name: ZRANB1 binds APC (Drosophila melanogaster)


name: AXIN is phosphorylated in the destruction complex (Drosophila melanogaster)

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: Phosphorylation of APC component of the destruction complex (Drosophila melanogaster)


name: Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Drosophila melanogaster)


name: Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Drosophila melanogaster)


name: Association of beta-catenin with the destruction complex (Drosophila melanogaster)


name: Degradation of beta-catenin by the destruction complex (Caenorhabditis elegans)

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: Association of beta-catenin with the destruction complex (Caenorhabditis elegans)


name: AXIN is phosphorylated in the destruction complex (Caenorhabditis elegans)


name: Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Caenorhabditis elegans)


name: Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Caenorhabditis elegans)


name: Phosphorylation of APC component of the destruction complex (Caenorhabditis elegans)


name: Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Caenorhabditis elegans)


name: Degradation of ubiquitinated beta catenin by the proteasome (Caenorhabditis elegans)


name: WNT ligand biogenesis and trafficking (Homo sapiens)


name: WLS binds WNT ligands in the Golgi (Homo sapiens)


name: N-linked glycosylation of WNTs (Homo sapiens)


name: WNT ligands traffic to the plasma membrane (Homo sapiens)


name: WLS is endocytosed to the early endosome (Homo sapiens)


name: PORCN palmitoleoylates N-glycosyl WNTs (Homo sapiens)


name: WLS dissociates from retromer (Homo sapiens)


name: WNT ligands traffic to the Golgi (Homo sapiens)


name: WNTs are secreted in exosomes (Homo sapiens)


name: Retromer recycles WLS to the Golgi (Homo sapiens)


name: WLS:WNT complex is internalized for maturation into exosomes (Homo sapiens)


name: Retromer associates with WLS (Homo sapiens)


name: WNT ligand biogenesis and trafficking (Mus musculus)


name: WLS is endocytosed to the early endosome (Mus musculus)


name: WNT ligands traffic to the plasma membrane (Mus musculus)


name: WLS binds WNT ligands in the Golgi (Mus musculus)


name: WLS:WNT complex is internalized for maturation into exosomes (Mus musculus)


name: Retromer associates with WLS (Mus musculus)


name: Retromer recycles WLS to the Golgi (Mus musculus)


name: WNTs are secreted in exosomes (Mus musculus)


name: WNT ligands traffic to the Golgi (Mus musculus)


name: WLS dissociates from retromer (Mus musculus)


name: TCF dependent signaling in response to WNT (Mus musculus)


name: Beta-catenin translocates to the nucleus (Mus musculus)


name: USP34 deubiquitinates AXIN1,AXIN2 (Mus musculus)


name: Canonical WNT signaling through the atypical receptor RYK (Mus musculus)


name: WNT ligand biogenesis and trafficking (Rattus norvegicus)


name: WNT ligands traffic to the plasma membrane (Rattus norvegicus)


name: WLS binds WNT ligands in the Golgi (Rattus norvegicus)


name: WLS is endocytosed to the early endosome (Rattus norvegicus)


name: Retromer associates with WLS (Rattus norvegicus)


name: secretion of WNT ligands (Rattus norvegicus)


name: Retromer recycles WLS to the Golgi (Rattus norvegicus)


name: WNTs are secreted in exosomes (Rattus norvegicus)


name: WLS:WNT complex is internalized for maturation into exosomes (Rattus norvegicus)


name: WNT ligands traffic to the Golgi (Rattus norvegicus)


name: WLS dissociates from retromer (Rattus norvegicus)


name: TCF dependent signaling in response to WNT (Rattus norvegicus)


name: Beta-catenin translocates to the nucleus (Rattus norvegicus)


name: Canonical WNT signaling through the atypical receptor RYK (Rattus norvegicus)


name: USP34 deubiquitinates AXIN1,AXIN2 (Rattus norvegicus)


name: WNT ligand biogenesis and trafficking (Canis familiaris)


name: WNTs are secreted in exosomes (Canis familiaris)


name: WNT ligands traffic to the plasma membrane (Canis familiaris)


name: WLS binds WNT ligands in the Golgi (Canis familiaris)


name: WLS is endocytosed to the early endosome (Canis familiaris)


name: WLS:WNT complex is internalized for maturation into exosomes (Canis familiaris)


name: Retromer associates with WLS (Canis familiaris)


name: secretion of WNT ligands (Canis familiaris)


name: Retromer recycles WLS to the Golgi (Canis familiaris)


name: WNT ligands traffic to the Golgi (Canis familiaris)


name: WLS dissociates from retromer (Canis familiaris)


name: TCF dependent signaling in response to WNT (Canis familiaris)


name: Canonical WNT signaling through the atypical receptor RYK (Canis familiaris)


name: USP34 deubiquitinates AXIN1,AXIN2 (Canis familiaris)


name: Beta-catenin translocates to the nucleus (Canis familiaris)


name: WNT ligand biogenesis and trafficking (Bos taurus)


name: Retromer associates with WLS (Bos taurus)


name: WNT ligands traffic to the plasma membrane (Bos taurus)


name: WLS binds WNT ligands in the Golgi (Bos taurus)


name: WLS dissociates from retromer (Bos taurus)


name: WLS is endocytosed to the early endosome (Bos taurus)


name: WLS:WNT complex is internalized for maturation into exosomes (Bos taurus)


name: WNT ligands traffic to the Golgi (Bos taurus)


name: WNTs are secreted in exosomes (Bos taurus)


name: Retromer recycles WLS to the Golgi (Bos taurus)


name: TCF dependent signaling in response to WNT (Bos taurus)


name: USP34 deubiquitinates AXIN1,AXIN2 (Bos taurus)


name: Beta-catenin translocates to the nucleus (Bos taurus)


name: Canonical WNT signaling through the atypical receptor RYK (Bos taurus)


name: WNT ligand biogenesis and trafficking (Sus scrofa)


name: WNTs are secreted in exosomes (Sus scrofa)


name: Retromer recycles WLS to the Golgi (Sus scrofa)


name: WLS:WNT complex is internalized for maturation into exosomes (Sus scrofa)


name: WNT ligands traffic to the Golgi (Sus scrofa)


name: Retromer associates with WLS (Sus scrofa)


name: WNT ligands traffic to the plasma membrane (Sus scrofa)


name: WLS binds WNT ligands in the Golgi (Sus scrofa)


name: WLS is endocytosed to the early endosome (Sus scrofa)


name: WLS dissociates from retromer (Sus scrofa)


name: TCF dependent signaling in response to WNT (Sus scrofa)


name: Canonical WNT signaling through the atypical receptor RYK (Sus scrofa)


name: Beta-catenin translocates to the nucleus (Sus scrofa)


name: USP34 deubiquitinates AXIN1,AXIN2 (Sus scrofa)


name: WNT ligand biogenesis and trafficking (Danio rerio)


name: WNT ligands traffic to the Golgi (Danio rerio)


name: TCF dependent signaling in response to WNT (Danio rerio)


name: Beta-catenin translocates to the nucleus (Danio rerio)


name: WNT ligand biogenesis and trafficking (Xenopus tropicalis)


name: WNT ligands traffic to the Golgi (Xenopus tropicalis)


name: Retromer recycles WLS to the Golgi (Xenopus tropicalis)


name: WLS dissociates from retromer (Xenopus tropicalis)


name: WLS binds WNT ligands in the Golgi (Xenopus tropicalis)


name: WLS:WNT complex is internalized for maturation into exosomes (Xenopus tropicalis)


name: WLS is endocytosed to the early endosome (Xenopus tropicalis)


name: WNTs are secreted in exosomes (Xenopus tropicalis)


name: Retromer associates with WLS (Xenopus tropicalis)


name: WNT ligands traffic to the plasma membrane (Xenopus tropicalis)


name: secretion of WNT ligands (Xenopus tropicalis)


name: TCF dependent signaling in response to WNT (Xenopus tropicalis)


name: Beta-catenin translocates to the nucleus (Xenopus tropicalis)


name: WNT ligand biogenesis and trafficking (Gallus gallus)


name: WNT ligands traffic to the Golgi (Gallus gallus)


name: Retromer recycles WLS to the Golgi (Gallus gallus)


name: WNTs are secreted in exosomes (Gallus gallus)


name: WLS is endocytosed to the early endosome (Gallus gallus)


name: WLS:WNT complex is internalized for maturation into exosomes (Gallus gallus)


name: WLS dissociates from retromer (Gallus gallus)


name: WLS binds WNT ligands in the Golgi (Gallus gallus)


name: secretion of WNT ligands (Gallus gallus)


name: Retromer associates with WLS (Gallus gallus)


name: WNT ligands traffic to the plasma membrane (Gallus gallus)


name: TCF dependent signaling in response to WNT (Gallus gallus)


name: Canonical WNT signaling through the atypical receptor RYK (Gallus gallus)


name: USP34 deubiquitinates AXIN1,AXIN2 (Gallus gallus)


name: Beta-catenin translocates to the nucleus (Gallus gallus)


name: WNT ligand biogenesis and trafficking (Drosophila melanogaster)


name: WLS dissociates from retromer (Drosophila melanogaster)


name: WNTs are secreted in exosomes (Drosophila melanogaster)


name: WNT ligands traffic to the Golgi (Drosophila melanogaster)


name: WLS is endocytosed to the early endosome (Drosophila melanogaster)


name: Retromer associates with WLS (Drosophila melanogaster)


name: WLS:WNT complex is internalized for maturation into exosomes (Drosophila melanogaster)


name: Retromer recycles WLS to the Golgi (Drosophila melanogaster)


name: WLS binds WNT ligands in the Golgi (Drosophila melanogaster)


name: WNT ligands traffic to the plasma membrane (Drosophila melanogaster)


name: secretion of WNT ligands (Drosophila melanogaster)


name: TCF dependent signaling in response to WNT (Drosophila melanogaster)


name: Beta-catenin translocates to the nucleus (Drosophila melanogaster)


name: Canonical WNT signaling through the atypical receptor RYK (Drosophila melanogaster)


name: WNT ligand biogenesis and trafficking (Dictyostelium discoideum)


name: Retromer recycles WLS to the Golgi (Dictyostelium discoideum)


name: WNT ligand biogenesis and trafficking (Schizosaccharomyces pombe)


name: Retromer recycles WLS to the Golgi (Schizosaccharomyces pombe)


name: WNT ligand biogenesis and trafficking (Saccharomyces cerevisiae)


name: Retromer recycles WLS to the Golgi (Saccharomyces cerevisiae)


name: Formation of the ureteric bud (Homo sapiens)


name: Expression of GREM1 in metanephric mesenchyme (Homo sapiens)


name: Expression of WNT11 in the nephric duct (Homo sapiens)


name: Expression of GDNF in metanephric mesenchyme (Homo sapiens)


name: Expression of EYA1 in metanephric mesenchyme (Homo sapiens)


name: Expression of SIX1 in metanephric mesenchyme (Homo sapiens)


name: GDNF from the metanephric mesenchyme binds RET:GFRA1 on the nephric duct (Homo sapiens)


name: EYA1, PAX2, and HOX11 paralog bind the SIX2 gene (Homo sapiens)


name: NPNT from the nephric duct binds ITGA8 on the metanephric mesenchyme (Homo sapiens)


name: EYA1, PAX2, and HOX11 paralog bind the GDNF gene (Homo sapiens)


name: Expression of PAX2 in metanephric mesenchyme (Homo sapiens)


name: Expression of SIX2 in metanephric mesenchyme (Homo sapiens)


name: Expression of SALL1 in metanephric mesenchyme (Homo sapiens)


name: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Caenorhabditis elegans)


name: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)


name: TP53 stimulates ARID3A gene expression (Homo sapiens)


name: E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter (Homo sapiens)


name: TP53 stimulates PCBP4 expression (Homo sapiens)


name: E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression (Homo sapiens)


name: TP53 binds the PCBP4 gene (Homo sapiens)


name: TP53 binds the ARID3A gene (Homo sapiens)


name: TP53 stimulates E2F7 expression (Homo sapiens)


