name: Hodgkin's disease mixed cellularity stage I site unspecified

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Vulvar Warty Carcinoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A squamous cell carcinoma that arises from the vulva and is characterized by the presence of a warty surface and cellular changes that are caused by human papillomavirus infection.


name: Appendix Enterochromaffin Cell Serotonin-Producing Neuroendocrine Tumor

description: A well differentiated neuroendocrine tumor arising from the wall of the appendix.  It is characterized by the presence of neoplastic cells forming round solid nests and occasionally glandular structures.  The majority of the cases are asymptomatic, and they are found incidentally in appendectomy specimens.  The majority of the tumors are located in the distal end of the appendix and they are enterochromaffin-cell carcinoid tumors producing serotonin.  Most cases show morphologic evidence of appendiceal wall and lymphatic vessel invasion by tumor cells.  Despite the morphologic evidence of invasion, appendiceal carcinoid tumors only infrequently produce lymph node or distant metastases.


Solid Neoplasm

description: A benign or malignant neoplasm arising from tissues that do not include fluid areas.  Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma).  Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors.


Laboratory Test Result

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: The outcome of a laboratory test.


Intimal dissection

description: A dissection of an artery that occurs though a tear in the inner lining of the blood vessel.


Advanced Pancreatobiliary Carcinoma

description: A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Testicular Yolk Sac Tumor, Postpubertal-Type

description: Testicular yolk sac tumor that is associated with germ cell neoplasia in situ and usually occurs as a component of mixed germ cell tumor. Pure postpubertal-type testicular yolk sac tumor is exceedingly rare.


Paratesticular Mesothelial Neoplasm

description: A mesothelial neoplasm that arises from the paratesticular structures. It includes adenomatoid tumor, well differentiated papillary mesothelial tumor, and malignant mesothelioma.


Tissue Kallikrein Deficiency

description: A disorder characterized by the partial or complete absence of tissue-type kallikrein activity in the tissues and glandular secretions where it is normally present.


Cutaneous Melanoma by AJCC v6 Stage

description: A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v6 classification system.


Alpha trait thalassemia

description: A condition in which a person has reduced protein production from two of the four alpha-globin alleles.


name: Glandular Cell Intraepithelial Neoplasia


Virus-Related Lymphoma

description: Lymphoma that is caused by a virus infection.


Atypical hyperplasia of breast

description: A general term that refers to atypical hyperplastic proliferations of the epithelial cells in the breast parenchyma.  Examples include atypical ductal hyperplasia, atypical lobular hyperplasia, and columnar cell hyperplasia with atypia.


name: Endocrine mucin-producing sweat gland carcinoma

description: A rare, low-grade sweat gland carcinoma with neuroendocrine differentiation. It usually arises on the eyelids and periorbital skin. It affects mostly older individuals. Women are affected more frequently than men. Morphologically, it is characterized by well-demarcated nodules with cystic, papillary, or cribriform architectural patterns. The neoplastic cells are small to intermediate polygonal to round cells. Small amounts of intracellular or extracellular mucin are present. In some cases, this carcinoma is a precursor of mucinous carcinoma.


Refractory Non-Cutaneous Melanoma

description: Non-cutaneous melanoma that is resistant to treatment.


benign fibrous histiocytoma of bone

description: A rare, benign neoplasm usually arising from the non-metaphyseal regions of long bones or pelvis. It is characterized by the presence of fibroblastic spindle cells arranged in a whorled storiform pattern, osteoclast-like giant cells, foam cells, inflammatory cells, hemosiderin deposition and stromal hemorrhage.


Female sexual arousal disorder

description: A disorder characterized by a recurrent or persistent inability to attain or maintain until completion of sexual activity an adequate physical response of sexual excitement, consisting of vasocongestion in the pelvis, vaginal lubrication and expansion, and swelling of the external genitalia.


Solid Alveolar Rhabdomyosarcoma

description: A morphologic variant of alveolar rhabdomyosarcoma.  It is characterized by the presence of a solid growth pattern and the absence of fibrovascular stroma.


Stage IVB Vaginal Cancer AJCC v6 and v7

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Spinal Cord Infarct During Birth

description: Ischemic necrosis of the spinal cord due to spinal artery occlusion during the birthing process.


Ptosis

description: A condition in which an organ or body tissue drops or bulges out of place.


Metastatic Meningioma

description: A meningioma that has spread from its original site of growth to another anatomic site.


Residual schizophrenia

description: A subtype of schizophrenia in which the individual has suffered an episode of schizophrenia but there are no longer any delusions, hallucinations, disorganized speech or behavior. Residual symptoms are seen in the form of negative symptoms (such as flat affect or avolition) or attenuated positive symptoms (such as odd beliefs).


Panniculitis, Peritoneal

description: A disorder characterized by chronic inflammation and fibrosis of the adipose tissues in the peritoneal cavity.


name: Stage III Ampulla of Vater Cancer AJCC v7

description: Stage III includes: T4, Any N, M0. T4: Tumor invades peripancreatic soft tissues or other adjacent organs or structures other than the pancreas.  M0: No distant metastasis. (from AJCC 7th Ed.)


HIV Encephalopathy

description: Encephalopathy that is associated with human immunodeficiency virus (HIV) infection.


Chemical conjunctivitis

description: Inflammation of the conjunctiva in a newborn due to chemical irritation which was acquired postnatally from iatrogenic causes.


Pancreatic Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the pancreas. The Ki-67 index is higher than 20%.


Polygenic Obesity

description: Obesity associated with variations in multiple genes.


Port Site Infection

description: An infection at an anatomic location used for vascular access.


name: Stage III Appendix Neuroendocrine Tumor AJCC v7

description: Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor directly invades other adjacent organs or structures, e.g., abdominal wall and skeletal muscle.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Chronic Myelomonocytic Leukemia-2

description: A chronic myelomonocytic leukemia characterized by the presence of 10-19 percent blasts in the bone marrow and 5-19 percent blasts in the peripheral blood or by the presence of Auer rods regardless of the blasts count.


Grade 2 Diffuse Follicular Lymphoma

description: A follicular lymphoma with diffuse pattern characterized by the presence of 6-15 centroblasts per 40 high-power fields.


Presyncope Related to COVID-19

description: Presyncope in a patient with probable or confirmed acute COVID-19.


name: Ann Arbor Stage II AIDS-Related Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Unresectable Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that is not amenable to surgical resection.


Dissociative Hysteria

description: A disorder characterized by sudden, unexpected travel away from one's home or place of work accompanied by an inability to recall one's past; the individual is confused about his or her personal identity and may assume a new identity.


Stage IIA Bone Cancer AJCC v8

description: Stage IIA includes: T1, N0, M0, G2 or G3. T1: Tumor measuring 8 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


Proximal Gastric Adenocarcinoma

description: A gastric adenocarcinoma that arises from the proximal part of the stomach.


Aplastic anemia due to drugs

description: A state of bone marrow suppression and failure that is caused by a cytotoxic or adverse immunologic response to a drug treatment, leading to a failure of production of red blood cells, white cells and platelets.


Fallopian Tube Cancer by AJCC v6 Stage

description: A term that refers to the staging of fallopian tube carcinoma according to the American Joint Committee on Cancer, 6th edition.


Fistula of gallbladder

description: An abnormal communication between the gallbladder and another organ or cavity.


Aorticopulmonary Septal Defect

description: A congenital heart malformation characterised by incomplete separation of the truncus arteriosus and the aorticopulmonary trunk, resulting in communication between the aorta and pulmonary trunk.


name: High Grade Gastric Intraepithelial Neoplasia

description: A gastric intraepithelial lesion characterized by the presence of neoplastic cells that are cuboidal with a high nucleus to cytoplasmic ratio, prominent nucleoli, significant architectural changes, and increased number of mitotic figures.


Early Inflammatory Arthritis

description: Early stages of inflammatory arthritis, when the underlying diagnosis is uncertain, usually little or no joint damage has occurred. Treatment may alter the disease course (e.g., potentially avert progression to full RA or other diagnosis).


name: FIGO Grade 3 Endometrial Mucinous Adenocarcinoma

description: A primary mucinous adenocarcinoma of the endometrium that contains more than 50% non-squamous solid areas.


Acute on chronic systolic heart failure

description: Acute decompensation of chronic systolic congestive heart failure.


Diffuse Meningeal Melanocytic Neoplasm

description: A diffuse proliferation of melanocytes that affects the leptomeninges. This category includes melanocytosis and melanomatosis.


name: Adult Acute Myeloid Leukemia with Minimal Differentiation

description: An acute myeloid leukemia with minimal differentiation occurring in adults.


name: Non-Neoplastic Respiratory System Disorder

description: A non-neoplastic disorder that affects the respiratory system.  Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, tracheitis, and tracheal agenesis.


name: Metastatic Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Distant metastases present at diagnosis. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Prostate Ductal Adenocarcinoma, Cribriform Pattern

description: A prostate ductal adenocarcinoma characterized by the presence of neoplastic large back-to-back glands with slit-like lumens.


Adult Pineocytoma

description: A pineocytoma occurring in adults.


name: Recurrent Neoplastic Post-Transplant Lymphoproliferative Disorder

description: The reemergence of neoplastic post-transplant lymphoproliferative disorder after a period of remission.


name: Unresectable Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that is not amenable to surgical resection.


name: Unresectable Extrapulmonary Neuroendocrine Carcinoma

description: Extrapulmonary neuroendocrine carcinoma that is not amenable to surgical resection.


description: An epithelioid hemangioendothelioma that is not amenable to surgical resection.


Fallopian Tube Cancer by AJCC v8 Stage

description: A term that refers to the staging of fallopian tube cancer according to the American Joint Committee on Cancer, 8th edition.


name: Adenocarcinoma with spindle cell metaplasia

description: An invasive adenocarcinoma characterized by focal or extensive transformation of the malignant glandular cells to spindle-shaped cells.


Unresectable Cervical Carcinoma

description: Cervical carcinoma that is not amenable to surgical resection.


name: Squamous cell carcinoma in situ with questionable stromal invasion

description: A malignant epithelial neoplasm involving all the layers of the squamous epithelium, but it is not certain if it is confined to the squamous epithelium or it has invaded the basement membrane and the underlying stroma.


Stage II Uterine Corpus Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Cancer-related Cognitive Dysfunction

description: The effects of cancer and its treatments on cognitive processes.


Prostate cancer stage D

description: Metastatic disease.


Polyp of esophagus

description: A benign intraluminal polypoid neoplasm of the esophagus.  It includes the squamous papilloma and the giant fibrovascular polyp.


S-sulfo-L-cysteine

An S-substituted L-cysteine where the S-substituent is specified as a sulfo group.


thiosulfate

An ester of thiosulfuric acid.


S-alkyl thiosulfate

An organic thiosulfate compound having an S-alkyl substituent.


