name: AMPK inhibits chREBP transcriptional activation activity (Homo sapiens)


name: Phosphorylation of ChREBP at Serine 556 by AMPK (Homo sapiens)

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: LKB1 phosphorylates the alpha subunit of AMPK heterotrimer (Homo sapiens)


name: AMP binds to gamma subunit of AMP kinase heterotrimer (Homo sapiens)


name: ADIPOQ trimer binds ADIPOR dimers (Homo sapiens)


name: AMPK inhibits chREBP transcriptional activation activity (Mus musculus)

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: AMP binds to gamma subunit of AMP kinase heterotrimer (Mus musculus)


name: ADIPOQ trimer binds ADIPOR dimers (Mus musculus)


name: AMPK inhibits chREBP transcriptional activation activity (Rattus norvegicus)


name: ADIPOQ trimer binds ADIPOR dimers (Rattus norvegicus)


name: AMP binds to gamma subunit of AMP kinase heterotrimer (Rattus norvegicus)


name: AMPK inhibits chREBP transcriptional activation activity (Canis familiaris)


name: AMP binds to gamma subunit of AMP kinase heterotrimer (Canis familiaris)


name: ADIPOQ trimer binds ADIPOR dimers (Canis familiaris)


name: AMPK inhibits chREBP transcriptional activation activity (Bos taurus)


name: AMP binds to gamma subunit of AMP kinase heterotrimer (Bos taurus)


name: ADIPOQ trimer binds ADIPOR dimers (Bos taurus)


name: AMPK inhibits chREBP transcriptional activation activity (Sus scrofa)


name: ADIPOQ trimer binds ADIPOR dimers (Sus scrofa)


name: AMP binds to gamma subunit of AMP kinase heterotrimer (Sus scrofa)


name: AMPK inhibits chREBP transcriptional activation activity (Danio rerio)


name: ADIPOQ trimer binds ADIPOR dimers (Danio rerio)


name: AMPK inhibits chREBP transcriptional activation activity (Drosophila melanogaster)


name: AMP binds to gamma subunit of AMP kinase heterotrimer (Drosophila melanogaster)


name: AMPK inhibits chREBP transcriptional activation activity (Caenorhabditis elegans)


name: AMP binds to gamma subunit of AMP kinase heterotrimer (Caenorhabditis elegans)


name: AMPK inhibits chREBP transcriptional activation activity (Dictyostelium discoideum)


name: AMP binds to gamma subunit of AMP kinase heterotrimer (Dictyostelium discoideum)


name: AMPK inhibits chREBP transcriptional activation activity (Schizosaccharomyces pombe)


name: AMP binds to gamma subunit of AMP kinase heterotrimer (Schizosaccharomyces pombe)


name: AMPK inhibits chREBP transcriptional activation activity (Saccharomyces cerevisiae)


name: AMP binds to gamma subunit of AMP kinase heterotrimer (Saccharomyces cerevisiae)


name: PP2A-mediated dephosphorylation of key metabolic factors (Homo sapiens)


name: Dephosphorylation of pChREBP (Ser 196) by PP2A (Homo sapiens)


name: Dephosphorylation of pChREBP (Thr 666) by PP2A (Homo sapiens)


name: Dephosphorylation of pChREBP (Ser 556) by PP2A (Homo sapiens)


name: ChREBP activates metabolic gene expression (Homo sapiens)


name: Transcriptional activation of ACACA by ChREBP:MLX (Homo sapiens)


name: Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX (Homo sapiens)


name: Transcriptional activation of FASN monomer gene by ChREBP:MLX (Homo sapiens)


name: Transcriptional activation of PKLR gene by ChREBP:MLX (Homo sapiens)


name: MLXIPL:MLX binds FASN gene promoter (Homo sapiens)


name: MLXIPL:MLX binds ACLY gene promoter (Homo sapiens)


name: MLXIPL:MLX binds ACACB gene promoter (Homo sapiens)


name: MLXIPL:MLX binds ACACA gene promoter (Homo sapiens)


name: Formation of ChREBP:MLX heterodimer (Homo sapiens)


name: MLXIPL:MLX binds PKLR gene promoter (Homo sapiens)


name: Transcriptional activation of ACACB by ChREBP:MLX (Homo sapiens)


name: MLXIPL:MLX binds AGPAT1 gene promoter (Homo sapiens)


name: Transcriptional activation of AGPAT1 by ChREBP:MLX (Homo sapiens)


name: Insulin effects increased synthesis of Xylulose-5-Phosphate (Homo sapiens)


name: Insulin effects increased synthesis of Xylulose-5-Phosphate (Mus musculus)


name: Insulin effects increased synthesis of Xylulose-5-Phosphate (Rattus norvegicus)


name: Insulin effects increased synthesis of Xylulose-5-Phosphate (Canis familiaris)


name: Insulin effects increased synthesis of Xylulose-5-Phosphate (Bos taurus)


name: Insulin effects increased synthesis of Xylulose-5-Phosphate (Sus scrofa)


name: Insulin effects increased synthesis of Xylulose-5-Phosphate (Danio rerio)


name: Insulin effects increased synthesis of Xylulose-5-Phosphate (Xenopus tropicalis)


name: Insulin effects increased synthesis of Xylulose-5-Phosphate (Drosophila melanogaster)


name: Insulin effects increased synthesis of Xylulose-5-Phosphate (Caenorhabditis elegans)


name: Insulin effects increased synthesis of Xylulose-5-Phosphate (Dictyostelium discoideum)


name: Insulin effects increased synthesis of Xylulose-5-Phosphate (Schizosaccharomyces pombe)


name: Insulin effects increased synthesis of Xylulose-5-Phosphate (Saccharomyces cerevisiae)


name: PKA-mediated phosphorylation of key metabolic factors (Homo sapiens)


name: Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA (Homo sapiens)


name: Phosphorylation of ChREBP at Thr(653) by PKA (Homo sapiens)


name: PhosphoChREBP (Thr 653) is exported to cytosol (Homo sapiens)


name: Nuclear transport of pChREBP (Thr 666) protein (Homo sapiens)


name: PKA-mediated phosphorylation of key metabolic factors (Rattus norvegicus)


name: PhosphoChREBP (Thr 653) is exported to cytosol (Rattus norvegicus)


name: Nuclear transport of pChREBP (Thr 666) protein (Rattus norvegicus)


name: PKA-mediated phosphorylation of key metabolic factors (Canis familiaris)


name: PhosphoChREBP (Thr 653) is exported to cytosol (Canis familiaris)


name: Nuclear transport of pChREBP (Thr 666) protein (Canis familiaris)


name: PKA-mediated phosphorylation of key metabolic factors (Sus scrofa)


name: Nuclear transport of pChREBP (Thr 666) protein (Sus scrofa)


name: PhosphoChREBP (Thr 653) is exported to cytosol (Sus scrofa)


name: PKA-mediated phosphorylation of key metabolic factors (Drosophila melanogaster)


name: Nuclear transport of pChREBP (Thr 666) protein (Drosophila melanogaster)


name: PhosphoChREBP (Thr 653) is exported to cytosol (Drosophila melanogaster)


name: PKA-mediated phosphorylation of key metabolic factors (Caenorhabditis elegans)


name: PhosphoChREBP (Thr 653) is exported to cytosol (Caenorhabditis elegans)


name: Nuclear transport of pChREBP (Thr 666) protein (Caenorhabditis elegans)


name: Glucagon signaling in metabolic regulation (Homo sapiens)


name: Glucagon binds to Glucagon receptor (Homo sapiens)


name: Glucagon:GCGR mediates GTP-GDP exchange (Homo sapiens)


name: PKA activation in glucagon signalling (Homo sapiens)


name: PKA activation in glucagon signalling (Mus musculus)


name: PKA activation in glucagon signalling (Rattus norvegicus)


name: PKA activation in glucagon signalling (Canis familiaris)


name: PKA activation in glucagon signalling (Bos taurus)


name: PKA activation in glucagon signalling (Sus scrofa)


name: PKA activation in glucagon signalling (Danio rerio)


name: PKA activation in glucagon signalling (Xenopus tropicalis)


name: PKA activation in glucagon signalling (Drosophila melanogaster)


name: PKA activation in glucagon signalling (Caenorhabditis elegans)


name: PKA activation in glucagon signalling (Schizosaccharomyces pombe)


name: PKA activation in glucagon signalling (Saccharomyces cerevisiae)


name: Glucagon signaling in metabolic regulation (Mus musculus)


name: Glucagon binds to Glucagon receptor (Mus musculus)


name: Glucagon signaling in metabolic regulation (Rattus norvegicus)


name: Glucagon binds to Glucagon receptor (Rattus norvegicus)


name: Glucagon signaling in metabolic regulation (Canis familiaris)


name: Glucagon binds to Glucagon receptor (Canis familiaris)


name: Glucagon signaling in metabolic regulation (Bos taurus)


name: Glucagon binds to Glucagon receptor (Bos taurus)


name: Glucagon signaling in metabolic regulation (Sus scrofa)


name: Glucagon binds to Glucagon receptor (Sus scrofa)


name: Glucagon signaling in metabolic regulation (Xenopus tropicalis)


name: Glucagon binds to Glucagon receptor (Xenopus tropicalis)


name: Glucagon binds to Glucagon receptor (Gallus gallus)


name: Defective SLC6A19 causes Hartnup disorder (HND) (Homo sapiens)


name: Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)


name: Defective SLC7A9 causes cystinuria (CSNU) (Homo sapiens)


name: Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)


name: Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria (Homo sapiens)


name: Defective SLC6A18 does not transport Gly from extracellular region to cytosol (Homo sapiens)


name: Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) (Homo sapiens)


name: Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP (Homo sapiens)


name: Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) (Homo sapiens)


name: Defective SLC24A5 does not exchange cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Homo sapiens)


name: Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) (Homo sapiens)


name: Defective SLC12A6 does not cotransport K+, Cl- from cytosol to extracellular region (Homo sapiens)


name: Defective SLC17A5 causes Salla disease (SD) and ISSD (Homo sapiens)


name: Defective SLC17A5 does not cotransport Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)


name: Defective SLC33A1 causes spastic paraplegia 42 (SPG42) (Homo sapiens)


name: Defective SLC33A1 does not transport Ac-CoA from cytosol to Golgi lumen (Homo sapiens)


name: Defective CP causes aceruloplasminemia (ACERULOP) (Homo sapiens)


name: Defective CP does not oxidise Fe2+ to Fe3+ (Homo sapiens)


name: Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) (Homo sapiens)


name: Defective SLC40A1 does not transport Fe3+ from extracellular region to cytosol (Homo sapiens)


name: Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) (Homo sapiens)


name: Defective SLC29A3 does not transport nucleosides from lysosomal lumen to cytosol (Homo sapiens)


name: Defective SLC1A3 causes episodic ataxia 6 (EA6) (Homo sapiens)


name: Defective SLC1A3 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)


name: Defective HK1 causes hexokinase deficiency (HK deficiency) (Homo sapiens)


name: Defective HK1 does not phosphorylate Glc to form G6P (Homo sapiens)


name: Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) (Homo sapiens)


name: Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)


name: Defective SLC2A10 causes arterial tortuosity syndrome (ATS) (Homo sapiens)


