name: Stage IIIC Uterine Corpus Cancer AJCC v8

description: Stage IIIC includes: IIIC1: T1-T3, N1/N1mi/N1a, M0; IIIC2: T1-T3, N2/N2mi/N2a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N1: Regional lymph node metastasis to pelvic lymph nodes. N1mi: Regional lymph node metastasis (greater than 0.2 mm but nor greater than 2.0 mm in diameter) to pelvic lymph nodes. N1a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2mi: Regional lymph node metastasis (greater than 0.2 mm but not greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Thrombotic microangiopathy that presents in some patients undergoing hematopoietic stem cell transplantation (HSCT). Though similar in presentation to thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS), transplant-associated thrombotic microangiopathy (TA-TMA) is a distinct disorder. Several risk factors may be associated with TA-TMA, including high-dose chemotherapy, radiation therapy, HLA mismatch, use of calcineurin inhibitors, acute graft-versus-host disease (GVHD), and infections.


Corneal dellen

description: Corneal thinning just anterior to the limbus secondary to abnormal and/or irregular bulbar conjunctival contour.


Spindle cell melanoma, type B

description: A melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli. Representative example is the type B spindle cell uveal melanoma.


name: Esophageal Adenocarcinoma by AJCC v8 Stage

description: A term that refers to the staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Naevus Lipomatosus Superficialis

description: A rare developmental anomaly characterized by the presence of ectopic adipose tissue within the upper half of the dermis. (WHO 2018)


name: asymptomatic carrier of alpha-thalassemia

description: A condition in which a person has reduced protein production from one of the four alpha-globin alleles.


Stage IIIC Cervical Cancer FIGO 2018

description: Cervical carcinoma with involvement of pelvic and/or para-aortic lymph nodes, irrespective of tumor size and extent (with r and p notations). (FIGO 2018)


Recurrent Severe Aplastic Anemia

description: The reemergence of severe aplastic anemia after a period of remission.


name: Recurrent Pancreatic Neuroendocrine Carcinoma

description: The reemergence of pancreatic neuroendocrine carcinoma after a period of remission.


Stage II Cervical Cancer FIGO 2018

description: The cervical carcinoma invades beyond the uterus, but has not extended onto the lower third of the vagina or to the pelvic wall. (FIGO 2018)


Low Grade Osteosarcoma

description: An osteosarcoma with low-grade morphological features. This category includes parosteal osteosarcoma and low-grade central osteosarcoma.


Obstructed femoral hernia

description: The protrusion of contents of the abdominal cavity, into the femoral canal, which results in obstruction of intestinal peristalsis.


description: Tuberculosis disease that is caused by a pre-extensively drug-resistant strain of Mycobacterium tuberculosis.


Non-Neoplastic Pancreatic Disorder

description: A non-neoplastic disorder that affects the pancreas. Representative examples include pancreatitis and pancreatic insufficiency.


name: Platelet Disorder, Familial, with Associated Myeloid Malignancy

description: An autosomal dominant condition caused by mutation(s) in the RUNX1 gene, encoding runt-related transcription factor 1. It is characterized by thrombocytopenia, abnormal platelet function, and a propensity to develop acute myeloid leukemia.


Sporadic Gastric Diffuse Adenocarcinoma

description: A sporadic adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of poorly cohesive malignant cells and absence of glandular formations.


Cesarean Scar Pregnancy

description: An ectopic pregnancy implanted in a previous cesarean (hysterotomy) scar, surrounded by myometrium and connective tissue.


Geleophysic Dysplasia 1

description: An autosomal recessive condition caused by mutation(s) in the ADAMTSL2 gene, encoding ADAMTS-like protein 2. It is characterized by severe short stature, short hands and feet, skin thickening, and variable cardiorespiratory abnormalities.


Kir6.2-Associated Diabetes Mellitus

description: Diabetes mellitus caused by activating mutation(s) in the KCNJ11 gene, encoding the inwardly rectifying Kir6.2 subunit of the pancreatic beta cell adenosine triphosphate-sensitive potassium channel. Note: Inactivating mutation(s) in the KCNJ11 gene result in hyperinsulinism.


Congenital neuropathy

description: Neuropathy, the cause of which is present at birth.


Recurrent Ureter Carcinoma

description: The reemergence of ureter carcinoma after a period of remission


Cystitis Cystica and Glandularis

description: A reactive inflammatory disorder affecting the bladder.  It is characterized by the development of small cysts in the bladder wall.  The cysts are lined by urothelial cells and metaplastic glandular cells.


Non-Neoplastic Gallbladder Disorder

description: A non-neoplastic disorder that affects the gallbladder. Representative examples include cholecystitis and adenomyomatosis.


name: Stage III Low Grade Adult Non-Hodgkin's Lymphoma


True Thymic Hyperplasia

description: An increase in gross volume and weight of the thymus gland, with maintenance of normal lobular architecture, and preservation of corticomedullary differentiation.


name: Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type

description: An X-linked recessive condition caused by mutation(s) in the UBE2A gene, encoding ubiquitin-conjugating enzyme E2 A. It is characterized by facial dysmorphisms and intellectual impairment.


name: Malignant Peripheral Nerve Sheath Tumor with Mesenchymal Differentiation

description: A malignant peripheral nerve sheath tumor characterized by the presence of mesenchymal differentiation.  Representative example is the malignant Triton tumor which contains a rhabdomyosarcomatous component.


name: Non-Inflammatory Female Reproductive System Disorder

description: A non-inflammatory disorder that affects the female reproductive system.


Bisphosphonate-associated osteonecrosis

description: Necrosis of the mandible or maxilla in patients receiving intravenous or oral bisphosphonate therapy.  It usually manifests with slow healing or failure to heal of a jaw bone following oral surgery.  In a minority of cases, the necrosis appears spontaneously.  Signs and symptoms include pain, swelling and infection of the affected area.


Benign Extragonadal Germ Cell Tumor

description: A germ cell tumor that arises from an anatomic site other than the testis or ovary. There is no evidence of atypia or metastases.


name: Unspecified nonpsychotic mental disorder following organic brain damage

description: Any mental disorder that occurs secondary to organic brain damage, and that is not associated with psychosis.


name: Refractory Endometrial Squamous Cell Carcinoma

description: Endometrial transitional cell carcinoma that is resistant to treatment.


name: Kidney Mixed Epithelial and Stromal Tumor Family

description: A family of tumors ranging from predominantly cystic tumors (adult cystic nephromas) to tumors that are variably solid (mixed epithelial and stromal tumors) and contain biphasic epithelial and stromal components with spindle stroma, glands, and cysts. Most of these tumors are benign. (WHO 2016).


description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the skin.


Refractory Pancreatic Adenocarcinoma

description: Pancreatic adenocarcinoma that is resistant to treatment.


name: Nodular Sclerosis Classic Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for nodular sclerosis classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Cervical Meningocele

description: A congenital abnormality in the cervical region of the spine in which the meninges protrude through a defect in the spinal column.


Primary Cold Agglutinin Disease

description: A clonal B-cell lymphoproliferative disease of the bone marrow that results in autoimmune hemolytic anemia. It is distinct from lymphoplasmacytic lymphoma and IgM monoclonal gammopathy of undetermined significance. It lacks MYD88 gene mutation and is associated with trisomies of chromosomes 3, 12, and 18, and mutations in KMT2D and CARD11 genes.


name: Recurrent High Grade Endometrioid Adenocarcinoma

description: The reemergence of high-grade endometrioid adenocarcinoma after a period of remission.


name: Acute Myeloid Leukemia with t(11;17)(q23;q21); ZBTB16-RARA

description: Acute myeloid leukemia with the variant RARA t(11;17)(q23;q21) and the expression of ZBTB16-RARA fusion protein.  It lacks differentiation response to retinoids treatment.


Advanced cancer

description: A malignant neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Dermal Spitz Nevus

description: A Spitz nevus characterized by the presence of an intradermal melanocytic component without junctional melanocytic activity.


Borderline Paratesticular Serous Tumor

description: A rare, non-invasive, serous cystic tumor that arises from the paratesticular structures. It is characterized by the presence of irregular papillary formations with irregular branching. The papillae are lined by atypical columnar epithelial cells with eosinophilic cytoplasm. Mitoses are rare. Metastases have not been reported.


name: Adult Nodular Sclerosis Classical Hodgkin Lymphoma

description: Nodular sclerosis classic Hodgkin lymphoma occurring in adults.


Chronic Myelomonocytic Leukemia-0

description: A chronic myelomonocytic leukemia characterized by the presence of less than 5 percent blasts in the bone marrow and less than 2 percent blasts in the peripheral blood.


name: Diffuse malignant lymphoma - large non-cleaved cell

description: Antiquated term for diffuse non-Hodgkin lymphomas composed of non-cleaved cells.  The vast majority of cases are mature B-cell lymphomas (Burkitts or diffuse large B-cell lymphomas).


