name: Deacetylation of cohesin (Canis familiaris)


name: Resolution of sister chromatids (Canis familiaris)

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: Phosphorylation of cohesin by PLK1 at centromeres (Canis familiaris)


name: PLK1 phosphorylates FIRMM at S744 (Canis familiaris)


name: PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)


name: CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Canis familiaris)


name: Phosphorylation of cohesin by PLK1 at chromosomal arms (Canis familiaris)


name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Canis familiaris)


name: Resolution of Sister Chromatid Cohesion (Sus scrofa)

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: PPP1CC dephosphorylates PLK1 (Sus scrofa)


name: PLK1 phosphorylates FIRRM at S43 (Sus scrofa)


name: Phosphorylation of cohesin by PLK1 at centromeres (Sus scrofa)


name: PP2A-B56 dephosphorylates centromeric cohesin (Sus scrofa)


name: Resolution of sister chromatids (Sus scrofa)


name: PLK1 phosphorylates FIRMM at S744 (Sus scrofa)


name: Phosphorylation of cohesin by PLK1 at chromosomal arms (Sus scrofa)


name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Sus scrofa)


name: CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Sus scrofa)


name: Resolution of Sister Chromatid Cohesion (Danio rerio)


name: Phosphorylation of cohesin by PLK1 at chromosomal arms (Danio rerio)


name: PLK1 phosphorylates FIRMM at S744 (Danio rerio)


name: PLK1 phosphorylates FIRRM at S43 (Danio rerio)


name: CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Danio rerio)


name: Resolution of Sister Chromatid Cohesion (Xenopus tropicalis)


name: PPP1CC dephosphorylates PLK1 (Xenopus tropicalis)


name: Phosphorylation of cohesin by PLK1 at centromeres (Xenopus tropicalis)


name: CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Xenopus tropicalis)


name: Phosphorylation of cohesin by PLK1 at chromosomal arms (Xenopus tropicalis)


name: PP2A-B56 dephosphorylates centromeric cohesin (Xenopus tropicalis)


name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Xenopus tropicalis)


name: Kinetochore assembly (Xenopus tropicalis)


name: Resolution of Sister Chromatid Cohesion (Gallus gallus)


name: Deacetylation of cohesin (Gallus gallus)


name: Phosphorylation of cohesin by PLK1 at chromosomal arms (Gallus gallus)


name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Gallus gallus)


name: Phosphorylation of cohesin by PLK1 at centromeres (Gallus gallus)


name: PPP1CC dephosphorylates PLK1 (Gallus gallus)


name: CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Gallus gallus)


name: PLK1 phosphorylates FIRMM at S744 (Gallus gallus)


name: PLK1 phosphorylates FIRRM at S43 (Gallus gallus)


name: PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)


name: Resolution of Sister Chromatid Cohesion (Drosophila melanogaster)


name: PPP1CC dephosphorylates PLK1 (Drosophila melanogaster)


name: CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Drosophila melanogaster)


name: Phosphorylation of cohesin by PLK1 at chromosomal arms (Drosophila melanogaster)


name: Resolution of Sister Chromatid Cohesion (Caenorhabditis elegans)


name: CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Caenorhabditis elegans)


name: PPP1CC dephosphorylates PLK1 (Caenorhabditis elegans)


name: Phosphorylation of cohesin by PLK1 at chromosomal arms (Caenorhabditis elegans)


name: Resolution of Sister Chromatid Cohesion (Dictyostelium discoideum)


name: Phosphorylation of cohesin by PLK1 at chromosomal arms (Dictyostelium discoideum)


name: PPP1CC dephosphorylates PLK1 (Dictyostelium discoideum)


name: Deacetylation of cohesin (Dictyostelium discoideum)


name: Resolution of Sister Chromatid Cohesion (Schizosaccharomyces pombe)


name: Phosphorylation of cohesin by PLK1 at chromosomal arms (Schizosaccharomyces pombe)


name: PPP1CC dephosphorylates PLK1 (Schizosaccharomyces pombe)


name: Resolution of Sister Chromatid Cohesion (Saccharomyces cerevisiae)


name: Phosphorylation of cohesin by PLK1 at chromosomal arms (Saccharomyces cerevisiae)


name: PPP1CC dephosphorylates PLK1 (Saccharomyces cerevisiae)


name: Deacetylation of cohesin (Saccharomyces cerevisiae)


name: Resolution of Sister Chromatid Cohesion (Plasmodium falciparum)


name: PPP1CC dephosphorylates PLK1 (Plasmodium falciparum)


name: CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Bos taurus)


name: Condensation of Prophase Chromosomes (Bos taurus)


name: Condensin II complex binds H4K20me1-containing nucleosomes (Bos taurus)


name: CDK1 phosphorylates condensin II subunit NCAPD3 (Bos taurus)


name: MCPH1 sequesters condensin II (Bos taurus)


name: PHF8 demethylates histone H4K20me1 (Bos taurus)


name: PLK1 hyperphosphorylates Condensin II complex (Bos taurus)


name: PLK1 binds phosphorylated condensin II complex (Bos taurus)


name: SETD8 monomethylates histone H4 (Bos taurus)


name: Condensation of Prophase Chromosomes (Homo sapiens)


name: Condensin II-mediated condensation of prophase chromosomes (Homo sapiens)


name: PLK1 binds phosphorylated condensin II complex (Homo sapiens)


name: CDK1 phosphorylates condensin II subunit NCAPD3 (Homo sapiens)


name: PLK1 hyperphosphorylates Condensin II complex (Homo sapiens)


histone H4K20 demethylase activity

description: Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


name: SETD8 monomethylates histone H4 (Homo sapiens)


name: Condensin II complex binds H4K20me1-containing nucleosomes (Homo sapiens)


name: MCPH1 sequesters condensin II (Homo sapiens)


name: Condensation of Prophase Chromosomes (Mus musculus)


name: MCPH1 sequesters condensin II (Mus musculus)


name: PLK1 binds phosphorylated condensin II complex (Mus musculus)


name: PLK1 hyperphosphorylates Condensin II complex (Mus musculus)


name: CDK1 phosphorylates condensin II subunit NCAPD3 (Mus musculus)


name: Condensation of Prophase Chromosomes (Rattus norvegicus)


name: PLK1 binds phosphorylated condensin II complex (Rattus norvegicus)


name: SETD8 monomethylates histone H4 (Rattus norvegicus)


name: PHF8 demethylates histone H4K20me1 (Rattus norvegicus)


name: PLK1 hyperphosphorylates Condensin II complex (Rattus norvegicus)


name: MCPH1 sequesters condensin II (Rattus norvegicus)


name: CDK1 phosphorylates condensin II subunit NCAPD3 (Rattus norvegicus)


name: RB1 binds condensin II (Rattus norvegicus)


name: Condensation of Prophase Chromosomes (Canis familiaris)


name: CDK1 phosphorylates condensin II subunit NCAPD3 (Canis familiaris)


name: PLK1 binds phosphorylated condensin II complex (Canis familiaris)


name: PHF8 demethylates histone H4K20me1 (Canis familiaris)


name: MCPH1 sequesters condensin II (Canis familiaris)


name: PLK1 hyperphosphorylates Condensin II complex (Canis familiaris)


name: RB1 binds condensin II (Canis familiaris)


name: Condensation of Prophase Chromosomes (Sus scrofa)


name: SETD8 monomethylates histone H4 (Sus scrofa)


name: PLK1 binds phosphorylated condensin II complex (Sus scrofa)


name: CDK1 phosphorylates condensin II subunit NCAPD3 (Sus scrofa)


name: MCPH1 sequesters condensin II (Sus scrofa)


name: PHF8 demethylates histone H4K20me1 (Sus scrofa)


name: PLK1 hyperphosphorylates Condensin II complex (Sus scrofa)


name: Condensation of Prophase Chromosomes (Danio rerio)


name: PLK1 binds phosphorylated condensin II complex (Danio rerio)


name: PLK1 hyperphosphorylates Condensin II complex (Danio rerio)


name: SETD8 monomethylates histone H4 (Danio rerio)


name: PHF8 demethylates histone H4K20me1 (Danio rerio)


name: Condensin II complex binds H4K20me1-containing nucleosomes (Danio rerio)


name: CDK1 phosphorylates condensin II subunit NCAPD3 (Danio rerio)


name: Condensation of Prophase Chromosomes (Xenopus tropicalis)


name: SETD8 monomethylates histone H4 (Xenopus tropicalis)


name: PHF8 demethylates histone H4K20me1 (Xenopus tropicalis)


name: Condensation of Prophase Chromosomes (Gallus gallus)


name: PLK1 hyperphosphorylates Condensin II complex (Gallus gallus)


name: PHF8 demethylates histone H4K20me1 (Gallus gallus)


name: SETD8 monomethylates histone H4 (Gallus gallus)


name: Condensin II complex binds H4K20me1-containing nucleosomes (Gallus gallus)


name: PLK1 binds phosphorylated condensin II complex (Gallus gallus)


name: Condensation of Prophase Chromosomes (Drosophila melanogaster)


name: SETD8 monomethylates histone H4 (Drosophila melanogaster)


name: PHF8 demethylates histone H4K20me1 (Drosophila melanogaster)


name: Condensation of Prophase Chromosomes (Caenorhabditis elegans)


name: CDK1 phosphorylates condensin II subunit NCAPD3 (Caenorhabditis elegans)


name: PHF8 demethylates histone H4K20me1 (Caenorhabditis elegans)


name: PLK1 hyperphosphorylates Condensin II complex (Caenorhabditis elegans)


name: SETD8 monomethylates histone H4 (Caenorhabditis elegans)


name: PLK1 binds phosphorylated condensin II complex (Caenorhabditis elegans)


name: Condensation of Prophase Chromosomes (Dictyostelium discoideum)


name: PLK1 hyperphosphorylates Condensin II complex (Dictyostelium discoideum)


name: PHF8 demethylates histone H4K20me1 (Dictyostelium discoideum)


name: RB1 binds condensin II (Dictyostelium discoideum)


name: PLK1 binds phosphorylated condensin II complex (Dictyostelium discoideum)


name: Condensin II complex binds H4K20me1-containing nucleosomes (Dictyostelium discoideum)


name: Condensation of Prophase Chromosomes (Schizosaccharomyces pombe)


name: PHF8 demethylates histone H4K20me1 (Schizosaccharomyces pombe)


name: Condensation of Prophase Chromosomes (Saccharomyces cerevisiae)


name: PHF8 demethylates histone H4K20me1 (Saccharomyces cerevisiae)


name: Condensation of Prophase Chromosomes (Plasmodium falciparum)


name: PLK1 hyperphosphorylates Condensin II complex (Plasmodium falciparum)


name: PLK1 binds phosphorylated condensin II complex (Plasmodium falciparum)


name: Condensin II complex binds H4K20me1-containing nucleosomes (Plasmodium falciparum)


name: SETD8 monomethylates histone H4 (Plasmodium falciparum)


name: PHF8 demethylates histone H4K20me1 (Plasmodium falciparum)


name: VRK1/VRK2 phosphorylate BANF1 (Bos taurus)


name: Nuclear Pore Complex (NPC) Disassembly (Bos taurus)


name: NEK6/NEK7 phosphorylates NUP98 (Bos taurus)


name: Nuclear Pore Complex (NPC) Disassembly (Homo sapiens)


