Encephalopathy of Prematurity

description: A condition affecting premature infants characterized by white matter injury, which is frequently accompanied by neuronal/axonal disease, that may affect all brain parenchymal structures and is due to a combination of destructive processes as well as maturational and trophic disturbances.


Metastatic Bladder Adenocarcinoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Bladder adenocarcinoma that has spread from its original site of growth to other anatomic sites.


Severe Aplastic Anemia

description: Life-threatening anemia associated with a high risk of infection or bleeding.


name: Refractory Extracranial Malignant Solid Neoplasm

description: An extracranial malignant solid neoplasm that is resistant to treatment.


Flat adenoma

description: An adenoma of the gastrointestinal tract mucosa which grossly and morphologically does not appear as an elevated or polypoid lesion.


name: Pathologic Stage III Esophageal Adenocarcinoma AJCC v8

description: Stage III includes: IIIA: (T1, N2, M0, Any G); (T2, N1, M0, Any G); IIIB: (T2, N2, M0, Any G); (T3, N1-2, M0, Any G); (T4a, N0-1, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Adult Solid Neoplasm

description: A solid neoplasm (e.g., carcinoma, sarcoma) occurring in adults.


Early Stage Endometrial Carcinoma

description: A stage term referring to endometrial carcinoma that is confined to the uterus.


name: Ampulla of Vater Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of an ampulla of Vater neuroendocrine tumor according to the American Joint Committee on Cancer, 8th edition. This staging system applies to well-differentiated neuroendocrine tumors of the ampulla of Vater. Carcinomas of the ampulla of Vater, including high-grade (grade 3), poorly differentiated neuroendocrine carcinomas are not included in this staging system. (from AJCC 8th Ed.)


name: Sustained Atrial Tachyarrhythmia Related to COVID-19 other than Atrial Fibrillation or Atrial Flutter

description: A supraventricular tachycardia, including AV nodal re-entry, orthodromic re-entrant tachycardia, multifocal atrial tachycardia, other atrial tachycardia that lasts more then 30 seconds in a patient with probable or confirmed acute COVID-19.


name: Ductal Eccrine Carcinoma with Spindle Cell Elements

description: A variant of ductal eccrine carcinoma with spindled cell appearance.


Pancreatic carcinoma recurrent

description: The reemergence of pancreatic carcinoma after a period of remission.


Seropositive rheumatoid arthritis

description: Rheumatoid arthritis in which a patient's serum is positive for certain disease-related antibodies including anti-cyclic citrullinated peptides (anti-CCPs), also called anti-citrullinated protein antibodies (ACPAs),and rheumatoid factor (RF). Screening for anti-CCPs is more specific than RF which can be found in other pathologic conditions. The production of these disease-associated antibodies may precede the development of clinical symptoms by several years. Seropositive patients have a greater likelihood of developing extra-articular complications and a more severe course of disease.


Spitzoid melanoma

description: A cutaneous melanoma that is associated with genomic alterations observed in Spitz nevus and Spitz melanocytoma. It shares histopathological and clinical features with Spitz melanocytoma.


Acquired Rickets

description: Rickets that is caused by vitamin D deficiency, hypocalcemia, or renal failure.


Diffuse Glioma

description: A glioma that has diffusely infiltrated the surrounding central nervous system tissues.


name: Vulvar Squamous Intraepithelial Lesion, HPV-Associated

description: An intraepithelial lesion of the vulvar squamous epithelium associated with HPV infection. It is characterized by maturation abnormalities and nuclear hyperchromasia that are confined to the basement membrane.


name: Pathologic Stage IC Esophageal Adenocarcinoma AJCC v8

description: Stage IC includes: (T1, N0, M0, G3); (T2, N0, M0, G1-2). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. G2: Moderately differentiated. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


name: Rhabdomyosarcoma with TFCP2 Rearrangement

description: An aggressive, high-grade rhabdomyosarcoma characterized by TFCP2 rearrangement that results either in TFCP2-FUS or TFCP2-EWSR1 fusion gene formation. It affects young adults and arises from bone and less frequently soft tissue. It predominantly affects the craniofacial bones. Histologically, it usually shows a biphasic pattern with spindle and epithelioid cell areas. It is associated with poor prognosis.


name: Childhood Mixed Cellularity Classic Hodgkin Lymphoma

description: Mixed cellularity classic Hodgkin lymphoma occurring in childhood.


Cebocephaly

description: A congenital abnormality characterized by a malformation of the head. The eyes are hypoteleric and the nose may be absent or misshapen (small, flattened, single nostril) and defective.


Stage I Skin Cancer

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  High-risk features for the primary tumor staging are defined as follows: depth/invasion of more than 2 mm thickness, Clark level equal or greater than IV, and perineural invasion.  Anatomic location: primary site ear and primary site non-hair-bearing lip.  Differentiation: poorly differentiated or undifferentiated.  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th ed.)


Eyelid Function Disorder

description: A disorder characterized by impaired eyelid function.


Stage IVB Prostate Cancer AJCC v8

description: Stage IVB includes: Any T, N0, M1, PSA: Any, Grade Group: Any. N0: Prostate cancer with no positive regional nodes. M1: Prostate cancer with distant metastasis. (AJCC 8th ed.)


Stage IIC Testicular Cancer AJCC v8

description: Stage IIC includes: (Any pT/TX, N3, M0, S0); (Any pT/TX, N3, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Breast Columnar Cell Lesion

description: A morphologic spectrum of lesions that arise in the terminal ductal lobular units of the breast parenchyma.  These lesions are characterized by the presence of columnar epithelial cells that line dilated terminal ductal lobular units.  Cytological and architectural atypia may be absent or minimal, or significant enough to raise the possibility of atypical ductal hyperplasia or ductal carcinoma in situ.  Columnar cell lesions are frequently found in breast biopsies but their biologic significance is not known.


Lymphoma, Mixed-Cell

description: An antiquated term that refers to a lymphoma composed of a mixture of small and large lymphocytes.


name: Lugano Classification Stage III Adult Hodgkin Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Pre-Gestational Diabetes

description: Diabetes diagnosed before current pregnancy. (reVITALize)


Type II Endometrial Adenocarcinoma

description: A classification of primary endometrial adenocarcinomas that refers to clear cell adenocarcinoma, serous adenocarcinoma, and serous endometrial intraepithelial carcinoma.


Degenerated Schwannoma

description: A schwannoma that is characterized by degenerative changes such as hyalinization, hemorrhage, calcification and cystic change.


name: Advanced Digestive System Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from any part of the digestive system and has spread extensively to other anatomic sites or is no longer responding to treatment.


Embolism

description: The blockage of a blood vessel lumen by air or solid material such as blood clot or other tissues (e.g., adipose tissue, cancer cells) that have migrated from another anatomic site.


name: Unresectable Midgut Neuroendocrine Tumor

description: A midgut neuroendocrine tumor that is not amenable to surgical resection.


Factor II Inactivation

description: Presence of inactivating antibodies to prothrombin (factor II) in the blood.


name: Pathologic Stage IB Esophageal Adenocarcinoma AJCC v8

description: Stage IB includes: (T1a, N0, M0, G2); (T1b, N0, M0, G1-2); (T1b, N0, M0, GX). T1a: Tumor invades the lamina propria or muscularis mucosae. T1b: Tumor invades the submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. G2: Moderately differentiated. (AJCC 8th ed.)


name: Fetus Small for Gestational Age with Abnormal Doppler

description: A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and has abnormal Doppler studies.


name: Metastatic squamous cell carcinoma to skin

description: A squamous cell carcinoma that has spread to the skin from another anatomic site.


name: Peripheral neuropathy due to and following antineoplastic therapy

description: Any disorder affecting the peripheral nerves resulting from exposure to chemotherapeutic agents.


Finding

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Clinical, laboratory or molecular evidence, or absence of evidence of disease.


name: Type I Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the superior vena cava.


Recurrent Diffuse Midline Glioma

description: The reemergence of diffuse midline glioma after a period of remission.


Childhood Solid Neoplasm

description: A solid neoplasm (e.g., carcinoma, sarcoma) occurring in children.


Metastatic Low Grade Glioma

description: Low grade glioma that has spread from its primary site to another anatomic site.


Unresectable Diffuse Glioma

description: A diffuse glioma that is not amenable to surgical resection.


name: Substance-Induced Persisting Amnestic Disorder

description: A disorder involving memory impairment (either anterograde or retrograde) that is etiologically linked to the persisting effects of substance use. The memory impairment persists beyond the usual duration of substance intoxication or withdrawal.


Platinum-Resistant Urothelial Carcinoma

description: Urothelial carcinoma that is resistant to platinum therapy.