name: Defective SLC2A10 does not transport Glc from extracellular region to cytosol (Homo sapiens)


name: Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) (Homo sapiens)


name: Defective SLC22A12 does not exchange extracellular urate for cytosolic LACT (Homo sapiens)


name: Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) (Homo sapiens)


name: Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)


name: Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) (Homo sapiens)


name: SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)


name: Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) (Homo sapiens)


name: Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+ (Homo sapiens)


name: Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) (Homo sapiens)


name: Defective SLC34A2 does not cotransport Pi, 3Na+ (Homo sapiens)


name: Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) (Homo sapiens)


name: Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)


name: Defective SLC6A19 causes Hartnup disorder (HND) (Homo sapiens)


name: Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) (Homo sapiens)


name: Defective SLC2A9 does not transport Fru, Glc, urate (Homo sapiens)


name: Defective SLC26A4 causes Pendred syndrome (PDS) (Homo sapiens)


name: SLC26A4 does not transport I- from cytosol to extracellular region (Homo sapiens)


name: Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) (Homo sapiens)


name: Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)


name: Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) (Homo sapiens)


name: Defective AVP mutants do not bind AVPR2 (Homo sapiens)


name: Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) (Homo sapiens)


name: Defective SLC34A1 does not cotransport Pi, 3Na+ (Homo sapiens)


name: Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) (Homo sapiens)


name: SLC2A1 tetramer does not transport Glc from extracellular region to cytosol (Homo sapiens)


name: Defective SLC5A2 causes renal glucosuria (GLYS1) (Homo sapiens)


name: Defective SLC5A2 does not cotransport Glc and Na+ from extracellular region to cytosol (Homo sapiens)


name: Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) (Homo sapiens)


name: Defective RHAG does not transport NH4+ from cytosol to extracellular region (rbc) (Homo sapiens)


name: Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) (Homo sapiens)


name: Defective SLC22A5 does not cotransport CAR, Na+ from extracellular region to cytosol (Homo sapiens)


name: Defective SLC9A9 causes autism 16 (AUTS16) (Homo sapiens)


name: Defective SLC9A9 does not exchange Na+ for H+ across the late endosome membrane (Homo sapiens)


name: Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) (Homo sapiens)


name: Defective SLC24A4 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)


name: Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) (Homo sapiens)


name: Defective SLC4A4 does not cotransport Na+ with 3HCO3- (Homo sapiens)


name: Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) (Homo sapiens)


name: Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region (Homo sapiens)


name: Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) (Homo sapiens)


name: Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol (Homo sapiens)


name: Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4),  distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) (Homo sapiens)


name: Defective SLC4A1 does not exchange Cl- for HCO3- (in erythrocytes) (Homo sapiens)


name: Defective SLC9A6 causes  X-linked, syndromic mental retardation,, Christianson type (MRXSCH) (Homo sapiens)


name: Defective SLC9A6 does not exchange Na+ for H+ across the early endosome membrane (Homo sapiens)


name: Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) (Homo sapiens)


name: Defective SLCO2A1 does not transport PGT substrates from extracellular region to cytosol (Homo sapiens)


name: Variant SLC6A14 may confer susceptibility towards obesity (Homo sapiens)


name: Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)


name: Defective SLC6A5 causes hyperekplexia 3 (HKPX3) (Homo sapiens)


name: Defective SLC6A5 does not cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)


name: Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) (Homo sapiens)


name: Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol (Homo sapiens)


name: Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) (Homo sapiens)


name: Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol (Homo sapiens)


name: Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) (Homo sapiens)


name: Defective SLC34A3 does not cotransport Pi, 2Na+ (Homo sapiens)


name: Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) (Homo sapiens)


name: Defective SLC5A5 does not cotransport Na+ with I- from extracellular region to cytosol (Homo sapiens)


name: Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) (Homo sapiens)


name: Defective AVP mutants do not bind AVPR1A,B (Homo sapiens)


name: Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) (Homo sapiens)


name: Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)


name: Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) (Homo sapiens)


name: Defective SLC24A1 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)


name: Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) (Homo sapiens)


name: Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)


name: Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria (Homo sapiens)


name: Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) (Homo sapiens)


name: Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen (Homo sapiens)


name: Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) (Homo sapiens)


name: Defective GCK does not phosphorylate Glc to form G6P (Homo sapiens)


name: Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) (Homo sapiens)


name: Defective SLC35A2 does not exchange UDP-Gal, UDP-GalNAc for UMP (Homo sapiens)


name: Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) (Homo sapiens)


name: SLC26A3 does not exchange Cl- for HCO3- (Homo sapiens)


name: Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) (Homo sapiens)


name: Defective SLC12A3 causes Gitelman syndrome (GS) (Homo sapiens)


name: Defective SLC12A3 does not cotransport Cl-, Na+ from extracellular region to cytosol (Homo sapiens)


name: Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) (Homo sapiens)


name: Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol (Homo sapiens)


name: Neurotransmitter clearance (Homo sapiens)


name: Noradrenaline clearance from the synaptic cleft (Homo sapiens)


name: AcCho is hydrolyzed to Cho and acetate by ACHE (Homo sapiens)


name: Serotonin clearance from the synaptic cleft (Homo sapiens)


name: SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)


name: SLC6A4 binds TCAs and SSRIs (Homo sapiens)


name: 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Homo sapiens)


name: 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Mus musculus)


name: Metabolism of serotonin (Rattus norvegicus)


name: 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Rattus norvegicus)


name: Metabolism of serotonin (Canis familiaris)


name: 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Canis familiaris)


name: 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Bos taurus)


name: 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Sus scrofa)


name: 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Danio rerio)


name: Metabolism of serotonin (Xenopus tropicalis)


name: 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Xenopus tropicalis)


name: 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Gallus gallus)


name: Metabolism of serotonin (Drosophila melanogaster)


name: 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Drosophila melanogaster)


name: Metabolism of serotonin (Caenorhabditis elegans)


name: 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Caenorhabditis elegans)


name: Metabolism of serotonin (Dictyostelium discoideum)


name: 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Dictyostelium discoideum)


name: Metabolism of serotonin (Schizosaccharomyces pombe)


name: 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Schizosaccharomyces pombe)


name: Metabolism of serotonin (Saccharomyces cerevisiae)


name: 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Saccharomyces cerevisiae)


name: Serotonin clearance from the synaptic cleft (Mus musculus)


name: SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Mus musculus)


name: SLC6A4 binds TCAs and SSRIs (Mus musculus)


name: Serotonin clearance from the synaptic cleft (Rattus norvegicus)


name: SLC6A4 binds TCAs and SSRIs (Rattus norvegicus)


name: SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)


name: Serotonin clearance from the synaptic cleft (Canis familiaris)


name: SLC6A4 binds TCAs and SSRIs (Canis familiaris)


name: SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)


name: Serotonin clearance from the synaptic cleft (Bos taurus)


name: SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Bos taurus)


name: SLC6A4 binds TCAs and SSRIs (Bos taurus)


name: Serotonin clearance from the synaptic cleft (Sus scrofa)


name: SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)


name: SLC6A4 binds TCAs and SSRIs (Sus scrofa)


name: Serotonin clearance from the synaptic cleft (Danio rerio)


name: SLC6A4 binds TCAs and SSRIs (Danio rerio)


name: SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Danio rerio)


name: Serotonin clearance from the synaptic cleft (Xenopus tropicalis)


name: SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)


name: SLC6A4 binds TCAs and SSRIs (Xenopus tropicalis)


name: Serotonin clearance from the synaptic cleft (Gallus gallus)


name: SLC6A4 binds TCAs and SSRIs (Gallus gallus)


name: SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)


name: Serotonin clearance from the synaptic cleft (Drosophila melanogaster)


name: SLC6A4 binds TCAs and SSRIs (Drosophila melanogaster)


name: SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)


name: Serotonin clearance from the synaptic cleft (Caenorhabditis elegans)


name: SLC6A4 binds TCAs and SSRIs (Caenorhabditis elegans)


name: SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)


name: Serotonin clearance from the synaptic cleft (Plasmodium falciparum)


name: SLC6A4 binds TCAs and SSRIs (Plasmodium falciparum)


name: SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Plasmodium falciparum)


name: Dopamine clearance from the synaptic cleft (Homo sapiens)


name: Enzymatic degradation of dopamine by COMT (Homo sapiens)


name: COMT transfers Met to DA to form 3MT (Homo sapiens)


name: LRTOMT transfers Met to DA, forming 3MT (Homo sapiens)


name: MAOA:FAD deaminates 3MT to HVA (Homo sapiens)


name: Enzymatic degradation of dopamine by COMT (Mus musculus)


name: COMT transfers Met to DA to form 3MT (Mus musculus)


name: LRTOMT transfers Met to DA, forming 3MT (Mus musculus)


name: MAOA:FAD deaminates 3MT to HVA (Mus musculus)


name: COMT binds COMT Inhibitors (Mus musculus)


name: Enzymatic degradation of dopamine by COMT (Rattus norvegicus)


name: COMT transfers Met to DA to form 3MT (Rattus norvegicus)


name: MAOA:FAD deaminates 3MT to HVA (Rattus norvegicus)


name: LRTOMT transfers Met to DA, forming 3MT (Rattus norvegicus)


name: COMT binds COMT Inhibitors (Rattus norvegicus)


name: Enzymatic degradation of dopamine by COMT (Canis familiaris)


name: LRTOMT transfers Met to DA, forming 3MT (Canis familiaris)


name: COMT binds COMT Inhibitors (Canis familiaris)


name: COMT transfers Met to DA to form 3MT (Canis familiaris)


name: MAOA:FAD deaminates 3MT to HVA (Canis familiaris)


name: Enzymatic degradation of dopamine by COMT (Bos taurus)


name: LRTOMT transfers Met to DA, forming 3MT (Bos taurus)


name: MAOA:FAD deaminates 3MT to HVA (Bos taurus)


name: COMT transfers Met to DA to form 3MT (Bos taurus)


name: Enzymatic degradation of dopamine by COMT (Sus scrofa)


name: MAOA:FAD deaminates 3MT to HVA (Sus scrofa)


name: COMT transfers Met to DA to form 3MT (Sus scrofa)


name: LRTOMT transfers Met to DA, forming 3MT (Sus scrofa)


name: Enzymatic degradation of dopamine by COMT (Danio rerio)


name: LRTOMT transfers Met to DA, forming 3MT (Danio rerio)


name: COMT transfers Met to DA to form 3MT (Danio rerio)


name: COMT binds COMT Inhibitors (Danio rerio)


name: Enzymatic degradation of dopamine by COMT (Xenopus tropicalis)


name: COMT transfers Met to DA to form 3MT (Xenopus tropicalis)


name: COMT binds COMT Inhibitors (Xenopus tropicalis)


name: Enzymatic degradation of dopamine by COMT (Gallus gallus)


name: COMT binds COMT Inhibitors (Gallus gallus)


name: COMT transfers Met to DA to form 3MT (Gallus gallus)


name: LRTOMT transfers Met to DA, forming 3MT (Gallus gallus)


name: MAOA:FAD deaminates 3MT to HVA (Gallus gallus)


name: Enzymatic degradation of dopamine by COMT (Dictyostelium discoideum)