name: CDK1 phosphorylates NUP98 (Homo sapiens)


name: NEK6/NEK7 phosphorylates NUP98 (Homo sapiens)


name: Nuclear Pore Complex (NPC) Disassembly (Mus musculus)


name: CDK1 phosphorylates NUP98 (Mus musculus)


name: Nuclear Pore Complex (NPC) Disassembly (Rattus norvegicus)


name: CDK1 phosphorylates NUP98 (Rattus norvegicus)


name: Nuclear Pore Complex (NPC) Disassembly (Canis familiaris)


name: NEK6/NEK7 phosphorylates NUP98 (Canis familiaris)


name: CDK1 phosphorylates NUP98 (Canis familiaris)


name: Nuclear Pore Complex (NPC) Disassembly (Sus scrofa)


name: NEK6/NEK7 phosphorylates NUP98 (Sus scrofa)


name: Nuclear Pore Complex (NPC) Disassembly (Xenopus tropicalis)


name: CDK1 phosphorylates NUP98 (Xenopus tropicalis)


name: Nuclear Pore Complex (NPC) Disassembly (Gallus gallus)


name: NEK6/NEK7 phosphorylates NUP98 (Gallus gallus)


name: CDK1 phosphorylates NUP98 (Gallus gallus)


name: Nuclear Pore Complex (NPC) Disassembly (Drosophila melanogaster)


name: CDK1 phosphorylates NUP98 (Drosophila melanogaster)


name: Depolymerization of the Nuclear Lamina (Bos taurus)


name: CTDNEP1:CNEP1R1 dephosphorylates LPIN (Bos taurus)


name: Depolymerization of lamin filaments after PKC-mediated phosphorylation (Bos taurus)


name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Bos taurus)


name: DAG and Ca+2 bind to PKC and tether it to membrane (Bos taurus)


name: CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Bos taurus)


name: Depolymerization of the Nuclear Lamina (Homo sapiens)


name: CTDNEP1:CNEP1R1 dephosphorylates LPIN (Homo sapiens)


name: CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Homo sapiens)


name: DAG and Ca+2 bind to PKC and tether it to membrane (Homo sapiens)


name: Depolymerization of lamin filaments after PKC-mediated phosphorylation (Homo sapiens)


name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Homo sapiens)


name: Depolymerization of the Nuclear Lamina (Mus musculus)


name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Mus musculus)


name: DAG and Ca+2 bind to PKC and tether it to membrane (Mus musculus)


name: CTDNEP1:CNEP1R1 dephosphorylates LPIN (Mus musculus)


name: Depolymerization of lamin filaments after PKC-mediated phosphorylation (Mus musculus)


name: CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Mus musculus)


name: Depolymerization of the Nuclear Lamina (Rattus norvegicus)


name: Depolymerization of lamin filaments after PKC-mediated phosphorylation (Rattus norvegicus)


name: CDK1 phosphorylates LPIN (Rattus norvegicus)


name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Rattus norvegicus)


name: DAG and Ca+2 bind to PKC and tether it to membrane (Rattus norvegicus)


name: CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Rattus norvegicus)


name: CTDNEP1:CNEP1R1 dephosphorylates LPIN (Rattus norvegicus)


name: Depolymerization of the Nuclear Lamina (Canis familiaris)


name: Depolymerization of lamin filaments after PKC-mediated phosphorylation (Canis familiaris)


name: CTDNEP1:CNEP1R1 dephosphorylates LPIN (Canis familiaris)


name: DAG and Ca+2 bind to PKC and tether it to membrane (Canis familiaris)


name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Canis familiaris)


name: CDK1 phosphorylates LPIN (Canis familiaris)


name: CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Canis familiaris)


name: Depolymerization of the Nuclear Lamina (Sus scrofa)


name: CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Sus scrofa)


name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Sus scrofa)


name: CTDNEP1:CNEP1R1 dephosphorylates LPIN (Sus scrofa)


name: DAG and Ca+2 bind to PKC and tether it to membrane (Sus scrofa)


name: Depolymerization of lamin filaments after PKC-mediated phosphorylation (Sus scrofa)


name: Depolymerization of the Nuclear Lamina (Danio rerio)


name: DAG and Ca+2 bind to PKC and tether it to membrane (Danio rerio)


name: CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Danio rerio)


name: Depolymerization of the Nuclear Lamina (Xenopus tropicalis)


name: Depolymerization of lamin filaments after PKC-mediated phosphorylation (Xenopus tropicalis)


name: DAG and Ca+2 bind to PKC and tether it to membrane (Xenopus tropicalis)


name: CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Xenopus tropicalis)


name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Xenopus tropicalis)


name: CTDNEP1:CNEP1R1 dephosphorylates LPIN (Xenopus tropicalis)


name: CDK1 phosphorylates LPIN (Xenopus tropicalis)


name: Depolymerization of the Nuclear Lamina (Gallus gallus)


name: DAG and Ca+2 bind to PKC and tether it to membrane (Gallus gallus)


name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Gallus gallus)


name: Depolymerization of the Nuclear Lamina (Drosophila melanogaster)


name: CDK1 phosphorylates LPIN (Drosophila melanogaster)


name: CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Drosophila melanogaster)


name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Drosophila melanogaster)


name: CTDNEP1:CNEP1R1 dephosphorylates LPIN (Drosophila melanogaster)


name: DAG and Ca+2 bind to PKC and tether it to membrane (Drosophila melanogaster)


name: Depolymerization of the Nuclear Lamina (Caenorhabditis elegans)


name: CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Caenorhabditis elegans)


name: CTDNEP1:CNEP1R1 dephosphorylates LPIN (Caenorhabditis elegans)


name: CDK1 phosphorylates LPIN (Caenorhabditis elegans)


name: DAG and Ca+2 bind to PKC and tether it to membrane (Caenorhabditis elegans)


name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Caenorhabditis elegans)


name: Depolymerization of the Nuclear Lamina (Dictyostelium discoideum)


name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Dictyostelium discoideum)


name: DAG and Ca+2 bind to PKC and tether it to membrane (Dictyostelium discoideum)


name: Depolymerization of the Nuclear Lamina (Schizosaccharomyces pombe)


name: CTDNEP1:CNEP1R1 dephosphorylates LPIN (Schizosaccharomyces pombe)


name: DAG and Ca+2 bind to PKC and tether it to membrane (Schizosaccharomyces pombe)


name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Schizosaccharomyces pombe)


name: Depolymerization of the Nuclear Lamina (Saccharomyces cerevisiae)


name: DAG and Ca+2 bind to PKC and tether it to membrane (Saccharomyces cerevisiae)


name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Saccharomyces cerevisiae)


name: Depolymerization of the Nuclear Lamina (Plasmodium falciparum)


name: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Plasmodium falciparum)


name: Activation of NIMA Kinases NEK9, NEK6, NEK7 (Bos taurus)


name: NEK9 binds NEK6/NEK7 in the cytosol (Bos taurus)


name: NEK9 phosphorylates NEK6/NEK7 (Bos taurus)


name: CDK1:CCNB phosphorylates NEK9 (Bos taurus)


name: Activation of NIMA Kinases NEK9, NEK6, NEK7 (Homo sapiens)


name: NEK9 phosphorylates NEK6/NEK7 (Homo sapiens)


name: NEK9 binds NEK6/NEK7 in the cytosol (Homo sapiens)


name: CDK1:CCNB phosphorylates NEK9 (Homo sapiens)


name: Activation of NIMA Kinases NEK9, NEK6, NEK7 (Mus musculus)


name: CDK1:CCNB phosphorylates NEK9 (Mus musculus)


name: Activation of NIMA Kinases NEK9, NEK6, NEK7 (Rattus norvegicus)


name: PLK1 phosphorylates NEK9 (Rattus norvegicus)


name: CDK1:CCNB phosphorylates NEK9 (Rattus norvegicus)


name: Activation of NIMA Kinases NEK9, NEK6, NEK7 (Canis familiaris)


name: PLK1 phosphorylates NEK9 (Canis familiaris)


name: NEK9 phosphorylates NEK6/NEK7 (Canis familiaris)


name: CDK1:CCNB phosphorylates NEK9 (Canis familiaris)


name: NEK9 binds NEK6/NEK7 in the cytosol (Canis familiaris)


name: Activation of NIMA Kinases NEK9, NEK6, NEK7 (Sus scrofa)


name: NEK9 phosphorylates NEK6/NEK7 (Sus scrofa)


name: CDK1:CCNB phosphorylates NEK9 (Sus scrofa)


name: NEK9 binds NEK6/NEK7 in the cytosol (Sus scrofa)


name: Activation of NIMA Kinases NEK9, NEK6, NEK7 (Gallus gallus)


name: NEK9 phosphorylates NEK6/NEK7 (Gallus gallus)


name: NEK9 binds NEK6/NEK7 in the cytosol (Gallus gallus)


name: CDK1:CCNB phosphorylates NEK9 (Gallus gallus)


name: PLK1 phosphorylates NEK9 (Gallus gallus)


name: Activation of NIMA Kinases NEK9, NEK6, NEK7 (Caenorhabditis elegans)


name: NEK9 binds NEK6/NEK7 in the cytosol (Caenorhabditis elegans)


name: NEK9 phosphorylates NEK6/NEK7 (Caenorhabditis elegans)


name: PLK1 phosphorylates NEK9 (Caenorhabditis elegans)


name: CDK1:CCNB phosphorylates NEK9 (Caenorhabditis elegans)


name: Nuclear Envelope Breakdown (Homo sapiens)


name: VRK1/VRK2 phosphorylate BANF1 (Homo sapiens)


name: Nuclear Envelope Breakdown (Mus musculus)


name: VRK1/VRK2 phosphorylate BANF1 (Mus musculus)


name: Nuclear Envelope Breakdown (Rattus norvegicus)


name: VRK1/VRK2 phosphorylate BANF1 (Rattus norvegicus)


name: Nuclear Envelope Breakdown (Canis familiaris)


name: VRK1/VRK2 phosphorylate BANF1 (Canis familiaris)


name: VRK1/VRK2 phosphorylate BANF1 (Sus scrofa)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Bos taurus)


name: MAPK3-3 or MAPK1 phosphorylate GORASP2 (Bos taurus)


name: PLK1 phosphorylates GORASP1 (Bos taurus)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Homo sapiens)


name: Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65) (Homo sapiens)


name: GORASP1 phosphorylated by PLK1 and GORASP2 phosphorylated by MAPK3-3/MAPK1 are unable to promote Golgi cisternae stacking (Homo sapiens)


name: Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB (Homo sapiens)


name: GOLGA2 phosphorylated by CDK1 is unable to promote fusion of ER to Golgi transport vesicles with cis-Golgi (Homo sapiens)


name: MAPK3-3 or MAPK1 phosphorylate GORASP2 (Homo sapiens)


name: PLK1 phosphorylates GORASP1 (Homo sapiens)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Mus musculus)


name: PLK1 phosphorylates GORASP1 (Mus musculus)


name: MAPK3-3 or MAPK1 phosphorylate GORASP2 (Mus musculus)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Rattus norvegicus)


name: MAPK3-3 or MAPK1 phosphorylate GORASP2 (Rattus norvegicus)


name: PLK1 phosphorylates GORASP1 (Rattus norvegicus)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Canis familiaris)


name: MAPK3-3 or MAPK1 phosphorylate GORASP2 (Canis familiaris)


