name: Ca2+ influx into the post-synaptic cell (Rattus norvegicus)


name: Membrane depolarization upon activation of Ca impermeable AMPA receptors (Rattus norvegicus)

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: Unblocking of NMDA receptors, glutamate binding and activation (Canis familiaris)

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: Ca2+ influx into the post-synaptic cell (Canis familiaris)


name: Membrane depolarization upon activation of Ca impermeable AMPA receptors (Canis familiaris)


name: Unblocking of NMDA receptors, glutamate binding and activation (Sus scrofa)


name: Ca2+ influx into the post-synaptic cell (Sus scrofa)


name: Membrane depolarization upon activation of Ca impermeable AMPA receptors (Sus scrofa)


name: Unblocking of NMDA receptors, glutamate binding and activation (Danio rerio)


name: Ca2+ influx into the post-synaptic cell (Danio rerio)


name: Unblocking of NMDA receptors, glutamate binding and activation (Xenopus tropicalis)


name: Ca2+ influx into the post-synaptic cell (Xenopus tropicalis)


name: Unblocking of NMDA receptors, glutamate binding and activation (Gallus gallus)


name: Membrane depolarization upon activation of Ca impermeable AMPA receptors (Gallus gallus)


name: Ca2+ influx into the post-synaptic cell (Gallus gallus)


name: Unblocking of NMDA receptors, glutamate binding and activation (Drosophila melanogaster)


name: Membrane depolarization upon activation of Ca impermeable AMPA receptors (Drosophila melanogaster)


name: Ca2+ influx into the post-synaptic cell (Drosophila melanogaster)


name: Unblocking of NMDA receptors, glutamate binding and activation (Caenorhabditis elegans)


name: Ca2+ influx into the post-synaptic cell (Caenorhabditis elegans)


name: Membrane depolarization upon activation of Ca impermeable AMPA receptors (Caenorhabditis elegans)


name: CaMKII autophosphorylates (Homo sapiens)


name: CaMKII phosphorylates AMPA receptor (Homo sapiens)


name: Calcium binds calmodulin at the synapse (Homo sapiens)


name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)


name: CaMKII binds activated calmodulin (Homo sapiens)


name: Calmodulin binds neurogranin (Homo sapiens)


name: CaMKII binds activated NMDA receptor (Homo sapiens)


name: Activation of AMPK downstream of NMDARs (Homo sapiens)


name: AMPK negatively regulates binding of MAPT to microtubules (Homo sapiens)


name: CAMKK2 phosphorylates AMPK (Homo sapiens)


name: Intrinsic nucleotide exchange on RAS (Bos taurus)


name: RAS:GTP binds PI3K (Bos taurus)


name: RAS:GTP binds RAL GDS proteins (Bos taurus)


name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Bos taurus)


name: RAS GEFs promote RAS nucleotide exchange (Bos taurus)


name: RCE1 cleaves S-Farn proRAS proteins (Bos taurus)


name: Calmodulin dissociates KRAS4B from the plasma membrane (Bos taurus)


name: KRAS4B is phosphorylated on serine 181 (Bos taurus)


name: USP17L2 deubiquitinates RCE1 (Bos taurus)


name: ARL2:GTP bind PDE6D on KRAS4B (Bos taurus)


name: pro-RAS proteins are farnesylated (Bos taurus)


name: S-Farn-Me KRAS4B binds calmodulin (Bos taurus)


name: Mature S-Farn-Me KRAS4B translocates to plasma membrane (Bos taurus)


name: PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Bos taurus)


name: KRAS4B recycles to the plasma membrane (Bos taurus)


name: ICMT methylates S-Farn RAS proteins (Bos taurus)


name: pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Bos taurus)


name: mature RAS proteins translocate to plasma membrane (Bos taurus)


name: Palmostatin B binds RAS depalmitoylases (Bos taurus)


name: pS181-S-Farn-Me KRAS4B binds BCL2L1 (Bos taurus)


name: RAS proteins are depalmitoylated (Bos taurus)


name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Bos taurus)


name: FNTB inhibitors bind FNTA:FNTB (Bos taurus)


name: Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)


name: Interleukin-3 receptor alpha subunit binds Interleukin-3 (Bos taurus)


name: Interleukin-5 is a homodimer (Bos taurus)


name: Interleukin-5 receptor alpha subunit binds Interleukin-5 (Bos taurus)


name: IL3RB is phosphorylated on Ser-585 (Bos taurus)


name: p-S585-IL3RB binds 14-3-3 proteins (Bos taurus)


name: Recruitment of SHC1 is mediated by Y593 of the common beta chain (Bos taurus)


name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Bos taurus)


name: p-STAT5 dissociates from the receptor complex (Bos taurus)


name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Bos taurus)


name: Activation of STAT5a/b by JAK2 (Bos taurus)


name: 14-3-3 zeta binding allows recruitment of PI3K (Bos taurus)


name: SHP1 and SHP2 bind the common beta chain (Bos taurus)


name: JAK2 is phosphorylated, activated (Bos taurus)


name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Bos taurus)


name: IL3 stimulation induces Vav binding to Tec kinase (Bos taurus)


name: Tyrosine kinases phosphorylate the receptor (Bos taurus)


name: Regulation of signaling by CBL (Bos taurus)


name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)


name: CBL:CRKL binds RAPGEF1 (Bos taurus)


name: Regulation of signaling by CBL (Homo sapiens)


name: CBL binds B-cell linker protein (Homo sapiens)


name: CBL is tyrosine phosphorylated (Homo sapiens)


name: CBL:CRKL binds RAPGEF1 (Homo sapiens)


name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)


name: Regulation of signaling by CBL (Mus musculus)


name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Mus musculus)


name: CBL:CRKL binds RAPGEF1 (Mus musculus)


name: Regulation of signaling by CBL (Rattus norvegicus)


name: CBL ubiquitinates PI3K (Rattus norvegicus)


name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Rattus norvegicus)


name: CBL:CRKL binds RAPGEF1 (Rattus norvegicus)


name: Regulation of signaling by CBL (Canis familiaris)


name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)


name: CBL ubiquitinates PI3K (Canis familiaris)


name: CBL:CRKL binds RAPGEF1 (Canis familiaris)


name: Regulation of signaling by CBL (Sus scrofa)


name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Sus scrofa)


name: CBL:CRKL binds RAPGEF1 (Sus scrofa)


name: Regulation of signaling by CBL (Danio rerio)


name: CBL:CRKL binds RAPGEF1 (Danio rerio)


name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)


name: Regulation of signaling by CBL (Xenopus tropicalis)


name: CBL ubiquitinates PI3K (Xenopus tropicalis)


name: Regulation of signaling by CBL (Gallus gallus)


name: CBL:CRKL binds RAPGEF1 (Gallus gallus)


name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Gallus gallus)


name: Regulation of signaling by CBL (Drosophila melanogaster)


name: CBL:CRKL binds RAPGEF1 (Drosophila melanogaster)


name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Drosophila melanogaster)


name: CBL ubiquitinates PI3K (Drosophila melanogaster)


name: Regulation of signaling by CBL (Caenorhabditis elegans)


name: CBL ubiquitinates PI3K (Caenorhabditis elegans)


name: CBL:CRKL binds RAPGEF1 (Caenorhabditis elegans)


name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Caenorhabditis elegans)


name: Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)


name: The receptor is activated (Homo sapiens)


name: 14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)


name: The common beta chain IL3RB binds JAK2 (Homo sapiens)


name: p-STAT5 dissociates from the receptor complex (Homo sapiens)


name: GM-CSF receptor alpha:GM-CSF binds Bc (Homo sapiens)


name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Homo sapiens)


name: Interleukin-3 receptor alpha subunit binds Interleukin-3 (Homo sapiens)


name: GM-CSF receptor alpha subunit binds GM-CSF (Homo sapiens)


name: IL3RB is phosphorylated on Ser-585 (Homo sapiens)


name: IL3 stimulation induces Vav binding to Tec kinase (Homo sapiens)


name: SHP1 and SHP2 bind the common beta chain (Homo sapiens)


name: Activation of STAT5a/b by JAK2 (Homo sapiens)


name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Homo sapiens)


name: Interleukin-5 is a homodimer (Homo sapiens)


name: JAK2 is phosphorylated, activated (Homo sapiens)


name: Tyrosine kinases phosphorylate the receptor (Homo sapiens)


name: Recruitment of SHC1 is mediated by Y593 of the common beta chain (Homo sapiens)


name: STAT5 is recruited by JAK2 (Homo sapiens)


name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated (Homo sapiens)


name: p-S585-IL3RB binds 14-3-3 proteins (Homo sapiens)


name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)


name: Interleukin-5 receptor alpha subunit binds Interleukin-5 (Homo sapiens)


name: Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)


name: Recruitment of SHC1 is mediated by Y593 of the common beta chain (Mus musculus)


name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Mus musculus)


name: Activation of STAT5a/b by JAK2 (Mus musculus)


name: The receptor is activated (Mus musculus)


name: 14-3-3 zeta binding allows recruitment of PI3K (Mus musculus)


name: p-STAT5 dissociates from the receptor complex (Mus musculus)


name: JAK2 is phosphorylated, activated (Mus musculus)


name: p-S585-IL3RB binds 14-3-3 proteins (Mus musculus)


name: STAT5 is recruited by JAK2 (Mus musculus)


name: SHP1 and SHP2 bind the common beta chain (Mus musculus)


name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Mus musculus)


name: Interleukin-5 is a homodimer (Mus musculus)


name: IL3RB is phosphorylated on Ser-585 (Mus musculus)


name: Interleukin-5 receptor alpha subunit binds Interleukin-5 (Mus musculus)


name: IL3 stimulation induces Vav binding to Tec kinase (Mus musculus)


name: Tyrosine kinases phosphorylate the receptor (Mus musculus)


name: Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)


name: JAK2 is phosphorylated, activated (Rattus norvegicus)


name: Interleukin-3 receptor alpha subunit binds Interleukin-3 (Rattus norvegicus)


name: The receptor is activated (Rattus norvegicus)


name: Activation of STAT5a/b by JAK2 (Rattus norvegicus)


name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Rattus norvegicus)


name: Recruitment of SHC1 is mediated by Y593 of the common beta chain (Rattus norvegicus)


name: p-STAT5 dissociates from the receptor complex (Rattus norvegicus)


name: IL3 stimulation induces Vav binding to Tec kinase (Rattus norvegicus)


name: Tyrosine kinases phosphorylate the receptor (Rattus norvegicus)


name: SHP1 and SHP2 bind the common beta chain (Rattus norvegicus)


name: IL3RB is phosphorylated on Ser-585 (Rattus norvegicus)


name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Rattus norvegicus)


name: Interleukin-5 is a homodimer (Rattus norvegicus)


name: STAT5 is recruited by JAK2 (Rattus norvegicus)


name: p-S585-IL3RB binds 14-3-3 proteins (Rattus norvegicus)


name: 14-3-3 zeta binding allows recruitment of PI3K (Rattus norvegicus)


name: Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)


name: Interleukin-5 receptor alpha subunit binds Interleukin-5 (Canis familiaris)


name: p-S585-IL3RB binds 14-3-3 proteins (Canis familiaris)


name: Interleukin-5 is a homodimer (Canis familiaris)


name: IL3RB is phosphorylated on Ser-585 (Canis familiaris)


name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Canis familiaris)


name: GM-CSF receptor alpha:GM-CSF binds Bc (Canis familiaris)


name: SHP1 and SHP2 bind the common beta chain (Canis familiaris)


name: GM-CSF receptor alpha subunit binds GM-CSF (Canis familiaris)


name: 14-3-3 zeta binding allows recruitment of PI3K (Canis familiaris)


name: The receptor is activated (Canis familiaris)


name: STAT5 is recruited by JAK2 (Canis familiaris)


name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Canis familiaris)


name: Recruitment of SHC1 is mediated by Y593 of the common beta chain (Canis familiaris)


name: Activation of STAT5a/b by JAK2 (Canis familiaris)


