name: Stage I Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: pT1-4, N0, M0, SX. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage IIC Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Any pT, N3, M0, S0, S1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Testicular Yolk Sac Tumor

description: A yolk sac tumor that arises from the testis during childhood.


HOMOSERINE LACTONE

The L-enantiomer of homoserine lactone.


The (R)-enantiomer of 2-benzylsuccinyl-CoA.


omega-carboxyacyl-CoA

An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of any alpha,omega-dicarboxylic acid.


A 3-hydroxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 3-hydroxypimelic acid.


An omega-carboxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 2-benzylsuccinic acid.


pimeloyl-CoA

An omega carboxyacyl-CoA that is the S-pimeloyl derivative of coenzyme A.


oxalyl-CoA

An omega-carboxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of oxalic acid.


mesaconyl-CoA

An omega-carboxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the 1-carboxy group of mesaconic acid.


(R)-ethylmalonyl-CoA

An omega-carboxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of (R)-ethylmalonic acid.


An omega-carboxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the least hindered carboxy group of mesaconic acid.


(S)-ethylmalonyl-CoA

An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of (2S)-ethylmalonic acid.


The S-3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl derivative of CoA.


decanedioyl-CoA

An alpha,omega dicarboxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of decanedioic acid.


adipoyl-CoA

An alpha,omega dicarboxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of adipic acid.


A 3-hydroxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the 3-carboxy group of 3-carboxy-3-hydroxypropanoic acid.


octanedioyl-CoA

An alpha,omega dicarboxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of octanedioic acid.


A 3-hydroxy-3-methylglutaryl-CoA where the 3-hydroxy-3-methylglutaryl component has (S)-configuration.


glutaryl-CoAs

Any  omega-carboxyacyl-CoA in which the acyl group specified is glutaryl or its substituted derivative.


An alpha,omega dicarboxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of 3-hydroxy-3-methylglutaric acid.


dodecanedioyl-CoA

An alpha,omega dicarboxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of dodecanedioic acid.


Intermediate Grade Osteosarcoma

description: An osteosarcoma with intermediate-grade morphological features. A representative example is periosteal osteosarcoma.


name: Peripheral Nervous System Infectious Disorder

description: An infectious process affecting the peripheral nerves.


A glycosylmannose consisting of two D-mannopyranose residues joined via an alpha-(1->3)-linkage.


name: (6S)-6-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide 2'-phosphate


name: tetrahydronicotinamide adenine dinucleotide phosphate

description: A nicotinamide dinucleotide having any tetrahydronicotinamide and adenosine as the nucleobases as well as an additional phosphate group.


B-Cell Malignant Neoplasm

description: A clonal lymphoproliferative disorder composed of neoplastic B-cells. It includes B-cell non-Hodgkin lymphomas, B-cell leukemias, and plasma cell myeloma.


Chronic lymphocytic leukemia stage 1

description: Risk: Intermediate; Findings: Lymphocytosis and adenopathy; Survival (months): 95. (from AJCC 8th Ed.)


name: Multiple Myeloma with MAF Family Translocation

description: Multiple myeloma characterized by the presence of a translocation involving a MAF family gene.


DS Stage IA Multiple Myeloma

description: Durie/Salmon stage I multiple myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


name: B Acute Lymphoblastic Leukemia with t(4;11)(q21;23.3); KMT2A-AFF1

description: A B-cell acute lymphoblastic leukemia associated with t(4;11)(q21;23.3). This translocation leads to the generation of the fusion gene KMT2A-AFF1.


name: Childhood B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

description: A B acute lymphoblastic leukemia that occurs during childhood. It is characterized by the presence of lymphoblasts that carry a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. It results in the production of the p190 kd or p210 kd fusion protein. It has an unfavorable clinical outcome.


name: Hypodiploid B Acute Lymphoblastic Leukemia

description: A B-cell acute leukemia characterized by the presence of lymphoblasts which contain less than 46 chromosomes. It occurs in both children and adults. It has an unfavorable clinical outcome.


Recurrent Chronic Lymphoid Leukemia

description: The reemergence of chronic lymphocytic leukemia after a period of remission.


name: Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

description: Chronic lymphocytic leukemia/small lymphocytic lymphoma that does not respond to treatment.


name: Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

description: The reemergence of chronic lymphocytic leukemia/small lymphocytic lymphoma after a period of remission.


name: Refractory B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

description: B-acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 that is resistant to treatment.


Leptomeningeal myelomatosis

description: A central nervous system multiple myeloma involving the leptomeninges.


name: B Acute Lymphoblastic Leukemia with Recurrent Genetic Abnormalities

description: B-acute lymphoblastic leukemias characterized by the presence of recurring cytogenetic and/or molecular abnormalities.


name: Refractory B Acute Lymphoblastic Leukemia

description: B-acute lymphoblastic leukemia that does not respond to treatment.


Plasma cell myeloma recurrent

description: The reemergence of multiple myeloma after a period of remission.


DS Stage IIIB Multiple Myeloma

description: Durie/Salmon stage III multiple myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


name: Recurrent B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

description: The reemergence of  B-acute lymphoblastic leukemia, BCR-ABL1-like after a period of remission.


name: B Acute Lymphoblastic Leukemia with ETV6-RUNX1-Like Features

description: B acute lymphoblastic leukemia characterized by a gene-expression profile similar to that of ETV6-RUNX1-positive B acute lymphoblastic leukemia, absence of the pathognomonic ETV6-RUNX1 rearrangement, and rearrangements or deletions of ETV6 and IKZF1 genes.


name: Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder

description: A clonal B-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed B-lymphocytes or plasma cells. The clonal cellular infiltrates fulfill the criteria for a diffuse large B-cell lymphoma, Burkitt lymphoma, or a plasma cell neoplasm.


name: Recurrent B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

description: The reemergence of B acute lymphoblastic leukemia, Philadelphia chromosome negative, after a period of remission.


name: Multiple Myeloma, Not Otherwise Specified

description: Multiple myelomas characterized by the absence of recurrent genetic abnormalities.


name: B Acute Lymphoblastic Leukemia, Not Otherwise Specified

description: B-acute lymphoblastic leukemias characterized by the absence of recurrent genetic abnormalities.


name: Extramedullary Disease in Multiple Myeloma Involving the Central Nervous System

description: Multiple myeloma involving the central nervous system. It manifests with single or multiple intraparenchymal lesions and/or leptomeningeal involvement. Patients present with diffuse cerebral dysfunction and nerve paralysis. The prognosis is poor.


Stage A Chronic Lymphocytic Leukemia

description: Findings: Lymphocytosis only; Survival (months): more than 120. (from AJCC 8th Ed.)


name: Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene

description: Chronic lymphocytic leukemia characterized by the absence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a significantly worse prognosis as compared to those with mutated immunoglobulin heavy chain gene variable region rearrangements.


name: B Acute Lymphoblastic Leukemia with Mutated ZEB2 (p.H1038R)

description: B-acute lymphoblastic leukemia associated with mutations in the ZEB2 gene that encode a histidine to arginine amino acid substitution at codon 1038. This variation appears to phenocopy the IGH-CEBPE gene fusion. This is a provisional entity.


name: Refractory B-Cell Prolymphocytic Leukemia

description: B-cell prolymphocytic leukemia that is resistant to treatment.


name: Chronic Lymphocytic Leukemia- Binet Staging System

description: A term that refers to the staging of chronic lymphocytic leukemia according to Binet staging system. This system is in wide use outside the United States.


Chronic lymphocytic leukemia stage 4

description: Risk: High; Findings: Lymphocytosis and platelets less than 100,000/microliter; Survival (months): 30. (from AJCC 8th Ed.)


name: Cutaneous B Lymphoblastic Leukemia/Lymphoma

description: B-lymphoblastic leukemia/lymphoma that affects the skin.


Recurrent Extraosseous Plasmacytoma

description: The reemergence of extraosseous plasmacytoma after a period of remission.


Recurrent Solitary Plasmacytoma

description: The reemergence of solitary plasmacytoma after a period of remission.


Stage B Chronic Lymphocytic Leukemia

description: Findings: Lymphocytosis and adenopathy; Survival (months): 95. (from AJCC 8th Ed.)


name: Multiple Myeloma Post-Transplant Lymphoproliferative Disorder

description: A lymphoproliferative disorder that develops following an organ transplantation and exhibits multiple myeloma features.


name: Multiple Myeloma with Recurrent Genetic Abnormalities

description: Multiple myelomas characterized by the presence of recurring cytogenetic abnormalities.


name: Plasmacytoma-Like Post-Transplant Lymphoproliferative Disorder

description: A plasmacytoma-like hematologic malignancy that arises in a patient with a history of organ transplantation.


name: B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 with Multilineage Involvement

description: B-acute lymphoblastic leukemia associated with t(9;22)(q34.1;q11.2); BCR-ABL1 and characterized by both lymphoblastic and differentiating myeloid cell proliferation.


name: B Acute Lymphoblastic Leukemia with Germline IKZF1 Mutation

description: B-acute lymphoblastic leukemia that results from germline mutation of the IKZF1 gene.


Chronic lymphocytic leukemia stage 2

description: Risk: Intermediate; Findings: Lymphocytosis, adenopathy, and enlarged spleen and/or liver; Survival (months): 72. (from AJCC 8th Ed.)


name: Adult B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

description: A B acute lymphoblastic leukemia that occurs during adulthood. It is characterized by the presence of lymphoblasts that carry a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. It results in the production of the p190 kd or p210 kd fusion protein. It has an unfavorable clinical outcome.


Refractory B-Cell Malignant Neoplasm

description: A B-cell malignant neoplasm that is resistant to treatment.


name: Multiple Myeloma with CCND Family Translocation

description: Multiple myeloma characterized by the presence of a translocation involving a CCND family gene.


