dermatophytosis

description: A common fungal infection of the stratum corneum of the skin, hair, or nails by a dermatophyte. It is characterized by itching, inflammation, redness of the skin, small papular vesicles, central clearing, fissures, scaling, and/or hair loss in the affected area.


name: TGFR1_HUMAN TGF-beta receptor type-1 (sprot)

description: A TGF-beta receptor type-1 that is encoded in the genome of human.


name: TFAP4_HUMAN Transcription factor AP-4 (sprot)

description: A transcription factor AP-4 that is encoded in the genome of human.


name: UD11_HUMAN UDP-glucuronosyltransferase 1A1 (sprot)

description: A UDP-glucuronosyltransferase 1A1 that is encoded in the genome of human.


name: DPOE2_HUMAN DNA polymerase epsilon subunit 2 (sprot)

description: A DNA polymerase epsilon subunit 2 that is encoded in the genome of human.


VANILLYL ALCOHOL

A monomethoxybenzene that is 2-methoxyphenol substituted by a hydroxymethyl group at position 4.


name: GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-5 that is encoded in the genome of human.


sodium succinate (anhydrous)

A sodium salt that is the disodium salt of succinic acid. The hexahydrate form is used as an ingredient of topical preparations for the treatment of cataract.


Cellulose, microcrystalline

A (1->4)-beta-D-glucan (cellulose) in crystalline form with a structure consisting of several hundred to over ten thousand D-glucose residues joined by beta(1->4) glycosidic linkages.


name: PDE4B_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4B (sprot)

description: A 3',5'-cyclic-AMP phosphodiesterase 4B that is encoded in the genome of human.


A 2-hydroxy steroid that consists of 17beta-estradiol having an additional hydroxy group at position 2.


name: MMP12_HUMAN Macrophage metalloelastase (sprot)

description: A macrophage metalloelastase that is encoded in the genome of human.


name: TRI63_HUMAN E3 ubiquitin-protein ligase TRIM63 (sprot)

description: An E3 ubiquitin-protein ligase TRIM63 that is encoded in the genome of human.


T-cell non-Hodgkin lymphoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A non-Hodgkin lymphoma of T-cell lineage. It includes the T lymphoblastic lymphoma and the mature T- and NK-cell lymphomas. -- 2003


orlistat

A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.


morbid obesity

description: An excess of body weight, normally defined as an individual with a body mass index greater than 35 or a body weight greater than one hundred percent of ideal body weight.


DIECKOL

A phlorotannin isolated from a brown alga Ecklonia cava which exhibits antioxidant, hepatoprotective and anticoagulant activities.


name: CD24_HUMAN Signal transducer CD24 (sprot)

description: A signal transducer CD24 that is encoded in the genome of human.


name: PRKDC_HUMAN DNA-dependent protein kinase catalytic subunit (sprot)

description: A DNA-dependent protein kinase catalytic subunit that is encoded in the genome of human.


name: PDK3_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (sprot)

description: A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial that is encoded in the genome of human.


choline

A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.


name: B2LA1_HUMAN Bcl-2-related protein A1 (sprot)

description: A Bcl-2-related protein A1 that is encoded in the genome of human.


name: TRIPC_HUMAN E3 ubiquitin-protein ligase TRIP12 (sprot)

description: An E3 ubiquitin-protein ligase TRIP12 that is encoded in the genome of human.


neomycin

A broad-spectrum highly toxic antibiotic or mixture of antibiotics produced by a streptomyces (Streptomyces fradiae) and used medically especially to treat local infections.


name: SMCA2_HUMAN Probable global transcription activator SNF2L2 (sprot)

description: A probable global transcription activator SNF2L2 that is encoded in the genome of human.


name: HBEGF_HUMAN Proheparin-binding EGF-like growth factor (sprot)

description: A proheparin-binding EGF-like growth factor that is encoded in the genome of human.


name: RBM28_HUMAN RNA-binding protein 28 (sprot)

description: An RNA-binding protein 28 that is encoded in the genome of human.


BREFELDIN A

A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.


name: HTAI2_HUMAN Oxidoreductase HTATIP2 (sprot)

description: An oxidoreductase HTATIP2 that is encoded in the genome of human.


name: KDM6B_HUMAN Lysine-specific demethylase 6B (sprot)

description: A lysine-specific demethylase 6B that is encoded in the genome of human.


arachidonic acid

A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.


name: SODC_HUMAN Superoxide dismutase [Cu-Zn] (sprot)

description: A superoxide dismutase [Cu-Zn] that is encoded in the genome of human.


name: ADCK1_HUMAN AarF domain-containing protein kinase 1 (sprot)

description: An AarF domain-containing protein kinase 1 that is encoded in the genome of human.


iron deficiency anemia

description: Anemia caused by low iron intake, inefficient iron absorption in the gastrointestinal tract, or chronic blood loss.


tianeptine

A member of the class of dibenzothiazepines that is 3-chloro-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide substituted by a (6-carboxyhexyl)amino group at position 11.


name: HOME1_HUMAN Homer protein homolog 1 (sprot)

description: A homer protein homolog 1 that is encoded in the genome of human.


TSP4_HUMAN Thrombospondin-4 (sprot)

A thrombospondin-4 that is encoded in the genome of human.


name: AP2M1_HUMAN AP-2 complex subunit mu (sprot)

description: An AP-2 complex subunit mu that is encoded in the genome of human.


name: NHRF2_HUMAN Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (sprot)

description: A Na(+)/H(+) exchange regulatory cofactor NHE-RF2 that is encoded in the genome of human.


differentiated thyroid carcinoma

description: Differentiated thyroid carcinoma (DTC), also known as papillary or follicular thyroid carcinoma, is a slow-growing malignancy usually presenting in adults as an asymptomatic thyroid mass.


A pyrazolopyrimidine that is 1H-pyrazolo[3,4-d]pyrimidine which is substituted by a cyclopentyl, 1H-pyrrolo[2,3-b]pyridin-5-yl, and amino groups at positions 1, 3 and 4, respectively. It is a dual inhibitor of tyrosine and phosphoinositide kinases and exhibits anti-cancer properties.


salmeterol

A phenol having a hydroxymethyl group at C-2 and a 1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl group at C-4; derivative of phenylethanolamine.


name: APC_HUMAN Adenomatous polyposis coli protein (sprot)

description: An adenomatous polyposis coli protein that is encoded in the genome of human.


name: S22A7_HUMAN Solute carrier family 22 member 7 (sprot)

description: A solute carrier family 22 member 7 that is encoded in the genome of human.


pancreatic ductal adenocarcinoma

description: An infiltrating adenocarcinoma that arises from the epithelial cells of the pancreas. It affects males more often than females and the patients are usually over 50 years of age. Microscopically it is characterized by the presence of glandular (ductal) differentiation and desmoplastic stroma formation. Signs and symptoms include pain, loss of weight, and jaundice. It grows rapidly and is usually detected after it has metastasized to other anatomic sites. The prognosis is usually poor.


name: IRF1_HUMAN Interferon regulatory factor 1 (sprot)

description: An interferon regulatory factor 1 that is encoded in the genome of human.


name: IRF3_HUMAN Interferon regulatory factor 3 (sprot)

description: An interferon regulatory factor 3 that is encoded in the genome of human.


lymphoid leukemia

description: A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. This category includes precursor or acute lymphoblastic leukemias and chronic leukemias.


interstitial cystitis

description: A rare chronic debilitating urogenital disease characterized by urinary frequency, urgency, and pelvic pain.


hyperhomocysteinemia

description: A serious metabolic condition caused by mutations in the MTHFR gene, medications, or nutritional deficiency. It results in increased levels of homocysteine in the blood. Patients with this condition are at an increased risk for recurrent blood clots formation and cardiovascular accidents.


oligoastrocytoma

description: A WHO grade II tumor composed of a conspicuous mixture of two distinct neoplastic cell types morphologically resembling the tumor cells in oligodendroglioma and diffuse astrocytoma. (WHO)


name: SLMAP_HUMAN Sarcolemmal membrane-associated protein (sprot)

description: A sarcolemmal membrane-associated protein that is encoded in the genome of human.


UBC_HUMAN Polyubiquitin-C (sprot)

A polyubiquitin-C that is encoded in the genome of human.


autoimmune hemolytic anemia

description: Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which various types of auto-antibodies are directed against red blood cells causing their survival to be shortened and resulting in hemolytic anemia.


name: gastric neuroendocrine tumor, well differentiated, low or intermediate grade

description: A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the stomach.


name: ZEB2_HUMAN Zinc finger E-box-binding homeobox 2 (sprot)

description: A zinc finger E-box-binding homeobox 2 that is encoded in the genome of human.


antiphospholipid syndrome

description: A disorder caused by the presence of autoantibodies directed against phospholipids, causing a hypercoaguable state, which may result in blood clots, stroke, heart attack, and in women, significant pregnancy-related complications, including miscarriage and still birth. The syndrome is often associated with other autoimmune disorders, most commonly lupus erythematosus, and infections, including syphilis and Lyme disease.


malignant hyperthermia of anesthesia

description: A pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gasses such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, to stresses such as vigorous exercise and heat.


name: NLK_HUMAN Serine/threonine-protein kinase NLK (sprot)

description: A serine/threonine-protein kinase NLK that is encoded in the genome of human.


name: TCF7_HUMAN Transcription factor 7 (sprot)

description: A transcription factor 7 that is encoded in the genome of human.


cytidine

A pyrimidine nucleoside in which cytosine is attached to ribofuranose via a beta-N(1)-glycosidic bond.


name: CCL4_HUMAN C-C motif chemokine 4 (sprot)

description: A C-C motif chemokine 4 that is encoded in the genome of human.


name: RNF4_HUMAN E3 ubiquitin-protein ligase RNF4 (sprot)

description: An E3 ubiquitin-protein ligase RNF4 that is encoded in the genome of human.


UBB_HUMAN Polyubiquitin-B (sprot)

A polyubiquitin-B that is encoded in the genome of human.