Liver Lymphangiomatosis

description: Multiple lymphangiomas that affect the liver and other anatomic sites. Although histologically benign, diffuse lymphangiomatosis that affects the liver and multiple organs has a poor prognosis.


name: Supratentorial Ependymoma, Not Otherwise Specified

description: A circumscribed ependymoma that arises from the supratentorial region of the brain in which the genetic analysis for fusion genes involving ZFTA or YAP1 genes was unsuccessful or not reported.


Stage II Merkel Cell Carcinoma AJCC v7

description: Stage II includes: IIA: (T2/T3, pN0, M0), IIB: (T2/T3, cN0, M0), and IIC: (T4, N0, M0).  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  T4: Primary tumor invades bone, muscle, fascia, or cartilage.  pN0: No regional lymph node metastasis by pathologic examination.  cN0: No regional lymph node metastasis by clinical examination.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Mixed subtype adenocarcinoma of lung

description: The most frequently seen morphologic variant of lung adenocarcinoma characterized by a mixture of architectural patterns, including acinar, papillary, bronchioloalveolar, and solid pattern.


Vital Exhaustion

description: A condition characterized by excessive fatigue and lack of energy, increasing irritability, and feelings of demoralization. Persons who experience this condition are not at an increased risk for cancer.


name: Recurrent Anal Canal Squamous Cell Carcinoma

description: The reemergence of anal canal squamous cell carcinoma after a period of remission.


Stage IIA1 Cervical Cancer FIGO 2009

description: Cervical carcinoma limited to the upper two-thirds of the vagina and is equal or less than 4 cm in diameter. (FIGO 2009)


Non-Neoplastic Muscle Disorder

description: A non-neoplastic disorder that affects the smooth, skeletal, or cardiac muscles.


name: Stage III Extragonadal Non-Seminomatous Germ Cell Tumor


Vaginal Adenoid Basal Carcinoma

description: A carcinoma that arises from the vagina and is characterized by the presence of nests of basaloid cells with focal glandular formations.


Nose Deformities, Acquired

description: A non-congenital malformation of the nose.


Retinoblastoma by AJCC v8 Stage

description: A term that refers to the staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition. This staging system does not apply to central nervous system component of "trilateral retinoblastoma" (is staged according to the classification for brain and spinal cord), retinoma (or retinocytoma) (no AJCC staging system), and medulloepithelioma (no AJCC staging system). (from AJCC 8th Ed.)


name: Gallbladder Intracholecystic Papillary (Tubular) Neoplasm with Intermediate Grade Intraepithelial Neoplasia

description: An intracholecystic papillary neoplasm that arises from the epithelium of the gallbladder. It is characterized by the presence of moderate epithelial atypia.


name: Unresectable Distal Esophagus Adenocarcinoma

description: Distal esophagus adenocarcinoma that is not amenable to surgical resection.


Thoracoschisis

description: A congenital fissure of the thoracic wall.


name: Intraepithelial Neoplasia in Barrett Esophagus

description: Glandular intraepithelial neoplasia arising in Barrett esophagus.


Small plaque parapsoriasis

description: A variant of parapsoriasis in which the plaques are small.


name: Advanced Digestive System Neuroendocrine Tumor G2

description: Digestive system neuroendocrine tumor G2 that has spread extensively to other anatomic sites or is no longer responding to treatment.


Gallbladder Cribriform Carcinoma

description: A rare variant of gallbladder adenocarcinoma.  It is characterized by the presence of a malignant glandular epithelial infiltrate with a cribriform growth pattern.


name: Accelerated Phase Myeloproliferative Neoplasm

description: Rapid progression of a myeloproliferative neoplasm, characterized by the presence of myeloblasts accounting for 10-19% of the peripheral blood white cells or the nucleated cells in the bone marrow.


name: Refractory EBV-Related Lymphoproliferative Disease with Primary Immunodeficiency

description: EBV-associated lymphoproliferative disease with primary immunodeficiency that is resistant to treatment.


Overt Primary Myelofibrosis

description: Primary myelofibrosis characterized by reticulin or collagen fibrosis in the bone marrow. The bone marrow is usually normocellular or hypocellular. Myeloblasts account for less than 10% of the bone marrow cells. Atypical megakaryocytes are present.


name: Stage IIIC2 Uterine Corpus Cancer AJCC v7

description: Stage IIIC2 includes: T1-T3, N2, M0. T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue.  N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Acute Myeloid Leukemia with del(12p)

description: Acute myeloid leukemia associated with deletion of the short arm of chromosome 12 [del(12p)].


Mucosal-Dominant Pemphigus Vulgaris

description: A subtype of pemphigus vulgaris in which lesions are predominantly found on mucosal membranes with relative sparing of cutaneous tissues.


Metastatic Biliary Tract Carcinoma

description: A biliary tract carcinoma that has spread from the original site of growth to other anatomic sites.


Cervical Glandular Neoplasm

description: A benign, malignant, or precancerous neoplasm that arises from the glandular epithelium of the cervix. Representative examples include endocervical polyp, cervical adenocarcinoma, and cervical glandular intraepithelial neoplasia.


name: Metastatic Bladder Micropapillary Urothelial Carcinoma

description: Bladder micropapillary urothelial carcinoma that has spread to another anatomic site.


name: Lugano Classification Advanced Stage Adult Hodgkin Lymphoma AJCC v8

description: Advanced stage adult Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


Stage IIA Cervical Cancer FIGO 2018

description: Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement. (FIGO 2018)


Behavioral insomnia of childhood

description: A childhood disorder characterized by difficulty initiating and maintaining sleep due to negative sleep associations, refusal to go to bed, and/or repeated attempts to delay bedtime.


name: Malignant Central Nervous System Germ Cell Tumor

description: A germ cell tumor that affects the central nervous system, characterized by the presence of malignant morphologic characteristics.  Representative examples include choriocarcinoma, embryonal carcinoma, and germinoma.


Hodgkin's lymphoma of CNS

description: A Hodgkin lymphoma that arises from the central nervous system.


Vaginal Mucinous Adenocarcinoma

description: A rare adenocarcinoma that arises from the vagina with histologic features resembling cervical mucinous adenocarcinoma.


Posterior Subcapsular Cataract Grade 1

description: A stage of posterior subcapsular cataract characterized by 3% of the posterior capsule obscured by opacity. (Modified LOCS II)


Infant Acute Lymphoblastic Leukemia

description: An acute lymphoblastic leukemia that occurs in infancy.


name: Simple Endometrial Hyperplasia without Atypia

description: A proliferation of endometrial cells resulting in glandular enlargement and budding without changes in the basic structure of the endometrium. Epithelial atypia is absent.


name: Locally Advanced Epithelioid Hemangioendothelioma

description: An epithelioid hemangioendothelioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Neonatal Deformity

description: A congenital anatomic abnormality manifested during the neonatal period.


name: Stage IIIB Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of lymph node regions on both sides (above and below) of the diaphragm. This may be accompanied by extra-lymphatic extension in association with adjacent lymph node involvement (i.e., local extension from a lymph node area into a nearby organ) and/or involvement of spleen. The medical record states there are constitutional symptoms. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Breast Papillary Ductal Hyperplasia

description: Benign papillary proliferation within the ductal system of the breast parenchyma.


Benign Urinary Tract Neoplasm

description: A neoplasm that arises from the organs that comprise the urinary tract and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Somatic-Type Malignancy

description: A malignant non-germ cell component that typically develops secondarily within a germ cell tumor. The malignant cellular component is usually sarcomatous or carcinomatous.


Stage IIB Pancreatic Cancer AJCC v8

description: Stage IIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. N1: Metastasis in one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Non-Neoplastic Thymus Disorder

description: A non-neoplastic disorder that affects the thymus.  Representative examples include acute thymic involution and thymic hyperplasia.


name: Postoperative Spindle Cell Nodule of the Bladder

description: A benign, reactive lesion of the bladder, occurring status post bladder instrumentation; histologic exam demonstrates a fascicular growth pattern of plump or elongated spindle cells infiltrating the bladder wall without atypia or necrosis.


Microinvasive Anal Carcinoma

description: Anal carcinoma with minimal stromal invasion.


Melanoma of Unknown Primary

description: A melanoma which has metastasized from an unknown primary anatomic site.


Unresectable Malignant Neoplasm

description: A malignant neoplasm which is not amenable to surgical resection.


POLG-Related Spectrum Disorders

description: A group of disorders with overlapping phenotypes caused by mutation(s) of the POLG gene, encoding DNA polymerase subunit gamma-1. Phenotypic variations include Alpers-Huttenlocher syndrome (AHS), childhood myocerebrohepatopathy spectrum (MCHS), myoclonic epilepsy myopathy sensory ataxia (MEMSA), ataxia neuropathy spectrum (ANS), autosomal recessive progressive external ophthalmoplegia (arPEO), and autosomal dominant progressive external ophthalmoplegia (adPEO).


