corynoline

A benzophenanthridine alkaloid that is chelidonine substituted by a methyl group at position 13. Isolated from the aerial parts of Corydalis incisa, it acts as an acetylcholinesterase inhibitor and also exhibits antineoplastic and hepatoprotective activity.


Any member of the class of coumarins that contains a 7-amino-2H-chromen-2-one skeleton.


norcoclaurine

A benzylisoquinoline alkaloid based on a  benzyltetrahydroisoquinoline skeleton.


name: 1-[(5,7-dimethyl-3-pyrazolo[1,5-a]pyrimidinyl)-oxomethyl]-4-piperidinecarboxylic acid ethyl ester


name: N-[[1-[3-(4-methylphenoxy)propyl]-3-indolyl]methylideneamino]carbamic acid ethyl ester


(R)-N-methylcoclaurinium

The conjugate acid of (R)-N-methylcoclaurine arising from protonation of the tertiary amino group; major species at pH 7.3.


SUBEROSIN

A member of the class of coumarins in which the coumarin ring is substituted at positions 6 and 7 by a 3-methylbut-2-en-1-yl group and a methoxy group, respectively. A natural product found in Citropsis articulata.


dithiolopyrrole

A heterobicyclic compound that is any dithiole ortho-fused with a pyrrole ring.


cefminox

A second-generation cephamycin antibiotic having [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl and 2-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}acetamido side-groups located respectively at positions 3 and 7beta of the cephem nucleus. A broad-spectrum bactericide, it is especially effective against Gram-negative and anaerobic bacteria.


benzofurochromene

An organic heteropolycyclic compound whose skeleton consists of a chromene ring fused onto a 1-benzofuran ring, together with their substituted derivatives.


name: 2-fluorobenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester


A benzophenanthridine alkaloid comprising dihydrosanguinarine carrying a hydroxy substituent at the 10-position.


tetraphene

An angular ortho-fused polycyclic arene consisting of four fused benzene rings.


An oxopurine that is guanine in which the hydrogen at position 8 is replaced by an oxo group and in which the nitrogens at positions 7 and 9 each bear a hydrogen.


anthrapyrazole

Any organic heterotetracyclic compound consisting of a pyrazole ring ortho-fused to an anthracene.


Major microspecies at pH 7.3.


heteropolycyclic compound

A polycyclic compound in which at least one of the rings contains at least one non-carbon atom.


seco-pregnane

Any seco-steroid based on a pregnane skeleton.


methylindole

Any member of the class of indoles carrying one or more methyl substituents.


ladderane

Any carbopolycyclic compound comprising of two or more cyclobutane rings fuse together to form a series of varying lengths. These compounds have been found to occur naturally in certain anaerobic bacteria of the phylum Planctomycetes.


s-indacenes

Molecular entities containing an s-indacene skeleton.


The (25S)-steroisomer of 5alpha-spirostan.


name: 2-[(3,4,8-trimethyl-2-oxo-1-benzopyran-7-yl)oxy]acetic acid prop-2-enyl ester


sulfobromophthalein

An organosulfonic acid that consists of phthalide bearing four bromo substituents at positions 4, 5, 6 and 7 as well as two 4-hydroxy-3-sulfophenyl groups both located at position 1.


luzindole

A member of the class of indoles that is tryptamine in which one of the amino hydrogens is replaced by an acetyl group while the hydrogen at position 2 is replaced by a benzyl group.


nitrazepam

A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome).


CEFALORAM

A cephalosporin derivative with potent antibacterial activity which binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division, inactivation of which interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in the weakening of the bacterial cell wall and causing cell lysis.


cefadroxil

A cephalosporin bearing methyl and  (2R)-2-amino-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.


SCIADOPITISIN

A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone.


cefroxadine

A first-generation cephalosporin antibiotic having methoxy and [(2R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetyl]amino side groups located at positions 3 and 7 respectively.


A  neolignan isolated from the stems of Sinocalamus affinis.


name: 1H-indazole-3-carboxylic acid 4-(1,3-dioxo-2-isoindolyl)butyl ester


CYTOGLOBOSIN E

A cytochalasan alkaloid found in Chaetomium globosum.


methyladenine

Any member of the class of 6-aminopurines that is adenine bearing a single methyl substituent.


xanthene dye

A dye derived by condensation of phthalic anhydride with resorcinol (and derivatives) or m-aminophenol (and derivatives).


purines

A class of imidazopyrimidines that consists of purine and its substituted derivatives.


A dimethylnaphthalene carrying methyl groups at positions 1 and 2.


cycloartane derivative

Any steroid (or derivative) based on a cycloartane skeleton.


name: 3-[(2-oxo-1-benzopyran-4-yl)thio]-2-butenoic acid ethyl ester


(Z)-indol-3-ylacetaldehyde oxime

An indol-3-ylacetaldehyde oxime in which the oxime moiety has Z configuration.


An L-glutamic acid derivative that is the amide obtained by formal condensation of the alpha-carboxy group of L-glutamic acid with the amino group of 2-naphthylamine.


ISOGINKGETIN

A biflavonoid resulting from the formal oxidative dimerisation between position 8 of one molecule of 5,7-dihydroxy-4'-methoxyflavone and the 3' position of another. Found in the leaves of Ginkgo biloba, it is a potent inhibitor of matrix metalloproteinase 9 (MMP-9).


(R)-dyphylline

The (R)-enantiomer of dyphylline.


The pteridine that is lumazine reduced across the C-6,C-7-double bond and substituted with a hydroxymethyl group at C-6 and a 1-D-ribityl group at N-8.


PHTHALIMIDE

A  dicarboximide that is 2,3-dihydro-1H-isoindole substituted by oxo groups at positions 1 and 3.


name: N-[4-[(4,4-diethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-oxo-1-benzopyran-7-yl]carbamic acid ethyl ester


A member of the class of indoles that is 1H-indole which is substituted by a propyl group at position 3 and by a sulfomethyl group at position 5.


name: (24R)ergosta-7, 22E-diene-3beta, 5alpha, 6beta-triol-3-O-palmitate


name: 4-morpholinecarboxylic acid [4-[6-amino-5-cyano-3-(4-methylphenyl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]phenyl] ester


(2S,3R,11R)-aszonalenin zwitterion

Major microspecies at pH 7.3.


ambiguine H

An ambiguine which is a (6aS,9R,10R,10aS)-9-ethenyl-10-isocyano-6,6,9-trimethyl-1-(2-methylbut-3-en-2-yl) substituted derivative of 2,6,6a,7,8,9,10,10a-octahydronaphtho[1,2,3-cd]indole. An antimicrobial agent isolated from the cyanobacterium strain, Fischerella.


A member of the class of naphthalenediols that is naphthalene-1,4-diol substituted at position 2 by a phytyl group.


A cis-1,2-dihydroxy-1,2-dihydro-7-methylnaphthalene that has 1R,2S-configuration.


ROBUSTAFLAVONE

A biflavonoid that is obtained by oxidative coupling of two molecules of  apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-6 of the chromene ring. Isolated from Thuja orientalis and Rhus succedanea it exhibits antioxidant, cytotoxic and anti-hepatitis B activity.


PAULLONE

An indolobenzazepine that is 5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine carrying an oxo substituent at position 6.


Any member of the class of pteridines in which the the pteridine ring has been reduced by the formal addition of one molecule of hydrogen to positions 6 and 7.


A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole substituted by a 2-hydroxyphenyl group at position 2.


OCHRINDOLE A

A bisindole alkaloid that is phenol bearing a 3,3-dimethylallyl group at position 4, two methoxy groups at positions 3 and 6, and two indol-3-yl groups at positions 2 and 5. It is a natural product isolated from the sclerotia of Aspergillus orbraceus, with moderate activity against some insects, as well as Gram-positive bacteria.


dihydroscopoletin hexoside

R=hexoside


name: 4-[3-oxo-1-(3,4,5-trimethoxyanilino)-1H-isoindol-2-yl]-1-piperidinecarboxylic acid ethyl ester


A  neolignan isolated from the stems of Sinocalamus affinis.


name: (2S*, 4R*, 8R*, 1′S*)4,8-dihydroxy-2-(1-hydroxyheptyl)-3,4,5,6,7,8-hexahydro-2H-1-benzopyran-5-one


ambiguine I

An ambiguine that consists of a 5,5,7,10,10-pentamethyl-4,5,5a,6a,6b,7,8,9,9a,10-decahydro-10dH-6-oxa-4-azacyclopropa[6,7]cyclohepta[1,2,3,4-mno]aceanthrylen-10d-ol skeleton with an ethenyl substituent at position 7 and an isocyano group at position 6b (the 5aS,6aR,6bR,7R,9aR,10dR stereoisomer). An antimicrobial agent isolated from the cyanobacterium strain Fischerella.


oxindoles

Any member of the class of indolones whose structure is based on an oxindole (2-indolone) skeleton.


A 2-demethylmenaquinol whose structure comprises a benzohydroquinone nucleus and a side chain of thirteen isoprenoid units.


HINOKIFLAVONE

A biflavonoid that is apigenin substituted by a 4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy group at position 6. A diflavonyl ether, it is isolated from Rhus succedanea and has been found to possess significant cytotoxic potential.


A tetrapeptide compound with a succinyl group at the N-terminal and a 7-amino-4-methylcoumarin group at the C-terminal.


20-hydroxy steroid

Any hydroxy steroid that in which the steroid skeleton contains a hydroxy substituent at position 20.


imidazotetrazine

Any organic heterobicyclic compound containing ortho-fused imidazole and tetrazine rings.


oxacephem

Any member of the oxacephem sub-group of cephem antibiotics, in which the thiaazabicyclo moiety of the cephalosporins is replaced by an oxaazabicyclo moiety, and  where R3 is -H or -OCH3.


PEDUNCULOSUMOSIDE E

A homoflavonoid glycoside that is ophioglonol attached to a 2-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl and beta-D-glucopyranosyl residues at positions 7 and 4' respectively via glycosidic linkages. It has been isolated from the whole plants of Ophioglossum pedunculosum.


CASTANOSPERMINE

A tetrahydroxyindolizidine alkaloid that consists of octahydroindolizine having four hydroxy substituents located at positions 1, 6, 7 and 8 (the 1S,6S,7R,8R,8aR-diastereomer).


A  flavonolignan  isolated from the stems of Sinocalamus affinis.


name: 2,3-dihydro-1,4-benzodioxin-6-carboxylic acid [2-(2,5-dichloroanilino)-2-oxoethyl] ester


A member of the class of naphthalenediols that is 1,2-dihydronaphthalene substituted by hydroxy groups at positions 1 and 2 respectively.


name: 3-amino-4-thiophen-2-yl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxylic acid methyl ester


CATECHIN

Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.


name: 5-bromo-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-2-benzofurancarboxylic acid ethyl ester


SALCOLIN B

A  flavonolignan isolated from the stems of Sinocalamus affinis.


benzofuran antifungal drug

Any member of the class of benzofurans which has been used as an antifungal drug.


chromenol

Any chromene carrying one or more hydroxy substituents.


2-naphthyl beta-D-glucoside

A beta-D-glucoside that is beta-D-glucopyranose in which the anomeric hydroxy hydrogen is replaced by a 2-naphthyl group.


name: 3',4'-Methylenedioxy epicatechin 5,7-dimethyl ether


homoflavonoid glycoside

A homoflavonoid  having one or more glycosyl residues attached at unspecified positions.


A  homoisoflavonoid that is 3,4-dihydro-2H-1-benzopyran substituted by hydroxy groups at positions 3, 4 and 7 and a (4-hydroxyphenyl)methyl group at position 3 respectively (the 3R,4R-stereoisomer). It has been isolated from Caesalpinia sappan.