S-2-(dimethylamino)ethyl thiosulfate

An S-alkyl thiosulfate having 2-(dimethylamino)ethyl as the alkyl group.


organic thiosulfate

The organic ester of thiosulfuric acid.


A phenol that is 2-phenylethanol in which the phenyl ring is substituted at position 2 by a hydroxy group.


2-deoxy-D-ribose 5-phosphate

The 5-O-phosphono derivative of 2-deoxy-D-ribose.


2-deoxy-D-ribofuranose 5-phosphate

The furanose form of 2-deoxy-D-ribose 5-phosphate.


iodamide

A benzoic acid compound having iodo substituents at the 2-, 4- and 6-positions, an acetamido substituent at the 3-position and an acetamidomethyl substituent at the 5-position.


A linear amino tetrasaccharide comprising N-acetyl-alpha-neuraminyl, beta-D-galactosyl, N-acetyl-beta-D-glucosaminyl and D-mannose residues linked sequentially (2->6), (1->4) and (1->2).


SYRINGIC ACID

A dimethoxybenzene that is 3,5-dimethyl ether derivative of gallic acid.


azanigerone D

An azaphilone that is the ester obtained by formal condensation of the carboxy group of 2,4-dimethylhexanoic acid with the tertiary hydroxy group of 7-hydroxy-7-methyl-6,8-dioxo-2,6,7,8-tetrahydroisoquinoline-3-carboxylic acid.


dUMP 5'-end residue

The 5'-end bound-monomer of a uridylyl-5'-monophosphoric acid that is part of a nucleic acid.


An amino trisaccharide consisting of beta-lactose and 2-acetamido-2-deoxy-alpha-D-galactopyranose joined by a (1->6) glycosidic bond.


A 2,6-diaminopurine that is an analogue of abacavir in which the cyclopropylamino group at position 6 of the purine moiety is replaced by a 3-methoxyazetidin-1-yl group. One of a series of synthesised abacavir analogues with antiviral activity found to stimulate IFN-gamma secretion in abacavir-responsive clones.


The Z (syn) isomer of testosterone-3-CMO-Hist.


A chlorophenylmethane that is methane in which two of the hydrogens have been replaced by p-chlorophenyl groups.


chlorophenylmethane

A chlorohydrocarbon that is phenylmethane substituted by a chloro group at unspecified position.


name: 4-[[7-[(4-fluorophenyl)methyl]-1,3-dimethyl-2,6-dioxo-8-purinyl]methyl]-1-piperazinecarboxylic acid ethyl ester


name: 2-[4-[[(3,4-dichlorophenyl)-oxomethyl]amino]phenyl]-3,3,3-trifluoro-2-hydroxypropanoic acid ethyl ester


name: 3-oxo-2-[(6-oxo-1-phenyl-3-pyridazinyl)oxy]butanoic acid ethyl ester


name: 4-chloro-1-methyl-5-pyrazolo[3,4-b]pyridinecarboxylic acid ethyl ester


desulfated gastrin-17

One of the primary forms of gastrin that is a 17-membered peptide consisting of Glp, Gly, Pro, Trp, Leu, Glu, Glu, Glu, Glu, Glu, Ala, Tyr, Gly, Trp, Met, Asp and Phe-NH2 residues joined in sequence.


One of the primary forms of gastrin that is a 14-membered peptide consisting of Trp, Leu, Glu, Glu, Glu, Glu, Glu, Ala, Tyr, Gly, Trp, Met, Asp and Phe residues joined in sequence.


One of the primary forms of gastrin that is a 34-membered peptide consisting of Gln, Leu, Gly, Pro, Gln, Gly, Pro, Pro, His, Leu, Val, Ala, Asp, Pro, Ser, Lys, Lys, Gln, Gly, Pro, Trp, Leu, Glu, Glu, Glu, Glu, Glu, Ala, Tyr, Gly, Trp, Met, Asp and Phe residues joined in sequence.


poly(L-lysine) macromolecule

A macromolecule composed of repeating L-lysyl units joined via 1,6-amide linkages.


A trans-1,2-dihydronaphthalene-1,2-diol with a (1R,2R)-configuration.


The (1S,2S)-isomer of trans-1,2-dihydronaphthalene-1,2-diol.


cefpodoxime proxetil

The 1-[(isopropoxycarbonyl)oxy]ethyl (proxetil) ester prodrug of cefpodoxime. After swallowing, hydrolysis of the ester group occurs in the intestinal epithelium, to release active cefpodoxime in the bloodstream. It is used to treat acute otitis media, pharyngitis, and sinusitis.


A macromolecule composed of repeating 2-(diisopropylamino)ethyl isobutyrate units.


METHAMPHETAMINE HYDROCHLORIDE

A hydrochloride having methamphetamine as the base component.


An alpha-oxyketone that consists of propiophenone bearing an alpha-hydroxy substituent.


N(4)-methyl-L-asparagine residue

An alpha-amino-acid residue derived from N(4)-methyl-L-asparagine.


A proline derivative having a 2,4-dinitrophenyl substituent on nitrogen.


angelic acid

The (Z)-isomer of 2-methylbut-2-enoic acid. It is found in plant species of the family Apiaceae.


PAROMAMINE

An aminoglycoside that is 4alpha,6alpha-diaminocyclohexane-1beta,2alpha,3beta-triol in which the pro-R hydroxy group has been converted into its 2-amino-alpha-D-glucoside derivative.


zuranolone

A 3-hydroxy steroid that is 5beta-19-norpregnane substituted by hydroxy, methyl, oxo, and 4-cyano-1H-pyrazol-1-yl groups at positions 3, 3, 20 and 21, respectively. It is a positive allosteric modulator of GABAA receptor developed by Sage Therapeutics and Biogen for the treatment of postpartum depression in adults.


2-iodobenzoyl group

The aroyl group formed by loss of -OH from the carboxy group of 2-iodobenzoic acid.


19-O-acetylchaetoglobosin A

A cytochalasan alkaloid that is the acetyl derivative of chaetoglobosin A. It has been isolated from Chaetomium globosum and Chaetomium brasiliense.


A 3beta-sterol that consists of 24-methylcholest-6-en-3beta-ol with a peroxy group between positions 5 and 8 and a methylene group between positions 22 and 23. An antineoplastic agent isolated from  Sinularia sp.


captafol

A dicarboximide that captan in which the trichloromethyl group is replaced by a 1,1,2,2-tetrachloroethyl group. A broad-spectrum fungicide used to control diseases in fruit and potatoes, it is no longer approved for use in the European Community.


An organic cation that is the conjugate acid of ritlecitinib resulting from the protonation of the nitrogen in the pyrrolopyrimidine ring; Major species at pH 7.3.


An oligosaccharide sulfate consisting of 2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid and 2-acetamido-2-deoxy-alpha-D-glucopyranose residues joined in sequence by a (1->4) glycosidic linkage.


A hydrobromide salt prepared from N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol and one equivalent of hydrogen bromide. Selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.


1,2,3,6-tetrahydrophthalic anhydride

A cyclic dicarboxylic anhydride that is 1,3,3a,4,7,7a-hexahydro-2-benzofuran carrying oxo groups at positions 1 and 3.


methylhexahydrophthalic anhydride

A cyclic dicarboxylic anhydride that is the cyclic anhydride of methylhexahydrophthalic acid.


methyltetrahydrophthalic anhydride

A cyclic dicarboxylic anhydride that is the cyclic anhydride of methyltetrahydrophthalic acid.


hexahydrophthalic anhydride

A cyclic dicarboxylic anhydride that is the cyclic anhydride of hexahydrophthalic acid.


3-methylsuccinic anhydride

A tetrahydrofurandione that is succinic anhydride substituted by  a methyl group at position 3.


(5Z,9Z,12Z)-octadecatrienoyl group

A fatty-acyl group derived from (5Z,9Z,12Z)-octadecatrienoic acid.


N-methyl-N-pentylnitrosamine

A nitrosamine that has methyl and pentyl substituents. It is a potent oesophageal carcinogen.


A branched amino oligosaccharide comprising a linear trisaccharide of beta-D-mannose and two N-acetyl-beta-D-glucosamine residues all linked in sequence (1->4), to the mannosyl residue of which is (1->4)-linked an N-acetyl-beta-D-glucosaminyl residue, together with two N-acetyl-beta-D-glucosaminyl-(1->4)-[N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl tetrasaccharide units linked (1->3) and (1->6).


GALACTITOL

An optically inactive hexitol having meso-configuration.


caprolactams

A lactam in which the amide bond is contained within a seven-membered ring, which includes the amide nitrogen and the carbonyl carbon.


ciliatamide A

A lipopeptide that contains N-methylphenylalanine and lysine as the amino acid residues linked to a dec-9-enoyl moiety via an amide linkage (the R,R stereoisomer). It is isolated from the deep sea sponge Aaptos ciliata and exhibits antileishmanial activity.


CAPROLACTAM

A member of the class of caprolactams that is azepane substituted by an oxo group at position 2.


A member of the class of  caprolactams that is epsilon-caprolactam which carries an acetyl group at position 3.


ciliatamide B

A lipopeptide that contains N-methylphenylalanine and lysine as the amino acid residues linked to a octanoyl moiety via an amide linkage (the R,R stereoisomer). It is isolated from the deep sea sponge Aaptos ciliata and exhibits antileishmanial and moderate cytotoxicity towards HeLa cells.


A secondary carboxamide that is anthranilic acid in which the carboxy group has undergone condensation with the primary amino group of alpha-amino-epsilon-caprolactam, while the aryl-amino group has undergone condensation with the carboxy group of 1-benzothiophene-2-carboxylic acid. It is a selective, non-competitive antagonist of tropomyosin receptor kinase B (TrkB, also known as tyrosine receptor kinase B).


alsterpaullone

An organic heterotetracyclic compound that is 1,3-dihydro-2H-1-benzazepin-2-one which shares its 4-5 bond with the 3-2 bond of 5-nitro-1H-indole.


An  amino acid amide obtained by the intramolecular condensation of the terminal amino group with the carboxy group in lysine.


1-naphthaleneacetic acid

A naphthylacetic acid substituted by a carboxymethyl group at position 1.


GA5-Ag NP

Any coated Ag nanoparticle in which the the silver nanoparticles are encapsulated by 5 nm thick gum arabic.


gum arabic-coated Ag NP

Any coated Ag nanoparticle in which the the silver nanoparticles are encapsulated by gum arabic.


A galactotriose consisting of two alpha-D-galactopyranose and a D-galactopyranose residues joined in sequence by (1->3) gllycosidic bonds.


[3)-beta-D-Glcp6,NAc2-(1->] residue

A monosaccharide residue obtained formally by removal of the anomeric hydroxy group and the hydrogen attached to the 3-oxygen of Nacetyl-D-glucopyranose in which the 6-hydroxy group is acetylated. The 6-O-acetylated GlcpNAc epitope in various Shigella flexneri O-antigens.


monosaccharide residue

The divalent organic group that is one constituent monosaccharide unit of an oligo- or poly-saccharide, formed by loss the anomeric hydroxy group and of H from one of the remaining hydroxy groups.


