dehydroepiandrosterone

An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.


N-palmitoylethanolamine

An N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid.


bacterial meningitis

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Inflammation of the membranes surrounding the brain and spinal cord due to a bacterial infection.


SHOT1_HUMAN Shootin-1 (sprot)

A shootin-1 that is encoded in the genome of human.


IL16_HUMAN Pro-interleukin-16 (sprot)

An interleukin-16 that is encoded in the genome of human.


L-serine

The L-enantiomer of serine.


name: SRPK1_HUMAN SRSF protein kinase 1 (sprot)

description: An SRSF protein kinase 1 that is encoded in the genome of human.


name: PXMP2_HUMAN Peroxisomal membrane protein 2 (sprot)

description: A peroxisomal membrane protein 2 that is encoded in the genome of human.


name: PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (sprot)

description: A peroxisome proliferator-activated receptor gamma that is encoded in the genome of human.


name: PSMD4_HUMAN 26S proteasome non-ATPase regulatory subunit 4 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 4 that is encoded in the genome of human.


venetoclax

A member of the class of pyrrolopyridines that is a potent inhibitor of the antiapoptotic protein B-cell lymphoma 2. It is used for treamtment of chronic lymphocytic leukemia with 17p deletion.


blindness (disorder)

description: The lack of vision. It is caused by neurological or physiological factors.


MKS3_HUMAN Meckelin (sprot)

A meckelin that is encoded in the genome of human.


WNT5A_HUMAN Protein Wnt-5a (sprot)

A protein Wnt-5a that is encoded in the genome of human.


name: CCL2_HUMAN C-C motif chemokine 2 (sprot)

description: A C-C motif chemokine 2 that is encoded in the genome of human.


name: IF4G2_HUMAN Eukaryotic translation initiation factor 4 gamma 2 (sprot)

description: A eukaryotic translation initiation factor 4 gamma 2 that is encoded in the genome of human.


name: MK06_HUMAN Mitogen-activated protein kinase 6 (sprot)

description: A mitogen-activated protein kinase 6 that is encoded in the genome of human.


name: TDRD7_HUMAN Tudor domain-containing protein 7 (sprot)

description: A tudor domain-containing protein 7 that is encoded in the genome of human.


name: CNMD_HUMAN Leukocyte cell-derived chemotaxin 1 (sprot)

description: A chondromodulin-1 that is encoded in the genome of human.


oleandrin

A steroid saponin that consists of oleandrigenin having a 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl residue attached to the oxygen function at position 3.


name: CD80_HUMAN T-lymphocyte activation antigen CD80 (sprot)

description: A CD80 molecule that is encoded in the genome of human.


oligomycin

Any of the 26-membered ring macrolides produced by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases.


floxuridine

A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.


tunicamycin

A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine.  The homologues vary in the composition of the fatty acid moiety.


pitavastatin

A dihydroxy monocarboxylic acid that is (6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]hept-6-enoic acid in which the two hydroxy groups are located at positions 3 and 5 (the 3R,5S-stereoisomer). Used as its calcium salt for treatment of hypercholesterolemia (elevated levels of cholesterol in the blood) on patients unable to sufficiently lower their cholesterol levels by diet and exercise.


NANO3_HUMAN Nanos homolog 3 (sprot)

A nanos homolog 3 that is encoded in the genome of human.


name: RAB10_HUMAN Ras-related protein Rab-10 (sprot)

description: A Ras-related protein Rab-10 that is encoded in the genome of human.


name: ATG7_HUMAN Ubiquitin-like modifier-activating enzyme ATG7 (sprot)

description: A ubiquitin-like modifier-activating enzyme ATG7 that is encoded in the genome of human.


name: SRBP2_HUMAN Sterol regulatory element-binding protein 2 (sprot)

description: A sterol regulatory element-binding protein 2 that is encoded in the genome of human.


REVERSINE

A member of the class of purines that is 9H-purine in which the hydrogens at positions 2 and 6 are replaced by a [4-(morpholin-4-yl)phenyl]nitrilo group and a cyclohexylamino group, respectively.


rous sarcoma

description: A fibrosarcoma, originally observed in a Plymouth Rock hen, now thought to be an expression of infection by certain viruses of the avian leukosis-sarcoma complex in the family


valsartan

A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a  [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits  antihypertensive activity.


PODO_HUMAN Podocin (sprot)

A podocin that is encoded in the genome of human.


potassium chloride

A metal chloride salt with a K(+) counterion.


Cryptococcal meningitis

description: Meningeal inflammation produced by cryptococcus neoformans, an encapsulated yeast that tends to infect individuals with acquired immunodeficiency syndrome and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature headache; nausea; photophobia; focal neurologic deficits; seizures; cranial neuropathies; and hydrocephalus. (From Adams et al., Principles of Neurology, 6th ed, pp721-2)


L-citrulline

The L-enantiomer of citrulline.


triiodothyronine

An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.


L-leucine

The L-enantiomer of leucine.


H4_HUMAN Histone H4 (sprot)

A histone H4 that is encoded in the genome of human.


caffeic acid

A hydroxycinnamic acid that is cinnamic acid in which the phenyl ring is substituted by hydroxy groups at positions 3 and 4. It exists in cis and trans forms; the latter is the more common.


brain edema

description: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see hypoxia, brain). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of csf flow (e.g., obstructive hydrocephalus). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)


caspofungin

A semisynthetic cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall.


agranulocytosis

description: A decrease in the number of mature granulocytes (neutrophils, eosinophils, and basophils) in the peripheral blood.


PENTACHLOROPHENOL

A  chlorophenol that is phenol substituted by 5 chloro groups.


name: GDF15_HUMAN Growth/differentiation factor 15 (sprot)

description: A growth/differentiation factor 15 that is encoded in the genome of human.


ITA5_HUMAN Integrin alpha-5 (sprot)

An integrin alpha-5 that is encoded in the genome of human.


atypical teratoid rhabdoid tumor

description: Atypical teratoid rhabdoid tumor (ATRT) is a highly malignant central nervous system (CNS) rhabdoid tumor (RT) found almost exclusively in children.


CCN4_HUMAN CCN family member 4 (sprot)

A CCN family member 4 that is encoded in the genome of human.


name: KCJ11_HUMAN ATP-sensitive inward rectifier potassium channel 11 (sprot)

description: An ATP-sensitive inward rectifier potassium channel 11 that is encoded in the genome of human.


CARNITINE

An amino-acid betaine that is butanoate substituted with a hydroxy group at position C-3 and a trimethylammonium group at C-4.


AIDS

description: A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin lymphoma and Kaposi sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood.


AMPH_HUMAN Amphiphysin (sprot)

An amphiphysin that is encoded in the genome of human.


amiloride

A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.


Cachexia

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Severe weight loss, wasting of muscle, loss of appetite, and general debility related to a chronic disease.


name: chronic myelogenous leukemia, BCR-ABL1 positive

description: A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival.


name: HSP7C_HUMAN Heat shock cognate 71 kDa protein (sprot)

description: A heat shock cognate 71 kDa protein that is encoded in the genome of human.


name: ARF1_HUMAN ADP-ribosylation factor 1 (sprot)

description: An ADP-ribosylation factor 1 that is encoded in the genome of human.


VIME_HUMAN Vimentin (sprot)

A vimentin that is encoded in the genome of human.


name: FERM2_HUMAN Fermitin family homolog 2 (sprot)

description: A fermitin family homolog 2 that is encoded in the genome of human.


name: FBLI1_HUMAN Filamin-binding LIM protein 1 (sprot)

description: A filamin-binding LIM protein 1 that is encoded in the genome of human.


name: GAL3A_HUMAN Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial (sprot)

description: A glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial that is encoded in the genome of human.


name: RAP2C_HUMAN Ras-related protein Rap-2c (sprot)

description: A Ras-related protein Rap-2c that is encoded in the genome of human.


fluvoxamine

An oxime O-ether that is benzene substituted by a (1E)-N-(2-aminoethoxy)-5-methoxypentanimidoyl group at position 1 and a trifluoromethyl group at position 4. It is a selective serotonin reuptake inhibitor that is used for the treatment of obsessive-compulsive disorder.


name: CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)

description: A voltage-dependent L-type calcium channel subunit alpha-1C that is encoded in the genome of human.


name: B2CL1_HUMAN Bcl-2-like protein 1 (sprot)

description: A Bcl-2-like protein 1 that is encoded in the genome of human.


name: SRGP3_HUMAN SLIT-ROBO Rho GTPase-activating protein 3 (sprot)

description: A SLIT-ROBO Rho GTPase-activating protein 3 that is encoded in the genome of human.


Necrolytic migratory erythema

description: Acral or periorificial lesions that evolve in recurrent crops, with an annular and migratory distribution.


name: ALDH2_HUMAN Aldehyde dehydrogenase, mitochondrial (sprot)

description: An aldehyde dehydrogenase, mitochondrial that is encoded in the genome of human.


