name: Prolonged depressive adjustment reaction

description: Temporary but prolonged and maladaptive depressive signs and symptoms associated with a life event.


Recurrent Paraganglioma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: The reemergence of paraganglioma after a period of remission.


Microabscess

description: A very small, tiny abscess.


name: Moderately Differentiated Prostate Adenocarcinoma

description: An invasive prostate adenocarcinoma characterized by the presence of malignant cells exhibiting moderate differentiation.


Acute pulmonary embolism

description: An acute embolism to the pulmonary vasculature.


Very Severe Aplastic Anemia

description: Aplastic anemia that is characterized by bone marrow (BM) cellularity less than 25% (or less than 50% if BM is comprised of less than 30% hematopoietic cells), and two or more of the following: absolute neutrophil count of less than 200 per microliter; platelet count of less than 20,000 per microliter; or an absolute reticulocyte count of less than 20,000 per microliter.


Cerebrovascular Insufficiency

description: A condition resulting in inadequate blood flow through the blood vessels supplying the brain, due to intrinsic disease of the vasculature.


Appendix Neuroendocrine Tumor G3

description: A neuroendocrine tumor grade 3 that arises from the appendix.


Leukemia recurrent

description: The reemergence of leukemia after a period of remission.


Metastatic Non-Cutaneous Melanoma

description: A non-cutaneous melanoma that has spread from its original site of growth to another anatomic site.


Refractory Esophageal Carcinoma

description: Esophageal carcinoma that is resistant to treatment.


name: Non-Neoplastic, Non-Molar Gestational Trophoblastic Disorder

description: A category of non-neoplastic gestational trophoblastic disorders that includes the exaggerated placental site reaction and placental site nodule or plaque. It does not include hydatidiform mole.


Conjunctival Carcinoma

description: A carcinoma that arises from the conjunctiva.


Esophageal Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Placental aromatase deficiency

description: An autosomal recessive condition that results in aromatase deficiency in the placenta, causing temporary virilization of the pregnant woman and virilization of her 46,XX fetus.


name: Invasive Large Nested Urothelial Carcinoma

description: A rare invasive urothelial carcinoma characterized by the presence of medium to large nests of malignant cells.


Refractory Malignant Germ Cell Tumor

description: Malignant germ cell tumor resistant to treatment.


Refractory Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that does not respond to treatment.


Non-Neoplastic Breast Disorder

description: A non-neoplastic disorder that affects the breast. Representative examples include fibrocystic disease, gynecomastia, mastitis, and adenosis.


High Grade Intraepithelial Neoplasia

description: A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as grade II (moderate dysplasia) or grade III (severe dysplasia).


Refractory Adenovirus Infection

description: An adenovirus infection that does not respond to treatment.


name: Unresectable Renal Pelvis and Ureter Urothelial Carcinoma

description: Renal pelvis and ureter urothelial carcinoma that is not amenable to surgical resection.


Refractory Acute Lymphoblastic Leukemia

description: Acute lymphoblastic leukemia that does not respond to treatment.


name: Human Papillomavirus-Independent Cervical Adenocarcinoma In Situ

description: Cervical adenocarcinoma in situ not associated with human papillomavirus infection.


name: Musculoskeletal Chest Pain due to Myositis

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A condition in which there is musculoskeletal chest pain secondary to inflammation of the muscle tissue. (ACC/AHA)


name: Hematologic Neoplasm with Germline ANKRD26 Mutation

description: An autosomal dominant disorder characterized by moderate thrombocytopenia and increased risk of developing myelodysplastic syndrome/acute myeloid leukemia. This disorder is characterized by germline mutations in ANKRD26, located on chromosome band 10p12.1. (WHO 2017)


Early Unfavorable Hodgkin Lymphoma

description: An early Hodgkin lymphoma with unfavorable prognosis.


Stage IIB Appendix Carcinoma AJCC v7

description: Stage IIB includes: T4a, N0, M0. T4a: Tumor penetrates visceral peritoneum including mucinous peritoneal tumor within the right lower quadrant.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Fetus in fetu

description: An exceptionally rare congenital abnormality in which a malformed and parasitic fetus is located within the body of its twin.


name: Endometrioid adenocarcinoma, ciliated cell variant

description: An endometrioid adenocarcinoma arising from the endometrium, in which ciliated cells line the majority of the malignant glands.