ISOGUANINE

An oxopurine that is 3,7-dihydro-purin-2-one in which the hydrogen at position 6 is substituted by an amino group.


name: 5-bromo-2-thiophenecarboxylic acid 1,3-benzothiazol-2-ylmethyl ester


emedastine

1-Methyl-1,4-diazepane in which the hydrogen attached to the nitrogen at position 4 is substituted by a 1-(2-ethoxyethyl)-1H-benzimidazol-2-yl group. A relatively selective histamine H1 antagonist, it is used as the difumatate salt for allergic rhinitis, urticaria, and pruritic skin disorders, and in eyedrops for the symptomatic relief of allergic conjuntivitis.


A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).


name: 2-(4-chlorophenyl)-5-methyl-4-oxo-2,3-dihydro-1H-thieno[3,4-d]pyrimidine-7-carboxylic acid ethyl ester


A  neolignan isolated from Sinocalamus affinis.


triamterene

Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.


(S)-tetrindole

An 8-cyclohexyl-2,3,3a,4,5,6-hexahydropyrazino[3,2,1-jk]carbazole that is the (S)-enantiomer of tetrindole.


Pterin acetylated on N-2 and carrying a formyl group at position 6.


acenaphthenes

Any member of the class of acenaphthylenes based on a acenaphthene skeleton and its derivatives.


A pteridine that is lumazine substituted with a 5-hydroxypentyl group at position 8 and a methyl group at position 7; one of 20 modifications to the potent microbial riboflavin-based metabolite antigen 5-(2-oxopropylideneamino)-6-D-ribityl aminouracil (5-OP-RU), an activator of mucosal-associated invariant T (MAIT) cells when presented by the MR1 protein (reported in MED:32123373).


A ketone hydrate that is naphthalene-1,2,3,4-tetrone in which water has been added to the keto groups at positions 2 and 3. It has been used as an antiviral agent in nasal ointment.


An N-(2-naphthyl)carboxamide obtained by formal condensation of the C-terminal carboxy group of N-glutaryl-L-phenylalanine with the amino group of 2-naphthylamine.


name: 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester


epinastine

A benzazepine that is 6,11-dihydro-5H-dibenzo[b,e]azepine in which the azepine ring is fused to the e side of 4,5-dihydro-1H-imidazol-2-amine.


A carboxynaphthofluorescein compound having a carboxy substituent at the 5-position.


name: 5-[(6-methoxy-1,3-benzothiazol-2-yl)amino]-3-methyl-2-thiophenecarboxylic acid ethyl ester


name: cyclopropanecarboxylic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester


varenicline

An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking.


A member of the class of naphthalenediols that is 1,2-dihydronaphthalene substituted by hydroxy, hydroxy and methyl groups at position 1, 2 and 7, respectively.


An X-rhodamine compound having a carboxy substituent at the 5-position.


Compounds based on a fused 1,2-oxazole and benzene bicyclic ring skeleton, with the O atom positioned adjacent to one of the positions of ring fusion.


6beta-hydroxy steroid

Any 6-hydroxy steroid in which the 6-hydroxy substituent has beta-configuration.


name: 4-[[2-(dimethylamino)-2-thiophen-2-ylethyl]amino]-5-methyl-6-thieno[2,3-d]pyrimidinecarboxylic acid ethyl ester


16-hydroxy steroid

Any hydroxy steroid carrying a hydroxy group at position 16.


N-phthaloyl-L-glutamic acid

A glutamic acid derivative that is L-glutamic acid in which the two hydrogens on the amino group are substituted by a phthaloyl group.


tetralins

Compounds containing a tetralin skeleton.


epigallocatechin

A flavan-3,3',4',5,5',7-hexol having (2R,3R)-configuration.


purine N-oxides

Any N-oxide of a purine or purine derivative.


EUGENIN

A member of the class of  chromones that is chromone substituted by a hydroxy group at position 5, a methoxy group at position 7 and a methyl group at position 2. It has been isolated from Pisonia aculeata.


name: 4-chlorobenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester


name: 2-(6-imidazo[2,1-b]thiazolyl)acetic acid 1,3-benzothiazol-2-ylmethyl ester


Any hydroxyflavan containing a 3-hydroxy group and having 2S,3R stereochemistry.


cephalosporin

A class of beta-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring.  Although cephalosporins are among the most commonly used antibiotics in the treatment of routine infections, and their use is increasing over time, they can cause a range of hypersensitivity reactions, from mild, delayed-onset cutaneous reactions to life-threatening anaphylaxis in patients with immunoglobulin E (IgE)-mediated allergy.


LARICYTRIN

A monomethoxyflavone that is the 3'-O-methyl derivative of myricetin.


name: (-)-Epigallocatechin 3-gallate 7-glucoside 4"-glucuronide


indoleacetic acid conjugate

A conjugated form of indole-3-acetic acid.  There are two types of indoleacetic acid conjugates: ester and amide conjugates. The ester conjugates are formed with sugars or polyols through an ester bond, whereas the amide conjugates are formed with amino acids or polypeptides through an amide bond.


A mononitronaphthalene substituted by a nitro group at position 1.


A methylhypoxanthine that is hypoxanthine with the methyl group at position 3.


N,alpha-dimethyltryptamine

A tryptamine derivative having methyl substituents at the N-and alpha-positions of the aminoethyl side-chain.


A methylguanine in which the methyl group is located at the N2-position.


name: 1-oxo-2-benzothiopyran-3-carboxylic acid methyl ester


macarpine

A benzophenanthridine alkaloid that is sanguinarine bearing two methoxy substituents.


GINKGETIN

A biflavonoid that is the  7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxygenase 2.


CRYPTOLEPINE

An organic heterotetracyclic compound that is 5H-indolo[3,2-b]quinoline in which the hydrogen at position N-5 is replaced by a methyl group.


isochaetoglobosin D

A cytochalasan alkaloid found in Chaetomium globosum.


abacopterin B

An organic heterotetracyclic compound resulting from cyclocondensation of the 4- and 5-hydroxy groups of (2S,4S)-2-(4-methoxyphenyl)-6,8-dimethylchromane-4,5,7-triol across the 1- and 2-positions of 3-O-acetyl-1,2-didehydro-D-glucose. A natural product found in Abacopteris penangiana.


furopyran

Any organic heterobicyclic compound containing ortho-fused furan and pyran rings.


cefaclor

A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.


indacenes

Molecular entities containing an indacene skeleton.


name: N-[(4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-9-yl)methyl]carbamic acid (phenylmethyl) ester


name: acetic acid [4-[acetyl-(4-chlorophenyl)sulfonylamino]-1-naphthalenyl] ester


cefdinir

A cephalosporin compound having 7beta-2-(2-amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino- and 3-vinyl side groups.


cholestane ester

Any steroid ester based on a cholestane skeleton.


isostrychnine N-oxide

A monoterpenoid indole alkaloid with formula C21H22N2O3, originally isolated from the seeds of Strychnos nux-vomica.


loracarbef zwitterion

The zwitterionic form of loracarbef.


L-cysteine 2-naphthylamide

An L-cysteine derivative that is the amide obtained by formal condensation of the carboxy group of L-cysteine with the amino group of 2-naphthylamine.


benzoselenazole

An organic heterobicyclic compound whose skeleton consists of a benzene ring which is ortho-fused to a selenzole ring.


A benzothiazole consisting of a benzene ring fused to an isothiazole.


(+)-conocarpan

A member of the class of benzofurans that is 2,3-dihydro-1-benzofuran substituted by a methyl group at position 3, a prop-1-en-1-yl group at position 5 and a 4-hydroxyphenyl group at position 2. It is a lignan derivative isolated from the roots of Krameria lappacea.


dyphylline

An oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs.


DIBROMOBIMANE

A pyrazolopyrazole that consists of 1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione bearing two methyl substituents at positions 2 and 6 as well as two bromomethyl substituents at positions 3 and 5.


name: 4-oxo-2-(trifluoromethyl)-1H-thieno[3,4-b]pyridine-7-carboxylic acid methyl ester


A sialomonoglycosylceramide having N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl as the sialomonoglycosyl component.


An isocyanate that is diphenylmethane with a isocyanato substituent at the 4-position of one phenyl ring and a methyl group at the 4-position of the other.


(7-methyloctyl)sulfamic acid

A member of the class of sulfamic acids that is sulfamic acid in which one of the amino hydrogens has been replaced by a (7-methyloctyl) group.


An alkene that is but-1-ene carrying a methyl substituent at position 3.


glycylpeptide zwitterion

A peptide zwitterion that is the zwitterionic form of a glycylpeptide where the amino terminus is positively charged and the carboxy terminus is negatively charged.


(3S)-3-hydroxy-L-histidine residue

An L-alpha-amino acid residue derived from (3S)-3-hydroxy-L-histidine.


lytic vacuole membrane

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell.


cytolytic granule membrane

description: The lipid bilayer surrounding the cytolytic granule.


autolysosome membrane

description: A lipid bilayer that surrounds an autolysosome, a single-membrane-bounded vesicle in which endogenous cellular material is degraded.


name: N-[3-carbamoyl-5-[diethylamino(oxo)methyl]-4-methyl-2-thiophenyl]carbamic acid methyl ester


fluvastatin sodium

A racemate that is the sodium salt of fluvastatin. An HMG-CoA reductase inhibitor, it is used to reduce triglycerides and LDL-cholesterol, and increase HDL-chloesterol, in the treatment of hyperlipidaemia.


anthracycline antibiotic

An organic compound that has a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine and which exhibits antibiotic activity.


aminal

Compounds having two amino groups bonded to the same carbon, R2C(NR2)2.


CALYCANTHINE

The principal alkaloid of the plant family Calycanthaceae.


A glycosylgalactose consisting of an alpha-L-fucopyranose residue and a D-galactopyranose residue joined in sequence by a (1->6) glycosidic bond.


An alpha-L-Fucp-(1->6)-D-Galp in which the carbon bearing the anomeric hydroxy group has beta configuration.


A branched amino oligosaccharide comprising a linear trisaccharide of beta-D-mannosyl and two N-acetyl-beta-D-glucosaminyl residues all linked in sequence (1->4), to the mannosyl residue of which are (1->3)- and (1->6)-linked two identical branches consisting of N-acetyl-alpha-neuraminyl, beta-D-galactosyl, N-acetyl-beta-D-glucosaminyl and alpha-D-mannosyl residues linked in a (2->3), (1->4) and (1->2) sequence.


Phe-His zwitterion

A dipeptide zwitterion obtained by transfer of a proton from the carboxy to the amino terminus of Phe-His. Major species at pH 7.3.


beta-D-Galp3S-(1->4)-[alpha-L-Fucp-(1->3)]-D-Glcp with beta configuration at the glucose anomeric centre.  A trisaccharide derivative that consists of beta-D-glucose having an alpha-L-fucosyl residue attached at position 3 and a 3-sulfated beta-D-galactosyl residue attached at position 4.


isoporphyrin

A compound which is a tautomer of porphyrin containing a saturated meso carbon atom.


tetrahydrotyrosine zwitterion

An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of tetrahydrotyrosine; major species at pH 7.3.


Ala-Pro-Gly

A tripeptide composed of L-alanine, L-proline and glycine joined in sequence by peptide linkages.


bromoporphyrin

A substituted porphyrin compound containing one or more bromine atoms.


haloporphyrin

A substituted porphyrin compound containing one or more halogen atoms.


meso-bromoporphyrin

A porphyrin compound substituted with one or more bromine atoms bonded to a methine group of the porphyrin ring.


chloroporphyrin

A substituted porphyrin compound containing one or more chlorine atoms.


aldehydo-mannose

The open chain form of mannose.


aldehydo-D-mannose

The D-enantiomer of aldehydo-mannose.