name: MAOA:FAD deaminates 3MT to HVA (Dictyostelium discoideum)


name: Enzymatic degradation of dopamine by COMT (Schizosaccharomyces pombe)


name: LRTOMT transfers Met to DA, forming 3MT (Schizosaccharomyces pombe)


name: COMT binds COMT Inhibitors (Schizosaccharomyces pombe)


name: COMT transfers Met to DA to form 3MT (Schizosaccharomyces pombe)


name: Enzymatic degradation of Dopamine by monoamine oxidase (Homo sapiens)


name: COMT transfers Met to DOPAC to form HVA (Homo sapiens)


name: MAOA:FAD deaminates DA to DOPAC (Homo sapiens)


name: Enzymatic degradation of Dopamine by monoamine oxidase (Mus musculus)


name: MAOA:FAD deaminates DA to DOPAC (Mus musculus)


name: COMT transfers Met to DOPAC to form HVA (Mus musculus)


name: Enzymatic degradation of Dopamine by monoamine oxidase (Rattus norvegicus)


name: MAOA:FAD deaminates DA to DOPAC (Rattus norvegicus)


name: COMT transfers Met to DOPAC to form HVA (Rattus norvegicus)


name: Enzymatic degradation of Dopamine by monoamine oxidase (Canis familiaris)


name: COMT transfers Met to DOPAC to form HVA (Canis familiaris)


name: MAOA:FAD deaminates DA to DOPAC (Canis familiaris)


name: Enzymatic degradation of Dopamine by monoamine oxidase (Bos taurus)


name: COMT transfers Met to DOPAC to form HVA (Bos taurus)


name: MAOA:FAD deaminates DA to DOPAC (Bos taurus)


name: Enzymatic degradation of Dopamine by monoamine oxidase (Sus scrofa)


name: COMT transfers Met to DOPAC to form HVA (Sus scrofa)


name: MAOA:FAD deaminates DA to DOPAC (Sus scrofa)


name: Enzymatic degradation of Dopamine by monoamine oxidase (Danio rerio)


name: COMT transfers Met to DOPAC to form HVA (Danio rerio)


name: Enzymatic degradation of Dopamine by monoamine oxidase (Xenopus tropicalis)


name: COMT transfers Met to DOPAC to form HVA (Xenopus tropicalis)


name: Enzymatic degradation of Dopamine by monoamine oxidase (Gallus gallus)


name: MAOA:FAD deaminates DA to DOPAC (Gallus gallus)


name: COMT transfers Met to DOPAC to form HVA (Gallus gallus)


name: Enzymatic degradation of Dopamine by monoamine oxidase (Dictyostelium discoideum)


name: MAOA:FAD deaminates DA to DOPAC (Dictyostelium discoideum)


name: Enzymatic degradation of Dopamine by monoamine oxidase (Schizosaccharomyces pombe)


name: COMT transfers Met to DOPAC to form HVA (Schizosaccharomyces pombe)


name: Dopamine clearance from the synaptic cleft (Mus musculus)


name: Dopamine clearance from the synaptic cleft (Rattus norvegicus)


name: Dopamine clearance from the synaptic cleft (Canis familiaris)


name: Dopamine clearance from the synaptic cleft (Bos taurus)


name: Dopamine clearance from the synaptic cleft (Sus scrofa)


name: Dopamine clearance from the synaptic cleft (Danio rerio)


name: Dopamine clearance from the synaptic cleft (Xenopus tropicalis)


name: Dopamine clearance from the synaptic cleft (Gallus gallus)


name: Dopamine clearance from the synaptic cleft (Drosophila melanogaster)


name: SLC6A3 binds DRIs (Drosophila melanogaster)


name: Dopamine clearance from the synaptic cleft (Caenorhabditis elegans)


name: SLC6A3 binds DRIs (Caenorhabditis elegans)


name: Dopamine clearance from the synaptic cleft (Dictyostelium discoideum)


name: Dopamine clearance from the synaptic cleft (Plasmodium falciparum)


name: SLC6A3 binds DRIs (Plasmodium falciparum)


name: Neurotransmitter clearance (Mus musculus)


name: Noradrenaline clearance from the synaptic cleft (Mus musculus)


name: Neurotransmitter clearance (Rattus norvegicus)


name: Noradrenaline clearance from the synaptic cleft (Rattus norvegicus)


name: Neurotransmitter clearance (Canis familiaris)


name: Noradrenaline clearance from the synaptic cleft (Canis familiaris)


name: Noradrenaline clearance from the synaptic cleft (Bos taurus)


name: Noradrenaline clearance from the synaptic cleft (Sus scrofa)


name: AcCho is hydrolyzed to Cho and acetate by ACHE (Sus scrofa)


name: Neurotransmitter clearance (Danio rerio)


name: Noradrenaline clearance from the synaptic cleft (Danio rerio)


name: AcCho is hydrolyzed to Cho and acetate by ACHE (Danio rerio)


name: Neurotransmitter clearance (Xenopus tropicalis)


name: Noradrenaline clearance from the synaptic cleft (Xenopus tropicalis)


name: AcCho is hydrolyzed to Cho and acetate by ACHE (Xenopus tropicalis)


name: Neurotransmitter clearance (Gallus gallus)


name: Noradrenaline clearance from the synaptic cleft (Gallus gallus)


name: AcCho is hydrolyzed to Cho and acetate by ACHE (Gallus gallus)


name: Neurotransmitter clearance (Drosophila melanogaster)


name: AcCho is hydrolyzed to Cho and acetate by ACHE (Drosophila melanogaster)


name: ACHEIs bind ACHE (Drosophila melanogaster)


name: Noradrenaline clearance from the synaptic cleft (Drosophila melanogaster)


name: Neurotransmitter clearance (Caenorhabditis elegans)


name: ACHEIs bind ACHE (Caenorhabditis elegans)


name: Noradrenaline clearance from the synaptic cleft (Caenorhabditis elegans)


name: AcCho is hydrolyzed to Cho and acetate by ACHE (Caenorhabditis elegans)


name: Neurotransmitter clearance (Dictyostelium discoideum)


name: ACHEIs bind ACHE (Dictyostelium discoideum)


name: AcCho is hydrolyzed to Cho and acetate by ACHE (Dictyostelium discoideum)


name: Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) (Homo sapiens)


name: Defective SLC35A3 does not exchange UDP-GlcNAc for UMP (Homo sapiens)


name: Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) (Homo sapiens)


name: Defective SLC7A7 causes lysinuric protein intolerance (LPI) (Homo sapiens)


name: Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)


name: Defective SLC6A2 causes orthostatic intolerance (OI) (Homo sapiens)


name: Defective SLC6A2 does not cotransport NAd, Na+ from extracellular region to cytosol (Homo sapiens)


name: Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) (Homo sapiens)


name: Defective SLC27A4 does not transport LCFAs from extracellular region to cytosol (Homo sapiens)


name: Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) (Homo sapiens)


name: Defective SLC20A2 does not cotransport Pi, Na+ from extracellular region to cytosol (Homo sapiens)


name: Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) (Homo sapiens)


name: Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)


name: Defective SLC12A1 causes Bartter syndrome 1 (BS1) (Homo sapiens)


name: Defective SLC12A1 does not cotransport Na+, K+, 2Cl- from extracellular region to cytosol (Homo sapiens)


name: Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) (Homo sapiens)


name: Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)


name: Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) (Homo sapiens)


name: Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM) (Homo sapiens)


name: Defective SLC5A1 does not cotransport Glc and Na+ (Homo sapiens)


name: Defective SLC3A1 causes cystinuria (CSNU) (Homo sapiens)


name: Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)


name: Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) (Homo sapiens)


name: Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects (Homo sapiens)


name: p14ARF mutant does not translocate to the nucleus (Homo sapiens)


name: Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 (Homo sapiens)


name: p16INK4A mutants do not bind CDK4 (Homo sapiens)


name: Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 (Homo sapiens)


name: p16INK4A mutants do not bind CDK4,CDK6 (Homo sapiens)


name: Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 (Homo sapiens)


name: Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 (Homo sapiens)


name: Evasion of Oncogene Induced Senescence Due to p14ARF Defects (Homo sapiens)


name: IkBA variant leads to EDA-ID (Homo sapiens)


name: NFKBIA variant binds NFkB complex (Homo sapiens)


name: NFKBIA variant is not phosphorylated within IkBA:NF-kappaB (Homo sapiens)


name: TICAM1 deficiency blocks TLR3 pathway (Homo sapiens)


name: IRAK4 deficiency (TLR2/4) (Homo sapiens)


name: Defective IRAK4 does not bind MyD88 within the TLR2/4 complex (Homo sapiens)


name: Defective IRAK4 variants do not bind MyD88:MAL:BTK:activated TLR2/4 (Homo sapiens)


name: IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) (Homo sapiens)


name: Defective IKBKG (NEMO) destabilizes the association of IKBKA:IKBKB:IKBKG (via TLR) (Homo sapiens)


name: MyD88 deficiency (TLR2/4) (Homo sapiens)


name: Defective MyD88 does not bind MAL(TIRAP):TLR2/4 (Homo sapiens)


name: Defective MyD88 does not oligomerize within the activated TLR2/4 complex (Homo sapiens)


name: IRAK4 deficiency blocks formation of the MyD88-IRAK4 Myddosome in the TLR5 pathway (Homo sapiens)


name: Defective IRAK4 does not form a complex with MyD88 within the TLR5 complex (Homo sapiens)


name: IKBKB deficiency causes SCID (Homo sapiens)


name: Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG (Homo sapiens)


name: Defective UNC93B1 does not bind TLR3 (Homo sapiens)


name: Defective MyD88 does not oligomerize within the complex of activated TLR5 (Homo sapiens)


name: Defective regulation of TLR7 by endogenous ligand (Homo sapiens)


name: G or G analog binds C-ter TLR7 GoF variant  (Homo sapiens)


name: Defective TRAF3 does not transmit the signal (Homo sapiens)


name: Defective TLR3 does not bind viral dsRNA (Homo sapiens)


name: Translesion synthesis by POLK (Homo sapiens)


name: POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Homo sapiens)


name: POLK and POLZ cooperate in elongation of mispaired primer termini (Homo sapiens)


name: POLK incorporates dNMP opposite to damaged DNA base (Homo sapiens)


name: Translesion synthesis by POLK (Mus musculus)


name: POLK incorporates dNMP opposite to damaged DNA base (Mus musculus)


name: POLK and POLZ cooperate in elongation of mispaired primer termini (Mus musculus)


name: POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Mus musculus)


name: Translesion synthesis by POLK (Rattus norvegicus)


name: POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Rattus norvegicus)


name: POLK and POLZ cooperate in elongation of mispaired primer termini (Rattus norvegicus)


name: POLK incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)


name: Translesion synthesis by POLK (Canis familiaris)


name: POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Canis familiaris)


name: POLK incorporates dNMP opposite to damaged DNA base (Canis familiaris)


name: POLK and POLZ cooperate in elongation of mispaired primer termini (Canis familiaris)


name: Translesion synthesis by POLK (Bos taurus)


name: POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Bos taurus)


name: POLK and POLZ cooperate in elongation of mispaired primer termini (Bos taurus)


name: POLK incorporates dNMP opposite to damaged DNA base (Bos taurus)


