name: Acute Myeloid Leukemia with Complex Karyotype

description: Acute myeloid leukemia associated with at least 3 unrelated clonal chromosomal abnormalities.


A polyketide obtainbed by allylic hydroxylation of dihydromonacolin L acid at the 3alpha-position.


A pentol that is 12,16-dimethylicosan-2-one in which the five hydroxy substituents are located at positions 3, 5, 10, 14 and 15.


A steroid glucosiduronic acid that is 2-hydroxyestrone having a single beta-D-glucuronic acid residue attached at position 3.


name: 5'-end (N(7)-methyl 5'-triphospho-guanosine)-guanosine-ribonucleotide(3-) residue

description: A 7-methyl guanosine (m7G) linked via an inverted 5'-5' triphosphate bridge to an initiating guanosine ribonucleotide followed by any ribonucleotide; major species at pH 7.3.


glucuronamide

A monosaccharide derivative that is the carboxamide of beta-D-glucuronic acid


name: Childhood Neuroblastoma by Toronto Guidelines v2 Stage

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A term that refers to the staging of childhood neuroblastoma according to the Toronto childhood cancer staging guidelines v2.


name: Familial Adenomatous Polyposis Associated Medulloblastoma

description: A medulloblastoma developing in patients with familiar adenomatous polyposis syndrome.  It is observed in patients with Turcot syndrome, type 2.


Medulloblastoma, SHH-4

description: Medulloblastoma, SHH-activated, characterized by mutations of U1-snRNA and TERT genes. Mutations of PTCH1 or SMO genes are usually also present. It affects mostly adults.


Sellar Neuroblastoma

description: A rare neuroblastoma arising from the sella turcica.


Refractory Ganglioneuroblastoma

description: Ganglioneuroblastoma that does not respond to treatment.


name: Embryonal Tumor with Multilayered Rosettes, DICER1-Mutated

description: An embryonal tumor with multilayered rosettes characterized by the presence of DICER1 mutation. Approximately half of embryonal tumors with multilayered rosettes that lack a C19MC alteration carry DICER1 mutations.


Refractory Dedifferentiated Chordoma

description: A dedifferentiated chordoma that does not respond to treatment.


Childhood Brain Neuroblastoma

description: A neuroblastoma that arises from the brain during childhood.


Refractory Rhabdoid Tumor

description: Rhabdoid tumor that does not respond to treatment.


name: Stage M1 Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2

description: Tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Hereditary Neuroblastoma

description: Genetic inheritance of neuroblastoma caused by mutations in the ALK or PHOX2B genes.  Familial neuroblastomas have a higher incidence of multiple primary tumors and are diagnosed at an earlier age.


name: Childhood Central Nervous System Ganglioneuroblastoma

description: A central nervous system ganglioneuroblastoma that occurs during childhood.


name: Stage L1 Childhood Neuroblastoma by Toronto Guidelines v2

description: Localized tumor that does not involve any vital structures as defined by the list of IDRFs (i.e., there are no IDRFs) and the tumor must be confined within one body compartment, neck, chest, abdomen, or pelvis. An intraspinal tumor extension that does not fulfill the criteria for an IDRF is consistent with stage L1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Advanced Chordoma

description: A chordoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Central Nervous System Embryonal Tumor, Not Otherwise Specified with Leptomeningeal Spread

description: A central nervous system embryonal tumor, not otherwise specified which has spread from its original site to the leptomeninges surrounding the brain and spinal cord.


Visual Pathway Medulloepithelioma

description: A very rare, benign or malignant embryonal neoplasm affecting the visual pathway during childhood. It arises from primitive medullary epithelium.


name: Embryonal Tumor with Multilayered Rosettes of the Fourth Ventricle

description: An embryonal tumor with multilayered rosettes that arises from the fourth ventricle.


Stage M4 Medulloblastoma

description: Metastasis outside the cerebrospinal axis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


name: Stage M3 Childhood Medulloblastoma by Toronto Guidelines v2

description: Visible metastasis in spine or visible metastasis in cervicomedullary junction. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Atypical Teratoid/Rhabdoid Tumor-TYR

description: Atypical teratoid/rhabdoid tumor characterized by overexpression of melanosomal genes (TYR, TYRP, MITF, and OTX2).


name: Stage M3 Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2


name: Neuroblastoma of the Adrenal Gland and Sympathetic Nervous System

description: A common pediatric extracranial tumor arising from neural crest cells.  It involves the adrenal medulla and the sympathetic nervous system.


name: Adult Supratentorial Embryonal Tumor, Not Otherwise Specified

description: A supratentorial embryonal tumor, not otherwise specified that occurs in adults.


Anaplastic Medulloblastoma

description: A medulloblastoma characterized by marked nuclear pleomorphism, and high mitotic activity.


Paratesticular Wilms Tumor

description: A rare Wilms tumor that arises from the paratesticular structures.


name: Childhood Neuroblastoma by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood neuroblastoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


Atypical Teratoid/Rhabdoid Tumor-SHH

description: Atypical teratoid/rhabdoid tumor characterized by overexpression of genes in the sonic hedgehog (SHH) pathway (GLI2, BOC, PTCHD2, and MYCN).


Prostate Wilms Tumor

description: A rare Wilms tumor affecting the prostate gland.


name: Childhood Atypical Teratoid/Rhabdoid Tumor

description: An atypical teratoid/rhabdoid tumor occurring in children.


name: Stage M0 Childhood Medulloblastoma by Toronto Guidelines v2

description: No visible disease on imaging (MRI brain and spine) beyond primary site of disease and no tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Localized Childhood Neuroblastoma by Toronto Guidelines v2

description: Localized tumor not involving vital structures and confined to one body compartment. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


description: An intermixed ganglioneuroblastoma that occurs during childhood.


name: Pineoblastoma miRNA Processing Altered 1

description: Pineoblastoma characterized by alterations in genes involved in miRNA biogenesis (DICER1, DROSHA, and DGCR8). It may manifest as a sporadic tumor or part of DICER1 syndrome. It affects children.


Localized Resectable Neuroblastoma

description: Neuroblastoma that is confined to a specific site and is amenable to surgical removal.


name: Refractory Peripheral Primitive Neuroectodermal Tumor

description: Peripheral primitive neuroectodermal tumor that does not respond to treatment.


Recurrent Rhabdoid Tumor

description: The reemergence of rhabdoid tumor after a period of remission.


Thyroblastoma

description: A high-grade, rapidly growing malignant embryonal neoplasm that arises from the thyroid gland. It is characterized by the presence of primitive follicular-like structures surrounded by primitive small cells and primitive spindle cell mesenchymal stroma. It is associated with DICER1 gene mutations. The prognosis is poor.


Extra-osseous Ewing's sarcoma recurrent

description: Reemergence of extraskeletal Ewing sarcoma after a period of remission.


name: Peripheral neuroepithelioma of bone metastatic

description: A small round cell tumor of the bone with neural differentiation that has spread from its original site of growth to another anatomic site.


Unresectable Ewing Sarcoma

description: A Ewing sarcoma which is not amenable to surgical resection.


name: Stage M4 Embryonal Tumor with Multilayered Rosettes

description: Metastasis outside the cerebrospinal axis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


name: Central Nervous System Embryonal Neoplasm

description: A malignant neoplasm of embryonal origin, arising from the central nervous system.  It usually affects children.  Representative examples include ependymoblastoma, medulloblastoma, and atypical teratoid/rhabdoid tumor.


Locally Advanced Ewing Sarcoma

description: Ewing sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Locally Advanced Olfactory Neuroblastoma

description: Olfactory neuroblastoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Childhood Medulloblastoma by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood medulloblastoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


Stage M1 Pineoblastoma

description: Microscopic tumor cells are detected in the cerebrospinal fluid. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Sellar Dedifferentiated Chordoma

description: A dedifferentiated chordoma that arises from the sellar region.


name: Stage M2 Atypical Teratoid/Rhabdoid Tumor

description: Gross nodular seeding is detected in the cerebellar/cerebral subarachnoid space or in the third or lateral ventricles. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


name: Stage M0 Atypical Teratoid/Rhabdoid Tumor

description: No evidence of subarachnoid or hematogenous metastasis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


name: Recurrent Childhood Central Nervous System Embryonal Neoplasm

description: The reemergence of childhood central nervous system embryonal neoplasm after a period of remission.


Resectable Neuroblastoma

description: Neuroblastoma that is amenable to surgical resection.


Childhood Brain Ganglioneuroblastoma

description: A ganglioneuroblastoma that arises from the brain and occurs during childhood.


name: Stage L2 Childhood Neuroblastoma by Toronto Guidelines v2

description: Locoregional tumor with one or more IDRFs. The tumor may be ipsilateral contiguous within body compartments (i.e., a left-sided abdominal tumor with left-sided lung, bone or pleura involvement should be considered stage L2). However, a clearly left-sided abdominal tumor with right-sided lung, bone or pleura (or vice-versa) involvement is defined as metastatic disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Childhood Neuroblastoma by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood neuroblastoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


High Risk Neuroblastoma

description: Neuroblastoma usually presenting with metastatic disease and MYCN gene amplifications.


name: embryonal tumor with multilayered rosettes

description: A central nervous system embryonal tumor characterized by the presence of multilayered rosette formation and typically the presence of amplification of the C19MC region on chromosome 19 (19q13.42) or rarely a DICER1 mutation.


name: Peripheral neuroepithelioma of bone recurrent

description: The reemergence of peripheral primitive neuroectodermal tumor of the bone after a period of remission.


Cribriform Neuroepithelial Tumor

description: A very rare, nonrhabdoid, intraventricular tumor with relatively favorable prognosis.  It is characterized by the presence of neuroepithelial cells forming cribriform patterns, trabeculae, epithelial membrane antigen immunopositivity on epithelial surfaces, and loss of nuclear INI 1 expression.


Sellar Chordoma

description: A chordoma that arises from the sellar region.


description: The reemergence of medulloblastoma, WNT-activated after a period of remission.


Stage 3 Neuroblastoma

description: Unresectable unilateral tumor infiltrating across the midline, with or without regional lymph node involvement; or localized unilateral tumor with contralateral regional lymph node involvement; or midline tumor with bilateral extension by infiltration (unresectable) or by lymph node involvement. The midline is defined as the vertebral column. Tumors originating on one side and crossing the midline must infiltrate to or beyond the opposite side of the vertebral column. (cancer.gov)


name: Refractory Atypical Teratoid/Rhabdoid Tumor

description: An atypical teratoid/rhabdoid tumor that does not respond to treatment.


