Pleural fistula

description: An abnormal communication between the pleural cavity and another anatomic site.


Refractory Fibrosarcoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Fibrosarcoma that is resistant to treatment.


Metastatic Melanoma in the Skin

description: A melanoma that has spread to the skin from a cutaneous or extracutaneous primary site.


Substance-Induced Anxiety Disorder

description: An anxiety disorder in which the symptoms of anxiety have been determined to be etiologically related to the direct physiological effects of a substance (i.e., a drug of abuse, a medication, or toxin exposure).


name: Hodgkin's disease lymphocyte predominance type recurrent

description: An antiquated term that refers to the reemergence of either nodular lymphocyte predominant Hodgkin lymphoma or lymphocyte-rich classical Hodgkin lymphoma after a period of remission.


name: Clinical Stage I Esophageal Adenocarcinoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IIIC Fallopian Tube Cancer AJCC v8

description: Stage IIIC includes: T3c, N0/N1, M0. T3c: Fallopian tube cancer with macroscopic peritoneal metastasis beyond the pelvis more than 2 cm in greatest dimension with or without metastasis to the retroperitoneal lymph nodes (includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ). N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Vascular hemorrhagic disorders

description: A hemorrhagic disorder that is caused by pathologic changes in the vasculature.


Pregnancy Mood Swing

description: The fluctuations in the mental and emotional state of an individual during pregnancy.


Peripheral Vascular Insufficiency

description: A condition in which there is inadequate blood flow through the peripheral blood vessels due to intrinsic disease of the vasculature.


name: Amnestic disorders due to a general medical condition

description: A disorder involving memory impairment (either anterograde or retrograde) that is etiologically linked to the direct physiological consequence of a general medical condition. The memory impairment is not the result of a delirium or dementia.


name: Advanced Gastric Small Cell Neuroendocrine Carcinoma

description: A gastric small cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Metastatic Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: Extrapulmonary small cell neuroendocrine carcinoma that has spread to another anatomic site.


name: Pancreatic Mucinous-Cystic Neoplasm, Low Grade

description: A non-invasive mucinous cystic neoplasm that arises from the pancreas and is characterized by the presence of mild dysplasia and absence of mitotic figures.


name: Hereditary coagulation factor deficiency

description: An inherited blood coagulation disorder characterized by deficiency of one of the coagulation factors, resulting in bleeding.


Cytomegalovirus End-Organ Disease

description: Tissue-invasive cytomegalovirus infection, typically seen in solid-organ transplant recipients.


Myelofibrosis due to another disorder

description: Myelofibrosis that develops in patients with a history of hematologic malignancies or toxic injury to the bone marrow.


Astler-Coller A Colon Carcinoma

description: Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


name: Prostate Ductal Adenocarcinoma, Papillary Pattern

description: A prostate ductal adenocarcinoma characterized by the presence of a papillary growth pattern.


name: Pathologic Stage 0 Esophageal Adenocarcinoma AJCC v8

description: Stage 0 includes: Tis, N0, M0, GN/A. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. GN/A: Grade non-applicable. (AJCC 8th ed.)


Early Favorable Hodgkin Lymphoma

description: An early Hodgkin lymphoma with favorable prognosis.


name: Non-Neoplastic Chronic Respiratory System Disorder

description: A non-neoplastic longstanding disorder of the respiratory system.


Stage IV Prostate Cancer AJCC v8

description: Stage IV includes: IVA: Any T, N1, M0, PSA: Any, Grade Group: Any; IVB: Any T, N0, M1, PSA: Any, Grade Group: Any. N0: Prostate cancer with no positive regional nodes. N1: Prostate cancer with metastases in regional node(s). M0: Prostate cancer without evidence of distant metastasis. M1: Prostate cancer with distant metastasis. (AJCC 8th ed.)


name: Human immunodeficiency virus leukoencephalopathy


Childhood Kidney Disorder

description: A kidney disorder that appears during childhood.


Emotional problems

description: A perceived issue with a person's emotional wellbeing.


name: Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IVA includes: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Clear cell tumor

description: A purely morphologic term that describes a neoplasm in which all or the majority of the neoplastic cells have a clear cytoplasm, when examined under light microscopy, using the conventional staining method (H-E). This term does not provide any information about the nature of the neoplasm (benign or malignant), cell of origin (e.g. epithelial versus mesenchymal versus hematopoietic), or prognosis. Further examination using special stains and/or immunohistochemistry is required to appropriately classify this tumor.


High-CSD Melanoma

description: A cutaneous melanoma that develops on sun-exposed sites with a high degree of cumulative sun damage (CSD).


Recurrent Malignant Endocrine Neoplasm

description: Reemergence of a malignant endocrine neoplasm after a period of remission.


name: Anemia due to disorders of nucleotide metabolism

description: A group of hemolytic anemias that result from either the deficiency or overproduction of several enzymes involved in metabolizing nucleotides.


Metastatic Neuroendocrine Tumor

description: A neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


name: Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma by AJCC v8 Stage

description: A term that refers to the staging of adrenal gland pheochromocytoma and sympathetic paraganglioma, following the rules of the TNM AJCC v8 classification system. Parasympathetic paragangliomas are not staged because they are largely benign. This staging system does not apply to neuroendocrine tumors of the pancreas (are staged according to the classification for neuroendocrine tumors of the pancreas) and carotid body tumors (not staged). (from AJCC 8th Ed.)


Recurrent Retinoblastoma

description: The reemergence of retinoblastoma after a period of remission.


Invasive Malignant Neoplasm

description: Cancer that has spread beyond the layer of tissue in which it developed and is growing into surrounding, healthy tissues.


name: Chronic Myelomonocytic Leukemia with Eosinophilia

description: A chronic myelomonocytic leukemia characterized by a peripheral blood eosinophil count of equal or greater than 1.5x10E9/L, and absence of PDGFRA or PDGFRB gene abnormalities.


name: Advanced Platinum-Resistant Malignant Germ Cell Tumor

description: A platinum-resistant malignant germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage IIIB Fallopian Tube Cancer AJCC v8

description: Stage IIIB includes: T3b, N0/N1, M0. T3b: Fallopian tube cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


name: Ampulla of Vater Invasive Papillary Adenocarcinoma

description: An invasive adenocarcinoma that arises from an exophytic papillary neoplasm of the ampulla of Vater.


Stage IVC Appendix Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1b, Any G.  M1b: Nonperitoneal metastasis.  (AJCC 7th ed.)


name: Unresectable Bladder Small Cell Neuroendocrine Carcinoma

description: Bladder small cell neuroendocrine carcinoma that is not amenable to surgical resection.


Repeat Expansion Disease

description: A class of genetic diseases that occur when microsatellite repeats expand beyond a threshold length.


name: Anal Adenocarcinoma within Anorectal Fistula

description: An anal adenocarcinoma arising from the lining of an anorectal fistulous tract.  The overlying anal mucosa does not show evidence of neoplastic changes.  Some cases are associated with Crohn disease.


name: idiopathic normal pressure hydrocephalus

description: A disorder characterized by hydrocephalus in the setting of normal cerebrospinal fluid pressure, gait apraxia, impaired cognition and urinary urgency or incontinence.


Lyme Arthritis

description: Joint inflammation, most often affecting large joints, associated with Lyme disease, presenting months after infection.


Stage IA Cutaneous Melanoma AJCC v7

description: Stage IA includes: T1a, N0, M0.  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and with mitosis less than 1/mm2.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


name: Stage IA Fallopian Tube Cancer AJCC v6 and v7

description: Stage IA includes: T1a, N0, M0. T1a: Tumor limited to one tube, without penetrating the serosal surface; no ascites.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Benign Infratentorial Neoplasms

description: A neoplasm that arises from the infratentorial region and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Acute Lymphoblastic Leukemia by Gene Expression Profile

description: Gene expression-based patient cluster groups in acute lymphoblastic leukemia.


Composite paraganglioma

description: A neoplasm that combines morphologic characteristics of paraganglioma and neuroectodermal tumors such as neuroblastoma, ganglioneuroma, ganglioneuroblastoma, or peripheral nerve sheath tumor.