name: IL3 stimulation induces Vav binding to Tec kinase (Canis familiaris)


name: Tyrosine kinases phosphorylate the receptor (Canis familiaris)


name: JAK2 is phosphorylated, activated (Canis familiaris)


name: p-STAT5 dissociates from the receptor complex (Canis familiaris)


name: Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)


name: Recruitment of SHC1 is mediated by Y593 of the common beta chain (Sus scrofa)


name: p-STAT5 dissociates from the receptor complex (Sus scrofa)


name: GM-CSF receptor alpha subunit binds GM-CSF (Sus scrofa)


name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Sus scrofa)


name: Activation of STAT5a/b by JAK2 (Sus scrofa)


name: GM-CSF receptor alpha:GM-CSF binds Bc (Sus scrofa)


name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Sus scrofa)


name: JAK2 is phosphorylated, activated (Sus scrofa)


name: 14-3-3 zeta binding allows recruitment of PI3K (Sus scrofa)


name: IL3 stimulation induces Vav binding to Tec kinase (Sus scrofa)


name: Tyrosine kinases phosphorylate the receptor (Sus scrofa)


name: Interleukin-5 is a homodimer (Sus scrofa)


name: IL3RB is phosphorylated on Ser-585 (Sus scrofa)


name: Interleukin-5 receptor alpha subunit binds Interleukin-5 (Sus scrofa)


name: p-S585-IL3RB binds 14-3-3 proteins (Sus scrofa)


name: SHP1 and SHP2 bind the common beta chain (Sus scrofa)


name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Sus scrofa)


name: Intrinsic nucleotide exchange on RAS (Sus scrofa)


name: RAS GEFs promote RAS nucleotide exchange (Sus scrofa)


name: RAS:GTP binds PI3K (Sus scrofa)


name: RAS:GTP binds RAL GDS proteins (Sus scrofa)


name: mature RAS proteins translocate to plasma membrane (Sus scrofa)


name: Calmodulin dissociates KRAS4B from the plasma membrane (Sus scrofa)


name: KRAS4B is phosphorylated on serine 181 (Sus scrofa)


name: RAS proteins are depalmitoylated (Sus scrofa)


name: ARL2:GTP bind PDE6D on KRAS4B (Sus scrofa)


name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Sus scrofa)


name: USP17L2 deubiquitinates RCE1 (Sus scrofa)


name: S-Farn-Me KRAS4B binds calmodulin (Sus scrofa)


name: RCE1 cleaves S-Farn proRAS proteins (Sus scrofa)


name: PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Sus scrofa)


name: Mature S-Farn-Me KRAS4B translocates to plasma membrane (Sus scrofa)


name: KRAS4B recycles to the plasma membrane (Sus scrofa)


name: pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Sus scrofa)


name: pS181-S-Farn-Me KRAS4B binds BCL2L1 (Sus scrofa)


name: Palmostatin B binds RAS depalmitoylases (Sus scrofa)


name: Interaction of DAP12 and CLM7 (Sus scrofa)


name: Interaction of DAP12 and TREM1 (Sus scrofa)


name: Interaction of DAP12 and KIR2DS2 (Sus scrofa)


name: Interaction of DAP12 and KIR2DS5 (Sus scrofa)


name: Interaction of DAP12 and KIR2DS4 (Sus scrofa)


name: Interaction of SIGLEC14/15/16 and DAP12 (Sus scrofa)


name: Interaction of DAP12 and MDL-1 (Sus scrofa)


name: Interaction of DAP12 and KIR3DS1 (Sus scrofa)


name: Interaction of DAP12 and KIR2DS1 (Sus scrofa)


name: Interaction of DAP12 and TREM2 (Sus scrofa)


name: Interaction of DAP12 and NKp44 (Sus scrofa)


name: Phosphorylation of BTK by p-SYK (Sus scrofa)


name: Recruitment of SYK to p-DAP12 (Sus scrofa)


name: Recruitment of GADS:SLP-76 to p-5Y-LAT (Sus scrofa)


name: Activation of RAC1 by VAV2/3 (Sus scrofa)


name: Phosphorylation of SLP-76 by p-SYK (Sus scrofa)


name: Phosphorylation and activation of VAV2/VAV3 by SYK (Sus scrofa)


name: SOS mediated nucleotide exchange of RAS (SHC) (Sus scrofa)


name: Recruitment of GRB2:SOS to p-5Y-LAT (Sus scrofa)


name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Sus scrofa)


name: PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)


name: Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)


name: Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)


name: p85 regulatory unit of PI3K binds p-6Y-SYK (Sus scrofa)


name: Phosphorylation of LAT by p-SYK (Sus scrofa)


name: Phosphorylation of BTK by p-SYK (Homo sapiens)


name: Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)


name: Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)


name: PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)


name: Recruitment of VAV and BTK to p-SLP-76 (Homo sapiens)


name: p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)


name: Recruitment of SYK to p-DAP12 (Homo sapiens)


name: Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)


name: Recruitment of GADS:SLP-76 to p-5Y-LAT (Homo sapiens)


name: Phosphorylation of SLP-76 by p-SYK (Homo sapiens)


name: Activation of RAC1 by VAV2/3 (Homo sapiens)


name: SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)


name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Homo sapiens)


name: Phosphorylation of LAT by p-SYK (Homo sapiens)


name: Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)


name: Recruitment of GADS:SLP-76 to p-5Y-LAT (Mus musculus)


name: Phosphorylation of PLC-gamma by p-BTK/p-SYK (Mus musculus)


name: PI3K phosphorylates PIP2 to PIP3 (Mus musculus)


name: Phosphorylation of SLP-76 by p-SYK (Mus musculus)


name: Phosphorylation of BTK by p-SYK (Mus musculus)


name: p85 regulatory unit of PI3K binds p-6Y-SYK (Mus musculus)


name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Mus musculus)


name: Recruitment of GRB2:SOS to p-5Y-LAT (Mus musculus)


name: Recruitment of SYK to p-DAP12 (Mus musculus)


name: Phosphorylation of LAT by p-SYK (Mus musculus)


name: Phosphorylation and activation of VAV2/VAV3 by SYK (Mus musculus)


name: SOS mediated nucleotide exchange of RAS (SHC) (Mus musculus)


name: Activation of RAC1 by VAV2/3 (Mus musculus)


name: Recruitment of GADS:SLP-76 to p-5Y-LAT (Rattus norvegicus)


name: Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)


name: SOS mediated nucleotide exchange of RAS (SHC) (Rattus norvegicus)


name: Activation of RAC1 by VAV2/3 (Rattus norvegicus)


name: Recruitment of VAV and BTK to p-SLP-76 (Rattus norvegicus)


name: Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)


name: Recruitment of SYK to p-DAP12 (Rattus norvegicus)


name: PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)


name: Phosphorylation of PLC-gamma by p-BTK/p-SYK (Rattus norvegicus)


name: Phosphorylation of BTK by p-SYK (Rattus norvegicus)


name: Phosphorylation of SYK (Rattus norvegicus)


name: Phosphorylation of LAT by p-SYK (Rattus norvegicus)


name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Rattus norvegicus)


name: p85 regulatory unit of PI3K binds p-6Y-SYK (Rattus norvegicus)


name: Recruitment of GRB2:SOS to p-5Y-LAT (Rattus norvegicus)


name: SOS mediated nucleotide exchange of RAS (SHC) (Canis familiaris)


name: Phosphorylation and activation of VAV2/VAV3 by SYK (Canis familiaris)


name: Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)


name: Activation of RAC1 by VAV2/3 (Canis familiaris)


name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Canis familiaris)


name: Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)


name: Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)


name: Phosphorylation of LAT by p-SYK (Canis familiaris)


name: PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)


name: Phosphorylation of SYK (Canis familiaris)


name: Recruitment of GADS:SLP-76 to p-5Y-LAT (Canis familiaris)


name: Phosphorylation of BTK by p-SYK (Canis familiaris)


name: Recruitment of SYK to p-DAP12 (Canis familiaris)


name: p85 regulatory unit of PI3K binds p-6Y-SYK (Canis familiaris)


name: Phosphorylation of SLP-76 by p-SYK (Canis familiaris)


name: Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)


name: Recruitment of GRB2:SOS to p-5Y-LAT (Bos taurus)


name: PI3K phosphorylates PIP2 to PIP3 (Bos taurus)


name: Activation of RAC1 by VAV2/3 (Bos taurus)


name: SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)


name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Bos taurus)


name: Recruitment of GADS:SLP-76 to p-5Y-LAT (Bos taurus)


name: Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)


name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Xenopus tropicalis)


name: SOS mediated nucleotide exchange of RAS (SHC) (Xenopus tropicalis)


name: Activation of RAC1 by VAV2/3 (Xenopus tropicalis)


name: Recruitment of GADS:SLP-76 to p-5Y-LAT (Xenopus tropicalis)


name: Phosphorylation of PLC-gamma by p-BTK/p-SYK (Xenopus tropicalis)


name: Recruitment of VAV and BTK to p-SLP-76 (Xenopus tropicalis)


name: Phosphorylation of BTK by p-SYK (Gallus gallus)


name: Recruitment of SYK to p-DAP12 (Gallus gallus)


name: Recruitment of VAV and BTK to p-SLP-76 (Gallus gallus)


name: p85 regulatory unit of PI3K binds p-6Y-SYK (Gallus gallus)


name: Phosphorylation of SLP-76 by p-SYK (Gallus gallus)


name: PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)


name: Phosphorylation of PLC-gamma by p-BTK/p-SYK (Gallus gallus)


name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Gallus gallus)


name: Activation of RAC1 by VAV2/3 (Gallus gallus)


name: Phosphorylation and activation of VAV2/VAV3 by SYK (Gallus gallus)


name: SOS mediated nucleotide exchange of RAS (SHC) (Gallus gallus)


name: Recruitment of GADS:SLP-76 to p-5Y-LAT (Gallus gallus)


name: DAP12 signaling (Drosophila melanogaster)


name: Recruitment of VAV and BTK to p-SLP-76 (Drosophila melanogaster)


name: Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)


name: Recruitment of GADS:SLP-76 to p-5Y-LAT (Drosophila melanogaster)


name: Release of p-PLCG1 (Drosophila melanogaster)


name: SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)


name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)


name: Activation of RAC1 by VAV2/3 (Drosophila melanogaster)


name: DAG stimulates protein kinase C-delta (Sus scrofa)


name: CaMK IV-mediated phosphorylation of CREB (Sus scrofa)


name: CaMK IV-mediated phosphorylation of CREB (Homo sapiens)


name: Dimerization of p-S133-CREB1 (Homo sapiens)


name: CaMK IV-mediated phosphorylation of CREB (Mus musculus)


name: CaMK IV-mediated phosphorylation of CREB (Rattus norvegicus)


name: CaMK IV-mediated phosphorylation of CREB (Canis familiaris)


name: CaMK IV-mediated phosphorylation of CREB (Bos taurus)


name: CaMK IV-mediated phosphorylation of CREB (Gallus gallus)


name: CaMK IV-mediated phosphorylation of CREB (Drosophila melanogaster)


name: CaMK IV-mediated phosphorylation of CREB (Caenorhabditis elegans)


name: CaMK IV-mediated phosphorylation of CREB (Dictyostelium discoideum)


name: CaMK IV-mediated phosphorylation of CREB (Schizosaccharomyces pombe)


name: CaMK IV-mediated phosphorylation of CREB (Plasmodium falciparum)


name: Adenylate cyclase produces cAMP (Sus scrofa)


name: Adenylate cyclase produces cAMP (Homo sapiens)


name: Adenylate cyclase produces cAMP (Mus musculus)


name: Adenylate cyclase produces cAMP (Rattus norvegicus)


name: Adenylate cyclase produces cAMP (Canis familiaris)


name: Adenylate cyclase produces cAMP (Bos taurus)


name: Adenylate cyclase produces cAMP (Danio rerio)


name: Adenylate cyclase produces cAMP (Xenopus tropicalis)


name: Adenylate cyclase produces cAMP (Gallus gallus)


name: PKA activation (Drosophila melanogaster)


name: Adenylate cyclase produces cAMP (Drosophila melanogaster)


name: Adenylate cyclase produces cAMP (Caenorhabditis elegans)


name: PKA activation (Dictyostelium discoideum)


name: Adenylate cyclase produces cAMP (Dictyostelium discoideum)


name: PKA activation (Schizosaccharomyces pombe)


name: PKA activation (Saccharomyces cerevisiae)


name: PKA-mediated phosphorylation of CREB (Homo sapiens)


name: cAMP hydrolysis by Cam-PDE 1 (Sus scrofa)


name: Calmodulin activates Cam-PDE 1 (Sus scrofa)


name: Calmodulin activates Cam-PDE 1 (Homo sapiens)


name: calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity

description: Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin.