Stage 4S neuroblastoma

description: Localized primary tumor, as defined for stage 1, 2A, or 2B, with dissemination limited to skin, liver, and/or bone marrow (limited to infants younger than 1 year). Marrow involvement should be minimal (i.e., <10% of total nucleated cells identified as malignant by bone biopsy or by bone marrow aspirate). More extensive bone marrow involvement would be considered stage 4 disease. The results of the MIBG scan, if performed, should be negative for disease in the bone marrow. (cancer.gov)


name: Metastatic Childhood Neuroblastoma by Toronto Guidelines v2

description: Distant metastatic disease (except stage MS). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood central nervous system embryonal tumor according to the tier 2 Toronto childhood cancer staging guidelines v2.


name: Localized Childhood Medulloblastoma by Toronto Guidelines v2

description: Localized disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Medulloblastoma with Leptomeningeal Spread

description: A medulloblastoma which has spread from its original site to the leptomeninges surrounding the brain and spinal cord.


Unresectable Rhabdoid Tumor

description: A rhabdoid tumor that is not amenable to surgical resection.


Stage IV Kidney Wilms Tumor

description: Wilms tumor that has spread to other more distant organs, such as the lungs, liver, bones, and brain, or to lymph nodes outside the abdomen (National Wilms Tumor Study Group Staging System)


Poorly Differentiated Neuroblastoma

description: A neuroblastoma in which the differentiating neuroblasts constitute less than five-percent of the tumor cells.


Childhood Ewing Sarcoma

description: A Ewing sarcoma that occurs during childhood.


Skin Ewing Sarcoma

description: A rare Ewing sarcoma that arises from the skin.


name: Recurrent Atypical Teratoid/Rhabdoid Tumor

description: The reemergence of an atypical teratoid/rhabdoid tumor after a period of remission.


name: Stage M0 Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2

description: No visible disease on imaging (MRI brain and spine) beyond primary site of disease and no tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Atypical Teratoid/Rhabdoid Tumor Molecular Subtypes

description: A term that refers to the classification of atypical teratoid/rhabdoid tumors according to their molecular characteristics.


Unresectable Chordoma

description: A chordoma which is not amenable to surgical resection.


Pineoblastoma, MYC/FOXR2-Activated

description: Pineoblastoma characterized by MYC activation, chromosome 16 losses, and overexpression of FOXR2. It affects young children and is associated with a dismal prognosis.


Locally Advanced Neuroblastoma

description: A neuroblastoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Undifferentiated Neuroblastoma

description: A neuroblastoma characterized by the absence of differentiating neuroblasts.


name: Childhood Medulloblastoma by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood medulloblastoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


Stage 2 Neuroblastoma

description: Stage 2 includes stage 2A and stage 2B.  Stage 2A: Localized tumor with incomplete gross excision; representative ipsilateral nonadherent lymph nodes negative for tumor microscopically. Stage 2B: Localized tumor with or without complete gross excision, with ipsilateral nonadherent lymph nodes positive for tumor. Enlarged contralateral lymph nodes must be negative microscopically. (cancer.gov)


Locally Advanced Chordoma

description: A chordoma that has spread from its original site of growth to nearby tissues.


Regional Neuroblastoma

description: A neuroblastoma confined to a specific anatomic region without evidence of dissemination.


Stage M2 Medulloblastoma

description: Gross nodular seeding is detected in the cerebellar/cerebral subarachnoid space or in the third or lateral ventricles. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


name: Ciliary Body Teratoid Medulloepithelioma

description: A rare, unilateral, benign or malignant embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium and contains heterologous elements, particularly cartilage, skeletal muscle, and brain tissue.


Metastatic Olfactory Neuroblastoma

description: Olfactory neuroblastoma that has spread from its original site of growth to other anatomic sites.


name: Pineoblastoma miRNA Processing Altered 2

description: Pineoblastoma characterized by alterations in genes involved in miRNA biogenesis (DICER1, DROSHA, and DGCR8). It may manifest as a sporadic tumor or part of DICER1 syndrome. It affects older children and follows a more favorable course.


name: Extrarenal Rhabdoid Tumor of the Prostate

description: A rare extrarenal rhabdoid tumor affecting the prostate gland.


name: Stage M4 Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2

description: Metastasis outside of the central nervous system. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

description: A malignant small round cell tumor with or without neural differentiation that is resistant to treatment.


Neuroblastoma recurrent

description: The reemergence of neuroblastoma after a period of remission.


Unresectable Neuroblastoma

description: Neuroblastoma which is not amenable to surgical resection.


Stage 2A Neuroblastoma

description: Localized tumor with incomplete gross excision; representative ipsilateral nonadherent lymph nodes negative for tumor microscopically. (cancer.gov)


name: Sinonasal Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

description: A Ewing sarcoma that arises from the nasal cavity and paranasal sinuses.


Medulloblastoma Molecular Subtypes

description: A term that refers to the classification of medulloblastomas according to their molecular characteristics.


Metastatic Neuroblastoma

description: A neuroblastoma that has metastasized from its original site of growth to another anatomic site.


Recurrent Childhood Medulloblastoma

description: The reemergence of childhood medulloblastoma after a period of remission.


name: Localized Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2

description: Localized disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified

description: A supratentorial embryonal tumor, not otherwise specified that occurs in childhood.


name: Extra-osseous Ewing's sarcoma non-metastatic

description: Ewing sarcoma that arises from the soft tissue and is confined to a specific site without evidence of spread to other anatomic sites.


name: Medulloblastoma, Not Otherwise Specified

description: A medulloblastoma which has not been further characterized.


name: MS Childhood Neuroblastoma by Toronto Guidelines v2

description: Metastatic disease confined to skin, liver, and/or bone marrow in a patient less than 18 months (547 days). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage MS Childhood Neuroblastoma by Toronto Guidelines v2

description: Metastatic disease confined to skin, liver, and/or bone marrow, in a patient less than 18 months (547 days). MIBG scintigraphy must be negative in bone and bone marrow. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Benign medulloepithelioma of ciliary body

description: A rare, unilateral, benign embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium.


Recurrent tumors of the Ewing's family

description: The reemergence of a malignant small round cell tumor with or without neural differentiation after a period of remission.


name: Malignant medulloepithelioma of ciliary body

description: A rare, unilateral, malignant embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium.


name: Recurrent Primitive Neuroectodermal Tumor

description: The reemergence of a primitive neuroectodermal tumor of the central or the peripheral nervous system after a period of remission.


Anaplastic Kidney Wilms Tumor

description: Wilms tumor of the kidney characterized by the presence of nuclear anaplasia.  Anaplasia is defined by the presence of all of the following: multipolar polyploid mitotic figures, marked nuclear enlargement, and hyperchromasia.  When anaplasia is diffuse, it is associated with an unfavorable clinical outcome.


Disseminated neuroblastoma

description: Any primary tumor with dissemination to distant lymph nodes, bone, bone marrow, liver, skin, and/or other organs, except as defined for stage 4S. (cancer.gov)


Stage II Kidney Wilms Tumor

description: Wilms tumor that is found in the kidney and in the fat, soft tissue, or blood vessels near the kidney. It may have spread to the renal sinus. The renal sinus is the part of the kidney where blood and fluid enter and exit the organ. The tumor can be completely removed with surgery. (National Wilms Tumor Study Group Staging System)


Localized Askin Tumor

description: A small round cell tumor confined to a specific area of the thoracic cavity without evidence of spread to other anatomic sites.


Recurrent Medulloblastoma

description: The reemergence of medulloblastoma after a period of remission.


Recurrent Kidney Wilms Tumor

description: The reemergence of Wilms tumor of the kidney after a period of remission.


name: Stage M4 Atypical Teratoid/Rhabdoid Tumor

description: Metastasis outside the cerebrospinal axis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Stage III Kidney Wilms Tumor

description: Wilms tumor that is found in areas near the kidney and cannot be completely removed with surgery. The tumor may have spread to nearby organs and blood vessels or throughout the abdomen and to nearby lymph nodes. Lymph nodes are tiny, bean-shaped organs that help fight infection. Stage III cancer has not spread outside the abdomen. (National Wilms Tumor Study Group Staging System)


name: Central Nervous System Embryonal Tumor with Rhabdoid Features

description: A central nervous system embryonal neoplasm characterized by the presence of histological features consistent with atypical teratoid/rhabdoid tumor and absence of mutations of the INI1 gene or SMARCA4 (BRG1) gene.


name: Central Nervous System Embryonal Tumor, Not Elsewhere Classified

description: A central nervous system embryonal tumor lacking molecular abnormalities that would classify it as one of the molecularly defined central nervous system embryonal neoplasms.


Stage M0 Medulloblastoma

description: No evidence of subarachnoid or hematogenous metastasis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Atypical Teratoid/Rhabdoid Tumor-MYC

description: Atypical teratoid/rhabdoid tumor characterized by overexpression of MYC gene.


Refractory Wilms Tumor

description: Wilms tumor that is resistant to treatment.


name: Metastatic Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2

description: Disease beyond local site (e.g., other lesions in brain or spine or tumor cells in CSF or distant metastases). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Ganglioneuroblastoma, Nodular

description: A nodular ganglioneuroblastoma that occurs during childhood.


Unresectable Extrarenal Rhabdoid Tumor

description: Extrarenal rhabdoid tumor that is not amenable to surgical resection.


Stage M3 Medulloblastoma

description: Gross nodular seeding is detected in the spinal subarachnoid space. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Kadish Stage B Olfactory Neuroblastoma

description: An olfactory neuroblastoma that involves the nasal cavity and paranasal sinuses.


Fourth Ventricle Medulloblastoma

description: A medulloblastoma occurring in the fourth ventricle.


Localized Unresectable Neuroblastoma

description: Neuroblastoma that is confined to a specific site and is not amenable to surgical removal.


name: Stage M1 Childhood Medulloblastoma by Toronto Guidelines v2

description: Tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Pineoblastoma Molecular Subtypes

description: A term that refers to the classification of pineoblastomas according to their molecular characteristics.


Kidney Ewing Sarcoma

description: A rare Ewing sarcoma arising from the kidney.


Kadish Stage A Olfactory Neuroblastoma

description: An olfactory neuroblastoma that is confined to the nasal cavity


name: Stage M3 Embryonal Tumor with Multilayered Rosettes


name: Metastatic Childhood Medulloblastoma by Toronto Guidelines v2


Benign Notochordal Cell Tumor

description: An intraosseous benign tumor of notochord origin that arises in the bones of the base of the skull, vertebral bodies, sacrum or coccyx.  It contains vacuolated tumor cells without atypia, but lacks myxoid matrix, necrosis, and lobular architecture, which are features that characterize its malignant counterpart, chordoma.  Most lesions are incidental findings.


Recurrent Extrarenal Rhabdoid Tumor

description: The reemergence of extrarenal rhabdoid tumor after a period of remission.


name: Central Nervous System Neuroblastoma, FOXR2-Activated

description: A rare central nervous system neoplasm with neuroblastic and/or neuronal differentiation. It is characterized by the presence of structural rearrangements of FOXR2 gene that result in the activation of the transcription factor FOXR2.


name: Refractory Primitive Neuroectodermal Tumor

description: Primitive neuroectodermal tumor that does not respond to treatment.