name: PLK1 phosphorylates GORASP1 (Canis familiaris)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Sus scrofa)


name: MAPK3-3 or MAPK1 phosphorylate GORASP2 (Sus scrofa)


name: PLK1 phosphorylates GORASP1 (Sus scrofa)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Danio rerio)


name: MAPK3-3 or MAPK1 phosphorylate GORASP2 (Danio rerio)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Xenopus tropicalis)


name: MAPK3-3 or MAPK1 phosphorylate GORASP2 (Xenopus tropicalis)


name: PLK1 phosphorylates GORASP1 (Xenopus tropicalis)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Gallus gallus)


name: MAPK3-3 or MAPK1 phosphorylate GORASP2 (Gallus gallus)


name: PLK1 phosphorylates GORASP1 (Gallus gallus)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Drosophila melanogaster)


name: MAPK3-3 or MAPK1 phosphorylate GORASP2 (Drosophila melanogaster)


name: PLK1 phosphorylates GORASP1 (Drosophila melanogaster)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Caenorhabditis elegans)


name: PLK1 phosphorylates GORASP1 (Caenorhabditis elegans)


name: MAPK3-3 or MAPK1 phosphorylate GORASP2 (Caenorhabditis elegans)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Dictyostelium discoideum)


name: PLK1 phosphorylates GORASP1 (Dictyostelium discoideum)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Schizosaccharomyces pombe)


name: PLK1 phosphorylates GORASP1 (Schizosaccharomyces pombe)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Saccharomyces cerevisiae)


name: PLK1 phosphorylates GORASP1 (Saccharomyces cerevisiae)


name: Golgi Cisternae Pericentriolar Stack Reorganization (Plasmodium falciparum)


name: PLK1 phosphorylates GORASP1 (Plasmodium falciparum)


name: MASTL Facilitates Mitotic Progression (Bos taurus)


name: MASTL (GWL) phosphorylates ARPP19 (Bos taurus)


name: MASTL Facilitates Mitotic Progression (Homo sapiens)


name: MASTL (GWL) phosphorylates ARPP19 (Homo sapiens)


name: p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D (Homo sapiens)


name: MASTL phosphorylates ENSA (Homo sapiens)


name: CDK1 phosphorylates MASTL (Homo sapiens)


name: MASTL Facilitates Mitotic Progression (Mus musculus)


name: MASTL (GWL) phosphorylates ARPP19 (Mus musculus)


name: MASTL Facilitates Mitotic Progression (Rattus norvegicus)


name: MASTL (GWL) phosphorylates ARPP19 (Rattus norvegicus)


name: MASTL Facilitates Mitotic Progression (Canis familiaris)


name: MASTL phosphorylates ENSA (Canis familiaris)


name: MASTL Facilitates Mitotic Progression (Sus scrofa)


name: MASTL (GWL) phosphorylates ARPP19 (Sus scrofa)


name: MASTL Facilitates Mitotic Progression (Danio rerio)


name: MASTL (GWL) phosphorylates ARPP19 (Danio rerio)


name: MASTL Facilitates Mitotic Progression (Gallus gallus)


name: MASTL phosphorylates ENSA (Gallus gallus)


name: MASTL (GWL) phosphorylates ARPP19 (Gallus gallus)


name: MASTL Facilitates Mitotic Progression (Drosophila melanogaster)


name: MASTL phosphorylates ENSA (Drosophila melanogaster)


name: MASTL (GWL) phosphorylates ARPP19 (Drosophila melanogaster)


name: MASTL Facilitates Mitotic Progression (Schizosaccharomyces pombe)


name: MASTL phosphorylates ENSA (Schizosaccharomyces pombe)


name: MASTL (GWL) phosphorylates ARPP19 (Schizosaccharomyces pombe)


name: MASTL Facilitates Mitotic Progression (Saccharomyces cerevisiae)


name: MASTL phosphorylates ENSA (Saccharomyces cerevisiae)


name: MASTL (GWL) phosphorylates ARPP19 (Saccharomyces cerevisiae)


name: Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Bos taurus)


name: Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Bos taurus)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Bos taurus)


name: TP53I3 oxidoreductase generates unstable semiquinones (Bos taurus)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)


name: TP53 binds the BIRC5 gene (Homo sapiens)


name: TP53 family members bind the TP53I3 (PIG3) gene promoter (Homo sapiens)


name: TP53 or TP63 binds the PERP gene (Homo sapiens)


name: TP53 inhibits BIRC5 expression (Homo sapiens)


name: TP53 stimulates RABGGTA expression (Homo sapiens)


name: TP53I3 oxidoreductase generates unstable semiquinones (Homo sapiens)


name: Semiquinone reacts with oxygen (Homo sapiens)


name: TP53 stimulates expression of the TP53I3 (PIG3) gene (Homo sapiens)


name: TP53 stimulates NDRG1 gene expression (Homo sapiens)


name: TP53 or TP63 stimulates PERP gene expression (Homo sapiens)


name: TP53 binds the BCL2L14 gene (Homo sapiens)


name: TP53 binds the RABGGTA gene (Homo sapiens)


name: TP53 binds the NDRG1 gene promoter (Homo sapiens)


name: TP53 stimulates BCL2L14 gene expression (Homo sapiens)


name: TP53 stimulates BCL6 expression (Homo sapiens)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Mus musculus)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Rattus norvegicus)


name: RABGGTA binds RABGGTB (Rattus norvegicus)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Canis familiaris)


name: TP53I3 oxidoreductase generates unstable semiquinones (Canis familiaris)


name: RABGGTA binds RABGGTB (Canis familiaris)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Sus scrofa)


name: TP53I3 oxidoreductase generates unstable semiquinones (Sus scrofa)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Danio rerio)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Xenopus tropicalis)


name: TP53I3 oxidoreductase generates unstable semiquinones (Xenopus tropicalis)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Gallus gallus)


name: TP53I3 oxidoreductase generates unstable semiquinones (Gallus gallus)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Drosophila melanogaster)


name: RABGGTA binds RABGGTB (Drosophila melanogaster)


name: CHM binds RGGT (Drosophila melanogaster)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Caenorhabditis elegans)


name: RABGGTA binds RABGGTB (Caenorhabditis elegans)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Dictyostelium discoideum)


name: RABGGTA binds RABGGTB (Dictyostelium discoideum)


name: TP53I3 oxidoreductase generates unstable semiquinones (Dictyostelium discoideum)


name: TP53I3 dimerizes (Dictyostelium discoideum)


name: CHM binds RGGT (Dictyostelium discoideum)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Schizosaccharomyces pombe)


name: CHM binds RGGT (Schizosaccharomyces pombe)


name: RABGGTA binds RABGGTB (Schizosaccharomyces pombe)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Saccharomyces cerevisiae)


name: CHM binds RGGT (Saccharomyces cerevisiae)


name: RABGGTA binds RABGGTB (Saccharomyces cerevisiae)


name: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Plasmodium falciparum)


name: RABGGTA binds RABGGTB (Plasmodium falciparum)


name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Bos taurus)


name: TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Bos taurus)


name: TRIAP1 binds PRELID1, PRELID3A (Bos taurus)


name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)


name: TP53 family members stimulate BAX transcription (Homo sapiens)


name: TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Homo sapiens)


name: ZNF420 binds TP53AIP1 gene (Homo sapiens)


name: TP53 stimulates STEAP3 expression (Homo sapiens)


name: TP53 family members bind the BAX promoter (Homo sapiens)


name: TP53 and CREBBP bind BNIP3L gene (Homo sapiens)


name: TP53 binds the BID gene promoter (Homo sapiens)


name: TP53 stimulates BNIP3L expression (Homo sapiens)


name: TP53 stimulates TRIAP1 expression (Homo sapiens)


name: TP53 stimulates BID gene expression (Homo sapiens)


name: TP53 binds the TP53INP1 gene (Homo sapiens)


name: ATM phosphorylates ZNF420 (Homo sapiens)


name: TP53 binds the TRIAP1 gene (Homo sapiens)


name: TP53 stimulates expression of TP53INP1 (Homo sapiens)


name: TP53 binds the AIFM2 gene promoter (Homo sapiens)


name: TP53 binds the STEAP3 gene (Homo sapiens)


name: TP53 stimulates AIFM2 gene expression (Homo sapiens)


name: TP53 binds the TP53AIP1 gene (Homo sapiens)


name: TP53 stimulates and ZNF420 inhibits TP53AIP1 expression (Homo sapiens)


name: TRIAP1 binds PRELID1, PRELID3A (Homo sapiens)


name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Mus musculus)


name: ATM phosphorylates ZNF420 (Mus musculus)


name: TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Mus musculus)


name: TRIAP1 binds PRELID1, PRELID3A (Mus musculus)


name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Rattus norvegicus)


name: ATM phosphorylates ZNF420 (Rattus norvegicus)


name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Canis familiaris)


name: TRIAP1 binds PRELID1, PRELID3A (Canis familiaris)


name: TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Canis familiaris)


name: ATM phosphorylates ZNF420 (Canis familiaris)


name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Sus scrofa)


name: TRIAP1 binds PRELID1, PRELID3A (Sus scrofa)


name: TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Sus scrofa)


name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Gallus gallus)


name: TRIAP1 binds PRELID1, PRELID3A (Gallus gallus)


name: ATM phosphorylates ZNF420 (Gallus gallus)


name: TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Gallus gallus)


name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Drosophila melanogaster)


name: TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Drosophila melanogaster)


name: TRIAP1 binds PRELID1, PRELID3A (Drosophila melanogaster)


name: ATM phosphorylates ZNF420 (Drosophila melanogaster)


name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Dictyostelium discoideum)


name: TRIAP1 binds PRELID1, PRELID3A (Dictyostelium discoideum)


name: TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Dictyostelium discoideum)


name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Schizosaccharomyces pombe)


name: TRIAP1 binds PRELID1, PRELID3A (Schizosaccharomyces pombe)


name: TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Schizosaccharomyces pombe)


name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Saccharomyces cerevisiae)


name: TRIAP1 binds PRELID1, PRELID3A (Saccharomyces cerevisiae)


name: TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Saccharomyces cerevisiae)


name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Plasmodium falciparum)


name: TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Plasmodium falciparum)


name: TRIAP1 binds PRELID1, PRELID3A (Plasmodium falciparum)


name: TP53 Regulates Transcription of Caspase Activators and Caspases (Bos taurus)


name: PIDD1 associates with CRADD (Bos taurus)


name: The PIDDosome activates CASP2 (Bos taurus)


name: PIDD1 translocates to the cytosol (Bos taurus)


name: TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)


name: PIDD1 translocates to the cytosol (Homo sapiens)


name: TP53 binds the CASP10 gene (Homo sapiens)


name: PIDD1 associates with CRADD (Homo sapiens)


name: TP53 stimulates CASP10 expression (Homo sapiens)


name: cysteine-type endopeptidase activity involved in apoptotic process

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process.


