name: Testicular Sertoli Cell Tumor, Lipid Rich Variant

description: A testicular Sertoli cell tumor in which the neoplastic cells have clear and vacuolated cytoplasm due to accumulation of intracytoplasmic lipids.


Endometrial Dedifferentiated Carcinoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A carcinoma that arises from the endometrium and is characterized by the presence of an undifferentiated carcinomatous component and a second component of either FIGO grade 1 or 2 endometrioid carcinoma.


Adult Type Granulosa Cell Tumor

description: A low-grade malignant sex cord-stromal tumor occurring in the ovary and rarely in the testis. It is composed of granulosa cells in an often fibrothecomatous stroma. The neoplastic cells may form various patterns including the microfollicular, which is characterized by the presence of Call-Exner bodies, macrofollicular, insular, trabecular, and diffuse pattern. In females, it affects middle aged to post-menopausal women. Signs and symptoms include abdominal mass, hemoperitoneum, and ascites. Estrogenic and rarely androgenic manifestations may be present. The vast majority of cases present as stage I tumors; however, all tumors have a potential for aggressive clinical course. In males, it is reported in the age range of 16-76 years and the average age at presentation is 44 years. A minority of patients have gynecomastia. Metastases have been reported in a minority of patients.


Stage IA2 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 3 mm and not more than 5 mm in depth. (FIGO 2009)


A1 Hydronephrosis

description: Antenatal hydronephrosis with the following clinical findings: 1) an anterior-posterior renal pelvis diameter (APRPD) of 4 to less than 7 mm at less than 28 weeks, 2) to less than10 mm at greater than or equal to 28 weeks, and 3) may have central calyceal dilation. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


name: Childhood Benign Genitourinary System Neoplasm

description: A childhood neoplasm that arises from any part of the genitourinary system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Invasive Lipid-Rich Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by the presence of lipid laden tumor cells.


Sickle Cell-SS Disease

description: A variant of sickle cell disease due to homozygosity of the E6V mutation, amino acid substitution of valine for glutamic acid in the sixth position of the beta chain, resulting in the production of hemoglobin S from both alleles.


Steroid-induced myopathy

description: A non-neoplastic disorder affecting the skeletal muscles. It is caused by damage to muscle fibers either by excessive intake of corticosteroids (steroid treatment) or high levels of endogenous corticosteroids due to hormonal abnormalities. Patients usually present with weakness mainly in the proximal muscles of the upper and lower extremities and the neck flexors.


Neonatal Early-Onset Sepsis

description: An infectious disorder of newborn infants that is characterized by a systemic inflammatory response within 72 hours of life and is most commonly caused by bacteria.


Rheumatic aortic valve disease

description: A disorder of the aortic valve secondary to rheumatic fever.


Refractory Cervical Carcinoma

description: Cervical carcinoma that is resistant to treatment.


name: Intrahepatic Bile Duct Biliary Intraepithelial Neoplasia

description: A neoplastic, non-invasive lesion that affects the intrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


46,XY Sex Reversal 2

description: Sex reversal in an individual with 46,XY karyotype caused by point mutations or deletions in the NR0B1 gene, encoding nuclear receptor subfamily 0 group B member 1.


name: Idiopathic 46,XY Differences of Sex Development

description: Conditions affecting individuals whose karyotype is 46,XY that is characterized by atypical development of the internal or external sex structures, or the gonads, and in whom no genetic, environmental, or biochemical causation can be established.


name: Stage IIB Ampulla of Vater Cancer AJCC v7

description: Stage IIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  T2: Tumor invades the duodenal wall.  T3: Tumor invades the pancreas.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Islet Glucagon Cell Hyperplasia

description: Hyperplasia of the alpha cells of the pancreas.


Malignant neoplasm of urethra local

description: A urethral carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Unresectable Pancreatic Neuroendocrine Carcinoma

description: Pancreatic neuroendocrine carcinoma that is not amenable to surgical resection.


Mucosal Melanoma of the Urinary System

description: A malignant melanocytic neoplasm that arises from a mucosal site of the urinary system.


Exogenous Obesity

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Obesity caused by caloric intake greater than caloric expenditures.


Biventricular congestive heart failure

description: Heart failure due to dysfunction of both the left and right ventricles.


name: Recurrent Extracranial Malignant Solid Neoplasm

description: The reemergence of an extracranial malignant solid neoplasm after a period of remission.


name: Aleukemic Acute Lymphoblastic Leukemia Cutis

description: Aleukemic acute lymphoblastic leukemia that manifests with cutaneous involvement.


HPV16 Infection

description: An infection caused by human papillomavirus 16. HPV16 infection is associated with a risk for cervical cancer.


Hemangioma of conjunctiva

description: A hemangioma that arises from the conjunctiva.


Exertional Fatigue

description: Prolonged, extreme exhaustion after physical or mental effort or stress.


Refractory Gallbladder Carcinoma

description: Gallbladder carcinoma that is resistant to treatment.


Ileal Fistula

description: An abnormal communication between the ileum and another organ or cavity.


Vulvar Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the vulva. Representative examples include infection and fibroepithelial polyp.


External hydrocephalus

description: Abnormal increase of cerebrospinal fluid in the subdural space of the brain.


description: A Hodgkin lymphoma that develops in patients who are immunosuppressed with methotrexate.


name: Advanced Extrapulmonary Neuroendocrine Carcinoma

description: Extrapulmonary neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Esophageal Large Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus.  It is characterized by the presence of malignant large cells.


Recurrent Subsequent Malignant Neoplasm

description: The reemergence of a malignant neoplasm other than the original one, after a period of remission.


Eye Melanocytoma

description: A benign neoplastic melanocytic proliferation affecting the optic disk and optic nerve or the uvea.


name: Human Papillomavirus-Related Cervical Carcinoma

description: A carcinoma that arises from the cervix and is caused by human papillomavirus infection.


Stage IV Uterine Corpus Cancer AJCC v6

description: Stage IV includes: IVA: (T4, Any N, M0); IVB: (Any T, Any N, M1).  T4: Tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4).  M1: Distant metastasis (includes metastasis to abdominal lymph nodes other than para-aortic, and/or inguinal lymph nodes: excludes metastasis to vagina, pelvic serosa, or adnexa). (AJCC 6th ed.)


Oligometastatic Gastric Adenocarcinoma

description: Gastric adenocarcinoma that has metastasized to a limited number of sites.


Stage IB Vulvar Carcinoma AJCC v6

description: Stage IB includes: T1b, N0, M0.  T1ab Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension, and with stromal invasion greater than 1mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


name: Appendix Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of an appendiceal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to appendiceal NETs (carcinoid tumors) (NET G1 and G2, and rare well-differentiated G3). High-grade neuroendocrine carcinomas (NEC), goblet cell carcinoids, mixed adenocarcinomas, and adenocarcinomas of the appendix are not staged using this staging system. (from AJCC 8th Ed.)


Breast Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm arising from the breast.


MGMT-Methylated Glioblastoma

description: A glioblastoma characterized by the presence of DNA methylation in the promoter region of the MGMT gene. It is associated with improved survival.


Stage III Skin Cancer

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor with invasion of maxilla, mandible, orbit, or temporal bone.  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th Ed.)


Mental Retardation, X-linked 21/34

description: An X-linked recessive condition caused by mutation(s) in the IL1RAPL1 gene, encoding interleukin-1 receptor accessory protein-like 1. It is characterized by intellectual disability ranging from moderate mental retardation to high-functioning autism.


name: Endometrial Endometrioid Adenocarcinoma with a Poorly Differentiated Carcinomatous Component

description: A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of a component with poorly differentiated carcinoma cells.


Stage I Gallbladder Cancer AJCC v6

description: Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0). T1: Tumor invades lamina propria or muscle layer.  T1a: Tumor invades lamina propria.  T1b: Tumor invades muscle layer.  N0: No regional metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


name: Recurrent Fallopian Tube Transitional Cell Carcinoma

description: The reemergence of fallopian tube transitional cell carcinoma after a period of remission.


name: Stage IIIB Cervical Cancer AJCC v6 and v7

description: Stage IIIB includes: (T3b, Any N, M0); (T1-3, N1, M0).  T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non-functioning kidney. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Malignant melanoma, regressing

description: A skin lesion characterized by the disappearance of the melanoma cells from the primary melanoma site. The disappearance of the malignant cells is associated with fibroplasia of the papillary dermis. According to some authors, complete regression of the primary melanoma may occur in 4-8% of patients.


Foreign body embolism

description: Occlusion of a lumen by a foreign object.