name: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Mus musculus)


name: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Rattus norvegicus)


name: E2F8 forms homodimers (Rattus norvegicus)


name: E2F7 forms homodimers (Rattus norvegicus)


name: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Canis familiaris)


name: E2F8 forms homodimers (Canis familiaris)


name: E2F7 forms homodimers (Canis familiaris)


name: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Bos taurus)


name: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Sus scrofa)


name: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Danio rerio)


name: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Xenopus tropicalis)


name: E2F7 forms homodimers (Xenopus tropicalis)


name: E2F8 forms homodimers (Xenopus tropicalis)


name: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Gallus gallus)


name: TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Drosophila melanogaster)


name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Caenorhabditis elegans)


name: SFN dimer binds CDK1 and CCNB1 (Caenorhabditis elegans)


name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)


name: TP53 and E2F4 bind the CDC25C gene (Homo sapiens)


name: TP53 and E2F4 inhibit CDC25C expression (Homo sapiens)


name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription (Homo sapiens)


name: TP53 stimulates SFN expression (Homo sapiens)


name: SFN dimer binds CDK1 and CCNB1 (Homo sapiens)


name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter (Homo sapiens)


name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Mus musculus)


name: SFN dimer binds CDK1 and CCNB1 (Mus musculus)


name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Rattus norvegicus)


name: SFN dimer binds CDK1 and CCNB1 (Rattus norvegicus)


name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Canis familiaris)


name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Bos taurus)


name: SFN dimer binds CDK1 and CCNB1 (Bos taurus)


name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Sus scrofa)


name: SFN dimer binds CDK1 and CCNB1 (Sus scrofa)


name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Danio rerio)


name: SFN dimer binds CDK1 and CCNB1 (Danio rerio)


name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Xenopus tropicalis)


name: GADD45A binds AURKA (Xenopus tropicalis)


name: SFN dimer binds CDK1 and CCNB1 (Xenopus tropicalis)


name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Gallus gallus)


name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Drosophila melanogaster)


name: GADD45A binds AURKA (Drosophila melanogaster)


name: SFN dimer binds CDK1 and CCNB1 (Drosophila melanogaster)


name: GADD45A binds PCNA (Drosophila melanogaster)


name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Plasmodium falciparum)


name: Regulation of TP53 Activity through Acetylation (Caenorhabditis elegans)


name: AKT phosphorylates KAT6A (Caenorhabditis elegans)


name: MTA2-NuRD complex deacetylates TP53 (Caenorhabditis elegans)


name: KAT6A acetylates TP53 (Caenorhabditis elegans)


name: PI5P Regulates TP53 Acetylation (Caenorhabditis elegans)


name: MAP2K6 phosphorylates PIP4K2B (Caenorhabditis elegans)


name: PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Caenorhabditis elegans)


name: TMEM55B translocates to the nucleus (Caenorhabditis elegans)


name: PIN1 binds phosphorylated PIP4K2B (Caenorhabditis elegans)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Caenorhabditis elegans)


name: PI5P Regulates TP53 Acetylation (Homo sapiens)


name: TMEM55B translocates to the nucleus (Homo sapiens)


name: PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Homo sapiens)


name: MAP2K6 phosphorylates PIP4K2B (Homo sapiens)


name: PIN1 binds phosphorylated PIP4K2B (Homo sapiens)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Homo sapiens)


name: ING2-bound EP300 acetylates TP53 (Homo sapiens)


name: ING2 recruits EP300 to TP53 (Homo sapiens)


name: PI5P Regulates TP53 Acetylation (Mus musculus)


name: PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Mus musculus)


name: ING2 recruits EP300 to TP53 (Mus musculus)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Mus musculus)


name: TMEM55B translocates to the nucleus (Mus musculus)


name: ING2-bound EP300 acetylates TP53 (Mus musculus)


name: PIN1 binds phosphorylated PIP4K2B (Mus musculus)


name: MAP2K6 phosphorylates PIP4K2B (Mus musculus)


name: PI5P Regulates TP53 Acetylation (Rattus norvegicus)


name: PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Rattus norvegicus)


name: ING2-bound EP300 acetylates TP53 (Rattus norvegicus)


name: PIN1 binds phosphorylated PIP4K2B (Rattus norvegicus)


name: MAP2K6 phosphorylates PIP4K2B (Rattus norvegicus)


name: TMEM55B translocates to the nucleus (Rattus norvegicus)


name: ING2 recruits EP300 to TP53 (Rattus norvegicus)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Rattus norvegicus)


name: PI5P Regulates TP53 Acetylation (Canis familiaris)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Canis familiaris)


name: TMEM55B translocates to the nucleus (Canis familiaris)


name: MAP2K6 phosphorylates PIP4K2B (Canis familiaris)


name: ING2 recruits EP300 to TP53 (Canis familiaris)


name: ING2-bound EP300 acetylates TP53 (Canis familiaris)


name: PIN1 binds phosphorylated PIP4K2B (Canis familiaris)


name: PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Canis familiaris)


name: PI5P Regulates TP53 Acetylation (Bos taurus)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Bos taurus)


name: PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Bos taurus)


name: MAP2K6 phosphorylates PIP4K2B (Bos taurus)


name: ING2 recruits EP300 to TP53 (Bos taurus)


name: ING2-bound EP300 acetylates TP53 (Bos taurus)


name: PIN1 binds phosphorylated PIP4K2B (Bos taurus)


name: TMEM55B translocates to the nucleus (Bos taurus)


name: PI5P Regulates TP53 Acetylation (Sus scrofa)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Sus scrofa)


name: ING2 recruits EP300 to TP53 (Sus scrofa)


name: ING2-bound EP300 acetylates TP53 (Sus scrofa)


name: MAP2K6 phosphorylates PIP4K2B (Sus scrofa)


name: TMEM55B translocates to the nucleus (Sus scrofa)


name: PIN1 binds phosphorylated PIP4K2B (Sus scrofa)


name: PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Sus scrofa)


name: PI5P Regulates TP53 Acetylation (Danio rerio)


name: PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Danio rerio)


name: TMEM55B translocates to the nucleus (Danio rerio)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Danio rerio)


name: PI5P Regulates TP53 Acetylation (Xenopus tropicalis)


name: PIN1 binds phosphorylated PIP4K2B (Xenopus tropicalis)


name: MAP2K6 phosphorylates PIP4K2B (Xenopus tropicalis)


name: ING2-bound EP300 acetylates TP53 (Xenopus tropicalis)


name: PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Xenopus tropicalis)


name: TMEM55B translocates to the nucleus (Xenopus tropicalis)


name: ING2 recruits EP300 to TP53 (Xenopus tropicalis)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Xenopus tropicalis)


name: PI5P Regulates TP53 Acetylation (Gallus gallus)


name: PIN1 binds phosphorylated PIP4K2B (Gallus gallus)


name: MAP2K6 phosphorylates PIP4K2B (Gallus gallus)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Gallus gallus)


name: PI5P Regulates TP53 Acetylation (Drosophila melanogaster)


name: MAP2K6 phosphorylates PIP4K2B (Drosophila melanogaster)


name: ING2 recruits EP300 to TP53 (Drosophila melanogaster)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Drosophila melanogaster)


name: PIN1 binds phosphorylated PIP4K2B (Drosophila melanogaster)


name: PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Drosophila melanogaster)


name: ING2-bound EP300 acetylates TP53 (Drosophila melanogaster)


name: TMEM55B translocates to the nucleus (Drosophila melanogaster)


name: ING2 binds PI5P (Drosophila melanogaster)


name: PI5P Regulates TP53 Acetylation (Dictyostelium discoideum)


name: MAP2K6 phosphorylates PIP4K2B (Dictyostelium discoideum)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Dictyostelium discoideum)


name: PIN1 binds phosphorylated PIP4K2B (Dictyostelium discoideum)


name: PI5P Regulates TP53 Acetylation (Schizosaccharomyces pombe)


name: PIN1 binds phosphorylated PIP4K2B (Schizosaccharomyces pombe)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Schizosaccharomyces pombe)


name: ING2 binds PI5P (Schizosaccharomyces pombe)


name: PI5P Regulates TP53 Acetylation (Saccharomyces cerevisiae)


name: ING2 binds PI5P (Saccharomyces cerevisiae)


name: PIN1 binds phosphorylated PIP4K2B (Saccharomyces cerevisiae)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Saccharomyces cerevisiae)


name: PI5P Regulates TP53 Acetylation (Plasmodium falciparum)


name: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Plasmodium falciparum)


name: Regulation of TP53 Activity through Acetylation (Homo sapiens)


name: BRD7 binds TP53 and EP300 (Homo sapiens)


name: MTA2-NuRD complex deacetylates TP53 (Homo sapiens)


name: BRD7 promotes EP300-mediated acetylation of TP53 (Homo sapiens)


name: Regulation of TP53 Activity through Acetylation (Mus musculus)


name: BRD7 promotes EP300-mediated acetylation of TP53 (Mus musculus)


name: BRD7 binds TP53 and EP300 (Mus musculus)


name: MTA2-NuRD complex deacetylates TP53 (Mus musculus)


name: Regulation of TP53 Activity through Acetylation (Rattus norvegicus)


name: KAT6A and PML bind TP53 (Rattus norvegicus)


name: AKT phosphorylates KAT6A (Rattus norvegicus)


name: MTA2-NuRD complex deacetylates TP53 (Rattus norvegicus)


name: BRD7 binds TP53 and EP300 (Rattus norvegicus)


name: KAT6A acetylates TP53 (Rattus norvegicus)


name: BRD7 promotes EP300-mediated acetylation of TP53 (Rattus norvegicus)


name: Regulation of TP53 Activity through Acetylation (Canis familiaris)


name: MTA2-NuRD complex deacetylates TP53 (Canis familiaris)


name: BRD7 promotes EP300-mediated acetylation of TP53 (Canis familiaris)


name: KAT6A and PML bind TP53 (Canis familiaris)


name: BRD7 binds TP53 and EP300 (Canis familiaris)


name: KAT6A acetylates TP53 (Canis familiaris)


name: Regulation of TP53 Activity through Acetylation (Bos taurus)


name: MTA2-NuRD complex deacetylates TP53 (Bos taurus)


name: BRD7 promotes EP300-mediated acetylation of TP53 (Bos taurus)


name: Regulation of TP53 Activity through Acetylation (Sus scrofa)


name: MTA2-NuRD complex deacetylates TP53 (Sus scrofa)


name: BRD7 promotes EP300-mediated acetylation of TP53 (Sus scrofa)


name: Regulation of TP53 Activity through Acetylation (Danio rerio)


name: Regulation of TP53 Activity through Acetylation (Xenopus tropicalis)


name: BRD7 promotes EP300-mediated acetylation of TP53 (Xenopus tropicalis)


name: MTA2-NuRD complex deacetylates TP53 (Xenopus tropicalis)


name: BRD7 binds TP53 and EP300 (Xenopus tropicalis)


name: KAT6A acetylates TP53 (Xenopus tropicalis)


name: Regulation of TP53 Activity through Acetylation (Gallus gallus)


name: AKT phosphorylates KAT6A (Gallus gallus)


name: Regulation of TP53 Activity through Acetylation (Drosophila melanogaster)


name: BRD7 promotes EP300-mediated acetylation of TP53 (Drosophila melanogaster)


name: BRD7 binds TP53 and EP300 (Drosophila melanogaster)


name: KAT6A acetylates TP53 (Drosophila melanogaster)


name: AKT phosphorylates KAT6A (Drosophila melanogaster)


name: MTA2-NuRD complex deacetylates TP53 (Drosophila melanogaster)


name: KAT6A and PML bind TP53 (Drosophila melanogaster)


name: Regulation of TP53 Activity through Acetylation (Dictyostelium discoideum)


name: AKT phosphorylates KAT6A (Dictyostelium discoideum)


name: Regulation of TP53 Activity through Acetylation (Schizosaccharomyces pombe)


name: AKT phosphorylates KAT6A (Schizosaccharomyces pombe)


name: Regulation of TP53 Activity through Methylation (Caenorhabditis elegans)