Hypercapnia

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Abnormally elevated blood carbon dioxide (CO2) level.


name: FUBP1_HUMAN Far upstream element-binding protein 1 (sprot)

description: A far upstream element-binding protein 1 that is encoded in the genome of human.


name: SFTA1_HUMAN Pulmonary surfactant-associated protein A1 (sprot)

description: A pulmonary surfactant-associated protein A1 that is encoded in the genome of human.


name: FGFR3_HUMAN Fibroblast growth factor receptor 3 (sprot)

description: A fibroblast growth factor receptor 3 that is encoded in the genome of human.


name: BBS4_HUMAN Bardet-Biedl syndrome 4 protein (sprot)

description: A Bardet-Biedl syndrome 4 protein that is encoded in the genome of human.


disopyramide

A monocarboxylic acid amide that is butanamide substituted by a diisopropylamino group at position 4, a phenyl group at position 2 and a pyridin-2-yl group at position 2. It is used as a  anti-arrhythmia drug.


name: FGF9_HUMAN Fibroblast growth factor 9 (sprot)

description: A fibroblast growth factor 9 that is encoded in the genome of human.


name: PDS5B_HUMAN Sister chromatid cohesion protein PDS5 homolog B (sprot)

description: A sister chromatid cohesion protein PDS5 homolog B that is encoded in the genome of human.


Prader-Willi syndrome

description: Prader-Willi syndrome is a rare genetic disorder characterized by hypothalamic-pituitary abnormalities with severe hypotonia during the neonatal period and first two years of life and the onset of hyperphagia with a risk of morbid obesity during infancy and adulthood, learning difficulties and behavioral problems or severe psychiatric problems.


D-homoserine lactone

The D-enantiomer of homoserine lactone.


tacrolimus

A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.


name: WNK3_HUMAN Serine/threonine-protein kinase WNK3 (sprot)

description: A serine/threonine-protein kinase WNK3 that is encoded in the genome of human.


name: 4EBP1_HUMAN Eukaryotic translation initiation factor 4E-binding protein 1 (sprot)

description: A eukaryotic translation initiation factor 4E-binding protein 1 that is encoded in the genome of human.


ammonium

An onium cation obtained by protonation of ammonia.


MIOX_HUMAN Inositol oxygenase (sprot)

An inositol oxygenase that is encoded in the genome of human.


FINC_HUMAN Fibronectin (sprot)

A fibronectin that is encoded in the genome of human.


name: VPS51_HUMAN Vacuolar protein sorting-associated protein 51 homolog (sprot)

description: A vacuolar protein sorting-associated protein 51 that is encoded in the genome of human.


name: CAVN3_HUMAN Caveolae-associated protein 3 (sprot)

description: A caveolae-associated protein 3 that is encoded in the genome of human.


atazanavir

A heavily substituted carbohydrazide that is an antiretroviral drug of the protease inhibitor (PI) class used to treat infection of human immunodeficiency virus (HIV).


name: PGES2_HUMAN Prostaglandin E synthase 2 (sprot)

description: A prostaglandin E synthase 2 that is encoded in the genome of human.


name: GSTP1_HUMAN Glutathione S-transferase P (sprot)

description: A glutathione S-transferase P that is encoded in the genome of human.


name: CADM1_HUMAN Cell adhesion molecule 1 (sprot)

description: A cell adhesion molecule 1 that is encoded in the genome of human.


UV-sensitive syndrome

description: UV-sensitive syndrome is a condition that is characterized by sensitivity to the ultraviolet (UV) rays in sunlight. Even a small amount of sun exposure can cause a sunburn in affected individuals. In addition, these individuals can have freckles, dryness, or changes in coloring (pigmentation) on sun-exposed areas of skin after repeated exposure. Some people with UV-sensitive syndrome have small clusters of enlarged blood vessels just under the skin (telangiectasia), usually on the cheeks and nose. Although UV exposure can cause skin cancers, people with UV-sensitive syndrome do not have an increased risk of developing these forms of cancer compared with the general population.


name: PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 11 that is encoded in the genome of human.


name: K1C18_HUMAN Keratin, type I cytoskeletal 18 (sprot)

description: A keratin, type I cytoskeletal 18 that is encoded in the genome of human.


name: TSG6_HUMAN Tumor necrosis factor-inducible gene 6 protein (sprot)

description: A tumor necrosis factor-inducible gene 6 protein that is encoded in the genome of human.


carboplatin

A platinum coordination entity with cis square-planar geometry in which  platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand.


name: PDX1_HUMAN Pancreas/duodenum homeobox protein 1 (sprot)

description: A pancreas/duodenum homeobox protein 1 that is encoded in the genome of human.


ribose

Any aldopentose where the open-chain form has all the hydroxy groups on the same side in the Fischer projection. Occurrs in two enantiomeric forms, D- and L-ribose, of which only the former is found in nature.


WNT1_HUMAN Proto-oncogene Wnt-1 (sprot)

A proto-oncogene Wnt-1 that is encoded in the genome of human.


name: S22AB_HUMAN Solute carrier family 22 member 11 (sprot)

description: A solute carrier family 22 member 11 that is encoded in the genome of human.


TPSN_HUMAN Tapasin (sprot)

A tapasin that is encoded in the genome of human.


name: DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (sprot)

description: A DNA (cytosine-5)-methyltransferase 1 that is encoded in the genome of human.


name: SLIT3_HUMAN Slit homolog 3 protein (sprot)

description: A slit homolog 3 protein that is encoded in the genome of human.


name: MBOA4_HUMAN Ghrelin O-acyltransferase (sprot)

description: A ghrelin O-acyltransferase that is encoded in the genome of human.


CALM1_HUMAN Calmodulin-1 (sprot)

A calmodulin (human) that is a translation product of the CALM1 gene.


name: KLF5_HUMAN Krueppel-like factor 5 (sprot)

description: A krueppel-like factor 5 that is encoded in the genome of human.


NOX4_HUMAN NADPH oxidase 4 (sprot)

An NADPH oxidase 4 that is encoded in the genome of human.


name: FABPL_HUMAN Fatty acid-binding protein, liver (sprot)

description: A fatty acid-binding protein, liver that is encoded in the genome of human.


Cerebral cortical atrophy

description: Atrophy of the cortex of the cerebrum.


name: MRP3_HUMAN ATP-binding cassette sub-family C member 3 (sprot)

description: An ATP-binding cassette sub-family C member 3 that is encoded in the genome of human.


trandolapril

A heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension.


CHLORPROMAZINE HYDROCHLORIDE

The hydrochloride salt of chlorpromazine.


medroxyprogesterone

An acetate ester resulting from the formal condensation of the 17alpha-hydroxy group of medroxyprogesterone with the carboxy group of acetic acid. A widely used progestin in menopausal hormone therapy and in progestogen-only birth control.


CROCIN

A diester that is crocetin in which both of the carboxy groups have been converted to their gentiobiosyl esters. It is one of the water-soluble yellow-red pigments of saffron and is used as a spice for flavouring and colouring food. Note that in India, the term 'Crocin' is also used by GlaxoSmithKline as a brand-name for paracetamol.


phosphatidylethanolamine (18:0/20:1)

A phosphatidylethanolamine 38:1 in which the acyl group at C-1 contains 18 carbons and no double bonds while that at C-2 contains 20 carbons and 1 double bond.


name: MD2L1_HUMAN Mitotic spindle assembly checkpoint protein MAD2A (sprot)

description: A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of human.


name: REPI1_HUMAN Replication initiator 1 (sprot)

description: A replication initiator 1 that is encoded in the genome of human.


name: IKZF2_HUMAN Zinc finger protein Helios (sprot)

description: A zinc finger protein Helios that is encoded in the genome of human.


name: TISB_HUMAN mRNA decay activator protein ZFP36L1 (sprot)

description: An mRNA decay activator protein ZFP36L1 that is encoded in the genome of human.


name: KLHL6_HUMAN Kelch-like protein 6 (sprot)

description: A kelch-like protein 6 that is encoded in the genome of human.


(R)-tolvaptan

The (R)-enantiomer of tolvaptan.


hepatic encephalopathy

description: Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.Signs and symptomsmay be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may includepersonality or moodchanges, intellectual impairment, abnormal movements,a depressed level of consciousness, and other symptoms.There are several theories regarding the exact cause, butdevelopment of the condition isprobablyat least partiallydue to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis.


UCN2_HUMAN Urocortin-2 (sprot)

A urocortin-2 that is encoded in the genome of human.


saquinavir

An aspartic acid derivative obtained by formal condensation of the primary amino group of (2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-ylamine with the carboxy group of N(2)(-quinolin-2-ylcarbonyl)-L-asparagine. An inhibitor of HIV-1 protease.


endocrine exophthalmos

description: Progressive inflammation and damage to tissues around the eyes, especially extraocular muscle, connective, and fatty tissue occurring in patients with hyperthyroidism or a history of hyperthyroidism due to Graves’ disease.


name: PAR2_HUMAN Proteinase-activated receptor 2 (sprot)

description: A proteinase-activated receptor 2 that is encoded in the genome of human.


Adipocyte hypertrophy

description: An increase in mean adipocyte cell size. This feature can be measured by determining the average cell diameter of adipocytes microscopically using abdominal subcutaneous adipose tissue obtained by biopsy.


name: LETM1_HUMAN Mitochondrial proton/calcium exchanger protein (sprot)

description: A mitochondrial proton/calcium exchanger protein that is encoded in the genome of human.


name: PKN1_HUMAN Serine/threonine-protein kinase N1 (sprot)

description: A serine/threonine-protein kinase N1 that is encoded in the genome of human.


ZALUZANIN C

A sesquiterpene lactone that is decahydroazuleno[4,5-b]furan-2(3H)-one substituted by methylidene groups at positions 3, 6 and 9 and a hydroxy group at position 8.


tetracaine

A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.


name: PYDC1_HUMAN Pyrin domain-containing protein 1 (sprot)

description: A pyrin domain-containing protein 1 that is encoded in the genome of human.


name: TOE1_HUMAN Target of EGR1 protein 1 (sprot)

description: A target of EGR1 protein 1 that is encoded in the genome of human.


piperazine

An azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions.


name: SC6A9_HUMAN Sodium- and chloride-dependent glycine transporter 1 (sprot)

description: A sodium- and chloride-dependent glycine transporter 1 that is encoded in the genome of human.


NID2_HUMAN Nidogen-2 (sprot)

A nidogen-2 that is encoded in the genome of human.


name: LOXL2_HUMAN Lysyl oxidase homolog 2 (sprot)

description: A lysyl oxidase homolog 2 that is encoded in the genome of human.