PRSS8_HUMAN Prostasin (sprot)

A prostasin that is encoded in the genome of human.


name: UCP3_HUMAN Putative mitochondrial transporter UCP3 (sprot)

description: A putative mitochondrial transporter UCP3 that is encoded in the genome of human.


monomethyl fumarate

A dicarboxylic acid monoester resulting from the formal condensation of one of the carboxy groups of fumaric acid with methanol. Is is a metabolite of dimethyl fumarate and used for the the treatment of patients with relapsing multiple sclerosis (MS). It also induces the NFE2L2 (Nrf2) transcription factor by  binding to KEAP1.


name: CD20_HUMAN B-lymphocyte antigen CD20 (sprot)

description: A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of human.


temozolomide

An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant  glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.


name: SOCS5_HUMAN Suppressor of cytokine signaling 5 (sprot)

description: A suppressor of cytokine signaling 5 that is encoded in the genome of human.


name: F263_HUMAN 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (sprot)

description: A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 that is encoded in the genome of human.


name: SOX4_HUMAN Transcription factor SOX-4 (sprot)

description: A transcription factor SOX-4 that is encoded in the genome of human.


acute respiratory failure

description: Life-threatening respiratory failure that develops rapidly. Causes include injury, sepsis, drug overdose, and pancreatitis. It manifests with dyspnea and cyanosis and may lead to cardiovascular shock.


name: R9BP_HUMAN Regulator of G-protein signaling 9-binding protein (sprot)

description: A regulator of G-protein signaling 9-binding protein that is encoded in the genome of human.


name: RGS11_HUMAN Regulator of G-protein signaling 11 (sprot)

description: A regulator of G-protein signaling 11 that is encoded in the genome of human.


erythromycin

An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.


name: A1AG1_HUMAN Alpha-1-acid glycoprotein 1 (sprot)

description: An alpha-1-acid glycoprotein 1 that is encoded in the genome of human.


CP3A4_HUMAN Cytochrome P450 3A4 (sprot)

A cytochrome P450 3A4 that is encoded in the genome of human.


HEP2_HUMAN Heparin cofactor 2 (sprot)

A heparin cofactor 2 that is encoded in the genome of human.


name: FHR1_HUMAN Complement factor H-related protein 1 (sprot)

description: A complement factor H-related protein 1 that is encoded in the genome of human.


name: PPR3C_HUMAN Protein phosphatase 1 regulatory subunit 3C (sprot)

description: A protein phosphatase 1 regulatory subunit 3C that is encoded in the genome of human.


name: BUD31_HUMAN Protein BUD31 homolog (sprot)

description: A protein BUD31 that is encoded in the genome of human.


endemic goiter

description: Thyroid gland enlargement caused by inadequate dietary iodine intake. It occurs in areas in which the soil lacks iodine compounds or there is low seafood consumption.


sitosterol

A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.


name: GTR3_HUMAN Solute carrier family 2, facilitated glucose transporter member 3 (sprot)

description: A solute carrier family 2, facilitated glucose transporter member 3 that is encoded in the genome of human.


propofol

A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.


name: A2GL_HUMAN Leucine-rich alpha-2-glycoprotein (sprot)

description: A leucine-rich alpha-2-glycoprotein that is encoded in the genome of human.


name: ERN2_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE2 (sprot)

description: A serine/threonine-protein kinase/endoribonuclease IRE2 that is encoded in the genome of human.


name: HCN2_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (sprot)

description: A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of human.


voriconazole

A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4.


name: ITF2_HUMAN Transcription factor 4 (sprot)

description: A transcription factor 4 that is encoded in the genome of human.


emetine

A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.


B-cell chronic lymphocytic leukemia

description: B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma, and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia. The clinical course is extremely heterogeneous with survival ranging from a few months to several decades.


name: CY24B_HUMAN Cytochrome b-245 heavy chain (sprot)

description: A cytochrome b-245 heavy chain that is encoded in the genome of human.


BORNEOL

A bornane monoterpenoid that is 1,7,7-trimethylbicyclo[2.2.1]heptane substituted by a hydroxy group at position 2.


name: PTGES_HUMAN Prostaglandin E synthase (sprot)

description: A prostaglandin E synthase that is encoded in the genome of human.


Prolonged neonatal jaundice

description: Neonatal jaundice refers to a yellowing of the skin and other tissues of a newborn infant as a result of increased concentrations of bilirubin in the blood. Neonatal jaundice affects over half of all newborns to some extent in the first week of life. Prolonged neonatal jaundice is said to be present if the jaundice persists for longer than 14 days in term infants and 21 days in preterm infants.


A  methyladenine that is adenine substituted with a methyl group at position N-3.


acute myeloid leukemia

description: Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections.


barium sulfate

A metal sulfate with formula BaO4S. Virtually insoluble in water at room temperature, it is mostly used as a component in oil well drilling fluid it occurs naturally as the mineral barite.


name: autoinflammation with arthritis and dyskeratosis


tipifarnib

A quinolone that is 1-methylquinolin-2-one which carries a 3-chlorophenyl and an amino(4-chlorophenyl)(1-methyl-imidazol-5-yl)methyl groups at the 4 and 6 positions, respectively (the R-isomer).


name: IBP7_HUMAN Insulin-like growth factor-binding protein 7 (sprot)

description: An insulin-like growth factor-binding protein 7 that is encoded in the genome of human.


nicotinic acid

A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.


myositis disease

description: An inflammatory disease involving a pathogenic inflammatory response in the muscle tissue.


name: MCM3_HUMAN DNA replication licensing factor MCM3 (sprot)

description: A DNA replication licensing factor MCM3 that is encoded in the genome of human.


JAG1_HUMAN Protein jagged-1 (sprot)

A protein jagged-1 that is encoded in the genome of human.


diffuse large B-cell lymphoma

description: Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common.


cefoperazone

A semi-synthetic parenteral cephalosporin with a tetrazolyl moiety that confers beta-lactamase resistance.


meningitis

description: A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord.


modafinil

A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.


ERBIN_HUMAN Erbin (sprot)

An erbin that is encoded in the genome of human.


phenol

An organic hydroxy compound that consists of benzene bearing a single hydroxy substituent. The parent of the class of phenols.


name: CD1A_HUMAN T-cell surface glycoprotein CD1a (sprot)

description: A T-cell surface glycoprotein CD1a that is encoded in the genome of human.


ammonia

An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms.


name: FABP5_HUMAN Fatty acid-binding protein 5 (sprot)

description: A fatty acid-binding protein 5 that is encoded in the genome of human.


propanoic acid

A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.


name: MSH3_HUMAN DNA mismatch repair protein Msh3 (sprot)

description: A DNA mismatch repair protein Msh3 that is encoded in the genome of human.


name: MOT1_HUMAN Monocarboxylate transporter 1 (sprot)

description: A monocarboxylate transporter 1 that is encoded in the genome of human.


name: UB2L3_HUMAN Ubiquitin-conjugating enzyme E2 L3 (sprot)

description: A ubiquitin-conjugating enzyme E2 L3 that is encoded in the genome of human.


clodronic acid

An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.


name: VSIG4_HUMAN V-set and immunoglobulin domain-containing protein 4 (sprot)

description: A V-set and immunoglobulin domain-containing protein 4 that is encoded in the genome of human.


name: DNJA3_HUMAN DnaJ homolog subfamily A member 3, mitochondrial (sprot)

description: A DnaJ homolog subfamily A member 3, mitochondrial that is encoded in the genome of human.


GELS_HUMAN Gelsolin (sprot)

A gelsolin that is encoded in the genome of human.


thrombocytopenic purpura

description: Purpura associated with a reduction in circulating blood platelets which can result from a variety of factors.


vemurafenib

A pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine which is substituted at position 5 by a p-chlorophenyl group and at positions 3 by a 3-amino-2,6-difluorobenzoyl group, the amino group of which has undergone formal condensation with propane-1-sulfonic acid to give the corresponding sulfonamide. An inhibitor of BRAF and other kinases.


name: LONM_HUMAN Lon protease homolog, mitochondrial (sprot)

description: A Lon protease, mitochondrial that is encoded in the genome of human.


IL24_HUMAN Interleukin-24 (sprot)

An interleukin-24 that is encoded in the genome of human.


chlorogenic acid

A cinnamate ester obtained by formal condensation of the carboxy group of trans-caffeic acid with the 3-hydroxy group of quinic acid. It is an intermediate metabolite in the biosynthesis of lignin.


name: NKX22_HUMAN Homeobox protein Nkx-2.2 (sprot)

description: A homeobox protein Nkx-2.2 that is encoded in the genome of human.


PKD2_HUMAN Polycystin-2 (sprot)

A polycystin-2 that is encoded in the genome of human.


gingivitis

description: A disorder involving inflammation of the gums; may affect surrounding and supporting structures of the teeth.


name: HAP1_HUMAN Huntingtin-associated protein 1 (sprot)

description: A huntingtin-associated protein 1 that is encoded in the genome of human.


name: TFDP2_HUMAN Transcription factor Dp-2 (sprot)

description: A transcription factor Dp-2 that is encoded in the genome of human.


name: DIESL_HUMAN DGAT1/2-independent enzyme synthesizing storage lipids (sprot)

description: A DGAT1/2-independent enzyme synthesizing storage lipids that is encoded in the genome of human.


Skeletal muscle hypertrophy

description: Abnormal increase in muscle size and mass not due to training.


PDPN_HUMAN Podoplanin (sprot)

A podoplanin that is encoded in the genome of human.