A branched amino hexasaccharide comprised of a backbone of alpha-D-mannosyl, beta-D-mannosyl, N-acetyl-beta-D-glucosaminyl and N-acetyl-beta-D-glucosamine residues linked in sequence (1->3), (1->4) and (1->4), to the beta-D-mannosyl residue is also linked (1->2) a beta-D-xylosyl residue, while to the N-acetyl-beta-D-glucosamine residue at the reducing end is also linked (1->6) an alpha-L-fucosyl residue.


aspartic acid derivative

An amino acid derivative resulting from reaction of aspartic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen of aspartic acid by a heteroatom. The definition normally excludes peptides containing aspartic acid residues.


A conjugated sterol that is produced by the tRNA-dependent addition of L-aspartate to the 3beta-OH group of ergosterol. Major microspecies at pH 7.3.


D-aspartic acid derivative

A non-proteinogenic amino acid derivative resulting from the formal reaction of D-aspartic acid at the amino group or either carboxy group, or from the replacement of any hydrogen of D-aspartic acid by a heteroatom.


hydroxycinnamoyl aspartate

R=phenoxy.


L-aspartic acid derivative

A proteinogenic amino acid derivative resulting from reaction of L-aspartic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen of L-aspartic acid by a heteroatom.


name: Quercetin 3,3'-dimethyl ether 4'-isovalerate


A melanin pigment produced by certain fungi. It plays important roles in UV protection, oxidative stress and pathogenesis. In Aspergillus fumigatus, it is used as a virulence factor and plays an important role in the survival of the fungus during unfavorable conditions both in vivo and in vitro, and protects it from the host immune system. The pigment is generally synthesised from the pentaketide pathway in which 1,8-dihydroxynaphthalene is the immediate precursor which is polymerized to 1,8-dihydroxynaphthalene-melanin by a laccase enzyme.


nocardicin G zwitterion

An amino acid zwitterion resulting from a transfer of a proton from the carboxy group to the amino group of nocardicin G; major species at pH 7.3.


An N(4)-glycosylated L-asparagine residue derived from N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-Asn.


laminaritriose

A trisaccharide consisting of three beta-(1->3)-linked D-glucopyranose units with undefined stereochemistry at the reducing end.


dehydroamino acid

An amino acid derivative that is an amino acid whose side-chain has undergone formal dehydrogenation.


A 2,3-dehydroamino acid derived from 7-chlorotryptophan.


dehydroglycine

A dehydroamino acid derived from glycine.


2,3-dehydroamino acid

A dehydroamino acid whose side-chain contains a double bond at the 2-3 position.


A hexonic acid derivative that is (4S,5R)-4,5,6-trihydroxyhexanoic acid substituted at position 2 by an imino group.


(Z)-2,3-didehydroaspartic acid

A 2,3-dehydroamino acid resulting from the formal dehydrogenation of the side chain of aspartic acid to introduce a C=C double bond at the 2-3 position.


alpha,beta-didehydrotryptophan

A dehydroamino acid that is the 2,3-didehydro derivative of tryptophan.


sugammadex

An octasaccharide derivative that is gamma-cyclodextrin in which all eight primary hydroxy groups are replaced by 2-(carboxyethyl)sulfanyl groups. Used (as the octasodium salt) for reversal of neuromuscular blockade induced by rocuronium and vecuronium in adults undergoing surgery.


organic heterocyclic compound

A cyclic compound having as ring members atoms of carbon and at least of one other element.


A tetrapeptide that is isolated from the sea hare Dolabella auricularia. It is a potent anticancer agent which inhibits tubulin polymerization.


bicoumarin

A biaryl in which both of the coupled aromatic groups consists of coumarin or a substituted coumarin.


ECONAZOLE NITRATE

A racemate composed of equimolar amounts of (R)- and (S)-econazole nitrate. Used to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections.


An organic cation that is tetrazolium substituted with a dimethylthiazolyl group and two phenyl groups. The cation exists in two resonance forms.


A 1,3-thiazole in which the only substituent is a 2-hydroxyethyl group at position 5.


inamrinone

A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.


superphthalocyanine

A cyclic pentapyrrole derivative that consists of five isoindole-type units, with the connecting carbon atoms replaced by nitrogen. The parent of the class of superphthalocyanines.


delta-lactam

A lactam in which the amide bond is contained within a six-membered ring, which includes the amide nitrogen and the carbonyl carbon.


alpha-methylhistamine

An aralkylamino compound that is histamine bearing a methyl substituent at the alpha-position.


A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.


name: N,N-dimethylcarbamic acid [4-[6-(trifluoromethyl)-2-imidazo[1,2-a]pyridinyl]phenyl] ester


name: benzenecarbothioic acid S-(5-quinolinyl) ester


The intermediate in the biosynthesis of vitamin B12 from uroporphyrinogen III in which three methyl groups have been introduced at positions 2, 7 and 20 of the tetrapyrrole framework.


thiazolines

Thiazolines (or dihydrothiazoles) are a group of isomeric 5-membered heterocyclic compounds containing both sulfur and nitrogen in the ring.


CINCHONIDINE

8-epi-Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (R configuration). A diasteroisomer of cinchonine, it occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.


yaequinolone D

Published in DOI:10.1038/ja.2006.86


aminoquinoline

Any member of the class of quinolines in which the quinoline skeleton is substituted by one or more amino or substituted-amino groups.


amicarbazone

A member of the class of triazoles that is 4,5-dihydro-1H-1,2,4-triazol-5-one which is substituted at position 1 by a tert-butylaminocarbonyl group and at position 3 by an isopropyl group. A selective herbicide for pre- and post-emergence control of annual dicotyledonous weeds and grasses, it is not approved for use within the European Union.


TILMACOXIB

A member of the class of 1,3-oxazoles that is that is 1,3-oxazole which is substituted at positions 2, 4 and 5 by methyl, cyclohexyl, and 3-fluoro-4-sulfamoylphenyl groups, respectively.


uranidine

A quinolone that is quinolin-4(1H)-one substituted by hydroxy groups at positions 3, 5, and 8. It is isolated from the sponge Aplysina aerophoba.


cytoporphyrin

A cyclic tetrapyrrole that consists of porphyrin bearing several substituents including methyl, vinyl, formyl, hydroxy and hydroxyalkatrienyl. The parent of the class of cytoporphyrins.


The first intermediate in the biosynthesis of vitamin B12 from uroporphyrinogen III, in which one methyl group has been introduced at position 2 of the tetrapyrrole framework.


beta-formylporphyrin

A porphyrin compound substituted with one or more formyl groups bonded to a pyrrole group of the porphyrin ring.


precorrin

Any of the intermediates in the biosynthesis of vitamin B12 from uroporphyrinogen III that lie on the pathway before the formation of the first corrin macrocycle. The figure after 'precorrin' corresponds to the number of C-methyl groups introduced into the tetrapyrrole framework.


tinidazole

1H-imidazole substituted at C-1 by a (2-ethylsulfonyl)ethyl group, at C-2 by a methyl group and at C-5 by a nitro group.  It is used as an antiprotozoal, antibacterial agent.


tetrathiafulvalene

A member of the class of fulvalenes that is ethene substituted by 1,3-dithiol-2-ylidene groups at positions 1 and 2.


pizotifen

A benzocycloheptathiophene that is 9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene 4-ylidene)-1-methylpiperidine which is joined from the 4 position to the 4 position of an N-methylpiperidine moiety by a double bond. It is a sedating antihistamine, with strong serotonin antagonist and weak antimuscarinic activity. It is generally used as the malate salt for the treatment of migraine and the prevention of headache attacks during cluster periods.


A triazole that is benzonitrile substituted by a (1S,2S)-3-(4-fluorophenyl)-2-hydroxy-1-(1,2,4-triazol-1-yl)propyl group at position 4.


A carbohydrate derivative consisting of beta-D-galactose having a 1-carboxyethylidene group masking the 3-and 4-positions.


octhilinone

A member of the class of 1,2-thiazole that is 1,2-thiazol-3-one substituted on the nitrogen (position 2) by an octyl group. A fungicide and antibacterial agent, it is used for treatment of canker and other fungal and bacterial diseases in fruit trees. It is no longer approved for use within the European Union.


bipyridines

Compounds containing a bipyridine group.


6-aminohexanoic acid cyclic oligomer

A macrocyclic lactam obtained by cyclo-oligomerisation of 6-aminohexanoic acid.


A triazole that is benzonitrile substituted by a (1S,2R)-3-(4-fluorophenyl)-2-hydroxy-1-(1,2,4-triazol-1-yl)propyl group at position 4.


poly[d(TCC)].poly[d(GGA)]

A double-stranded DNA polynucleotide comprising in one strand a repeating sequence of one thymidine residue and and two deoxycytidine residues, with in a complementary strand a repeating sequence of two deoxyguanosine residues and one deoxyadenosine residue, all residues in each strand being connected by 3'->5' phosphodiester linkages.


name: 5-bromo-2-furancarboxylic acid [2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl] ester


A member of the class of imidazoles that is 1H-benzimidazole in which the hydrogen at position 5 is substituted by a methyl group.


An azamacrocycle with formula C34H32N8O7S isolated from the cultured mycelium of Streptomyces nobilis. It exhibits potent cytotoxic activity against human cancer cell lines.


benzocycloheptathiophene

benzocycloheptathiophenes


cyclic sexipyridine

An azamacrocyle comprised of six linked pyridine units.


styrene oxide

An epoxide that is oxirane in which one of the hydrogens has been replaced by a phenyl group.


name: 3-[[[2-(3-methylphenyl)-4-quinolinyl]-oxomethyl]amino]-2-thiophenecarboxylic acid methyl ester


quinolines

A class of aromatic heterocyclic compounds each of which contains a benzene ring ortho fused to carbons 2 and 3 of a pyridine ring.


name: 5-amino-3-(4-methoxyphenyl)-7-methyl-4-oxo-1-thieno[3,4-d]pyridazinecarboxylic acid methyl ester


Cinchonan or its (8S)-epimer.


corrole

A tetrapyrrole fundamental parent that is the octadehydro drivative of corrin.


aztreonam

A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.


name: 7-anilino-1-(4-methylphenyl)-5-oxo-[1,2,4]triazolo[4,3-a]pyrimidine-3-carboxylic acid ethyl ester


dipyrrin

A dipyrrin that consists of pyrrole bearing a pyrrol-2-ylidenemethyl substituent at the 2-position.


N-acetylhistamine

A member of the class of acetamides that is acetamide comprising histamine having an acetyl group attached to the side-chain amino function.


bacteriochlorin

A tetrapyrrole fundamental parent that consists of two pyrrole and two reduced pyrrole units connected by methine linkages, where the two reduced pyrroles are located diagonally opposite one another.


salinosporamide

Family of cytotoxic secondary metabolites produced by the marine actinomycete Salinispora tropica.


A platinum(II) porphyrin compound having four pentafluorophenyl substituents in the 5-, 10-, 15-, and 20-positions.


A quinolone that is 1,4-dihydroquinoline substituted by an oxo group at position 4.


biphenylyltetrazole

A member of the class of biphenyls that consists of a biphenyl ring system substituted by a tetrazole ring at an unspecified position.


isoconazole nitrate

A racemate comprising equimolar amounts of (R)- and (S)-isoconazole nitrate. A broad-spectrum antibacterial drug used for treatment of dermatomycoses.


triazoles

An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.


benzopyridoquinolizidine derivative

Any compound derived from a benzopyridoquinolizidine.


lamivudine

A monothioacetal that consists of cytosine having a (2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl moiety attached at position 1. An inhibitor of HIV-1 reverse transcriptase, it is used as an antiviral in the treatment of AIDS and hepatitis B.