NPM_HUMAN Nucleophosmin (sprot)

A nucleophosmin that is encoded in the genome of human.


glycolaldehyde

The glycolaldehyde derived from ethylene glycol. The parent of the class of glycolaldehydes.


name: RS6_HUMAN Small ribosomal subunit protein eS6 (sprot)

description: A small ribosomal subunit protein eS6 that is encoded in the genome of human.


name: TXNIP_HUMAN Thioredoxin-interacting protein (sprot)

description: A thioredoxin-interacting protein that is encoded in the genome of human.


name: GLD2_HUMAN Poly(A) RNA polymerase GLD2 (sprot)

description: A poly(A) RNA polymerase GLD2 that is encoded in the genome of human.


name: CPEB1_HUMAN Cytoplasmic polyadenylation element-binding protein 1 (sprot)

description: A cytoplasmic polyadenylation element-binding protein 1 that is encoded in the genome of human.


lipoic acid

The (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties.


valdecoxib

A member of the class of isoxazoles that is isoxazole which is substituted at positions 3, 4 and 5 by phenyl, p-sulfamoylphenyl and methyl groups, respectively. A selective cyclooxygenase 2-inhibitor, it used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of arthritis from 2001 until 2005, when it was withdrawn following concerns of an associated increased risk of heart attack and stroke.


name: FOXL2_HUMAN Forkhead box protein L2 (sprot)

description: A forkhead box protein L2 that is encoded in the genome of human.


name: PIAS1_HUMAN E3 SUMO-protein ligase PIAS1 (sprot)

description: An E3 SUMO-protein ligase PIAS1 that is encoded in the genome of human.


ANIDULAFUNGIN

A semisynthetic echinocandin anti-fungal drug. It is active against Aspergillus and Candida species and is used for the treatment of invasive candidiasis.


limb ischemia

description: A ischemia that involves the limb.


riociguat

A carbamate ester that is the methyl ester of {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamic acid. It is used for treatment of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension


name: GHC1_HUMAN Mitochondrial glutamate carrier 1 (sprot)

description: A mitochondrial glutamate carrier 1 that is encoded in the genome of human.


name: NR4A2_HUMAN Nuclear receptor subfamily 4 group A member 2 (sprot)

description: A nuclear receptor subfamily 4 group A member 2 that is encoded in the genome of human.


hydromorphone

A  morphinane alkaloid that is a hydrogenated ketone derivative of morphine. A semi-synthetic drug, it is a centrally acting pain medication of the opioid class.


panic disorder

description: An anxiety disorder characterized by multiple unexpected panic attacks with persistent concern of recurring attacks. Panic disorder may or may not be accompanied by agoraphobia.


name: C1QBP_HUMAN Complement component 1 Q subcomponent-binding protein, mitochondrial (sprot)

description: A complement component 1 Q subcomponent-binding protein, mitochondrial that is encoded in the genome of human.


name: HABP2_HUMAN Hyaluronan-binding protein 2 (sprot)

description: A hyaluronan-binding protein 2 that is encoded in the genome of human.


ACTG_HUMAN Actin, cytoplasmic 2 (sprot)

An actin, cytoplasmic 2 that is encoded in the genome of human.


name: C99L2_HUMAN CD99 antigen-like protein 2 (sprot)

description: A CD99 molecule-like protein 2 that is encoded in the genome of human.


escitalopram

A 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has S-configuration at the chiral centre. It is the active enantiomer of citalopram.


name: OSBL6_HUMAN Oxysterol-binding protein-related protein 6 (sprot)

description: An oxysterol-binding protein-related protein 6 that is encoded in the genome of human.


name: CACO2_HUMAN Calcium-binding and coiled-coil domain-containing protein 2 (sprot)

description: A calcium-binding and coiled-coil domain-containing protein 2 that is encoded in the genome of human.


name: ARNT_HUMAN Aryl hydrocarbon receptor nuclear translocator (sprot)

description: An aryl hydrocarbon receptor nuclear translocator that is encoded in the genome of human.


fomepizole

A member of the class of  pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.


name: MSRB1_HUMAN Methionine-R-sulfoxide reductase B1 (sprot)

description: A methionine-R-sulfoxide reductase B1 that is encoded in the genome of human.


L-homocysteine

A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.


TRIB3_HUMAN Tribbles homolog 3 (sprot)

A tribbles homolog 3 that is encoded in the genome of human.


Hyperhidrosis

description: Abnormal excessive perspiration (sweating) despite the lack of appropriate stimuli like hot and humid weather.


PKHG4_HUMAN Puratrophin-1 (sprot)

A puratrophin-1 that is encoded in the genome of human.


VINC_HUMAN Vinculin (sprot)

A vinculin that is encoded in the genome of human.


name: CSMD1_HUMAN CUB and sushi domain-containing protein 1 (sprot)

description: A CUB and sushi domain-containing protein 1 that is encoded in the genome of human.


laryngeal carcinoma

description: Carcinoma that arises from the laryngeal epithelium. More than 90% of laryngeal carcinomas are squamous cell carcinomas. The remainder are adenoid cystic carcinomas, mucoepidermoid carcinomas and carcinomas with neuroendocrine differentiation.


An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.


name: MED14_HUMAN Mediator of RNA polymerase II transcription subunit 14 (sprot)

description: A mediator of RNA polymerase II transcription subunit 14 that is encoded in the genome of human.


IL13_HUMAN Interleukin-13 (sprot)

An interleukin-13 that is encoded in the genome of human.


name: NOD2_HUMAN Nucleotide-binding oligomerization domain-containing protein 2 (sprot)

description: A nucleotide-binding oligomerization domain-containing protein 2 that is encoded in the genome of human.


imiquimod

An imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.


name: CD3E_HUMAN T-cell surface glycoprotein CD3 epsilon chain (sprot)

description: A CD3 epsilon that is encoded in the genome of human.


A galactosylceramide sulfate in which the sulfo group is located at position 3 and the ceramide N-acyl group is specified as (R)-2-hydroxylignoceroyl.


FBX5_HUMAN F-box only protein 5 (sprot)

An F-box only protein 5 that is encoded in the genome of human.


name: SHC1_HUMAN SHC-transforming protein 1 (sprot)

description: An shc-transforming protein 1 that is encoded in the genome of human.


name: ZIC1_HUMAN Zinc finger protein ZIC 1 (sprot)

description: A zinc finger protein ZIC 1 that is encoded in the genome of human.


name: EAA4_HUMAN Excitatory amino acid transporter 4 (sprot)

description: An excitatory amino acid transporter 4 that is encoded in the genome of human.


ethyltrimethylammonium iodide

A quarternary ammonium salt whose basic unit comprises an ethyltrimethylammonium cation and an iodide anion.


oxycodone

A semisynthetic opioid of formula C18H21NO4 that is derived from thebaine.  It is a moderately potent opioid analgesic, generally used for relief of moderate to severe pain.


Diminished mental health

description: A reduction in the subjective feeling of mental well being.


Dysuria

description: Painful or difficult urination.


MASLINIC ACID

A pentacyclic triterpenoid that is olean-12-ene substituted by hydroxy groups at positions 2 and 3 and a carboxy group at position 28 (the 2alpha,3beta stereoisomer). It is isolated from Olea europaea and Salvia canariensis and exhibits anti-inflammatory, antioxidant and antineoplastic activity.


tiaprofenic acid

An aromatic ketone that is thiophene substituted at C-2 by benzoyl and at C-4 by a 1-carboxyethyl group.


NTF3_HUMAN Neurotrophin-3 (sprot)

A neurotrophin-3 that is encoded in the genome of human.


infectious disease

description: A disorder directly resulting from the presence and activity of a microbial, viral, or parasitic agent in humans. It can be transmitted by direct or indirect contact.


AQP3_HUMAN Aquaporin-3 (sprot)

An aquaporin-3 that is encoded in the genome of human.


RBX2_HUMAN RING-box protein 2 (sprot)

A RING-box protein 2 that is encoded in the genome of human.


name: PARD3_HUMAN Partitioning defective 3 homolog (sprot)

description: A partitioning defective 3 that is encoded in the genome of human.


name: JAM3_HUMAN Junctional adhesion molecule C (sprot)

description: A junctional adhesion molecule C that is encoded in the genome of human.


name: LIAS_HUMAN Lipoyl synthase, mitochondrial (sprot)

description: A lipoyl synthase, mitochondrial that is encoded in the genome of human.


name: GPR17_HUMAN Uracil nucleotide/cysteinyl leukotriene receptor (sprot)

description: A uracil nucleotide/cysteinyl leukotriene receptor that is encoded in the genome of human.


name: CLP1_HUMAN Polyribonucleotide 5'-hydroxyl-kinase Clp1 (sprot)

description: A pre-mRNA cleavage complex II protein Clp1 that is encoded in the genome of human.


name: CML1_HUMAN Chemerin-like receptor 1 (sprot)

description: A chemokine receptor-like protein CMKLR1 that is encoded in the genome of human.


aldehydo-D-glucosamine

The open-chain form of D-glucosamine.


name: ATS17_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 17 (sprot)

description: An a disintegrin and metalloproteinase with thrombospondin motifs 17 that is encoded in the genome of human.


name: SPD2A_HUMAN SH3 and PX domain-containing protein 2A (sprot)

description: An SH3 and PX domain-containing protein 2A that is encoded in the genome of human.


name: ANTR2_HUMAN Anthrax toxin receptor 2 (sprot)

description: An anthrax toxin receptor 2 that is encoded in the genome of human.


FERULATE

A ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 3 and 4 respectively on the phenyl ring.


name: BAD_HUMAN Bcl2-associated agonist of cell death (sprot)

description: A Bcl2-associated agonist of cell death that is encoded in the genome of human.


name: ACKR2_HUMAN Atypical chemokine receptor 2 (sprot)

description: An atypical chemokine receptor 2 that is encoded in the genome of human.


name: TFPI2_HUMAN Tissue factor pathway inhibitor 2 (sprot)

description: A tissue factor pathway inhibitor 2 that is encoded in the genome of human.


name: TF7L2_HUMAN Transcription factor 7-like 2 (sprot)

description: A transcription factor 7-like 2 that is encoded in the genome of human.