Stage IV Osteosarcoma AJCC v7

description: Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


name: Locally Advanced Pancreatic Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IIIB Appendix Carcinoma AJCC v7

description: Stage IIIB includes: (T3, N1, M0); (T4, N1, M0). T3: Tumor invades through the muscularis propria into subserosa or into mesoappendix.  T4: Tumor penetrates visceral peritoneum including mucinous peritoneal tumor within the right lower quadrant and/or directly invades other organs or structures.  N1: Metastasis in 1-3 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Dialysis Catheter Embolism

description: An obstruction of a vessel caused by a detached fragment of an indwelling dialysis catheter.


name: Pathologic Stage 0 Cutaneous Melanoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Fusion-Negative Rhabdomyosarcoma

description: A rhabdomyosarcoma characterized by the absence of chromosomal translocation t(1;13)(p36;q14) or t(2;13)(q35;q14) and therefore the absence of PAX7-FOXO1 or PAX3-FOXO1 gene fusion.


name: Metastatic Bladder Squamous Cell Carcinoma

description: Bladder squamous cell carcinoma that has spread to another anatomical site.


name: Transplant-Related Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises in a patient with a history of organ transplantation.


Refractory Anaplastic Oligodendroglioma

description: An anaplastic oligodendroglioma that is resistant to treatment.


name: Acute Myeloid Leukemia with Mutated TP53

description: Acute myeloid leukemia characterized by the presence of TP53 gene mutations. There are 20% or more blasts in bone marrow or peripheral blood.


Accessory Urethral Gland Neoplasm

description: A benign or malignant, primary or metastatic neoplasm affecting the accessory urethral gland.


Stage II Gallbladder Cancer AJCC v6

description: Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N0, M0); (T2, N0, M0); (T3, N0, M0).  T2: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, or pancreas, omentum or extrahepatic bile ducts. (AJCC 6th ed.)


name: Ampulla of Vater Undifferentiated Carcinoma

description: An aggressive carcinoma arising from the ampulla of Vater.  Morphologically, it is characterized by the presence of malignant epithelial cells without evidence of glandular or squamous differentiation.  Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss.


name: Clinical Stage II Retinoblastoma AJCC v8

description: Stage II includes: cT4a, cN0, cM0, Any H. cT4a: Radiologic evidence of retrobulbar optic nerve involvement or thickening of optic nerve or involvement of orbital tissues. cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Peripheral Hemangioblastoma

description: A hemangioblastoma that arises from peripheral nerves or extraneural tissues.


Non-Ossifying Fibroma

description: A tumor histologically indistinguishable from, but larger than, benign fibrous histiocytoma of bone.


name: Hodgkin's Paragranuloma Involving Spleen

description: An obsolete term that includes cases currently classified as nodular lymphocyte predominant Hodgkin lymphoma with splenic involvement.


Stage IB1 Cervical Cancer AJCC v8

description: Stage IB1 includes: T1b1, Any N, M0. T1b1: Tumor with clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Cervical Cancer AJCC v8

description: Stage IIA includes: T2a, Any N, M0. T2a: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


BRCA-Associated Malignant Neoplasm

description: A malignant neoplasm caused by deleterious germline mutation in a gene of the BRCA family.


Tachyarrhythmia

description: A disorder characterized by an arrhythmia with an above normal rate.


name: Recurrent Low Grade Endometrioid Adenocarcinoma

description: The reemergence of low-grade endometrioid adenocarcinoma after a period of remission.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Tier 1, International Society of Pediatric Oncology (SIOP) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the tier 1 Toronto childhood cancer staging guidelines v2, International Society of Pediatric Oncology (SIOP) protocol.


Benign Apocrine Neoplasm

description: An epithelial neoplasm that arises from the apocrine glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Non-Neoplastic Tracheal Disorder

description: A non-neoplastic disorder that affects the trachea.  Representative examples include tracheitis, tracheal agenesis, and tracheal atresia.


Gastroblastoma

description: A very rare biphasic tumor arising in the gastric muscularis propria (usually of the antrum), generally in boys and young men. It is associated with MALAT1-GLI1 gene fusion. (WHO 2019)


Cheilognathoschisis

description: A congenital abnormality consisting of a fissure in the midline of the lip and upper jaw.


Villous Adenoma of the Urinary Tract

description: An exophytic glandular neoplasm of the urinary tract, morphologically similar to its intestinal counterpart. It usually arises from the bladder and urachus. It often coexists with in situ or infiltrating bladder adenocarcinoma.


Non-Neoplastic Axillary Disorder

description: A non-neoplastic disorder that affects the structures of the axilla.  Representative examples include axillary lymphadenitis and axillary abscess.


Primary Cutaneous NUT Adnexal Carcinoma

description: A very rare carcinoma that arises from adnexal structures in the skin. It is characterized by mutations and rearrangement of the NUT gene. It presents as a papular or nodular lesion and has been described in the hand, shoulder, trunk, and lower limb. Histologically, there is a proliferation of malignant epithelial cells in the dermis and/or subcutaneous tissue. The tumor cells display round nuclei with prominent single nucleoli. Features include the presence of small round ducts and foci of abrupt keratinization.


Hemoglobin Trait

description: A condition in which a person is heterozygous for a globin gene, with a one normal allele and one defective allele.


HIV lipodystrophy

description: A neoplastic process characterized by a diffuse poorly circumscribed overgrowth of adipose tissue in the breast and cervical areas, and an accumulation of visceral fat.  It is associated with antiretroviral therapy.  Clinical presentation includes hyperlipidemia, insulin resistance, and fat atrophy of the face and limbs.


Cortical Cataract Grade 1

description: A stage of cortical cataract characterized by 10% of the intrapupillary space obscured by opacity. (Modified LOCS II)


Stage I Uterine Corpus Cancer AJCC v6

description: Stage I includes: I (T1, N0, M0); IA: (T1a, N0, M0); IB (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor confined to corpus uteri. T1a: Tumor limited to the endometrium.  T1b: Tumor invades less than one-half of the myometrium.  T1c: Tumor invades one-half or more of the myometrium.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Acute synovitis

description: An acute inflammation of a synovial membrane. It is associated with swelling and pain in the affected area.


Stage IIB Anal Cancer AJCC v8

description: Stage IIB includes: T3, N0, M0. T3: Tumor larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Mucosal Melanoma

description: Mucosal melanoma that has spread from its primary site to another anatomic site.


name: Recurrent Childhood Anaplastic Oligodendroglioma

description: The reemergence of anaplastic oligodendroglioma in childhood after a period of remission.


name: Malignant neoplasm arising from pre-existing spiradenocylindroma

description: A carcinoma that arises in a spiradenocylindroma.


name: Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with High Grade Dysplasia

description: An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized by the presence of high grade dysplasia.


Lithium Induced Birth Defect

description: Congenital abnormalities, mainly cardiovascular malformations, which develop in a fetus when the mother uses lithium medication during pregnancy.


name: Metastatic Vaginal Squamous Cell Carcinoma

description: Vaginal squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


name: Platinum-Refractory Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that progresses during platinum therapy or within one month of completing platinum therapy.


Factor XII Inactivation

description: Presence of inactivating antibodies to factor XII in the blood.


name: Papillary cystadenoma, borderline malignancy

description: A serous or mucinous cystic glandular epithelial neoplasm of low malignant potential. It is characterized by the presence of atypical or malignant glandular epithelial cells forming papillary structures with an absence of stromal invasion.


name: Metastatic Unresectable Malignant Neoplasm

description: A malignant neoplasm that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


name: Benign Outer Hair Sheath and Infundibulum Neoplasm

description: A neoplasm that arises from the outer hair sheath and infundibulum. It is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Female Reproductive System Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle neoplasm that arises from any part of the female reproductive system and cannot be reliably diagnosed as benign or malignant because of the presence of ambiguous morphologic findings.


Lymphoma, Intermediate-Grade

description: An antiquated term that refers to a non-Hodgkin lymphoma with intermediate grade histologic features.


Non-Neoplastic Splenic Disorder

description: A non-neoplastic disorder that affects the spleen.