A member of the class of  2,2'-bithiophenes that is 2,2'-bithiophene substituted by a 3-buten-1-ynyl group at position 5.


aziridinium ion

Compounds containing an aziridine ring that contains a quaternary nitrogen atom.


A sulfonamide that is benzenesulfonamide substituted by an acetylamino group at position 4 and a 1,3-thiazol-2-yl group at the nitrogen atom. It is a metabolite of sulfathiazole.


An epoxide carrying methyl and vinyl substituents at position 2 (the R-enantiomer).


N-hydroxyhistamine

A hydroxylamine that is  histamine in which the primary amino group is replaced by a hydroxyamino group.


linear sexipyridine

A ring assembly comprised of six linked pyridine units.


fluvirucin A1

A lactam that is 4-hydroxyazacyclotetradecan-2-one substituted by an ethyl group at position 11, methyl groups at position 3 and 7 and a 3-amino-3,6-dideoxy-alpha-L-talopyranosyl moiety at position 4 via a glycosyl linkage (the 3R,4S,7R,11S stereoisomer). It is isolated from the fermentation broth of an unidentified actinomycete species and exhibits potent inhibitory activity against influenza A virus.


An aromatic ether that is quinoline substituted at position 6 by a methoxy group.


A 1,3-thiazole substituted by a methyl group at position 4.


(R)-styrene oxide

The (R)-enantiomer of styrene oxide.


(S)-oxamniquine

A {2-[(isopropylamino)methyl]-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl}methanol that has S configuration.


A synthetic dipyrrin derived from rings A and D of bilirubin IXalpha in which C-9 carries a 2-(4-sulfophenyl)diazenyl substituent.


brivaracetam

A non-proteinogenic amino acid derivative that is butanamide in which the pro-S hydrogen at position 2 is replaced by a (4R)-2-oxo-4-propylpyrrolidin-1-yl. Used for treatment of partial onset seizures related to epilepsy.


name: Brassica napus non-fluorescent chlorophyll catabolite 3


PRODIGIOSIN

A member of the class of tripyrroles that is a red-coloured pigment with antibiotic properties produced by Serratia marcescens.


OXYCARBOXIN

An anilide obtained by formal condensation of the amino group of aniline with the carboxy group of 2-methyl-5,6-dihydro-4,4-dioxo-1,4-oxathiine-3-carboxylic acid. A fungicide for the control of rust diseases on ornamentals, cereals and nursery trees as well as fairy rings on turf.


urobilinogen

A member of the class of bilanes that is a colourless product formed in the intestine by the reduction of bilirubin.


maytansinoid

Any member of the group of 19-membered lactams that is maytansine or structurally related to it. Maytansinoids have been isolated from members of the higher plant families Celastraceae, Rhamnaceae, and Euphorbiaceae, as well as some mosses and certain Actinomycetes, but the term is used to cover both naturally occurring compounds and their semisynthetic derivatives.


benzthiazide

7-Sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by chlorine and that at position 3 is substituted by a benzylsulfanylmethyl group. A diuretic, it is used to treat hypertension and edema.


name: Dimethylprotoporphyrin IX dimethyl ester


name: 2-(4-hydroxy-2-oxo-1H-quinolin-3-yl)acetic acid pentyl ester


SULBACTAM SODIUM

The organic sodium salt of sulbactam.


An N-glycosyl compound that consists of any triazole having a glycosyl residue attached at position 1.


name: 2-cyano-3-[2-(1-piperidinyl)-3-quinolinyl]-2-propenoic acid ethyl ester


name: 2-[3-(4-methoxyphenyl)-1-benzo[f]quinolinyl]acetic acid ethyl ester


metalloprotoporphyrin

A metal--protoporphyrin coordination complex.


A crown ether that is 15-crown-5 ortho-fused to a benzene ring.


name: 2-[[1-acetyl-5-oxo-4-[[4-(1,2,4-triazol-1-yl)phenyl]methylidene]-2-imidazolyl]thio]acetic acid ethyl ester


A thiophene that is substituted by methyl groups at positions 3 and 4.


arene epoxide

Any epoxide formally derived from an arene by the 1,2 addition of an oxygen atom to a double bond.


polypyrrole

A compound composed of two or more pyrrole units.


meso-borylporphyrin

A substituted porphyrin compound containing one or more groups of formula BRR' (where R or R' can be H) bonded to one or more methine groups of the porphyrin ring.


An epoxide that is oxirane substituted by propan-2-yl groups at positions 2 and 3 respectively (the 2R,3R-stereoisomer).


N-methylmesoporphyrin

A mesoporphyrin with an N-methyl substituent at the 22-position.


An oxacycle that is 4H-pyran in which the methylene group at position 4 is replaced by an oxygen. Non-aromatic.


coproporphyrin

A member of the class of porphyrins obtained during the heme biosynthesis in humans.


hydroflumethiazide

A benzothiadiazine consisting of a 3,4-dihydro-HH-1,2,4-benzothiadiazine bicyclic system dioxygenated on sulfur and carrying trifluoromethyl and aminosulfonyl groups at positions 6 and 7 respectively. A diuretic with actions and uses similar to those of hydrochlorothiazide.


(3S,5S)-carbapenam-3-carboxylic acid

A carbapenam substituted at position 3 by a carboxy group (the 3S,5S-diastereomer).


name: 4-amino-3-[(cyclohexylamino)-oxomethyl]-5-isothiazolecarboxylic acid [1-(cyclohexylamino)-1-oxopropan-2-yl] ester


(S)-styrene oxide

The (S)-enantiomer of styrene oxide.


BUTOCONAZOLE NITRATE

An organic nitrate salt obtained by reaction of equimolar amounts of butaconazole and nitric acid.  An antifungal agent, it is used in gynaecology for treatment of vulvovaginal infections caused by Candida species, particularly Candida albicans.


A bipyridine that is 3,3'-bipyridine bearing six hydroxy groups at positions 2, 2', 5, 5', 6 and 6'.


vibriobactin

A catecholate siderophore produced exclusively by Vibrio cholerae. It contains three molecules of 2,3-dihydroxybenzoate linked either directly or through L-threonine residues to the polyamine norspermidine.


name: 1-adamantanecarboxylic acid [2-(2-furanylmethylamino)-2-oxoethyl] ester


morphinane-like compound

Any organonitrogen heterocyclic compound based on a morphinan skeleton. These are synthetic or semi-synthetic compounds that resemble the  morphinane (opioid) alkaloids in their pharmacological effects.


xyloketal

A group of natural compounds isolated from the marine mangrove fungus Xylaria sp. 2508 that have multiple pharmacological and therapeutic properties.


An  amino acid amide that is a carboxamide obtained by formal condensation between N-butyl-L-cysteinamide and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid.


name: 1-(3-aminophenyl)-4-triazolecarboxylic acid methyl ester


tetrapyrrole

A natural pigment containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.


bisindole alkaloid

An alkaloid containing a bisindole skeleton.


beta-lactam antibiotic

An organonitrogen heterocyclic antibiotic that contains a beta-lactam ring.


azole

Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.


fluoxytioconazole (thione)

A racemate comprising equimolar amounts of (R)- and (S)-fluoxytioconazole (thione).


FLUTRIAFOL

A racemate comprising an equimolar mixture of (R)- and (S)-flutriafol. A systemic fungicide, it is used to control fungal diseases in cereal crops.


A member of the class of tetrazoles that is 1H-tetrazole substituted by amino groups at positions 1 and 5 respectively.


5-hydroxyimidazole-4-acetic acid

A hydroxyimidazole that is 5-hydroxyimidazole in which the hydrogen at position 4 is replaced by a carboxymethyl group.


fluoroquinolone antibiotic

An organonitrogen heterocyclic antibiotic containing a quinolone (or quinolone-like) moiety and which have a fluorine atom attached to the central ring system.


yaequinolone C

Published in DOI:10.1038/ja.2006.86


meso-substituted porphyrin

A porphyrin compound which is substituted via the methine groups in the porphyrin ring.


(S)-bendroflumethiazide

The (S)-enantiomer of bendroflumethiazide.


name: 2-[(7-ethyl-[1,3]dioxolo[4,5-g]quinolin-6-yl)thio]acetic acid propan-2-yl ester


An aralkylamino compound that is histamine bearing a methyl substituent at the 2 position on the ring.


isobacteriochlorins

Tetrahydroporphyrins in which the saturated carbon atoms are located at nonfused carbon atoms of two adjacent pyrrole rings.


NITENSIDINE E

An alkaloid that is 1,4,5,6-tetrahydropyrimidine substituted by an amino group at position 2 and by a methyl group and a 4-methylpenta-1,3-dien-1-yl group at position 6. Isolated from the leaves of Pterogyne nitens, it exhibits cytotoxicity against a panel of human cancer cell lines.


name: (6RS)-22-oxo-23,24,25,26,27-pentanorvitamin D3 6,19-sulfur dioxide adduct / (6RS)-22-oxo-23,24,25,26,27-pentanorcholecalciferol 6,19-sulfur dioxide adduct


coenzyme F430

A nickel tetrapyrrole found only in methanogenic Archaea. It is the prosthetic group of the enzyme methyl coenzyme M reductase which catalyses the release of methane in the final step of methanogenesis.


The intermediate in the biosynthesis of vitamin B12 from uroporphyrinogen III in which six methyl groups have been introduced into the tetrapyrrole framework, together with ring contraction.


oxetenes

Compounds containing an oxetene skeleton.


azaphilone

Any member of a family of natural products which contains a 6H-isochromene-6,8(7H)-dione or an isoquinoline-6,8(2H,7H)-dione skeleton and its substituted derivatives thereof.


conazole fungicide

Any conazole antifungal agent that has been used as a fungicide.


subphthalocyanines

Compounds containing a subphthalocyanine skeleton.


uniconazole

A racemate comprising equimolar amounts of uniconazole-P and its enantiomer, (R)-uniconazole.


name: 2-amino-3-cyano-5,6,7,8-tetrahydroquinoline-4-carboxylic acid methyl ester


BENTAZON

A  benzothiadiazine that is 1H-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide substituted by an isopropyl group at position 3.


arasertaconazole nitrate

An organic nitrate salt obtained by reaction of equimolar amounts of arasertaconazole and nitric acid. The active R-enantiomer of sertaconazole nitrate that is used for treatment of vulvovaginal candidiasis. The racemate itself is also used as a broad-spectrum antifungal drug.


name: 2-phenoxyacetic acid (8-methyl-2-oxo-1H-quinolin-3-yl)methyl ester


chlorothiazide

4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension.


A 1,3-thiazole that is thiazole in which all three hydrogens are replaced by methyl groups. A Maillard reaction product, it is a flavour component in many cooked foods, including cooked meats and potatoes.


A quinolone consisting of quinolin-4(1H)-one carrying a heptyl substituent at position 2 and a hydroxy group at position 3.


aminoimidazole

Any member of the class of  imidazoles carrying at least one amino substituent.


monobactam

Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotic. It lacks the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.


A member of the class of quinoline N-oxides that is 2-methyl-1-oxo-4-3,4-dihydroquinoline-3,4-diol carrying an additional (2E,6E)-farnesyl group at position 4.


A synthetic dipyrrin derived from rings A and D of bilirubin IXalpha in which C-9 carries a phenyldiazenyl substituent.


name: 5-amino-3-(2-methylphenyl)-4-oxo-1-thieno[3,4-d]pyridazinecarboxylic acid ethyl ester


phthalylsulfathiazole

A sulfonamide incorporating 2-carboxybenzamido and 1,3-thiazol-2-yl moieties that is a broad-spectrum antibiotic indicated in the treatment of dysentery, colitis, gastroenteritis and intestinal surgery.


sulconazole

A racemate comprising equimolar amounts of (R)- and (S)-sulconazole. An antifungal agent with activity against Candida species, it is used (generally as the nitrate salt) for the topical treatment of fungal skin infections.


