para-coumaric acid

The trans-isomer of 4-coumaric acid.


FBLN1_HUMAN Fibulin-1 (sprot)

A fibulin-1 that is encoded in the genome of human.


name: NCTR3_HUMAN Natural cytotoxicity triggering receptor 3 (sprot)

description: A natural cytotoxicity triggering receptor 3 that is encoded in the genome of human.


name: VASP_HUMAN Vasodilator-stimulated phosphoprotein (sprot)

description: A vasodilator-stimulated phosphoprotein that is encoded in the genome of human.


name: IL12A_HUMAN Interleukin-12 subunit alpha (sprot)

description: An interleukin-12 subunit alpha that is encoded in the genome of human.


Subdural hemorrhage

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Hemorrhage occurring between the dura mater and the arachnoid mater.


name: PP4C_HUMAN Serine/threonine-protein phosphatase 4 catalytic subunit (sprot)

description: A serine/threonine-protein phosphatase 4 catalytic subunit that is encoded in the genome of human.


ACETONE

A methyl ketone that consists of propane bearing an oxo group at C2.


name: PLAT4_HUMAN Phospholipase A and acyltransferase 4 (sprot)

description: A phospholipase A and acyltransferase 4 that is encoded in the genome of human.


name: KDM2A_HUMAN Lysine-specific demethylase 2A (sprot)

description: A lysine-specific demethylase 2A that is encoded in the genome of human.


pemoline

A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.


delusional disorder

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A disorder characterized by the presence of one or more nonbizarre delusions that persist for at least 1 month; the delusion(s) are not due to schizophrenia or a mood disorder, and do not impair psychosocial functioning apart from the ramifications of the delusion(s).


name: KKCC2_HUMAN Calcium/calmodulin-dependent protein kinase kinase 2 (sprot)

description: A calcium/calmodulin-dependent protein kinase kinase 2 that is encoded in the genome of human.


name: OLR1_HUMAN Oxidized low-density lipoprotein receptor 1 (sprot)

description: An oxidized low-density lipoprotein receptor 1 that is encoded in the genome of human.


name: MSX2_HUMAN Homeobox protein MSX-2 (sprot)

description: A homeobox protein MSX-2 that is encoded in the genome of human.


name: NTCP2_HUMAN Ileal sodium/bile acid cotransporter (sprot)

description: An ileal sodium/bile acid cotransporter that is encoded in the genome of human.


name: isolated growth hormone deficiency type IA

description: An isolated growth hormone deficiency characterized by autosomal recessive inheritance of severe dwarfism with onset by 6 months of age and variable development of antibodies to growth hormone following exogenous supplementation that has material basis in null mutations in the GH1 gene on chromosome 17q23.3.


name: SUN1_HUMAN SUN domain-containing protein 1 (sprot)

description: A SUN domain-containing protein 1 that is encoded in the genome of human.


name: P5I11_HUMAN Tumor protein p53-inducible protein 11 (sprot)

description: A tumor protein p53-inducible protein 11 that is encoded in the genome of human.


pterostilbene

A stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'.


Bloody diarrhea

description: Passage of many stools containing blood.


arketamine

The R- (less active) enantiomer of ketamine.


CASP4_HUMAN Caspase-4 (sprot)

A caspase-4 that is encoded in the genome of human.


ANLN_HUMAN Anillin (sprot)

An anillin that is encoded in the genome of human.


SEP15_HUMAN Selenoprotein F (sprot)

A selenoprotein F that is encoded in the genome of human.


name: RDH11_HUMAN Retinol dehydrogenase 11 (sprot)

description: A retinol dehydrogenase 11 that is encoded in the genome of human.


name: CAMP_HUMAN Cathelicidin antimicrobial peptide (sprot)

description: A cathelicidin antimicrobial peptide that is encoded in the genome of human.


carcinoid tumor

description: A slow growing neuroendocrine tumor, composed of uniform, round, or polygonal cells having monotonous, centrally located nuclei and small nucleoli, infrequent mitoses, and no necrosis. The tumor may show a variety of patterns, such as solid, trabecular, and acinar. Electron microscopy shows small secretory granules. Immunohistochemical studies reveal NSE, as well as chromogranin immunoreactivity. Malignant histology (cellular pleomorphism, hyperchromatic nuclei, prominent nucleoli, necrosis, and mitoses) can occasionally be seen. Such cases may have an aggressive clinical course. Gastrointestinal tract and lung are common sites of involvement.


name: neurodegeneration with brain iron accumulation

description: Neurodegeneration with brain iron accumulation (NBIA, formerly Hallervorden-Spatz syndrome) encompasses a group of rare neurodegenerative disorders characterized by progressive extrapyramidal dysfunction (dystonia, rigidity, choreoathetosis), iron accumulation in the brain and the presence of axonal spheroids, usually limited to the central nervous system.


name: TPIS_HUMAN Triosephosphate isomerase (sprot)

description: A triosephosphate isomerase that is encoded in the genome of human.


sensory ataxia

description: Any ataxia in which the causes of the disease is a perturbation of the sensory system, leading to its dysfunction.


cefapirin

A cephalosporin with  acetoxymethyl and 2(pyridin-4-ylsulfanyl)acetamido substituents at positions 3 and 7, respectively, of the cephem skeleton. It is used (as its sodium salt) as an antibiotic, being effective against gram-negative and gram-positive organisms.


name: SSBP_HUMAN Single-stranded DNA-binding protein, mitochondrial (sprot)

description: A single-stranded DNA-binding protein, mitochondrial that is encoded in the genome of human.


cinacalcet

A secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group.


name: FGF6_HUMAN Fibroblast growth factor 6 (sprot)

description: A fibroblast growth factor 6 that is encoded in the genome of human.


BUTYL ALCOHOL

A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.


name: 5HT2B_HUMAN 5-hydroxytryptamine receptor 2B (sprot)

description: A 5-hydroxytryptamine receptor 2B that is encoded in the genome of human.


name: FOXE1_HUMAN Forkhead box protein E1 (sprot)

description: A forkhead box protein E1 that is encoded in the genome of human.


ethosuximide

A  dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.


metoclopramide

A member of the class of  benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.


vestibular neuronitis

description: Idiopathic inflammation of the vestibular nerve, characterized clinically by the acute or subacute onset of vertigo; nausea; and imbalance. The cochlear nerve is typically spared and hearing loss and tinnitus do not usually occur. Symptoms usually resolve over a period of days to weeks. (Adams et al., Principles of Neurology, 6th ed, p304)


LYCORINE

An  indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it  has been shown to exhibit antimalarial activity.


name: SRY_HUMAN Sex-determining region Y protein (sprot)

description: A sex-determining region Y protein that is encoded in the genome of human.


adult T-cell leukemia/lymphoma

description: A peripheral (mature) T-cell neoplasm linked to the human T-cell leukemia virus type 1 (HTLV-1), adult T-cell leukemia/lymphoma is endemic in several regions of the world, in particular Japan, the Caribbean, and parts of Central Africa.


seborrheic infantile dermatitis

description: Excessive shedding of dry scaly material from the scalp in humans.


name: S39AC_HUMAN Zinc transporter ZIP12 (sprot)

description: A zinc transporter ZIP12 that is encoded in the genome of human.


bronchiolitis obliterans syndrome

description: A lung disorder that is mainly associated with chronic allograft dysfunction after lung transplantation and that is characterized by inflammation and fibrosis of bronchiolar walls that reduce the diameter of the bronchioles and result in progressive and irreversible airflow obstruction.


telaprevir

An oligopeptide consisting of N-(pyrazin-2-ylcarbonyl)cyclohexylalanyl, 3-methylvalyl, octahydrocyclopenta[c]pyrrole-1-carboxy, and 3-amino-N-cyclopropyl-2-oxohexanamide residues joined in sequence. Used for treatment of chronic hepatitis C virus genotype 1 infection.


description: Inflammation of the glomeruli characterized by deposits at the intraglomerular mesangium, resulting in thickening of the glomerular basement membrane, activation of complement, and impaired kidney function secondary to damaged glomeruli.


name: severe nonproliferative diabetic retinopathy


soft tissue neoplasm

description: A benign, intermediate, or malignant neoplasm that arises from the soft tissue. The most common types are lipomatous (fatty), vascular, smooth muscle, fibrous, and fibrohistiocytic neoplasms.


inamrinone

A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.


name: RIT1_HUMAN GTP-binding protein Rit1 (sprot)

description: A GTP-binding protein Rit1 that is encoded in the genome of human.


name: TBL1Y_HUMAN F-box-like/WD repeat-containing protein TBL1Y (sprot)

description: An F-box-like/WD repeat-containing protein TBL1Y that is encoded in the genome of human.


name: TRNT1_HUMAN CCA tRNA nucleotidyltransferase 1, mitochondrial (sprot)

description: A CCA tRNA nucleotidyltransferase 1, mitochondrial that is encoded in the genome of human.


primary ciliary dyskinesia

description: A rare, genetically heterogeneous, primarily respiratory disorder characterized by chronic upper and lower respiratory tract disease. Approximately half of PCD patients have an organ laterality defect (situs inversus totalis or situs ambiguus/heterotaxy).


name: BDP1_HUMAN Transcription factor TFIIIB component B'' homolog (sprot)

description: A transcription factor TFIIIB component B'' that is encoded in the genome of human.


name: RPB1_HUMAN DNA-directed RNA polymerase II subunit RPB1 (sprot)

description: A DNA-directed RNA polymerase II subunit RPB1 that is encoded in the genome of human.


name: COMD7_HUMAN COMM domain-containing protein 7 (sprot)

description: A COMM domain-containing protein 7 that is encoded in the genome of human.


name: UBP14_HUMAN Ubiquitin carboxyl-terminal hydrolase 14 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 14 that is encoded in the genome of human.


name: DP13A_HUMAN DCC-interacting protein 13-alpha (sprot)

description: A DCC-interacting protein 13-alpha that is encoded in the genome of human.


name: PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component 1 (sprot)

description: A piezo-type mechanosensitive ion channel component 1 that is encoded in the genome of human.


name: VPS52_HUMAN Vacuolar protein sorting-associated protein 52 homolog (sprot)

description: A vacuolar protein sorting-associated protein 52 that is encoded in the genome of human.


MOXIFLOXACIN HYDROCHLORIDE

A hydrochloride comprising equimolar amounts of moxifloxacin and hydrogen chloride.


phosphatidylcholine (P-37:4)

A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the unspecified alk-1-enyl and acyl groups at positions 1 and 2 contain 37 carbon atoms in total with 4 additional double bonds in the acyl moiety.


name: EIF1_HUMAN Eukaryotic translation initiation factor 1 (sprot)

description: A eukaryotic translation initiation factor 1 that is encoded in the genome of human.


name: PANK1_HUMAN Pantothenate kinase 1 (sprot)

description: A pantothenate kinase 1 that is encoded in the genome of human.


laforin, isoform 9 (human)

A laforin, isoform 9 that is encoded in the genome of human.