SUR1-Associated Diabetes Mellitus

description: Diabetes mellitus caused by activating mutation(s) in the ABCC8 gene, encoding the sulfonylurea receptor 1 (SUR1) subunit of the pancreatic beta cell adenosine triphosphate-sensitive potassium channel. Note: Inactivating mutation(s) in the ABCC8 gene result in hyperinsulinism.


name: Stage II Adult Diffuse Large Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Acute Myeloid Leukemia with del(5q)

description: Acute myeloid leukemia associated with deletion of the long arm of chromosome 5 [del(5q)].


name: Acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22) CBFB-MYH11

description: An acute myeloid leukemia with monocytic and granulocytic differentiation and the presence of a characteristically abnormal eosinophil component in the bone marrow.  This type of acute myeloid leukemia has a favorable prognosis.  (WHO, 2001)


name: Mucosal Melanoma of the Female Genital Tract

description: A malignant melanocytic neoplasm that arises from a mucosal site of the female genital tract.


name: immune effector cell-associated neurotoxicity syndrome, grade 1

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 7, 8, or 9 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of less than 9 (for children 12 and under), and the ability of the affected individual to awaken spontaneously.


name: Metastatic Extracranial Malignant Solid Neoplasm

description: A malignant solid neoplasm that arises from any anatomic site other than the brain and has spread from its original site of growth to another anatomic site.


name: Gestational Trophoblastic Tumor by FIGO Stage


name: IgG4-Positive Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: A primary cutaneous marginal zone lymphoproliferative disorder characterized by the presence of class-switched immunoglobulin heavy chain expressing IgG4.


name: Transitional Cell Intraepithelial Neoplasia


Abscess of axilla

description: A collection of pus that has formed in the axilla.


Atheroembolism of renal arteries

description: A cholesterol plaque embolus that has become lodged in the renal vasculature.


name: Malignant Lacrimal Drainage System Neoplasm

description: A primary or metastatic malignant neoplasm that affects the lacrimal drainage system.


Parasite-Related Malignant Neoplasm

description: A malignancy in which there is a well-documented association between a neoplastic process and a specific parasite as the causative agent.


Spongioblastoma, Polar

description: A lesion characterized by the presence of neoplastic neuroepithelial cells with palisading nuclei. This lesion implies a morphologic growth pattern and it is not considered a clinicopathological entity.


name: Gastroesophageal Junction Small Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction.  It is characterized by the presence of malignant small cells.


Atrophy of breast

description: Involution of the breast parenchyma.


name: Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8

description: Stage IVA includes: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Regional Childhood Retinoblastoma by Toronto Guidelines v2

description: Orbital extension or regional lymph nodes involvement. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Monoclonal B-Cell Lymphocytosis

description: A monoclonal expansion of B-lymphocytes with or without the characteristic immunophenotype of chronic lymphocytic leukemia. It precedes virtually all cases of chronic lymphocytic leukemia/small lymphocytic lymphoma.


Recurrent Adenocarcinoma

description: An adenocarcinoma that has recurred after a period of remission.


name: intraepithelial glandular neoplasia of cervix

description: A neoplastic process that affects the glandular epithelial cells of the cervix.  There is no evidence of invasion.  It is classified as low or high grade.


name: Advanced Childhood Malignant Solid Neoplasm

description: A childhood malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Keratinizing Primary Intraosseous Squamous Cell Carcinoma-Solid Type

description: A squamous cell carcinoma that arises centrally from the jaw.  It is characterized by a solid pattern, keratin production, infiltration of the marrow spaces, and osseous resorption.


Advanced Squamous Cell Carcinoma

description: Squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Radiation-Related Angiosarcoma

description: A malignant vascular neoplasm arising in an anatomic site exposed to radiation therapy.


name: Nutritional Vitamin D Deficiency Rickets

description: Nutritional rickets due to dietary deficiency of vitamin D.


Ureteral Kinking

description: The folding of a ureter, which results in the impediment of urine flow.


Urethral caruncle

description: A benign, granulomatous lesion that results from the eversion of a portion of the distal urethra, most often at the posterior edge.


Pancreatic Precancerous Condition

description: A pathologic process that arises from the pancreas and has the potential to evolve into a malignant neoplasm.


Stage III Appendix Carcinoma AJCC v8

description: Stage III includes: IIIA: (T1, N1, M0); (T2, N1, M0); IIIB: (T3, N1, M0); (T4, N1, M0); IIIC: (Any T, N2, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4: Tumor invades the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or mesoappendix, and/or directly invades adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. N2: Four or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Merkel Cell Carcinoma

description: The reemergence of Merkel cell carcinoma after a period of remission.


Acute rheumatic endocarditis

description: Inflammation of the endocardium in acute rheumatic heart disease.


Refractory Spindle Cell Sarcoma

description: Spindle cell sarcoma that is resistant to treatment.


Stage I Vulvar Cancer AJCC v6

description: Stage I includes: T1, N0, M0. T1: Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.).


name: Hodgkin's Disease, Lymphocyte Depletion, Diffuse Fibrosis

description: A lymphocyte depleted Hodgkin lymphoma characterized by the presence of diffuse fibrosis and a few Hodgkin and Reed-Sternberg cells.


Refractory Ampulla of Vater Carcinoma

description: Ampulla of Vater carcinoma that is resistant to treatment.


name: Acute Myeloid Leukemia with EZH2 Mutation

description: An acute myeloid leukemia associated with EZH2 gene mutation.


name: Stage II Pancreatic Cancer AJCC v6 and v7

description: Stage II includes: IIA (T3, N0, M0); IIB (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Tumor limited to the pancreas 2 cm or less in greatest dimension.  T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension. T3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery.  N0: No regional lymph node metastasis. N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


Visual Pathway Melanocytoma

description: A benign neoplastic melanocytic proliferation affecting the optic disk and optic nerve.


name: Metastatic Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that has spread from its original site of growth to other anatomic sites.


name: Recurrent Childhood Acute Lymphoblastic Leukemia

description: The reemergence of acute lymphoblastic leukemia in childhood after a period of remission.


name: Childhood Diffuse Astrocytoma, MYBL1-Altered

description: A rare diffuse astrocytoma, MYBL1-altered that occurs during childhood.


Appendix Intraepithelial Neoplasia

description: A precancerous intraepithelial neoplastic lesion that affects the appendix. It is characterized by low or high grade dysplasia of the mucosal epithelium.  There is no evidence of invasion.


Vaginal intraepithelial neoplasia

description: A superficial neoplastic process involving exclusively the vaginal squamous epithelium without extension to underlying tissue.  It is classified as low- or high-grade intraepithelial neoplasia.


Recurrent Sarcoma

description: The reemergence of sarcoma after a period of remission.


Locally Advanced Glioma

description: Glioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Infective conjunctivitis

description: An infectious process affecting the conjunctiva.


Acute Cerebrovascular Accidents

description: The sudden or severe onset of neurological deficit(s) attributable to an acute focal vascular injury of the central nervous system.


Childhood Grade III Meningioma

description: A grade III meningioma that occurs during childhood.


name: Refractory Juvenile Myelomonocytic Leukemia

description: Juvenile myelomonocytic leukemia that is resistant to treatment.


Benign Lymphoproliferative Disorder

description: A proliferation of lymphocytes without atypia seen in infections, hypersensitivity reactions or autoimmune diseases.


Bronchial Epithelial Hyperplasia

description: Hyperplasia of the bronchial epithelial cells.  It is often associated with squamous metaplasia.


Inverted Squamous Cell Papilloma

description: A benign epithelial neoplasm characterized by an endophytic growth, papillary pattern, and proliferation of neoplastic squamous cells without morphologic evidence of malignancy.


name: Refractory Endometrial Mixed Cell Adenocarcinoma

description: Endometrial mixed cell adenocarcinoma that is resistant to treatment.


description: A non-neoplastic disorder arising in an anatomic site exposed to radiation.


Refractory Malignant Solid Neoplasm

description: A malignant solid neoplasm that does not respond to treatment.


Unresectable Bone Sarcoma

description: Bone sarcoma that is not amenable to surgical resection.


name: Childhood Nodular Sclerosis Classic Hodgkin Lymphoma

description: Nodular sclerosis classic Hodgkin lymphoma occurring in childhood.


name: Stage IIB Ampulla of Vater Cancer AJCC v8

description: Stage IIB includes: T3b, N0, M0. T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Advanced Malignant Testicular Germ Cell Tumor

description: A malignant testicular germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Phrenic nerve lesion

description: Intermittent, incomplete or complete paralysis with or without tremors to any of the organs or body parts innervated by the phrenic nerve.


name: Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IIIB includes: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Delusional disorder, jealous type

description: A subtype of delusional disorder characterized by the central delusional theme that the individual's spouse or lover is unfaithful.


name: Immune Effector Cell Associated Neurotoxicity Syndrome Grade 5

description: Death due to Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) where another cause is not the primary determinant.