Adult Acute Myeloblastic Leukemia

description: An acute myeloid leukemia occurring in adults.


name: Infection and inflammatory reaction due to internal orthopedic fixation device

description: An infectious process involving an implanted medical device and the surrounding tissues.


Nonorganic Insomnia

description: Insomnia as a result of an extrinsic cause.


Penile Pain

description: Painful sensation in the penis.


name: EBV-Related Lymphoproliferative Disease with Primary Immunodeficiency

description: An EBV-related lymphoid proliferation that arises in the setting of immune deficiency due to a primary immunodeficiency or immunoregulatory disorder.


name: Low Grade Anal Canal Intraepithelial Neoplasia

description: Intraepithelial neoplasia involving the anal canal.  The epithelial cells exhibit mild dysplasia (grade I intraepithelial neoplasia).


Osteosarcoma recurrent

description: The reemergence of osteosarcoma after a period of remission.


name: Acute Myeloid Leukemia with In-Frame bZIP CEBPA Mutation

description: An acute myeloid leukemia characterized by the presence of CEBPA bZIP domain mutation. It is associated with a favorable clinical outcome.


IgD Monoclonal Gammopathy

description: An abnormal laboratory test result indicating the presence of IgD monoclonal immunoglobulin in the blood or urine.


name: Stage II Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

description: Stage II includes: T2, N0, M0. T2: Pheochromocytoma measuring 5 cm or more in greatest dimension or paraganglioma-sympathetic of any size, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Antenatal Hydronephrosis

description: Hydronephrosis that occurs in a fetus.


Malignant Proliferating Pilar Tumor

description: A rare malignant neoplasm that arises from the outer root sheath of the hair follicle. It usually occurs in the scalp, face and trunk. Histopathology shows cords of malignant squamous cells infiltrating into the dermis.


Stage IB Bone Cancer AJCC v7

description: Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


name: Platinum-Resistant Malignant Germ Cell Tumor

description: A malignant germ cell tumor that is resistant to platinum therapy.


name: Adult Unfavorable Prognosis Hodgkin Lymphoma

description: A Hodgkin lymphoma with unfavorable prognosis that occurs during adulthood.


Mycotic pericarditis

description: Pericarditis that is caused by an infection with a fungal agent.


name: Metastatic malignant neoplasm to conjunctiva

description: A malignant neoplasm that has spread to the conjunctiva from another anatomic site.


name: Anaplastic (Malignant) Intracranial Meningioma

description: An anaplastic meningioma that arises within the cranial cavity.


name: Hereditary factor XII deficiency disease

description: A rare autosomal recessive inherited bleeding disorder caused by deficiency of coagulation factor XII. It may be asymptomatic or manifest with bleeding.


Metastatic Vaginal Carcinoma

description: A carcinoma that arises from the vagina and has metastasized to another anatomic site.


name: Osteoclastic Giant Cell-Rich Tumor of Bone

description: A benign, intermediate, or malignant bone tumor characterized by the presence of osteoclast-like giant cells. Clinical presentation includes pain, edema, and decreased range of motion in the affected joint.


Metastatic endometrioid carcinoma

description: An endometrioid adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IVA includes: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Recurrent Malignant Neoplasm of Multiple Primary Sites

description: Reemergence of a malignant neoplasm of multiple primary sites after a period of remission.


name: Breast Fibrocystic Change, Proliferative Type without Atypia

description: Breast fibrocystic change characterized by the presence of epithelial cell hyperplasia.  There is no evidence of epithelial atypia.


Cervical Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm that arises from the cervix.


Granular Cell Astrocytoma

description: An astrocytoma characterized by the presence of large numbers of neoplastic cells with granular, PAS-positive cytoplasm. It is associated with an aggressive clinical course, even when the histologic features suggest a lower-grade astrocytoma.


name: High Grade Conjunctival Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process with high-grade dysplastic features involving the conjunctival epithelium.


name: Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage II includes: IIA: T1, N1, M0; IIB: T2, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Nuclear Cataract Grade 2

description: A stage of nuclear sclerotic cataract marked by moderate yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Retinoblastoma, undifferentiated

description: A retinoblastoma composed of small, undifferentiated cells. It is often associated with necrotic changes.