Lentigo simplex

description: The most common form of the skin disorder lentigo, characterized by a single or multiple benign, pigmented macules of unknown etiology that are present at birth or develop in early childhood.


name: Hodgkin's disease nodular sclerosis stage II subdiaphragmatic


name: Stage 0 Cutaneous Melanoma AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Melanoma in situ.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


Refractory Myeloid Neoplasm

description: A myeloid neoplasm that does not respond to treatment.


Stage IV Bladder Cancer AJCC v6

description: Stage IV includes the following: T4b, N0, M0; Any T, N1, M0; Any T, N2 M0; Any T, N3 M0; Any T, Any N, M1.  T4b: Tumor invades the pelvic wall, abdominal wall.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension.  M1: Distant metastasis.  (AJCC 6th Ed.)


Intestinal nematode infection

description: An infection in the gastrointestinal tract by a nematode.


Stage IIA Anal Cancer AJCC v8

description: Stage IIA includes: T2, N0, M0. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Treatment related secondary malignancy

description: The development of a malignant neoplasm in response to medical or surgical treatment, induced by the treatment itself.


name: Anal Extramucosal (Perianal) Adenocarcinoma

description: An anal adenocarcinoma arising from the lining of an anorectal fistulous tract or the anal glands.  The overlying anal mucosa does not show evidence of neoplastic changes.  It usually presents as a submucosal tumor.


Trichogerminoma

description: A rare subtype of trichoblastoma characterized by the presence of lobules of basaloid cells. The lobules are separated by fibrous stroma. It is associated with the expression of recurrent FOXK1/GRHL and GPS2/GRHL gene fusions.


name: Childhood Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A

description: An acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A occurring in children.


name: Stage IV Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Diffuse or disseminated (multifocal) involvement of one or more extra-lymphatic organs with or without associated lymph node involvement or isolated (non-contiguous) extra-lymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s) or any involvement of liver, bone marrow, lungs (except by direct extension from another site) or CSF. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Locally Advanced Neuroendocrine Tumor

description: A neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Tracheal Mucositis

description: An inflammatory process affecting the mucous membrane of the trachea.


name: Lugano Classification Stage II Bulky Adult Hodgkin Lymphoma AJCC v8

description: Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


name: Acute Myeloid Leukemia with a Variant MECOM Rearrangement

description: A term referring to acute myeloid leukemias with rearrangement of the MECOM gene with various genes other than the GATA2 gene.


Cystic Periventricular Leukomalacia

description: Necrosis and softening of the white matter around the ventricles in the brain associated with cystic changes.


Hamartoma of Mature Cardiac Myocytes

description: A non-malignant, focal growth in the heart, composed of unencapsulated nodules of enlarged, hypertrophic, mature cardiac myocytes with a variable amount of collagen and fat.


Prosoposchisis

description: A congenital anatomic defect characterised by a facial cleft that extends from the mouth to the orbit of the eye.


name: Advanced Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that has spread extensively from its original site of growth to other anatomic sites or is no longer responding to treatment.


Disorder of soft tissue

description: A non-neoplastic or neoplastic disorder that affects the soft tissue.


Sporadic Retinoblastoma

description: A retinoblastoma that occurs in a patient without a family history of the disease.


Recurrent Acute Leukemia

description: The reemergence of acute leukemia after a period of remission.


Locally Advanced Angiosarcoma

description: An angiosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Intracystic papillary neoplasm with low grade intraepithelial neoplasia

description: An intracholecystic papillary neoplasm that arises from the epithelium of the gallbladder. It is characterized by the presence of mild epithelial atypia.


name: Stage I Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Tumor is limited to the kidney and completely excised. Renal capsule intact, not penetrated by tumor. No tumor invasion of veins or lymphatics of renal sinus. No nodal or hematogenous metastases. No prior biopsy. Negative margins. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Recurrent Myeloid Neoplasm

description: The reemergence of a myeloid neoplasm after a period of remission.


Pansclerotic Morphea

description: A rare, aggressive form of morphea characterized by sclerosis of the dermis, fascia, and muscle over large parts of the body, resulting in contractures and immobility.


Endocrine Therapy-Induced Alopecia

description: Alopecia caused by treatment with endocrine therapy agents.


name: Transplant-Related Skin Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the skin in a patient with a history of organ transplantation.


name: Radiating Chest Pain Along Right Midclavicular Line

description: The location of the radiating chest pain is along the right midclavicular line.


name: Female Non-Neoplastic Reproductive System Disorder

description: A non-neoplastic disorder that affects the female reproductive system. Representative examples include endometriosis, pelvic inflammatory disease, and endometritis.


Neonatal Late-Onset Sepsis

description: An infectious disorder of newborn infants that is characterized by a systemic inflammatory response beyond 72 hours of life and is most commonly caused by bacteria.


Recurrent Pancreatic Cystadenocarcinoma

description: The reemergence of pancreatic cystadenocarcinoma after a period of remission.


lipoma of bone

description: A benign neoplasm which is composed of adipocytes and arises from the surface of the bone or the medullary cavity.


Extrapulmonary Neuroendocrine Carcinoma

description: A small or large cell neuroendocrine carcinoma that arises from an anatomic site other than the lung.


Prostate Myeloid Sarcoma

description: Myeloid sarcoma that affects the prostate gland.  It may present in association with or as a site of relapse of acute myeloid leukemia.  Cases of myeloid sarcoma of the prostate gland preceding acute myeloid leukemia have also been reported.


name: Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm

description: Blastic plasmacytoid dendritic cell neoplasm that is resistant to treatment.


Locally Advanced Gastric Carcinoma

description: A gastric carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Vulvar Melanocytic Neoplasm

description: A neoplasm that originates from melanocytes and arises from the vulva. This category includes congenital and acquired melanocytic nevus, blue nevus, dysplastic melanocytic nevus, atypical melanocytic nevus of genital type, and melanoma.


Cocaine dependence, continuous

description: Physical or psychological dependence on the drug cocaine which is associated with a pattern of continuous use.


Recurrent Adult Hodgkin Lymphoma

description: The reemergence of Hodgkin lymphoma in adulthood after a period of remission.


Classical Poroma

description: A poroma characterized by the presence of cords and aggregates of neoplastic cells in the superficial dermis in connection with the epidermis.


Environment-Related Malignant Neoplasm

description: Cancers caused by exposure to carcinogens in the general environment


Moist Desquamation

description: A skin reaction characterized by sloughing of the epidermis and serous exudate.


Incidental Gallbladder Carcinoma

description: Gallbladder carcinoma that is discovered incidental to gallbladder surgery for another indication.


Advanced Esophageal Carcinoma

description: Esophageal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage II Prostate Cancer AJCC v8

description: Stage II includes: IIA: (cT1a-c, cT2a, N0, M0, PSA equal or more than 10 and less than 20, Grade Group 1); (cT2b-c, N0, M0, PSA less than 20, Grade Group 1); IIB: T1-2, N0, M0, PSA less than 20, Grade Group 2; IIC: (T1-2, N0, M0, PSA less than 20, Grade Group 3); (T1-2, N0, M0, PSA less than 20, Grade Group 4). cT1a: Prostate cancer in which the tumor is an incidental histologic finding in 5% or less of tissue resected. cT1b: Prostate cancer in which the tumor is an incidental histologic finding in more than 5% of tissue resected. cT1c: Prostate cancer in which the tumor is identified by needle biopsy found in one or both sides, but not palpable. cT2a: Prostate cancer in which the tumor involves one-half of one side or less. cT2b: Prostate cancer in which the tumor involves more than one-half of one side but not both sides. cT2c: Prostate cancer in which the tumor involves both sides. T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


name: Childhood Retinoblastoma by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood retinoblastoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


Childhood Liver Neoplasm

description: A benign or malignant neoplasm that affects the liver and occurs during childhood.


Physical Examination Finding

description: The result of an evaluation of the body and its functions using visual inspection, palpation, percussion, or auscultation that is performed to determine the presence, absence, or degree of a condition.


Radiating Pain

description: A sensation of discomfort or distress that spreads from one anatomic location to another.


name: Metastatic Bladder Large Cell Neuroendocrine Carcinoma

description: Bladder large cell neuroendocrine carcinoma that has spread to another anatomical site.


Metastatic ocular melanoma

description: Ocular melanoma that has spread from its original site of growth to another anatomic site.


Cortical Cataract Grade 4

description: A stage of cortical cataract characterized by greater than 90% of the intrapupillary space obscured by opacity. (Modified LOCS II)


name: Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8

description: Stage IIA includes: T1, N1, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Low Grade Biliary Intraepithelial Neoplasia

description: Biliary intraepithelial neoplasia characterized by the presence of low grade epithelial dysplasia.


Gallbladder Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the gallbladder. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


name: H-type congenital tracheoesophageal fistula

description: Congenital tracheoesophageal fistula without esophageal atresia.