name: The PIDDosome binds CASP2 (Homo sapiens)


name: TP53 binds the CASP6 gene (Homo sapiens)


name: TP53 stimulates APAF1 gene expression (Homo sapiens)


name: TP53 binds the APAF1 gene promoter (Homo sapiens)


name: TP53 binds the PIDD1 gene (Homo sapiens)


name: TP53 binds the NLRC4 gene (Homo sapiens)


name: TP53 stimulates PIDD1 expression (Homo sapiens)


name: TP53 stimulates CASP6 expression (Homo sapiens)


name: TP53 family members stimulate CASP1 expression (Homo sapiens)


name: TP53 family members bind the CASP1 gene (Homo sapiens)


name: TP53 stimulates NLRC4 expression (Homo sapiens)


name: TP53 Regulates Transcription of Caspase Activators and Caspases (Mus musculus)


name: PIDD1 translocates to the cytosol (Mus musculus)


name: The PIDDosome binds CASP2 (Mus musculus)


name: The PIDDosome activates CASP2 (Mus musculus)


name: PIDD1 associates with CRADD (Mus musculus)


name: TP53 Regulates Transcription of Caspase Activators and Caspases (Rattus norvegicus)


name: PIDD1 translocates to the cytosol (Rattus norvegicus)


name: The PIDDosome binds CASP2 (Rattus norvegicus)


name: ATM phosphorylates PIDD1 (Rattus norvegicus)


name: The PIDDosome activates CASP2 (Rattus norvegicus)


name: PIDD1 associates with CRADD (Rattus norvegicus)


name: TP53 Regulates Transcription of Caspase Activators and Caspases (Canis familiaris)


name: PIDD1 associates with CRADD (Canis familiaris)


name: ATM phosphorylates PIDD1 (Canis familiaris)


name: PIDD1 translocates to the cytosol (Canis familiaris)


name: TP53 Regulates Transcription of Caspase Activators and Caspases (Sus scrofa)


name: PIDD1 translocates to the cytosol (Sus scrofa)


name: TP53 Regulates Transcription of Caspase Activators and Caspases (Drosophila melanogaster)


name: The PIDDosome activates CASP2 (Drosophila melanogaster)


name: The PIDDosome binds CASP2 (Drosophila melanogaster)


name: PIDD1 translocates to the cytosol (Drosophila melanogaster)


name: PIDD1 associates with CRADD (Drosophila melanogaster)


name: ATM phosphorylates PIDD1 (Drosophila melanogaster)


name: TP53 Regulates Transcription of Death Receptors and Ligands (Bos taurus)


name: TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)


name: TP53 binds the IGFBP3 gene (Homo sapiens)


name: TP53 stimulates IGFBP3 expression (Homo sapiens)


name: TP53 family members stimulate FAS gene expression (Homo sapiens)


name: TP53 stimulates transcription of TNFRSF10A, TNFRSF10B,TNFRSF10C and TNFRSF10D genes (Homo sapiens)


name: TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes (Homo sapiens)


name: TP53 family members bind the FAS gene (Homo sapiens)


name: TP53 Regulates Transcription of Death Receptors and Ligands (Mus musculus)


name: TP53 Regulates Transcription of Death Receptors and Ligands (Rattus norvegicus)


name: IGFBP3 binds TMEM219 (Rattus norvegicus)


name: TP53 Regulates Transcription of Death Receptors and Ligands (Sus scrofa)


name: TP53 Regulates Transcription of Death Receptors and Ligands (Danio rerio)


name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)


name: TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)


name: Regulation of TLR by endogenous ligand (Bos taurus)


name: S100A8:S100A9 binds TLR4:LY96 (Bos taurus)


name: G or G analog binds C-ter TLR7 dimer (Bos taurus)


name: SFTPA/SFTPD binds TLR4:LY96 (Bos taurus)


name: oxLDL:CD36 binds TLR4:TLR6 (Bos taurus)


name: Cleaved fibrinogen products bind TLR4:LY96 (Bos taurus)


pyroptotic inflammatory response

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A gasdermin-dependent inflammatory response that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. Gasdermins are activated by caspase-1 or caspase-4/11, or by certain granzymes. In some, but not all cells, it can lead to pyroptotic programmed cell death.


name: Disulfiram covalently modifies Cys191 in GSDMD (Bos taurus)


name: GSDMD (1-275) binds cardiolipin (Bos taurus)


name: GSDME (1-270) binds cardiolipin (Bos taurus)


name: GSDMD forms ring‐shaped oligomers  (Bos taurus)


name: Interleukin-1 family are secreted (Bos taurus)


name: Dimethyl fumarate modifies Cys191 in GSDMD (Bos taurus)


name: GSDMD (1-275) binds bacterial cardiolipin (Bos taurus)


name: GSDMD oligomerizes into arc-, slit-shaped structures (Bos taurus)


name: IL37(?-218) binds p-S423,S425-SMAD3 (Bos taurus)


name: IL37, IL37(?-218) translocates from cytosol to extracellular region (Bos taurus)


name: IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Bos taurus)


name: IL37(?-218) translocates from the cytosol to the nucleus (Bos taurus)


name: IL37, IL37(?-218) binds IL18BP (Bos taurus)


name: IL37, IL37(?-218) translocates from cytosol to extracellular region (Homo sapiens)


name: IL37(?-218) binds p-S423,S425-SMAD3 (Homo sapiens)


name: PTPNs gene transcription and translation (Homo sapiens)


name: IL37(?-218) translocates from the cytosol to the nucleus (Homo sapiens)


name: IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Homo sapiens)


name: IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Homo sapiens)


name: IL37, IL37(?-218) binds IL18BP (Homo sapiens)


name: Interleukin-37 signaling (Rattus norvegicus)


name: STAT3 phosphorylation (Rattus norvegicus)


name: TBK1 phosphorylation (Rattus norvegicus)


name: Interleukin-37 signaling (Canis familiaris)


name: IL37:IL18R1 binds SIGIRR (Canis familiaris)


name: IL37, IL37(?-218) translocates from cytosol to extracellular region (Canis familiaris)


name: STAT3 phosphorylation (Canis familiaris)


name: IL37(?-218) binds p-S423,S425-SMAD3 (Canis familiaris)


name: IL37(?-218) translocates from the cytosol to the nucleus (Canis familiaris)


name: IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Canis familiaris)


name: IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Canis familiaris)


name: IL37(?-218) binds SMAD3 (Canis familiaris)


name: IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Canis familiaris)


name: IL37, IL37(?-218) translocates from cytosol to extracellular region (Danio rerio)


name: IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Danio rerio)


name: IL37(?-218) binds p-S423,S425-SMAD3 (Danio rerio)


name: IL37(?-218) translocates from the cytosol to the nucleus (Danio rerio)


name: Interleukin-37 signaling (Xenopus tropicalis)


name: STAT3 phosphorylation (Xenopus tropicalis)


name: IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Xenopus tropicalis)


name: IL37:IL18R1 binds SIGIRR (Xenopus tropicalis)


name: IL37(?-218) translocates from the cytosol to the nucleus (Xenopus tropicalis)


name: IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Xenopus tropicalis)


name: TBK1 phosphorylation (Xenopus tropicalis)


name: IL37, IL37(?-218) translocates from cytosol to extracellular region (Xenopus tropicalis)


name: Interleukin-37 signaling (Gallus gallus)


name: Interleukin-37 signaling (Drosophila melanogaster)


name: TBK1 phosphorylation (Drosophila melanogaster)


name: STAT3 phosphorylation (Drosophila melanogaster)


name: Interleukin-37 signaling (Caenorhabditis elegans)


name: STAT3 phosphorylation (Caenorhabditis elegans)


name: Interleukin-37 signaling (Dictyostelium discoideum)


name: STAT3 phosphorylation (Dictyostelium discoideum)


name: Formation of caspase-1 p10/p20 dimer (Bos taurus)


name: Interleukin-1 family precursors are cleaved by caspase-1 (Bos taurus)


name: Caspase-1 active tetramer formation (Bos taurus)


name: Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)


name: Caspase-1 active tetramer formation (Homo sapiens)


name: Formation of caspase-1 p10/p20 dimer (Homo sapiens)


name: Interleukin-1 family are secreted (Homo sapiens)


name: CTSG cleaves CASP1(1-404) (Homo sapiens)


name: CASP4, CASP5 cleave GSDMD (Homo sapiens)


name: GSDMD expression mediated by IRF2, IRF1 (Homo sapiens)


name: IRF2 or IRF1 binds the GSDMD gene promoter (Homo sapiens)


name: GSDMD (1-275) binds cardiolipin (Homo sapiens)


name: GSDME (1-270) binds cardiolipin (Homo sapiens)


name: TP53 or TP63 binds the GSDME gene (Homo sapiens)


name: GSDMD (1-275) binds bacterial cardiolipin (Homo sapiens)


name: GSDMD oligomerizes into arc-, slit-shaped structures (Homo sapiens)


name: GSDMD forms ring‐shaped oligomers  (Homo sapiens)


name: GSDME expression mediated by TP53, TP63 (Homo sapiens)


name: Dimethyl fumarate modifies Cys191 in GSDMD (Homo sapiens)


name: Disulfiram covalently modifies Cys191 in GSDMD (Homo sapiens)


name: IL33:IL1RL1 binds IL1RAP-1 (Homo sapiens)


name: IL33:IL1RL1 binds IL1RAP-1 (Mus musculus)


name: Interleukin-33 signaling (Rattus norvegicus)


name: IL33:IL1RL1 binds IL1RAP-1 (Rattus norvegicus)


name: IL36RN, IL1F10 bind IL1RL2 (Homo sapiens)


name: IL36:IL1RL2 binds IL1RAP-1 (Homo sapiens)


name: IL36RN, IL1F10 bind IL1RL2 (Mus musculus)


name: IL36:IL1RL2 binds IL1RAP-1 (Mus musculus)


name: Interleukin-36 pathway (Rattus norvegicus)


name: IL36RN, IL1F10 bind IL1RL2 (Rattus norvegicus)


name: IL36:IL1RL2 binds IL1RAP-1 (Rattus norvegicus)


name: Interleukin-36 pathway (Canis familiaris)


name: IL36RN, IL1F10 bind IL1RL2 (Canis familiaris)


name: IL36:IL1RL2 binds IL1RAP-1 (Canis familiaris)


name: Interleukin-36 pathway (Xenopus tropicalis)


name: IL36:IL1RL2 binds IL1RAP-1 (Xenopus tropicalis)


name: IL36RN, IL1F10 bind IL1RL2 (Xenopus tropicalis)


name: hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Homo sapiens)


name: Hyperphosphorylated IRAK1 associates with TRAF6 (Homo sapiens)


name: TAK1 is activated within the TAK1 complex (Homo sapiens)


name: hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Homo sapiens)


name: Polyubiquitinated TRAF6 binds the TAK1 complex (Homo sapiens)


name: The Interleukin 1 receptor complex binds Tollip (Homo sapiens)


name: IL1R1:IL1:IL1RAP binds MYD88 homodimer (Homo sapiens)


name: hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Homo sapiens)


name: IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Homo sapiens)


name: TRAF6 is K63 poly-ubiquitinated (Homo sapiens)


name: Pellino ubiquitinates IRAK1 (Homo sapiens)


name: IRAK4 phosphorylates IRAK1 (Homo sapiens)


name: IRAK1 binds to MYD88 within the IL1R complex (Homo sapiens)


name: Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Homo sapiens)


name: SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Homo sapiens)


name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Homo sapiens)


name: hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Homo sapiens)


name: TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)


name: K63polyUb-IRAK1 dissociates (Homo sapiens)


name: IRAK4-activated IRAK1 autophosphorylates (Homo sapiens)