Recurrent pyogenic cholangitis

description: A recurrent form of cholangitis that is characterized by intrabiliary pigment stone formation, biliary tree stricture and obstruction, and recurrent bouts of cholangitis. There is an association with biliary parasitosis, but evidence supporting these infections in the pathogenesis of recurrent pyogenic cholangitis is inconclusive. The most common causes of death are sepsis, liver failure, or complications from cirrhosis. Patients are also at increased risk of cholangiocarcinoma.


name: Stage II Ampulla of Vater Cancer AJCC v8

description: Stage II includes: IIA: T3a, N0, M0; IIB: T3b, N0, M0. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Germinative Follicular Epithelium Neoplasm

description: A neoplasm involving the germinative follicular epithelium.


name: Infectious disease of genitourinary system

description: An acute or chronic infectious process affecting any part of the genitourinary system.


name: Myeloid/Lymphoid Neoplasms with ETV6-ABL1

description: Hematologic neoplasms characterized by t(9;12)(q34.1;p13.2) that results in ETV6-ABL1 gene fusion. They have clinicopathological features of chronic myeloid leukemia with frequent eosinophilia.


name: Childhood Malignant Digestive System Neoplasm

description: A malignant neoplasm that affects any part of the digestive system and occurs during childhood.


name: Stage IV Lentigo Maligna Melanoma AJCC v6 and v7

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (from AJCC 6th and 7th Eds.)


Pediatric Infectious Disorder

description: An infectious disorder that occurs during infancy, childhood, or adolescence.


Hypothalamic Cancer

description: A primary or metastatic malignant neoplasm that affects the hypothalamus.


Hypergranular promyelocytic leukemia

description: Acute Promyelocytic leukemia characterized by the presence of hypergranular promyelocytes and characteristic cells that contain bundles of Auer rods.


name: Non-Hodgkin's Lymphoma, Lymphoblastic (WF)


Stage IVB Gallbladder Cancer AJCC v8

description: Stage IVB includes: (Any T, N2, M0); (Any T, Any N, M1). N2: Metastases to four or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Locally Advanced Bladder Small Cell Neuroendocrine Carcinoma

description: A bladder small cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Primary cutaneous CD30 antigen positive T-cell lymphoproliferative disorder

description: A spectrum of lymphoproliferative disorders characterized by CD30 (Ki-1)-positive cutaneous T-cell infiltrates. The two ends of the spectrum include lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma.


name: Localized Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: An undifferentiated high grade pleomorphic sarcoma of bone that occurs in childhood and has not spread to other anatomic sites.


name: Locally Advanced Pancreatic Neuroendocrine Carcinoma

description: A pancreatic neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Unresectable Oligodendroglioma

description: An oligodendroglioma that is not amenable to surgical resection.


name: Stage IA Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of a single lymph node region or involvement of a single extra-lymphatic organ or site, without lymph node involvement. No constitutional symptoms are recorded. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Yolk Sac Tumor with Somatic-Type Malignancy

description: A yolk sac tumor that is characterized by morphologic transformation to somatic-type malignancy. The somatic-type malignant component most often is sarcomatous or carcinomatous.


name: Clear Cell Tumor with Melanocytic Differentiation and MITF-CREM Translocation

description: A MITF pathway-activated melanocytic tumor characterized by a cytogenetic translocation between MITF and CREM genes that results in MITF-CREM gene fusion. It presents as a single non-pigmented cutaneous nodule in the distal extremities. It is composed of large cells with clear cytoplasm that exhibit melanocytic differentiation and proliferate in the dermis without an intraepidermal component. Extension in the subcutaneous tissue is frequently seen. The neoplastic cells exhibit atypical features, including nuclear enlargement and hyperchromasia, irregular nuclear borders, and enlarged nucleolus. Mitotic activity is prominent. The biologic potential of this tumor is unknown.


Intraepithelial Melanocytic Hyperplasia

description: A hyperplasia of the intraepithelial melanocytes.


name: FIGO Stage IVC Gestational Trophoblastic Tumor


Childhood Gastric Carcinoma

description: A rare carcinoma of the stomach that occurs during childhood.


Stage IV Gallbladder Cancer AJCC v6

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.)


name: Stage y-I Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Tumor limited to kidney and completely resected. Renal capsule may be infiltrated by tumor, but tumor does not reach the outer surface. Tumor may protrude or bulge into the pelvic system or ureter but does not infiltrate. Vessel of renal sinus not involved. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Native valve endocarditis

description: Endocarditis affecting a native valve of the heart.


Benign germ cell neoplasm

description: A germ cell tumor without evidence of atypia and metastatic potential.


Pleural Infection

description: An infectious process affecting the pleura.


Stage II Uterine Corpus Cancer

description: Stage II includes: T2, N0, M0.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  Endocervical glandular involvement only should be considered as Stage I and not as Stage II.  N0: No regional lymph node metastasis. M0: No distant metastasis.  This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Esophageal Hodgkin Lymphoma

description: A very rare Hodgkin lymphoma that arises from the esophagus.


Refractory Vaginal Carcinoma

description: Vaginal carcinoma that does not respond to treatment.


Verumontanum Mucosal Gland Hyperplasia

description: A benign microacinar proliferation occurring exclusively in the verumontanum and adjacent posterior urethra where the ejaculatory ducts and utricle empty into the urethra. Crystalloids and intraluminal mucin are usually absent, but; intraluminal corpora amylacea are often present. The lining epithelium typically consists of bland cuboidal to columnar luminal cells with underlying basal cells.


name: Unresectable Fallopian Tube Endometrioid Adenocarcinoma

description: Fallopian tube endometrioid adenocarcinoma that is not amenable to surgical resection.


name: Acute Myeloid Leukemia with t(1;17)(q42.3;q21.2); IRF2BP2-RARA

description: Acute myeloid leukemia with variant RARA rearrangement associated with t(1;17)(q42.3;q21.2) resulting in IRF2BP2-RARA fusion protein expression.


name: Recurrent Adult Diffuse Large Cell Lymphoma

description: The reemergence of adult diffuse large cell lymphoma after a period of remission.


Benign Anal Granular Cell Tumor

description: A granular cell tumor that arises from the anus and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Acquired Facial Nerve Palsy

description: A condition characterized by reduced or absent movement of the ipsilateral face as a consequence of an injury to the seventh cranial nerve that has occurred after birth.


Unresectable Fibrosarcoma

description: A fibrosarcoma that is not amenable to surgical resection.


name: Beta Thalassemia Plus Structural Variants

description: A heterozygous state in which a person has a mutation in a beta globin allele causing beta thalassemia, together with other structural variants in the other allele.


Esthesioneurocytoma

description: A rare benign neuroectodermal tumor originating from olfactory receptor cells in the nasal cavity. Microscopically, it is characterized by the absence of malignant characteristics and the absence of rosettes formation.


Recurrent Primary Amyloidosis

description: The reemergence of primary amyloidosis after a period of remission.


Metastatic urothelial carcinoma

description: A carcinoma that arises from the urothelium and has spread from its original site of growth to another anatomic site.


Metastatic transitional cell carcinoma

description: A carcinoma that arises from transitional cells and has spread from its original site of growth to another anatomic site.


name: Localized Childhood Malignant Bone Neoplasm by Toronto Guidelines v2

description: Tumor confined to the area of origin including the regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Non-Neoplastic Peritoneal Disorder

description: A non-neoplastic disorder that affects the peritoneum. Representative examples include peritonitis and panniculitis.


Inherited neuropathies

description: A hereditary disorder that affects the sensory and/or motor nerves or the autonomic nerves.


name: Pathologic Stage IIIA Merkel Cell Carcinoma AJCC v8

description: Stage IIIA includes: (T1-4, N1a(sn) or N1a, M0); (T0, N1b, M0). T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1a(sn): Clinically occult regional lymph node metastasis identified only by sentinel lymph node biopsy. N1a: Clinically occult regional lymph node metastasis following lymph node dissection. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Esophageal Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The Ki-67 index is higher than 20%.


Advanced Malignant Germ Cell Tumor

description: A malignant germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Endometrial Carcinoma

description: Endometrial carcinoma that is not amenable to surgical resection.


name: intraductal papillary-mucinous neoplasm of pancreas with moderate dysplasia

description: A non-invasive pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that exhibit nuclear stratification, loss of polarity, and crowding.  There is moderate nuclear hyperchromasia.


Aplastic anemia due to infection

description: Aplastic anemia caused by an infection.


name: Schizoaffective disorder, depressive type

description: Schizoaffective disorder with episodes of depression only.


name: Esophageal High Grade Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal mucosa.  It includes lesions termed moderate dysplasia, and carcinoma in situ (severe dysplasia).  (WHO, 2000)


name: Advanced Primary Malignant Brain Neoplasm

description: A malignant neoplasm that arises from the brain and has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage IIIB Fallopian Tube Cancer AJCC v7

description: Stage IIIB includes: T3b, N0, M0.  T3b: Macroscopic peritoneal metastasis outside the pelvis 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Pathologic Stage I Esophageal Adenocarcinoma AJCC v8

description: Stage I includes: IA: (T1a, N0, M0, G1); (T1a, N0, M0, GX); IB: (T1a, N0, M0, G2); (T1b, N0, M0, G1-2); (T1b, N0, M0, GX); IC: (T1, N0, M0, G3); (T2, N0, M0, G1-2). T1a: Tumor invades the lamina propria or muscularis mucosae. T1b: Tumor invades the submucosa. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. G2: Moderately differentiated. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Neoplasm by Special Category

description: A neoplasm defined by its unique characteristic as they apply to clinical presentation and course, morphologic patterns, frequency, and/or age distribution.