FLOT2_HUMAN Flotillin-2 (sprot)

A flotillin-2 that is encoded in the genome of human.


name: HM13_HUMAN Minor histocompatibility antigen H13 (sprot)

description: A minor histocompatibility antigen H13 that is encoded in the genome of human.


name: IMPA3_HUMAN Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (sprot)

description: A Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase that is encoded in the genome of human.


name: MK07_HUMAN Mitogen-activated protein kinase 7 (sprot)

description: A mitogen-activated protein kinase 7 that is encoded in the genome of human.


DPEP1_HUMAN Dipeptidase 1 (sprot)

A dipeptidase 1 that is encoded in the genome of human.


carcinoid syndrome

description: A syndrome characterized by signs and symptoms caused by advanced carcinoid tumors. They include skin flushing, diarrhea, wheezing, and tachycardia.


ITB1_HUMAN Integrin beta-1 (sprot)

An integrin beta-1 that is encoded in the genome of human.


name: RBL2_HUMAN Retinoblastoma-like protein 2 (sprot)

description: A retinoblastoma-like protein 2 that is encoded in the genome of human.


name: ECP_HUMAN Eosinophil cationic protein (sprot)

description: An eosinophil cationic protein that is encoded in the genome of human.


name: RTL1_HUMAN Retrotransposon-like protein 1 (sprot)

description: A retrotransposon-like protein 1 that is encoded in the genome of human.


XLRS1_HUMAN Retinoschisin (sprot)

A retinoschisin that is encoded in the genome of human.


miglustat

A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group.


DELANZOMIB

A C-terminal boronic acid peptide inhibitor which induces apoptosis in multiple myeloma, hematological and solid tumor cell lines.


name: CD1C_HUMAN T-cell surface glycoprotein CD1c (sprot)

description: A T-cell surface glycoprotein CD1c that is encoded in the genome of human.


ethylisopropylamiloride

A member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group.


name: PK2L1_HUMAN Polycystin-2-like protein 1 (sprot)

description: A polycystin-2-like protein 1 that is encoded in the genome of human.


name: PANK3_HUMAN Pantothenate kinase 3 (sprot)

description: A pantothenate kinase 3 that is encoded in the genome of human.


apremilast

A member of the class of isoindoles that is isoindole-1,3-dione substituted at position 4 by an acetamido group and at position 1 by a 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl group. Used for treatment of psoriatic arthritis.


infectious mononucleosis

description: A condition characterized by an increase in mononuclear white blood cells and swollen lymph nodes, which is usually caused by infection with the Epstein-Barr virus.


granulomatous angiitis

description: Inflammation of the arteries that is characterized by the presence of granulomas.


cannabigerol

A member of the class of resorcinols that is resorcinol which is substituted by a (2E)-3,7-dimethylocta-2,6-dien-1-yl group at position 2 and by a pentyl group at position 5. It is a natural product found in Cannabis sativa and Helichrysum species.


cabergoline

An N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substituted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia.


migraine disorder

description: A common, severe type of vascular headache often associated with increased sympathetic activity, resulting in nausea, vomiting, and light sensitivity.


name: NDKA_HUMAN Nucleoside diphosphate kinase A (sprot)

description: A nucleoside diphosphate kinase A that is encoded in the genome of human.


fluoxetine

A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.


name: PIN1_HUMAN Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (sprot)

description: A peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 that is encoded in the genome of human.


name: FGF8_HUMAN Fibroblast growth factor 8 (sprot)

description: A fibroblast growth factor 8 that is encoded in the genome of human.


name: KLF10_HUMAN Krueppel-like factor 10 (sprot)

description: A krueppel-like factor 10 that is encoded in the genome of human.


mycophenolate mofetil

A carboxylic ester resulting from the formal condensation between the carboxylic acid group of mycophenolic acid and the hydroxy group of 2-(morpholin-4-yl)ethanol. In the liver, it is metabolised to mycophenolic acid, an immunosuppressant for which it is a prodrug. It is widely used to prevent tissue rejection following organ transplants as well as for the treatment of certain autoimmune diseases.


name: tubulointerstitial nephritis and uveitis syndrome

description: An autoimmune disorder comprising tubulointerstitial nephritis and uveitis.


DLL4_HUMAN Delta-like protein 4 (sprot)

A delta-like protein 4 that is encoded in the genome of human.


galunisertib

A pyrrolopyrazole that is 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole which is substituted at positions 2 and 3 by 6-methylpyridin-2-yl and 6-(aminocarbonyl)quinolin-4-yl groups, respectively. A Transforming growth factor-betaRI (TGF-betaRI) kinase inhibitor, it blocks TGF-beta-mediated tumor growth in glioblastoma.


name: SPAG8_HUMAN Sperm-associated antigen 8 (sprot)

description: A sperm-associated antigen 8 that is encoded in the genome of human.


MALONALDEHYDE

A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.


MMP3_HUMAN Stromelysin-1 (sprot)

A stromelysin-1 that is encoded in the genome of human.


name: KMT2E_HUMAN Inactive histone-lysine N-methyltransferase 2E (sprot)

description: A histone-lysine N-methyltransferase 2E that is encoded in the genome of human.


sotrastaurin

A member of the class of maleimides that is maleimide which is substituted at position 3 by an indol-3-yl group and at position 4 by a quinazolin-4-yl group, which in turn is substituted at position 2 by a 4-methylpiperazin-1-yl group. It is a potent and selective inhibitor of protein kinase C and has been investigated as an immunosuppresant in renal transplant patients.


name: TTPA_HUMAN Alpha-tocopherol transfer protein (sprot)

description: An alpha-tocopherol transfer protein that is encoded in the genome of human.


name: HSF2_HUMAN Heat shock factor protein 2 (sprot)

description: A heat shock factor protein 2 that is encoded in the genome of human.


name: SOX6_HUMAN Transcription factor SOX-6 (sprot)

description: A transcription factor SOX-6 that is encoded in the genome of human.


name: HECD4_HUMAN Probable E3 ubiquitin-protein ligase HECTD4 (sprot)

description: A probable E3 ubiquitin-protein ligase HECTD4 that is encoded in the genome of human.


A 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine which adopts an R-configuration. It is a potent inhibitor of human EGFR, VEGFR and HER2 receptor tyrosine kinases and exhibits anticancer and antiangiogenic activity.


biliary tract cancer

description: A malignant neoplasm involving the biliary tree


name: RARR2_HUMAN Retinoic acid receptor responder protein 2 (sprot)

description: A retinoic acid receptor responder protein 2 that is encoded in the genome of human.


name: PDE10_HUMAN cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (sprot)

description: A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A that is encoded in the genome of human.


name: HEM1_HUMAN 5-aminolevulinate synthase, non-specific, mitochondrial (sprot)

description: A 5-aminolevulinate synthase, non-specific, mitochondrial that is encoded in the genome of human.


name: TANK_HUMAN TRAF family member-associated NF-kappa-B activator (sprot)

description: A TRAF family member-associated NF-kappa-B activator that is encoded in the genome of human.


fentanyl

A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.


name: S29A2_HUMAN Equilibrative nucleoside transporter 2 (sprot)

description: An equilibrative nucleoside transporter 2 that is encoded in the genome of human.


An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.


name: hematopoietic and lymphoid cell neoplasm

description: A neoplasm arising from hematopoietic cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic system). Hematopoietic cell neoplasms can also involve other anatomic sites (e.g. central nervous system, gastrointestinal tract), either by metastasis, direct tumor infiltration, or neoplastic transformation of extranodal lymphoid tissues. The commonest forms are the various types of leukemia, Hodgkin and non-Hodgkin lymphomas, myeloproliferative neoplasms, and myelodysplastic syndromes.


name: FNBP1_HUMAN Formin-binding protein 1 (sprot)

description: A formin-binding protein 1 that is encoded in the genome of human.


SHIKIMIC ACID

A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid substituted by hydroxy groups at positions 3, 4 and 5 (the 3R,4S,5R stereoisomer). It is an intermediate metabolite in plants and microorganisms.


transient ischemic attack

description: A brief attack (from a few minutes to an hour) of cerebral dysfunction of vascular origin, with no persistent neurological deficit.


Bradycardia

description: A slower than normal heart rate (in adults, slower than 60 beats per minute).


name: ARBK1_HUMAN Beta-adrenergic receptor kinase 1 (sprot)

description: A beta-adrenergic receptor kinase 1 that is encoded in the genome of human.


phosphatidylserine (16:0/18:2)

A phosphatidylserine 34:2 in which the acyl group at C-1 contains 16 carbons and no double bonds while that at C-2 contains 18 carbons and 2 double bonds


name: ACSL5_HUMAN Long-chain-fatty-acid--CoA ligase 5 (sprot)

description: A long-chain-fatty-acid--CoA ligase 5 that is encoded in the genome of human.


Hypoxemia

description: An abnormally low level of blood oxygen.


name: ACER3_HUMAN Alkaline ceramidase 3 (sprot)

description: An alkaline ceramidase 3 that is encoded in the genome of human.


TRFL_HUMAN Lactotransferrin (sprot)

A lactotransferrin that is encoded in the genome of human.


name: BMP6_HUMAN Bone morphogenetic protein 6 (sprot)

description: A bone morphogenetic protein 6 that is encoded in the genome of human.


nelarabine

A purine nucleoside in which O-methylguanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. Inhibits DNA synthesis and causes cell death; a prodrug of 9-beta-D-arabinofuranosylguanine (ara-G).


P2RX7_HUMAN P2X purinoceptor 7 (sprot)

A P2X purinoceptor 7 that is encoded in the genome of human.


name: HS90B_HUMAN Heat shock protein HSP 90-beta (sprot)

description: A heat shock protein HSP 90-beta that is encoded in the genome of human.


riboflavin

D-Ribitol in which the hydroxy group at position 5 is substituted by a 7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl moiety. It is a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables, but the richest natural source is yeast. The free form occurs only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.


name: FGF19_HUMAN Fibroblast growth factor 19 (sprot)

description: A fibroblast growth factor 19 that is encoded in the genome of human.


FBN2_HUMAN Fibrillin-2 (sprot)

A fibrillin-2 that is encoded in the genome of human.


name: TRI16_HUMAN Tripartite motif-containing protein 16 (sprot)

description: A tripartite motif-containing protein 16 that is encoded in the genome of human.


name: HMGB2_HUMAN High mobility group protein B2 (sprot)

description: A high mobility group protein B2 that is encoded in the genome of human.


name: NDF1_HUMAN Neurogenic differentiation factor 1 (sprot)

description: A neurogenic differentiation factor 1 that is encoded in the genome of human.


