salt obtained by reaction of rucaparib with one molar equivalent of (1S,4R)-camphorsulfonic acid. It is an inhibitor of poly (ADP-ribose) polymerase and is used as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation.


A member of the class of phenazines that is 1,4,10,10a-tetrahydrophenazine substituted at position 1 by a carboxy group (the 1R,10aS-diastereomer).


benzoquinolizine

Any organic heterotricyclic compound with a skeleton consisting of a quinolizine fused to a benzene ring.


A furanocoumarin which bears a methoxy group at position 5.


rhizopycnolide A

A benzochromene that is benzo[c]chromen-6-one which is substituted by hydroxy groups at positions 1, 4 and 7, methoxy groups at positions 3 and 9, a methyl group at position 1, and a 2-carboxy-2-hydroxyethyl group at position 4, and in which the carboxy group has undergone condensation with the 4-hydroxy group to afford the corresponding spirocyclic lactone. It is active against the pathogenic bacteria Agrobacterium tumefaciens, Bacillus subtilis, Pseudomonas lachrymans, Ralstonia solanacearum, Staphylococcus hemolyticus, and Xanthomonas vesicatoria, with MIC values in the range 25-100 mug/mL.


dibenzodioxine

Oxanthrene (formerly dibenzo[b,e][1,4]dioxine) and its derivatives.


callophycoic acid D

A dibenzooxepine diterpenoid that is hexahydrodibenzo[b,e]oxepine-2-carboxylic acid with an isolated double bond between positions 6 and 6a and is substituted by a bromo, 2-[(1S,3S,6S)-3-bromo-6-hydroxy-2,2,6-trimethylcyclohexyl]ethyl and a methyl group at positions 9, 10 and 10 respectively (the 9S,10S,10aR stereoisomer). An isomer of callophycoic acid C, it is isolated from the Fijian red alga Callophycus serratus and exhibits antibacterial, antimalarial and anticancer activities.


CUDRAFLAVONE B

An extended flavonoid that consists of a pyranochromane skeleton that is 2H,6H-pyrano[3,2-g]chromen-6-one substituted by geminal methyl groups at position 2, a 2,4-dihydroxyphenyl group at position 8, a hydroxy group at position 5 and a prenyl group at position 7. Isolated from Morus alba and Morus species it exhibits anti-inflammatory activity.


A naphthoimidazole that is 1H-naphtho[2,3-d]imidazole-4,9-dione which is substituted at positions 1 by pyrazin-2-ylmethyl and methyl groups, respectively.


dipyridodiazepine

An organic heterotricyclic compound whose skeleton consists of a diazepine ring which is fused to two pyridine rings.


A furanocoumarin which bears a hydroxy group at position 5.


imipramine

A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.


A sesquiterpene lactone that is 3a,4,4a,5,6,7,7a,9a-octahydroazuleno[6,5-b]furan-2(3H)-one substituted by a hydroxy group at position 5, methyl groups at positions 5 and 8, a methylidene group at position 3 and an acetoxy group at position 4. It has been isolated from the aerial parts of Inula hupehensis.


leucosesterterpenone

A sesterterpenoid isolated from Leucosceptrum canum. It has been shown to exhibit anti-angiogenic and inhibitory activity against prolyl endopeptidase ( EC 3.4.21.26 ).


midazolam

An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.


loline alkaloid

A pyrrolizidine alkaloid that is hexahydro-1H-pyrrolizine carrying an exo-1-amino group at position 1 and an ether bridge between C-2 and C-7. It is a class of natural insecticides produced by fungal symbionts of Poaceae.


etrasimod

An organic heterotricyclic compound that is 1,2,3,4-tetrahydrocyclopenta[b]indole substituted by carboxymethyl and [4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy groups at positions 3R and 7, respectively. It is a potent and functional antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50 = 1.88 nM in CHO cells).


caseamemebrol B

A diterpenoid of the clerodane group isolated from the leaves and twigs of Casearia membranacea. It exhibits significant cytotoxicity against human prostrate (PC-3) cancer cells.


A member of the class of carbazoles that is 1,3-di(9H-carbazol-9-yl)propan-2-ol in which the hydroxy group is replaced by a 2-hydroxy-3-[(propan-2-yl)amino]propoxy group. It is a DNA methyltransferase 1 inhibitor (IC50 = 1.7 muM).


A flavin adenine dinucleotide that is FADH2 bearing an N-sulfo substituent at position 5 of the flavin ring system..


DIAZEPINOMICIN

A dibenzodiazepine with a farnesyl sidechain synthesized by Micromonospora sp.. It has a potent activity against a broad spectrum of tumor cell lines.


norrubrofusarin

A member of the class of benzochromenones that is 4H-benzo[g]chromen-4-one carrying a methyl group at position 2 and a hydroxy group at positions 5, 6 and 8, respectively.


tilimycin

A pyrrolobenzodiazepine that is (11aS)-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine which is substituted by an oxo group at position 5 and by hydroxy groups at positions 9 and 11. It is an enterotoxic natural product synthesized via a non-ribosomal peptide synthase in Klebsiella oxytoca.


phomacin C

A cytochalasin isolated from a fungus Phoma sp. that has been shown to possess potent inhibitory activity against HT-29 colonic adenocarcinoma cells.


An iminium ion resulting from the protonation of the two imine groups of beta-saxitoxinol; major microspecies at pH 7.3.


YTM-T

A member of the class of pyrroloindoles that is an intermediate in the biosynthesis of yatakemycin by Streptomyces sp. TP-A0356


ALPHA-HYDROXY-MIDAZOLAM

An imidazobenzodiazepine that is midazolam in which one of the hydrogens of the methyl group is substituted by a hydroxy group. It is the major metabolite of the anesthetic, midazolam.


A member of the class of dibenzofurans that is dibenzo[b,d]furan substituted by a chloro group at position 8 and hydroxy groups at position 2 and 7.


thymidine dimer

A nucleoside analogue obtained by formal cyclodimerisation of thymidine.


CASEANIGRESCEN D

A diterpenoid of the clerodane group isolated from the leaves and flowers of Casearia nigrescens. It exhibits cytotoxicity against A2780 human ovarian cancer cell line.


phytuberin

A sesquiterpenoid commonly found in potatoes.


(S)-tianeptine

The S-enantiomer of tianeptine.


SCHWEINFURTHIN H

A stilbenoid isolated from  Macaranga alnifolia and has been shwon to exhibit cytotoxic activity.


flavin

A derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position.


pyridobenzodiazepine

Any three-ring heterocyclic compound with a skeleton consisting of a pyridine ring ortho-fused to a benzodiazepine.


callophycoic acid C

A dibenzooxepine diterpenoid that is hexahydrodibenzo[b,e]oxepine-2-carboxylic acid with an isolated double bond between positions 6a and 7 and is substituted by a bromo, 2-[(1S,3S,6S)-3-bromo-6-hydroxy-2,2,6-trimethylcyclohexyl]ethyl and a methyl group at positions 9, 10 and 10 respectively (the 9S,10S,10aR stereoisomer). It is isolated from the Fijian red alga Callophycus serratus and exhibits antibacterial, antimalarial and anticancer activities.


promethazine

A  tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.


A naphtho-gamma-pyrone that is 3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one substituted by hydroxy groups at positions 3,6,7 and 9.


Any benzo[g]pteridine-2,4-dione that is 5,10-dihydrobenzo[g]pteridine-2,4(1H,3H)-dione which is substituted by methyl groups at positions 7 and 8 and is also substituted at position 10.


GUAIANOLIDE

A guaiane sesquiterpenoid with anti-inflammatory activity isolated from the aerial parts of Inula hupehensis.


(-)-homalomenol D

An organic heterotricyclic compound and sesquiterpenoid that is 11-oxatricyclo[5.3.1.0(2,6)]undecan-8-ol which is substituted by methyl groups at positions 2 and 8, and by an isopropyl group at position 5. The absolute stereochemistry is not known; it is either 1R,2R,5S,6S,7R,8R (as shown), or the enantiomer.


CHAETOCHROMIN D

A  biaryl that is 2,3-dihydro-4H,4'H-9,9'-bibenzo[g]chromene-4,4'-dione substituted by hydroxy groups at positions 5, 5', 6, 6', 8 and 8' and methyl groups at positions 2, 2', 3 and 3'. It has been isolated from Chaetomium gracile.


protopine

A dibenzazecine alkaloid isolated from Fumaria vaillantii.


alternariol hapten ALa

An alternariol hapten that is one of two regioisomeric haptens of the mycotoxin alternariol in which the five-atom carboxylated aliphatic spacer arm is located through the hydroxy group at C-9.


A flavin mononucleotide that is 8-amino-8-demethylriboflavin in which the hydroxy hydrogen at position 5' of the ribitol fragment has been replaced by a phosphono group.


ustilaginoidin G

A binaphthopyran resulting from the formal oxidative coupling at positions 9 of molecules of 5,6,8-trihydroxy-2-methyl-2,3-dihydro-4H-benzo[g]chromen-4-one and (6S)-5,6,8-(6S)-5,6,8-trihydroxy-2-methyl-6,9-dihydro-4H-benzo[g]chromen-4-one.


dibenzodiazepine

Any organic heterotricyclic compound with a skeleton consisting of two benzene rings fused to a diazepine ring.


A triazolobenzothiazole that is [1,2,4]triazolo[5,1-b][1,3]benzothiazole substituted at positions 1 and 2 by 4-methylbenzoyl and thioxo groups respectively.


1-hydroxymidazolam beta-D-glucuronide

A beta-D-glucosiduronic acid that is beta-D-glucuronic acid in which the anomeric hydroxyl hydrogen has been replaced by a 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-yl group. It is the glucuronidated conjugate of the midazolam metabolite, 1-hydroxymidazolam.


candelalide B

A diterpenoid isolated from Sesquicillium candelabrum and has been shown to act as a blocker of the voltage-gated potassium channel Kv1.3.


4'-epichaetoviridin F

An  azaphilone that is 6H-furo[2,3-h]isochromene-6,8(6aH)-dione substituted by a chloro group at position 5, a methyl group at position 6a, a 2-methylbutanoyl group at position 9 and a 3-methylpent-1-en-1-yl group at position 3. It has been isolated from Chaetomium globosum.


jacoline N-oxide

A pyrrolizine alkaloid that is jacoline in which the tertiary amino function has been oxidised to the corresponding N-oxide.