Trichoblastic carcinoma

description: A rare biphasic malignant neoplasm with dual differentiation towards the specialized follicular stroma and germinative follicular cells, which can be strikingly atypical. (WHO 2018)


name: Acute Myeloid Leukemia with t(11;19)(q23.3;p13.1); KMT2A-ELL

description: An acute myeloid leukemia associated with t(11;19)(q23.3;p13.1) resulting in KMT2A-ELL gene fusion.


name: Stage IB Pancreatic Cancer AJCC v6 and v7

description: Stage IB includes: T2, N0, M0. T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Acute Myeloid Leukemia with t(10;11)(q21.3;q23.3); TET1-KMT2A

description: An acute myeloid leukemia associated with t(10;11)(q21.3;q23.3) resulting in TET1-KMT2A gene fusion.


Pre-Malignant Skin Epithelial Lesion

description: A term that refers to precancerous epithelial pathologic processes that affect the skin.


name: Reactive lymphoid hyperplasia of lacrimal gland

description: A polyclonal proliferation of lymphoid tissue in the lacrimal gland. It usually presents as painless palpable masses leading to globe displacement, decreased motility, diplopia, and ptosis. It has a tendency to involve bilateral lacrimal glands. There is a higher incidence in females and in the setting of autoimmune disease. (WHO 2018)


Sign or Symptom

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Objective evidence of disease perceptible to the examining practitioner (sign) and subjective evidence of disease perceived by the patient (symptom).


Paraphrenia

description: A form of schizophrenia characterized by delusions (of persecution or grandeur or jealousy); symptoms may include anger and anxiety and aloofness and doubts about gender identity; unlike other types of schizophrenia the patients are usually presentable and (if delusions are not acted on) may function in an apparently normal manner.


name: Asymptomatic human immunodeficiency virus infection

description: An infection caused by human immunodeficiency virus (HIV) that is asymptomatic at the time of testing.


name: 21-hydroxylase deficiency - simple virilizing

description: A classic form of congenital adrenal hyperplasia that is characterized by severe 21-hydroxylase deficiency, resulting in glucocorticoid and mineralocorticoid deficiency, but without clinically significant salt wasting, and with androgen excess, which causes virilization in female infants.


name: PERSISTENT MULLERIAN DUCT SYNDROME, TYPE I

description: Persistent Mullerian duct syndrome due to deficiency of anti-Mullerian hormone.


Recurrent Cervical Adenocarcinoma

description: The reemergence of cervical adenocarcinoma after a period of remission.


Chronic diastolic heart failure

description: Chronic congestive heart failure due to a left ventricle which does not fill properly due to decreased compliance though the ejection fraction may be preserved.


name: Non-Invasive Pancreatic Mucinous-Cystic Neoplasm

description: A cystic epithelial neoplasm that arises from the pancreas and is characterized by the presence of columnar mucin-producing epithelial cells, ovarian-type stroma formation, and the absence of an invasive carcinomatous component.


Refractory Malignant Lymphoid Neoplasm

description: A malignant lymphoid neoplasm that does not respond to treatment.


Splenic thrombosis

description: Formation of a blood clot (thrombus) in the lumen of the splenic vein or splenic artery.


Stage I Osteosarcoma AJCC v7

description: Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Combined BAP1-inactivated melanocytoma

description: A BAP1-inactivated melanocytoma that is combined with a smaller area of melanocytic proliferation in the basal layer of the epidermis.


Acne aggravated

description: A flare of acne which may be precipitated by variety of factors, including hormonal activity, stress, oils and oily cosmetics, sweat, overwashing, and certain foods and drugs.


Malignant glioma of brain

description: A grade 3 or 4 glioma that arises from the brain. This category includes anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligoastrocytoma, anaplastic oligodendroglioma, anaplastic pleomorphic xanthoastrocytoma (all grade 3 gliomas), and glioblastoma (grade 4 glioma).


name: Adenocarcinoma in situ in adenomatous polyp

description: A non-invasive adenocarcinoma arising from the neoplastic glandular cells in an adenomatous polyp.


Pseudoepitheliomatous hyperplasia

description: A benign lesion characterized by epidermal and adnexal epithelial hyperplasia.  It is caused by chronic inflammation and infection.  It may be associated with cutaneous neoplasms as well.


name: Cervical Squamous Intraepithelial Neoplasia 1

description: Cervical squamous intraepithelial neoplasia characterized by the presence of maturation in the upper two-thirds of the squamous epithelium and mild nuclear atypia which is present in all epithelial layers.  Mitotic figures are present in the basal third of the epithelium.


Cerebral Hemangioblastoma

description: A hemangioblastoma that arises from the cerebrum.


name: Hodgkin's disease lymphocyte predominance type stage IV

description: Stage IV adult Hodgkin disease means there is disseminated (multifocal) involvement of one or more extralymphatic organs, with or without associated lymph node involvement, or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ)


Recurrent Intracranial Neoplasm

description: The reemergence of an intracranial neoplasm after a period of remission.


Stage IIIB Cervical Cancer FIGO 2009

description: Cervical carcinoma involving the pelvic sidewall. (FIGO 2009)


Non-Neoplastic Eye Disorder

description: A non-neoplastic disorder that affects the eye.


description: Esophageal adenocarcinoma that has metastasized to a limited number of sites.


name: New Onset Atrial Fibrillation Related to COVID-19

description: Newly occurring atrial fibrillation (AF) in a patient with probable or confirmed acute COVID-19. It is further categorized as first detected AF, paroxysmal AF (self-terminating within seven days of recognized onset), or persistent AF (not self-terminating within seven days).


Blood and lymphatic system disorders

description: A non-neoplastic or neoplastic disorder that affects the hematopoietic and lymphatic system.


Metastatic Cervical Carcinoma

description: A carcinoma of the cervix that has spread to another anatomic site.


name: MYOD1-Mutant Spindle Cell/Sclerosing Rhabdomyosarcoma

description: Spindle cell/sclerosing rhabdomyosarcoma characterized by the presence of MYOD1 p.Leu122Arg substitution mutation. This subtype includes most spindle cell/sclerosing rhabdomyosarcomas in adolescents and young adults, as well as some cases in older adults. It follows an aggressive clinical course.


name: Metastatic Bladder Lipid-Rich Urothelial Carcinoma

description: Bladder lipid-rich urothelial carcinoma that has spread to another anatomic site.


name: Hodgkin's disease nodular sclerosis stage II supradiaphragmatic


Refractory Adnexal Carcinoma

description: Adnexal carcinoma that is resistant to treatment.


name: 46,XX/46,XY Ovotesticular Differences of Sex Development

description: Ovotesticular differences of sex development in individuals with 46,XY/46,XX mosaic karyotype.


Acute Pericarditis Related to COVID-19

description: Acute pericarditis in a patient with probable or confirmed acute COVID-19.


name: Low Grade Esophageal Glandular Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal glandular epithelium.


Cryptococcal gastroenteritis

description: Gastroenteritis resulting from an infection with cryptosporidium.


Unresectable Gastric Carcinoma

description: A gastric carcinoma that is not amenable to surgical resection.


name: Recurrent Fallopian Tube Endometrioid Adenocarcinoma

description: The reemergence of fallopian tube endometrioid adenocarcinoma after a period of remission.


Gnathoschisis

description: A congenital abnormality consisting of clefting in the jaw, which results from incomplete fusion of the embryonic mandibular prominence.


Non-Neoplastic Bone Disorder

description: A non-neoplastic disorder that affects the bone or articular cartilage.


Adult Ganglioneuroma

description: A ganglioneuroma that occurs in adults.


Nonerosive Arthritis

description: An inflammation of one or more joints, without loss of articular cartilage or destruction of subchondral bone.


name: Complete Atrioventricular Septal Defect with Tetralogy of Fallot

description: A rare congenital heart anomaly in which there is coexistence of tetralogy of Fallot and complete atrioventricular septal defect. The latter is characterized by defects in the atrial and ventricular septa and a common atrioventricular valve.


name: Gallbladder Adenocarcinoma, Biliary Type

description: A well or moderately differentiated adenocarcinoma that arises from the gallbladder.  It is the most common type of gallbladder carcinoma and is characterized by the presence of malignant tubular glands.  Intestinal differentiation may be present.


Locally Advanced Unresectable Sarcoma

description: A sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Recurrent Low Grade Glioma

description: The reemergence of low grade glioma after a period of remission.


name: Non-Neoplastic Endocrine Pancreas Disorder

description: A non-neoplastic disorder that affects the endocrine pancreas.


name: Invasive Urothelial Carcinoma with Squamous Differentiation

description: An invasive urothelial carcinoma that exhibits squamous differentiation.