name: CHEK2 phosphorylates TTC5 (Caenorhabditis elegans)


name: Regulation of TP53 Activity through Methylation (Homo sapiens)


name: TP53 binds the complex of JMY, EP300 and TTC5 (Homo sapiens)


name: L3MBTL1 binds TP53 monomethylated on K382 (Homo sapiens)


name: EHMT1:EHMT2 dimethylates TP53 (Homo sapiens)


name: CHEK2 phosphorylates TTC5 (Homo sapiens)


name: Regulation of TP53 Activity through Methylation (Mus musculus)


name: TP53 binds the complex of JMY, EP300 and TTC5 (Mus musculus)


name: CHEK2 phosphorylates TTC5 (Mus musculus)


name: EHMT1:EHMT2 dimethylates TP53 (Mus musculus)


name: L3MBTL1 binds TP53 monomethylated on K382 (Mus musculus)


name: Regulation of TP53 Activity through Methylation (Rattus norvegicus)


name: EHMT1:EHMT2 dimethylates TP53 (Rattus norvegicus)


name: MDM2 ubiquitinates JMY (Rattus norvegicus)


name: TP53 binds the complex of JMY, EP300 and TTC5 (Rattus norvegicus)


name: SMYD2 methylates TP53 (Rattus norvegicus)


name: JMY, TTC5 and EP300 bind (Rattus norvegicus)


name: L3MBTL1 binds TP53 monomethylated on K382 (Rattus norvegicus)


name: SETD8 methylates TP53 (Rattus norvegicus)


name: PRMT5 methylates TP53 (Rattus norvegicus)


name: ATM phosphorylates TTC5 (Rattus norvegicus)


name: CHEK2 phosphorylates TTC5 (Rattus norvegicus)


name: Regulation of TP53 Activity through Methylation (Canis familiaris)


name: JMY, TTC5 and EP300 bind (Canis familiaris)


name: L3MBTL1 binds TP53 monomethylated on K382 (Canis familiaris)


name: CHEK2 phosphorylates TTC5 (Canis familiaris)


name: TP53 binds the complex of JMY, EP300 and TTC5 (Canis familiaris)


name: EHMT1:EHMT2 dimethylates TP53 (Canis familiaris)


name: PRMT5 methylates TP53 (Canis familiaris)


name: ATM phosphorylates TTC5 (Canis familiaris)


name: SETD9 methylates TP53 (Canis familiaris)


name: SMYD2 methylates TP53 (Canis familiaris)


name: MDM2 ubiquitinates JMY (Canis familiaris)


name: Regulation of TP53 Activity through Methylation (Bos taurus)


name: TP53 binds the complex of JMY, EP300 and TTC5 (Bos taurus)


name: EHMT1:EHMT2 dimethylates TP53 (Bos taurus)


name: L3MBTL1 binds TP53 monomethylated on K382 (Bos taurus)


name: Regulation of TP53 Activity through Methylation (Sus scrofa)


name: EHMT1:EHMT2 dimethylates TP53 (Sus scrofa)


name: TP53 binds the complex of JMY, EP300 and TTC5 (Sus scrofa)


name: L3MBTL1 binds TP53 monomethylated on K382 (Sus scrofa)


name: Regulation of TP53 Activity through Methylation (Danio rerio)


name: Regulation of TP53 Activity through Methylation (Xenopus tropicalis)


name: EHMT1:EHMT2 dimethylates TP53 (Xenopus tropicalis)


name: PRMT5 methylates TP53 (Xenopus tropicalis)


name: SETD8 methylates TP53 (Xenopus tropicalis)


name: MDM2 ubiquitinates JMY (Xenopus tropicalis)


name: Regulation of TP53 Activity through Methylation (Gallus gallus)


name: Regulation of TP53 Activity through Methylation (Drosophila melanogaster)


name: SETD8 methylates TP53 (Drosophila melanogaster)


name: L3MBTL1 binds TP53 monomethylated on K382 (Drosophila melanogaster)


name: SMYD2 methylates TP53 (Drosophila melanogaster)


name: EHMT1:EHMT2 dimethylates TP53 (Drosophila melanogaster)


name: Regulation of TP53 Activity through Methylation (Dictyostelium discoideum)


name: CHEK2 phosphorylates TTC5 (Dictyostelium discoideum)


name: ATM phosphorylates TTC5 (Dictyostelium discoideum)


name: Regulation of TP53 Activity through Phosphorylation (Caenorhabditis elegans)


name: Regulation of TP53 Degradation (Caenorhabditis elegans)


name: Regulation of TP53 Degradation (Homo sapiens)


name: CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)


name: DAXX binds Ub-MDM2 and USP7 (Homo sapiens)


name: TP53 stimulates CCNG1 gene expression (Homo sapiens)


name: USP7 deubiquitinates MDM2 (Homo sapiens)


name: TP53 binds the CCNG1 gene (Homo sapiens)


name: (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Homo sapiens)


name: p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)


name: USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)


name: MDM2 translocates to the nucleus (Homo sapiens)


name: MDM2 homodimers auto-ubiquitinate (Homo sapiens)


name: MDM2 translocates to the cytosol (Homo sapiens)


name: TP53 stimulates MDM2 transcription (Homo sapiens)


name: PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)


name: USP2 binds the heterodimer of MDM2 and MDM4 (Homo sapiens)


name: RNF34 or RFFL ubiquitinates phosphorylated TP53 (Homo sapiens)


name: USP7 deubiquitinates TP53 and counteracts MDM2 (Homo sapiens)


name: Regulation of TP53 Degradation (Mus musculus)


name: DAXX binds Ub-MDM2 and USP7 (Mus musculus)


name: RNF34 or RFFL ubiquitinates phosphorylated TP53 (Mus musculus)


name: USP2 binds the heterodimer of MDM2 and MDM4 (Mus musculus)


name: USP2 deubiquitinates MDM2,MDM4 (Mus musculus)


name: USP7 deubiquitinates MDM2 (Mus musculus)


name: MDM2 translocates to the nucleus (Mus musculus)


name: CCNG1 recruits PP2A-PPP2R5C to MDM2 (Mus musculus)


name: (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Mus musculus)


name: PP2A-PP2R5C dephosphorylates MDM2 (Mus musculus)


name: MDM2 translocates to the cytosol (Mus musculus)


name: USP7 deubiquitinates TP53 and counteracts MDM2 (Mus musculus)


name: MDM2 homodimers auto-ubiquitinate (Mus musculus)


name: Regulation of TP53 Degradation (Rattus norvegicus)


name: RNF34 or RFFL ubiquitinates phosphorylated TP53 (Rattus norvegicus)


name: USP7 deubiquitinates TP53 and counteracts MDM2 (Rattus norvegicus)


name: USP2 binds the heterodimer of MDM2 and MDM4 (Rattus norvegicus)


name: MDM2 translocates to the cytosol (Rattus norvegicus)


name: PP2A-PP2R5C dephosphorylates MDM2 (Rattus norvegicus)


name: DAXX binds Ub-MDM2 and USP7 (Rattus norvegicus)


name: SGK1 phosphorylates MDM2 (Rattus norvegicus)


name: USP2 deubiquitinates MDM2,MDM4 (Rattus norvegicus)


name: MDM2 homodimers auto-ubiquitinate (Rattus norvegicus)


name: MDM2 translocates to the nucleus (Rattus norvegicus)


name: CCNG1 recruits PP2A-PPP2R5C to MDM2 (Rattus norvegicus)


name: (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Rattus norvegicus)


name: USP7 deubiquitinates MDM2 (Rattus norvegicus)


name: Regulation of TP53 Degradation (Canis familiaris)


name: USP2 binds the heterodimer of MDM2 and MDM4 (Canis familiaris)


name: MDM2 translocates to the nucleus (Canis familiaris)


name: DAXX binds Ub-MDM2 and USP7 (Canis familiaris)


name: PP2A-PP2R5C dephosphorylates MDM2 (Canis familiaris)


name: (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Canis familiaris)


name: CCNG1 recruits PP2A-PPP2R5C to MDM2 (Canis familiaris)


name: SGK1 phosphorylates MDM2 (Canis familiaris)


name: MDM2 translocates to the cytosol (Canis familiaris)


name: USP7 deubiquitinates MDM2 (Canis familiaris)


name: MDM2 homodimers auto-ubiquitinate (Canis familiaris)


name: USP2 deubiquitinates MDM2,MDM4 (Canis familiaris)


name: USP7 deubiquitinates TP53 and counteracts MDM2 (Canis familiaris)


name: RNF34 or RFFL ubiquitinates phosphorylated TP53 (Canis familiaris)


name: Regulation of TP53 Degradation (Bos taurus)


name: USP7 deubiquitinates TP53 and counteracts MDM2 (Bos taurus)


name: PP2A-PP2R5C dephosphorylates MDM2 (Bos taurus)


name: DAXX binds Ub-MDM2 and USP7 (Bos taurus)


name: RNF34 or RFFL ubiquitinates phosphorylated TP53 (Bos taurus)


name: MDM2 translocates to the nucleus (Bos taurus)


name: (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Bos taurus)


name: CCNG1 recruits PP2A-PPP2R5C to MDM2 (Bos taurus)


name: MDM2 homodimers auto-ubiquitinate (Bos taurus)


name: MDM2 translocates to the cytosol (Bos taurus)


name: Regulation of TP53 Degradation (Sus scrofa)


name: MDM2 translocates to the nucleus (Sus scrofa)


name: RNF34 or RFFL ubiquitinates phosphorylated TP53 (Sus scrofa)


name: MDM2 homodimers auto-ubiquitinate (Sus scrofa)


name: MDM2 translocates to the cytosol (Sus scrofa)


name: DAXX binds Ub-MDM2 and USP7 (Sus scrofa)


name: PP2A-PP2R5C dephosphorylates MDM2 (Sus scrofa)


name: (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Sus scrofa)


name: USP7 deubiquitinates TP53 and counteracts MDM2 (Sus scrofa)


name: CCNG1 recruits PP2A-PPP2R5C to MDM2 (Sus scrofa)


name: Regulation of TP53 Degradation (Danio rerio)


name: MDM2 homodimers auto-ubiquitinate (Danio rerio)


name: RNF34 or RFFL ubiquitinates phosphorylated TP53 (Danio rerio)


name: MDM2 translocates to the nucleus (Danio rerio)


name: (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Danio rerio)


name: MDM2 translocates to the cytosol (Danio rerio)


name: Regulation of TP53 Degradation (Xenopus tropicalis)


name: MDM2 homodimers auto-ubiquitinate (Xenopus tropicalis)


name: MDM2 translocates to the nucleus (Xenopus tropicalis)


name: CCNG1 recruits PP2A-PPP2R5C to MDM2 (Xenopus tropicalis)


name: (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Xenopus tropicalis)


name: MDM2 translocates to the cytosol (Xenopus tropicalis)


name: PP2A-PP2R5C dephosphorylates MDM2 (Xenopus tropicalis)


name: RNF34 or RFFL ubiquitinates phosphorylated TP53 (Xenopus tropicalis)


name: Regulation of TP53 Degradation (Gallus gallus)


name: MDM2 translocates to the nucleus (Gallus gallus)


name: (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Gallus gallus)


name: MDM2 translocates to the cytosol (Gallus gallus)


name: MDM2 homodimers auto-ubiquitinate (Gallus gallus)


name: SGK1 phosphorylates MDM2 (Gallus gallus)


name: Regulation of TP53 Degradation (Drosophila melanogaster)


name: RNF34 or RFFL ubiquitinates phosphorylated TP53 (Drosophila melanogaster)


name: USP7 deubiquitinates TP53 and counteracts MDM2 (Drosophila melanogaster)


name: Regulation of TP53 Degradation (Dictyostelium discoideum)


name: PDPK1 phosphorylates SGK1 (Dictyostelium discoideum)


name: TORC2 complex phosphorylates SGK1 (Dictyostelium discoideum)


name: Regulation of TP53 Degradation (Schizosaccharomyces pombe)