Neonatal hyperbilirubinemia

description: A type of hyperbilirubinemia with neonatal onset.


teratoma

description: A non-seminomatous germ cell tumor characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). It occurs in the testis, ovary, and extragonadal sites including central nervous system, mediastinum, lung, and stomach. According to the level of differentiation of the tissues which comprise the tumor, teratomas are classified as mature or immature. Mature teratomas are composed of well differentiated, adult-type tissues. Immature teratomas are composed of immature, fetal-type tissues. Testicular teratomas in children follow a benign clinical course. Mature ovarian teratomas without a fetal-type component have an excellent outcome. The prognosis of immature ovarian teratomas is related to the grade and stage of the tumor.


ACTZ_HUMAN Alpha-centractin (sprot)

An alpha-centractin that is encoded in the genome of human.


name: ABC3A_HUMAN DNA dC->dU-editing enzyme APOBEC-3A (sprot)

description: A DNA dC->dU-editing enzyme APOBEC-3A that is encoded in the genome of human.


pityriasis alba

description: A prevalent and benign dermatological condition that predominantly affects children and adolescents. The name "pityriasis alba" derives from its appearance, where "pityriasis" denotes the fine scales and "alba" signifies the pale color (hypopigmentation).


name: NKX12_HUMAN NK1 transcription factor-related protein 2 (sprot)

description: An NK1 transcription factor-related protein 2 that is encoded in the genome of human.


name: BNC1_HUMAN Zinc finger protein basonuclin-1 (sprot)

description: A zinc finger protein basonuclin-1 that is encoded in the genome of human.


CHAD_HUMAN Chondroadherin (sprot)

A chondroadherin that is encoded in the genome of human.


name: PAX4_HUMAN Paired box protein Pax-4 (sprot)

description: A paired box protein Pax-4 that is encoded in the genome of human.


OXFENICINE

The L-enantiomer of 4-hydroxyphenylglycine.


L-serine-O-phosphate

The L-enantiomer of O-phosphoserine.


novobiocin

A coumarin-derived antibiotic obtained from Streptomyces niveus.


name: AAKG2_HUMAN 5'-AMP-activated protein kinase subunit gamma-2 (sprot)

description: A 5'-AMP-activated protein kinase subunit gamma-2 that is encoded in the genome of human.


name: COE1_HUMAN Transcription factor COE1 (sprot)

description: A transcription factor COE1 that is encoded in the genome of human.


name: COBA2_HUMAN Collagen alpha-2(XI) chain (sprot)

description: A collagen alpha-2(XI) chain that is encoded in the genome of human.


name: HVCN1_HUMAN Voltage-gated hydrogen channel 1 (sprot)

description: A voltage-gated hydrogen channel 1 that is encoded in the genome of human.


gingival overgrowth

description: Excessive growth of the gingiva either by an increase in the size of the constituent cells (gingival hypertrophy) or by an increase in their number (gingival hyperplasia). (From Jablonski's Dictionary of Dentistry, 1992, p574)


TSP2_HUMAN Thrombospondin-2 (sprot)

A thrombospondin-2 that is encoded in the genome of human.


Hypopnea

description: Hypopnea is referring to breathing that is abnormally shallow.


name: ADHX_HUMAN Alcohol dehydrogenase class-3 (sprot)

description: An alcohol dehydrogenase class-3 that is encoded in the genome of human.


hydroxyzine

A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.


NPTN_HUMAN Neuroplastin (sprot)

A neuroplastin that is encoded in the genome of human.


Pediculus humanus capitis infestation

description: A infectious disease involving Pediculus humanus capitis.


tuberculosis

description: A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use.


primary hyperoxaluria

description: A hereditary disorder characterized by excessive oxalate production, leading to hyperoxaluria.


A 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol)(1-) in which the acyl group is specified as hexadecanoyl (palmitoyl); major species at pH 7.3.


TETRAHYDROCURCUMIN

A beta-diketone that is curcumin in which both of the double bonds have been reduced to single bonds.


D-serine

The R-enantiomer of serine.


name: DMPK_HUMAN Myotonin-protein kinase (sprot)

description: A myotonin-protein kinase that is encoded in the genome of human.


4-GUANIDINO-BENZOIC ACID

Benzoic acid substituted at the para position by a guanidino group.


Oligoarthritis

description: A type of arthritis that affects up to four joints in the first six months of disease.


Leber congenital amaurosis

description: Leber congenital amaurosis (LCA) is a retinal dystrophy defined by blindness and responses to electrophysiological stimulation (Ganzfeld electroretinogram (ERG)) below threshold, associated with severe visual impairment within the first year of life.


Anorgasmia

description: Inability of individual to reach orgasm.


vecuronium

A 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidino- and 16beta-N-methylpiperidinium substituents.


name: DOCK4_HUMAN Dedicator of cytokinesis protein 4 (sprot)

description: A dedicator of cytokinesis protein 4 that is encoded in the genome of human.


name: SIX1_HUMAN Homeobox protein SIX1 (sprot)

description: A homeobox protein SIX1 that is encoded in the genome of human.


CCNA1_HUMAN Cyclin-A1 (sprot)

A cyclin-A1 that is encoded in the genome of human.


SYUG_HUMAN Gamma-synuclein (sprot)

A gamma-synuclein that is encoded in the genome of human.


name: ECHP_HUMAN Peroxisomal bifunctional enzyme (sprot)

description: A peroxisomal bifunctional enzyme that is encoded in the genome of human.


name: S36A4_HUMAN Neutral amino acid uniporter 4 (sprot)

description: A neutral amino acid uniporter 4 that is encoded in the genome of human.


name: CENPE_HUMAN Centromere-associated protein E (sprot)

description: A centromere-associated protein E that is encoded in the genome of human.


name: AHR_HUMAN Aryl hydrocarbon receptor (sprot)

description: An aryl hydrocarbon receptor that is encoded in the genome of human.


name: therapy related acute myeloid leukemia and myelodysplastic syndrome

description: An acute myeloid leukemia secondary to a myelodysplastic syndrome or therapy-related. (WHO, 2001)


name: S25A3_HUMAN Solute carrier family 25 member 3 (sprot)

description: A solute carrier family 25 member 3 that is encoded in the genome of human.


name: SOX21_HUMAN Transcription factor SOX-21 (sprot)

description: A transcription factor SOX-21 that is encoded in the genome of human.


name: SOX3_HUMAN Transcription factor SOX-3 (sprot)

description: A transcription factor SOX-3 that is encoded in the genome of human.


name: CC14A_HUMAN Dual specificity protein phosphatase CDC14A (sprot)

description: A dual specificity protein phosphatase CDC14A that is encoded in the genome of human.


Lambert-Eaton myasthenic syndrome

description: Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune, presynaptic disorder of neuromuscular transmission characterized by fluctuating muscle weakness and autonomic dysfunction frequently associated with small-cell lung cancer (SCLC).


name: GPS2_HUMAN G protein pathway suppressor 2 (sprot)

description: A G protein pathway suppressor 2 that is encoded in the genome of human.


alcoholic liver cirrhosis

description: A disorder of the liver characterized by the presence of fibrotic scar tissue instead of healthy liver tissue. This condition is attributed to excessive consumption of alcoholic beverages.


isolated cleft palate

description: A cleft palate that is not part of a larger syndrome.


name: HCP5_HUMAN HLA class I histocompatibility antigen protein P5 (sprot)

description: An MHC class I histocompatibility antigen protein P5 that is encoded in the genome of human.


name: KCNH2_HUMAN Potassium voltage-gated channel subfamily H member 2 (sprot)

description: A voltage-gated potassium channel KCNH2 that is encoded in the genome of human.


canine melanoma

description: Melanoma occurring in a dog. It is the most common malignant tumor found in the mouths of dogs and also occurs frequently on the digits. All canine melanomas are locally invasive and malignant canine melanomas show a high rate of metastasis. Melanoma in dogs has been established as a relevant model for human melanoma.


name: CHAP1_HUMAN Chromosome alignment-maintaining phosphoprotein 1 (sprot)

description: A zinc finger protein 828 that is encoded in the genome of human.


L-methionine (R)-S-oxide

The (R)-oxido diastereomer of L-methionine S-oxide.


A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'.


name: WASP_HUMAN Actin nucleation-promoting factor WAS (sprot)

description: An actin nucleation-promoting factor WAS that is encoded in the genome of human.


name: DICER_HUMAN Endoribonuclease Dicer (sprot)

description: An endoribonuclease Dicer that is encoded in the genome of human.


name: UBL4A_HUMAN Ubiquitin-like protein 4A (sprot)

description: A ubiquitin-like protein 4A that is encoded in the genome of human.


CAH6_HUMAN Carbonic anhydrase 6 (sprot)

A carbonic anhydrase 6 that is encoded in the genome of human.


name: MMP25_HUMAN Matrix metalloproteinase-25 (sprot)

description: A matrix metalloproteinase-25 that is encoded in the genome of human.


trimethadione

An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by methyl groups at positions 3, 5 and 5. It is an antiepileptic agent.


Lennox-Gastaut syndrome

description: Lennox-Gastaut syndrome (LGS) belongs to the group of severe childhood epileptic encephalopathies.


name: LCAP_HUMAN Leucyl-cystinyl aminopeptidase (sprot)

description: A leucyl-cystinyl aminopeptidase that is encoded in the genome of human.


name: PELI3_HUMAN E3 ubiquitin-protein ligase pellino homolog 3 (sprot)

description: An E3 ubiquitin-protein ligase pellino homolog 3 that is encoded in the genome of human.


name: RL39_HUMAN Large ribosomal subunit protein eL39 (sprot)

description: A large ribosomal subunit protein eL39 that is encoded in the genome of human.


CP2C8_HUMAN Cytochrome P450 2C8 (sprot)

A cytochrome P450 2C8 that is encoded in the genome of human.


phosphatidylinositol (18:0/18:1)

A phosphatidylinositol 36:1 in which the acyl group at position 1 contains 18 carbons and no double bonds while that at position 2 contains 18 carbons and 1 double bond.


male infertility

description: The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility.


hypogonadism

description: A disorder characterized by decreased function of the gonads. Clinical manifestations in both males and females include poor libido, infertility, and osteoporosis. Additional signs in males include erectile dysfunction, muscle atrophy, gynecomastia and increased abdominal fat. In females, additional signs include shrinking of the breasts and loss of, or failure to develop menstruation.


name: TRBP2_HUMAN RISC-loading complex subunit TARBP2 (sprot)

description: A RISC-loading complex subunit TARBP2 that is encoded in the genome of human.


STC2_HUMAN Stanniocalcin-2 (sprot)

A stanniocalcin-2 that is encoded in the genome of human.


name: ZC12A_HUMAN Endoribonuclease ZC3H12A (sprot)

description: An endoribonuclease ZC3H12A that is encoded in the genome of human.


name: PHF13_HUMAN PHD finger protein 13 (sprot)

description: A PHD finger protein 13 that is encoded in the genome of human.


hemophilia B

description: Hemophilia B is a form of hemophilia characterized by spontaneous or prolonged hemorrhages due to factor IX deficiency.