RISS Stage I Multiple Myeloma

description: Serum beta-2-microglobulin less than 3.5 mg/L and serum albumin 3.5 g/dL or more and no high-risk cytogenetics and normal LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.)


DS Stage IIB Multiple Myeloma

description: Durie/Salmon stage II multiple myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


name: Chronic Lymphocytic Leukemia with Plasmacytoid Differentiation

description: A chronic lymphocytic leukemia characterized by the presence of neoplastic lymphocytes with plasmacytoid morphology.


name: Near-Haploid B Acute Lymphoblastic Leukemia

description: B-acute lymphoblastic leukemia associated with a near haploid karyotype.


name: B Acute Lymphoblastic Leukemia with IKZF1 N159Y Mutation

description: B-acute lymphoblastic leukemia associated with IKZF1 missense mutation p.Asn159Tyr (N159Y).


name: B Acute Lymphoblastic Leukemia with UBTF-ATXN7L3/PAN3, CDX2 ("CDX2/UBTF")

description: B-acute lymphoblastic leukemia associated with concomitant CDX2 deregulation and expression of the chimeric UBTF-ATXN7L3 fusion oncoprotein. It usually affects female adolescents and young adults. The prognosis is poor following treatment with conventional chemotherapy.


name: Extramedullary Disease in Plasma Cell Myeloma

description: Infiltration of organs and soft tissues by malignant (clonal) plasma cells in patients with history of multiple myeloma. Skin, liver, lymph nodes, pleura, and central nervous system are the most frequently affected sites.


Head and Neck Plasmacytoma

description: A plasmacytoma that arises from the head and neck region.


Sinonasal Plasmacytoma

description: A plasmacytoma that arises from the sinonasal tract.


DS Stage IIA Multiple Myeloma

description: Durie/Salmon stage II multiple myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


name: Progressive Hairy Cell Leukemia Initial Treatment

description: A hairy cell leukemia requiring initial treatment because of the presence of signs of progression.  Signs of progression include cytopenia (especially if symptomatic), increasing splenomegaly, and infectious complications.  Therapy is not necessary if the patients are asymptomatic and the blood counts are maintained in an acceptable range.


name: Refractory Transformed Chronic Lymphocytic Leukemia

description: Chronic lymphocytic leukemia which has undergone histologic transformation to an aggressive diffuse large B-cell lymphoma (Richter's transformation) and has become resistant to treatment.


name: B Lymphoblastic Leukemia/Lymphoma with MYC Rearrangement

description: B-lymphoblastic leukemia/lymphoma associated with MYC gene rearrangement. The prognosis is poor.


Primary cutaneous plasmacytoma

description: A plasmacytoma that arises in the skin.


name: B Acute Lymphoblastic Leukemia with PAX5 Alteration

description: B-acute lymphoblastic leukemia associated with PAX5 gene alteration, including rearrangements, point mutations, and intragenic lesions. This is a provisional entity.


name: B Lymphoblastic Leukemia/Lymphoma with TCF3-HLF Rearrangement

description: An exceptionally rare childhood B-lymphoblastic leukemia/lymphoma associated with TCF3-HLF gene rearrangement resulting in the formation of TCF3-HLF chimeric transcription factor. The prognosis is poor.


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, JAK-STAT Activated

description: B-acute lymphoblastic leukemia, BCR-ABL1-like associated with aberrant activation of the JAK-STAT signaling pathway.


name: Chronic Lymphocytic Leukemia with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation

description: Chronic lymphocytic leukemia characterized by the presence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a better prognosis as compared to those with unmutated immunoglobulin heavy chain gene variable region rearrangements.


Plasma cell myeloma refractory

description: Multiple myeloma that is resistant to treatment.


Testicular Plasmacytoma

description: A rare plasmacytoma that arises in the testis. At presentation the involvement is usually unilateral.


name: B Acute Lymphoblastic Leukemia with Germline PAX5 Mutation

description: B-acute lymphoblastic leukemia that results from germline mutation of the PAX5 gene.


DS Stage II Plasma Cell Myeloma

description: Multiple myeloma that fits in neither stage I nor stage III.  Estimated myeloma cell mass: 0.6 to 1.2 trillion (1012)/m2 (intermediate burden).  The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL.  Impaired renal function worsens prognosis regardless of stage.  Note that the newer International Staging System defines stage II quite differently: Beta-2-microglobulin less than 3.5 and albumin less than 3.5 or beta-2-microglobulin 3.5 to less than 5.5 (median survival of 44 months).  (PDQ)


name: B Acute Lymphoblastic Leukemia with MEF2D Rearrangement

description: B-acute lymphoblastic leukemia associated with MEF2D gene rearrangement. The prognosis is poor.


Chronic lymphocytic leukemia refractory

description: Chronic lymphocytic leukemia that is resistant to treatment.


name: Transformed Chronic Lymphocytic Leukemia to Hodgkin Lymphoma

description: Histologic transformation of chronic lymphocytic leukemia to Hodgkin lymphoma.


name: Recurrent B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

description: The reemergence of B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 after a period of remission.


name: Extramedullary Disease in Multiple Myeloma Involving the Uterine Corpus

description: Infiltration of the uterine corpus by malignant (clonal) plasma cells in patients with history of multiple myeloma.


name: Childhood B Lymphoblastic Leukemia/Lymphoma

description: B lymphoblastic leukemia/lymphoma that occurs during childhood.


Multiple Myeloma with t(11;14)(q13;q32)

description: Multiple myeloma characterized by the presence of t(11;14)(q13;q32). It is the most common immunoglobulin heavy chain translocation found in multiple myeloma and results in CCND1 overexpression.


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

description: B acute lymphoblastic leukemia characterized by a gene-expression profile similar to that of BCR-ABL1-positive B acute lymphoblastic leukemia, absence of the pathognomonic BCR-ABL1 rearrangement, alterations of lymphoid transcription factor genes, and a poor outcome.


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, ABL1 Rearranged

description: B-acute lymphoblastic leukemia, BCR-ABL1-like associated with ABL1 gene rearrangement.


name: Chronic Lymphocytic Leukemia- Modified Rai Staging System

description: A term that refers to the staging of chronic lymphocytic leukemia according to modified Rai staging system. This system is mainly used in North America.


Chronic lymphocytic leukemia stage 3

description: Risk: High; Findings: Lymphocytosis and hemoglobin less than 11 g/dL; Survival (months): 30. (from AJCC 8th Ed.)


RISS Stage II Multiple Myeloma

description: Not stage I or III. (from AJCC 8th Ed.)


name: Low-Hypodiploid B Acute Lymphoblastic Leukemia

description: B-acute lymphoblastic leukemia associated with a low hypodiploid karyotype.


Multiple Myeloma by ISS Stage

description: A header term that refers to the staging of multiple myeloma according to the International Staging System.


Recurrent Burkitt Leukemia

description: The reemergence of Burkitt leukemia after a period of remission.


name: Plasma Cell Post-Transplant Lymphoproliferative Disorder

description: A plasma cell neoplasm that arises in a patient with a history of organ transplantation.


Multiple Myeloma by RISS Stage

description: A staging system for multiple myeloma based on the Revised International Staging System (RISS) criteria. This staging system does not apply to smoldering multiple myeloma (no AJCC staging system), monoclonal gammopathy of undetermined significance (no AJCC staging system), and Waldenstrom macroglobulinemia (no AJCC staging system). (from AJCC 8th Ed.)


name: B Acute Lymphoblastic Leukemia with Germline Predisposition

description: B-acute lymphoblastic leukemia that results from germline gene mutations. This category includes B-acute lymphoblastic leukemia with germline PAX5 mutation and B-acute lymphoblastic leukemia with germline IKZF1 mutation.


Adult Burkitt Leukemia

description: The leukemic counterpart of Burkitt lymphoma occurring in adults.  The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood.  This is an aggressive leukemia.


ISS Stage II Plasma Cell Myeloma

description: Multiple myeloma with blood levels of beta-2-microglobulin between 3.5 and 5.5 mg/L.


Recurrent B-Cell Malignant Neoplasm

description: The reemergence of a B-cell malignant neoplasm after a period of remission.


Plasmacytoma anaplastic

description: A plasmacytoma characterized by the presence of malignant plasma cells with anaplastic features.


name: B Acute Lymphoblastic Leukemia with MYC Rearrangement

description: B-acute lymphoblastic leukemia associated with MYC gene rearrangement. The prognosis is poor.


Refractory Burkitt Leukemia

description: Burkitt leukemia resistant to treatment.


name: Multiple Myeloma with NSD2 Translocation

description: Multiple myeloma characterized by the presence of a translocation involving the NSD2 gene.


name: Recurrent Transformed Chronic Lymphocytic Leukemia

description: The reemergence of chronic lymphocytic leukemia transformed to aggressive diffuse large B-cell lymphoma (Richter's transformation) after a period of remission.


name: Extramedullary Disease in Multiple Myeloma Involving the Skin

description: Infiltration of the skin by malignant (clonal) plasma cells in patients with history of multiple myeloma.


Advanced B-Cell Malignant Neoplasm

description: A B-cell malignant neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: B Acute Lymphoblastic Leukemia with ZNF384 Rearrangement

description: B-acute lymphoblastic leukemia associated with ZNF384 gene rearrangement. The prognosis is variable.


name: B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 with Lymphoid Only Involvement

description: B-acute lymphoblastic leukemia associated with t(9;22)(q34.1;q11.2); BCR-ABL1 and characterized by lymphoblastic proliferation without differentiating myeloid cell proliferation.