Chronic Lymphoblastic Lymphoma

description: This is an invalid term; lymphoblastic lymphomas are not chronic processes, but counterparts of acute lymphoblastic leukemias.


Lip Infection

description: An acute or chronic infectious process affecting the lips.


name: Endometrioid Adenocarcinoma of the Urinary Tract

description: An exceptionally rare endometrioid adenocarcinoma that arises from the urinary tract. It occurs in middle-aged and elderly females. It is associated with genitourinary endometriosis and has been described in the bladder and ureter.


Brain Development Abnormality

description: A group of congenital or acquired disorders that affect the normal development of the brain.


name: Invasive Micropapillary Urothelial Carcinoma

description: Invasive urothelial carcinoma exhibiting micropapillary growth pattern.


Allergic arthritis

description: Arthritis occurring after the ingestion of allergenic substance(s).


Congenital deformity of hip joint

description: Any anatomic abnormality of the hip that is present at the time of birth.


name: Severe Gastrointestinal Tract Acute Graft Versus Host Disease

description: Graft versus host disease occurring in the gastrointestinal tract and is characterized by complications that may be life-threatening.


name: Pathologic Stage I Retinoblastoma AJCC v8

description: Stage I includes: pT1, pT2, pT3, pN0, cM0, Any H. pT1: Intraocular tumor(s) without any local invasion, focal choroidal invasion, or pre-or intralaminar involvement of the optic nerve head. pT2: Intraocular tumor(s) with local invasion. pT3: Intraocular tumor(s) with significant local invasion. pN0: No lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


name: Lacrimal Drainage System Non-Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma of the lacrimal drainage system characterized by a plexiform or ribbon-like growth pattern, cytological atypia, and lack of histological evidence of keratinization.


Refractory Urinary System Carcinoma

description: Urinary system carcinoma that does not respond to treatment.


name: Recurrent Malignant Male Reproductive System Neoplasm

description: The reemergence of a malignant male reproductive system neoplasm after a period of remission.


name: Invasive Bladder Urothelial Carcinoma with Squamous Differentiation

description: An invasive urothelial carcinoma of the bladder that exhibits squamous differentiation.


name: Mixed Phenotype Acute Leukemia, T/Megakaryocytic

description: A very rare mixed phenotype acute leukemia in which the blasts show evidence of T-cell and megakaryocytic lineage but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation.


Conjunctival Melanoma In Situ

description: A term that refers to conjunctival melanocytic intraepithelial lesions with severe atypia involving close to full thickness of the epithelium or lesions with histologic characteristics of melanoma that lack documented evidence of subepithelial invasion.


Clinical Stage I Retinoblastoma AJCC v8

description: Stage I includes: cT1, cT2, cT3, cN0, cM0, Any H. cT1: Intraretinal tumor(s) with subretinal fluid 5 mm or less from the base of any tumor. cT2: Intraocular tumor(s) with retinal detachment, vitreous seeding, or subretinal seeding. cT3: Advanced intraocular tumor(s). cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Papillary serous cystadenoma

description: A serous benign or low malignant potential cystic epithelial neoplasm characterized by the presence of glandular epithelial cells forming papillary structures.


name: Steroid Resistant Acute Graft Versus Host Disease

description: Acute graft versus host disease that is resistant to treatment with steroids.


name: Fallopian Tube Metaplastic Papillary Tumor

description: A rare metaplastic lesion that arises from the fallopian tube. It is characterized by the presence of an intraluminal papillary proliferation composed of atypical epithelial cells with abundant eosinophilic cytoplasm. In the vast majority of cases, it is an incidental finding during microscopic examination of a fallopian tube in the postpartum period.


Malignant Solid Neoplasm

description: A malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include carcinomas and sarcomas. Hematopoietic and lymphoid tissue malignancies are not considered solid neoplasms.


Recurrent Fallopian Tube Carcinoma

description: The reemergence of fallopian tube carcinoma after a period of remission.


Premalignant Neoplasm

description: A neoplasm that is composed of dysplastic cells and there is no morphologic evidence of infiltration of the surrounding tissues.


name: Non-Neoplastic Disorder by Special Category


ROSE Cluster 1

description: Gene expression cluster 1 as determined by Recognition of Outliers by Sampling Ends (ROSE) in high-risk B-precursor acute lymphoblastic leukemia.


Recurrent Nervous System Neoplasm

description: The reemergence of a nervous system neoplasm after a period of remission.


Astler-Coller C1 Colon Carcinoma

description: Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


name: Refractory T-Cell Large Granular Lymphocyte Leukemia

description: T-cell large granular lymphocyte leukemia that is resistant to treatment.


Hereditary Malignant Neoplasm

description: Malignant neoplasms occurring in families at a rate greater than that expected by chance and caused by germline mutations in a specific gene.


Occlusion of inferior vena cava

description: Blockage of the lumen of the inferior vena cava.


name: Lugano Classification Advanced Stage Adult Lymphoma AJCC v8

description: Advanced stage adult lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


Monogenic Hyperinsulinism

description: A genetically heterogenous group of hyperinsulinemic conditions caused by mutation(s) in one of the many genes involved in the regulation of insulin secretion.


Cervix carcinoma recurrent

description: The reemergence of cervical carcinoma after a period of remission.


Cancer of Urinary Tract

description: A primary or metastatic malignant neoplasm involving the urinary tract.


Ectopic ureter

description: A congenital anomaly in which the ureteral orifice drains into an abnormal location.


Advanced Rare Malignant Solid Neoplasm

description: A rare malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Endometrial Endometrioid Adenocarcinoma with Clear Cell Change

description: A morphologic variant of endometrioid adenocarcinoma characterized by the presence of large multinucleated clear cells.


name: Extended Oligoarticular Juvenile Idiopathic Arthritis

description: Oligoarticular juvenile idiopathic arthritis that eventually involves more than four separate joints.


name: Staphylococcal arthritis and polyarthritis


name: Intellectual Disability, Autosomal Dominant 4

description: An autosomal dominant condition caused by mutation(s) in the CHAMP1 gene, encoding chromosome alignment-maintaining phosphoprotein 1. It is characterized by moderate to severe intellectual disability with poor speech acquisition. Variable dysmorphic features may be present as well.


Neoplasm of lacrimal drainage system

description: A benign or malignant neoplasm that affects the lacrimal drainage system.


Ovarian Infection

description: An infectious process affecting the ovary.


name: Stage II Contiguous Adult Diffuse Mixed Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Invasive Urothelial Carcinoma with Trophoblastic Differentiation

description: An invasive urothelial carcinoma characterized by the presence of trophoblastic differentiation.


Occupational Malignant Neoplasm

description: Malignant neoplasm secondary to occupational exposure to carcinogens.


Neuroendocrine cervical carcinoma

description: A malignant, high grade neuroendocrine neoplasm that arises from the cervix. This category includes small cell and large cell neuroendocrine carcinoma.


Acute Stroke Related to COVID-19

description: The sudden or severe onset of neurological deficit(s) attributable to an acute focal vascular injury of the central nervous system in a patient with probable or confirmed acute COVID-19.


name: Verrucous carcinoma of the oral cavity stage IV


Supratentorial Meningioma

description: A meningioma that affects the supratentorial brain.


Glassy cell carcinoma

description: A malignant epithelial neoplasm composed of atypical cells with glassy cytoplasm.


name: Stage IIC Fallopian Tube Cancer AJCC v6 and v7

description: Stage IIC includes: T2c, N0, M0.  T2c: Pelvic extension with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Low grade appendiceal mucinous neoplasm

description: A well differentiated mucinous neoplasm that arises from the appendix.  It is characterized by slow growth and it is associated with the development of pseudomyxoma peritonei.


Genitourinary System Neoplasm

description: A benign or malignant neoplasm that affects the genitourinary system.


Urethral Cancer by AJCC v8 Stage

description: A term that refers to the staging of urethral cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to urothelial (transitional cell), squamous, and glandular carcinomas of the urethra and to urothelial (transitional cell) carcinomas of the prostate and prostatic urethra. It does not apply to squamous cell carcinomas of the penile foreskin (are staged according to the classification for penis), primary urothelial carcinomas of the bladder with transmural involvement of the prostate (are staged according to the classification for urinary bladder), prostatic adenocarcinomas (are staged according to the classification for prostate), mucosal melanomas of the urethra (no AJCC staging system), lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and sarcomas (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs).  (from AJCC 8th Ed.)