name: PDPK1 phosphorylates SGK1 (Schizosaccharomyces pombe)


name: TORC2 complex phosphorylates SGK1 (Schizosaccharomyces pombe)


name: Regulation of TP53 Degradation (Saccharomyces cerevisiae)


name: TORC2 complex phosphorylates SGK1 (Saccharomyces cerevisiae)


name: PDPK1 phosphorylates SGK1 (Saccharomyces cerevisiae)


name: Regulation of TP53 Expression (Homo sapiens)


name: PRDM1 represses TP53 expression (Homo sapiens)


name: TP53 binds the PRDM1 gene (Homo sapiens)


name: TP53 stimulates PRDM1 expression (Homo sapiens)


name: PRDM1 binds the TP53 gene (Homo sapiens)


name: Regulation of TP53 Expression (Mus musculus)


name: Regulation of TP53 Expression (Rattus norvegicus)


name: TP53 forms homotetramers (Rattus norvegicus)


name: Regulation of TP53 Expression (Canis familiaris)


name: TP53 forms homotetramers (Canis familiaris)


name: Regulation of TP53 Expression (Bos taurus)


name: Regulation of TP53 Expression (Sus scrofa)


name: Regulation of TP53 Expression (Danio rerio)


name: Regulation of TP53 Expression (Xenopus tropicalis)


name: TP53 forms homotetramers (Xenopus tropicalis)


name: Regulation of TP53 Expression (Drosophila melanogaster)


name: TP53 forms homotetramers (Drosophila melanogaster)


name: Regulation of TP53 Activity through Phosphorylation (Homo sapiens)


name: TP53RK phosphorylates TP53 (Homo sapiens)


name: DYRK2 phosphorylates TP53 (Homo sapiens)


name: STK11 (LKB1) phosphorylates NUAK1 (Homo sapiens)


name: AURKA phosphorylates TP53 (Homo sapiens)


name: TP53 binds STK11 and NUAK1 (Homo sapiens)


name: HIPK2 phosphorylates TP53 (Homo sapiens)


name: MAPKAPK5 phosphorylates TP53 (Homo sapiens)


name: AURKB phosphorylates TP53 (Homo sapiens)


name: TP53INP1 and HIPK2 bind TP53 (Homo sapiens)


name: CK2:FACT phosphorylates TP53 (Homo sapiens)


name: NUAK1 phosphorylates TP53 (Homo sapiens)


name: Oxidative Stress Induced Senescence (Homo sapiens)


name: MAP3K5 phosphorylates MKK3 and MKK6 (Homo sapiens)


name: ROS oxidize thioredoxin and activate MAP3K5 (Homo sapiens)


name: E2F1/2/3:DP1/2 binds EED gene promoter (Homo sapiens)


name: Formation of PRC2-EZH2 complex (Homo sapiens)


name: E2F1/2/3:DP1/2 binds SUZ12 gene promoter (Homo sapiens)


name: miR-24 binds p16INK4A and p14ARF mRNAs (Homo sapiens)


name: PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)


name: MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1) (Homo sapiens)


name: Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)


name: PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Homo sapiens)


name: Active p38 MAPK phosphorylates MAPKAPK5 (Homo sapiens)


name: p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)


name: E2F1/2/3 stimulates SUZ12 transcription (Homo sapiens)


name: MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription (Homo sapiens)


name: AP-1 complex stimulates KDM6B transcription (Homo sapiens)


name: Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Homo sapiens)


name: Translation of p14ARF mRNA is inhibited by miR-24 (Homo sapiens)


name: Translation of p16INK4A mRNA is inhibited by miR-24 (Homo sapiens)


name: KDM6B demethylates H3K27me3 on p16INK4A promoter (Homo sapiens)


name: ERK1/2-activated AP1 complex binds KDM6B promoter (Homo sapiens)


name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) (Homo sapiens)


name: E2F1/2/3:DP1/2 binds EZH2 gene promoter (Homo sapiens)


name: Expression of MINK1/TNIK is positively regulated by ROS (Homo sapiens)


name: p14ARF translocates to the nucleus (Homo sapiens)


name: E2F1/2/3 stimulates EZH2 transcription (Homo sapiens)


name: E2F1/2/3 stimulates EED transcription (Homo sapiens)


name: DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)


name: TP53 binds the CDKN1A promoter (Homo sapiens)


name: KAT5 acetylates ATM at shortened telomeres (Homo sapiens)


name: EP400 binds CDKN1A promoter (Homo sapiens)


name: MRN complex binds shortened telomeres (Homo sapiens)


name: MRN complex bound to shortened telomeres recruits ATM (Homo sapiens)


name: Telomere shortening during replicative exhaustion (Homo sapiens)


name: Transcriptional activation of CDKN1A by TP53 is inhibited by EP400 (Homo sapiens)


name: MRN bound to shortened telomeres activates ATM (Homo sapiens)


name: Oncogene Induced Senescence (Homo sapiens)


name: Phosphorylated ETS2 binds p16INK4A promoter (Homo sapiens)


name: E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA (Homo sapiens)


name: Phosphorylated ETS1 binds p16INK4A promoter (Homo sapiens)


name: ERF inhibits ETS2 expression (Homo sapiens)


name: MAPKs phosphorylate ETS1 and ETS2 (Homo sapiens)


name: Phosphorylated ERF translocates to the cytosol (Homo sapiens)


name: Activated ERKs phosphorylate ERF (Homo sapiens)


name: E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter (Homo sapiens)


name: p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA (Homo sapiens)


name: Signaling by RAS GAP mutants (Homo sapiens)


name: RAS GAP mutants aren't stimulated by GAPs (Homo sapiens)


name: Signaling by RAS GTPase mutants (Homo sapiens)


name: RAS GTPase mutants don't hydrolyze GTP (Homo sapiens)


name: Signaling downstream of RAS mutants (Homo sapiens)


name: Homo- or heterodimerization of RAF downstream of mutant RAS (Homo sapiens)


name: Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)


name: RAF is phosphorylated downstream of oncogenic RAS  (Homo sapiens)


name: RAS mutants bind inactive RAF (Homo sapiens)


name: Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)


name: Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)


name: Dissociation of oncogenic RAS:RAF complex (Homo sapiens)


name: Signaling by MAPK mutants (Homo sapiens)


name: Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs (Homo sapiens)


name: Signaling by high-kinase activity BRAF mutants (Homo sapiens)


name: Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance (Homo sapiens)


name: High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)


name: High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)


name: Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)


name: Dissociation of high activity BRAF complexes (Homo sapiens)


name: Inhibitors bind and inhibit highly active BRAF mutants (Homo sapiens)


name: Signaling by moderate kinase activity BRAF mutants (Homo sapiens)


name: Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)


name: Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize (Homo sapiens)


name: Dissociation of moderate activity BRAF complexes (Homo sapiens)


name: RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)


name: Moderate kinase activity BRAF mutants bind RAS:GTP (Homo sapiens)


name: RAF is phosphorylated downstream of moderate kinase activity BRAF mutants (Homo sapiens)


name: RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)


name: Signaling by MAP2K mutants (Homo sapiens)


name: MAP2K mutants constitutively phosphorylate MAPKs (Homo sapiens)


name: SHOC2 M1731 mutant abolishes MRAS complex function (Homo sapiens)


name: SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)


name: Gain-of-function MRAS complexes activate RAF signaling (Homo sapiens)


name: Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)


name: Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)


name: Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)


name: Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)


name: Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)


name: RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)


name: RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)


name: RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)


name: Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)


name: Signaling by RAF1 mutants (Homo sapiens)


name: CR2 RAF1 mutants don't bind YWHAB (Homo sapiens)


name: Phosphorylation of RAF1 mutants (Homo sapiens)


name: RAF1 mutants show enhanced heterodimerization with BRAF (Homo sapiens)


name: MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)


name: RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)


name: Dissociation of RAS:RAF1 mutant complex (Homo sapiens)


name: MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)


name: RAS signaling downstream of NF1 loss-of-function variants (Homo sapiens)


name: Loss-of-function NF1 variants don't stimulate RAS GTPase activity (Homo sapiens)


name: Signaling by BRAF and RAF1 fusions (Homo sapiens)


name: MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)


name: p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)


name: p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)


name: Dissociation of BRAF/RAF fusion complex (Homo sapiens)


name: BRAF and RAF fusion mutant dimers are phosphorylated (Homo sapiens)


name: Oncogene Induced Senescence (Mus musculus)


name: Phosphorylated ERF translocates to the cytosol (Mus musculus)


name: MAPKs phosphorylate ETS1 and ETS2 (Mus musculus)


name: Oxidative Stress Induced Senescence (Mus musculus)


name: Formation of PRC2-EZH2 complex (Mus musculus)


name: Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Mus musculus)


name: MAP3K5 phosphorylates MKK3 and MKK6 (Mus musculus)


name: ROS oxidize thioredoxin and activate MAP3K5 (Mus musculus)


name: Active p38 MAPK phosphorylates MAPKAPK5 (Mus musculus)


name: MAPKAPK5 phosphorylates TP53 (Mus musculus)


name: DNA Damage/Telomere Stress Induced Senescence (Mus musculus)


name: EP400 binds CDKN1A promoter (Mus musculus)


name: Telomere shortening during replicative exhaustion (Mus musculus)


name: MRN bound to shortened telomeres activates ATM (Mus musculus)


name: MRN complex binds shortened telomeres (Mus musculus)


name: MRN complex bound to shortened telomeres recruits ATM (Mus musculus)


name: KAT5 acetylates ATM at shortened telomeres (Mus musculus)


name: Oncogene Induced Senescence (Rattus norvegicus)


name: Phosphorylated ERF translocates to the cytosol (Rattus norvegicus)


name: MAPKs phosphorylate ETS1 and ETS2 (Rattus norvegicus)


name: Oxidative Stress Induced Senescence (Rattus norvegicus)


name: Formation of PRC2-EZH2 complex (Rattus norvegicus)


name: ROS oxidize thioredoxin and activate MAP3K5 (Rattus norvegicus)


name: p-MAPKAPK3 phosphorylates BMI1 (Rattus norvegicus)


name: PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Rattus norvegicus)


name: Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Rattus norvegicus)


name: MAP3K5 phosphorylates MKK3 and MKK6 (Rattus norvegicus)


name: PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Rattus norvegicus)


name: KDM6B demethylates H3K27me3 on p16INK4A promoter (Rattus norvegicus)


name: MAPKAPK5 phosphorylates TP53 (Rattus norvegicus)


name: Active p38 MAPK phosphorylates MAPKAPK5 (Rattus norvegicus)


name: DNA Damage/Telomere Stress Induced Senescence (Rattus norvegicus)


name: EP400 binds CDKN1A promoter (Rattus norvegicus)


name: MRN complex bound to shortened telomeres recruits ATM (Rattus norvegicus)


name: MRN complex binds shortened telomeres (Rattus norvegicus)


name: MRN bound to shortened telomeres activates ATM (Rattus norvegicus)


name: Telomere shortening during replicative exhaustion (Rattus norvegicus)


name: KAT5 acetylates ATM at shortened telomeres (Rattus norvegicus)


name: Senescence-Associated Secretory Phenotype (SASP) (Rattus norvegicus)


name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Rattus norvegicus)


name: CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)


name: CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)


name: CEBPB homodimerization (Rattus norvegicus)


name: EHMT1:EHMT2 methylates IL8 promoter (Rattus norvegicus)


name: Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Rattus norvegicus)


name: EHMT1:EHMT2 methylates IL6 promoter (Rattus norvegicus)


name: Cdh1:APC/C complex binds EHMT1:EHMT2 (Rattus norvegicus)


name: IL-6-type cytokine receptor ligand interactions (Rattus norvegicus)


name: OSM,LIF,CTF1 receptor complex binds gp130 (Rattus norvegicus)


name: gp130:JAKs bind CNTFR (Rattus norvegicus)


name: OSM binds LIFR:JAKs,OSMR:JAKs (Rattus norvegicus)


name: CRLF1:CLCF1 binds CNTRF (Rattus norvegicus)


name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Rattus norvegicus)