ATPGAMMAS

A nucleoside triphosphate analogue that is ATP in which one of the oxygens attached to 3-phosphate group is replaced by sulfur.


name: AKIP1_HUMAN A-kinase-interacting protein 1 (sprot)

description: A proline-rich protein BCA3 that is encoded in the genome of human.


sodium aurothiomalate

An organic sodium salt which is the disodium salt of gold thiomalic acid, with a basic unit comprising two sodium cations and a divalent aurothiomalate anion.


abiraterone

A 3beta-sterol that is androsta-5,16-dien-3beta-ol substituted at position 17 by a 3-pyridyl group. Administered as the O-acetate, it is used for treatment of metastatic castrate-resistant prostate cancer.


phosphatidylglycerol (16:0/19:1)

A phosphatidylglycerol 35:1 in which the acyl group at C-1 contains 16 carbons and no double bonds while that at C-2 contains 19 carbons and 1 double bond.


myxofibrosarcoma

description: A malignant fibroblastic neoplasm arising from the soft tissue. It is characterized by the presence of spindle-shaped cells, cellular pleomorphism, thin-walled blood vessels, fibrous septa, and myxoid stroma.


phenothiazine

The 10H-tautomer of phenothiazine.


name: SL2A8_HUMAN Solute carrier family 2, facilitated glucose transporter member 8 (sprot)

description: A solute carrier family 2, facilitated glucose transporter member 8 that is encoded in the genome of human.


lymphangioleiomyomatosis

description: A multifocal neoplasm with perivascular epithelioid cell differentiation affecting almost exclusively females of child-bearing age. It is characterized by the presence of smooth muscle and epithelioid cells and by the proliferation of lymphatic vessels. Sites of involvement include the lungs, mediastinum, and the retroperitoneum. It usually presents with chylous pleural effusion or ascites.


CCNG2_HUMAN Cyclin-G2 (sprot)

A cyclin-G2 that is encoded in the genome of human.


TOR3A_HUMAN Torsin-3A (sprot)

A torsin-3A that is encoded in the genome of human.


name: PAQR1_HUMAN Adiponectin receptor protein 1 (sprot)

description: An adiponectin receptor protein 1 that is encoded in the genome of human.


phosphatidylserine (20:4/20:4)

A phosphatidyl-L-serine in which both acyl groups have 20 carbons and 4 double bonds.


name: HHIP_HUMAN Hedgehog-interacting protein (sprot)

description: A hedgehog-interacting protein that is encoded in the genome of human.


name: DBF4A_HUMAN Protein DBF4 homolog A (sprot)

description: A protein DBF4 homolog A that is encoded in the genome of human.


name: RAD18_HUMAN E3 ubiquitin-protein ligase RAD18 (sprot)

description: An E3 ubiquitin-protein ligase RAD18 that is encoded in the genome of human.


name: PEN2_HUMAN Gamma-secretase subunit PEN-2 (sprot)

description: A gamma-secretase subunit PEN-2 that is encoded in the genome of human.


TSN33_HUMAN Tetraspanin-33 (sprot)

A tetraspanin-33 that is encoded in the genome of human.


invasive lobular breast carcinoma

description: An infiltrating lobular adenocarcinoma of the breast. The malignant cells lack cohesion and are arranged individually or in a linear manner (Indian files), or as narrow trabeculae within the stroma. The malignant cells are usually smaller than those of ductal carcinoma, are less pleomorphic, and have fewer mitotic figures.


name: PPM1A_HUMAN Protein phosphatase 1A (sprot)

description: A protein phosphatase 1A that is encoded in the genome of human.


name: KDM3A_HUMAN Lysine-specific demethylase 3A (sprot)

description: A lysine-specific demethylase 3A that is encoded in the genome of human.


benzalkonium

A quaternary ammonium ion obtained by methylation of N-benzyl-N-methyldodecan-1-amine.


name: CLPB_HUMAN Mitochondrial disaggregase (sprot)

description: A caseinolytic peptidase B protein that is encoded in the genome of human.


rofecoxib

A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.


1-naphthaleneacetic acid

A naphthylacetic acid substituted by a carboxymethyl group at position 1.


name: AK1BA_HUMAN Aldo-keto reductase family 1 member B10 (sprot)

description: An aldo-keto reductase family 1 member B10 that is encoded in the genome of human.


name: VGLU1_HUMAN Vesicular glutamate transporter 1 (sprot)

description: A vesicular glutamate transporter 1 that is encoded in the genome of human.


name: UBAP1_HUMAN Ubiquitin-associated protein 1 (sprot)

description: A ubiquitin-associated protein 1 that is encoded in the genome of human.


name: UFM1_HUMAN Ubiquitin-fold modifier 1 (sprot)

description: A ubiquitin-fold modifier 1 that is encoded in the genome of human.


CAD23_HUMAN Cadherin-23 (sprot)

A cadherin-23 that is encoded in the genome of human.


phosphatidylcholine (20:4/20:5)

A phosphatidylcholine 40:9 in which the fatty acyl groups at positions 1 and 2 are specified as C20:4 and C20:5 respectively.


diacylglycerol (18:0/20:3/0:0)

A 1,2-diglyceride in which the fatty acyl groups at positions 1 and 2 are specified as C18:0 and C20:3 respectively.


saccharin

A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.


Chronic colitis

description: A chronic inflammatory disease of the large intestine (colon, cecum and rectum).


name: EYA1_HUMAN Eyes absent homolog 1 (sprot)

description: An eyes absent homolog 1 that is encoded in the genome of human.


NXN_HUMAN Nucleoredoxin (sprot)

A nucleoredoxin that is encoded in the genome of human.


codeine

A  morphinane alkaloid found in the opium poppy, Papaver somniferum var. album; has analgesic, anti-tussive and anti-diarrhoeal properties.


name: S4A5_HUMAN Electrogenic sodium bicarbonate cotransporter 4 (sprot)

description: An electrogenic sodium bicarbonate cotransporter 4 that is encoded in the genome of human.


SYT9_HUMAN Synaptotagmin-9 (sprot)

A synaptotagmin-9 that is encoded in the genome of human.


name: IF6_HUMAN Eukaryotic translation initiation factor 6 (sprot)

description: A eukaryotic translation initiation factor 6 that is encoded in the genome of human.


A pyridinium ion comprising nicotinamide having a methyl group at the 1-position. It is a metabolite of nicotinamide which was initially considered to be biologically inactive but has emerged as an anti-thrombotic and anti-inflammatory agent.


name: MGST3_HUMAN Glutathione S-transferase 3, mitochondrial (sprot)

description: A glutathione S-transferase 3, mitochondrial that is encoded in the genome of human.


name: 5HT3A_HUMAN 5-hydroxytryptamine receptor 3A (sprot)

description: A 5-hydroxytryptamine receptor 3A that is encoded in the genome of human.


NET1_HUMAN Netrin-1 (sprot)

A netrin-1 that is encoded in the genome of human.


SAP_HUMAN Prosaposin (sprot)

A prosaposin that is encoded in the genome of human.


benzydamine

A member of the class of indazoles carrying benzyl and 3-(dimethylamino)propyl groups at positions 1 and 3 respectively. A locally-acting nonsteroidal anti-inflammatory drug that also exhibits local anaesthetic and analgesic properties.


cervical squamous cell carcinoma

description: A squamous cell carcinoma arising from the cervical epithelium. It usually evolves from a precancerous cervical lesion. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors for cervical squamous cell carcinoma. The following histologic patterns have been described: conventional squamous cell carcinoma, papillary squamous cell carcinoma, transitional cell carcinoma, lymphoepithelioma-like carcinoma, verrucous carcinoma, condylomatous carcinoma and spindle cell carcinoma. Survival is most closely related to the stage of disease at the time of diagnosis.


ventricular tachycardia

description: A disorder characterized by an electrocardiographic finding of three or more consecutive complexes of ventricular origin with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC)


phosphatidylcholine (16:0/23:5)

A phosphatidylcholine 39:5 in which the fatty acyl groups at positions 1 and 2 are specified as C16:0 and C23:5 respectively.


name: CPNS1_HUMAN Calpain small subunit 1 (sprot)

description: A calpain small subunit 1 that is encoded in the genome of human.


name: CPNS2_HUMAN Calpain small subunit 2 (sprot)

description: A calpain small subunit 2 that is encoded in the genome of human.


name: CLCF1_HUMAN Cardiotrophin-like cytokine factor 1 (sprot)

description: A cardiotrophin-like cytokine factor 1 that is encoded in the genome of human.


name: PA24A_HUMAN Cytosolic phospholipase A2 (sprot)

description: A cytosolic phospholipase A2 that is encoded in the genome of human.


name: PSD11_HUMAN 26S proteasome non-ATPase regulatory subunit 11 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 11 that is encoded in the genome of human.


meldonium

An ammonium betaine that is beta-alaninate in which one of the amino hydrogens is replaced by a trimethylamino group. A clinically used cardioprotective drug that is used for treatment of heart failure, myocardial infarction, arrhythmia, atherosclerosis and diabetes.


name: CD72_HUMAN B-cell differentiation antigen CD72 (sprot)

description: A CD72 molecule that is encoded in the genome of human.


name: K2C4_HUMAN Keratin, type II cytoskeletal 4 (sprot)

description: A keratin, type II cytoskeletal 4 that is encoded in the genome of human.


name: TRI59_HUMAN Tripartite motif-containing protein 59 (sprot)

description: A tripartite motif-containing protein 59 that is encoded in the genome of human.


titanium dioxide

A titanium oxide with the formula TiO2.  A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.


Spasticity

description: A motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes.


name: AMRA1_HUMAN Activating molecule in BECN1-regulated autophagy protein 1 (sprot)

description: An activating molecule in BECN1-regulated autophagy protein 1 that is encoded in the genome of human.


name: GNDS_HUMAN Ral guanine nucleotide dissociation stimulator (sprot)

description: A Ral guanine nucleotide dissociation stimulator that is encoded in the genome of human.


phosphatidylethanolamine (18:0/19:1)

A phosphatidylethanolamine 37:1 in which the acyl group at C-1 contains 18 carbons and no double bonds while that at C-2 contains 19 carbons and 1 double bond.


name: AT8A1_HUMAN Phospholipid-transporting ATPase IA (sprot)

description: A phospholipid-transporting ATPase IA that is encoded in the genome of human.


name: RHG05_HUMAN Rho GTPase-activating protein 5 (sprot)

description: A Rho GTPase-activating protein 5 that is encoded in the genome of human.