Stage IIC Prostate Cancer AJCC v8

description: Stage IIC includes: (T1-2, N0, M0, PSA less than 20, Grade Group 3); (T1-2, N0, M0, PSA less than 20, Grade Group 4). T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


Delusional disorder, somatic type

description: A subtype of delusional disorder characterized by the central delusional theme that the individual has some physical defect or medical condition.


name: T Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

description: T-lymphoblastic leukemia/lymphoma in which further genetic/molecular characterization is not available.


Bladder Paraganglioma

description: An extra-adrenal sympathetic paraganglioma arising from the urinary bladder.  Clinical signs include hypertension and hematuria.


name: Childhood Malignant Genitourinary System Neoplasm

description: A malignant neoplasm that affects the genitourinary system during childhood.


Broad Ligament Serous Adenocarcinoma

description: A rare serous adenocarcinoma that arises from the broad ligament.


name: Vaginal Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the vagina and is characterized by the presence of keratin pearls. Intercellular bridges and cytoplasmic keratinization are usually present.


Cutaneous neurofibroma

description: A neurofibroma that grows along small branches of nerves in the dermis in patients with neurofibromatosis. It presents as a solid cutaneous tumor.


Esophageal adenocarcinoma recurrent

description: An esophageal adenocarcinoma which has reappeared after a period of remission or after presumed treatment.


Cervical Cancer by AJCC v7 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 7th edition.


Acute Myocardial Injury

description: Acute myocardial injury diagnosed by rise and fall in cardiac troponin above the 99th percentile of a reference population.


Stage IIA1 Cervical Cancer AJCC v9

description: Stage IIA1 includes: T2a1, N0, M0. T2a1: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion measuring 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Conjunctival Spitz Nevus

description: A rare nevus that arises from the conjunctiva. It is characterized by the presence of large spindle-shaped or epithelioid melanocytes.


Prostate Undifferentiated Carcinoma

description: An invasive prostate carcinoma characterized by the presence of undifferentiated malignant cells.


Actinomycotic granuloma

description: A granuloma that develops in response to Actinomycotic fungal infection.


Refractory Liposarcoma

description: Liposarcoma that does not respond to treatment.


Stage IV Cervical Cancer AJCC v6 and v7

description: Stage IV includes: IVA: (T4, Any N, M0); IVB (Any T, Any N, MI). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M1: Distant metastasis. (AJCC 6th and 7th eds.)


Anaplastic Astroblastoma, MN1-Altered

description: An astroblastoma, MN1-altered, characterized by the presence of high mitotic activity, cytologic atypia, and architectural distortion.


Refractory Appendix Carcinoma

description: Appendix carcinoma that is resistant to treatment.


Critical illness myopathy

description: Acute muscle weakness and paralysis that develops in critically ill patients who have been treated with multiple drugs during their intensive care unit stay. It is associated with delayed weaning from mechanical ventilation and prolonged rehabilitation.


name: Lugano Classification Limited Stage Adult Lymphoma AJCC v8

description: Limited stage adult lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


name: Childhood Acute Lymphoblastic Leukemia CNS 2 Toronto Guidelines v2

description: No clinical signs of CNS involvement and blasts in CSF and either: WBC < 5/μL CSF or WBC > or = 5/uL CSF and RBC > or = 10/uL CSF and WBC/RBC in CSF < or = 2x WBC/RBC in blood. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage IIIC Appendix Carcinoma AJCC v8

description: Stage IIIC includes: Any T, N2, M0. N2: Four or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


description: Trigeminal neuralgia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Sensory Disorders

description: An interruption or alteration in the sensory activity or functions of the nervous system.


Metastatic Merkel Cell Carcinoma

description: A Merkel cell carcinoma that has spread from the original site of growth to another anatomic site.


Endometrial Neuroendocrine Carcinoma

description: A small cell or large cell neuroendocrine carcinoma arising from the endometrium.


name: Ampullary Flat Intraepithelial Neoplasia, High Grade

description: A non-polypoid, preinvasive neoplasm that arises from the ampulla of Vater.  It is characterized by the presence of high grade dysplasia.


name: Chronic Ocular Graft Versus Host Disease

description: Chronic graft versus host disease occurring in the eye.