Stage C Chronic Lymphocytic Leukemia

description: Findings: Lymphocytosis, adenopathy, and enlarged spleen and/or liver; Survival (months): 72. (from AJCC 8th Ed.)


Cutaneous Chronic Lymphocytic Leukemia

description: A chronic lymphocytic leukemia that affects the skin.


DS Stage III Plasma Cell Myeloma

description: Multiple myeloma with one or more of the following: 1. Hemoglobin less than 8.5 g/dL. 2. Serum calcium greater than 12.0 mg/dL. 3. More than three lytic bone lesions. 4. High M protein production as shown by: a. IgG greater than 7.0 g/dL. b. IgA greater than 5.0 g/dL. c. Urinary kappa or lamda greater than 12.0 g/24 hours. Estimated myeloma cell mass: greater than 1.2 trillion (1012)/m2 (high burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL. b. Creatinine greater than or equal to 2.0 mg/dL. Serum beta-2-microglobulin has been shown to be a reliable marker for prognosis. Since the great majority of symptomatic myeloma patients are classified as stage III by the Durie/Salmon criteria, this staging system has not proven to be very useful for identifying the patients with intermediate and poor prognosis. Note that the newer International Staging System defines stage III quite differently: Beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months). (PDQ)


DS Stage I Plasma Cell Myeloma

description: Multiple myeloma with all of the following: 1. Hemoglobin greater than 10 g/Dl, 2. Normal serum calcium, 3. Normal bone structure, 4. Low monoclonal (or myeloma) protein (M protein) production as shown by: a. IgG less than 5.0 g/dL, b. IgA less than 3.0 g/dL, c. Urinary kappa or lamda less than 4 g/24 hours. Estimated myeloma cell mass: less than 0.6 trillion (1012)/m2 (low burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL. Impaired renal function worsens prognosis regardless of stage. Note that the newer International Staging System defines stage I quite differently: Beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months). (PDQ)


name: B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

description: A B-acute lymphoblastic leukemia (B-ALL) that does not have the cytogenetic abnormality t(9;22)(q34;q11.2). Most cases of B-ALL do not have this translocation.


DS Stage IIIA Multiple Myeloma

description: Durie/Salmon stage III multiple myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


name: B Lymphoblastic Leukemia/Lymphoma with ETV6-RUNX1-Like Features

description: B lymphoblastic leukemia/lymphoma characterized by a gene-expression profile similar to that of ETV6-RUNX1-positive B lymphoblastic leukemia/lymphoma, absence of the pathognomonic ETV6-RUNX1 rearrangement, and rearrangements or deletions of ETV6 and IKZF1 genes.


name: Recurrent B Acute Lymphoblastic Leukemia

description: The reemergence of B acute lymphoblastic leukemia after a period of remission.


RISS Stage III Multiple Myeloma

description: Serum beta-2-microglobulin 5.5 mg/L or more and high-risk cytogenetics and/or high LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.)


name: B Acute Lymphoblastic Leukemia Associated with Down Syndrome

description: A B-acute lymphoblastic leukemia that occurs in patients with Down syndrome. It usually affects young children, but it can occur in adults as well. It has an unfavorable clinical outcome. Cases of T-acute lymphoblastic leukemia in patients with Down syndrome have not been reported.


name: Hyperdiploid B Acute Lymphoblastic Leukemia

description: A B-cell acute leukemia characterized by the presence of lymphoblasts which contain more than 50 and usually less than 66 chromosomes. It is commonly seen in children and rarely in adults. It has a favorable clinical outcome.


name: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

description: B-lymphoblastic leukemias/lymphomas characterized by the absence of recurrent genetic abnormalities.


name: B Acute Lymphoblastic Leukemia with NUTM1 Rearrangement

description: B-acute lymphoblastic leukemia associated with NUTM1 gene rearrangement. The prognosis is good.


ISS Stage III Plasma Cell Myeloma

description: Multiple myeloma with beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months).  Note that the older Durie/Salmon staging system defines stage III quite differently. (PDQ)


DS Stage IB Multiple Myeloma

description: Durie/Salmon stage I multiple myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, ABL Class Rearranged

description: B-acute lymphoblastic leukemia, BCR-ABL1-like associated with rearrangement of an ABL class gene (e.g., ABL1, ABL2, CSF1R, PDGFRA, and PDGFRB).


name: Recurrent B-Cell Prolymphocytic Leukemia

description: The reemergence of a B-cell prolymphocytic leukemia after a period of remission.


name: Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of an indolent chronic lymphocytic leukemia to an aggressive diffuse large B-cell lymphoma.


name: Extramedullary Disease in Multiple Myeloma Involving the Kidney

description: Infiltration of the kidney by malignant (clonal) plasma cells in patients with history of multiple myeloma.


Multiple Myeloma with Hyperdiploidy

description: Multiple myeloma characterized by the presence of plasma cells in which the chromosomal number is greater than the normal diploid number.


Chronic lymphocytic leukemia stage 0

description: Risk: Low; Findings: Lymphocytosis only; Survival (months): more than 120. (from AJCC 8th Ed.)


name: Refractory B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

description: B acute lymphoblastic leukemia, Philadelphia chromosome negative, that does not respond to treatment.


name: B Acute Lymphoblastic Leukemia with ZNF362 Rearrangement

description: B-acute lymphoblastic leukemia associated with ZNF362 gene rearrangement. The prognosis is variable.


name: Refractory B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

description: B-acute lymphoblastic leukemia, BCR-ABL1-like that does not respond to treatment.


ISS Stage I Plasma Cell Myeloma

description: Multiple myeloma with beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months).  Note that the older Durie/Salmon staging system defines stage I quite differently. (PDQ)


name: B-lymphoblastic leukemia lymphoma BCR-ABL1-like

description: B lymphoblastic leukemia/lymphoma characterized by a gene-expression profile similar to that of BCR-ABL1-positive B lymphoblastic leukemia/lymphoma, absence of the pathognomonic BCR-ABL1 rearrangement, alterations of lymphoid transcription factor genes, and a poor outcome.


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, Not Otherwise Specified

description: B-acute lymphoblastic leukemia, BCR-ABL1-like in which further genetic/molecular characterization is not available.


Multiple Myeloma Myeloma by DS Stage

description: A header term that refers to the staging of multiple myeloma according to the Durie/Salmon staging system.


Childhood Burkitt Leukemia

description: The leukemic counterpart of Burkitt lymphoma occurring in children.  The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood.  This is an aggressive leukemia.


Nasal Cavity Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that arises from the nasal cavity.


Nasal Cavity Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the nasal cavity.


name: Nasal Cavity Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that arises from the nasal cavity.


name: Nasal Cavity Small Cell Neuroendocrine Carcinoma

description: A small cell neuroendocrine carcinoma that arises from the nasal cavity.


name: Penile Undifferentiated Pleomorphic Sarcoma

description: A rare undifferentiated pleomorphic sarcoma that occurs in the penis.


Non-Neoplastic Vision Disorder

description: A non-neoplastic disorder that causes a disturbance in normal vision. Representative examples include amblyopia, astigmatism, myopia, and cataracts.


Color Blindness, Inherited

description: Genetic based difficulty in distinguishing colors.


Optical Illusion

description: The visual perception of an image that differs from the reality of the image.


CDP-alpha-D-abequose

A CDP-D-abequose in which the anomeric centre of the pyranose fragment has alpha-configuration.


victoria blue R

An iminium salt composed of 4-{[4-(dimethylamino)phenyl][4-(ethylamino)naphthalen-1-yl]methylidene}-N,N-dimethylcyclohexa-2,5-dien-1-iminium and chloride ions in a 1:1 ratio.


name: Advanced Extracranial Malignant Solid Neoplasm

description: A malignant solid neoplasm that arises from any anatomic site other than the brain and has spread extensively to other anatomic sites or is no longer responding to treatment.


(6Z,9Z)-octadecadienoic acid

An octadecadienoic acid in which the two double bonds have Z-geochemistry and are located at positions 6 and 9.


A beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine in which the acyl group specified is hexadecanoyl.


Ciliary Body Adenocarcinoma

description: An adenocarcinoma arising from the pigmented or non-pigmented ciliary epithelium.


Stage IIB Uveal Melanoma AJCC v7

description: Stage IIB includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement.  T3a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with sclera extension and secondary glaucoma. Ciliary body and choroid: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIA Uveal Melanoma AJCC v7

description: Stage IIA includes: (T1b-d, N0, M0); (T2a, N0, M0). T1b: Iris: Tumor limited to the iris more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 with ciliary body involvement.  T1c: Iris: Tumor limited to the iris with secondary glaucoma.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T1d: Ciliary body and choroid: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T2a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with secondary glaucoma.  Ciliary body and choroid: Tumor size category 2 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Metastatic Choroid Melanoma

description: Choroid melanoma that has spread from its primary site to another anatomic site.


name: Metastatic Malignant Neoplasm in the Uvea

description: A malignant neoplasm that has spread to the uvea from another anatomic site.


Uveal Melanocytoma

description: A subtype of ciliary body, iris, and choroidal nevi. It is intensely pigmented and composed of large, plump, polyhedral cells.


Choroid Spindle Cell Type A Melanoma

description: A choroid melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


name: Uveal Melanoma by Gene Expression Profile


name: Locally Advanced Unresectable Uveal Melanoma

description: Uveal melanoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Uveal Spindle Cell Type A Melanoma

description: A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Stage III Uveal Melanoma AJCC v7

description: Stage III includes: IIIA (T2c-d, N0, M0); (T3b-c, N0, M0); (T4a, N0, M0); IIIB (T3d, N0, M0); (T4b-c, N0, M0); IIIC (T4d-e, N0, M0).  T2c: Ciliary body and choroid: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T2d: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T3b: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement. T3c: Ciliary body and choroid: Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T4a: Iris: Tumor with extrascleral extension less than or equal to 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 without ciliary body involvement and extraocular extension.  T3d: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4b: Iris: Tumor with extrascleral extension more than 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 with ciliary body involvement.  T4c: Ciliary body and choroid: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T4d: Ciliary body and choroid: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4e: Ciliary body and choroid: Any tumor size category with extraocular extension more than 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Uveal Class 2 Melanoma

description: Gene expression profiling that classifies uveal melanomas into a high-grade group.