Childhood Astrocytoma

description: An astrocytoma that occurs during childhood.


name: Advanced Large Cell Neuroendocrine Carcinoma

description: Large cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Gastroesophageal Junction Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


name: Stage 0 Low Grade Appendix Mucinous Neoplasm (LAMN) AJCC v8

description: Stage 0 includes: Tis(LAMN), N0, M0. Tis(LAMN): Low-grade appendiceal mucinous neoplasm confined by the muscularis propria. Acellular mucin or mucinous epithelium may invade into the muscularis propria. T1 and T2 are not applicable to LAMN. Acellular mucin or mucinous epithelium that extends into the subserosa or serosa should be classified as T3 or T4a, respectively. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Hodgkin's disease nodular sclerosis recurrent

description: The reemergence of nodular sclerosis classic Hodgkin lymphoma after a period of remission.


Metastatic Urachal Urothelial Carcinoma

description: Bladder urachal urothelial carcinoma that has spread to another anatomic site.


Stage IIIC Prostate Cancer AJCC v8

description: Stage IIIC includes: Any T, N0, M0, PSA: Any, Grade Group 5. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 5: Gleason Score 9 or 10, Gleason Pattern 4+5, or 5+4, or 5+5. (AJCC 8th ed.)


Stage III Prostate Cancer AJCC v6

description: Stage III includes: T3, N0, M0, Any G. T3: Tumor extends through the prostatic capsule.  T3a: Extracapsular extension (unilateral or bilateral).  T3b: Tumor invades seminal vesicle(s). N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


name: Metastatic Digestive System Neuroendocrine Tumor

description: A digestive system neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


name: Stage IV Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Hematogenous metastases or spread beyond abdomen at diagnosis. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Recurrent Childhood Large Cell Lymphoma

description: The reemergence of childhood large cell lymphoma after a period of remission.


Stage III Uterine Corpus Cancer

description: Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T1-T3, N1/N2, M0); IIIC1 (T1-T3, N1, M0); IIIC2 (T1-T3, N2, M0). T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. T3a: Tumor involves serosa and/or adnexa (direct extension or metastasis). T3b: Tumor involves vagina (direct extension or metastasis) or parametrial tissue. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Infantile Myofibroma

description: A benign, localized, nodular and well-circumscribed neoplasm seen as a congenital neoplasm or in the first year of life. It is characterized by a biphasic growth pattern and is composed of small, undifferentiated mesenchymal cells associated with branching thin-walled vessels and more mature neoplastic spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma.


name: Vulvar Large Cell Neuroendocrine Carcinoma

description: A high grade neuroendocrine carcinoma that arises from the vulva. It is characterized by the presence of malignant large cells.


BAP1-inactivated melanocytoma

description: A cutaneous melanocytoma caused by the inactivation of BAP1 tumor suppressor gene. It is characterized by the presence of a predominantly intradermal proliferation of large epithelioid melanocytes with a large amount of eosinophilic cytoplasm, and vesicular nuclei with prominent nucleoli. Progression to melanoma is infrequent.


name: Recurrent Malignant Female Reproductive System Neoplasm

description: The reemergence of a malignant female reproductive system neoplasm after a period of remission.


Bilateral Carcinoma

description: A carcinoma that affects both sides of an organ in a simultaneous or non-simultaneous manner.


Stage IVA Bone Cancer AJCC v8

description: Stage IVA includes: Any T, N0, M1a, Any G. N0: No regional lymph node metastasis. M1a: Metastasis in the lung. (AJCC 8th ed.)


name: Squamous cell carcinoma, small cell, nonkeratinizing

description: A squamous cell carcinoma composed of small atypical cells, without morphologic evidence of keratin production.


Adipose Tissue Atrophy

description: Shrinking of adipose tissue.


Unresectable Biliary Tract Carcinoma

description: Biliary tract carcinoma that is not amenable to surgical resection.


Acute Myeloid Leukemia with FIP1L1-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of FIP1L1-RARA fusion protein.


Prostate Cystadenoma

description: A rare cystadenoma affecting the prostate gland. It is characterized by the presence of multilocular prostatic cysts.


Metastatic glioma

description: Glioma that has spread from its original site of growth to another anatomic site.


name: Poor Prognosis Metastatic Gestational Trophoblastic Tumor

description: Metastatic gestational trophoblastic tumor in which risk factors are present.


Hodgkin Lymphoma During Pregnancy

description: Hodgkin lymphoma that occurs during pregnancy.


name: Vaginal Adenocarcinoma of Skene Gland Origin

description: A rare vaginal adenocarcinoma arising from the Skene gland. It is characterized by morphological and immunohistochemical features similar to prostate adenocarcinoma.


Thoracic meningomyelocele

description: A congenital abnormality in the thoracic region of the spine, in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Adenocarcinoma of the prostate stage IV

description: Stage IV includes: (T4, N0, M0, Any PSA, Any Gleason); (Any T, N1, M0, Any PSA, Any Gleason); (Any T, Any N, M1, Any PSA, Any Gleason). cT4: Tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall.  pT4: Invasion of rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 7th ed.)


Central Nervous System Hamartoma

description: A hamartoma that occurs in the central nervous system.


Advanced Malignant Solid Neoplasm

description: A malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Dermatitis due to unspecified substance taken internally

description: Dermatitis caused by an allergic reaction to an unspecified ingested substance.


Advanced Fibrosarcoma

description: Fibrosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Necrotic tumor

description: A neoplasm characterized by focal or diffuse tumor cell necrosis.


Cutaneous Erdheim-Chester Disease

description: Erdheim-Chester disease that affects the skin.


Conventional Alveolar Rhabdomyosarcoma

description: An alveolar rhabdomyosarcoma characterized by the presence of large striated muscle cells with clear cytoplasm, giant cells with myoblastic differentiation, and fibrovascular septa.


name: Stage IIIC Fallopian Tube Cancer AJCC v7

description: Stage IIIC includes: (T3c, N0, M0); (Any T, N1, M0).  T3c: Peritoneal metastasis outside the pelvis and more than 2 cm in diameter.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Congenital Varicella Zoster Infection

description: An infection, characterized by the rash of chickenpox or shingles, that is caused by the varicella-zoster virus transmitted directly from the mother to the fetus or neonate during late pregnancy or childbirth.


name: Plasmacytic Hyperplasia Post-Transplant Lymphoproliferative Disorder

description: An early post-transplant lymphoproliferative lesion characterized by plasmacytic proliferation and architectural preservation of the involved tissues.  It often regresses either spontaneously or after reduction in immunosuppression.  The immunoglobulin genes are not rearranged.  In some cases, a polymorphic or monomorphic post-transplant lymphoproliferative disorder may follow this early lesion.


name: Hodgkin's disease nodular sclerosis stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Retroperitoneal abscess

description: An abscess that is located in the abdominal cavity posterior to the peritoneum.


name: Stage II Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of two or more lymph node regions on the same side (either above or below) of the diaphragm or localized involvement of a single extra-lymphatic organ or site in association with regional lymph node involvement (i.e., local extension from a lymph node area into a nearby organ), with or without involvement of other contiguous lymph node regions on the same side (either above or below) of the diaphragm. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Unresectable Transitional Cell Carcinoma

description: A transitional cell carcinoma which is not amenable to surgical resection.


Congenital Intrahepatic Biliary Atresia

description: A congenital disorder characterized by blockage or absence of the intrahepatic bile ducts.


Recurrent Cytomegalovirus Infection

description: A cytomegalovirus infection that has recurred after a period of remission.


name: Childhood Benign Digestive System Neoplasm

description: A childhood neoplasm that arises from the digestive system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Recurrent Extrapulmonary Neuroendocrine Carcinoma

description: The reemergence of extrapulmonary neuroendocrine carcinoma after a period of remission.


Unresectable Angiosarcoma

description: An angiosarcoma that is not amenable to surgical resection.


description: An autosomal dominant condition caused by mutation(s) in the PIK3R2 gene, encoding phosphatidylinositol 3-kinase regulatory subunit beta. It is characterized by mild to severe intellectual disability, megencephaly, polymicrogyria, and postaxial polydactyly.


name: Reactive Epithelial Hyperplasia of the Ciliary Body

description: An increase in cell number and volume of the ciliary epithelium, usually in response to injury. (WHO 2018)


Lacrimal Drainage System Adenocarcinoma

description: An adenocarcinoma that arises from the lacrimal sac or nasolacrimal duct.


name: Refractory Epithelioid Malignant Peripheral Nerve Sheath Tumor

description: An epithelioid malignant peripheral nerve sheath tumor that does not respond to treatment.


No Cardiac Valve Regurgitation

description: No evidence of any retrograde blood flow through the valve(s) in the heart. (ACC)


name: Lacrimal Drainage System Inverted Papilloma

description: A benign neoplasm of the lacrimal drainage system characterized by an inverted/endophytic or mixed growth pattern. It is the most common epithelial neoplasm of the lacrimal drainage system. (WHO 2018)


Locally Recurrent Endometrial Carcinoma

description: The reemergence of endometrial carcinoma after a period of remission, at or adjacent to the site of the original tumor.


description: A hepatocellular adenoma caused by activating mutations of beta-catenin.  It is characterized by the presence of nuclear atypia and absence of inflammation or steatosis.  There is an increased risk of malignant transformation.


name: Ancylostomiasis due to Ancylostoma duodenale

description: Ancylostomiasis that is caused by infection by Ancylostoma Duodenale.