Esophageal Basal Cell Hyperplasia

description: A reactive (non-neoplastic) hyperplastic process affecting the esophageal squamous epithelium that is caused by inflammation.  Morphologically it involves more than 15% of the thickness of the esophageal squamous epithelium.  Its association with an increase risk of developing squamous cell carcinoma remains controversial.


name: Pathologic Stage IIIA Cutaneous Melanoma AJCC v8

description: Stage IIIA includes: T1a/b-T2a, N1a or N2a, M0. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Diffuse Midline Glioma

description: A diffuse glioma that arises from the midline structures of the central nervous system. The majority of these tumors are found in the brainstem.


name: Unresectable Gastroesophageal Junction Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the gastroesophageal junction and is not amenable to surgical resection.


name: Adult Acute Myeloid Leukemia without Maturation

description: An acute myeloid leukemia without maturation occurring in adults.


Advanced Angiosarcoma

description: An angiosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Basal Cell Carcinoma

description: Basal cell carcinoma that is not amenable to surgical resection.


anaplastic carcinoma of urethra

description: An undifferentiated carcinoma arising from the urethra.


Conjunctival Blue Nevus

description: A benign melanocytic neoplasm that arises from the conjunctiva. It is characterized by the presence of dendritic and spindle-shaped melanocytes in the subepithelial connective tissue. It presents as a dark brown or black, slightly elevated conjunctival lesion.


Bilateral anophthalmos of eyes

description: A rare congenital abnormality characterized by the complete absence of ocular tissue in both orbits.


name: acute megakaryoblastic leukemia in relapse

description: The reemergence of acute megakaryoblastic leukemia after a period of remission.


name: Childhood Retinoblastoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood retinoblastoma according to the Toronto childhood cancer staging guidelines v2.


Localized Lymphoma

description: A lymphoma that is confined to a specific site without evidence of spread to other anatomic sites.


name: Advanced Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: Extrapulmonary large cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage III Renal Pelvis and Ureter Cancer AJCC v7

description: Stage III includes: T3, N0, M0. T3: For renal pelvis only: tumor invades beyond muscularis into peripelvic fat or the renal parenchyma.  For ureter only: tumor invades beyond muscularis into periureteric fat.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Anal cancer recurrent

description: The reemergence of anal carcinoma after a period of remission.


Gender identity disorder

description: A disorder characterized by a strong and persistent cross-gender identification (such as stating a desire to be the other sex or frequently passing as the other sex) coupled with persistent discomfort with his or her sex (manifested in adults, for example, as a preoccupation with altering primary and secondary sex characteristics through hormonal manipulation or surgery).


Thoracic Meningocele

description: A congenital abnormality in the thoracic region of the spine in which the meninges protrude through a defect in the spinal column.


name: Unresectable Glioneuronal and Neuronal Tumors

description: Glioneuronal and neuronal tumors that are not amenable to surgical resection.


name: Refractory Endometrial Clear Cell Adenocarcinoma

description: Endometrial clear cell adenocarcinoma that is resistant to treatment.


name: Locally Advanced Extrapulmonary Neuroendocrine Carcinoma

description: Extrapulmonary neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Reflux

description: An abnormal backward flow of a body fluid.


Infant T Acute Lymphoblastic Leukemia

description: A T-acute lymphoblastic leukemia that occurs in infancy.


Metastatic Urethral Carcinoma

description: A urethral carcinoma that has spread to another anatomical site.


name: FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting 6-50% solid non-glandular, non-squamous growth.


name: Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia

description: Acute myeloid leukemias arising as a result of the mutagenic effect of therapeutic agents targeting DNA-topoisomerase II. The vast majority of patients present without a preceding myelodysplastic phase. The acute myeloid leukemias are usually of the monoblastic or myelomonocytic type. Clonal cytogenetic abnormalities are frequently present and usually involve chromosome 11q23 (MLL gene).


Refractory Mucosal Melanoma

description: Mucosal melanoma that is resistant to treatment.