name: cAMP hydrolysis by Cam-PDE 1 (Mus musculus)


name: Calmodulin activates Cam-PDE 1 (Mus musculus)


name: Cam-PDE 1 activation (Rattus norvegicus)


name: cAMP hydrolysis by Cam-PDE 1 (Rattus norvegicus)


name: Calmodulin activates Cam-PDE 1 (Rattus norvegicus)


name: cAMP hydrolysis by Cam-PDE 1 (Canis familiaris)


name: Calmodulin activates Cam-PDE 1 (Canis familiaris)


name: cAMP hydrolysis by Cam-PDE 1 (Bos taurus)


name: Calmodulin activates Cam-PDE 1 (Bos taurus)


name: Cam-PDE 1 activation (Xenopus tropicalis)


name: Calmodulin activates Cam-PDE 1 (Xenopus tropicalis)


name: cAMP hydrolysis by Cam-PDE 1 (Xenopus tropicalis)


name: Calmodulin activates Cam-PDE 1 (Gallus gallus)


name: cAMP hydrolysis by Cam-PDE 1 (Gallus gallus)


name: Cam-PDE 1 activation (Drosophila melanogaster)


name: cAMP hydrolysis by Cam-PDE 1 (Drosophila melanogaster)


name: Calmodulin activates Cam-PDE 1 (Drosophila melanogaster)


name: Cam-PDE 1 activation (Caenorhabditis elegans)


name: Calmodulin activates Cam-PDE 1 (Caenorhabditis elegans)


name: cAMP hydrolysis by Cam-PDE 1 (Caenorhabditis elegans)


name: Cam-PDE 1 activation (Dictyostelium discoideum)


name: cAMP hydrolysis by Cam-PDE 1 (Dictyostelium discoideum)


name: Calmodulin activates Cam-PDE 1 (Dictyostelium discoideum)


name: Cam-PDE 1 activation (Plasmodium falciparum)


name: cAMP hydrolysis by Cam-PDE 1 (Plasmodium falciparum)


name: Calmodulin activates Cam-PDE 1 (Plasmodium falciparum)


name: Calmodulin induced events (Homo sapiens)


name: Calmodulin induced events (Mus musculus)


name: Calmodulin induced events (Rattus norvegicus)


name: PKC phosphorylates GRK2 (Rattus norvegicus)


name: GRK2 binds CALM1:4Ca2+ (Rattus norvegicus)


name: Calmodulin induced events (Canis familiaris)


name: GRK2 binds CALM1:4Ca2+ (Canis familiaris)


name: PKC phosphorylates GRK2 (Canis familiaris)


name: Calmodulin induced events (Xenopus tropicalis)


name: PKC phosphorylates GRK2 (Xenopus tropicalis)


name: Calmodulin induced events (Gallus gallus)


name: Calmodulin induced events (Drosophila melanogaster)


name: GRK2 binds CALM1:4Ca2+ (Drosophila melanogaster)


name: PKC phosphorylates GRK2 (Drosophila melanogaster)


name: Calmodulin induced events (Caenorhabditis elegans)


name: GRK2 binds CALM1:4Ca2+ (Caenorhabditis elegans)


name: PKC phosphorylates GRK2 (Caenorhabditis elegans)


name: DAG stimulates protein kinase C-delta (Homo sapiens)


name: Active PLCG1 hydrolyses PIP2 (Homo sapiens)


name: DAG stimulates protein kinase C-delta (Mus musculus)


name: DAG and IP3 signaling (Rattus norvegicus)


name: DAG stimulates protein kinase C-delta (Rattus norvegicus)


name: DAG and IP3 signaling (Canis familiaris)


name: DAG stimulates protein kinase C-delta (Canis familiaris)


name: DAG stimulates protein kinase C-delta (Bos taurus)


name: DAG stimulates protein kinase C-delta (Danio rerio)


name: DAG and IP3 signaling (Xenopus tropicalis)


name: DAG stimulates protein kinase C-delta (Xenopus tropicalis)


name: DAG stimulates protein kinase C-delta (Gallus gallus)


name: DAG and IP3 signaling (Drosophila melanogaster)


name: DAG stimulates protein kinase C-delta (Drosophila melanogaster)


name: DAG and IP3 signaling (Caenorhabditis elegans)


name: DAG stimulates protein kinase C-delta (Caenorhabditis elegans)


name: DAG and IP3 signaling (Dictyostelium discoideum)


name: DAG stimulates protein kinase C-delta (Dictyostelium discoideum)


name: DAG and IP3 signaling (Schizosaccharomyces pombe)


name: DAG stimulates protein kinase C-delta (Schizosaccharomyces pombe)


name: DAG and IP3 signaling (Saccharomyces cerevisiae)


name: DAG stimulates protein kinase C-delta (Saccharomyces cerevisiae)


name: PIP3 activates AKT signaling (Sus scrofa)


name: TORC2 complex phosphorylates SGK1 (Sus scrofa)


name: RAC1,RAC2,RHOG activate PI3K (Sus scrofa)


name: Extra-nuclear estrogen signaling (Sus scrofa)


name: Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Sus scrofa)


name: Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Sus scrofa)


name: ESR-associated SRC autophosphorylates (Sus scrofa)


name: Estrogen stimulates dimerization of plasma membrane estrogen receptors (Sus scrofa)


name: ZDHHC7, ZDHHC21 palmitoylate ESR1 (Sus scrofa)


name: S1P binds S1PR3 in response to E2 stimulation (Sus scrofa)


name: SPHK1 phosphorylates sphingosine in response to E2 stimulation (Sus scrofa)


name: PI3K binds membrane-associated estrogen receptors (Sus scrofa)


name: PalmS-ESRs:CAVs translocate to plasma membrane (Sus scrofa)


name: Membrane estrogen receptors bind SRC (Sus scrofa)


name: G-proteins dissociate from plasma-membrane estrogen receptors (Sus scrofa)


name: Estrogen-stimulated signaling through PRKCZ (Sus scrofa)


name: PRKCZ autophosphorylates downstream of estrogen stimulation (Sus scrofa)


name: PRKCZ recruits RAS in response to estrogen stimulation (Sus scrofa)


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Sus scrofa)


name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Sus scrofa)


name: Estrogen-stimulated signaling through PRKCZ (Homo sapiens)


name: 3-phosphoinositide-dependent protein kinase activity

description: Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Homo sapiens)


name: PRKCZ recruits RAS in response to estrogen stimulation (Homo sapiens)


name: PRKCZ autophosphorylates downstream of estrogen stimulation (Homo sapiens)


name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Homo sapiens)


name: Estrogen-stimulated signaling through PRKCZ (Mus musculus)


name: PRKCZ autophosphorylates downstream of estrogen stimulation (Mus musculus)


name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Mus musculus)


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Mus musculus)


name: PRKCZ recruits RAS in response to estrogen stimulation (Mus musculus)


name: Estrogen-stimulated signaling through PRKCZ (Rattus norvegicus)


name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Rattus norvegicus)


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Rattus norvegicus)


name: PRKCZ recruits RAS in response to estrogen stimulation (Rattus norvegicus)


name: PRKCZ autophosphorylates downstream of estrogen stimulation (Rattus norvegicus)


name: Estrogen-stimulated signaling through PRKCZ (Canis familiaris)


name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Canis familiaris)


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Canis familiaris)


name: PRKCZ autophosphorylates downstream of estrogen stimulation (Canis familiaris)


name: PRKCZ recruits RAS in response to estrogen stimulation (Canis familiaris)


name: Estrogen-stimulated signaling through PRKCZ (Bos taurus)


name: PRKCZ recruits RAS in response to estrogen stimulation (Bos taurus)


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Bos taurus)


name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Bos taurus)


name: PRKCZ autophosphorylates downstream of estrogen stimulation (Bos taurus)


name: Estrogen-stimulated signaling through PRKCZ (Danio rerio)


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Danio rerio)


name: Estrogen-stimulated signaling through PRKCZ (Xenopus tropicalis)


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Xenopus tropicalis)


name: Estrogen-stimulated signaling through PRKCZ (Gallus gallus)


name: PRKCZ autophosphorylates downstream of estrogen stimulation (Gallus gallus)


name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Gallus gallus)


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Gallus gallus)


name: PRKCZ recruits RAS in response to estrogen stimulation (Gallus gallus)


name: Estrogen-stimulated signaling through PRKCZ (Drosophila melanogaster)


name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Drosophila melanogaster)


name: PRKCZ recruits RAS in response to estrogen stimulation (Drosophila melanogaster)


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Drosophila melanogaster)


name: PRKCZ autophosphorylates downstream of estrogen stimulation (Drosophila melanogaster)


name: Estrogen-stimulated signaling through PRKCZ (Caenorhabditis elegans)


name: PRKCZ recruits RAS in response to estrogen stimulation (Caenorhabditis elegans)


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Caenorhabditis elegans)


name: PRKCZ autophosphorylates downstream of estrogen stimulation (Caenorhabditis elegans)


name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Caenorhabditis elegans)


name: Estrogen-stimulated signaling through PRKCZ (Dictyostelium discoideum)


name: PRKCZ autophosphorylates downstream of estrogen stimulation (Dictyostelium discoideum)


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Dictyostelium discoideum)


name: Estrogen-stimulated signaling through PRKCZ (Schizosaccharomyces pombe)


name: PRKCZ autophosphorylates downstream of estrogen stimulation (Schizosaccharomyces pombe)


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Schizosaccharomyces pombe)


name: Estrogen-stimulated signaling through PRKCZ (Saccharomyces cerevisiae)


name: PRKCZ autophosphorylates downstream of estrogen stimulation (Saccharomyces cerevisiae)