Metastatic Medulloblastoma

description: Medulloblastoma that has spread from its original site of growth to another anatomic site.


Stage 1 Neuroblastoma

description: Localized tumor with complete gross excision, with or without microscopic residual disease; representative ipsilateral lymph nodes negative for tumor microscopically. (cancer.gov)


Vulvar Ewing Sarcoma

description: Ewing sarcoma arising from the vulva.


Central Nervous System Ewing Sarcoma

description: Ewing sarcoma that arises in the central nervous system.


name: Region 17p13 Allelic Loss Associated Medulloblastoma

description: A medulloblastoma characterized by the loss of one of the p13 regions of chromosome 17.  Loss of genetic material of chromosome arm 17p is the most common molecular genetic abnormality found in medulloblastomas.


Stage M0 Pineoblastoma

description: No evidence of subarachnoid or hematogenous metastasis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Recurrent Bone Ewing Sarcoma

description: The reemergence of Ewing sarcoma of the bone after a period of remission.


Stage M2 Pineoblastoma

description: Gross nodular seeding is detected in the cerebellar/cerebral subarachnoid space or in the third or lateral ventricles. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


name: Stage M2 Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2

description: Visible metastasis in brain. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Extra-osseous Ewing's sarcoma metastatic

description: An Ewing sarcoma of the soft tissues which has spread from its original site of growth to another anatomic site.


Sinonasal Olfactory Neuroblastoma

description: An olfactory neuroblastoma that arises from the sinonasal tract.


Childhood Chordoma

description: A rare chordoma that occurs during childhood.


Childhood Kidney Ewing Sarcoma

description: An extremely rare Ewing sarcoma that arises from the kidney during childhood.


Childhood Pineoblastoma

description: A pineoblastoma that occurs during childhood.


Metastatic Chordoma

description: A chordoma that has spread from its original site of growth to other anatomic sites.


name: Stage M Childhood Neuroblastoma by Toronto Guidelines v2

description: Distant metastatic disease (i.e., not contiguous with the primary tumor) except as defined for stage MS. Nonregional (distant) lymph node involvement is metastatic disease. However, an upper abdominal tumor with enlarged lower mediastinal nodes or a pelvic tumor with inguinal lymph node involvement is considered locoregional disease. Ascites and/or a pleural effusion, even with malignant cells, do not constitute metastatic disease unless they are remote from the body compartment of the primary tumor. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Medulloblastoma, SHH-1

description: Medulloblastoma, SHH-activated, characterized by SUFU gene mutations and chromosome 2 gain. It affects mostly infants.


Stage I Kidney Wilms Tumor

description: Wilms tumor that is found in one kidney and can be completely removed with surgery. (National Wilms Tumor Study Group Staging System)


Dedifferentiated chordoma

description: A high-grade malignant bone tumor arising from the remnants of the notochord. It is characterized by a lobulated growth pattern, myxoid stroma formation, the presence of physaliphorous cells, and a sarcomatous component.


Recurrent Ganglioneuroblastoma

description: The reemergence of ganglioneuroblastoma after a period of remission.


description: The reemergence of SHH-activated medulloblastoma after a period of remission.


name: Childhood Central Nervous System Embryonal Neoplasm

description: A central nervous system embryonal tumor that occurs during childhood.


name: Peripheral Primitive Neuroectodermal Tumor of the Kidney

description: A small round cell tumor with neural differentiation arising from the kidney.


Recurrent Olfactory Neuroblastoma

description: The reemergence of olfactory neuroblastoma after a period of remission.


Head and Neck Ewing Sarcoma

description: A Ewing sarcoma that arises from the head and neck region. The most frequent sites of involvement are the skull and facial bones, head and neck soft tissue, and mandible.


Childhood Ganglioneuroblastoma

description: A ganglioneuroblastoma that occurs during childhood.


Large cell Ewing sarcoma of bone

description: Ewing sarcoma characterized by the presence of large malignant cells with prominent nucleoli and irregular contours.


Medulloblastoma, SHH-3

description: Medulloblastoma, SHH-activated, characterized by mutations of TP53 and ELP1 genes. It affects older individuals.


name: Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood central nervous system embryonal tumor according to the tier 1 Toronto childhood cancer staging guidelines v2.


name: Recurrent Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified

description: The reemergence of supratentorial embryonal tumor, not otherwise specified in childhood after a period of remission.


Stage M4 Pineoblastoma

description: Metastasis outside the cerebrospinal axis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


PNET of bone localised

description: A small round cell tumor with neural differentiation that is confined to a specific area of the bone and has not spread to other anatomic sites.


name: Embryonal Tumor with Multilayered Rosettes without C19MC Alteration

description: An embryonal tumor with multilayered rosettes characterized by the absence of C19MC amplification. Approximately half of embryonal tumors with multilayered rosettes that lack a C19MC alteration carry DICER1 mutations.


Kadish Stage C Olfactory Neuroblastoma

description: An olfactory neuroblastoma that extends beyond the nasal cavity and paranasal sinuses.


name: Nevoid Basal Cell Carcinoma Syndrome Associated Medulloblastoma

description: A medulloblastoma developing in patients with multiple basal cell carcinomas.  It is observed in patients with nevoid basal cell carcinoma syndrome and it is associated with PTCH gene inactivation.


description: Medulloblastoma, WNT-activated that is resistant to treatment.


Refractory Medulloblastoma

description: Medulloblastoma that does not respond to treatment.


name: Stage M2 Childhood Medulloblastoma by Toronto Guidelines v2

description: Visible metastasis in brain. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage M0 Embryonal Tumor with Multilayered Rosettes

description: No evidence of subarachnoid or hematogenous metastasis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


name: Stage M4 Childhood Medulloblastoma by Toronto Guidelines v2

description: Metastasis outside of the central nervous system. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage 2B Neuroblastoma

description: Localized tumor with or without complete gross excision, with ipsilateral nonadherent lymph nodes positive for tumor. Enlarged contralateral lymph nodes must be negative microscopically. (cancer.gov)


name: Childhood Central Nervous System Neuroblastoma

description: A neuroblastoma that arises from the central nervous system and occurs during childhood.


description: SHH-activated medulloblastoma that does not respond to treatment.


Metastatic Bone Ewing Sarcoma

description: An Ewing sarcoma of the bone which has spread from its original site of growth to another anatomic site.


name: Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

description: A small round cell tumor with or without neural differentiation that has spread from its original site of growth to another anatomic site.


Stage M1 Medulloblastoma

description: Microscopic tumor cells are detected in the cerebrospinal fluid. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Metastatic Ewing's Sarcoma

description: Ewing sarcoma that has spread from its original site of growth to another anatomic site.


Refractory Ewing Sarcoma

description: Ewing sarcoma that does not respond to treatment.


name: Recurrent Peripheral Primitive Neuroectodermal Tumor

description: The reemergence of a small round cell tumor with neural differentiation after a period of remission.


ELP1-Associated Medulloblastoma

description: An SHH-activated, TP53-wildtype medulloblastoma caused by germline ELP1 gene variations and develops during childhood.


name: Stage M1 Atypical Teratoid/Rhabdoid Tumor


name: Locoregional Childhood Neuroblastoma by Toronto Guidelines v2

description: Locoregional tumor with spread. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Mesoblastic nephroma, mixed

description: A congenital mesoblastic nephroma characterized by the presence of classic and cellular areas.


Refractory Chordoma

description: A chordoma that does not respond to treatment.


name: Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood central nervous system embryonal tumor according to the Toronto childhood cancer staging guidelines v2.


name: Central Nervous System Ganglioneuroblastoma

description: A malignant central nervous system neoplasm characterized by the presence of poorly differentiated or undifferentiated neuroepithelial cells and ganglion cells.


Childhood Neuroblastoma

description: A neuroblastoma that occurs during childhood.


Ewing's sarcoma recurrent

description: Ewing sarcoma which has recurred after treatment and/or remission. While initial complete responses are not uncommon, there is a fair chance of relapse as late as one to two decades after initial therapy.


name: Stage M2 Embryonal Tumor with Multilayered Rosettes

description: Gross nodular seeding is detected in the cerebellar/cerebral subarachnoid space or in the third or lateral ventricles. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


name: Stage M3 Atypical Teratoid/Rhabdoid Tumor

description: Gross nodular seeding is detected in the spinal subarachnoid space. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


name: Childhood Medulloblastoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood medulloblastoma according to the Toronto childhood cancer staging guidelines v2.


Pineoblastoma, RB1-Altered

description: Pineoblastoma characterized by alterations in RB1 gene. It may develop in the setting of congenital retinoblastoma, also known as trilateral retinoblastoma. It affects young children and is associated with a dismal prognosis.


compound 78

GlcA-GlcNS6S-IdoA2S-GlcNS6S3S-IdoA2S-GlcNS6S


ethyl dihydrogen phosphate

A monoalkyl phosphate epitope having ethyl as the alkyl group.


A 3beta-sterol having double bonds in the 5- and 7-positions and a methylene group at position 24.


(S)-fenarimol

A (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol that has S configuration.


Acute cholecystitis without calculus

description: Acute inflammation of the gallbladder in the absence of gallstones


name: Calculus of gallbladder with cholecystitis

description: An acute or chronic inflammation of the gallbladder associated with the presence of gallstones.


Chronic acalculous cholecystitis

description: Chronic cholecystitis not associated with the presence of gallstones.


name: 5-nitro-2-furancarboxylic acid (5-phenyl-1,3,4-oxadiazol-2-yl)methyl ester


name: Intracranial Mesenchymal Tumor, FET-CREB Fusion-Positive

description: A provisional entity that refers to a group of neoplasms with a broad morphological spectrum, characterized by fusion of a FET family gene (usually EWSR1 and rarely FUS) with a member of the CREB family of transcription factors (CREB1, ATF1, or CREM). It includes entities previously termed intracranial angiomatoid fibrous histiocytoma or intracranial myxoid mesenchymal tumor. It is usually located in the supratentorial brain and mostly affects children and young adults. There is a spectrum of clinical behaviors ranging from slowly growing tumors to rapid recurrences, and rarely metastases.


A glycotriaosylceramide having alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl as the glycotriaosyl component attached to the Cer(d18:1/20:0).


(3R,11R)-3,11-dihydroxylauric acid

An (omega-1)-hydroxy fatty acid that is (11R)-11-hydroxylauric acid in which the 3-pro-R hydrogen is replaced by a hydroxy group.


capsaicinoid

A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.