name: IRAK4 is activated by autophosphorylation (Homo sapiens)


name: NEMO binds polyubiquitinated IRAK1 (Homo sapiens)


name: IL1R1 binds IL1R1 inhibitors (Homo sapiens)

definition: Inhibition


name: Interleukin-1 receptor type 2 binds Interleukin 1 (Homo sapiens)


name: UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Homo sapiens)


name: IL1 receptor antagonist protein binds Interleukin 1 receptors (Homo sapiens)


name: IRAK1 induces oligomerisation of TRAF6 (Homo sapiens)


name: IKBA is phosphorylated by Phospho IKKB kinase (Homo sapiens)


name: Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Homo sapiens)


name: IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Homo sapiens)


name: Hyperphosphorylated IRAK1 associates with TRAF6 (Mus musculus)


name: The Interleukin 1 receptor complex binds Tollip (Mus musculus)


name: IL1 receptor antagonist protein binds Interleukin 1 receptors (Mus musculus)


name: hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Mus musculus)


name: IRAK4-activated IRAK1 autophosphorylates (Mus musculus)


name: Interleukin-1 receptor type 2 binds Interleukin 1 (Mus musculus)


name: K63polyUb-IRAK1 dissociates (Mus musculus)


name: hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Mus musculus)


name: IL1R1 binds IL1R1 inhibitors (Mus musculus)


name: Pellino ubiquitinates IRAK1 (Mus musculus)


name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Mus musculus)


name: NEMO binds polyubiquitinated IRAK1 (Mus musculus)


name: IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Mus musculus)


name: IL1R1:IL1:IL1RAP binds MYD88 homodimer (Mus musculus)


name: TRAF6 is K63 poly-ubiquitinated (Mus musculus)


name: IRAK1 induces oligomerisation of TRAF6 (Mus musculus)


name: Polyubiquitinated TRAF6 binds the TAK1 complex (Mus musculus)


name: IRAK4 is activated by autophosphorylation (Mus musculus)


name: IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Mus musculus)


name: hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Mus musculus)


name: IKBA is phosphorylated by Phospho IKKB kinase (Mus musculus)


name: SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Mus musculus)


name: IRAK4 phosphorylates IRAK1 (Mus musculus)


name: Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Mus musculus)


name: TAK1 is activated within the TAK1 complex (Mus musculus)


name: IRAK1 binds to MYD88 within the IL1R complex (Mus musculus)


name: TRAF6 binding leads to IRAK1:TRAF6 release (Mus musculus)


name: UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Mus musculus)


name: Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Mus musculus)


name: hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Mus musculus)


name: Interleukin-1 signaling (Rattus norvegicus)


name: IRAK4 phosphorylates IRAK1 (Rattus norvegicus)


name: TRAF6 binding leads to IRAK1:TRAF6 release (Rattus norvegicus)


name: hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Rattus norvegicus)


name: TRAF6 is K63 poly-ubiquitinated (Rattus norvegicus)


name: IRAK4-activated IRAK1 autophosphorylates (Rattus norvegicus)


name: Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Rattus norvegicus)


name: NEMO binds polyubiquitinated IRAK1 (Rattus norvegicus)


name: The Interleukin 1 receptor complex binds Tollip (Rattus norvegicus)


name: IKBA is phosphorylated by Phospho IKKB kinase (Rattus norvegicus)


name: Hyperphosphorylated IRAK1 associates with TRAF6 (Rattus norvegicus)


name: Pellino ubiquitinates IRAK1 (Rattus norvegicus)


name: Interleukin-1 receptor type 2 binds Interleukin 1 (Rattus norvegicus)


name: p62:MEKK3 binds to TRAF6 (Rattus norvegicus)


name: Polyubiquitinated TRAF6 binds the TAK1 complex (Rattus norvegicus)


name: IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Rattus norvegicus)


name: IRAK4 is activated by autophosphorylation (Rattus norvegicus)


name: IL1R1 binds IL1R1 inhibitors (Rattus norvegicus)


name: Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Rattus norvegicus)


name: IRAK1 induces oligomerisation of TRAF6 (Rattus norvegicus)


name: IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Rattus norvegicus)


name: IL1R1:IL1:IL1RAP binds MYD88 homodimer (Rattus norvegicus)


name: hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Rattus norvegicus)


name: IL1 receptor antagonist protein binds Interleukin 1 receptors (Rattus norvegicus)


name: IRAK1 binds to MYD88 within the IL1R complex (Rattus norvegicus)


name: TAK1 is activated within the TAK1 complex (Rattus norvegicus)


name: Interleukin-1 signaling (Canis familiaris)


name: hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Canis familiaris)


name: IL1R1:IL1:IL1RAP binds MYD88 homodimer (Canis familiaris)


name: Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Canis familiaris)


name: Polyubiquitinated TRAF6 binds the TAK1 complex (Canis familiaris)


name: IRAK4 is activated by autophosphorylation (Canis familiaris)


name: IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Canis familiaris)


name: UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Canis familiaris)


name: SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Canis familiaris)


name: TAK1 is activated within the TAK1 complex (Canis familiaris)


name: NEMO binds polyubiquitinated IRAK1 (Canis familiaris)


name: TRAF6 is K63 poly-ubiquitinated (Canis familiaris)


name: hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Canis familiaris)


name: IRAK1 induces oligomerisation of TRAF6 (Canis familiaris)


name: Pellino ubiquitinates IRAK1 (Canis familiaris)


name: IKBA is phosphorylated by Phospho IKKB kinase (Canis familiaris)


name: IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Canis familiaris)


name: K63polyUb-IRAK1 dissociates (Canis familiaris)


name: IRAK1 binds to MYD88 within the IL1R complex (Canis familiaris)


name: hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Canis familiaris)


name: TRAF6 binding leads to IRAK1:TRAF6 release (Canis familiaris)


name: p62:MEKK3 binds to TRAF6 (Canis familiaris)


name: IRAK4 phosphorylates IRAK1 (Canis familiaris)


name: Hyperphosphorylated IRAK1 associates with TRAF6 (Canis familiaris)


name: IRAK4-activated IRAK1 autophosphorylates (Canis familiaris)


name: Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Canis familiaris)


name: The Interleukin 1 receptor complex binds Tollip (Canis familiaris)


name: Interleukin-1 receptor type 2 binds Interleukin 1 (Canis familiaris)


name: IL1 receptor antagonist protein binds Interleukin 1 receptors (Canis familiaris)


name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Canis familiaris)


name: hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Canis familiaris)


name: IL1R1 binds IL1R1 inhibitors (Canis familiaris)


name: IRAK1 binds to MYD88 within the IL1R complex (Bos taurus)


name: hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Bos taurus)


name: TRAF6 is K63 poly-ubiquitinated (Bos taurus)


name: Pellino ubiquitinates IRAK1 (Bos taurus)


name: TRAF6 binding leads to IRAK1:TRAF6 release (Bos taurus)


name: NEMO binds polyubiquitinated IRAK1 (Bos taurus)


name: Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Bos taurus)


name: IRAK1 induces oligomerisation of TRAF6 (Bos taurus)


name: IRAK4-activated IRAK1 autophosphorylates (Bos taurus)


name: IL1R1:IL1:IL1RAP binds MYD88 homodimer (Bos taurus)


name: TAK1 is activated within the TAK1 complex (Bos taurus)


name: The Interleukin 1 receptor complex binds Tollip (Bos taurus)


name: Hyperphosphorylated IRAK1 associates with TRAF6 (Bos taurus)


name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Bos taurus)


name: IL1 receptor antagonist protein binds Interleukin 1 receptors (Bos taurus)


name: Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Bos taurus)


name: Interleukin-1 receptor type 2 binds Interleukin 1 (Bos taurus)


name: SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Bos taurus)


name: IKBA is phosphorylated by Phospho IKKB kinase (Bos taurus)


name: hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Bos taurus)


name: Polyubiquitinated TRAF6 binds the TAK1 complex (Bos taurus)


name: IRAK4 is activated by autophosphorylation (Bos taurus)


name: IL1R1 binds IL1R1 inhibitors (Bos taurus)


name: IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Bos taurus)


name: IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Bos taurus)


name: Polyubiquitinated TRAF6 binds the TAK1 complex (Sus scrofa)


name: IRAK4 is activated by autophosphorylation (Sus scrofa)


name: IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Sus scrofa)


name: hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Sus scrofa)


name: hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Sus scrofa)


name: UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Sus scrofa)


name: IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Sus scrofa)


name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Sus scrofa)


name: TRAF6 is K63 poly-ubiquitinated (Sus scrofa)


name: IRAK1 binds to MYD88 within the IL1R complex (Sus scrofa)


name: TRAF6 binding leads to IRAK1:TRAF6 release (Sus scrofa)


name: Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Sus scrofa)


name: Pellino ubiquitinates IRAK1 (Sus scrofa)


name: IKBA is phosphorylated by Phospho IKKB kinase (Sus scrofa)


name: NEMO binds polyubiquitinated IRAK1 (Sus scrofa)


name: SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Sus scrofa)


name: hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Sus scrofa)


name: hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Sus scrofa)


name: IRAK4-activated IRAK1 autophosphorylates (Sus scrofa)


name: K63polyUb-IRAK1 dissociates (Sus scrofa)


name: IL1R1 binds IL1R1 inhibitors (Sus scrofa)


name: Hyperphosphorylated IRAK1 associates with TRAF6 (Sus scrofa)


name: The Interleukin 1 receptor complex binds Tollip (Sus scrofa)


name: IRAK1 induces oligomerisation of TRAF6 (Sus scrofa)


name: Interleukin-1 receptor type 2 binds Interleukin 1 (Sus scrofa)


name: TAK1 is activated within the TAK1 complex (Sus scrofa)


name: Pellino ubiquitinates IRAK1 (Danio rerio)


name: TRAF6 is K63 poly-ubiquitinated (Danio rerio)


name: Interleukin-1 signaling (Xenopus tropicalis)


name: IL1 receptor antagonist protein binds Interleukin 1 receptors (Xenopus tropicalis)


name: IL1R1 binds IL1R1 inhibitors (Xenopus tropicalis)


name: Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Xenopus tropicalis)


name: Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Xenopus tropicalis)


name: The Interleukin 1 receptor complex binds Tollip (Xenopus tropicalis)


name: IRAK4 is activated by autophosphorylation (Xenopus tropicalis)


name: IL1R1:IL1:IL1RAP binds MYD88 homodimer (Xenopus tropicalis)


name: Interleukin-1 receptor type 2 binds Interleukin 1 (Xenopus tropicalis)


name: IL1R1:IL1:IL1RAP binds MYD88 homodimer (Gallus gallus)


name: Interleukin-1 receptor type 2 binds Interleukin 1 (Gallus gallus)


name: IL1R1 binds IL1R1 inhibitors (Gallus gallus)


name: p62:MEKK3 binds to TRAF6 (Gallus gallus)


name: IRAK4 is activated by autophosphorylation (Gallus gallus)


name: IKBA is phosphorylated by Phospho IKKB kinase (Gallus gallus)


name: SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Gallus gallus)


name: Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Gallus gallus)


name: Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Gallus gallus)


name: The Interleukin 1 receptor complex binds Tollip (Gallus gallus)


name: IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Gallus gallus)


name: Interleukin-1 signaling (Drosophila melanogaster)


name: hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Drosophila melanogaster)