name: LIFR:JAKs bind gp130:JAKs:CNTFR (Rattus norvegicus)


name: CTF1 binds LIFR:JAKs (Rattus norvegicus)


name: CNTF binds CNTFR complex (Rattus norvegicus)


name: IL31:IL31RA:JAK1 binds OSMR:JAK1 (Rattus norvegicus)


name: IL-6-type cytokine receptor ligand interactions (Homo sapiens)


name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)


name: IL31:IL31RA:JAK1 binds OSMR:JAK1 (Homo sapiens)


name: OSM binds LIFR:JAKs,OSMR:JAKs (Homo sapiens)


name: OSM,LIF,CTF1 receptor complex binds gp130 (Homo sapiens)


name: LIFR:JAKs bind gp130:JAKs:CNTFR (Homo sapiens)


name: IL-6-type cytokine receptor ligand interactions (Mus musculus)


name: OSM binds LIFR:JAKs,OSMR:JAKs (Mus musculus)


name: IL31:IL31RA:JAK1 binds OSMR:JAK1 (Mus musculus)


name: LIFR:JAKs bind gp130:JAKs:CNTFR (Mus musculus)


name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Mus musculus)


name: OSM,LIF,CTF1 receptor complex binds gp130 (Mus musculus)


name: IL-6-type cytokine receptor ligand interactions (Canis familiaris)


name: CRLF1:CLCF1 binds CNTRF (Canis familiaris)


name: IL31:IL31RA:JAK1 binds OSMR:JAK1 (Canis familiaris)


name: gp130:JAKs bind CNTFR (Canis familiaris)


name: OSM,LIF,CTF1 receptor complex binds gp130 (Canis familiaris)


name: LIFR:JAKs bind gp130:JAKs:CNTFR (Canis familiaris)


name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Canis familiaris)


name: OSM binds LIFR:JAKs,OSMR:JAKs (Canis familiaris)


name: IL-6-type cytokine receptor ligand interactions (Bos taurus)


name: OSM binds LIFR:JAKs,OSMR:JAKs (Bos taurus)


name: LIFR:JAKs bind gp130:JAKs:CNTFR (Bos taurus)


name: OSM,LIF,CTF1 receptor complex binds gp130 (Bos taurus)


name: IL-6-type cytokine receptor ligand interactions (Sus scrofa)


name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Sus scrofa)


name: LIFR:JAKs bind gp130:JAKs:CNTFR (Sus scrofa)


name: IL31:IL31RA:JAK1 binds OSMR:JAK1 (Sus scrofa)


name: OSM,LIF,CTF1 receptor complex binds gp130 (Sus scrofa)


name: OSM binds LIFR:JAKs,OSMR:JAKs (Sus scrofa)


name: IL-6-type cytokine receptor ligand interactions (Danio rerio)


name: LIFR:JAKs bind gp130:JAKs:CNTFR (Danio rerio)


name: IL-6-type cytokine receptor ligand interactions (Xenopus tropicalis)


name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Xenopus tropicalis)


name: IL-6-type cytokine receptor ligand interactions (Gallus gallus)


name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Gallus gallus)


name: LIFR:JAKs bind gp130:JAKs:CNTFR (Gallus gallus)


name: Interleukin-6 signaling (Rattus norvegicus)


name: Phosphorylated STATs are released (Rattus norvegicus)


name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Rattus norvegicus)


name: IL6R binds IL6R inhibitors (Rattus norvegicus)


name: PTPN11 is phosphorylated (Rattus norvegicus)


name: IL6:IL6R-2 binds IL6ST-2 (Rattus norvegicus)


name: Phosphorylated STAT1, STAT3 form dimers (Rattus norvegicus)


name: Assembly of hexameric IL-6 receptor (Rattus norvegicus)


name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Rattus norvegicus)


name: PTPN11 binds p-Y759-IL6ST (Rattus norvegicus)


name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Rattus norvegicus)


name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Rattus norvegicus)


name: STAT1 and STAT3 dimers translocate to the nucleus (Rattus norvegicus)


name: IL6ST is tyrosine phosphorylated (Rattus norvegicus)


name: Serine phosphorylation of STATs (Rattus norvegicus)


name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)


name: Serine phosphorylation of STATs (Homo sapiens)


name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)


name: Phosphorylated STAT1, STAT3 form dimers (Homo sapiens)


name: Phosphorylated STATs are released (Homo sapiens)


name: JAK1,JAK2,(TYK2) bind IL6ST (Homo sapiens)


name: IL6ST is tyrosine phosphorylated (Homo sapiens)


name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Homo sapiens)


name: PTPN11 binds p-Y759-IL6ST (Homo sapiens)


name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)


name: Assembly of hexameric IL-6 receptor (Homo sapiens)


name: STAT1 and STAT3 dimers translocate to the nucleus (Homo sapiens)


name: IL6R binds IL6R inhibitors (Homo sapiens)

definition: Inhibition


name: Serine phosphorylation of STATs (Mus musculus)


name: STAT1 and STAT3 dimers translocate to the nucleus (Mus musculus)


name: IL6ST is tyrosine phosphorylated (Mus musculus)


name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Mus musculus)


name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Mus musculus)


name: Phosphorylated STATs are released (Mus musculus)


name: IL6R binds IL6R inhibitors (Mus musculus)


name: Assembly of hexameric IL-6 receptor (Mus musculus)


name: Phosphorylated STAT1, STAT3 form dimers (Mus musculus)


name: PTPN11 binds p-Y759-IL6ST (Mus musculus)


name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Mus musculus)


name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Mus musculus)


name: Interleukin-6 signaling (Canis familiaris)


name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Canis familiaris)


name: STAT1 and STAT3 dimers translocate to the nucleus (Canis familiaris)


name: IL6ST is tyrosine phosphorylated (Canis familiaris)


name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Canis familiaris)


name: PTPN11 binds p-Y759-IL6ST (Canis familiaris)


name: Assembly of hexameric IL-6 receptor (Canis familiaris)


name: IL6R binds IL6R inhibitors (Canis familiaris)


name: PTPN11 is phosphorylated (Canis familiaris)


name: Phosphorylated STATs are released (Canis familiaris)


name: Serine phosphorylation of STATs (Canis familiaris)


name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Canis familiaris)


name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Canis familiaris)


name: Phosphorylated STAT1, STAT3 form dimers (Canis familiaris)


name: IL6:IL6R-2 binds IL6ST-2 (Canis familiaris)


name: Phosphorylated STAT1, STAT3 form dimers (Bos taurus)


name: Serine phosphorylation of STATs (Bos taurus)


name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Bos taurus)


name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Bos taurus)


name: IL6ST is tyrosine phosphorylated (Bos taurus)


name: STAT1 and STAT3 dimers translocate to the nucleus (Bos taurus)


name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Bos taurus)


name: Phosphorylated STATs are released (Bos taurus)


name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Bos taurus)


name: Assembly of hexameric IL-6 receptor (Bos taurus)


name: STAT1 and STAT3 dimers translocate to the nucleus (Sus scrofa)


name: Serine phosphorylation of STATs (Sus scrofa)


name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Sus scrofa)


name: Phosphorylated STATs are released (Sus scrofa)


name: Phosphorylated STAT1, STAT3 form dimers (Sus scrofa)


name: Assembly of hexameric IL-6 receptor (Sus scrofa)


name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Sus scrofa)


name: IL6ST is tyrosine phosphorylated (Sus scrofa)


name: IL6R binds IL6R inhibitors (Danio rerio)


name: Phosphorylated STATs are released (Danio rerio)


name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Danio rerio)


name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Danio rerio)


name: STAT1 and STAT3 dimers translocate to the nucleus (Danio rerio)


name: Assembly of hexameric IL-6 receptor (Danio rerio)


name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Danio rerio)


name: Serine phosphorylation of STATs (Danio rerio)


name: Phosphorylated STAT1, STAT3 form dimers (Danio rerio)


name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Danio rerio)


name: IL6ST is tyrosine phosphorylated (Danio rerio)


name: Interleukin-6 signaling (Xenopus tropicalis)


name: PTPN11 binds p-Y759-IL6ST (Xenopus tropicalis)


name: STAT1 and STAT3 dimers translocate to the nucleus (Xenopus tropicalis)


name: Phosphorylated STAT1, STAT3 form dimers (Xenopus tropicalis)


name: PTPN11 is phosphorylated (Xenopus tropicalis)


name: IL6ST is tyrosine phosphorylated (Xenopus tropicalis)


name: Serine phosphorylation of STATs (Xenopus tropicalis)


name: Assembly of hexameric IL-6 receptor (Xenopus tropicalis)


name: Phosphorylated STATs are released (Xenopus tropicalis)


name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Xenopus tropicalis)


name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Xenopus tropicalis)


name: Assembly of hexameric IL-6 receptor (Gallus gallus)


name: IL6R binds IL6R inhibitors (Gallus gallus)


name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Gallus gallus)


name: Phosphorylated STAT1, STAT3 form dimers (Gallus gallus)


name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Gallus gallus)


name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Gallus gallus)


name: Phosphorylated STATs are released (Gallus gallus)


name: Serine phosphorylation of STATs (Gallus gallus)


name: PTPN11 binds p-Y759-IL6ST (Gallus gallus)


name: STAT1 and STAT3 dimers translocate to the nucleus (Gallus gallus)


name: IL6ST is tyrosine phosphorylated (Gallus gallus)


name: IL6:IL6R-2 binds IL6ST-2 (Gallus gallus)


name: PTPN11 is phosphorylated (Gallus gallus)


name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Gallus gallus)


name: Interleukin-6 signaling (Drosophila melanogaster)


name: Phosphorylated STAT1, STAT3 form dimers (Drosophila melanogaster)


name: STAT1 and STAT3 dimers translocate to the nucleus (Drosophila melanogaster)


name: Interleukin-6 signaling (Caenorhabditis elegans)


name: IL6R binds IL6R inhibitors (Caenorhabditis elegans)


name: STAT1 and STAT3 dimers translocate to the nucleus (Caenorhabditis elegans)


name: Phosphorylated STAT1, STAT3 form dimers (Caenorhabditis elegans)


name: Interleukin-6 signaling (Dictyostelium discoideum)


name: Phosphorylated STAT1, STAT3 form dimers (Dictyostelium discoideum)


name: STAT1 and STAT3 dimers translocate to the nucleus (Dictyostelium discoideum)


name: Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)


name: Stimulation of IL8 transcription in senescent cells (Homo sapiens)


name: AP-1 stimulates IL1A transcription (Homo sapiens)


name: Activated CEBPB and NFKB complex bind IL6 promoter (Homo sapiens)


name: AP-1 transcription factor binds IL1A promoter (Homo sapiens)


name: Activated CEBPB and NFKB complex bind IL8 promoter (Homo sapiens)


name: Activated STAT3 positively regulates CEBPB transcription (Homo sapiens)


name: RPS6KA1/2/3 phosphorylates CEBPB on S321 (Homo sapiens)


name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Homo sapiens)


name: Regulation of IL6 transcription (Homo sapiens)


name: AP-1 stimulates transcription of IGFBP7 (Homo sapiens)


name: Cdh1:APC/C complex binds EHMT1:EHMT2 (Homo sapiens)


name: Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Homo sapiens)


name: EHMT1:EHMT2 methylates IL8 promoter (Homo sapiens)


name: EHMT1:EHMT2 methylates IL6 promoter (Homo sapiens)


name: AP-1 transcription factor binds IGFBP7 promoter (Homo sapiens)


name: CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)


name: Activated CEBPB binds CDKN2B promoter (Homo sapiens)


name: CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)


name: Activated CEBPB stimulates transcription of CDKN2B (Homo sapiens)


name: Transcriptional Regulation by VENTX (Homo sapiens)


name: Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1 (Homo sapiens)


name: VENTX binds the IL6 gene promoter (Homo sapiens)


name: VENTX stimulates p16-INK4A transcription (Homo sapiens)


name: VENTX binds the CDKN2A gene (Homo sapiens)


name: VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Homo sapiens)


name: VENTX binds the CSF1R (M-CSF-R) gene promoter (Homo sapiens)