Hyperkinetic movements

description: Motor hyperactivity with excessive movement of muscles of the body as a whole.


triclosan

An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.


name: KCNQ3_HUMAN Potassium voltage-gated channel subfamily KQT member 3 (sprot)

description: A voltage-gated potassium channel subunit KCNQ3 that is encoded in the genome of human.


talazoparib tosylate

Talazoparib is an orally available small molecule inhibitor of the DNA repair enzyme poly ADP-ribose polymerase (PARP) which is used as an antineoplastic agent in the treatment of selected cases of breast cancer. Talazoparib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury.


fallopian tube carcinoma

description: A carcinoma that arises from epithelial cells of the fallopian tube.


name: RASF7_HUMAN Ras association domain-containing protein 7 (sprot)

description: A Ras association domain-containing protein 7 that is encoded in the genome of human.


LEG7_HUMAN Galectin-7 (sprot)

A galectin-7 that is encoded in the genome of human.


SYNE1_HUMAN Nesprin-1 (sprot)

A nesprin-1 that is encoded in the genome of human.


name: TGM5_HUMAN Protein-glutamine gamma-glutamyltransferase 5 (sprot)

description: A protein-glutamine gamma-glutamyltransferase 5 that is encoded in the genome of human.


name: HCAR2_HUMAN Hydroxycarboxylic acid receptor 2 (sprot)

description: A hydroxycarboxylic acid receptor 2 that is encoded in the genome of human.


name: SGMR1_HUMAN Sigma non-opioid intracellular receptor 1 (sprot)

description: A sigma non-opioid intracellular receptor 1 that is encoded in the genome of human.


ketorolac

A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.


Chandler syndrome

description: Chandler syndrome, the most frequent clinical variant of iridocorneal endothelial (ICE) syndrome, is characterized by very few iris abnormalities but more severe corneal edema and less severe secondary glaucoma than seen in the other two ICE syndrome variants: Cogan-Reese syndrome and essential iris atrophy.


fumaric acid

A butenedioic acid in which the C=C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle.


name: NTR1_HUMAN Neurotensin receptor type 1 (sprot)

description: A neurotensin receptor type 1 that is encoded in the genome of human.


A monoatomic monocation obtained from potassium.


name: CP51A_HUMAN Lanosterol 14-alpha demethylase (sprot)

description: A lanosterol 14-alpha demethylase that is encoded in the genome of human.


name: HPRT_HUMAN Hypoxanthine-guanine phosphoribosyltransferase (sprot)

description: A hypoxanthine-guanine phosphoribosyltransferase that is encoded in the genome of human.


name: HDAC6_HUMAN Histone deacetylase 6 (sprot)

description: A histone deacetylase 6 that is encoded in the genome of human.


disulfiram

An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid.  A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.


APOCYNIN

An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.


SNX1_HUMAN Sorting nexin-1 (sprot)

A sorting nexin-1 that is encoded in the genome of human.


PHORBOL

A diterpenoid with the structure of tigliane hydroxylated at C-4, -9, -12(beta), -13 and -20, with an oxo group at C-3 and unsaturation at the 1- and 6-positions.


name: C163A_HUMAN Scavenger receptor cysteine-rich type 1 protein M130 (sprot)

description: A scavenger receptor cysteine-rich type 1 protein M130 that is encoded in the genome of human.


CUL2_HUMAN Cullin-2 (sprot)

A cullin-2 that is encoded in the genome of human.


RCAN1_HUMAN Calcipressin-1 (sprot)

A calcipressin-1 that is encoded in the genome of human.


The meso-diastereomer of butane-1,2,3,4-tetrol.


name: BAZ2A_HUMAN Bromodomain adjacent to zinc finger domain protein 2A (sprot)

description: A bromodomain adjacent to zinc finger domain protein 2A that is encoded in the genome of human.


name: BAZ2B_HUMAN Bromodomain adjacent to zinc finger domain protein 2B (sprot)

description: A bromodomain adjacent to zinc finger domain protein 2B that is encoded in the genome of human.


Abdominal obesity

description: Excessive fat around the stomach and abdomen.


name: CDC7_HUMAN Cell division cycle 7-related protein kinase (sprot)

description: A cell division cycle 7-related protein kinase that is encoded in the genome of human.


name: VEGFB_HUMAN Vascular endothelial growth factor B (sprot)

description: A vascular endothelial growth factor B that is encoded in the genome of human.


name: STING_HUMAN Stimulator of interferon genes protein (sprot)

description: A transmembrane protein 173 that is encoded in the genome of human.


L-KYNURENINE

A kynurenine that has L configuration.


NPY_HUMAN Pro-neuropeptide Y (sprot)

A neuropeptide Y that is encoded in the genome of human.


AQP9_HUMAN Aquaporin-9 (sprot)

An aquaporin-9 that is encoded in the genome of human.


cefdinir

A cephalosporin compound having 7beta-2-(2-amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino- and 3-vinyl side groups.


name: NR4A1_HUMAN Nuclear receptor subfamily 4immunitygroup A member 1 (sprot)

description: A nuclear receptor subfamily 4 immunity group A member 1 that is encoded in the genome of human.


name: SHBG_HUMAN Sex hormone-binding globulin (sprot)

description: A sex hormone-binding globulin that is encoded in the genome of human.


diphenhydramine

An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.


name: TBX3_HUMAN T-box transcription factor TBX3 (sprot)

description: A T-box transcription factor TBX3 that is encoded in the genome of human.


NEP_HUMAN Neprilysin (sprot)

A neprilysin that is encoded in the genome of human.


MMP13_HUMAN Collagenase 3 (sprot)

A collagenase 3 that is encoded in the genome of human.


MMP10_HUMAN Stromelysin-2 (sprot)

A stromelysin-2 that is encoded in the genome of human.


name: PTPRJ_HUMAN Receptor-type tyrosine-protein phosphatase eta (sprot)

description: A receptor-type tyrosine-protein phosphatase eta that is encoded in the genome of human.


name: LDB2_HUMAN LIM domain-binding protein 2 (sprot)

description: A LIM domain-binding protein 2 that is encoded in the genome of human.


tyramine

A primary amino compound obtained by formal decarboxylation of the amino acid tyrosine.


Hypertensive crisis

description: A severe, acute increase in blood pressure that may result in stroke or myocardial ischemia.


MAP7_HUMAN Ensconsin (sprot)

An ensconsin that is encoded in the genome of human.


name: S4A4_HUMAN Electrogenic sodium bicarbonate cotransporter 1 (sprot)

description: An electrogenic sodium bicarbonate cotransporter 1 that is encoded in the genome of human.


phencyclidine

A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group.  Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.


name: hypertelorism-preauricular sinus-punctual pits-deafness syndrome


name: LIRB1_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 1 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily B member 1 that is encoded in the genome of human.


mantle cell lymphoma

description: Mantle cell lymphoma is a rare form of malignant non-Hodgkin lymphoma affecting B lymphocytes in the lymph nodes in a region called the ``mantle zone''.


salvianolic acid B

A member of the class of 1-benzofurans that is an antioxidant and free radical scavenging compound extracted from S. miltiorrhiza


A member of the class of pyrrolecarboxamides obtained by formal condensation of the carboxy group of 5-[(Z)-(5-chloro-2-oxo-1,2-dihydroindol-3-ylidene)methyl]-2,4-dimethylpyrrole-3-carboxylic acid with the primary amino group of N(1),N(1)-diethylethane-1,2-diamine.


olanzapine

A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.


name: HMCS2_HUMAN Hydroxymethylglutaryl-CoA synthase, mitochondrial (sprot)

description: A hydroxymethylglutaryl-CoA synthase, mitochondrial that is encoded in the genome of human.


name: PGAM1_HUMAN Phosphoglycerate mutase 1 (sprot)

description: A phosphoglycerate mutase 1 that is encoded in the genome of human.


flubendazole

A member of the class of mebendazole in which the benzoyl group is replaced by a p-fluorobenzoyl group. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections.


ammonium chloride

An inorganic chloride having ammonium as the counterion.


name: LTBP1_HUMAN Latent-transforming growth factor beta-binding protein 1 (sprot)

description: A latent TGF-beta-binding protein 1 that is encoded in the genome of human.


name: ESM1_HUMAN Endothelial cell-specific molecule 1 (sprot)

description: An endothelial cell-specific molecule 1 that is encoded in the genome of human.


name: PACR_HUMAN Pituitary adenylate cyclase-activating polypeptide type I receptor (sprot)

description: A pituitary adenylate cyclase-activating polypeptide type I receptor that is encoded in the genome of human.


name: MTA1_HUMAN Metastasis-associated protein MTA1 (sprot)

description: A metastasis-associated protein MTA1 that is encoded in the genome of human.


name: PROX1_HUMAN Prospero homeobox protein 1 (sprot)

description: A prospero homeobox protein 1 that is encoded in the genome of human.


name: HNF4A_HUMAN Hepatocyte nuclear factor 4-alpha (sprot)

description: A hepatocyte nuclear factor 4-alpha that is encoded in the genome of human.


CCNI_HUMAN Cyclin-I (sprot)

A cyclin-I that is encoded in the genome of human.


name: NR1I3_HUMAN Nuclear receptor subfamily 1 group I member 3 (sprot)

description: A nuclear receptor subfamily 1 group I member 3 that is encoded in the genome of human.


vilazodone

A 1-benzofuran that is 5-(piperazin-1-yl}-1-benzofuran-2-carboxamide having a (5-cyanoindol-3-yl)butyl group attached at position N-4 on the piperazine ring. Used for the treatment of major depressive disorder.


name: FACE1_HUMAN CAAX prenyl protease 1 homolog (sprot)

description: A CAAX prenyl protease 1 that is encoded in the genome of human.


BETA-NAPHTHOFLAVONE

An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.


name: TNR1A_HUMAN Tumor necrosis factor receptor superfamily member 1A (sprot)

description: A tumor necrosis factor receptor superfamily member 1A that is encoded in the genome of human.


name: SC5A2_HUMAN Sodium/glucose cotransporter 2 (sprot)

description: A sodium/glucose cotransporter 2 that is encoded in the genome of human.