Uveal Class 1a Melanoma

description: Uveal melanoma with low metastatic risk as defined by gene expression profiling.


Ciliary Body Nevus

description: A benign nevus that arises from the ciliary body. Only a small percentage of cases progress to ciliary body melanoma.


Stage IIIC Uveal Melanoma AJCC v7

description: Stage IIIC includes: T4d-e, N0, M0.  T4d: Ciliary body and choroid: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4e: Ciliary body and choroid: Any tumor size category with extraocular extension more than 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Refractory Uveal Melanoma

description: Uveal melanoma that is resistant to treatment.


Choroidal Ganglioneuroma

description: A rare ganglioneuroma that arises from the choroid.


Uveal Melanocytic Neoplasm

description: A melanocytic neoplasm that arises from the iris, ciliary body, and choroid. This category includes nevus and its subtype melanocytoma, and melanoma.


name: Choroidal and Ciliary Body Melanoma by AJCC v8 Stage

description: A term that refers to the staging of choroidal and ciliary body melanoma, following the rules of the TNM AJCC v8 classification system.


Unresectable Uveal Melanoma

description: Uveal melanoma that is not amenable to surgical resection.


name: Stage IIB Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IIB includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Tumor size category 2 with ciliary body involvement. T3a: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Choroid Spindle Cell Type B Melanoma

description: A choroid melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


name: Stage IIIB Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IIIB includes: (T3d, N0, M0); (T4b-c, N0, M0). T3d: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter.  T4b: Tumor size category 4 with ciliary body involvement. T4c: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Uveal Class 1b Melanoma

description: Uveal melanoma with intermediate metastatic risk as defined by gene expression profiling.


name: Ciliary Body Spindle Cell Type B Melanoma

description: A ciliary body melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Stage II Uveal Melanoma AJCC v7

description: Stage II includes: IIA (T1b-d, N0, M0); (T2a, N0, M0); IIB (T2b, N0, M0); (T3a, N0, M0).  T1b: Iris: Tumor limited to the iris more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 with ciliary body involvement.  T1c: Iris: Tumor limited to the iris with secondary glaucoma.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T1d: Ciliary body and choroid: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T2a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with secondary glaucoma.  Ciliary body and choroid: Tumor size category 2 without ciliary body involvement and extraocular extension. T2b: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement.  T3a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with sclera extension and secondary glaucoma. Ciliary body and choroid: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Stage III Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage III includes: IIIA (T2c-d, N0, M0); (T3b-c, N0, M0); (T4a, N0, M0); IIIB (T3d, N0, M0); (T4b-c, N0, M0); IIIC: (T4d-e, N0, M0). T2c: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T2d: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T3b: Tumor size category 3 with ciliary body involvement. T3c: Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T4a: Tumor size category 4 without ciliary body involvement and extraocular extension. T3d: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter.  T4b: Tumor size category 4 with ciliary body involvement. T4c: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T4d: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T4e: Any tumor size category with extraocular extension more than 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Stage I Uveal Melanoma AJCC v7

description: Stage I includes: T1a, N0, M0.  T1a: Iris: Tumor limited to the iris not more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement and extraocular extension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Stage IIA Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IIA includes: (T1b-d, N0, M0); (T2a, N0, M0).  T1b: Tumor size category 1 with ciliary body involvement.  T1c: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter.  T1d: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T2a: Tumor size category 2 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


name: Stage I Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage I includes: T1a, N0, M0. T1a: Tumor size category 1 without ciliary body involvement and extraocular extension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 8th ed.)


name: Stage IV Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IV includes: (Any T, N1, M0); (Any T, Any N, M1a-c). N1: Regional lymph node metastasis or discrete tumor deposits in the orbit. M0: No distant metastasis. M1a: Distant metastasis, with the largest diameter of the largest metastasis measuring 3 cm or less. M1b: Distant metastasis, with the largest diameter of the largest metastasis measuring 3.1-8.0 cm. M1c: Distant metastasis, with the largest diameter of the largest metastasis measuring 8.1 cm or more.  (AJCC 8th ed.)


name: Ciliary Body Spindle Cell Type A Melanoma

description: A ciliary body melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Stage IIIB Uveal Melanoma AJCC v7

description: Stage IIIB includes: (T3d, N0, M0); (T4b-c, N0, M0).  T3d: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4b: Iris: Tumor with extrascleral extension more than 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 with ciliary body involvement.  T4c: Ciliary body and choroid: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Metastatic Uveal Melanoma

description: Uveal melanoma that has spread from its primary site to another anatomic site.


Iris Mixed Cell Melanoma

description: A melanoma arising from the iris. It is characterized by the presence of a mixture of spindle A melanoma cells, spindle B melanoma cells, and epithelioid melanoma cells.


Stage IV Uveal Melanoma AJCC v7

description: Stage IV includes: (Any T, N1, M0); (Any T, Any N, M1a-c).  N1: Regional lymph node metastasis. M1a: Distant metastasis, with the largest diameter of the largest metastasis measuring 3 cm or less.  M1b: Distant metastasis, with the largest diameter of the largest metastasis measuring 3.1-8.0 cm.  M1c: Distant metastasis, with the largest diameter of the largest metastasis measuring 8.0 cm or more.  (AJCC 7th ed.)


Benign neoplasm of uveal tract

description: A neoplasm that arises from the uvea and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential..


name: Stage IIIC Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IIIC includes: T4d-e, N0, M0. T4d: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T4e: Any tumor size category with extraocular extension more than 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


name: Metastatic Malignant Neoplasm in the Iris

description: A malignant neoplasm that has spread to the iris from another anatomic site.


name: Stage II Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage II includes: IIA (T1b-d, N0, M0); (T2a, N0, M0); IIB (T2b, N0, M0); (T3a, N0, M0).  T1b: Tumor size category 1 with ciliary body involvement.  T1c: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter.  T1d: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T2a: Tumor size category 2 without ciliary body involvement and extraocular extension. T2b: Tumor size category 2 with ciliary body involvement. T3a: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Uveal Melanoma by AJCC v7 Stage

description: A term that refers to the staging of uveal melanoma, following the rules of the TNM AJCC v7 classification system.


Uveal Spindle Cell Type B Melanoma

description: A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Uveal Class 1 Melanoma

description: Gene expression profiling that classifies uveal melanomas into a low-grade group.


Uveal Nevus

description: A benign nevus derived from melanocytes of the uveal tract. Only a small percentage of cases progress to uveal melanoma.


Advanced Uveal Melanoma

description: Uveal melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Iridociliary Melanoma

description: Melanoma that affects both the iris and ciliary body.


Iris Epithelioid Cell Melanoma

description: An iris melanoma characterized by the presence of malignant large epithelioid melanocytes.


name: Metastatic malignant neoplasm to ciliary body

description: A malignant neoplasm that has spread to the ciliary body from another anatomic site.


Conjunctival keratoacanthomas

description: A rapidly growing neoplasm that arises from the conjunctiva. It is characterized by a proliferation of squamous cells, acanthosis, keratinization, dysplasia, increased mitotic activity, and a central crater filled with keratinocytes. It is considered a variant of well-differentiated squamous cell carcinoma with distinct clinical behavior.


Conjunctival Spindle Cell Carcinoma

description: A variant of conjunctival squamous cell carcinoma characterized by the presence of malignant spindle cells and/or pleomorphic cells.


Stage II Fallopian Tube Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Fallopian Tube Cancer AJCC v8

description: Stage IIA includes: T2a, N0, M0. T2a: Fallopian tube cancer with extension and/or implants on the uterus and/or fallopian tube(s) and/or ovaries. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIB Fallopian Tube Cancer AJCC v8

description: Stage IIB includes: T2b, N0, M0. T2b: Fallopian tube cancer with tumor extension to and/or implants on other pelvic tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Laryngeal Paraganglioma

description: An extra-adrenal parasympathetic paraganglioma arising from paraganglia adjacent to the larynx.  Patients may present with hoarseness and dysphagia.


Finding by Site or System

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A term that refers to the classification of a clinical or laboratory finding according to the anatomic site or system that is involved.


Muscle Weakness Right-Sided

description: A reduction in the strength of the muscles in the right side of the body.


Congenital urinary tract obstruction

description: An impediment to the flow of urine along the urinary tract, which is present at birth.


Atrial Couplet by ECG Finding

description: An electrocardiographic finding in which two premature atrial complexes occur sequentially. (CDISC)


Vanishing twin syndrome

description: A multiple pregnancy that over time is spontaneously reduced by one or more embryos which are then resorbed.


Bronchial Obstruction

description: Blockage of a bronchus passage most often by bronchial secretions and exudates.


name: AV Block Second Degree Mobitz Type II by ECG Finding


Jejunal Obstruction

description: Blockage of the normal flow of the small intestinal contents in the jejunum.


Todd's Paralysis

description: A neurological condition experienced by individuals with epilepsy, in which a seizure is followed by a brief period of temporary paralysis.


name: Pregnancy-Related Nausea and/or Vomiting

description: Nausea and/or vomiting co-occurring with pregnancy.