[2)-alpha-L-Rhap3/4Ac-(1->] residue

A monosaccharide residue obtained formally by removal of the anomeric hydroxy group and the hydrogen attached to the 2-oxygen of L-rhamnopyranose in which either the 3- or 4-hydroxy group is acetylated.  The structure provided is representative of that found as the 3/4-O-acetylated Rha(III) epitope in Shigella flexneri strain 51251 and shows the acetylation at O-3, the more common site.


[4)-D-GlcpNS-(1->] residue

A monosaccharide residue obtained by removal of the anomeric hydroxy group and the hydrogen attached to the 4-hydroxy group of N-sulfo-D-glucosamine.


[4)-D-GlcpN-(1->] residue

A monosaccharide residue obtained by removal of the anomeric hydroxy group and the hydrogen attached to the 4-hydroxy group of D-glucosamine.


A 2-hydroxy-6-oxonona-2,4,7-trienedioic acid having (2E,4Z,7E)-configuration.


TRIACETYLCHITOTRIOSE

A linear amino trisaccharide consisting of three N-acetyl-beta-D-glucosamine residues linked (1->4).


An amino trisaccharide consisting of two 2-acetamido-2-deoxy-beta-D-glucopyranose residues and an alpha-D-galactopyranose residue joined in sequence by (1->6) glycosidic bonds.


A  monocarboxylic acid amide, being a derivative of (3,5-dioxopyrazolidin-4-yl)acetamide substituted at nitrogen by a 5-carboxypentyl chain.


mofebutazone

A pyrazolidine that is phenylbutazone lacking one of the phenyl substituents. It is used for treatment of joint and muscular pain.


kebuzone

A pyrazolidine that is phenylbutazone in which the two methylene hydrogens at postion 3 on the butyl chain are replaced by an oxo group.


The organoammonium salt formed from equimolar amounts of N(6)-(3,5-dioxo-1,2-diphenylpyrazolidin-4-ylacetyl)-6-aminohexanoic acid (Butaz) and hydrogen chloride.


oxyphenbutazone

A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome.


An ethyl ester resulting from the formal condensation of the carboxy group of 4-{4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl}benzoic acid with ethanol. It is an irreversible and cell-permeable inhibitor of ubiquitin-activating enzyme E1.


phenylbutazone

A member of the class of  pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.


A PYR-41 that has (E)-configuration.


A PYR-41 that has (Z)-configuration.


pyloric gastric gland goblet cell

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A goblet cell that is part of the epithelium of pyloric gland.


gastric goblet cell

description: A goblet cell that is part of the epithelium of stomach.


principal gastric gland goblet cell

description: A goblet cell that is part of the epithelium of principal gastric gland.


gastric cardiac gland goblet cell

description: A goblet cell that is part of the epithelium of gastric cardiac gland.


linalool 6-hydroperoxide

Linalool hydroperoxide where the hydroperoxy group is located at position 6 of the linalool skeleton; one of the two main allergenic hydroperoxides formed by autoxidation of linalool.


linalool hydroperoxide

Any peroxol formed by oxidation of the naturally occurring terpene linalool.


linalool 7-hydroperoxide

Linalool hydroperoxide where the hydroperoxy group is located at position 7 of the linalool skeleton; one of the two main allergenic hydroperoxides formed by autoxidation of linalool.


SCOPARONE

A member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities.


An amino disaccharide consisting of 2-acetamido-2-deoxy-alpha-D-galactopyranose and D-galactopyranose residues joined in sequence by a (1->6) glycosidic bond.


A branched amino oligosaccharide that is a dodecasaccharide derivative comprising a linear trisaccharide of beta-D-mannose and two N-acetyl-beta-D-glucosamine residues all linked in sequence (1->4), to the reducing-end N-acetyl-beta-D-glucosamine residue of which is linked (1->6) an alpha-L-fucosyl residue, while to the beta-D-mannose residue are linked two N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl tetrasaccharide units via (1->3) and (1->6) linkages.


Viomycin protonated to pH 7.3


cyclic peptide cation

A peptide cation in which the peptide is cyclic.


A cyclic peptide cation obtained by protonation of the two side-chain primary amino groups of pasireotide.


O-phosphoviomycin protonated to pH 7.3.


A cyclic peptide cation obtained by protonation of the arginine side-chains of peginesatide.


Conjugate base of ascr#36


poly(ethylene terephthalate) polymer

A polyester polymer, composed of poly(ethylene terephthalate) macromolecules.


heptacene

An acene that consists of seven ortho-fused benzene rings in a rectilinear arrangement.


acene

A polycyclic aromatic hydrocarbon consisting of fused benzene rings in a rectilinear arrangement.


nonacene

An acene that consists of nine ortho-fused benzene rings in a rectilinear arrangement.


BENZ(B)ANTHRACENE

An acene that consists of four ortho-fused benzene rings in a rectilinear arrangement.


ANTHRACENE

An ortho-fused tricyclic hydrocarbon comprising three fused benzene rings.


hexacene

An acene that consists of six ortho-fused benzene rings in a rectilinear arrangement.


An  organic heterotetracyclic compound that is 3,4-dihydro-2H,12H-pyrano[2,3-a]xanthen-12-one substituted by hydroxy groups at positions 5 and 9, a methoxy group at position 10, two methyl groups at position 2, a prenyl group at position 11 and an oxo group at position 12.


name: 1-[2-(3,4-dimethoxyphenyl)-1-oxoethyl]-4-piperidinecarboxylic acid methyl ester


PESCAPREIN XXI

A  resin glycoside that is  the pentasaccharide derivative of  jalapinolic acid. Isolated from the aerial parts of Ipomoea pes-caprae, it has been found to exhibit potential inhibitory effect against multidrug resistance in the human breast cancer cell line


alpha-C-GalCer

A neoglycosphingolipid that is a synthesized C-glycosyl analogue of myelin-derived galactosylceramide (Mye-GalCer).


name: Creatinine sulfate mixture with serotonin


An N-acetyl-beta-D-glycosaminyl glycopeptide consisting of an N-acetyl-beta-D-glycosaminyl-(1->4)-N-acetylmuramoyl moiety attached to the amino terminus of the dipeptide L-alanyl-D-isoglutamine.


A secondary alcohol that is nonane substituted by a hydroxy group at position 5.


A 4-hydroxy-D-proline in which the hydroxy group at position 4 has R-configuration.


A D-proline derivative that is D-proline monohydroxylated at position 3 (the cis-3-hydroxy-diastereomer).


The (3S)-trans-diastereomer of 3-hydroxy-L-proline.


hydroxyproline

A proline derivative that is proline substituted by at least one hydroxy group.


A L-proline derivative that is L-proline substituted by hydroxy groups at positions 3 and 4 (the 3S,4S diastereoisomer).


The L-enantiomer of  4-oxoproline.


A hydroxyproline that is L-proline substituted by a hydroxy group at position 2.


The (3R)-trans--diastereomer of 3-hydroxy-D-proline.


The D-stereoisomer of 4-hydroxyproline.


The L-stereoisomer of 3-hydroxyproline.


monohydroxyproline

A hydroxy-amino acid in which the amino acid specified is proline. A "closed" class.


dihydroxyproline

A hydroxyproline that is proline substituted by two hydroxy substituents.


pyroglutamic acid

An oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle.


oxoproline

A pyrrolidinemonocarboxylic acid consisting of proline bearing a single oxo substituent.


An  aminopyrrolidine that is D-proline substituted by a amino group at position 5 and a methyl group at position 3.


captopril

A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.


The 4-isomer of oxoproline.


The (3R)-cis-diastereomer of 3-hydroxy-L-proline.


name: 4,5-dioxo-1-(phenylmethyl)-3-pyrrolidinecarboxylic acid ethyl ester


A monohydroxyproline in which the hydroxy substituent is located at position C3.


An optically active form of 4-hydroxyproline having L-trans-configuration.


The L-stereoisomer of 4-hydroxyproline.


A 4-hydroxyproline substituted at N-1 by an ethoxycarbonyl group.


The D-enantiomer of 5-oxoproline.


L-Proline in which a hydrogen at the 4-position of the pyrrolidine ring is substituted by a hydroxy group (S-configuration).


PIDOLIC ACID

An optically active form of 5-oxoproline having L-configuration.


A 4-hydroxyproline substituted at N-1 by an methoxyacetyl group.


A N-acylpyrrolidine that is proline substituted by a propanoyl group at the nitrogen atom.


A lignan that consists of tetrahydrofuran substituted by a 3,4-dihydroxyphenyl group at position 2, a hydroxymethyl group at position 3 and a hydroxy(4-hydroxy-3-methoxyphenyl)methyl group at position 4. It has been isolated from Taxus yunnanensis.


progesterone 3-O-(carboxymethyl)oxime

An oxime O-ether consisting of progesterone having an O-(carboxymethyl)oxime group at the 3-position.


aztreonyl group

A univalent carboacyl group group formed from nucleophilic cleavage of the beta-lactam ring of aztreonam.


(R)-clenbuterol hydrochloride

The monohydrochoride salt of (R)-clenbuterol.


An amino disaccharide consisting of beta-D-galactose having an alpha-N-acetylneuraminyl residue attached at the 3-position


Ala-Ala zwitterion

A dipeptide zwitterion resulting from the transfer of a proton from the carboxy to the amino group of Ala-Ala; major species at pH 7.3.


name: cis-5,8,11-Eicosatrienoic acid methyl ester


An anthocyanidin glucoside having a 6-O-malonylglucosyl residue at the 3-position attached via a beta-linkage.


A purine 2',3'-dideoxyribonucleoside in which the nucleobase component is specified as adenine.


selenium-77 atom

A stable isotope of selenium with relative atomic mass 76.919915, 7.60 atom percent natural abundance and nuclear spin 1/2.


selenium-82 atom

A stable isotope of selenium with relative atomic mass 81.91670, 8.82 atom percent natural abundance and nuclear spin 0.


(+)-dihydroisorhamnetin

A dihydroisorhamnetin that has 2R,3R-configuration.


baclofen

An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of baclofen.


A sialodiosylceramide consisting of the tetrasaccharide alpha-N-glycoloylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose attached to the primary hydroxy function of a ceramide with undefined sphingoid base.


2-aminooctanoic acid zwitterion

An alpha-amino acid zwitterion that is 2-aminooctanoic acid in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3.


JASPAMIDE

A cyclodepsipeptide isolated from Jaspis splendens and has been shown to exhibit antineoplastic activity. It is an actin polymerization and stabilization inducer.


lactose 6'-phosphate

A lactose phosphate in which a single monophosphate substituent is placed at position 6 on the galactose ring of lactose.


leupeptin hemisulfate

A peptide sulfate salt obtained by combining leupeptin with 0.5 molar equivalents of sulfuric acid.


colistin B sulfate

The sulfuric acid salt of colistin B.


colistin A sulfate

The sulfuric acid salt of colistin A.