Localized Gastric Carcinoma

description: A carcinoma that arises from the stomach and has not spread to other anatomic sites.


Uterine Ligament Wolffian Tumor

description: An epithelial neoplasm of Wolffian (mesonephric) origin arising from a uterine ligament. Most tumors behave in a benign fashion.


Transient Hyperinsulinism

description: Hyperinsulinism that resolves spontaneously. This is the most common cause of neonatal hypoglycemia.


Recurrent Malignant Solid Neoplasm

description: A malignant solid neoplasm that has recurred after a period of remission.


Sinusoidal hemangioma

description: A rare hemangioma occurring mainly in middle-aged adults. The most common location is in the trunk. The lesions are small, asymptomatic, and bluish. They are composed of irregular, dilated, congested thin-walled vascular channels with scant smooth muscle in a sinusoidal or sieve-like pattern. (WHO 2018)


Stage IB Cervical Cancer AJCC v9

description: Stage IB includes: T1b, N0, M0. T1b: Tumor with measured deepest invasion more than 5 mm (greater than FIGO stage IA); lesion limited to the cervix uteri with size measured by maximum tumor diameter. Note: The involvement of vascular/lymphatic spaces should not change the staging. The lateral extent of the lesion is no longer considered. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Verruca Plana

description: A wart characterized by the presence of flat-topped cutaneous papules. It is caused by human papillomavirus. It most commonly affects children and usually arises on the face, hands, and shins.


name: Stage IVB Cervical Cancer AJCC v6 and v7

description: Stage IVB includes: Any T, Any N, MI. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Stage IIIC Gastric Cancer AJCC v7

description: Stage IIIC includes: (T4b, N2, M0); (T4b, N3, M0); (T4a, N3, M0).  T4a: Tumor invades serosa (visceral peritoneum).  T4b: Tumor invades adjacent structures. N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


name: Metastatic Pancreatic Ductal Adenocarcinoma

description: An adenocarcinoma that arises from the exocrine pancreatic ducts and has metastasized to other anatomic sites.


Bilateral cataracts (disorder)

description: Partial or complete opacity of the crystalline lens of both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.)


name: Hematologic Malignancy-Associated Skin Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the skin in a patient with a history of hematologic malignancy, usually non-Hodgkin lymphoma or chronic lymphocytic leukemia.


name: Metastatic Carcinoma to the Uterine Cervix

description: A carcinoma that has spread to the cervix from another anatomic site.


description: A high grade poorly differentiated carcinoma arising from the digestive system.  It is composed of small or large neoplastic cells that express immunohistochemical evidence of neuroendocrine differentiation.  There is marked nuclear atypia, necrosis, and more than 20 mitoses per 10 HPF.


Nevus of Female Genitalia

description: A nevus that arises from the female genital organs. This category includes congenital nevus, acquired nevus, dysplastic nevus, blue nevus, and atypical melanocytic nevus of the genital type.


Pseudoporphyria

description: A drug-induced photodermatosis characterized by skin fragility, erythema, and the appearance of tense bullae, erosions and scarring in the absence of abnormalities in porphyrin metabolism.


name: Acute Myocardial Injury with Type I Myocardial Infarction Related to COVID-19

description: Acute myocardial injury with clinical presentation suggestive of type I myocardial infarction with detection of a rise or fall of cardiac troponin values with at least one value above the 99th percentile upper reference limit and with at least 1 of the following: 1. Symptoms of acute myocardial ischemia; 2. New ischemic ECG changes; 3. Development of pathological Q waves; 4. Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischemic etiology; 5. Identification of a coronary thrombus by angiography including intracoronary imaging or by autopsy, occurring in a patient with probable or confirmed acute COVID-19.


description: Intraepithelial neoplasia of the penis or vulva. It usually presents as a solitary white or pink macule or plaque that may be slightly elevated. A background of long-standing lichen sclerosus is often present.


Ectromelia

description: A congenital defect characterized by the absence or hypoplasia of one or more extremities.


Acute Bacterial Prostatitis

description: An acute infection of the prostate gland caused by bacteria, most often Escherichia coli, Proteus mirabilis, Klebsiella, and Pseudomonas aeruginosa. Signs and symptoms include fever, lower back pain, urinary frequency, and painful urination.  The urinalysis reveals the presence of white cells.  Risk factors include intraprostatic ductal reflux, phimosis, urinary tract infections, and unprotected anal intercourse.


name: Stage IIIC1 Uterine Corpus Cancer AJCC v8

description: Stage IIIC1 includes: T1-T3, N1/N1mi/N1a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N1: Regional lymph node metastasis to pelvic lymph nodes. N1mi: Regional lymph node metastasis (greater than 0.2 mm but nor greater than 2.0 mm in diameter) to pelvic lymph nodes. N1a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to pelvic lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Refractory Malignant Neoplasm of Multiple Primary Sites

description: Malignant neoplasm of multiple primary sites that is resistant to treatment.


Urethral Melanoma

description: A rare melanoma that arises from the urethral mucosa.


name: Refractory Invasive Pulmonary Aspergillosis

description: Invasive pulmonary aspergillosis that is resistant to treatment.


Skin Nodulocystic Basal Cell Carcinoma

description: A nodular basal cell carcinoma composed of solid and cystic areas.


Thoracotomy Scar

description: Replacement of destroyed tissue by fibrous tissue due to a surgical procedure where an incision was made into the chest wall to the left or to the right of the midline.


P2 Hydronephrosis

description: Postnatal Hydronephrosis with the following clinical findings: 1) APRPD is greater than or equal to 15 mm, 2) the calyces may be dilated centrally and peripherally, 3) or a dilated ureter is visible, 4) the parenchymal thickness and appearance is normal, and 5) the bladder is normal. Cases in which there is peripheral calyceal dilation but the APRPD is less than 15 mm are classified as UTD P2. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


name: Prostatic Intraepithelial Neoplasia-Like Adenocarcinoma

description: A rare subtype of prostate acinar adenocarcinoma that morphologically resembles high-grade prostatic intraepithelial neoplasia. It is characterized by the presence of large malignant glands lined with pseudostratified epithelium. It is graded as Gleason score 3+3=6.


name: Resectable Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that is amenable to surgical resection.


name: Stage I Gastric Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Cervical Mesonephric Remnants and Hyperplasia

description: The presence of embryonic remnants of mesonephric ducts in the cervix and their benign hyperplastic proliferations.


Glucagonoma, malignant

description: A glucagon-producing neuroendocrine tumor arising from the alpha cells of the pancreas.  It may be associated with necrolytic erythema migrans, diarrhea, diabetes, glossitis, weight loss, malabsorption, and anemia.  It displays vascular invasion and metastasizes to other anatomic sites.


name: Benign Osteoclastic Giant Cell-Rich Tumor of Bone

description: A giant cell tumor that arises from the bone and is characterized by the absence of local aggression and lack of metastatic potential.


Neonatal rickets

description: Rickets that usually affects premature infants. Factors that contribute to the development of neonatal rickets include calcium, phosphorus, or calciferol deficiency. It manifests with spontaneous fractures, respiratory distress, and growth developmental delays.


name: Unresectable Pancreatic Ductal Adenocarcinoma

description: Pancreatic ductal adenocarcinoma that is not amenable to surgical resection.


Recurrent Acute Myeloid Leukemia

description: The reemergence of acute myeloid leukemia after a period of remission.


Surfactant Protein A Deficiency

description: Deficiency of surfactant protein A. When present in normal amounts, this protein protects the lungs against a variety of bacteria, viruses, and fungi.


Recurrent Plasma Cell Neoplasm

description: The reemergence of a plasma cell neoplasm after a period of remission.


Prostate Paraganglioma

description: A paraganglioma that affects the prostate gland.


name: Adenoma of the Retinal Pigment Epithelium

description: A benign neoplasm that arises from the retinal pigment epithelium. It consists of cords and tubules of variably pigmented proliferating retinal pigment epithelium cells, separated by fibrous stroma. Malignant transformation is rare. (WHO 2018)


Neonatal Herpes Simplex Infection

description: Infection in the first month of life caused by the Herpes simplex virus.


name: Low Grade Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth.