Glucokinase-Associated Hyperinsulinism

description: Hyperinsulinism due to activating mutation(s) in the gene GCK, encoding glucokinase.


Childhood Grade I Meningioma

description: A grade I meningioma that occurs during childhood.


name: Stage 0 Childhood Retinoblastoma by Toronto Guidelines v2

description: The tumor is confined to the globe. Enucleation has not been performed. (The patient is treated "conservatively" with either focal therapies or chemotherapy.) (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Astroblastoma, MN1-Altered

description: An astroblastoma, MN1-altered that occurs during childhood.


Stage IIIA Prostate Cancer AJCC v8

description: Stage IIIA includes: T1-2, N0, M0, PSA 20 or more, Grade Group 1-4; T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


name: Invasive Bladder Conventional Urothelial Carcinoma

description: Invasive bladder urothelial carcinoma characterized by the presence of malignant cells forming trabeculae, cords, sheets, and nests. Individual malignant cells are also present.


FNCLCC Sarcoma Grade 1

description: A sarcoma with a total score of 2 or 3 according to the FNCLCC guidelines.


Refluxing Megaureter

description: A megaureter that demonstrates retrograde urine flow without ureteral obstruction.


Meningothelial Hamartoma

description: A hamartoma characterized by the presence of collections of non-neoplastic arachnoidal cells.


name: Malignant urinary tract neoplasm metastatic

description: The spread of a malignant neoplasm to the urinary tract from an adjacent or distant anatomic site.


transvestism

description: A disorder characterized by recurrent sexual urges, fantasies, or behaviors in a heterosexual male involving cross-dressing.


name: adenocarcinoma of gallbladder with squamous metaplasia

description: An infiltrating adenocarcinoma of the gallbladder characterized by the presence of metaplastic changes of the malignant glandular cells to squamous cells.


Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for Hodgkin lymphomas based on the Ann Arbor classification criteria.


Complicated malaria

description: Acute malaria with signs of organ dysfunction, severe anemia (hemoglobin less than 5 g/dL or hematocrit less than 15%) and/or hyperparasitemia (greater than 5% of red blood cells infected).


name: Papillary transitional cell carcinoma, non-invasive

description: A transitional cell carcinoma characterized by a papillary growth pattern and lack of stromal invasion.


name: High Grade Prostatic Intraepithelial Neoplasia, Inverted Variant

description: High grade prostatic intraepithelial neoplasia characterized by the presence of secretory cells with their nuclei polarized towards the lumen of the glands.


Non-Neoplastic Conjunctival Disorder

description: A non-neoplastic disorder that affects the conjunctiva.


Unresectable Bladder Carcinoma

description: Bladder carcinoma that is not amenable to surgical resection.


Stage IV Prostate Cancer AJCC v7

description: Stage IV includes: (T4, N0, M0, Any PSA, Any Gleason); (Any T, N1, M0, Any PSA, Any Gleason); (Any T, Any N, M1, Any PSA, Any Gleason). cT4: Tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall.  pT4: Invasion of rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 7th ed.)


name: Diffuse Low Grade Glioma, BRAF p.V600E-Mutant

description: Diffuse low-grade glioma characterized by the presence of BRAF gene mutations encoding a p.V600E substitution mutation.


name: Pathologic Stage IIIB Cutaneous Melanoma AJCC v8

description: Stage IIIB includes: (T0, N1b, N1c, M0); (T1a/b-T2a, N1b/c or N2b, M0); (T2b/T3a, N1a-N2b, M0). T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration.  T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Recurrent Brain Neoplasm

description: The reemergence of a brain neoplasm after a period of remission.


description: A myelodysplastic/myeloproliferative neoplasm that is resistant to treatment.


Radiation-Induced Cancer

description: A malignant neoplasm arising in a site exposed to radiation therapy.


Vulvar Blue Nevus

description: A benign nevus that arises from the vulva and is characterized by the presence of heavily pigmented dendritic melanocytes exclusively in the dermis.


Weight Change

description: An increase or decrease in the weight of an individual.


Gonadal Thrombosis

description: Formation of a blood clot (thrombus) in the lumen of the vein that carries blood away from the testis or ovary.