ACENAPHTHENE

A polycyclic aromatic hydrocarbon derived from naphthalene by the addition of an ethylene bridge connecting C-1 and C-8.


A  fluorobenzoyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 2-fluorobenzoic acid.


D-aspartate methyl ester residue

An amino-acid ester residue that is the methyl ester of a D-aspartate residue.


oxaprozin

A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is  non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthritis and rheumatoid arthritis.


The (25R)-diastereomer of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al.


An acyl-CoA thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 2-naphthoic acid..


colchicine

An  alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum.


(R)-colchicine

A colchicine that has (R)-configuration.


A glucosylceramide consisting of a beta-D-glucosyl residue attached to the primary hydroxyl group of N-acyl-(4E,6E)-hexadecasphingadienine.


A monocarboxylic acid amide obtained by formal condensation between N-butyl-3,3-dimethoxyalaninamide and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid.


An antiviral lignan isolated from Larrea tridentata, which consists of a 3,4-dimethyltetrahydrofuran skeleton substituted by a dihydroxybenzyl and hydroxyphenyl groups at position 2 and 5 respectively (the 2R,3S,4R,5R stereoisomer).


tensyuic acid F

A tensyuic acid that is itaconic acid which has been substituted at position 3 by a 3-(ethoxycarbonyl)propyl group. The (-)-isomer, isolated from Aspergillus niger FKI-2342.


An O-acyl carbohydrate that is beta-D-glucose bearing a 4-coumaroyl substituent at position 1.


haloindole

A compound based on an indole skeleton, containing one or more halogen atoms


curacomycin

A homodetic cyclic peptide found in several Streptomyces species, consisting of 3-hydroxyasparagine, L-ornithine, L-isoleucine, D-leucine, D-valine and 5-chloro-L-tryptophan joined in sequence in a cyclic arrangement by peptide linkages. It exhibits antibacterial properties.


fluoroindole

An organofluorine compound that is a compound based on an indole skeleton, containing one or more fluorine atoms.


spongotine A

A member of the class of imidazolines that is 4,5-dihydro-1H-imidazole which is substituted by a 1H-indole-3-carbonyl group at position 2 and a 6-bromo-1H-indol-3-yl group at position 4S. It is a bisindole alkaloid isolated from the marine sponge, Spongosorites sp.


A member of the class of indoles obtained by dimerisation of 2-imino-3-(7-chloroindol-3-yl)propanoic acid.


amisulbrom

A member of the class of bromoindoles that is 3-bromo-6-fluoro-2-methylindole substituted at position 1 by a 1-(dimethylsulfamyl)-1,2,4-triazole-3-sulfonyl group. A fungicide for use on potatoes to control late blight (Phytophthora infestans) and downy mildew [Plasmopara viticola). It has a low mammalian toxicity but it is considered to be a reproduction toxicant, is moderately toxic to birds and honey bees but poses a greater risk to aquatic species and earthworms.


bromoindole

An organobromine compound that is a compound based on an indole skeleton, containing one or more bromine atoms.


A fluoroindole that is 1H-indole substituted by a beta-D-glucopyranosyl, 4-cyclopropylbenzyl, and fluoro groups at positions 1, 3 and 4, respectively. It is a highly potent and selective SGLT2 inhibitor, with antihyperglycemic effects in high-fat diet-fed KK mice.


A 7-chlorotryptophan in which the chiral centre has D- (R-) configuration.


brivanib

A secondary alcohol resulting from the hydrolysis of the carboxylic ester group of brivanib alaninate. It is a dual VEGFR-2/FGFR-1 kinase inhibitor whose alanine prodrug, brivanib alaninate is currently under development as an oral agent for the treatment of cancer.


An organofluorine compound that is the 5-fluoro derivative of indole.


A non-proteinogenic alpha-amino acid that is tryptophan in which the hydrogen at position 5 on the indole ring is replaced by a bromo group.


N-bromoindole

A compound based on an indole skeleton with a bromine atom bonded to the nitrogen atom of the indole.


aetokthonotoxin

A bromoindole that is 2,3,5-tribromo-1H-indole which is substituted by a 5,7-dibromo-3-cyano-1H-indol-2-yl group at position 1. It is a biindole alkaloid isolated from the cyanobacterium Aetokthonos hydrillicola and causes vacuolar myelinopathy in bald eagles.


An L-tryptophan derivative having a chloro substituent at the 7-position.


dichlorochromopyrrolic acid

A pyrrole-2,5-dicarboxylic acid having 7-chloroindol-3-yl groups at the 3- and 4-positions.


indisulam

A chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development.


A bromoamino acid that is L-tryptophan in which the hydrogen at position 6 of the indole ring is substituted by bromine.


A tryptophan derivative having a chloro substituent at the 7-position of the indole ring.


brivanib alinate

A carboxylic ester resulting from the formal condensation of the carboxy group of L-alanine with the hydroxy group of brivanib. It is a prodrug of brivanib (BMS-540215), a potent oral dual inhibitor of VEGFR-2 and FGFR-1 (IC50 of 25 nM and 148 nM, respectively) and was in development for the treatment of hepatocellular and colon carcinomas.


indolauxipyr

A fluoroindole that is indole substituted by a 4-amino-6-carboxy-5-chloro-3-fluoropyridin-2-yl group at position 6 and by a fluoro group at position 7. It is a herbicide developed by Corteva Agriscience and sold as the corresponding ester, indolauxipyr-cyanomethyl.


A fluoroindole that is 6-fluoroindole in which the hydrogen at position 3 has been replaced by a 2-(pyridin-3-yl)vinyl group (trans configuration). It is a selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which directs the conversion of trypophan to kynurenin.


5-bromo-4-chloro-3-indolyl octanoate

A carboxylic ester obtained by formal condensation of the carboxy group of octanoic (caprylic) acid with the hydroxy group of 5-bromo-4-chloroindoxyl.


chloroindole

A compound based on an indole skeleton, containing one or more chlorine atoms


5-bromo-3-indolyl decanoate

An decanoate ester obtained by formal condensation of the carboxy group of decanoic acid with the hydroxy group of 5-bromoindoxyl.


indolauxipyr-cyanomethyl

A carboxylic ester resulting from the formal condensation of the carboxy group of indolauxipyr with hydroxyacetonitrile. It is a herbicide developed by Corteva Agriscience.


5-bromo-4-chloro-3-indolyl acetate

An acetate ester obtained by formal condensation of the carboxy group of acetic acid with the hydroxy group of 5-bromo-4-chloroindoxyl.


N-chloroindole

A chloroindole that is a compound based on an indole skeleton with a chlorine atom bonded to the nitrogen atom of the indole.


talmapimod

An indolecarboxamide obtained by formal condensation of the carboxy group of 6-chloro-3-[(dimethylamino)(oxo)acetyl]-1-methylindole-5-carboxylic acid with the secondary amino group  of (2S,5R)-1-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazine. It is a potent inhibitor of MAPK and exhibits anti-cancer properties.


BROMODEOXYTOPSENTIN

An aromatic ketone that is imidazole which is substituted by a 1H-indole-3-carbonyl group and a 6-bromo-1H-indol-3-yl group at  positions 2 and 4, respectively. Isolated from the Mediterranean shallow-water sponge, Topsentia genetrix. It is a potent inhibitor of MRSA pyruvate kinase and exhibits antibacterial properties.


A branched amino nonasaccharide derivative that is beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc in which the mannosyl group is substituted at position 6 by an alpha-L-Fuc-(1->6)-[beta-D-GalNAc-(1->4)]-beta-D-GlcNAc-(1->2)-alpha-D-Man group and at position 3 by a beta-D-GlcNAc-(1->2)-alpha-D-Man group.


A derivative of vindoline lacking the 11-O-methyl and 17-O-acetyl substituents.


name: 2-(4-fluorophenyl)-4-quinolinecarboxylic acid [2-oxo-2-(2-oxolanylmethylamino)ethyl] ester


A very long-chain primary fatty alcohol that is  heptacosan-1-ol substituted by a methyl group at position 26.


An amino tetrasaccharide comprising residues of galactose, N-acetylglucosamine, galactose and glucose in a linear sequence, all joined by beta-(1->3)-linkages.


poly(3,9-carbazole) polymer

A polycarbazole polymer, composed of poly(3,9-carbazole) macromolecules.


ISOXAZOLE

A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of  isoxazoles.


parecoxib

An N-acylsulfonamide resulting from the formal condensation of valdecoxib with propionic acid. It is a prodrug for valdecoxib.


MUSCIMOL

A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.


A 3-[({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid that is the (R)-enantiomer of KI16425.


A tripeptide resulting from the formal condensation of the carboxy group of N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valine with the amino group of benzyl (2E,4S)-4-(L-leucylamino)-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate. It is an inhibitor of the main protease of SARS-CoV-2.


HYMEXAZOL

A member of the class of isoxazoles carrying hydroxy and methyl substituents at positions 3 and 5 respectively. It is used worldwide as a systemic soil and seed fungicide for the control of diseases caused by Fusarium, Aphanomyces, Pythium, and Corticium spp. in rice, sugarbeet, fodderbeet, vegetables, cucurbits, and ornamentals.


An isoxazole that is 3-isoxazoline substituted at position 5 by an oxo group.


dafadine D

An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(3-trifluoromethylphenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine.


acivicin

An L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl group. A glutamine analogue antimetabolite, it interferes with glutamate metabolism and  several glutamate-dependent synthetic enzymes. It is obtained as a fermentation product of Streptomyces sviceus bacteria.


A non-proteinogenic L-alpha-amino acid that is L-alanine in which one of the methyl hydrogens is replaced by a 5-oxoisoxazolin-2-yl group.


TOPRAMEZONE

An aromatic ketone that is phenyl 1H-pyrazol-4-yl ketone in which the pyrazolyl group is substituted at positions 1 and 5 by methyl and hydroxy groups, respectively, and in which the phenyl group is substituted at positions 2, 3, and 4 by methyl, 4,5-dihydro-1,2-oxazol-3-yl, and methylsulfonyl groups, respectively. A potent inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD) that is rapily metabolised by corn to non-active substances, it is used as a herbicide for the treatment of broadleaf weeds.


An isoxazole compound having a methyl substituent at the 3-position and a 5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl substituent at the 5-position.


A member of the class of isoxazoles that is the carbamate ester obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)ethyl hydrogen carbonate with the amino group of 3-({[4-(4-amino-3-methyl-1,2-oxazol-5-yl)phenyl]methyl}sulfanyl)propanoic acid.