DLL1_HUMAN Delta-like protein 1 (sprot)

A delta-like protein 1 that is encoded in the genome of human.


NUCL_HUMAN Nucleolin (sprot)

A nucleolin that is encoded in the genome of human.


name: AKT1_HUMAN RAC-alpha serine/threonine-protein kinase (sprot)

description: A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of human.


name: PTHR_HUMAN Parathyroid hormone-related protein (sprot)

description: A parathyroid hormone-related protein that is encoded in the genome of human.


penile cancer

description: A primary or metastatic malignant neoplasm that affects the penis. Representative examples include penile carcinoma and penile sarcoma.


phosphatidylcholine (P-40:3)

A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the unspecified alk-1-enyl and acyl groups at positions 1 and 2 contain 40 carbon atoms in total with 3 additional double bonds in the acyl moiety.


PRDX6_HUMAN Peroxiredoxin-6 (sprot)

A peroxiredoxin-6 that is encoded in the genome of human.


breast carcinoma

description: A carcinoma that arises from epithelial cells of the breast


oxamide

A dicarboxylic acid diamide of oxalic acid.


name: KLC4_HUMAN Kinesin light chain 4 (sprot)

description: A kinesin light chain 4 that is encoded in the genome of human.


name: SETD3_HUMAN Actin-histidine N-methyltransferase (sprot)

description: An actin-histidine N-methyltransferase that is encoded in the genome of human.


name: KCNJ3_HUMAN G protein-activated inward rectifier potassium channel 1 (sprot)

description: A G protein-activated inward rectifier potassium channel 1 that is encoded in the genome of human.


name: RAG1_HUMAN V(D)J recombination-activating protein 1 (sprot)

description: A V(D)J recombination-activating protein 1 that is encoded in the genome of human.


name: MPDZ_HUMAN Multiple PDZ domain protein (sprot)

description: A multiple PDZ domain protein that is encoded in the genome of human.


name: GIT1_HUMAN ARF GTPase-activating protein GIT1 (sprot)

description: An ARF GTPase-activating protein GIT1 that is encoded in the genome of human.


name: GPD1L_HUMAN Glycerol-3-phosphate dehydrogenase 1-like protein (sprot)

description: A glycerol-3-phosphate dehydrogenase 1-like protein that is encoded in the genome of human.


SODIUM ASCORBATE

An organic sodium salt resulting from the replacement of the proton from the 3-hydroxy group of ascorbic acid by a sodium ion.


JASMONIC ACID

An oxo monocarboxylic acid that is (3-oxocyclopentyl)acetic acid substituted by a (2Z)-pent-2-en-1-yl group at position 2 of the cyclopentane ring.


SPB6_HUMAN Serpin B6 (sprot)

A serpin B6 that is encoded in the genome of human.


name: NFIL3_HUMAN Nuclear factor interleukin-3-regulated protein (sprot)

description: A nuclear factor interleukin-3-regulated protein that is encoded in the genome of human.


name: ANTR1_HUMAN Anthrax toxin receptor 1 (sprot)

description: An anthrax toxin receptor 1 that is encoded in the genome of human.


name: RM23_HUMAN Large ribosomal subunit protein uL23m (sprot)

description: A large ribosomal subunit protein uL23m that is encoded in the genome of human.


name: RS7_HUMAN Small ribosomal subunit protein eS7 (sprot)

description: A small ribosomal subunit protein eS7 that is encoded in the genome of human.


malignant epithelioid mesothelioma

description: A malignant neoplasm arising from mesothelial cells in the pleura. It is characterized by the presence of neoplastic cells with an epithelioid appearance. In the majority of cases, the neoplastic epithelioid cells lack significant cytologic atypia; mitotic figures are infrequently seen. In a minority of cases, the neoplastic cells are poorly differentiated and there is evidence of nuclear atypia and increased mitotic activity.


name: ATF4_HUMAN Cyclic AMP-dependent transcription factor ATF-4 (sprot)

description: A cyclic AMP-dependent transcription factor ATF-4 that is encoded in the genome of human.


name: RHDF2_HUMAN Inactive rhomboid protein 2 (sprot)

description: An inactive rhomboid protein 2 that is encoded in the genome of human.


name: TERF1_HUMAN Telomeric repeat-binding factor 1 (sprot)

description: A telomeric repeat-binding factor 1 that is encoded in the genome of human.


name: SMYD2_HUMAN N-lysine methyltransferase SMYD2 (sprot)

description: An N-lysine methyltransferase SMYD2 that is encoded in the genome of human.


A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway.


pulmonary edema

description: Accumulation of fluid in the lung tissues causing disturbance of the gas exchange that may lead to respiratory failure. It is caused by direct injury to the lung parenchyma or congestive heart failure. The symptoms may appear suddenly or gradually. Suddenly appearing symptoms include difficulty breathing, feeling of suffocation, and coughing associated with frothy sputum. Gradually appearing symptoms include difficulty breathing while lying in bed, shortness of breath during activity, and weight gain (in patients with congestive heart failure).


name: PAAF1_HUMAN Proteasomal ATPase-associated factor 1 (sprot)

description: A proteasomal ATPase-associated factor 1 that is encoded in the genome of human.


aseptic meningitis

description: Inflammation of the membranes surrounding the brain and spinal cord without a bacterial pathogen.


sodium chlorite

An inorganic sodium salt in which chlorite is the counterion.


low tension glaucoma

description: A form of glaucoma in which chronic optic nerve damage and loss of vision normally attributable to buildup of intraocular pressure occurs despite prevailing conditions of normal intraocular pressure.


acute lymphoblastic leukemia

description: Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia.


description: T-cell large granular lymphocyte leukemia (T-cell LGL leukemia) is a lymphoproliferative malignancy that arises from the mature T-cell (CD3+) lineage.


name: EF2K_HUMAN Eukaryotic elongation factor 2 kinase (sprot)

description: An elongation factor 2 kinase that is encoded in the genome of human.


prostate intraepithelial neoplasia

description: A neoplastic proliferation of the epithelial cells that line the acini and the ducts of the prostate gland. The neoplastic epithelial cells are confined within the acini and the ducts and they do not invade the surrounding prostatic stroma. Morphologically, it is classified as low or high grade.


name: KCC1G_HUMAN Calcium/calmodulin-dependent protein kinase type 1G (sprot)

description: A calcium/calmodulin-dependent protein kinase type 1G that is encoded in the genome of human.


name: AGGF1_HUMAN Angiogenic factor with G patch and FHA domains 1 (sprot)

description: An angiogenic factor with G patch and FHA domains 1 that is encoded in the genome of human.


name: THBG_HUMAN Thyroxine-binding globulin (sprot)

description: A thyroxine-binding globulin that is encoded in the genome of human.


name: PAF15_HUMAN PCNA-associated factor (sprot)

description: A PCNA-associated factor that is encoded in the genome of human.


tenofovir

A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.


name: CXCL3_HUMAN C-X-C motif chemokine 3 (sprot)

description: A C-X-C motif chemokine 3 that is encoded in the genome of human.


APOA5_HUMAN Apolipoprotein A-V (sprot)

An apolipoprotein A-V that is encoded in the genome of human.


name: maturity-onset diabetes of the young type 1

description: Monogenic diabetes caused by inactivating mutation(s) in the gene HNF4A, encoding hepatocyte nuclear factor 4-alpha.


PKD1_HUMAN Polycystin-1 (sprot)

A polycystin-1 that is encoded in the genome of human.


name: attention deficit hyperactivity disorder, inattentive type

description: A mental disorder characterized by inattention, easy distraction, careless mistakes and avoidance of tasks that require sustained mental focus. These behaviors can lead to maladaptive consequences in the affected individual's life.


Accelerated atherosclerosis

description: Atherosclerosis which occurs in a person with certain risk factors (e.g., SLE, diabetes, smoking, hypertension, hypercholesterolaemia, family history of early heart disease) at an earlier age than would occur in another person without those risk factors.


name: CNTF_HUMAN Ciliary neurotrophic factor (sprot)

description: A ciliary neurotrophic factor that is encoded in the genome of human.


quinine

A cinchona alkaloid that is cinchonidine in which the hydrogen at the 6-position of the quinoline ring is substituted by methoxy.


nitroglycerin

A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.


ventricular septal defect

description: The presence of a defect (opening) in the septum that separates the two ventricles of the heart. It can be congenital or acquired.


name: METK2_HUMAN S-adenosylmethionine synthase isoform type-2 (sprot)

description: An S-adenosylmethionine synthetase isoform type-2 that is encoded in the genome of human.


TMOD3_HUMAN Tropomodulin-3 (sprot)

A tropomodulin-3 that is encoded in the genome of human.


bacterial pneumonia

description: Acute infection of the lung parenchyma caused by bacteria (e.g., Streptococcus pneumoniae, Haemophilus influenzae, Chlamydia pneumoniae, Mycoplasma pneumoniae, and Legionella pneumophila). Signs and symptoms include productive cough, fever, chills, shortness of breath, and chest pain.


name: TNIP2_HUMAN TNFAIP3-interacting protein 2 (sprot)

description: A TNFAIP3-interacting protein 2 that is encoded in the genome of human.


name: M3K8_HUMAN Mitogen-activated protein kinase kinase kinase 8 (sprot)

description: A mitogen-activated protein kinase kinase kinase 8 that is encoded in the genome of human.


hypoxanthine

A purine nucleobase that consists of purine bearing an oxo substituent at position 6.


name: autoimmune pulmonary alveolar proteinosis

description: Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by the accumulation of a lipoproteinaceous substance in the distal air spaces which positively stains with periodic acid-Schiff (PAS).


Dravet syndrome

description: Dravet syndrome is a channelopathy with epilepsy of with onset during the first year of life, typically 4-5 months, characterized by status epilepticus and a variety of drug-resistant seizures often induced by fever, presenting in previously healthy children, and which frequently leads to cognitive and motor impairment. Dravet differs from other channelopathies usually due to a mutation in SCN1A.


name: CBL_HUMAN E3 ubiquitin-protein ligase CBL (sprot)

description: An E3 ubiquitin-protein ligase CBL that is encoded in the genome of human.