Leukemia, Myeloid, Chronic-Phase

description: A phase of chronic myeloid leukemia, BCR-ABL1 positive in which the peripheral blood smear shows leukocytosis with neutrophils in different stages of maturation, less than 2% blasts, and normal or increased platelet count. Most patients have mild anemia. The bone marrow is hypercellular due to increased numbers of neutrophils and their precursors, and blasts usually account for fewer than 5% of the marrow cells. Megakaryocytes are smaller than normal and have hypolobated nuclei. The spleen is enlarged due to infiltration of the cords of the red pulp by granulocytes.


Neuroendocrine carcinoma of the bladder

description: A malignant, high grade neuroendocrine neoplasm that arises from the bladder. This category includes small cell and large cell neuroendocrine carcinoma.


Drug Resistant Epilepsy

description: Epilepsy that is refractory to treatment.


name: Stage IIIC Esophageal Adenocarcinoma AJCC v7

description: Stage IIIC includes: (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Recurrent WHO Grade 3 Glioma

description: The reemergence of a WHO grade III glioma after a period of remission.


Advanced Adenoid Cystic Carcinoma

description: Adenoid cystic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Lacrimal Drainage System Lymphoepithelial Carcinoma

description: A rare nonkeratinizing squamous cell carcinoma that arises from the lacrimal sac or nasolacrimal duct. It is characterized by the presence of large cells with vesicular nuclei and prominent nucleoli, a syncytial growth pattern, and a lymphoplasmacytic infiltrate.


Thrombosis of abdominal aorta

description: Formation of blood clot in the lumen of the abdominal aorta. It may lead to severe abdominal pain and ischemic necrosis of the intestine.


Stage IIIA Cervical Cancer FIGO 2018

description: Cervical carcinoma that involves the lower third of the vagina, with no extension to the pelvic wall. (FIGO 2018)


Acquired factor IX deficiency disease

description: An acquired coagulation disorder characterized by the partial or complete absence of factor IX activity in the blood.


name: Refractory Fallopian Tube Adenocarcinoma

description: Fallopian tube adenocarcinoma that is resistant to treatment.


name: Recurrent Pineal Parenchymal Cell Neoplasm

description: The reemergence of pineal parenchymal cell neoplasm after a period of remission.


Ureteric fistula

description: An abnormal communication between the ureter and another organ or anatomic site.


name: Osteoarthritis with Mild Chondrodysplasia

description: An autosomal dominant condition caused by mutation(s) in the COL2A1 gene, encoding collagen alpha-1(II) chain. It is characterized by osteoarthritis and mild chondrodysplasia.


Broad Ligament Serous Cystadenofibroma

description: A rare serous cystadenofibroma arising from the broad ligament.


FNCLCC Sarcoma Grade 3

description: A sarcoma with a total score of 6 or higher according to the FNCLCC guidelines.


Plexiform Spindle Cell Melanocytoma

description: A subtype of WNT-activated deep penetrating/plexiform melanocytoma (nevus). It is characterized by the proliferation of neoplastic melanocytes in the upper dermis, forming a plexiform pattern.


name: Male Reproductive System Precancerous Condition

description: A premalignant pathologic process arising from an organ of the male reproductive system.  It is characterized by cellular atypia and/or dysplasia but does not show morphologic evidence of stromal invasion at the time of diagnosis.  Representative examples include prostatic intraepithelial neoplasia, giant condyloma acuminatum of the penis, and penile intraepithelial neoplasia.


name: Unresectable Ampulla of Vater Adenocarcinoma

description: Adenocarcinoma that arises from the ampulla of Vater and is not amenable to surgical resection.


Metastatic Bone Sarcoma

description: Bone sarcoma that has spread from the original site of growth to another anatomic site.


name: Hyperplasia of Brunner glands of duodenum

description: A rare hyperplastic lesion of Brunner's gland in the duodenum. Although it is usually asymptomatic and discovered incidentally during upper gastrointestinal endoscopy, it may cause hemorrhage.


name: Stage IVA Oral Cavity Verrucous Carcinoma


name: B-Cell Proliferation of Uncertain Malignant Potential

description: A B-cell lymphoproliferative disorder with uncertain malignant potential. The representative example of this category is lymphomatoid granulomatosis.


Refractory Vulvar Carcinoma

description: Vulvar carcinoma that does not respond to treatment.


Non-Neoplastic Musculoskeletal Disorder

description: A non-neoplastic disorder that affects muscles and bones.


lymphomatoid papulosis, type C

description: A variant of lymphomatoid papulosis characterized clinically by regressing skin papules, and morphologically by features resembling anaplastic large cell lymphoma.


description: Ovarian or testicular dysfunction associated with high levels of gonadotropins, that is present at birth.


name: Chronic Phase Chronic Myeloid Leukemia, Philadelphia Chromosome Positive, BCR-ABL1 Positive

description: A phase of chronic myeloid leukemia, Philadelphia chromosome positive, BCR-ABL1 positive in which the peripheral blood smear shows leukocytosis with neutrophils in different stages of maturation, less than 2% blasts, and normal or increased platelet count. Most patients have mild anemia. The bone marrow is hypercellular due to increased numbers of neutrophils and their precursors, and blasts usually account for fewer than 5% of the marrow cells. Megakaryocytes are smaller than normal and have hypolobated nuclei. The spleen is enlarged due to infiltration of the cords of the red pulp by granulocytes.


name: Recurrent Ampulla of Vater Adenocarcinoma

description: The reemergence of ampulla of Vater adenocarcinoma after a period of remission.


Congenital Cystic Hygroma

description: A congenital lymphatic malformation usually arising from the neck and characterized by cystic dilation of the lymphatic vessels.


Adenocarcinoma endometrial metastatic

description: An adenocarcinoma which originated in the endometrium and has spread to another anatomic site.


Seminal Versicle Carcinoma

description: A carcinoma that arises from the seminal vesicle.


name: Refractory Acute Myeloid Leukemia Not Otherwise Specified

description: Acute myeloid leukemia not otherwise specified that does not respond to treatment.


name: Recurrent Monomorphic Post-Transplant Lymphoproliferative Disorder

description: The reemergence of monomorphic post-transplant lymphoproliferative disorder after a period of remission.


description: An exceedingly rare adenocarcinoma that arises from the endometrium and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage.


Stage IB Gastric Carcinoma

description: Stage IB includes: (T2, N0, M0); (T1, N1, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Female urinary-genital tract fistula

description: An abnormal connection between the urinary system and the genitals in a female.


description: An alveolar rhabdomyosarcoma characterized by the absence of chromosomal translocation t(1;13)(p36;q14) or t(2;13)(q35;q14) and therefore the absence of PAX7-FOXO1 or PAX3-FOXO1 gene fusion.


Primary Malignant Pelvic Neoplasm

description: A malignant neoplasm that arises from the organs and structures of the pelvis.


Severe Cardiac Valve Regurgitation

description: Evidence of severe retrograde blood flow through the valve(s) of the heart. (ACC)


name: FIGO Grade 1 Endometrial Mucinous Adenocarcinoma

description: A primary mucinous adenocarcinoma of the endometrium that contains equal to or less than 5% non-squamous solid areas.


name: Mixed Cellularity Classic Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for mixed cellularity classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Junctional Spitz Nevus

description: A Spitz nevus characterized by the presence of a junctional melanocytic component without involvement of the dermis.


Stage III Urethral Cancer AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0); (T3, N1, M0). T1: For male penile urethra and female urethra: Tumor invades subepithelial connective tissue. For prostatic urethra: Tumor invades urethral subepithelial connective tissue immediately underlying the urothelium. T2: For male penile urethra and female urethra: Tumor invades any of the following: corpus spongiosum, periurethral muscle. For prostatic urethra: Tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts. T3: For male penile urethra and female urethra: Tumor invades any of the following: corpus cavernosum, anterior vagina. For prostatic urethra: Tumor invades the periprostatic fat. N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIA Appendix Carcinoma AJCC v8

description: Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. M0: No distant metastasis. (AJCC 8th ed.)


name: clear cell adenocarcinoma of gallbladder

description: A rare morphologic variant of gallbladder adenocarcinoma composed of malignant glandular epithelium with a predominance of glycogen rich clear cells.  The cells display hyperchromic nuclei and well-defined cytoplasmic borders.


Fetal Neurodevelopmental Disorder

description: A fetal affliction that has a neurological basis and manifests as a developmental disability.


Stage I Vulvar Cancer

description: Stage I includes: T1, N0, M0. T1: Invasive vulvar cancer confined to the vulva or perineum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: T-Cell Large Granular Lymphocyte Leukemia Expressing the T-Cell Receptor Gamma-Delta

description: An uncommon variant of T-cell large granular lymphocyte leukemia expressing the gamma-delta T-cell receptor. Approximately 60% of these cases are CD8-positive and the remainder are CD4/CD8-negative.