Stage IIIB Testicular Cancer AJCC v8

description: Stage IIIB includes: (Any pT/TX, N1-3, M0, S2); (Any pT/TX, Any N, M1a, S2). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. M1a: Testicular cancer with non-retroperitoneal nodal or pulmonary metastases. S2: LDH 1.5-10 x N or hCG (mlU/mL) 5,000-50,000 or AFP (ng/mL) 1,000-10,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Goblet Cell Adenocarcinoma

description: A rare adenocarcinoma that exhibits neuroendocrine differentiation and is associated with the presence of neoplastic signet-ring cells resembling goblet cells of the intestine.


Transplant-Related Carcinoma

description: A carcinoma that arises in a patient with a history of organ transplantation.


Stage IA2 Cervical Cancer AJCC v9

description: Stage IA2 includes: T1a2, N0, M0. T1a2: Tumor with measured stromal invasion of more than 3.0 mm and equal or less than 5.0 mm in depth. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Duodenal fistula

description: An abnormal communication between the duodenum and another organ or cavity.


Stage I Gallbladder Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or muscular layer. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Hematologic Malignancy

description: The reemergence of a hematologic malignancy after a period of remission.


Stage II Adult Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Hemoglobin Lepore Syndrome

description: A beta thalassemia resulting from an unequal crossover/recombination event involving portions of the delta and beta globin genes, resulting in underproduction of the abnormal delta-beta globin.


name: Unresectable Pancreatic Neuroendocrine Tumor

description: Pancreatic neuroendocrine tumor that is not amenable to surgical resection.


Lupus Flare

description: An exacerbation of the chronic disease lupus.


Palisaded encapsulated neuroma

description: A benign peripheral nerve sheath tumor characterized by the presence of Schwann cells, axons, and perineurial fibroblasts.  It usually arises from the skin of the head and neck or the oral mucosa.  It presents as a solitary and painless nodular mass.


Refractory Meningioma

description: Meningioma that is resistant to treatment.


name: Mental and Behavioral Signs and Symptoms

description: Clinical evidence of disease resulting from mental and/or behavioral dysfunction.


Staphylococcal enterocolitis

description: Gastroenteritis resulting from an infection with Staphylococcus aureus.


Advanced Carcinoma

description: Carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage II Cervical Cancer AJCC v9

description: Stage II includes: T2, N0, M0. T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Pathologic Stage IIIC Cutaneous Melanoma AJCC v8

description: Stage IIIC includes: (T0, N2b, N2c, N3b or N3c); (T1a-T3a, N2c or N3a/b/c, M0); (T3b/T4a, Any N greater than or equal to N1, M0); (T4b, N1a-N2c, M0). T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N2c: One clinically occult nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Localized Non-Muscle Invasive Bladder Urothelial Carcinoma

description: A bladder urothelial carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites, and has not invaded the bladder muscularis propria.


Epilepsy aggravated

description: An increase in the duration or intensity of epileptic symptoms in the setting of chronic epilepsy.


name: Epithelioid Hemangioendothelioma with YAP1-TFE3 Gene Fusion

description: Epithelioid hemangioendothelioma characterized by a YAP1-TFE3 gene fusion. This gene fusion occurs in a subset of epithelioid hemangioendotheliomas characterized by the presence of well-formed vessels lined by epithelioid endothelial cells with abundant eosinophilic cytoplasm. Patients with YAP1-TFE3 gene fusion tumors tend to be younger than those with a WWTR1-CAMTA1 gene fusion.


name: Neoantigen-Positive Malignant Solid Neoplasm

description: A malignant solid neoplasm characterized by the expression of antigens resulting from cancer-specific mutations (neoantigens).


name: Lugano Classification Stage IIE Adult Hodgkin Lymphoma AJCC v8

description: Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


name: Femoral Hernia with Obstruction without Mention of Gangrene

description: The protrusion of contents of the abdominal cavity, into the femoral canal, which results in obstruction of intestinal peristalsis, with no mention of necrosis of the herniated contents.


Refractory Ependymoma

description: Ependymoma that does not respond to treatment.


Bodily Pain

description: The sensation of acute or chronic suffering in a body region.