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Saccharomyces cerevisiae)


name: Estrogen-stimulated signaling through PRKCZ (Plasmodium falciparum)


name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Plasmodium falciparum)


name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Sus scrofa)


name: p-S10 CDKN1B translocates to the cytosol (Sus scrofa)


name: AKT-phosphorylated FOXO3 translocates to cytosol (Sus scrofa)


name: CDKN1B is phosphorylated in response to estrogen (Sus scrofa)


name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Homo sapiens)


name: p-S133 CREB1 dimer binds the CCND1 promoter (Homo sapiens)


name: AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)


name: BCL gene expression downstream of ESR1 (Homo sapiens)


name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Homo sapiens)


name: p-S10 CDKN1B translocates to the cytosol (Homo sapiens)


name: E2-mediated FOS gene expression (Homo sapiens)


name: ESR1-dependent CCND1 expression (Homo sapiens)


name: CDKN1B is phosphorylated in response to estrogen (Homo sapiens)


name: SRF and ELK1 bind the FOS gene (Homo sapiens)


name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Mus musculus)


name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Mus musculus)


name: p-S10 CDKN1B translocates to the cytosol (Mus musculus)


name: CDKN1B is phosphorylated in response to estrogen (Mus musculus)


name: AKT-phosphorylated FOXO3 translocates to cytosol (Mus musculus)


name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Rattus norvegicus)


name: AKT-phosphorylated FOXO3 translocates to cytosol (Rattus norvegicus)


name: CDKN1B is phosphorylated in response to estrogen (Rattus norvegicus)


name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Rattus norvegicus)


name: p-S10 CDKN1B translocates to the cytosol (Rattus norvegicus)


name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Canis familiaris)


name: AKT-phosphorylated FOXO3 translocates to cytosol (Canis familiaris)


name: CDKN1B is phosphorylated in response to estrogen (Canis familiaris)


name: p-S10 CDKN1B translocates to the cytosol (Canis familiaris)


name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Bos taurus)


name: AKT-phosphorylated FOXO3 translocates to cytosol (Bos taurus)


name: CDKN1B is phosphorylated in response to estrogen (Bos taurus)


name: p-S10 CDKN1B translocates to the cytosol (Bos taurus)


name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Danio rerio)


name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Danio rerio)


name: CDKN1B is phosphorylated in response to estrogen (Danio rerio)


name: p-S10 CDKN1B translocates to the cytosol (Danio rerio)


name: AKT-phosphorylated FOXO3 translocates to cytosol (Danio rerio)


name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Xenopus tropicalis)


name: AKT-phosphorylated FOXO3 translocates to cytosol (Xenopus tropicalis)


name: p-S10 CDKN1B translocates to the cytosol (Xenopus tropicalis)


name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Gallus gallus)


name: p-S10 CDKN1B translocates to the cytosol (Gallus gallus)


name: CDKN1B is phosphorylated in response to estrogen (Gallus gallus)


name: AKT-phosphorylated FOXO3 translocates to cytosol (Gallus gallus)


name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Gallus gallus)


name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Drosophila melanogaster)


name: p-S10 CDKN1B translocates to the cytosol (Drosophila melanogaster)


name: AKT-phosphorylated FOXO3 translocates to cytosol (Drosophila melanogaster)


name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Drosophila melanogaster)


name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Caenorhabditis elegans)


name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Caenorhabditis elegans)


name: AKT-phosphorylated FOXO3 translocates to cytosol (Caenorhabditis elegans)


name: p-S10 CDKN1B translocates to the cytosol (Caenorhabditis elegans)


name: Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Sus scrofa)


name: eNOS:Caveolin-1 complex binds to CaM (Sus scrofa)


name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Sus scrofa)


name: BH2 binding can lead to eNOS uncoupling (Sus scrofa)


name: Uncoupled eNOS favours the formation of superoxide (Sus scrofa)


name: HSP90 binds eNOS:Caveolin-1:CaM complex (Sus scrofa)


name: eNOS translocation from Golgi to Caveolae (Sus scrofa)


name: eNOS associates with Caveolin-1 (Sus scrofa)


name: Salvage - Sepiapterin is reduced to BH2 (Sus scrofa)


name: depalmitoylated eNOS translocates from plasma membrane (Sus scrofa)


name: eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)


name: Salvage - Sepiapterin is reduced to BH2 (Homo sapiens)


name: AKT1 binds eNOS complex via HSP90 (Homo sapiens)


name: depalmitoylated eNOS translocates from plasma membrane (Homo sapiens)


name: eNOS translocation from Golgi to Caveolae (Homo sapiens)


name: BH2 binding can lead to eNOS uncoupling (Homo sapiens)


name: HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)


name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)


name: DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Homo sapiens)


name: Uncoupled eNOS favours the formation of superoxide (Homo sapiens)


name: Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)


name: eNOS associates with Caveolin-1 (Homo sapiens)


name: Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-) (Homo sapiens)


name: Uncoupled eNOS favours the formation of superoxide (Mus musculus)


name: Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Mus musculus)


name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)


name: BH2 binding can lead to eNOS uncoupling (Mus musculus)


name: eNOS translocation from Golgi to Caveolae (Mus musculus)


name: depalmitoylated eNOS translocates from plasma membrane (Mus musculus)


name: eNOS associates with Caveolin-1 (Mus musculus)


name: AKT1 binds eNOS complex via HSP90 (Mus musculus)


name: Salvage - Sepiapterin is reduced to BH2 (Mus musculus)


name: HSP90 binds eNOS:Caveolin-1:CaM complex (Mus musculus)


name: eNOS:Caveolin-1 complex binds to CaM (Mus musculus)


name: DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Mus musculus)


name: Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Rattus norvegicus)


name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)


name: AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)


name: depalmitoylated eNOS translocates from plasma membrane (Rattus norvegicus)


name: N-myristoylation of eNOS (Rattus norvegicus)


name: CYGB dioxygenates NO (Rattus norvegicus)


name: AKT1 phosphorylates eNOS (Rattus norvegicus)


name: depalmitoylation of eNOS (Rattus norvegicus)


name: Uncoupled eNOS favours the formation of superoxide (Rattus norvegicus)


name: BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)


name: eNOS:Caveolin-1 complex binds to CaM (Rattus norvegicus)


name: HSP90 binds eNOS:Caveolin-1:CaM complex (Rattus norvegicus)


name: eNOS associates with Caveolin-1 (Rattus norvegicus)


name: Salvage - Sepiapterin is reduced to BH2 (Rattus norvegicus)


name: eNOS translocation from Golgi to Caveolae (Rattus norvegicus)


name: DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Rattus norvegicus)


name: palmitoylation of eNOS (Rattus norvegicus)


name: DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Canis familiaris)


name: Salvage - Sepiapterin is reduced to BH2 (Canis familiaris)


name: depalmitoylated eNOS translocates from plasma membrane (Bos taurus)


name: Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Bos taurus)


name: Salvage - Sepiapterin is reduced to BH2 (Bos taurus)


name: DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Bos taurus)


name: eNOS associates with Caveolin-1 (Bos taurus)


name: eNOS translocation from Golgi to Caveolae (Bos taurus)


name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)


name: BH2 binding can lead to eNOS uncoupling (Bos taurus)


name: HSP90 binds eNOS:Caveolin-1:CaM complex (Bos taurus)


name: eNOS:Caveolin-1 complex binds to CaM (Bos taurus)


name: Uncoupled eNOS favours the formation of superoxide (Bos taurus)


name: Salvage - Sepiapterin is reduced to BH2 (Danio rerio)


name: Salvage - Sepiapterin is reduced to BH2 (Xenopus tropicalis)


name: DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Xenopus tropicalis)


name: CYGB dioxygenates NO (Xenopus tropicalis)


name: eNOS:Caveolin-1 complex binds to CaM (Gallus gallus)


name: HSP90 binds eNOS:Caveolin-1:CaM complex (Gallus gallus)


name: AKT1 phosphorylates eNOS (Gallus gallus)


name: Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Gallus gallus)


name: AKT1 binds eNOS complex via HSP90 (Gallus gallus)


name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)


name: eNOS activation (Drosophila melanogaster)


name: depalmitoylation of eNOS (Drosophila melanogaster)


name: eNOS synthesizes NO (Drosophila melanogaster)


name: AKT1 phosphorylates eNOS (Drosophila melanogaster)


name: Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)


name: AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)


name: BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)


name: depalmitoylated eNOS translocates from plasma membrane (Drosophila melanogaster)


name: DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Drosophila melanogaster)


name: eNOS translocation from Golgi to Caveolae (Drosophila melanogaster)


name: Salvage - Sepiapterin is reduced to BH2 (Drosophila melanogaster)


name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)


name: N-myristoylation of eNOS (Drosophila melanogaster)


name: eNOS activation (Caenorhabditis elegans)


name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)


name: BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)


name: AKT1 phosphorylates eNOS (Caenorhabditis elegans)


name: Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)


name: eNOS synthesizes NO (Caenorhabditis elegans)


name: CYGB dioxygenates NO (Caenorhabditis elegans)


name: eNOS activation (Dictyostelium discoideum)


name: BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)


name: Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)


name: eNOS synthesizes NO (Dictyostelium discoideum)


name: palmitoylation of eNOS (Dictyostelium discoideum)


name: eNOS translocation from Golgi to Caveolae (Dictyostelium discoideum)


name: Salvage - Sepiapterin is reduced to BH2 (Dictyostelium discoideum)


name: N-myristoylation of eNOS (Dictyostelium discoideum)


name: depalmitoylation of eNOS (Dictyostelium discoideum)


name: depalmitoylated eNOS translocates from plasma membrane (Dictyostelium discoideum)


name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)


name: AKT1 binds eNOS complex via HSP90 (Dictyostelium discoideum)


name: AKT1 phosphorylates eNOS (Dictyostelium discoideum)


name: eNOS activation (Schizosaccharomyces pombe)


name: BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)


name: depalmitoylated eNOS translocates from plasma membrane (Schizosaccharomyces pombe)


name: AKT1 binds eNOS complex via HSP90 (Schizosaccharomyces pombe)


name: Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)


name: AKT1 phosphorylates eNOS (Schizosaccharomyces pombe)


name: eNOS synthesizes NO (Schizosaccharomyces pombe)


name: N-myristoylation of eNOS (Schizosaccharomyces pombe)


name: depalmitoylation of eNOS (Schizosaccharomyces pombe)


name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)


name: eNOS translocation from Golgi to Caveolae (Schizosaccharomyces pombe)


name: eNOS activation (Saccharomyces cerevisiae)


name: BH2 binding can lead to eNOS uncoupling (Saccharomyces cerevisiae)


name: depalmitoylation of eNOS (Saccharomyces cerevisiae)


name: Uncoupled eNOS favours the formation of superoxide (Saccharomyces cerevisiae)


name: depalmitoylated eNOS translocates from plasma membrane (Saccharomyces cerevisiae)


name: eNOS translocation from Golgi to Caveolae (Saccharomyces cerevisiae)


name: AKT1 phosphorylates eNOS (Saccharomyces cerevisiae)


name: N-myristoylation of eNOS (Saccharomyces cerevisiae)


name: eNOS synthesizes NO (Saccharomyces cerevisiae)


name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Saccharomyces cerevisiae)


name: BH2 binding can lead to eNOS uncoupling (Plasmodium falciparum)


name: eNOS synthesizes NO (Plasmodium falciparum)


name: Uncoupled eNOS favours the formation of superoxide (Plasmodium falciparum)


name: eNOS translocation from Golgi to Caveolae (Plasmodium falciparum)


name: N-myristoylation of eNOS (Plasmodium falciparum)


name: depalmitoylated eNOS translocates from plasma membrane (Plasmodium falciparum)


name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Plasmodium falciparum)


name: AKT1 phosphorylates eNOS (Plasmodium falciparum)


name: NOSTRIN mediated eNOS trafficking (Sus scrofa)


name: NOSTRIN mediated translocation of eNOS from plasma membrane (Sus scrofa)


name: eNOS:Caveolin-1 complex binds to Nostrin (Sus scrofa)


name: eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Sus scrofa)


name: eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Sus scrofa)


name: NOSTRIN mediated eNOS trafficking (Homo sapiens)


name: eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Homo sapiens)


name: eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Homo sapiens)


name: NOSTRIN mediated translocation of eNOS from plasma membrane (Homo sapiens)


name: eNOS:Caveolin-1 complex binds to Nostrin (Homo sapiens)


name: NOSTRIN mediated eNOS trafficking (Mus musculus)


name: NOSTRIN mediated translocation of eNOS from plasma membrane (Mus musculus)


name: eNOS:Caveolin-1 complex binds to Nostrin (Mus musculus)


name: eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Mus musculus)


name: NOSTRIN mediated eNOS trafficking (Rattus norvegicus)


name: eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Rattus norvegicus)


name: eNOS:Caveolin-1 complex binds to Nostrin (Rattus norvegicus)


name: NOSTRIN mediated translocation of eNOS from plasma membrane (Rattus norvegicus)


name: NOSTRIN mediated eNOS trafficking (Canis familiaris)


name: eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)


name: NOSTRIN mediated translocation of eNOS from plasma membrane (Canis familiaris)


name: NOSTRIN mediated eNOS trafficking (Bos taurus)


name: eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Bos taurus)


name: NOSTRIN mediated translocation of eNOS from plasma membrane (Bos taurus)


name: NOSTRIN mediated eNOS trafficking (Danio rerio)


name: NOSTRIN mediated translocation of eNOS from plasma membrane (Danio rerio)


name: eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Danio rerio)


name: NOSIP mediated eNOS trafficking (Sus scrofa)


name: eNOS:NOSIP translocation from caveolae to intracellular compartments (Sus scrofa)


name: NOSIP mediated eNOS trafficking (Homo sapiens)


name: eNOS:NOSIP translocation from caveolae to intracellular compartments (Homo sapiens)


name: NOSIP mediated eNOS trafficking (Mus musculus)


name: eNOS:NOSIP translocation from caveolae to intracellular compartments (Mus musculus)


name: NOSIP mediated eNOS trafficking (Rattus norvegicus)


name: eNOS:NOSIP translocation from caveolae to intracellular compartments (Rattus norvegicus)


name: NOSIP mediated eNOS trafficking (Bos taurus)


name: eNOS:NOSIP translocation from caveolae to intracellular compartments (Bos taurus)


name: NOSIP mediated eNOS trafficking (Drosophila melanogaster)


name: eNOS:NOSIP translocation from caveolae to intracellular compartments (Drosophila melanogaster)


name: eNOS binds NOSIP (Drosophila melanogaster)


name: NOSIP mediated eNOS trafficking (Dictyostelium discoideum)


name: eNOS:NOSIP translocation from caveolae to intracellular compartments (Dictyostelium discoideum)


name: eNOS binds NOSIP (Dictyostelium discoideum)


name: NOSIP mediated eNOS trafficking (Plasmodium falciparum)


name: eNOS:NOSIP translocation from caveolae to intracellular compartments (Plasmodium falciparum)


name: eNOS binds NOSIP (Plasmodium falciparum)


