lixisenatide

A forty-four membered polypeptide consisting of L-His, Gly, L-Glu, Gly, L-Thr, L-Phe, L-Thr, L-Ser, L-Asp, L-Leu, L-Ser, L-Lys, L-Gln, L-Met, L-Glu, L-Glu, L-Glu, L-Ala, L-Val, L-Arg, L-Leu, L-Phe, L-Ile, L-Glu, L-Trp, L-Leu, L-Lys, L-Asn, Gly, Gly, LPro, L-Ser, L-Ser, Gly, L-Ala, L-Pro, L-Pro, L-Ser, L-Lys, L-Lys, L-Lys, L-Lys, L-Lys, and L-Lys-NH2 residues joined in sequence. Used as an adjunct to diet and exercise for the treatment of adults with type II diabetes.


cytokine release syndrome

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A syndrome that occurs after therapeutic infusion of antibodies into the blood and is characterized by nausea, headache, tachycardia, hypotension, rash, and shortness of breath. It is caused by the release of cytokines from the cells that are targeted by the antibodies. Most patients experience a mild to moderate reaction; however, the reaction may be severe and life-threatening.


phosphatidylcholine (16:0/18:3)

A phosphatidylcholine 34:3 in which the fatty acyl groups at positions 1 and 2 are specified as C16:0 and C18:3 respectively.


nadolol

Nadolol is a diastereoisomeric mixture consisting of equimolar amounts of the four possible 2,3-cis-isomers of 5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol.


cardiac conduction defect

description: The heart suddenly and unexpectedly stops beating resulting in death within a short time period (generally within 1 h of symptom onset).


name: EGR3_HUMAN Early growth response protein 3 (sprot)

description: An early growth response protein 3 that is encoded in the genome of human.


UTS2_HUMAN Urotensin-2 (sprot)

A urotensin-2 that is encoded in the genome of human.


CCN5_HUMAN CCN family member 5 (sprot)

A CCN family member 5 that is encoded in the genome of human.


name: PBOV1_HUMAN Prostate and breast cancer overexpressed gene 1 protein (sprot)

description: A prostate and breast cancer overexpressed gene 1 protein that is encoded in the genome of human.


name: LOX15_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX15 (sprot)

description: A polyunsaturated fatty acid lipoxygenase ALOX15 that is encoded in the genome of human.


name: CILP2_HUMAN Cartilage intermediate layer protein 2 (sprot)

description: A cartilage intermediate layer protein 2 that is encoded in the genome of human.


name: KGP2_HUMAN cGMP-dependent protein kinase 2 (sprot)

description: A cGMP-dependent protein kinase 2 that is encoded in the genome of human.


phenylarsine oxide

An arsine oxide derived from phenylarsine.


name: SMAD9_HUMAN Mothers against decapentaplegic homolog 9 (sprot)

description: A smad9 that is encoded in the genome of human.


name: MYLIP_HUMAN E3 ubiquitin-protein ligase MYLIP (sprot)

description: An E3 ubiquitin-protein ligase MYLIP that is encoded in the genome of human.


phosphoenolpyruvate

A monocarboxylic acid anion resuting from selective deprotonation of the carboxy group of phosphoenolpyruvic acid.


name: PDGFA_HUMAN Platelet-derived growth factor subunit A (sprot)

description: A platelet-derived growth factor subunit A that is encoded in the genome of human.


sodium periodate

An inorganic sodium salt having periodate as the counterion.


name: OGR1_HUMAN Ovarian cancer G-protein coupled receptor 1 (sprot)

description: A sphingosylphosphorylcholine receptor that is encoded in the genome of human.


pennogenin

An oxaspiro compound that is spirost-5-en substituted by hydroxy groups at positions 3 and 17 (3beta,25R stereoisomer).


tempi syndrome

description: TEMPI syndrome is a rare multi-systemic disease characterized by the presence of Telangiectasias, Erythrocytosis with elevated erythropoietin levels, Monoclonal gammopathy, Perinephric-fluid collections, and Intrapulmonary shunting.


name: TNNT1_HUMAN Troponin T, slow skeletal muscle (sprot)

description: A troponin T, slow skeletal muscle that is encoded in the genome of human.


X3CL1_HUMAN Fractalkine (sprot)

A fractalkine that is encoded in the genome of human.


name: FGF10_HUMAN Fibroblast growth factor 10 (sprot)

description: A fibroblast growth factor 10 that is encoded in the genome of human.


name: CABL1_HUMAN CDK5 and ABL1 enzyme substrate 1 (sprot)

description: A CDK5 and ABL1 enzyme substrate 1 that is encoded in the genome of human.


name: CABL2_HUMAN CDK5 and ABL1 enzyme substrate 2 (sprot)

description: A CDK5 and ABL1 enzyme substrate 2 that is encoded in the genome of human.


name: PROS_HUMAN Vitamin K-dependent protein S (sprot)

description: A vitamin K-dependent protein S that is encoded in the genome of human.


name: MBD3_HUMAN Methyl-CpG-binding domain protein 3 (sprot)

description: A methyl-CpG-binding domain protein 3 that is encoded in the genome of human.


name: PPR3A_HUMAN Protein phosphatase 1 regulatory subunit 3A (sprot)

description: A protein phosphatase 1 regulatory subunit 3A that is encoded in the genome of human.


lymphoblastic lymphoma

description: A lymphoma composed of immature small to medium-sized precursor lymphoid cells (lymphoblasts). It includes the B- and T-cell lymphoblastic lymphoma.


name: PSB10_HUMAN Proteasome subunit beta type-10 (sprot)

description: A proteasome subunit beta type-10 that is encoded in the genome of human.


name: THIK_HUMAN 3-ketoacyl-CoA thiolase, peroxisomal (sprot)

description: A 3-ketoacyl-CoA thiolase, peroxisomal that is encoded in the genome of human.


name: OSGL1_HUMAN tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial (sprot)

description: A tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial that is encoded in the genome of human.


TRIHYDROXYARSENITE(III)

An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.


hypersomnia

description: A sleep disorder characterized by excessive sleepiness.


perfluorononanoic acid

A fluoroalkanoic acid that is nonanoic acid in which all of the hydrogens in the alkyl chain are replaced by fluorines.


vorapaxar

A carbamate ester that is the ethyl ester of [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethynyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamic acid. A protease-activated receptor-1 antagonist used (as its sulfate salt) for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease. It has been shown to reduce the rate of a combined endpoint of cardiovascular death, MI, stroke and urgent coronary revascularisation.


name: SCOT1_HUMAN Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (sprot)

description: A succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial that is encoded in the genome of human.


PSYR_HUMAN Psychosine receptor (sprot)

A psychosine receptor that is encoded in the genome of human.


name: MK11_HUMAN Mitogen-activated protein kinase 11 (sprot)

description: A mitogen-activated protein kinase 11 that is encoded in the genome of human.


cyclothymic disorder

description: An affective disorder characterized by periods of depression and hypomania. These may be separated by periods of normal mood.


name: ELF4_HUMAN ETS-related transcription factor Elf-4 (sprot)

description: An ETS-related transcription factor Elf-4 that is encoded in the genome of human.


name: DYR1A_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1A (sprot)

description: A dual specificity tyrosine-phosphorylation-regulated kinase 1A that is encoded in the genome of human.


myxoid liposarcoma

description: A liposarcoma characterized by the presence of round non-lipogenic primitive mesenchymal cells and small signet ring lipoblasts within a myxoid stoma with a branching vascular pattern. This category includes hypercellular lesions with round cell morphology, formerly known as round cell liposarcoma.


loratadine

A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.


mercuric chloride

A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.


autoimmune myocarditis

description: Autoimmune myocarditis is an autoimmune disease that affects the heart. The condition is characterized by inflammation of the heart muscle (myocardium). Some people with autoimmune myocarditis have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. The exact underlying cause of the condition is currently unknown; however, autoimmune conditions, in general, occur when the immune system mistakenly attacks healthy tissue. Treatment is based on the signs and symptoms present in each person. In some cases, medications that suppress the immune system may be recommended.


name: ARPC2_HUMAN Actin-related protein 2/3 complex subunit 2 (sprot)

description: An actin-related protein 2/3 complex subunit 2 that is encoded in the genome of human.


D-glucose 6-phosphate

A D-glucose monophosphate in which the phosphate group is attached to position 6.


pulmonary tuberculosis

description: A bacterial infection that affects the lungs and is caused by Mycobacterium tuberculosis. Most patients with tuberculosis do not have symptoms (latent tuberculosis) and are not contagious. When signs and symptoms occur (active tuberculosis), patients become contagious. The signs and symptoms include chronic cough with blood-tinged sputum, night sweats, fever, fatigue, and weight loss.


name: ADTRP_HUMAN Androgen-dependent TFPI-regulating protein (sprot)

description: An androgen-dependent TFPI-regulating protein that is encoded in the genome of human.


name: PLPL3_HUMAN 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (sprot)

description: A 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 that is encoded in the genome of human.


name: ENPP2_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (sprot)

description: An ectonucleotide pyrophosphatase/phosphodiesterase family member 2 that is encoded in the genome of human.


name: SCAM1_HUMAN Secretory carrier-associated membrane protein 1 (sprot)

description: A secretory carrier-associated membrane protein 1 that is encoded in the genome of human.


name: NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (sprot)

description: A glutamate receptor ionotropic, NMDA 2A that is encoded in the genome of human.


name: CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1 (sprot)

description: A voltage-dependent L-type calcium channel subunit beta-1 that is encoded in the genome of human.


name: REEP4_HUMAN Receptor expression-enhancing protein 4 (sprot)

description: A receptor expression-enhancing protein 4 that is encoded in the genome of human.


name: MLKL_HUMAN Mixed lineage kinase domain-like protein (sprot)

description: A mixed lineage kinase domain-like protein that is encoded in the genome of human.


name: MEIS3_HUMAN Homeobox protein Meis3 (sprot)

description: A homeobox protein Meis3 that is encoded in the genome of human.


name: PDK4_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (sprot)

description: A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial that is encoded in the genome of human.


arteriolosclerosis

description: The thickening of the wall of the small arteries and arterioles. It is caused by deposition of hyaline material in the wall or concentric smooth muscle wall hypertrophy. It results in lumen narrowing and tissue ischemia.


name: MLXPL_HUMAN Carbohydrate-responsive element-binding protein (sprot)

description: A carbohydrate-responsive element-binding protein that is encoded in the genome of human.


name: SOX12_HUMAN Transcription factor SOX-12 (sprot)

description: A transcription factor SOX-12 that is encoded in the genome of human.


name: MRGX3_HUMAN Mas-related G-protein coupled receptor member X3 (sprot)

description: A Mas-related G-protein coupled receptor X3 that is encoded in the genome of human.


aconitine

A diterpenoid that is 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diol having acetate and benzoate groups at the 8- and 14-positions respectively.


name: NFL_HUMAN Neurofilament light polypeptide (sprot)

description: A neurofilament light polypeptide that is encoded in the genome of human.


azaperone

An N-arylpiperazine that is 2-(piperazin-1-yl)pyridine in which the amino hydrogen is replaced by a 3-(4-fluobenzoyl)propyl group. Used mainly as a tranquiliser for pigs and elephants.


name: K1C16_HUMAN Keratin, type I cytoskeletal 16 (sprot)

description: A keratin, type I cytoskeletal 16 that is encoded in the genome of human.


osteoid osteoma

description: A small, benign, bone-forming neoplasm that can arise from any bone but more frequently affects the long bones. The central portion of the neoplasm (nidus) contains differentiated osteoblasts which produce osteoid and sometimes bone. The lesion is usually surrounded by hypervascular sclerotic bone and has limited growth potential. Clinical signs and symptoms include pain and localized tenderness, at the site of the lesion. The pain may be intense but in the majority of cases it is completely alleviated by non-steroidal anti-inflammatory drugs. Prognosis is excellent and recurrences are rare.


name: LARP1_HUMAN La-related protein 1 (sprot)

description: A La-related protein 1 that is encoded in the genome of human.