Unresectable Low Grade Glioma

description: Low grade glioma that is not amenable to surgical removal.


Stage III Bone Cancer AJCC v8

description: Stage III includes: T3, N0, M0, G2 or G3. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


Nevoid Melanoma

description: A rare variant of cutaneous melanoma occurring mostly in adults in their fifth decade. Morphologically it resembles an ordinary compound or dermal nevus.


Stage I Bone Cancer AJCC v7

description: Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Metastatic malignant neoplasm to retina

description: A malignant neoplasm that has spread to the retina from another anatomic site.


Stage IVB Uterine Corpus Cancer AJCC v7

description: Stage IVB includes: Any T, Any N, M1.  M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, or lung, liver, or bone.  It excludes metastasis to para-aortic lymph nodes, vagina, pelvic serosa, or adnexa). This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Stage IB3 Cervical Cancer FIGO 2018

description: Invasive cervical carcinoma equal or more than 4 cm in greatest dimension. (FIGO 2018)


Cutaneous Mature B-Cell Neoplasm

description: A mature B-cell neoplasm that affects the skin.


Prostate Melanoma

description: An exceptionally rare melanoma arising from the prostate gland.


Deep Lipoma

description: A benign well-circumscribed tumor, composed of mature adipocytes, that arises within deep soft tissues.


Craniofacial Fibrous Dysplasia

description: Fibrous dysplasia affecting the craniofacial bones.


name: Stage III Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Residual tumor or nonhematogenous metastases confined to abdomen. Involved abdominal nodes. Peritoneal contamination or tumor implant. Tumor spillage of any degree occurring before or during surgery. Gross residual tumor in abdomen. Biopsy of tumor (including fine-needle aspiration) prior to removal of kidney. Resection margins involved by tumor. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Neonatal Spell

description: Cardiorespiratory events that are characterized by variable combinations of cessation of breathing, decrease in blood oxygen saturation, and decreased heart rate.


Stage IIA Esophagus Carcinoma

description: Stage IIA includes: For squamous cell carcinoma: (T2-3, N0, M0, G1, GX, Tumor location: Upper, middle); (T2-3, N0, M0, G2-3, Tumor location: Lower, X).  For adenocarcinoma: (T2, N0, M0, G3).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Leukopenia neonatal

description: Leukopenia that occurs in the neonatal period.


Acute lymphoblastic leukemia recurrent

description: The reemergence of acute lymphoblastic leukemia after a period of remission.


name: Unresectable Small Cell Neuroendocrine Carcinoma

description: Small cell neuroendocrine carcinoma that is not amenable to surgical resection.


Pancreatic intraepithelial neoplasia

description: A pre-cancerous, non-invasive pancreatic epithelial neoplasm that arises from and is confined to the pancreatic ducts.  It is a papillary or flat neoplasm that usually measures less than 5 mm in diameter.


Esophageal Cancer by AJCC v8 Stage

description: A term that refers to the staging of esophageal carcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Stage IIIB Merkel Cell Carcinoma AJCC v7

description: Stage IIIB includes: Any T, N1b/N2, M0.  N1b: Macrometastasis in regional lymph nodes.  N2: In transit metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Recurrent Myeloproliferative Neoplasm

description: The reemergence of a myeloproliferative neoplasm after a period of remission.


Sexual Aversion Disorder

description: A disorder characterized by recurrent or persistent extreme aversion to, and avoidance of, all genital contact with a sexual partner. The aversion to sexual contact is not attributable to another psychiatric disorder.


Gallbladder Tubular Carcinoid

description: A neuroendocrine tumor that arises from the gallbladder.  It does not show the morphologic characteristics of typical carcinoid tumors (neoplastic cells forming solid nests). In contrast, the tumor cells form small discrete tubules.


Benign Thymoma

description: A thymoma that is completely surrounded by a capsule, without evidence of capsular invasion, infiltration of the surrounding tissues, and metastases.


name: Cutaneous Melanoma by AJCC v8 Clinical Stage

description: A term that refers to the clinical staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system.


Childhood Osteoid Osteoma

description: An osteoid osteoma that occurs during childhood.


Stage IA Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring equal or less than 5 mm in depth and equal or less than 7 mm in width. (FIGO 2009)


Primary Valvular Disorder

description: Heart disease that is primarily due to a valvular defect or abnormality. Valve disease that is felt to be significant but does not fulfill the definition for primary valvular heat disease is considered contributory valvular heart disease.


Merkel Cell Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v7 classification system.


name: Childhood Benign Nervous System Neoplasm

description: A childhood neoplasm that arises from the nervous system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Thrombosis of vena cava

description: The formation of a thrombus in the vena cava.


name: Pelvic Undifferentiated High Grade Pleomorphic Sarcoma

description: Undifferentiated high grade pleomorphic sarcoma  involving the bones of the pelvis.


Marasmic kwashiorkor

description: Evidence of marasmic kwashiorkor.


Renal hemangioma

description: A rare hemangioma arising from the kidney.


name: FIGO Grade 2 Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma exhibiting 6-50% solid non-glandular, non-squamous growth.


name: Recurrent Malignant Urinary System Neoplasm

description: Reemergence of a malignant urinary system neoplasm after a period of remission.


name: Stage I Esophageal Adenocarcinoma AJCC v7

description: Stage I includes: IA (T1, N0, M0, G1-2, X); IB (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated.  G3: Poorly differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


name: Acute Myocardial Injury without Ischemia, Heart Failure, Ventricular Dysfunction, or Myocarditis Related to COVID-19

description: Acute myocardial injury, without evidence of acute ischemia, heart failure, a newly reduced left or right ventricular ejection fraction, cardiogenic shock, or myocarditis in a patient with probable or confirmed acute COVID-19.


name: Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8

description: Stage IIIB includes: (T2, N2, M0, Any G); (T3, N1-2, M0, Any G); (T4a, N0-1, M0, Any G). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Advanced gastric carcinoma

description: Gastric carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment.


Refractory Dedifferentiated Liposarcoma

description: Dedifferentiated liposarcoma that does not respond to treatment.


name: Unresectable Prostate Small Cell Neuroendocrine Carcinoma

description: Prostate small cell neuroendocrine carcinoma that is not amenable to surgical resection.


Cellulitis of pharynx

description: Cellulitis of the pharynx.


name: High grade cervical glandular intraepithelial neoplasia

description: Cervical glandular intraepithelial neoplasia characterized by the presence of severe dysplastic changes.


Mucocutaneous candidiasis

description: A fungal infection of the skin, nails, oral and vaginal mucosal sites caused by species of the genus Candida. It manifests with white discoloration of the tongue and swelling, redness, and tenderness of the nails.


Extrahepatic bile duct cancer stage III

description: Stage III includes: T4, Any N, M0.  T4: Tumor invades any of the following main portal vein or its branches bilaterally, common hepatic artery, or other adjacent structures, such as the colon, stomach, duodenum, or abdominal wall.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: Distant metastasis. (AJCC 6th ed.)


Aplastic bone marrow

description: Depletion of stem cells in the bone marrow that results in the lack of production of hematopoietic cells.


Cerebellar Paraganglioma

description: An extra-adrenal paraganglioma arising from the cerebellum.


name: Lymphoma by Lukes-Collins Classification (Antiquated)


name: High Grade Prostatic Intraepithelial Neoplasia

description: Prostatic intraepithelial neoplasia characterized by the presence of morphologically malignant cells lining the acini and ducts.  The malignant cells are enlarged, contain prominent nucleoli, and have increased nuclear/cytoplasmic ratio.  The malignant cells may grow within the ducts and acini in four architectural patterns: flat, tufting, micropapillary, and cribriform.  The presence of high grade prostatic intraepithelial neoplasia in needle biopsy is a risk factor for the subsequent detection of carcinoma on repeat biopsy.


Stage IV Ureter Cancer AJCC v7

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat.  N0: No regional lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  N1: Distant metastasis.  (AJCC 7th ed.)


name: Mixed Phenotype Acute Leukemia, B/T/Myeloid

description: A very rare mixed phenotype acute leukemia in which the blasts show evidence of B-cell, T-cell, and myeloid lineage but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation.


name: Bladder Urothelial Carcinoma, High Grade

description: Bladder urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


name: Post transplant Epstein-Barr virus associated lymphoproliferative disorder

description: A lymphoproliferative disorder that develops following organ transplantation and is associated with Epstein-Barr virus infection.


name: Stage I Lentigo Maligna Melanoma AJCC v7

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


name: Lacrimal Drainage System Mucoepidermoid Carcinoma

description: A carcinoma that arises from the lacrimal sac. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type.