Testicular Typical Seminoma

description: A testicular seminoma characterized by the presence of uniform round germ cells with glycogen-rich cytoplasm and large nuclei, and a lymphocytic infiltrate.


name: Non-Neoplastic Connective and Soft Tissue Disorder

description: A non-neoplastic disorder that affects the connective and soft tissue.


Peritoneal Pain

description: Painful sensation in the peritoneum.


Neoplasm by Morphology

description: A classification system grouping neoplasms according to their cellular characteristics.


name: Recurrent Platinum-Resistant Fallopian Tube High Grade Serous Adenocarcinoma

description: The reemergence of platinum-resistant fallopian tube high-grade serous adenocarcinoma after a period of remission.


Bladder cancer stage IV

description: A carcinoma that arises from the bladder and has metastasized to another anatomic site.


name: High Grade Mucinous Carcinoma Peritonei with Signet Ring Cells

description: A high-grade mucinous adenocarcinoma that has spread to the peritoneum and is characterized by the presence of signet ring malignant cells.


Bladder Melanoma

description: A rare melanoma that arises from the bladder mucosa.


Extranodal Lymphoma

description: A non-Hodgkin or Hodgkin lymphoma that arises from an anatomic site other than a lymph node.


Non-Neoplastic Bladder Disorder

description: A non-neoplastic disorder that affects the urinary bladder. Representative examples include cystitis, cystolithiasis, and urinary bladder rupture.


Stage IIIB Appendix Carcinoma AJCC v8

description: Stage IIIB includes: (T3, N1, M0); (T4, N1, M0). T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4: Tumor invades the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or mesoappendix, and/or directly invades adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. M0: No distant metastasis. (AJCC 8th ed.)


name: Ampulla of Vater Intestinal-Type Adenocarcinoma

description: An invasive adenocarcinoma arising from the ampulla of Vater. Morphologically, it is characterized by the presence of intestinal-type malignant epithelial cells.


name: Refractory T/NK-Cell Lymphoproliferative Disorder

description: T/NK-cell lymphoproliferative disorder that is resistant to treatment.


Acute Myeloid Leukemia with STAT3-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of STAT3-RARA fusion protein.


Diffuse hyperplasia

description: Hyperplasia characterized by the presence of a diffuse cellular infiltrate.


Chronic Cancer Pain

description: Chronic pain that results from cancer and/or its treatment. The mechanism for chronic cancer pain may be  inflammatory, neuropathic, ischemic, and/or mechanical in nature.


carcinoma of urinary tract

description: A carcinoma that arises from the organs that comprise the urinary tract. This category includes renal pelvis carcinoma, ureter carcinoma, bladder carcinoma, urethral carcinoma, urothelial carcinoma, adenocarcinoma of the urinary tract, clear cell adenocarcinoma of the urinary tract, diverticular carcinoma of the urinary tract, endometrioid adenocarcinoma of the urinary tract, and squamous cell carcinoma of the urinary tract.


Squamous cell carcinoma, microinvasive

description: A squamous cell carcinoma with minimal stromal invasion.


name: Childhood Retinoblastoma by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood retinoblastoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


name: Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage III includes: (T2, N1, M0); (T3, N0-1, M0); (T4a, N0-1, M0). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IIIA includes: T0-2, N1, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Enteropathic arthritis

description: A form of chronic arthritis that is found in some patients with inflammatory bowel disease.


Cervical Cancer by FIGO Stage 2018

description: A term that refers to the staging of cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging, 2018.


AIDS-Related Malignant Anal Neoplasm

description: A malignant neoplasm arising from the anus and occurring in HIV-positive patients.  Representative examples include squamous cell carcinoma and non-Hodgkin lymphoma.  Homosexual HIV-positive men have an increased risk of developing such malignancies in comparison to the general male population.


Refractory Malignant Endocrine Neoplasm

description: Malignant endocrine neoplasm that is resistant to treatment.


name: Refractory Post-Essential Thrombocythemia Myelofibrosis

description: Post-essential thrombocythemia myelofibrosis that is resistant to treatment.


Adenocarcinoma with metaplasia

description: An adenocarcinoma characterized by the presence of metaplasia.


Testis cancer recurrent

description: Malignant testicular germ cell tumor reemerging after a period of remission.


name: Low Grade Cervical Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic process that affects the cervical squamous epithelium without evidence of invasion. It is usually associated with human papillomavirus infection. It is characterized by the presence of mild atypia in the superficial epithelial layer that may be associated with koilocytosis. Maturation is present in the upper two thirds of the epithelium. Mitotic figures are not numerous and are present in the basal third of the epithelium.


Cyclitis

description: Inflammation of the ciliary body.


Pseudoangiomatous stromal hyperplasia

description: A benign proliferation of the stromal cells in the breast.  It is classified as simple, when associated with the presence of slit-like spaces without erythrocytes and as fascicular/proliferative, when spindle cell proliferation without atypia is present.  It is often seen in breast tissue specimens as small foci associated with benign epithelial lesions.  Pseudoangiomatous stromal hyperplasia presenting as a well-circumscribed palpable mass is rare.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 1

description: Dyskeratosis congenita caused by autosomal recessive mutation(s) in the NOP10 gene, encoding H/ACA ribonucleoprotein complex subunit 3.


Unresectable Malignant Solid Neoplasm

description: A malignant solid neoplasm that is not amenable to surgical resection.


Crushing Pain

description: A sense of discomfort or distress that is squeezing or excessively compressing.


Bladder Neuroendocrine Tumor

description: A well-differentiated neuroendocrine neoplasm arising from the bladder. It is characterized by the presence of uniform cells with stippled chromatin and inconspicuous nucleoli. Mitotic activity is low and tumor necrosis is absent.


Stage I Prostate Cancer AJCC v8

description: Stage I includes: (cT1a-c, cT2a, N0, M0, PSA less than 10, Grade Group 1); (pT2, N0, M0, PSA less than 10, Grade Group 1). cT1a: Prostate cancer in which the tumor is an incidental histologic finding in 5% or less of tissue resected. cT1b: Prostate cancer in which the tumor is an incidental histologic finding in more than 5% of tissue resected. cT1c: Prostate cancer in which the tumor is identified by needle biopsy found in one or both sides, but not palpable. cT2a: Prostate cancer in which the tumor involves one-half of one side or less. pT2: Prostate cancer which is organ confined. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. (AJCC 8th ed.)


name: Unresectable Gastroesophageal Junction Adenocarcinoma

description: Gastroesophageal junction adenocarcinoma that is not amenable to surgical resection.


Recurrent Anaplastic Ependymoma

description: The reemergence of anaplastic ependymoma after a period of remission.


description: The presence of bacteria in the blood caused by an infected hemodialysis catheter.


Metastatic Carcinoma in the Pancreas

description: A carcinoma that has spread to the pancreas from another anatomic site.


Refractory Low Grade Astrocytoma

description: Low grade astrocytoma that is resistant to treatment.


name: Stage IV Renal Pelvis and Ureter Cancer AJCC v8

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat. N0: No regional lymph node metastasis. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm in greatest dimension; or multiple lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Ampulla of Vater Neuroendocrine Tumor

description: A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and periampullary region.


name: Posterior Fossa Ependymoma, Not Otherwise Specified

description: A circumscribed ependymoma that arises in the posterior fossa in which molecular analysis for DNA methylation profiling was unsuccessful or not reported.


name: Locally Advanced Prostate Adenocarcinoma

description: A prostatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Metastases to abdominal cavity

description: The spread of a malignant neoplasm from a primary site to an unspecified organ in the abdominal cavity.


Conjunctival Oncocytoma

description: A benign epithelial neoplasm that arises from the conjunctiva. It is characterized by the presence of oncocytic cells with abundant eosinophilic and granular cytoplasm.


Advanced Malignant Skin Neoplasm

description: A malignant neoplasm of the skin that has spread extensively to other anatomic sites or is no longer responding to treatment.


Pancreatic Alpha Cell Adenoma

description: A benign endocrine neoplasm arising from the alpha cells of the pancreas.  It produces glucagon.


name: Lugano Classification Advanced Stage Hodgkin Lymphoma AJCC v8

description: Advanced stage Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


name: Stage IIA Ampulla of Vater Cancer AJCC v8

description: Stage IIA includes: T3a, N0, M0. T3a: Tumor directly invading the pancreas (up to 0.5 cm). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IVB Vulvar Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (including pelvic lymph node metastasis). (from AJCC 8th Ed.)


name: Stage III Lentigo Maligna Melanoma AJCC v7

description: Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Reproductive Endocrine Neoplasm

description: A benign or malignant endocrine neoplasm that arises from the testis or the ovary.


Anemia due to Decreased Production

description: Anemia that results from a decreased rate of erythropoiesis.


name: Melanoma Metastatic in the Central Nervous System

description: A melanoma that has spread to the central nervous system from its original site of growth, through the hematogenous route.