NADPH regeneration

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A metabolic process that generates a pool of NADPH by the reduction of NADP+.


name: ACO1:4Fe-4S isomerises CIT to ISCIT (Sus scrofa)


name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)


name: carboxylic acid transmembrane transporter activity

description: Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).


name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)


name: ACO1:4Fe-4S isomerises CIT to ISCIT (Homo sapiens)


name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)


name: ACO1:4Fe-4S isomerises CIT to ISCIT (Mus musculus)


name: ACO1:4Fe-4S isomerises CIT to ISCIT (Rattus norvegicus)


name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)


name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)


name: ACO1:4Fe-4S isomerises CIT to ISCIT (Canis familiaris)


name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)


name: ACO1:4Fe-4S isomerises CIT to ISCIT (Bos taurus)


name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)


name: ACO1:4Fe-4S isomerises CIT to ISCIT (Danio rerio)


name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Xenopus tropicalis)


name: ACO1:4Fe-4S isomerises CIT to ISCIT (Xenopus tropicalis)


name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)


name: ACO1:4Fe-4S isomerises CIT to ISCIT (Drosophila melanogaster)


name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)


name: ACO1:4Fe-4S isomerises CIT to ISCIT (Caenorhabditis elegans)


name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)


name: ACO1:4Fe-4S isomerises CIT to ISCIT (Dictyostelium discoideum)


name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)


name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)


name: ACO1:4Fe-4S isomerises CIT to ISCIT (Plasmodium falciparum)


name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Sus scrofa)


name: PTPS is phosphorylated by cGMP-dependant protein kinase II (Sus scrofa)


name: DHNTP is dephosphorylated by PTPS to PTHP (Sus scrofa)


name: PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Sus scrofa)


name: Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Sus scrofa)


name: GCH1 reduces GTP to dihydroneopterin triphosphate (Sus scrofa)


name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)


name: DHNTP is dephosphorylated by PTPS to PTHP (Homo sapiens)


name: Peroxynitrite can oxidise BH4 to the BH3 radical (Homo sapiens)


name: GCHFR binds to GCH1 and negatively regulates its activity (Homo sapiens)


name: BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle (Homo sapiens)


name: Salvage - BH2 is reduced to BH4 by DHFR (Homo sapiens)


name: GCH1 reduces GTP to dihydroneopterin triphosphate (Homo sapiens)


name: The BH3 radical can decay to dihydrobiopterin (BH2) (Homo sapiens)


name: Ferrous iron reduces the BH3 radical back to BH4 (Homo sapiens)


name: Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Homo sapiens)


name: Ascorbate can reduce the BH3 radical back to BH4 (Homo sapiens)


name: Unknown sepiapterin synthase transforms PTHP to sepiapterin (Homo sapiens)


name: PTPS is phosphorylated by cGMP-dependant protein kinase II (Homo sapiens)


name: PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Homo sapiens)


name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Mus musculus)


name: DHNTP is dephosphorylated by PTPS to PTHP (Mus musculus)


name: PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Mus musculus)


name: GCH1 reduces GTP to dihydroneopterin triphosphate (Mus musculus)


name: GCHFR binds to GCH1 and negatively regulates its activity (Mus musculus)


name: Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Mus musculus)


name: PTPS is phosphorylated by cGMP-dependant protein kinase II (Mus musculus)


name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Rattus norvegicus)


name: GCHFR binds to GCH1 and negatively regulates its activity (Rattus norvegicus)


name: PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Rattus norvegicus)


name: DHNTP is dephosphorylated by PTPS to PTHP (Rattus norvegicus)


name: GCH1 reduces GTP to dihydroneopterin triphosphate (Rattus norvegicus)


name: Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Rattus norvegicus)


name: PTPS is phosphorylated by cGMP-dependant protein kinase II (Rattus norvegicus)


name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Canis familiaris)


name: GCHFR binds to GCH1 and negatively regulates its activity (Canis familiaris)


name: GCH1 reduces GTP to dihydroneopterin triphosphate (Canis familiaris)


name: Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Canis familiaris)


name: PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Canis familiaris)


name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)


name: Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Bos taurus)


name: DHNTP is dephosphorylated by PTPS to PTHP (Bos taurus)


name: PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Bos taurus)


name: GCH1 reduces GTP to dihydroneopterin triphosphate (Bos taurus)


name: PTPS is phosphorylated by cGMP-dependant protein kinase II (Bos taurus)


name: GCHFR binds to GCH1 and negatively regulates its activity (Bos taurus)


name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Danio rerio)


name: PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Danio rerio)


name: DHNTP is dephosphorylated by PTPS to PTHP (Danio rerio)


name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Xenopus tropicalis)


name: GCHFR binds to GCH1 and negatively regulates its activity (Xenopus tropicalis)


name: PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Xenopus tropicalis)


name: Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Xenopus tropicalis)


name: GCH1 reduces GTP to dihydroneopterin triphosphate (Xenopus tropicalis)


name: DHNTP is dephosphorylated by PTPS to PTHP (Xenopus tropicalis)


name: PTPS is phosphorylated by cGMP-dependant protein kinase II (Xenopus tropicalis)


name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Drosophila melanogaster)


name: PTPS is phosphorylated by cGMP-dependant protein kinase II (Drosophila melanogaster)


name: GCH1 reduces GTP to dihydroneopterin triphosphate (Drosophila melanogaster)


name: Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Drosophila melanogaster)


name: DHNTP is dephosphorylated by PTPS to PTHP (Drosophila melanogaster)


name: PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Drosophila melanogaster)


name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Caenorhabditis elegans)


name: DHNTP is dephosphorylated by PTPS to PTHP (Caenorhabditis elegans)


name: GCHFR binds to GCH1 and negatively regulates its activity (Caenorhabditis elegans)


name: GCH1 reduces GTP to dihydroneopterin triphosphate (Caenorhabditis elegans)


name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Dictyostelium discoideum)


name: DHNTP is dephosphorylated by PTPS to PTHP (Dictyostelium discoideum)


name: GCH1 reduces GTP to dihydroneopterin triphosphate (Dictyostelium discoideum)


name: PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Dictyostelium discoideum)


name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Schizosaccharomyces pombe)


name: GCH1 reduces GTP to dihydroneopterin triphosphate (Schizosaccharomyces pombe)


name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Saccharomyces cerevisiae)


name: GCH1 reduces GTP to dihydroneopterin triphosphate (Saccharomyces cerevisiae)


name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Plasmodium falciparum)


name: DHNTP is dephosphorylated by PTPS to PTHP (Plasmodium falciparum)


name: COQ2 ligates all-E-10PrP2 to PHB (Sus scrofa)


name: STARD7 transports Q10 to plasma membrane (Sus scrofa)


name: PDSS1,2 ligates FPP to IPPP (Sus scrofa)


name: COQ7:COQ9 octamer hydroxylates DMQ10H2 (Sus scrofa)


name: mito-STARD7 transports Q10 to outer mitochondrial membrane (Sus scrofa)


name: mito-STARD7 transports Q10 to outer mitochondrial membrane (Homo sapiens)


name: STARD7 transports Q10 to plasma membrane (Homo sapiens)


name: Unknown dehydrogenase oxidizes 4-HBz (Homo sapiens)


name: PDSS1,2 ligates FPP to IPPP (Homo sapiens)


name: Unknown enzyme hydroxylates DMPhOH (Homo sapiens)


name: COQ2 ligates all-E-10PrP2 to PHB (Homo sapiens)


name: COQ7:COQ9 octamer hydroxylates DMQ10H2 (Homo sapiens)


name: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity

description: Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2.


name: Unknown enzyme(s) process 4-HMA to 4-Hbz (Homo sapiens)


name: mito-STARD7 transports Q10 to outer mitochondrial membrane (Mus musculus)


name: COQ7:COQ9 octamer hydroxylates DMQ10H2 (Mus musculus)


name: STARD7 transports Q10 to plasma membrane (Mus musculus)


name: PDSS1,2 ligates FPP to IPPP (Mus musculus)


name: COQ2 ligates all-E-10PrP2 to PHB (Mus musculus)


name: Ubiquinol biosynthesis (Rattus norvegicus)


name: HPDL dioxygenates HPPA (Rattus norvegicus)


name: COQ7:COQ9 octamer hydroxylates DMQ10H2 (Rattus norvegicus)


name: COQ5 methylates MDMQ10H2 (Rattus norvegicus)


name: STARD7 transports Q10 to plasma membrane (Rattus norvegicus)


name: PDSS1,2 ligates FPP to IPPP (Rattus norvegicus)


name: COQ6 hydroxylates DHB (Rattus norvegicus)


name: COQ3 methylates DHDB (Rattus norvegicus)


name: COQ3 methylates DeMQ10H2 (Rattus norvegicus)


name: COQ2 ligates all-E-10PrP2 to PHB (Rattus norvegicus)


name: mito-STARD7 transports Q10 to outer mitochondrial membrane (Rattus norvegicus)


name: COQ4 decarboxylates MHDB (Rattus norvegicus)


name: Ubiquinol biosynthesis (Canis familiaris)


name: COQ5 methylates MDMQ10H2 (Canis familiaris)


name: HPDL dioxygenates HPPA (Canis familiaris)


name: STARD7 transports Q10 to plasma membrane (Canis familiaris)


name: COQ3 methylates DeMQ10H2 (Canis familiaris)


name: COQ4 decarboxylates MHDB (Canis familiaris)


name: COQ6 hydroxylates DHB (Canis familiaris)


name: COQ7:COQ9 octamer hydroxylates DMQ10H2 (Canis familiaris)


name: PDSS1,2 ligates FPP to IPPP (Canis familiaris)


name: mito-STARD7 transports Q10 to outer mitochondrial membrane (Canis familiaris)


name: COQ2 ligates all-E-10PrP2 to PHB (Canis familiaris)


name: COQ2 ligates all-E-10PrP2 to PHB (Bos taurus)


name: mito-STARD7 transports Q10 to outer mitochondrial membrane (Bos taurus)


name: PDSS1,2 ligates FPP to IPPP (Bos taurus)


name: STARD7 transports Q10 to plasma membrane (Bos taurus)


name: COQ7:COQ9 octamer hydroxylates DMQ10H2 (Bos taurus)


name: COQ2 ligates all-E-10PrP2 to PHB (Danio rerio)