MICONAZOLE NITRATE

A racemate composed of equimolar amounts of (R)- and (S)-miconazole nitrate. An antifungal used for the treatment of athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.


name: 2,4-dimethyl-5-[2-[[1-(4-methylphenyl)-5-tetrazolyl]thio]-1-oxoethyl]-1H-pyrrole-3-carboxylic acid ethyl ester


The intermediate in the biosynthesis of vitamin B12 from uroporphyrinogen III in which five methyl groups have been introduced into the tetrapyrrole framework, together with ring contraction.


penigequinolone B

Published in DOI:10.1038/ja.2006.86


An amino acid amide that is a carboxamide obtained by formal condensation between N-butyl-L-alaninamide and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid.


triazole fungicide

Any triazole antifungal agent that has been used as a fungicide.


name: 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-(4-ethoxyphenyl)-4-triazolecarboxylic acid ethyl ester


triazole antifungal drug

Any triazole antifungal agent that has been used for the treatment of fungal infections in humans or animals.


cyclothiazide

3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension and oedema.


biscognienyne B

A member of the class of epoxides that is (1R,6S)-7-oxabicyclo[4.1.0]hept-3-ene substituted by 3-methylbut-2-en-1-yl, hydroxy, 2-methylbut-1-en-3-yn-4-yl, and hydroxy groups at positions 1, 2R, 3 and 5R. It is a meroterpenoid natural product synthesized by the Ascomycota fungus Biscogniauxia sp.


name: 2-methyl-4-phenyl-3-quinolinecarboxylic acid ethyl ester


borylporphyrin

A substituted porphyrin compound containing one or more groups of formula BRR' (where R or R' can be H).


bifonazole

A racemate comprising equimolar amounts of R- and S-bifonazole. It is a broad spectrum antifungal drug used for the treatment of fungal skin and nail infections.


oxpoconazole fumarate

A racemate comprising equimolar amounts of (R)- and (S)-oxpoconazole fumarate. Used to control a variety of fungal diseases including Botrytis, Sclerotinia and Monilinia spp.


double-stranded DNA fragment

A nucleobase-containing molecular entity that is a fragment of a larger double-stranded DNA molecule (either naturally occurring or synthetic).


An epoxide obtained by formal epoxidation across the 2,3-double bond of (6E)-2,6,11-trimethyldodeca-2,6,10-triene


bastadin 5

A macrocyclic lactam isolated from the marine sponge Ianthella and has been shown to exhibit calcium channel modulatory activity.


An imidazole derivative containing benzyl and chloromethyl substituents at positions 1 and 2, respectively.


name: 2-thiophen-2-yl-4-quinolinecarboxylic acid (2-oxo-3-oxolanyl) ester


meso-meso-diporphyrin

A compound consisting of a porphyrin ring bonded via one of its methine groups to a methylene group on a second porphyrin ring.


porphyrins

Natural pigments containing a fundamental skeleton of four pyrrole nuclei united through the alpha-positions by four methine groups to form a macrocyclic structure.


name: 5-nitro-2-thiophenecarboxylic acid [2-oxo-2-[(phenylmethyl)amino]ethyl] ester


name: N-(2-phenyl-3-imidazo[1,2-a]pyridinyl)carbamic acid methyl ester


vancomycin aglycone

A peptide antibiotic that is vancomycin lacking the disaccharide moiety.


A polymer composed of repeating unsubstitutued pyrrole units connected at the 2- and 5-positions.


tetrazoles

An azole in which the five-membered heterocyclic aromatic skeleton contains four N atoms and one C atom.


bencarbazone

A thiocarboxamide that is benzenecarbothioamide substituted by a fluoro, 4-methyl-5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl, and (ethanesulfonyl)nitrilo groups at positions 3,4 and 6, respectively. It is a herbicide used for the post-emergent control of broad-leaved weeds in corn, cereals, and sugar cane.


monoborylporphyrin

A borylporphyrin compound containing one group only of formula BRR' (where R or R' can be H).


porfimer

The purified component of haematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins formed by ether and ester linkages of up to eight porphyrin units (n = 0-6), where R = CH(OH)Me and/or CH=CH2.


benzotriazines

Compounds based on a fused triazine and benzene ring skeleton.


name: 4-[[2-(4-methoxyphenyl)-6-imidazo[2,1-b][1,3]benzothiazolyl]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester


name: acetic acid [5-chloro-3-(3,5-dimethylhepta-1,3-dienyl)-7-methyl-6,8-dioxo-2-benzopyran-7-yl] ester


trans-dipyrrin

The trans-isomer of dipyrrin.


bendroflumethiazide

A sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group.


name: 2-thiophenecarboxylic acid [3-(4-methoxy-4-oxobutyl)-7-methyl-6,8-dioxo-2-phenyl-7-isoquinolinyl] ester


VENTURAMIDE B

An eighteen-membered homodetic cyclic peptide which is isolated from  Oscillatoria sp. and exhibits antimalarial activity against the W2 chloroquine-resistant strain of the malarial parasite, Plasmodium falciparum.


mesobiliverdin

A bilin that consists of 3,18-diethyl-2,7,13,17-tetramethyl-1,19,22,24-tetrahydro-21H-biline-8,12-dipropanoic acid bearing two oxo substituents at positions 1 and 19.


oxetanocin A

A nucleoside analogue found in Bacillus megaterium in which an adenine moiety is attached to position 2 of a of an oxetane ring which is substituted at positions 3 and 4 by hydroxymethyl groups.


name: 2-[[3-cyano-4-(5-methyl-2-furanyl)-5,6,7,8-tetrahydroquinolin-2-yl]thio]acetic acid methyl ester


name: 2-(3,4-dimethoxyphenyl)-4-quinolinecarboxylic acid (2-oxo-3-oxolanyl) ester


porphyrinogens

Hexahydroporphyrins in which the nitrogen atoms and four meso positions are saturated.


The (3Z)-isomer of phytochromobilin.


platinum(II) octaethylporphyrin

A platinum(II) porphyrin compound having eight ethyl substituents in the 2-, 3-, 7-, 8-, 12-, 13-, 17- and 18-positions.


luminmycin A

A syrbactin derivative with a 12-carbon sidechain. It exhibits a protease-inhibition activity, and is synthesized by a non-ribosomal peptide synthase in Photorhabdus luminescens.


An  aminoimidazole  that is 1H-imidazole substituted by an amino group at position 4.


name: 4-(2-furanylmethylidene)-2-methyl-5-oxo-1-prop-2-enyl-3-pyrrolecarboxylic acid methyl ester


1,3-thiazolium cation

An organic cation resulting from protonation or quaternisation at the 3-position of any 1,3-thiazole.


secnidazole

A C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by 2-hydroxypropyl and methyl groups, respectively.


nucleobase

That part of DNA or RNA that may be involved in pairing.


name: 5-[(cyclohexylamino)-oxomethyl]-4-methyl-2-[(1-oxo-2-thiophen-2-ylethyl)amino]-3-thiophenecarboxylic acid ethyl ester


carumonam

An N-sulfonated monobactam antibiotic.


FLUCARBAZONE

An N-sulfonylurea that is 3-methoxy-4-methyl-5-oxo-4,5-dihydro-1,2,4-triazole-1-carboxamide in which the carboxamide nitrogen has undergone formal condensation with the sulfonic acid group of 2-(trifluoromethoxy)benzenesulfonic acid. An acetolactate synthase inhibitor, it is used (generally as the corresponding sodium salt, flucarbazone-sodium) to control grass weeds in cereal crops.


name: 5-nitro-2-thiophenecarboxylic acid [2-oxo-2-[[oxo-[(phenylmethyl)amino]methyl]amino]ethyl] ester


The intermediate in the biosynthesis of vitamin B12 from uroporphyrinogen III in which six methyl groups have been introduced into the tetrapyrrole framework, together with ring contraction and reduction.


name: 4-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]-2-methyl-5-furo[3,2-b]pyrrolecarboxylic acid methyl ester


NOCARDAMINE

A cyclic hydroxamic acid siderophore that is produced by several bacterial species and exhibits antitumour activity.


A double-stranded DNA polynucleotide consisting of in one strand a repeating unit of thymidine and 5-methyldeoxycytosine residues, with in a complementary strand a repeating unit of deoxyguanosine and deoxyadenosine residues, all residues in each strand being connected by 3'->5' phosphodiester linkages.


name: (132S, 17S, 18S)-132-hydroxy-20-chloro-ethylpheophorbide a


oxazole

An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.


An organosulfur heterocyclic compound and an oxacycle that is a cyclohexane in which the carbon atoms at position 1 and 3 are replaced by an oxygen and sulfur atom respectively.


A 1,3-thiazole that is thiazole substituted by a methyl group at position 4 and a 2-hydroxyethyl group at position 5.


name: 4-[3-(dimethylamino)propylamino]-7,8-dimethyl-3-quinolinecarboxylic acid ethyl ester


name: 2-quinolinecarboxylic acid (4-oxo-1,2,3-benzotriazin-3-yl)methyl ester


A member of the class of quinolines that is the 1,2,3,4-tetrahydro derivative of quinoline.


PROPYLENE OXIDE

An epoxide that is oxirane substituted by a methyl group at position 2.


triazole antifungal agent

A member of the class of triazole that has significant antifungal properties.


name: 2-[[3-(4-fluorophenyl)-7-triazolo[4,5-d]pyrimidinyl]thio]butanoic acid ethyl ester


name: Capsicum annuum Fluorescent chlorophyll catabolite


CIAFTALAN

A tetrapyrrole fundamental parent that consists of four isoindole-type units, with the connecting carbon atoms in the macrocycle replaced by nitrogen.


(S)-bifonazole

A 1-[biphenyl-4-yl(phenyl)methyl]imidazole that is the S-enantiomer of bifonazole.


syrbactin

A class of azamacrocyclic natural products with a 2,7-dioxo-1,6-diazacyclododecane skeleton that includes the syringolin, glidobactin and cepafungin natural product families. In addition to their related molecular frameworks, members of the class share similar biosynthesis pathways and identical modes-of-action, being irreversible proteasome inhibitor that inhibit all three activities of eukaryotic proteasomes.


A 1H-imidazole having a methyl substituent at the N-1 position.


cinchonine

Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (S configuration). It occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.


phytochromobilin

A member of the class of bilins which functions as the chromophore of light-sensing phytochromes in plants.


crown compound

A macrocyclic polydentate compound, usually uncharged, in which three or more coordinating ring atoms are or may become suitably close for easy formation of chelate complexes with metal ions or other cationic species.


(R)-bendroflumethiazide

The (R)-enantiomer of bendroflumethiazide.


An amino trisaccharide consisting of beta-L-rhamnose at the reducing end having a 4,6-O-[(1S)-1-carboxyethylidene]-N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-D-galactosyl group attached at the 4-position.