Diffuse Non-Pontine Midline Glioma

description: A diffuse glioma that arises from the midline structures of the central nervous system, other than the pons.


name: Cerebral Venous Thrombosis Related to COVID-19


Perihepatic abscess

description: An abscess that is located in the anatomical space surrounding the liver, but which is outside of the liver capsule itself.


Panniculitis Ossificans

description: A condition characterized by subcutaneous fat necrosis with heterotopic calcification. It often occurs as a result of injury to the area.


name: Recurrent Fallopian Tube Clear Cell Adenocarcinoma

description: The reemergence of fallopian tube clear cell adenocarcinoma after a period of remission.


Astler-Coller B3 Rectal Carcinoma

description: Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.)


name: Vaginal Mucinous Adenocarcinoma, Intestinal-Type

description: A vaginal mucinous adenocarcinoma that resembles a large intestinal adenocarcinoma.


Meningeal Leukemia

description: Infiltration of the meninges by an acute or chronic leukemia.


Locally Advanced Malignant Mesothelioma

description: Malignant mesothelioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Acquired hydrocephalus

description: Hydrocephalus that results from head trauma, brain tumors, intracranial hemorrhage, or meningitis.


name: Recurrent Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: The reemergence of undifferentiated high grade pleomorphic sarcoma of bone in childhood after a period of remission.


name: Refractory Adult Acute Lymphoblastic Leukemia

description: Acute lymphoblastic leukemia that occurs in adulthood and does not respond to treatment.


Pigmented Actinic Keratosis

description: Actinic keratosis characterized by the presence of increased melanin pigmentation in the basal keratinocytes.


name: Metastatic Childhood Retinoblastoma by Toronto Guidelines v2

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage II Extragonadal Non-Seminomatous Germ Cell Tumor


Myxoid pleomorphic liposarcoma

description: An exceptionally rare, aggressive adipocytic neoplasm, typically occurring in children and adolescents. Myxoid pleomorphic liposarcoma shows mixed histological features of conventional myxoid liposarcoma and pleomorphic liposarcoma and lacks the gene fusions and amplifications of myxoid liposarcoma, atypical lipomatous tumor, and dedifferentiated liposarcoma. (WHO 2020)


name: T Acute Lymphoblastic Leukemia with SPI1 Rearrangement

description: T acute lymphoblastic leukemia characterized by the presence of SPI1 gene rearrangement. It has a poor prognosis.


name: Pediatric Non-Congenital Ventricular Tachycardia

description: A disorder characterized by an electrocardiographic finding of three or more consecutive complexes of ventricular origin that was not present at birth in an individual under age 21. The QRS complexes are wide and have an abnormal morphology.


Esophageal carcinoma recurrent

description: An esophageal carcinoma which has reappeared after a period of remission or after presumed treatment.


Stage II Fallopian Tube Cancer

description: Stage II includes: (T2, N0, M0); IIA: (T2a, N0, M0); IIB (T2b, N0, M0); IIC (T2c, N0, M0).  T2: Tumor involves one or both fallopian tubes with pelvic extension.  T2a: Extension and/or metastasis to the uterus and/or ovaries.  T2b: Extension to other pelvic structures.  T2c: Pelvic extension with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IB Cervical Cancer AJCC v6 and v7

description: Stage IB includes: IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Perceptual Distortion

description: An incorrect understanding or interpretation of sensory input.


Metastatic High Grade Sarcoma

description: High-grade sarcoma that has spread from its original site of growth to another anatomic site.


name: benign granular cell tumor of gallbladder

description: A granular cell tumor that arises from the gallbladder and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Aplastic Anemia due to Hepatitis

description: Bone marrow failure defined as pancytopenia, secondary to hepatitis.


Reticulosarcoma of spleen

description: An antiquated term that refers to a non-Hodgkin lymphoma composed of diffuse infiltrates of large, often anaplastic lymphocytes affecting the spleen.


name: immune effector cell-associated neurotoxicity syndrome, grade 4

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 0 or if the ICE scale cannot be performed (for adults and children over 12), or if the Cornell Assessment of Pediatric Delirium (CAPD) scale cannot be performed (for children 12 and under), the inability of the affected individual to be arousable without vigorous or repetitive tactile stimuli, life-threatening prolonged (greater than 5 minutes) seizures, or repetitive clinical or electroencephalographically-detected seizures without ever returning to baseline, deep focal motor weakness, diffuse cerebral edema evident on neuroimaging, decerebrate or decorticate posturing, cranial nerve VI palsy, papilledema or Cushing's triad (bradycardia, hypertension, respiratory depression).


Cervical Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm arising from the cervix.


name: Ancylostomiasis due to Ancylostoma braziliense (disorder)

description: Infection by Ancylostoma braziliense.


Metastatic Cervical Adenocarcinoma

description: A cervical adenocarcinoma that has spread to another anatomic site.


Refractory Cutaneous Melanoma

description: Melanoma of the skin that is resistant to treatment.


Breast Schwannoma

description: A schwannoma that arises from the breast.


Gastrointestinal disorder congenital

description: An abnormality of the digestive system that is present at birth or detected in the neonatal period.


Structural Heart Abnormality

description: An anatomic deformity of the heart, ventricles or great vessels.


Retinal arteriovenous malformation

description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the retina.


name: Refractory Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that is resistant to treatment.


Recurrent EBV-Related Lymphoma

description: The reemergence of EBV-related lymphoma after a period of remission.


Paratesticular Adenomatoid Tumor

description: An adenomatoid tumor arising from the paratesticular structures. It is the most common tumor of the paratesticular region. The tail of the epididymis is the most common site of involvement.


Pancreatic adenocarcinoma metastatic

description: An adenocarcinoma that arises from the exocrine pancreatic tissue and has metastasized to other anatomic sites.


description: A lymphoproliferative disorder that develops in an individual with HIV infection.


name: Glioneuronal Tumor with Neuropil-Like Islands

description: A rare, WHO grade II or III infiltrating astrocytoma characterized by the presence of sharply demarcated foci, composed of a neuropil-like matrix.


Stage IIIC Esophageal Cancer AJCC v7

description: Stage IIIC includes: For squamous cell carcinoma: (T4a, N1-2, M0, Any G, Tumor location: Any); (T4b, Any N, M0, Any G, Tumor location: Any); (Any T, N3, M0, Any G, Tumor location: Any).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Extrahepatic Bile Duct Neuroendocrine Tumor

description: A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts.


Diabetic foetopathy

description: A constellation of features seen in the hyperinsulinemic fetus of a diabetic mother that include macrosomia, postnatal hypoglycemia and polycythemia.


name: Type III Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the common pulmonary vein connects to the portal venous system through the diaphragm.


PIK3R1 Deficiency

description: A deficiency caused by mutation(s) in the PIK3R1 gene, encoding phosphatidylinositol 3-kinase regulatory subunit alpha. It is associated with autosomal recessive agammaglobulinemia 7, immunodeficiency 36 and SHORT (short stature, hyperextensibility of joints or hernia, ocular depression, Rieger anomaly, teething delay) syndrome.


name: Malignant Outer Hair Sheath and Infundibulum Neoplasm

description: A malignant neoplasm that arises from the outer hair sheath and infundibulum.


Stage IIA Bone Sarcoma AJCC v7

description: Stage IIA includes: T1, N0, M0, G3, G4.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Myopathy Secondary to Glycogen Storage Disorder

description: A myopathy that was caused by a primary disorder of glycogen storage.


Lacrimal Gland Oncocytic Adenocarcinoma

description: An adenocarcinoma that arises from the lacrimal gland. It is characterized by the presence of large malignant epithelial cells with abundant granular eosinophilic cytoplasm.


name: Hodgkin's disease of intrapelvic lymph nodes

description: Stage I Hodgkin lymphoma involving the subdiaphragmatic region.


name: T Acute Lymphoblastic Leukemia, HOXA Dysregulated

description: T acute lymphoblastic leukemia characterized by an ectopic activation of the HOXA genes.


Vulvar Yolk Sac Tumor

description: A rare yolk sac tumor that arises from the vulva.


Bone marrow mastocytosis

description: A variant of indolent systemic mastocytosis that affects predominantly older males. It is characterized by a limited degree of bone marrow infiltration by clonal mast cells and an absence of skin involvement. The serum tryptase levels are normal or slightly elevated.


Radiation retinopathy

description: Injury of the retina following exposure to radiation.  The retinal injury results from occlusive microangiopathy caused by endothelial cell loss.


Stage 0 Vulvar Cancer

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (preinvasive carcinoma). N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Fibroblastic reticular cell neoplasm

description: A very rare dendritic cell sarcoma affecting the lymph nodes, spleen, and soft tissues. Morphologically it is similar to the interdigitating dendritic cell sarcoma or follicular dendritic cell sarcoma. The tumor cells are positive for cytokeratin and CD68.