Childhood Aneurysmal Bone Cyst

description: An aneurysmal bone cyst that occurs during childhood.


Stage IB Vulvar Cancer AJCC v8

description: Stage IB includes: T1b, N0, M0. T1b: Lesion measuring more than 2 cm, or any size with stromal invasion of more than 1.0 mm, confined to the vulva and/or perineum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Pancreatic Cancer AJCC v8

description: Stage IIA includes: T3, N0, M0. T3: Tumor measuring more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Clonal Hematopoiesis of Indeterminate Potential

description: A term that refers to the presence of somatic mutations in bone marrow or peripheral blood cells in individuals who may be cytopenic but do not have morphologic evidence of hematologic neoplasia. Its prevalence rises with age and is found in approximately 10% of individuals aged 70 to 80. It is associated with an increased risk of hematologic neoplasia. Mutations in the DNMT3A, TET2, or ASXL1 genes are usually identified. Approximately 10%-40% of individuals with age-related clonal hematopoiesis will progress to meet the diagnostic criteria for clonal hematopoiesis of indeterminate potential.


Refractory Fibrosarcoma

description: Fibrosarcoma that is resistant to treatment.


Metastatic Melanoma in the Skin

description: A melanoma that has spread to the skin from a cutaneous or extracutaneous primary site.


Substance-Induced Anxiety Disorder

description: An anxiety disorder in which the symptoms of anxiety have been determined to be etiologically related to the direct physiological effects of a substance (i.e., a drug of abuse, a medication, or toxin exposure).


name: Clinical Stage I Esophageal Adenocarcinoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IIIC Fallopian Tube Cancer AJCC v8

description: Stage IIIC includes: T3c, N0/N1, M0. T3c: Fallopian tube cancer with macroscopic peritoneal metastasis beyond the pelvis more than 2 cm in greatest dimension with or without metastasis to the retroperitoneal lymph nodes (includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ). N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Vascular hemorrhagic disorders

description: A hemorrhagic disorder that is caused by pathologic changes in the vasculature.


Pregnancy Mood Swing

description: The fluctuations in the mental and emotional state of an individual during pregnancy.


Peripheral Vascular Insufficiency

description: A condition in which there is inadequate blood flow through the peripheral blood vessels due to intrinsic disease of the vasculature.


name: Amnestic disorders due to a general medical condition

description: A disorder involving memory impairment (either anterograde or retrograde) that is etiologically linked to the direct physiological consequence of a general medical condition. The memory impairment is not the result of a delirium or dementia.


name: Advanced Gastric Small Cell Neuroendocrine Carcinoma

description: A gastric small cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Subdural Hemorrhage Related to Birth

description: Bleeding within the subdural space occurring during labor and/or delivery.


name: Metastatic Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: Extrapulmonary small cell neuroendocrine carcinoma that has spread to another anatomic site.


name: Pancreatic Mucinous-Cystic Neoplasm, Low Grade

description: A non-invasive mucinous cystic neoplasm that arises from the pancreas and is characterized by the presence of mild dysplasia and absence of mitotic figures.


name: Hereditary coagulation factor deficiency

description: An inherited blood coagulation disorder characterized by deficiency of one of the coagulation factors, resulting in bleeding.


Cytomegalovirus End-Organ Disease

description: Tissue-invasive cytomegalovirus infection, typically seen in solid-organ transplant recipients.


Myelofibrosis due to another disorder

description: Myelofibrosis that develops in patients with a history of hematologic malignancies or toxic injury to the bone marrow.


Neuropathic Pain

description: Chronic pain caused by damage to nerve fibers.  It is usually associated with tissue injury.


name: Prostate Ductal Adenocarcinoma, Papillary Pattern

description: A prostate ductal adenocarcinoma characterized by the presence of a papillary growth pattern.


name: Pathologic Stage 0 Esophageal Adenocarcinoma AJCC v8

description: Stage 0 includes: Tis, N0, M0, GN/A. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. GN/A: Grade non-applicable. (AJCC 8th ed.)


Early Favorable Hodgkin Lymphoma

description: An early Hodgkin lymphoma with favorable prognosis.


Stage IV Prostate Cancer AJCC v8

description: Stage IV includes: IVA: Any T, N1, M0, PSA: Any, Grade Group: Any; IVB: Any T, N0, M1, PSA: Any, Grade Group: Any. N0: Prostate cancer with no positive regional nodes. N1: Prostate cancer with metastases in regional node(s). M0: Prostate cancer without evidence of distant metastasis. M1: Prostate cancer with distant metastasis. (AJCC 8th ed.)


Hemorrhage

description: The flow of blood from a ruptured blood vessel.


name: Monoclonal Paraproteinemia Present in Lower than Myeloma Levels

description: An indication that the detected amount of monocolonal paraproteinemia in a sample is lower than the range of levels that are associated with myeloma.


name: Human immunodeficiency virus leukoencephalopathy


Childhood Kidney Disorder

description: A kidney disorder that appears during childhood.


Inflammation

description: A finding of a localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation.


Emotional problems

description: A perceived issue with a person's emotional wellbeing.


name: Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IVA includes: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


High-CSD Melanoma

description: A cutaneous melanoma that develops on sun-exposed sites with a high degree of cumulative sun damage (CSD).


Recurrent Malignant Endocrine Neoplasm

description: Reemergence of a malignant endocrine neoplasm after a period of remission.


name: Anemia due to disorders of nucleotide metabolism

description: A group of hemolytic anemias that result from either the deficiency or overproduction of several enzymes involved in metabolizing nucleotides.


Metastatic Neuroendocrine Tumor

description: A neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


name: Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma by AJCC v8 Stage

description: A term that refers to the staging of adrenal gland pheochromocytoma and sympathetic paraganglioma, following the rules of the TNM AJCC v8 classification system. Parasympathetic paragangliomas are not staged because they are largely benign. This staging system does not apply to neuroendocrine tumors of the pancreas (are staged according to the classification for neuroendocrine tumors of the pancreas) and carotid body tumors (not staged). (from AJCC 8th Ed.)


Recurrent Retinoblastoma

description: The reemergence of retinoblastoma after a period of remission.


Invasive Malignant Neoplasm

description: Cancer that has spread beyond the layer of tissue in which it developed and is growing into surrounding, healthy tissues.


name: Chronic Myelomonocytic Leukemia with Eosinophilia

description: A chronic myelomonocytic leukemia characterized by a peripheral blood eosinophil count of equal or greater than 1.5x10E9/L, and absence of PDGFRA or PDGFRB gene abnormalities.


name: Advanced Platinum-Resistant Malignant Germ Cell Tumor

description: A platinum-resistant malignant germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage IIIB Fallopian Tube Cancer AJCC v8

description: Stage IIIB includes: T3b, N0/N1, M0. T3b: Fallopian tube cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


name: Ampulla of Vater Invasive Papillary Adenocarcinoma

description: An invasive adenocarcinoma that arises from an exophytic papillary neoplasm of the ampulla of Vater.


Stage IVC Appendix Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1b, Any G.  M1b: Nonperitoneal metastasis.  (AJCC 7th ed.)


name: Unresectable Bladder Small Cell Neuroendocrine Carcinoma

description: Bladder small cell neuroendocrine carcinoma that is not amenable to surgical resection.


Repeat Expansion Disease

description: A class of genetic diseases that occur when microsatellite repeats expand beyond a threshold length.


name: Anal Adenocarcinoma within Anorectal Fistula

description: An anal adenocarcinoma arising from the lining of an anorectal fistulous tract.  The overlying anal mucosa does not show evidence of neoplastic changes.  Some cases are associated with Crohn disease.


name: idiopathic normal pressure hydrocephalus

description: A disorder characterized by hydrocephalus in the setting of normal cerebrospinal fluid pressure, gait apraxia, impaired cognition and urinary urgency or incontinence.


Lyme Arthritis

description: Joint inflammation, most often affecting large joints, associated with Lyme disease, presenting months after infection.


Stage IA Cutaneous Melanoma AJCC v7

description: Stage IA includes: T1a, N0, M0.  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and with mitosis less than 1/mm2.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


name: Stage IA Fallopian Tube Cancer AJCC v6 and v7

description: Stage IA includes: T1a, N0, M0. T1a: Tumor limited to one tube, without penetrating the serosal surface; no ascites.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Benign Infratentorial Neoplasms

description: A neoplasm that arises from the infratentorial region and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Acute Lymphoblastic Leukemia by Gene Expression Profile

description: Gene expression-based patient cluster groups in acute lymphoblastic leukemia.