PYRROLIDINE

A cyclic amine whose five-membered ring contains four carbon atoms and one nitrogen atom; the parent compound of the pyrrolidine family.


discoid lupus erythematosus

description: A chronic, autoimmune skin condition that manifests with a red, scaling rash, most often found on the face, ears, and scalp; these lesions often lead to permanent scarring and dyspigmentation. Patients may have lesions with or without other symptoms or antibodies suggestive of systemic lupus erythematosus (SLE).


name: CHP1_HUMAN Calcineurin B homologous protein 1 (sprot)

description: A calcineurin B homologous protein 1 that is encoded in the genome of human.


phosphatidylethanolamine (P-18:0/18:1)

A phosphatidylethanolamine P-36:1 in which the 1-alkenyl group contains 18 carbons and no additional double bonds while the acyl group contains 18 carbons and 1 double bond.


name: SPTC2_HUMAN Serine palmitoyltransferase 2 (sprot)

description: A serine palmitoyltransferase 2 that is encoded in the genome of human.


name: ARY1_HUMAN Arylamine N-acetyltransferase 1 (sprot)

description: An arylamine N-acetyltransferase 1 that is encoded in the genome of human.


name: APBP2_HUMAN Amyloid protein-binding protein 2 (sprot)

description: An amyloid protein-binding protein 2 that is encoded in the genome of human.


CATHINONE

The S stereoisomer of 2-aminopropiophenone.


RNAS6_HUMAN Ribonuclease K6 (sprot)

A ribonuclease K6 that is encoded in the genome of human.


name: TIM22_HUMAN Mitochondrial import inner membrane translocase subunit Tim22 (sprot)

description: A mitochondrial import inner membrane translocase subunit Tim22 that is encoded in the genome of human.


name: RAE1_HUMAN Rab proteins geranylgeranyltransferase component A 1 (sprot)

description: A Rab proteins geranylgeranyltransferase component A 1 that is encoded in the genome of human.


name: PIM2_HUMAN Serine/threonine-protein kinase pim-2 (sprot)

description: A serine/threonine-protein kinase Pim-2 that is encoded in the genome of human.


name: CCKAR_HUMAN Cholecystokinin receptor type A (sprot)

description: A cholecystokinin receptor 1 that is encoded in the genome of human.


PHENYLPYRUVATE

A 2-oxo monocarboxylic acid that is 3-phenylpropanoic acid substituted by an oxo group at position 2. It is an intermediate metabolite in the phenylalanine pathway.


name: HCAR3_HUMAN Hydroxycarboxylic acid receptor 3 (sprot)

description: A hydroxycarboxylic acid receptor 3 that is encoded in the genome of human.


Sensory hypersensitivity

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A decreased tolerance to sensory stimuli that triggers emotional and/or physical distress.


glyceraldehyde

An aldotriose comprising propanal having hydroxy groups at the 2- and 3-positions. It plays role in the formation of advanced glycation end-products (AGEs), a deleterious accompaniment to ageing.


name: RAE2_HUMAN Rab proteins geranylgeranyltransferase component A 2 (sprot)

description: A Rab proteins geranylgeranyltransferase component A 2 that is encoded in the genome of human.


name: LIRB3_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 3 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily B member 3 that is encoded in the genome of human.


name: UD17_HUMAN UDP-glucuronosyltransferase 1A7 (sprot)

description: A protein that is a translation product of the UGT1A7 gene in human.


edrophonium

A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.


Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.


multinodular goiter

description: Nodular goiter characterized by more than one discrete tissue mass.


name: GGTA1_HUMAN Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferase (sprot)

description: An inactive N-acetyllactosaminide alpha-1,3-galactosyltransferase that is encoded in the genome of human.


name: PTBP1_HUMAN Polypyrimidine tract-binding protein 1 (sprot)

description: A polypyrimidine tract-binding protein 1 that is encoded in the genome of human.


SDC4_HUMAN Syndecan-4 (sprot)

A syndecan-4 that is encoded in the genome of human.


STOM_HUMAN Stomatin (sprot)

A stomatin that is encoded in the genome of human.


lymphatic malformation 5

description: A frequent form of late-onset, primary lymphedema characterized by lower limb lymphedema typically developing during puberty.


name: TRAP1_HUMAN Heat shock protein 75 kDa, mitochondrial (sprot)

description: A heat shock protein 75 kDa, mitochondrial that is encoded in the genome of human.


name: SENP3_HUMAN Sentrin-specific protease 3 (sprot)

description: A sentrin-specific protease 3 that is encoded in the genome of human.


autoimmune encephalitis

description: Inflammation of the brain secondary to an immune response triggered by the body itself.


astrocytoma (excluding glioblastoma)

description: A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma.


fenticonazole

A racemate comprising equimolar amounts of (R)- and (S)-fenticonazole. Used (as its nitrate salt) for the treatment of vaginal candidiasis.


Diplopia

description: Diplopia is a condition in which a single object is perceived as two images, it is also known as double vision.


name: CCNB2_HUMAN G2/mitotic-specific cyclin-B2 (sprot)

description: A G2/mitotic-specific cyclin-B2 that is encoded in the genome of human.


CO4B_HUMAN Complement C4-B (sprot)

A complement C4-B that is encoded in the genome of human.


ACTN1_HUMAN Alpha-actinin-1 (sprot)

An alpha-actinin-1 that is encoded in the genome of human.


NEUR1_HUMAN Sialidase-1 (sprot)

A sialidase-1 that is encoded in the genome of human.


primary myelofibrosis

description: Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension.


juvenile dermatomyositis

description: Juvenile dermatomyositis (JDM) is the early-onset form of dermatomyositis (DM), a systemic, autoimmune inflammatory muscle disorder, characterized by proximal muscle weakness, evocative skin lesion, and systemic manifestations.


NLGN1_HUMAN Neuroligin-1 (sprot)

A neuroligin-1 that is encoded in the genome of human.


name: MYO7A_HUMAN Unconventional myosin-VIIa (sprot)

description: A myosin-VIIa that is encoded in the genome of human.


hypophosphatemia

description: Lower than normal levels of phosphates in the circulating blood.


name: PPARD_HUMAN Peroxisome proliferator-activated receptor delta (sprot)

description: A peroxisome proliferator-activated receptor delta that is encoded in the genome of human.


name: XBP1_HUMAN X-box-binding protein 1 (sprot)

description: An X-box-binding protein 1 that is encoded in the genome of human.


name: GRP75_HUMAN Stress-70 protein, mitochondrial (sprot)

description: A stress-70 protein, mitochondrial that is encoded in the genome of human.


name: NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6 (sprot)

description: An NADH-ubiquinone oxidoreductase chain 6 that is encoded in the genome of human.


transitional cell carcinoma

description: A malignant neoplasm arising from the transitional epithelium, usually affecting the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary configuration. It is graded 1 to 3 or 4 according to the degree of cellular differentiation and architectural patterns. Grade 1 transitional cell carcinoma is histologically benign but it may recur. Transitional cell carcinomas may also affect the upper respiratory tract and the ovaries.


didanosine

A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.


PKHD1_HUMAN Fibrocystin (sprot)

A fibrocystin that is encoded in the genome of human.


name: TR10B_HUMAN Tumor necrosis factor receptor superfamily member 10B (sprot)

description: A tumor necrosis factor receptor superfamily member 10B that is encoded in the genome of human.


Facial hemangioma

description: Hemangioma, a benign tumor of the vascular endothelial cells, occurring in the face.


name: K1C10_HUMAN Keratin, type I cytoskeletal 10 (sprot)

description: A keratin, type I cytoskeletal 10 that is encoded in the genome of human.


LORI_HUMAN Loricrin (sprot)

A loricrin that is encoded in the genome of human.


S10A9_HUMAN Protein S100-A9 (sprot)

A protein S100-A9 that is encoded in the genome of human.


critical illness polyneuropathy

description: Polyneuropathy arising in intensive care unit patients.  It is a common complication of severe sepsis and is thought to represent a neurologic manifestation of systemic inflammatory response syndrome (SIRS).


name: PMS2_HUMAN Mismatch repair endonuclease PMS2 (sprot)

description: A mismatch repair endonuclease PMS2 that is encoded in the genome of human.


name: PREX1_HUMAN Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (sprot)

description: A phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein that is encoded in the genome of human.


An amino phenol (one of the three possible isomers) which has the single amino substituent located para to the phenolic -OH group.


name: MC4R_HUMAN Melanocortin receptor 4 (sprot)

description: A melanocortin receptor 4 that is encoded in the genome of human.


Apathy

description: Apathy is a quantitative reduction of motivation and the initiation and persistence of goal-directed behavior, where the accompanying emotions, thoughts, and social interactions are also suppressed.


COL12_HUMAN Collectin-12 (sprot)

A collectin-12 that is encoded in the genome of human.


name: FIP1_HUMAN Pre-mRNA 3'-end-processing factor FIP1 (sprot)

description: A pre-mRNA 3'-end-processing factor FIP1 that is encoded in the genome of human.