Carpal Spasm

description: A spasmodic contraction of the muscles of the hands, especially the wrists, such as during alkalosis or tetany. (ACC/AHA)


New daily persistent headache

description: A bilateral, unremitting headache of mild to moderate intensity that occurs daily and may be associated with photophobia, phonophobia, or mild nausea.


Pregnancy Finding

description: Symptoms, signs, diagnostic examinations or a test results in a pregnant mother.


Aldosterone Synthase Deficiency Type 2

description: Aldosterone synthase deficiency characterized by decreased conversion of 18-hydroxycorticosterone to aldosterone.


AV Block Third Degree by ECG Finding

description: An electrocardiographic finding of complete failure of atrial electrical impulse conduction to the ventricles. This is manifested on the ECG by disassociation of atrial and ventricular rhythms. The atrial rate must be faster than the ventricular rate. (CDISC)


Lumbar Puncture Headache

description: Headache in erect position, after lumbar puncture; due to lowering of intracranial pressure by leakage of cerebrospinal fluid through the needle tract.


Obstruction of trachea

description: Blockage of the lumen of the trachea. Causes include secretions, foreign bodies, and tumors.


Lower gastrointestinal hemorrhage

description: Bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus).


Caries into Dentin

description: Tooth decay that extends through the enamel into the dentin layer.


Intrapartum Shock

description: Severe loss of blood pressure leading to inadequate tissue perfusion after the onset of labor but prior to the delivery of the fetus.


Neurogenic shock (disorder)

description: Shock resulting from neurogenic vasodilation, which can be produced by cerebral trauma or hemorrhage, spinal cord injury, deep general or spinal anesthesia, or toxic central nervous system depression.


name: Brachial plexus palsy due to birth trauma

description: Birth injury to the brachial plexus. It results in paralysis of the muscles of the shoulder, arm, and hand. It manifests as lack of mobility in the arm, usually in the first week of life. In the majority of cases there is spontaneous recovery.


Pedal Spasm

description: A spasmodic contraction of the muscles of the feet, especially the ankles, such as during alkalosis or tetany. (ACC/AHA)


Syncope due to Acquired Heart Lesion

description: A condition in which syncope occurs due to a disease process of the heart with which the patient was not born. (ACC/AHA)


Superficial injury of cornea

description: Trauma to the corneal epithelium.


Rectal hemorrhage

description: Bleeding originating from the rectal wall and discharged from the anus.


Shock, Traumatic

description: Any shock produced by trauma.


Psychogenic tremor

description: An involuntary, compulsive, repetitive stereotyped movement.


Infertility Related to Treatment

description: Infertility that is associated with a treatment.


Chemical pregnancy

description: Pregnancy loss before 5th week of gestation with no gestational sac visible on ultrasonogram.


Cardiogenic Shock Related to COVID-19

description: Cardiogenic shock in a patient with probable or confirmed acute COVID-19.


Insulin Coma

description: A hypoglycemia-induced comatose state resulting from a large dose of exogenous insulin.


Dissecting aortic aneurysm

description: A dissecting aneurysm formed between the intimal and medial layers of the aortic wall due to a tear in the tunica intima.


Persistent Atrial Flutter

description: An electrocardiographic finding of atrial flutter which is present during the entire recording.


Maternal Hypotension

description: A symptomatic decrease in baseline systolic or diastolic blood pressure in a pregnant woman that requires intervention.


Hypotension due to Cardiac Dysfunction

description: A condition in which there is hypotension because of inadequate pumping function of the heart. (ACC/AHA)


name: Right Ventricular Hypertrophy by ECG Finding

description: An electrocardiographic finding suggestive of a hypertrophied right ventricle, characterized by large R wave amplitudes in the right precordial leads and secondary findings of right atrial enlargement, right axis deviation, and typical pattern of ST depression and T wave inversion in the right precordial leads. (CDISC)


Intestinal Stoma Obstruction

description: A blockage of the intestinal stoma.


Secondary pulmonary hypertension

description: Pulmonary hypertension that is caused by an underlying condition.


Reproductive System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the reproductive system.


name: Growth hormone neurosecretory dysfunction

description: Reduced spontaneous secretion of growth hormone with normal range response to growth hormone provocative stimuli.


name: High Grade Atrioventricular Block by ECG Finding

description: An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by two or more consecutive non-conducted P waves. (CDISC)


Ureter Compression

description: Narrowing of the luminal diameter of one or both ureters due to extrinsic pressure.


name: Postpartum Mental or Behavioral Disorder

description: A maternal mental or behavioral disorder that occurs in the period following the birth of a child and extending up to six weeks after delivery.


Esophageal bleeding

description: Bleeding originating from the esophagus.


Hyperreninemic hypoaldosteronism

description: Hypoaldosteronism characterized by impaired secretion of aldosterone, despite increased renin activity. This condition may be caused by chronic or critical illness, aldosterone synthase deficiency or other genetic conditions.


name: Immunodeficiency due to Functional Defects

description: An indication that an immunodeficiency disorder is caused by the presence of immune cells that are dysfunctional.


Moderate Hepatic Insufficiency

description: Findings indicating moderate impairment of liver function.


Depressed Level Of Consciousness

description: A neurologic state characterized by decreased ability to perceive and respond.


name: Chronic Maternal Hypertension with Superimposed Preeclampsia

description: Chronic hypertension in association with preeclampsia.


Reproductive System Hemorrhage

description: Bleeding originating in the organs and tissue that aid in reproduction.


Vascular Headaches

description: Headache caused by abnormal functioning of the vascular system.


Urostomy Obstruction

description: Blockage of the urostomy.


Sinus Bradycardia by ECG Finding

description: An electrocardiographic finding of abnormally slow heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC)


Anterior segment ischemia

description: Compromise of blood supply to the anterior segment of the eye.


T Wave Peaked by ECG Finding

description: An electrocardiographic finding in which the T wave appears increased in amplitude and cresting at a point.


Corneal Abrasions

description: Injury to the epithelium of the cornea.


Eye and Ear Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the organs of special sense.


Testosterone Excess

description: Abnormally high level of testosterone.


Urinary System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the urinary system.


name: Cardiogenic Shock Stage D Related to COVID-19

description: Clinical signs of deteriorating cardiogenic shock in a patient with probable or confirmed acute COVID-19. Failure to respond to initial interventions to restore adequate perfusion after 30 minutes. Further more intensive therapies are required, including the addition of mechanical circulatory support.


Anticipatory Vomiting

description: A situation in which an individual vomits prior to a medical treatment, commonly chemotherapy, as part of a conditioned/learned response after having previously experienced nausea and/or vomiting as a direct result of that same (or a similar) treatment.


Upper gastrointestinal hemorrhage

description: Bleeding originating from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach).


Visceral Artery Ischemia

description: Decreased blood supply to the small or large intestine due to narrowing or blockage of a visceral (mesenteric) artery. The ischemia results to the damage of the intestinal tissues. It may be chronic, caused by atherosclerosis or acute, secondary to the formation of a thrombus or embolus in the mesenteric arterial lumen. In chronic ischemia, patients present with abdominal pain manifested in a short time after a meal and weight loss. In acute ischemia, patients present with sudden and acute abdominal pain, nausea and vomiting, and blood in the stool.


Obstruction of colon

description: Blockage of the normal flow of the intestinal contents in the colon.


Caries Restricted to Enamel

description: Tooth decay that is restricted to the enamel layer.


Duodenal hemorrhage

description: Bleeding originating from the duodenum.


Congenital Neurogenic Bladder

description: Neurogenic bladder, the cause of which is present at birth.


AV Block Second Degree by ECG Finding

description: An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles. This is manifest on the ECG by regular P waves which intermittently are not followed by QRS complexes. (CDISC)


Borderline hypertension

description: Blood pressure in the zone between the highest normal level and the level that is considered hypertensive.


Jacksonian Seizure

description: A partial motor seizure that begins in a single area of the body and progresses to include other areas on the same side of the body.


Rheumatic tricuspid valve stenosis

description: Tricuspid valve stenosis secondary to rheumatic fever.


name: Cardiogenic Shock with Distributive Shock Related to COVID-19


Hemorrhagic complication of pregnancy

description: Bleeding occurring during pregnancy.


Ectopic Atrial Rhythm by ECG Finding

description: An electrocardiographic finding of a regular atrial rhythm with atrial rate of less than 101 beats per minute which does not originate in the sinus node, and which is characterized by P waves whose morphology differs from the P wave morphology during sinus rhythm. (CDISC)


Ventricular Arrhythmia by ECG Finding

description: An electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles.


name: Coronary Artery Aneurysm Related to COVID-19

description: Coronary artery aneurysm in a patient with probable or confirmed acute COVID-19.


Alterations in Smell or Taste

description: A change to taste and/or olfactory perception resulting from disease processes or treatment.


Non-Febrile Seizure

description: A seizure that is not associated with fever.


name: Psychosexual dysfunction with inhibited sexual excitement

description: Recurrent and persistent suppression of sexual excitement during sexual activity.


Pregnancy, Angular

description: A type of pregnancy which starts with the embryo in the interstitial section of the fallopian tube, which then grows into the uterine cavity.


Cecal Hemorrhage

description: Bleeding originating in the cecum.


name: Female infertility associated with anovulation

description: A menstrual cycle in which no ovulation occurs.


Congenital growth hormone deficiency

description: Growth hormone deficiency the cause of which is present at birth.


Arrhythmogenic Syncope

description: A condition in which syncope occurs due to an arrhythmia. (ACC/AHA)


Melanocortin Pathway Defect

description: An abnormality in the biochemical pathway involving the melanocortins, a group of peptide hormones associated with anorexogenic signaling in the brain and hypothalamus.


Delayed Orgasm

description: Sexual dysfunction characterized by a delay in climax.