Composite paraganglioma

description: A neoplasm that combines morphologic characteristics of paraganglioma and neuroectodermal tumors such as neuroblastoma, ganglioneuroma, ganglioneuroblastoma, or peripheral nerve sheath tumor.


Recurrent pyogenic cholangitis

description: A recurrent form of cholangitis that is characterized by intrabiliary pigment stone formation, biliary tree stricture and obstruction, and recurrent bouts of cholangitis. There is an association with biliary parasitosis, but evidence supporting these infections in the pathogenesis of recurrent pyogenic cholangitis is inconclusive. The most common causes of death are sepsis, liver failure, or complications from cirrhosis. Patients are also at increased risk of cholangiocarcinoma.


name: Stage II Ampulla of Vater Cancer AJCC v8

description: Stage II includes: IIA: T3a, N0, M0; IIB: T3b, N0, M0. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Bone lesion

description: A localized pathological or traumatic structural change, damage, deformity, or discontinuity of bone.


name: Germinative Follicular Epithelium Neoplasm

description: A neoplasm involving the germinative follicular epithelium.


name: Infectious disease of genitourinary system

description: An acute or chronic infectious process affecting any part of the genitourinary system.


name: Myeloid/Lymphoid Neoplasms with ETV6-ABL1

description: Hematologic neoplasms characterized by t(9;12)(q34.1;p13.2) that results in ETV6-ABL1 gene fusion. They have clinicopathological features of chronic myeloid leukemia with frequent eosinophilia.


Mixed Failure to Thrive

description: Failure to thrive due to both organic and non-organic causes.


name: Childhood Malignant Digestive System Neoplasm

description: A malignant neoplasm that affects any part of the digestive system and occurs during childhood.


name: Stage IV Lentigo Maligna Melanoma AJCC v6 and v7

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (from AJCC 6th and 7th Eds.)


Pediatric Infectious Disorder

description: An infectious disorder that occurs during infancy, childhood, or adolescence.


Hypothalamic Cancer

description: A primary or metastatic malignant neoplasm that affects the hypothalamus.


Hypergranular promyelocytic leukemia

description: Acute Promyelocytic leukemia characterized by the presence of hypergranular promyelocytes and characteristic cells that contain bundles of Auer rods.


Stage IVB Gallbladder Cancer AJCC v8

description: Stage IVB includes: (Any T, N2, M0); (Any T, Any N, M1). N2: Metastases to four or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Locally Advanced Bladder Small Cell Neuroendocrine Carcinoma

description: A bladder small cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Primary cutaneous CD30 antigen positive T-cell lymphoproliferative disorder

description: A spectrum of lymphoproliferative disorders characterized by CD30 (Ki-1)-positive cutaneous T-cell infiltrates. The two ends of the spectrum include lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma.


Dyspnea with Moderate Physical Activity

description: Dyspnea experienced during moderate exertion.


name: Localized Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: An undifferentiated high grade pleomorphic sarcoma of bone that occurs in childhood and has not spread to other anatomic sites.


name: Locally Advanced Pancreatic Neuroendocrine Carcinoma

description: A pancreatic neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Unresectable Oligodendroglioma

description: An oligodendroglioma that is not amenable to surgical resection.


name: Stage IA Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of a single lymph node region or involvement of a single extra-lymphatic organ or site, without lymph node involvement. No constitutional symptoms are recorded. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Yolk Sac Tumor with Somatic-Type Malignancy

description: A yolk sac tumor that is characterized by morphologic transformation to somatic-type malignancy. The somatic-type malignant component most often is sarcomatous or carcinomatous.


name: Clear Cell Tumor with Melanocytic Differentiation and MITF-CREM Translocation

description: A MITF pathway-activated melanocytic tumor characterized by a cytogenetic translocation between MITF and CREM genes that results in MITF-CREM gene fusion. It presents as a single non-pigmented cutaneous nodule in the distal extremities. It is composed of large cells with clear cytoplasm that exhibit melanocytic differentiation and proliferate in the dermis without an intraepidermal component. Extension in the subcutaneous tissue is frequently seen. The neoplastic cells exhibit atypical features, including nuclear enlargement and hyperchromasia, irregular nuclear borders, and enlarged nucleolus. Mitotic activity is prominent. The biologic potential of this tumor is unknown.


Intraepithelial Melanocytic Hyperplasia

description: A hyperplasia of the intraepithelial melanocytes.


Childhood Gastric Carcinoma

description: A rare carcinoma of the stomach that occurs during childhood.


Stage IV Gallbladder Cancer AJCC v6

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.)


name: Stage y-I Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Tumor limited to kidney and completely resected. Renal capsule may be infiltrated by tumor, but tumor does not reach the outer surface. Tumor may protrude or bulge into the pelvic system or ureter but does not infiltrate. Vessel of renal sinus not involved. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Native valve endocarditis

description: Endocarditis affecting a native valve of the heart.


Benign germ cell neoplasm

description: A germ cell tumor without evidence of atypia and metastatic potential.


Pleural Infection

description: An infectious process affecting the pleura.


Stage II Uterine Corpus Cancer

description: Stage II includes: T2, N0, M0.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  Endocervical glandular involvement only should be considered as Stage I and not as Stage II.  N0: No regional lymph node metastasis. M0: No distant metastasis.  This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Esophageal Hodgkin Lymphoma

description: A very rare Hodgkin lymphoma that arises from the esophagus.


Refractory Vaginal Carcinoma

description: Vaginal carcinoma that does not respond to treatment.


Verumontanum Mucosal Gland Hyperplasia

description: A benign microacinar proliferation occurring exclusively in the verumontanum and adjacent posterior urethra where the ejaculatory ducts and utricle empty into the urethra. Crystalloids and intraluminal mucin are usually absent, but; intraluminal corpora amylacea are often present. The lining epithelium typically consists of bland cuboidal to columnar luminal cells with underlying basal cells.


name: Unresectable Fallopian Tube Endometrioid Adenocarcinoma

description: Fallopian tube endometrioid adenocarcinoma that is not amenable to surgical resection.


name: Acute Myeloid Leukemia with t(1;17)(q42.3;q21.2); IRF2BP2-RARA

description: Acute myeloid leukemia with variant RARA rearrangement associated with t(1;17)(q42.3;q21.2) resulting in IRF2BP2-RARA fusion protein expression.


Benign Anal Granular Cell Tumor

description: A granular cell tumor that arises from the anus and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Acquired Facial Nerve Palsy

description: A condition characterized by reduced or absent movement of the ipsilateral face as a consequence of an injury to the seventh cranial nerve that has occurred after birth.


Unresectable Fibrosarcoma

description: A fibrosarcoma that is not amenable to surgical resection.


name: Beta Thalassemia Plus Structural Variants

description: A heterozygous state in which a person has a mutation in a beta globin allele causing beta thalassemia, together with other structural variants in the other allele.


Esthesioneurocytoma

description: A rare benign neuroectodermal tumor originating from olfactory receptor cells in the nasal cavity. Microscopically, it is characterized by the absence of malignant characteristics and the absence of rosettes formation.


Recurrent Primary Amyloidosis

description: The reemergence of primary amyloidosis after a period of remission.


Metastatic urothelial carcinoma

description: A carcinoma that arises from the urothelium and has spread from its original site of growth to another anatomic site.


Metastatic transitional cell carcinoma

description: A carcinoma that arises from transitional cells and has spread from its original site of growth to another anatomic site.


name: Localized Childhood Malignant Bone Neoplasm by Toronto Guidelines v2

description: Tumor confined to the area of origin including the regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Non-Neoplastic Peritoneal Disorder

description: A non-neoplastic disorder that affects the peritoneum. Representative examples include peritonitis and panniculitis.


Inherited neuropathies

description: A hereditary disorder that affects the sensory and/or motor nerves or the autonomic nerves.


name: Pathologic Stage IIIA Merkel Cell Carcinoma AJCC v8

description: Stage IIIA includes: (T1-4, N1a(sn) or N1a, M0); (T0, N1b, M0). T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1a(sn): Clinically occult regional lymph node metastasis identified only by sentinel lymph node biopsy. N1a: Clinically occult regional lymph node metastasis following lymph node dissection. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Esophageal Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The Ki-67 index is higher than 20%.


Advanced Malignant Germ Cell Tumor

description: A malignant germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Endometrial Carcinoma

description: Endometrial carcinoma that is not amenable to surgical resection.