name: NEMO binds polyubiquitinated IRAK1 (Drosophila melanogaster)


name: hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Drosophila melanogaster)


name: IRAK1 induces oligomerisation of TRAF6 (Drosophila melanogaster)


name: Pellino ubiquitinates IRAK1 (Drosophila melanogaster)


name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Drosophila melanogaster)


name: hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Drosophila melanogaster)


name: hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Drosophila melanogaster)


name: SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Drosophila melanogaster)


name: UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Drosophila melanogaster)


name: TRAF6 is K63 poly-ubiquitinated (Drosophila melanogaster)


name: Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Drosophila melanogaster)


name: IKBA is phosphorylated by Phospho IKKB kinase (Drosophila melanogaster)


name: K63polyUb-IRAK1 dissociates (Drosophila melanogaster)


name: Interleukin-1 signaling (Caenorhabditis elegans)


name: hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Caenorhabditis elegans)


name: hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Caenorhabditis elegans)


name: hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Caenorhabditis elegans)


name: K63polyUb-IRAK1 dissociates (Caenorhabditis elegans)


name: TRAF6 is K63 poly-ubiquitinated (Caenorhabditis elegans)


name: Pellino ubiquitinates IRAK1 (Caenorhabditis elegans)


name: Interleukin-1 signaling (Dictyostelium discoideum)


name: TRAF6 is K63 poly-ubiquitinated (Dictyostelium discoideum)


name: Pellino ubiquitinates IRAK1 (Dictyostelium discoideum)


name: Interleukin-1 signaling (Schizosaccharomyces pombe)


name: TRAF6 is K63 poly-ubiquitinated (Schizosaccharomyces pombe)


name: Pellino ubiquitinates IRAK1 (Schizosaccharomyces pombe)


name: Interleukin-1 signaling (Saccharomyces cerevisiae)


name: Pellino ubiquitinates IRAK1 (Saccharomyces cerevisiae)


name: TRAF6 is K63 poly-ubiquitinated (Saccharomyces cerevisiae)


name: IL18:IL18R1 binds IL18RAP (Homo sapiens)


name: Expression of IL18, ALOX5 (Homo sapiens)


name: IL18:IL18R1 binds IL18RAP (Mus musculus)


name: IL1F10(?-152) binds IL1RAPL1 (Mus musculus)


name: IL1F10(?-152) binds IL1RAPL1 (Homo sapiens)


name: Interleukin-38 signaling (Rattus norvegicus)


name: IL1F10(?-152) binds IL1RAPL1 (Rattus norvegicus)


name: MAPK8 phosphorylation (Rattus norvegicus)


name: IL1F10 binds IL1RAPL1 (Rattus norvegicus)


name: Interleukin-38 signaling (Canis familiaris)


name: MAPK8 phosphorylation (Canis familiaris)


name: IL1F10(?-152) binds IL1RAPL1 (Canis familiaris)


name: IL1F10 binds IL1RAPL1 (Canis familiaris)


name: IL1F10(?-152) binds IL1RAPL1 (Danio rerio)


name: Interleukin-38 signaling (Xenopus tropicalis)


name: IL1F10 binds IL1RL2 (Xenopus tropicalis)


name: IL1F10 binds IL1RAPL1 (Xenopus tropicalis)


name: IL1F10(?-152) binds IL1RAPL1 (Xenopus tropicalis)


name: Interleukin-38 signaling (Gallus gallus)


name: Interleukin-38 signaling (Drosophila melanogaster)


name: MAPK8 phosphorylation (Drosophila melanogaster)


name: Interleukin-38 signaling (Caenorhabditis elegans)


name: MAPK8 phosphorylation (Caenorhabditis elegans)


name: Interleukin-38 signaling (Dictyostelium discoideum)


name: MAPK8 phosphorylation (Dictyostelium discoideum)


name: Interleukin-38 signaling (Schizosaccharomyces pombe)


name: MAPK8 phosphorylation (Schizosaccharomyces pombe)


name: Interleukin-38 signaling (Saccharomyces cerevisiae)


name: MAPK8 phosphorylation (Saccharomyces cerevisiae)


name: CTSG cleaves CASP1(1-404) (Mus musculus)


name: Interleukin-1 family precursors are cleaved by caspase-1 (Mus musculus)


name: Formation of caspase-1 p10/p20 dimer (Mus musculus)


name: Interleukin-1 family are secreted (Mus musculus)


name: Caspase-1 active tetramer formation (Mus musculus)


name: CASP4, CASP5 cleave GSDMD (Mus musculus)


name: GSDMD oligomerizes into arc-, slit-shaped structures (Mus musculus)


name: GSDMD (1-275) binds bacterial cardiolipin (Mus musculus)


name: GSDME (1-270) binds cardiolipin (Mus musculus)


name: GSDMD (1-275) binds cardiolipin (Mus musculus)


name: Dimethyl fumarate modifies Cys191 in GSDMD (Mus musculus)


name: GSDMD forms ring‐shaped oligomers  (Mus musculus)


name: Disulfiram covalently modifies Cys191 in GSDMD (Mus musculus)


name: Regulation of TLR by endogenous ligand (Mus musculus)


name: oxLDL:CD36 binds TLR4:TLR6 (Mus musculus)


name: Cleaved fibrinogen products bind TLR4:LY96 (Mus musculus)


name: S100A8:S100A9 binds TLR4:LY96 (Mus musculus)


name: SFTPA/SFTPD binds TLR4:LY96 (Mus musculus)


name: G or G analog binds C-ter TLR7 dimer (Mus musculus)


name: SFTPA/SFTPD binds TLR2:TLR1 (Mus musculus)


name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)


name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Mus musculus)


name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Mus musculus)


name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Mus musculus)


name: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Mus musculus)


name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Mus musculus)


name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)


name: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)


name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)


name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Homo sapiens)


name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Homo sapiens)


name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)


name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Rattus norvegicus)


name: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Rattus norvegicus)


name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Rattus norvegicus)


name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)


name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Canis familiaris)


name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Canis familiaris)


name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Canis familiaris)


name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Canis familiaris)


name: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Canis familiaris)


name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)


name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Bos taurus)


name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)


name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Bos taurus)


name: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Bos taurus)


name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Sus scrofa)


name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Sus scrofa)


name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Sus scrofa)


name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Sus scrofa)


name: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Sus scrofa)


name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Xenopus tropicalis)


name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Xenopus tropicalis)


name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)


name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Gallus gallus)


name: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Gallus gallus)


name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Gallus gallus)


name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)


name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Drosophila melanogaster)


name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Drosophila melanogaster)


name: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Drosophila melanogaster)


name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Mus musculus)


name: Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Mus musculus)


name: IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Mus musculus)


name: Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Mus musculus)


name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Mus musculus)


name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Homo sapiens)


name: IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Homo sapiens)


name: Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Homo sapiens)


name: Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Homo sapiens)


name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Homo sapiens)


name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)


name: IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Rattus norvegicus)


name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Rattus norvegicus)


name: Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Rattus norvegicus)


name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Canis familiaris)


name: Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Canis familiaris)


name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Canis familiaris)


name: IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Canis familiaris)


name: Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Canis familiaris)


name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Bos taurus)


name: Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Bos taurus)


name: IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Bos taurus)


name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Bos taurus)


name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Sus scrofa)


name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Sus scrofa)


name: Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Sus scrofa)


name: IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Sus scrofa)


name: Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Sus scrofa)


name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Drosophila melanogaster)


name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Drosophila melanogaster)


name: IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Drosophila melanogaster)


name: Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Drosophila melanogaster)


name: Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Drosophila melanogaster)


name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)


name: Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)


name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)


name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)


name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)


name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)


name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)


name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)


name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Mus musculus)


name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)


name: Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)


name: TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)


name: TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)


name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Rattus norvegicus)


name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Bos taurus)


name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Sus scrofa)


name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Xenopus tropicalis)


name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Gallus gallus)


name: MyD88 dependent cascade initiated on endosome (Homo sapiens)


name: Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)


name: First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)


name: MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)


name: IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Homo sapiens)


name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)


name: MyD88 interacts with the activated TLR receptor 7, 8 or 9  (Homo sapiens)


name: TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9   (Homo sapiens)


name: IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex  (Homo sapiens)


name: Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)


name: IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)


name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)


name: TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)


name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)


name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)


name: Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)


name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)


name: TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)


name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)


name: TIRAP is phosphorylated by BTK (Homo sapiens)


name: Multiple IRAK1 autophosphorylation steps (Homo sapiens)


name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)


name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)


name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)


name: Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)


name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)


name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)


name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)


name: MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)


name: Regulation of TLR by endogenous ligand (Homo sapiens)


name: SFTPA/SFTPD binds TLR2:TLR1 (Homo sapiens)


name: Cleaved fibrinogen products bind TLR4:LY96 (Homo sapiens)


name: G or G analog binds C-ter TLR7 dimer (Homo sapiens)


name: SFTPA/SFTPD binds TLR4:LY96 (Homo sapiens)


name: oxLDL:CD36 binds TLR4:TLR6 (Homo sapiens)


name: S100A8:S100A9 binds TLR4:LY96 (Homo sapiens)


name: Regulation of TLR by endogenous ligand (Rattus norvegicus)


name: oxLDL:CD36 binds TLR4:TLR6 (Rattus norvegicus)


name: SFTPA/SFTPD binds TLR4:LY96 (Rattus norvegicus)


name: HMGB1 release from cells (Rattus norvegicus)


name: S100A8:S100A9 binds TLR4:LY96 (Rattus norvegicus)


name: S100A1 binds TLR4:LY96 (Rattus norvegicus)


name: G or G analog binds C-ter TLR7 dimer (Rattus norvegicus)


name: HMGB1 binds TLR4:LY96 (Rattus norvegicus)


name: Cleaved fibrinogen products bind TLR4:LY96 (Rattus norvegicus)


name: SFTPA/SFTPD binds TLR2:TLR1 (Rattus norvegicus)


name: GSDMD (1-275) binds cardiolipin (Rattus norvegicus)


name: GSDME (1-270) binds PIPs (Rattus norvegicus)


name: Dimethyl fumarate modifies Cys191 in GSDMD (Rattus norvegicus)


name: GSDME (1-270) binds cardiolipin (Rattus norvegicus)


name: Disulfiram covalently modifies Cys191 in GSDMD (Rattus norvegicus)


name: GSDMD forms ring‐shaped oligomers  (Rattus norvegicus)


name: GSDMD (1-275) binds PIPs (Rattus norvegicus)


name: GSDMD oligomerizes into arc-, slit-shaped structures (Rattus norvegicus)


name: Interleukin-1 family are secreted (Rattus norvegicus)


name: GSDMD (1-275) binds bacterial cardiolipin (Rattus norvegicus)


name: Interleukin-1 processing (Rattus norvegicus)


name: Formation of caspase-1 p10/p20 dimer (Rattus norvegicus)


name: Caspase-1 active tetramer formation (Rattus norvegicus)


name: Interleukin-1 family precursors are cleaved by caspase-1 (Rattus norvegicus)


name: CTSG cleaves CASP1(1-404) (Rattus norvegicus)


name: Interleukin-18 signaling (Rattus norvegicus)


name: IL18:IL18R1 binds IL18RAP (Rattus norvegicus)


name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)


name: TIRAP binds PIP2-rich regions in the plasma membrane (Rattus norvegicus)


name: Regulation of TLR by endogenous ligand (Canis familiaris)