ISOXAFLUTOLE

A member of the class of isoxazoles that is 1,2-oxazole substituted by a 2-(methanesulfonyl)-4-(trifluoromethyl)benzoyl group and a cyclopropyl group at positions 4 and 5, respectively. It is a 4-hydroxyphenylpyruvate dioxygenase inhibitor which is used as a herbicide for weed control in maize and sugarcane.


sulfamethoxazole hydroxylamine

A sulfonamide compound having a 4-hydroxylaminophenyl group attached to the sulfur atom and a 1,2-oxazol-3-yl group attached to the nitrogen atom.


dafadine O

An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(3-methoxyphenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine.


dafadine C

An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(2,6-difluorophenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine.


luminespib

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(2,4-dihydroxy-5-isopropylphenyl)-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxylic acid with the amino group of ethylamine.


5-methyl-3-isoxazolyl sulfate

A heterocyclyl sulfate that is 1,2-oxazol-3-yl hydrogen sulfate substituted by a methyl group at position 5.


A member of the class of isoxazoles that is L-alanine in which one of the methyl hydrogens is replaced by a 5-oxoisoxazolin-4-yl group.


sparsentan

A biphenyl that is 1,1'-biphenyl substituted by (4,5-dimethyl-1,2-oxazol-3-yl)aminosulfonyl, ethoxymethyl, and (2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl groups at positions 2, 2' and 4', respectively. It is a dual antagonist of endothelin and angiotensin II receptors approved for the reduction of proteinuria in adults with primary immunoglobulin A nephropathy at risk of rapid disease progression.


dafadine A

An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(2,6-dimethylphenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine.


A member of the class of isoxazoles carrying phenyl, 2-aminopyrimidin-4-yl and methyl substituents at positions 3, 4 and 5 respectively.


A member of the class of phenylureas that is urea in which one of the nitrogens has been substituted by a 5-tert-butyl-1,2-oxazol-3-yl group, while the other has been substituted by a 3-fluoro-4-hydroxyphenyl group, the hydroxy group has been converted to the corresponding 1H-pyrazolo[3,4-d]pyrimidin-4-yl ether. It is an FLT3 (fms-like tyrosine kinase 3)and Wnt/beta-catenin signaling inhibitor.


sulfisoxazole

A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.


dafadine B

An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(2-chloro-4-fluorophenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine


isoxicam

A monocarboxylic acid amide that is piroxicam in which the pyrid-2-yl group is replaced by a 5-methyl-1,2-oxazol-3-yl group. A non-steroidal anti-inflammatory drug, it was withdrawn from the market in the 1980s following its association with cases of Stevens-Johnson syndrome.


N-acetylsulfamethoxazole

A sulfonamide compound having a 4-acetamidophenyl group attached to the sulfur atom and a 1,2-oxazol-3-yl group attached to the nitrogen atom.


praliciguat

A member of the class of pyrazoles that is 5-fluoro-2-(1H-pyrazol-3-yl)pyrimidine which is substituted by a 2-fluorobenzyl group at position 1, 1,2-oxazol-3-yl group at position 5, and by a [3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]nitrilo group at position 4. It is a soluble guanylate cyclase stimulator under clinical development for the treatment of heart failure with preserved ejection fraction.


(S)-ATPA

A non-proteinogenic L-alpha-amino acid that is L-alanine in which one of the methyl hydrogens is replaced by a 5-tert-butyl-3-hydroxy-isooxazol-4-yl group.


nitrososulfamethoxazole

A sulfonamide compound having a 4-nitrosophenyl group attached to the sulfur atom and a 1,2-oxazol-3-yl group attached to the nitrogen atom.


leflunomide

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.


A 3-[({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid that is the (S)-enantiomer of KI16425.


lotilaner

A member of the class of isoxazoles that is 4,5-dihydro-1,2-oxazole substituted by 4-methyl-5-({2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl}carbamoyl)thiophen-2-yl, trifluoromethyl, and 3,4,5-trichlorophenyl groups at positions 3, 5 and 5, respectively (the 5S-stereoisomer). It is a gamma-aminobutyric acid (GABA)-gated chloride channel inhibitor selective for mites, approved for the treatment of Demodex blepharitis.


Ser-Asp-Lys

A tripeptide composed of L-serine, L-aspartic acid and L-lysine amino acids joined in sequence by peptide linkages.


intestinal brush border layer

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A brush border layer that is part of a intestine.


peptide aptamer

An aptamer that is an artificial protein selected or engineered to bind a specific target molecule.


methyl propenyl ketone

An enone that is pent-2-ene in which the two methylene hydrogens have been replaced by an oxo group.


A methyl propenyl ketone in which the double bond has (E)-configuration. It is a key odorant responsible for the chestnut-like aroma in green tea.


magnesium dichloride monohydrate

A hydrate that is the monohydrate form of magnesium dichloride.


chlorophyll

A family of magnesium porphyrins, defined by the presence of a fifth ring beyond the four pyrrole-like rings. The rings can have various side chains which usually include a long phytol chain.


3-vinylbacteriochlorophyllide a

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 3-vinylbacteriochlorophyll a.


protochlorophyllide

An analogue of chlorophyll that lacks the phytol side-chain. The parent of the protochlorophyllide class.


A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 12-ethyl-8-propyl-3-vinylbacteriochlorophyll d.


bacteriochlorophyllide c

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of any bacteriochlorophyll c.


name: magnesium 13(1)-hydroxyprotoporphyrin 13-monomethyl ester


name: magnesium protoporphyrin 13-monomethyl ester


CaMn4O5 cluster

A  metal-oxygen cluster containing 1 calcium atom, 4 managanese atoms and 5 oxygen atoms. It is the catalytic center of water oxidation in photosystem II (PSII).


bacteriochlorophyllide a

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of bacteriochlorophyll a.


A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of any 7(1),7(1)-dihydroxybacteriochlorophyll d.


bacteriochlorophyll

Chlorophylls of photosynthetic bacteria.


chlorophyllide

Chlorophylls lacking the terpenoid side chain such as phytyl or farnesyl.


bacteriochlorophyllide g

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of bacteriochlorophyll g.


7,7-dihydroxybacteriochlorophyllide c

A chlorophyllide in which two of the methyl hydrogens at position 7 of any bacteriochlorophyllide c have been replaced by hydroxy groups.


magnesium protoporphyrin(2-)

The conjugate base of magnesium protoporphyrin, formed by deprotonation of the carboxyethyl groups at C-13 and C-17. It is the principal species at pH 7.3.


magnesium chloride

A magnesium salt comprising of two chlorine atoms bound to a magnesium atom.


bacteriochlorophyllide e

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of any bacteriochlorophyll e.


3-vinylbacteriochlorophyllide d

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 3-vinylbacteriochlorophyll d.


A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyll d.


2,4-divinyl protochlorophyllide a

A protochlorophyllide compound having vinyl substituents at the 2- and 4-positions.


chlorophyll a'

Chlorophyll a' is the C13(2)-epimer of chlorophyll a.


7(1)-hydroxybacteriochlorophyllide d

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of any 7(1)-hydroxybacteriochlorophyll d.


bacteriochlorophyll c

A chlorophyll of photosynthetic bacteria, for example green sulfur bacteria.


bacteriochlorophyllide f

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of any bacteriochlorophyll f.


A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 3-(1-hydroxyethyl)bacteriochlorophyll a.


geranylgeranyl bacteriochlorophyllide a

A chlorophyll that is the ester obtained by formal condensation between the carboxy group of bacteriochlorophyllide a and the hydroxy group of geranylgeraniol.


divinyl chlorophyll a

A carboxylic ester obtained by formal condensation of the carboxy group of divinyl chlorophyll a with the hydroxy group of (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol.


A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 8,12-diethyl-3-vinylbacteriochlorophyll d.


divinyl chlorophyll b

A carboxylic ester obtained by formal condensation of the carboxy group of divinyl chlorophyll b with the hydroxy group of (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol.


7(1)-hydroxychlorophyll a

A member of the class of chlorophyll that is chlorophyll a substituted at position 7(1) by a hydroxy group.


name: magnesium 13(1)-oxoprotoporphyrin 13-monomethyl ester


3-(1-hydroxyethyl)chlorophyllide a

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 3-(1-hydroxyethyl)chlorophyll a.


3-acetylchlorophyllide a

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 3-acetylchlorophyll a.


geranylgeranyl-chlorophyll a

A chlorophyll that is the ester obtained by formal condensation between the carboxy group of chlorophyllide a and the hydroxy group of geranylgeraniol.


magnesium dichloride dihydrate

A hydrate that is the dihydrate form of magnesium dichloride.


bacteriochlorophyllide d

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of any bacteriochlorophyll d.


UDP-beta-L-rhamnose

A UDP-L-rhamnose in which the rhamnose portion has beta-configuration at its anomeric centre


UDP-rhamnose

A UDP-sugar in which the sugar component is rhamnose.


UDP-L-rhamnose

A UDP-rhamnose in which the rhamnose component has L-configuration.


flumorph

A mixture comprising approximately equal amounts of (E)- and (Z)-fluomorph. It is used as an agrochemical fungicide for the control oomcyetes such as downey mildew on vegetables and grapes.


morpholine antifungal agent

A member of the class of morpholines that has significant antifungal properties.


aldimorph

A mixture of containing 65-75% 4-alkyl-2,6-dimethylmorpholines and 35-25% 4-alkyl-2,5-dimethylmorpholines, where more than 85% of the total has dodecyl as the alkyl group, and where 'alkyl' may also be octyl, decyl, tetradecyl or hexadecyl, and where the cis:trans ratio is 1:1. Formerly used as a fungicide for the control of powdery mildew in cereal crops, it is no longer approved for use within the European Union.


(Z)-dimethomorph

An enamide resulting from the formal condensation of (2Z)-3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acrylic acid with the amino group of morpholine. The agricultural fungicide dimethomorph is a mixture of (E)- and (Z)-dimethomorph; only the Z isomer has fungicidal activity.


tridemorph

A mixture of 4-alkyl-2,6-dimethylmorpholines, where 'alkyl' is a mixture of C11 to C14 homologues of which 60-70% is tridecyl. A systemic fungicide, it is no longer approved for use within the European Union.


morpholine fungicide

Any morpholine antifungal agent used as a fungicide.


amorolfine hydrochloride

A hydrochloride resulting from the formal reacton of equimolar amounts of hydrogen chloride and amorolfine. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used for the topical treatment of fungal nail and skin infections.


amorolfine

A member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections.


dodemorph

A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a cyclododecyl group. It is a fungicide used for the control of powdery mildew, particularly in rose culture.


DIMETHOMORPH

A mixture of (E)- and (Z)-dimethomorph in an unspecified ratio. It is used as a systemic fungicide used on vines, potatoes, and greenhouse crops; only the Z isomer has fungicidal activity.


morpholine antifungal drug

Any morpholine antifungal agent used to treat fungal infections in humans or animals.


hormone

Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.


acceptor

A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity.


donor

A molecular entity that can transfer ("donate") an electron, a pair of electrons, an atom or a group to another molecular entity.


nutrient

A nutrient is a food component that an organism uses to survive and grow.