An iminium ion resulting from the protonation of the two imine groups of 11-beta-hydroxy-beta-saxitoxinol; major microspecies at pH 7.3.


ustilaginoidin B

A binaphthopyran resulting from the formal oxidative coupling at positions 9 of molecules of 5,6,8-trihydroxy-2-methyl-4H-benzo[g]chromen-4-one and 5,6,8-trihydroxy-2-(hydroxymethyl)-4H-benzo[g]chromen-4-one.


cleistanthin D

A member of the class of cleistanthins that is cleistanthin A in which the 3,4-di-O-methyl-D-xylopyranosyl group is replaced by a 2,3,4-tri-O-methyl-D-xylofuranosyl group.


ustilaginoidin I

A binaphthopyran resulting from the formal oxidative coupling at positions 9 of molecules of 5,6,8-trihydroxy-2-(hydroxymethyl)-2,3-dihydro-4H-benzo[g]chromen-4-one and (6S)-5,6,8-trihydroxy-2-methyl-6,9-dihydro-4H-benzo[g]chromen-4-one.


A labdane diterpenoid that is the 1,9-dideoxy derivative of forskolin.


paritaprevir

An azamacrocycle which is used which is in combination with dasabuvir sodium hydrate, ombitasvir and ritonavir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.


A member of the class of psoralens that is psoralen substituted by a methoxy group at position 4 and a [(2R)-3-butoxy-2-hydroxy-3-methylbutyl]oxy group at position 9. Isolated from the roots of Angelica dahurica, it exhibits inhibitory activity against COX-2 and 5-lipooxygenase.


MOLLICELLIN E

A member of the class of depsidones that is 11H-dibenzo[b,e][1,4]dioxepine substituted by a chloro group at position 2,  hydroxy groups at positions 3 and 9, a methoxy group at position 8, methyl groups at positions 1 and 6, a 3-methylbut-2-enoyl group at position 7, an oxo group at position 11 and a formyl group at position 4. Isolated from Chaetomium brasiliense, it exhibits antimalarial and cytotoxic activities.


pyrazoloquinoline

Any organic heterotricyclic compound that consists of a pyrazole ring ortho-fused to a quinoline.


orbiculin H

A dihydroagarofuran sesquiterpenoid that consists of dihydro-beta-agarofuran substituted by acetoxy groups at positions 1 and 8 and furoyloxy groups at positions 6 and 9 (the 1beta,8beta,6alpha,9alpha stereoisomer).  Isolated from Celastrus orbiculatus and exhibits inhibition of both NF-kappaB activation and nitric oxide production.


alcaftadine

An imidazobenzazepine that is 6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine substituted at position 3 by a formyl group and at position 11 by a 1-methylpiperidin-4-ylidene group. An antihistamine used for treatment of allergic conjunctivitis.


A member of the class of phenazines that is (5aS)-5,5a-dihydrophenazine substituted at positions 1 and 6 by carboxy groups.


REYNOSIN

A sesquiterpene lactone of the eudesmanolide group, found particularly in Magnolia grandiflora and Laurus nobilis.


(S)-propyromazine

A 1-methyl-1-[1-oxo-1-(10H-phenothiazin-10-yl)propan-2-yl]pyrrolidinium that has S-configuration.


(3aS,4S,9bR)-golgicide A

A 6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline that has 3aS,4S,9bR configuration.


molybdopterin synthase intermediate

An organic heterotricyclic compound consisting of a pyran ring fused to a pteridine ring system.


FUKANEFUROMARIN B

A furanocoumarin that is 2,3-dihydrofuro[3,2-c]coumarin substituted by a hydroxy group at position 7, methyl groups at positions 2 and 3 (relatively trans configuration) and a 4,8-dimethyl-4(E),7-nonadien-6-onyl moiety at position 2. Isolated from the roots of Ferula fukanensis, it inhibits production of nitric oxide (NO).


torin 2

A member of the class of pyridoquinolines that is benzo[h][1,6]naphthyridin-2-one carrying additional 3-(trifluoromethyl)phenyl and 6-aminopyridin-3-yl substituents at positions 1 and 9 respectively. It is a potent inhibitor of mTOR and exhibits anti-cancer properties.


A member of the class of cyclobutadipyrimidines that is hexahydro-1,3,6,8-tetraazabiphenylene-2,4,5,7-tetrone carrying two additional methyl substituents at positions 4a and 4b.


name: (S)-1,2-di-O-dodecanylglycero-3-glutaric acid 6'-methylresorufin ester

description: A diester obtained by formal condensation of the carboxy groups of glutaric acid with the hydroxy groups of (S)-1,2-di-O-dodecanylglycerol and 7-hydroxy-6-methylphenoxazin-3-one.


fumiquinazoline C

A fumiquinazoline obtained by oxidative spirocyclisation of fumiquinazoline A.


dibenzofurans

Any organic heterotricyclic compound based on a dibenzofuran skeleton and its substituted derivatives thereof.


5,10-dihydrophenazine-1-carboxylic acid

A member of the class of phenazines that is 5,10-dihydrophenazine substituted at position 1 by a carboxy group.


ARBUSCULIN A

A sesquiterpene lactone isolated from Saussureae Radix and has been shown to exhibit inhibitory activity against melanogenesis.


imidazoindole

Any organic heterotricyclic compound that consists of an imidazole ring ortho-fused to an indole.


MANZAMINE A

An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).


A member of the class of imidazopyrimidopyrimidines that is 5,6-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidine substituted by [4-(morpholin-4-yl)phenyl]amino, oxo and 2,6-dichlorophenyl groups at positions 2, 5 and 6, respectively. It is a potent inhibitor of Wee-1 kinase (Ki = <10 nM).


flupenthixol

A thioxanthene derivative having a trifluoromethyl substituent at the 2-position and a 3-(4-(2-hydroxyethyl)piperazin-1-yl)propylidene group at the 10-position with undefined double bond stereochemistry.


ODQ

A member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group.


(S)-profenamine

The (S)-enantiomer of profenamine.


carbazole alkaloid

Any alkaloid based on a carbazole skeleton.


naphtho-alpha-pyrone

Any naphthopyran whose skeleton consists of a naphathalene ring system ortho-fused to an alpha-pyrone.


prochlorperazine

A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.


A member of the class of thienotriazolodiazepines that is the methyl ester of [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid. A bromodomain and extra-terminal domain (BET)-specific inhibitor that belongs to a group of thienodiazepine-based compounds


A benzocycloheptapyridine that consists of 8-chloro-3-methyl-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine bearing a 1-(pyridin-4-ylacetyl)piperidin-4-ylidene group at position 11.


BODIPY R6G

A BODIPY dye having a phenyl substituent at the 5-position and a (2-carboxyethyl) substituent at the 3-position.


2'-deoxycytidine-thymidine dimer

A nucleoside analogue obtained by formal cyclodimerisation of 2'-deoxycytidine and thymidine.


filiforminol

A tricyclic sesquiterpenoid that is isolated from the Australian marine alga Laurencia filiformis.


CHIMONANTHINE

The (3aR,3a'R,8aR,8a'R)-stereoisomer of chimonanthine.


cylindrospermopsins

A class of organic heterotricyclic compounds that consists of cylindrospermopsin and its structural analogues.


orbiculin F

A dihydroagarofuran sesquiterpenoid that consists of dihydro-beta-agarofuran substituted by acetoxy group at position 1, benzoyloxy group at position 9 and furoyloxy groups at positions 2 and 6 (the 1beta,9alpha,2beta,6alpha stereoisomer). Isolated from Celastrus orbiculatus, it exhibits inhibition of both NF-kappaB activation and nitric oxide production.


cordysinin D

A member of the class of beta-carbolines that is beta-carboline substituted by a 1-hydroxyethyl group at position 1 (the S enantiomer). It has been isolated from the mycelia of Cordyceps sinensis.


ACRIDONE

A member of the class of  acridines that is 9,10-dihydroacridine substituted by an oxo group at position 9.


CYATHUSAL C

An organic heterotricyclic compound that is 1H,6H-pyrano[4,3-c]isochromene-7-carbaldehyde substituted by hydroxy groups at positions 9 and 10, methoxy group at position 8, oxo group at position 1, a propan-2-yloxy group at position 6 and a propenyl group at position 3. It is isolated from the fermented mushroom Cyathus stercoreus and exhibits radical scavenging activities.


An imidazoindole that is 9H-imidazo[1,2-a]indole which is substituted at positions 2, 3, and 9 by cyano, amino, and oxo groups, respectively.


cassiaside C2

An organic heterotricyclic compound that is 9,10-dihydroxy-7-methoxy-3-methyl-1H-benzo[g]isochromen-1-one attached to a tetrasaccharide residue at position 9 via a glycosidic linkage. Isolated from Cassia obtusifolia, it exhibits anti-allergic activity.


beraprost

An organic heterotricyclic compound that is (3aS,8bS)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan in which the hydrogens at positions 1R, 2R and 5 are replaced by (3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl, hydroxy and 3-carboxypropyl groups, respectively. It is a prostaglandin receptor agonist which is approved to treat pulmonary arterial hypertension in Asia.


A benzopteridine that is riboflavin in which the methyl group at position 8 has been replaced by an amino group.


triazolobenzodiazepine

Any organic heterotricyclic compound that is any benzodiazepine which is ortho-fused with a triazole.


CHAETOVIRIDIN H

An  azaphilone that is 6H-furo[2,3-h]isochromene-6,8(6aH)-dione substituted by a 3-hydroxy-2-methylbutanoyl group at position 9, a methyl group at position 6a and a 3-methylpent-1-en-1yl group at position 3. It has been isolated from Chaetomium globosum.


dibenzothiophene sulfone

A sulfone resulting from the oxidation of the sulfur atom of dibenzothiophene.


A member of the class of dibenzofurans that is dibenzo[b,d]furan substituted by a hydroxy group at position 3 and chloro groups at positions 6 and 7 respectively.


harmaline

A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7 and has been reduced across the 3,4 bond.


triazaacenaphthylene

Any organonitrogen heterocyclic compound which contains an acenaphthylene skeleton in which three of the carbons are replaced by nitrogens.


BRUCEOLLINE E

An indole alkaloid that is 1,2,3,4-tetrahydrocyclopenta[b]indole substituted by geminal-methyl groups at position 3 and oxo groups at positions 1 and 2. It has been isolated from the ethanol extract of the stems of Brucea mollis.


(+)-corvol ether B

A tricyclic sesquiterpenoid with formula C15H26O which is biosynthesised from farnesyl diphosphate by a sesquiterpene cyclase enzyme from Kitasatospora setae.


The reduced 1,5-dihydro form of flavin mononucleotide.