Paratesticular tumor

description: A benign, borderline, or malignant neoplasm that affects the paratesticular structures.


name: Pathologic Stage III Merkel Cell Carcinoma AJCC v8

description: Stage III includes: IIIA: (T1-4, N1a(sn) or N1a, M0); (T0, N1b, M0); IIIB: (T1-4, N1b-3, M0). T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1a(sn): Clinically occult regional lymph node metastasis identified only by sentinel lymph node biopsy. N1a: Clinically occult regional lymph node metastasis following lymph node dissection. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. N2: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis. N3: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) with lymph node metastasis. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Hypothalamic Gangliocytoma

description: A tumor characterized by the presence of mature ganglion cells and neuronal differentiation, arising in the hypothalamus. It is often associated with the presence of pituitary gland adenomas. Symptoms include acromegaly and precocious puberty.


AIDS-Related Cervical Carcinoma

description: A carcinoma that arises from the cervix in a patient with acquired immunodeficiency syndrome.


Emaciation

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: An extreme loss of muscle and subcutaneous fat that is caused by malnutrition, and which results in a severely thin (emaciated) appearance.


P1 Hydronephrosis

description: Postnatal Hydronephrosis with the following clinical findings: 1) APRPD is 10 to less than 15 mm, 2) central calyceal dilation may be present, but peripheral calyceal dilation is considered to increase risk, 3) renal parenchyma should have normal thickness and appearance, 4) the ureter is not seen, and 5) the bladder is normal. If there is central calyceal dilation but the APRPD is less than 10 mm, it is still considered UTD P1. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


name: Acute Myeloid Leukemia with t(4;11)(q21.3;q23.3); AFF1-KMT2A

description: An acute myeloid leukemia associated with t(4;11)(q21.3;q23.3) resulting in AFF1-KMT2A gene fusion.


name: Psoriatic arthritis with distal interphalangeal joint involvement

description: Psoriatic arthritis with a particular pattern of involvement that affects the joints closest to the nails in both fingers and toes.


name: Hereditary Transthyretin Amyloid Cardiomyopathy

description: Transthyretin amyloid cardiomyopathy caused by mutation(s) in the TTR gene, encoding transthyretin.


Acute Myeloid Leukemia with BCOR-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of BCOR-RARA fusion protein.


Childhood Endocrine Neoplasm

description: A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ during childhood.


Stage IA Pancreatic Cancer AJCC v8

description: Stage IA includes: T1, N0, M0. T1: Tumor measuring 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Childhood Acute Lymphoblastic Leukemia CNS-Positive Toronto Guidelines v2

description: Clinical signs of CNS involvement or blasts in CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Substance Intoxication Delirium

description: A disorder characterized by the acute and sudden development of changes in attention, memory, language and/or perception that can be etiologically linked to the direct physiological consequences of substance intoxication.


name: Stage IIIA Uterine Corpus Cancer AJCC v7

description: Stage IIIA includes: T3a, N0, M0.  T3a: Tumor involves serosa and/or adnexa (direct extension or metastasis). N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


name: Cutaneous Hematopoietic and Lymphoid Cell Neoplasm

description: A neoplasm of hematopoietic and lymphoid cell origin that affects the skin.


name: Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: An undifferentiated high grade pleomorphic sarcoma that arises from the bone and occurs during adulthood.


Early Stage Malignant Skin Neoplasm

description: A stage term that refers to a malignant tumor confined to a limited area of the skin without lymph node or distant metastases.


name: Acute Myeloid Leukemia with SRSF2 Mutation

description: An acute myeloid leukemia associated with SRSF2 gene mutation.


Stage IV Vulvar Cancer AJCC v8

description: Stage IV includes: T1-T3, N3, M0-M1. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). T3: Tumor of any size with extension to any of the following: upper/proximal two-thirds of the urethra, upper/proximal two-thirds of the vagina, bladder mucosa, or rectal mucosa; or fixed to pelvic bone. N3: Fixed or ulcerated regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis (including pelvic lymph node metastasis). (from AJCC 8th Ed.)


Locally Advanced Lymphoma

description: Lymphoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: High Grade Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is high-grade.


Conditioned Insomnia

description: Insomnia that results from a developed tendency to not sleep well under particular conditions.


Broad Ligament Serous Cystadenoma

description: A rare serous cystadenoma arising from the broad ligament.


name: Refractory Non-Muscle Invasive Bladder Carcinoma

description: Non-muscle invasive bladder carcinoma that is resistant to treatment.


Childhood Dermal Nevus

description: A dermal nevus that occurs during childhood.


name: Adenocarcinoma in situ in villous adenoma

description: A non-invasive adenocarcinoma arising from a villous adenoma.


Childhood Gemistocytic Astrocytoma

description: A gemistocytic astrocytoma that occurs during childhood.


Vaginal Mesonephric Adenocarcinoma

description: Vaginal adenocarcinoma that derives from Wolffian duct remnants and shows mesonephric differentiation.


name: FIGO Stage IIB Gestational Trophoblastic Tumor


Adult Acquired Toxoplasmosis

description: Toxoplasmosis acquired in adulthood.


High Grade Sarcoma

description: A sarcoma with the morphologic features of a high-grade tumor and lack of cellular differentiation.


Locally Recurrent Malignant Neoplasm

description: The reemergence of a malignant neoplasm after a period of remission at the site of the original tumor or adjacent to it.


Pediatric Obesity

description: A condition in which a child's body mass index (BMI) falls at or above the 95th percentile based on the normative values for the age and sex of the reference population.


Cerebellar Glioblastoma

description: A glioblastoma that occurs in the cerebellum.


name: Acute Lymphoblastic Leukemia by ROSE Cluster

description: Unique gene expression-based patient cluster groups in high-risk B-precursor acute lymphoblastic leukemia determined by Recognition of Outliers by Sampling Ends (ROSE).


Bilateral Proliferative Retinopathy

description: Proliferative retinopathy occurring in both eyes.


Stage IVB Bone Cancer AJCC v7

description: Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N1: Regional lymph node metastasis.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


name: Cervix Intraepithelial Neoplasia Grade 3 AJCC v7

description: Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


name: Umbilical hernia without mention of obstruction or gangrene

description: The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the umbilicus, without mention of obstruction or necrosis of the herniated contents.


name: Locally Advanced Cervical Adenocarcinoma

description: A cervical adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Non-small cell carcinoma

description: A malignant epithelial neoplasm characterized by the absence of neoplastic small epithelial cells. A representative example is the lung non-small cell carcinoma.


Tumors Derived from Langerhans Cells

description: This category includes two main sub-groups, according to the degree of cytological atypia and clinical aggressiveness: Langerhans cell histiocytosis and Langerhans cell sarcoma. (WHO 2017)


Racial Melanosis

description: A benign conjunctival finding noted especially among darker pigmented individuals. While it is typically found perilimbally and bilaterally, it can also cover the conjunctivae extensively and may present asymmetrically. The flat, non-cystic pigmentation may increase in size with age. It is rare to have this finding evolve into conjunctival melanoma.


Broad Ligament Wolffian Tumor

description: An epithelial neoplasm of Wolffian (mesonephric) origin arising from the broad ligament. Most tumors behave in a benign fashion.


name: Pathologic Stage IIID Cutaneous Melanoma AJCC v8

description: Stage IIID includes: T4b, N3a/b/c, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Recurrent Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA

description: The reemergence of acute promyelocytic leukemia with t(15;17)(q24.1;q21.2); PML-RARA after a period of remission.


name: Stage M3 Childhood Ependymoma by Toronto Guidelines v2

description: Visible metastasis in spine or visible metastasis in cervicomedullary junction. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Midgut Neuroendocrine Tumor

description: A neuroendocrine tumor that arises from the jejunum, ileum, proximal colon, or appendix.


name: Idiopathic Dysplasia of Uncertain Significance

description: Prominent hematopoietic cell dysplasia with mild or absent cytopenia. It may progress to an overt myelodysplastic syndrome or other myeloid neoplasms such as acute myeloid leukemia, myeloproliferative neoplasm, or mast cell disorder.


name: Schizophrenia and other psychotic disorders

description: A category of psychiatric disorders characterized by the presence of psychotic symptoms such as delusions or hallucinations or negative symptoms such as affective flattening.


Tubal Hyperplasia

description: Benign proliferation of the fallopian tube epithelium.


name: acute combined systolic and diastolic congestive heart failure

description: Acute congestive heart failure due to reduced contractility of the left ventricle and which does not fill properly due to decreased compliance.


Abnormal Finding

description: A decision that an observation or result is outside the parameters considered normal.


Trichilemmal carcinoma

description: A rare malignant tumor arising from the outer hair sheath and infundibulum on the face. It is considered the malignant counterpart of tricholemmoma. Complete surgical excision is required.