VAV_HUMAN Proto-oncogene vav (sprot)

A proto-oncogene vav that is encoded in the genome of human.


palmitoleic acid

A hexadec-9-enoic acid in which the double bond at position C-9 has cis configuration.


baclofen

An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of baclofen.


name: LGR4_HUMAN Leucine-rich repeat-containing G-protein coupled receptor 4 (sprot)

description: A leucine-rich repeat-containing G-protein coupled receptor 4 that is encoded in the genome of human.


A organic heterotricyclic compound that is 5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indole substituted at position 6 by a 1-naphthylcarbonyl group.


focal epilepsy

description: A seizure caused by a localized disorder.


name: PDZD2_HUMAN PDZ domain-containing protein 2 (sprot)

description: A PDZ domain-containing protein 2 that is encoded in the genome of human.


xeroderma pigmentosum

description: Xeroderma pigmentosum (XP) is a rare genodermatosis characterized by extreme sensitivity to ultraviolet (UV)-induced changes in the skin and eyes, and multiple skin cancers. It is subdivided into 8 complementation groups, according to the affected gene: classical XP (XPA to XPG) and XP variant (XPV).


periodontal disorder

description: An inflammatory process of the gingival tissues and/or periodontal membrane of the teeth, resulting in an abnormally deep gingival sulcus, possibly producing periodontal pockets and loss of alveolar bone support.


name: CHSTF_HUMAN Carbohydrate sulfotransferase 15 (sprot)

description: A carbohydrate sulfotransferase 15 that is encoded in the genome of human.


clenbuterol

A substituted aniline that is 2,6-dichloroaniline in which the hydrogen at position 4 has been replaced by a 2-(tert-butylamino)-1-hydroxyethyl group.


name: AT1A3_HUMAN Sodium/potassium-transporting ATPase subunit alpha-3 (sprot)

description: A sodium/potassium-transporting ATPase subunit alpha-3 that is encoded in the genome of human.


dextromethorphan

A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.


childhood leukemia

description: An acute or chronic leukemia that occurs during childhood.


palonosetron

An organic heterotricyclic compound that is an antiemetic used (as its hydrochloride salt) in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.


name: RAP1B_HUMAN Ras-related protein Rap-1b (sprot)

description: A Ras-related protein Rap-1b that is encoded in the genome of human.


prostate disorder

description: A disease involving the prostate gland.


aortic valve stenosis

description: Aortic valve stenosis (AVS) is a condition characterized by narrowing of the heart's aortic valve opening. This narrowing prevents the valve from opening fully, which obstructs blood flow from the heart into the aorta, and onward to the rest of the body. AVS can range from mild to severe. Signs and symptoms typically develop when the narrowing of the opening is severe and may include chest pain (angina) or tightness; shortness of breath or fatigue (especially during exertion); feeling faint or fainting; heart palpitations; and heart murmur. Individuals with less severe congenital AVS (present at birth) may not develop symptoms until adulthood. Individuals with severe cases may faint without warning. AVS can have several causes including abnormal development before birth (such as having 1 or 2 valve leaflets instead of 3); calcium build-up on the valve in adulthood; and rheumatic fever.


WNT9B_HUMAN Protein Wnt-9b (sprot)

A protein Wnt-9b that is encoded in the genome of human.


sphingosine

A sphing-4-enine in which the double bond is trans.


retinitis pigmentosa

description: Retinitis pigmentosa (RP) is an inherited retinal dystrophy leading to progressive loss of the photoreceptors and retinal pigment epithelium and resulting in blindness usually after several decades.


CATECHIN GALLATE

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3S)-hydroxy group of (+)-catechin.


quinidine

A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.


L-proline

Pyrrolidine in which the pro-S hydrogen at position 2 is substituted by a carboxylic acid group. L-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group alpha to the carboxyl group. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles.


name: PK3CG_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (sprot)

description: A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform that is encoded in the genome of human.


name: MED23_HUMAN Mediator of RNA polymerase II transcription subunit 23 (sprot)

description: A mediator of RNA polymerase II transcription subunit 23 that is encoded in the genome of human.


salsalate

A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes.


SARCO_HUMAN Sarcolipin (sprot)

A sarcolipin that is encoded in the genome of human.


giant cell tumor

description: A benign, intermediate, or malignant tumor that arises from the bone or soft tissue. It is characterized by the presence of multinucleated osteoclast-like giant cells.


name: CHK2_HUMAN Serine/threonine-protein kinase Chk2 (sprot)

description: A serine/threonine-protein kinase Chk2 that is encoded in the genome of human.


cefuroxime

A 3-(carbamoyloxymethyl)cephalosporin compound having a 7-(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido side chain.


TLR5_HUMAN Toll-like receptor 5 (sprot)

A Toll-like receptor 5 that is encoded in the genome of human.


RGN_HUMAN Regucalcin (sprot)

A regucalcin that is encoded in the genome of human.


malignant pleural mesothelioma

description: A malignant neoplasm that arises from mesothelial cells in the pleura and shows a diffuse growth pattern. It arises on the parietal and sometimes visceral pleura as multiple small nodules that later become confluent and invade the chest wall adipose tissue and muscle. Asbestos exposure is the main cause for the development of pleural malignant mesothelioma. It usually affects patients over sixty years of age. The latency period is long. Patients usually present with pleural effusion, dyspnea and chest wall pain. Additional signs and symptoms include chills, sweating, weight loss, and weakness. Morphologic variants include epithelioid, desmoplastic, sarcomatoid, and biphasic mesothelioma. The clinical course is usually aggressive.


name: UBC9_HUMAN SUMO-conjugating enzyme UBC9 (sprot)

description: A SUMO-conjugating enzyme UBC9 that is encoded in the genome of human.


name: GPR39_HUMAN G-protein coupled receptor 39 (sprot)

description: A G-protein coupled receptor 39 that is encoded in the genome of human.


ATX3_HUMAN Ataxin-3 (sprot)

An ataxin-3 that is encoded in the genome of human.


FBX6_HUMAN F-box only protein 6 (sprot)

An F-box only protein 6 that is encoded in the genome of human.


name: MBD2_HUMAN Methyl-CpG-binding domain protein 2 (sprot)

description: A methyl-CpG-binding domain protein 2 that is encoded in the genome of human.


name: CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A (sprot)

description: A voltage-dependent P/Q-type calcium channel subunit alpha-1A that is encoded in the genome of human.


VDR_HUMAN Vitamin D3 receptor (sprot)

A vitamin D3 receptor that is encoded in the genome of human.


stearic acid

A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and  plastics.


name: CCL20_HUMAN C-C motif chemokine 20 (sprot)

description: A C-C motif chemokine 20 that is encoded in the genome of human.


ACTH

A polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency.


oleanolic acid

A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.


fisetin

A 7-hydroxyflavonol with additional hydroxy groups at positions 3, 3' and 4'.


amyloidosis

description: A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.


acute asthma

description: An asthma that is characterized by severe and sudden onset of increasing wheezing, airways closing, smooth muscle contraction, mucus plugging and lower airway edema that may be reversible upon treatment.


crescentic glomerulonephritis

description: A histopathologic term for a pattern of diseases characterized by extensive crescent formation in the glomeruli; patients present clinically with rapid deterioration of renal function, and possible progression to end-stage renal failure within weeks or months.


Hematuria

description: The presence of blood in the urine. Hematuria may be gross hematuria (visible to the naked eye) or microscopic hematuria (detected by dipstick or microscopic examination of the urine).


phosphatidylcholine (P-16:0/18:1)

A phosphatidylcholine P-34:1 in which the 1-alk-1-enyl group contains 16 carbons and no additional double bonds while the 2-acyl group contains 18 carbons and 1 double bond.


ticagrelor

A triazolopyrimidine that is an adenosine isostere; the cyclopentane ring is similar to ribose and the nitrogen-rich [1,2,3]triazolo[4,5-d]pyrimidine moiety resembles the nucleobase adenine. A platelet aggregation inhibitor which is used for prevention of thromboembolic events in patients with acute coronary syndrome.


fetal growth restriction

description: A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age.


name: CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H (sprot)

description: A voltage-dependent T-type calcium channel subunit alpha-1H that is encoded in the genome of human.


gram-negative bacterial infections

description: Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.


name: NAA50_HUMAN N-alpha-acetyltransferase 50 (sprot)

description: An N-alpha-acetyltransferase 50 that is encoded in the genome of human.


Plasmodium ovale malaria

description: An malaria caused by infection with Plasmodium ovale.


name: PLK1_HUMAN Serine/threonine-protein kinase PLK1 (sprot)

description: A serine/threonine-protein kinase PLK1 that is encoded in the genome of human.


name: MCM4_HUMAN DNA replication licensing factor MCM4 (sprot)

description: A DNA replication licensing factor MCM4 that is encoded in the genome of human.


coronary atherosclerosis

description: Atherosclerosis of the coronary vasculature.


naltrexone

An  organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group. A mu-opioid receptor antagonist, it is used to treat alcohol dependence.


belinostat

A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.


name: PDC6I_HUMAN Programmed cell death 6-interacting protein (sprot)

description: A programmed cell death 6-interacting protein that is encoded in the genome of human.


name: GRM5_HUMAN Metabotropic glutamate receptor 5 (sprot)

description: A metabotropic glutamate receptor 5 that is encoded in the genome of human.


congenital heart disease

description: A heart disease that is present at birth. Representative examples include atrial septal defect, ventricular septal defect, tetralogy of Fallot, and patent foramen ovale.


propylthiouracil

A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.


name: DOT1L_HUMAN Histone-lysine N-methyltransferase, H3 lysine-79 specific (sprot)

description: A histone-lysine N-methyltransferase, H3 lysine-79 specific that is encoded in the genome of human.