An organic heterotricyclic compound that is 1H,10H-pyrano[4,3-b]chromene substituted by hydroxy groups at positions 7 and 8, a methoxy group at position 1, a methyl group at position 3 and an oxo group at position 10. Isolated from Chaetomium funicola, it exhibits inhibitory activity against metallo-beta-lactamases.


beta-aminoorceimine

A member of the class of phenoxazines that is 3-imino-1,9-dimethyl-3H-phenoxazine carrying an additional amino substituent at position 7 as well as two 2,4-dihydroxy-6-methylphenyl substituents at positions 2 and 8. The isomer in which the hydroxy groups at positions 2' and 2'' on the phenyl rings are both on the same side of the plane of the phenoxazine ring system. A component of orcein, a mixture of dyes isolated from lichens.


alpha-aminoorcein

A member of the class of phenoxazines that is 1,9-dimethyl-3H-phenoxazin-3-one carrying additional amino and 2,4-dihydroxy-6-methylphenyl substituents at positions 7 and 8 respectively. A component of orcein, a mixture of dyes isolated from lichens.


naphthopyran

Any organic heterotricyclic compound with a skeleton consisting of a pyran ring ortho-fused to a naphthalene.


PHENANTHRIDINE

An azaarene that is the 9-aza derivative of phenanthrene. The parent of the class of phenanthridines.


name: 3-(methylsulfamoyl)benzoic acid [2-[(9-ethyl-3-carbazolyl)amino]-2-oxoethyl] ester


name: N-methylcarbamic acid [(8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] ester


imidazoquinoxaline

Any organic heterotricyclic compound with a skeleton consisting of an imidazole ring ortho-fused to a quinoxaline.


ORBICULIN A

A dihydroagarofuran sesquiterpenoid that consists of dihydro-beta-agarofuran substituted by an acetoxy groups at positions 1 and 2 and benzoyloxy groups at positions 6 and 9 (the 1beta,2beta,6alpha,9alpha stereoisomer). Isolated from Celastrus orbiculatus, it exhibits inhibition of both NF-kappaB activation and nitric oxide production.


bergapten

A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5.


ICR 340 (free base)

An organic heterotricyclic compound that is benzo[b][1,5]naphthyridine substituted by methoxy, chloro and {3-[(2-chloroethyl)(ethyl)amino]propyl}amino groups at positions 2, 7 and 10, respectively.


A dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective gamma-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss.


imidazochromene

An organic heterotricyclic compound that consists of a chromene ring system having an imidazole ring ortho-fused at any position.


BAUHINOXEPIN I

A dibenzooxepine that is 10,11-dihydrodibenzo[b,f]oxepine-1,4-dione substituted by a hydroxy, a methoxy and a methyl group at positions 8, 2 and 3 respectively. It is isolated from the root extract of Bauhinia purpurea and exhibits antimalarial, antimycobacterial, antifungal, anti-inflammatory and cytotoxic activities.


(S)-DNPA

A member of the class of naphthopyrans that is 4,10-dihydro-3H-naphtho[2,3-c]pyran-3-yl]acetic acid bearing additional methyl, hydroxy and oxo substituents at positions 1, 9 and 10 respectively.


AF-DX 384

A pyridobenzodiazepine that acts as a selective antagonist of the muscarinic acetylcholine receptors.


ascomycotin A

An organic heterotricyclic compound that is 3,4-dihydro-2H,5H-pyrano[3,2-c]chromene substituted by methyl, oxo, hydroxy, methoxy and methoxycarbonyl groups at positions 2R, 4, 7, 8 and 10, respectively. It is isolated from the fungal strain Ascomycota sp. Ind19F07, which was isolated from the deep sea sediment of the Indian Ocean.


A furanocoumarin that is 2,3-dihydrofuro[3,2-c]coumarin substituted by a methoxy group at position 7, methyl groups at positions 2 and 3 (relatively cis configuration) and a 4-methyl-5-(4-methyl-2-furyl)-3(E)-pentenyl moiety at position 2. Isolated from the roots of Ferula fukanensis and Ferula ferulioides, it exhibits inhibitory activity against production of nitric oxide (NO).


A dipyridodiazepine that is nevirapine in which one of the hydrogens of the methyl group has been substituted by a hydroxy group. It is a metabolite of the anti-HIV drug, nevirapine.


CHERMESINONE B

An  azaphilone that is 9,9a-dihydro-6H-furo[2,3-h]isochromene-6,8(6aH)-dione substituted by methyl groups at positions 3 and 6a and a 2-methylbutanoyl group at position 9. It has been isolated from the culture of the mangrove endophytic fungus Penicillium chermesinum.


methdilazine

A phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group; a first-generation antihistamine with anticholinergic properties.


LISSOCLIBADIN 3

A member of the class of  thianthrenes that is thianthrene substituted by methoxy groups at positions 3, 4, 8 and 9, methylsulfanyl groups at positions 2 and 7 and 2-(dimethylamino)ethyl groups at positions 1 and 6. Isolated from the ascidian Lissoclinum badium, it exhibits cytotoxicity against human cancer cells.


triazolophthalazine

An organic heterotricyclic compound comprising a triazole ring fused to a phthalazine ring system.


SIAMENOL

A carbazole alkaloid that is 9H-carbazole substituted by a hydroxy group at position 2, a methyl group at position 6 and a prenyl group at position 3. Isolated from Murraya siamensis, it exhibits anti-HIV activity.


roseoflavin

A benzopteridine that is riboflavin in which the methyl group at position 8 is substituted by a dimethylamino group.


aurachin C epoxide

An epoxide resulting from the oxidation of the double bond at the 2-3 position of aurachin C.


thymidine 5'-monophosphate dimer

A cyclobutadipyrimidine bis(deoxyribonucleotide) obtained by formal cyclodimerisation of thymidine 5'-monophosphate.


name: 1,2,3,4-tetrahydroacridine-9-carboxylic acid [2-(3-chloro-4-methoxyanilino)-2-oxoethyl] ester


A member of the class of diazepinoindoles that is 1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indole substituted by piperidin-1-ylcarbonyl, 4-(imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl and fluoro groups at position 2, 7 and 9, respectively. It is a potent ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 values of 1.5 nM and 0.9 nM for GSK-3alpha and GSK-3beta. The drug is in clinical development for the treatment of advanced/metastatic cancer.


perazine

A phenothiazine derivative in which 10H-phenothiazinecarries a 3-(4-methylpiperazin-1-yl)propyl substituent at the N-10 position.


texazone

A member of the class phenoxazines that is 3H-phenoxazine substituted by methylamino, oxo and carboxy groups at positions 2, 3, and 8, respectively. It is a natural product produced by the soil bacterium Saccharopolyspora taberi.


tanariflavanone A

A  hydroxyflavanone with a  pyranochromane skeleton that is 3,4,7,8-tetrahydro-2H,6H-pyrano[3,2-g]chromen-6-one substituted by geminal methyl groups at position 2, hydroxy groups at positions 3 and 5 and a phenyl group at position 8 which in turn is substituted by a geranyl group at position 2 and hydroxy groups at positions 3 and 4. Isolated from Macaranga tanarius, it exhibits alleopathic effect.


A naphthofuran that is naphtho[2,3-b]furan-4,9-dione substituted by a hydroxy group at position 8 and a 1-hydroxyethyl group at position 2. Isolated from Tabebuia impetiginosa and Kigelia pinnata, it exhibits antineoplastic activity.


An extended flavonoid that consists of (2S)-flavanone substituted by hydroxy groups at positions 5 and 3', a methoxy group at position 4' , a prenyl group at position 6 and a gem-dimethylpyran ring fused across positions 7 and 8. Isolated from Lonchocarpus utilis and Lonchocarpus urucu, it acts as a NADH:ubiquinone reductase inhibitor.


OCHROCARPINONE B

A beta-diketone isolated from Ochrocarpos punctatus and has been shown to exhibit antineoplastic activity.


bathocuproine disulfonic acid

A phenanthroline that consists of 1,10-phenanthroline bearing two methyl groups at position 2 and 9 as well as two 4-sulfophenyl groups at positions 4 and 7.


WISKOSTATIN

A 1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol that is the (S)-enantiomer of wiskostatin.


carphenazine

A member of the class of phenothiazines that is 10H-phenothiazine which carries a propanoyl group at position 2 and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at position N-10. It is an antipsychotic drug that is used for the treatment of chronic schizophrenia.


MoO2-molybdopterin cofactor

An Mo-molybdopterin cofactor in which the coordinated molybdenum species is MoO2.


elongatol E

A sesquiterpenoid that is 1,2,3a,4,5,5a,8,9,9a,9b-decahydronaphtho[2,1-b]furan substituted by methyl groups at positions 1, 9 and 9a and hydroxy groups at positions 2 and 5a. Isolated from methylene chloride solubles of the Formosan soft coral Nephthea elongata, it exhibits cytotoxicity against selected cancer cells.


ASCIDIATHIAZONE B

An organic heterotricyclic compound, that is 5,10-dioxo-5,10-dihydro-1H-[1,4]thiazino[3,2-g]quinoline 4,4-dioxide substituted at position 7 by a carboxy group. It is an anti-inflmmatory alkaloid obtained from Aplidium.


NAXAGOLIDE

An organic heterotricyclic compound that is (4aR,10bR)-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazine substituted by propyl and hydroxy groups at positions 4 and 9, respectively. It is a potent dopamine D2-receptor agonist and its hydrochloride salt was under clinical development by Merck & Co as a potential antiparkinsonian agent (now discontinued).


A naphthofuran that is naphtho[2,3-b]furan-4,9-dione substituted by a hydroxy group at position 5 and a 1-hydroxyethyl group at position 2 (the S stereoisomer). Isolated from Tabebuia impetiginosa and Tabebuia avellanedae, it exhibits antineoplastic activity.


A member of the class of phenazines that is 5,10-dihydrophenazine substituted at positions 1 and 9 by carboxy and dimethylallyl groups respectively.


name: acetic acid 2-(7-oxo-2,3-dihydrofuro[3,2-g][1]benzopyran-2-yl)propan-2-yl ester


HARMAN

An indole alkaloid fundamental parent with a structure of 9H-beta-carboline carrying a methyl substituent at C-1. It has been isolated from the bark of Sickingia rubra, Symplocus racemosa, Passiflora incarnata, Peganum harmala, Banisteriopsis caapi and Tribulus terrestris, as well as from tobacco smoke. It is a specific, reversible inhibitor of monoamine oxidase A.


GRIXAZONE B

A cysteine derivative that is the S-(2-amino-8-carboxy-3-oxo-3H-phenoxazin-1-yl) derivative of N-acetyl-L-cysteine.


proflavine

An aminoacridine that is acridine that is substituted by amino groups at positions 3 and 6. A slow-acting bacteriostat that is effective against many Gram-positive bacteria (but ineffective against spores), its salts were formerly used for treatment of burns and infected wounds.


PEUCEDANIN

A member of the class of furanocoumarins that is furo[3,2-g]chromen-7-one, bearing additional isopropyl and methoxy substituents at positions 2 and 3 respectively.


poly(vinylcarbazole) macromolecule

A macromolecule composed of repeating 9-ethylcarbazole units.