A capsaicinoid that is a dimer obtained by replacement of the hydrogen at position 5' of capsaicin with 6'',7''-dihydrocapsaicin. It is isolated from the dried fruits of Capsicum annuum and exhibits antioxidant activity.


NONIVAMIDE

A capsaicinoid that is the carboxamide resulting from the formal condensation of the amino group of 4-hydroxy-3-methoxybenzylamine with the carboxy group of nonanoic acid. It is the active ingredient in many pepper sprays.


Val-Asp

A dipeptide formed from L-valine and L-aspartic acid residues.


A nucleotide residue derived from 5-aminomethyl-2-thiouridine 5'-monophosphate.


2-hydroxytridecanoic acid

A 2-hydroxy fatty acid that is tridecanoic acid substituted by  a hydroxy group at position 2.


Diffuse Low Grade Glioma, FGFR1-Mutant

description: Diffuse low-grade glioma characterized by FGFR1 gene mutations, an internal tandem duplication within the FGFR1 gene or the presence of an FGFR1 fusion gene.


An unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoic acid.


2-hydroxy-5-methyl-cis,cis-muconic acid

A dicarboxylic acid that is cis,cis-muconic acid in which the hydrogens at positions 2 and 5 are substituted by hydroxy and methyl groups, respectively.


Stage IV Rectosigmoid Cancer AJCC v7

description: Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b).  M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node).  M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


alliin zwitterion

An L-alpha-amino acid zwitterion that is allin in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3.


Astler-Coller B1 Rectal Carcinoma

description: Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. (AJCC 6th ed.)


Postprocedural respiratory disorders

description: A respiratory disorder occurring as a consequence of a procedure.


beta-L-gulofuranose

An L-gulofuranose in which the anomeric centre has beta- configuration.


An L-alpha-amino acid zwitterion that results from the transfer of a proton from the carboxylic acid group to the alpha-amino group of N(3)-fumaramoyl-(S)-2,3-diaminopropanoic acid; major species at pH 7.3.


pluronic P-123

A triblock copolymer composed of a central hydrophobic chain of poly(propylene oxide) (70 units) flanked by two hydrophilic chains of poly(ethylene oxide) (20 units each). A polymer with the formula HO[CH2CH2O]2O[CH2CH(CH3)O]70[CH2CH2O]2OH.


triblock copolymer

A polymer composed of three blocks of homopolymers in a linear sequence.


pluronic

A triblock copolymer composed of a central hydrophobic chain of poly(propylene oxide) flanked by two hydrophilic chains of poly(ethylene oxide).


A triblock copolymer composed of a central polybutadiene chain flanked on each side by polystyrene chains.


A linear amino tetrasaccharide consisting of a sequence of beta-D-galactose, N-acetyl-beta-D-glucosamine, beta-D-galactose and N-acetyl-beta-D-glucosamine residues linked (1->4), (1->3) and (1->3).


maltulose

A glycosylfructose consisting of an alpha-D-glucopyranosyl residue joined to beta-D-fructofuranose via a (1->4)-linkage.


name: Vulvar Neoplasm of Skin Appendage Origin

description: A benign or malignant vulvar neoplasm with differentiating characteristics towards sweat or sebaceous glands or hair follicles.  Representative examples include trichoepithelioma, syringoma, and eccrine adenocarcinoma.


Malignant Vulvar Sweat Gland Neoplasm

description: A malignant neoplasm that arises from sweat glands in the vulva. Representative examples include eccrine adenocarcinoma, apocrine adenocarcinoma, and Paget disease.


Vulvar Hidradenoma Papilliferum

description: A benign glandular neoplasm that arises from the vulva. It presents as a mass or cystic lesion in or adjacent to the interlabial sulcus. It is characterized by the presence of complex branching papillae with fibrovascular stalks, lined by uniform columnar epithelial secretory cells and myoepithelial cells.


name: Vulvar Adenocarcinoma of Sweat Gland Origin

description: A rare adenocarcinoma arising from vulvar skin sweat glands.


name: Cirrhosis of the Liver Secondary to Hepatitis C

description: Cirrhosis of the liver that develops as a sequelae of a hepatitis c infection.


A member of the class of triazoles that is 1H-1,2,4-triazole substituted by (1E)-3-amino-2-{4-[(methylsulfonyl)amino]phenyl}-3-oxoprop-1-en-1-yl and 3,5-bis(trifluoromethyl)phenyl groups at positions 1 and 3, respectively. It is an exportin 1 inhibitor.


lactogangliotetraosylceramide

A glycotetraosylceramide Having N-acetyl-beta-D-galactosaminyl-(1->3)-[N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)]-beta-D-glucosyl as the glycotetraosyl component and which is acylated on the amino group by a tetracosanoyl group. A leukaemia-associated antigen with an unusual branching structure.


4alpha-hydroxymethyl steroid

Any steroid which is substituted by a hydroxymethyl group at the 4alpha position.


Any steroid which is substituted by a hydroxymethyl group at position 4.


Any 3beta-hydroxy steroid which is substituted at the 4alpha and 4beta positions by hydroxymethyl and methyl groups, respectively.


4beta-hydroxymethyl steroid

Any steroid which is substituted by a hydroxymethyl group at the 4beta position.


A 4alpha-hydroxymethyl steroid that is 5-alpha-cholest-7-en-3beta-ol in which the alpha-hydrogen at position 4 has been replaced by a hydroxymethyl group.


Any 3beta-hydroxy steroid which is substituted at the 4alpha and 4beta positions by methyl and hydroxymethyl groups, respectively.


A 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid that is 14-demethyllanosterol in which the methyl group at the 4beta position has been oxidised to the corresponding hydroxymethyl group.


(2S,4S)-hypoglycin B

An L-glutamyl amino acid that is (2S,4S)-hypoglycin A in which the amino group has been acylated by the gamma-carboxy group of L-glutamic acid.


(2S,4R)-hypoglycin B

A 5-L-glutamyl amino acid resulting from the formal condensation of the amino group of (2S,4R)-hypoglycin A with the gamma-carboxy group of L-glutamic acid.


pictilisib

A sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring.


dehydrocitreoisocoumarin

A member of the class of isocoumarins that is 1H-isochromen-1-one substituted by a 2,4-dioxopentyl group at position 3 and by hydroxy groups at positions 6 and 8.


An L-alpha-amino acid residue derived from O(3)-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-serine


organorhodium compound

A compound containing at least one carbon-rhodium bond.


rhodium carbene

An organorhodium compound containing a carbon-rhodium double bond.


Stage IIA2 Cervical Cancer FIGO 2018

description: Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement, equal or more than 4 cm in greatest dimension. (FIGO 2018)


(+)-N-methylconiine

A piperidine that is (+)-coniine bering an N-methyl substituent.


PROPAZINE

A  diamino-1,3,5-triazine that is N,N'-di(propan-2-yl)-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.


Any member of the class of 1,3,5-triazines substituted by at least one methoxy group.


acetoguanamine

A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine carrying an additional methyl substituent at position 6.


triflusulfuron

An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens has been replaced by a (2-carboxy-6-methylphenyl)sulfonyl group, while a hydrogen attached to the other nitrogen has been replaced by a 4-(dimethylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl group. An acetolactate synthase inhibitor, it is used (generally as the corresponding methyl ester proherbicide) to control annual and perennial broad-leaved weeds in sugar beet and other crops.


metribuzin-diketo

A member of the class of  1,2,4-triazines that is 1,2,4-triazine-3,5(2H,4H)-dione substituted by an amino group at position 4 and a tert-butyl group at position 6. It is a metabolite of metribuzin.


cyanuric acid

The enol tautomer of isocyanuric acid.


name: 3-[[4,6-bis(4-morpholinyl)-1,3,5-triazin-2-yl]amino]-3-(2-chlorophenyl)propanoic acid ethyl ester


triazine

Any of three isomers generated by replacing three of the carbon atoms of benzene with nitrogen atoms.


naphthyridine

Any one of eight organic heterobicyclic compounds that have a naphthalene skeleton in which two of the carbons are replaced by nitrogens. A 'closed' class.


(R)-secbumeton

The (R)-enantiomer of N-(butan-2-yl)-N'-ethyl-6-methoxy-1,3,5-triazine-2,4-diamine.


DYRENE

A member of the class of triazenes that is dichlorotriazene in which the hydrogen is replaced by an o-chloroanilino group. A fungicide formerly used to control leaf spots and downy mildew, it is no longer approved for use within the European Union.


enasidenib

A 1,3,5-triazine which is substituted by (2-hydroxy-2-methylpropyl)nitrilo, 6-(trifluoromethyl)pyridin-2-yl and [2-(trifluoromethyl)pyridin-4-yl]nitrilo groups at positions 2,4 and 6, respectively. It is an isocitrate dehydrogenase-2 (IDH2) inhibitor which has been approved for the treatment of adults with relapsed or refractory acute myeloid leukaemia (AML).


azaribine

A N-glycosyl-1,2,4-triazine that is 6-azauridine acetylated at positions 2', 3' and 5' on the sugar ring. It is a prodrug for 6-azauridine and is used for treatment of psoriasis.


terbutylazine-desethyl

A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a tert-butyl group at the amino nitrogen and a chloro group at position 6. It is metabolite of the herbicide terbutylazine.


(R)-triaziflam

An N-[1-(3,5-dimethylphenoxy)propan-2-yl]-6-(2-fluoropropan-2-yl)-1,3,5-triazine-2,4-diamine that is the (R)-enantiomer of triaziflam.


deethylatrazine

A chloro-1,3,5-triazine that is  6-chloro-1,3,5-triazine-2,4-diamine in which one of the hydrogens of the amino group is replaced by a propan-2-yl group.


procion red MX-5B

A 2,4-dichloro-1,3,5-triazine with a multi-substituted napthalen-1-ylamino substituent at the 6-position.


An N-(2,6-dimethylindan-1-yl)-6-(1-fluoroethyl)-1,3,5-triazine-2,4-diamine in which the indane moiety has 1R,2S configuration and the fluoroethyl substituent has S configuration. A cellulose biosynthesis inhibitor, it is the minor component of the herbicide indaziflam.


A monoamino-1,3,5-triazine that is 1,3,5-triazin-2-amine substituted by a methoxy group at position 4 and a methyl group at position 6. It is a metabolite of the herbicide thifensulfuron-methyl.


irgarol 1051

A diamino-1,3,5-triazine that is  1,3,5-triazine-2,4-diamine carrying a N-tert-butyl, N'-cyclopropyl and a methylsulfanyl group at position 6.


A tetrazole tautomer where the proton is located on the 2 position.


PROMETRYN

A diamino-1,3,5-triazine that is N,N'-di(propan-2-yl)-1,3,5-triazine-2,4-diamine substituted by a methylsulfanediyl group at position 6.


CINNOLINE

An azaarene that is the 1,2-diaza analogue of naphthalene. The parent of the class of cinnolines.