name: Translesion synthesis by POLK (Sus scrofa)


name: POLK and POLZ cooperate in elongation of mispaired primer termini (Sus scrofa)


name: POLK incorporates dNMP opposite to damaged DNA base (Sus scrofa)


name: POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Sus scrofa)


name: Translesion synthesis by POLK (Xenopus tropicalis)


name: POLK incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)


name: POLK and POLZ cooperate in elongation of mispaired primer termini (Xenopus tropicalis)


name: Translesion synthesis by POLK (Gallus gallus)


name: POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Gallus gallus)


name: POLK and POLZ cooperate in elongation of mispaired primer termini (Gallus gallus)


name: POLK incorporates dNMP opposite to damaged DNA base (Gallus gallus)


name: Translesion synthesis by POLK (Drosophila melanogaster)


name: POLK and POLZ cooperate in elongation of mispaired primer termini (Drosophila melanogaster)


name: POLK incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)


name: Translesion synthesis by POLK (Caenorhabditis elegans)


name: POLK incorporates dNMP opposite to damaged DNA base (Caenorhabditis elegans)


name: Translesion synthesis by POLK (Dictyostelium discoideum)


name: POLK incorporates dNMP opposite to damaged DNA base (Dictyostelium discoideum)


name: Translesion synthesis by POLK (Schizosaccharomyces pombe)


name: POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Schizosaccharomyces pombe)


name: POLK and POLZ cooperate in elongation of mispaired primer termini (Schizosaccharomyces pombe)


name: POLK incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)


name: Translesion synthesis by POLK (Saccharomyces cerevisiae)


name: POLK incorporates dNMP opposite to damaged DNA base (Saccharomyces cerevisiae)


name: POLK and POLZ cooperate in elongation of mispaired primer termini (Saccharomyces cerevisiae)


name: Translesion synthesis by POLK (Plasmodium falciparum)


name: POLK and POLZ cooperate in elongation of mispaired primer termini (Plasmodium falciparum)


name: POLK incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)


name: Translesion Synthesis by POLH (Homo sapiens)


name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Homo sapiens)


name: POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Homo sapiens)


name: SPRTN binds monoUb:K164-PCNA associated with POLH (Homo sapiens)


name: Insertion of correct bases opposite the lesion by POLH (Homo sapiens)


name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Homo sapiens)


name: RCHY1 monoubiquitinates POLH (Homo sapiens)


name: Translesion Synthesis by POLH (Mus musculus)


name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Mus musculus)


name: RCHY1 monoubiquitinates POLH (Mus musculus)


name: Insertion of correct bases opposite the lesion by POLH (Mus musculus)


name: SPRTN binds monoUb:K164-PCNA associated with POLH (Mus musculus)


name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Mus musculus)


name: POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Mus musculus)


name: Translesion Synthesis by POLH (Rattus norvegicus)


name: POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Rattus norvegicus)


name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Rattus norvegicus)


name: SPRTN binds monoUb:K164-PCNA associated with POLH (Rattus norvegicus)


name: Insertion of correct bases opposite the lesion by POLH (Rattus norvegicus)


name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Rattus norvegicus)


name: RCHY1 monoubiquitinates POLH (Rattus norvegicus)


name: Translesion Synthesis by POLH (Canis familiaris)


name: Insertion of correct bases opposite the lesion by POLH (Canis familiaris)


name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Canis familiaris)


name: RCHY1 monoubiquitinates POLH (Canis familiaris)


name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Canis familiaris)


name: SPRTN binds monoUb:K164-PCNA associated with POLH (Canis familiaris)


name: POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Canis familiaris)


name: Translesion Synthesis by POLH (Bos taurus)


name: POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Bos taurus)


name: SPRTN binds monoUb:K164-PCNA associated with POLH (Bos taurus)


name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Bos taurus)


name: RCHY1 monoubiquitinates POLH (Bos taurus)


name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Bos taurus)


name: Insertion of correct bases opposite the lesion by POLH (Bos taurus)


name: Translesion Synthesis by POLH (Sus scrofa)


name: POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Sus scrofa)


name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Sus scrofa)


name: SPRTN binds monoUb:K164-PCNA associated with POLH (Sus scrofa)


name: RCHY1 monoubiquitinates POLH (Sus scrofa)


name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Sus scrofa)


name: Insertion of correct bases opposite the lesion by POLH (Sus scrofa)


name: Translesion Synthesis by POLH (Danio rerio)


name: Insertion of correct bases opposite the lesion by POLH (Danio rerio)


name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Danio rerio)


name: RCHY1 monoubiquitinates POLH (Danio rerio)


name: SPRTN binds monoUb:K164-PCNA associated with POLH (Danio rerio)


name: POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Danio rerio)


name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Danio rerio)


name: Translesion Synthesis by POLH (Xenopus tropicalis)


name: POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Xenopus tropicalis)


name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Xenopus tropicalis)


name: Insertion of correct bases opposite the lesion by POLH (Xenopus tropicalis)


name: RCHY1 monoubiquitinates POLH (Xenopus tropicalis)


name: SPRTN binds monoUb:K164-PCNA associated with POLH (Xenopus tropicalis)


name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Xenopus tropicalis)


name: Translesion Synthesis by POLH (Gallus gallus)


name: SPRTN binds monoUb:K164-PCNA associated with POLH (Gallus gallus)


name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Gallus gallus)


name: POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Gallus gallus)


name: RCHY1 monoubiquitinates POLH (Gallus gallus)


name: Insertion of correct bases opposite the lesion by POLH (Gallus gallus)


name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Gallus gallus)


name: Translesion Synthesis by POLH (Drosophila melanogaster)


name: Insertion of correct bases opposite the lesion by POLH (Drosophila melanogaster)


name: SPRTN binds monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)


name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)


name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Drosophila melanogaster)


name: RCHY1 monoubiquitinates POLH (Drosophila melanogaster)


name: RCHY1 binds POLH (Drosophila melanogaster)


name: POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Drosophila melanogaster)


name: Elongation by POLH (Drosophila melanogaster)


name: Translesion Synthesis by POLH (Caenorhabditis elegans)


name: SPRTN binds monoUb:K164-PCNA associated with POLH (Caenorhabditis elegans)


name: Elongation by POLH (Caenorhabditis elegans)


name: POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Caenorhabditis elegans)


name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Caenorhabditis elegans)


name: Insertion of correct bases opposite the lesion by POLH (Caenorhabditis elegans)


name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Caenorhabditis elegans)


name: Translesion Synthesis by POLH (Schizosaccharomyces pombe)


name: Insertion of correct bases opposite the lesion by POLH (Schizosaccharomyces pombe)


name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Schizosaccharomyces pombe)


name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Schizosaccharomyces pombe)


name: Elongation by POLH (Schizosaccharomyces pombe)


name: POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Schizosaccharomyces pombe)


name: Translesion Synthesis by POLH (Saccharomyces cerevisiae)


name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Saccharomyces cerevisiae)


name: Insertion of correct bases opposite the lesion by POLH (Saccharomyces cerevisiae)


name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Saccharomyces cerevisiae)


name: Elongation by POLH (Saccharomyces cerevisiae)


name: POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Saccharomyces cerevisiae)


name: Translesion Synthesis by POLH (Plasmodium falciparum)


name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Plasmodium falciparum)


name: Insertion of correct bases opposite the lesion by POLH (Plasmodium falciparum)


name: SPRTN binds monoUb:K164-PCNA associated with POLH (Plasmodium falciparum)


name: Elongation by POLH (Plasmodium falciparum)


name: Translesion synthesis by REV1 (Homo sapiens)


name: POLZ extends translesion synthesis (Homo sapiens)


deoxycytidyl transferase activity

description: Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA.


name: Formation of Pol zeta complex (Homo sapiens)


name: REV1 recruits POLZ to (AP:Cyt)-DNA Template (Homo sapiens)


name: Translesion synthesis by REV1 (Mus musculus)


name: REV1 recruits POLZ to (AP:Cyt)-DNA Template (Mus musculus)


name: REV1 inserts dCMP opposite to AP sites in DNA (Mus musculus)


name: POLZ extends translesion synthesis (Mus musculus)


name: Formation of Pol zeta complex (Mus musculus)


name: Translesion synthesis by REV1 (Rattus norvegicus)


name: POLZ extends translesion synthesis (Rattus norvegicus)


name: REV1 inserts dCMP opposite to AP sites in DNA (Rattus norvegicus)


name: Formation of Pol zeta complex (Rattus norvegicus)


name: REV1 recruits POLZ to (AP:Cyt)-DNA Template (Rattus norvegicus)


name: Translesion synthesis by REV1 (Canis familiaris)


name: REV1 inserts dCMP opposite to AP sites in DNA (Canis familiaris)


name: Formation of Pol zeta complex (Canis familiaris)


name: REV1 recruits POLZ to (AP:Cyt)-DNA Template (Canis familiaris)


name: POLZ extends translesion synthesis (Canis familiaris)


name: Translesion synthesis by REV1 (Bos taurus)


name: POLZ extends translesion synthesis (Bos taurus)


name: REV1 recruits POLZ to (AP:Cyt)-DNA Template (Bos taurus)


name: REV1 inserts dCMP opposite to AP sites in DNA (Bos taurus)


name: Formation of Pol zeta complex (Bos taurus)


name: Translesion synthesis by REV1 (Sus scrofa)


name: POLZ extends translesion synthesis (Sus scrofa)


name: Formation of Pol zeta complex (Sus scrofa)


name: REV1 recruits POLZ to (AP:Cyt)-DNA Template (Sus scrofa)


name: REV1 inserts dCMP opposite to AP sites in DNA (Sus scrofa)


name: Translesion synthesis by REV1 (Danio rerio)


name: REV1 inserts dCMP opposite to AP sites in DNA (Danio rerio)


name: Translesion synthesis by REV1 (Xenopus tropicalis)


name: POLZ extends translesion synthesis (Xenopus tropicalis)


name: REV1 inserts dCMP opposite to AP sites in DNA (Xenopus tropicalis)


name: REV1 binds AP-dsDNA (Xenopus tropicalis)


name: Formation of Pol zeta complex (Xenopus tropicalis)


name: REV1 recruits POLZ to (AP:Cyt)-DNA Template (Xenopus tropicalis)


name: Translesion synthesis by REV1 (Gallus gallus)


name: Formation of Pol zeta complex (Gallus gallus)


name: REV1 recruits POLZ to (AP:Cyt)-DNA Template (Gallus gallus)


name: REV1 inserts dCMP opposite to AP sites in DNA (Gallus gallus)


name: POLZ extends translesion synthesis (Gallus gallus)


name: Translesion synthesis by REV1 (Drosophila melanogaster)


name: REV1 recruits POLZ to (AP:Cyt)-DNA Template (Drosophila melanogaster)


name: REV1 inserts dCMP opposite to AP sites in DNA (Drosophila melanogaster)


name: Formation of Pol zeta complex (Drosophila melanogaster)


name: POLZ extends translesion synthesis (Drosophila melanogaster)


name: REV1 binds AP-dsDNA (Drosophila melanogaster)