A W-molybdopterin cofactor comprising two molecules of molybdopterin guanine dinucleotide attached via their sulfur atoms to a central tungsten atom.


An imidazoquinoline that is 1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one which is substituted at positions 1, 3, and 8 by by p-(pyrrol-1-yl)phenyl, methyl, and pyridin-3-yl group, respectively. A potent and specific inhibitor of Target Of Rapamycin Complex 2 (TORC2).


thionine cation

The cationic form of 3,7-diaminophenothiazine.


metiazinic acid

Phenothiazine substituted at nitrogen by a methyl group and at C-2 by a carboxymethyl group.


name: 4-[[9-methyl-2-(2-methylpropyl)-1-oxo-4-pyrido[3,4-b]indolyl]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester


pacein

A member of the class of benzofurans that is dibenzo[b,d]furan-3,7-dione bearing two methyl substituents at positions 1 and 9 as well as two 2,4-dihydroxy-6-methylanilino substituents at positions 2 and 8.


14-deacetyl astellolide B

Major species at pH 7.3.


Product of reaction described in DOI:10.1016/S0040-4039(00)96715-7


decarbamoylsaxitoxin

A pyrrolopurine that is 2,6-diiminodecahydropyrrolo[1,2-c]purine carrying an additional hydroxymethyl substituent at position 4 as well as two hydroxy substituents at position 10. A toxin that is isolated from marine dinoflagellates and cyanobacteria and is known to cause paralytic shellfish poisoning.


15-acetoxyorbiculin G

A dihydroagarofuran  sesquiterpenoid that is the 15-acetoxy derivative of orbiculin G. It is isolated from Microtropis japonica and exhibits antitubercular activity.


pyrimido-indole

Any organic heterotricyclic compound with a skeleton consisting of a pyrimidine ring fused to an indole.


A dibenzopyran that is Delta(9)-tetrahydrocannabinol which is lacking the hydroxy group and in which the pentyl group at position 3 has been replaced by a 1,1-dimethylbutyl group. A potent and highly selective CB2 receptor agonist.


(3aR,4S,9bS)-golgicide A

A 6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline that has 3aR,4S,9bS configuration.


ROCAGLAMIDE

An organic heterotricyclic compound that is 2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan substituted by hydroxy groups at positions 1 and 8b, methoxy groups at positions 6 and 8, a 4-methoxyphenyl group at position 3a, a phenyl group at position 3 and a N,N-dimethylcarbamoyl group at position 1. Isolated from Aglaia odorata and Aglaia duperreana, it exhibits antineoplastic activity.


thiopropazate

A phenothiazine derivative in which 10H-phenothiazine has a chloro subsitituent at the 2-position and a 3-[4-(2-acetoxyethyl)piperazin-1-yl]propyl group at N-10.


laccaridione A

An organic heterotricyclic compound that is 1H-benzo[g]isochromene-8,9-dione substituted by a hydroxy group at position 10, methoxy groups at positions 1 and 7 and a 4-methylhex-2-en-2-yl group at position 3. Isolated from the stem of the fruiting bodies of the basidiomycete strain Laccaria amethystea, it exhibits inhibitory activity against proteases.


A pyranobenzodioxin obtained by formal cyclocodensation between syringylglycerol and esculetin. It is found in Arabidopsis thaliana.


iso-precytochalasin

A cytochalasan alkaloid found in Aspergillus clavatus.


LUMIFLAVIN

A compound showing yellow-green fluorescence, formed by a photolysis of riboflavin in alkaline solution.


papulacandin B

A papulacandin that is papulacandin A in which the (2E,4E)-deca-2,4-dienoyl chain at the O-(6') position is replaced by a (2E,4Z,6E)-8-hydroxydeca-2,4,6-trienoyl chain. It is the major carbohydrate-containing antibiotic from the deuteromycetous fungus Papularia sphaerosperma which shows potent antifungal activity against Candida albicans.


anthramycin

A member of the class of pyrrolobenzodiazepines that is (11aS)-5,10,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine substituted at positions 2, 5, 8, 9 and 11R by a (1E)-3-amino-3-oxoprop-1-en-1-yl, oxo, methyl, hydroxy and hydroxy groups, respectively. It is a natural product isolated from Streptomyces refuineus subsp. thermotolerans.


CEPHAELINE

A pyridoisoquinoline comprising emetam having a hydroxy group at the 6'-position and methoxy substituents at the 7'-, 10- and 11-positions.


oxadiazoloquinoxaline

An organic heterotricyclic compound that consists of an oxadiazole ring ortho-fused at any position to a quinoxaline ring system.


(+)-SKF 10.047

The (+)-stereoisomer of SKF-10,047.


xyloketal D

A xyloketal with formula C15H18O4. It was initially isolated from the mangrove fungus Xylaria sp. from the South China sea coast.


dactolisib

An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.


An extended flavonoid that consists of (2S)-flavanone substituted methoxy groups at positions 3' and 4', a prenyl group at position 6 and a gem-dimethylpyran ring fused across positions 7 and 8. Isolated from Lonchocarpus utilis and Lonchocarpus urucu, it acts as a NADH:ubiquinone reductase inhibitor.


MANZAMINE Y

An alkaloid that is manzamine A with a hydroxy substituent at position 6. Isolated from Haliclona and Acanthostrongylophora, it exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).


pentalenolactone E

A sesquiterpene lactone obtained by formal dehydrogenation of the 4-methyl position of pentalenolactone D.


chaetocyclinone B

An organic heterotricyclic compound that is 1H,10H-pyrano[4,3-b]chromene substituted by methyl, hydroxy, methoxy, methoxycarbonyl, and oxo groups at positions 3, 6, 7, 9 and 10, respectively. It is produced by cultures of Chaetomium sp. Goe 100/2, which was isolated from marine algae.


DICHOTOMIDE III

A  beta-carboline alkaloid isolated from Stellaria dichotoma var. lanceolata. S


pyrrolobenzodiazepine

Any organic heterotricyclic compound with a skeleton consisting of a pyrrole ring ortho-fused at any position to a benzodiazepine bicyclic system.


acetophenazine

A member of the class of  phenothiazines that is 10H-phenothiazine substituted by a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the nitogen atom and an acetyl group at position 2.


Flavin-adenine dinucleotide (FAD) in which the hydrogen at position 6 of the benzo[g]pteridinedione moiety is substituted by a hydroxy group.


tomaymycin

A pyrrolobenzodiazepine that is (11aS)-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine which is substituted at positions 2,5,7,8 and 11R by ethylidene, oxo, methoxy, hydroxy and methoxy groups, respectively. It is a natural product of Streptomyces achromogenes that binds covalently with guanine in the minor groove of DNA. It is an antitumoral compound which is active in ovarian, plasmacytoma, and leukemia cancer cell lines at nanomolar concentrations.


flumazenil

An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.


name: 5-hydroxy-2-methyl-3-benzo[g]benzofurancarboxylic acid ethyl ester


ALPHA-NAPHTHOFLAVONE

An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).


quinpirole

A pyrazoloquinoline that is  (4aR,8aR)-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline substituted by a propyl group at position 5. It acts as a dopamine agonist.


chanoclavine-I

An organic tricyclic compound that is 1,3,4,5-tetrahydrobenzo[cd]indole which is substituted at position 4 by a methylamino group and at position 5 by a 3-hydroxy-2-methylprop-1-en-1-yl group (the 4R,5R,E diastereoisomer). It is a precursor of the tetracyclic ergolines agroclavine, elymoclavine and lysergic acid amide.


An organic cation consisting of beta-carboline having methyl and hydroxy substituents at the 2- and 6-positions respectively.


An organic heterotricyclic compound comprising a decahydropyrano[2',3':5,6]pyrano[3,2-b]oxepin ring system having hydroxy, methoxymethyl and carboxymethyl substituents.


thioxanthenes

Thioxanthene and its substitution derivatives.


A guaiane sesquiterpenoid isolated from Elephantopus mollis and has been shown to exhibit cytotoxic activity.


adinazolam

A triazolo[4,3-a][1,4]benzodiazepine having a dimethylaminomethyl group at the 1-position, a phenyl group at the 6-position and a chloro substituent at the 8-position.


nodakenetin

A marmesin with R-configuration.


dolutegravir

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1.


SIBIROMYCIN

An aminoglycoside antibiotic produced by Streptosporangium sibiricum that also exhibits antitumour properties.


djalonensone

A benzochromenone that is alternariol in which the hydroxy group at position 9 has been converted into the corresponding methyl ether. A natural product found in Chaetomium globosum as well as being one of the two most important compounds belonging to the group of Altenaria mycotoxins.


neutral red base

A member of the class of phenazines carrying methyl, amino and dimethylamino substituents at positions 2, 3 and 7 respectively. The free base of neutral red, which acts as a pH indicator, changing from red to yellow between pH 6.8 and 8.0.


dihydroemetine

A pyridoisoquinoline which was developed in response to the cardiovascular toxicity associated with emetine and results from the dehydrogenation of the heterotricylic ring of emetine. It is an antiprotozoal agent and displays antimalarial, antiamoebic, and antileishmanial properties.


epicocconone

A natural cell-permeable fluorescent compound isolated from the fungus Epicoccum nigrum.


8-deoxylactucin 15-oxalate

A sesquiterpene lactone obtained by formal condensation of one of the carboxy groups of oxalic acid with the 15-hydroxy group of 8-deoxylactucin. Found in chicory.


scytonemin

A ring assembly obtained by 1,1'-coupling of two molecules of (3E)-3-[(4-hydroxyphenyl)methylidene]cyclopenta[b]indol-2(3H)-one. A UV-screening molecule produced by many strains of cyanobacteria.


nevirapine

A dipyridodiazepine that is  5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.


galaxolidone

An  organic heterotricyclic compound that is 4,6,7,8-tetrahydrocyclopenta[g]isochromen-1(3H)-one substituted by methyl groups at positions 4, 6, 6, 7, 8 and 8 respectively. It is a metabolite of the synthetic musk galaxolide.


ARUGOSIN A

A dibenzooxepine that is dibenzo[b,e]oxepin-11(6H)-one which is substituted by hydroxy groups at positions 1, 6, and 10, a 3,3-dimethylallyl group at position 2, a 3,3-dimethylallyloxy group at position 7, and a methyl group at position 8.


acetylseneciphylline

A pyrrolizine alkaloid that is seneciphylline in which the hydroxy hydrogen has been replaced by an acetyl group.


A sesquiterpene lactone obtained by formal condensation of one of the carboxy groups of oxalic acid with the 15-hydroxy group of 11beta,13-dihydrolactucopicrin. Found in chicory.