Aplastic anemia due to infection

description: Aplastic anemia caused by an infection.


name: Schizoaffective disorder, depressive type

description: Schizoaffective disorder with episodes of depression only.


name: Esophageal High Grade Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal mucosa.  It includes lesions termed moderate dysplasia, and carcinoma in situ (severe dysplasia).  (WHO, 2000)


name: Advanced Primary Malignant Brain Neoplasm

description: A malignant neoplasm that arises from the brain and has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage IIIB Fallopian Tube Cancer AJCC v7

description: Stage IIIB includes: T3b, N0, M0.  T3b: Macroscopic peritoneal metastasis outside the pelvis 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Pathologic Stage I Esophageal Adenocarcinoma AJCC v8

description: Stage I includes: IA: (T1a, N0, M0, G1); (T1a, N0, M0, GX); IB: (T1a, N0, M0, G2); (T1b, N0, M0, G1-2); (T1b, N0, M0, GX); IC: (T1, N0, M0, G3); (T2, N0, M0, G1-2). T1a: Tumor invades the lamina propria or muscularis mucosae. T1b: Tumor invades the submucosa. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. G2: Moderately differentiated. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Neoplasm by Special Category

description: A neoplasm defined by its unique characteristic as they apply to clinical presentation and course, morphologic patterns, frequency, and/or age distribution.


Localized Gastric Carcinoma

description: A carcinoma that arises from the stomach and has not spread to other anatomic sites.


Uterine Ligament Wolffian Tumor

description: An epithelial neoplasm of Wolffian (mesonephric) origin arising from a uterine ligament. Most tumors behave in a benign fashion.


Transient Hyperinsulinism

description: Hyperinsulinism that resolves spontaneously. This is the most common cause of neonatal hypoglycemia.


Recurrent Malignant Solid Neoplasm

description: A malignant solid neoplasm that has recurred after a period of remission.


Chronic Decubitus

description: A longstanding lesion caused by death of tissue due to external pressure.


Sinusoidal hemangioma

description: A rare hemangioma occurring mainly in middle-aged adults. The most common location is in the trunk. The lesions are small, asymptomatic, and bluish. They are composed of irregular, dilated, congested thin-walled vascular channels with scant smooth muscle in a sinusoidal or sieve-like pattern. (WHO 2018)


Stage IB Cervical Cancer AJCC v9

description: Stage IB includes: T1b, N0, M0. T1b: Tumor with measured deepest invasion more than 5 mm (greater than FIGO stage IA); lesion limited to the cervix uteri with size measured by maximum tumor diameter. Note: The involvement of vascular/lymphatic spaces should not change the staging. The lateral extent of the lesion is no longer considered. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Verruca Plana

description: A wart characterized by the presence of flat-topped cutaneous papules. It is caused by human papillomavirus. It most commonly affects children and usually arises on the face, hands, and shins.


Macular Rash

description: An outbreak of small, flat, red spots on the skin.


name: Stage IVB Cervical Cancer AJCC v6 and v7

description: Stage IVB includes: Any T, Any N, MI. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Stage IIIC Gastric Cancer AJCC v7

description: Stage IIIC includes: (T4b, N2, M0); (T4b, N3, M0); (T4a, N3, M0).  T4a: Tumor invades serosa (visceral peritoneum).  T4b: Tumor invades adjacent structures. N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Killing Pain

description: A sensation of extreme discomfort and anguish that is perceived as severe enough to cause one's death.


name: Metastatic Pancreatic Ductal Adenocarcinoma

description: An adenocarcinoma that arises from the exocrine pancreatic ducts and has metastasized to other anatomic sites.


Bilateral cataracts (disorder)

description: Partial or complete opacity of the crystalline lens of both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.)


name: Hematologic Malignancy-Associated Skin Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the skin in a patient with a history of hematologic malignancy, usually non-Hodgkin lymphoma or chronic lymphocytic leukemia.


Marginal ulcer

description: An ulcer that develops in the jejunal mucosa close to the anastomosis site following a gastroenterostomy procedure.


name: Metastatic Carcinoma to the Uterine Cervix

description: A carcinoma that has spread to the cervix from another anatomic site.


description: A high grade poorly differentiated carcinoma arising from the digestive system.  It is composed of small or large neoplastic cells that express immunohistochemical evidence of neuroendocrine differentiation.  There is marked nuclear atypia, necrosis, and more than 20 mitoses per 10 HPF.


Nevus of Female Genitalia

description: A nevus that arises from the female genital organs. This category includes congenital nevus, acquired nevus, dysplastic nevus, blue nevus, and atypical melanocytic nevus of the genital type.


Pseudoporphyria

description: A drug-induced photodermatosis characterized by skin fragility, erythema, and the appearance of tense bullae, erosions and scarring in the absence of abnormalities in porphyrin metabolism.


name: Acute Myocardial Injury with Type I Myocardial Infarction Related to COVID-19

description: Acute myocardial injury with clinical presentation suggestive of type I myocardial infarction with detection of a rise or fall of cardiac troponin values with at least one value above the 99th percentile upper reference limit and with at least 1 of the following: 1. Symptoms of acute myocardial ischemia; 2. New ischemic ECG changes; 3. Development of pathological Q waves; 4. Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischemic etiology; 5. Identification of a coronary thrombus by angiography including intracoronary imaging or by autopsy, occurring in a patient with probable or confirmed acute COVID-19.


description: Intraepithelial neoplasia of the penis or vulva. It usually presents as a solitary white or pink macule or plaque that may be slightly elevated. A background of long-standing lichen sclerosus is often present.


Oral Pain

description: Painful sensation in the mouth, tongue, or lips.


Ectromelia

description: A congenital defect characterized by the absence or hypoplasia of one or more extremities.


Acute Bacterial Prostatitis

description: An acute infection of the prostate gland caused by bacteria, most often Escherichia coli, Proteus mirabilis, Klebsiella, and Pseudomonas aeruginosa. Signs and symptoms include fever, lower back pain, urinary frequency, and painful urination.  The urinalysis reveals the presence of white cells.  Risk factors include intraprostatic ductal reflux, phimosis, urinary tract infections, and unprotected anal intercourse.


name: Stage IIIC1 Uterine Corpus Cancer AJCC v8

description: Stage IIIC1 includes: T1-T3, N1/N1mi/N1a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N1: Regional lymph node metastasis to pelvic lymph nodes. N1mi: Regional lymph node metastasis (greater than 0.2 mm but nor greater than 2.0 mm in diameter) to pelvic lymph nodes. N1a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to pelvic lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Refractory Malignant Neoplasm of Multiple Primary Sites

description: Malignant neoplasm of multiple primary sites that is resistant to treatment.


Urethral Melanoma

description: A rare melanoma that arises from the urethral mucosa.


name: Refractory Invasive Pulmonary Aspergillosis

description: Invasive pulmonary aspergillosis that is resistant to treatment.


Skin Nodulocystic Basal Cell Carcinoma

description: A nodular basal cell carcinoma composed of solid and cystic areas.


Thoracotomy Scar

description: Replacement of destroyed tissue by fibrous tissue due to a surgical procedure where an incision was made into the chest wall to the left or to the right of the midline.


P2 Hydronephrosis

description: Postnatal Hydronephrosis with the following clinical findings: 1) APRPD is greater than or equal to 15 mm, 2) the calyces may be dilated centrally and peripherally, 3) or a dilated ureter is visible, 4) the parenchymal thickness and appearance is normal, and 5) the bladder is normal. Cases in which there is peripheral calyceal dilation but the APRPD is less than 15 mm are classified as UTD P2. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


name: Prostatic Intraepithelial Neoplasia-Like Adenocarcinoma

description: A rare subtype of prostate acinar adenocarcinoma that morphologically resembles high-grade prostatic intraepithelial neoplasia. It is characterized by the presence of large malignant glands lined with pseudostratified epithelium. It is graded as Gleason score 3+3=6.


name: Resectable Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that is amenable to surgical resection.


name: Stage I Gastric Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Cervical Mesonephric Remnants and Hyperplasia

description: The presence of embryonic remnants of mesonephric ducts in the cervix and their benign hyperplastic proliferations.


Glucagonoma, malignant

description: A glucagon-producing neuroendocrine tumor arising from the alpha cells of the pancreas.  It may be associated with necrolytic erythema migrans, diarrhea, diabetes, glossitis, weight loss, malabsorption, and anemia.  It displays vascular invasion and metastasizes to other anatomic sites.


name: Benign Osteoclastic Giant Cell-Rich Tumor of Bone

description: A giant cell tumor that arises from the bone and is characterized by the absence of local aggression and lack of metastatic potential.


name: Unresectable Pancreatic Ductal Adenocarcinoma

description: Pancreatic ductal adenocarcinoma that is not amenable to surgical resection.


Recurrent Acute Myeloid Leukemia

description: The reemergence of acute myeloid leukemia after a period of remission.


Recurrent Plasma Cell Neoplasm

description: The reemergence of a plasma cell neoplasm after a period of remission.