Endocrine System Signs and Symptoms

description: Patient complaints, physical findings, laboratory findings referable to the endocrinologic system.


Drug-induced hypotension

description: A condition in which there is hypotension because of the effects of a medication or other substance. (ACC/AHA)


Hormone Imbalance

description: An abnormal finding indicating that the level of a particular hormone is not within the expected normal values.


Syncope due to Congenital Heart Lesion

description: A condition in which syncope occurs due to a disease process of the heart with which the patient was born. (ACC/AHA)


Rheumatic mitral stenosis

description: Mitral valve stenosis secondary to rheumatic fever.


name: Headache due to external compression of head

description: Headache resulting from pressure applied to the cutaneous nerves of the head.


Hypoaldosteronism, Hyporeninemic

description: Hypoaldosteronism characterized by hyperkalemia and inappropriately low renin activity. This condition may be caused by a primary renal disorder, drugs or autoimmune processes.


Blocked premature atrial contraction

description: An electrocardiographic finding of premature atrial complexes which are not conducted to the ventricle, and which are not followed by a QRS complex. (CDISC)


name: Congenital isolated adrenocorticotropic hormone deficiency

description: Adrenocorticotropic hormone (ACTH) deficiency due to mutation(s) in the TBX19 gene.


Aneurysm, Ruptured

description: An aneurysm that has burst, resulting in hemorrhage into adjacent tissues.


Malignant Bowel Obstruction

description: Obstruction of the bowel by an advanced malignant tumor. It is a complication especially in patients with an advanced abdominal malignant tumor.


Ileal hemorrhage

description: Bleeding originating from the ileal wall.


Paroxysmal atrial flutter

description: An electrocardiographic finding of atrial flutter which occurs intermittently during the recording. Other rhythms which may be present are sinus rhythm, junctional rhythm, or an atrial paced rhythm.


Atrial bigeminy

description: An electrocardiographic finding of a sinus beat followed by a premature atrial complexes for three or more consecutive cycles; a regularly irregular rhythm of normal and abnormal P waves in a 1-1 ratio. (CDISC)


Small bowel obstruction

description: Blockage of the normal flow of the small intestinal contents.


Limb injury

description: Trauma to an arm or leg.


Aldosterone Synthase Deficiency

description: An autosomal recessive condition due to mutation(s) in the CYP11B2 gene that results in decreased activity of mitochondrial cytochrome P450 11B2 with reduced aldosterone synthesis and salt wasting.


First Trimester Antepartum Hemorrhage

description: Excessive blood loss within the first trimester but prior to onset of labor.


Aneurysm, Bacterial

description: An aneurysm caused by an infection.


Endometrioma

description: A cystic form of endometriosis affecting the ovary.  It may or may not be associated with endometriosis in other areas in the pelvis.


Marked Sinus Bradycardia by ECG Finding

description: An electrocardiographic tracing demonstrating sinus bradycardia, with a heart rate lower than an acceptable, predetermined threshold.  Different thresholds, for rate and/or duration, may apply to different patient populations.


Non-Rh Blood Group Isoimmunization

description: The mother develops antibodies against red blood cell non-Rhesus antigens. This may lead to potential fetal adverse outcomes such as anemia.


Blighted ovum

description: Pregnancy loss with visible gestational sac or yolk sac or both but no visible embryo on ultrasonogram.


In-Hospital Cardiac Arrest

description: Cardiac arrest which occurs in the hospital setting.


Threatened premature labor

description: Frequent painful contractions prior to 37 weeks of gestation without cervical change.


Atrial trigeminy

description: An electrocardiographic finding of two sinus beats followed by a premature atrial complex for 3 or more consecutive cycles; a regularly irregular rhythm of normal and abnormal P waves in a 2-1 ratio. (CDISC)


Nodal Arrhythmia by ECG Finding

description: An electrocardiographic finding of an arrhythmia originating from within the atrioventricular node.


Congenital stenosis of pulmonary valve

description: Pulmonary valve stenosis that is present at birth.


name: Atrioventricular Nodal Reentry Tachycardia by ECG Finding

description: An electrocardiographic finding of a regular supraventricular tachycardia due to reentry within the AV node. It is characterized by P waves which typically occur nearly simultaneously with the QRS complex, resulting in a P wave which is obscured by the QRS, merged with the QRS or which may follow the QRS. (CDISC)


Acquired Neurogenic Bladder

description: Neurogenic bladder, the cause of which is not present at birth.


Migraine-triggered seizure

description: A seizure triggered by a migraine.


Musculoskeletal Finding

description: Symptoms, physical examination results, and/or laboratory rest results related to the muscles and bones.


name: Cardiac Arrest/Arrhythmia Etiology Unknown

description: An episode of cardiac arrest or arrhythmia where the etiology was unknown. (ACC)


Diverticulosis

description: A finding indicating the presence of multiple pouches, usually in the colonic or gastric wall.


Acquired Urinary Tract Obstruction

description: A urinary tract obstruction, the cause of which is not present at birth.


Adrenal Androgen Excess

description: Excessive secretion of the androgen hormones dehydroepiandrosterone (DHEA), DHEA sulfate, and androstenedione, from the adrenal gland. Clinical manifestations may include virilization.


name: Cardiogenic Shock Stage E Related to COVID-19

description: Clinical signs of extremis in a patient with cardiogenic shock and probable or confirmed acute COVID-19. Highly unstable, often with circulatory collapse and/or refractory cardiac arrest with ongoing cardiopulmonary resuscitation (CPR). They are being supported by multiple simultaneous acute interventions including extracorporeal membrane oxygenation (ECMO)-facilitated CPR (eCPR).


Male Reproductive System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the male reproductive system.


Embryonic Loss

description: Pregnancy loss at 6 weeks, 0 days to 9 weeks, 6 days of gestation of an embryo with crown-rump length less than 10 mm and no cardiac activity visible on ultrasonogram.


Rh Incompatibility

description: A complication during pregnancy; it occurs when the mother is Rh-negative and the infant is Rh-positive. This complication generally does not affect first-born Rh-positive babies. Rh-positive newborn babies from subsequent pregnancies develop complications of Rh incompatibility which include hemolysis, jaundice, enlarged liver and spleen, petechiae, hypotonia, neurologic damage, and heart problems.


Limb Cramp

description: An involuntary contraction of a muscle in an extremity.


Postpartum Complication

description: Any adverse event that arises in the six week period immediately following the delivery of a fetus.


Junctional bradycardia

description: An electrocardiographic finding of a junctional rhythm with a heat rate which is abnormally low. (CDISC)


Bleeding from anus

description: Bleeding originating from the anal area.


Subclinical Seizure

description: A seizure with no apparent symptoms.


Syphilitic aneurysm of aorta

description: Aneurysm of the aorta secondary to syphilis.


Endocrine System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the endocrine system.


Arteriovenous fistula aneurysm

description: A bulge in a weakened vessel wall segment of an arteriovenous fistula.


Insulin Shock

description: A hypoglycemic reaction to overdosage of insulin, a skipped meal, or strenuous exercise in an insulin-dependent diabetic.


name: Proximal Left Anterior Descending Coronary Artery Stenosis

description: A narrowing of the proximal portion of the left main coronary artery, usually considered significant if the stenosis is 70% or greater.


Tearing

description: Shedding of tears.


Fine corneal edema

description: Corneal edema of inflammatory origin associated with contact lens wear and morphologically characterized by presence of epithelial microcysts. Microcysts are small (typically 10-50 microns in diameter), clear, irregularly shaped high refractive inclusions that form in the basal layers of the epithelium and move towards the anterior surface of the cornea, surrounding epithelial haze. The cause of microcytic edema is related to the physical presence of contact lenses and possibly a mechanical effect of lens wear.


Achalasia

description: Failure of the smooth muscle fibers of the gastrointestinal tract to relax at any one point of junction of one part with another.


Erythema of the Oropharyngeal Mucosa

description: Erythema of the mucus membranes lining the part of the pharynx located between the soft palate and the upper portion of the epiglottis.


left main coronary artery stenosis

description: Percent luminal narrowing of the left main coronary artery, at the point of maximal stenosis of the left main coronary artery.


Eye muscle weakness

description: A reduction in the strength of the eye muscles.


Ileal Obstruction

description: Blockage of the normal flow of the small intestinal contents in the ileum.


name: Ventricular Tachycardia/Ventricular Fibrillation Arrest

description: A cardiac arrest attributed to ventricular tachycardia or ventricular fibrillation.


name: AV Block Second Degree Mobitz Type I by ECG Finding

description: An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by a progressively lengthening PR interval prior to the block of an atrial impulse. (CDISC)


Familial Male Precocious Puberty

description: Early development of isosexual secondary characteristics in boys, due to autosomal dominant mutations in the LHCGR gene.


Pigmentary Change in Skin

description: Abnormal skin pigmentation.


Antepartum Uterine Rupture

description: An acute symptomatic tearing of the uterine wall prior to the onset of labor.


Dissecting Abdominal Aortic Aneurysm

description: A dissecting aneurysm in the portion of the descending aortic wall that is within the abdomen.


Chronic peritoneal effusion (disorder)

description: Persistent or recurring accumulation of fluid in the peritoneal cavity.


Vaginal Discharge

description: Normal or abnormal secretions from the vagina. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. Causes of abnormal vaginal discharge include infectious agents (e.g., Neisseria gonorrhea, Chlamydia trachomatis, Trichomonas, and Candida albicans), the presence of foreign bodies, and cervical or vaginal cancer.


Erb-Duchenne Paralysis

description: Weakness or paralysis of muscles in the arm due to damage in the upper brachial plexus.