ABAFUNGIN

A member of the class of  guanidines that is tetrahydropyrimidin-2(1H)-imine in which the hydrogen of the imino group is replaced by a thiazol-2-yl group which in turn is substituted by a 2-(2,4-dimethylphenoxy)phenyl group at position 4. It has been used for the topical treatment of fungal nail infections.


poly[d(TTC)].poly[d(GAA)]

A double-stranded DNA polynucleotide comprising in one strand a repeating sequence of two thymidine residues and and one deoxycytidine residue, with in a complementary strand a repeating sequence of one deoxyguanosine residue and two deoxyadenosine residues, all residues in each strand being connected by 3'->5' phosphodiester linkages.


thifluzamide

An aromatic amide obtained by formal condensation of the carboxy group of 2-methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid with the amino group of 2,6-dibromo-4-(trifluoromethoxy)aniline. Used to control Rhizoctonia spp. diseases on rice, potatoes, maize, grass and other crops.


xacduro

A co-packaged medication containing sulbactam sodium and durlobactam sodium. It is used for the treatment of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia, caused by susceptible isolates of Acinetobacter baumannii-calcoaceticus complex.


subphthalocyanine

A cyclic tripyrrole derivative that consists of three isoindole-type units, with the connecting carbon atoms replaced by nitrogen. The parent of the class of subphthalocyanines.


name: 2-[[5-[(2-chloroanilino)methyl]-4-phenyl-1,2,4-triazol-3-yl]thio]acetic acid ethyl ester


cilostazol

A lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substituted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group.


name: 4,5-dimethyl-2-[[oxo(thiophen-2-yl)methyl]amino]-3-thiophenecarboxylic acid ethyl ester


poly[d(TC)].poly[d(GA)]

A double-stranded DNA polynucleotide consisting of in one strand a repeating unit of thymidine and deoxycytidine residues, with in a complementary strand a repeating unit of deoxyguanosine and deoxyadenosine residues, all residues in each strand beiing connected by 3'->5' phosphodiester linkages.


An epoxide that is oxirane substituted by a phenyl group at position 3 and a 4-nitrophenyl group at position 2 (the trans-isomer).


name: 4-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]-5-furo[3,2-b]pyrrolecarboxylic acid ethyl ester


losartan

A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position


An imidazole compound having a chloro substituent at the 2-position.


A 1,3-thiazole in which the hydrogen at position 2 has been replaced by an isobutyl group. A food flavour component with a green note that adds the characteristics of ripe tomatoes. Used in blackcurrent, papaya, melon, raspberry, and roast beef flavours, it also enhances the flavour of fresh lime.


name: 4-[2-(dimethylamino)ethylamino]-3-benzo[h]quinolinecarboxylic acid ethyl ester


cabozantinib

A dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer.


(1S,2R)-naphthalene 1,2-oxide

A naphthalene 1,2-oxide (the 1S,2R-stereoisomer).


cobalt-sirohydrochlorin

A metalloporphyrin that is sirohydrochlorin in which the four nitrogen atoms are bound to a central cobalt atom.


camphorsulfonates

Any salt or ester of camphorsulfonic acid.


A secondary carboxamide resulting from the formal condensation of the carboxy group of 4-isopropoxybenzoic acid with the primary amino group of 2-methylquinolin-8-amine. An allosteric activator of sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA).


beta-lactam

A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon.


A C-nitro compound that is imidazole bearing a nitro substituent at position 5.


name: 4-[[3-cyano-4-methyl-6-(3-pyridinyl)-2-pyridinyl]thio]-3-oxobutanoic acid ethyl ester


mesoporphyrin IX

A member of the class of mesoporphyrins obtained by formal hydrogenation of the two vinyl groups in protoporphyrin.


cyclic acetal

An acetal in the molecule of which the acetal carbon and one or both oxygen atoms thereon are members of a ring.


bitertanol

A diastereoisomeric mixture composed of the enantiomeric pair (1R,2S)- and (1S,2R)-bitertanol in a 4:1 ratio with the enantiomeric pair (1R,2R)- and (1S,2S)-bitertanol. A fungicide used to control a range of diseases including scab, powder mildew, rusts and blackspot. It is moderately toxic to most animal and insect species but is non-toxic to honeybees.


cyclic hydroxamic acid

A lactam having a hydroxy substituent on the amide nitrogen.


TIRAPAZAMINE

A member of the class of benzotriazines that is 1,2,4-benzotriazine carrying an amino substituent at position 3 and two oxido substituents at positions 1 and 4.


biladienes

Compounds based on a biladiene skeleton.


name: 4-fluorobenzoic acid 4-[[5-(5-quinolinyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester


epoxide

Any cyclic ether in which the oxygen atom forms part of a 3-membered ring.


zirconacycle

An organic heterocyclic compound in which the heteroatom(s) is zirconium.


A quinolone consisting of quinolin-4(1H)-one carrying a heptyl substituent at position 2.


The intermediate in the biosynthesis of vitamin B12 from uroporphyrinogen III in which four methyl groups have been introduced at positions 2, 7, 17 and 20 of the tetrapyrrole framework, together with ring contraction of the framework forming a bond between C-1 and C-19, leaving C-20 as part of an acetyl group bonded to C-1.


(S)-flutriafol

A 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol that has R configuration.


bacteriopheophytin

A cyclic tetrapyrrole comprising any bacteriochlorophyll molecule with two hydrogen atoms replacing the magnesium centre.


double-stranded DNA polynucleotide

A nucleobase-containing molecular entity with a polymeric structure comprised of two complementary DNA polynucleotide strands linked by hydrogen bonding.


quinolone antibiotic

An organonitrogen heterocyclic antibiotic whose structure contains a quinolone or quinolone-related skeleton.


tetraborylporphyrin

A substituted porphyrin compound containing four groups of formula BRR' (where R or R' can be H).


name: 3-[2-(cyclohexylamino)-4-(4-methoxyphenyl)-5-thiazolyl]propanoic acid methyl ester


pre-pseudomonine

A hydroxamic acid resulting from the formal condensation of the carboxy group of (4S,5R)-2-(2-hydroxyphenyl)-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid with N-hydroxy-2-(1H-imidazol-4-yl)ethanamine. It is a biosynthetic intermediate in the synthesis of pseudomonine.


name: 1-(8-quinolinylsulfonyl)-3-piperidinecarboxylic acid ethyl ester


methylisothiazolinone

A 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product Kathon(TM).


azocyclotin

A member of the class of triazoles that is 1,2,4-triazole substituted at position 1 by a tricyclohexylstannyl group.


name: 2-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)thio]acetic acid methyl ester


name: 2-thiophenecarboxylic acid (6-methyl-2-oxo-1H-quinolin-3-yl)methyl ester


(1R,2S)-naphthalene 1,2-oxide

A naphthalene 1,2-oxide (the 1R,2S-stereoisomer).


beta-beta-diporphyrin

A compound consisting of a porphyrin ring bonded via one of its pyrrole groups to a pyrrole group on a second porphyrin ring.


imidazole antifungal drug

Any imidazole antifungal agent that has been used for the treatment of fungal infections in humans or animals.


name: 3-(3-methylbut-2-enyl)-4-(3-methylbut-2-enyloxy)quinolin-2(1H)-one (Structural isomer of Buchapine)


name: N-[1-(2-furanyl)ethylideneamino]carbamic acid tert-butyl ester


thiazide

Heterocyclic compound with sulfur and nitrogen in the ring.


phorbine

A cyclic tetrapyrrole that consists of porphyrin that has a cyclopentane ring fused to one of the pyrrole rings and the adjacent methine group. The parent of the class of phorbines.


quininib

A styrylquinoline that is trans-2-styrylquinoline in which the the phenyl group has been substituted at position 2 by a hydroxy group. It is an anti-angiogenic compound that exerts a dose-dependent antagonism of the cysteinyl leukotriene pathway, preferentially antagonising cysteinyl leukotriene receptor 1. The major species at pH 7.3


Imidazole substituted at position 4 by a methyl group.


name: N-[1-methyl-3-(trifluoromethyl)-5-thieno[2,3-c]pyrazolyl]carbamic acid 2,2-dimethylpropyl ester


oxetanes

Any oxacycle that is oxetane or its substituted derivatives.


batimastat

A secondary carboxamide resulting from the formal condensation of the carboxy group of (2S,3R)-5-methyl-3-{[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-2-[(thiophen-2-ylsulfanyl)methyl]hexanoic acid with the amino group of hydroxylamine. It a broad-spectrum matrix metalloprotease inhibitor.


heteroarene

A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2).


An  organosulfur heterocyclic compound and an oxacycle that is 1,3-oxathiane substituted by a methyl group at position 2 and a propyl group at position 4 respectively.


oxapenam

A fused-ring beta-lactam system where the beta-lactam ring is fused to a 1,3-oxazolidine ring.


epoxiconazole

A racemate composed of equimolar amounts of (2S,3R)- and (2R,3S)-epoxiconazole. A broad-spectrum fungicide for control of diseases caused by Ascomycetes, Basidiomycetes and Deuteromycetes. Epoxiconazole is moderately toxic to birds, honeybees, earthworms and most aquatic organisms.


A  ring assembly that consists of two thiophene rings connected by a single covalent bond.


(E,Z)-bastadin 19

A macrocyclic lactam with oximo amide groups having a -E,Z configuration. Isolated from the marine sponge Ianthella, it has been shown to exhibit calcium channel modulatory activity.


A quinolone that is quinolin-2(1H)-one substituted by a methyl group at position 4.


tripyrrin

A tripyrrole in which the three 1H-pyrrole rings are linked by eth-1-yl-2-ylidene groups


name: 3-phenylpropanoic acid [3-(4-cyanophenyl)-2-cyclohexyl-7-methyl-6,8-dioxo-7-isoquinolinyl] ester


formylporphyrin

A porphyrin compound substituted with one or more formyl groups.


diporphyrin

A compound containing two porphyrin rings.


(S)-BULBOCAPNINE

An aporphine alkaloid that has been isolated from Corydalis and exhibits inhibitory activity against enzymes such as tyrosine 3-monooxygenase and diamine oxidase.


lactam

Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.


name: 3-[2-hydroxyethyl-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]sulfamoyl]benzoic acid ethyl ester


dimethenamide ESA

An organosulfonic acid that is 2-oxoethanesulfonic acid substituted by a (2,4-dimethylthiophen-3-yl)(1-methoxypropan-2-yl)amino group at position 2.


dipyrrins

Compounds containing two pyrrole rings linked through a methine group (-CH=).


A beta-lactam that is azetidin-2-one substituted by an ethyl group at position 4.


A synthetic dipyrrin derived from rings A and D of bilirubin IXalpha in which C-9 carries a 2-[2-(ethoxycarbonyl)phenyl]diazenyl substituent.


VENTURAMIDE A

An eighteen-membered homodetic cyclic peptide which is isolated from Oscillatoria sp. and exhibits antimalarial activity against the W2 chloroquine-resistant strain of the malarial parasite, Plasmodium falciparum.


polypyrrane

A compound containing pyrrole rings connected by methylene units.


An epoxide that is oxirane substituted by a (4-nitrophenoxy)methyl group.


A member of the class of aminoquinolines that is quinoline substituted by methyl and 2-(4-phenylcyclohexylidene)hydrazinyl groups at positions 2 and 4, respectively. It inhibits ROS production.


A bicyclic epoxide derived from (4S)-limonene.


name: 4-[1-[2-(3,4-dimethoxyphenyl)ethyl]-3-(4-methoxyphenoxy)-4-oxo-2-azetidinyl]benzoic acid methyl ester


cyclic ether

Any ether in which the oxygen atom forms part of a ring.


imidazole antifungal agent

A compound that has significant antifungal properties whose structure contains an imidazole moiety.


The (3Z)-isomer of phycoerythrobilin.


The intermediate in the biosynthesis of vitamin B12 from uroporphyrinogen III in which three methyl groups have been introduced at positions 2, 7 and 20 of the tetrapyrrole framework and in which the carboxymethyl group at position 2 has been oxidised to form a lactone ring.


bisoxazole

Any ring assembly that is a compound with a structure based on two oxazole rings connected by a single bond.


Cinchonan or (8S)-cinchonan in which one of the hydrogens at position 9 is substituted by hydroxy.