TTHY_HUMAN Transthyretin (sprot)

A transthyretin that is encoded in the genome of human.


penicillamine

An optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning.


name: CXCR2_HUMAN C-X-C chemokine receptor type 2 (sprot)

description: A C-X-C chemokine receptor type 2 that is encoded in the genome of human.


indomethacin

A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.


cladribine

2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in  lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including  hairy-cell leukaemia and chronic lymphocytic leukaemia.


name: DDB2_HUMAN DNA damage-binding protein 2 (sprot)

description: A DNA damage-binding protein 2 that is encoded in the genome of human.


moclobemide

A member of the class of  benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.


nonsyndromic congenital nail disorder 1

description: Nail dysplasia is an idiopathic nail dystrophy, beginning in early childhood, and characterized by excessive longitudinal striations and loss of nail luster affecting all 20 nails.


busulfan

A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.


follicular lymphoma

description: Follicular lymphoma is a form of non-Hodgkin lymphoma characterized by a proliferation of B cells whose nodular structure of follicular architecture is preserved.


phenylephrine

A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.


name: APR_HUMAN Phorbol-12-myristate-13-acetate-induced protein 1 (sprot)

description: A phorbol-12-myristate-13-acetate-induced protein 1 that is encoded in the genome of human.


Atypical behavior

description: Atypical behavior is an abnormality in a person's actions, which can be controlled or modulated by the will of the individual. While abnormal behaviors can be difficult to control, they are distinct from other abnormal actions that cannot be affected by the individual's will.


CD44_HUMAN CD44 antigen (sprot)

A CD44 molecule that is encoded in the genome of human.


name: GLI1_HUMAN Zinc finger protein GLI1 (sprot)

description: A zinc finger protein GLI1 that is encoded in the genome of human.


pulmonary arterial hypertension

description: Pulmonary arterial hypertension (PAH) is a group of diseases characterized by mean pulmonary artery pressure >20 mmHg and elevated pulmonary arterial resistance leading to right heart failure. PAH is progressive and potentially fatal. PAH may be idiopathic and/ or familial, have overt features of venous/capillary involvement (pulmonary veno-occlusive disease, PVOD/pulmonary capillary hemangiomatosis, PCH), induced by drug or toxin (drug-or toxin-induced PAH), or associated with other diseases like congenital heart disease, connective tissue disease, HIV, schistosomiasis, portal hypertension (PAH associated with other disease).


liraglutide

A lipopeptide that is an analogue of human GLP-1 in which the lysine residue at position 27 is replaced by arginine and a hexadecanoyl group attached to the remaining lysine via a glutamic acid spacer. Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.


maturity-onset diabetes of the young

description: MODY (maturity-onset diabetes of the young) is a rare, familial, clinically and genetically heterogeneous form of diabetes characterized by young age of onset (generally 10-45 years of age) with maintenance of endogenous insulin production, lack of pancreatic beta-cell autoimmunity, absence of obesity and insulin resistance and extra-pancreatic manifestations in some subtypes.


SPB5_HUMAN Serpin B5 (sprot)

A serpin B5 that is encoded in the genome of human.


acetyl CoA

An acyl-CoA having acetyl as its S-acetyl component.


dementia

description: Loss of intellectual abilities interfering with an individual's social and occupational functions. Causes include Alzheimer's disease, brain injuries, brain tumors, and vascular disorders.


prostate cancer

description: A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas.


gemcitabine

A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.


name: MOT4_HUMAN Monocarboxylate transporter 4 (sprot)

description: A monocarboxylate transporter 4 that is encoded in the genome of human.


name: ULK1_HUMAN Serine/threonine-protein kinase ULK1 (sprot)

description: A serine/threonine-protein kinase ULK1 that is encoded in the genome of human.


name: RORA_HUMAN Nuclear receptor ROR-alpha (sprot)

description: A nuclear receptor ROR-alpha that is encoded in the genome of human.


name: ARI1_HUMAN E3 ubiquitin-protein ligase ARIH1 (sprot)

description: An E3 ubiquitin-protein ligase ARIH1 that is encoded in the genome of human.


name: RNH2C_HUMAN Ribonuclease H2 subunit C (sprot)

description: A ribonuclease H2 subunit C that is encoded in the genome of human.


batimastat

A secondary carboxamide resulting from the formal condensation of the carboxy group of (2S,3R)-5-methyl-3-{[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-2-[(thiophen-2-ylsulfanyl)methyl]hexanoic acid with the amino group of hydroxylamine. It a broad-spectrum matrix metalloprotease inhibitor.


pulmonary fibrosis

description: Chronic progressive interstitial lung disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure, or right heart failure. Causes include chronic inflammatory processes, exposure to environmental irritants, radiation therapy, autoimmune disorders, certain drugs, or it may be idiopathic (no identifiable cause).


tenofovir disoproxil

An organic phosphonate that is the disoproxil ester of tenofovir. A prodrug for tenofovir, an HIV-1 reverse transcriptase inhibitor, tenofovir disoproxil is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.


Low-molecular-weight proteinuria

description: Excretion in urine of proteins of a size smaller than albumin (molecular weight 69 kD).


Ebola hemorrhagic fever

description: A viral hemorrhagic fever that is caused by the Ebola virus, which is transmitted by contact with infected animals or humans; it is characterized by high fever, unexplained bleeding, and a high mortality rate.


name: STXB1_HUMAN Syntaxin-binding protein 1 (sprot)

description: A syntaxin-binding protein 1 that is encoded in the genome of human.


name: CCL26_HUMAN C-C motif chemokine 26 (sprot)

description: A C-C motif chemokine 26 that is encoded in the genome of human.


name: ACSL1_HUMAN Long-chain-fatty-acid--CoA ligase 1 (sprot)

description: A long-chain-fatty-acid--CoA ligase 1 that is encoded in the genome of human.


name: ADPRS_HUMAN ADP-ribosylhydrolase ARH3 (sprot)

description: An ADP-ribosylhydrolase ARH3 that is encoded in the genome of human.


carbidopa

3-(3,4-Dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used (commonly as its hydrate) in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.


pontocerebellar hypoplasia type 2

description: Pontocerebellar hypoplasia type 2 (PCH2) is the most common subtype of pontocerebellar hypoplasia characterized by neonatal onset and a lack of voluntary motor development and later progressive microencephaly, generalized clonus, development of chorea and spasticity. The majority of patients will not reach puberty.


name: NKG2D_HUMAN NKG2-D type II integral membrane protein (sprot)

description: An NKG2-D type II integral membrane protein that is encoded in the genome of human.


name: PHLP_HUMAN Phosducin-like protein (sprot)

description: A phosducin-like protein that is encoded in the genome of human.


dorsomorphin

A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.


PRS55_HUMAN Serine protease 55 (sprot)

A serine protease 55 that is encoded in the genome of human.


sulfate

A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid.


phosphatidylcholine (16:1/20:5)

A phosphatidylcholine 36:6 in which the fatty acyl groups at positions 1 and 2 are specified as C16:1 and C20:5 respectively.


name: PON1_HUMAN Serum paraoxonase/arylesterase 1 (sprot)

description: A serum paraoxonase/arylesterase 1 that is encoded in the genome of human.


name: TERF2_HUMAN Telomeric repeat-binding factor 2 (sprot)

description: A telomeric repeat-binding factor 2 that is encoded in the genome of human.


triglyceride

Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.


L-lysine

An L-alpha-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of L-lysine; major species at pH 7.3.


inherited Creutzfeldt-Jakob disease

description: Inherited or familial Creutzfeldt-Jakob disease (fCJD) is a very rare form of genetic prion disease characterized by typical CJD features (rapidly progressive dementia, personality/behavioral changes, psychiatric disorders, myoclonus, and ataxia) with a genetic cause and sometimes a family history of dementia.


ulcer disease

description: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.


name: PLS1_HUMAN Phospholipid scramblase 1 (sprot)

description: A phospholipid scramblase 1 that is encoded in the genome of human.


benznidazole

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.


LYAM1_HUMAN L-selectin (sprot)

An L-selectin that is encoded in the genome of human.


dactolisib

An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.


cisatracurium

A diester that is the (1R,1'R,2R,2'R)-diastereoisomer of atracurium, a quaternary ammonium ion  consisting of pentane-1,5-diol with both hydroxy functions bearing 3-[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolinium-2(1H)-yl]propanoyl groups.  The active species in the skeletal muscle relaxant cisatracurium besylate.


name: CCR2_HUMAN C-C chemokine receptor type 2 (sprot)

description: A C-C chemokine receptor type 2 that is encoded in the genome of human.


octopamine

A member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates.


Parkinson disease

description: A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.


name: RS27_HUMAN Small ribosomal subunit protein eS27 (sprot)

description: A small ribosomal subunit protein eS27 that is encoded in the genome of human.


tienilic acid

An aromatic ketone that is 2,3-dichlorophenoxyacetic acid in which the hydrogen at position 4 on the benzene ring is replaced by a thiophenecarbonyl group. A loop diuretic used to treat hypertension, it was withdrawn from the market in 1982 due to links with hepatitis.