Bacterial Toxemia

description: The condition resulting from the spread of bacterial products (toxins) by the bloodstream.


Slipped extraocular muscle

description: Weakness of extraocular muscle function as a result of inadequate securing of the muscle to the sclera during strabismus surgery.


name: Stage IIIA1 Fallopian Tube Cancer AJCC v8

description: Stage IIIA1 includes: T1/2, N1, M0. T1: T1: Fallopian tube cancer with tumor limited to fallopian tube(s). T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Adult Acute Myelomonocytic Leukemia

description: An acute myelomonocytic leukemia occurring in adults.


Locally Recurrent Merkel Cell Carcinoma

description: The reemergence of Merkel cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Refractory WHO Grade 4 Glioma

description: A WHO grade 4 glioma that is resistant to treatment.


name: Clinical Stage IIA Cutaneous Melanoma AJCC v8

description: Stage IIA includes: (T2b, N0, M0); (T3a, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Childhood Digestive System Neuroendocrine Tumor

description: A neuroendocrine tumor that arises from the digestive system and occurs during childhood.


name: Deletion of Chromosome 3p Associated Meningioma

description: A meningioma that is associated with deletion of chromosomal arm 3p.


name: Metastatic Peritoneal Malignant Mesothelioma

description: Peritoneal malignant mesothelioma that has spread from its original site of growth to another anatomic site.


name: Prostate Acinar Pseudohyperplastic Adenocarcinoma

description: Acinar prostate adenocarcinoma characterized by the presence of neoplastic large glands that resemble the benign, non-neoplastic prostate glands.


Other Finding

description: An additional finding not previously noted.


description: Malignant neoplasm occurring in immunodeficient patients.


Renal granular cell carcinoma

description: A renal cell carcinoma with eosinophilic cytoplasm and high nuclear grade.  Granular cells can be seen in any subtype of renal cell carcinoma, including conventional clear cell carcinoma.  This term does not represent a specific subtype of renal cell carcinoma and should no longer be used.


name: Malignant Peripheral Nerve Sheath Tumor of the Skin

description: A malignant peripheral nerve sheath tumor that arises from the skin.


Coronary Venous Dissection

description: A tear within the wall of a coronary vein. (ACC)


name: Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin


Stage IVA Vulvar Cancer AJCC v8

description: Stage IVA includes: (T1-T2, N3, M0); (T3, Any N, M0). T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). T3: Tumor of any size with extension to any of the following: upper/proximal two-thirds of the urethra, upper/proximal two-thirds of the vagina, bladder mucosa, or rectal mucosa; or fixed to pelvic bone. N3: Fixed or ulcerated regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Chondromesenchymal hamartoma of chest wall

description: A rare benign lesion that arises from the rib cage and affects infants.  It results in the formation of a mass which is composed of spindle cells, cartilage, and hemorrhagic cysts.  Surgical resection is usually curative.


name: Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

description: A group of acute myeloid leukemias characterized by recurrent genetic abnormalities, mainly balanced translocations.  (WHO, 2001)


Immunoglobulin deposition disease

description: A mature B-cell neoplasm characterized by the deposition of immunoglobulin in tissues, resulting in impaired organ function. It includes the following entities: primary amyloidosis, heavy chain deposition disease, and light chain deposition disease.


name: Disorder of eye due to diabetes mellitus

description: A group of disorders affecting the eye in patients with diabetes mellitus. It includes cataract, glaucoma, retinopathy, and blindness.


Testicular Cancer by AJCC v8 Stage

description: A term that refers to the staging of testicular cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to postpubertal germ cell tumors of the testis and malignant sex cord-stromal tumors of the testis. It does not apply to spermatocytic tumors (no AJCC staging system), nonmalignant sex cord-/gonadal -stromal tumors (no AJCC staging system), prepubertal germ cell tumors (no AJCC staging system), hematolymphoid tumors (hematologic malignancies staging system), and paratesticular neoplasms (no AJCC staging system).  (from AJCC 8th Ed.)


Refractory Appendix Adenocarcinoma

description: Appendix adenocarcinoma that is resistant to treatment.


Second Primary Cancers

description: A primary malignant neoplasm in a patient who has been already diagnosed with a primary malignant neoplasm in another anatomic site.


name: Solar Radiation-Related Cutaneous Melanoma

description: Cutaneous melanoma that arises following exposure to solar radiation.


Stage II Vulva Cancer AJCC v6

description: Stage II includes: T2, N0, M0.  T2: Tumor confined to the vulva or vulva and perineum, more than 2cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.)


Thrombocytopenia 5

description: An autosomal dominant disorder characterized by decreased platelets, bleeding tendency, and mutation in the ETV6 gene. It is associated with an increased risk of developing hematologic malignancy.


Stage IVA Cervical Cancer AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Tumor invading the mucosa of the bladder or rectum, and/or extending beyond the true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (from AJCC 8th Ed.)


name: Prolonged depressive adjustment reaction

description: Temporary but prolonged and maladaptive depressive signs and symptoms associated with a life event.


Recurrent Paraganglioma

description: The reemergence of paraganglioma after a period of remission.


Microabscess

description: A very small, tiny abscess.


name: Moderately Differentiated Prostate Adenocarcinoma

description: An invasive prostate adenocarcinoma characterized by the presence of malignant cells exhibiting moderate differentiation.


Acute pulmonary embolism

description: An acute embolism to the pulmonary vasculature.


Very Severe Aplastic Anemia

description: Aplastic anemia that is characterized by bone marrow (BM) cellularity less than 25% (or less than 50% if BM is comprised of less than 30% hematopoietic cells), and two or more of the following: absolute neutrophil count of less than 200 per microliter; platelet count of less than 20,000 per microliter; or an absolute reticulocyte count of less than 20,000 per microliter.


Rhizomelic dysplasia

description: A form of skeletal dysplasia characterized by shortening of the bones of the proximal segments of the limbs (i.e. the humeri and femora).


Cerebrovascular Insufficiency

description: A condition resulting in inadequate blood flow through the blood vessels supplying the brain, due to intrinsic disease of the vasculature.


name: Angiotensin converting enzyme inhibitor foetopathy

description: Fetal embryopathy associated with maternal angiotensis converting enzyme (ACE) inhibitor use during pregnancy that may include fetal acute renal failure, growth restriction, oligohydramnios, calvaria abnormalities, preterm birth, and pulmonary hypoplasia with respiratory distress.


Appendix Neuroendocrine Tumor G3

description: A neuroendocrine tumor grade 3 that arises from the appendix.


Leukemia recurrent

description: The reemergence of leukemia after a period of remission.


Metastatic Non-Cutaneous Melanoma

description: A non-cutaneous melanoma that has spread from its original site of growth to another anatomic site.


Childhood Large Cell Lymphoma

description: A large cell lymphoma occurring in childhood.


Refractory Esophageal Carcinoma

description: Esophageal carcinoma that is resistant to treatment.


name: Non-Neoplastic, Non-Molar Gestational Trophoblastic Disorder

description: A category of non-neoplastic gestational trophoblastic disorders that includes the exaggerated placental site reaction and placental site nodule or plaque. It does not include hydatidiform mole.


Conjunctival Carcinoma

description: A carcinoma that arises from the conjunctiva.


Esophageal Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Placental aromatase deficiency

description: An autosomal recessive condition that results in aromatase deficiency in the placenta, causing temporary virilization of the pregnant woman and virilization of her 46,XX fetus.


name: Invasive Large Nested Urothelial Carcinoma

description: A rare invasive urothelial carcinoma characterized by the presence of medium to large nests of malignant cells.


Refractory Malignant Germ Cell Tumor

description: Malignant germ cell tumor resistant to treatment.


Refractory Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that does not respond to treatment.


Non-Neoplastic Breast Disorder

description: A non-neoplastic disorder that affects the breast. Representative examples include fibrocystic disease, gynecomastia, mastitis, and adenosis.


High Grade Intraepithelial Neoplasia

description: A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as grade II (moderate dysplasia) or grade III (severe dysplasia).


name: Transient myocardial ischemia of newborn

description: A condition characterized by a temporary imbalance between the oxygen supply and demand of the heart muscle in the newborn.


Refractory Adenovirus Infection

description: An adenovirus infection that does not respond to treatment.


name: Unresectable Renal Pelvis and Ureter Urothelial Carcinoma

description: Renal pelvis and ureter urothelial carcinoma that is not amenable to surgical resection.