A  sesquiterpene lactone that is the C-8 epimer of helenalin. Isolated from the aerial parts of Inula hupehensis, it exhibits  anti-inflammatory activity.


A pseudoguaianolide with anti-inflammatory activity isolated from the aerial parts of Inula hupehensis.


oxazinoquinoline

Any organic heterotricyclic compound based on a skeleton comprised of an oxazine ring fused onto a quinoline system.


CARBAMAZEPINE EPOXIDE

An  epoxide and metabolite of carbamazepine.


An L-alanine derivative that is L-alanine in which one of the methyl hydrogens is substituted by an acridonyl group. It is a flourescent probe used for monitoring conformational changes in proteins.


A beta-carboline that is 2,3,4,4a,9,9a-hexahydro-1H-beta-carboline in which the hydrogens at positions 1, 2 and 3 are replaced by 4-(methoxycarbonyl)phenyl, chloroacetyl and methoxycarbonyl groups, respectively (the 1S,2R stereoisomer). It is a potential antineoplastic agent which triggers ferroptosis by inactivating the glutathione peroxidase 4 (GPX4) enzyme.


MOLLICELLIN L

A member of the class of depsidones that is 11H-dibenzo[b,e][1,4]dioxepine substituted by a hydroxy group at position 3, a methoxy group at position 7, methyl groups at positions 1 and 9, a 3-methylbut-2-enoyl group at position 8, a formyl group at position 4 and an oxo group at position 11. Isolated from Chaetomium brasiliense, it exhibits antimalarial and cytotoxic activities.


A sesquiterpenoid that is 4,4a,7,8,8a,9-hexahydronaphtho[2,3-b]furan  substituted by methyl groups at positions 3, 5 and 8a and an oxo group at position 9 (the 4aS,8aS stereoisomer). It is isolated from the methanol extract of the whole plant of Chloranthus japonicus and acts as a chitin synthase inhibitor. CJ-01 also shows antifungal activity against various human and phytophathogenic fungi.


PROTUBOXEPIN A

An organic heterotricyclic compound that is  10,11-dihydro-6H-oxepino[2,3-d]pyrazino[1,2-a]pyrimidine-6,9(8H)-dione substituted by a benzyl group at position 8 and a butan-2-yl group at position 11. It has been isolated from Aspergillus species.


pyrrolopurine

Any organic heterotricyclic compound with a skeleton consisting of a pyrrole ring fused to a purine ring system.


betagarin

An extended flavonoid that is 6,7-methylenedioxyflavanone substituted by methoxy groups at positions 5 and 2' respectively.


(S)-selisistat

A 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide that has S configuration It is the active enantiomer.


lactucin 15-glycoside

A terpene glycoside obtained by glycosylation of the 15-hydroxy group of lactucin. Found in chicory.


lonafarnib

A 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide that has R configuration. It is used as oral farnesyltransferase inhibitor.


hemiustilaginoidin D

A naphtho-gamma-pyrone which carries hydroxy substituents at positions C-5, C-6 and C-8 and methyl groups at C-2 and C-3. Obtained from the laccase gene deletion mutant of Villosiclava virens (anamorph: Ustilaginoidea Virens), it is a precursor of ustilaginoidins used as the raw material for hapten synthesis through diazotization and Mannich reactions followed by bioconjugation with carrier proteins for complete antigen synthesis.


CYATHUSAL A

An organic heterotricyclic compound that is 1H,6H-pyrano[4,3-c]isochromene-7-carbaldehyde substituted by hydroxy groups at positions 9 and 10, methoxy group at position 8, oxo group at position 1 and a propenyl group at position 3. It is isolated from the fermented mushroom Cyathus stercoreus and exhibits radical scavenging activities.


A member of the class of phenazines that is phenazine substituted by hydroxy groups at positions 1 and 6.


pyrroloquinoline quinol

A pyrroloquinoline having hydroxy groups at the 4- and 5-positions and carboxy groups at the 2-, 7- and 9-positions.


alpha-hydroxyorcein

A member of the class of phenoxazines that is 1,9-dimethyl-3H-phenoxazin-3-one carrying additional hydroxy and 2,4-dihydroxy-6-methylphenyl substituents at positions 7 and 8 respectively. A component of orcein, a mixture of dyes isolated from lichens.


BENTHOPHOENIN

A member of the class of phenazines that is 5,10-dihydrophenazine-1-carboxylic acid substituted by benzoyl groups at positions 3 and 7 and a geranyl moiety at position 5. It is isolated from the mycelium of Streptomyces prunicolor and acts as a free radical scavenger.


An azaphilone that is 7,8-dihydro-6H-oxireno[j]isochromene substituted by a hepta-1,3,5-trien-1-yl group at position 3, a [3-hydroxybutanoyl]oxy group at position 7, a methyl group at position 7 and oxo groups at positions 6 and 8 respectively (the 3S,7S stereoisomer). A fungal metabolite, it is isolated from the fermentation broth of Penicillium solitum strain CT2108 and exhibits inhibitory activity against fatty acid synthase as well as fungicidal activity.


Me-YTM-T

A member of the class of pyrroloindoles that is an intermediate in the biosynthesis of yatakemycin by Streptomyces sp. TP-A0356.


hemiustilaginoidin F

A naphtho-gamma-pyrone which carries hydroxy substituents at positions C-5, C-6 and C-8 and a methyl group at C-2. Obtained from the laccase gene deletion mutant of Villosiclava virens (anamorph: Ustilaginoidea Virens), it is a precursor of ustilaginoidins used as the raw material for hapten synthesis through diazotization and Mannich reactions followed by bioconjugation with carrier proteins for complete antigen synthesis.


cleistanthins

Any of the lignans with a 9-aryl-1-oxo-1,3-dihydronaphtho[2,3-c]furan-4-yl glycoside skeleton originally isolated from Cleistanthus collinus, a toxic deciduous shrub. While all parts of the plant are poisonous, the leaves in particular are used as a suicide poison by young women in rural parts of southern India. Cleistanthins A and B have been particularly associated with the toxicity of the plant, with cleistanthin A being more potent than cleistanthin B.


A pseudoguaianolide isolated from the aerial parts of Inula hupehensis.


An organic heterotricyclic compound that is 4,5-dihydro-1H-[1,3]thiazolo[4,5-g]indazole which is substituted at positions 1, 3 and 7 by 2-chlorophenyl, pyridin-3-yl, and [(1H-imidazol-2-ylmethyl)carbamoyl]amino groups, respectively.


LICARBAZEPINE

A dibenzoazepine that is 5H-dibenzo[b,f]azepine, reduced across the C-10,11 positions and carrying a carbamoyl substituent at the azepine nitrogen and a hydroxy function at C-10. A voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects, it is related to oxcarbazepine and is an active metabolite of oxcarbazepine.


LAPACHONE

A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.


(S)-flumequine

A 9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid that is the (S)-enantiomer of flumequine.


Functioning Lung Carcinoid Tumor

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A lung neuroendocrine tumor that is associated with carcinoid syndrome.


name: voltage-dependent anion-selective channel protein 3 isoform 1 (mouse)

description: A voltage-dependent anion-selective channel protein 3 isoform 1 that is encoded in the genome of mouse.


name: VDAC3_MOUSE Voltage-dependent anion-selective channel protein 3 (sprot)

description: A voltage-dependent anion-selective channel protein 3 that is encoded in the genome of mouse.


name: F-box only protein 46 methylated 1 (human)

description: An F-box only protein 46 (human) that has been methylated on the residue at the position equivalent to Cys-306 of the amino acid sequence represented by UniProtKB:Q6PJ61. UniProtKB:Q6PJ61, Cys-306, MOD:00660.


name: receptor-type tyrosine-protein phosphatase C isoform CD45RA, signal peptide removed form

description: A receptor-type tyrosine-protein phosphatase C isoform CD45RA that has had the signal peptide removed.


name: receptor-type tyrosine-protein phosphatase C isoform CD45RA

description: A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-8 or a 1:1 ortholog thereof.


name: receptor-type tyrosine-protein phosphatase C isoform CD45RA, signal peptide removed glycosylated form

description: A receptor-type tyrosine-protein phosphatase C isoform CD45RA, signal peptide removed form that includes at least one glycosylated residue.


name: receptor-type tyrosine-protein phosphatase C isoform CD45RA (human)

description: A receptor-type tyrosine-protein phosphatase C isoform CD45RA that is encoded in the genome of human.


name: vascular endothelial growth factor A, long form isoform mL-VEGF-2 (mouse)

description: A vascular endothelial growth factor A, long form (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00731-7.


name: TM2D1_DROME TM2 domain-containing protein CG10795 (sprot)

description: A TM2 domain-containing protein 1 that is encoded in the genome of fruit fly.


name: ATP-dependent DNA/RNA helicase DHX36 deaminated 2 (human)

description: An ATP-dependent DNA/RNA helicase DHX36 (human) that has been deaminated on the residue at the position equivalent to Asn-247 of the amino acid sequence represented by UniProtKB:Q9H2U1-1. Example: UniProtKB:Q9H2U1-1, Asn-247, MOD:00684.


name: cleavage stimulation factor subunit 3 isoform 1 (mouse)

description: A cleavage stimulation factor subunit 3 isoform 1 that is encoded in the genome of mouse.


The conjugate acid of oleandomycin arising from protonation of the tertiary amino group; major species at pH 7.3.


ceramide synthase 6 isoform 1 (human)

A ceramide synthase 6 isoform 1 that is encoded in the genome of human.


name: negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros.


name: a disintegrin and metalloproteinase with thrombospondin motifs 6 isoform h3 (human)

description: An a disintegrin and metalloproteinase with thrombospondin motifs 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UKP5-3.


name: E3 ubiquitin-protein ligase Arkadia isoform m2 (mouse)

description: An E3 ubiquitin-protein ligase Arkadia (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99ML9-2.


name: E3 ubiquitin-protein ligase Arkadia isoform m1 (mouse)

description: An E3 ubiquitin-protein ligase Arkadia (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99ML9-1.


fibronectin O-glycosylated 10 (human)

A fibronectin (human) that has been O-glycosylated at the residue equivalent to Thr-278 of the amino acid sequence represented by UniProtKB:P02751-15, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P02751-15, Thr-278, MOD:00005~GNO:G58001LT.


name: hepatoencephalopathy due to combined oxidative phosphorylation defect type 1

description: Hepatoencephalopathy due to combined oxidative phosphorylation deficiency type 1 is a rare, inherited mitochondrial disorder due to a defect in mitochondrial protein synthesis characterized by intrauterine growth retardation, metabolic decompensation with recurrent vomiting, persistent severe lactic acidosis, encephalopathy, seizures, failure to thrive, severe global developmental delay, poor eye contact, severe muscular hypotonia or axial hypotonia with limb hypertonia, hepatomegaly and/or liver dysfunction and/or liver failure, leading to fatal outcome in severe cases. Neuroimaging abnormalities may include corpus callosum thinning, leukodystrophy, delayed myelination and basal ganglia involvement.


synaptotagmin-7 isoform r7 (rat)

A synaptotagmin-7 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q62747-7.


name: MMP25_MOUSE Matrix metalloproteinase-25 (sprot)

description: A matrix metalloproteinase-25 that is encoded in the genome of mouse.


name: pyridoxine/pyridoxamine 5'-phosphate oxidase, initiator methionine removed form

description: A pyridoxine/pyridoxamine 5'-phosphate oxidase that has had the initiator methionine removed.


name: ankyrin repeat domain-containing protein 29 isoform h3 (human)

description: An ankyrin repeat domain-containing protein 29 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N6D5-3.


name: transient receptor potential cation channel subfamily M member 2 isoform h2 (human)

description: A transient receptor potential cation channel subfamily M member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O94759-2.