Prostate Paraganglioma

description: A paraganglioma that affects the prostate gland.


name: Adenoma of the Retinal Pigment Epithelium

description: A benign neoplasm that arises from the retinal pigment epithelium. It consists of cords and tubules of variably pigmented proliferating retinal pigment epithelium cells, separated by fibrous stroma. Malignant transformation is rare. (WHO 2018)


Neonatal Herpes Simplex Infection

description: Infection in the first month of life caused by the Herpes simplex virus.


name: Low Grade Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth.


Leukemia, Myeloid, Chronic-Phase

description: A phase of chronic myeloid leukemia, BCR-ABL1 positive in which the peripheral blood smear shows leukocytosis with neutrophils in different stages of maturation, less than 2% blasts, and normal or increased platelet count. Most patients have mild anemia. The bone marrow is hypercellular due to increased numbers of neutrophils and their precursors, and blasts usually account for fewer than 5% of the marrow cells. Megakaryocytes are smaller than normal and have hypolobated nuclei. The spleen is enlarged due to infiltration of the cords of the red pulp by granulocytes.


Neuroendocrine carcinoma of the bladder

description: A malignant, high grade neuroendocrine neoplasm that arises from the bladder. This category includes small cell and large cell neuroendocrine carcinoma.


Drug Resistant Epilepsy

description: Epilepsy that is refractory to treatment.


name: Stage IIIC Esophageal Adenocarcinoma AJCC v7

description: Stage IIIC includes: (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Recurrent WHO Grade 3 Glioma

description: The reemergence of a WHO grade III glioma after a period of remission.


Advanced Adenoid Cystic Carcinoma

description: Adenoid cystic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Lacrimal Drainage System Lymphoepithelial Carcinoma

description: A rare nonkeratinizing squamous cell carcinoma that arises from the lacrimal sac or nasolacrimal duct. It is characterized by the presence of large cells with vesicular nuclei and prominent nucleoli, a syncytial growth pattern, and a lymphoplasmacytic infiltrate.


Thrombosis of abdominal aorta

description: Formation of blood clot in the lumen of the abdominal aorta. It may lead to severe abdominal pain and ischemic necrosis of the intestine.


Stage IIIA Cervical Cancer FIGO 2018

description: Cervical carcinoma that involves the lower third of the vagina, with no extension to the pelvic wall. (FIGO 2018)


Acquired factor IX deficiency disease

description: An acquired coagulation disorder characterized by the partial or complete absence of factor IX activity in the blood.


name: Refractory Fallopian Tube Adenocarcinoma

description: Fallopian tube adenocarcinoma that is resistant to treatment.


name: Recurrent Pineal Parenchymal Cell Neoplasm

description: The reemergence of pineal parenchymal cell neoplasm after a period of remission.


FNCLCC Sarcoma Grade 3

description: A sarcoma with a total score of 6 or higher according to the FNCLCC guidelines.


name: Male Reproductive System Precancerous Condition

description: A premalignant pathologic process arising from an organ of the male reproductive system.  It is characterized by cellular atypia and/or dysplasia but does not show morphologic evidence of stromal invasion at the time of diagnosis.  Representative examples include prostatic intraepithelial neoplasia, giant condyloma acuminatum of the penis, and penile intraepithelial neoplasia.


name: Unresectable Ampulla of Vater Adenocarcinoma

description: Adenocarcinoma that arises from the ampulla of Vater and is not amenable to surgical resection.


Metastatic Bone Sarcoma

description: Bone sarcoma that has spread from the original site of growth to another anatomic site.


name: Hyperplasia of Brunner glands of duodenum

description: A rare hyperplastic lesion of Brunner's gland in the duodenum. Although it is usually asymptomatic and discovered incidentally during upper gastrointestinal endoscopy, it may cause hemorrhage.


name: B-Cell Proliferation of Uncertain Malignant Potential

description: A B-cell lymphoproliferative disorder with uncertain malignant potential. The representative example of this category is lymphomatoid granulomatosis.


Refractory Vulvar Carcinoma

description: Vulvar carcinoma that does not respond to treatment.


Foreign-Body Reaction

description: An inflammatory lesion comprised of epithelioid histiocytes and chronic inflammation that is caused by the presence of extraneous material.


Non-Neoplastic Musculoskeletal Disorder

description: A non-neoplastic disorder that affects muscles and bones.


lymphomatoid papulosis, type C

description: A variant of lymphomatoid papulosis characterized clinically by regressing skin papules, and morphologically by features resembling anaplastic large cell lymphoma.


description: Ovarian or testicular dysfunction associated with high levels of gonadotropins, that is present at birth.


name: Chronic Phase Chronic Myeloid Leukemia, Philadelphia Chromosome Positive, BCR-ABL1 Positive

description: A phase of chronic myeloid leukemia, Philadelphia chromosome positive, BCR-ABL1 positive in which the peripheral blood smear shows leukocytosis with neutrophils in different stages of maturation, less than 2% blasts, and normal or increased platelet count. Most patients have mild anemia. The bone marrow is hypercellular due to increased numbers of neutrophils and their precursors, and blasts usually account for fewer than 5% of the marrow cells. Megakaryocytes are smaller than normal and have hypolobated nuclei. The spleen is enlarged due to infiltration of the cords of the red pulp by granulocytes.


name: Recurrent Ampulla of Vater Adenocarcinoma

description: The reemergence of ampulla of Vater adenocarcinoma after a period of remission.


Congenital Cystic Hygroma

description: A congenital lymphatic malformation usually arising from the neck and characterized by cystic dilation of the lymphatic vessels.


Adenocarcinoma endometrial metastatic

description: An adenocarcinoma which originated in the endometrium and has spread to another anatomic site.


Seminal Versicle Carcinoma

description: A carcinoma that arises from the seminal vesicle.


name: Refractory Acute Myeloid Leukemia Not Otherwise Specified

description: Acute myeloid leukemia not otherwise specified that does not respond to treatment.


name: Recurrent Monomorphic Post-Transplant Lymphoproliferative Disorder

description: The reemergence of monomorphic post-transplant lymphoproliferative disorder after a period of remission.


description: An exceedingly rare adenocarcinoma that arises from the endometrium and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage.


Stage IB Gastric Carcinoma

description: Stage IB includes: (T2, N0, M0); (T1, N1, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


description: An alveolar rhabdomyosarcoma characterized by the absence of chromosomal translocation t(1;13)(p36;q14) or t(2;13)(q35;q14) and therefore the absence of PAX7-FOXO1 or PAX3-FOXO1 gene fusion.


Primary Malignant Pelvic Neoplasm

description: A malignant neoplasm that arises from the organs and structures of the pelvis.


Severe Cardiac Valve Regurgitation

description: Evidence of severe retrograde blood flow through the valve(s) of the heart. (ACC)


name: FIGO Grade 1 Endometrial Mucinous Adenocarcinoma

description: A primary mucinous adenocarcinoma of the endometrium that contains equal to or less than 5% non-squamous solid areas.


name: Mixed Cellularity Classic Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for mixed cellularity classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Junctional Spitz Nevus

description: A Spitz nevus characterized by the presence of a junctional melanocytic component without involvement of the dermis.


Stage III Urethral Cancer AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0); (T3, N1, M0). T1: For male penile urethra and female urethra: Tumor invades subepithelial connective tissue. For prostatic urethra: Tumor invades urethral subepithelial connective tissue immediately underlying the urothelium. T2: For male penile urethra and female urethra: Tumor invades any of the following: corpus spongiosum, periurethral muscle. For prostatic urethra: Tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts. T3: For male penile urethra and female urethra: Tumor invades any of the following: corpus cavernosum, anterior vagina. For prostatic urethra: Tumor invades the periprostatic fat. N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIA Appendix Carcinoma AJCC v8

description: Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. M0: No distant metastasis. (AJCC 8th ed.)


name: clear cell adenocarcinoma of gallbladder

description: A rare morphologic variant of gallbladder adenocarcinoma composed of malignant glandular epithelium with a predominance of glycogen rich clear cells.  The cells display hyperchromic nuclei and well-defined cytoplasmic borders.


Fetal Neurodevelopmental Disorder

description: A fetal affliction that has a neurological basis and manifests as a developmental disability.


Miserable Pain

description: A sensation of discomfort or distress that renders an individual unable to find any happiness.


Stage I Vulvar Cancer

description: Stage I includes: T1, N0, M0. T1: Invasive vulvar cancer confined to the vulva or perineum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: T-Cell Large Granular Lymphocyte Leukemia Expressing the T-Cell Receptor Gamma-Delta

description: An uncommon variant of T-cell large granular lymphocyte leukemia expressing the gamma-delta T-cell receptor. Approximately 60% of these cases are CD8-positive and the remainder are CD4/CD8-negative.


Unresectable Low Grade Glioma

description: Low grade glioma that is not amenable to surgical removal.