Refractory Acute Lymphoblastic Leukemia

description: Acute lymphoblastic leukemia that does not respond to treatment.


name: Human Papillomavirus-Independent Cervical Adenocarcinoma In Situ

description: Cervical adenocarcinoma in situ not associated with human papillomavirus infection.


name: Hematologic Neoplasm with Germline ANKRD26 Mutation

description: An autosomal dominant disorder characterized by moderate thrombocytopenia and increased risk of developing myelodysplastic syndrome/acute myeloid leukemia. This disorder is characterized by germline mutations in ANKRD26, located on chromosome band 10p12.1. (WHO 2017)


Early Unfavorable Hodgkin Lymphoma

description: An early Hodgkin lymphoma with unfavorable prognosis.


Stage IIB Appendix Carcinoma AJCC v7

description: Stage IIB includes: T4a, N0, M0. T4a: Tumor penetrates visceral peritoneum including mucinous peritoneal tumor within the right lower quadrant.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Childhood TdT Positive Acute Lymphoblastic Leukemia

description: TdT positive acute lymphoblastic leukemia that occurs during childhood.


Fetus in fetu

description: An exceptionally rare congenital abnormality in which a malformed and parasitic fetus is located within the body of its twin.


name: Endometrioid adenocarcinoma, ciliated cell variant

description: An endometrioid adenocarcinoma arising from the endometrium, in which ciliated cells line the majority of the malignant glands.


Adult Acute Myeloblastic Leukemia

description: An acute myeloid leukemia occurring in adults.


name: Infection and inflammatory reaction due to internal orthopedic fixation device

description: An infectious process involving an implanted medical device and the surrounding tissues.


Nonorganic Insomnia

description: Insomnia as a result of an extrinsic cause.


name: EBV-Related Lymphoproliferative Disease with Primary Immunodeficiency

description: An EBV-related lymphoid proliferation that arises in the setting of immune deficiency due to a primary immunodeficiency or immunoregulatory disorder.


name: Low Grade Anal Canal Intraepithelial Neoplasia

description: Intraepithelial neoplasia involving the anal canal.  The epithelial cells exhibit mild dysplasia (grade I intraepithelial neoplasia).


name: Gallbladder Mucinous Cystic Neoplasm with Intermediate Grade Intraepithelial Neoplasia

description: A non-invasive mucinous cystic neoplasm that arises from the gallbladder epithelium.  It is characterized by the presence of moderate atypia.


Osteosarcoma recurrent

description: The reemergence of osteosarcoma after a period of remission.


name: Acute Myeloid Leukemia with In-Frame bZIP CEBPA Mutation

description: An acute myeloid leukemia characterized by the presence of CEBPA bZIP domain mutation. It is associated with a favorable clinical outcome.


name: Stage II Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

description: Stage II includes: T2, N0, M0. T2: Pheochromocytoma measuring 5 cm or more in greatest dimension or paraganglioma-sympathetic of any size, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Antenatal Hydronephrosis

description: Hydronephrosis that occurs in a fetus.


name: Stage IV Adult Diffuse Small Cleaved Cell Lymphoma

description: Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)


Malignant Proliferating Pilar Tumor

description: A rare malignant neoplasm that arises from the outer root sheath of the hair follicle. It usually occurs in the scalp, face and trunk. Histopathology shows cords of malignant squamous cells infiltrating into the dermis.


Stage IB Bone Cancer AJCC v7

description: Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


name: Hodgkin's Disease, Nodular Sclerosis, Lymphocyte Depletion


name: Platinum-Resistant Malignant Germ Cell Tumor

description: A malignant germ cell tumor that is resistant to platinum therapy.


name: Adult Unfavorable Prognosis Hodgkin Lymphoma

description: A Hodgkin lymphoma with unfavorable prognosis that occurs during adulthood.


Mycotic pericarditis

description: Pericarditis that is caused by an infection with a fungal agent.


name: Metastatic malignant neoplasm to conjunctiva

description: A malignant neoplasm that has spread to the conjunctiva from another anatomic site.


name: Anaplastic (Malignant) Intracranial Meningioma

description: An anaplastic meningioma that arises within the cranial cavity.


name: Hereditary factor XII deficiency disease

description: A rare autosomal recessive inherited bleeding disorder caused by deficiency of coagulation factor XII. It may be asymptomatic or manifest with bleeding.


Metastatic Vaginal Carcinoma

description: A carcinoma that arises from the vagina and has metastasized to another anatomic site.


name: Osteoclastic Giant Cell-Rich Tumor of Bone

description: A benign, intermediate, or malignant bone tumor characterized by the presence of osteoclast-like giant cells. Clinical presentation includes pain, edema, and decreased range of motion in the affected joint.


Metastatic endometrioid carcinoma

description: An endometrioid adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IVA includes: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Recurrent Malignant Neoplasm of Multiple Primary Sites

description: Reemergence of a malignant neoplasm of multiple primary sites after a period of remission.


Thalassemic Osteopathy

description: Bone disorders that present in thalassemia patients.


name: Breast Fibrocystic Change, Proliferative Type without Atypia

description: Breast fibrocystic change characterized by the presence of epithelial cell hyperplasia.  There is no evidence of epithelial atypia.


Cervical Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm that arises from the cervix.


Granular Cell Astrocytoma

description: An astrocytoma characterized by the presence of large numbers of neoplastic cells with granular, PAS-positive cytoplasm. It is associated with an aggressive clinical course, even when the histologic features suggest a lower-grade astrocytoma.


name: High Grade Conjunctival Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process with high-grade dysplastic features involving the conjunctival epithelium.


name: Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage II includes: IIA: T1, N1, M0; IIB: T2, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Nuclear Cataract Grade 2

description: A stage of nuclear sclerotic cataract marked by moderate yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Retinoblastoma, undifferentiated

description: A retinoblastoma composed of small, undifferentiated cells. It is often associated with necrotic changes.


Malignant tumor, small cell type

description: A malignant neoplasm characterized by the presence of small atypical cells.


Stage IIC Prostate Cancer AJCC v8

description: Stage IIC includes: (T1-2, N0, M0, PSA less than 20, Grade Group 3); (T1-2, N0, M0, PSA less than 20, Grade Group 4). T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


Delusional disorder, somatic type

description: A subtype of delusional disorder characterized by the central delusional theme that the individual has some physical defect or medical condition.


name: T Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

description: T-lymphoblastic leukemia/lymphoma in which further genetic/molecular characterization is not available.


Bladder Paraganglioma

description: An extra-adrenal sympathetic paraganglioma arising from the urinary bladder.  Clinical signs include hypertension and hematuria.


name: Childhood Malignant Genitourinary System Neoplasm

description: A malignant neoplasm that affects the genitourinary system during childhood.


Broad Ligament Serous Adenocarcinoma

description: A rare serous adenocarcinoma that arises from the broad ligament.


name: Malignant Non-Hodgkin Lymphoma, Cleaved Cell


name: Vaginal Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the vagina and is characterized by the presence of keratin pearls. Intercellular bridges and cytoplasmic keratinization are usually present.


Cutaneous neurofibroma

description: A neurofibroma that grows along small branches of nerves in the dermis in patients with neurofibromatosis. It presents as a solid cutaneous tumor.


Esophageal adenocarcinoma recurrent

description: An esophageal adenocarcinoma which has reappeared after a period of remission or after presumed treatment.


Cervical Cancer by AJCC v7 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 7th edition.


Acute Myocardial Injury

description: Acute myocardial injury diagnosed by rise and fall in cardiac troponin above the 99th percentile of a reference population.


Stage IIA1 Cervical Cancer AJCC v9

description: Stage IIA1 includes: T2a1, N0, M0. T2a1: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion measuring 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Conjunctival Spitz Nevus

description: A rare nevus that arises from the conjunctiva. It is characterized by the presence of large spindle-shaped or epithelioid melanocytes.


Prostate Undifferentiated Carcinoma

description: An invasive prostate carcinoma characterized by the presence of undifferentiated malignant cells.


Refractory Liposarcoma

description: Liposarcoma that does not respond to treatment.


Stage IV Cervical Cancer AJCC v6 and v7

description: Stage IV includes: IVA: (T4, Any N, M0); IVB (Any T, Any N, MI). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M1: Distant metastasis. (AJCC 6th and 7th eds.)


Anaplastic Astroblastoma, MN1-Altered

description: An astroblastoma, MN1-altered, characterized by the presence of high mitotic activity, cytologic atypia, and architectural distortion.


Refractory Appendix Carcinoma

description: Appendix carcinoma that is resistant to treatment.