(S)-triaziflam

An N-[1-(3,5-dimethylphenoxy)propan-2-yl]-6-(2-fluoropropan-2-yl)-1,3,5-triazine-2,4-diamine that is the (S)-enantiomer of triaziflam.


ISOQUINOLINE

An ortho-fused heteroarene that is a benzopyridine in which the N atom not directly attached to the benzene ring.


Compounds based on a triazine skeleton.


A triamino-1,3,5-triazine that is 1,3,5-triazine in which two of the hydrogens have been replaced by morpholin-4-yl groups while the third hydrogen has been replaced by a 2-(difluoromethyl)benzimidazol-1-yl group. It is an inhibitor of phosphatidylinositol 3-kinase.


CYANAZINE

A chloro-1,3,5-triazine that is 2-chloro-1,3,5-triazine substituted by an ethyl amino and a (2-cyanopropan-2-yl)amino group at positions 6 and 4 respectively.


1,3,5-triazinylamino nitrile

Any diamino-1,3,5-triazine in which the amino group is substituted by at least one cyano group.


N-cyclopropylammelide

A dihydroxy-1,3,5-triazine consisting of ammelide bearing an N-cyclohexyl substituent.


A monohydroxy-1,3,5-triazine that is  atrazine in which the chloro group has been replaced by a hydroxy group.


ETHAMETSULFURON METHYL

A methyl ester resulting from the formal condensation of the carboxy group of ethametsulfuron with methanol. A herbicide used for the control of broad-leaved weeds in oil seed rape and fodder rape.


Any compound with a 1,2,4-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 2 and 4 of the core benzene ring structure.


6-AZA-URIDINE MONOPHOSPHATE

A N-glycosyl-1,2,4-triazine that is the 6-aza analogue of uridine 5'-monophosphate.


almitrine

A triamino-1,3,5-triazine compound having allylamino substituents at the 2- and 4-positions and a 4-(bis(p-fluorophenyl)methyl)-1-piperazinyl group at the 6-position.


An N-(2,6-dimethylindan-1-yl)-6-(1-fluoroethyl)-1,3,5-triazine-2,4-diamine in which the indane moiety has 1R,2S configuration and the fluoroethyl substituent has R configuration. A cellulose biosynthesis inhibitor, it is the major active component of the herbicide indaziflam.


PHTHALAZINE

An azaarene that is the 2,3-diaza analogue of naphthalene. The parent of the class of phthalazines.


FAZARABINE

An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-arabinofuranosyl residue via an N-glycosidic linkage. A synthetic analogue of cytosine arabinoside and 5-azacytidine that incorporates structural features of both compounds, it shows good activity against a variety of transplanted tumors.


METRIBUZIN

A member of the class of  1,2,4-triazines that is 1,2,4-triazin-5(4H)-one substituted by an amino group at position 4, tert-butyl group at position 6 and a methylsulfanyl group at position 3.


METSULFURON-METHYL

A N-sulfonylurea in which the sulfonyl group is attached to a 2-(methoxycarbonyl)phenyl group while a (4-methoxy-6-methyl-1,3,5-triazin-2-yl group replaces one of the amino hydrogens of the remaining urea group.


ceftriaxone

A third-generation cephalosporin compound having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups.


A dihydroxy-1,3,5-triazine that is 1,3,5-triazine-2,4-diol substituted by a chloro group at position 6.


(S)-secbumeton

The (S)-enantiomer of N-(butan-2-yl)-N'-ethyl-6-methoxy-1,3,5-triazine-2,4-diamine.


ethametsulfuron

An N-sulfonylurea that is urea in which one of the nitrogens has been substituted by a 4-ethoxy-6-(methylamino)-1,3,5-triazin-2-yl group, while the other has been substituted by a (2-carboxyphenyl)sulfonyl group.


terbumeton

A diamino-1,3,5-triazine that is N-tert-butyl-N'-ethyl-1,3,5-triazine-2,4-diamine substituted by a methoxy group at position 6. It is an agrochemical used as a herbicide.


Any compound with a 1,3,5-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 3 and 5 of the core benzene ring structure.


procion orange MX-2R

A 2,4-dichloro-1,3,5-triazine with a multi-substituted napthalen-2-yldiazenyl substituent at the 6-position.


ATRAZINE

A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.


6-azathymidine 5'-monophosphate

A N-glycosyl-1,2,4-triazine that is the 6-aza analogue of thymidine 5'-monophosphate.


Any member of the class of 1,3,5-triazines that consists of a 1,3,5-triazine skeleton substituted by two amino groups.


A diamino-1,3,5-triazine that is N-(butan-2-yl)-N'-ethyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.


tribenuron

An N-sulfonylurea that is N-(2-carboxybenzenesulfonyl)urea bearing additional methyl and 4-methoxy-6-methyl-1,3,5-triazin-2-yl substituents at position N3. A foliar acting, post-emergence herbicide used to control broad-leaved weeds in cereals, normally used as the methyl variant.


TERBUTRYNE

A methylthio-1,3,5-triazine that is 2-(methylsulfanyl)-1,3,5-triazine substituted by a tert-butylamino and an ethylamino group at positions 2 and 4 respectively.


A 1,2,4-triazine compound having oxo-substituents at the 3- and 5-positions.


A monoamino-1,3,5-triazine that is cytosine in which the aromatic CH at position 5 is replaced by a nitrogen.


TRIBENURON METHYL

The methyl ester of tribenuron.


A member of the class of indanes that is 2,5-dimethylindane in which the hydrogen at position 3 has been replaced by one of the primary amino groups of 6-(1-fluoroethyl)-1,3,5-triazine-2,4-diamine.


metamitron-desamino

A member of the class of 1,2,4-triazines that is  metamitron in which the amino group has been replaced by a hydrogen atom. It is a metabolite of  metamitron.


A nucleobase analogue that is thymine in which the CH group at position 6 is replaced by nitrogen.


SIMETRYN

A diamino-1,3,5-triazine that is N,N'-diethyl-1,3,5-triazine-2,4-diamine substituted by a methylthio group at position 6.


LOGRAN

An N-sulfonylurea that is N-[o-(2-chloroethoxy)phenyl]sulfonylurea in which one of the hydrogens attached to the non-sulfonylated nitrogen has been replaced by a 4-methoxy-6-methyl-1,3,5-triazin-2-yl group. A herbicide used to control broad-leaved weeds in cereals, its use within the EU has been banned after September 2017 on the grounds of potential groundwater contamination and risks to aquatic life.


CHLORSULFURON

An N-sulfonylurea that is N-carbamoyl-2-chlorobenzenesulfonamide in which one of the hydrogens attached to the non-sulfonylated nitrogen has been replaced by a 4-methoxy-6-methyl-1,3,5-triazin-2-yl group. A herbicide used for the control of broadleaf weeds in wheat, barley and oats.


triflusulfuron-methyl

A methyl ester resulting from the formal condensation of the carboxy group of triflusulfuron with methanol. A proherbicide for triflusulfuron.


AMETRYNE

A methylthio-1,3,5-triazine that is 2-(methylsulfanyl)-1,3,5-triazine substituted by an ethylamino and an isopropylamino group at positions 4 and 6 respectively.


name: 5-oxo-3-sulfanylidene-2H-1,2,4-triazine-6-carboxylic acid ethyl ester


PROMETON

A  methoxy-1,3,5-triazine that is 6-methoxy-1,3,5-triazine-2,4-diamine in which the one of the hydrogens of each amino group is substituted by an isopropyl group.


THIFENSULFURON-METHYL

A methyl ester resulting from the formal condensation of the carboxy group of thifensulfuron with methanol. It is used  as a post-emergence herbicide for the control of grass and broad-leaved weeds.


A diamino-1,3,5-triazine that is 1,3,5-triazine substituted by a [1-(3,5-dimethylphenoxy)propan-2-yl]nitrilo group, amino group and 2-fluoropropan-2-yl group at positions 2,4 and 6, respectively.


QUINOLINE

The simplest member of the quinoline class of compounds, comprising a benzene ring ortho fused to C-2 and C-3 of a pyridine ring.


A diamino-1,3,5-triazine that is N-(propan-2-yl)-1,3,5-triazine-2,4-diamine substituted by a hydroxy group at position 2. It is a metabolite of the herbicide atrazine.


An organosulfonic acid comprising stilbene having 4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino groups at the 4 and 4'-positions and sulfo groups at the 2- and 2'-positions.


(R)-sebuthylazine

The (R)-enantiomer of N-(butan-2-yl)-6-chloro-N'-ethyl-1,3,5-triazine-2,4-diamine.


simeton

A methoxy-1,3,5-triazine that is  6-methoxy-1,3,5-triazine-2,4-diamine in which one of the hydrogens of each amino group has been replaced by an ethyl group.


iofensulfuron

An N-sulfonylurea that is N-carbamoyl-2-iodobenzenesulfonamide bearing a 4-methoxy-6-methyl-1,3,5-triazin-2-yl substituent at position N3.


SIMAZINE

A diamino-1,3,5-triazine that is N,N'-diethyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.


melamine

A trimer of cyanamide, with a 1,3,5-triazine skeleton.


PYMETROZINE

A member of the class of 1,2,4-triazines that is 4,5-dihydro-1,2,4-triazin-3(2H)-one substituted by a methyl group at position 6 and a (pyridin-3-ylmethylidene)amino group at position 4.


cyanuric chloride

A chloro-1,3,5-triazine in which the triazine ring is substituted on each carbon by chlorine. Its main use is in the preparation of the triazine-class pesticides.


tetrazole

An  azaarene that is a five-membered ring composed of 4 nitrogen and 1 carbon atom.


A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a methylsulfanyl group at position 6 and a tert-buty group at the amino nitrogen atom.


cycloguanil

A triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil.


A diamino-1,3,5-triazine that is 1,3,5-triazin-2-ol substituted by a tert-butylamino group at position 4 and an ethylamino group at position 6. It is a metabolite of the herbicide terbutylazine,


secbumeton

A racemate composed of equimolar amounts of (R)- and (S)-secbumeton. It is an agrochemical used as a herbicide.


A diamino-1,3,5-triazine that is N,N'-diethyl-1,3,5-triazine-2,4-diamine substituted by a hydroxy group at position 2. It is a metabolite of the herbicide simazine.


METAMITRON

A member of the class of 1,2,4-triazines that is 1,2,4-triazin-5(4H)-one substituted by an amino group at position 4, a methyl group at position 3 and a phenyl group at position 6.


hydralazine

The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.


QUINAZOLINE

A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.


Terbuthylazine

A diamino-1,3,5-triazine that is N-tert-butyl-N'-methyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.


A N-glycosyl-1,2,4-triazine that is the 6-aza analogue of thymidine.