Stage IIIB Vulvar Cancer AJCC v7

description: Stage IIIB includes: (T1/T2, N2a/N2b, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N2a: Vulvar cancer with three or more lymph node metastases each measuring 5 mm or less.  N2b: Vulvar cancer with two or more lymph node metastases measuring 5 mm or greater.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Low Grade Gastric Intraepithelial Neoplasia

description: A gastric intraepithelial lesion characterized by the presence of neoplastic cells with mild cytologic atypia, mild architectural changes, and low number of mitotic figures.


name: Anaplastic Large Cell Lymphoma, Lymphomatoid Papulosis-Like Histology

description: An anaplastic large cell lymphoma characterized by the presence of histopathologic features reminiscent of lymphomatoid papulosis. These features include the presence of Hodgkin-like cells in a background of acute and chronic inflammation.


name: Hodgkin's disease, lymphocytic depletion of lymph nodes of multiple sites

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Adenocarcinoma of the prostate stage III

description: Stage III includes: T3a-b, N0, M0, Any PSA, Any Gleason.  cT3a: Tumor with extracapsular extension (unilateral or bilateral).  pT3a: Tumor with extraprostatic extension or microscopic invasion of bladder neck.  T3b: Tumor invades seminal vesicle(s).  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Unresectable Ampulla of Vater Carcinoma

description: Carcinoma that arises from the ampulla of Vater and is not amenable to surgical resection.


Fistula of the female genital organs

description: An abnormal communication between a female reproductive system organ and another organ or cavity.


Carcinoma Metastatic to the Skin

description: A carcinoma that has spread to the skin from its original site of gowth.


Testicular Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the testis.  Representative examples include infection, torsion, and infarction.


name: Advanced Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Metastatic Melanoma

description: Metastatic melanoma that is resistant to treatment.


Stage IV Bone Sarcoma AJCC v7

description: Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Pancreatic Hepatoid Adenocarcinoma

description: A rare adenocarcinoma that arises from the pancreas.  It is characterized by marked hepatocellular differentiation.


Stage I Ampulla of Vater Cancer AJCC v8

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2, N0, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Acute Myeloid Leukemia with idic(X)(q13)

description: Acute myeloid leukemia associated with isodicentric chromosome Xq13 [idic(X)(q13)].


name: Non-Muscle Invasive Bladder Urothelial Carcinoma

description: An infiltrating urothelial carcinoma of the bladder that has not invaded into the bladder muscularis propria.


Non-Invasive Cribriform Carcinoma

description: A carcinoma characterized by the presence of a cribriform architectural pattern. There is no evidence of surrounding stromal invasion by the malignant cells.


name: Chronic Myelomonocytic Leukemia with Eosinophilia Associated with t(5;12)(q31;p12)

description: Chronic myelomonocytic leukemia characterized by the presence of eosinophilia, PDGFRB gene rearrangement, and t(5;12)(q31;p12).


name: Stage IVB Oral Cavity Verrucous Carcinoma


Stage IVA Gallbladder Cancer AJCC v8

description: Stage IVA includes: T4, N0-1, M0. T4: Tumor invading the main portal vein or hepatic artery or invading two or more extrahepatic organs or structures. N0: No regional lymph node metastasis. N1: Metastases to one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Multiple congenital anomalies

description: The presence of multiple congenital malformations in a patient.


name: Mitochondrial Uncoupling Protein 2 Hyperinsulinism

description: Hyperinsulinism due to mutation(s) in the gene UCP2, encoding mitochondrial uncoupling protein 2, which plays a role in attenuating insulin secretion.


Supratentorial Ependymoma

description: A circumscribed ependymoma that arises from the supratentorial region of the brain. The diagnosis of supratentorial ependymoma should be made either when genetic analysis did not reveal a fusion gene involving ZFTA or YAP1 genes (not elsewhere classified -NEC) or when the genetic analysis was unsuccessful or not reported (not otherwise specified-NOS).


Pediatric Disorder

description: A non-neoplastic or neoplastic disorder which occurs during infancy, childhood, or adolescence.


Non-Neoplastic Anorectal Disorder

description: A non-neoplastic disorder that affects the anus and rectum.


name: Columnar Cell Change of the Breast with Atypia

description: A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini.  The acini are lined by one or two layers of columnar epithelial cells.  Cytologic atypia is present.


Foregut Neuroendocrine Tumor G2

description: A neuroendocrine tumor grade 2 that arises from the esophagus, stomach, or duodenum.


Asymptomatic Inflammatory Prostatitis

description: Inflammation of the prostate gland that is not associated with any symptoms. It is characterized by the presence of inflammatory cells in the prostatic fluid.


name: Complete unbalanced atrioventricular canal defect

description: Atrioventricular septal defect in which there is usually a single dominant ventricle and a hypoplastic ventricle.


Refractory Cytomegalovirus Infection

description: A cytomegalovirus infection that is resistant to treatment.


Liver Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the liver. The Ki-67 index is higher than 20%.


name: AIDS-Related Diffuse Large Cell Lymphoma

description: A diffuse large cell lymphoma developing in an HIV positive patient.


name: Recurrent Low Grade Endometrial Endometrioid Adenocarcinoma

description: The reemergence of endometrial low-grade endometrioid adenocarcinoma after a period of remission.


name: Deletion of Chromosome 22 Associated Meningioma

description: A meningioma that is associated with deletion of chromosome 22.  This abnormality is the most consistent cytogenetic finding that is detected in meningiomas.


Stage IB Merkel Cell Carcinoma AJCC v7

description: Stage IB includes: T1, cN0, M0.  T1: Primary tumor equal or less than 2 cm in size.  cN0: No regional lymph node metastasis by clinical examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


name: Stage IV Ampulla of Vater Cancer AJCC v7

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis.  (from AJCC 7th Ed.)


Bone Schwannoma

description: A very rare schwannoma of the bone. It is often located in the mandible and is well circumscribed.


Esophageal dysplasia

description: A lesion that is characterized by architectural and cytologic abnormalities of the esophageal epithelium, and carries a predisposition for progression to invasive carcinoma.  Intraepithelial neoplasia (dysplasia) of the esophagus is graded as low or high grade.  In this two-tier system, severe dysplasia and carcinoma in situ are included under the rubric of high grade intraepithelial neoplasia and may have the same clinical implications.  (WHO, 2000)


Melanocytic matricoma

description: A rare benign pilar tumor with numerous intratumoral pigmented dendritic melanocytes. It typically affects elderly men. The most common location is the head and neck, followed by the trunk and the limbs. It manifests as a small, pigmented, purple or brownish-black papule or nodule. (WHO 2018)


Stage II Vaginal Cancer AJCC v6 and v7

description: Stage II includes: T2, N0, M0. T2: Tumor invades paravaginal tissues but not to pelvic wall.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Precursor T-lymphoblastic lymphoma/leukemia stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in a with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Childhood Malignant Solid Neoplasm

description: A malignant solid neoplasm that occurs during childhood.


Infant Acute Undifferentiated Leukemia

description: An acute undifferentiated leukemia that occurs in infancy.


Developmental delay

description: Failure to meet, or late achievement of developmental milestones.


Acute gastritis

description: Acute inflammation of the stomach.


name: Stage IIIA Ampulla of Vater Cancer AJCC v8

description: Stage IIIA includes: (T1a, N1, M0); (T1b, N1, M0); (T2, N1, M0); (T3a, N1, M0); (T3b, N1, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N1: Metastasis to one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Argentaffinoma

description: A carcinoid tumor that shows atypical characteristics and has borderline malignant potential.


Zonular dehiscence

description: Rupture of the fibrous strands connecting the ciliary body and the crystalline lens of the eye.


Sickle Beta 0 Thalassemia

description: A form of sickle cell thalassemia characterized by the absence of hemoglobin A. Patients usually have severe anemia identical to that seen in sickle cell disease.


Substance-Induced Sleep Disorder

description: A sleep disorder (insomnia, hypersomnia, or parasomnia) for which there is strong evidence that the disorder is etiologically linked to the direct physiological effects of a substance (i.e., a drug of abuse, a medication, or toxin exposure).


Unresectable Pancreatic Adenocarcinoma

description: Pancreatic adenocarcinoma that is not amenable to surgical resection.


name: Infant Acute Lymphoblastic Leukemia without KMT2A Rearrangement

description: An acute lymphoblastic leukemia without rearrangement of the KMT2A gene that occurs in infancy.


name: Myelodysplastic Syndrome, Not Otherwise Specified without Dysplasia

description: A premalignant hematologic condition characterized by cytopenia and absence of bone marrow dysplasia. There are less than 5% blasts in bone marrow and less than 2% blasts in peripheral blood.