DIHYDROLIPOIC ACID

The (R)-enantiomer and bioactive form of dihydrolipoic acid.


bronchopneumonia

description: Acute inflammation of the walls of the terminal bronchioles that spreads into the peribronchial alveoli and alveolar ducts. It results in the creation of foci of consolidation, which are surrounded by normal parenchyma. It affects one or more lobes, and is frequently bilateral and basal. It is usually caused by bacteria (e.g., Staphylococcus, Streptococcus, Haemophilus influenzae). Signs and symptoms include fever, cough with production of brown-red sputum, dyspnea, and chest pain.


name: Schistosoma japonicum infectious disease

description: An infection that is caused by Schistosoma japonicum.


Atherosclerotic lesion

description: A lesion associated with atherosclerosis, a multifactorial and multipart progressive disease manifested by the focal development within the arterial wall of lesions, that ranges from teh development of a fatty streak, plaque progression, and plaque disruption. Atherosclerotic lesions demonstrate consistent morphological characteristics, which indicate that each type may stabilize temporarily or permanently and that progression to the next type may require an additional stimulus.


name: GA45B_HUMAN Growth arrest and DNA damage-inducible protein GADD45 beta (sprot)

description: A growth arrest and DNA damage-inducible protein GADD45 beta that is encoded in the genome of human.


name: API5_HUMAN Apoptosis inhibitor 5 (sprot)

description: An apoptosis inhibitor 5 that is encoded in the genome of human.


ANO1_HUMAN Anoctamin-1 (sprot)

An anoctamin-1 that is encoded in the genome of human.


SGO1_HUMAN Shugoshin 1 (sprot)

A shugoshin 1 that is encoded in the genome of human.


omacetaxine mepesuccinate

A cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia.


styrene oxide

An epoxide that is oxirane in which one of the hydrogens has been replaced by a phenyl group.


name: I17RB_HUMAN Interleukin-17 receptor B (sprot)

description: An interleukin-17 receptor B that is encoded in the genome of human.


HEXANE

An unbranched alkane containing six carbon atoms.


name: LRRN2_HUMAN Leucine-rich repeat neuronal protein 2 (sprot)

description: A leucine-rich repeat neuronal protein 2 that is encoded in the genome of human.


XKR8_HUMAN XK-related protein 8 (sprot)

An XK-related protein 8 that is encoded in the genome of human.


mexiletine

An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.


nodular non-suppurative panniculitis

description: Nodular non-suppurative panniculitis, known as Weber-Christian disease (WCD), is a rare skin disorder characterized by recurring inflammation in the subcutaneous layer of fat.


AMBP_HUMAN Protein AMBP (sprot)

A protein AMBP that is encoded in the genome of human.


name: PCBP2_HUMAN Poly(rC)-binding protein 2 (sprot)

description: A poly(rC)-binding protein 2 that is encoded in the genome of human.


name: IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (sprot)

description: An isocitrate dehydrogenase [NADP] cytoplasmic that is encoded in the genome of human.


NF1_HUMAN Neurofibromin (sprot)

A neurofibromin that is encoded in the genome of human.


osteochondrosis

description: A condition that is characterized by defective bone growth that affects the growth centers of bone.


name: PPT1_HUMAN Palmitoyl-protein thioesterase 1 (sprot)

description: A palmitoyl-protein thioesterase 1 that is encoded in the genome of human.


name: BIN1_HUMAN Myc box-dependent-interacting protein 1 (sprot)

description: A Myc box-dependent-interacting protein 1 that is encoded in the genome of human.


name: TBX4_HUMAN T-box transcription factor TBX4 (sprot)

description: A T-box transcription factor TBX4 that is encoded in the genome of human.


name: PIGF_HUMAN Phosphatidylinositol-glycan biosynthesis class F protein (sprot)

description: A phosphatidylinositol-glycan biosynthesis class F protein that is encoded in the genome of human.


phosphatidylethanolamine (18:1/22:0)

A phosphatidylethanolamine 40:1 in which the acyl group at C-1 contains 18 carbons and 1 double bond while that at C-2 contains 22 carbons and no double bonds.


name: AJUBA_HUMAN LIM domain-containing protein ajuba (sprot)

description: A protein ajuba that is encoded in the genome of human.


name: UBP8_HUMAN Ubiquitin carboxyl-terminal hydrolase 8 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 8 that is encoded in the genome of human.


OXALIC ACID

An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2.


Epidural hemorrhage

description: Hemorrhage occurring between the dura mater and the skull.


myotonic dystrophy

description: An inherited progressive disorder affecting the muscles. It is characterized by muscle wasting and hypotonia, cataracts, heart conduction defects and endocrinopathies.


phosphatidylethanolamine (P-16:0/18:1)

A phosphatidylethanolamine P-34:1 in which the 1-alkenyl group contains 16 carbons and no additional double bonds while the acyl group contains 18 carbons and 1 double bond.


phenoxyethanol

An aromatic ether that is phenol substituted on oxygen by a 2-hydroxyethyl group.


name: NALP2_HUMAN NACHT, LRR and PYD domains-containing protein 2 (sprot)

description: A NACHT, LRR and PYD domains-containing protein 2 that is encoded in the genome of human.


phosphatidic acid (16:0/18:1)

A phosphatidic acid in which one acyl group has 16 carbons and is fully saturated while the other has 18 carbons and 1 double bond.


picropodophyllin

An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents.


familial hypocalciuric hypercalcemia

description: Familial hypocalciuric hypercalcemia (FHH) is a generally asymptomatic genetic disorder of phosphocalcic metabolism characterized by lifelong moderate hypercalcemia along with normo- or hypocalciuria and elevated plasma parathyroid hormone (PTH) concentration.


tafamidis

A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis.


name: EVX1_HUMAN Homeobox even-skipped homolog protein 1 (sprot)

description: A homeobox even-skipped homolog protein 1 that is encoded in the genome of human.


name: NHRF3_HUMAN Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (sprot)

description: A Na(+)/H(+) exchange regulatory cofactor NHE-RF3 that is encoded in the genome of human.


name: RN138_HUMAN E3 ubiquitin-protein ligase RNF138 (sprot)

description: An E3 ubiquitin-protein ligase RNF138 that is encoded in the genome of human.


name: AEBP1_HUMAN Adipocyte enhancer-binding protein 1 (sprot)

description: An adipocyte enhancer-binding protein 1 that is encoded in the genome of human.


PLXB2_HUMAN Plexin-B2 (sprot)

A plexin-B2 that is encoded in the genome of human.


PLXD1_HUMAN Plexin-D1 (sprot)

A plexin-D1 that is encoded in the genome of human.


delavirdine

The amide resulting from the formal condensation of 5-[(methylsulfonyl)amino]-1H-indole-2-carboxylic acid and 4-amino group of 1-[3-(isopropylamino)pyridin-2-yl]piperazine, delavirdine is a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection.


name: ATP7A_HUMAN Copper-transporting ATPase 1 (sprot)

description: A copper-transporting ATPase 1 that is encoded in the genome of human.


APOM_HUMAN Apolipoprotein M (sprot)

An apolipoprotein M that is encoded in the genome of human.


hepatitis A virus infection

description: Acute inflammation of the liver caused by the hepatitis A virus. It is highly contagious and usually contracted through close contact with an infected individual or their feces, contaminated food or water.


Glomerulomegaly

description: Abnormally large size of glomeruli.


name: PHF11_HUMAN PHD finger protein 11 (sprot)

description: A PHD finger protein 11 that is encoded in the genome of human.


name: BCAP_HUMAN Phosphoinositide 3-kinase adapter protein 1 (sprot)

description: A phosphoinositide 3-kinase adapter protein 1 that is encoded in the genome of human.


preeclampsia

description: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.


name: von Willebrand disease (hereditary or acquired)

description: Hereditary or acquired coagulation disorder characterized by a qualitative or quantitative deficiency of the von Willebrand factor. The latter plays an important role in platelet adhesion. Signs and symptoms include bruises, nose bleeding, gum bleeding following a dental procedure, heavy menstrual bleeding, and gastrointestinal bleeding.


name: ST2A1_HUMAN Sulfotransferase 2A1 (sprot)

description: A sulfotransferase 2A1 that is encoded in the genome of human.


pimozide

A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which one of the nitrogens is substituted by a piperidin-4-yl group, which in turn is substituted on the nitrogen by a 4,4-bis(p-fluorophenyl)butyl group.


RETN_HUMAN Resistin (sprot)

A resistin that is encoded in the genome of human.


name: SCO2_HUMAN Protein SCO2 homolog, mitochondrial (sprot)

description: A protein SCO2, mitochondrial that is encoded in the genome of human.


loperamide

A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.


name: KIF5A_HUMAN Kinesin heavy chain isoform 5A (sprot)

description: A kinesin heavy chain isoform 5A that is encoded in the genome of human.


name: TBC3C_HUMAN TBC1 domain family member 3C (sprot)

description: A TBC1 domain family member 3C/3D that is encoded in the genome of human.


diphenylcyclopropenone

A cyclopropenone compound having phenyl substituents at the 2- and 3-positions.


name: CDR1_HUMAN Cerebellar degeneration-related antigen 1 (sprot)

description: A cerebellar degeneration-related antigen 1 that is encoded in the genome of human.


name: RPGF2_HUMAN Rap guanine nucleotide exchange factor 2 (sprot)

description: A Rap guanine nucleotide exchange factor 2 that is encoded in the genome of human.


kidney Wilms tumor

description: An embryonal pediatric tumor of the kidney which may also be seen rarely in adults. The peak incidence of Wilms tumor is between the second and fifth year of life. Microscopically, it is composed of a mixture of cellular elements (blastemal, stromal, and epithelial). The most common sites of metastasis include the regional lymph nodes, lungs, and liver.


name: MSL2_HUMAN E3 ubiquitin-protein ligase MSL2 (sprot)

description: An E3 ubiquitin-protein ligase MSL2 that is encoded in the genome of human.


aloin

A diastereoisomeric mixture of aloin A (barbaloin) and aloin B (isobarbaloin), which have similar properties. It is a bitter-tasting, yellow-brown colored compound found in the exudate of at least 68 Aloe species at levels of up to 6.6% of leaf dry weight (making between 3% and 35% of the total exudate), and in another 17 species at indeterminate levels. It is used as a stimulant-laxative, treating constipation by inducing bowel movements.


name: TREX1_HUMAN Three-prime repair exonuclease 1 (sprot)

description: A three-prime repair exonuclease 1 that is encoded in the genome of human.


name: CHST6_HUMAN Carbohydrate sulfotransferase 6 (sprot)

description: A carbohydrate sulfotransferase 6 that is encoded in the genome of human.


name: CSK21_HUMAN Casein kinase II subunit alpha (sprot)

description: A casein kinase II subunit alpha that is encoded in the genome of human.


name: ASIC2_HUMAN Acid-sensing ion channel 2 (sprot)

description: An acid-sensing ion channel 2 that is encoded in the genome of human.


name: RIGI_HUMAN Antiviral innate immune response receptor RIG-I (sprot)

description: An antiviral innate immune response receptor RIG-I that is encoded in the genome of human.