name: PDSS1,2 ligates FPP to IPPP (Danio rerio)


name: COQ7:COQ9 octamer hydroxylates DMQ10H2 (Danio rerio)


name: Ubiquinol biosynthesis (Xenopus tropicalis)


name: COQ7:COQ9 octamer hydroxylates DMQ10H2 (Xenopus tropicalis)


name: mito-STARD7 transports Q10 to outer mitochondrial membrane (Xenopus tropicalis)


name: COQ5 methylates MDMQ10H2 (Xenopus tropicalis)


name: HPDL dioxygenates HPPA (Xenopus tropicalis)


name: COQ6 hydroxylates DHB (Xenopus tropicalis)


name: COQ3 methylates DHDB (Xenopus tropicalis)


name: COQ2 ligates all-E-10PrP2 to PHB (Xenopus tropicalis)


name: STARD7 transports Q10 to plasma membrane (Xenopus tropicalis)


name: PDSS1,2 ligates FPP to IPPP (Xenopus tropicalis)


name: COQ3 methylates DeMQ10H2 (Xenopus tropicalis)


name: COQ4 decarboxylates MHDB (Xenopus tropicalis)


name: Ubiquinol biosynthesis (Drosophila melanogaster)


name: COQ6 hydroxylates DHB (Drosophila melanogaster)


name: COQ3 methylates DHDB (Drosophila melanogaster)


name: PDSS1,2 ligates FPP to IPPP (Drosophila melanogaster)


name: COQ7:COQ9 octamer hydroxylates DMQ10H2 (Drosophila melanogaster)


name: COQ5 methylates MDMQ10H2 (Drosophila melanogaster)


name: mito-STARD7 transports Q10 to outer mitochondrial membrane (Drosophila melanogaster)


name: COQ4 decarboxylates MHDB (Drosophila melanogaster)


name: STARD7 transports Q10 to plasma membrane (Drosophila melanogaster)


name: COQ3 methylates DeMQ10H2 (Drosophila melanogaster)


name: COQ2 ligates all-E-10PrP2 to PHB (Drosophila melanogaster)


name: Ubiquinol biosynthesis (Caenorhabditis elegans)


name: STARD7 transports Q10 to plasma membrane (Caenorhabditis elegans)


name: COQ3 methylates DHDB (Caenorhabditis elegans)


name: COQ2 ligates all-E-10PrP2 to PHB (Caenorhabditis elegans)


name: COQ4 decarboxylates MHDB (Caenorhabditis elegans)


name: COQ6 hydroxylates DHB (Caenorhabditis elegans)


name: COQ3 methylates DeMQ10H2 (Caenorhabditis elegans)


name: COQ5 methylates MDMQ10H2 (Caenorhabditis elegans)


name: mito-STARD7 transports Q10 to outer mitochondrial membrane (Caenorhabditis elegans)


name: Ubiquinol biosynthesis (Dictyostelium discoideum)


name: COQ7:COQ9 octamer hydroxylates DMQ10H2 (Dictyostelium discoideum)


name: COQ5 methylates MDMQ10H2 (Dictyostelium discoideum)


name: COQ3 methylates DeMQ10H2 (Dictyostelium discoideum)


name: COQ4 decarboxylates MHDB (Dictyostelium discoideum)


name: PDSS1,2 ligates FPP to IPPP (Dictyostelium discoideum)


name: COQ2 ligates all-E-10PrP2 to PHB (Dictyostelium discoideum)


name: COQ3 methylates DHDB (Dictyostelium discoideum)


name: COQ6 hydroxylates DHB (Dictyostelium discoideum)


name: HPDL dioxygenates HPPA (Dictyostelium discoideum)


name: Ubiquinol biosynthesis (Schizosaccharomyces pombe)


name: COQ7:COQ9 octamer hydroxylates DMQ10H2 (Schizosaccharomyces pombe)


name: COQ5 methylates MDMQ10H2 (Schizosaccharomyces pombe)


name: COQ3 methylates DeMQ10H2 (Schizosaccharomyces pombe)


name: COQ4 decarboxylates MHDB (Schizosaccharomyces pombe)


name: COQ2 ligates all-E-10PrP2 to PHB (Schizosaccharomyces pombe)


name: PDSS1,2 ligates FPP to IPPP (Schizosaccharomyces pombe)


name: COQ6 hydroxylates DHB (Schizosaccharomyces pombe)


name: COQ3 methylates DHDB (Schizosaccharomyces pombe)


name: Ubiquinol biosynthesis (Saccharomyces cerevisiae)


name: COQ4 decarboxylates MHDB (Saccharomyces cerevisiae)


name: COQ2 ligates all-E-10PrP2 to PHB (Saccharomyces cerevisiae)


name: COQ3 methylates DHDB (Saccharomyces cerevisiae)


name: COQ6 hydroxylates DHB (Saccharomyces cerevisiae)


name: COQ7:COQ9 octamer hydroxylates DMQ10H2 (Saccharomyces cerevisiae)


name: COQ5 methylates MDMQ10H2 (Saccharomyces cerevisiae)


name: PDSS1,2 ligates FPP to IPPP (Saccharomyces cerevisiae)


name: COQ3 methylates DeMQ10H2 (Saccharomyces cerevisiae)


name: Ubiquinol biosynthesis (Plasmodium falciparum)


name: COQ2 ligates all-E-10PrP2 to PHB (Plasmodium falciparum)


name: PDSS1,2 ligates FPP to IPPP (Plasmodium falciparum)


name: Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Sus scrofa)


name: Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Sus scrofa)


name: FLVCR1-1 transports heme from cytosol to extracellular region (Sus scrofa)


name: SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)


name: NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Sus scrofa)


name: SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Sus scrofa)


name: SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Sus scrofa)


name: SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)


name: SLC46A1 transports hemes from extracellular region to cytosol (Sus scrofa)


name: SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Sus scrofa)


name: CYBRD1:Heme reduces Fe3+ to Fe2+ (Sus scrofa)


name: apoTF binds 2Fe3+ to form holoTF (Sus scrofa)


name: FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Sus scrofa)


name: SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Sus scrofa)


name: ABCG2 tetramer transports heme from cytosol to extracellular region (Sus scrofa)


name: HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)


name: Transferrin endocytosis and recycling (Sus scrofa)


name: holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Sus scrofa)


name: apo-Transferrin dissociates from the receptor complex (Sus scrofa)


name: Acidification of Tf:TfR1 containing endosome (Sus scrofa)


name: STEAP3,STEAP4 reduce Fe3+ to Fe2+ (Sus scrofa)


name: MCOLN1 transports Fe2+ from endosome lumen to cytosol (Sus scrofa)


name: apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Sus scrofa)


name: Fe3+ dissociates from holoTF:TFRC dimer (Sus scrofa)


name: Transferrin endocytosis and recycling (Homo sapiens)


name: Acidification of Tf:TfR1 containing endosome (Homo sapiens)


name: MCOLN1 transports Fe2+ from endosome lumen to cytosol (Homo sapiens)


name: STEAP3,STEAP4 reduce Fe3+ to Fe2+ (Homo sapiens)


name: TFRC dimer binds 2xholoTF (Homo sapiens)


name: apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Homo sapiens)


name: TFR2 dimer binds 2xholoTF (Homo sapiens)


name: Fe3+ dissociates from holoTF:TFRC dimer (Homo sapiens)


name: apo-Transferrin dissociates from the receptor complex (Homo sapiens)


name: holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Homo sapiens)


name: Transferrin endocytosis and recycling (Mus musculus)


name: TFR2 dimer binds 2xholoTF (Mus musculus)


name: STEAP3,STEAP4 reduce Fe3+ to Fe2+ (Mus musculus)


name: TFRC dimer binds 2xholoTF (Mus musculus)


name: MCOLN1 transports Fe2+ from endosome lumen to cytosol (Mus musculus)


name: apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Mus musculus)


name: Fe3+ dissociates from holoTF:TFRC dimer (Mus musculus)


name: apo-Transferrin dissociates from the receptor complex (Mus musculus)


name: holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Mus musculus)


name: Acidification of Tf:TfR1 containing endosome (Mus musculus)


name: Transferrin endocytosis and recycling (Rattus norvegicus)


name: apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Rattus norvegicus)


name: holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Rattus norvegicus)


name: STEAP3,STEAP4 reduce Fe3+ to Fe2+ (Rattus norvegicus)


name: HFE binds TFRC dimer (Rattus norvegicus)


name: MCOLN1 transports Fe2+ from endosome lumen to cytosol (Rattus norvegicus)


name: Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)


name: TFRC dimer binds 2xholoTF (Rattus norvegicus)


name: apo-Transferrin dissociates from the receptor complex (Rattus norvegicus)


name: ATP6AP1 binds V-ATPase (Rattus norvegicus)


name: TFR2 dimer binds 2xholoTF (Rattus norvegicus)


name: Fe3+ dissociates from holoTF:TFRC dimer (Rattus norvegicus)


name: Transferrin endocytosis and recycling (Canis familiaris)


name: MCOLN1 transports Fe2+ from endosome lumen to cytosol (Canis familiaris)


name: Acidification of Tf:TfR1 containing endosome (Canis familiaris)


name: ATP6AP1 binds V-ATPase (Canis familiaris)


name: STEAP3,STEAP4 reduce Fe3+ to Fe2+ (Canis familiaris)


name: Transferrin endocytosis and recycling (Bos taurus)


name: apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Bos taurus)


name: MCOLN1 transports Fe2+ from endosome lumen to cytosol (Bos taurus)


name: apo-Transferrin dissociates from the receptor complex (Bos taurus)


name: holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Bos taurus)


name: Fe3+ dissociates from holoTF:TFRC dimer (Bos taurus)


name: Acidification of Tf:TfR1 containing endosome (Bos taurus)


name: STEAP3,STEAP4 reduce Fe3+ to Fe2+ (Bos taurus)


name: Transferrin endocytosis and recycling (Danio rerio)


name: MCOLN1 transports Fe2+ from endosome lumen to cytosol (Danio rerio)


name: Acidification of Tf:TfR1 containing endosome (Danio rerio)


name: Transferrin endocytosis and recycling (Xenopus tropicalis)


name: TFR2 dimer binds 2xholoTF (Xenopus tropicalis)


name: Acidification of Tf:TfR1 containing endosome (Xenopus tropicalis)


name: ATP6AP1 binds V-ATPase (Xenopus tropicalis)


name: STEAP3,STEAP4 reduce Fe3+ to Fe2+ (Xenopus tropicalis)


name: MCOLN1 transports Fe2+ from endosome lumen to cytosol (Xenopus tropicalis)


name: Transferrin endocytosis and recycling (Gallus gallus)


name: STEAP3,STEAP4 reduce Fe3+ to Fe2+ (Gallus gallus)


name: holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Gallus gallus)


name: apo-Transferrin dissociates from the receptor complex (Gallus gallus)


name: Acidification of Tf:TfR1 containing endosome (Gallus gallus)


name: TFRC dimer binds 2xholoTF (Gallus gallus)


name: apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Gallus gallus)


name: Fe3+ dissociates from holoTF:TFRC dimer (Gallus gallus)


name: MCOLN1 transports Fe2+ from endosome lumen to cytosol (Gallus gallus)


name: Transferrin endocytosis and recycling (Drosophila melanogaster)


name: MCOLN1 transports Fe2+ from endosome lumen to cytosol (Drosophila melanogaster)


name: ATP6AP1 binds V-ATPase (Drosophila melanogaster)


name: Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)


name: Transferrin endocytosis and recycling (Caenorhabditis elegans)


name: Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)


name: MCOLN1 transports Fe2+ from endosome lumen to cytosol (Caenorhabditis elegans)


name: ATP6AP1 binds V-ATPase (Caenorhabditis elegans)


name: Transferrin endocytosis and recycling (Dictyostelium discoideum)


name: MCOLN1 transports Fe2+ from endosome lumen to cytosol (Dictyostelium discoideum)