A diamino-1,3,5-triazine that is 1,3,5-triazin-2-ol substituted by an amino group at position 4 and a tert-butylamino group at position 6. It is metabolite of the herbicide terbutylazine.


tritosulfuron

A sulfonamide  that is benzenesulfonamide substituted by a trifluoromethyl group at position 2 and a [4-methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-yl]carbamoyl group at the nitrogen atom.


(S)-sebuthylazine

The (S)-enantiomer of N-(butan-2-yl)-6-chloro-N'-ethyl-1,3,5-triazine-2,4-diamine.


azacitidine

An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.


name: 4-morpholinecarbodithioic acid [4-amino-6-(4-methylanilino)-1,3,5-triazin-2-yl]methyl ester


A member of the class of 1,2,4-triazines in which the triazine ring is substituted at positions 3, 5, and 6 by pyridin-2-yl, ([biphenyl]-4-ylmethyl)amin, and methyl groups, respectively. It is an activator of the hypoxia inducible factor (HIF) pathway.


thifensulfuron

An N-sulfonylurea in which the sulfur atom is attached to a 2-carboxythiophen-3-yl group and in which the non-sulfonated nitrogen is substituted by a 4-methoxy-6-methyl-1,3,5-triazin-2-yl group. The corresponding methyl ester, known as thifensulfuron-methyl, is used as a post-emergence herbicide for the control of grass and broad-leaved weeds.


N-isopropylammelide

A dihydroxy-1,3,5-triazine consisting of ammelide bearing an N-isopropyl substituent.


A member of the class of 1,3,5-triazines that is 1,3,5-triazine substituted by at least one chloro group at unspecified position.


triafamone

A methoxy-1,3,5-triazine that is 1,3,5-triazine substituted by 2-{[(difluoromethyl)sulfonyl](methyl)amino}-3-fluorobenzoyl, methoxy and methoxy groups at positions 2, 4, and 6, respectively. It is a herbicide developed by Bayer CropScience AG for weed control in rice and its mode of action is inhibition of the enzyme acetolactate synthase.


atraton

A diamino-1,3,5-triazine that is N-ethyl-N'-(propan-2-yl)-1,3,5-triazine-2,4-diamine substituted by a methoxy group at position 6. It is an agrochemical used as a herbicide.


A tetrazole tautomer where the proton is located on the 1st position.


name: N,N-dimethylcarbamothioic acid O-[4-[2-[(4-chlorophenyl)thio]-1-oxoethyl]-2,6-dimethylphenyl] ester


Anaplastic Hemispheric Astrocytoma

description: An anaplastic astrocytoma that arises from the cerebral hemispheres.


name: Recurrent Diffuse Hemispheric Glioma, H3 G34-Mutant

description: The reemergence of diffuse hemispheric glioma, H3 G34-mutant after a period of remission.


Frontal Lobe Anaplastic Astrocytoma

description: An anaplastic astrocytoma occurring in the frontal lobe.


Cerebral Hodgkin Lymphoma

description: A Hodgkin lymphoma that arises from the cerebral hemispheres as a primary lesion.


name: Infant-Type Hemispheric Glioma, MET-Altered

description: A high-grade cellular astrocytoma that arises in the cerebral hemisphere and occurs in early childhood. It is characterized by receptor tyrosine kinase fusions in the MET gene.


Parietal Lobe Anaplastic Astrocytoma

description: An anaplastic astrocytoma occurring in the parietal lobe.


name: Infant-Type Hemispheric Glioma, ALK-Altered

description: A high-grade cellular astrocytoma that arises in the cerebral hemisphere and occurs in early childhood. It is characterized by receptor tyrosine kinase fusions in the ALK gene.


Temporal Lobe Anaplastic Astrocytoma

description: An anaplastic astrocytoma occurring in the temporal lobe.


name: Unresectable Diffuse Hemispheric Glioma, H3 G34-Mutant

description: Diffuse hemispheric glioma, H3 G34-mutant that is not amenable to surgical resection.


name: Adult Diffuse Hemispheric Glioma, H3 G34-Mutant

description: A diffuse hemispheric glioma, H3 G34-mutant that occurs in young adults.


name: Childhood Cerebral Anaplastic Astrocytoma

description: A cerebral anaplastic astrocytoma that occurs during childhood.


name: Childhood Diffuse Hemispheric Glioma, H3 G34-Mutant

description: A diffuse hemispheric glioma, H3 G34-mutant that occurs during childhood.


name: Infant-Type Hemispheric Glioma, NTRK-Altered

description: A high-grade cellular astrocytoma that arises in the cerebral hemisphere and occurs in early childhood. It is characterized by receptor tyrosine kinase fusions in the NTRK family.


lead chromate

A chromium coordination entity comprising chromate and lead(2+) ions in a 1:1 ratio


A hydroxypyridine that is pyridine substituted by hydroxy groups at positions 2,3 and 5 and a chloro group at position 6. It is a metabolite of the agrochemical chlorpyrifos.


A terminal acetylenic compound that is butane carrying a triple bond at position 1.


A zwitterionic group obtained by transfer of a proton from the phosphate to the amino group of any 3'-(D-alpha-aminoacyl)adenylyl group. Major microspecies at pH 7.3 (according to Marvin v. 6.2.0).


cobimetinib

A member of the class of N-acylazetidines obtained by selective formal condensation of the carboxy group of 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid with the secondary amino group from the azetidine ring of 3-[(2S)-piperidin-2-yl]azetidin-3-ol. An inhibitor of mitogen-activated protein kinase that is used (as its fumarate salt) in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma.


name: Epithelioid Hemangioendothelioma with WWTR1-CAMTA1 Gene Fusion

description: Epithelioid hemangioendothelioma characterized by a t(1;3)(p36;q23-q25) translocation, resulting in a WWTR1-CAMTA1 gene fusion. This translocation and associated gene fusion occur in more than 90% of epithelioid hemangioendotheliomas.


An organic heterooctacyclic compound that is 1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of 3-amino-N,2-dimethyloxolane-3-carboxamide (the 2R,3R,5S product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling to positions 3 and 4 of 1,5-dihydro-2H-pyrrol-2-one.


A para-terphenyl that is the 6'-O-desmethyl deriavtive of  terphenyllin. Isolated from Penicillium chermesinum, it exhibits inhibitory activity against alpha-glucosidase.


name: Laryngeal Inflammatory Myofibroblastic Tumor

description: An inflammatory myofibroblastic tumor that arises from the larynx.


KADSURENIN L

A neolignan with formula C23H28O6, originally isolated from Piper kadsura.


D-fuculose

A fuculose with D-configuration.


A trisaccharide that is beta-D-galactopyranose in which the hydroxy groups at positions 2 and 3 have each been converted into the corresponding beta-D-glucopyranoside.


CYCLOMORUSIN

An extended flavonoid that is cyclomulberrin in which the hydroxy group at position 10 has undergone oxidative cyclisation to position 3 of the 3-methylbut-2-en-1-yl substituent, with migration of the double bond into conjugation with the aromatic ring. It is a moderate inhibitor of acetylcholinesterase (IC50 = 16.2 - 36.6 muM), and a  strong inhibitor of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) induced platelet aggregation.


A beta-D-galactoside that is the 4-methoxyphenyl glycoside of a disaccharide consisting of a 3-O-sulfo-beta-D-glucuronic acid residue linked (1->3) to beta-D-galactose.


Any anthocyanidin glucoside in which a 6-O-(4-hydroxycinnamoyl)-beta-D-glucosyl residue is attached at position 3 (R groups may be H).


A dihydroxyflavanone having the two hydroxy groups located at the C-4' and -7 positions and two additional methoxy substituent at the C-3' and 8-positions.


dimethoxyflavanone

A methoxyflavanone that is flavanone with two methoxy substituents.


A dimethoxyflavanone that is naringenin in which the hydroxy groups at positions 4' and 7 are replaced by methoxy groups.


pisonivanol

A dihydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 3 and 7 and methoxy groups at positions 5 and 6. It has been isolated from Pisonia aculeata.


A dimethoxyflavanone that is (2S)-(-)-kurarinone in which the hydroxy group at position 2' is replaced by a methoxy group. Isolated from the roots of Sophora flavescens, it exhibits cytotoxicity against human myeloid leukemia HL-60 cells.


methyl hesperidin

A flavanone glycoside that is hesperidin in which the hydroxy group at position 3' has been replaced by a methoxy group.


A dimethoxyflavanone that is flavanone substituted by methoxy groups at positions 5 and 7 and hydroxy groups at positions 6 and 4'.


An extended flavonoid that is 3',4'-methylenedioxyflavanone substituted by methoxy groups at positions 5 and 7 and a 2-hydroxy-3-methyl-3-butenyl moiety at position 8 (the 2S stereoisomer). Isolated from the stem barks of Pongamia pinnata, it acts as a an inducer of quinone reductase, a phase II enzyme that protects cells against reactive, toxic and potentially carcinogenic species.


homoferreirin

A dihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5 and 7 and methoxy groups at positions 2' and 4' respectively.


A dimethoxyflavanone that is 5,7-dimethoxyflavanone substituted by a formyl group at position 8. Isolated from the stem bark of Pongamia pinnata, it acts as a an inducer of quinone reductase, a phase II enzyme that protects cells against reactive, toxic and potentially carcinogenic species.


The organoarsonic acid anion formed by loss of a single proton from the arsonic acid grouping in phenylarsonic acid.


2-amino-2-deoxy-D-mannonic acid

A mannonic acid derivative in which the hydroxy group at position 2 has been replaced by an amino group.


mannonic acid derivative

A hexonic acid derivative that is formally obtained from a mannonic acid.


9-ribosyl-trans-zeatin 5'-diphosphate

A purine ribonucleoside 5'-diphosphate that is ADP substituted at position N-6 by a (2E)-4-hydroxy-3-methylbut-2-en-1-yl group.


Major species at pH 7.3.


TuMP

A ribonucleoside monophosphate that is tubercidin with a phosphate group replacing the hydrogen on the 5'-hydroxy group.


A (2'->5')-dinucleotide made up from guanosine-5'-triphosphate and adenosine-5'-monophosphate residues


An L-lysyl ester obtained by formal condensation of the carboxy group of L-lysine with the 3'-hydroxy group of AMP.


A ribonucleoside 5'-monophosphate having (2S)-2-amino-4-(6-methyl-9-oxo-4,9-dihydro-3H-imidazo[1,2-a]purin-7-yl)butanoic acid as the nucleobase.


A nucleoside 3',5'-cyclic phosphate that is cAMP in which the nitrogen atom at position 7 on the purine fragment is replaced by a methine (C-H) group.


A purine ribonucleoside 5'-tetraphosphate compound having 5'-xanthosyl residues at the P(1)- and P(4)-positions.