A 3-hydroxy-5alpha-pregnan-20-one in which the hydroxy group at position 3 has alpha-configuration. It is a metabolite of the sex hormone progesterone and used for the treatment of postpartum depression in women.


name: S6A13_HUMAN Sodium- and chloride-dependent GABA transporter 2 (sprot)

description: A sodium- and chloride-dependent GABA transporter 2 that is encoded in the genome of human.


gabapentin

A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.


central retinal artery occlusion

description: Blockage of the central retinal artery.


name: DMP1_HUMAN Dentin matrix acidic phosphoprotein 1 (sprot)

description: A dentin matrix acidic phosphoprotein 1 that is encoded in the genome of human.


name: CSF3_HUMAN Granulocyte colony-stimulating factor (sprot)

description: A granulocyte colony-stimulating factor that is encoded in the genome of human.


PALLD_HUMAN Palladin (sprot)

A palladin that is encoded in the genome of human.


name: DDIT4_HUMAN DNA damage-inducible transcript 4 protein (sprot)

description: A DNA damage-inducible transcript 4 protein that is encoded in the genome of human.


name: NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 (sprot)

description: A NACHT, LRR and PYD domains-containing protein 3 that is encoded in the genome of human.


name: CCR6_HUMAN C-C chemokine receptor type 6 (sprot)

description: A C-C chemokine receptor type 6 that is encoded in the genome of human.


sodium thiosalicylate

A sulfanylbenzoic acid that is the 2-sulfanyl derivative of benzoic acid.


MT1X_HUMAN Metallothionein-1X (sprot)

A metallothionein-1X that is encoded in the genome of human.


Dysesthesia

description: Painful sensations elicited by a nonpainful cutaneous stimulus such as a light touch or gentle stroking over affected areas of the body. Sometimes referred to as hyperpathia or hyperalgesia. Often perceived as an intense burning, dyesthesias may outlast the stimulus by several seconds.


diacylglycerol (18:1/22:4/0:0)

A 1,2-diglyceride in which the fatty acyl groups at positions 1 and 2 are specified as C18:1 and C22:4 respectively.


diacylglycerol (18:1/20:4/0:0)

A 1,2-diglyceride in which the fatty acyl groups at positions 1 and 2 are specified as C18:1 and C20:4 respectively.


name: STIM1_HUMAN Stromal interaction molecule 1 (sprot)

description: A stromal interaction molecule 1 that is encoded in the genome of human.


geldanamycin

An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.


hidradenitis suppurativa

description: A chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident.


thyroid gland carcinoma

description: A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic.


diflunisal

An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position.


CARBON MONOXIDE

A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.


P2RX2_HUMAN P2X purinoceptor 2 (sprot)

A P2X purinoceptor 2 that is encoded in the genome of human.


thymol

A phenol that is a natural monoterpene derivative of cymene.


name: TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 (sprot)

description: A transient receptor potential cation channel TRPV3 that is encoded in the genome of human.


name: HNRPD_HUMAN Heterogeneous nuclear ribonucleoprotein D0 (sprot)

description: A heterogeneous nuclear ribonucleoprotein D0 that is encoded in the genome of human.


aneuploidy

description: Chromosomal disorder consisting of the presence a chromosomal abnormality in which there is an addition or loss of chromosomes within a set.


NOX1_HUMAN NADPH oxidase 1 (sprot)

An NADPH oxidase 1 that is encoded in the genome of human.


name: Progressive loss of facial adipose tissue


A divalent metal cation in which the metal is manganese.


DEOXYURIDINE

A pyrimidine 2'-deoxyribonucleoside having uracil as the nucleobase.


name: CCL1_HUMAN C-C motif chemokine 1 (sprot)

description: A C-C motif chemokine 1 that is encoded in the genome of human.


chromium atom

A chromium group element atom that has atomic number 24.


DNLI1_HUMAN DNA ligase 1 (sprot)

A DNA ligase 1 that is encoded in the genome of human.


avibactam

A member of the class of azabicycloalkanes that is (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide in which the amino hydrogen at position 6 is replaced by a sulfooxy group. Used (in the form of its sodium salt) in combination with ceftazidime pentahydrate for the treatment of complicated urinary tract infections including pyelonephritis.


diroleuton

An icosatrienoic acid having three cis double bonds at positions 8, 11 and 14.


name: COX1_HUMAN Cytochrome c oxidase subunit 1 (sprot)

description: A cytochrome c oxidase subunit 1 that is encoded in the genome of human.


name: ABCA4_HUMAN Retinal-specific phospholipid-transporting ATPase ABCA4 (sprot)

description: A retinal-specific phospholipid-transporting ATPase ABCA4 that is encoded in the genome of human.


ATLA1_HUMAN Atlastin-1 (sprot)

An atlastin-1 that is encoded in the genome of human.


SMOX_HUMAN Spermine oxidase (sprot)

A spermine oxidase that is encoded in the genome of human.


name: LPAR1_HUMAN Lysophosphatidic acid receptor 1 (sprot)

description: A lysophosphatidic acid receptor 1 that is encoded in the genome of human.


name: FANCJ_HUMAN Fanconi anemia group J protein (sprot)

description: A Fanconi anemia group J protein that is encoded in the genome of human.


name: RABX5_HUMAN Rab5 GDP/GTP exchange factor (sprot)

description: A Rab5 GDP/GTP exchange factor that is encoded in the genome of human.


name: IKKB_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit beta (sprot)

description: An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of human.


periapical periodontitis

description: Inflammation of the periapical tissue. It includes general, unspecified, or acute nonsuppurative inflammation. Chronic nonsuppurative inflammation is periapical granuloma. Suppurative inflammation is periapical abscess.


name: JAK2_HUMAN Tyrosine-protein kinase JAK2 (sprot)

description: A tyrosine-protein kinase JAK2 that is encoded in the genome of human.


name: TRPV1_HUMAN Transient receptor potential cation channel subfamily V member 1 (sprot)

description: A transient receptor potential cation channel TRPV1 that is encoded in the genome of human.


Brain atrophy

description: Partial or complete wasting (loss) of brain tissue that was once present.


NDRG1_HUMAN Protein NDRG1 (sprot)

A protein NDRG1 that is encoded in the genome of human.


ganciclovir

An oxopurine that is  guanine substituted by a [(1,3-dihydroxypropan-2-yl)oxy]methyl group at position 9. Ganciclovir is an antiviral drug used to treat or prevent AIDS-related cytomegalovirus infections.


acute liver failure

description: Rapid deterioration of liver function causing encephalopathy and coagulopathy. It results from damage to the liver parenchyma usually secondary to acetaminophen overdose or viral infections.


SYN1_HUMAN Synapsin-1 (sprot)

A synapsin-1 that is encoded in the genome of human.


AQP4_HUMAN Aquaporin-4 (sprot)

An aquaporin-4 that is encoded in the genome of human.


neuromyelitis optica

description: A rare inflammatory disease of the central nervous system characterized mainly by attacks of uni- or bilateral optic neuritis (ON) and acute myelitis.


NECT3_HUMAN Nectin-3 (sprot)

A nectin-3 that is encoded in the genome of human.


name: WNK1_HUMAN Serine/threonine-protein kinase WNK1 (sprot)

description: A serine/threonine-protein kinase WNK1 that is encoded in the genome of human.


glucosamine

A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2.


urothelial carcinoma

description: A malignant neoplasm derived from the transitional epithelium of the urinary tract (urinary bladder, ureter, urethra, or renal pelvis). It is frequently papillary.


iloperidone

A member of the class of piperidines that is the 4-acetyl-2-methoxyphenyl ether of 3-(piperidin-1-yl)propan-1-ol which is substituted at position 4 of the piperidine ring by a 6-fluoro-1,2-benzoxazol-3-yl group. A member of the group of second generation antipsychotics (also known as an atypical antipsychotics), it is used for the treatment of schizophrenia.


name: GBP1_HUMAN Guanylate-binding protein 1 (sprot)

description: A guanylate-binding protein 1 that is encoded in the genome of human.


ADIPO_HUMAN Adiponectin (sprot)

An adiponectin that is encoded in the genome of human.


ETHYL NITROSOUREA

A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.


central nervous system cancer

description: A malignant neoplasm involving the central nervous system


name: EDNRA_HUMAN Endothelin-1 receptor (sprot)

description: An endothelin-1 receptor that is encoded in the genome of human.


name: MK14_HUMAN Mitogen-activated protein kinase 14 (sprot)

description: A mitogen-activated protein kinase 14 that is encoded in the genome of human.


malathion

A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.


Hepatic necrosis

description: The presence of cell death (necrosis) affecting the liver.


sinonasal undifferentiated carcinoma

description: A rare, highly aggressive carcinoma that arises from the sinonasal tract. It is characterized by the presence of small to medium size malignant cells. The prognosis is poor.


paraplegia

description: Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord.


MYCD_HUMAN Myocardin (sprot)

A myocardin that is encoded in the genome of human.


SALL4_HUMAN Sal-like protein 4 (sprot)

A Sal-like protein 4 that is encoded in the genome of human.


name: PLAG1_HUMAN Zinc finger protein PLAG1 (sprot)

description: A zinc finger protein PLAG1 that is encoded in the genome of human.


name: IMA1_HUMAN Importin subunit alpha-1 (sprot)

description: An importin subunit alpha-1 that is encoded in the genome of human.