name: Acidification of Tf:TfR1 containing endosome (Dictyostelium discoideum)


name: Transferrin endocytosis and recycling (Schizosaccharomyces pombe)


name: Acidification of Tf:TfR1 containing endosome (Schizosaccharomyces pombe)


name: Transferrin endocytosis and recycling (Saccharomyces cerevisiae)


name: Acidification of Tf:TfR1 containing endosome (Saccharomyces cerevisiae)


name: Transferrin endocytosis and recycling (Plasmodium falciparum)


name: Acidification of Tf:TfR1 containing endosome (Plasmodium falciparum)


name: Iron uptake and transport (Homo sapiens)


name: SLC46A1 transports hemes from extracellular region to cytosol (Homo sapiens)


name: CYBRD1:Heme reduces Fe3+ to Fe2+ (Homo sapiens)


name: SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Homo sapiens)


name: SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)


name: FLVCR1-1 transports heme from cytosol to extracellular region (Homo sapiens)


name: SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Homo sapiens)


name: Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Homo sapiens)


name: apoTF binds 2Fe3+ to form holoTF (Homo sapiens)


name: ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs (Homo sapiens)


name: SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Homo sapiens)


name: SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Homo sapiens)


name: SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)


name: HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)


name: ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)


name: Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Homo sapiens)


name: FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Homo sapiens)


name: SLC22A17 binds LCN2:2,5DHBA:Fe3+ (Homo sapiens)


name: NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Homo sapiens)


name: Iron uptake and transport (Mus musculus)


name: SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Mus musculus)


name: ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)


name: SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Mus musculus)


name: SLC46A1 transports hemes from extracellular region to cytosol (Mus musculus)


name: apoTF binds 2Fe3+ to form holoTF (Mus musculus)


name: NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Mus musculus)


name: HMOX1 dimer, HMOX2 cleave heme (Mus musculus)


name: SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Mus musculus)


name: SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)


name: SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Mus musculus)


name: Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Mus musculus)


name: CYBRD1:Heme reduces Fe3+ to Fe2+ (Mus musculus)


name: FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Mus musculus)


name: Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Mus musculus)


name: FLVCR1-1 transports heme from cytosol to extracellular region (Mus musculus)


name: SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)


name: Iron uptake and transport (Rattus norvegicus)


name: SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Rattus norvegicus)


name: SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Rattus norvegicus)


name: Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Rattus norvegicus)


name: CYBRD1:Heme reduces Fe3+ to Fe2+ (Rattus norvegicus)


name: apoTF binds 2Fe3+ to form holoTF (Rattus norvegicus)


name: LCN2:2,5DHBA binds Fe3+ (Rattus norvegicus)


name: FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Rattus norvegicus)


name: HMOX1 dimer, HMOX2 cleave heme (Rattus norvegicus)


name: SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Rattus norvegicus)


name: CUL1, SKP1, FBXL5 bind (Rattus norvegicus)


name: NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Rattus norvegicus)


name: Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Rattus norvegicus)


name: SLC46A1 transports hemes from extracellular region to cytosol (Rattus norvegicus)


name: SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)


name: ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)


name: SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)


name: SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Rattus norvegicus)


name: Iron uptake and transport (Canis familiaris)


name: SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Canis familiaris)


name: SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)


name: FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Canis familiaris)


name: CUL1, SKP1, FBXL5 bind (Canis familiaris)


name: HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)


name: NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Canis familiaris)


name: Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Canis familiaris)


name: Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Canis familiaris)


name: LCN2:2,5DHBA binds Fe3+ (Canis familiaris)


name: SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)


name: SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Canis familiaris)


name: SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Canis familiaris)


name: SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Canis familiaris)


name: ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)


name: SLC46A1 transports hemes from extracellular region to cytosol (Canis familiaris)


name: FLVCR1-1 transports heme from cytosol to extracellular region (Canis familiaris)


name: CYBRD1:Heme reduces Fe3+ to Fe2+ (Canis familiaris)


name: NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Bos taurus)


name: Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Bos taurus)


name: SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)


name: SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Bos taurus)


name: SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)


name: HMOX1 dimer, HMOX2 cleave heme (Bos taurus)


name: ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)


name: SLC46A1 transports hemes from extracellular region to cytosol (Bos taurus)


name: Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Bos taurus)


name: SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)


name: apoTF binds 2Fe3+ to form holoTF (Bos taurus)


name: CYBRD1:Heme reduces Fe3+ to Fe2+ (Bos taurus)


name: SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Bos taurus)


name: FLVCR1-1 transports heme from cytosol to extracellular region (Bos taurus)


name: SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Bos taurus)


name: FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Bos taurus)


name: SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)


name: NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Danio rerio)


name: SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Danio rerio)


name: SLC46A1 transports hemes from extracellular region to cytosol (Danio rerio)


name: FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Danio rerio)


name: Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)


name: CYBRD1:Heme reduces Fe3+ to Fe2+ (Danio rerio)


name: HMOX1 dimer, HMOX2 cleave heme (Danio rerio)


name: SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Danio rerio)


name: PIP3 activates AKT signaling (Danio rerio)


name: RAC1,RAC2,RHOG activate PI3K (Danio rerio)


name: Generation of second messenger molecules (Danio rerio)


name: PLC-gamma1 hydrolyses PIP2 (Danio rerio)


name: Translocation of PLC-gamma1 to PIP2 (Danio rerio)


name: Generation of second messenger molecules (Homo sapiens)


name: p-SLP-76:ADAP binds Ena/VASP (Homo sapiens)


name: Disassociation of PLC-gamma1 from LAT (Homo sapiens)


name: Disassociation of PLC-gamma1 from SLP-76 (Homo sapiens)


name: Recruitment of PLC-gamma1 to SLP-76 (Homo sapiens)


name: Recruitment of Gads to LAT (Homo sapiens)


name: Translocation of PLC-gamma1 to PIP2 (Homo sapiens)


name: Phosphorylation of PLC-gamma1 (Homo sapiens)


name: Phosphorylation of SLP-76 (Homo sapiens)


name: Recruitment of PLC-gamma1 to LAT (Homo sapiens)


name: Phosphorylation of TBSMs in LAT (Homo sapiens)


name: PLC-gamma1 hydrolyses PIP2 (Homo sapiens)


name: Recruitment of ITK to SLP-76 (Homo sapiens)


name: Recruitment of SLP-76 to Gads (Homo sapiens)


name: Generation of second messenger molecules (Mus musculus)


name: Phosphorylation of PLC-gamma1 (Mus musculus)


name: Recruitment of SLP-76 to Gads (Mus musculus)


name: Phosphorylation of SLP-76 (Mus musculus)


name: Translocation of PLC-gamma1 to PIP2 (Mus musculus)


name: Recruitment of PLC-gamma1 to LAT (Mus musculus)


name: Recruitment of ITK to SLP-76 (Mus musculus)


name: PLC-gamma1 hydrolyses PIP2 (Mus musculus)


name: Recruitment of PLC-gamma1 to SLP-76 (Mus musculus)


name: Disassociation of PLC-gamma1 from LAT (Mus musculus)


name: Disassociation of PLC-gamma1 from SLP-76 (Mus musculus)


name: Phosphorylation of TBSMs in LAT (Mus musculus)


name: Recruitment of Gads to LAT (Mus musculus)


name: Generation of second messenger molecules (Rattus norvegicus)


name: Disassociation of PLC-gamma1 from LAT (Rattus norvegicus)


name: Recruitment of ITK to SLP-76 (Rattus norvegicus)


name: Translocation of PLC-gamma1 to PIP2 (Rattus norvegicus)


name: Phosphorylation of TBSMs in LAT (Rattus norvegicus)


name: Disassociation of PLC-gamma1 from SLP-76 (Rattus norvegicus)


name: Phosphorylation of PLC-gamma1 (Rattus norvegicus)


name: Phosphorylation of SLP-76 (Rattus norvegicus)


name: Recruitment of SLP-76 to Gads (Rattus norvegicus)


name: PLC-gamma1 hydrolyses PIP2 (Rattus norvegicus)


name: Recruitment of Gads to LAT (Rattus norvegicus)


name: Recruitment of PLC-gamma1 to LAT (Rattus norvegicus)


name: Recruitment of PLC-gamma1 to SLP-76 (Rattus norvegicus)


name: Generation of second messenger molecules (Canis familiaris)


name: PLC-gamma1 hydrolyses PIP2 (Canis familiaris)


name: Recruitment of PLC-gamma1 to SLP-76 (Canis familiaris)


name: Recruitment of PLC-gamma1 to LAT (Canis familiaris)


name: Recruitment of Gads to LAT (Canis familiaris)


name: Disassociation of PLC-gamma1 from SLP-76 (Canis familiaris)


name: Translocation of PLC-gamma1 to PIP2 (Canis familiaris)


name: Disassociation of PLC-gamma1 from LAT (Canis familiaris)


name: Phosphorylation of PLC-gamma1 (Canis familiaris)


name: Phosphorylation of TBSMs in LAT (Canis familiaris)


name: Phosphorylation of SLP-76 (Canis familiaris)


name: Recruitment of SLP-76 to Gads (Canis familiaris)


name: Recruitment of ITK to SLP-76 (Canis familiaris)


name: Generation of second messenger molecules (Bos taurus)


name: Disassociation of PLC-gamma1 from LAT (Bos taurus)


name: Recruitment of PLC-gamma1 to LAT (Bos taurus)


name: Disassociation of PLC-gamma1 from SLP-76 (Bos taurus)


name: Recruitment of PLC-gamma1 to SLP-76 (Bos taurus)


name: Translocation of PLC-gamma1 to PIP2 (Bos taurus)


name: Recruitment of ITK to SLP-76 (Bos taurus)


name: Recruitment of SLP-76 to Gads (Bos taurus)


name: Phosphorylation of TBSMs in LAT (Bos taurus)


name: Phosphorylation of PLC-gamma1 (Bos taurus)


name: Generation of second messenger molecules (Sus scrofa)


name: Recruitment of PLC-gamma1 to LAT (Sus scrofa)


name: Translocation of PLC-gamma1 to PIP2 (Sus scrofa)


name: Recruitment of ITK to SLP-76 (Sus scrofa)


name: Recruitment of SLP-76 to Gads (Sus scrofa)


name: Phosphorylation of PLC-gamma1 (Sus scrofa)


name: Phosphorylation of TBSMs in LAT (Sus scrofa)


name: Disassociation of PLC-gamma1 from LAT (Sus scrofa)


name: Disassociation of PLC-gamma1 from SLP-76 (Sus scrofa)


name: Recruitment of PLC-gamma1 to SLP-76 (Sus scrofa)


name: Generation of second messenger molecules (Xenopus tropicalis)


name: Phosphorylation of PLC-gamma1 (Xenopus tropicalis)


name: p-SLP-76 binds ADAP (Xenopus tropicalis)


name: PLC-gamma1 hydrolyses PIP2 (Xenopus tropicalis)


name: Translocation of PLC-gamma1 to PIP2 (Xenopus tropicalis)


name: Generation of second messenger molecules (Gallus gallus)


name: PLC-gamma1 hydrolyses PIP2 (Gallus gallus)


name: Phosphorylation of PLC-gamma1 (Gallus gallus)


name: Translocation of PLC-gamma1 to PIP2 (Gallus gallus)


name: Generation of second messenger molecules (Drosophila melanogaster)


name: p-SLP-76 binds NCK (Drosophila melanogaster)


name: Phosphorylation of PLC-gamma1 (Drosophila melanogaster)


name: Translocation of PLC-gamma1 to PIP2 (Drosophila melanogaster)


name: PLC-gamma1 hydrolyses PIP2 (Drosophila melanogaster)


name: Generation of second messenger molecules (Dictyostelium discoideum)


name: PLC-gamma1 hydrolyses PIP2 (Dictyostelium discoideum)


name: Translocation of PLC-gamma1 to PIP2 (Dictyostelium discoideum)


name: Generation of second messenger molecules (Schizosaccharomyces pombe)