name: Cleaved fibrinogen products bind TLR4:LY96 (Canis familiaris)


name: SFTPA/SFTPD binds TLR4:LY96 (Canis familiaris)


name: S100A1 binds TLR4:LY96 (Canis familiaris)


name: S100A8:S100A9 binds TLR4:LY96 (Canis familiaris)


name: HMGB1 binds TLR4:LY96 (Canis familiaris)


name: SFTPA/SFTPD binds TLR2:TLR1 (Canis familiaris)


name: HMGB1 release from cells (Canis familiaris)


name: G or G analog binds C-ter TLR7 dimer (Canis familiaris)


name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)


name: TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)


name: GSDME (1-270) binds cardiolipin (Canis familiaris)


name: GSDMD forms ring‐shaped oligomers  (Canis familiaris)


name: Disulfiram covalently modifies Cys191 in GSDMD (Canis familiaris)


name: Interleukin-1 family are secreted (Canis familiaris)


name: GSDMD (1-275) binds PIPs (Canis familiaris)


name: Dimethyl fumarate modifies Cys191 in GSDMD (Canis familiaris)


name: GSDMD (1-275) binds bacterial cardiolipin (Canis familiaris)


name: GSDMD oligomerizes into arc-, slit-shaped structures (Canis familiaris)


name: GSDMD (1-275) binds cardiolipin (Canis familiaris)


name: GSDME (1-270) binds PIPs (Canis familiaris)


name: Interleukin-1 processing (Canis familiaris)


name: Formation of caspase-1 p10/p20 dimer (Canis familiaris)


name: Caspase-1 active tetramer formation (Canis familiaris)


name: CTSG cleaves CASP1(1-404) (Canis familiaris)


name: Interleukin-1 family precursors are cleaved by caspase-1 (Canis familiaris)


name: Interleukin-18 signaling (Canis familiaris)


name: IL18:IL18R1 binds IL18RAP (Canis familiaris)


name: Regulation of TLR by endogenous ligand (Sus scrofa)


name: S100A8:S100A9 binds TLR4:LY96 (Sus scrofa)


name: SFTPA/SFTPD binds TLR2:TLR1 (Sus scrofa)


name: G or G analog binds C-ter TLR7 dimer (Sus scrofa)


name: SFTPA/SFTPD binds TLR4:LY96 (Sus scrofa)


name: Cleaved fibrinogen products bind TLR4:LY96 (Sus scrofa)


name: oxLDL:CD36 binds TLR4:TLR6 (Sus scrofa)


name: GSDMD forms ring‐shaped oligomers  (Sus scrofa)


name: Dimethyl fumarate modifies Cys191 in GSDMD (Sus scrofa)


name: Interleukin-1 family are secreted (Sus scrofa)


name: GSDMD (1-275) binds bacterial cardiolipin (Sus scrofa)


name: GSDMD (1-275) binds cardiolipin (Sus scrofa)


name: GSDMD oligomerizes into arc-, slit-shaped structures (Sus scrofa)


name: GSDME (1-270) binds cardiolipin (Sus scrofa)


name: Disulfiram covalently modifies Cys191 in GSDMD (Sus scrofa)


name: Caspase-1 active tetramer formation (Sus scrofa)


name: Formation of caspase-1 p10/p20 dimer (Sus scrofa)


name: Interleukin-1 family precursors are cleaved by caspase-1 (Sus scrofa)


name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)


name: TIRAP binds PIP2-rich regions in the plasma membrane (Sus scrofa)


name: Regulation of TLR by endogenous ligand (Danio rerio)


name: GSDME (1-270) binds cardiolipin (Danio rerio)


name: Interleukin-1 family are secreted (Danio rerio)


name: Regulation of TLR by endogenous ligand (Xenopus tropicalis)


name: G or G analog binds C-ter TLR7 dimer (Xenopus tropicalis)


name: HMGB1 release from cells (Xenopus tropicalis)


name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)


name: TIRAP binds PIP2-rich regions in the plasma membrane (Xenopus tropicalis)


name: CASP3 cleaves GSDME (Xenopus tropicalis)


name: Interleukin-1 family are secreted (Xenopus tropicalis)


name: GSDME (1-270) binds cardiolipin (Xenopus tropicalis)


name: GSDME (1-270) binds PIPs (Xenopus tropicalis)


name: Interleukin-18 signaling (Xenopus tropicalis)


name: IL18:IL18R1 binds IL18RAP (Xenopus tropicalis)


name: Interleukin-1 processing (Xenopus tropicalis)


name: CTSG cleaves CASP1(1-404) (Xenopus tropicalis)


name: Interleukin-1 family precursors are cleaved by caspase-1 (Xenopus tropicalis)


name: Formation of caspase-1 p10/p20 dimer (Xenopus tropicalis)


name: Caspase-1 active tetramer formation (Xenopus tropicalis)


name: Regulation of TLR by endogenous ligand (Gallus gallus)


name: HMGB1 release from cells (Gallus gallus)


name: Cleaved fibrinogen products bind TLR4:LY96 (Gallus gallus)


name: SFTPA/SFTPD binds TLR2:TLR1 (Gallus gallus)


name: SFTPA/SFTPD binds TLR4:LY96 (Gallus gallus)


name: oxLDL:CD36 binds TLR4:TLR6 (Gallus gallus)


name: S100A8:S100A9 binds TLR4:LY96 (Gallus gallus)


name: G or G analog binds C-ter TLR7 dimer (Gallus gallus)


name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)


name: TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)


name: GSDME (1-270) binds PIPs (Gallus gallus)


name: Disulfiram covalently modifies Cys191 in GSDMD (Gallus gallus)


name: GSDMD oligomerizes into arc-, slit-shaped structures (Gallus gallus)


name: Dimethyl fumarate modifies Cys191 in GSDMD (Gallus gallus)


name: GSDME (1-270) binds cardiolipin (Gallus gallus)


name: GSDMD (1-275) binds bacterial cardiolipin (Gallus gallus)


name: GSDMD (1-275) binds cardiolipin (Gallus gallus)


name: GSDMD (1-275) binds PIPs (Gallus gallus)


name: CASP4, CASP5 cleave GSDMD (Gallus gallus)


name: GSDMD forms ring‐shaped oligomers  (Gallus gallus)


name: Interleukin-1 family are secreted (Gallus gallus)


name: Interleukin-18 signaling (Gallus gallus)


name: IL18:IL18R1 binds IL18RAP (Gallus gallus)


name: Interleukin-1 processing (Gallus gallus)


name: Regulation of TLR by endogenous ligand (Drosophila melanogaster)


name: HMGB1 binds LTP (Drosophila melanogaster)


name: HMGB1 binds LPS (Drosophila melanogaster)


name: HMGB1 release from cells (Drosophila melanogaster)


name: PIP3 activates AKT signaling (Drosophila melanogaster)


name: PDPK1 binds PIP2 (Drosophila melanogaster)


name: Iron uptake and transport (Drosophila melanogaster)


name: CANDI binds CUL1 (Drosophila melanogaster)


name: CYBRD1:Heme reduces Fe3+ to Fe2+ (Drosophila melanogaster)


name: FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Drosophila melanogaster)


name: HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)


name: SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Drosophila melanogaster)


name: LCN2:2,5DHBA binds Fe3+ (Drosophila melanogaster)


name: FLVCR1-1 transports heme from cytosol to extracellular region (Drosophila melanogaster)


name: ACO1 binds 4Fe-4S (Drosophila melanogaster)


name: Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Drosophila melanogaster)


name: apoTF binds 2Fe3+ to form holoTF (Drosophila melanogaster)


name: SLC46A1 transports hemes from extracellular region to cytosol (Drosophila melanogaster)


name: SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Drosophila melanogaster)


name: Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Drosophila melanogaster)


name: ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)


name: Signaling by PDGF (Drosophila melanogaster)


name: Autophosphorylation of PDGF alpha receptors (Drosophila melanogaster)


name: Autophosphorylation of PDGF beta receptors (Drosophila melanogaster)


name: Autophosphorylation of PDGF alpha/beta receptors (Drosophila melanogaster)


name: PDGFRs bind type I TKI (Drosophila melanogaster)


name: Release of novel PDGFs as latent factors (Drosophila melanogaster)


name: PDGF dimer binds two receptors simultaneously (Drosophila melanogaster)


name: PDGF-AB clevage by Furin (Drosophila melanogaster)


name: PDGF-AA clevage by Furin (Drosophila melanogaster)


name: PDGFRs bind type II TKI (Drosophila melanogaster)


name: Translocation of PDGF from ER to Golgi (Drosophila melanogaster)


name: PDGF-BB clevage by Furin (Drosophila melanogaster)


name: Downstream signal transduction (Drosophila melanogaster)


name: Activation of Src (Drosophila melanogaster)


name: Nck binds to the active PDGF receptor (Drosophila melanogaster)


name: STAT binds to the active receptor (Drosophila melanogaster)


name: GRB2:SOS1 complex binds to the active receptor (Drosophila melanogaster)


name: Phosphorylation of PLCgamma by PDGFR (Drosophila melanogaster)


name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Drosophila melanogaster)


name: SH2 domain of Src binds to the active receptor (Drosophila melanogaster)


name: Activated PLC gamma dissociates from the PDGF receptor (Drosophila melanogaster)


name: p130Cas and C3G bind PDGFR bound Crk (Drosophila melanogaster)


name: PLC-gamma binds to the active receptor (Drosophila melanogaster)


name: PI3K catalyses the phosphorylation of PIP2 to PIP3 (Drosophila melanogaster)


name: Crk binds to the active PDGF receptor (Drosophila melanogaster)


name: PI3-kinase binds to the active receptor (Drosophila melanogaster)


name: GAP binds to PDGF-beta receptors only (Drosophila melanogaster)


name: Downstream signal transduction (Homo sapiens)


name: PI3-kinase binds to the active receptor (Homo sapiens)


name: SHP2 binds to the active receptor (Homo sapiens)


name: PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)


name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)


name: Nck binds to the active PDGF receptor (Homo sapiens)


name: PLC-gamma binds to the active receptor (Homo sapiens)


name: Crk binds to the active PDGF receptor (Homo sapiens)


name: Phosphorylation of PLCgamma by PDGFR (Homo sapiens)


name: GAP binds to PDGF-beta receptors only (Homo sapiens)


name: STAT binds to the active receptor (Homo sapiens)


name: GRB2:SOS1 complex binds to the active receptor (Homo sapiens)


name: Grb7 binds to the active PDGF receptor (Homo sapiens)


name: p130Cas and C3G bind PDGFR bound Crk (Homo sapiens)


name: SH2 domain of Src binds to the active receptor (Homo sapiens)


name: Activated PLC gamma dissociates from the PDGF receptor (Homo sapiens)


name: Downstream signal transduction (Mus musculus)


name: SHP2 binds to the active receptor (Mus musculus)


name: SH2 domain of Src binds to the active receptor (Mus musculus)


name: PLC-gamma binds to the active receptor (Mus musculus)


name: PI3-kinase binds to the active receptor (Mus musculus)


name: p130Cas and C3G bind PDGFR bound Crk (Mus musculus)


name: GRB2:SOS1 complex binds to the active receptor (Mus musculus)


name: STAT binds to the active receptor (Mus musculus)


name: GAP binds to PDGF-beta receptors only (Mus musculus)