ANGI_HUMAN Angiogenin (sprot)

An angiogenin that is encoded in the genome of human.


name: PDK1_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (sprot)

description: A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial that is encoded in the genome of human.


name: S29A4_HUMAN Equilibrative nucleoside transporter 4 (sprot)

description: An equilibrative nucleoside transporter 4 that is encoded in the genome of human.


clemastine

2-[(2R)-1-Methylpyrrolidin-2-yl]ethanol in which the hydrogen of the hydroxy group is substituted by a 1-(4-chlorophenyl)-1-phenylethyl group (R configuration). An antihistamine with antimuscarinic and moderate sedative properties, it is used as its fumarate salt for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin conditions.


TRINITROTOLUENE

A trinitrotoluene having the nitro groups at positions 2, 4 and 6.


name: SPY2_HUMAN Protein sprouty homolog 2 (sprot)

description: A protein sprouty homolog 2 that is encoded in the genome of human.


(+)-TAXIFOLIN

A taxifolin that has (2R,3R)-configuration.


L-tryptophan

The L-enantiomer of tryptophan.


name: FOXM1_HUMAN Forkhead box protein M1 (sprot)

description: A forkhead box protein M1 that is encoded in the genome of human.


name: RPGF3_HUMAN Rap guanine nucleotide exchange factor 3 (sprot)

description: A Rap guanine nucleotide exchange factor 3 that is encoded in the genome of human.


ACRYLIC ACID

A alpha,beta-unsaturated monocarboxylic acid that is ethene substituted by a carboxy group.


name: DPP4_HUMAN Dipeptidyl peptidase 4 (sprot)

description: A dipeptidyl peptidase 4 that is encoded in the genome of human.


name: TNF10_HUMAN Tumor necrosis factor ligand superfamily member 10 (sprot)

description: A tumor necrosis factor ligand superfamily member 10 that is encoded in the genome of human.


diphtheria

description: A Gram-positive bacterial infection caused by Corynebacterium diphtheriae. It usually involves the oral cavity, pharynx, and nasal cavity. Patients develop pseudomembranes in the affected areas and manifest signs and symptoms of an upper respiratory infection. The diphtheria toxin may cause myocarditis, polyneuritis, and other systemic effects.


status asthmaticus

description: An acute exacerbation of asthma, characterized by inadequate response to initial bronchodilators.


STX1A_HUMAN Syntaxin-1A (sprot)

A syntaxin-1A that is encoded in the genome of human.


hypoglycemia

description: Abnormally low level of glucose in the blood.


domperidone

1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.


glomerulosclerosis

description: A hardening of the kidney glomerulus caused by scarring of the blood vessels.


name: TAF6_HUMAN Transcription initiation factor TFIID subunit 6 (sprot)

description: A transcription initiation factor TFIID subunit 6 that is encoded in the genome of human.


name: BMR1A_HUMAN Bone morphogenetic protein receptor type-1A (sprot)

description: A BMP receptor type-1A that is encoded in the genome of human.


name: PGFRA_HUMAN Platelet-derived growth factor receptor alpha (sprot)

description: An alpha-type platelet-derived growth factor receptor that is encoded in the genome of human.


ethambutol

An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.


name: PO2F1_HUMAN POU domain, class 2, transcription factor 1 (sprot)

description: A POU domain, class 2, transcription factor 1 that is encoded in the genome of human.


name: PKHG5_HUMAN Pleckstrin homology domain-containing family G member 5 (sprot)

description: A pleckstrin homology domain-containing family G member 5 that is encoded in the genome of human.


renal fibrosis

description: A final common manifestation of a wide variety of chronic kidney diseases characterized by glomerulosclerosis and tubulointerstitial fibrosis.


skin cancer

description: A malignant neoplasm involving the zone of skin


SYUA_HUMAN Alpha-synuclein (sprot)

An alpha-synuclein that is encoded in the genome of human.


CATD_HUMAN Cathepsin D (sprot)

A cathepsin D that is encoded in the genome of human.


DB113_HUMAN Beta-defensin 113 (sprot)

A beta-defensin 113 that is encoded in the genome of human.


angiotensin II

An angiotensin II that acts on the central nervous system (PDB entry: 1N9V).


name: KCNK2_HUMAN Potassium channel subfamily K member 2 (sprot)

description: A potassium channel subfamily K member 2 that is encoded in the genome of human.


name: NCAM1_HUMAN Neural cell adhesion molecule 1 (sprot)

description: A neural cell adhesion molecule 1 that is encoded in the genome of human.


name: FKBP4_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP4 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP4 that is encoded in the genome of human.


name: TIMP3_HUMAN Metalloproteinase inhibitor 3 (sprot)

description: A metalloproteinase inhibitor 3 that is encoded in the genome of human.


carvacrol

A phenol that is a natural monoterpene derivative of cymene. An inhibitor of  bacterial growth, it is used as a food additive. Potent activator of the human ion channels transient receptor potential V3 (TRPV3) and A1 (TRPA1).


Lyme disease

description: Lyme disease (named after the towns in the USA where the disease was first identified) is a bacterial infection caused by Borrelia burgdorferi.


gamma-valerolactone

A butan-4-olide that is dihydrofuran-2(3H)-one substituted by a methyl group at position 5. It has been found in the urine samples of humans exposed to n-hexane.


name: ACE_HUMAN Angiotensin-converting enzyme (sprot)

description: An angiotensin-converting enzyme that is encoded in the genome of human.


name: NF2L1_HUMAN Endoplasmic reticulum membrane sensor NFE2L1 (sprot)

description: An endoplasmic reticulum membrane sensor NFE2L1 that is encoded in the genome of human.


name: KDM1A_HUMAN Lysine-specific histone demethylase 1A (sprot)

description: A lysine-specific histone demethylase 1A that is encoded in the genome of human.


nephrogenic systemic fibrosis

description: Nephrogenic systemic fibrosis (NSF) is a rare systemic fibrosing condition observed in renally impaired patients and characterized by a hardening and thickening of the skin with fibrotic plaques or papules, pruritus, joint pain and stiffness, muscle weakness, limitation of range of motion, and yellowed eyes. It is generally associated with administration of gadolinium-based magnetic resonance imaging contrast agents (GBCA) in patients with kidney disease.


name: ATF6A_HUMAN Cyclic AMP-dependent transcription factor ATF-6 alpha (sprot)

description: A cyclic AMP-dependent transcription factor ATF-6 alpha that is encoded in the genome of human.


name: IF16_HUMAN Gamma-interferon-inducible protein 16 (sprot)

description: A gamma-interferon-inducible protein 16 that is encoded in the genome of human.


TRIB2_HUMAN Tribbles homolog 2 (sprot)

A tribbles homolog 2 that is encoded in the genome of human.


name: GRP1_HUMAN RAS guanyl-releasing protein 1 (sprot)

description: A RAS guanyl-releasing protein 1 that is encoded in the genome of human.


A cholestanoid that consists of cholesterol bearing an oxo substituent at position 7.


STMN2_HUMAN Stathmin-2 (sprot)

A stathmin-2 that is encoded in the genome of human.


SYN2_HUMAN Synapsin-2 (sprot)

A synapsin-2 that is encoded in the genome of human.


name: NLRP6_HUMAN NACHT, LRR and PYD domains-containing protein 6 (sprot)

description: A NACHT, LRR and PYD domains-containing protein 6 that is encoded in the genome of human.


A non-proteinogenic alpha-amino acid that is homocysteine in which the thiol group carries an oxo, imino and butyl groups.


name: NAR4_HUMAN Ecto-ADP-ribosyltransferase 4 (sprot)

description: An ecto-ADP-ribosyltransferase 4 that is encoded in the genome of human.


name: HDAC1_HUMAN Histone deacetylase 1 (sprot)

description: A histone deacetylase 1 that is encoded in the genome of human.


name: NCOR2_HUMAN Nuclear receptor corepressor 2 (sprot)

description: A nuclear receptor corepressor 2 that is encoded in the genome of human.


name: PAX7_HUMAN Paired box protein Pax-7 (sprot)

description: A paired box protein Pax-7 that is encoded in the genome of human.


Duchenne muscular dystrophy

description: Duchenne muscular dystrophy (DMD) is a neuromuscular disease characterized by rapidly progressive muscle weakness and wasting due to degeneration of skeletal, smooth and cardiac muscle.


name: NFAC4_HUMAN Nuclear factor of activated T-cells, cytoplasmic 4 (sprot)

description: A nuclear factor of activated T-cells, cytoplasmic 4 that is encoded in the genome of human.


name: DCOR_HUMAN Ornithine decarboxylase (sprot)

description: An ornithine decarboxylase that is encoded in the genome of human.


name: DMTF1_HUMAN Cyclin-D-binding Myb-like transcription factor 1 (sprot)

description: A cyclin-D-binding Myb-like transcription factor 1 that is encoded in the genome of human.


hydralazine

The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.


name: FGF2_HUMAN Fibroblast growth factor 2 (sprot)

description: A fibroblast growth factor 2 that is encoded in the genome of human.


D-lactic acid

An optically active form of lactic acid having (R)-configuration.


name: PSG8_HUMAN Pregnancy-specific beta-1-glycoprotein 8 (sprot)

description: A pregnancy-specific beta-1-glycoprotein 8 that is encoded in the genome of human.


name: E2AK4_HUMAN eIF-2-alpha kinase GCN2 (sprot)

description: An eIF-2-alpha kinase GCN2 that is encoded in the genome of human.


SINAPINATE

A sinapic acid in which the double bond has trans-configuration.


name: MINY4_HUMAN Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (sprot)

description: A probable ubiquitin carboxyl-terminal hydrolase MINDY-4 that is encoded in the genome of human.