name: Translesion synthesis by REV1 (Caenorhabditis elegans)


name: REV1 inserts dCMP opposite to AP sites in DNA (Caenorhabditis elegans)


name: REV1 binds AP-dsDNA (Caenorhabditis elegans)


name: Translesion synthesis by REV1 (Dictyostelium discoideum)


name: Formation of Pol zeta complex (Dictyostelium discoideum)


name: Translesion synthesis by REV1 (Schizosaccharomyces pombe)


name: REV1 binds AP-dsDNA (Schizosaccharomyces pombe)


name: REV1 recruits POLZ to (AP:Cyt)-DNA Template (Schizosaccharomyces pombe)


name: REV1 inserts dCMP opposite to AP sites in DNA (Schizosaccharomyces pombe)


name: POLZ extends translesion synthesis (Schizosaccharomyces pombe)


name: Formation of Pol zeta complex (Schizosaccharomyces pombe)


name: Translesion synthesis by REV1 (Saccharomyces cerevisiae)


name: REV1 binds AP-dsDNA (Saccharomyces cerevisiae)


name: REV1 recruits POLZ to (AP:Cyt)-DNA Template (Saccharomyces cerevisiae)


name: REV1 inserts dCMP opposite to AP sites in DNA (Saccharomyces cerevisiae)


name: Formation of Pol zeta complex (Saccharomyces cerevisiae)


name: POLZ extends translesion synthesis (Saccharomyces cerevisiae)


name: Translesion synthesis by REV1 (Plasmodium falciparum)


name: POLZ extends translesion synthesis (Plasmodium falciparum)


name: REV1 recruits POLZ to (AP:Cyt)-DNA Template (Plasmodium falciparum)


name: REV1 binds AP-dsDNA (Plasmodium falciparum)


name: Formation of Pol zeta complex (Plasmodium falciparum)


name: REV1 inserts dCMP opposite to AP sites in DNA (Plasmodium falciparum)


name: Translesion synthesis by POLI (Homo sapiens)


name: POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Homo sapiens)


name: POLZ elongates POLI-incorporated dNMP (Homo sapiens)


name: POLI incorporates dNMP opposite to damaged DNA base (Homo sapiens)


name: Translesion synthesis by POLI (Mus musculus)


name: POLI incorporates dNMP opposite to damaged DNA base (Mus musculus)


name: POLZ elongates POLI-incorporated dNMP (Mus musculus)


name: POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Mus musculus)


name: Translesion synthesis by POLI (Rattus norvegicus)


name: POLI incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)


name: POLZ elongates POLI-incorporated dNMP (Rattus norvegicus)


name: POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Rattus norvegicus)


name: Translesion synthesis by POLI (Canis familiaris)


name: POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Canis familiaris)


name: POLI incorporates dNMP opposite to damaged DNA base (Canis familiaris)


name: POLZ elongates POLI-incorporated dNMP (Canis familiaris)


name: Translesion synthesis by POLI (Bos taurus)


name: POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Bos taurus)


name: POLZ elongates POLI-incorporated dNMP (Bos taurus)


name: POLI incorporates dNMP opposite to damaged DNA base (Bos taurus)


name: Translesion synthesis by POLI (Sus scrofa)


name: POLI incorporates dNMP opposite to damaged DNA base (Sus scrofa)


name: POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Sus scrofa)


name: POLZ elongates POLI-incorporated dNMP (Sus scrofa)


name: Translesion synthesis by POLI (Danio rerio)


name: POLI incorporates dNMP opposite to damaged DNA base (Danio rerio)


name: Translesion synthesis by POLI (Xenopus tropicalis)


name: POLI incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)


name: POLZ elongates POLI-incorporated dNMP (Xenopus tropicalis)


name: POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Xenopus tropicalis)


name: Translesion synthesis by POLI (Gallus gallus)


name: POLI incorporates dNMP opposite to damaged DNA base (Gallus gallus)


name: POLZ elongates POLI-incorporated dNMP (Gallus gallus)


name: Translesion synthesis by POLI (Drosophila melanogaster)


name: POLZ elongates POLI-incorporated dNMP (Drosophila melanogaster)


name: POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Drosophila melanogaster)


name: POLI incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)


name: Translesion synthesis by POLI (Caenorhabditis elegans)


name: POLI incorporates dNMP opposite to damaged DNA base (Caenorhabditis elegans)


name: Translesion synthesis by POLI (Schizosaccharomyces pombe)


name: POLZ elongates POLI-incorporated dNMP (Schizosaccharomyces pombe)


name: POLI incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)


name: Translesion synthesis by POLI (Saccharomyces cerevisiae)


name: POLI incorporates dNMP opposite to damaged DNA base (Saccharomyces cerevisiae)


name: POLZ elongates POLI-incorporated dNMP (Saccharomyces cerevisiae)


name: Translesion synthesis by POLI (Plasmodium falciparum)


name: POLI incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)


name: POLZ elongates POLI-incorporated dNMP (Plasmodium falciparum)


name: Termination of translesion DNA synthesis (Homo sapiens)


name: KIAA0101 double monoubiquitination (Homo sapiens)


name: USP43 deISGylates ISG:K164,ISG:K168-PCNA (Homo sapiens)


name: USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)


ISG15 transferase activity

description: Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages.


name: TRIM25 binds monoUb:164-PCNA (Homo sapiens)


name: POLD,POLE binds deISGylated PCNA after TLS (Homo sapiens)


name: POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)


name: USP43 binds ISG:K164,ISG:K168-PCNA (Homo sapiens)


name: USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)


name: Termination of translesion DNA synthesis (Mus musculus)


name: UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Mus musculus)


name: KIAA0101 double monoubiquitination (Mus musculus)


name: USP43 deISGylates ISG:K164,ISG:K168-PCNA (Mus musculus)


name: POLD,POLE binds deISGylated PCNA after TLS (Mus musculus)


name: USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)


name: USP43 binds ISG:K164,ISG:K168-PCNA (Mus musculus)


name: TRIM25 binds monoUb:164-PCNA (Mus musculus)


name: USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)


name: Termination of translesion DNA synthesis (Rattus norvegicus)


name: TRIM25 binds monoUb:164-PCNA (Rattus norvegicus)


name: USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)


name: POLD,POLE binds deISGylated PCNA after TLS (Rattus norvegicus)


name: USP43 deISGylates ISG:K164,ISG:K168-PCNA (Rattus norvegicus)


name: UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Rattus norvegicus)


name: USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)


name: USP43 binds ISG:K164,ISG:K168-PCNA (Rattus norvegicus)


name: KIAA0101 double monoubiquitination (Rattus norvegicus)


name: Termination of translesion DNA synthesis (Canis familiaris)


name: USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)


name: KIAA0101 double monoubiquitination (Canis familiaris)


name: USP43 deISGylates ISG:K164,ISG:K168-PCNA (Canis familiaris)


name: USP43 binds ISG:K164,ISG:K168-PCNA (Canis familiaris)


name: POLD,POLE binds deISGylated PCNA after TLS (Canis familiaris)


name: USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)


name: Termination of translesion DNA synthesis (Bos taurus)


name: USP43 deISGylates ISG:K164,ISG:K168-PCNA (Bos taurus)


name: UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Bos taurus)


name: KIAA0101 double monoubiquitination (Bos taurus)


name: USP43 binds ISG:K164,ISG:K168-PCNA (Bos taurus)


name: TRIM25 binds monoUb:164-PCNA (Bos taurus)


name: POLD,POLE binds deISGylated PCNA after TLS (Bos taurus)


name: Termination of translesion DNA synthesis (Sus scrofa)


name: USP43 binds ISG:K164,ISG:K168-PCNA (Sus scrofa)


name: POLD,POLE binds deISGylated PCNA after TLS (Sus scrofa)


name: USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)


name: USP43 deISGylates ISG:K164,ISG:K168-PCNA (Sus scrofa)


name: UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Sus scrofa)


name: USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)


name: TRIM25 binds monoUb:164-PCNA (Sus scrofa)


name: KIAA0101 double monoubiquitination (Sus scrofa)


name: Termination of translesion DNA synthesis (Danio rerio)


name: TRIM25 binds monoUb:164-PCNA (Danio rerio)


name: Termination of translesion DNA synthesis (Xenopus tropicalis)


name: KIAA0101 double monoubiquitination (Xenopus tropicalis)


name: USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)


name: USP43 binds ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)


name: POLD,POLE binds deISGylated PCNA after TLS (Xenopus tropicalis)


name: TRIM25 binds monoUb:164-PCNA (Xenopus tropicalis)


name: USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)


name: Termination of translesion DNA synthesis (Gallus gallus)


name: TRIM25 binds monoUb:164-PCNA (Gallus gallus)


name: POLD,POLE binds deISGylated PCNA after TLS (Gallus gallus)


name: USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)


name: KIAA0101 double monoubiquitination (Gallus gallus)


name: USP43 binds ISG:K164,ISG:K168-PCNA (Gallus gallus)


name: USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)


name: Termination of translesion DNA synthesis (Drosophila melanogaster)


name: USP43 binds ISG:K164,ISG:K168-PCNA (Drosophila melanogaster)


name: USP43 deISGylates ISG:K164,ISG:K168-PCNA (Drosophila melanogaster)


name: POLD,POLE binds deISGylated PCNA after TLS (Drosophila melanogaster)


name: Termination of translesion DNA synthesis (Caenorhabditis elegans)


name: POLD,POLE binds deISGylated PCNA after TLS (Caenorhabditis elegans)


name: Termination of translesion DNA synthesis (Dictyostelium discoideum)


name: POLD,POLE binds deISGylated PCNA after TLS (Dictyostelium discoideum)


name: Termination of translesion DNA synthesis (Schizosaccharomyces pombe)


name: USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)


name: POLD,POLE binds deISGylated PCNA after TLS (Schizosaccharomyces pombe)


name: USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)


name: Termination of translesion DNA synthesis (Saccharomyces cerevisiae)


name: USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Saccharomyces cerevisiae)


name: USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Saccharomyces cerevisiae)


name: POLD,POLE binds deISGylated PCNA after TLS (Saccharomyces cerevisiae)


name: Termination of translesion DNA synthesis (Plasmodium falciparum)


name: USP43 binds ISG:K164,ISG:K168-PCNA (Plasmodium falciparum)


name: USP43 deISGylates ISG:K164,ISG:K168-PCNA (Plasmodium falciparum)


name: POLD,POLE binds deISGylated PCNA after TLS (Plasmodium falciparum)


name: Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)


name: USP1:WDR48 binds monoUb:K164-PCNA (Homo sapiens)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)


name: Damaged dsDNA becomes damaged DNA template (Homo sapiens)


name: PCNA-containing replication complex binds damaged dsDNA (Homo sapiens)


name: USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Homo sapiens)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)


name: Recognition of DNA damage by PCNA-containing replication complex (Mus musculus)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Mus musculus)


name: USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Mus musculus)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Mus musculus)


name: USP1:WDR48 binds monoUb:K164-PCNA (Mus musculus)


name: Recognition of DNA damage by PCNA-containing replication complex (Rattus norvegicus)