name: PLC-gamma1 hydrolyses PIP2 (Schizosaccharomyces pombe)


name: Translocation of PLC-gamma1 to PIP2 (Schizosaccharomyces pombe)


name: Generation of second messenger molecules (Saccharomyces cerevisiae)


name: PLC-gamma1 hydrolyses PIP2 (Saccharomyces cerevisiae)


name: Translocation of PLC-gamma1 to PIP2 (Saccharomyces cerevisiae)


name: Generation of second messenger molecules (Plasmodium falciparum)


name: PLC-gamma1 hydrolyses PIP2 (Plasmodium falciparum)


name: Translocation of PLC-gamma1 to PIP2 (Plasmodium falciparum)


name: Phosphorylation of CD3 and TCR zeta chains (Danio rerio)


name: Interaction of Csk with PAG (Danio rerio)


name: PTPN22 dissociates from CSK (Danio rerio)


name: Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)


name: Inactivation of LCK by PTPN22 (Homo sapiens)


name: Interaction of Csk with PAG (Homo sapiens)


name: Inactivation of Lck by Csk (Homo sapiens)


name: PTPN22 dissociates from CSK (Homo sapiens)


name: Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)


name: Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)


name: Phosphorylation of CD3 and TCR zeta chains (Mus musculus)


name: Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)


name: Interaction of Csk with PAG (Mus musculus)


name: PTPN22 dissociates from CSK (Mus musculus)


name: Inactivation of Lck by Csk (Mus musculus)


name: Phosphorylation of ITAM motifs in CD3 complexes (Mus musculus)


name: Inactivation of LCK by PTPN22 (Mus musculus)


name: Phosphorylation of CD3 and TCR zeta chains (Rattus norvegicus)


name: Interaction of Csk with PAG (Rattus norvegicus)


name: PTPN22 dissociates from CSK (Rattus norvegicus)


name: Dephosphorylation of Lck-pY505 by CD45 (Rattus norvegicus)


name: Inactivation of Lck by Csk (Rattus norvegicus)


name: Inactivation of LCK by PTPN22 (Rattus norvegicus)


name: Phosphorylation of ITAM motifs in CD3 complexes (Rattus norvegicus)


name: Phosphorylation of CD3 and TCR zeta chains (Canis familiaris)


name: Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)


name: Inactivation of Lck by Csk (Canis familiaris)


name: Inactivation of LCK by PTPN22 (Canis familiaris)


name: PTPN22 dissociates from CSK (Canis familiaris)


name: Phosphorylation of ITAM motifs in CD3 complexes (Canis familiaris)


name: Interaction of Csk with PAG (Canis familiaris)


name: Phosphorylation of CD3 and TCR zeta chains (Bos taurus)


name: Dephosphorylation of Lck-pY505 by CD45 (Bos taurus)


name: Inactivation of LCK by PTPN22 (Bos taurus)


name: Phosphorylation of ITAM motifs in CD3 complexes (Bos taurus)


name: PTPN22 dissociates from CSK (Bos taurus)


name: Interaction of Csk with PAG (Bos taurus)


name: Phosphorylation of CD3 and TCR zeta chains (Sus scrofa)


name: Dephosphorylation of Lck-pY505 by CD45 (Sus scrofa)


name: Inactivation of LCK by PTPN22 (Sus scrofa)


name: Phosphorylation of ITAM motifs in CD3 complexes (Sus scrofa)


name: PTPN22 dissociates from CSK (Sus scrofa)


name: Interaction of Csk with PAG (Sus scrofa)


name: Phosphorylation of CD3 and TCR zeta chains (Xenopus tropicalis)


name: Interaction of Csk with PAG (Xenopus tropicalis)


name: Phosphorylation of CD3 and TCR zeta chains (Gallus gallus)


name: Interaction of Csk with PAG (Gallus gallus)


name: Inactivation of LCK by PTPN22 (Gallus gallus)


name: Phosphorylation of ITAM motifs in CD3 complexes (Gallus gallus)


name: Inactivation of Lck by Csk (Gallus gallus)


name: Dephosphorylation of Lck-pY505 by CD45 (Gallus gallus)


name: PTPN22 dissociates from CSK (Gallus gallus)


name: Translocation of PDK1 to Plasma membrane (Danio rerio)


name: Change of PKC theta conformation (Homo sapiens)


name: Interaction of Bcl10 to CARMA1 (Homo sapiens)


name: Ubiquitination of NEMO by TRAF6 (Homo sapiens)


name: beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)


name: Phosphorylation of CARMA1 (Homo sapiens)


name: Activation of IKK complex (Homo sapiens)


name: NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)


name: Oligomerization of CARMA1 (Homo sapiens)


name: Translocation of TRAF6 to CBM complex (Homo sapiens)


name: Phosphorylation of PKC theta (Homo sapiens)


name: Interaction and oligomerization of MALT1 to Bcl10 (Homo sapiens)


name: Activation of TAK1-TAB2 complex (Homo sapiens)


name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)


name: Auto-ubiquitination of TRAF6 (Homo sapiens)


name: Translocation of PDK1 to Plasma membrane (Homo sapiens)


name: Recruitment of PI3K to plasma membrane (Homo sapiens)


name: Translocation of CARMA1 to Plasma membrane (Homo sapiens)


name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)


name: Translocation of PKC theta to plasma membrane (Homo sapiens)


name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)


name: Hydrolysis of PIP3 to PI(3,4)P2 (Homo sapiens)


name: Interaction and oligomerization of MALT1 to Bcl10 (Mus musculus)


name: Hydrolysis of PIP3 to PI(3,4)P2 (Mus musculus)


name: beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Mus musculus)


name: Translocation of CARMA1 to Plasma membrane (Mus musculus)


name: Ubiquitination of NEMO by TRAF6 (Mus musculus)


name: Phosphorylation of CARMA1 (Mus musculus)


name: Activation of TAK1-TAB2 complex (Mus musculus)


name: Interaction of Bcl10 to CARMA1 (Mus musculus)


name: Oligomerization of CARMA1 (Mus musculus)


name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)


name: Translocation of TRAF6 to CBM complex (Mus musculus)


name: Translocation of PDK1 to Plasma membrane (Mus musculus)


name: Translocation of PKC theta to plasma membrane (Mus musculus)


name: Auto-ubiquitination of TRAF6 (Mus musculus)


name: Phosphorylation of PKC theta (Mus musculus)


name: Activation of IKK complex (Mus musculus)


name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Mus musculus)


name: NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)


name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Mus musculus)


name: Change of PKC theta conformation (Mus musculus)


name: Recruitment of PI3K to plasma membrane (Mus musculus)


name: Downstream TCR signaling (Rattus norvegicus)


name: Activation of IKK complex (Rattus norvegicus)


name: Hydrolysis of PIP3 to PI(3,4)P2 (Rattus norvegicus)


name: Oligomerization of Bcl10 (Rattus norvegicus)


name: Interaction and oligomerization of MALT1 to Bcl10 (Rattus norvegicus)


name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)


name: Oligomerization of CARMA1 (Rattus norvegicus)


name: Translocation of TRAF6 to CBM complex (Rattus norvegicus)


name: Activation of TAK1-TAB2 complex (Rattus norvegicus)


name: Translocation of CARMA1 to Plasma membrane (Rattus norvegicus)


name: Translocation of PDK1 to Plasma membrane (Rattus norvegicus)


name: Recruitment of PI3K to plasma membrane (Rattus norvegicus)


name: Translocation of PKC theta to plasma membrane (Rattus norvegicus)


name: Phosphorylation of PKC theta (Rattus norvegicus)


name: Change of PKC theta conformation (Rattus norvegicus)


name: Interaction of Bcl10 to CARMA1 (Rattus norvegicus)


name: Phosphorylation of CARMA1 (Rattus norvegicus)


name: Phosphorylation of Bcl10 (Rattus norvegicus)


name: Downstream TCR signaling (Canis familiaris)


name: NFKB1:RELA translocates from the cytosol to the nucleus (Canis familiaris)


name: Change of PKC theta conformation (Canis familiaris)


name: Activation of TAK1-TAB2 complex (Canis familiaris)


name: Interaction and oligomerization of MALT1 to Bcl10 (Canis familiaris)


name: Oligomerization of Bcl10 (Canis familiaris)


name: Translocation of CARMA1 to Plasma membrane (Canis familiaris)


name: beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)


name: Phosphorylation of PKC theta (Canis familiaris)


name: Ubiquitination of NEMO by TRAF6 (Canis familiaris)


name: Translocation of PKC theta to plasma membrane (Canis familiaris)


name: Phosphorylation of CARMA1 (Canis familiaris)


name: Translocation of PDK1 to Plasma membrane (Canis familiaris)


name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)


name: Auto-ubiquitination of TRAF6 (Canis familiaris)


name: Interaction of Bcl10 to CARMA1 (Canis familiaris)


name: Translocation of TRAF6 to CBM complex (Canis familiaris)


name: Recruitment of PI3K to plasma membrane (Canis familiaris)


name: Activation of IKK complex (Canis familiaris)


name: Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)


name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)


name: Oligomerization of CARMA1 (Canis familiaris)


name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)


name: Phosphorylation of Bcl10 (Canis familiaris)


name: Translocation of CARMA1 to Plasma membrane (Bos taurus)


name: Change of PKC theta conformation (Bos taurus)


name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Bos taurus)


name: Translocation of PKC theta to plasma membrane (Bos taurus)


name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)


name: Phosphorylation of PKC theta (Bos taurus)


name: Translocation of PDK1 to Plasma membrane (Bos taurus)


name: NFKB1:RELA translocates from the cytosol to the nucleus (Bos taurus)


name: Translocation of TRAF6 to CBM complex (Bos taurus)


name: beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Bos taurus)


name: Interaction of Bcl10 to CARMA1 (Bos taurus)


name: Interaction and oligomerization of MALT1 to Bcl10 (Bos taurus)


name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)


name: Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)


name: Recruitment of PI3K to plasma membrane (Bos taurus)


name: Activation of TAK1-TAB2 complex (Bos taurus)


name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Sus scrofa)


name: Hydrolysis of PIP3 to PI(3,4)P2 (Sus scrofa)


name: Interaction of Bcl10 to CARMA1 (Sus scrofa)


name: Translocation of PDK1 to Plasma membrane (Sus scrofa)


name: Translocation of TRAF6 to CBM complex (Sus scrofa)


name: Interaction and oligomerization of MALT1 to Bcl10 (Sus scrofa)


name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)


name: Activation of TAK1-TAB2 complex (Sus scrofa)


name: Translocation of CARMA1 to Plasma membrane (Sus scrofa)


name: Change of PKC theta conformation (Sus scrofa)


name: Recruitment of PI3K to plasma membrane (Sus scrofa)


name: Ubiquitination of NEMO by TRAF6 (Sus scrofa)


name: Translocation of PKC theta to plasma membrane (Sus scrofa)


name: Phosphorylation of PKC theta (Sus scrofa)


name: NFKB1:RELA translocates from the cytosol to the nucleus (Sus scrofa)


name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Sus scrofa)


name: Auto-ubiquitination of TRAF6 (Sus scrofa)


name: Downstream TCR signaling (Xenopus tropicalis)


name: Oligomerization of CARMA1 (Xenopus tropicalis)


name: Translocation of CARMA1 to Plasma membrane (Xenopus tropicalis)


name: Hydrolysis of PIP3 to PI(3,4)P2 (Xenopus tropicalis)


name: Translocation of PDK1 to Plasma membrane (Xenopus tropicalis)


name: Downstream TCR signaling (Gallus gallus)


name: beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Gallus gallus)


name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)


name: Interaction and oligomerization of MALT1 to Bcl10 (Gallus gallus)


name: Oligomerization of CARMA1 (Gallus gallus)


name: Oligomerization of Bcl10 (Gallus gallus)


name: NFKB1:RELA translocates from the cytosol to the nucleus (Gallus gallus)


name: Interaction of Bcl10 to CARMA1 (Gallus gallus)