DYNASORE

A carbohydrazide resulting from the formal condensation of the hydrazone moiety of 3,4-dihydroxybenzaldehyde hydrazone with the carboxy group of 3-hydroxy-2-naphthoic acid. It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity of dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42.


name: FBLN4_HUMAN EGF-containing fibulin-like extracellular matrix protein 2 (sprot)

description: An EGF-containing fibulin-like extracellular matrix protein 2 that is encoded in the genome of human.


name: MET14_HUMAN N6-adenosine-methyltransferase non-catalytic subunit (sprot)

description: An N6-adenosine-methyltransferase non-catalytic subunit that is encoded in the genome of human.


name: YTDC1_HUMAN YTH domain-containing protein 1 (sprot)

description: A YTH domain-containing protein 1 that is encoded in the genome of human.


cervical cancer

description: A primary or metastatic malignant neoplasm involving the cervix.


metronidazole

A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.


chronic diarrheal disease

description: Chronic form of diarrheal disease.


flavone

The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.


name: PARP2_HUMAN Poly [ADP-ribose] polymerase 2 (sprot)

description: A poly [ADP-ribose] polymerase 2 that is encoded in the genome of human.


name: TBL3_HUMAN Transducin beta-like protein 3 (sprot)

description: A transducin beta-like protein 3 that is encoded in the genome of human.


name: XAF1_HUMAN XIAP-associated factor 1 (sprot)

description: An XIAP-associated factor 1 that is encoded in the genome of human.


name: MSH6_HUMAN DNA mismatch repair protein Msh6 (sprot)

description: A DNA mismatch repair protein Msh6 that is encoded in the genome of human.


name: KDM2B_HUMAN Lysine-specific demethylase 2B (sprot)

description: A lysine-specific demethylase 2B that is encoded in the genome of human.


name: MP2K6_HUMAN Dual specificity mitogen-activated protein kinase kinase 6 (sprot)

description: A dual specificity mitogen-activated protein kinase kinase 6 that is encoded in the genome of human.


citicoline

A member of the class of  phosphocholines that is the chloine ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes.


CHRYSOPHANOL

A trihydroxyanthraquinone that is chrysazin with a methyl substituent at C-3. It has been isolated from Aloe vera and exhibits antiviral and anti-inflammatory activity.


name: VTA1_HUMAN Vacuolar protein sorting-associated protein VTA1 homolog (sprot)

description: A vacuolar protein sorting-associated protein VTA1 that is encoded in the genome of human.


name: LSG1_HUMAN Large subunit GTPase 1 homolog (sprot)

description: A large subunit GTPase 1 that is encoded in the genome of human.


name: M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 (sprot)

description: A mitogen-activated protein kinase kinase kinase 10 that is encoded in the genome of human.


phosphatidylserine (16:1/18:0)

A phosphatidyl-L-serine in which one acyl group has 16 carbons and 1 double bond while the other has 18 carbons and is fully saturated.


atherosclerosis

description: Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen.


name: CR3L2_HUMAN Cyclic AMP-responsive element-binding protein 3-like protein 2 (sprot)

description: A cyclic AMP-responsive element-binding protein 3-like protein 2 that is encoded in the genome of human.


name: ZBT7A_HUMAN Zinc finger and BTB domain-containing protein 7A (sprot)

description: A zinc finger and BTB domain-containing protein 7A that is encoded in the genome of human.


BENZOPHENONE

The simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups.


betacarotene

A cyclic carotene obtained by dimerisation of all-trans-retinol. A strongly-coloured red-orange pigment abundant in plants and fruit and the most active and important provitamin A carotenoid.


toluene

The simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent.


BENZYLAMINE

A primary amine compound having benzyl as the N-substituent. It has been isolated from  Moringa oleifera (horseradish tree).


melanoma

description: A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.


coumarin

A chromenone having the keto group located at the 2-position.


CP2A7_HUMAN Cytochrome P450 2A7 (sprot)

A cytochrome P450 2A that is a translation product of the CYP2A7 gene in human.


name: P3C2B_HUMAN Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (sprot)

description: A phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta that is encoded in the genome of human.


OZONE

An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.


name: RGS1_HUMAN Regulator of G-protein signaling 1 (sprot)

description: A regulator of G-protein signaling 1 that is encoded in the genome of human.


name: PACA_HUMAN Pituitary adenylate cyclase-activating polypeptide (sprot)

description: A pituitary adenylate cyclase-activating polypeptide that is encoded in the genome of human.


uterine corpus endometrial carcinoma

description: A endometrial carcinoma (disease) that involves the body of uterus.


procaine

A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.


name: DISC1_HUMAN Disrupted in schizophrenia 1 protein (sprot)

description: A disrupted in schizophrenia 1 protein that is encoded in the genome of human.


name: BACH2_HUMAN Transcription regulator protein BACH2 (sprot)

description: A transcription regulator protein BACH2 that is encoded in the genome of human.


name: NFE2_HUMAN Transcription factor NF-E2 45 kDa subunit (sprot)

description: A transcription factor NF-E2 45 kDa subunit that is encoded in the genome of human.


oxyquinoline

A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.


lung neoplasm

description: A benign or malignant, primary or metastatic neoplasm involving the lungs. Representative examples of benign neoplasms include adenoma, papilloma, chondroma, and endobronchial lipoma. Representative examples of malignant neoplasms include carcinoma, carcinoid tumor, sarcoma, and lymphoma.


name: PAI1_HUMAN Plasminogen activator inhibitor 1 (sprot)

description: A plasminogen activator inhibitor 1 that is encoded in the genome of human.


name: FGL1_HUMAN Fibrinogen-like protein 1 (sprot)

description: A fibrinogen-like protein 1 that is encoded in the genome of human.


name: PEA15_HUMAN Astrocytic phosphoprotein PEA-15 (sprot)

description: An astrocytic phosphoprotein PEA-15 that is encoded in the genome of human.


name: SCNNA_HUMAN Amiloride-sensitive sodium channel subunit alpha (sprot)

description: An amiloride-sensitive sodium channel subunit alpha that is encoded in the genome of human.


name: TRAF6_HUMAN TNF receptor-associated factor 6 (sprot)

description: A TNF receptor-associated factor 6 that is encoded in the genome of human.


retinoblastoma

description: A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma.


primary effusion lymphoma

description: Primary effusion lymphoma (PEL) is a large B-cell lymphoma located in the body cavities, characterized by pleural, peritoneal, and pericardial fluid lymphomatous effusions and that is always associated with human herpes virus-8 (HHV-8).


name: HMGB1_HUMAN High mobility group protein B1 (sprot)

description: A high mobility group protein B1 that is encoded in the genome of human.


name: GHR_HUMAN Growth hormone receptor (sprot)

description: A growth hormone receptor that is encoded in the genome of human.


name: ARI5A_HUMAN AT-rich interactive domain-containing protein 5A (sprot)

description: An AT-rich interactive domain-containing protein 5A that is encoded in the genome of human.


phosphatidylserine (16:0/22:6)

A phosphatidylserine 38:6 in which the acyl group at C-1 contains 16 carbons and no double bonds while that at C-2 contains 22 carbons and 6 double bonds.


ANT3_HUMAN Antithrombin-III (sprot)

An antithrombin-III that is encoded in the genome of human.


name: BUB1B_HUMAN Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (sprot)

description: A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human.


name: KDM5B_HUMAN Lysine-specific demethylase 5B (sprot)

description: A lysine-specific demethylase 5B that is encoded in the genome of human.


HOMIDIUM BROMIDE

The organic bromide salt of ethidium.


teratocarcinoma

description: A germ cell tumor characterized by the presence of an embryonal carcinoma component and a teratoma component.


diacylglycerol (18:1/18:2/0:0)

A 1,2-diglyceride in which the fatty acyl groups at positions 1 and 2 are specified as C18:1 and C18:2 respectively.


name: 5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (sprot)

description: A 5-hydroxytryptamine receptor 2A that is encoded in the genome of human.


P2RX3_HUMAN P2X purinoceptor 3 (sprot)

A P2X purinoceptor 3 that is encoded in the genome of human.


phloretin

A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'.


propylene glycol

The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.


name: KMT5A_HUMAN N-lysine methyltransferase KMT5A (sprot)

description: An N-lysine methyltransferase KMT5A that is encoded in the genome of human.


carbon dioxide

A one-carbon compound with formula CO2 in which the carbon is attached to each oxygen atom by a double bond. A colourless, odourless gas under normal conditions, it is produced during respiration by all animals, fungi and microorganisms that depend directly or indirectly on living or decaying plants for food.


name: TBCD8_HUMAN TBC1 domain family member 8 (sprot)

description: A TBC1 domain family member 8 that is encoded in the genome of human.


edoxaban

A monocarboxylic acid amide that is used (as its tosylate monohydrate) for the treatment of deep vein thrombosis and pulmonary embolism.


Arterial thrombosis

description: The formation of a blood clot inside an artery.


FBLN2_HUMAN Fibulin-2 (sprot)

A fibulin-2 that is encoded in the genome of human.


adenoma

description: A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated but non-invasive. The neoplastic epithelial cells may or may not display cellular atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes severe it is sometimes called carcinoma in situ. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract.