GlyTouCan G84452RH

A partially-defined glycan consisting of five hexosyl groups, four acetaminohexosyl groups, a 6-deoxyhexosyl group and an N-acetcylneuraminic acid group (identities and connectivity unknown). Composition: Hex5 HexNAc4 6dHex1 Neu5Ac1.


N-acetyl-beta-neuraminic acid

N-Acetylneuraminic acid with beta configuration at the anomeric centre.


thiomarinol B

A sulfone produced by a marine bacterium Alteromonas rava and has been shown to exhibit antibacterial activity against Gram-positive and Gram-negative bacteria.


name: kidney loop of Henle thin descending limb epithelial cell

description: An epithelial cell that is part of some loop of Henle thin descending limb.


name: kidney loop of Henle long descending thin limb inner medulla epithelial cell

description: Epithelial cell of the descending thin limb of the long loop (juxtamedullary) nephron that spans the inner medulla. It is known in some mammalian species that the long descending limb of the loop of Henle in the inner medulla selectively expresses the nuclear receptor Nr2e3, the Ig kappa chain Igkc, and the secreted protein dermokine (Dmkn). SLC14A2, which expresses a urea transporter, is also expressed in the inner medulla.


name: kidney loop of Henle long descending thin limb outer medulla epithelial cell

description: Epithelial cell of the descending thin limb of the long loop (juxtamedullary) nephron that spans the outer medulla (inner stripe). It is known in some mammalian species that the long descending limb of the loop of Henle in the outer medulla selectively expresses the secreted activin-antagonist protein follistatin (Fst), the GPI-linked adhesion protein Cdh13, and the protein kinase Stk32a.


name: kidney loop of Henle short descending thin limb epithelial cell

description: Epithelial cell of the descending thin limb of the short loop (cortical) nephron limited to the outer medulla (mainly inner strip). It is known in some mammalian species that the short descending limb of the loop of Henle selectively expresses the serine protease Corin, the homeobox TF Uncx, and the urea channel Slc14a2.


A sulfur-containing carboxylic acid consisting of isobutyric acid having mercapto substituents on both beta-carbons.


dimercaprol

A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.


The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.


A dithiol that is propane substituted by thiol groups at positions 1 ans 3.


unithiol

An alkanesulfonic acid that is propane-1-sulfonic acid substituted by sulfanyl groups at positions 2 and 3.


succimer

A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.


glucosyl-(heptosyl)2-(KDO)2-lipid A

A lipid A derivative having an alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo moiety attached to the free primary hydroxy group of lipid A.


A galactoglycerolipid that consists of 1,2-diacyl-sn-glycerol having (7Z,10Z)-hexadecadienoyl and linoleoyl as the acyl groups and a 6-O-(alpha-D-galactopyranosyl)-beta-D-galactopyranosyl residue attached at position 3. It has been found in Daphnia pulex and exhibits cytotoxic activity.


A nitroalkane that is propane substituted at C-1 by a nitro group.


3,5-dinitro-4-hydroxyphenylpyruvic acid

A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a 3,5-dinitro-4-hydroxyphenyl group.


A 6-methoxy-3-methyl-2-all-trans-polyprenylhydroquinone in which the polyprenyl component is specified as all-trans-nonaprenyl.


A secondary alcohol that is tridecane substituted by a hydroxy group at position 2.


A fatty amide comprising nonadecanamide having tetradecyl, oxo and amino substituents at the 2-, 4- and 5-positions respectively.


A ceramide 1-phosphate that is the N-docosanoyl derivative of sphingosine.


L-alpha-phenylglycine

The S stereoisomer of alpha-phenylglycine.


quercetin 5,7,3',4'-tetramethyl ether

A tetramethoxyflavone that is  the 5,7,3',4'-tetramethy-derivative of quercetin.


hydrogentellurite

A monovalent inorganic anion obtained by removal of a proton from H2TeO3


CHLORPYRIFOS

An  organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.


A 2-methoxy-6-all-trans-polyprenylhydroquinone in which the polyprenyl component is specified as all-trans-nonaprenyl.


A polyprenylhydroquinone in which the polyprenyl substituent is at C-2 with an additional methoxy group present at C-6.


A polyprenylhydroquinone in which the polyprenyl substituent is hexaprenyl at C-2; an additional methoxy group is also present at C-6.


A 2-methoxy-6-all-trans-polyprenylhydroquinone in which the polyprenyl component is specified as all-trans-heptaprenyl.


An alkapentaene that is henicos-1-ene with 4 cis double bonds at positions 6,9,12 and 15.


poly(N-acryloxysuccinimide) polymer

An acryilic polymer, composed of poly(N-acryloxysuccinimide) macromolecules.


A glycosylglycerol derivative that is 2-O-alpha-D-glucopyranosyl-beta-D-galactofuranose in which the anomeric hydroxy group has been converted into its 2,3-dihydroxypropyl glycoside.


A glycosyloxy group comprising an alpha-D-mannosyloxy residue, to which are linked (1->4) a beta-D-galactose residue and (1->2) an alpha-D-mannosyl-(1->2)-alpha-D-mannosyl disaccharide unit. A Leishmania lipophosphoglycan capping tetrasaccharide unit.


A C-glycosyl compound that is luteolin substituted at positions 6 and 8 by alpha-L-arabinopyranosyl and beta-D-glucosyl residues respectively.


An amino-acid residue that is formed when the carboxy group of any amino acid (where R is the side chain) undergoes a cyclodehydration reaction with a neighbouring L-serine amino acid in a protein, resulting in the formation of a 2-oxazoline ring which is dehydrogenated to the corresponding 1,3-oxazole moiety.


The dihydrate of a tris(1,10-phenanthroline)ruthenium(2+) dichloride salt.


peramivir hydrate

A hydrate that is the trihydrate form of peramivir. Used for the treatment of acute uncomplicated influenza in patients 18 years and older who have been symptomatic for no more than two days.


A CDP-3,6-dideoxy-D-mannose in which the anomeric centre of the sugar component has alpha-configuration.


A CDP-sugar in which the sugar component is 3,6-dideoxy-D-mannose.


A ceramide that is the N-docosanoyl derivative of 4-hydroxyeicosasphinganine.


nickel chloride hexahydrate

A hydrate of nickel chloride containing nickel (in the +2 oxidation state), chloride and water moeities in the ratio 1:2:6.


An amino-acid cation residue obtained by protonation of the amino group of (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl residue; major species at pH 7.3.


name: 2-[[cyclohexyl(oxo)methyl]amino]-1,3-benzothiazole-6-carboxylic acid methyl ester


L-methionine 2-naphthylamide

An L-methionine derivative that is the amide obtained by formal condensation of the carboxy group of L-methionine with the amino group of 2-naphthylamine.


A methionine derivative that is the amide obtained by formal condensation of the carboxy group of methionine with the amino group of 2-naphthylamine.


D-methionine 2-naphthylamide

A D-methionine derivative that is the amide obtained by formal condensation of the carboxy group of D-methionine with the amino group of 2-naphthylamine.


Major species at pH 7.3.


axon cytoplasm

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any cytoplasm that is part of a axon.


A glycol that is cumene carrying two hydroxy substituents at positions 1 and 2


An amino disaccharide consisting of a beta-D-galactopyranose residue and two 2-acetamido-2-deoxy-beta-D-glucopyranose residues joined in sequence by (1->4) glycosidic bonds.


The stable isotope of beryllium with relative atomic mass 9.012182, 100 atom percent natural abundance and nuclear spin 3/2.


beryllium atom

Alkaline earth metal atom with atomic number 4.


(24S)-24-hydroxycholesterol 3-hexanoate

A sterol ester that is the 3-hexanoyl derivative of (24S)-24-hydroxycholesterol.


hexanoate ester

Any fatty acid ester where the carboxylic acid component is hexanoic (also known as caproic) acid.


methyl hexanoate

A fatty acid methyl ester derived from hexanoic (caproic acid).


ethyl hexanoate

A fatty acid ethyl ester obtained by the formal condensation of hexanoic acid with ethanol.


A cholesteryl 6-O-acyl-beta-D-galactoside having hexanoyl as the 6-O-acyl group.


butyl hexanoate

A hexanoate ester obtained by the formal condensation of the carboxy group of hexanoic acid (caproic acid) with butan-1-ol. It is a volatile compound found in apples and peaches.


taiwanschirin D

An  organic heterotetracyclic compound isolated from the stems of Kadsura matsudai.


hydrocortisone caproate

The 21-O-hexanoyl derivative of hydrocortisone.


propyl hexanoate

A hexanoate ester obtained by the formal condensation of the carboxy group of hexanoic acid (caproic acid) with  propan-1-ol.


PESCAPREIN XXIX

A resin glycoside that is the pentasaccharide derivative of jalapinolic acid. Isolated from the aerial parts of Ipomoea pes-caprae, it has been found to exhibit potential inhibitory effect against multidrug resistance in the human breast cancer cell line.


isobutyl hexanoate

A hexanoate ester resulting from the formal condensation of hexanoic acid (caproic acid) with isobutanol.


hexyl hexanoate

A hexanoate ester obtained by the formal condensation of the carboxy group of hexanoic acid (caproic acid) with hexan-1-ol. It is a constituent found in passion fruit, apples, strawberries and wine.


3-methylbutyl hexanoate

A fatty acid ester obtained by the formal condensation of the carboxy group of hexanoic acid (caproic acid) with the alcoholic hydroxy group of 3-methylbutan-1-ol (isoamylol).


ROHITUKINE

A member of the class of chromones that is 4H-chromen-4-one in which the hydrogens at positions 2,5,7 and 8 are replaced by methyl, hydroxy, hydroxy, and (3S,4R)-3-hydroxy-1-methylpiperidin-4-yl groups, respectively. It is an alkaloid initially isolated from Amoora rohituka and is a precursor of the anti-cancer compound flavopiridol.


(14R)-14-hydroxypentadecanoic acid

An (omega-1)-hydroxy fatty acid that is pentadecanoic acid in which the 14-pro-R hydrogen is replaced by a hydroxy group.


adamanzane

Any one of a class of organic heteropolycyclic compounds having a polycyclic cage structure containing four nitrogen atoms linked by carbons, the nitrogens occupying the vertices of a tetrahedron or similar cyclic structure, with potentially four faces and six edges, with carbon chains running approximately along the edges.


penimepicycline

A penicillinate salt obtained by combining equimolar amounts of  phenoxymethylpenicillin and pipacycline.


A 2-(3,4-dihydroxyphenyl)-2,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one that has (R) configuration.


A glycodiosylceramide consisting of a beta-D-galactosyl-(1->4)-beta-D-glucosyl moiety attached to the primary hydroxyl group of N-acylated C20 sphingosine.