Arterial dissection

description: A separation (dissection) of the layers of an artery.


A tetrapeptide that is isolated from the sea hare Dolabella auricularia. It is a potent anticancer agent which inhibits tubulin polymerization.


fungal meningitis

description: Meningitis caused by fungal agents which may occur as opportunistic infections or arise in immunocompetent hosts.


dicloxacillin

A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]formyl group.


name: GPR52_HUMAN G-protein coupled receptor 52 (sprot)

description: A G-protein coupled receptor 52 that is encoded in the genome of human.


name: HERP1_HUMAN Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (sprot)

description: A homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein that is encoded in the genome of human.


low grade glioma

description: A grade I or grade II glioma arising from the central nervous system. This category includes pilocytic astrocytoma, diffuse astrocytoma, subependymal giant cell astrocytoma, ependymoma, oligodendroglioma, oligoastrocytoma, and angiocentric glioma.


PLIN2_HUMAN Perilipin-2 (sprot)

A perilipin-2 that is encoded in the genome of human.


calcium gluconate

The calcium salt of D-gluconic acid.


name: PLCA_HUMAN 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (sprot)

description: A 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha that is encoded in the genome of human.


perflexane

A fluoroalkane that is hexane in which all of the hydrogens have been replaced by fluorines.


pasireotide

A six-membered homodetic cyclic peptide composed from L-phenylglycyl, D-tryptophyl, L-lysyl, O-benzyl-L-tyrosyl, L-phenylalanyl and modified L-hydroxyproline residues joined in sequence. A somatostatin analogue with pharmacologic properties mimicking those of the natural hormone somatostatin; used (as its diaspartate salt) for treatment of Cushing's disease.


O-CHLOROACETYLCARBAMOYLFUMAGILLOL

A carbamate ester that is fumagillol in which the hydroxy group has been converted to the corresponding N-(chloroacetyl)carbamate derivative.


cutaneous mastocytosis

description: Cutaneous mastocytosis is a term referring to a group of diseases characterized by abnormal accumulation and proliferation of skin mastocytes. In some cases (most commonly in adults), cutaneous mastocytosis may occur in association with mast cell infiltration of various extracutaneous organs, in which case the disorder is referred to as systemic mastocytosis.


pramipexole

A member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively.


cerebral malaria

description: A sequestration of Plasmodium falciparum in the brain, which can cause coma and/or seizures.


polycystic kidney disease

description: A usually autosomal dominant and less frequently autosomal recessive genetic disorder characterized by the presence of numerous cysts in the kidneys leading to end-stage renal failure. The autosomal dominant trait is associated with abnormalities on the short arm of chromosome 16. Symptoms in patients with the autosomal dominant trait usually appear at middle age and include abdominal pain, hematuria, and high blood pressure. Patients may develop brain aneurysms and liver cysts. Patients with the autosomal recessive trait present with progressive renal failure early in life and symptoms resulting from hepatic fibrosis. The autosomal recessive trait is associated with abnormalities of chromosome 6. Polycystic kidney disease may also result as a side effect in patients on renal dialysis.


name: MAMD1_HUMAN Mastermind-like domain-containing protein 1 (sprot)

description: A mastermind-like domain-containing protein 1 that is encoded in the genome of human.


name: PEBB_HUMAN Core-binding factor subunit beta (sprot)

description: A core-binding factor subunit beta that is encoded in the genome of human.


etoricoxib

A member of the class of bipyridines that is 2,3'-bipyridine which is substituted at the 3, 5, and 6' positions by 4-(methylsulfonyl)phenyl, chlorine, and methyl groups, respectively.


name: K1C20_HUMAN Keratin, type I cytoskeletal 20 (sprot)

description: A keratin, type I cytoskeletal 20 that is encoded in the genome of human.


PTTG1_HUMAN Securin (sprot)

A securin that is encoded in the genome of human.


name: REEP2_HUMAN Receptor expression-enhancing protein 2 (sprot)

description: A receptor expression-enhancing protein 2 that is encoded in the genome of human.


name: RFA1_HUMAN Replication protein A 70 kDa DNA-binding subunit (sprot)

description: A replication protein A 70 kDa DNA-binding subunit that is encoded in the genome of human.


pacritinib

An azamacrocycle with formula C28H32N4O3. It is a Janus kinase inhibitor and its citrate salt is approved for the treatment of intermediate or high risk, primary or secondary myelofibrosis.


name: FER_HUMAN Tyrosine-protein kinase Fer (sprot)

description: A tyrosine-protein kinase Fer that is encoded in the genome of human.


CLD8_HUMAN Claudin-8 (sprot)

A claudin-8 that is encoded in the genome of human.


iris melanoma

description: A uveal melanoma that arises from the iris. It is the most common primary malignant neoplasm of the iris. The majority arise in preexisting nevi.


sofosbuvir

A nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.


name: HEY1_HUMAN Hairy/enhancer-of-split related with YRPW motif protein 1 (sprot)

description: A hairy/enhancer-of-split related with YRPW motif protein 1 that is encoded in the genome of human.


common variable immunodeficiency

description: Common variable immunodeficiency (CVID) comprises a heterogeneous group of diseases characterized by a significant hypogammaglobulinemia of unknown cause, failure to produce specific antibodies after immunizations and susceptibility to bacterial infections, predominantly caused by encapsulated bacteria.


name: pseudoxanthoma elasticum (inherited or acquired)

description: An inherited disorder that causes calcium and other minerals to accumulate in the elastic fibers of the skin, eyes, and blood vessels, and less frequently in other areas such as the digestive tract.


neovascular glaucoma

description: Neovascular glaucoma is the most common type of secondary glaucoma, usually caused by diabetic retinopathy, central retinal vein occlusion and carotid artery obstruction but sometimes by trauma, uvietis or ocular tumors, and characterized by severe eye pain, synechial angle glaucoma, high intraocular pressure and leading to loss of vision.


parkinsonian disorder

description: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.


daptomycin

A polypeptide comprising N-decanoyltryptophan, asparagine, aspartic acid, threonine, glycine, ornithine, aspartic acid, D-alanine, aspartic acid, glycine, D-serine, threo-3-methylglutamic acid and 3-anthraniloylalanine (also known as kynurinine) coupled in sequence and lactonised by condensation of the carboxylic acid group of the 3-anthraniloylalanine  with the alcohol group of the threonine residue.


rasagiline

An indane that consists of 1-aminoindane bearing an N-propargyl substituent. A selective, irreversible monoamine oxidase-B inhibitor.


name: idiopathic pulmonary arterial hypertension

description: Idiopathic pulmonary arterial hypertension (IPAH) is a sporadic form of pulmonary arterial hypertension (PAH) characterized by elevated pulmonary arterial resistance leading to right heart failure. IPAH is progressive and potentially fatal and not associated with an underlying condition or family history of PAH.


name: TDGF3_HUMAN Putative protein CRIPTO3 (sprot)

description: A putative protein CRIPTO3 that is encoded in the genome of human.


tafenoquine

A racemate comprising equimolar amounts of (R)- and (S)-tafenoquine.


name: TRPM6_HUMAN Transient receptor potential cation channel subfamily M member 6 (sprot)

description: A transient receptor potential cation channel subfamily M member 6 that is encoded in the genome of human.


lonafarnib

A 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide that has R configuration. It is used as oral farnesyltransferase inhibitor.


adult glioblastoma

description: A glioblastoma occurring in adults.


name: LIRB2_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 2 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily B member 2 that is encoded in the genome of human.


name: SYTL2_HUMAN Synaptotagmin-like protein 2 (sprot)

description: A synaptotagmin-like protein 2 that is encoded in the genome of human.


name: RIT2_HUMAN GTP-binding protein Rit2 (sprot)

description: A GTP-binding protein Rit2 that is encoded in the genome of human.


neural tube defect

description: A congenital defect characterized by failure of the neural tube to close completely; this results in the presence of openings in the brain or spinal cord. Examples of neural tube defects include encephalocele and spina bifida.


WFS1_HUMAN Wolframin (sprot)

A wolframin that is encoded in the genome of human.


name: MBOA7_HUMAN Lysophospholipid acyltransferase 7 (sprot)

description: A lysophospholipid acyltransferase 7 that is encoded in the genome of human.


PHF1_HUMAN PHD finger protein 1 (sprot)

A PHD finger protein 1 that is encoded in the genome of human.


elvitegravir

A quinolinemonocarboxylic acid that is 7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid substited at position 1 by a 1-hydroxy-3-methylbutan-2-yl group and at position 6 by a 3-chloro-2-fluorobenzyl group (the S-enantiomer). It is used in combination therapy for the treatment of HIV-1 infection.


droperidol

An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.


name: LPAR4_HUMAN Lysophosphatidic acid receptor 4 (sprot)

description: A lysophosphatidic acid receptor 4 that is encoded in the genome of human.


short QT syndrome

description: A genetic disease of the electrical system of the heart that consists of a constellation of signs and symptoms, consisting of a short QT interval on an EKG (< 300 ms) that does not significantly change with heart rate, tall and peaked T waves, and a structurally normal heart. Short QT syndrome appears to be inherited in an autosomal dominant pattern, and a few affected families have been identified


BIS(ETHYL)NORSPERMINE

N(1),N(11)-bis(ethyl)norspermine (DENSPM), a N-terminally alkylated tetraamine and polyamine mimetics, disrupts polyamine pool homeostasis by modulating the activities of the biosynthetic enzymes, ornithine decarboxylase (ODC), and S-adenosylmethionine decarboxylase (AdoMetDC).


name: CRYAB_HUMAN Alpha-crystallin B chain (sprot)

description: An alpha-crystallin B chain that is encoded in the genome of human.


name: PYDC2_HUMAN Pyrin domain-containing protein 2 (sprot)

description: A pyrin domain-containing protein 2 that is encoded in the genome of human.


name: HSF4_HUMAN Heat shock factor protein 4 (sprot)

description: A heat shock factor protein 4 that is encoded in the genome of human.


name: UBP2_HUMAN Ubiquitin carboxyl-terminal hydrolase 2 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 2 that is encoded in the genome of human.


name: PLPP1_HUMAN Phospholipid phosphatase 1 (sprot)

description: A phospholipid phosphatase 1 that is encoded in the genome of human.


name: CATC_HUMAN Dipeptidyl peptidase 1 (sprot)

description: A dipeptidyl peptidase 1 that is encoded in the genome of human.


phosphatidylcholine (18:1/19:1)

A phosphatidylcholine 37:2 in which the fatty acyl groups at positions 1 and 2 are specified as C18:1 and C19:1 respectively.


promethazine

A  tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.