name: USP1:WDR48 binds monoUb:K164-PCNA (Rattus norvegicus)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Rattus norvegicus)


name: USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Rattus norvegicus)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Rattus norvegicus)


name: Recognition of DNA damage by PCNA-containing replication complex (Canis familiaris)


name: USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Canis familiaris)


name: USP1:WDR48 binds monoUb:K164-PCNA (Canis familiaris)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Canis familiaris)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Canis familiaris)


name: Recognition of DNA damage by PCNA-containing replication complex (Bos taurus)


name: USP1:WDR48 binds monoUb:K164-PCNA (Bos taurus)


name: USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Bos taurus)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Bos taurus)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Bos taurus)


name: Recognition of DNA damage by PCNA-containing replication complex (Sus scrofa)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Sus scrofa)


name: USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Sus scrofa)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Sus scrofa)


name: USP1:WDR48 binds monoUb:K164-PCNA (Sus scrofa)


name: Recognition of DNA damage by PCNA-containing replication complex (Danio rerio)


name: USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Danio rerio)


name: USP1:WDR48 binds monoUb:K164-PCNA (Danio rerio)


name: Recognition of DNA damage by PCNA-containing replication complex (Xenopus tropicalis)


name: USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Xenopus tropicalis)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Xenopus tropicalis)


name: USP1:WDR48 binds monoUb:K164-PCNA (Xenopus tropicalis)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Xenopus tropicalis)


name: Recognition of DNA damage by PCNA-containing replication complex (Gallus gallus)


name: USP1:WDR48 binds monoUb:K164-PCNA (Gallus gallus)


name: USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Gallus gallus)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Gallus gallus)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Gallus gallus)


name: Recognition of DNA damage by PCNA-containing replication complex (Drosophila melanogaster)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Drosophila melanogaster)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Drosophila melanogaster)


name: Recognition of DNA damage by PCNA-containing replication complex (Caenorhabditis elegans)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Caenorhabditis elegans)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Caenorhabditis elegans)


name: Recognition of DNA damage by PCNA-containing replication complex (Dictyostelium discoideum)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Dictyostelium discoideum)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Dictyostelium discoideum)


name: Recognition of DNA damage by PCNA-containing replication complex (Schizosaccharomyces pombe)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Schizosaccharomyces pombe)


name: USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Schizosaccharomyces pombe)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Schizosaccharomyces pombe)


name: USP1:WDR48 binds monoUb:K164-PCNA (Schizosaccharomyces pombe)


name: USP1 autocleavage (Schizosaccharomyces pombe)


name: Recognition of DNA damage by PCNA-containing replication complex (Plasmodium falciparum)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Plasmodium falciparum)


name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Plasmodium falciparum)


name: MGMT-mediated DNA damage reversal (Homo sapiens)


name: MGMT/hAGT mediated DNA Damage Reversal (Homo sapiens)


name: MGMT binds alkylated DNA containing 6-O-methylguanine (Homo sapiens)


name: Reversal of alkylation damage by DNA dioxygenases (Homo sapiens)


oxidative RNA demethylase activity

description: Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.


name: ALKBH2 mediated reversal of alkylation damage (Homo sapiens)


name: ALKBH2 binds alkylated DNA containing 1-meA (Homo sapiens)


name: Oxidative demethylation of 3-meC damaged DNA by ALKBH2 (Homo sapiens)


name: Oxidative dealkylation of 1-etA damaged DNA By ALKBH2 (Homo sapiens)


name: ALKBH2 binds alkylated DNA containing 1-etA (Homo sapiens)


name: ALKBH2 binds alkylated dsDNA containing 3-meC (Homo sapiens)


name: Oxidative demethylation of 1-meA damaged DNA by ALKBH2 (Homo sapiens)


name: ALKBH3 mediated reversal of alkylation damage (Homo sapiens)


name: Oxidative demethylation of 3-meC damaged DNA By ALKBH3 (Homo sapiens)


name: Oxidative dealkylation of 1-EtA damaged DNA by ABH3 (Homo sapiens)


name: ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA (Homo sapiens)


name: Oxidative demethylation of 1-meA damaged DNA By ALKBH3 (Homo sapiens)


name: ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC (Homo sapiens)


name: ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA (Homo sapiens)


name: Reversal of alkylation damage by DNA dioxygenases (Mus musculus)


name: RNA demethylases demethylate N6-methyladenosine RNA (Mus musculus)


name: Reversal of alkylation damage by DNA dioxygenases (Rattus norvegicus)


name: RNA demethylases demethylate N6-methyladenosine RNA (Rattus norvegicus)


name: Reversal of alkylation damage by DNA dioxygenases (Canis familiaris)


name: RNA demethylases demethylate N6-methyladenosine RNA (Canis familiaris)


name: Reversal of alkylation damage by DNA dioxygenases (Bos taurus)


name: RNA demethylases demethylate N6-methyladenosine RNA (Bos taurus)


name: Reversal of alkylation damage by DNA dioxygenases (Sus scrofa)


name: RNA demethylases demethylate N6-methyladenosine RNA (Sus scrofa)


name: Reversal of alkylation damage by DNA dioxygenases (Danio rerio)


name: RNA demethylases demethylate N6-methyladenosine RNA (Danio rerio)


name: Reversal of alkylation damage by DNA dioxygenases (Xenopus tropicalis)


name: RNA demethylases demethylate N6-methyladenosine RNA (Xenopus tropicalis)


name: Reversal of alkylation damage by DNA dioxygenases (Gallus gallus)


name: RNA demethylases demethylate N6-methyladenosine RNA (Gallus gallus)


name: Reversible DNA damage induced by alkylating chemotherapeutic drugs (Homo sapiens)


name: Triazenes produce DNA damage in the form of O6-methylguanine (Homo sapiens)


name: Unknown efflux pump transports glucuronidated PRED metabolite (Homo sapiens)


name: PREDN,PREDL diffuse into kidney cells (Homo sapiens)


name: CYP3A4 oxidizes PREDN,PREDL (Homo sapiens)


name: ABCB1 transports PREDN,PREDL out of kidney cells (Homo sapiens)


name: steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative.


name: HSD11B2 dehydrogenates PREDL to PREDN (Homo sapiens)


name: PREDN,PREDL diffuse into GI cells (Homo sapiens)


name: ABCB1 transports PREDN,PREDL out of hepatic cells (Homo sapiens)


name: UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Homo sapiens)


name: ABCB1 transports xenobiotics out of the cell (Homo sapiens)


name: PREDL:ALB dissociates (Homo sapiens)


name: PREDN,PREDL diffuse into hepatic cells (Homo sapiens)


name: PREDN:ALB dissociates (Homo sapiens)


name: HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Homo sapiens)


name: PREDN:ALB dissociates (Mus musculus)


name: PREDL:ALB dissociates (Mus musculus)


name: AKR1C1 hydrogenates PREDN,PREDL (Mus musculus)


name: HSD11B2 dehydrogenates PREDL to PREDN (Mus musculus)


name: HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Mus musculus)


name: ABCB1 transports PREDN,PREDL out of hepatic cells (Mus musculus)


name: ABCB1 transports PREDN,PREDL out of kidney cells (Mus musculus)


name: CYP3A4 oxidizes PREDN,PREDL (Mus musculus)


name: UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Mus musculus)


name: ABCB1 transports xenobiotics out of the cell (Mus musculus)


name: HSD11B2 dehydrogenates PREDL to PREDN (Rattus norvegicus)


name: ABCB1 transports PREDN,PREDL out of kidney cells (Rattus norvegicus)


name: ABCB1 transports PREDN,PREDL out of hepatic cells (Rattus norvegicus)


name: UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Rattus norvegicus)


name: PREDL:ALB dissociates (Rattus norvegicus)


name: SERPINA6 binds PREDN (Rattus norvegicus)


name: PREDN:ALB dissociates (Rattus norvegicus)


name: SERPINA6 binds PREDL (Rattus norvegicus)


name: ABCB1 transports xenobiotics out of the cell (Rattus norvegicus)


name: CYP3A4 oxidizes PREDN,PREDL (Rattus norvegicus)


name: AKR1C1 hydrogenates PREDN,PREDL (Rattus norvegicus)


name: HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Rattus norvegicus)


name: HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Canis familiaris)


name: ABCB1 transports PREDN,PREDL out of hepatic cells (Canis familiaris)


name: UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Canis familiaris)


name: CYP3A4 oxidizes PREDN,PREDL (Canis familiaris)


name: ABCB1 transports xenobiotics out of the cell (Canis familiaris)


name: PREDL:ALB dissociates (Canis familiaris)


name: PREDN:ALB dissociates (Canis familiaris)


name: ABCB1 transports PREDN,PREDL out of kidney cells (Canis familiaris)


name: HSD11B2 dehydrogenates PREDL to PREDN (Canis familiaris)


name: UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Bos taurus)


name: CYP3A4 oxidizes PREDN,PREDL (Bos taurus)


name: ABCB1 transports xenobiotics out of the cell (Bos taurus)


name: AKR1C1 hydrogenates PREDN,PREDL (Bos taurus)


name: PREDL:ALB dissociates (Bos taurus)


name: PREDN:ALB dissociates (Bos taurus)


name: HSD11B2 dehydrogenates PREDL to PREDN (Bos taurus)


name: ABCB1 transports PREDN,PREDL out of kidney cells (Bos taurus)


name: ABCB1 transports PREDN,PREDL out of hepatic cells (Bos taurus)


name: ABCB1 transports PREDN,PREDL out of kidney cells (Sus scrofa)


name: HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Sus scrofa)


name: ABCB1 transports PREDN,PREDL out of hepatic cells (Sus scrofa)


name: ABCB1 transports xenobiotics out of the cell (Sus scrofa)


name: PREDL:ALB dissociates (Sus scrofa)


name: PREDN:ALB dissociates (Sus scrofa)


name: UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Sus scrofa)


name: CYP3A4 oxidizes PREDN,PREDL (Sus scrofa)


name: AKR1C1 hydrogenates PREDN,PREDL (Sus scrofa)


name: HSD11B2 dehydrogenates PREDL to PREDN (Sus scrofa)


name: HSD11B2 dehydrogenates PREDL to PREDN (Danio rerio)


name: CYP3A4 oxidizes PREDN,PREDL (Danio rerio)


name: UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Danio rerio)


name: HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Danio rerio)


name: HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Xenopus tropicalis)


name: CYP3A4 oxidizes PREDN,PREDL (Xenopus tropicalis)


name: SERPINA6 binds PREDN (Xenopus tropicalis)


name: SERPINA6 binds PREDL (Xenopus tropicalis)


name: PREDN:ALB dissociates (Xenopus tropicalis)


name: PREDL:ALB dissociates (Xenopus tropicalis)


name: AKR1C1 hydrogenates PREDN,PREDL (Xenopus tropicalis)


name: HSD11B2 dehydrogenates PREDL to PREDN (Xenopus tropicalis)


name: HSD11B2 dehydrogenates PREDL to PREDN (Gallus gallus)


name: HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Gallus gallus)


name: CYP3A4 oxidizes PREDN,PREDL (Gallus gallus)


name: ABCB1 transports xenobiotics out of the cell (Gallus gallus)


name: UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Gallus gallus)