Critical illness myopathy

description: Acute muscle weakness and paralysis that develops in critically ill patients who have been treated with multiple drugs during their intensive care unit stay. It is associated with delayed weaning from mechanical ventilation and prolonged rehabilitation.


name: Lugano Classification Limited Stage Adult Lymphoma AJCC v8

description: Limited stage adult lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


name: Childhood Acute Lymphoblastic Leukemia CNS 2 Toronto Guidelines v2

description: No clinical signs of CNS involvement and blasts in CSF and either: WBC < 5/μL CSF or WBC > or = 5/uL CSF and RBC > or = 10/uL CSF and WBC/RBC in CSF < or = 2x WBC/RBC in blood. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage IIIC Appendix Carcinoma AJCC v8

description: Stage IIIC includes: Any T, N2, M0. N2: Four or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


description: Trigeminal neuralgia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Sensory Disorders

description: An interruption or alteration in the sensory activity or functions of the nervous system.


Metastatic Merkel Cell Carcinoma

description: A Merkel cell carcinoma that has spread from the original site of growth to another anatomic site.


Endometrial Neuroendocrine Carcinoma

description: A small cell or large cell neuroendocrine carcinoma arising from the endometrium.


name: Ampullary Flat Intraepithelial Neoplasia, High Grade

description: A non-polypoid, preinvasive neoplasm that arises from the ampulla of Vater.  It is characterized by the presence of high grade dysplasia.


name: Chronic Ocular Graft Versus Host Disease

description: Chronic graft versus host disease occurring in the eye.


Esophageal Basal Cell Hyperplasia

description: A reactive (non-neoplastic) hyperplastic process affecting the esophageal squamous epithelium that is caused by inflammation.  Morphologically it involves more than 15% of the thickness of the esophageal squamous epithelium.  Its association with an increase risk of developing squamous cell carcinoma remains controversial.


name: Pathologic Stage IIIA Cutaneous Melanoma AJCC v8

description: Stage IIIA includes: T1a/b-T2a, N1a or N2a, M0. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Diffuse Midline Glioma

description: A diffuse glioma that arises from the midline structures of the central nervous system. The majority of these tumors are found in the brainstem.


name: Mendelian susceptibility to mycobacterial disease

description: A rare inherited disorder typically presenting in childhood characterized by a susceptibly to infection (local and disseminated), particularly from mycobacteria. This disorder has been associated with mutations in several genes including: IFNGR1, IFNGR2, STAT1, IL12B, IL12RB1, IRF8,  ISG15, IKBKG, CYBB.


name: Unresectable Gastroesophageal Junction Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the gastroesophageal junction and is not amenable to surgical resection.


name: Adult Acute Myeloid Leukemia without Maturation

description: An acute myeloid leukemia without maturation occurring in adults.


Advanced Angiosarcoma

description: An angiosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Basal Cell Carcinoma

description: Basal cell carcinoma that is not amenable to surgical resection.


anaplastic carcinoma of urethra

description: An undifferentiated carcinoma arising from the urethra.


Conjunctival Blue Nevus

description: A benign melanocytic neoplasm that arises from the conjunctiva. It is characterized by the presence of dendritic and spindle-shaped melanocytes in the subepithelial connective tissue. It presents as a dark brown or black, slightly elevated conjunctival lesion.


Bilateral anophthalmos of eyes

description: A rare congenital abnormality characterized by the complete absence of ocular tissue in both orbits.


name: acute megakaryoblastic leukemia in relapse

description: The reemergence of acute megakaryoblastic leukemia after a period of remission.


name: Childhood Retinoblastoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood retinoblastoma according to the Toronto childhood cancer staging guidelines v2.


Localized Lymphoma

description: A lymphoma that is confined to a specific site without evidence of spread to other anatomic sites.


malignant enteroglucagonoma

description: A glucagon-producing malignant endocrine neoplasm. It displays vascular invasion and metastasizes to other anatomic sites.


name: Advanced Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: Extrapulmonary large cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage III Renal Pelvis and Ureter Cancer AJCC v7

description: Stage III includes: T3, N0, M0. T3: For renal pelvis only: tumor invades beyond muscularis into peripelvic fat or the renal parenchyma.  For ureter only: tumor invades beyond muscularis into periureteric fat.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Anal cancer recurrent

description: The reemergence of anal carcinoma after a period of remission.


Gender identity disorder

description: A disorder characterized by a strong and persistent cross-gender identification (such as stating a desire to be the other sex or frequently passing as the other sex) coupled with persistent discomfort with his or her sex (manifested in adults, for example, as a preoccupation with altering primary and secondary sex characteristics through hormonal manipulation or surgery).


Thoracic Meningocele

description: A congenital abnormality in the thoracic region of the spine in which the meninges protrude through a defect in the spinal column.


name: Unresectable Glioneuronal and Neuronal Tumors

description: Glioneuronal and neuronal tumors that are not amenable to surgical resection.


name: Refractory Endometrial Clear Cell Adenocarcinoma

description: Endometrial clear cell adenocarcinoma that is resistant to treatment.


name: Locally Advanced Extrapulmonary Neuroendocrine Carcinoma

description: Extrapulmonary neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Infant T Acute Lymphoblastic Leukemia

description: A T-acute lymphoblastic leukemia that occurs in infancy.


Metastatic Urethral Carcinoma

description: A urethral carcinoma that has spread to another anatomical site.


name: FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting 6-50% solid non-glandular, non-squamous growth.


name: Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia

description: Acute myeloid leukemias arising as a result of the mutagenic effect of therapeutic agents targeting DNA-topoisomerase II. The vast majority of patients present without a preceding myelodysplastic phase. The acute myeloid leukemias are usually of the monoblastic or myelomonocytic type. Clonal cytogenetic abnormalities are frequently present and usually involve chromosome 11q23 (MLL gene).


Refractory Mucosal Melanoma

description: Mucosal melanoma that is resistant to treatment.


Glucokinase-Associated Hyperinsulinism

description: Hyperinsulinism due to activating mutation(s) in the gene GCK, encoding glucokinase.


Childhood Grade I Meningioma

description: A grade I meningioma that occurs during childhood.


name: Stage 0 Childhood Retinoblastoma by Toronto Guidelines v2

description: The tumor is confined to the globe. Enucleation has not been performed. (The patient is treated "conservatively" with either focal therapies or chemotherapy.) (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Astroblastoma, MN1-Altered

description: An astroblastoma, MN1-altered that occurs during childhood.


Stage IIIA Prostate Cancer AJCC v8

description: Stage IIIA includes: T1-2, N0, M0, PSA 20 or more, Grade Group 1-4; T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


name: Invasive Bladder Conventional Urothelial Carcinoma

description: Invasive bladder urothelial carcinoma characterized by the presence of malignant cells forming trabeculae, cords, sheets, and nests. Individual malignant cells are also present.


FNCLCC Sarcoma Grade 1

description: A sarcoma with a total score of 2 or 3 according to the FNCLCC guidelines.


Refluxing Megaureter

description: A megaureter that demonstrates retrograde urine flow without ureteral obstruction.


Meningothelial Hamartoma

description: A hamartoma characterized by the presence of collections of non-neoplastic arachnoidal cells.


name: Malignant urinary tract neoplasm metastatic

description: The spread of a malignant neoplasm to the urinary tract from an adjacent or distant anatomic site.


transvestism

description: A disorder characterized by recurrent sexual urges, fantasies, or behaviors in a heterosexual male involving cross-dressing.


name: adenocarcinoma of gallbladder with squamous metaplasia

description: An infiltrating adenocarcinoma of the gallbladder characterized by the presence of metaplastic changes of the malignant glandular cells to squamous cells.


Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for Hodgkin lymphomas based on the Ann Arbor classification criteria.


Complicated malaria

description: Acute malaria with signs of organ dysfunction, severe anemia (hemoglobin less than 5 g/dL or hematocrit less than 15%) and/or hyperparasitemia (greater than 5% of red blood cells infected).


name: Papillary transitional cell carcinoma, non-invasive

description: A transitional cell carcinoma characterized by a papillary growth pattern and lack of stromal invasion.


name: Non-Keratinizing Primary Intraosseous Squamous Cell Carcinoma -Solid Type

description: A squamous cell carcinoma that arises centrally from the jaw.  It is characterized by a solid pattern, lack of prominent keratinization, infiltration of the marrow spaces, and osseous resorption.


name: High Grade Prostatic Intraepithelial Neoplasia, Inverted Variant

description: High grade prostatic intraepithelial neoplasia characterized by the presence of secretory cells with their nuclei polarized towards the lumen of the glands.


Non-Neoplastic Conjunctival Disorder

description: A non-neoplastic disorder that affects the conjunctiva.