Mild proteinuria

description: Mildly increased levels of protein in the urine (150-500 mg per day in adults).


ependymoma

description: A WHO grade II, slow growing tumor of children and young adults, usually located intraventricularly. It is the most common ependymal neoplasm. It often causes clinical symptoms by blocking cerebrospinal fluid pathways. Key histological features include perivascular pseudorosettes and ependymal rosettes. (WHO)


bergapten

A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5.


gluconic acid

A gluconic acid having D-configuration.


name: HSBP1_HUMAN Heat shock factor-binding protein 1 (sprot)

description: A heat shock factor-binding protein 1 that is encoded in the genome of human.


name: NPRL2_HUMAN GATOR1 complex protein NPRL2 (sprot)

description: A GATOR1 complex protein NPRL2 that is encoded in the genome of human.


A dinitrophenol having the nitro groups at the 2- and 4-positions.


cefixime

A third-generation cephalosporin antibiotic bearing vinyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used in the treatment of gonorrhoea, tonsilitis, pharyngitis, bronchitis, and urinary tract infections.


ELNE_HUMAN Neutrophil elastase (sprot)

A neutrophil elastase that is encoded in the genome of human.


SORCN_HUMAN Sorcin (sprot)

A sorcin that is encoded in the genome of human.


monobenzone

The monobenzyl ether of hydroquinone.  It is used as a topical drug for medical depigmentation.


name: CCL13_HUMAN C-C motif chemokine 13 (sprot)

description: A C-C motif chemokine 13 that is encoded in the genome of human.


name: anti-neutrophil cytoplasmic antibody-associated vasculitis

description: Group of systemic vasculitis with a strong association with anca. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls.


name: HECW2_HUMAN E3 ubiquitin-protein ligase HECW2 (sprot)

description: An E3 ubiquitin-protein ligase HECW2 that is encoded in the genome of human.


CCNC_HUMAN Cyclin-C (sprot)

A cyclin-C that is encoded in the genome of human.


name: TRPC7_HUMAN Short transient receptor potential channel 7 (sprot)

description: A short transient receptor potential cation channel TRPC7 that is encoded in the genome of human.


name: ACV1B_HUMAN Activin receptor type-1B (sprot)

description: An activin receptor type-1B that is encoded in the genome of human.


name: ACON_HUMAN Aconitate hydratase, mitochondrial (sprot)

description: An aconitate hydratase, mitochondrial that is encoded in the genome of human.


clindamycin

A carbohydrate-containing antibiotic that is the  semisynthetic derivative of lincomycin, a natural antibiotic.


name: ZNT3_HUMAN Probable proton-coupled zinc antiporter SLC30A3 (sprot)

description: A probable proton-coupled zinc antiporter SLC30A3 that is encoded in the genome of human.


name: ZNT2_HUMAN Proton-coupled zinc antiporter SLC30A2 (sprot)

description: A proton-coupled zinc antiporter SLC30A2 that is encoded in the genome of human.


name: 5HT2C_HUMAN 5-hydroxytryptamine receptor 2C (sprot)

description: A 5-hydroxytryptamine receptor 2C that is encoded in the genome of human.


pleural mesothelioma

description: A neoplasm that arises from the mesothelial cells of the pleura. The primary cause is exposure to asbestos. The major histologic variants are the epithelioid malignant mesothelioma, desmoplastic malignant mesothelioma, and sarcomatoid malignant mesothelioma. Patients present with persistent cough and shortness of breath.


INSL3_HUMAN Insulin-like 3 (sprot)

An insulin-like 3 that is encoded in the genome of human.


HYALP_HUMAN Hyaluronidase PH-20 (sprot)

A hyaluronidase PH-20 that is encoded in the genome of human.


name: NFYB_HUMAN Nuclear transcription factor Y subunit beta (sprot)

description: A nuclear transcription factor Y subunit beta that is encoded in the genome of human.


Dysphonia

description: Difficulty in speaking due to a physical disorder of the mouth, tongue, throat, or vocal cords. Associated with a known physical or neurological cause.


name: STAT2_HUMAN Signal transducer and activator of transcription 2 (sprot)

description: A signal transducer and activator of transcription 2 that is encoded in the genome of human.


name: TCAB1_HUMAN Telomerase Cajal body protein 1 (sprot)

description: A telomerase Cajal body protein 1 that is encoded in the genome of human.


CPNE3_HUMAN Copine-3 (sprot)

A copine-3 that is encoded in the genome of human.


name: GDIR3_HUMAN Rho GDP-dissociation inhibitor 3 (sprot)

description: A Rho GDP-dissociation inhibitor 3 that is encoded in the genome of human.


name: ELK3_HUMAN ETS domain-containing protein Elk-3 (sprot)

description: An ETS domain-containing protein Elk-3 that is encoded in the genome of human.


name: UBR1_HUMAN E3 ubiquitin-protein ligase UBR1 (sprot)

description: An E3 ubiquitin-protein ligase UBR1 that is encoded in the genome of human.


name: PRR13_HUMAN Proline-rich protein 13 (sprot)

description: A proline-rich protein 13 that is encoded in the genome of human.


description: X-linked intellectual disability-macrocephaly-macroorchidism syndrome is characterized by intellectual deficit affecting both sexes, macrocephaly, and macroorchidism in the majority of affected males. It has been described in 12 individuals from two generations of one family. Other males from this family did not display intellectual deficit but did present macroorchidism and macrocephaly. Transmission is X-linked and the causative gene has been localized to the q12-q21 region of the X chromosome.


saxagliptin

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes.


adenoid cystic carcinoma

description: A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid cystic carcinomas mostly occur in the salivary glands. Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread is characteristic.


name: ADA12_HUMAN Disintegrin and metalloproteinase domain-containing protein 12 (sprot)

description: A disintegrin and metalloproteinase domain-containing protein 12 that is encoded in the genome of human.


Gait ataxia

description: A type of ataxia characterized by the impairment of the ability to coordinate the movements required for normal walking. Gait ataxia is characteirzed by a wide-based staggering gait with a tendency to fall.


name: TOPB1_HUMAN DNA topoisomerase 2-binding protein 1 (sprot)

description: A DNA topoisomerase 2-binding protein 1 that is encoded in the genome of human.


name: NOA1_HUMAN Nitric oxide-associated protein 1 (sprot)

description: A nitric oxide-associated protein 1 that is encoded in the genome of human.


name: TYB4Y_HUMAN Thymosin beta-4, Y-chromosomal (sprot)

description: A thymosin beta-4, Y-chromosomal that is encoded in the genome of human.


mefenamic acid

An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.


name: CNDP2_HUMAN Cytosolic non-specific dipeptidase (sprot)

description: A cytosolic non-specific dipeptidase that is encoded in the genome of human.


imidacloprid

The E-isomer of imidacloprid.


name: DUS5_HUMAN Dual specificity protein phosphatase 5 (sprot)

description: A dual specificity protein phosphatase 5 that is encoded in the genome of human.


name: MCP_HUMAN Membrane cofactor protein (sprot)

description: A membrane cofactor protein that is encoded in the genome of human.


Cardiac conduction abnormality

description: Any anomaly of the progression of electrical impulses through the heart.


name: BASP1_HUMAN Brain acid soluble protein 1 (sprot)

description: A brain acid soluble protein 1 that is encoded in the genome of human.


IgA glomerulonephritis

description: Inflammation of a specific segment of glomeruli within the kidney.


ABI2_HUMAN Abl interactor 2 (sprot)

An Abl interactor 2 that is encoded in the genome of human.


tolcapone

Benzophenone substituted on one of the phenyl rings at C-3 and C-4 by hydroxy groups and at C-5 by a nitro group, and on the other phenyl ring by a methyl group at C-4. It is an inhibitor of catechol O-methyltransferase.


name: FXL21_HUMAN Putative F-box/LRR-repeat protein 21 (sprot)

description: A putative F-box/LRR-repeat protein 21 that is encoded in the genome of human.


name: FBXL3_HUMAN F-box/LRR-repeat protein 3 (sprot)

description: An F-box/LRR-repeat protein 3 that is encoded in the genome of human.


name: IDH3A_HUMAN Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (sprot)

description: An isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial that is encoded in the genome of human.


name: ELF2_HUMAN ETS-related transcription factor Elf-2 (sprot)

description: An ETS-related transcription factor Elf-2 that is encoded in the genome of human.


TICN3_HUMAN Testican-3 (sprot)

A testican-3 that is encoded in the genome of human.


name: ANF_HUMAN Natriuretic peptides A (sprot)

description: An atrial natriuretic factor that is encoded in the genome of human.


The 5alpha-stereoisomer of androstane-3,17-dione.


malic acid

A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.


SOMA_HUMAN Somatotropin (sprot)

A somatotropin that is encoded in the genome of human.


name: FOLC_HUMAN Folylpolyglutamate synthase, mitochondrial (sprot)

description: A folylpolyglutamate synthase, mitochondrial that is encoded in the genome of human.


name: MBOA5_HUMAN Lysophospholipid acyltransferase 5 (sprot)

description: A lysophospholipid acyltransferase 5 that is encoded in the genome of human.


name: T22D3_HUMAN TSC22 domain family protein 3 (sprot)

description: A TSC22 domain family protein 3 that is encoded in the genome of human.


phosphatidylethanolamine (18:0/22:6)

A phosphatidylethanolamine in which one acyl group has 18 carbons and is fully saturated while the other has 22 carbons and 6 double bonds.


menadione

A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.


large cell neuroendocrine carcinoma

description: A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.


renal carcinoma

description: A carcinoma arising from the epithelium of the renal parenchyma or the renal pelvis. The majority are renal cell carcinomas. Kidney carcinomas usually affect middle aged and elderly adults. Hematuria, abdominal pain, and a palpable mass are common symptoms.


HEMO_HUMAN Hemopexin (sprot)

A hemopexin that is encoded in the genome of human.


name: KSYK_HUMAN Tyrosine-protein kinase SYK (sprot)

description: A tyrosine-protein kinase SYK that is encoded in the genome of human.


name: TRPM8_HUMAN Transient receptor potential cation channel subfamily M member 8 (sprot)

description: A transient receptor potential cation channel TRPM8 that is encoded in the genome of human.


CRNN_HUMAN Cornulin (sprot)

A cornulin that is encoded in the genome of human.


name: WFDC2_HUMAN WAP four-disulfide core domain protein 2 (sprot)

description: A WAP four-disulfide core domain protein 2 that is encoded in the genome of human.


name: AL1A2_HUMAN Retinal dehydrogenase 2 (sprot)

description: A retinal dehydrogenase 2 that is encoded in the genome of human.


name: GPAT2_HUMAN Glycerol-3-phosphate acyltransferase 2, mitochondrial (sprot)

description: A glycerol-3-phosphate acyltransferase 2, mitochondrial that is encoded in the genome of human.


PLSL_HUMAN Plastin-2 (sprot)

A plastin-2 that is encoded in the genome of human.


name: KAP2_HUMAN cAMP-dependent protein kinase type II-alpha regulatory subunit (sprot)

description: A cAMP-dependent protein kinase type II-alpha regulatory subunit that is encoded in the genome of human.