name: Nck binds to the active PDGF receptor (Mus musculus)


name: PI3K catalyses the phosphorylation of PIP2 to PIP3 (Mus musculus)


name: Phosphorylation of PLCgamma by PDGFR (Mus musculus)


name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Mus musculus)


name: Grb7 binds to the active PDGF receptor (Mus musculus)


name: Crk binds to the active PDGF receptor (Mus musculus)


name: Activated PLC gamma dissociates from the PDGF receptor (Mus musculus)


name: Downstream signal transduction (Rattus norvegicus)


name: Grb7 binds to the active PDGF receptor (Rattus norvegicus)


name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Rattus norvegicus)


name: GRB2:SOS1 complex binds to the active receptor (Rattus norvegicus)


name: Crk binds to the active PDGF receptor (Rattus norvegicus)


name: Activated PLC gamma dissociates from the PDGF receptor (Rattus norvegicus)


name: GAP binds to PDGF-beta receptors only (Rattus norvegicus)


name: SHP2 binds to the active receptor (Rattus norvegicus)


name: STAT binds to the active receptor (Rattus norvegicus)


name: SH2 domain of Src binds to the active receptor (Rattus norvegicus)


name: Phosphorylation of PLCgamma by PDGFR (Rattus norvegicus)


name: Nck binds to the active PDGF receptor (Rattus norvegicus)


name: p130Cas and C3G bind PDGFR bound Crk (Rattus norvegicus)


name: PI3K catalyses the phosphorylation of PIP2 to PIP3 (Rattus norvegicus)


name: PLC-gamma binds to the active receptor (Rattus norvegicus)


name: PI3-kinase binds to the active receptor (Rattus norvegicus)


name: Downstream signal transduction (Canis familiaris)


name: GRB2:SOS1 complex binds to the active receptor (Canis familiaris)


name: Nck binds to the active PDGF receptor (Canis familiaris)


name: SH2 domain of Src binds to the active receptor (Canis familiaris)


name: PLC-gamma binds to the active receptor (Canis familiaris)


name: PI3-kinase binds to the active receptor (Canis familiaris)


name: Grb7 binds to the active PDGF receptor (Canis familiaris)


name: Activated PLC gamma dissociates from the PDGF receptor (Canis familiaris)


name: p130Cas and C3G bind PDGFR bound Crk (Canis familiaris)


name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Canis familiaris)


name: Crk binds to the active PDGF receptor (Canis familiaris)


name: Phosphorylation of PLCgamma by PDGFR (Canis familiaris)


name: STAT binds to the active receptor (Canis familiaris)


name: GAP binds to PDGF-beta receptors only (Canis familiaris)


name: SHP2 binds to the active receptor (Canis familiaris)


name: PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)


name: Downstream signal transduction (Bos taurus)


name: Crk binds to the active PDGF receptor (Bos taurus)


name: p130Cas and C3G bind PDGFR bound Crk (Bos taurus)


name: Phosphorylation of PLCgamma by PDGFR (Bos taurus)


name: Activated PLC gamma dissociates from the PDGF receptor (Bos taurus)


name: GAP binds to PDGF-beta receptors only (Bos taurus)


name: Nck binds to the active PDGF receptor (Bos taurus)


name: SHP2 binds to the active receptor (Bos taurus)


name: PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)


name: SH2 domain of Src binds to the active receptor (Bos taurus)


name: PLC-gamma binds to the active receptor (Bos taurus)


name: PI3-kinase binds to the active receptor (Bos taurus)


name: STAT binds to the active receptor (Bos taurus)


name: GRB2:SOS1 complex binds to the active receptor (Bos taurus)


name: Grb7 binds to the active PDGF receptor (Bos taurus)


name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Bos taurus)


name: Downstream signal transduction (Sus scrofa)


name: Activated PLC gamma dissociates from the PDGF receptor (Sus scrofa)


name: Phosphorylation of PLCgamma by PDGFR (Sus scrofa)


name: Nck binds to the active PDGF receptor (Sus scrofa)


name: GAP binds to PDGF-beta receptors only (Sus scrofa)


name: SHP2 binds to the active receptor (Sus scrofa)


name: PI3K catalyses the phosphorylation of PIP2 to PIP3 (Sus scrofa)


name: STAT binds to the active receptor (Sus scrofa)


name: Grb7 binds to the active PDGF receptor (Sus scrofa)


name: Crk binds to the active PDGF receptor (Sus scrofa)


name: SH2 domain of Src binds to the active receptor (Sus scrofa)


name: PLC-gamma binds to the active receptor (Sus scrofa)


name: PI3-kinase binds to the active receptor (Sus scrofa)


name: p130Cas and C3G bind PDGFR bound Crk (Sus scrofa)


name: GRB2:SOS1 complex binds to the active receptor (Sus scrofa)


name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Sus scrofa)


name: Downstream signal transduction (Danio rerio)


name: Activated PLC gamma dissociates from the PDGF receptor (Danio rerio)


name: Crk binds to the active PDGF receptor (Danio rerio)


name: PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)


name: PI3-kinase binds to the active receptor (Danio rerio)


name: STAT binds to the active receptor (Danio rerio)


name: PLC-gamma binds to the active receptor (Danio rerio)


name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Danio rerio)


name: GRB2:SOS1 complex binds to the active receptor (Danio rerio)


name: Phosphorylation of PLCgamma by PDGFR (Danio rerio)


name: Nck binds to the active PDGF receptor (Danio rerio)


name: SH2 domain of Src binds to the active receptor (Danio rerio)


name: Downstream signal transduction (Xenopus tropicalis)


name: PLC-gamma binds to the active receptor (Xenopus tropicalis)


name: PI3-kinase binds to the active receptor (Xenopus tropicalis)


name: SHP2 binds to the active receptor (Xenopus tropicalis)


name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Xenopus tropicalis)


name: p130Cas and C3G bind PDGFR bound Crk (Xenopus tropicalis)


name: Crk binds to the active PDGF receptor (Xenopus tropicalis)


name: STAT binds to the active receptor (Xenopus tropicalis)


name: Grb7 binds to the active PDGF receptor (Xenopus tropicalis)


name: GRB2:SOS1 complex binds to the active receptor (Xenopus tropicalis)


name: PI3K catalyses the phosphorylation of PIP2 to PIP3 (Xenopus tropicalis)


name: GAP binds to PDGF-beta receptors only (Xenopus tropicalis)


name: Nck binds to the active PDGF receptor (Xenopus tropicalis)


name: Phosphorylation of PLCgamma by PDGFR (Xenopus tropicalis)


name: Activated PLC gamma dissociates from the PDGF receptor (Xenopus tropicalis)


name: Downstream signal transduction (Gallus gallus)


name: SHP2 binds to the active receptor (Gallus gallus)


name: PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)


name: GAP binds to PDGF-beta receptors only (Gallus gallus)


name: Crk binds to the active PDGF receptor (Gallus gallus)


name: STAT binds to the active receptor (Gallus gallus)


name: Nck binds to the active PDGF receptor (Gallus gallus)


name: Phosphorylation of PLCgamma by PDGFR (Gallus gallus)


name: Activated PLC gamma dissociates from the PDGF receptor (Gallus gallus)


name: GRB2:SOS1 complex binds to the active receptor (Gallus gallus)


name: p130Cas and C3G bind PDGFR bound Crk (Gallus gallus)


name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Gallus gallus)


name: SH2 domain of Src binds to the active receptor (Gallus gallus)


name: PLC-gamma binds to the active receptor (Gallus gallus)


name: PI3-kinase binds to the active receptor (Gallus gallus)


name: Downstream signal transduction (Caenorhabditis elegans)


name: Nck binds to the active PDGF receptor (Caenorhabditis elegans)


name: PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)


name: Crk binds to the active PDGF receptor (Caenorhabditis elegans)


name: STAT binds to the active receptor (Caenorhabditis elegans)


name: Activation of Src (Caenorhabditis elegans)


name: Phosphorylation of PLCgamma by PDGFR (Caenorhabditis elegans)


name: SH2 domain of Src binds to the active receptor (Caenorhabditis elegans)


name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Caenorhabditis elegans)


name: PI3-kinase binds to the active receptor (Caenorhabditis elegans)


name: GRB2:SOS1 complex binds to the active receptor (Caenorhabditis elegans)


name: RAF/MAP kinase cascade (Drosophila melanogaster)


name: Intrinsic nucleotide exchange on RAS (Drosophila melanogaster)


name: RAS:GTP binds PI3K (Drosophila melanogaster)


name: RAS:GTP binds RAL GDS proteins (Drosophila melanogaster)


name: RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)


name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Drosophila melanogaster)


name: RAS processing (Drosophila melanogaster)


name: PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Drosophila melanogaster)


name: Palmostatin B binds RAS depalmitoylases (Drosophila melanogaster)


name: KRAS4B is phosphorylated on serine 181 (Drosophila melanogaster)


name: KRAS4B recycles to the plasma membrane (Drosophila melanogaster)


name: mature RAS proteins translocate to plasma membrane (Drosophila melanogaster)


name: ICMT methylates S-Farn RAS proteins (Drosophila melanogaster)


name: USP17L2 deubiquitinates RCE1 (Drosophila melanogaster)


name: Mature S-Farn-Me KRAS4B translocates to plasma membrane (Drosophila melanogaster)


name: Calmodulin dissociates KRAS4B from the plasma membrane (Drosophila melanogaster)


name: pro-RAS proteins are farnesylated (Drosophila melanogaster)


name: ARL2:GTP bind PDE6D on KRAS4B (Drosophila melanogaster)


name: mature p21 RAS binds GDP (Drosophila melanogaster)


name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Drosophila melanogaster)


name: FNTB inhibitors bind FNTA:FNTB (Drosophila melanogaster)


name: S-Farn-Me KRAS4B binds calmodulin (Drosophila melanogaster)


name: RAS proteins are depalmitoylated (Drosophila melanogaster)


name: RCE1 cleaves S-Farn proRAS proteins (Drosophila melanogaster)


name: pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Drosophila melanogaster)


name: Neurotransmitter receptors and postsynaptic signal transmission (Drosophila melanogaster)


name: GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Drosophila melanogaster)


name: Activation of Ca-permeable Kainate Receptor (Drosophila melanogaster)


name: Activation of Ca-permeable Kainate receptors (Drosophila melanogaster)


name: kainate receptor binds glutamate (Drosophila melanogaster)


name: Activation of Ca-permeable Kainate Receptor (Homo sapiens)


name: Activation of Ca-permeable Kainate receptors (Homo sapiens)


name: kainate receptor binds glutamate (Homo sapiens)


name: Activation of Ca-permeable Kainate Receptor (Mus musculus)


name: kainate receptor binds glutamate (Mus musculus)


name: Activation of Ca-permeable Kainate receptors (Mus musculus)


name: Activation of Ca-permeable Kainate Receptor (Rattus norvegicus)


name: kainate receptor binds glutamate (Rattus norvegicus)


name: Activation of Ca-permeable Kainate receptors (Rattus norvegicus)


name: Activation of Ca-permeable Kainate Receptor (Canis familiaris)


name: kainate receptor binds glutamate (Canis familiaris)


name: Activation of Ca-permeable Kainate receptors (Canis familiaris)


name: Activation of Ca-permeable Kainate Receptor (Bos taurus)


name: kainate receptor binds glutamate (Bos taurus)