A 2',3'-cyclic purine nucleotide that is GMP in which the hydroxy groups at the 2' and 3' positions have been converted into the corresponding cyclic phosphate.


guanyl ribonucleotide

A purine ribonucleotide where the purine is guanine.


lipoyl-AMP

A purine ribonucleoside 5'-monophosphate having adenine as the nucleobase and a lipoyl group attached to one of the phosphate OH groups.


A pyrimidine ribonucleoside 5'-monophosphate having 5-aminomethyl-2-thiouracil as the nucleobase.


6-deoxyinosine 5'-phosphate

The 5'-monophosphate of 6-deoxyinosine.


A 2',3'-cyclic purine nucleotide that is AMP in which the hydroxy groups at the 2' and 3' positions have been converted into the corresponding cyclic phosphate.


A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP in which the hydrogen at position 2 on the purine fragment is replaced by a 6-aminohexylthio group.


N(4)-acetylcytidine 5'-monophosphate

A pyrimidine ribonucleoside 5'-monophosphate having N(4)-acetylcytosine as the nucleobase.


purine ribonucleotide

Any ribonucleotide that has a purine nucleobase.


A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP in which the hydrogen at position 2 on the purine fragment is replaced by a 4-chlorophenylthio group.


adenosine 5'-hexadecylphosphate

An adenosine 5'-phosphate that is the monohexadecyl ester of AMP.


A cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 2',5'-linkages.


A cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'- and 2',5'-linkages respectively.


A purine ribonucleoside 5'-diphosphate that is ADP substituted at position 3' by an N-methylanthraniloyl group.


An L-cysteinyl ester obtained by formal condensation of the carboxy group of L-cysteine with the 3'-hydroxy group of AMP.


A purine ribonucleoside 5'-monophosphate that is AMP substituted at C-2 by a methylthio group and at N-6 by a dimethylallyl group.


A ribonucleotide that is the 3'-dehydro derivative of adenosine 5'-triphosphate.


dodecanoyl-AMP

A fatty acyl-AMP that results from the formal condensation of the phosphoryl group of AMP with the carboxyl group of dodecanoic (lauric) acid.


A purine ribonucleoside 5'-monophosphate compound having 6-aminopurine as the nucleobase.


A (3'->5')-dinucleotide composed from guanosine and cytidine units.


A purine ribonucleoside 5'-monophosphate that is AMP substituted at C-2 by a thio group and at N-6 by a dimethylallyl group.


An L-tryptophan derivative that is the ester obtained by formal condensation of the carboxy group of L-tryptophan with the 3'-hydroxy group of AMP.


NMNH

A nicotinamide mononucleotide that is obtained by addition of hydride to position 4 on the pyridine ring of NMN(+).


benzoyl-AMP

A purine ribonucleoside 5'-monophosphate that is adenosine 5'-monophosphate in which one of the hydroxy groups of the phosphate has been condensed with the carboxylic acid group of benzoic acid.


N(4)-methylcytidine 5'-monophosphate

A pyrimidine ribonucleoside 5'-monophosphate having N(4)-methylcytosine as the nucleobase.


A uridine 5'-phosphate that is UMP in which the hydroxy hydrogen at position 3 has been replaced by an enolpyruvyl group.


The N(6)-dimethylallyl derivative of adenosine 5'-monophosphate.


A purine ribonucleoside 5'-diphosphate that is GDP substituted at position 2' by an N-methylanthraniloyl group.


guanosine 3'-monophosphate

A guanosine 3'-phosphate compound with a monophosphate group at the 3'-position.


An L-glutamyl ester obtained by formal condensation of the alpha-carboxy group of L-glutamic acid with the 3'-hydroxy group of AMP.


A purine ribonucleoside 5'-monophosphate that is the 8-oxo form of GMP.


A pyrimidine ribonucleoside 5'-monophosphate having 5-methylaminomethyl-2-thiouracil as the nucleobase.


A nucleoside 3',5'-cyclic phosphate that is 7-deaza-cAMP substituted at position 8 by a chloro group.


A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP in which the hydrogen at position 2 on the purine fragment is replaced by a 6-aminohexylthio group.


carbamoyl adenylate

A purine ribonucleoside 5'-monophosphate that is AMP in which one of the phosphate OH groups substituted by a carbamoyl group


cangrelor

A nucleoside triphosphate analogue that is 5'-O-[({[dichloro(phosphono)methyl](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]adenosine carrying additional 2-(methylsulfanyl)ethyl and (3,3,3-trifluoropropyl)sulfanyl substituents at positions N6 and C2 respectively. Used (in the form of its tetrasodium salt) as an intravenous antiplatelet drug that prevents formation of harmful blood clots in the coronary arteries.


(R)-lipoyl-GMP

An acyclic mixed acid anhydride that results from the formal condensation of the phosphoryl group of GMP with the carboxyl group of lipoic acid.


The N(6)-(1,2-dicarboxyethyl) derivative of adenosine 5'-monophosphate.


adenyl ribonucleotide

A purine riboncleotide where adenine is the purine.


A pyrimidine ribonucleoside 5'-monophosphate having 5-carboxymethylaminouracil as the nucleobase.


An L-isoleucine derivative that is the ester obtained by formal condensation of the carboxy group of L-isoleucine with the 3'-hydroxy group of AMP.


The purine ribonucleoside 5'-monophosphate that is AMP monomethylated on N(6).


A cyclic adenyl ribonucleotide that is cAMP (cyclic adenosine 3',5'-phosphate) in which the hydrogen at position 8 has been replaced by a piperidin-1-yl group. A selective cAMP-dependent protein kinase A (PKA) activator and cAMP analogue with high selectivity for site A of PKA type I and for site B of PKA type II.


An L-leucine derivative that is the ester obtained by formal condensation of the carboxy group of L-leucine with the 3'-hydroxy group of AMP.


A purine ribonucleoside 5'-diphosphate that is the 8-oxo derivative of GDP.


An L-proline derivative that is the ester obtained by formal condensation of the carboxy group of L-proline with the 3'-hydroxy group of AMP.


A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP in which the hydrogen at position 2 on the purine fragment is replaced by a 6-aminohexylamino group


An adenosine 5'-phosphate derivative that has the structure of acetyl-coenzyme A dephosphorylated at C-3' and with a 5''-phospho-D-ribosyl substituent at C-2'.


A purine ribonucleoside 5'-tetraphosphate compound having a 5'-adenosyl residue at the P(1)-position and a 5'-guanosyl residue at the P(4)-position.


formycin 3',5'-cyclic phosphate

A nucleoside 3',5'-cyclic phosphate derived from formycin A.


An acyclic mixed acid anhydride that results from the formal condensation of the phosphoryl group of AMP with the carboxyl group of 4-hydroxybenzoic acid.


5'-adenylyl sulfate

An adenosine 5'-phosphate having a sulfo group attached to one the phosphate OH groups.


2-methyladenosine 5'-monophosphate

A purine ribonucleoside 5'-monophosphate having 2-methyladenine as the nucleobase.


A purine ribonucleoside 5'-monophosphate having N,N-dimethylguanine as the nucleobase.


Major species at pH 7.3.


N(2)-methylguanosine 5'-monophosphate

A purine ribonucleoside 5'-monophosphate that is GMP bearing an N(2)-methyl substituent.


An L-asparaginyl derivative that is the ester obtained by formal condensation of the carboxy group of L-asparagine with the 3'-hydroxy group of AMP.


ribonucleoside 3'-monophosphate

A ribonucleoside monophosphate in which the phosphate group is at the ribosyl 3-position.


6-oxouridine 5'-phosphate

A pyrimidine ribonucleoside 5'-monophosphate that is the 6-oxo derivative of UMP.


A secondary alpha-hydroxy ketone that is adenosine 5'-monophosphate in which the hydroxy group at position 3' is replaced by an oxo group.


A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP in which the hydrogen at position 2 on the purine fragment is replaced by a 4-chlorophenylthio group.


diquafosol

A pyrimidine ribonucleoside 5'-tetraphosphate compound having 5'-uridinyl residues at the P(1)- and P(4)-positions.


A ribonucleoside 5'-monophosphate that is wyosine 5'-monophosphate substituted at position 7 by a 3-amino-3-carboxypropyl group.


An L-serine derivative that is the ester obtained by formal condensation of the carboxy group of L-serine with the 3'-hydroxy group of AMP.


(R)-lipoyl-AMP

A lipoyl-AMP in which the lipoyl moiety has (R)-configuration.


A nucleoside pentaphosphate that is adenosine in which a hexahydrogen pentaphosphate is attached at the 5' position.


A purine ribonucleoside 5'-diphosphate having 7-methyl-7,8-dihydroguanine as the nucleobase.


A  (2'->5')-dinucleotide comprising guanosine and adenosine connected by a 2'->5' linkage and with a phosphate group at the 3'-terminus.


A purine ribonucleoside 5'-diphosphate that is GDP substituted at the 3' position by an N-methylanthraniloyl group.


An L-methionine derivative that is the ester obtained by formal condensation of the carboxy group of L-methionine with the 3'-hydroxy group of AMP.


An adenosine and a guanosine connected by a 3'->5 phosphate linkage; major species at pH 7.3.; major species at pH 7.3.


A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP in which the exocyclic amino group on the purine fragment is carrying a 6-aminohexyl substituent.


beta-hydroxywybutosine 5'-monophosphate

A ribonucleotide that is the 5'-monophosphate derivative of  beta-hydroxywybutosine.


An acyclic mixed acid anhydride that results from the formal condensation of the phosphoryl group of AMP with the carboxy group of 19-(4-hydroxyphenyl)nonadecanoic acid.


7-methylguanosine 5'-diphosphate(1+)

A guanosine 5'-phosphate that consists of guanosine 5'-diphosphate bearing a 7-methyl substituent.


An acyclic mixed acid anhydride that results from the formal condensation of the phosphoryl group of AMP with the carboxyl group of 2-hydroxybenzoic acid.


5-bromouridine 5'-monophosphate

A pyrimidine ribonucleoside 5'-monophosphate having 5-bromouracil as the pyrimidine component.


XDP

A purine ribonucleoside 5'-diphosphate having xanthosine as the nucleobase.


7-methylguanosine 5'-diphosphate

A guanosine 5'-phosphate that consists of guanosine 5'-diphosphate bearing a 7-methyl substituent and having a negatively charged diphosphate group.


2'-O-methylguanosine 5'-monophosphate

A guanosine 5'-phosphate that is the 2'-O-methyl derivative of guanosine 5'-monophosphate.


L-seryl-AMP

A purine ribonucleoside 5'-monophosphate that is adenosine 5'-monophosphate in which one of the hydroxy groups of the phosphate has been condensed with the carboxylic acid group of L-serine.


A  purine ribonucleoside 5'-monophosphate that is adenosine 5'-monophosphate substituted on N-6 by geminal methyl groups.