GALM_ECOLI Aldose 1-epimerase (sprot)

A galactose mutarotase that is encoded in the genome of Escherichia coli K-12.


A deosygulose that is beta-D-gulopyranose in which the hydroxy group at position 6 has been replaced by a hydrogen.


name: fatty acid desaturase 4-like 2, chloroplastic isoform 1 (Arabidopsis thaliana)

description: A fatty acid desaturase 4-like 2, chloroplastic (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O81006-1.


name: TF2H1_DICDI General transcription factor IIH subunit 1 (sprot)

description: A general transcription factor IIH subunit 1 that is encoded in the genome of Dictyostelium discoideum.


name: NCSEB_DICDI Neutral ceramidase B (sprot)

description: A protein that is a translation product of the dcd2B gene in Dictyostelium discoideum.


VERTINE

A quinolizidine alkaloid isolated from the flowering plant Heimia salicifolia and exhibits anti-inflammatory properties.


name: mediator of RNA polymerase II transcription subunit 20 isoform 3 (mouse)

description: A mediator of RNA polymerase II transcription subunit 20 isoform 3 that is encoded in the genome of mouse.


name: Y2188_DICDI von Willebrand factor A domain-containing protein DDB_G0292188 (sprot)

description: A protein that is a translation product of the DDB_G0292188 gene in Dictyostelium discoideum.


name: kinesin-like protein Klp98A isoform B (fruit fly)

description: A kinesin-like protein Klp98A (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9VB25-2.


name: KL98A_DROME Kinesin-like protein Klp98A (sprot)

description: A protein that is a translation product of the Klp98A gene in fruit fly.


name: DIM1_DROME Probable dimethyladenosine transferase (sprot)

description: A probable dimethyladenosine transferase that is encoded in the genome of fruit fly.


name: phosphatidylserine lipase ABHD16A isoform 1 (human)

description: A phosphatidylserine lipase ABHD16A isoform 1 that is encoded in the genome of human.


name: glycerol-3-phosphate dehydrogenase [NAD(+)] At3g07690, cytosolic isoform 2 (Arabidopsis thaliana)

description: A glycerol-3-phosphate dehydrogenase [NAD(+)] At3g07690, cytosolic (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9S785-2.


name: cyclin-Y-like protein 1 isoform h3 (human)

description: A cyclin-Y-like protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N7R7-3.


name: CITX_ECOLI Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (sprot)

description: An apo-citrate lyase phosphoribosyl-dephospho-CoA transferase that is encoded in the genome of Escherichia coli K-12.


name: apo-citrate lyase phosphoribosyl-dephospho-CoA transferase

description: A protein that is a translation product of the Escherichia coli K-12 citX gene or a 1:1 ortholog thereof.


rhizobactin 1021 biosynthetic process

description: The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti.


tertiary alcohol metabolic process

description: The chemical reactions and pathways involving tertiary alcohol.


rhizobactin 1021 metabolic process

description: The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti.


cis-abienol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cis-abienol.


tetracenomycin C catabolic process

description: The chemical reactions and pathways resulting in the breakdown of tetracenomycin C.


cortisol metabolic process

description: The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.


tetracenomycin C metabolic process

description: The chemical reactions and pathways involving tetracenomycin C.


neosartoricin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of neosartoricin.


paxilline biosynthetic process

description: The chemical reactions and pathways resulting in the formation of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels.


rhodopsin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas.


asperfuranone catabolic process

description: The chemical reactions and pathways resulting in the breakdown of asperfuranone.


cortisol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.


viridicatumtoxin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system.


neosartoricin metabolic process

description: The chemical reactions and pathways involving neosartoricin.


asperfuranone biosynthetic process

description: The chemical reactions and pathways resulting in the formation of asperfuranone.


tetracenomycin C biosynthetic process

description: The chemical reactions and pathways resulting in the formation of tetracenomycin C.


tertiary alcohol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of tertiary alcohol.


cis-abienol metabolic process

description: The chemical reactions and pathways involving cis-abienol.


cis-abienol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of cis-abienol.


neosartoricin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of neosartoricin.


paraherquonin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture.


asperfuranone metabolic process

description: The chemical reactions and pathways involving asperfuranone.


KUP1_CAEEL Protein kup-1 (sprot)

A protein that is a translation product of the kup-1 gene in worm.


desmethylanhydrotetracycline zwitterion

A zwtterion obtained by transfer of a proton from the 2-hydroxy to the secondary amino group of desmethylanhydrotetracycline. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


description: Neurodegeneration due to 3-hydroxyisobutyryl-CoA hydrolase deficiency is characterized by delayed motor development, hypotonia and progressive neurodegeneration. To date, it has been described in four boys. The syndrome is caused by mutations affecting the two alleles of the HIBCH gene, encoding 3-hydroxyisobutyryl-CoA hydrolase. The mode of transmission has not yet been established.


inborn organic aciduria

description: An inherited disorder that affects the metabolism of any acidic compound containing carbon in a covalent linkage.


3-hydroxyisobutyric aciduria

description: 3 hydroxyisobutyric aciduria is characterized by ketoacidotic episodes, cerebral anomalies and facial dysmorphism. It is an organic aciduria that involves valine metabolism. Thirteen cases have been described in the literature so far. Transmission is thought to be autosomal recessive.


isovaleric acidemia

description: Isovaleric acidemia (IVA) is an autosomal recessively inherited organic aciduria characterized by a deficiency in isovaleryl-CoA dehydrogenase, that has wide clinical variability and that can present in infancy with acute manifestations of vomiting, failure to thrive, seizures, lethargy, a characteristic ''sweaty feet'' odor, acute pancreatitis and mild to severe developmental delay or in childhood with metabolic acidosis (brought on by prolonged fasting, an increased intake of protein-rich food or infections) and that can be fatal if not treated immediately. Chronic intermittent presentations and asymptomatic patients have also been reported.


maple syrup urine disease

description: An autosomal recessive inherited disorder caused by mutations in the BCKDHA, BCKDHB, DBT, and DLD genes. It is characterized by a deficiency of branched-chain alpha-keto acid dehydrogenase complex, leading to accumulation of metabolites in the body fluids. The name of the disease derives from the sweet odor of the urine in infants, reminiscent of maple syrup. Signs and symptoms usually appear in infancy and include lethargy and developmental delays. If untreated, it may lead to seizures, coma, and death.


glutaric acidemia type 3

description: Glutaryl-CoA oxidase deficiency is a peroxisomal disorder leading to glutaric aciduria. The prevalence is unknown. There is no distinctive phenotype associated with this disorder and one of the reported cases was asymptomatic. Transmission appears to be autosomal recessive.


description: 3-methylcrotonyl-CoA carboxylase deficiency (3-MCCD) is an inherited disorder of leucine metabolism characterized by a highly variable clinical picture ranging from metabolic crisis in infancy to asymptomatic adults.


3-methylglutaconic aciduria type 3

description: 3-methylglutaconic aciduria type III (MGA III) is an organic aciduria characterized by the association of optic atrophy and choreoathetosis with 3-methylglutaconic aciduria.


beta-ketothiolase deficiency

description: Beta-ketothiolase (T2) deficiency is a rare organic aciduria affecting ketone body metabolism and the catabolism of isoleucine and characterized by intermittent ketoacidotic episodes associated with vomiting, dyspnea, tachypnoea, hypotonia, lethargy and coma, with an onset during infancy or toddlerhood and usually ceasing by adolescence.


3-methylglutaconic aciduria type 4

description: 3-methylglutaconic aciduria (3-MGA) type IV, or unclassified 3-MGA, is a clinically heterogeneous disorder characterized by increased 3-methylglutaconic acid excretion in individuals that cannot be classified as having one of the other forms of 3-MGA (3-MGA I, II or III).


name: vitamin B12-responsive methylmalonic acidemia, type cblDv2


name: 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome

description: Any 3-methylglutaconic aciduria in which the cause of the disease is a mutation in the SERAC1 gene.


methylmalonic aciduria, cblB type

description: An autosomal recessive form of methylmalonic aciduria, caused by mutation(s) in the MMAB gene, encoding cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial.


name: methylmalonate semialdehyde dehydrogenase deficiency


maple syrup urine disease type 1A

description: A maple syrup urine disease caused by mutations in BCKDHA.


name: methylmalonic acidemia due to methylmalonyl-CoA epimerase deficiency

description: Methylmalonic acidemia due to methylmalonyl-CoA epimerase deficiency is a rare inborn error of metabolism disease characterized by mild to moderate, persistent elevation of methylmalonic acid in plasma, urine and cerebrospinal fluid. Clinical presentation may include acute metabolic decompensation with metabolic acidosis (presenting with vomiting, dehydration, confusion, hallucinations), nonspecific neurological symptoms, or may also be asymptomatic.


name: thiamine-responsive maple syrup urine disease

description: Thiamine-responsive maple syrup urine disease (thiamine-responsive MSUD) is a less severe variant of MSUD that manifests with a phenotype similar to intermediate MSUD but that responds positively to treatment with thiamine.


multiple carboxylase deficiency

description: Multiple carboxylase deficiency (MCD) is a term used to describe inborn errors of biotin metabolism characterized by reduced activities of biotin-dependent enzymes resulting in a wide spectrum of symptoms, including feeding difficulty, breathing difficulties, lethargy, seizures, skin rash, alopecia, and developmental delay.


malonic aciduria

description: Malonic aciduria is a metabolic disorder caused by deficiency of malonyl-CoA decarboxylase (MCD).