name: VENTX stimulates TP53 gene expression (Homo sapiens)


name: VENTX stimulates CSF1R (M-CSF-R) expression (Homo sapiens)


name: VENTX binds the TP53 gene promoter (Homo sapiens)


name: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)


name: TP53 stimulates PLK2 expression (Homo sapiens)


name: PLK2 phosphorylates CENPJ (Homo sapiens)


name: TP53 stimulates BTG2 expression (Homo sapiens)


name: TP53 stimulates RGCC expression (Homo sapiens)


name: TP53 stimulates PLAGL1 expression (Homo sapiens)


name: TP53 binds the PLAGL1 gene (Homo sapiens)


name: PLK3 phosphorylates CDC25C (Homo sapiens)


name: BTG2 binds CCR4-NOT complex (Homo sapiens)


name: TP53 stimulates PLK3 expression (Homo sapiens)


name: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Mus musculus)


name: PLK3 phosphorylates CDC25C (Mus musculus)


name: PLK2 phosphorylates CENPJ (Mus musculus)


name: BTG2 binds CCR4-NOT complex (Mus musculus)


name: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Rattus norvegicus)


name: PLK3 phosphorylates CDC25C (Rattus norvegicus)


name: PLK2 phosphorylates CENPJ (Rattus norvegicus)


name: BTG2 binds CCR4-NOT complex (Rattus norvegicus)


name: PLK2 phosphorylates NPM1 (Rattus norvegicus)


name: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Canis familiaris)


name: BTG2 binds CCR4-NOT complex (Canis familiaris)


name: PLK2 phosphorylates NPM1 (Canis familiaris)


name: PLK3 phosphorylates CDC25C (Canis familiaris)


name: PLK2 phosphorylates CENPJ (Canis familiaris)


name: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Bos taurus)


name: BTG2 binds CCR4-NOT complex (Bos taurus)


name: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Sus scrofa)


name: BTG2 binds CCR4-NOT complex (Sus scrofa)


name: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Danio rerio)


name: BTG2 binds CCR4-NOT complex (Danio rerio)


name: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Xenopus tropicalis)


name: PLK2 phosphorylates NPM1 (Xenopus tropicalis)


name: BTG2 binds CCR4-NOT complex (Xenopus tropicalis)


name: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Gallus gallus)


name: BTG2 binds CCR4-NOT complex (Gallus gallus)


name: PLK2 phosphorylates CENPJ (Gallus gallus)


name: PLK2 phosphorylates NPM1 (Gallus gallus)


name: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Dictyostelium discoideum)


name: PLK3 phosphorylates CDC25C (Dictyostelium discoideum)


name: BTG2 binds CCR4-NOT complex (Dictyostelium discoideum)


name: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Schizosaccharomyces pombe)


name: PLK3 phosphorylates CDC25C (Schizosaccharomyces pombe)


name: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Saccharomyces cerevisiae)


name: PLK3 phosphorylates CDC25C (Saccharomyces cerevisiae)


name: FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Homo sapiens)


name: Trimerization of the FASL:FAS receptor complex (Homo sapiens)


name: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Homo sapiens)


name: FasL:Fas binds FADD (Homo sapiens)


name: Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)


name: Caspase-8 processing in the DISC (Homo sapiens)


name: Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)


name: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Homo sapiens)


name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Homo sapiens)


name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)


name: Caspase-8 and FLIP(L) processing at DISC (Mus musculus)


name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Mus musculus)


name: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Mus musculus)


name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Mus musculus)


name: Regulation by c-FLIP (Rattus norvegicus)


name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Rattus norvegicus)


name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Rattus norvegicus)


name: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Rattus norvegicus)


name: Caspase-8 and FLIP(L) processing at DISC (Rattus norvegicus)


name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Canis familiaris)


name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Canis familiaris)


name: Caspase-8 and FLIP(L) processing at DISC (Canis familiaris)


name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Bos taurus)


name: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Bos taurus)


name: Caspase-8 and FLIP(L) processing at DISC (Bos taurus)


name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Bos taurus)


name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Sus scrofa)


name: Caspase-8 and FLIP(L) processing at DISC (Sus scrofa)


name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Sus scrofa)


name: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Sus scrofa)


name: Caspase-8 and FLIP(L) processing at DISC (Gallus gallus)


name: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Gallus gallus)


name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)


name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Gallus gallus)


name: Dimerization of procaspase-8 (Homo sapiens)


name: FAS-mediated dimerization of procaspase-8 (Homo sapiens)


name: TRAIL-mediated dimerization of procaspase-8 (Homo sapiens)


name: TNF-mediated dimerization of procaspase-8 (Homo sapiens)


name: Dimerization of procaspase-8 (Mus musculus)


name: FAS-mediated dimerization of procaspase-8 (Mus musculus)


name: TRAIL-mediated dimerization of procaspase-8 (Mus musculus)


name: TNF-mediated dimerization of procaspase-8 (Mus musculus)


name: Dimerization of procaspase-8 (Rattus norvegicus)


name: FAS-mediated dimerization of procaspase-8 (Rattus norvegicus)


name: TNF-mediated dimerization of procaspase-8 (Rattus norvegicus)


name: TRAIL-mediated dimerization of procaspase-8 (Rattus norvegicus)


name: Dimerization of procaspase-8 (Canis familiaris)


name: FAS-mediated dimerization of procaspase-8 (Canis familiaris)


name: TNF-mediated dimerization of procaspase-8 (Canis familiaris)


name: Dimerization of procaspase-8 (Bos taurus)


name: TNF-mediated dimerization of procaspase-8 (Bos taurus)


name: TRAIL-mediated dimerization of procaspase-8 (Bos taurus)


name: FAS-mediated dimerization of procaspase-8 (Bos taurus)


name: Dimerization of procaspase-8 (Sus scrofa)


name: TNF-mediated dimerization of procaspase-8 (Sus scrofa)


name: FAS-mediated dimerization of procaspase-8 (Sus scrofa)


name: TRAIL-mediated dimerization of procaspase-8 (Sus scrofa)


name: Dimerization of procaspase-8 (Gallus gallus)


name: TNF-mediated dimerization of procaspase-8 (Gallus gallus)


name: TRAIL-mediated dimerization of procaspase-8 (Gallus gallus)


name: FAS-mediated dimerization of procaspase-8 (Gallus gallus)


name: Membrane-anchored TNF-α binds TNFR1 (Homo sapiens)


name: TNF-alpha inhibitors bind to TNF(1-233) trimer (Homo sapiens)


name: Soluble TNF-α binds TNFR1 (Homo sapiens)


name: TNF-α is cleaved by ADAM17 (TACE) (Homo sapiens)


name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Homo sapiens)


name: TNF-alpha inhibitors bind to soluble TNF trimer (Homo sapiens)


name: Regulation of TNFR1 signaling (Homo sapiens)


name: Caspase-8 and FLIP(L) processing at TNFR signaling complex (Homo sapiens)


name: K63polyUb-RIPK1 is deubiquitinated (Homo sapiens)


name: RIPK1 is cleaved by CASP8:FLIP(L) (Homo sapiens)


name: OPTN binds polyUb-RIPK1 within the TNFR1 complex (Homo sapiens)


name: SPATA2 links CYLD to LUBAC (Homo sapiens)


name: MIB2 ubiquitinates CYLD at K338, K530 (Homo sapiens)


name: GNB2L1 binds IKKA:IKKB:NEMO (Homo sapiens)


name: SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Homo sapiens)


name: MIB2 ubiquitinates CFLAR  (Homo sapiens)


name: Met1-linked polyubiquitin deubiquitinase activity

description: Catalysis of the hydrolysis of ubiquitin units from Met1-linked (or linear) polyubiquitin chains.


name: CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Homo sapiens)


name: Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 (Homo sapiens)


name: LUBAC ubiquitinates CFLAR at K351, K353 (Homo sapiens)


name: TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Homo sapiens)


name: CHUK, IKBKB phosphorylate CYLD at S418 (Homo sapiens)


name: MAPKAPK2 phosphorylates RIPK1 at S320 (Homo sapiens)


name: LUBAC ubiquitinates RIPK1 at K627 (Homo sapiens)


name: TNF-α:TNFR1 binds DENN/MADD (Homo sapiens)


name: TBK1, IKBKE phosphorylate RIPK1 at T189 (Homo sapiens)


name: TRAF1 is cleaved by caspases (Homo sapiens)


name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Homo sapiens)


name: MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Homo sapiens)


name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Homo sapiens)


name: Viral serpin blocks caspase-8 activity (Homo sapiens)


name: CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)


name: MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)


name: CHUK, IKBKB phosphorylate RIPK1 at S25 (Homo sapiens)


name: STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Homo sapiens)


name: ULK1 phosphorylates RIPK1 at S357 (Homo sapiens)


name: TRAF1 binds TRAF2 within TNFR1 signaling complex (Homo sapiens)


name: CLIP3 and CYLD bind TNF signaling complex (Homo sapiens)


name: SPPL2a/b cleaves TNF(1-76) (Homo sapiens)


name: OPTN recruits CYLD to the TNFR1 complex (Homo sapiens)


name: Regulation of TNFR1 signaling (Mus musculus)


name: TRAF1 binds TRAF2 within TNFR1 signaling complex (Mus musculus)


name: SPPL2a/b cleaves TNF(1-76) (Mus musculus)


name: OPTN binds polyUb-RIPK1 within the TNFR1 complex (Mus musculus)


name: CHUK, IKBKB phosphorylate CYLD at S418 (Mus musculus)


name: Caspase-8 and FLIP(L) processing at TNFR signaling complex (Mus musculus)


name: LUBAC ubiquitinates RIPK1 at K627 (Mus musculus)


name: CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Mus musculus)


name: MIB2 ubiquitinates CFLAR  (Mus musculus)


name: TRAF1 is cleaved by caspases (Mus musculus)


name: K63polyUb-RIPK1 is deubiquitinated (Mus musculus)


name: STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Mus musculus)


name: RIPK1 is cleaved by CASP8:FLIP(L) (Mus musculus)


name: CLIP3 and CYLD bind TNF signaling complex (Mus musculus)


name: CHUK, IKBKB phosphorylate RIPK1 at S25 (Mus musculus)


name: MAPKAPK2 phosphorylates RIPK1 at S320 (Mus musculus)


name: MIB2 ubiquitinates CYLD at K338, K530 (Mus musculus)


name: OPTN recruits CYLD to the TNFR1 complex (Mus musculus)


name: SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Mus musculus)


name: ULK1 phosphorylates RIPK1 at S357 (Mus musculus)


name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Mus musculus)


name: CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Mus musculus)


name: CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Mus musculus)


name: GNB2L1 binds IKKA:IKKB:NEMO (Mus musculus)


name: TBK1, IKBKE phosphorylate RIPK1 at T189 (Mus musculus)


name: TNF-α:TNFR1 binds DENN/MADD (Mus musculus)


name: MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Mus musculus)


name: MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Mus musculus)


name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Mus musculus)


name: TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Mus musculus)


name: Regulation of TNFR1 signaling (Rattus norvegicus)


name: TRAF1 is cleaved by caspases (Rattus norvegicus)


name: ULK1 phosphorylates RIPK1 at S357 (Rattus norvegicus)


name: CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)


name: SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Rattus norvegicus)


name: CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)


name: TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Rattus norvegicus)


name: TBK1, IKBKE phosphorylate RIPK1 at T189 (Rattus norvegicus)


name: MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Rattus norvegicus)


name: MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Rattus norvegicus)


name: OPTN recruits CYLD to the TNFR1 complex (Rattus norvegicus)


name: CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Rattus norvegicus)


name: CHUK, IKBKB phosphorylate CYLD at S418 (Rattus norvegicus)


name: Caspase-8 and FLIP(L) processing at TNFR signaling complex (Rattus norvegicus)


name: TNF-α:TNFR1 binds DENN/MADD (Rattus norvegicus)


name: STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Rattus norvegicus)


name: LUBAC ubiquitinates RIPK1 at K627 (Rattus norvegicus)