name: PREDN:ALB dissociates (Gallus gallus)


name: ABCB1 transports PREDN,PREDL out of kidney cells (Gallus gallus)


name: ABCB1 transports PREDN,PREDL out of hepatic cells (Gallus gallus)


name: PREDL:ALB dissociates (Gallus gallus)


name: Prednisone ADME (Drosophila melanogaster)


name: SERPINA6 binds PREDL (Drosophila melanogaster)


name: UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Drosophila melanogaster)


name: SERPINA6 binds PREDN (Drosophila melanogaster)


name: AKR1C1 hydrogenates PREDN,PREDL (Drosophila melanogaster)


name: HSD11B2 dehydrogenates PREDL to PREDN (Drosophila melanogaster)


name: Prednisone ADME (Caenorhabditis elegans)


name: AKR1C1 hydrogenates PREDN,PREDL (Caenorhabditis elegans)


name: SERPINA6 binds PREDN (Caenorhabditis elegans)


name: UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Caenorhabditis elegans)


name: SERPINA6 binds PREDL (Caenorhabditis elegans)


name: Prednisone ADME (Dictyostelium discoideum)


name: ABCB1 transports xenobiotics out of the cell (Dictyostelium discoideum)


name: UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Dictyostelium discoideum)


name: ABCB1 transports PREDN,PREDL out of kidney cells (Dictyostelium discoideum)


name: ABCB1 transports PREDN,PREDL out of hepatic cells (Dictyostelium discoideum)


name: AKR1C1 hydrogenates PREDN,PREDL (Dictyostelium discoideum)


name: Prednisone ADME (Schizosaccharomyces pombe)


name: AKR1C1 hydrogenates PREDN,PREDL (Schizosaccharomyces pombe)


name: ABCB1 transports xenobiotics out of the cell (Schizosaccharomyces pombe)


name: HSD11B2 dehydrogenates PREDL to PREDN (Schizosaccharomyces pombe)


name: ABCB1 transports PREDN,PREDL out of kidney cells (Schizosaccharomyces pombe)


name: ABCB1 transports PREDN,PREDL out of hepatic cells (Schizosaccharomyces pombe)


name: Prednisone ADME (Saccharomyces cerevisiae)


name: AKR1C1 hydrogenates PREDN,PREDL (Saccharomyces cerevisiae)


name: ABCB1 transports xenobiotics out of the cell (Plasmodium falciparum)


name: ABCB1 transports PREDN,PREDL out of kidney cells (Plasmodium falciparum)


name: ABCB1 transports PREDN,PREDL out of hepatic cells (Plasmodium falciparum)


name: SLC29A1 transports RBV from cytosol to extracellular region (Homo sapiens)


name: Unknown kinase phosphorylates RBV-MP (Homo sapiens)


name: SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Homo sapiens)


name: SLC29A1 transports RBV from extracellular region to cytosol (Homo sapiens)


name: NT5C2 tetramer dephosphorylates RBV-MP (Homo sapiens)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Homo sapiens)


name: SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Homo sapiens)


name: NME1,2 hexamers phosphorylate RBV-DP (Homo sapiens)


name: PNP trimer transforms RBV to T-CONH2 (Homo sapiens)


name: NT5C2 tetramer phosphorylates RBV (Homo sapiens)


name: NME1,2 hexamers phosphorylate RBV-DP (Mus musculus)


name: NT5C2 tetramer dephosphorylates RBV-MP (Mus musculus)


name: PNP trimer transforms RBV to T-CONH2 (Mus musculus)


name: SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Mus musculus)


name: SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Mus musculus)


name: SLC29A1 transports RBV from cytosol to extracellular region (Mus musculus)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Mus musculus)


name: NT5C2 tetramer phosphorylates RBV (Mus musculus)


name: SLC29A1 transports RBV from extracellular region to cytosol (Mus musculus)


name: SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Rattus norvegicus)


name: SLC29A1 transports RBV from cytosol to extracellular region (Rattus norvegicus)


name: PNP trimer transforms RBV to T-CONH2 (Rattus norvegicus)


name: SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Rattus norvegicus)


name: NT5C2 tetramer phosphorylates RBV (Rattus norvegicus)


name: SLC29A1 transports RBV from extracellular region to cytosol (Rattus norvegicus)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Rattus norvegicus)


name: NME1,2 hexamers phosphorylate RBV-DP (Rattus norvegicus)


name: NT5C2 tetramer dephosphorylates RBV-MP (Rattus norvegicus)


name: ADK phosphorylates RBV (Rattus norvegicus)


name: NME1,2 hexamers phosphorylate RBV-DP (Canis familiaris)


name: ADK phosphorylates RBV (Canis familiaris)


name: NT5C2 tetramer phosphorylates RBV (Canis familiaris)


name: SLC29A1 transports RBV from extracellular region to cytosol (Canis familiaris)


name: SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Canis familiaris)


name: SLC29A1 transports RBV from cytosol to extracellular region (Canis familiaris)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Canis familiaris)


name: NT5C2 tetramer dephosphorylates RBV-MP (Canis familiaris)


name: PNP trimer transforms RBV to T-CONH2 (Canis familiaris)


name: SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Canis familiaris)


name: NT5C2 tetramer phosphorylates RBV (Bos taurus)


name: SLC29A1 transports RBV from extracellular region to cytosol (Bos taurus)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Bos taurus)


name: SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Bos taurus)


name: SLC29A1 transports RBV from cytosol to extracellular region (Bos taurus)


name: PNP trimer transforms RBV to T-CONH2 (Bos taurus)


name: SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Bos taurus)


name: NT5C2 tetramer dephosphorylates RBV-MP (Bos taurus)


name: NME1,2 hexamers phosphorylate RBV-DP (Bos taurus)


name: NT5C2 tetramer phosphorylates RBV (Sus scrofa)


name: SLC29A1 transports RBV from extracellular region to cytosol (Sus scrofa)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Sus scrofa)


name: SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Sus scrofa)


name: SLC29A1 transports RBV from cytosol to extracellular region (Sus scrofa)


name: PNP trimer transforms RBV to T-CONH2 (Sus scrofa)


name: SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Sus scrofa)


name: NT5C2 tetramer dephosphorylates RBV-MP (Sus scrofa)


name: NME1,2 hexamers phosphorylate RBV-DP (Sus scrofa)


name: NME1,2 hexamers phosphorylate RBV-DP (Danio rerio)


name: PNP trimer transforms RBV to T-CONH2 (Danio rerio)


name: SLC29A1 transports RBV from cytosol to extracellular region (Danio rerio)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Danio rerio)


name: SLC29A1 transports RBV from extracellular region to cytosol (Danio rerio)


name: ADK phosphorylates RBV (Xenopus tropicalis)


name: SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Xenopus tropicalis)


name: NT5C2 tetramer dephosphorylates RBV-MP (Xenopus tropicalis)


name: NT5C2 tetramer phosphorylates RBV (Xenopus tropicalis)


name: PNP trimer transforms RBV to T-CONH2 (Xenopus tropicalis)


name: SLC29A1 transports RBV from cytosol to extracellular region (Xenopus tropicalis)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Xenopus tropicalis)


name: SLC29A1 transports RBV from extracellular region to cytosol (Xenopus tropicalis)


name: NME1,2 hexamers phosphorylate RBV-DP (Xenopus tropicalis)


name: SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Gallus gallus)


name: SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Gallus gallus)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Gallus gallus)


name: NT5C2 tetramer phosphorylates RBV (Gallus gallus)


name: NT5C2 tetramer dephosphorylates RBV-MP (Gallus gallus)


name: NME1,2 hexamers phosphorylate RBV-DP (Gallus gallus)


name: Ribavirin ADME (Drosophila melanogaster)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Drosophila melanogaster)


name: NT5C2 tetramer phosphorylates RBV (Drosophila melanogaster)


name: SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Drosophila melanogaster)


name: PNP trimer transforms RBV to T-CONH2 (Drosophila melanogaster)


name: SLC29A1 transports RBV from cytosol to extracellular region (Drosophila melanogaster)


name: ADK phosphorylates RBV (Drosophila melanogaster)


name: SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Drosophila melanogaster)


name: NT5C2 tetramer dephosphorylates RBV-MP (Drosophila melanogaster)


name: SLC29A1 transports RBV from extracellular region to cytosol (Drosophila melanogaster)


name: NME1,2 hexamers phosphorylate RBV-DP (Drosophila melanogaster)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Caenorhabditis elegans)


name: SLC29A1 transports RBV from extracellular region to cytosol (Caenorhabditis elegans)


name: NT5C2 tetramer phosphorylates RBV (Caenorhabditis elegans)


name: SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Caenorhabditis elegans)


name: PNP trimer transforms RBV to T-CONH2 (Caenorhabditis elegans)


name: SLC29A1 transports RBV from cytosol to extracellular region (Caenorhabditis elegans)


name: ADA deamidates RBV (Caenorhabditis elegans)


name: SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Caenorhabditis elegans)


name: NT5C2 tetramer dephosphorylates RBV-MP (Caenorhabditis elegans)


name: NME1,2 hexamers phosphorylate RBV-DP (Caenorhabditis elegans)


name: ADK phosphorylates RBV (Caenorhabditis elegans)


name: Ribavirin ADME (Dictyostelium discoideum)


name: SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Dictyostelium discoideum)


name: NT5C2 tetramer dephosphorylates RBV-MP (Dictyostelium discoideum)


name: ADA deamidates RBV (Dictyostelium discoideum)


name: ADK phosphorylates RBV (Dictyostelium discoideum)


name: NT5C2 tetramer phosphorylates RBV (Dictyostelium discoideum)


name: NME1,2 hexamers phosphorylate RBV-DP (Dictyostelium discoideum)


name: SLC29A1 transports RBV from extracellular region to cytosol (Dictyostelium discoideum)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Dictyostelium discoideum)


name: SLC29A1 transports RBV from cytosol to extracellular region (Dictyostelium discoideum)


name: Ribavirin ADME (Schizosaccharomyces pombe)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Schizosaccharomyces pombe)


name: PNP trimer transforms RBV to T-CONH2 (Schizosaccharomyces pombe)


name: ADK phosphorylates RBV (Schizosaccharomyces pombe)


name: NME1,2 hexamers phosphorylate RBV-DP (Schizosaccharomyces pombe)


name: Ribavirin ADME (Saccharomyces cerevisiae)


name: ADK phosphorylates RBV (Saccharomyces cerevisiae)


name: NME1,2 hexamers phosphorylate RBV-DP (Saccharomyces cerevisiae)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Saccharomyces cerevisiae)


name: PNP trimer transforms RBV to T-CONH2 (Saccharomyces cerevisiae)


name: SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Plasmodium falciparum)


name: ADA deamidates RBV (Plasmodium falciparum)


name: NME1,2 hexamers phosphorylate RBV-DP (Plasmodium falciparum)


name: SLC29A1 transports RBV from extracellular region to cytosol (Plasmodium falciparum)


name: ITPA dimer dephosphorylates RBV-TP to RBV-MP (Plasmodium falciparum)


name: SLC29A1 transports RBV from cytosol to extracellular region (Plasmodium falciparum)