name: methylmalonic aciduria and homocystinuria

description: An inborn error of vitamin B12 (cobalamin) metabolism characterized by megaloblastic anemia, lethargy, failure to thrive, developmental delay, intellectual deficit and seizures. There are four complementation classes of cobalamin defects (cblC, cblD, cblF and cblJ) that are responsible for methylmalonic acidemia - homocystinuria (methylmalonic acidemia - homocystinuria cblC, cblD cblF and cblJ).


name: vitamin B12-unresponsive methylmalonic acidemia type mut0

description: Vitamin B12-unresponsive methylmalonic acidemia type mut0 is an inborn error of metabolism characterized by recurrent ketoacidotic comas or transient vomiting, dehydration, hypotonia and intellectual deficit, which does not respond to administration of vitamin B12.


pyruvate dehydrogenase E3 deficiency

description: Pyruvate dehydrogenase E3 deficiency is a very rare subtype of pyruvate dehydrogenase deficiency (PDHD) characterized by either early-onset lactic acidosis and delayed development, later-onset neurological dysfunction or liver disease.


methylmalonic aciduria, cblA type

description: An autosomal recessive form of methylmalonic aciduria, caused by mutation(s) in the MMAA gene, encoding MMAA protein.


name: combined malonic and methylmalonic acidemia

description: Combined malonic and methylmalonic acidemia is a rare inborn error of metabolism characterized by elevation of malonic acid (MA) and methylmalonic acid (MMA) in body fluids, with higher levels of MMA than MA. CMAMMA presents in childhood with metabolic acidosis, developmental delay, dystonia and failure to thrive or in adulthood with seizures, memory loss and cognitive decline.


name: methylmalonic acidemia with homocystinuria, type cblX


3-methylglutaconic aciduria type 5

description: A syndrome characterized by severe early onset (before the age of three years) dilated cardiomyopathy (DCM) with conduction defects (long QT syndrome), non-progressive cerebellar ataxia, testicular dysgenesis, and 3-methylglutaconic aciduria.


maple syrup urine disease type 1B

description: A maple syrup urine disease caused by mutations in BCKDHB.


intermediate maple syrup urine disease

description: Intermediate maple syrup urine disease (intermediate MSUD) is a milder form of MSUD characterized by persistently raised branched-chain amino acids (BCAAs) and ketoacids, but fewer or no acute episodes of decompensation.


name: methylmalonic aciduria and homocystinuria type cblF

description: A form of methylmalonic acidemia with homocystinuria, an inborn error of vitamin B12 (cobalamin) metabolism characterized by megaloblastic anemia, lethargy, failure to thrive, developmental delay, intellectual deficit and seizures. The disorder is caused by mutations in the LMBRD1 gene (6q13) and is transmitted in an autosomal recessive manner.


intermittent maple syrup urine disease

description: Intermittent maple syrup urine disease (intermittent MSUD) is a mild form of MSUD where patients (when well) are asymptomatic with normal levels of branched-chain amino acids (BCAAs) but with catabolic stress are at risk of acute decompensation with ketoacidosis, which can lead to cerebral edema and coma if untreated.


name: 3-methylcrotonyl-CoA carboxylase 1 deficiency

description: Any 3-methylcrotonyl-CoA carboxylase deficiency in which the cause of the disease is a mutation in the MCCC1 gene.


3-methylglutaconic aciduria type 1

description: 3-methylglutaconic aciduria (3-MGA) type I is an inborn error of leucine metabolism with a variable clinical phenotype ranging from mildly delayed speech to psychomotor retardation, coma, failure to thrive, metabolic acidosis and dystonia.


holocarboxylase synthetase deficiency

description: A life-threatening early-onset form of multiple carboxylase deficiency, an inborn error of biotin metabolism, that, if untreated, is characterized by vomiting, tachypnea, irritability, lethargy, exfoliative dermatitis, and seizures that can worsen to coma.


name: 3-methylcrotonyl-CoA carboxylase 2 deficiency

description: Any 3-methylcrotonyl-CoA carboxylase deficiency in which the cause of the disease is a mutation in the MCCC2 gene.


name: methylmalonic acidemia due to transcobalamin receptor defect

description: Methylmalonic aciduria due to transcobalamin receptor defect is a rare metabolite absorption and transport disorder characterized by a moderate increase of methylmalonic acid (MMA) in the blood and urine due to decreased cellular uptake of cobalamin resulting from decreased transcobalamin receptor function. Patients are usually asymptomatic however, screening reveals increased C3-acylcarnitine and MMA in plasma. Serum homocysteine levels may vary from normal to moderately elevated and retinal vascular occlusive disease, resulting in severe visual loss, has been reported.


biotinidase deficiency

description: Biotinidase deficiency is a late-onset form of multiple carboxylase deficiency, an inborn error of biotin metabolism that, if untreated, is characterized by seizures, breathing difficulties, hypotonia, skin rash, alopecia, hearing loss and delayed development.


classic maple syrup urine disease

description: Classic maple syrup urine disease (classic MSUD) is the most severe and probably common form of MSUD characterized by a maple syrup odor in the cerumen at birth, poor feeding, lethargy and focal dystonia, followed by progressive encephalopathy and central respiratory failure if untreated.


name: methylmalonic acidemia with homocystinuria, type cblJ

description: An autosomal recessive form of combined methylmalonic aciduria and homocystinuria, caused by mutation(s) in the ABCD4 gene, encoding lysosomal cobalamin transporter ABCD4.


glutaryl-CoA dehydrogenase deficiency

description: Glutaryl-CoA dehydrogenase (GCDH) deficiency (GDD) is an autosomal recessive neurometabolic disorder clinically characterized by encephalopathic crises resulting in striatal injury and a severe dystonic dyskinetic movement disorder.


maple syrup urine disease type 2

description: A maple syrup urine disease caused by mutations in DBT.


name: vitamin B12-unresponsive methylmalonic acidemia type mut-

description: Vitamin B12-unresponsive methylmalonic acidemia type mut- is an inborn error of metabolism characterized by recurrent ketoacidotic comas or transient vomiting, dehydration, hypotonia and intellectual deficit, which does not respond to administration of vitamin B12.


3-hydroxy-3-methylglutaric aciduria

description: 3-hydroxy-3-methylglutaric aciduria (3HMG) is an organic aciduria, due to deficiency of 3-hydroxy-3-methylglutaryl-CoA-lyase (a key enzyme in ketogenesis and leucine metabolism) usually presenting in infancy with episodes of metabolic decompensation triggered by periods of fasting or infections, which when left untreated are life-threatening and may lead to neurological sequelae.


name: vitamin B12-responsive methylmalonic acidemia

description: Vitamin B12-responsive methylmalonic acidemia (MA) is an inborn error of vitamin B12 (cobalamin) metabolism characterized by recurrent ketoacidotic comas or transient vomiting, dehydration, hypotonia and intellectual deficit, which responds to vitamin B12. There are three types: cblA, cblB and cblD-variant 2 (cblDv2).


night blue

An iminium salt composed of 4-{(4-anilinonaphthalen-1-yl)[4-(diethylamino)phenyl]methylidene}-N,N-diethylcyclohexa-2,5-dien-1-iminium and chloride ions in a 1:1 ratio.


glutamate decarboxylase 1 isoform 1

A glutamate decarboxylase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48318-1 or a 1:1 ortholog thereof.


name: glutamate decarboxylase 1 isoform 1 (mouse)

description: A glutamate decarboxylase 1 isoform 1 that is encoded in the genome of mouse.


name: glutamate decarboxylase 1 isoform 1 (rat)

description: A glutamate decarboxylase 1 isoform 1 that is encoded in the genome of rat.


name: DNA repair protein RAD50 isoform 3 (mouse)

description: A DNA repair protein RAD50 isoform 3 that is encoded in the genome of mouse.


name: microcephaly-thin corpus callosum-intellectual disability syndrome

description: Microcephaly-thin corpus callosum-intellectual disability syndrome is a rare, genetic, syndromic intellectual disability disease characterized by progressive postnatal microcephaly and global developmental delay, as well as moderate to profound intellectual disability, difficulty or inability to walk, pyramidal signs (including spasticity, hyperreflexia and extensor plantar response) and thin corpus callosum revealed by brain imaging. Ophthalmologic signs (including nystagmus, strabismus and abnormal retinal pigmentation), foot deformity and genital anomalies may also be associated.


name: MBT domain-containing protein 1 isoform h1 (human)

description: An MBT domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05BQ5-1.


An organic heterobicyclic compound that is 7,7a-dihydrocyclopenta[b]pyran-6(2H)-one substituted by a hydroxy group at position 5 and a prop-2-en-1-ylidene group at position 7 (the E isomer). Isolated from the sponge Ulosa and ascidian Diplosoma virens, it exhibits antimicrobial activity and toxicity against HCT116 cells (human colorectal cancer cells) by triggering apoptotic cell death.


name: probable pleckstrin homology domain-containing family N member 1 isoform m3 (mouse)

description: A probable pleckstrin homology domain-containing family N member 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C886-3.


name: dynein axonemal heavy chain 17 isoform h4 (human)

description: A dynein axonemal heavy chain 17 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UFH2-4.


name: Unresectable Pleural Sarcomatoid Mesothelioma

description: Pleural sarcomatoid mesothelioma that is not amenable to surgical resection.


Pleural Desmoplastic Mesothelioma

description: Malignant mesothelioma that arises from the pleura. It is characterized by the presence of dense collagenized stroma occupying at least 50% of the tumor. The malignant cells are arranged in a vague storiform pattern.


name: Unresectable Peritoneal Epithelioid Mesothelioma

description: Peritoneal epithelioid mesothelioma that is not amenable to surgical resection.


name: Unresectable Paratesticular Sarcomatoid Mesothelioma

description: Paratesticular sarcomatoid mesothelioma that is not amenable to surgical resection.


Paratesticular Epithelioid Mesothelioma

description: A rare malignant mesothelioma arising from the tunica vaginalis. It is characterized by the presence of cells with epithelioid morphology. The epithelioid cells usually have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, or sheet-like patterns.


Desmoplastic mesothelioma

description: A malignant neoplasm arising from mesothelial cells. It is characterized by the presence of a dense collagenous tissue and atypical neoplastic cells. Sarcomatoid features, collagenous necrosis, and infiltration of muscle and adipose tissue may be present. It occurs in the pleura and less commonly in the peritoneum.


Peritoneal Epithelioid Mesothelioma

description: Malignant mesothelioma that arises from the peritoneum. It is characterized by the presence of cells with epithelioid morphology. The epithelioid cells usually have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, or sheet-like patterns.


malignant biphasic mesothelioma

description: A malignant neoplasm arising from mesothelial cells in the pleura. It is characterized by the presence of neoplastic epithelioid cells and sarcomatoid features.


name: Unresectable Paratesticular Epithelioid Mesothelioma

description: Paratesticular epithelioid mesothelioma that is not amenable to surgical resection.