Stage IV Childhood Hodgkin Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Stage IB Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of a single lymph node region or involvement of a single extra-lymphatic organ or site, without lymph node involvement. The medical record states there are constitutional symptoms. This definition applies to both tiers (tier 1 and 2).  (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Acute Myeloid Leukemia with RAM Immunophenotype

description: A high risk pediatric acute myeloid leukemia with an extremely poor prognosis. The blasts show bright CD56 expression, dim-to-negative expression of CD45 and CD38, and lack of HLA-DR expression. This immunophenotype was named after one of the pediatric patient's initials (RAM), from Children's Oncology Group (COG) clinical trial AAML0531.


Vaginal Endometrioid Adenocarcinoma

description: A rare adenocarcinoma that arises from the vagina with histologic features resembling the endometrioid adenocarcinoma of the endometrium.


Late Disseminated Lyme Disease

description: A late stage of Lyme disease that may present in untreated patients months to years after a tick bite manifested with intermittent bouts of arthralgia, arthritis and neurologic complaints.


name: Cervical Squamous Cell Carcinoma, Not Otherwise Specified

description: Cervical squamous cell carcinoma in which information on the p16 immunohistochemistry or HPV testing status is not available.


Stage IIB Prostate Cancer AJCC v7

description: Stage IIB includes: (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T2c: Tumor involves both lobes.  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


Dialysis Catheter Infection

description: A local or systemic infection associated with the use of a dialysis catheter.


name: Recurrent Pancreatic Ductal Adenocarcinoma

description: The reemergence of pancreatic ductal adenocarcinoma after a period of remission.


Vaginal Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the vagina. Representative examples include vaginal infection and vaginal fibroepithelial polyp.


Malignant neoplasm of stomach stage II

description: Stage II includes: IIA (T3, N0, M0); (T2, N1, M0); (T1, N2, M0); IIB (T4a, N0, M0); (T3, N1, M0); (T2, N2, M0); (T1, N3, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


Nasal Chondromesenchymal Hamartoma

description: A very rare benign lesion that arises from the sinonasal tract. It usually affects infants and children. It presents as a polypoid mass and is composed of cartilage, myxoid stroma, and other mesenchymal elements.


Puerperal endometritis

description: Infection of the endometrium, decidua and/or myometrium occurring at any time between birth and 42 days postpartum.


Superficial spreading adenocarcinoma

description: An adenocarcinoma which has spread within the mucosa without further invasion of the underlying tissues.


name: Stage IV Pancreatic Neuroendocrine Tumor AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Biliary Intraepithelial Neoplasia

description: A neoplastic, non-invasive lesion that affects the biliary epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


name: Large B-cell lymphoma arising in HHV8 associated multicentric Castleman disease

description: An aggressive diffuse large B-cell lymphoma occurring in patients with HHV8-positive multicentric Castleman disease. It is characterized by the presence of human herpesvirus 8-infected large B-lymphocytes that resemble plasmablasts. It is usually seen in patients with HIV infection.


Hypertensive Urgency

description: Hypertensive crisis without end-organ damage.


name: Verrucous carcinoma of the oral cavity stage II


Recurrent Anaplastic Ganglioglioma

description: The reemergence of anaplastic ganglioglioma after a period of remission.


Adrenoleukodystrophy, Neonatal

description: A rare metabolic disorder that affects neonates. It is characterized by damage of the white matter in the brain and degeneration of the adrenal glands. It manifests with hyperactivity, paralysis, muscular weakness, crossed eyes, hearing loss, seizures, and coma.


Wound dehiscence

description: Splitting of the sutured margins of a surgical wound. Risk factors include diabetes mellitus, obesity, and advanced age.


Cribriform comedo-type adenocarcinoma

description: An adenocarcinoma characterized by the presence of malignant cribriform glands with central necrotic changes.


name: Pancreatic Intraductal Tubulopapillary Neoplasm

description: An epithelial neoplasm that arises from the exocrine pancreas characterized by the formation of tubular structures, high grade dysplasia, and ductal differentiation. Grossly, it is characterized by the presence of intraductal nodular masses. Morphologically, there are nodules of tubular glands and occasional papillary structures growing in dilated ducts.  There is no significant mucin production. Signs and symptoms include epigastric pain, weight loss, vomiting, steatorrhea, and diabetes mellitus.


description: Cancer that is not dependent upon the presence of estrogen for metastasis or growth. 2005


Maternal Obesity

description: Obesity in a female who has a child.


Atrophy of vagina

description: A condition characterized by the absence of squamous maturation in the vaginal epithelium. It is associated with decreased estrogen production.


Stage IIIA Cervical Cancer AJCC v8

description: Stage IIIA includes: T3a, Any N, M0. T3a: Tumor involving the lower third of vagina but not extending to pelvic wall. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IB2 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 5 mm in depth and more than 4 cm in maximum diameter. (FIGO 2009)


Anal Mucositis

description: An inflammatory process affecting the mucous membrane of the anus.


name: Stage I Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Pheochromocytoma measuring less than 5 cm in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Recurrent Anaplastic Oligodendroglioma

description: The reemergence of anaplastic oligodendroglioma after a period of remission.


Prolonged grief disorder

description: A psychiatric disorder characterized by the personal experience of intense and prolonged yearning for, or preoccupation with the circumstances surrounding, a loss that leads to significant impairment in social or occupational functioning. Associated symptoms may include: identity disruption, disbelief, avoidance of reminders, difficulty moving on, emotional pain or numbness, feeling that life is meaningless, and loneliness.


BK virus infection

description: An infection caused by the BK virus. It usually causes an asymptomatic infection, except in immunocompromised individuals where it may cause nephropathy or hemorrhagic cystitis.


Metastatic Cutaneous Melanoma

description: A melanoma that arises from the skin and has metastasized to another anatomic site.


name: IgG-Positive Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: A primary cutaneous marginal zone lymphoproliferative disorder characterized by the presence of class-switched immunoglobulin heavy chain expressing IgG.


name: Recurrent Moderate-Severe Chronic Graft Versus Host Disease

description: The reemergence of moderate-severe chronic graft versus host disease after a period of remission.


Locally Advanced Bone Sarcoma

description: Bone sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Factor X Inactivation

description: Presence of inactivating antibodies to factor X in the blood.


Dendritic Blue Nevus

description: A blue nevus characterized by the proliferation of dendritic melanocytes in sclerotic stromal collagen.


Megaureter

description: Enlargement of the diameter of the ureter, which can be partial or complete.


name: Refractory Malignant Peripheral Nerve Sheath Tumor

description: Malignant peripheral nerve sheath tumor that is resistant to treatment.


Cutaneous lymphoma

description: A lymphoma involving the skin.


Seminoma, anaplastic

description: A seminoma of the testis characterized by increased cellular pleomorphism, high mitotic activity, and a non-prominent stromal lymphocytic infiltrate.


NK-lymphoblastic leukemia/lymphoma

description: A precursor lymphoid neoplasm that expresses CD56 and immature T-cell markers, lacks B-lymphoid and myeloid markers, and has immunoglobulin and T-cell receptor genes in the germline configuration.


Cervical Cancer by AJCC v6 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 6th edition.


name: Borderline Ovarian Serous Surface Papillary Tumor

description: A neoplasm of low malignant potential arising from the ovary. It is characterized by the presence of papillary proliferations that contain atypical serous epithelial cells in the outer surface of the ovary.  There is no evidence of stromal invasion.


Classical Low Grade Fibromyxoid Sarcoma

description: A low grade fibromyxoid sarcoma that may have poorly formed collagen rosettes, but lacks prominent, well formed collagen rosettes.


name: Male Non-Neoplastic Reproductive System Disorder

description: A non-neoplastic disorder that affects the male reproductive system. Representative examples include prostatitis, balanitis, and phimosis.


name: Refractory Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase

description: Polycythemia vera, post-polycythemic myelofibrosis phase that is resistant to treatment.


name: Localized Muscle Invasive Bladder Urothelial Carcinoma

description: A bladder urothelial carcinoma that has focally invaded into the bladder muscularis propria.


Progressive Pseudorheumatoid Dysplasia

description: An autosomal recessive condition caused by mutation(s) in the CCN6 gene, encoding cellular communication network factor 6. It is a progressive arthropathy that clinically resembles rheumatoid arthritis but differs in its radiological appearance.