OXAZOLE

A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.


name: N,N-diethylcarbamodithioic acid [2-(2-methyl-1H-indol-3-yl)-2-oxoethyl] ester


A member of the class of phenols that phenol substituted by methyl groups at positions 2 and 5.


malaoxon

A racemate comprising equimolar amounts of (R) and (S)-malaoxon. It is the active insecticide of the proinsecticide malathion.


L-seriniumyl group

The organic cationic group formed from L-serinium; the major structure at pH 7.3 of the L-seryl group, formed by protonation of the alpha-amino group.


A methyl-branched fatty acyl-CoA in which the unspecified acyl group carries a methyl substituent at position 2.


A (2S)-2-methylacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (2S)-2-methylpentadecanoic acid.


A (2S)-2-methylacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (2S)-2-methylbutanoic acid.


A (2R)-2-methylacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (2R)-2-methyltetradecanoic acid.


A (2S)-2-methylacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (2S)-2-methyltetradecanoic acid.


A cysteine derivative in which the thiol hydrogen of cysteine is replaced by a 5-acetamido-2-hydroxyphenyl group.


GUTHION

A member of the class of  benzotriazines that is  1,2,3-benzotriazine substituted by an oxo group at position 4 and a [(dimethoxyphosphorothioyl)sulfanyl]methyl group at position 3.


name: phosphatidylserine amidated glycine residue(2-)


name: C-terminal amino acid- phosphatidylserine amidated glycine residue(2-)


4-O-dimethylallyl-L-tyrosine zwitterion

An amino acid zwitterion obtained by transfer of a proton from the amino to the carboxy group of 4-O-dimethylallyl-L-tyrosine; major species at pH 7.3.


dihydroconiferyl alcohol

A member of class of phenols that is 2-methoxyphenol substituted by a 3-hydroxypropyl group at position 4.


name: (2S)-2-[[[4-[(3-methylanilino)-oxomethyl]-1H-imidazol-5-yl]-oxomethyl]amino]-3-phenylpropanoic acid (phenylmethyl) ester


ATTO 565 para-isomer(1+)

The para-isomer of ATTO 565 cation.


A mimotope of the pyruvate dehydrogenase E2 component (PDC-E2) comprising a [(2E)-3-(4-chlorophenyl)prop-2-enoyl]-group linked to the lipoated PDC-E2 core dodecapeptide (DKATIGFEVQEE) at N-6 of lysine.


vincristine

A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.


naphthalenetetrol

A hydroxynaphthalene carrying four hydroxy substituents.


A naphthalenetetrol that is naphthalene substituted by hydroxy groups at positions 1, 3, 6 and 8.


A naphthalenetetrol that is naphthalene which is substituted by hydroxy groups at postions 1, 2, 4, and 8. Also known as naphthalene-1,3,4,5-tetrol.


A steroid glucosiduronic acid that is chenodeoxycholic acid  having a single beta-D-glucuronic acid residue attached at position 3.


A hydrochloride salt resulting from the reaction of (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane with 2 mol eq. of hydrogen chloride. An ATP-competitive inhibitor of Rho kinase (ROCK).


EMERICELLAMIDE A

An emericellamide derived from N-[(2R,3R,4S)-3-hydroxy-2,4-dimethyldecanoyl]glycyl-L-valyl-L-leucyl-L-alanyl-L-alanine by the formal intramolecular condensation of the alcoholic hydroxy group with the C-terminal carboxylic acid group.


name: 4-chloro-3-[[2-(4-methyl-1-piperidinyl)-1-oxoethyl]amino]benzoic acid methyl ester


A fructan derivative consisting of (2->6)-beta-D-fructan attached to an alpha-D-glucopyranosyl residue via a (1<->1) linkage.


fructan derivative

A homopolysaccharide derivative which is formally derived from a fructan.


The 9H-tautomer of purine.


pracinostat

A hydroxamic acid that is N-hydroxyacrylamide which is substituted at position 3 by a 2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl group (the E isomer). An orally available pan-histone deacetylase inhibitor with demonstrated activity in the treatment of advanced solid tumours.


benzimidazole

A mancude organic heterobicyclic parent that is a heterocyclic organic compound comprising fused benzene and imidazole rings.


A benzothiophene in which the benzene ring is fused to the thiophene ring across positions 3 and 4.


indole

Either of two isomeric forms comprising a benzene ring fused to a pyrrole ring.


BENZIMIDAZOLE

The 1H-tautomer of benzimidazole.


The 3H-tautomer of purine.


A simplest member of the class of chromene in which the heterocyclic pyran ring has a double bond between positions 2 and 3.


The 1H-tautomer of purine.


The 7H-tautomer of purine.


isochromenylium

An organic cation that is isochromene with a protonated oxygen.


purine

A heterobicyclic aromatic organic compound comprising a pyrimidine ring fused to an imidazole ring; the parent compound of the purines.


BENZO[D]OXAZOLE

A benzoxazole in which the benzene ring is fused to a 1,3-oxazole ring across positions 4 and 5.


A simplest member of the class of chromene in which the heterocyclic pyran ring has a double bond between positions 3 and 4.


BENZO[C]ISOXAZOLE

A benzoxazole in which the benzene ring is fused to a 1,2-oxazole ring across positions 3 and 4.


name: 5-methoxy-3-methyl-2-benzofurancarboxylic acid (3-cyano-4-imino-2-oxopentyl) ester


A long-chain primary fatty alcohol that is  nonadecan-1-ol substituted by a methyl group at position 18.


long-chain primary fatty alcohol

A long-chain fatty alcohol in which the hydroxy group is attached to a methylene (CH2) group.


A long-chain primary fatty alcohol that is  henicosan-1-ol substituted by a methyl group at position 20.


A long-chain primary fatty alcohol that is tridecan-1-ol substituted a methyl group at position 12.


ISOSTEARYL ALCOHOL

A long-chain primary fatty alcohol that is heptadecan-1-ol substituted by a hydroxy group at position 1 and a methyl group at position 16.


A long-chain primary fatty alcohol that is octadecan-1-ol (stearyl alcohol) substituted by a methyl group at position 16.


A long-chain fatty alcohol that is stearyl alcohol which has been dehydrogenated to introduce a cis double bond between positions 13 and 14.


A long chain fatty primary alcohol that is octadecanol containing three double bonds located at positions 9, 12 and 15.


A long-chain primary fatty alcohol that is henicosane in which a hydrogen attached to one of the terminal carbons is replaced by a hydroxy group. It has been isolated from the aerial parts of Siegesbeckia orientalis and from an Italian bread wheat variety, Pegaso, and its 11 near-isogenic lines.


A long-chain primary fatty alcohol that is tridecane substituted by a hydroxy group at position 1.


A long-chain fatty alcohol that is dodecan-1-ol bearing a methyl substituent at position 11.


A long-chain primary fatty alcohol that is hexadecan-1-ol substituted by a methyl group at position 14.


MYRISTYL ALCOHOL

A long-chain fatty alcohol that is tetradecane substituted by a hydroxy group at position 1.


A long-chain fatty alcohol that is hexadecan-1-ol bearing a methyl substituent at position 15.


A long-chain primary fatty alcohol that is icosan-1-ol substituted by a methyl group at position 18.


A long-chain fatty alcohol that is (13Z)-docosene in which one of the terminal methyl hydrogens at position 1 is replaced by a hydroxy group


A long-chain primary fatty alcohol that is docosan-1-ol substituted by a methyl group at position 20.


A long-chain primary fatty alcohol that is nonadecane in which one of the terminal methyl hydrogens is replaced by a hydroxy group.


A long-chain primary fatty alcohol that is  pentadecan-1-ol substituted by a methyl group at position 14.


A long-chain primary fatty alcohol that is (5Z,8Z,11Z,14Z)-icosatetraene in which one of the methyl hydrogens at position 1 is replaced by a hydroxy group.


isopersin

A long-chain primary fatty alcohol that is henicosan-1-ol which carries an acetoxy group at position 2, keto group at position 4, and two double bonds at positions 12 and 15.


OLEYL ALCOHOL

A long chain fatty alcohol that is octadecanol containing a double bond located at position 9 (the Z-geoisomer).


CETOSTEARYL ALCOHOL

A long-chain primary fatty alcohol consisting of a hydroxy function at C-1 of an unbranched saturated chain of 18 carbon atoms.


2-hydroxyethyl octadecanoate

An octadecanoate ester obtained by formal condensation between the carboxy group of octadecanoic (stearic) acid and one of the hydroxy groups of ethylene glycol. It is an ingredient in many personal care products and cosmetics.


A long chain fatty alcohol that is octadecanol containing two double bonds located at positions 9 and 12 (the 9Z,12Z-geoisomer).


A diol that is hexadecane substituted by hydroxy groups at positions 1 and 16.


A long-chain primary fatty alcohol that is (8Z,11Z,14Z)-icosatriene in which one of the methyl hydrogens at position 1 is replaced by a hydroxy group.


(R)-methcathinone

A 2-methylamino-1-phenylpropan-1-one that has (R)-configuration.


A 3-hydroxybutane-1,2,3-tricarboxylic acid which has (2S,3R) configuration.


methylisocitric acid

A tricarboxylic acid that is isocitric acid substituted by a methyl group alpha- to one of the carboxylic acid groups.


A tricarboxylic acid that is butan-2-ol in which a hydrogen from each of positions 2, 3, and 4 has been replaced by carboxy groups.


An O-(S-acylpantetheine-4'-phosphoryl)-L-serine residue in which the S-acyl group is specified as octanoyl.


A 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine zwitterion in which the phosphatidyl acyl groups are both specified as oleoyl (9Z-octadecenoyl); major species at pH 7.3.


topiramate

A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine.


nucleocidin

A nucleoside antibiotic that is 5'-O-sulfamoyladenosine in which the hydrogen atom at position 4' is replaced by a fluorine atom. It is a natural product synthesized by several Streptomyces species. It exhibits broad spectrum antibacterial activity, and also has a strong effect against Trypanosoma brucei, the protozoan parasite responsible for the African sleeping sickness.


acesulfame

A sulfamate ester that is 1,2,3-oxathiazin-4(3H)-one 2,2-dioxide substituted by a methyl group at position 6.


A trichlorobenzene with chloro substituents at positions 1, 2 and 4.


name: N-[(3-nitrophenyl)methylideneamino]carbamic acid tert-butyl ester


A polyanionic polymer obtained by deprotonation of the carboxy groups of [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl]n; major species at pH 7.3.


An amino pentasaccharide that is beta-D-Galp-(1->3)-[beta-D-Galp-(1->4)-beta-D-GlcpNAc-(1->6)]-D-GalpNAc in which the beta-D-galactosyl group attached by a (1->4) linkage to an acetamidoglucopyranosyl group has glycosylated at its 3-hydroxy group by an alpha-D-galactopyransyl group.


cyclopropane ring

A cycloalkane ring consisting of three singly bonded carbon atoms.


cycloalkane ring

A cyclic organic group that contains only singly bonded carbon atoms.


cyclohexane ring

A cycloalkane ring consisting of six singly bonded carbon atoms.