Ventricular arrhythmia

description: A disorder characterized by an electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles.


HUNIN_HUMAN Humanin (sprot)

A humanin that is encoded in the genome of human.


name: KIF7_HUMAN Kinesin-like protein KIF7 (sprot)

description: A kinesin-like protein KIF7 that is encoded in the genome of human.


name: HNRH1_HUMAN Heterogeneous nuclear ribonucleoprotein H (sprot)

description: A heterogeneous nuclear ribonucleoprotein H that is encoded in the genome of human.


name: NTR2_HUMAN Neurotensin receptor type 2 (sprot)

description: A neurotensin receptor type 2 that is encoded in the genome of human.


name: C4BPB_HUMAN C4b-binding protein beta chain (sprot)

description: A C4b-binding protein beta chain that is encoded in the genome of human.


ERLN2_HUMAN Erlin-2 (sprot)

An erlin-2 that is encoded in the genome of human.


name: TIA1_HUMAN Cytotoxic granule associated RNA binding protein TIA1 (sprot)

description: A cytotoxic granule associated RNA binding protein TIA1 that is encoded in the genome of human.


name: GXLT1_HUMAN Glucoside xylosyltransferase 1 (sprot)

description: A glucoside xylosyltransferase 1 that is encoded in the genome of human.


name: XXLT1_HUMAN Xyloside xylosyltransferase 1 (sprot)

description: A xyloside xylosyltransferase 1 that is encoded in the genome of human.


tolbutamide

An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.


sulfadimethoxine

A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.


urocanic acid

An alpha,beta-unsaturated monocarboxylic acid that is prop-2-enoic acid substituted by a 1H-imidazol-4-yl group at position 3. It is a metabolite of hidtidine.


Smith-Lemli-Opitz syndrome

description: Smith-Lemli-Opitz syndrome (SLOS) is characterized by multiple congenital anomalies, intellectual deficit, and behavioral problems.


Hypokinesia

description: Abnormally diminished motor activity. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency.


name: DFFA_HUMAN DNA fragmentation factor subunit alpha (sprot)

description: A DNA fragmentation factor subunit alpha that is encoded in the genome of human.


RESINIFERATOXIN

A heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1).


SSPN_HUMAN Sarcospan (sprot)

A sarcospan that is encoded in the genome of human.


Inflammatory myopathy

description: Chronic muscle inflammation accompanied by muscle weakness.


Ovarian fibrosis

description: Excessive proliferation of fibroblasts and deposition of extracellular matrix within the ovary.


name: ATPA_HUMAN ATP synthase subunit alpha, mitochondrial (sprot)

description: An ATP synthase subunit alpha, mitochondrial that is encoded in the genome of human.


intravenous leiomyomatosis

description: A rare benign neoplasm characterized by the presence of smooth muscle cells growing within veins.


name: COLQ_HUMAN Acetylcholinesterase collagenic tail peptide (sprot)

description: An acetylcholinesterase collagenic tail peptide that is encoded in the genome of human.


Axial dystonia

description: A type of dystonia that affects the midline muscles, i.e., the chest, abdominal, and back muscles.


tenosynovial giant cell tumor

description: A tumor usually arising in the synovium of joints, bursa or tendon sheath. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. According to the growth pattern, it is classified as localized or diffuse.


Ischemic stroke

description: Acute ischemic stroke (AIS) is defined by the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. It is caused by thrombosis or embolism that occludes a cerebral vessel supplying a specific area of the brain. During a vessel occlusion, there is a core area where damage to the brain is irreversible and an area of penumbra where the brain has lost function owing to decreased blood flow but is not irreversibly injured.


name: CRIS1_HUMAN Cysteine-rich secretory protein 1 (sprot)

description: A cysteine-rich secretory protein 1 that is encoded in the genome of human.


name: CLIC2_HUMAN Chloride intracellular channel protein 2 (sprot)

description: A chloride intracellular channel protein 2 that is encoded in the genome of human.


name: SULF2_HUMAN Extracellular sulfatase Sulf-2 (sprot)

description: An extracellular sulfatase Sulf-2 that is encoded in the genome of human.


fluorescein

A xanthene dye that is highly fluorescent, detectable even when present in minute quantities. Used forensically to detect traces of blood, in analytical chemistry as an indicator in silver nitrate titrations and in microscopy.


name: GBRAP_HUMAN Gamma-aminobutyric acid receptor-associated protein (sprot)

description: A gamma-aminobutyric acid receptor-associated protein that is encoded in the genome of human.


CASTICIN

A tetramethoxyflavone that consists of quercetagetin in which the hydroxy groups at positions 3, 6, 7 and 4' have been replaced by methoxy groups. It has been isolated from Eremophila mitchellii.


Danon disease

description: A lysosomal glycogen storage disease characterized by severe cardiomyopathy and variable degrees of muscle weakness, frequently associated with intellectual deficit.


name: WWTR1_HUMAN WW domain-containing transcription regulator protein 1 (sprot)

description: A WW domain-containing transcription regulator protein 1 that is encoded in the genome of human.


name: MCR_HUMAN Mineralocorticoid receptor (sprot)

description: A mineralocorticoid receptor that is encoded in the genome of human.


SNN_HUMAN Stannin (sprot)

A stannin that is encoded in the genome of human.


meningeal tuberculosis

description: A bacterial infection of the membranes covering the brain and the spinal cord caused by Mycobacterium tuberculosis.


fenofibric acid

A monocarboxylic acid that is 2-methylpropanoic acid substituted by a 4-(4-chlorobenzoyl)phenoxy group at position 2. It is a metabolite of the drug fenofibrate.


LIDOCAINE HYDROCHLORIDE

The anhydrous form of the hydrochloride salt of lidocaine.


Chronic infection

description: Presence of a protracted or persistent infection by a pathogen potentially related to an underlying abnormality of the immune system that is not able to clear the infection.


name: RPGP2_HUMAN Rap1 GTPase-activating protein 2 (sprot)

description: A Rap1 GTPase-activating protein 2 that is encoded in the genome of human.


name: TRIM5_HUMAN Tripartite motif-containing protein 5 (sprot)

description: A tripartite motif-containing protein 5 that is encoded in the genome of human.


name: KS6A1_HUMAN Ribosomal protein S6 kinase alpha-1 (sprot)

description: A ribosomal protein S6 kinase alpha-1 that is encoded in the genome of human.


orciprenaline

A racemate composed of equimolar amounts of (R)- and (S)-orciprenaline. Used (as its sulfate salt) to relax the airway muscles and improve breathing for patients suffering from asthma or bronchitis.


name: PPGB_HUMAN Lysosomal protective protein (sprot)

description: A lysosomal protective protein that is encoded in the genome of human.


name: RS10_HUMAN Small ribosomal subunit protein eS10 (sprot)

description: A small ribosomal subunit protein eS10 that is encoded in the genome of human.


sucroferric oxyhydroxide

An iron oxide of nanoparticulate size and poor crystallinity. It is a mineral commonly found in soil and freshwater environments and forms a core structural component in the Fe-buffering ferritin protein. It is also used in the sequestration of heavy element contaminants, and is a precursor of haematite and goethite.


undecanoic acid

A straight-chain, eleven-carbon saturated medium-chain fatty acid found in body fluids; the most fungitoxic of the C7:0 - C18:0 fatty acid series.


SAPACITABINE

A nucleoside analogue resulting from the formal condensation of the carboxy group of hexadecanoic acid with the amino group of CNDAC. It is the prodrug of CNDAC and is currently in clinical development for the treatment of acute myeloid leukemia (AML).


name: COBA1_HUMAN Collagen alpha-1(XI) chain (sprot)

description: A collagen alpha-1(XI) chain that is encoded in the genome of human.


name: ERR1_HUMAN Steroid hormone receptor ERR1 (sprot)

description: A steroid hormone receptor ERR1 that is encoded in the genome of human.


name: 5HT7R_HUMAN 5-hydroxytryptamine receptor 7 (sprot)

description: A 5-hydroxytryptamine receptor 7 that is encoded in the genome of human.


name: FOLR1_HUMAN Folate receptor alpha (sprot)

description: A folate receptor alpha that is encoded in the genome of human.


name: UBP7_HUMAN Ubiquitin carboxyl-terminal hydrolase 7 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 7 that is encoded in the genome of human.


niclosamide

A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.


mefloquine

An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4.


ANK1_HUMAN Ankyrin-1 (sprot)

An ankyrin-1 that is encoded in the genome of human.


name: IBP5_HUMAN Insulin-like growth factor-binding protein 5 (sprot)

description: An insulin-like growth factor-binding protein 5 that is encoded in the genome of human.


viral pneumonia

description: Inflammation of the lung parenchyma that is caused by a viral infection.


name: PYC_HUMAN Pyruvate carboxylase, mitochondrial (sprot)

description: A pyruvate carboxylase, mitochondrial that is encoded in the genome of human.


Recurrent skin infections

description: Infections of the skin that happen multiple times.


Anterior subcapsular cataract

description: A type of cataract affecting the anterior pole of lens immediately adjacent to ('beneath') the lens capsule.


phosphatidylinositol (18:2/18:2)

A phosphatidylinositol 36:4 in which both acyl groups contain 18 carbons and 2 double bonds.


sotorasib

A pyridopyrimidine that is pyrido[2,3-d]pyrimidin-2(1H)-one substituted by 4-methyl-2-(propan-2-yl)pyridin-3-yl, (2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl, fluoro and 2-fluoro-6-hydroxyphenyl groups at positions 1, 4, 6 and 7, respectively. It is approved for the treatment of patients with non-small cell lung cancer having KRAS(G12C) mutations.


name: SH3L3_HUMAN SH3 domain-binding glutamic acid-rich-like protein 3 (sprot)

description: An SH3 domain-binding glutamic acid-rich-like protein 3 that is encoded in the genome of human.


Macrovesicular hepatic steatosis

description: A form of hepatic steatosis characterized by the presence of large, lipid-laden vesicles in the affected hepatocytes.