Antepartum Obstetric Thromboembolism

description: Presence of a blood clot in the maternal vascular system which originated from a distant site during the antepartum period.


name: Squamous intraepithelial neoplasia grade 2


name: Good Prognosis Metastatic Gestational Trophoblastic Tumor

description: Metastatic gestational trophoblastic tumor in which risk factors are absent.


Urothelial carcinoma urethra recurrent

description: The reemergence of urethral urothelial carcinoma after a period of remission.


Stage 0 Testicular Cancer AJCC v8

description: Stage 0 includes: pTis, N0, M0, S0. pTis: Testicular cancer with a finding of germ cell neoplasia in situ. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. (AJCC 8th ed.)


name: Localized Childhood Retinoblastoma by Toronto Guidelines v2

description: Intraocular tumor. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Cervical meningomyelocele

description: A congenital abnormality in the cervical region of the spine in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


name: Refractory Monomorphic Post-Transplant Lymphoproliferative Disorder

description: A monomorphic post-transplant lymphoproliferative disorder that does not respond to treatment.


Encephalopathy Related to COVID-19

description: Encephalopathy in a patient with probable or confirmed acute COVID-19.


name: Stage IIA Pancreatic Cancer AJCC v6 and v7

description: Stage IIA includes: T3, N0, M0.  T3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage III includes: IIIA: (T0-2, N1, M0); IIIB: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Non-Neoplastic Hepatobiliary Disorder

description: A non-neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples include hepatitis, cirrhosis, cholangitis, and cholecystitis.


name: Locally Advanced Digestive System Neuroendocrine Tumor G2

description: Digestive system neuroendocrine tumor G2 that has spread from its original site of growth to nearby tissues or lymph nodes.


Induced cataract

description: A cataract that has been produced artificially or by induction, e.g. as a result of device use, medication, trauma, tears, falls, accidental injury, etc.


Stage IA Vulvar Cancer AJCC v7

description: Stage IA includes: T1a, N0, M0. T1a: Tumor confined to the vulva and perineum, 2 cm or less in greatest dimension, and with stromal invasion no greater than 1 mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Metastatic Extrapulmonary Neuroendocrine Carcinoma

description: Extrapulmonary neuroendocrine carcinoma that has spread to another anatomic site.


name: Recurrent Digestive System Neuroendocrine Tumor G1

description: The reemergence of digestive system neuroendocrine tumor G1 after a period of remission.


name: Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8

description: Stage IIB includes: T2, N0, M0. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Esophageal Neuroendocrine Tumor G1

description: A rare, well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. The majority of cases have a polypoid appearance, are small lesions, and found incidentally.


name: Transcription Factor-Associated Monogenic Diabetes

description: Monogenic diabetes caused by inactivating mutation(s) in transcription factors regulating expression of pancreatic beta cell genes.


name: Bradyarrhythmia Related to COVID-19 Requiring Temporary or Permanent Pacing

description: Bradycardia (ventricular rate less than 60 bpm) showing signs of hypoperfusion and that requires temporary or permanent pacemaker intervention in a patient with probable or confirmed acute COVID-19.


name: Vaginal intraepithelial neoplasia grade 2

description: Vaginal intraepithelial neoplasia characterized by the presence of nuclear intraepithelial neoplastic changes in the lower two-thirds of the epithelium and parakeratosis.


Anemia due to Increased Destruction

description: Anemia that results from an increased rate of erythrocyte destruction.


Acute pericarditis

description: Acute inflammation of the pericardium.


Skin squamous cell carcinoma recurrent

description: The reemergence of squamous cell carcinoma of the skin after a period of remission.


name: Platinum-Refractory Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that progresses during platinum therapy or within one month of completing platinum therapy.


Stage IVA Cervical Cancer FIGO 2009

description: Cervical carcinoma with rectal or bladder involvement. (FIGO 2009)


Viral gastroenteritis

description: Gastroenteritis resulting from a viral infection.


name: Human Papillomavirus-Related Malignant Neoplasm

description: A malignant neoplasm associated with the presence of human papillomavirus infection.


Metaplastic carcinoma

description: A general term used to describe carcinomas arising from epithelial cells that have been transformed into another cells type (metaplastic epithelial cells). A representative example is the adenocarcinoma arising in Barrett esophagus. This term is also used to describe carcinomas in which the malignant epithelial cells show differentiation towards another cell type. A representative example of the latter is the metaplastic breast carcinoma in which the malignant glandular cells show squamous, spindle cell, or chondroid/osseous differentiation.


Foveolar-Type Adenoma

description: A rare neoplastic polyp that arises from the stomach.  It is characterized by the presence of foveolar-type epithelium.  It may be seen in patients with familial adenomatous polyposis.


Avascular joint necrosis

description: Death of bone tissue in a joint due to temporary or permanent interruption of blood flow.


Endogenous Infection

description: An infection caused by an infectious agent that is present on or in the host prior to the start of the infection.


Unresectable Malignant Mesothelioma

description: Malignant mesothelioma that is not amenable to surgical resection.


Classic Type Trichilemmoma

description: Trichilemmoma in which there is no evidence of sclerotic stroma formation.


Small Cell Adenocarcinoma

description: An adenocarcinoma composed of small malignant cells.


Non-Congenital Amegakaryocytosis

description: An acquired non-neoplastic disorder characterized by marked reduction or absence of megakaryocytes and thrombocytopenia.


Imperforate Vagina

description: A congenital birth defect characterized by the absence of a normal vaginal opening.


name: Stage IIIC Uterine Corpus Cancer AJCC v7

description: Stage IIIC includes: IIIC1 (T1-T3, N1, M0); IIIC2 (T1-T3, N2, M0). T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  Endocervical glandular involvement only should be considered as Stage I and not as Stage II. T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. N1: Regional lymph node metastasis to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


name: Central Nervous System Erdheim-Chester Disease

description: Erdheim-Chester disease that affects the central nervous system.


Stage I Appendix Carcinoma AJCC v8

description: Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Malignant Vipoma

description: An aggressive neuroendocrine tumor located in the pancreas or small intestine. It is composed of cells containing vasoactive intestinal peptide.  It is associated with watery diarrhea, hypokalemia, and hypochlorhydria or achlorhydria. It displays vascular invasion and metastasizes to other anatomic sites.


Squamoid eccrine ductal carcinoma

description: A variant of ductal eccrine carcinoma with squamoid metaplasia.


name: T Acute Lymphoblastic Leukemia with Recurrent Genetic Abnormalities

description: T-acute lymphoblastic leukemias characterized by the presence of recurring cytogenetic and/or molecular abnormalities.


name: Diffuse Pediatric-Type High Grade Glioma RTK1

description: An aggressive, WHO grade 4 diffuse glioma usually affecting children, adolescents, or young adults. It is characterized by receptor tyrosine kinase type 1 (RTK1) alterations.


Stage IVA Vulvar Cancer AJCC v7

description: Stage IVA includes: (T1/T2, N3, M0); (T3, Any N, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  T3: Vulvar cancer with tumor of any size with extension to any of the following: upper/proximal 2/3 urethra, upper/proximal 2/3 vagina, bladder mucosa, rectal mucosa, or fixed to pelvic bone.  N3: Vulvar cancer with fixed or ulcerated regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Refractory Primary Myelofibrosis

description: Primary myelofibrosis that is resistant to treatment.


Congenital absence of uterus

description: A congenital abnormality characterized by the complete absence of the uterus.


name: Vaso-Occlusive Crisis in Sickle Cell-Hemoglobin C Disease

description: Sickle cell-hemoglobin C disease exacerbated by sudden pain caused by sickled erythrocytes impeding blood flow within a vessel.


name: Dyskeratosis Congenita, Autosomal Dominant 3

description: Dyskeratosis congenita caused by autosomal dominant mutation(s) in the TINF2 gene, encoding TERF1-interacting nuclear factor 2. Mutations in TINF2 may also lead to another phenotype known as Revesz syndrome (Dyskeratosis Congenita, Autosomal Dominant 5).


Refractory Digestive System Carcinoma

description: A carcinoma hat arises from any part of the digestive system and is resistant to treatment.


name: Hematologic Neoplasm with Germline RUNX1 Mutation

description: An autosomal dominant syndrome characterized by abnormalities in platelet number and function and enhanced risk of developing myelodysplastic syndrome/acute myeloid leukemia at a young age. Patients have germline monoallelic mutations in RUNX1 gene. The clinical presentation is variable, even within the same family. Most affected individuals have a mild to moderate bleeding tendency. Platelet counts are normal or mildly reduced, with normal platelet morphology and variable degrees of platelet dysfunction. Distinct families with germline RUNX1 mutations exhibit varying risks of development of myeloid neoplasms with 11-100% (median: 44%) of family members affected. (WHO 2017)


Parietal cell carcinoma

description: An adenocarcinoma of the stomach arising from the parietal cells. It is characterized by the presence of malignant cells with eosinophilic, finely granular cytoplasm.


name: Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Refractory Childhood Central Nervous System Neoplasm

description: A central nervous system neoplasm in childhood that is resistant to treatment.