N-oleoylethanolamide

An N-(long-chain-acyl)ethanolamine that is the ethanolamide of oleic acid. The monounsaturated analogue of the endocannabinoid anandamide.


androstenedione

A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.


IL20_HUMAN Interleukin-20 (sprot)

An interleukin-20 that is encoded in the genome of human.


multifocal motor neuropathy

description: Multifocal motor neuropathy (MMN) is a rare acquired immune-mediatedneuropathy characterized clinically by a purely motor deficit with conduction block and asymmetric multifocal weakness, fasciculations, and cramping.


name: TMED3_HUMAN Transmembrane emp24 domain-containing protein 3 (sprot)

description: A transmembrane emp24 domain-containing protein 3 that is encoded in the genome of human.


phosphatidylcholine (16:1/20:4)

A phosphatidylcholine 36:5 in which the fatty acyl groups at positions 1 and 2 are specified as C16:1 and C20:4 respectively.


name: PSMD5_HUMAN 26S proteasome non-ATPase regulatory subunit 5 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 5 that is encoded in the genome of human.


kanamycin

Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.


name: EYA3_HUMAN Eyes absent homolog 3 (sprot)

description: An eyes absent homolog 3 that is encoded in the genome of human.


name: SIX5_HUMAN Homeobox protein SIX5 (sprot)

description: A homeobox protein SIX5 that is encoded in the genome of human.


obstructive lung disease

description: Any disorder marked by obstruction of conducting airways of the lung. airway obstruction may be acute, chronic, intermittent, or persistent.


thyroid gland papillary carcinoma

description: A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. Radiation exposure is a risk factor and it is the most common malignant thyroid lesion, comprising 75% to 80% of all thyroid cancers in iodine sufficient countries. Diagnostic procedures include thyroid ultrasound and fine needle biopsy. Microscopically, the diagnosis is based on the distinct characteristics of the malignant cells, which include enlargement, oval shape, elongation, and overlapping of the nuclei. The nuclei also display clearing or have a ground glass appearance.


name: PKHA8_HUMAN Pleckstrin homology domain-containing family A member 8 (sprot)

description: A pleckstrin homology domain-containing family A member 8 that is encoded in the genome of human.


name: SHAN2_HUMAN SH3 and multiple ankyrin repeat domains protein 2 (sprot)

description: An SH3 and multiple ankyrin repeat domains protein 2 that is encoded in the genome of human.


name: RFC4_HUMAN Replication factor C subunit 4 (sprot)

description: A replication factor C subunit 4 that is encoded in the genome of human.


Hypernatremia

description: An abnormally increased sodium concentration in the blood.


name: CD244_HUMAN Natural killer cell receptor 2B4 (sprot)

description: A natural killer cell receptor 2B4 that is encoded in the genome of human.


alpha-methyltyrosine

An L-tyrosine derivative that consists of L-tyrosine bearing an additional methyl substituent at position 2. An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma.


name: CHM4B_HUMAN Charged multivesicular body protein 4b (sprot)

description: A charged multivesicular body protein 4b that is encoded in the genome of human.


name: HUS1_HUMAN Checkpoint protein HUS1 (sprot)

description: A checkpoint protein HUS1 that is encoded in the genome of human.


angioedema

description: Swelling involving the deep dermis, subcutaneous, or submucosal tissues, representing localized edema. Angioedema often occurs in the face, lips, tongue, and larynx.


name: RARB_HUMAN Retinoic acid receptor beta (sprot)

description: A retinoic acid receptor beta that is encoded in the genome of human.


name: RGS9_HUMAN Regulator of G-protein signaling 9 (sprot)

description: A regulator of G-protein signaling 9 that is encoded in the genome of human.


name: ZBT11_HUMAN Zinc finger and BTB domain-containing protein 11 (sprot)

description: A zinc finger and BTB domain-containing protein 11 that is encoded in the genome of human.


vanillate

A methoxybenzoate that is the conjugate base of vanillic acid.


Pollakisuria

description: Increased frequency of urination.


ADDG_HUMAN Gamma-adducin (sprot)

A gamma-adducin that is encoded in the genome of human.


name: GSG1_HUMAN Germ cell-specific gene 1 protein (sprot)

description: A germ cell-specific gene 1 protein that is encoded in the genome of human.


peripheral ischemia

description: Deficient blood distribution to the limbs caused by narrowing or obstruction of the lumen of the peripheral arteries.


name: ANPRA_HUMAN Atrial natriuretic peptide receptor 1 (sprot)

description: An atrial natriuretic peptide receptor 1 that is encoded in the genome of human.


bladder carcinoma in situ

description: Also known as carcinoma in situ of the urinary bladder or high grade intraurothelial neoplasia, this is a flat lesion of the transitional cell epithelium characterized by severe cytologic atypia. This lesion is confined to the urothelium, and is a precursor of invasive transitional cell carcinoma of the bladder. Stage 0is includes: Tis, N0, M0. Tis: Carcinoma in situ: "flat tumor". N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: VRK3_HUMAN Serine/threonine-protein kinase VRK3 (sprot)

description: An inactive serine/threonine-protein kinase VRK3 that is encoded in the genome of human.


name: NSUN2_HUMAN RNA cytosine C(5)-methyltransferase NSUN2 (sprot)

description: An RNA cytosine C(5)-methyltransferase NSUN2 that is encoded in the genome of human.


pentostatin

A member of the class of coformycins that is coformycin in which the hydroxy group at position 2' is replaced with a hydrogen. It is a drug used for the treatment of hairy cell leukaemia.


cefamandole

A cephalosporin compound having (R)-mandelamido and N-methylthiotetrazole side-groups.


sarcoidosis

description: Sarcoidosis is a multisystemic disorder of unknown cause characterized by the formation of immune granulomas in involved organs.


ANK3_HUMAN Ankyrin-3 (sprot)

An ankyrin-3 that is encoded in the genome of human.


aminophenazone

A  pyrazolone  that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.


NET4_HUMAN Netrin-4 (sprot)

A netrin-4 that is encoded in the genome of human.


name: TIRAP_HUMAN Toll/interleukin-1 receptor domain-containing adapter protein (sprot)

description: A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of human.


name: RN216_HUMAN E3 ubiquitin-protein ligase RNF216 (sprot)

description: An E3 ubiquitin-protein ligase RNF216 that is encoded in the genome of human.


name: BAG4_HUMAN BAG family molecular chaperone regulator 4 (sprot)

description: A BAG family molecular chaperone regulator 4 that is encoded in the genome of human.


DOK2_HUMAN Docking protein 2 (sprot)

A docking protein 2 that is encoded in the genome of human.


name: CXL14_HUMAN C-X-C motif chemokine 14 (sprot)

description: A C-X-C motif chemokine 14 that is encoded in the genome of human.


name: MDFI_HUMAN MyoD family inhibitor (sprot)

description: A MyoD family inhibitor that is encoded in the genome of human.


name: CCL23_HUMAN C-C motif chemokine 23 (sprot)

description: A C-C motif chemokine 23 that is encoded in the genome of human.


name: AAKG1_HUMAN 5'-AMP-activated protein kinase subunit gamma-1 (sprot)

description: A 5'-AMP-activated protein kinase subunit gamma-1 that is encoded in the genome of human.


Felty syndrome

description: Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections.


name: ADCYA_HUMAN Adenylate cyclase type 10 (sprot)

description: An adenylate cyclase type 10 that is encoded in the genome of human.


mucocutaneous lymph node syndrome

description: Kawasaki disease (KD) is a febrile, systemic, self-limiting vasculitis affecting children and characterized by inflammation in the medium sized vessels associated with coronary arterial aneurysms (CAA) that may be life threatening when untreated. KD is the most common cause of acquired heart disease in children in developed countries and is a risk factor for ischemic heart disease in adulthood.


name: MAT2B_HUMAN Methionine adenosyltransferase 2 subunit beta (sprot)

description: A methionine adenosyltransferase 2 subunit beta that is encoded in the genome of human.


name: EAF1_HUMAN ELL-associated factor 1 (sprot)

description: An ELL-associated factor 1 that is encoded in the genome of human.


fluticasone furoate

A trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a 2-furoyl substituent at position 17. Used in combination with vilanterol trifenate for treatment of bronchospasm associated with chronic obstructive pulmonary disease.


ceritinib

A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(piperidin-4-yl)-5-methylphenyl and 2-(isopropylsulfonyl)phenyl substituents. Used for the treatment of ALK-positive metastatic non-small cell lung cancer.


name: ZBP1_HUMAN Z-DNA-binding protein 1 (sprot)

description: A Z-DNA-binding protein 1 that is encoded in the genome of human.


name: TIMP4_HUMAN Metalloproteinase inhibitor 4 (sprot)

description: A metalloproteinase inhibitor 4 that is encoded in the genome of human.


name: TMM64_HUMAN Transmembrane protein 64 (sprot)

description: A transmembrane protein 64 that is encoded in the genome of human.


name: EEIG2_HUMAN EEIG family member 2 (sprot)

description: An EEIG family member 2 that is encoded in the genome of human.


FILA2_HUMAN Filaggrin-2 (sprot)

A filaggrin-2 that is encoded in the genome of human.


name: GPX7_HUMAN Glutathione peroxidase 7 (sprot)

description: A glutathione peroxidase 7 that is encoded in the genome of human.


name: NUD16_HUMAN U8 snoRNA-decapping enzyme (sprot)

description: A U8 snoRNA-decapping enzyme that is encoded in the genome of human.


name: MAGE2_HUMAN Melanoma-associated antigen E2 (sprot)

description: A melanoma-associated antigen E2 that is encoded in the genome of human.


vasculitis due to ADA2 deficiency

description: Vasculitis due to ADA2 deficiency is a rare, genetic, systemic and rheumatologic disease due to adenosine deaminase-2 inactivating mutations, combining variable features of autoinflammation, vasculitis, and a mild immunodeficiency. Variable clinical presentation includes chronic or recurrent systemic inflammation with fever, livedo reticularis or racemosa, early-onset ischemic or hemorrhagic strokes, peripheral neuropathy, abdominal pain, hepatosplenomegaly, portal hypertension, cutaneous polyarteritis nodosa, variable cytopenia and immunoglobulin deficiency.


name: TEX10_HUMAN Testis-expressed protein 10 (sprot)

description: A testis-expressed protein 10 that is encoded in the genome of human.


name: IOD2_HUMAN Type II iodothyronine deiodinase (sprot)

description: A type II iodothyronine deiodinase that is encoded in the genome of human.


FDFT_HUMAN Squalene synthase (sprot)

A squalene synthase that is encoded in the genome of human.


acute cholecystitis

description: Acute inflammation of the gallbladder.


name: SYLM_HUMAN Leucine--tRNA ligase, mitochondrial (sprot)

description: A leucine--tRNA ligase, mitochondrial that is encoded in the genome of human.