BTG2_HUMAN Protein BTG2 (sprot)

A protein BTG2 that is encoded in the genome of human.


name: IL4RA_HUMAN Interleukin-4 receptor subunit alpha (sprot)

description: An interleukin-4 receptor subunit alpha that is encoded in the genome of human.


name: ZBT18_HUMAN Zinc finger and BTB domain-containing protein 18 (sprot)

description: A zinc finger and BTB domain-containing protein 18 that is encoded in the genome of human.


name: metabolic dysfunction-associated steatotic liver disease

description: Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as nonalcoholic fatty liver disease or NAFLD) is a type of liver disease that is not caused by alcohol. It typically does not cause symptoms in the early stages, but it can cause health problems due to fat accumulation, inflammation, and scarring in the liver.


thyroid gland disorder

description: A disease involving the thyroid gland.


name: SC6A5_HUMAN Sodium- and chloride-dependent glycine transporter 2 (sprot)

description: A sodium- and chloride-dependent glycine transporter 2 that is encoded in the genome of human.


name: SGPP1_HUMAN Sphingosine-1-phosphate phosphatase 1 (sprot)

description: A sphingosine-1-phosphate phosphatase 1 that is encoded in the genome of human.


CASTANOSPERMINE

A tetrahydroxyindolizidine alkaloid that consists of octahydroindolizine having four hydroxy substituents located at positions 1, 6, 7 and 8 (the 1S,6S,7R,8R,8aR-diastereomer).


epilepsy

description: A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.


ribavirin

A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. A synthetic guanosine analogue, it is an inhibitor of HCV polymerase and possesses a broad spectrum of activity against DNA and RNA viruses.


TNPO1_HUMAN Transportin-1 (sprot)

A transportin-1 that is encoded in the genome of human.


name: ABCA1_HUMAN Phospholipid-transporting ATPase ABCA1 (sprot)

description: A phospholipid-transporting ATPase ABCA1 that is encoded in the genome of human.


name: PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (sprot)

description: A cGMP-specific 3',5'-cyclic phosphodiesterase that is encoded in the genome of human.


proteinuria

description: The presence of abnormal amounts of protein in the urine.


zinc sulfate

A metal sulfate compound having zinc(2+) as the counterion.


dyspepsia

description: An uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach pain, bloating, heartburn, nausea, and vomiting. Causes include gastritis, gastric ulcer, gastroesophageal reflux disease, pancreatic disease, and gallbladder disease.


sorbitol

The D-enantiomer of glucitol (also known as D-sorbitol).


name: PMP22_HUMAN Peripheral myelin protein 22 (sprot)

description: A peripheral myelin protein 22 that is encoded in the genome of human.


amikacin

An amino cyclitol glycoside that is kanamycin A acylated at the N-1 position by a 4-amino-2-hydroxybutyryl group.


name: CXCR3_HUMAN C-X-C chemokine receptor type 3 (sprot)

description: A C-X-C chemokine receptor type 3 that is encoded in the genome of human.


L-isoleucine

The L-enantiomer of isoleucine.


name: S52A1_HUMAN Solute carrier family 52, riboflavin transporter, member 1 (sprot)

description: A solute carrier family 52, riboflavin transporter, member 1 that is encoded in the genome of human.


urethritis

description: Inflammation of the urethra.


phytomenadione

A member of the class of phylloquinones that consists of 1,4-naphthoquinone having methyl and phytyl groups at positions 2 and 3 respectively. The parent of the class of phylloquinones.


name: ERCC6_HUMAN DNA excision repair protein ERCC-6 (sprot)

description: A DNA excision repair protein ERCC-6 that is encoded in the genome of human.


name: TOP2A_HUMAN DNA topoisomerase 2-alpha (sprot)

description: A DNA topoisomerase 2-alpha that is encoded in the genome of human.


THIAZOLIDINEDIONE

A thiazolidenedione carrying oxo substituents at positions 2 and 4.


dimethyl fumarate

An enoate ester resulting from the formal condensation of both carboxy groups of fumaric acid with methanol. Used for treatment of adults with relapsing forms of multiple sclerosis.


name: ULBP2_HUMAN UL16-binding protein 2 (sprot)

description: A UL16-binding protein 2 that is encoded in the genome of human.


hepatitis B virus infection

description: A viral infection caused by the hepatitis B virus.


name: COT2_HUMAN COUP transcription factor 2 (sprot)

description: A COUP transcription factor 2 that is encoded in the genome of human.


Tako-tsubo cardiomyopathy

description: Takotsubo cardiomyopathy (TC) is a recently described acute cardiac syndrome that mimics acute myocardial infarction and is characterized by ischemic chest symptoms, an elevated ST segment on electrocardiogram, and elevated levels of cardiac disease markers.


name: ATF5_HUMAN Cyclic AMP-dependent transcription factor ATF-5 (sprot)

description: A cyclic AMP-dependent transcription factor ATF-5 that is encoded in the genome of human.


name: S22A6_HUMAN Solute carrier family 22 member 6 (sprot)

description: A solute carrier family 22 member 6 that is encoded in the genome of human.


name: prolactin-producing pituitary gland adenoma

description: Prolactinoma is a usually benign neoplasm of the pituitary gland that results in hyperprolactinemia. The most common clinical manifestations are amenorrhea and infertility in women; and impotence, decreased libido and infertility in men.


mucoepidermoid carcinoma

description: A carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It can occur in several anatomic sites, including parotid gland, oral cavity, paranasal sinus, skin, breast, lung, larynx, and lacrimal ducts. It is classified as low or high grade.


alvespimycin

A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group.


name: JUN_HUMAN Transcription factor Jun (sprot)

description: A transcription factor Jun that is encoded in the genome of human.


name: IF5AL_HUMAN Eukaryotic translation initiation factor 5A-1-like (sprot)

description: A eukaryotic translation initiation factor 5A-1-like that is encoded in the genome of human.


name: DNLZ_HUMAN DNL-type zinc finger protein (sprot)

description: A DNL-type zinc finger protein that is encoded in the genome of human.


name: HPS3_HUMAN BLOC-2 complex member HPS3 (sprot)

description: A BLOC-2 complex member HPS3 that is encoded in the genome of human.


trichloroethylene

A member of the class of  chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.


decamethrin

A cyclopropanecarboxylate ester obtained by formal condensation between 3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol. It is the active insecticide of the proinsecticide tralomethrin.


name: STAG2_HUMAN Cohesin subunit SA-2 (sprot)

description: A cohesin subunit SA-2 that is encoded in the genome of human.


CAD11_HUMAN Cadherin-11 (sprot)

A cadherin-11 that is encoded in the genome of human.


SEBACIC ACID

An alpha,omega-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane.


name: FGF1_HUMAN Fibroblast growth factor 1 (sprot)

description: A fibroblast growth factor 1 that is encoded in the genome of human.


name: PLA2R_HUMAN Secretory phospholipase A2 receptor (sprot)

description: A secretory phospholipase A2 receptor that is encoded in the genome of human.


IL4_HUMAN Interleukin-4 (sprot)

An interleukin-4 that is encoded in the genome of human.


name: CSK2B_HUMAN Casein kinase II subunit beta (sprot)

description: A casein kinase II subunit beta that is encoded in the genome of human.


colon adenoma

description: An adenoma that arises from the colon. The group of colonic adenomas includes tubular, villous, and tubulovillous adenomas, traditional serrated adenomas, sessile serrated adenomas/polyps, and familial adenomatous polyposis.


oleoyl-CoA

An octadecenoyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of oleic acid.


name: ZDH11_HUMAN Palmitoyltransferase ZDHHC11 (sprot)

description: A palmitoyltransferase ZDHHC11 that is encoded in the genome of human.


bupropion

An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.


CUL3_HUMAN Cullin-3 (sprot)

A cullin-3 that is encoded in the genome of human.


name: NDC80_HUMAN Kinetochore protein NDC80 homolog (sprot)

description: A kinetochore protein NDC80 that is encoded in the genome of human.


name: SPI1_HUMAN Transcription factor PU.1 (sprot)

description: A transcription factor PU.1 that is encoded in the genome of human.


chenodeoxycholic acid

A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.


name: PGH1_HUMAN Prostaglandin G/H synthase 1 (sprot)

description: A prostaglandin G/H synthase 1 that is encoded in the genome of human.


name: ARID2_HUMAN AT-rich interactive domain-containing protein 2 (sprot)

description: An AT-rich interactive domain-containing protein 2 that is encoded in the genome of human.


name: CSN5_HUMAN COP9 signalosome complex subunit 5 (sprot)

description: A COP9 signalosome complex subunit 5 that is encoded in the genome of human.


telbivudine

A pyrimidine 2'-deoxyribonucleoside that is the L-enantiomer of thymine. A synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase.


dorzolamide

5,6-Dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide in which hydrogens at the 4 and 6 positions are substituted by ethylamino and methyl groups, respectively (4S, trans-configuration). A carbonic anhydrase inhibitor, it is used as the hydrochloride in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.


iridocorneal endothelial syndrome

description: Iridocorneal endothelial (ICE) syndrome describes a group of progressive corneal proliferative endotheliopathies comprised of Chandler syndrome, Cogan-Reese syndrome and essential iris atrophy, affecting mainly young adult females and characterized by iris holes and atrophy, papillary distortion, anterior synechiae, corneal edema and often with secondary glaucoma and corneal decompensation as complications


name: BDNF_HUMAN Brain-derived neurotrophic factor (sprot)

description: A brain-derived neurotrophic factor that is encoded in the genome of human.