name: OPTN binds polyUb-RIPK1 within the TNFR1 complex (Rattus norvegicus)


name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Rattus norvegicus)


name: MIB2 ubiquitinates CFLAR  (Rattus norvegicus)


name: MAPKAPK2 phosphorylates RIPK1 at S320 (Rattus norvegicus)


name: GNB2L1 binds IKKA:IKKB:NEMO (Rattus norvegicus)


name: K63polyUb-RIPK1 is deubiquitinated (Rattus norvegicus)


name: RIPK1 is cleaved by CASP8:FLIP(L) (Rattus norvegicus)


name: CHUK, IKBKB phosphorylate RIPK1 at S25 (Rattus norvegicus)


name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Rattus norvegicus)


name: TRAF1 binds TRAF2 within TNFR1 signaling complex (Rattus norvegicus)


name: SPPL2a/b cleaves TNF(1-76) (Rattus norvegicus)


name: MIB2 ubiquitinates CYLD at K338, K530 (Rattus norvegicus)


name: Regulation of TNFR1 signaling (Canis familiaris)


name: CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)


name: TNF-α:TNFR1 binds DENN/MADD (Canis familiaris)


name: CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)


name: MIB2 ubiquitinates CYLD at K338, K530 (Canis familiaris)


name: GNB2L1 binds IKKA:IKKB:NEMO (Canis familiaris)


name: ULK1 phosphorylates RIPK1 at S357 (Canis familiaris)


name: SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)


name: CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)


name: TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)


name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Canis familiaris)


name: Caspase-8 and FLIP(L) processing at TNFR signaling complex (Canis familiaris)


name: TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)


name: MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Canis familiaris)


name: RIPK1 is cleaved by CASP8:FLIP(L) (Canis familiaris)


name: MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Canis familiaris)


name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Canis familiaris)


name: CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)


name: OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)


name: CHUK, IKBKB phosphorylate CYLD at S418 (Canis familiaris)


name: LUBAC ubiquitinates RIPK1 at K627 (Canis familiaris)


name: OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)


name: STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Canis familiaris)


name: K63polyUb-RIPK1 is deubiquitinated (Canis familiaris)


name: MIB2 ubiquitinates CFLAR  (Canis familiaris)


name: SPPL2a/b cleaves TNF(1-76) (Canis familiaris)


name: CLIP3 and CYLD bind TNF signaling complex (Canis familiaris)


name: Regulation of TNFR1 signaling (Bos taurus)


name: CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Bos taurus)


name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Bos taurus)


name: LUBAC ubiquitinates RIPK1 at K627 (Bos taurus)


name: TRAF1 binds TRAF2 within TNFR1 signaling complex (Bos taurus)


name: OPTN binds polyUb-RIPK1 within the TNFR1 complex (Bos taurus)


name: TRAF1 is cleaved by caspases (Bos taurus)


name: STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Bos taurus)


name: TNF-α:TNFR1 binds DENN/MADD (Bos taurus)


name: GNB2L1 binds IKKA:IKKB:NEMO (Bos taurus)


name: Caspase-8 and FLIP(L) processing at TNFR signaling complex (Bos taurus)


name: MAPKAPK2 phosphorylates RIPK1 at S320 (Bos taurus)


name: CHUK, IKBKB phosphorylate RIPK1 at S25 (Bos taurus)


name: RIPK1 is cleaved by CASP8:FLIP(L) (Bos taurus)


name: MIB2 ubiquitinates CYLD at K338, K530 (Bos taurus)


name: OPTN recruits CYLD to the TNFR1 complex (Bos taurus)


name: CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Bos taurus)


name: SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Bos taurus)


name: ULK1 phosphorylates RIPK1 at S357 (Bos taurus)


name: CHUK, IKBKB phosphorylate CYLD at S418 (Bos taurus)


name: TBK1, IKBKE phosphorylate RIPK1 at T189 (Bos taurus)


name: K63polyUb-RIPK1 is deubiquitinated (Bos taurus)


name: CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Bos taurus)


name: TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Bos taurus)


name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Bos taurus)


name: MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Bos taurus)


name: MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Bos taurus)


name: CLIP3 and CYLD bind TNF signaling complex (Bos taurus)


name: Regulation of TNFR1 signaling (Sus scrofa)


name: OPTN binds polyUb-RIPK1 within the TNFR1 complex (Sus scrofa)


name: CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Sus scrofa)


name: TRAF1 binds TRAF2 within TNFR1 signaling complex (Sus scrofa)


name: K63polyUb-RIPK1 is deubiquitinated (Sus scrofa)


name: Caspase-8 and FLIP(L) processing at TNFR signaling complex (Sus scrofa)


name: TRAF1 is cleaved by caspases (Sus scrofa)


name: STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Sus scrofa)


name: RIPK1 is cleaved by CASP8:FLIP(L) (Sus scrofa)


name: TNF-α:TNFR1 binds DENN/MADD (Sus scrofa)


name: CLIP3 and CYLD bind TNF signaling complex (Sus scrofa)


name: GNB2L1 binds IKKA:IKKB:NEMO (Sus scrofa)


name: MAPKAPK2 phosphorylates RIPK1 at S320 (Sus scrofa)


name: CHUK, IKBKB phosphorylate RIPK1 at S25 (Sus scrofa)


name: OPTN recruits CYLD to the TNFR1 complex (Sus scrofa)


name: MIB2 ubiquitinates CYLD at K338, K530 (Sus scrofa)


name: CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)


name: SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Sus scrofa)


name: ULK1 phosphorylates RIPK1 at S357 (Sus scrofa)


name: TBK1, IKBKE phosphorylate RIPK1 at T189 (Sus scrofa)


name: CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)


name: TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Sus scrofa)


name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Sus scrofa)


name: MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Sus scrofa)


name: MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Sus scrofa)


name: CHUK, IKBKB phosphorylate CYLD at S418 (Sus scrofa)


name: LUBAC ubiquitinates RIPK1 at K627 (Sus scrofa)


name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Sus scrofa)


name: Regulation of TNFR1 signaling (Danio rerio)


name: MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Danio rerio)


name: MIB2 ubiquitinates CYLD at K338, K530 (Danio rerio)


name: MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Danio rerio)


name: K63polyUb-RIPK1 is deubiquitinated (Danio rerio)


name: Regulation of TNFR1 signaling (Xenopus tropicalis)


name: MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Xenopus tropicalis)


name: SPPL2a/b cleaves TNF(1-76) (Xenopus tropicalis)


name: ULK1 phosphorylates RIPK1 at S357 (Xenopus tropicalis)


name: TRAF1 binds TRAF2 within TNFR1 signaling complex (Xenopus tropicalis)


name: Regulation of TNFR1 signaling (Gallus gallus)


name: STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Gallus gallus)


name: RIPK1 is cleaved by CASP8:FLIP(L) (Gallus gallus)


name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Gallus gallus)


name: MIB2 ubiquitinates CYLD at K338, K530 (Gallus gallus)


name: K63polyUb-RIPK1 is deubiquitinated (Gallus gallus)


name: Caspase-8 and FLIP(L) processing at TNFR signaling complex (Gallus gallus)


name: TBK1, IKBKE phosphorylate RIPK1 at T189 (Gallus gallus)


name: TRAF1 is cleaved by caspases (Gallus gallus)


name: ULK1 phosphorylates RIPK1 at S357 (Gallus gallus)


name: MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Gallus gallus)


name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Gallus gallus)


name: MAPKAPK2 phosphorylates RIPK1 at S320 (Gallus gallus)


name: OPTN recruits CYLD to the TNFR1 complex (Gallus gallus)


name: MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Gallus gallus)


name: MIB2 ubiquitinates CFLAR  (Gallus gallus)


name: Regulation of TNFR1 signaling (Drosophila melanogaster)


name: CHUK, IKBKB phosphorylate CYLD at S418 (Drosophila melanogaster)


name: MIB2 ubiquitinates CYLD at K338, K530 (Drosophila melanogaster)


name: MIB2 ubiquitinates CFLAR  (Drosophila melanogaster)


name: GNB2L1 binds IKKA:IKKB:NEMO (Drosophila melanogaster)


name: MIB2 binds CFLAR (Drosophila melanogaster)


name: Regulation of TNFR1 signaling (Caenorhabditis elegans)


name: MIB2 ubiquitinates CYLD at K338, K530 (Caenorhabditis elegans)


name: MIB2 ubiquitinates CFLAR  (Caenorhabditis elegans)


name: MIB2 binds CFLAR (Caenorhabditis elegans)


name: TNFR1-induced NF-kappa-B signaling pathway (Homo sapiens)


name: BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)


name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Homo sapiens)


name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)


name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)


name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)


name: TNFR1-induced NF-kappa-B signaling pathway (Mus musculus)


name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)


name: BIRC(cIAP1/2) ubiquitinates RIPK1 (Mus musculus)


name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Mus musculus)


name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Mus musculus)


name: TNFR1-induced NF-kappa-B signaling pathway (Rattus norvegicus)


name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Rattus norvegicus)


name: BIRC(cIAP1/2) ubiquitinates RIPK1 (Rattus norvegicus)


name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)


name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Rattus norvegicus)


name: TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)


name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)


name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Canis familiaris)


name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Canis familiaris)


name: BIRC(cIAP1/2) ubiquitinates RIPK1 (Canis familiaris)


name: TNFR1-induced NF-kappa-B signaling pathway (Bos taurus)


name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Bos taurus)


name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Bos taurus)


name: BIRC(cIAP1/2) ubiquitinates RIPK1 (Bos taurus)


name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Bos taurus)


name: TNFR1-induced NF-kappa-B signaling pathway (Sus scrofa)


name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Sus scrofa)


name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Sus scrofa)


name: BIRC(cIAP1/2) ubiquitinates RIPK1 (Sus scrofa)


name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Sus scrofa)


name: TNFR1-induced NF-kappa-B signaling pathway (Danio rerio)


name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Danio rerio)


name: BIRC(cIAP1/2) ubiquitinates RIPK1 (Danio rerio)


name: TNFR1-induced NF-kappa-B signaling pathway (Xenopus tropicalis)


name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Xenopus tropicalis)


name: BIRC(cIAP1/2) ubiquitinates RIPK1 (Xenopus tropicalis)


name: TNFR1-induced NF-kappa-B signaling pathway (Gallus gallus)


name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Gallus gallus)


name: BIRC(cIAP1/2) ubiquitinates RIPK1 (Gallus gallus)


name: TNFR1-mediated ceramide production (Homo sapiens)


name: TNF-α:TNFR1 binds NSMAF (Homo sapiens)


name: TNF-α:TNFR1:NSMAF binds GNB2L1 (Homo sapiens)


name: TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Homo sapiens)


name: TNFR1-mediated ceramide production (Mus musculus)


name: TNF-α:TNFR1 binds NSMAF (Mus musculus)


name: TNF-α:TNFR1:NSMAF binds GNB2L1 (Mus musculus)


name: TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Mus musculus)


name: TNFR1-mediated ceramide production (Rattus norvegicus)


name: TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Rattus norvegicus)


name: TNF-α:TNFR1:NSMAF binds GNB2L1 (Rattus norvegicus)


name: TNF-α:TNFR1 binds NSMAF (Rattus norvegicus)


name: TNFR1-mediated ceramide production (Canis familiaris)


name: TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Canis familiaris)


name: TNF-α:TNFR1:NSMAF binds GNB2L1 (Canis familiaris)


name: TNF-α:TNFR1 binds NSMAF (Canis familiaris)


name: TNFR1-mediated ceramide production (Bos taurus)


name: TNF-α:TNFR1:NSMAF binds GNB2L1 (Bos taurus)


name: TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Bos taurus)


name: TNF-α:TNFR1 binds NSMAF (Bos taurus)


name: TNFR1-mediated ceramide production (Sus scrofa)


name: TNF-α:TNFR1 binds NSMAF (Sus scrofa)


name: TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Sus scrofa)


name: TNF-α:TNFR1:NSMAF binds GNB2L1 (Sus scrofa)