Malposition of uterus

description: Orientation of the uterus in an unusual anatomic location or position.


Refractory acute myeloid leukemia

description: Acute myeloid leukemia that does not respond to treatment.


Stage III Fallopian Tube Cancer AJCC v8

description: Stage III includes: IIIA1: T1/2, N1, M0; IIIA2: T3a, N0/N1, M0; IIIB: T3b, N0/N1, M0; IIIC: T3c, N0/N1, M0. T1: Fallopian tube cancer with tumor limited to fallopian tube(s). T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. T3a: Fallopian tube cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. T3b: Fallopian tube cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. T3c: Fallopian tube cancer with macroscopic peritoneal metastasis beyond the pelvis more than 2 cm in greatest dimension with or without metastasis to the retroperitoneal lymph nodes (includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ). N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


name: Type II Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the coronary sinus.


Taste Disorders

description: Conditions characterized by an alteration in the ability to perceive taste.


name: Hepatocyte Nuclear Factor 4-Alpha Hyperinsulinism

description: Hyperinsulinism due to mutation(s) in the gene HNF4A, encoding the transcription factor hepatocyte nuclear factor 4-alpha. This condition may progress to diabetes later in life.


Cystine urolithiasis

description: Urolithiasis in which the composition of the stones is predominantly cystine.


name: Renal Pelvis and Ureter Cancer by AJCC v8 Stage

description: A term that refers to the staging of renal pelvis and ureter cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to renal pelvis and ureter urothelial (transitional cell) carcinoma, including histologic variants micropapillary and nested subtypes. It does not apply to renal cell carcinomas (are staged according to the classification for kidney), renal medullary carcinomas (are staged according to the classification for kidney), collecting duct carcinomas (are staged according to the classification for kidney),  lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and mesenchymal tumors (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs). (from AJCC 8th Ed.)


Megacystis - Megaureter

description: A condition characterized by a large capacity, thin-walled bladder and megaureter(s).


Condyloma Acuminatum with Dysplasia

description: Condyloma acuminatum that is associated with the presence of dysplastic epithelial changes.


Adenoma, Trabecular

description: A benign epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern.


Recurrent Adult Brain Neoplasm

description: The reemergence of brain neoplasm in adulthood after a period of remission.


Low Grade Mucinous Carcinoma Peritonei

description: A low-grade mucinous adenocarcinoma that has spread to the peritoneum.


Stage 0is Urethral Cancer AJCC v8

description: Stage 0is includes: Tis, N0, M0. Tis: For male penile urethra and female urethra: Carcinoma in situ. For prostatic urethra: Carcinoma in situ involving the prostatic urethra or periurethral or prostatic ducts without stromal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage I Ureter Cancer AJCC v7

description: Stage I includes: T1, N0, M0.  T1: Tumor invades subepithelial connective tissue. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Adenocarcinoma in villous adenoma

description: A non-invasive or invasive adenocarcinoma arising from a villous adenoma.


name: Advanced Anal Canal Squamous Cell Carcinoma

description: Anal canal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IB Osteosarcoma AJCC v7

description: Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


name: FIGO Stage IIIA Gestational Trophoblastic Tumor


name: Paratesticular Clear Cell Adenocarcinoma

description: An exceedingly rare adenocarcinoma that arises from the paratesticular structures. It is characterized by the presence of columnar, hobnail, and polygonal cells with clear cytoplasm.


Acquired Cataract

description: Cataract that results from the aging process, an injury, or as a manifestation of a systemic disorder.


Stage IIIC1 Cervical Cancer FIGO 2018

description: Cervical carcinoma with pelvic lymph node metastasis only. (FIGO 2018)


name: Recurrent Small Cell Neuroendocrine Carcinoma

description: The reemergence of small cell neuroendocrine carcinoma after a period of remission.


name: Invasive Plasmacytoid Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by the presence of malignant cells with plasmacytoid features.


Stage IIA Gastric Cancer AJCC v7

description: Stage IIA includes: (T3, N0, M0); (T2, N1, M0); (T1, N2, M0). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


name: Locally Advanced Adenoid Cystic Carcinoma

description: Adenoid cystic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Ampulla of Vater Hepatoid Adenocarcinoma

description: A very rare adenocarcinoma that arises from the ampulla of Vater.  It is usually of the intestinal type and is characterized by the presence of malignant polygonal cells with abundant eosinophilic cytoplasm resembling hepatocytes.


Stage IA Bone Sarcoma AJCC v7

description: Stage IA includes: T1, N0, M0, G1, G2, GX.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


name: Locally Advanced Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Bladder Endometrioid Adenocarcinoma

description: A rare bladder adenocarcinoma with the histologic characteristics of endometrioid adenocarcinoma of the endometrium.


Lymphoma stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Metastatic Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that has spread from its original site of growth to another anatomic site.


Appendix Tubular Carcinoid

description: A neuroendocrine tumor that arises from the appendix.  It does not show the morphologic characteristics of typical carcinoid tumors (neoplastic cells forming solid nests). In contrast, the tumor cells form small discrete tubules.


name: Merkel Cell Carcinoma by AJCC v8 Pathologic Stage

description: A term that refers to the pathologic staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v8 classification system.


Smoldering Systemic Mastocytosis

description: Slowly progressive systemic mastocytosis with uncertain prognosis. It is characterized by organomegaly and absence of aggressive disease.


Fibrolipoma

description: A benign well-circumscribed tumor composed of mature adipocytes, characterized by areas of abundant fibrous tissue.


Stage IIA Testicular Cancer AJCC v8

description: Stage IIA includes: (Any pT/TX, N1, M0, S0); (Any pT/TX, N1, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Childhood Benign Skin Melanocytic Nevus

description: A circumscribed proliferation of melanocytes in the skin that occurs during childhood. It is characterized by the absence of atypical or malignant cytological features, and absence of invasive features or metastatic potential.


name: Adult Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for adult Hodgkin lymphoma based on the Ann Arbor classification criteria.


Stage IVA Cervical Cancer AJCC v9

description: Stage IVA includes: T4, Any N, M0. T4: Tumor has involved (biopsy-proven) the mucosa of the bladder or rectum, or has spread to adjacent organs. M0: No distant metastasis. (from AJCC 9th Ed.)


Placental site nodule

description: A non-neoplastic trophoblastic disorder characterized by the presence of remnants of intermediate trophoblasts in the uterine cavity and infrequently the fallopian tube from a previous pregnancy.


Congenital anomaly of eyelid

description: The abnormal formation of the eyelid that is present at the time of birth.


name: Prostate Adenocarcinoma with Neuroendocrine Differentiation

description: An invasive prostate adenocarcinoma characterized by the presence of malignant cells that exhibit neuroendocrine differentiation.


Psychological Dependence

description: A behavioral pattern characterized by a craving for the mood-altering effects of a drug and an overwhelming preoccupation with obtaining and using the drug.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Children's Oncology Group (COG) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the Toronto childhood cancer staging guidelines v2, Children's Oncology Group (COG) protocol. It is based on findings at surgery for patients who have not received chemotherapy prior to surgery. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Congenital postural scoliosis

description: Abnormal sideways curvature of the spine that is present at birth.


Intestinal Stoma Prolapse

description: An intestinal stoma complication characterized by protrusion of the intestine above the abdominal surface.


Rhabdomyolysis Related to COVID-19

description: Rhabdomyolysis in a patient with probable or confirmed acute COVID-19.


Cellular Blue Nevus

description: A blue nevus characterized by a multinodular cellular infiltrate with a dumb-bell architecture occupying the reticular dermis. The cellular infiltrate often extends into the subcutaneous tissue. The cellular infiltrate is composed of spindle-shaped melanocytes with pale cytoplasm alternating with bundles of pigmented spindle-shaped melanocytes. In occasional cases an increased mitotic activity, focal necrosis, and nuclear pleomorphism may be seen. Such cases with atypical features may have an uncertain malignant potential.


Metastatic Carcinoma in the Peritoneum

description: A carcinoma that has spread to the peritoneum from an adjacent or distal anatomic site.


name: Clinical Stage IV Retinoblastoma AJCC v8

description: Stage IV includes: Any cT, Any N, cM1 or pM1, Any H. cM1: Distant metastasis without microscopic confirmation. pM1: Distant metastasis with microscopic confirmation. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


name: Refractory Rare Malignant Solid Neoplasm

description: A rare malignant solid neoplasm that is resistant to treatment.


name: Stage I Renal Pelvis and Ureter Cancer AJCC v7

description: Stage I includes: T1, N0, M0.  T1: Tumor invades subepithelial connective tissue. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Recurrent Endometrial Transitional Cell Carcinoma

description: The reemergence of endometrial transitional cell carcinoma after a period of remission.