A precorrin containing seven C-methyl groups introduced into the tetrapyrrole framework.


5,10,15-trisubstituted porphyrin

A porphyrin compound substituted at three of the four methine groups of the porphyrin ring.


An L-alanine derivative obtained by formal condensation between N-butyl-L-alaninamide and 2-thienylacetic acid.


(R)-flutriafol

A 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol that has R configuration.


name: 1-(3-cyano-7-methoxy-2-quinolinyl)-4-piperidinecarboxylic acid ethyl ester


canagliflozin

A C-glycosyl compound that is used (in its hemihydrate form) for treatment of type II diabetes via inhibition of sodium-glucose transport protein subtype 2.


superphthalocyanines

Compounds containing a superphthalocyanine skeleton.


biotripyrrin-b

A tripyrrole that is an oxidized metabolite of bilirubin, in which methyl groups are present at positions 3, 7 and 13 with a vinyl group at position 2.


name: 5-nitro-2-thiophenecarboxylic acid [2-oxo-2-(1-phenylethylamino)ethyl] ester


N-methylfluvirucin A1

A lactam that is 4-hydroxyazacyclotetradecan-2-one substituted by an ethyl group at position 11, methyl group at positions 3 and 7 and a 3,6-dideoxy-3-(methylamino)-alpha-L-talopyranosyl moiety at position 4 via a glycosyl linkage (the 3R,4S,7R,11S stereoisomer). It is isolated from the fermentation broth of Nonomuraea turkmeniaca MA7364 and exhibits anthelminthic activity.


azapropazone

A member of the class of benzotriazines that is 1,2-dihydro-1,2,4-benzotriazine bearing a dimethylamino substitutent at position 3 and a methyl substituent at position 7 and in which the nitrogens at positions 1 and 2 are both acylated by a carboxy group of propylmalonic acid.


conazole antifungal drug

Any conazole antifungal agent that has been used for the treatment of fungal infections in animals or humans.


name: 7-(4-chlorophenyl)-2-methyl-5-oxo-4-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylic acid methyl ester


Fe-coproporphyrin III

A metalloporphyrin consisting of coproporphyrin III with a central iron atom.


name: 3-(thiophen-2-ylmethylidene)-1,2-dihydrocyclopenta[b]quinoline-9-carboxylic acid [2-(butylamino)-2-oxoethyl] ester


penem

An organic heterobicyclic compound that consists of (5R)-4-thia-1-azabicyclo[3.2.0]hept-2-ene bearing a 7-keto substituent. The parent of the class of penems.


sexipyridines

Members of the class of  organonitrogen heterocyclic compound that consists of cyclic and acyclic compounds composed of six linked substituted or unsubstituted pyridine rings.


organonitrogen heterocyclic compound

Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms.


An  epoxide that is oxirane substituted by a methyl and a propyl group at positions 2 and 3 respectively. Metabolite observed in cancer metabolism.


A member of the class of quinolones that is 2-methylquinolin-4(1H)-one in which the hydrogen at position 3 is replaced by a 4-[4-(trifluoromethoxy)phenoxy]phenyl group. A potent inhibitor of Toxoplasma gondii growth.


AZOMYCIN

An imidazole that is 1H-imidazole substituted at position 2 by a nitro group.


name: (6RS)-22-hydroxy-23,24,25,26,27-pentanorvitamin D3 6,19-sulfur dioxide adduct


name: 5-amino-3-[[[1-(2-furanylmethyl)-5-oxo-3-pyrrolidinyl]-oxomethoxy]methyl]thiophene-2,4-dicarboxylic acid dimethyl ester


fosfomycin

A phosphonic acid having an (R,S)-1,2-epoxypropyl group attached to phosphorus.


The (3E)-isomer of phytochromobilin.


conazole antifungal agent

A compound that has a structure that is related to miconazole, contains an azole (imidazole or triazole) moiety, and has significant systemic antifungal properties.  They inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function.


name: 2-quinolinecarboxylic acid (4-nitrophenyl) ester


STRYCHNOGUCINE A

A  bisindole alkaloid with a strychnine substructure isolated from the roots of Strychnos icaja and has been shown to exhibit antiplasmodial activity.


name: N-propan-2-ylcarbamic acid [1-(4-methyl-2-phenyl-5-thiazolyl)ethylideneamino] ester


poly[d(G)].poly[d(C)]

A double-stranded DNA polynucleotide consisting of a strand of deoxyguanosine residues with a complementary strand of deoxycytidine residues, all residues in each strand being connected by 3'->5' phosphodiester linkages.


name: 2-[2-[[2-[[1-(2,4-dimethylphenyl)-5-tetrazolyl]thio]-1-oxoethyl]amino]-4-thiazolyl]acetic acid ethyl ester


brominated poly[d(GC)].poly[d(GC)]

A double-stranded DNA polynucleotide consisting of two complementary strands consisting of repeating units of brominated guanosine and deoxycytidine residues, all residues in each strand being connected by 3'->5' phosphodiester linkages. The sites of bromination are at C-8 of guanine and C-5 of cytosine, although not all these sites are brominated, with bromination at the guanine C-8 predominating.


metronidazole

A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.


A linear sexipyridine in which six unsubstituted pyridine units are linked by five 2:6'-linkages.


triticonazole

A racemate comprising equal amounts of (R)- and (S)-triticonazole. A seed treatment fungicide for the control of common bunt, loose smut and covered smut on barley, oats and wheat.


saquinavir

An aspartic acid derivative obtained by formal condensation of the primary amino group of (2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-ylamine with the carboxy group of N(2)(-quinolin-2-ylcarbonyl)-L-asparagine. An inhibitor of HIV-1 protease.


imetit

An imidothiocarbamic ester that consists of isothiourea in which the thiol hydrogen is substituted by a 2-(imidazol-4-yl)ethyl group. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.


A member of the class of imidazoles that is 1,3-dihydroimidazole-2-thione and its derivatives by substitution.


depdecin

A polyketide that is depudecin with a methyl hydrogen substituted with a hydroxy group.


oxamniquine

A racemate comprising equimolar amounts of (R)- and (S)-oxamniquine. An anthelmintic, it is administered orally for the treatment of schistomiasis caused by Schistosoma mansoni (but not by other Schistosoma species); intramuscular administration is no longer used as it causes severe pain at the injection site.


clavulanic acid

Antibiotic isolated from Streptomyces clavuligerus. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes.


An amino acid amide that is a carboxamide obtained by formal condensation between N-butyl-L-serinamide and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid.


pemoline

A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.


cyclic ketal

A ketal in the molecule of which the ketal carbon and one or both oxygen atoms thereon are members of a ring.


epibromohydrin

An epoxide that is oxirane substituted by a bromomethyl group at position 2.


(R)-alpha-methylhistamine

An aralkylamino compound that is histamine bearing a methyl substituent at the alpha-position (the R-enantiomer).


The epoxide formed from cholest-5-ene by formal addition of oxygen across the 5,6 double bond with beta-configuration at both C-5 and C-6.


name: 2-(4-hydroxy-2-oxo-1H-quinolin-3-yl)acetic acid propyl ester


A 1,3-thiazole that is substituted at positions 2 and 4 by isopropyl and methyl groups, respectively. A fruit flavour intensifier, it has a peach flavour with distinct vegetable and tropical notes. Also used in apricot, nectarine, durian, mango, pear and blackcurrant flavours. Present in Indonesian durian fruit (Durio zibethinus), red tomatoes, yeast extract, coriander seed oil, and roast meats.


name: 2,3-dihydro-1,4-dioxin-5-carboxylic acid [2-oxo-2-(4-phenylbutan-2-ylamino)ethyl] ester


name: 5-nitro-2-thiophenecarboxylic acid [1-[(3,5-dichloro-2-pyridinyl)amino]-1-oxopropan-2-yl] ester


imidazoles

A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton.


diazaborine derivative

Any organonitrogen heterocyclic compound that is derived from diazaborine.


pyrazinoindole

An organic heterotricyclic compound comprising a pyrazine ring fused to an indole ring system.


A  bipyridine in which the two pyridine moieties are linked by a bond between positions C-4 and C-4'.


hydroxyimidazole

Any member of the class of imidazoles in which the imidazole ring is substituted by one or more hydroxy groups.


name: 2-phenyl-4-quinolinecarboxylic acid [2-[2-chloro-5-(dimethylsulfamoyl)anilino]-2-oxoethyl] ester


tetrahydropyrimidine

Any organonitrogen heterocyclic compound containing a pyrimidine ring that has been reduced by the formal addition of 2 mol eq. of hydrogen.


corrin

A tetrapyrrole fundamental parent that is the core macrocycle of vitamin B12.


beta-lactam antibiotic allergen

Any beta-lactam antibiotic which causes the onset of an allergic reaction.


A 1,3-oxazole having a phenyl substituent at the 2-position and an oxo group at the 5-position. Note that phenyloxazolone is commonly used as a synonym for 4-(ethoxymethylene)-2-phenyloxazol-5-one (PhOx).


name: 2-(4-bromophenyl)-4-quinolinecarboxylic acid (2-oxo-3-oxolanyl) ester


name: 4-amino-3-[(cyclohexylamino)-oxomethyl]-5-isothiazolecarboxylic acid ethyl ester


name: 2-sulfanylidene-1,3-dithiole-4,5-dicarboxylic acid dimethyl ester


name: 2-(4-methoxyphenyl)-4-quinolinecarboxylic acid [2-oxo-2-(propan-2-ylamino)ethyl] ester


tolazoline

A member of the class of imidazoles that is 4,5-dihydro-1H-imidazole substituted by a benzyl group.


The second intermediate in the biosynthesis of vitamin B12 from uroporphyrinogen III, in which methyl groups have been introduced at positions 2 and 7 of the tetrapyrrole framework.


A 5-membered heterocyclic compound, which is substituted in the 2-position with a methyl group and which is often used as a monomer in polymerisation reactions.


The (3Z)-isomer of (2R)-phycocyanobilin.


bisindole

A compound containing two indole units.


4-vinylcyclohexene dioxide

The diepoxide of 4-vinylcyclohexene.


name: 2-amino-5-oxo-4-phenyl-1-[3-(trifluoromethyl)phenyl]-4,6,7,8-tetrahydroquinoline-3-carboxylic acid methyl ester


mefentrifluconazole

A racemate comprising equimolar amounts of R- and S-mefentrifluconazole.  A fungicide developed by BASF for the control of Septoria in wheat.


The (8S)-epimer of cinchonan.


imidazole fungicide

Any imidazole antifungal agent that has been used as a fungicide.


name: 2-methyl-1-cyclopropanecarboxylic acid [5-[2-(3,4-dimethoxyphenyl)-4-quinolinyl]-1,3,4-oxadiazol-2-yl]methyl ester


DIECKOL

A phlorotannin isolated from a brown alga Ecklonia cava which exhibits antioxidant, hepatoprotective and anticoagulant activities.


A member of the class of ureas obtained by formal condensation of the carboxy group of [3-tert-butyl-1-(4-methylphenyl)pyrazol-5-yl]carbamic acid with the amino group of 4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-amine.


oxacycle

Any organic heterocyclic compound containing at least one ring oxygen atom.


cis-dipyrrin

The cis-isomer of dipyrrin.