CD4+/CD56+ hematodermic neoplasm

description: An aggressive immature hematologic neoplasm formerly known as blastic NK cell lymphoma, composed of cells with a lymphoblast-like morphology. Recent evidence suggests derivation from a plasmacytoid monocyte. Patients present with cutaneous tumors and bone marrow involvement.


name: TNNI3_HUMAN Troponin I, cardiac muscle (sprot)

description: A troponin I, cardiac muscle that is encoded in the genome of human.


oculopharyngeal muscular dystrophy

description: Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset progressive myopathy characterized by progressive eyelid ptosis, dysphagia, dysarthria and proximal limb weakness.


name: PHF12_HUMAN PHD finger protein 12 (sprot)

description: A PHD finger protein 12 that is encoded in the genome of human.


aggressive NK-cell leukemia

description: A rare, highly aggressive, Epstein-Barr virus-associated leukemia, also known as aggressive NK-cell leukemia/lymphoma; it may represent the leukemic counterpart of nasal type extranodal NK/T-cell lymphomas. It affects primarily teenagers and young adults. It is characterized by the systemic proliferation of NK cells in the peripheral blood, bone marrow, liver, and spleen.


name: PROP1_HUMAN Homeobox protein prophet of Pit-1 (sprot)

description: A homeobox protein prophet of Pit-1 that is encoded in the genome of human.


name: TBPL2_HUMAN TATA box-binding protein-like 2 (sprot)

description: A TATA box-binding protein-like 2 that is encoded in the genome of human.


pefloxacin

A quinolone that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6 and 7 by ethyl, carboxy, fluorine, and 4-methylpiperazin-1-yl groups, respectively.


name: RBBP6_HUMAN E3 ubiquitin-protein ligase RBBP6 (sprot)

description: An E3 ubiquitin-protein ligase RBBP6 that is encoded in the genome of human.


name: LEU1_HUMAN Leukemia-associated protein 1 (sprot)

description: A leukemia-associated protein 1 that is encoded in the genome of human.


fusidic acid

A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.


name: GABR1_HUMAN Gamma-aminobutyric acid type B receptor subunit 1 (sprot)

description: A gamma-aminobutyric acid type B receptor subunit 1 that is encoded in the genome of human.


wet macular degeneration

description: A form of RETINAL degeneration in which abnormal CHOROIDAL NEOVASCULARIZATION occurs under the RETINA and MACULA LUTEA, causing bleeding and leaking of fluid. This leads to bulging and or lifting of the macula and the distortion or destruction of central vision.


name: Ph-positive acute lymphoblastic leukemia

description: A subset of acute lymphoblastic leukemia that results from a reciprocal translocation between the ABL-1 oncogene and a breakpoint cluster region (BCR), resulting in a fusion gene, BCR-ABL, that encodes an oncogenic protein with constitutively active tyrosine kinase activity.


vitamin D deficiency

description: Abnormally low level of 25-hydroxyvitamin D in the blood.


SLPI_HUMAN Antileukoproteinase (sprot)

An antileukoproteinase that is encoded in the genome of human.


name: NUD11_HUMAN Diphosphoinositol polyphosphate phosphohydrolase 3-beta (sprot)

description: A diphosphoinositol polyphosphate phosphohydrolase 3-beta that is encoded in the genome of human.


name: NPY42_HUMAN Neuropeptide Y receptor type 4-2 (sprot)

description: A protein that is a translation product of the NPY4R2 gene in human.


dimethyloxalylglycine

A glycine derivative that is the diester obtained by formal condensation of the carboxy groups of N-oxalylglycine with two molecules of methanol.


name: HMGN1_HUMAN Non-histone chromosomal protein HMG-14 (sprot)

description: A non-histone chromosomal protein HMG-14 that is encoded in the genome of human.


gadodiamide

A non-ionic gadolinium chelate having a macrocyclic triamine framework. It is used as a paramagnetic contrast agent in magnetic resonance imaging (MRI).


name: PAOX_HUMAN Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (sprot)

description: A peroxisomal N(1)-acetyl-spermine/spermidine oxidase that is encoded in the genome of human.


name: DHCR7_HUMAN 7-dehydrocholesterol reductase (sprot)

description: A 7-dehydrocholesterol reductase that is encoded in the genome of human.


name: PDGFD_HUMAN Platelet-derived growth factor D (sprot)

description: A platelet-derived growth factor D that is encoded in the genome of human.


name: K2C5_HUMAN Keratin, type II cytoskeletal 5 (sprot)

description: A keratin, type II cytoskeletal 5 that is encoded in the genome of human.


name: TNF13_HUMAN Tumor necrosis factor ligand superfamily member 13 (sprot)

description: A tumor necrosis factor ligand superfamily member 13 (human), isoforms alpha, beta, gamma, 4, and 5.


lanosterol

A tetracyclic triterpenoid that is lanosta-8,24-diene substituted by a beta-hydroxy group at the 3beta position. It is the compound from which all steroids are derived.


name: SGK3_HUMAN Serine/threonine-protein kinase Sgk3 (sprot)

description: A serine/threonine-protein kinase Sgk3 that is encoded in the genome of human.


name: TOM34_HUMAN Mitochondrial import receptor subunit TOM34 (sprot)

description: A mitochondrial import receptor subunit TOM34 that is encoded in the genome of human.


name: MBB1A_HUMAN Myb-binding protein 1A (sprot)

description: A Myb-binding protein 1A that is encoded in the genome of human.


name: PSB2_HUMAN Proteasome subunit beta type-2 (sprot)

description: A proteasome subunit beta type-2 that is encoded in the genome of human.


name: SCAP_HUMAN Sterol regulatory element-binding protein cleavage-activating protein (sprot)

description: A sterol regulatory element-binding protein cleavage-activating protein that is encoded in the genome of human.


name: PTN4_HUMAN Tyrosine-protein phosphatase non-receptor type 4 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 4 that is encoded in the genome of human.


PROF3_HUMAN Profilin-3 (sprot)

A profilin-3 that is encoded in the genome of human.


hantavirus pulmonary syndrome

description: An infection caused by Hantaviruses. It manifests with flu-like symptoms but it rapidly progresses to life-threatening respiratory problems.


name: GNT2A_HUMAN N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (sprot)

description: An N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase that is encoded in the genome of human.


B-cell acute lymphoblastic leukemia

description: A neoplasm of lymphoblasts committed to the B-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called B acute lymphoblastic leukemia. When it involves nodal or extranodal sites, it is called B lymphoblastic lymphoma. (WHO, 2001)


BRILLIANT GREEN

An iminium ion obtained by dimethylation of the imino group of 4-{[4-(dimethylamino)phenyl](phenyl)methylene}cyclohexa-2,5-dien-1-imine. Used in the form of its chloride salt as a green-coloured dye.


name: LSM2_HUMAN U6 snRNA-associated Sm-like protein LSm2 (sprot)

description: A U6 snRNA-associated Sm-like protein LSm2 that is encoded in the genome of human.


name: XRN2_HUMAN 5'-3' exoribonuclease 2 (sprot)

description: A 5'-3' exoribonuclease 2 that is encoded in the genome of human.


MAS_HUMAN Proto-oncogene Mas (sprot)

A G-protein coupled receptor MAS that is encoded in the genome of human.


Right ventricular hypertrophy

description: In this case the right ventricle is more muscular than normal, causing a characteristic boot-shaped (coeur-en-sabot) appearance as seen on anterior- posterior chest x-rays. Right ventricular hypertrophy is commonly associated with any form of right ventricular outflow obstruction or pulmonary hypertension, which may in turn owe its origin to left-sided disease. The echocardiographic signs are thickening of the anterior right ventricular wall and the septum. Cavity size is usually normal, or slightly enlarged. In many cases there is associated volume overload present due to tricuspid regurgitation, in the absence of this, septal motion is normal.


tiazofurine

A C-glycosyl compound that is 1,3-thiazole-4-carboxamide in which the hydrogen at position 2 has been replaced by a beta-D-ribofuranosyl group. It is metabolised to thiazole-4-carboxamide adenine dinucleotide (TAD), a selective inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase).


name: BRD2_HUMAN Bromodomain-containing protein 2 (sprot)

description: A bromodomain-containing protein 2 that is encoded in the genome of human.


MCE1_HUMAN mRNA-capping enzyme (sprot)

An mRNA-capping enzyme that is encoded in the genome of human.


name: RL5_HUMAN Large ribosomal subunit protein uL18 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL18 that is encoded in the genome of human.


PANX2_HUMAN Pannexin-2 (sprot)

A pannexin-2 that is encoded in the genome of human.


NAPSA_HUMAN Napsin-A (sprot)

A napsin-A that is encoded in the genome of human.


name: PO3F1_HUMAN POU domain, class 3, transcription factor 1 (sprot)

description: A POU domain, class 3, transcription factor 1 that is encoded in the genome of human.


anencephaly

description: A rare neural tube defect during pregnancy, resulting in the absence of a large portion of the brain and skull in the fetus.


name: immune reconstitution inflammatory syndrome

description: An inflammatory condition that arises after initiating antiretroviral therapy (ART) therapy in HIV-infected patients that results from restored immunity to specific infectious or non-infectious antigens.


name: HAX1_HUMAN HCLS1-associated protein X-1 (sprot)

description: An HCLS1-associated protein X-1 that is encoded in the genome of human.


female breast carcinoma

description: A carcinoma that arises from the breast in females. It is the most common malignant tumor that affects females.


SEM3E_HUMAN Semaphorin-3E (sprot)

A semaphorin-3E that is encoded in the genome of human.


name: DPYL3_HUMAN Dihydropyrimidinase-related protein 3 (sprot)

description: A dihydropyrimidinase-related protein 3 that is encoded in the genome of human.


secondary hyperparathyroidism

description: Overproduction of parathyroid hormone in response to influence external to the parathyroid glands.


name: MET16_HUMAN RNA N6-adenosine-methyltransferase METTL16 (sprot)

description: An RNA N6-adenosine-methyltransferase METTL16 that is encoded in the genome of human.


basal ganglia disorder

description: A disease involving the basal ganglia.


name: PIAS3_HUMAN E3 SUMO-protein ligase PIAS3 (sprot)

description: An E3 SUMO-protein ligase PIAS3 that is encoded in the genome of human.


name: FCG2B_HUMAN Low affinity immunoglobulin gamma Fc region receptor II-b (sprot)

description: A low affinity immunoglobulin gamma Fc region receptor II-b that is encoded in the genome of human.


kinetin

A member of the class of 6-aminopurines that is  adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group.


MYOTI_HUMAN Myotilin (sprot)

A myotilin that is encoded in the genome of human.


THYMOQUINONE

A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.


thiram

An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.


name: PPR1B_HUMAN Protein phosphatase 1 regulatory subunit 1B (sprot)

description: A protein phosphatase 1 regulatory subunit 1B that is encoded in the genome of human.