Stage III Bone Cancer AJCC v8

description: Stage III includes: T3, N0, M0, G2 or G3. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


name: Radiating Chest Pain Along Right Middle Sternal Border

description: The location of the radiating chest pain is along the right middle sternal border.


Nevoid Melanoma

description: A rare variant of cutaneous melanoma occurring mostly in adults in their fifth decade. Morphologically it resembles an ordinary compound or dermal nevus.


Stage I Bone Cancer AJCC v7

description: Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Metastatic malignant neoplasm to retina

description: A malignant neoplasm that has spread to the retina from another anatomic site.


Stage IVB Uterine Corpus Cancer AJCC v7

description: Stage IVB includes: Any T, Any N, M1.  M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, or lung, liver, or bone.  It excludes metastasis to para-aortic lymph nodes, vagina, pelvic serosa, or adnexa). This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Stage IB3 Cervical Cancer FIGO 2018

description: Invasive cervical carcinoma equal or more than 4 cm in greatest dimension. (FIGO 2018)


Cutaneous Mature B-Cell Neoplasm

description: A mature B-cell neoplasm that affects the skin.


Prostate Melanoma

description: An exceptionally rare melanoma arising from the prostate gland.


Deep Lipoma

description: A benign well-circumscribed tumor, composed of mature adipocytes, that arises within deep soft tissues.


Craniofacial Fibrous Dysplasia

description: Fibrous dysplasia affecting the craniofacial bones.


Cardiac granuloma

description: A granuloma located in the myocardium.


name: Stage III Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Residual tumor or nonhematogenous metastases confined to abdomen. Involved abdominal nodes. Peritoneal contamination or tumor implant. Tumor spillage of any degree occurring before or during surgery. Gross residual tumor in abdomen. Biopsy of tumor (including fine-needle aspiration) prior to removal of kidney. Resection margins involved by tumor. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage IIA Esophagus Carcinoma

description: Stage IIA includes: For squamous cell carcinoma: (T2-3, N0, M0, G1, GX, Tumor location: Upper, middle); (T2-3, N0, M0, G2-3, Tumor location: Lower, X).  For adenocarcinoma: (T2, N0, M0, G3).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Leukopenia neonatal

description: Leukopenia that occurs in the neonatal period.


Acute lymphoblastic leukemia recurrent

description: The reemergence of acute lymphoblastic leukemia after a period of remission.


name: Unresectable Small Cell Neuroendocrine Carcinoma

description: Small cell neuroendocrine carcinoma that is not amenable to surgical resection.


Pancreatic intraepithelial neoplasia

description: A pre-cancerous, non-invasive pancreatic epithelial neoplasm that arises from and is confined to the pancreatic ducts.  It is a papillary or flat neoplasm that usually measures less than 5 mm in diameter.


Esophageal Cancer by AJCC v8 Stage

description: A term that refers to the staging of esophageal carcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Stage IIIB Merkel Cell Carcinoma AJCC v7

description: Stage IIIB includes: Any T, N1b/N2, M0.  N1b: Macrometastasis in regional lymph nodes.  N2: In transit metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Recurrent Myeloproliferative Neoplasm

description: The reemergence of a myeloproliferative neoplasm after a period of remission.


Sexual Aversion Disorder

description: A disorder characterized by recurrent or persistent extreme aversion to, and avoidance of, all genital contact with a sexual partner. The aversion to sexual contact is not attributable to another psychiatric disorder.


Gallbladder Tubular Carcinoid

description: A neuroendocrine tumor that arises from the gallbladder.  It does not show the morphologic characteristics of typical carcinoid tumors (neoplastic cells forming solid nests). In contrast, the tumor cells form small discrete tubules.


name: Cutaneous Melanoma by AJCC v8 Clinical Stage

description: A term that refers to the clinical staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system.


Childhood Osteoid Osteoma

description: An osteoid osteoma that occurs during childhood.


Stage IA Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring equal or less than 5 mm in depth and equal or less than 7 mm in width. (FIGO 2009)


Primary Valvular Disorder

description: Heart disease that is primarily due to a valvular defect or abnormality. Valve disease that is felt to be significant but does not fulfill the definition for primary valvular heat disease is considered contributory valvular heart disease.


Merkel Cell Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v7 classification system.


name: Childhood Benign Nervous System Neoplasm

description: A childhood neoplasm that arises from the nervous system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Thrombosis of vena cava

description: The formation of a thrombus in the vena cava.


name: Pelvic Undifferentiated High Grade Pleomorphic Sarcoma

description: Undifferentiated high grade pleomorphic sarcoma  involving the bones of the pelvis.


Marasmic kwashiorkor

description: Evidence of marasmic kwashiorkor.


Chronic Orthostatic Intolerance

description: A condition in which there is orthostatic intolerance lasting for at least three months with associated functional impairment. (ACC/AHA)


Renal hemangioma

description: A rare hemangioma arising from the kidney.


name: FIGO Grade 2 Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma exhibiting 6-50% solid non-glandular, non-squamous growth.


name: Recurrent Malignant Urinary System Neoplasm

description: Reemergence of a malignant urinary system neoplasm after a period of remission.


name: Stage I Esophageal Adenocarcinoma AJCC v7

description: Stage I includes: IA (T1, N0, M0, G1-2, X); IB (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated.  G3: Poorly differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


name: Acute Myocardial Injury without Ischemia, Heart Failure, Ventricular Dysfunction, or Myocarditis Related to COVID-19

description: Acute myocardial injury, without evidence of acute ischemia, heart failure, a newly reduced left or right ventricular ejection fraction, cardiogenic shock, or myocarditis in a patient with probable or confirmed acute COVID-19.


name: Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8

description: Stage IIIB includes: (T2, N2, M0, Any G); (T3, N1-2, M0, Any G); (T4a, N0-1, M0, Any G). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Advanced gastric carcinoma

description: Gastric carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment.


Refractory Dedifferentiated Liposarcoma

description: Dedifferentiated liposarcoma that does not respond to treatment.


name: Unresectable Prostate Small Cell Neuroendocrine Carcinoma

description: Prostate small cell neuroendocrine carcinoma that is not amenable to surgical resection.


Cellulitis of pharynx

description: Cellulitis of the pharynx.


name: High grade cervical glandular intraepithelial neoplasia

description: Cervical glandular intraepithelial neoplasia characterized by the presence of severe dysplastic changes.


Mucocutaneous candidiasis

description: A fungal infection of the skin, nails, oral and vaginal mucosal sites caused by species of the genus Candida. It manifests with white discoloration of the tongue and swelling, redness, and tenderness of the nails.


Aplastic bone marrow

description: Depletion of stem cells in the bone marrow that results in the lack of production of hematopoietic cells.


Cerebellar Paraganglioma

description: An extra-adrenal paraganglioma arising from the cerebellum.


name: High Grade Prostatic Intraepithelial Neoplasia

description: Prostatic intraepithelial neoplasia characterized by the presence of morphologically malignant cells lining the acini and ducts.  The malignant cells are enlarged, contain prominent nucleoli, and have increased nuclear/cytoplasmic ratio.  The malignant cells may grow within the ducts and acini in four architectural patterns: flat, tufting, micropapillary, and cribriform.  The presence of high grade prostatic intraepithelial neoplasia in needle biopsy is a risk factor for the subsequent detection of carcinoma on repeat biopsy.


Stage IV Ureter Cancer AJCC v7

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat.  N0: No regional lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  N1: Distant metastasis.  (AJCC 7th ed.)


name: Mixed Phenotype Acute Leukemia, B/T/Myeloid

description: A very rare mixed phenotype acute leukemia in which the blasts show evidence of B-cell, T-cell, and myeloid lineage but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation.


name: Bladder Urothelial Carcinoma, High Grade

description: Bladder urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


name: Post transplant Epstein-Barr virus associated lymphoproliferative disorder

description: A lymphoproliferative disorder that develops following organ transplantation and is associated with Epstein-Barr virus infection.


name: Stage I Lentigo Maligna Melanoma AJCC v7

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


name: Lacrimal Drainage System Mucoepidermoid Carcinoma

description: A carcinoma that arises from the lacrimal sac. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type.


Paratesticular tumor

description: A benign, borderline, or malignant neoplasm that affects the paratesticular structures.


name: Pathologic Stage III Merkel Cell Carcinoma AJCC v8

description: Stage III includes: IIIA: (T1-4, N1a(sn) or N1a, M0); (T0, N1b, M0); IIIB: (T1-4, N1b-3, M0). T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1a(sn): Clinically occult regional lymph node metastasis identified only by sentinel lymph node biopsy. N1a: Clinically occult regional lymph node metastasis following lymph node dissection. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. N2: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis. N3: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) with lymph node metastasis. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)