FLUVASTATIN

A dihydroxy monocarboxylic acid that is N-isopropylindole which is substituted at position 3 by a p-fluorophenyl group and at position 2 by a 6-carboxy-3,5-dihydroxyhex-1-en-1-yl group. It has four possible diastereoisomers.


cervical intraepithelial neoplasia

description: Squamous or glandular intraepithelial neoplasia that affects the cervical mucosal epithelium. There is no evidence of stromal invasion. According to the degree of cellular atypia and the associated architectural changes, it is classified as low or high grade.


name: PROC_HUMAN Vitamin K-dependent protein C (sprot)

description: A vitamin K-dependent protein C that is encoded in the genome of human.


name: MRC1_HUMAN Macrophage mannose receptor 1 (sprot)

description: A macrophage mannose receptor 1 that is encoded in the genome of human.


name: TRYB1_HUMAN Tryptase alpha/beta-1 (sprot)

description: A tryptase alpha/beta-1 that is encoded in the genome of human.


name: SMC1A_HUMAN Structural maintenance of chromosomes protein 1A (sprot)

description: A structural maintenance of chromosomes protein 1A that is encoded in the genome of human.


chlorprothixene

A chlorprothixene in which the double bond adopts a (Z)-configuration.


calcifediol

A hydroxycalciol that is calciol in which the hydrogen at position 25 has been replaced by a hydroxy group. A prehormone resulting from the oxidation of calciol in the liver, it is further hydroxylated in the kidney to give calcitriol, the active form of vitamin D3.


name: FGF23_HUMAN Fibroblast growth factor 23 (sprot)

description: A fibroblast growth factor 23 that is encoded in the genome of human.


CP1A2_HUMAN Cytochrome P450 1A2 (sprot)

A cytochrome P450 1A2 that is encoded in the genome of human.


name: PLAL2_HUMAN Zinc finger protein PLAGL2 (sprot)

description: A zinc finger protein PLAGL2 that is encoded in the genome of human.


name: NSD2_HUMAN Histone-lysine N-methyltransferase NSD2 (sprot)

description: A histone-lysine N-methyltransferase NSD2 that is encoded in the genome of human.


name: AA1R_HUMAN Adenosine receptor A1 (sprot)

description: An adenosine receptor A1 that is encoded in the genome of human.


name: SPN90_HUMAN NCK-interacting protein with SH3 domain (sprot)

description: A NCK-interacting protein with SH3 domain that is encoded in the genome of human.


name: EPHA3_HUMAN Ephrin type-A receptor 3 (sprot)

description: An ephrin type-A receptor 3 that is encoded in the genome of human.


epithelioid sarcoma

description: An aggressive malignant neoplasm of uncertain differentiation, characterized by the presence of epithelioid cells forming nodular patterns. The nodules often undergo central necrosis, resulting in a pseudogranulomatous growth pattern. It usually occurs in young adults. The most common sites of involvement are the extremities (distal-type epithelioid sarcoma), and less frequently the pelvis, perineum, and genital organs (proximal-type epithelioid sarcoma).


niraparib

A 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy.


name: KLF9_HUMAN Krueppel-like factor 9 (sprot)

description: A krueppel-like factor 9 that is encoded in the genome of human.


name: SPIT1_HUMAN Kunitz-type protease inhibitor 1 (sprot)

description: A Kunitz-type protease inhibitor 1 that is encoded in the genome of human.


recessive X-linked ichthyosis

description: A genodermatosis belonging to the Mendelian Disorders of Cornification (MeDOC) and characterized by generalized hyperkeratosis and scaling of the skin.


aminoguanidine

A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.


name: KMT5B_HUMAN Histone-lysine N-methyltransferase KMT5B (sprot)

description: A histone-lysine N-methyltransferase KMT5B that is encoded in the genome of human.


digitoxin

A cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain.


name: PPBI_HUMAN Intestinal-type alkaline phosphatase (sprot)

description: An intestinal alkaline phosphatase that is encoded in the genome of human.


name: ERR3_HUMAN Estrogen-related receptor gamma (sprot)

description: An estrogen-related receptor gamma that is encoded in the genome of human.


name: UCP1_HUMAN Mitochondrial brown fat uncoupling protein 1 (sprot)

description: A mitochondrial brown fat uncoupling protein 1 that is encoded in the genome of human.


name: SERC5_HUMAN Serine incorporator 5 (sprot)

description: A serine incorporator 5 that is encoded in the genome of human.


milrinone

A member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure.


myocarditis

description: Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus, Wegener's granulomatosis, giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and rarely, a heart transplant may be needed if the heart muscle becomes weak.


name: FLT3_HUMAN Receptor-type tyrosine-protein kinase FLT3 (sprot)

description: A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of human.


migraine with aura

description: A migraine disorder characterized by episodes that are preceded by focal neurological symptoms.


name: KCNB1_HUMAN Potassium voltage-gated channel subfamily B member 1 (sprot)

description: A voltage-gated potassium channel KCNB1 that is encoded in the genome of human.


exanthem

description: Any change in the skin which affects its appearance or texture. A rash may be localized to one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful.


name: PRGC1_HUMAN Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (sprot)

description: A peroxisome proliferator-activated receptor gamma coactivator 1-alpha that is encoded in the genome of human.


name: CRIS3_HUMAN Cysteine-rich secretory protein 3 (sprot)

description: A cysteine-rich secretory protein 3 that is encoded in the genome of human.


name: SMCA5_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (sprot)

description: A SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 that is encoded in the genome of human.


name: EDF1_HUMAN Endothelial differentiation-related factor 1 (sprot)

description: An endothelial differentiation-related factor 1 that is encoded in the genome of human.


name: GGYF2_HUMAN GRB10-interacting GYF protein 2 (sprot)

description: A GRB10-interacting GYF protein 2 that is encoded in the genome of human.


(-)-Epicatechin

A catechin with (2R,3R)-configuration.


MYF5_HUMAN Myogenic factor 5 (sprot)

A myogenic factor 5 that is encoded in the genome of human.


brain injury

description: Acute and chronic (see also brain INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and brain STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.


name: ATIF1_HUMAN ATPase inhibitor, mitochondrial (sprot)

description: An ATPase inhibitor, mitochondrial that is encoded in the genome of human.


name: STK11_HUMAN Serine/threonine-protein kinase STK11 (sprot)

description: A serine/threonine-protein kinase STK11 that is encoded in the genome of human.


ZINGERONE

A methyl ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at positions 3 and 4 by methoxy and hydroxy groups respectively. The major pungent component in ginger.


benign prostatic hyperplasia

description: A non-cancerous nodular enlargement of the prostate gland. It is characterized by the presence of epithelial cell nodules, and stromal nodules containing fibrous and smooth muscle elements. It is the most common urologic disorder in men, causing blockage of urine flow.


robenacoxib

An aromatic amino acid that is 2-amino-5-ethylphenylacetic acid in which one of the amino hydrogens is replaced by a 2,3,5,6-tetrafluorophenyl group. A selective cyclooxygenase 2 inhibitor that is used in veterinary medicine for the relief of pain and inflammation in cats and dogs.


SULFURIC ACID

A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom.


huperzine A

A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.


name: ASXL2_HUMAN Putative Polycomb group protein ASXL2 (sprot)

description: A putative Polycomb group protein ASXL2 that is encoded in the genome of human.


CALB2_HUMAN Calretinin (sprot)

A calretinin that is encoded in the genome of human.


DACH1_HUMAN Dachshund homolog 1 (sprot)

A dachshund homolog 1 that is encoded in the genome of human.


hepatitis E virus infection

description: Acute inflammation of the liver in humans; caused by hepatitis E virus, a non-enveloped single-stranded rna virus. Similar to hepatitis A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission.


TRY1_HUMAN Serine protease 1 (sprot)

A serine protease 1 that is encoded in the genome of human.


AXIN2_HUMAN Axin-2 (sprot)

An Axin-2 that is encoded in the genome of human.


name: TPPP3_HUMAN Tubulin polymerization-promoting protein family member 3 (sprot)

description: A tubulin polymerization-promoting protein family member 3 that is encoded in the genome of human.


postherpetic neuralgia

description: Pain that occurs after the disappearance of herpes zoster infection lesions.


mianserin

A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.


restless legs syndrome

description: A condition that occurs while resting or lying in bed; it is characterized by an irresistible urgency to move the legs to obtain relief from a strange and uncomfortable sensation in the legs.


benzocaine

A benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina.


bicalutamide

A member of the class of (trifluoromethyl)benzenes that is 4-amino-2-(trifluoromethyl)benzonitrile in which one of the amino hydrogens is substituted by a 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoyl group.


MFN2_HUMAN Mitofusin-2 (sprot)

A mitofusin-2 that is encoded in the genome of human.


name: CLC1B_HUMAN C-type lectin domain family 1 member B (sprot)

description: A C-type lectin domain family 1 member B that is encoded in the genome of human.


name: STAT1_HUMAN Signal transducer and activator of transcription 1-alpha/beta (sprot)

description: A signal transducer and activator of transcription 1 that is encoded in the genome of human.


Pituitary macroadenoma

description: A pituitary gland adenoma that is larger than 10mm.


name: IRX6_HUMAN Iroquois-class homeodomain protein IRX-6 (sprot)

description: An iroquois-class homeodomain protein IRX-6 that is encoded in the genome of human.


name: SNAI3_HUMAN Zinc finger protein SNAI3 (sprot)

description: A zinc finger protein SNAI3 that is encoded in the genome of human.


NK cell deficiency

description: A primary immunodeficiency disease that results from defeciency in the number or function of CD56+CD3− NK cell in peripheral blood.


name: KCND3_HUMAN Potassium voltage-gated channel subfamily D member 3 (sprot)

description: A voltage-gated potassium channel KCND3 that is encoded in the genome of human.


name: MSI1H_HUMAN RNA-binding protein Musashi homolog 1 (sprot)

description: An RNA-binding protein Musashi homolog 1 that is encoded in the genome of human.


name: 2AAA_HUMAN Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (sprot)

description: A serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform that is encoded in the genome of human.


name: 2ABG_HUMAN Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (sprot)

description: A serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform that is encoded in the genome of human.


aminoglutethimide

A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.


phosphatidylcholine (18:0/22:5)

A 1,2-diacyl-sn-glycero-3-phosphocholine in which one acyl group has 18 carbons and is fully saturated while the other has 22 carbons and 5 double bonds.


name: DCE2_HUMAN Glutamate decarboxylase 2 (sprot)

description: A glutamate decarboxylase 2 that is encoded in the genome of human.


bentonite

An aluminosilicate mineral consisting mostly of montmorillonite. The different types of bentonite (aluminium bentonite; calcium bentonite; potassium bentonite; sodium bentonite) are named after their dominant element.


pyrvinium

A quinolinium ion that is 1-methylquinolinium substituted by dimethylamino group at position 6 and a (E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl at position 2. It is a  anthelminthic drug active against pinworms. The salts of pyrvinium can also be used as anticancer agents.