Cardioinhibitory Syncope

description: A condition in which neurally-mediated syncope occurs in which the blood pressure falls and heart rate falls. (ACC/AHA)


Nail Changes

description: Alteration of the normal characteristics of the fingernails or toenails. Examples include thickening, thinning, deformity, and separation from the nail bed.


Foot Or Leg Hypoesthesia

description: Consisting of abnormally decreased sensitivity, particularly to touch in the foot or leg.


Hormone Resistance

description: A finding indicating decreased tissue sensitivity to a hormone.


Heart Block by ECG Finding

description: An electrocardiographic finding of blocked cardiac electrical impulses along the fibers normally responsible for impulse conduction.


name: Idiopathic Isolated Growth Hormone Deficiency

description: Insufficient secretion of growth hormone for which no underlying cause can be found.


name: Acquired Adrenocorticotropic Hormone Deficiency

description: Adrenocorticotropic hormone (ACTH) deficiency, the cause of which is not present at birth.


Hemorrhage of digestive system

description: Bleeding originating from any part of the digestive system.


Syncope due to Migraine

description: A condition in which syncope occurs associated with the occurrence of cerebral vasospasm. (ACC/AHA)


Precipitous Birth

description: Unexpectedly sudden vaginal delivery.


Caries, Region Unknown

description: Tooth decay of an unspecified location.


name: Cardiogenic Shock Stage B Related to COVID-19

description: Clinical signs of shock or compensated shock in a patient with probable or confirmed acute COVID-19 wherein they may be volume overloaded, tachycardic, and/or hypotensive but no evidence of hypoperfusion on physical exam or laboratory studies.


Malignant ascites

description: Accumulation of fluid in the peritoneal cavity resulting from the growth of primary or metastatic malignant neoplasms in the peritoneum.


Vasoconstriction

description: Vasoconstriction involves narrowing of a blood vessel lumen due to smooth muscle contraction in the vessel wall and leads to decreased blood flow.


Connective and Soft Tissue Injury

description: Damage inflicted on the soft tissues and their supporting structures as the direct or indirect result of an external force, with or without disruption of structural continuity.


Motor Manifestations

description: The presence of an alteration in the ability to move one's body or any body parts in accordance with one's intent.


Ureterovesical Obstruction

description: Blockage of the opening between the ureter and the bladder resulting in the reduction or prevention of the urine flow from the ureter to the bladder.


name: Supraventricular Arrhythmia by ECG Finding

description: An electrocardiographic finding of an arrhythmia originating in the atrium, AV node or AV junction.


Electrocardiographic Finding

description: Graphic representation and categorization of the electrical vectors produced by the depolarization and repolarization of myocardial tissue.


Unspecified antepartum hypertension

description: High blood pressure in the period of time preceding labor and delivery.


Primary Cough Headache

description: Headache triggered by coughing or straining in the absence of an intracranial disorder.


Seizure Related to COVID-19

description: Seizure in a patient with probable or confirmed acute COVID-19.


Digestive System Signs and Symptoms

description: Signs and symptoms associated with disturbances within the digestive system, which includes the stomach, intestines and all associated organs that aid in digestion.


Intestinal Stoma Site Hemorrhage

description: A finding of blood leakage from the intestinal stoma.


name: Cardiogenic Shock Stage C Related to COVID-19

description: Clinical signs of cardiogenic shock with clinical evidence of hypotension and hypoperfusion (cold and wet) on physical examination that requires intervention (inotrope, pressor or mechanical support, including extracorporeal membrane oxygenation (ECMO)) beyond volume resuscitation to restore normal perfusion in a patient with probable or confirmed acute COVID-19.  Invasive hemodynamics may demonstrate the classic depressed cardiac index associated with cardiogenic shock.


name: Paroxysmal Atrial Fibrillation by ECG Finding

description: An electrocardiographic tracing demonstrating intermittent atrial fibrillation in the presence of sinus rhythm, junctional rhythm, or an atrial paced rhythm.


Jejunal hemorrhage

description: Bleeding originating from the jejunal wall.


Uncomplicated hypertension

description: A condition of high blood pressure without resulting clinical disorders.


Vascular stenosis

description: Narrowing of the lumen of an artery or vein.


Valvular stenosis

description: Narrowing of the opening of one or more of the four valves of the heart.


Page kidney

description: Hypertension resulting from activation of the renin-angiotensin system in response to prolonged compression of the renal parenchyma and blood vessels.


name: Congenital obstruction of ureteropelvic junction

description: Complete or partial blockage of the ureter at the point where it enters the kidney that is present at birth.


Breastfeeding Jaundice

description: Yellow coloring of skin, mucous membranes and eyes in an otherwise healthy breast-fed newborn due to insufficient intake of maternally-expressed milk. It commonly appears four to seven days after birth.


Carcinomatous ascites

description: Accumulation of fluid in the peritoneal cavity resulting from the growth of primary or metastatic carcinoma in the peritoneum.


Atrial Flutter by ECG Finding

description: An electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 beats per minute. Multiple P waves typically appear in the inferior leads in a saw tooth like pattern between the QRS complexes. (CDISC)


Maternal complications of pregnancy

description: The development of a problematic medical situation that occurs during pregnancy.


name: Left Main Coronary Artery Stenosis, Percentage

description: The percentage of narrowing of the left main coronary artery.


Extraocular Muscle Paresis

description: A slight or incomplete paralysis of an extraocular muscle.


T Waves Biphasic by ECG Finding

description: An electrocardiographic finding of a T wave with both positive and negative components. (CDISC)


Primary Exertional Headache

description: Headache triggered by exercise.


Decreased Sperm Count

description: A finding indicating the presence of a lower than expected number of spermatozoa in the semen.


Atrial Premature Complex by ECG Finding

description: An electrocardiographic finding of an ectopic impulse originating in the atria and not specifically in the sinus node. The P wave morphology of these complexes is often different from a sinus P wave and the RR intervals preceding these complexes is also shorter than those of the regular beats. (CDISC)


Active Caries

description: Tooth decay that is increasing in size or scope.


Hemorrhagic ascites

description: Accumulation of hemorrhagic fluid in the peritoneal cavity.


Diastolic hypertension

description: Hypertension characterized diastolic blood pressure greater than 90 mmHg on two occasions.


Aldosterone Synthase Deficiency Type 1

description: Aldosterone synthase deficiency characterized by decreased conversion of corticosterone to 18-hydroxycorticosterone.


Brachial Plexus Palsy

description: An injury that results in paralysis of the muscles of the shoulder, arm, and hand. It manifests as lack of mobility in the arm. In the majority of cases there is spontaneous recovery.


Bone injury

description: Trauma to bone.


Endoleak

description: Persistent blood flow/pressure in the aneurysm sac following an endovascular aneurysm repair (EVAR) procedure.


Blacking Out

description: A temporary loss of consciousness or a temporary state of altered consciousness that results in memory loss.


Bradycardia Arrest

description: Cardiac arrest that was a result of bradycardia.


Connective and Soft Tissue Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the connective and soft tissue.


Fetal Hypoxemia

description: Abnormally low arterial blood oxygen concentration in a fetus.


Unspecified renovascular hypertension

description: High blood pressure caused by renal artery stenosis.


Nervous System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the nervous system.


Neurogenic Orthostatic Hypotension

description: Orthostatic hypotension due to autonomic dysfunction. Primary neurogenic orthostatic hypotension (nOH) may be associated with disorders such as Parkinson disease (PD) and multiple system atrophy (MSA) whereas secondary nOH may be seen in peripheral neuropathies.


Delayed Postpartum Hemorrhage

description: Excessive blood loss between 24 hours after delivery through four weeks that requires intervention.


Chronic Maternal Hypertension

description: Hypertension that predates pregnancy.


Junctional premature complex (disorder)

description: An electrocardiographic finding of an ectopic impulse originating in the AV junction presenting as a QRS complex of supraventricular origin which is not preceded by a P wave. (CDISC)


Abnormal pregnancy

description: A pregnancy that is complicated and affected by an abnormal finding or disease condition in either the fetus and/or the mother.


name: Immunodeficiency due to Quantitative Defects

description: An indication that an immunodeficiency disorder is caused by a partial or complete loss of one or more of the hematopoietic cell lineages that are involved in host defense.


Drug-induced Syncope

description: A condition in which syncope occurs due to the ingestion or administration of a chemical substance. (ACC/AHA)


Postoperative Hypertension

description: A transient increase in blood pressure following a surgical procedure.


Fecal Occult Blood

description: Blood in the feces that is not visibly apparent.


Endobronchial Obstruction

description: Partial or complete blockage of the bronchial lumen by a pathological process that occurs within the bronchus.


Third Trimester Antepartum Hemorrhage

description: Excessive blood loss within the third trimester but prior to onset of labor.


Corneal burn

description: Chemical or radiant injury to the cornea.


Right Ventricular Dysfunction

description: Impairment of the right ventricular function associated with low ejection fraction and decreased motility of the right ventricular wall.


Ventricular Dysfunction

description: Impairment of the ventricle to either fill or eject adequately.


Arteriovenous graft aneurysm

description: A bulge in a weakened wall segment of an arteriovenous graft.


Atrial Fibrillation by ECG Finding

description: An electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregularly irregular ventricular response. (CDISC)


name: Intra-Atrial Conduction Delay by ECG Finding

description: An electrocardiographic finding of a delay in impulse propagation through the atria. This is characterized by broad P waves which are often biphasic in V1. (CDISC)


Systolic Hypertension

description: Abnormally high systolic blood pressure.


name: Associated Pulmonary Arterial Hypertension

description: Pulmonary hypertension that results from another disorder (e.g., connective tissue disorder).


ST Segment Abnormality by ECG Finding

description: An electrocardiographic finding of ST segment elevation or depression.


Epibulbar Osseous Choristoma

description: Epibulbar choristoma composed of mature bone.