TYB4_HUMAN Thymosin beta-4 (sprot)

A thymosin beta-4 that is encoded in the genome of human.


name: SAFB1_HUMAN Scaffold attachment factor B1 (sprot)

description: A scaffold attachment factor B1 that is encoded in the genome of human.


mature cataract

description: A cataract that produces swelling and opacity of the entire lens; cataracts are removed before maturity.


anterior uveitis

description: Inflammation of the iris and anterior chamber of the eye.


TNMD_HUMAN Tenomodulin (sprot)

A tenomodulin that is encoded in the genome of human.


name: ORC5_HUMAN Origin recognition complex subunit 5 (sprot)

description: An origin recognition complex subunit 5 that is encoded in the genome of human.


name: RFX4_HUMAN Transcription factor RFX4 (sprot)

description: A transcription factor RFX4 that is encoded in the genome of human.


name: CP24A_HUMAN 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (sprot)

description: A 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial that is encoded in the genome of human.


membranous glomerulonephritis

description: A slowly progressive inflammation of the glomeruli characterized by immune complex deposits at the glomerular basement membrane, resulting in a thickened membrane, and nephrotic syndrome.


name: PIAS4_HUMAN E3 SUMO-protein ligase PIAS4 (sprot)

description: An E3 SUMO-protein ligase PIAS4 that is encoded in the genome of human.


phosphatidylcholine (O-16:0/18:1)

A 2-acyl-1-alkyl-sn-glycero-3-phosphocholine in which the acyl group contains 18 carbons and 1 double bond while the alkyl group contains 16 carbons and is fully saturated.


NITRIC ACID

A nitrogen oxoacid of formula HNO3 in which the nitrogen atom is bonded to a hydroxy group and by equivalent bonds to the remaining two oxygen atoms.


lupus vulgaris

description: A form of cutaneous tuberculosis. It is seen predominantly in women and typically involves the nasal mucosa; buccal mucosa; and conjunctival mucosa.


name: NOP58_HUMAN Nucleolar protein 58 (sprot)

description: A nucleolar protein 58 that is encoded in the genome of human.


name: ABC3D_HUMAN DNA dC->dU-editing enzyme APOBEC-3D (sprot)

description: A DNA dC->dU-editing enzyme APOBEC-3D that is encoded in the genome of human.


name: DVL3_HUMAN Segment polarity protein dishevelled homolog DVL-3 (sprot)

description: A segment polarity protein dishevelled DVL-3 that is encoded in the genome of human.


chronic periodontitis

description: A chronic inflammatory process that affects the tissues that surround and support the teeth.


name: RNF34_HUMAN E3 ubiquitin-protein ligase RNF34 (sprot)

description: An E3 ubiquitin-protein ligase RNF34 that is encoded in the genome of human.


name: SCP2_HUMAN Sterol carrier protein 2 (sprot)

description: A sterol carrier protein 2 that is encoded in the genome of human.


hemorrhagic cystitis

description: Inflammation of the bladder resulting in bloody urine.


name: ELOV1_HUMAN Very long chain fatty acid elongase 1 (sprot)

description: A very long chain fatty acid elongase 1 that is encoded in the genome of human.


name: VEGFC_HUMAN Vascular endothelial growth factor C (sprot)

description: A vascular endothelial growth factor C that is encoded in the genome of human.


name: ACVL1_HUMAN Serine/threonine-protein kinase receptor R3 (sprot)

description: A serine/threonine-protein kinase receptor R3 that is encoded in the genome of human.


name: SMAD5_HUMAN Mothers against decapentaplegic homolog 5 (sprot)

description: A smad5 that is encoded in the genome of human.


choriocarcinoma

description: An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected.


name: PTN12_HUMAN Tyrosine-protein phosphatase non-receptor type 12 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 12 that is encoded in the genome of human.


McCune-Albright syndrome

description: McCune-Albright syndrome (MAS) is classically defined by the clinical triad of fibrous dysplasia of bone (FD), cafe-au-lait skin spots, and precocious puberty (PP).


2-heptyl-4-hydroxyquinoline N-oxide

An inhibitor of the mitochondrial respiratory chain at cytochrome bc1 and of photosynthetic electron flow immediately before cytochrome b559.


name: PTSS1_HUMAN Phosphatidylserine synthase 1 (sprot)

description: A phosphatidylserine synthase 1 that is encoded in the genome of human.


bambuterol

A carbamate ester that is terbutaline in which both of the phenolic hydroxy groups have been protected as the corresponding N,N-dimethylcarbamates. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline.


sleep apnea syndrome

description: A disorder characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep.


goiter

description: Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing.


phosphatidylglycerol (18:3/16:0)

A phosphatidylglycerol 34:3 in which the 1- and 2-acyl groups are specified as octadecatrienoyl and hexadecanoyl respectively.


HELLP syndrome

description: A life-threatening condition that can potentially complicate pregnancy. It is named for 3 features of the condition: H emolysis, E levated L iver enzyme levels, and L ow P latelet levels. It typically occurs in the last 3 months of pregnancy (the third trimester) but can also start soon after delivery. A wide range of non-specific symptoms may be present in women with HELLP syndrome. Symptoms may include fatigue; malaise; fluid retention and excess weight gain; headache; nausea and vomiting; pain in the upper right or middle of the abdomen; blurry vision; and rarely, nosebleed or seizures. The cause of HELLP syndrome is not known, but certain risk factors have been associated with the condition. It is most common in women with preeclampsia or eclampsia. If not diagnosed and treated quickly, HELLP syndrome can lead to serious complications for the mother and baby.The main treatment is to deliver the baby as soon as possible, even if premature. Treatment may also include medications needed for the mother or baby, and blood transfusion for severe bleeding problems.


name: PAK2_HUMAN Serine/threonine-protein kinase PAK 2 (sprot)

description: A serine/threonine-protein kinase PAK 2 that is encoded in the genome of human.


autoimmune lymphoproliferative syndrome

description: Autoimmune lymphoproliferative syndrome (ALPS) is a rare, inherited disorder characterized by non-malignant lymphoproliferation, multilineage cytopenias, and a lifelong increased risk of Hodgkin's and non-Hodgkin's lymphoma.


name: KLF12_HUMAN Krueppel-like factor 12 (sprot)

description: A krueppel-like factor 12 that is encoded in the genome of human.


Wheezing

description: A high-pitched whistling sound associated with labored breathing.


name: RON_HUMAN Macrophage-stimulating protein receptor (sprot)

description: A macrophage-stimulating protein receptor that is encoded in the genome of human.


GPC3_HUMAN Glypican-3 (sprot)

A glypican-3 that is encoded in the genome of human.


name: CDC27_HUMAN Cell division cycle protein 27 homolog (sprot)

description: A cell division cycle protein 27 that is encoded in the genome of human.


MSGN1_HUMAN Mesogenin-1 (sprot)

A mesogenin-1 that is encoded in the genome of human.


name: UBP11_HUMAN Ubiquitin carboxyl-terminal hydrolase 11 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 11 that is encoded in the genome of human.


PYRIDOXAMINE

A monohydroxypyridine that is pyridine substituted by a hydroxy group at position 3, an aminomethyl group at position 4, a hydroxymethyl group at position 5 and a methyl group at position 2. The 4-aminomethyl form of vitamin B6, it is used (in the form of the hydrochloride salt) for treatment of diabetic nephropathy.


name: UNC4_HUMAN Homeobox protein unc-4 homolog (sprot)

description: A homeobox protein unc-4 that is encoded in the genome of human.


name: PDZ1I_HUMAN PDZK1-interacting protein 1 (sprot)

description: A PDZK1-interacting protein 1 that is encoded in the genome of human.


name: SPTN2_HUMAN Spectrin beta chain, non-erythrocytic 2 (sprot)

description: A spectrin beta chain, non-erythrocytic 2 that is encoded in the genome of human.


methoxsalen

A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.


larynx cancer

description: A primary or metastatic malignant neoplasm involving the larynx. The majority are carcinomas.


name: CNIH4_HUMAN Protein cornichon homolog 4 (sprot)

description: A protein cornichon homolog 4 that is encoded in the genome of human.


name: KCNQ2_HUMAN Potassium voltage-gated channel subfamily KQT member 2 (sprot)

description: A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of human.


A member of the class of phenols that is guaiacol in which the hydrogen para- to the hydroxy group is replaced by a vinyl group.


name: PLRG1_HUMAN Pleiotropic regulator 1 (sprot)

description: A pleiotropic regulator 1 that is encoded in the genome of human.


name: IOD3_HUMAN Thyroxine 5-deiodinase (sprot)

description: A thyroxine 5-deiodinase that is encoded in the genome of human.


name: MSI2H_HUMAN RNA-binding protein Musashi homolog 2 (sprot)

description: An RNA-binding protein Musashi homolog 2 that is encoded in the genome of human.


seliciclib

2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.


name: PAWR_HUMAN PRKC apoptosis WT1 regulator protein (sprot)

description: A PRKC apoptosis WT1 regulator protein that is encoded in the genome of human.


name: RHG26_HUMAN Rho GTPase-activating protein 26 (sprot)

description: A Rho GTPase-activating protein 26 that is encoded in the genome of human.


name: NPRL3_HUMAN GATOR1 complex protein NPRL3 (sprot)

description: A GATOR1 complex protein NPRL3 that is encoded in the genome of human.


name: SCN3A_HUMAN Sodium channel protein type 3 subunit alpha (sprot)

description: A sodium channel protein type 3 subunit alpha that is encoded in the genome of human.


central diabetes insipidus

description: Central diabetes insipidus (CDI) is a hypothalamus-pituitary disease characterized by polyuria and polydipsia due to a vasopressin (AVP) deficiency. It can be inherited or acquired (hereditary CDI and acquired CDI).


phosphatidylcholine (18:0/22:6)

A phosphatidylcholine 40:6 in which the fatty acyl groups at positions 1 and 2 are specified as C18:0 and C22:6 respectively.


lipomatosis

description: A neoplastic process characterized by diffuse overgrowth of mature adipose tissue.


polydatin

A stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue.