TSC1_HUMAN Hamartin (sprot)

A hamartin that is encoded in the genome of human.


name: MK08_HUMAN Mitogen-activated protein kinase 8 (sprot)

description: A mitogen-activated protein kinase 8 that is encoded in the genome of human.


MYH9_HUMAN Myosin-9 (sprot)

A myosin-9 that is encoded in the genome of human.


name: PRDM1_HUMAN PR domain zinc finger protein 1 (sprot)

description: A PR domain zinc finger protein 1 that is encoded in the genome of human.


phenformin

A member of the class of biguanides that is  biguanide in which one of the terminal nitrogen atoms is substituted by a 2-phenylethyl group. It was used as an anti-diabetic drug but was later withdrawn from the market due to potential risk of  lactic acidosis.


name: JAK3_HUMAN Tyrosine-protein kinase JAK3 (sprot)

description: A tyrosine-protein kinase JAK3 that is encoded in the genome of human.


name: NRF1_HUMAN Nuclear respiratory factor 1 (sprot)

description: A nuclear respiratory factor 1 that is encoded in the genome of human.


miconazole

A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.


name: S40A1_HUMAN Solute carrier family 40 member 1 (sprot)

description: A solute carrier family 40 member 1 that is encoded in the genome of human.


BACE2_HUMAN Beta-secretase 2 (sprot)

A beta-secretase 2 that is encoded in the genome of human.


ISOQUERCETIN

A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells


name: AAKB1_HUMAN 5'-AMP-activated protein kinase subunit beta-1 (sprot)

description: A 5'-AMP-activated protein kinase subunit beta-1 that is encoded in the genome of human.


name: RIOK2_HUMAN Serine/threonine-protein kinase RIO2 (sprot)

description: A serine/threonine-protein kinase RIO2 that is encoded in the genome of human.


HESPERIDIN

A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.


name: MEGF8_HUMAN Multiple epidermal growth factor-like domains protein 8 (sprot)

description: A multiple epidermal growth factor-like domains protein 8 that is encoded in the genome of human.


name: NR4A3_HUMAN Nuclear receptor subfamily 4 group A member 3 (sprot)

description: A nuclear receptor subfamily 4 group A member 3 that is encoded in the genome of human.


okadaic acid

A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish.  A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.


name: NK3R_HUMAN Neuromedin-K receptor (sprot)

description: A neuromedin-K receptor that is encoded in the genome of human.


venlafaxine

A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-methoxyphenyl group.


name: MYL6_HUMAN Myosin light polypeptide 6 (sprot)

description: A myosin light polypeptide 6 that is encoded in the genome of human.


name: ADCK2_HUMAN Uncharacterized aarF domain-containing protein kinase 2 (sprot)

description: An uncharacterized aarF domain-containing protein kinase 2 that is encoded in the genome of human.


name: SMAD7_HUMAN Mothers against decapentaplegic homolog 7 (sprot)

description: A smad7 that is encoded in the genome of human.


name: IL6RA_HUMAN Interleukin-6 receptor subunit alpha (sprot)

description: An interleukin-6 receptor subunit alpha that is encoded in the genome of human.


acute pyelonephritis

description: Sudden onset pyelonephritis.


entecavir

Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B.


childhood bladder carcinoma

description: A rare carcinoma of the bladder that occurs during childhood.


zileuton

A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma.


name: ERBB3_HUMAN Receptor tyrosine-protein kinase erbB-3 (sprot)

description: A receptor tyrosine-protein kinase erbB-3 that is encoded in the genome of human.


sevoflurane

An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.


name: NUAK1_HUMAN NUAK family SNF1-like kinase 1 (sprot)

description: A NUAK family SNF1-like kinase 1 that is encoded in the genome of human.


name: PA2G3_HUMAN Group 3 secretory phospholipase A2 (sprot)

description: A group 3 secretory phospholipase A2 that is encoded in the genome of human.


name: PAI2_HUMAN Plasminogen activator inhibitor 2 (sprot)

description: A plasminogen activator inhibitor 2 that is encoded in the genome of human.


name: ST1A1_HUMAN Sulfotransferase 1A1 (sprot)

description: A sulfotransferase 1A1 that is encoded in the genome of human.


triamterene

Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.


name: FGF5_HUMAN Fibroblast growth factor 5 (sprot)

description: A fibroblast growth factor 5 that is encoded in the genome of human.


name: ZP2_HUMAN Zona pellucida sperm-binding protein 2 (sprot)

description: A zona pellucida sperm-binding protein 2 that is encoded in the genome of human.


name: GPR85_HUMAN Probable G-protein coupled receptor 85 (sprot)

description: A probable G-protein coupled receptor 85 that is encoded in the genome of human.


name: SCN9A_HUMAN Sodium channel protein type 9 subunit alpha (sprot)

description: A sodium channel protein type 9 subunit alpha that is encoded in the genome of human.


ASIATIC ACID

A pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3 and 23 (the 2alpha,3beta stereoisomer). It is isolated from Symplocos lancifolia and Vateria indica and exhibits anti-angiogenic activity.


hypertensive nephropathy

description: Kidney damage that results from chronically elevated blood pressure; complications include glomerular damage resulting in proteinuria and hematuria.


uveal melanoma

description: A melanoma derived from melanocytes of the uveal tract. It is the most common primary intraocular tumor in the United States and Western Europe. Similar to melanoma of the skin, it is rare in Africa and Asia. Diagnostic procedures include ophthalmoscopic exam, fluorescein angiography and ultrasound. Treatment includes: surgical excision of the eye, iridocyclectomy and tumor resection. Recent treatments also include radiotherapy or photo coagulation. Classification of uveal melanomas recognizes four cell types within these tumors: epithelioid, intermediate, mixed cell, and spindle cell types. The spindle cell type uveal melanomas are further sub-classified as spindle cell type A and spindle cell type B.


name: MAF1_HUMAN Repressor of RNA polymerase III transcription MAF1 homolog (sprot)

description: A repressor of RNA polymerase III transcription MAF1 that is encoded in the genome of human.


PRDX2_HUMAN Peroxiredoxin-2 (sprot)

A peroxiredoxin-2 that is encoded in the genome of human.


xylazine

A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.


aspiration pneumonia

description: A type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper respiratory tract.


dapagliflozin

A C-glycosyl comprising beta-D-glucose in which the anomeric hydroxy group is replaced by a 4-chloro-3-(4-ethoxybenzyl)phenyl group. Used (in the form of its propanediol monohydrate) to improve glycemic control, along with diet and exercise, in adults with type 2 diabetes.


Dyspnea

description: Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale.


name: TRIM7_HUMAN E3 ubiquitin-protein ligase TRIM7 (sprot)

description: An E3 ubiquitin-protein ligase TRIM7 that is encoded in the genome of human.


name: PEDF_HUMAN Pigment epithelium-derived factor (sprot)

description: A pigment epithelium-derived factor that is encoded in the genome of human.


L-tyrosine

An optically active form of tyrosine having L-configuration.


ADM2_HUMAN Protein ADM2 (sprot)

A protein ADM2 that is encoded in the genome of human.


MUC1_HUMAN Mucin-1 (sprot)

A mucin-1 that is encoded in the genome of human.


name: HMGA1_HUMAN High mobility group protein HMG-I/HMG-Y (sprot)

description: A high mobility group protein HMG-I/HMG-Y that is encoded in the genome of human.


name: KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 (sprot)

description: A ribosomal protein S6 kinase alpha-3 that is encoded in the genome of human.


captopril

A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.


name: RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase (sprot)

description: A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human.


etodolac

A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.


PRS23_HUMAN Serine protease 23 (sprot)

A serine protease 23 that is encoded in the genome of human.


omipalisib

A member of the class of quinolines that is quinoline which is substituted by pyridazin-4-yl and 5-[(2,4-difluorobenzene-1-sulfonyl)amino]-6-methoxypyridin-3-yl groups at positions 4 and 6, respectively. It is a highly potent inhibitor of PI3K and mTOR developed by GlaxoSmithKline and was previously in human phase 1 clinical trials for the treatment of idiopathic pulmonary fibrosis and solid tumors.


cutaneous lupus erythematosus

description: An autoimmune disorder that manifests as different lupus-specific skin disorders; it can occur with systemic lupus erythematosus, or as a singular disease.


DIALLYLDISULFIDE

An organic disulfide where the organic group specified is allyl. It has been isolated from garlic and other species of the genus Allium.


KPYR_HUMAN Pyruvate kinase PKLR (sprot)

A pyruvate kinase PKLR that is encoded in the genome of human.


name: HDAC9_HUMAN Histone deacetylase 9 (sprot)

description: A histone deacetylase 9 that is encoded in the genome of human.


binimetinib

A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM). Approved by the FDA for the  treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib.


tuberous sclerosis 2

description: Tuberous sclerosis mapped to chromosome 16p13.3 (TSC2 gene).


name: HESX1_HUMAN Homeobox expressed in ES cells 1 (sprot)

description: A homeobox expressed in ES cells 1 that is encoded in the genome of human.