Ovarian Hyperandrogenism

description: Increased production of androgens by the ovaries.


Resuscitated Cardiac Arrest Event

description: Cardiac arrest that is reversed, usually by CPR and/or defibrillation or cardioversion, or cardiac pacing.


Disturbance of Skin Sensation

description: Disruption of the normal functioning of the sensory nerves in the skin.


Follicle stimulating hormone deficiency

description: Subnormal concentration of follicle stimulating hormone.


Antibiotic-associated diarrhea

description: Diarrhea that is associated with current or recent antibiotic use.


Stomach Cramp

description: An involuntary muscular contraction in the stomach. Often, this cramp is spasmodic and can be uncomfortable.


Opioid-Induced Constipation

description: Constipation that results from, or follows, treatment with an opioid or opioid-containing medication.


Paroxysmal atrioventricular block

description: An electrocardiographic finding of the sudden onset of transient AV block, which is often associated with preexisting conduction disorders. (CDISC)


Arm Or Hand Hypoesthesia

description: Consisting of abnormally decreased sensitivity, particularly to touch in the arm or hand.


Surgical Shock

description: Hypoperfusion of body tissues occurring during or after a surgical procedure, and resulting in cellular injury and vital organ dysfunction.


Female Reproductive System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the female reproductive system.


Duodenal ulcer with hemorrhage

description: Bleeding from a ruptured blood vessel in a duodenal ulcer.


Skin Discoloration

description: Abnormal skin coloration.


Syncope with Exertion

description: A condition in which syncope occurs either during or after physical activity. (ACC/AHA)


Vasodepressor Syncope

description: A condition in which neurally-mediated syncope occurs in which the blood pressure falls and the heart rate increases. (ACC/AHA)


name: Cardiac Arrest Prior to Percutaneous Coronary Intervention

description: Cardiac arrest which occurs before a percutaneous coronary intervention can take place. (ACC)


Toxic Erythema of Chemotherapy

description: Painful red or purple patches, edematous plaques or blisters on the hands, feet, extremities or intertriginous regions; the onset can occur days to months after receiving chemotherapy.


Neonatal Vaginal Discharge

description: Secretions which may be thin or tenacious, mucoid or glairy, grayish or milky, occasionally blood tinged, that originate in the vagina and are a consequence of the residual influence of maternal estrogen.


Injury of musculoskeletal system

description: Damage to the muscles, bones and their supportive structural attachments.


Immediate Postpartum Hemorrhage

description: Cumulative blood loss of greater than or equal to 1000 ML or blood loss accompanied by signs or symptoms of hypovolemia within 24 hours following the birth process (includes intrapartum loss). (reVITALize)


Infectious Hidradenitis

description: Hidradenitis that is caused by an infectious agent, usually a bacterium.


Skin Type

description: A distinctive characteristic of the skin marked by the amount of sebum secreted by sebaceous glands.


Binocular Diplopia

description: Perception of two images secondary to misalignment of the eyes.


name: Atrioventricular Reentrant Tachycardia by ECG Finding

description: An electrocardiographic finding of a regular supraventricular tachycardia which utilizes an atrioventricular bypass tract as its retrograde limb (orthodromic tachycardia) or as its antegrade limb (antidromic tachycardia). QRS complexes during sinus rhythm may show preexcitation. During orthodromic tachycardia the preexcitation is not present and a retrograde P wave may appear after the QRS complex. During antidromic tachycardia the QRS complex is preexcited. (CDISC)


Hemorrhagic Shock

description: Hypoperfusion of body tissues due to acute blood loss, resulting in cellular injury and vital organ dysfunction.


name: Infertility Related to Medical Condition

description: Infertility that is associated with a medical condition.


name: Hypertension Secondary To Endocrine Disorders

description: Evidence of hypertension secondary to endocrine disorders.


Pregnancy, Prolonged

description: A gestation that lasts greater than or equal to 42 weeks and 0 days.


Benign congenital hypotonia

description: Mild hypotonia that usually appears early in infancy and has a favorable outcome. It is not a manifestation of another disorder that may cause hypotonia (e.g., cerebral palsy or muscular dystrophy).


vaginal bleeding during pregnancy

description: Hemorrhage from the vagina that may range from light spotting to heavy flow during pregnancy.


Secondary caries

description: A carious lesion adjacent to an existing restoration.


Reflex

description: An automatic instinctive unlearned reaction to a stimulus.


T Waves Flat by ECG Finding

description: An electrocardiographic finding in which the T wave appears decreased in amplitude.


Focal Motor Weakness

description: Impairments of brain function, the nerve or spinal cord that affect a specific region of the body.


psychogenic syncope

description: A condition in which syncope occurs due to a conversion disorder. (ACC/AHA)


Peritumoral Brain Edema

description: An intracranial edema that develops around a tumor in the meninges or brain.


Phakomatous Choristoma

description: An extremely rare developmental abnormality characterized by the presence of ectopic lens tissue usually in the medial lower eyelid, although cases exclusively involving the orbit have been reported.


Maternal Fever

description: The elevation of body temperature in a pregnant mother above 38 degrees C or more than 101 degrees F, and may be indicative of an infection.


Muscle Weakness Trunk

description: A reduction in the strength of the trunk muscles.


Blood Pressure Finding

description: A test result that reports the diastolic and systolic pressure of the blood.


name: Syncope with High Risk Cardiac Characteristics

description: A sudden loss of consciousness with loss of postural tone not related to anesthesia with high risk characteristics. High risk characteristics include non-ischemic dilated cardiomyopathy, or ischemic heart disease with significant ventricular dysfunction, hypertrophic cardiomyopathy, Brugada Syndrome, or Long QT Syndrome. (ACC)


Berry Aneurysm

description: A small cerebral artery aneurysm, characterized by a saccular appearance, that typically forms at the junction of vessels in the circle of Willis.


Cisplatin-Induced Tinnitus

description: Tinnitus that is caused by exposure to cisplatin.


Grade 3 Seizure, ASTCT ICANS

description: Any clinical seizure focal or generalized that resolves rapidly or nonconvulsive seizures on EEG that resolve with intervention, as defined by the American Society for Transplantation and Cellular Therapy (ASTCT) and the Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) Consensus Grading for Adults.


name: Congenital obstruction of ureteral orifice

description: Complete or partial blockage of the ureter at the point where it enters the bladder that is present at birth.


Digestive System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the digestive system.


Muscle Weakness Left-Sided

description: A reduction in the strength of the muscles in the left side of the body.


Ventricular Tachycardia by ECG Finding

description: An electrocardiographic finding of three or more consecutive complexes of ventricular organ with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC)


Neurological Signs and Symptoms

description: A term that refers to the clinical manifestations resulting from pathologic processes that affect the central and peripheral nervous system.


Blood Clot

description: An aggregation of blood factors, primarily platelets and fibrin with entrapment of cellular elements, frequently causing vascular obstruction at the point of its formation.


name: Cardiac Arrest Requiring Cardiopulmonary Resuscitation

description: Cardiac arrest that is treated by CPR and/or defibrillation, regardless of outcome.


Integumentary System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the integumentary system.


Diplopia, Unilateral

description: Perception of more than one image when viewing with one eye.


Neutrophilic Eccrine Hidradenitis

description: Painful red or pink edematous nodules most commonly found on the palmar and/or plantar regions.


Jaundice, Hemolytic

description: Jaundice occurring as a result of red blood cell rupture.


Immune-Mediated Diarrhea

description: Diarrhea caused by an immune reaction to an antigen, including a therapeutically administered agent.


name: Pericardial Effusion Related to COVID-19

description: Pericardial effusion in a patient with probable or confirmed acute COVID-19.


Arrhythmia by ECG Finding

description: An arrhythmia that is detected on an electrocardiograph.


Carious Dentin

description: Tooth decay that has invaded the dentin, creating dentin that is partially demineralized and containing mineral crystals in the tubules.


Atrioventricular junctional rhythm

description: An electrocardiographic finding of a rhythm which originates in the AV junction and results in a normal heart rate. It is characterized by retrograde P waves which may be obscured by or may follow the QRS complexes. The QRS complexes may be narrow or may demonstrate aberration. (CDISC)


Ectopic atrial pacemaker

description: An electrocardiographic finding of a supraventricular arrhythmia characterized by 3 or more distinct P wave morphologies with an isoelectric baseline, variable PR intervals and no predominant atrial rhythm. The ventricular rate is typically below 100 beats per minute. (CDISC)


Faceplant

description: A syncopal event in which there is no attempt to protect oneself from the effects of the fall.


Gastric hemorrhage

description: Bleeding from the gastric wall.


Acral Erythema

description: Reddening of the palmar and plantar regions of the body with occasional involvement of the distal extremities.


Grade 4 Seizure, ASTCT ICANS

description: Life-threatening prolonged seizure (>5 min); or repetitive clinical or electrical seizures without return to baseline in between seizures, as defined by the American Society for Transplantation and Cellular Therapy (ASTCT) and the Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) Consensus Grading for Adults.


Congenital Testicular Failure

description: Testicular failure, the cause of which is present at birth.


Complex tic

description: A tic that involves multiple muscles or muscle groups, or words or sentences.


name: Multifocal Atrial Premature Complex by ECG Finding

description: An electrocardiographic finding of premature atrial complexes which have 2 or more distinct morphologies, suggesting origin at more than one atrial site. (CDISC)


description: Diminished mental function after chemotherapy.


Postpartum Shock

description: Severe loss of blood pressure leading to inadequate tissue perfusion after the delivery of the fetus.


name: Acquired solitary multilocular renal cyst

description: A single cyst in the kidney with several compartments.


Intraocular Pressure

description: The fluid pressure within the eye.