A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A naturally occurring flavonoid produced by several plants, including the weed Tridax procumbens (coalbuttons or tridax daisy) and the tree Godmania aesculifolia, In animal models, it has shown efficacy against several diseases of the nervous system, including Alzheimer's, Parkinson's, and Huntington's.


name: KI18B_HUMAN Kinesin-like protein KIF18B (sprot)

description: A kinesin-like protein KIF18B that is encoded in the genome of human.


name: SF3B4_HUMAN Splicing factor 3B subunit 4 (sprot)

description: A splicing factor 3B subunit 4 that is encoded in the genome of human.


name: DKK4_HUMAN Dickkopf-related protein 4 (sprot)

description: A dickkopf-related protein 4 that is encoded in the genome of human.


name: ECHA_HUMAN Trifunctional enzyme subunit alpha, mitochondrial (sprot)

description: A trifunctional enzyme subunit alpha, mitochondrial that is encoded in the genome of human.


long-chain fatty acid

A fatty acid with a chain length ranging from C13 to C22.


name: ELP1_HUMAN Elongator complex protein 1 (sprot)

description: An elongator complex protein 1 that is encoded in the genome of human.


name: FUT2_HUMAN Galactoside alpha-(1,2)-fucosyltransferase 2 (sprot)

description: A galactoside alpha-(1,2)-fucosyltransferase 2 that is encoded in the genome of human.


trichlormethiazide

A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension.


name: SAE2_HUMAN SUMO-activating enzyme subunit 2 (sprot)

description: A SUMO-activating enzyme subunit 2 that is encoded in the genome of human.


Epstein-Barr virus infection

description: An infection that is caused by Epstein-Barr virus.


name: rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome

description: A very rare disorder that appears after the first year and a half of life in previously healthy children. It is characterized by rapid-onset weight gain, hypothalamic dysfunction, breathing abnormalities, and autonomic system dysregulation. The hypothalamic dysfunction manifestations include inability to maintain normal water balance, high prolactin levels, low thyroid, low cortisol, and early or late puberty. The breathing abnormalities include sleep apnea and alveolar hypoventilation, requiring ventilation support. The autonomic system dysregulation includes eye abnormalities, intestinal abnormalities, temperature dysregulation, and low heart rhythm. This disorder requires early recognition because it may lead to cardiorespiratory arrest. Up to 40% of the patients develop tumors of neural crest origin.


name: ACM1_HUMAN Muscarinic acetylcholine receptor M1 (sprot)

description: A muscarinic acetylcholine receptor M1 that is encoded in the genome of human.


macitentan

A member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension.


name: STA10_HUMAN START domain-containing protein 10 (sprot)

description: A START domain-containing protein 10 that is encoded in the genome of human.


name: FCSD2_HUMAN F-BAR and double SH3 domains protein 2 (sprot)

description: An F-BAR and double SH3 domains protein 2 that is encoded in the genome of human.


hepatopulmonary syndrome

description: Hepatopulmonary syndrome (HPS) is a lung disease characterized by widening of arteries and veins (dilatation) in the lungs in people who have chronic liver disease. Because of the dilated vases, the workload of the heart increases and the blood pumped to the body does not have enough oxygen, leading to a decreased level of oxygen in the blood (hypoxemia). The normal diameter of the lung vessels ranges between 8 and 15 μm whereas when in HPS rises to between 15 and 500 μm. While many people with HPS don't have any obvious problems, the main reported symptom is shortness of breath (dyspnea) that is worse when standing or sitting up, and is relieved when lying down (platypnea). Symptoms related to chronic liver disease (generally cirrhosis) include small red spots on the skin (spider angiomas) and abnormal vascular dilatations. Some other symptoms that have been described are infections in the brain (brain abscesses), brain bleeding and an increased number of red blood cells in the blood (polycythemia). There is currently no effective medication for HPS. Oxygen therapy may improve the breathing in some cases. Liver transplant is an efficient treatment which improves the symptoms, even in severe cases.


erythema nodosum

description: A panniculitis that is characterized by sudden onset of painful, erythematous, subcutaneous nodules mainly localized to the pretibial areas. Lesions are usually bilateral and symmetrical, ranging from 1 to 5 cm in diameter.


name: VP37A_HUMAN Vacuolar protein sorting-associated protein 37A (sprot)

description: A vacuolar protein sorting-associated protein 37A that is encoded in the genome of human.


dequalinium

A quinolinium ion comprising decane in which one methyl hydrogen at each end of the molecule has been replaced by a 4-amino-2-methylquinolin-1-yl group.


name: OSTA_HUMAN Organic solute transporter subunit alpha (sprot)

description: An organic solute transporter subunit alpha that is encoded in the genome of human.


name: RHES_HUMAN GTP-binding protein Rhes (sprot)

description: A GTP-binding protein Rhes that is encoded in the genome of human.


A 1,2-di-octadecadienoyl-sn-glycero-3-phosphocholine in which the double bonds in each fatty acyl group are at positions 9 and 12 and have Z configuration.


ledipasvir

A benzimidazole derivative that is used in combination with sofosbuvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.


cryoglobulinemia

description: Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called 'cryoglobulins.' At cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. Many people affected by this condition will not experience any unusual signs or symptoms. When present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis ; joint or muscle pain; purpura ; Raynaud's phenomenon ; skin death; and/or skin ulcers. In some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease); and/or cancers of the blood or immune system. Treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause.


name: LIRB4_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 4 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily B member 4 that is encoded in the genome of human.


name: ABEC1_HUMAN C->U-editing enzyme APOBEC-1 (sprot)

description: A C->U-editing enzyme APOBEC-1 that is encoded in the genome of human.


TETRAHYDROPALMATINE

A berberine alkaloid obtained by formal addition of two molecules of hydrogen to the pyridine ring of palmatine.


name: ACD_HUMAN Adrenocortical dysplasia protein homolog (sprot)

description: An adrenocortical dysplasia protein that is encoded in the genome of human.


tolfenamic acid

An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.


(11Z)-icos-11-enoic acid

An icosenoic acid having a cis- double bond at position 11.


name: IF122_HUMAN Intraflagellar transport protein 122 homolog (sprot)

description: An intraflagellar transport protein 122 that is encoded in the genome of human.


iodixanol

A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.


sulfadoxine

A sulfonamide consisting of pyrimidine having methoxy substituents at the 5- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position. In combination with the antiprotozoal pyrimethamine (CHEBI:8673) it is used as an antimalarial.


name: PSD1_HUMAN PH and SEC7 domain-containing protein 1 (sprot)

description: A PH and SEC7 domain-containing protein 1 that is encoded in the genome of human.


name: BI2L1_HUMAN BAR/IMD domain-containing adapter protein 2-like 1 (sprot)

description: A brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 that is encoded in the genome of human.


name: DIM1_HUMAN Probable dimethyladenosine transferase (sprot)

description: A probable dimethyladenosine transferase that is encoded in the genome of human.


opsoclonus-myoclonus syndrome

description: Opsoclonus myoclonus syndrome (OMS) is a rare neuroinflammatory disease of paraneoplastic, parainfectious or idiopathic origin, characterized by opsoclonus, myoclonus, ataxia, and behavioral and sleep disorders.


inherited retinal dystrophy

description: An instance of retinal degeneration that is caused by an inherited modification of the individual's genome.


name: SRSF3_HUMAN Serine/arginine-rich splicing factor 3 (sprot)

description: A serine/arginine-rich splicing factor 3 that is encoded in the genome of human.


METHYSERGIDE

A synthetic ergot alkaloid, structurally related to the oxytocic agent methylergonovine and to the potent hallucinogen LSD and used prophylactically to reduce the frequency and intensity of severe vascular headaches.


Balkan nephropathy

description: A chronic tubulointerstitial nephropathy that affects people in certain rural areas along the Danube river in the Balkans. It leads to end-stage renal disease.


name: MRE11_HUMAN Double-strand break repair protein MRE11 (sprot)

description: A double-strand break repair protein MRE11 that is encoded in the genome of human.


name: DAB2P_HUMAN Disabled homolog 2-interacting protein (sprot)

description: A disabled homolog 2-interacting protein that is encoded in the genome of human.


name: FCRL4_HUMAN Fc receptor-like protein 4 (sprot)

description: An Fc receptor-like protein 4 that is encoded in the genome of human.


intestinal cancer

description: A malignant neoplasm involving the intestine


name: COT1_HUMAN COUP transcription factor 1 (sprot)

description: A COUP transcription factor 1 that is encoded in the genome of human.


name: RAB24_HUMAN Ras-related protein Rab-24 (sprot)

description: A Ras-related protein Rab-24 that is encoded in the genome of human.


nefopam

A racemate comprising equal amounts of (R)- and (S)-nefopam. The  hydrochloride is a centrally acting non-opiate analgesic commonly used for the treatment of moderate to severe pain.


name: nodular lymphocyte predominant Hodgkin lymphoma

description: A monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse proliferation of scattered large neoplastic cells known as popcorn or lymphocyte predominant cells (LP cells)- formerly called L&H cells for lymphocytic and/or histiocytic Reed-Sternberg cell variants. The LP cells lack CD15 and CD30 in nearly all instances. Patients are predominantly male, frequently in the 30-50 year age group. Most patients present with limited stage disease (localized peripheral lymphadenopathy, stage I or II). (WHO 2008)


name: CDKAL_HUMAN Threonylcarbamoyladenosine tRNA methylthiotransferase (sprot)

description: A threonylcarbamoyladenosine tRNA methylthiotransferase that is encoded in the genome of human.


name: BCLF1_HUMAN Bcl-2-associated transcription factor 1 (sprot)

description: A Bcl-2-associated transcription factor 1 that is encoded in the genome of human.


name: BCS1_HUMAN Mitochondrial chaperone BCS1 (sprot)

description: A mitochondrial chaperone BCS1 that is encoded in the genome of human.


name: MED31_HUMAN Mediator of RNA polymerase II transcription subunit 31 (sprot)

description: A mediator of RNA polymerase II transcription subunit 31 that is encoded in the genome of human.


Leigh syndrome

description: A progressive neurological disease defined by specific neuropathological features associating brainstem and basal ganglia lesions.


retinitis

description: Inflammation of the retina.


name: NEK6_HUMAN Serine/threonine-protein kinase Nek6 (sprot)

description: A serine/threonine-protein kinase Nek6 that is encoded in the genome of human.


name: PLS4_HUMAN Phospholipid scramblase 4 (sprot)

description: A phospholipid scramblase 4 that is encoded in the genome of human.


FZD4_HUMAN Frizzled-4 (sprot)

A frizzled-4 that is encoded in the genome of human.


name: KAP3_HUMAN cAMP-dependent protein kinase type II-beta regulatory subunit (sprot)

description: A cAMP-dependent protein kinase type II-beta regulatory subunit that is encoded in the genome of human.


advanced sleep phase syndrome

description: A very rare circadian rhythm sleep disorder characterized by very early sleep onset and offset possibly resulting in emotional and physical disruptions.


name: SFR19_HUMAN Splicing factor, arginine/serine-rich 19 (sprot)

description: A splicing factor, arginine/serine-rich 19 that is encoded in the genome of human.