IL19_HUMAN Interleukin-19 (sprot)

An interleukin-19 that is encoded in the genome of human.


dihydromyricetin

A hexahydroxyflavanone that is the 2,3-dihydro derivative of myricetin.


name: GOGA5_HUMAN Golgin subfamily A member 5 (sprot)

description: A golgin subfamily A member 5 that is encoded in the genome of human.


brivaracetam

A non-proteinogenic amino acid derivative that is butanamide in which the pro-S hydrogen at position 2 is replaced by a (4R)-2-oxo-4-propylpyrrolidin-1-yl. Used for treatment of partial onset seizures related to epilepsy.


congenital diaphragmatic hernia

description: A posterolateral defect of the diaphragm that allows passage of abdominal viscera into the thorax, leading to respiratory insufficiency and persistent pulmonary hypertension with high mortality.


sapropterin

A tetrahydropterin that is 2-amino-5,6,7,8-tetrahydropteridin-4(3H)-one in which a hydrogen at position 6 is substituted by a 1,2-dihydroxypropyl group (6R,1'R,2'S-enantiomer).


name: S47A2_HUMAN Multidrug and toxin extrusion protein 2 (sprot)

description: A multidrug and toxin extrusion protein 2 that is encoded in the genome of human.


name: PON2_HUMAN Serum paraoxonase/arylesterase 2 (sprot)

description: A serum paraoxonase/arylesterase 2 that is encoded in the genome of human.


name: GYS2_HUMAN Glycogen [starch] synthase, liver (sprot)

description: A glycogen [starch] synthase, liver that is encoded in the genome of human.


ovarian carcinosarcoma

description: A highly aggressive malignant neoplasm arising from the ovary. Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements.


name: LAPM5_HUMAN Lysosomal-associated transmembrane protein 5 (sprot)

description: A lysosomal-associated transmembrane protein 5 that is encoded in the genome of human.


name: TR10C_HUMAN Tumor necrosis factor receptor superfamily member 10C (sprot)

description: A tumor necrosis factor receptor superfamily member 10C that is encoded in the genome of human.


TLE5_HUMAN TLE family member 5 (sprot)

A TLE family member 5 that is encoded in the genome of human.


name: Ewing sarcoma/peripheral primitive neuroectodermal tumor

description: A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. These tumors may occur in the soft tissues or the bones. Pain and the presence of a mass are the most common clinical symptoms.


name: EXOS2_HUMAN Exosome complex component RRP4 (sprot)

description: An exosome complex component RRP4 that is encoded in the genome of human.


name: SUV3_HUMAN ATP-dependent RNA helicase SUPV3L1, mitochondrial (sprot)

description: An ATP-dependent RNA helicase SUPV3L1, mitochondrial that is encoded in the genome of human.


pralatrexate

A pteridine that is the N-4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl derivative of L-glutamic acid. Used for treatment of Peripheral T-Cell Lymphoma, an aggressive form of non-Hodgkins lymphoma.


name: ANGL1_HUMAN Angiopoietin-related protein 1 (sprot)

description: An angiopoietin-related protein 1 that is encoded in the genome of human.


name: PP2AB_HUMAN Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (sprot)

description: A serine/threonine-protein phosphatase 2A catalytic subunit beta isoform that is encoded in the genome of human.


name: STAG1_HUMAN Cohesin subunit SA-1 (sprot)

description: A cohesin subunit SA-1 that is encoded in the genome of human.


name: SCC4_HUMAN MAU2 chromatid cohesion factor homolog (sprot)

description: A MAU2 chromatid cohesion factor homolog that is encoded in the genome of human.


name: FUMH_HUMAN Fumarate hydratase, mitochondrial (sprot)

description: A fumarate hydratase, mitochondrial that is encoded in the genome of human.


sulfachlorpyridazine

A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.


bongkrek acid

A tricarboxylic acid that is docosa-2,4,8,10,14,18,20-heptaenedioic acid substituted at positions 2 ,5 and 17 by methyl groups, at positions 6 by a methoxy group and at position 20 by a carboxymethyl group. It is produced by the bacterium Burkholderia gladioli and implicated in outbreaks of food-borne illness involving coconut and corn-based products in Indonesia and China.


name: RIMS2_HUMAN Regulating synaptic membrane exocytosis protein 2 (sprot)

description: A regulating synaptic membrane exocytosis protein 2 that is encoded in the genome of human.


name: EPHA2_HUMAN Ephrin type-A receptor 2 (sprot)

description: An ephrin type-A receptor 2 that is encoded in the genome of human.


name: ATS4_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 4 (sprot)

description: An a disintegrin and metalloproteinase with thrombospondin motifs 4 that is encoded in the genome of human.


name: FGFR4_HUMAN Fibroblast growth factor receptor 4 (sprot)

description: A fibroblast growth factor receptor 4 that is encoded in the genome of human.


name: TNR18_HUMAN Tumor necrosis factor receptor superfamily member 18 (sprot)

description: A tumor necrosis factor receptor superfamily member 18 that is encoded in the genome of human.


P2RX5_HUMAN P2X purinoceptor 5 (sprot)

A P2X purinoceptor 5 that is encoded in the genome of human.


REL3_HUMAN Relaxin-3 (sprot)

A relaxin-3 that is encoded in the genome of human.


name: TCAM1_HUMAN TIR domain-containing adapter molecule 1 (sprot)

description: A TIR domain-containing adapter molecule 1 that is encoded in the genome of human.


name: GPA33_HUMAN Cell surface A33 antigen (sprot)

description: A cell surface A33 antigen that is encoded in the genome of human.


AQP1_HUMAN Aquaporin-1 (sprot)

An aquaporin-1 that is encoded in the genome of human.


therapy-related myeloid neoplasm

description: Acute myeloid leukemias, myelodysplastic syndromes, and myelodysplastic/myeloproliferative neoplasms arising as a result of the mutagenic effect of chemotherapy agents and/or radiation that are used for the treatment of neoplastic or non-neoplastic disorders.


Menometrorrhagia

description: Prolonged/excessive menses and bleeding at irregular intervals.


Rp-cAMPS

A nucleoside 3',5'-cyclic phosphorothioate having adenine as the nucleobase (the Rp-stereoisomer).


name: I17RA_HUMAN Interleukin-17 receptor A (sprot)

description: An interleukin-17 receptor A that is encoded in the genome of human.


SPB3_HUMAN Serpin B3 (sprot)

A serpin B3 that is encoded in the genome of human.


S10A7_HUMAN Protein S100-A7 (sprot)

A protein S100-A7 that is encoded in the genome of human.


name: TOM22_HUMAN Mitochondrial import receptor subunit TOM22 homolog (sprot)

description: A mitochondrial import receptor subunit TOM22 that is encoded in the genome of human.


name: YTHD2_HUMAN YTH domain-containing family protein 2 (sprot)

description: A YTH domain-containing family protein 2 that is encoded in the genome of human.


ETHYLENEDIAMINE

An alkane-alpha,omega-diamine in which the alkane is ethane.


D-cysteine

An optically active form of cysteine having D-configuration.


monosodium glutamate

An organic sodium salt that is the monosodium salt of glutamic acid.


KLKB1_HUMAN Plasma kallikrein (sprot)

A plasma kallikrein that is encoded in the genome of human.


PMEPA_HUMAN Protein TMEPAI (sprot)

A protein TMEPAI that is encoded in the genome of human.


name: MO4L2_HUMAN Mortality factor 4-like protein 2 (sprot)

description: A mortality factor 4-like protein 2 that is encoded in the genome of human.


SODIUM CITRATE

The trisodium salt of citric acid.


GINSENOSIDE RG1

A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 position.


name: KCNU1_HUMAN Potassium channel subfamily U member 1 (sprot)

description: A potassium channel subfamily U member 1 that is encoded in the genome of human.


chronic graft versus host disease

description: Chronic graft versus host disease (GVHD) is a complication that can occur after a stem cell or bone marrow transplant in which the newly transplanted donor cells attack the transplant recipient's body. Symptoms may include skin rash, mouth sores, dry eyes, liver inflammation, development of scar tissue in the skin and joints, and damage to the lungs. The exact cause of chronic GVHD is unknown.It likely results from a complex immune-mediated interaction between the donor and recipient cells.Chronic GVHD is treated with prednisone or other similar anti-inflammatory or immunosuppressive medications.


name: SLAF5_HUMAN SLAM family member 5 (sprot)

description: A SLAM family member 5 that is encoded in the genome of human.


name: DDX10_HUMAN Probable ATP-dependent RNA helicase DDX10 (sprot)

description: A probable ATP-dependent RNA helicase DDX10 that is encoded in the genome of human.


name: PP1R8_HUMAN Nuclear inhibitor of protein phosphatase 1 (sprot)

description: A nuclear inhibitor of protein phosphatase 1 that is encoded in the genome of human.


PELARGONIDIN CHLORIDE

An anthocyanidin chloride that has pelargonidin as the cationic counterpart.


autoimmune uveitis

description: An autoimmune form of uveitis (disease).


name: LY6E_HUMAN Lymphocyte antigen 6E (sprot)

description: A lymphocyte antigen 6E that is encoded in the genome of human.


tenofovir alafenamide

An L-alanine derivative that is isopropyl L-alaninate in which one of the amino hydrogens is replaced by an (S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl group. A prodrug for tenofovir, it is used (as the fumarate salt) in combination therapy for the treatment of HIV-1 infection.


name: FKBP2_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP2 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP2 that is encoded in the genome of human.


name: SC24C_HUMAN Protein transport protein Sec24C (sprot)

description: A protein transport protein Sec24C that is encoded in the genome of human.


name: RET3_HUMAN Retinol-binding protein 3 (sprot)

description: A retinol-binding protein 3 that is encoded in the genome of human.


Motor axonal neuropathy

description: Progressive impairment of function of motor axons with muscle weakness, atrophy, and cramps. The deficits are length-dependent, meaning that muscles innervated by the longest nerves are affected first, so that for instance the arms are affected at a later age than the onset of deficits involving the lower leg.


name: RBMS1_HUMAN RNA-binding motif, single-stranded-interacting protein 1 (sprot)

description: An RNA-binding motif, single-stranded-interacting protein 1 that is encoded in the genome of human.


name: MYSM1_HUMAN Deubiquitinase MYSM1 (sprot)

description: A deubiquitinase MYSM1 that is encoded in the genome of human.


name: DDX3X_HUMAN ATP-dependent RNA helicase DDX3X (sprot)

description: An ATP-dependent RNA helicase DDX3X that is encoded in the genome of human.


name: PTOV1_HUMAN Prostate tumor-overexpressed gene 1 protein (sprot)

description: A prostate tumor-overexpressed gene 1 protein that is encoded in the genome of human.


ixabepilone

A macrocycle that is a lactam analogue of epothilone B. Binds directly to beta-tubulin subunits on microtubules, leading to suppression of microtubule dynamics.


lamellar ichthyosis

description: A keratinization disorder characterized by the presence of large scales all over the body without significant erythroderma.