2'-O-methylcytidine 5'-monophosphate

A pyrimidine ribonucleoside 5'-monophosphate that is CMP monomethylated at position O-2'


A guanosine 5'-phosphate that is the N(2),N(2),N(7)-trimethyl derivative of guanosine 5'-monophosphate.


A glycinyl ester obtained by formal condensation of the carboxy group of glycinne with the 3'-hydroxy group of AMP.


L-threonyl-AMP

A purine ribonucleoside 5'-monophosphate that is adenosine 5'-monophosphate in which one of the hydroxy groups of the phosphate has been condensed with the carboxylic acid group of L-threonine.


A 3',5'-cyclic purine nucleotide obtained by oxygenation of the nitrogen at position 1 on the purine fragment of 3',5'-cyclic AMP.


propanoyl-AMP

A purine ribonucleoside 5'-monophosphate consisting of adenosine 5'-monophosphate where one of the hydroxy groups of the phosphate has been condensed with propionic acid.


A pyrimidine ribonucleoside 5'-monophosphate having 5-carboxymethylamino-2-thiouracil as the nucleobase.


2'-O-methyladenosine 5'-monophosphate

A adenosine 5'-phosphate that is the 2'-O-methyl derivative of adenosine 5'-monophosphate.


9-ribosyl-trans-zeatin 5'-monophosphate

A purine ribonucleoside 5'-monophosphate that is AMP substituted at position N-6 by a (2E)-4-hydroxy-3-methylbut-2-en-1-yl group.


A purine ribonucleoside 5'-tetraphosphate having adenine as the nucleobase.


D-alanyl-AMP

A purine ribonucleoside 5'-monophosphate that is adenosine 5'-monophosphate in which one of the hydroxy groups of the phosphate has been condensed with the carboxylic acid group of D-alanine.


A nucleoside 3',5'-cyclic phosphate that is cGMP in which the nitrogen atom at position 7 on the purine fragment is replaced by a methine (C-H) group


Major species at pH 7.3.


glycyl-AMP

A purine ribonucleoside 5'-monophosphate that is adenosine 5'-monophosphate in which one of the hydroxy groups of the phosphate has been condensed with the carboxylic acid group of glycine.


N(3)-methyluridine 5'-monophosphate

A pyrimidine ribonucleoside 5'-monophosphate having 3-methyluracil as the nucleobase.


An L-glutaminyl derivative that is the ester obtained by formal condensation of the carboxy group of L-glutamine with the 3'-hydroxy group of AMP.


A guanosine bisphosphate having a diphosphate at the 3'-position and a triphosphate at the 5'-position.


adenosylcobinamide guanosyl diphosphate

A cobalt corrinoid consisting of cobinamide guanosyl diphosphate having a 5'-adenosyl group attached to the central cobalt atom.


A purine ribonucleoside 5'-diphosphate that is ADP substituted at position N-6 by a dimethylallyl (isopentenyl) group.


An L-phenylalanine derivative that is the ester obtained by formal condensation of the carboxy group of L-phenylalanine with the 3'-hydroxy group of AMP.


A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP in which the exocyclic amino group on the purine fragment is carrying a butyryl substituent.


A pyrimidine ribonucleoside 5'-monophosphate that is the  5-carboxymethylaminomethyl-2'-O-methyl derivative of uridine 5'-monophosphate.


4-demethylwyosine 5'-monophosphate

A ribonucleotide that is the 5'-monophosphate derivative of 4-demethylwyosine.


An adenosine 5'-monophosphate having a salicyl group at the 3'-position; intermediate in mycobactin biosynthesis.


A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP in which the hydrogen at position 2 on the purine fragment is replaced by a dimethylamino group.


A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP bearing an additional bromo substituent at position 8 on the adenine ring. An activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.


An acyclic mixed acid anhydride obtained by condensation of one of the carboxy group of pyridinium-3,5-biscarboxylic acid mononucleotide with the phosphste group of AMP.


An L-alanyl ester obtained by formal condensation of the carboxy group of L-alanine with the 3'-hydroxy group of AMP.


An acyclic mixed acid anhydride obtained by condensation of one of the carboxy group of pyridinium-3-sulfanylcarbonyl-5-carboxylic acid mononucleotide with the phosphste group of AMP.


An adenosine 5'-phosphate derivative that has the structure of coenzyme A dephosphorylated at C-3' and with a 5''-phospho-D-ribosyl substituent at C-2'.


An acyclic mixed acid anhydride that results from the formal condensation of the phosphoryl group of AMP with the carboxyl group of 2-amino-3-hydroxy-4-methylbenzoic acid.


N(3)-methylcytidine 5'-monophosphate

A pyrimidine ribonucleoside 5'-monophosphate having N(3)-methylcytosine as the nucleobase.


An L-valyl ester obtained by formal condensation of the carboxy group of L-valine with the 3'-hydroxy group of AMP.


adenosine thiamine triphosphate

An adenosine 5'-phosphate obtained by formal condensation of the hydroxy group of thiamine with the triphosphate group of ATP.


An adenosine 5'-phosphate derivative that has the structure of coenzyme A dephosphorylated at C-3' and with a 5-triphospho-alpha-D-ribosyl substituent at C-2'.


TDP

A pyrimidine ribonucleoside 5'-diphosphate in which the pyrimidine element is 5-methyluracil.


N(7)-methylguanosine 5'-phosphate

A guanosine 5'-phosphate that is the N(7)-methyl derivative of guanosine 5'-monophosphate.


c-GMP-AMP

A cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'-linkages.


cyclic di-AMP

A cyclic purine dinucleotide that is the 3',5'-cyclic dimer of AMP.


hexadecanoyl-AMP

A fatty acyl-AMP that results from the formal condensation of the phosphoryl group of AMP with the carboxyl group of hexadecanoic (palmitic) acid.


A purine ribonucleoside 5'-monophosphate that is the 2-oxo derivative of AMP.


A ribonucleoside 5'-monophosphate that is wyosine 5'-monophosphate substituted at position 7 by a 2-hydroxy-3-amino-3-carboxypropyl group.


name: Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester


An L-tyrosyl ester obtained by formal condensation of the carboxy group of L-tyrosine with the 3'-hydroxy group of AMP.


IDP

A purine ribonucleoside 5'-diphosphate having inosine as the nucleobase.


A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP in which the hydrogen at position 2 on the purine fragment is replaced by a 6-aminohexylamino group.


N(1)-methylguanosine 5'-monophosphate

A purine ribonucleoside 5'-monophosphate that is GMP bearing a methyl substituent at position 1.


A cytidine 3'-phosphate compound with a monophosphate group at the 3'-position.


fatty acyl-AMP

An acyl-AMP that results from the formal condensation of the phosphoryl group of AMP with the carboxyl group of any fatty acid.


urate D-ribonucleotide

A purine ribonucleoside 5'-monophosphate consisting of 5'-xanthylic acid having an oxo group at the 8-position.


inosine 3'-monophosphate

An inosine phosphate having a monophosphate group located at the 3'-position.


A guanosine 5'-phosphate that is the N(2),N(2),N(7)-trimethyl derivative of guanosine 5'-triphosphate.


A purine ribonucleoside 5'-monophosphate that is the 2-hydroxylated form of AMP.


An L-aspartic acid derivative that is the ester obtained by formal condensation of the alpha-carboxy group of L-aspartic acid with the 3'-hydroxy group of AMP.


An L-threonine derivative that is the ester obtained by formal condensation of the carboxy group of L-threonine with the 3'-hydroxy group of AMP.


octanediol

A glycol in which the two hydroxy groups are on different carbon atoms of an unbranched saturated chain of eight carbon atoms.


A pyranone that is 4-hydroxy-3-methyl-2H-pyran-2-one in which two of the hydrogens of the methyl group are replaced by a cycloprop-2-en-1-yl group and a 3-{[N-(tert-butoxycarbonyl)-beta-alanyl]amino}phenyl group (S-configuration) and in which the hydrogen at position 6 is replaced by a 1-phenylbutan-2-yl group (R-configuration).


Recurrent Sarcoma of the Extremity

description: A sarcoma of the soft tissues or bones of the upper or lower extremity that has recurred after a period of remission.


name: Stage II Small Intestinal Gastrointestinal Stromal Tumor

description: Stage II includes: T3, N0, M0, Mitotic rate: Low.  T3: Tumor more than 5 cm, but not more than 10 cm, in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Stage III Rectal Cancer AJCC v7

description: Stage III includes: IIIA (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  N1: Metastasis in 1-3 regional lymph nodes.  N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2: Metastasis in four or more regional lymph nodes.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Cecum Neuroendocrine Tumor

description: A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the cecum.


Advanced Colorectal Carcinoma

description: Colorectal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Hereditary Colon Carcinoma

description: Colon carcinoma that has developed in relatives of patients with a history of colon carcinoma.


Colorectal Neuroendocrine Tumor

description: A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the colon or rectum.


name: Stage IIB Small Intestinal Cancer AJCC v7

description: Stage IIB includes: T4, N0, M0. T4: Tumor perforates the visceral peritoneum or directly invades other organs or structures (including other loops of small intestine, mesentery, or retroperitoneum more than 2 cm, and abdominal wall by way of serosa; for duodenum only, invasion of pancreas or bile duct). N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Intestinal Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the small or large intestine. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Intestinal Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the small or large intestine. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Non-Neoplastic Intestinal Disorder

description: A disorder that affects the small or large intestine and is non-neoplastic in nature. Representative examples include acute appendicitis, colitis, and inflammatory bowel disease.


Colorectal Conventional Adenoma

description: A benign, premalignant colorectal neoplasm composed of dysplastic epithelium. The descriptor "conventional" distinguishes this from lesions in the serrated pathway. (WHO 2019)


Stage II Colorectal Cancer AJCC v8

description: Stage II includes: IIA: T3, N0, M0; IIB: T4a, N0, M0; IIC: T4b, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Colon Serrated Adenocarcinoma

description: A rare, invasive colon adenocarcinoma characterized by the presence of a malignant infiltrate with serrated glandular architecture.


Jejunal web

description: The formation of tissue in the lumen of the jejunum that results in partial obstruction.


name: Adenoma of the Colon with Intramucosal Adenocarcinoma

description: An intramucosal malignant glandular epithelial infiltrate in a colonic adenoma.  There is no evidence of submucosal invasion.


Rectal Conventional Adenoma

description: A benign, premalignant rectal neoplasm composed of dysplastic epithelium. The descriptor "conventional" distinguishes this from lesions in the serrated pathway. (WHO 2019)


name: Small Intestinal Undifferentiated Carcinoma

description: A carcinoma that arises from the small intestine.  It is composed of malignant epithelial cells which do not display evidence of glandular, squamous, or transitional cell differentiation.