Unresectable Bladder Carcinoma

description: Bladder carcinoma that is not amenable to surgical resection.


name: Stage I Adult Diffuse Small Cleaved Cell Lymphoma

description: Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


Stage IV Prostate Cancer AJCC v7

description: Stage IV includes: (T4, N0, M0, Any PSA, Any Gleason); (Any T, N1, M0, Any PSA, Any Gleason); (Any T, Any N, M1, Any PSA, Any Gleason). cT4: Tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall.  pT4: Invasion of rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 7th ed.)


name: Diffuse Low Grade Glioma, BRAF p.V600E-Mutant

description: Diffuse low-grade glioma characterized by the presence of BRAF gene mutations encoding a p.V600E substitution mutation.


name: Pathologic Stage IIIB Cutaneous Melanoma AJCC v8

description: Stage IIIB includes: (T0, N1b, N1c, M0); (T1a/b-T2a, N1b/c or N2b, M0); (T2b/T3a, N1a-N2b, M0). T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration.  T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Recurrent Brain Neoplasm

description: The reemergence of a brain neoplasm after a period of remission.


description: A myelodysplastic/myeloproliferative neoplasm that is resistant to treatment.


name: Postoperative Spindle Cell Nodule of the Vagina

description: A rare, benign, non-neoplastic reactive lesion that develops in the vagina at the site of a prior operative procedure. It is composed of spindle cells, small blood vessels, and chronic inflammation.


Radiation-Induced Cancer

description: A malignant neoplasm arising in a site exposed to radiation therapy.


Vulvar Blue Nevus

description: A benign nevus that arises from the vulva and is characterized by the presence of heavily pigmented dendritic melanocytes exclusively in the dermis.


Non-Malignant Neoplasm

description: A category that includes benign neoplasms and neoplasms with uncertain malignant potential. The latter are characterized by clinicopathological features that are not benign, including some degree of mild or mild/moderate atypia/dysplasia, but lack overt malignant morphologic characteristics and there is no evidence of metastasis at the time of diagnosis.


Gonadal Thrombosis

description: Formation of a blood clot (thrombus) in the lumen of the vein that carries blood away from the testis or ovary.


name: Gastric carcinoma stage IV without metastases

description: T4,N2,MO (from PDQ)


Stage IIIB Testicular Cancer AJCC v8

description: Stage IIIB includes: (Any pT/TX, N1-3, M0, S2); (Any pT/TX, Any N, M1a, S2). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. M1a: Testicular cancer with non-retroperitoneal nodal or pulmonary metastases. S2: LDH 1.5-10 x N or hCG (mlU/mL) 5,000-50,000 or AFP (ng/mL) 1,000-10,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Goblet Cell Adenocarcinoma

description: A rare adenocarcinoma that exhibits neuroendocrine differentiation and is associated with the presence of neoplastic signet-ring cells resembling goblet cells of the intestine.


Transplant-Related Carcinoma

description: A carcinoma that arises in a patient with a history of organ transplantation.


Stage IA2 Cervical Cancer AJCC v9

description: Stage IA2 includes: T1a2, N0, M0. T1a2: Tumor with measured stromal invasion of more than 3.0 mm and equal or less than 5.0 mm in depth. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Duodenal fistula

description: An abnormal communication between the duodenum and another organ or cavity.


Stage I Gallbladder Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or muscular layer. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Peritoneal gliomatosis

description: A benign condition characterized by the presence of peritoneal implants composed of mature glial tissue. It is usually accompanied by an ovarian teratoma.


Recurrent Hematologic Malignancy

description: The reemergence of a hematologic malignancy after a period of remission.


Stage II Adult Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Hemoglobin Lepore Syndrome

description: A beta thalassemia resulting from an unequal crossover/recombination event involving portions of the delta and beta globin genes, resulting in underproduction of the abnormal delta-beta globin.


name: Unresectable Pancreatic Neuroendocrine Tumor

description: Pancreatic neuroendocrine tumor that is not amenable to surgical resection.


Lupus Flare

description: An exacerbation of the chronic disease lupus.


Palisaded encapsulated neuroma

description: A benign peripheral nerve sheath tumor characterized by the presence of Schwann cells, axons, and perineurial fibroblasts.  It usually arises from the skin of the head and neck or the oral mucosa.  It presents as a solitary and painless nodular mass.


Refractory Meningioma

description: Meningioma that is resistant to treatment.


Staphylococcal enterocolitis

description: Gastroenteritis resulting from an infection with Staphylococcus aureus.


Advanced Carcinoma

description: Carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage II Cervical Cancer AJCC v9

description: Stage II includes: T2, N0, M0. T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Pathologic Stage IIIC Cutaneous Melanoma AJCC v8

description: Stage IIIC includes: (T0, N2b, N2c, N3b or N3c); (T1a-T3a, N2c or N3a/b/c, M0); (T3b/T4a, Any N greater than or equal to N1, M0); (T4b, N1a-N2c, M0). T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N2c: One clinically occult nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Localized Non-Muscle Invasive Bladder Urothelial Carcinoma

description: A bladder urothelial carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites, and has not invaded the bladder muscularis propria.


Epilepsy aggravated

description: An increase in the duration or intensity of epileptic symptoms in the setting of chronic epilepsy.


name: Epithelioid Hemangioendothelioma with YAP1-TFE3 Gene Fusion

description: Epithelioid hemangioendothelioma characterized by a YAP1-TFE3 gene fusion. This gene fusion occurs in a subset of epithelioid hemangioendotheliomas characterized by the presence of well-formed vessels lined by epithelioid endothelial cells with abundant eosinophilic cytoplasm. Patients with YAP1-TFE3 gene fusion tumors tend to be younger than those with a WWTR1-CAMTA1 gene fusion.


name: Neoantigen-Positive Malignant Solid Neoplasm

description: A malignant solid neoplasm characterized by the expression of antigens resulting from cancer-specific mutations (neoantigens).


name: Lugano Classification Stage IIE Adult Hodgkin Lymphoma AJCC v8

description: Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


name: Femoral Hernia with Obstruction without Mention of Gangrene

description: The protrusion of contents of the abdominal cavity, into the femoral canal, which results in obstruction of intestinal peristalsis, with no mention of necrosis of the herniated contents.


Refractory Ependymoma

description: Ependymoma that does not respond to treatment.


Stage II Osteosarcoma AJCC v7

description: Stage II includes: IIA (T1, N0, M0, G3, G4); IIB (T2, N0, M0, G3, G4).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Metastatic Malignant Neoplasm in the Genitourinary System

description: The spread of a malignant neoplasm to the genitourinary system from an adjacent or distant anatomic site.


Disruptive mood dysregulation disorder

description: A condition in which children or adolescents experience irritability, anger, and intense temper outbursts. The episodes may be frequent and may eventually impact functioning at school, at home or with peers.


Mild Cardiac Valve Regurgitation

description: Evidence of mild retrograde blood flow through the valve(s) of the heart. (ACC)


name: Benign Mixed Epithelial and Mesenchymal Hair Follicle Neoplasm

description: A trichoblastoma characterized by the presence of neoplastic epithelial cells forming cribriform patterns.


Stage IV Vulvar Cancer AJCC v7

description: Stage IV includes: IVA: (T1/T2, N3, M0); (T3, Any N, M0); IVB: (Any T, Any N, M1).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  T3: Vulvar cancer with tumor of any size with extension to any of the following: upper/proximal 2/3 urethra, upper/proximal 2/3 vagina, bladder mucosa, rectal mucosa, or fixed to pelvic bone.  N3: Vulvar cancer with fixed or ulcerated regional lymph node metastasis.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 7th ed.)


name: Stage IV Anal Canal Cancer AJCC v6 and v7

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th and 7th Eds.)


name: Acute Myeloid Leukemia with t(3;8)(q26.2;q24); MYC, MECOM

description: An acute myeloid leukemia associated with t(3;8)(q26.2;q24) resulting in MYC and MECOM rearrangement.


name: Hematologic Neoplasm with Germline Predisposition without a Constitutional Disorder Affecting Multiple Organ Systems

description: Familial hematologic neoplasms associated with germline mutations without a preexisting disorder or organ dysfunction.


Chronic pulmonary aspergillosis

description: A spectrum of disorders associated with long-term Aspergillus infection of the lung that usually occur in immunocompetent individuals with underlying respiratory disorders, and may be characterized by pulmonary fibrosis or cavitation.


name: Advanced Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: Extrapulmonary small cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Unresectable Digestive System Adenocarcinoma

description: An adenocarcinoma that arises from the gastrointestinal system and is not amenable to surgical resection.


Acquired kyphosis

description: Kyphosis, the cause of which is not present at birth.


name: COVID-19-Associated Nervous System Disorder

description: A central or peripheral nervous system disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


name: Coronary Artery Ectasia Related to COVID-19

description: Coronary artery ectasia in a patient with probable or confirmed acute COVID-19.


Childhood Pleomorphic Xanthoastrocytoma

description: A pleomorphic xanthoastrocytoma that occurs during childhood.


name: Congenital abnormality of respiratory system

description: An abnormality of the respiratory system that is present at birth or detected in the neonatal period.