Peritoneal Biphasic Mesothelioma

description: Malignant mesothelioma that arises from the peritoneum. It is characterized by the presence of epithelioid and sarcomatoid components, with each component representing at least 10% of the tumor.


name: Unresectable Pleural Biphasic Mesothelioma

description: Pleural biphasic mesothelioma that is not amenable to surgical resection.


name: Unresectable Paratesticular Biphasic Mesothelioma

description: Paratesticular biphasic mesothelioma that is not amenable to surgical resection.


Paratesticular Sarcomatoid Mesothelioma

description: A rare malignant mesothelioma arising from the tunica vaginalis. It is characterized by the presence of spindle cells. Anaplastic morphologic features and multinucleated malignant cells may also be seen.


name: Unresectable Peritoneal Sarcomatoid Mesothelioma

description: Peritoneal sarcomatoid mesothelioma that is not amenable to surgical resection.


pleural biphasic mesothelioma

description: Malignant mesothelioma that arises from the pleura. It is characterized by the presence of epithelioid and sarcomatoid components, with each component representing at least 10% of the tumor.


Advanced Epithelioid Mesothelioma

description: Epithelioid mesothelioma that has spread extensively to other anatomic sites or is no longer responding to treatment.


sarcomatoid mesothelioma

description: A diffuse malignant mesothelioma arising from the pleura and less often the peritoneum. It is characterized by the presence of spindle cells. Anaplastic morphologic features and multinucleated malignant cells may also be seen.


pleural sarcomatoid mesothelioma

description: Malignant mesothelioma that arises from the pleura and is characterized by the presence of spindle-shaped cells forming fascicles, or that are distributed haphazardly resembling a sarcoma.


Paratesticular Biphasic Mesothelioma

description: A rare malignant mesothelioma arising from the tunica vaginalis. It is characterized by the presence of epithelioid and sarcomatoid components, with each component representing at least 10% of the tumor.


name: Unresectable Pleural Epithelioid Mesothelioma

description: Pleural epithelioid mesothelioma that is not amenable to surgical resection.


Recurrent Epithelioid Mesothelioma

description: The reemergence of epithelioid mesothelioma after a period of remission.


pleural epithelioid mesothelioma

description: Malignant mesothelioma that arises from the pleura and is characterized by the presence of cells with epithelioid morphology. The epithelioid cells usually have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, or sheet-like patterns.


name: Unresectable Peritoneal Biphasic Mesothelioma

description: Peritoneal biphasic mesothelioma that is not amenable to surgical resection.


Peritoneal Sarcomatoid Mesothelioma

description: Malignant mesothelioma that arises from the peritoneum. It is characterized by the presence of spindle cells. Anaplastic morphologic features and multinucleated malignant cells may also be seen.


malignant epithelioid mesothelioma

description: A malignant neoplasm arising from mesothelial cells in the pleura. It is characterized by the presence of neoplastic cells with an epithelioid appearance. In the majority of cases, the neoplastic epithelioid cells lack significant cytologic atypia; mitotic figures are infrequently seen. In a minority of cases, the neoplastic cells are poorly differentiated and there is evidence of nuclear atypia and increased mitotic activity.


cytochrome b deaminated 1 (human)

A cytochrome b (human) that has been deaminated on the residue at the position equivalent to Asn-85 of the amino acid sequence represented by UniProtKB:P00156. UniProtKB:P00156, Asn-85, MOD:00684.


name: YCBB_ECOLI Probable L,D-transpeptidase YcbB (sprot)

description: A probable L,D-transpeptidase YcbB that is encoded in the genome of Escherichia coli K-12.


nectriapyrone

A member of the class of nectriapyrones that is pyran-2-one which is substituted at positions 3, 4, and 6 by methyl, methoxy, and but-2-en-2-yl groups, respectively in which the butenyl substituent has E configuration. A fungal metabolite that has been induced in the rice blast fungus Pyricularia oryzae by overexpression of a polyketide synthase gene (NEC1) and an O-methyltransferase gene (NEC2).


semaphorin-3F isoform A (mouse)

A semaphorin-3F isoform 2 that is encoded in the genome of mouse.


N-acetyl-L-methionyl-L-phenylalanine

A dipeptide obtained by formal condensation of the carboxy group of N-acetyl-L-methionine with the amino group of L-phenylalanine.


name: PHD finger protein 11 isoform m2 (mouse)

description: A PHD finger protein 11 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A6H5X4-2.


name: phosphatidate cytidylyltransferase, mitochondrial acetylated 1 (human)

description: A phosphatidate cytidylyltransferase, mitochondrial (human) that has been acetylated on the residue at the position equivalent to Lys-206 of the amino acid sequence represented by UniProtKB:Q96BW9-1. Example: UniProtKB:Q96BW9-1, Lys-206, MOD:00723.


PRS42_MOUSE Serine protease 42 (sprot)

A putative serine protease 42 that is encoded in the genome of mouse.


name: PPR83_ARATH Putative pentatricopeptide repeat-containing protein At1g56570 (sprot)

description: A protein that is a translation product of the PCMP-E64 gene in Arabidopsis thaliana.


name: eukaryotic translation initiation factor 5 isoform b (worm)

description: A eukaryotic translation initiation factor 5 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q22918-2.


name: F149B_RAT Primary cilium assembly protein FAM149B1 (sprot)

description: A primary cilium assembly protein FAM149B1 that is encoded in the genome of rat.


name: primary cilium assembly protein FAM149B1

description: A protein that is a translation product of the human FAM149B1 gene or a 1:1 ortholog thereof.


name: primary cilium assembly protein FAM149B1 cysteinylated 1 (human)

description: A primary cilium assembly protein FAM149B1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-131 of the amino acid sequence represented by UniProtKB:Q96BN6-1. Example: UniProtKB:Q96BN6-1, Cys-131, MOD:00765.


name: F149B_HUMAN Primary cilium assembly protein FAM149B1 (sprot)

description: A primary cilium assembly protein FAM149B1 that is encoded in the genome of human.


name: primary cilium assembly protein FAM149B1 isoform m3 (mouse)

description: A primary cilium assembly protein FAM149B1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6NSV7-3.


name: primary cilium assembly protein FAM149B1 isoform m4 (mouse)

description: A primary cilium assembly protein FAM149B1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6NSV7-4.


name: primary cilium assembly protein FAM149B1 isoform m6 (mouse)

description: A primary cilium assembly protein FAM149B1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6NSV7-6.


name: primary cilium assembly protein FAM149B1 isoform m5 (mouse)

description: A primary cilium assembly protein FAM149B1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6NSV7-5.


F149B_DANRE Protein FAM149B1 (sprot)

A primary cilium assembly protein FAM149B1 that is encoded in the genome of zebrafish.


name: primary cilium assembly protein FAM149B1 isoform h2 (human)

description: A primary cilium assembly protein FAM149B1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96BN6-2.


name: primary cilium assembly protein FAM149B1 isoform m1 (mouse)

description: A primary cilium assembly protein FAM149B1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6NSV7-1.


name: primary cilium assembly protein FAM149B1 isoform m2 (mouse)

description: A primary cilium assembly protein FAM149B1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6NSV7-2.


name: F149B_MOUSE Primary cilium assembly protein FAM149B1 (sprot)

description: A primary cilium assembly protein FAM149B1 that is encoded in the genome of mouse.


name: primary cilium assembly protein FAM149B1 isoform h1 (human)

description: A primary cilium assembly protein FAM149B1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96BN6-1.


toxic epidermal necrolysis

description: Toxic epidermal necrolysis (TEN) is an acute and severe skin disease with clinical and histological features characterized by the destruction and detachment of the skin epithelium and mucous membranes.


name: DPP10_MOUSE Inactive dipeptidyl peptidase 10 (sprot)

description: An inactive dipeptidyl peptidase 10 that is encoded in the genome of mouse.


name: calcium uptake protein 1, mitochondrial isoform 1 (rat)

description: A calcium uptake protein 1, mitochondrial isoform 1 that is encoded in the genome of rat.


AMPD1_MOUSE AMP deaminase 1 (sprot)

An AMP deaminase 1 that is encoded in the genome of mouse.


name: vesicle transport through interaction with t-SNAREs homolog 1A isoform 2 (human)

description: A vesicle transport through interaction with t-SNAREs homolog 1A isoform 2 that is encoded in the genome of human.


name: LPPY_ECOLI pyr operon leader peptide (sprot)

description: A protein that is a translation product of any of the 2 copies of the pyrL gene in Escherichia coli K-12.


oculocutaneous albinism type 4

description: Oculocutaneous albinism type 4 (OCA4) is a type of OCA characterized by varying degrees of skin and hair hypopigmentation, numerous ocular changes and misrouting of the optic nerves at the chiasm.


negative regulation of p38MAPK cascade

description: Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade.


A lignan that is 3,4-dihydronaphthalen-1(2H)-one substituted by a hydroxy group at position 7, a methoxy group at position 6 and methyl groups at positions 2 and 3 (the 2R,3S-stereoisomer). It has been isolated from the bark of Machilus robusta.


name: NudC domain-containing protein 3 methylated 1 (human)

description: A NudC domain-containing protein 3 (human) that has been methylated on the residue at the position equivalent to Cys-260 of the amino acid sequence represented by UniProtKB:Q8IVD9. UniProtKB:Q8IVD9, Cys-260, MOD:00660.


name: coiled-coil domain-containing protein 68 isoform m2 (mouse)

description: A coiled-coil domain-containing protein 68 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BVC4-2.


name: mesonephric nephron tubule epithelial cell

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any epithelial cell that is part of some mesonephric nephron tubule.


name: ciliary microtubule associated protein 1A isoform 1 (human)

description: A ciliary microtubule associated protein 1A isoform 1 that is encoded in the genome of human.


name: inner membrane ABC transporter permease protein YcjO

description: A protein that is a translation product of the Escherichia coli K-12 ycjO gene or a 1:1 ortholog thereof.


name: YCJO_ECOLI Inner membrane ABC transporter permease protein YcjO (sprot)

description: An inner membrane ABC transporter permease protein YcjO that is encoded in the genome of Escherichia coli K-12.


name: hydroxymethylglutaryl-CoA synthase, mitochondrial, transit peptide removed form (human)

description: A hydroxymethylglutaryl-CoA synthase, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P54868, 38-508.


name: sodium/potassium-transporting ATPase subunit alpha-4 methylated 2 (human)

description: A sodium/potassium-transporting ATPase subunit alpha-4 (human) that has been methylated on the residue at the position equivalent to Glu-295 of the amino acid sequence represented by UniProtKB:Q13733-1. Example: UniProtKB:Q13733-1, Glu-295, MOD:00713.