Pancreatobiliary-type carcinoma

description: An invasive adenocarcinoma that arises from the ampulla of Vater. It is characterized by the presence of malignant cells that resemble the malignant cells of the pancreatic ductal or extrahepatic bile duct carcinomas.


name: Bile Duct Mucinous Cystic Neoplasm, High Grade

description: A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of severe atypia.


hepatoid adenocarcinoma of gallbladder

description: A rare variant of gallbladder adenocarcinoma.  It is characterized by the presence of a malignant glandular epithelial infiltrate that resembles hepatocellular carcinoma.


Crystal-Storing Histiocytosis

description: A condition characterized by histiocytes containing intra-lysosomal accumulation of immunoglobulin light chains. Crystal-storing histiocytosis is often associated with plasma cell dyscrasias and lymphoproliferative disorders.


name: Clinical Stage II Esophageal Adenocarcinoma AJCC v8

description: Stage II includes: IIA: T1, N1, M0; IIB: T2, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Neuroendocrine Carcinoma of Unknown Primary

description: A neuroendocrine carcinoma that has metastasized from an  unknown primary site.


name: Preinvasive Neoplasm of the Ampullary Region

description: A premalignant neoplastic and dysplastic lesion that arises from the ampulla of Vater.  It is characterized by the absence of invasion.  This category includes intestinal-type adenomas, noninvasive papillary neoplasms of pancreatobiliary type, and flat intraepithelial neoplasia.


Anal Canal Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the anal canal. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Stage IA Esophageal Cancer AJCC v7

description: Stage IA includes: For squamous cell carcinoma: T1, N0, M0, G1, GX, Tumor location: Any. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  For adenocarcinoma: T1, N0, M0, G1-2, X. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated. GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


name: Metastatic Digestive System Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from any part of the digestive system and has metastasized to another anatomic site.


undifferentiated carcinoma of appendix

description: A high grade carcinoma arising from the appendix, characterized by the absence of glandular or squamous differentiation.


Childhood Esophageal Carcinoma

description: A rare carcinoma of the esophagus that occurs during childhood.


name: Localized Malignant Supratentorial Neoplasm

description: A malignant supratentorial neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Distal Urethral Carcinoma

description: A carcinoma that arises from the distal part of the urethra.


Tuberculosis of adrenal glands

description: Tuberculosis of the adrenal gland.


name: Testicular Sex Cord-Gonadal Stromal Tumor, Mixed Forms

description: A sex cord-stromal tumor of the testis which may contain any combination of cell types, for example Sertoli cells, Leydig cells, and granulosa cells. Symptoms include testicular swelling and gynecomastia.


name: Lugano Classification Stage II Bulky Adult Lymphoma AJCC v8

description: Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


Schizoaffective disorder, bipolar type

description: Schizoaffective disorder with episodes of mania and depression.


name: Digestive System Large Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from any part of the gastrointestinal system.  It is characterized by the presence of malignant large cells.


name: Clinical Stage IV Cutaneous Melanoma AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Evidence of distant metastasis. (AJCC 8th ed.)


Gastrointestinal Carcinoid Tumor

description: A well differentiated neuroendocrine neoplasm of low grade arising from the digestive system. It is composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with small vesicular nuclei. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. The tumor can occur anywhere in the digestive system; approximately 90% arise in the appendix.


Refractory Esophageal Adenocarcinoma

description: Esophageal adenocarcinoma that is resistant to treatment.


name: Stage II Adult Diffuse Mixed Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Chemical Gastritis

description: Gastritis caused by injury to the gastric mucosa by chemicals. The injury occurs due to reflux of bile and pancreatic enzymes.


name: Diffuse malignant lymphoma - centroblastic-centrocytic


Stage IIB Gastric Cancer AJCC v7

description: Stage IIB includes: (T4a, N0, M0); (T3, N1, M0); (T2, N2, M0); (T1, N3, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


name: Childhood Ependymoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood ependymoma according to the Toronto childhood cancer staging guidelines v2.


Atrophic arthritis

description: An antiquated term indicating arthritis and bone loss.


Carcinoma in situ of fallopian tube

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (limited to tubal mucosa). N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


name: MITF Pathway-Activated Melanocytic Tumor

description: A cutaneous neoplasm associated with MITF gene rearrangement and either ACTIN-MITF translocation or MITF-CREM translocation. It is composed of large cells with clear cytoplasm that exhibit melanocytic differentiation and proliferate in the dermis. It presents as a single non-pigmented cutaneous nodule.


small cell carcinoma of appendix

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the wall of the appendix. It is characterized by the presence of malignant small cells.


name: Childhood Pre-B Acute Lymphoblastic Leukemia

description: Pre-B acute lymphoblastic leukemia that occurs during childhood.


In situ follicular neoplasia

description: A follicular neoplasia confined to the germinal centers of the lymph nodes, without evidence of disseminated disease. It is characterized by the replacement of a germinal center by neoplastic centrocytes with uniformly intense positivity for BCL2. The surrounding mantle cuff and lymphoid architecture are intact. It has a low rate of progression to follicular lymphoma, but is often associated with prior or synchronous overt lymphoma.


Benign Familial Infantile Seizures

description: A genetically heterogenous afebrile seizure disorder of infancy, typically occurring between the third and eight month of life, that is characterized by brief partial seizures occurring in clusters over a day or several days. Psychomotor and neurologic development before and after seizures are normal.


name: Refractory Anal Canal Squamous Cell Carcinoma

description: Anal canal squamous cell carcinoma that is resistant to treatment.


Chronic candidiasis

description: Candidiasis that is persistent or long-standing in nature.


Clear cell adenocarcinoma of lung

description: A well differentiated morphologic variant of lung adenocarcinoma characterized by the predominance of clear cells.


name: Benign Germinative Follicular Epithelium Neoplasm

description: A neoplasm that arises from the germinative follicular epithelium and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Benign neoplasm of extrahepatic bile ducts

description: A neoplasm that arises from the extrahepatic bile ducts and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Resectable Oligodendroglioma

description: An oligodendroglioma that is amenable to surgical resection.


name: Localized Gastroesophageal Junction Adenocarcinoma

description: An adenocarcinoma that arises from the gastroesophageal junction and has not spread to other anatomic sites.


Congenital non-progressive ataxia

description: A clinically and genetically heterogenous group of rare, predominantly non-progressive neurological disorders present at birth and characterized by hypotonia, developmental delays, and ataxia. Cognitive and motor impairments may improve over time.


Cervical Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the cervix. Representative examples include endometriosis and cervicitis.


name: Malignant Lymphoma, Non-Cleaved Cell Type


Stage II Vulvar Cancer AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Carcinoma Arising in Bladder Diverticulum

description: A carcinoma arising in a bladder diverticulum. Approximately one-third to half of the cases represent non-invasive, low-grade or high-grade urothelial carcinomas. Approximately half of the invasive carcinomas are urothelial. The rest include adenocarcinomas, squamous cell carcinomas, and small cell carcinomas.


Grade 1 Diffuse Follicular Lymphoma

description: A follicular lymphoma with diffuse pattern characterized by the presence of 5 or less centroblasts per 40 high-power fields.


name: Stage IV Low Grade Adult Non-Hodgkin's Lymphoma


Unresectable Osteosarcoma

description: An osteosarcoma which is not amenable to surgical resection.


Giant cell and spindle cell carcinoma

description: A malignant epithelial neoplasm composed of giant, pleomorphic cells and spindle cells.


name: Gallbladder Benign Non-Epithelial Neoplasm

description: A non-epithelial neoplasm that arises from the gallbladder and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include leiomyoma, lipoma, and neurofibroma.


name: Borderline Fallopian Tube Endometrioid Tumor

description: A neoplasm of low malignant potential arising from the fallopian tube. It is characterized by the presence of glandular or cystic spaces which contain atypical glandular epithelial cells resembling endometrial cells.  There is no evidence of stromal invasion.


name: Non-T Non-B CALLA Positive Adult Acute Lymphoblastic Leukemia

description: A non-T, non-B, acute lymphoblastic leukemia in which the lymphoblasts are positive for the common acute lymphoblastic leukemia antigen (CALLA) occurring in adults.


name: Pathologic Stage IIA Merkel Cell Carcinoma AJCC v8

description: Stage IIA includes: T2-3, N0, M0. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Non-Neoplastic Corneal Disorder

description: A non-neoplastic disorder that affects the cornea.