name: NAT1,2 acetylate APAP-Cys to APAP-Mer (Homo sapiens)


name: ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Homo sapiens)


name: GGT dimers hydrolyse APAP-SG (Homo sapiens)


name: CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Homo sapiens)


name: GSTs transfer GSH to NAPQI to form APAP-SG (Homo sapiens)


name: CYP2E1 monooxygenates APAP to NAPQI (Homo sapiens)


name: ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Homo sapiens)


name: UGTs glucuronate APAP to APAP-GlcA (Homo sapiens)


name: APAP translocates from extracellular region to cytosol (Homo sapiens)


name: ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Homo sapiens)


name: ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Homo sapiens)


name: SULT dimers sulfate APAP to APAP-SO3 (Homo sapiens)


name: NAPQI binds proteins in hepatocytes (Homo sapiens)


name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)


name: PGH2 is isomerised to PGD2 by HPGDS (Homo sapiens)


name: Prostaglandin E synthase isomerizes PGH2 to PGE2 (Homo sapiens)


name: PGE2 is converted to PGF2a by CBR1 (Homo sapiens)


name: Delta12-PGJ2 is dehydrated to 15d-PGJ2 (Homo sapiens)


name: PTGS1 dimer binds PTGS1 Inhibitors (Homo sapiens)

definition: Inhibition


name: PGE2 is dehydrated to PGA2 (Homo sapiens)


name: PGH2 is isomerised to PGE2 by PTGES (Homo sapiens)


name: PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD (Homo sapiens)


name: PGA2 is isomerised to PGC2 (Homo sapiens)


name: PGA2 is dehydrated to 15d-PGA2 (Homo sapiens)


name: TXB2 is converted to 11dh-TXB2 by TXDH (Homo sapiens)


name: PGD2 is dehydrated to PGJ2 (Homo sapiens)


name: PGC2 is isomerised to PGB2 (Homo sapiens)


name: PGD2 is dehydrated to 15d-PGD2 (Homo sapiens)


name: PGH2 is reduced to PGF2a by FAM213B (Homo sapiens)


name: PGH2 is reduced to PGF2a by AKR1C3 (Homo sapiens)


name: PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Homo sapiens)


name: PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol (Homo sapiens)


name: PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Homo sapiens)


name: PTGS2 dimer binds PTGS2 inhibitors (Homo sapiens)


name: TXA2 is hydrolysed to TXB2 (Homo sapiens)


name: PGI2 is hydrolysed to 6k-PGF1a (Homo sapiens)


name: PGH2 is isomerised to PGD2 by PTGDS (Homo sapiens)


name: Arachidonic acid is oxidised to PGG2 by PTGS2 (Homo sapiens)


name: PGJ2 is isomerised to delta12-PGJ2 (Homo sapiens)


name: 15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1 (Homo sapiens)


name: Hydroxyl radicals oxidize ST to 2,3-DHBA (Homo sapiens)


name: 2,5-DHBA translocates from ER lumen to mitochondrial matrix (Homo sapiens)


name: ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Homo sapiens)


name: ST metabolites diffuse out of ER lumen (Homo sapiens)


name: Glycine conjugates translocates from mitochondrial matrix to cytosol (Homo sapiens)


name: ST translocates from ER lumen to cytosol of GI cells (Homo sapiens)


name: CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)


name: ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Homo sapiens)


name: ASA- (GI) translocates from cytosol to extracellular region (Homo sapiens)


name: ST translocates from cytosol to mitochondrial matrix of hepatocytes (Homo sapiens)


name: SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Homo sapiens)


name: ST translocates from cytosol to extracellular region (Homo sapiens)


name: ASA-,ST translocate from cytosol to ER lumen of hepatocytes (Homo sapiens)


name: GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Homo sapiens)


name: ASA- translocates from cytosol to ER lumen of GI cells (Homo sapiens)


name: Acetylsalicylic acid dissolves (Homo sapiens)


name: SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Homo sapiens)


name: CES1,CES2 hydrolyze ASA- to ST (Homo sapiens)


name: CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Homo sapiens)


name: SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Mus musculus)


name: ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Mus musculus)


name: CES1,CES2 hydrolyze ASA- to ST (Mus musculus)


name: CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Mus musculus)


name: SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Mus musculus)


name: GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Mus musculus)


name: ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Mus musculus)


name: CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Mus musculus)


name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Mus musculus)


name: PGH2 is isomerised to PGD2 by HPGDS (Mus musculus)


name: PTGS1 dimer binds PTGS1 Inhibitors (Mus musculus)


name: PGH2 is reduced to PGF2a by AKR1C3 (Mus musculus)


name: PGH2 is isomerised to PGE2 by PTGES (Mus musculus)


name: PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Mus musculus)


name: PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Mus musculus)


name: PTGS2 dimer binds PTGS2 inhibitors (Mus musculus)


name: Prostaglandin E synthase isomerizes PGH2 to PGE2 (Mus musculus)


name: PGH2 is isomerised to PGD2 by PTGDS (Mus musculus)


name: Arachidonic acid is oxidised to PGG2 by PTGS2 (Mus musculus)


name: PGE2 is converted to PGF2a by CBR1 (Mus musculus)


name: CES2 hydrolyzes ASA- (Rattus norvegicus)


name: CES1,CES2 hydrolyze ASA- to ST (Rattus norvegicus)


name: SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Rattus norvegicus)


name: BCHE hydrolyzes ASA- (Rattus norvegicus)


name: UGT1A6 glucuronates ST (Rattus norvegicus)


name: ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Rattus norvegicus)


name: CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Rattus norvegicus)


name: SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Rattus norvegicus)


name: CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Rattus norvegicus)


name: GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Rattus norvegicus)


name: ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Rattus norvegicus)


name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Rattus norvegicus)


name: PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Rattus norvegicus)


name: PGH2 is isomerised to PGE2 by PTGES (Rattus norvegicus)


name: PTGS1 dimer binds PTGS1 Inhibitors (Rattus norvegicus)


name: PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Rattus norvegicus)


name: Arachidonic acid is oxidised to PGG2 by PTGS2 (Rattus norvegicus)


name: PGH2 is reduced to PGF2a by AKR1C3 (Rattus norvegicus)


name: PTGS2 dimer binds PTGS2 inhibitors (Rattus norvegicus)


name: ASA- acetylates PTGS2 (Rattus norvegicus)


name: ASA- acetylates PTGS1 (Rattus norvegicus)


name: PGH2 is isomerised to PGD2 by HPGDS (Rattus norvegicus)


name: PGH2 is isomerised to PGD2 by PTGDS (Rattus norvegicus)


name: Prostaglandin E synthase isomerizes PGH2 to PGE2 (Rattus norvegicus)


name: PGE2 is converted to PGF2a by CBR1 (Rattus norvegicus)


name: CES1,CES2 hydrolyze ASA- to ST (Canis familiaris)


name: ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Canis familiaris)


name: CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Canis familiaris)


name: ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Canis familiaris)


name: SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Canis familiaris)


name: CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Canis familiaris)


name: GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Canis familiaris)


name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Canis familiaris)


name: PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Canis familiaris)


name: PTGS1 dimer binds PTGS1 Inhibitors (Canis familiaris)


name: ASA- acetylates PTGS2 (Canis familiaris)


name: PGH2 is isomerised to PGD2 by HPGDS (Canis familiaris)


name: PGH2 is isomerised to PGD2 by PTGDS (Canis familiaris)


name: PTGS2 dimer binds PTGS2 inhibitors (Canis familiaris)


name: PGE2 is converted to PGF2a by CBR1 (Canis familiaris)


name: Arachidonic acid is oxidised to PGG2 by PTGS2 (Canis familiaris)


name: PGH2 is isomerised to PGE2 by PTGES (Canis familiaris)


name: ASA- acetylates PTGS1 (Canis familiaris)


name: Prostaglandin E synthase isomerizes PGH2 to PGE2 (Canis familiaris)


name: SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Bos taurus)


name: SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Bos taurus)


name: CES1,CES2 hydrolyze ASA- to ST (Bos taurus)


name: ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Bos taurus)


name: CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Bos taurus)


name: GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Bos taurus)


name: ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Bos taurus)


name: CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Bos taurus)


name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Bos taurus)


name: PGH2 is isomerised to PGD2 by HPGDS (Bos taurus)


name: PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Bos taurus)


name: PTGS2 dimer binds PTGS2 inhibitors (Bos taurus)


name: PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Bos taurus)


name: PGH2 is isomerised to PGD2 by PTGDS (Bos taurus)


name: Arachidonic acid is oxidised to PGG2 by PTGS2 (Bos taurus)


name: PGE2 is converted to PGF2a by CBR1 (Bos taurus)


name: Prostaglandin E synthase isomerizes PGH2 to PGE2 (Bos taurus)


name: PTGS1 dimer binds PTGS1 Inhibitors (Bos taurus)


name: PGH2 is isomerised to PGE2 by PTGES (Bos taurus)


name: PGH2 is reduced to PGF2a by AKR1C3 (Bos taurus)


name: CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Sus scrofa)


name: SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Sus scrofa)


name: CES1,CES2 hydrolyze ASA- to ST (Sus scrofa)


name: ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Sus scrofa)


name: SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Sus scrofa)


name: CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Sus scrofa)


name: ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Sus scrofa)


name: GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Sus scrofa)


name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Sus scrofa)


name: PGH2 is isomerised to PGE2 by PTGES (Sus scrofa)


name: PGH2 is reduced to PGF2a by AKR1C3 (Sus scrofa)


name: PGH2 is isomerised to PGD2 by HPGDS (Sus scrofa)


name: PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Sus scrofa)


name: PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Sus scrofa)


name: PTGS2 dimer binds PTGS2 inhibitors (Sus scrofa)


name: PTGS1 dimer binds PTGS1 Inhibitors (Sus scrofa)


name: Arachidonic acid is oxidised to PGG2 by PTGS2 (Sus scrofa)


name: PGH2 is isomerised to PGD2 by PTGDS (Sus scrofa)


name: Prostaglandin E synthase isomerizes PGH2 to PGE2 (Sus scrofa)


name: PGE2 is converted to PGF2a by CBR1 (Sus scrofa)


name: CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Danio rerio)


name: CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Danio rerio)


name: SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Danio rerio)


name: ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Danio rerio)


name: ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Danio rerio)


name: CES1,CES2 hydrolyze ASA- to ST (Danio rerio)


name: SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Danio rerio)


name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Danio rerio)


name: PGE2 is converted to PGF2a by CBR1 (Danio rerio)


name: Prostaglandin E synthase isomerizes PGH2 to PGE2 (Danio rerio)


name: PGH2 is isomerised to PGD2 by PTGDS (Danio rerio)


name: PTGS1 dimer binds PTGS1 Inhibitors (Danio rerio)


name: Arachidonic acid is oxidised to PGG2 by PTGS2 (Danio rerio)


name: PGH2 is isomerised to PGE2 by PTGES (Danio rerio)


name: PTGS2 dimer binds PTGS2 inhibitors (Danio rerio)


name: BCHE hydrolyzes ASA- (Xenopus tropicalis)


name: SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Xenopus tropicalis)


name: CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Xenopus tropicalis)


name: ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Xenopus tropicalis)