name: TNFR1-mediated ceramide production (Danio rerio)


name: TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Danio rerio)


name: TNFR1-mediated ceramide production (Xenopus tropicalis)


name: TNF-α:TNFR1 binds NSMAF (Xenopus tropicalis)


name: TNF-α:TNFR1:NSMAF binds GNB2L1 (Xenopus tropicalis)


name: TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Xenopus tropicalis)


name: TNFR1-mediated ceramide production (Gallus gallus)


name: TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Gallus gallus)


name: TNFR1-induced proapoptotic signaling (Homo sapiens)


name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Homo sapiens)


name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8   (Homo sapiens)


name: TRADD:TRAF2:RIP1 complex binds FADD (Homo sapiens)


name: TNFR1-induced proapoptotic signaling (Mus musculus)


name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Mus musculus)


name: TRADD:TRAF2:RIP1 complex binds FADD (Mus musculus)


name: TNFR1-induced proapoptotic signaling (Rattus norvegicus)


name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Rattus norvegicus)


name: TRADD:TRAF2:RIP1 complex binds FADD (Rattus norvegicus)


name: TNFR1-induced proapoptotic signaling (Canis familiaris)


name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Canis familiaris)


name: TNFR1-induced proapoptotic signaling (Bos taurus)


name: TRADD:TRAF2:RIP1 complex binds FADD (Bos taurus)


name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Bos taurus)


name: TNFR1-induced proapoptotic signaling (Sus scrofa)


name: TRADD:TRAF2:RIP1 complex binds FADD (Sus scrofa)


name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Sus scrofa)


name: TNFR1-induced proapoptotic signaling (Xenopus tropicalis)


name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Xenopus tropicalis)


name: TNFR1-induced proapoptotic signaling (Gallus gallus)


name: TRADD:TRAF2:RIP1 complex binds FADD (Gallus gallus)


name: Soluble TNF-α binds TNFR1 (Mus musculus)


name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Mus musculus)


name: TNF-α is cleaved by ADAM17 (TACE) (Mus musculus)


name: TNF-alpha inhibitors bind to TNF(1-233) trimer (Mus musculus)


name: Membrane-anchored TNF-α binds TNFR1 (Mus musculus)


name: TNF-alpha inhibitors bind to soluble TNF trimer (Mus musculus)


name: RIPK1-mediated regulated necrosis (Mus musculus)


name: RIPK3 phosphorylates MLKL (Mus musculus)


name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Mus musculus)


name: RIPK1:RIPK3 oligomer binds MLKL (Mus musculus)


name: Caspase activation via Death Receptors in the presence of ligand (Mus musculus)


name: MyD88-independent TLR4 cascade  (Mus musculus)


name: SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Mus musculus)


name: TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Mus musculus)


name: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Mus musculus)


name: FasL:Fas binds FADD (Mus musculus)


name: Trimerization of the FASL:FAS receptor complex (Mus musculus)


name: TRAIL:TRAIL receptor trimers bind FADD (Mus musculus)


name: TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Mus musculus)


name: TRAIL binds TRAIL receptors (Mus musculus)


name: TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Mus musculus)


name: Trimerization of TRAIL:TRAIL receptor complex (Mus musculus)


name: TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Homo sapiens)


name: TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Homo sapiens)


name: TRAIL binds TRAIL receptors (Homo sapiens)


name: TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Homo sapiens)


name: TRAIL:TRAIL receptor trimers bind FADD (Homo sapiens)


name: Trimerization of TRAIL:TRAIL receptor complex (Homo sapiens)


name: TRAIL:TRAIL receptor trimers bind FADD (Rattus norvegicus)


name: Trimerization of TRAIL:TRAIL receptor complex (Rattus norvegicus)


name: TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Rattus norvegicus)


name: TRAIL binds TRAIL receptors (Rattus norvegicus)


name: TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Rattus norvegicus)


name: Caspase activation via Death Receptors in the presence of ligand (Rattus norvegicus)


name: MyD88-independent TLR4 cascade  (Rattus norvegicus)


name: TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Rattus norvegicus)


name: SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Rattus norvegicus)


name: RIPK1-mediated regulated necrosis (Rattus norvegicus)


name: RIPK1 is phosphorylated (Rattus norvegicus)


name: RIPK1:RIPK3 oligomer binds MLKL (Rattus norvegicus)


name: RIPK3 is phosphorylated (Rattus norvegicus)


name: RIPK3 phosphorylates MLKL (Rattus norvegicus)


name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Rattus norvegicus)


name: Caspase activation via Dependence Receptors in the absence of ligand (Rattus norvegicus)


name: Caspase-9 binds DCC:DIP13alpha complex (Rattus norvegicus)


name: Activation of caspase-3 (Rattus norvegicus)


name: DCC interacts with DIP13alpha (Rattus norvegicus)


name: Caspase cleavage of DCC (Rattus norvegicus)


name: Caspase activation via Dependence Receptors in the absence of ligand (Homo sapiens)


name: Caspase cleavage of UNC5A (Homo sapiens)


name: Caspase cleavage of UNC5B (Homo sapiens)


name: Caspase-9 binds DCC:DIP13alpha complex (Homo sapiens)


name: DCC interacts with DIP13alpha (Homo sapiens)


name: Caspase activation via Dependence Receptors in the absence of ligand (Mus musculus)


name: Caspase-9 binds DCC:DIP13alpha complex (Mus musculus)


name: DCC interacts with DIP13alpha (Mus musculus)


name: Caspase activation via Dependence Receptors in the absence of ligand (Canis familiaris)


name: Activation of caspase-3 (Canis familiaris)


name: Caspase-9 binds DCC:DIP13alpha complex (Canis familiaris)


name: DCC interacts with DIP13alpha (Canis familiaris)


name: Caspase cleavage of DCC (Canis familiaris)


name: Caspase activation via Dependence Receptors in the absence of ligand (Bos taurus)


name: Caspase-9 binds DCC:DIP13alpha complex (Bos taurus)


name: DCC interacts with DIP13alpha (Bos taurus)


name: Caspase activation via Dependence Receptors in the absence of ligand (Sus scrofa)


name: Caspase-9 binds DCC:DIP13alpha complex (Sus scrofa)


name: DCC interacts with DIP13alpha (Sus scrofa)


name: Caspase activation via Dependence Receptors in the absence of ligand (Danio rerio)


name: Caspase activation via Dependence Receptors in the absence of ligand (Xenopus tropicalis)


name: Caspase cleavage of DCC (Xenopus tropicalis)


name: Caspase activation via Dependence Receptors in the absence of ligand (Drosophila melanogaster)


name: Caspase cleavage of DCC (Drosophila melanogaster)


name: Caspase activation via Dependence Receptors in the absence of ligand (Caenorhabditis elegans)


name: Caspase cleavage of DCC (Caenorhabditis elegans)


name: FasL/ CD95L signaling (Rattus norvegicus)


name: Trimerization of the FASL:FAS receptor complex (Rattus norvegicus)


name: FasL:Fas binds FADD (Rattus norvegicus)


name: FASL binds FAS Receptor (Rattus norvegicus)


name: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Rattus norvegicus)


name: Membrane-anchored TNF-α binds TNFR1 (Rattus norvegicus)


name: Soluble TNF-α binds TNFR1 (Rattus norvegicus)


name: TNF-alpha inhibitors bind to soluble TNF trimer (Rattus norvegicus)


name: TNF-α is cleaved by ADAM17 (TACE) (Rattus norvegicus)


name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Rattus norvegicus)


name: TNF-alpha inhibitors bind to TNF(1-233) trimer (Rattus norvegicus)


name: Caspase activation via Death Receptors in the presence of ligand (Canis familiaris)


name: FasL/ CD95L signaling (Canis familiaris)


name: Trimerization of the FASL:FAS receptor complex (Canis familiaris)


name: FASL binds FAS Receptor (Canis familiaris)


name: TNF-alpha inhibitors bind to TNF(1-233) trimer (Canis familiaris)


name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Canis familiaris)


name: TNF-α is cleaved by ADAM17 (TACE) (Canis familiaris)


name: TNF-alpha inhibitors bind to soluble TNF trimer (Canis familiaris)


name: RIPK1-mediated regulated necrosis (Canis familiaris)


name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Canis familiaris)


name: RIPK3 is phosphorylated (Canis familiaris)


name: RIPK1 is phosphorylated (Canis familiaris)


name: FasL:Fas binds FADD (Bos taurus)


name: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Bos taurus)


name: Trimerization of the FASL:FAS receptor complex (Bos taurus)


name: Caspase activation via Death Receptors in the presence of ligand (Bos taurus)


name: MyD88-independent TLR4 cascade  (Bos taurus)


name: SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Bos taurus)


name: TNF-alpha inhibitors bind to soluble TNF trimer (Bos taurus)


name: TNF-α is cleaved by ADAM17 (TACE) (Bos taurus)


name: TNF-alpha inhibitors bind to TNF(1-233) trimer (Bos taurus)


name: Membrane-anchored TNF-α binds TNFR1 (Bos taurus)


name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Bos taurus)


name: RIPK1-mediated regulated necrosis (Bos taurus)


name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Bos taurus)


name: RIPK1:RIPK3 oligomer binds MLKL (Bos taurus)


name: TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Sus scrofa)


name: Caspase activation via Death Receptors in the presence of ligand (Sus scrofa)


name: MyD88-independent TLR4 cascade  (Sus scrofa)


name: TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Sus scrofa)


name: RIPK1-mediated regulated necrosis (Sus scrofa)


name: RIPK1:RIPK3 oligomer binds MLKL (Sus scrofa)


name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Sus scrofa)


name: FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Sus scrofa)


name: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Sus scrofa)


name: FasL:Fas binds FADD (Sus scrofa)


name: Trimerization of the FASL:FAS receptor complex (Sus scrofa)


name: TNF-alpha inhibitors bind to TNF(1-233) trimer (Sus scrofa)


name: TNF-α is cleaved by ADAM17 (TACE) (Sus scrofa)


name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Sus scrofa)


name: TNF-alpha inhibitors bind to soluble TNF trimer (Sus scrofa)


name: Membrane-anchored TNF-α binds TNFR1 (Sus scrofa)


name: TNF-alpha inhibitors bind to TNF(1-233) trimer (Danio rerio)


name: TNF-alpha inhibitors bind to soluble TNF trimer (Danio rerio)


name: TNF-alpha inhibitors bind to soluble TNF trimer (Xenopus tropicalis)


name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Xenopus tropicalis)


name: TNF-α is cleaved by ADAM17 (TACE) (Xenopus tropicalis)


name: TNF-alpha inhibitors bind to TNF(1-233) trimer (Xenopus tropicalis)


name: FasL/ CD95L signaling (Xenopus tropicalis)


name: Trimerization of the FASL:FAS receptor complex (Xenopus tropicalis)


name: FASL binds FAS Receptor (Xenopus tropicalis)


name: FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Gallus gallus)


name: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Gallus gallus)


name: FasL:Fas binds FADD (Gallus gallus)


name: Trimerization of the FASL:FAS receptor complex (Gallus gallus)


name: Caspase activation via Death Receptors in the presence of ligand (Gallus gallus)


name: MyD88-independent TLR4 cascade  (Gallus gallus)


name: TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Gallus gallus)


name: TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Gallus gallus)


name: TRAIL binds TRAIL receptors (Gallus gallus)


name: TRAIL:TRAIL receptor trimers bind FADD (Gallus gallus)


name: TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Gallus gallus)


name: TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Gallus gallus)


name: Trimerization of TRAIL:TRAIL receptor complex (Gallus gallus)


name: HMGB1 release from cells (Caenorhabditis elegans)


name: Regulation of TLR by endogenous ligand (Caenorhabditis elegans)


name: HMGB1 binds LTP (Caenorhabditis elegans)


name: HMGB1 binds LPS (Caenorhabditis elegans)


name: RAF/MAP kinase cascade (Caenorhabditis elegans)


name: RAS:GTP binds RAL GDS proteins (Caenorhabditis elegans)


name: RAS:GTP binds PI3K (Caenorhabditis elegans)