ISAVUCONAZONIUM SULFATE

An azaheterocycle sulfate salt that is a prodrug for isavuconazole, an antifungal agent used for the treatment of invasive aspergillosis and invasive mucormycosis.


poly[d(T)].poly[d(A)].poly[d(T)]

A triple-stranded DNA polynucleotide consisting of two strands of thymidine and residues, with a complementary strand of deoxyadenosine residues, all residues in each strand being connected by 3'->5' phosphodiester linkages.


benzothiadiazine

Heterocyclic compound of a ring with sulfur and two nitrogen atoms fused to a benzene ring. Members inhibit sodium-potassium-chloride symporters and are used as diuretics.


name: cyclohexanecarboxylic acid [1-(2-thiazolyl)ethylideneamino] ester


eberconazole nitrate

A racemate comprising equimolar amounts of (R)- and (S)-eberconazole nitrate. Used for topical treatment of superficial mycoses.


name: 3-[5-(4-ethylphenyl)-2-tetrazolyl]propanoic acid methyl ester


ansamycin

A class of macrocyclic lactams that consist of an aromatic (phenyl or naphthyl) or quinonoid (benzoquinone or naphthoquinone) moiety that is bridged by an aliphatic chain.


sulfamoxole

A sulfonamide antibiotic in which 4-aminobenzenesulfonic acid and 4,5-dimethyl-1,3-oxazol-2-amine have combined to form the sulfonamide bond.


FENAMIDONE

A member of the class of imidazolones that is 3,5-dihydroimidazol-4-one substituted at position 2 by a methylthiogroup, at position 3 by an anilino group and at position 5 by phenyl and methyl groups (the S-enantiomer). A fungicide effective against Oomycete diseases such as downy mildew and certain leaf spot diseases.


A phlorotanin that is 1,1'-bioxanthrene substituted by 3,5-dihydroxyphenoxy groups at position 6 and 6' and hydroxy groups at positions  2, 2', 4, 4', 7, 7', 9 and 9' respectively. It is isolated  from an edible marine brown alga Ecklonia cava and exhibits antioxidant activity.


triple-stranded DNA polynucleotide

A nucleobase-containing molecular entity with a polymeric structure comprised of three complementary DNA polynucleotide strands linked by hydrogen bonding.


platinum(II) octaethylporphyrin ketone

A platinum(II) porphyrin compound having a 2-keto group and eight ethyl substituents in the 3-, 3-, 7-, 8-, 12-, 13-, 17- and 18-positions.


crown thioether

Crown compounds containing only sulfur as coordinating atom.


phthalocyanines

Compounds containing a phthalocyanine skeleton.


BASTADIN 19

A macrocyclic lactam with oximo amide groups having a -E,E configuration. Isolated from the marine sponge Ianthella, it has been shown to exhibit calcium channel modulatory activity.


A hydrazone that is a tautomer of 8-(2-carboxyethyl)-2,7-dimethyl-3-vinyl-9-(phenyldiazenyl)dipyrrin-1(10H)-one.


name: 2-[[1-oxo-2-(1H-1,2,4-triazol-5-ylthio)ethyl]amino]-4-thiophen-2-yl-3-thiophenecarboxylic acid ethyl ester


name: 3-phenylpropanoic acid [3-(4-cyanophenyl)-7-methyl-6,8-dioxo-2-[2-(2-pyridinyl)ethyl]-7-isoquinolinyl] ester


Any tetrahydropyrimidine in which the double bond is between positions 1 and 2.


A heteroaryl hydroxy compound that is 2-quinolone substituted at position 4 by a hydroxy group.


(S)-butoconazole nitrate

The nitric acid salt of (S)-butoconazole.


A quinoline that is 1,2-dihydroquinoline bearing three methyl substituents at position 2, 2 and 4 as well as an ethoxy substituent at position 6.


trichlormethiazide

A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension.


A 1,3-thiazolium cation that is 1,3-thiazol-3-ium substituted by a methyl group at position 4, a (4-amino-2-methylpyrimidin-5-yl)methyl group at position 3, a 3-carboxy-1-hydroxypropyl at position 2 and a 2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl group at position 5.


name: 3-(1H-imidazol-5-yl)-2-propenoic acid methyl ester


HISTIDINOL

An amino alcohol that is propanol substituted by 1H-imidazol-4-yl group at position 3 and an amino group at position 2 (the 2S stereoisomer).


dorzolamide

5,6-Dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide in which hydrogens at the 4 and 6 positions are substituted by ethylamino and methyl groups, respectively (4S, trans-configuration). A carbonic anhydrase inhibitor, it is used as the hydrochloride in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.


sertaconazole nitrate

A racemate comprising equimolar amounts of (R)- and (S)-sertaconazole nitrate. A broad spectrum antifungal with added antipruritic and anti-inflammatory activity used for treatment of various skin infections.


mesoporphyrins

Any porphyrin compound produced from a protoporphyrin by the addition of a hydrogen to the double bond of each of the vinyl groups.


texaphyrin

A class of synthetic expanded porphyrins with a 22 pi-electron aromatic system. They are named after the state of Texas where these compounds were first synthesised.


tripyrrane

A compound containing three pyrrole rings connected by methylene units.


carbapenam

A beta-lactam in which the beta-lactam is fused to a pyrrolidine ring.


bacteriochlorins

Tetrahydroporphyrins in which the saturated carbon atoms are located at nonfused carbon atoms of two diagonally opposite pyrrole rings.


diazole

An azole that is either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring.


phycocyanobilin

A bilin that consists of 8,12-bis(2-carboxyethyl)-18-ethyl-3-ethylidene-2,7,13,17-tetramethyl-2,3-dihydrobilin bearing two oxo substituents at positions 1 and 19.


A crown ether that is 18-crown-6 ortho-fused to two benzene rings at positions 8-9 and 17-18.


(R)-oxamniquine

A {2-[(isopropylamino)methyl]-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl}methanol that has R configuration.


penems

An  organosulfur heterocyclic compound that contains a beta-lactam ring.


crown amine

Crown compounds containing only nitrogen as coordinating atom.


sexipyridine

A cyclic sexipyridine in which six unsubstituted pyridine units are linked by six 2:6'-linkages


gamma-lactam

A lactam in which the amide bond is contained within a five-membered ring, which includes the amide nitrogen and the carbonyl carbon.


zarzissine

A organonitrogen heterocyclic compound that is 1H-imidazo[4,5-d]pyridazine substituted by an amino group at position 2. A guanidine alkaloid isolated from Anchinoe paupertas, it exhibits cytotoxic activity against human and murine tumor cell lines.


An unsubstituted beta-lactam compound.


thermorubin

Antibiotic substance produced by Thermoactinomyces antibioticus.


fluoxytioconazole (thiol)

A racemate comprising equimolar amounts of (R)- and (S)-fluoxytioconazole (thiol). It is a conazole fungicide from Corteva Agriscience. Its mechanism of action is most likely due to the inhibition of ergosterol biosynthesis via inhibition of C14-demethylase (SBI Class I).


fluconazole

A member of the class of  triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.


oxpoconazole

A racemate comprising equimolar amounts of (R)- and (S)-oxpoconazole. Used (as its fumarate salt) to control a variety of fungal diseases including Botrytis, Sclerotinia and Monilinia spp.


5'-CTGC-3' dsDNA oligonucleotide

A double-stranded DNA fragment consisting of a 5'-CTGC-3' strand antiparallel to a 3'-GACG-5' strand.


name: 4-[oxo-(pyridin-4-ylamino)methyl]-1H-imidazole-5-carboxylic acid ethyl ester


bilane

A linear tetrapyrrole fundamental parent that consists of four pyrrole units connected via methylene linkages between positions 2 and 5.


crown ether

Crown compounds containing only oxygen as coordinating atom.


name: 2-(4-methylsulfonylphenyl)-6-imidazo[1,2-a]pyridinecarboxylic acid methyl ester


A member of the class of triazoles that is 2H-1,2,3-triazole carrying two phenyl substituents at positions 4 and 5.


beta-substituted porphyrin

A porphyrin compound which is substituted via the pyrrole groups in the porphyrin ring.


glycidyl 2,2-dinitropropyl formal

A C-nitro compound consisting of methanediol having a glycidyl group attached to one oxygen and a 2,2-dinitropropyl group attached to the other.


The (3E)-isomer of phycoerythrobilin.


biotripyrrin-a

A tripyrrole that is an oxidized metabolite of bilirubin, in which methyl groups are present at positions 2, 7 and 13 with a vinyl group at position 3.


A thiophene derivative that consists of two thiophene rings connected by a 2,2'-linkage.


strychnogucine B

A bisindole alkaloid with a strychnine substructure isolated from the roots of Strychnos icaja and has been shown to exhibit antiplasmodial activity.


THIOCYCLAM

An organosulfur heterocyclic compound that is 1,2,3-trithiane in which one of the hydrogens at position 5 has been replaced by a dimethylamino group. A nicotinic acetylcholine receptor agonist, it was used (particularly as its hydrogen oxalate salt, known as thyocyclam oxalate) as a broad-spectrum insecticide, but it is also toxic to bees, fish and other aquatic organisms. It is not approved for use within the European Union.


L-thyroxine residue

An L-alpha-amino-acid residue derived from L-thyroxine.


An oligopeptide composed of L-alanine, L-arginine, glycine, L-tyrosine, L-serine, L-serine, L-phenylalanine, L-isoleucine, L-tyrosine, L-trytophan, L-phenylalanine, L-phenylalanine, L-aspartic acid and L-phenylalanine joined in sequence by peptide linkages.


organic tetrachlorozincate salt

An organic salt containing tetrachlorozincate as the anionic component.


brilliant cresyl blue

An organic tetrachlorozincate salt having 3-amino-7-(diethylamino)-2-methylphenoxazin-5-ium as the counterion. Used for the staining of reticulocytes and platelets.


GlyTouCan G06231AO

A composition-only glycan consisting of five hexosyl groups, three acetaminohexosyl groups and three 6-deoxyhexosyl groups (identities and connectivity unknown). Composition: Hex5 HexNAc3 dHex3.


A peptidyl group derived from N-acetyl-L-methionyl-L-tryptophan.


An amino trisaccharide consisting of N-acetyl-alpha-neuraminyl, beta-D-galactosyl and 6-sulfated N-acetyl-beta-D-gluosamine residues linked sequentially (2->3) and (1->4).


A D-galactosyl-N-acylsphingosine in which the ceramide N-acyl group is specified as hexadecanoyl.


Rotaxanes consisting of a single shaft and two macrocycles.


A glycol that is triacontane bearing two hydroxy substituents located at positions 1 and 2.


Arg-His-Trp

A tripeptide composed of L-arginine, L-histidine and L-tryptophan joined in sequence by peptide linkages.


A glycodihydroceramide having an alpha-D-glucuronosyl group at the 1-position of the sphinganine skeleton and a (2R)-2-hydroxytridecanoyl group attached to the nitrogen.


cyclohexanone ring

A cyclic organic group consisting of five singly bonded carbon atoms and one carbon atom doubly bonded to an oxygen atom.


L-glutamo(2-) group

An alpha-amino-acid residue anion obtained by deprotonation of the two carboxy functions of L-glutamo group. Major structure at pH 7.3.


name: C-terminal proteinogenic amino-acid residue(1-)

description: An alpha-amino-acid residue anion obtained by deprotonation of the carboxy group of any C-terminal proteinogenic amino acid.


N(2)-L-glutamino(1-) group

An anionic amino-acid residue that is the conjugate base of N(2)-L-glutamino group, obtained by deprotonation of the carboxy group; major species at pH 7.3.


glycino(1-) group

An alpha-amino-acid residue anion obtained by deprotonation of the carboxy group of glycino group; major species at pH 7.3.


name: 2-[(2S,5R,6R)-5-[(2-fluorophenyl)sulfonylamino]-6-(hydroxymethyl)-2-oxanyl]acetic acid methyl ester


bismuth ion

A bismuth atom having a net electric charge.


A bismuth cation having a net electric charge of +3.


bismuth cation

A bismuth ion having a positive net electric charge.


CIS-ASARONE

The cis-isomer of asarone.