A2AP_HUMAN Alpha-2-antiplasmin (sprot)

An alpha-2-antiplasmin that is encoded in the genome of human.


LFG4_HUMAN Protein lifeguard 4 (sprot)

A protein lifeguard 4 that is encoded in the genome of human.


chronic leukemia

description: A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia.


name: HXA10_HUMAN Homeobox protein Hox-A10 (sprot)

description: A homeobox protein Hox-A10 that is encoded in the genome of human.


S26A5_HUMAN Prestin (sprot)

A prestin that is encoded in the genome of human.


alcoholic fatty liver disease

description: Lipid infiltration of the hepatic parenchymal cells that is due to alcohol abuse. The fatty changes in the alcoholic fatty liver may be reversible, depending on the amounts of triglycerides accumulated.


calcium carbonate

A calcium salt with formula CCaO3.


name: ZSCA4_HUMAN Zinc finger and SCAN domain-containing protein 4 (sprot)

description: A zinc finger and SCAN domain-containing protein 4 that is encoded in the genome of human.


name: AGRB1_HUMAN Adhesion G protein-coupled receptor B1 (sprot)

description: An adhesion G protein-coupled receptor B1 that is encoded in the genome of human.


name: LIGO1_HUMAN Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (sprot)

description: A leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 that is encoded in the genome of human.


high grade B-cell lymphoma

description: A term that refers to high grade B-cell lymphoma, not otherwise specified or high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements.


name: KI3S1_HUMAN Killer cell immunoglobulin-like receptor 3DS1 (sprot)

description: A killer cell immunoglobulin-like receptor 3DS1 that is encoded in the genome of human.


name: KI3L1_HUMAN Killer cell immunoglobulin-like receptor 3DL1 (sprot)

description: A killer cell immunoglobulin-like receptor 3DL1 that is encoded in the genome of human.


acenaphthylene

A ortho- and peri-fused tricyclic hydrocarbon that occurs in coal tar.


glycolipid

Any member of class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar part acylated by one or more fatty acids and the glycerol part may be absent.


Niemann-Pick disease type C

description: NPC is a complex lipid storage disease mainly characterized by the accumulation of unesterified cholesterol in the late endosomal/lysosomal compartment.


name: STK38_HUMAN Serine/threonine-protein kinase 38 (sprot)

description: A serine/threonine-protein kinase 38 that is encoded in the genome of human.


clobazam

7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.


Persistent fever

description: Fever that persists longer than expected for an acute infectious disease. No precise threshold exists, and the clinical interpretation of fever is context-dependent, but as a rule of thumb, this term refers to fever that persists longer than 2-3 weeks.


primary hypophysitis

description: Immune-mediated inflammation of the pituitary gland often associated with other autoimmune diseases (e.g., hashimoto disease; graves disease; and addison disease).


name: NACC1_HUMAN Nucleus accumbens-associated protein 1 (sprot)

description: A nucleus accumbens-associated protein 1 that is encoded in the genome of human.


name: PMEL_HUMAN Melanocyte protein PMEL (sprot)

description: A melanocyte protein Pmel 17 that is encoded in the genome of human.


bismuth subsalicylate

A bismuth salt of salicylic acid.


name: LOX12_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX12 (sprot)

description: A polyunsaturated fatty acid lipoxygenase ALOX12 that is encoded in the genome of human.


name: NB5R3_HUMAN NADH-cytochrome b5 reductase 3 (sprot)

description: An NADH-cytochrome b5 reductase 3 that is encoded in the genome of human.


name: SOS2_HUMAN Son of sevenless homolog 2 (sprot)

description: A son of sevenless homolog 2 that is encoded in the genome of human.


name: RS3A_HUMAN Small ribosomal subunit protein eS1 (sprot)

description: A small ribosomal subunit protein eS1 that is encoded in the genome of human.


name: CD2B2_HUMAN CD2 antigen cytoplasmic tail-binding protein 2 (sprot)

description: A CD2 cytoplasmic tail-binding protein 2 that is encoded in the genome of human.


ROCAGLAMIDE

An organic heterotricyclic compound that is 2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan substituted by hydroxy groups at positions 1 and 8b, methoxy groups at positions 6 and 8, a 4-methoxyphenyl group at position 3a, a phenyl group at position 3 and a N,N-dimethylcarbamoyl group at position 1. Isolated from Aglaia odorata and Aglaia duperreana, it exhibits antineoplastic activity.


neoplasm of cerebral hemisphere

description: A neoplasm involving a cerebral hemisphere.


name: FXL14_HUMAN F-box/LRR-repeat protein 14 (sprot)

description: An F-box/LRR-repeat protein 14 that is encoded in the genome of human.


name: TSPY8_HUMAN Testis-specific Y-encoded protein 8 (sprot)

description: A testis-specific Y-encoded protein 8 that is encoded in the genome of human.


name: TSYL1_HUMAN Testis-specific Y-encoded-like protein 1 (sprot)

description: A testis-specific Y-encoded-like protein 1 that is encoded in the genome of human.


Wallerian degeneration

description: A condition caused by degeneration, atrophy, and destruction of the distal part of a nerve fiber's axon and myelin, when continuity with the neural cell nucleus has been severed due to injury. Signs and symptoms include muscle weakness, altered sensation, and limb numbness.


name: 5NT3A_HUMAN Cytosolic 5'-nucleotidase 3A (sprot)

description: A cytosolic 5'-nucleotidase 3A that is encoded in the genome of human.


familial tumoral calcinosis

description: Tumoral calcinosis is a phosphocalcic metabolism anomaly, particularly among younger age groups and characterized by the presence of calcified masses in the juxta-articular regions (hip, elbow, ankle and scapula) without joint involvement. Histologically, lesions dysplay collagen necrobiosis, followed by cyst formation and a foreign-body response with calcification Two forms of tumoral calcinosis have been described: normocalcemic tumoral calcinosis and familial tumoral calcinosis.


name: MAFK_HUMAN Transcription factor MafK (sprot)

description: A transcription factor MafK that is encoded in the genome of human.


systemic mastocytosis

description: Systemic mastocytosis (SM) comprises a heterogeneous group of rare acquired and chronic hematological malignancies that are related to an abnormal proliferation of mast cells in tissue, including bone marrow, with or without skin involvement.


squalene

A triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration.


name: LDLR_HUMAN Low-density lipoprotein receptor (sprot)

description: A low-density lipoprotein receptor that is encoded in the genome of human.


name: CSRP1_HUMAN Cysteine and glycine-rich protein 1 (sprot)

description: A cysteine and glycine-rich protein 1 that is encoded in the genome of human.


name: HG2A_HUMAN HLA class II histocompatibility antigen gamma chain (sprot)

description: An MHC class II histocompatibility antigen gamma chain that is encoded in the genome of human.


potassium aluminium sulfate

A metal sulfate composed of potassium, aluminium and sulfate ions in the ration 1:1:2.


dextran sulfate

A polymer composed of repeating (1->6)-alpha-linked anhydroglucose sulfate units.


name: IRX1_HUMAN Iroquois-class homeodomain protein IRX-1 (sprot)

description: An iroquois-class homeodomain protein IRX-1 that is encoded in the genome of human.


carcinoma of duodenum

description: A carcinoma that involves the duodenum.


name: S36A2_HUMAN Proton-coupled amino acid transporter 2 (sprot)

description: A proton-coupled amino acid transporter 2 that is encoded in the genome of human.


name: PBX3_HUMAN Pre-B-cell leukemia transcription factor 3 (sprot)

description: A pre-B-cell leukemia transcription factor 3 that is encoded in the genome of human.


stomatitis

description: Inflammation of the oral mucosa due to local or systemic factors.


name: DUS16_HUMAN Dual specificity protein phosphatase 16 (sprot)

description: A dual specificity protein phosphatase 16 that is encoded in the genome of human.


name: PRS10_HUMAN 26S proteasome regulatory subunit 10B (sprot)

description: A 26S proteasome regulatory subunit 10B that is encoded in the genome of human.


name: PSD12_HUMAN 26S proteasome non-ATPase regulatory subunit 12 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 12 that is encoded in the genome of human.


DOK4_HUMAN Docking protein 4 (sprot)

A docking protein 4 that is encoded in the genome of human.


name: PRAF3_HUMAN PRA1 family protein 3 (sprot)

description: A PRA1 family protein 3 that is encoded in the genome of human.


terbinafine

A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections.


name: S14L3_HUMAN SEC14-like protein 3 (sprot)

description: A SEC14-like protein 3 that is encoded in the genome of human.


name: YBOX3_HUMAN Y-box-binding protein 3 (sprot)

description: A Y-box-binding protein 3 that is encoded in the genome of human.


hereditary spherocytosis

description: Hereditary spherocytosis is a congenital hemolytic anemia with a wide clinical spectrum (from symptom-free carriers to severe hemolysis) characterized by anemia, variable jaundice, splenomegaly and cholelithiasis.


Tachycardia

description: A rapid heartrate that exceeds the range of the normal resting heartrate for age.


name: SPIC_HUMAN Transcription factor Spi-C (sprot)

description: A transcription factor Spi-C that is encoded in the genome of human.


name: DUS4_HUMAN Dual specificity protein phosphatase 4 (sprot)

description: A dual specificity protein phosphatase 4 that is encoded in the genome of human.


SPR1B_HUMAN Cornifin-B (sprot)

A cornifin-B that is encoded in the genome of human.


name: CBR3_HUMAN Carbonyl reductase [NADPH] 3 (sprot)

description: A carbonyl reductase [NADPH] 3 that is encoded in the genome of human.


Paraplegia/paraparesis

description: Weakness of both lower extremities with sparing of the upper extremities. Paraplegia refers to a severe or complete loss of strength, whereas paraparesis refers to a relatively mild loss of strength.


name: SERP1_HUMAN Stress-associated endoplasmic reticulum protein 1 (sprot)

description: A stress-associated endoplasmic reticulum protein 1 that is encoded in the genome of human.


vitamin deficiency disorder

description: A disorder that is caused by the deficiency of a vitamin. The deficiency may result from either suboptimal vitamin intake or conditions that prevent the vitamin's use or absorption in the body. Representative examples include beriberi caused by thiamine deficiency, scurvy caused by vitamin C deficiency, and rickets caused by vitamin D deficiency.


fruquintinib

A member of the class of quinazolines that is quinazoline substituted by [2-methyl-3-(methylcarbamoyl)-1-benzofuran-6-yl]oxy, methoxy, and methoxy groups at positions 4, 6, and 7, respectively. It is a highly potent and selective inhibitor of VEGFR 1, 2 and 3 (IC50 = 33, 0.35, and 35 nM) used for the treatment of metastatic colorectal cancer.


name: DRD3_HUMAN D(3) dopamine receptor (sprot)

description: A D(3) dopamine receptor that is encoded in the genome of human.