Conjugate base of ascr#30-CoA


name: 2,4-difluorobenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester


metiram

A polymer comprising ethylenebis(dithiocarbamate) units and (ammonia)zinc(II). It is used in agriculture for the control of scab in fruit, blight in tomatoes and potatoes, and downy mildew in hops and grapes.


N-methylhippuric acid

An N-acylglycine that is N-methylglycine in which the hydrogen of the amino group is substituted by a benzoyl group.


A member of the class of furans that is furan-3(2H)-one carrying additional ethyl, hydroxy and methyl substituents at positions 2, 4 and 5 respectively. A key aroma compound in soy sauce and fish sauce.


name: N-[3-(1,3-benzodioxol-5-yl)prop-2-enylideneamino]carbamic acid tert-butyl ester


ficusequilignan A

A guaiacyl lignin that is medioresinol in which one of the phenolic hydrogens is replaced by a guaiacylglycerol group. It is found in Arabidopsis thaliana.


(R)-cyclopentolate

The (R)-enantiomer of cyclopentolate.


cyclopentolate

A carboxylic ester resulting from the formal condensation of (1-hydroxycyclopentyl)(phenyl)acetic acid with N,N-dimethylethanolamine. A tertiary amine antimuscarinic with actions similar to atropine, it is used as its hydrochloride salt to produce mydriasis (excessive dilation of the pupil) and cycloplegia (paralysis  of the ciliary muscle of the eye) for opthalmic diagnostic procedures. It acts more quickly than atropine and has a shorter duration of action.


(S)-cyclopentolate

The (S)-enantiomer of cyclopentolate.


ECKOL

A phlorotannin that is oxanthrene-1,3,6,8-tetrol substituted by a 3,5-dihydroxyphenoxy moiety at position 4. Isolated from the marine brown alga, Ecklonia cava, it exhibits antioxidant activity.


mucous neck cell of gastric gland

description: A neck cell that secretes mucus within the stomach. Its products are distinct histochemically from those of the surface mucous cells of stomach.


jejunal goblet cell

description: A goblet cell that is part of the epithelium proper of jejunum.


intestine goblet cell

description: Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3.


surface mucosal cell of stomach

description: A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall.


intestinal villus goblet cell

description: A goblet cell that is part of the epithelium of intestinal villus.


ileal goblet cell

description: A goblet cell that is part of the epithelium proper of ileum.


small intestine goblet cell

description: A goblet cell that is part of the small intestine.


lipid A

The glycolipid moiety of bacterial lipopolysaccharide (R can be either hydrogen or a fatty acyl group).


lipid A (E. coli)

The glycolipid moiety of the lipopolysaccharide produced by E. coli.


PERFLUOROCYCLOBUTANE

A fluorocarbon that is cyclobutane in which all eight hydrogens are replaced by fluorines.


Major species at pH 7.3


cochinchinone C

A polycyclic cage that is a prenylated-caged xanthone isolated from Cratoxylum cochinchinense and has been shown to exhibit antimalarial and antioxidant activities.


A member of the class of indoles that is 2-methyltryptamine in which a hydrogen attached to the primary amino group has been replaced by a 2-fluorobenzoyl group. It is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex which works by binding to Arp2/3 complex, stabilising the inactive state of the complex and preventing its movement into the active conformation.


cetrorelix

A synthetic ten-membered oligopeptide comprising N-acetyl-3-(naphthalen-2-yl)-D-alanyl, 4-chloro-D-phenylalanyl, 3-(pyridin-3-yl)-D-alanyl, L-seryl, L-tyrosyl, N(5)-carbamoyl-D-ornithyl, L-leucyl, L-arginyl, L-prolyl, and D-alaninamide residues coupled in sequence. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast.


versiconal hydroxyaldehyde form

The tricyclic anthraquinone-hydroxyaldehyde form of versicolorone.


An amino trisaccharide consisting of beta-D-mannopyranosyl, 2-acetamido-beta-D-glucopyranosyl and 2-acetamido-D-glucopyranosyl residues joined sequentially by (1->4) glycosidic linkages.


kidney cortex artery cell

description: Any kidney arterial blood vessel cell that is part of some renal cortex artery.


arcuate artery cell

description: Any kidney cortex artery cell that is part of some kidney arcuate artery.


interlobular artery cell

description: Any kidney cortex artery cell that is part of some interlobular artery.


name: microfold cell of epithelium proper of small intestine

description: A M cell that is part of the epithelium proper of small intestine.


CDP-alpha-D-glucose

A CDP-D-glucose having alpha-configuration at the anomeric centre.


cadmium telluride nanocrystal

A nanocrystal consisting of cadmium telluride.


snake-eye red 900

A nanocrystalline cadmium telluride fluorescent dye with an emission wavelength of 878 nm.


adams apple red 680

A nanocrystalline cadmium telluride fluorescent dye with an emission wavelength of 680 nm.


hemo red 720

A nanocrystalline cadmium telluride fluorescent dye with an emission wavelength of 720 nm.


luteolin

A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers.


paxanthonin

A member of the class of xanthones that is 9H-xanthen-9-one substituted by a 2,2-dimethyl-4-(prop-1-en-2-yl)cyclopentyl group at position 2, hydroxy groups at positions 1, 3 and 6 and a methoxy group at position 5. It is isolated from the callus of Hypericum perforatum and exhibits antioxidant and antimicrobial activities.


A glycoheptaosylceramide having beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycoheptaosyl component.


polysorbate 20

A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by a dodecanoyl group.


Gly-Gly-Ile zwitterion

A tripeptide zwitterion resulting from the transfer of a proton from the carboxy group to the amino group of Gly-Gly-Ile. Major microspecies at pH 7.3.


A heparin hexasaccharide consisting of 4-deoxy-2-O-sulfo-L-threo-hex-4-enopyranuronosyl, 2-deoxy-6-O-sulfo-2-(sulfoamino)-D-glucopyranosyl, 2-O-sulfo-L-idopyranuronosyl, 2-deoxy-6-O-sulfo-2-(sulfoamino)-D-glucopyranosyl, 2-O-sulfo-L-idopyranuronosyl, and 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose groups joined in sequence by alpha-(1->4) linkages. Sequence: DUAp2S(1-4)-a-D-GlcNp2S6S (1-4)-a-L-IdoAp2S(1-4)-a-D-GlcNp2S6S(1-4)-a-L-IdoAp2S(1-4)-a-D-GlcNp2S.


edelfosine

A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.


cinalukast

2,2-Diethylsuccinanilic acid substituted at a meta- position by an (E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl group. It selectively antagonizes leukotriene D4 at the cysteinyl leukotriene receptor, in the human airway, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. It is used in the treatment of asthma.


antimony-121 atom

The stable isotope of antimony with relative atomic mass 120.903818, 57.2 atom percent natural abundance and nuclear spin 5/2.


antimony-123 atom

The stable isotope of antimony with relative atomic mass 122.904216, 42.8 atom percent natural abundance and nuclear spin 7/2.


cobalt(II)-factor IV

A cobalt-corrinoid heptacarboxylic acid that is produced by Salmonella typhimurium.


deoxyviolacein

A member of the class of oxindoles resulting from formal oxidative coupling between the 3-position of 1,3-dihydro-2H-indol-2-one and the 3-position of 1,3-dihydro-2H-pyrrol-2-one, which is substituted at the 5 position by a 1H-indol-3-yl group, where the newly-formed double bond has E configuration.


Any glycosyloxyflavone that consists of a flavonol attached to a rhamnosylglucosyl residue at position 3 via a glycosidic linkage.


name: 2-[[(4-methyl-1-piperazinyl)-sulfanylidenemethyl]amino]benzene-1,4-dicarboxylic acid dimethyl ester


3-(2,3-dihydroxyphenyl)propanoic acid

A monocarboxylic acid that is propionic acid carrying a 2,3-dihydroxyphenyl substituent at C-3; a microbial metabolite of quinoline.


A polysaccharide derivative comprising a trisaccharide repeating unit consisting of N-acetyl-beta-D-mannosaminouronic acid, 3,N-diacetyl-alpha-L-fucosamine and N-acetyl-beta-D-fucosamine residues linked sequentially (1->4) and (1->3), with the trisaccharide repeats themselves being linked (1->4); corresponds to the serotype 5 (CP5) capsular polysaccharide of Staphylococcus aureus.


A polysaccharide derivative comprising a trisaccharide repeating unit consisting of N-acetyl-beta-D-mannosaminouronic acid, N-acetyl-alpha-L-fucosamine and N-acetyl-beta-D-fucosamine residues linked sequentially (1->4) and (1->3), with the trisaccharide repeats themselves being linked (1->4); corresponds to the de-O-acetylated serotype 5 (CP5) capsular polysaccharide of Staphylococcus aureus.


side of membrane

description: A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface.


cytoplasmic side of membrane

description: The side of a membrane that faces the cytoplasm.


periplasmic side of plasma membrane

description: The side (leaflet) of a plasma membrane that faces the periplasm, and all proteins embedded in it or attached to its surface.


lumenal side of membrane

description: Any side (leaflet) of a membrane that faces the lumen of an organelle.


name: cytoplasmic side of plasma membrane, cell tip

description: The leaflet the plasma membrane at the cell tip that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.


external side of apical plasma membrane

description: The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.


name: cytoplasmic side of dendritic spine plasma membrane

description: The leaflet of the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface surrounding a dendritic spine.


name: cytoplasmic side of smooth endoplasmic reticulum membrane

description: The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the cytoplasm.


name: cytoplasmic side of rough endoplasmic reticulum membrane

description: The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm.


A member of the class of benzaldehydes that is benzaldehyde substituted by a fluoro group at position 3.


flavonol 3-O-D-xylosyl-D-glucoside

A glycosyloxyflavone that consists of flavonol attached to a D-xylosyl-D-glucosyl residue at position 3 via a glycosidic linkage.


(-)-gynuraone

A   chromanone  that is 2,3-dihydro-4H-chromen-4-one substituted by hydroxy groups at positions 3 and 5 and a methyl group at position 2 (the 2R,3R stereoisomer). Isolated form the endophytic fungus Microdiplodia species, it exhibits antibacterial activity.


TERNSTROSIDE C

A beta-D-glucoside with 2-(3,4-dihydroxyphenyl)ethoxy residue at the anomeric position and a [(3,4-dihydroxyphenyl)acetyl]oxy residue at position 3. Isolated from Ternstroemia japonica, it exhibits antioxidant activity.


fatty acid 16:2

Any polyunsaturated fatty acid containing 16 carbons and 2 double bonds.