SIDEROXYLIN

A  monomethoxyflavone that is flavone substituted by a methoxy group at position 7, hydroxy groups at positions 5 and 4' and methyl groups at positions 6 and 8. It has been isolated from Hydrastis canadensis and Eucalyptus species.


multiple system atrophy

description: Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic failure (cardiovascular and/or urinary), parkinsonism, cerebellar impairment and corticospinal signs with a median survival of 6-9 years.


name: PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (sprot)

description: A serine/threonine-protein kinase PAK 4 that is encoded in the genome of human.


name: CSPG4_HUMAN Chondroitin sulfate proteoglycan 4 (sprot)

description: A chondroitin sulfate proteoglycan 4 that is encoded in the genome of human.


GINSENOSIDE RB1

A ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group.


frontotemporal dementia

description: Frontotemporal dementia (FTD) comprises a group of neurodegenerative disorders, characterized by progressive changes in behavior, executive dysfunction and language impairment, as a result of degeneration of the medial prefrontal and frontoinsular cortices. Four clinical subtypes have been identified: semantic dementia, progressive non-fluent aphasia, behavioral variant FTD and right temporal lobar atrophy.


metabolic acidosis

description: Increased acidity in the blood secondary to acid base imbalance. Causes include diabetes, kidney failure and shock.


ETHANE

An alkane comprising of two carbon atoms.


name: Chronic active Epstein-Barr virus infection

description: Chronic active Epstein-Barr virus (EBV) infection is an uncommon outcome of EBV infection and may present as a waxing and waning or fulminant syndrome. Unlike acute infectious mononucleosis, wherein EBV establishes lifelong infection and survives by maintaining a delicate balance with the host as a latent infection, in chronic active EBV infection the host-virus balance is disturbed.


FLNB_HUMAN Filamin-B (sprot)

A filamin-B that is encoded in the genome of human.


A organic heterooctacyclic compound that is a potent inhibitor of protein kinase C and is isolated from Nocardiopsis sp K-252a


name: MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 (sprot)

description: A dual specificity mitogen-activated protein kinase kinase 7 that is encoded in the genome of human.


amorolfine

A member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections.


tinea corporis

description: A dermatophyte disease of the glabrous skin, excluding the scalp, beard, face, hands, feet, and groin.


name: GP1BA_HUMAN Platelet glycoprotein Ib alpha chain (sprot)

description: A platelet glycoprotein Ib alpha chain that is encoded in the genome of human.


generalized dystonia

description: A type of dystonia that affects all or most of the body.


S10AC_HUMAN Protein S100-A12 (sprot)

A protein S100-A12 that is encoded in the genome of human.


name: PEX5_HUMAN Peroxisomal targeting signal 1 receptor (sprot)

description: A peroxisomal targeting signal 1 receptor that is encoded in the genome of human.


name: PLCC_HUMAN 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (sprot)

description: A 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma that is encoded in the genome of human.


name: BIRC6_HUMAN Baculoviral IAP repeat-containing protein 6 (sprot)

description: A baculoviral IAP repeat-containing protein 6 that is encoded in the genome of human.


phosphatidylcholine (17:0/18:2)

A phosphatidylcholine 35:2 in which the fatty acyl groups at positions 1 and 2 are specified as C17:0 and C18:2 respectively.


name: ATF1_HUMAN Cyclic AMP-dependent transcription factor ATF-1 (sprot)

description: A cyclic AMP-dependent transcription factor ATF-1 that is encoded in the genome of human.


name: ASB9_HUMAN Ankyrin repeat and SOCS box protein 9 (sprot)

description: An ankyrin repeat and SOCS box protein 9 that is encoded in the genome of human.


MT2_HUMAN Metallothionein-2 (sprot)

A metallothionein-2 that is encoded in the genome of human.


name: MAGD1_HUMAN Melanoma-associated antigen D1 (sprot)

description: A melanoma-associated antigen D1 that is encoded in the genome of human.


name: LOXE3_HUMAN Hydroperoxide isomerase ALOXE3 (sprot)

description: A hydroperoxide isomerase ALOXE3 that is encoded in the genome of human.


cyclic vomiting syndrome

description: A rare abnormality of the neuroendocrine system that is characterized by episodic nausea and vomiting.


NEUG_HUMAN Neurogranin (sprot)

A neurogranin that is encoded in the genome of human.


name: RIR2_HUMAN Ribonucleoside-diphosphate reductase subunit M2 (sprot)

description: A ribonucleoside-diphosphate reductase subunit M2 that is encoded in the genome of human.


FLNC_HUMAN Filamin-C (sprot)

A filamin-C that is encoded in the genome of human.


acute closed-angle glaucoma

description: Acute form of angle-closure glaucoma.


A pyrrolotriazine that is pyrrolo[2,1-f][1,2,4]triazine which is substituted at position 2 by the pyrrolidine nitrogen of (2S)-N-(6-fluoropyridin-3-yl)-2-methylprolinamide, and at position 4 by a (5-cyclopropyl-1H-pyrazol-3-yl)amino group. It is a potent, reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases.


thalassemia

description: An inherited blood disorder characterized by a decreased synthesis of one of the polypeptide chains that form hemoglobin. Anemia results from this abnormal hemoglobin formation.


name: S38A2_HUMAN Sodium-coupled neutral amino acid symporter 2 (sprot)

description: A sodium-coupled neutral amino acid symporter 2 that is encoded in the genome of human.


pracinostat

A hydroxamic acid that is N-hydroxyacrylamide which is substituted at position 3 by a 2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl group (the E isomer). An orally available pan-histone deacetylase inhibitor with demonstrated activity in the treatment of advanced solid tumours.


name: FMO5_HUMAN Flavin-containing monooxygenase 5 (sprot)

description: A flavin-containing monooxygenase 5 that is encoded in the genome of human.


name: DPF3_HUMAN Zinc finger protein DPF3 (sprot)

description: A zinc finger protein DPF3 that is encoded in the genome of human.


name: ACOX2_HUMAN Peroxisomal acyl-coenzyme A oxidase 2 (sprot)

description: A peroxisomal acyl-coenzyme A oxidase 2 that is encoded in the genome of human.


name: BC11B_HUMAN B-cell lymphoma/leukemia 11B (sprot)

description: A B-cell lymphoma/leukemia 11B that is encoded in the genome of human.


beriberi

description: Beriberi is a condition that occurs in people who are deficient in thiamine (vitamin B1). There are two major types of beriberi: wet beriberi which affects the cardiovascular system and dry beriberi which affects the nervous system. People with wet beriberi may experience increased heart rate, shortness of breath, and swelling of the lower legs. Signs and symptoms of dry beriberi include difficulty walking; loss of feeling in the hands and/or feet; paralysis of the lower legs; mental confusion; speech difficulty; pain; and/or vomiting. Beriberi is rare in the United States since many foods are now vitamin enriched; however, alcohol abuse, dialysis and taking high doses of diuretics increases the risk of developing the condition. In most cases,beriberi occurs sporadically in people with no family history of the condition. A rare condition known as genetic beriberi is inherited (passed down through families) and is associated with an inability to absorb thiamine from foods. Treatment generally includes thiamine supplementation, given by injection or taken by mouth.


name: SRS10_HUMAN Serine/arginine-rich splicing factor 10 (sprot)

description: A serine/arginine-rich splicing factor 10 that is encoded in the genome of human.


name: PRR3_HUMAN Proline-rich protein 3 (sprot)

description: A proline-rich protein 3 that is encoded in the genome of human.


LBN_HUMAN Limbin (sprot)

A limbin that is encoded in the genome of human.


name: PRND_HUMAN Prion-like protein doppel (sprot)

description: A prion-like protein doppel that is encoded in the genome of human.


conversion disorder

description: Conversion disorder is a disorder in which a person experiences blindness, paralysis, or other symptoms affecting the nervous system that cannot be explained solely by a physical illness or injury. Symptoms usually begin suddenly after a period of emotional or physical distress or psychological conflict. Conversion disorder is thought to be caused by the bodys reaction to a stressful physical or emotional event. Some research has identified potential neurological changes that may be related to symptoms of the disorder. Diagnosis of conversion disorder is based on identifying particular signs that are common among people with the disorder, as well as performing tests to rule out other causes of the symptoms. Treatment may include psychotherapy, hypnosis, and stress management training to help reduce symptoms. Treatment of any underlying psychological disorder is also recommended. The affected body part may require physical or occupational therapy until symptoms resolve.


adefovir dipivoxil

An organic phosphonate that is the dipivoxil ester of adefovir. A prodrug for adefovir, an HIV-1 reverse transcriptase inhibitor, adefovir pivoxil is used to treat chronic hepatitis B viral infection.


anaplastic astrocytoma

description: Anaplastic astrocytoma is a rare, high-grade, malignant glial tumor, histologically characterized by abundance of pleomorphic astrocytes and multiple mitotic figures, often associated with diffuse infiltration of the surrounding tissue, considerable edema and mass effect and involvement of the contralateral brain. Depending on the primary localization of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), seizures, progressive neurological deficits, and/or behavioral changes. The tumor is most commonly localized in the frontal and temporal lobes, brain stem and spinal cord.


name: UGGG1_HUMAN UDP-glucose:glycoprotein glucosyltransferase 1 (sprot)

description: A UDP-glucose:glycoprotein glucosyltransferase 1 that is encoded in the genome of human.


CLN8_HUMAN Protein CLN8 (sprot)

A protein CLN8 that is encoded in the genome of human.


name: TXN4B_HUMAN Thioredoxin-like protein 4B (sprot)

description: A thioredoxin-like protein 4B that is encoded in the genome of human.


vesicular stomatitis

description: A viral disease caused by at least two distinct species (serotypes) in the vesiculovirus genus: vesicular stomatitis indiana virus and vesicular stomatitis new jersey virus. It is characterized by vesicular eruptions on the oral mucosa in cattle, horses, pigs, and other animals. In humans, vesicular stomatitis causes an acute influenza-like illness.


FOSFONET

A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.


cerebritis

description: Inflammation of the cerebrum.


ergometrine

A monocarboxylic acid amide that  is lysergamide in which one of the hydrogens attached to the amide nitrogen is substituted by a 1-hydroxypropan-2-yl group (S-configuration). An ergot alkaloid that has a particularly powerful action on the uterus, its maleate (and formerly tartrate) salt is used in the active management of the third stage of labour, and to prevent or treat postpartum of postabortal haemorrhage caused by uterine atony: by maintaining uterine contraction and tone, blood vessels in the uterine wall are compressed and blood flow reduced.


sick sinus syndrome

description: A constellation of signs and symptoms which may include syncope, fatigue, dizziness, and alternating periods of bradycardia and atrial tachycardia, which is caused by sinoatrial node dysfunction.


SODIUM FORMATE

An organic sodium salt which is the monosodium salt of formic acid.


name: NUBPL_HUMAN Iron-sulfur cluster transfer protein NUBPL (sprot)

description: A nucleotide-binding protein-like that is encoded in the genome of human.