Stage II Osteosarcoma AJCC v7

description: Stage II includes: IIA (T1, N0, M0, G3, G4); IIB (T2, N0, M0, G3, G4).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Metastatic Malignant Neoplasm in the Genitourinary System

description: The spread of a malignant neoplasm to the genitourinary system from an adjacent or distant anatomic site.


Disruptive mood dysregulation disorder

description: A condition in which children or adolescents experience irritability, anger, and intense temper outbursts. The episodes may be frequent and may eventually impact functioning at school, at home or with peers.


Mild Cardiac Valve Regurgitation

description: Evidence of mild retrograde blood flow through the valve(s) of the heart. (ACC)


name: Benign Mixed Epithelial and Mesenchymal Hair Follicle Neoplasm

description: A trichoblastoma characterized by the presence of neoplastic epithelial cells forming cribriform patterns.


Stage IV Vulvar Cancer AJCC v7

description: Stage IV includes: IVA: (T1/T2, N3, M0); (T3, Any N, M0); IVB: (Any T, Any N, M1).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  T3: Vulvar cancer with tumor of any size with extension to any of the following: upper/proximal 2/3 urethra, upper/proximal 2/3 vagina, bladder mucosa, rectal mucosa, or fixed to pelvic bone.  N3: Vulvar cancer with fixed or ulcerated regional lymph node metastasis.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 7th ed.)


name: Stage IV Anal Canal Cancer AJCC v6 and v7

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th and 7th Eds.)


name: Radiating Chest Pain Along Left Upper Sternal Border

description: The location of the radiating chest pain is along the left upper sternal border.


name: Acute Myeloid Leukemia with t(3;8)(q26.2;q24); MYC, MECOM

description: An acute myeloid leukemia associated with t(3;8)(q26.2;q24) resulting in MYC and MECOM rearrangement.


name: Hematologic Neoplasm with Germline Predisposition without a Constitutional Disorder Affecting Multiple Organ Systems

description: Familial hematologic neoplasms associated with germline mutations without a preexisting disorder or organ dysfunction.


Chronic pulmonary aspergillosis

description: A spectrum of disorders associated with long-term Aspergillus infection of the lung that usually occur in immunocompetent individuals with underlying respiratory disorders, and may be characterized by pulmonary fibrosis or cavitation.


name: Advanced Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: Extrapulmonary small cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Unresectable Digestive System Adenocarcinoma

description: An adenocarcinoma that arises from the gastrointestinal system and is not amenable to surgical resection.


Acquired kyphosis

description: Kyphosis, the cause of which is not present at birth.


name: COVID-19-Associated Nervous System Disorder

description: A central or peripheral nervous system disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Lower Abdominal Pain

description: A sensation of discomfort emanating from the inferior quadrants of the abdomen, which may be peritoneal or visceral in origin, or referred from an extra-abdominal location.


name: Coronary Artery Ectasia Related to COVID-19

description: Coronary artery ectasia in a patient with probable or confirmed acute COVID-19.


Childhood Pleomorphic Xanthoastrocytoma

description: A pleomorphic xanthoastrocytoma that occurs during childhood.


name: Congenital abnormality of respiratory system

description: An abnormality of the respiratory system that is present at birth or detected in the neonatal period.


Stage III Esophageal Cancer AJCC v7

description: Stage III includes: For squamous cell carcinoma: IIIA (T1-2, N2, M0, Any G, Tumor location: Any); (T3, N1, M0, Any G, Tumor location: Any); (T4a, N0, M0, Any G, Tumor location: Any); IIIB (T3, N2, M0, Any G, Tumor location: Any); IIIC (T4a, N1-2, M0, Any G, Tumor location: Any); (T4b, Any N, M0, Any G, Tumor location: Any); (Any T, N3, M0, Any G, Tumor location: Any).  For adenocarcinoma: IIIA (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G); IIIB (T3, N2, M0, Any G); IIIC (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Epididymal Papillary Cystadenoma

description: A cystadenoma that arises from the epididymis. It is characterized by the presence of small papillary projections in the inner surface of the cysts. It may be sporadic or associated with von Hippel-Lindau disease.


Advanced Basal Cell Carcinoma

description: Basal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IIB Bone Sarcoma AJCC v7

description: Stage IIB includes: T2, N0, M0, G3, G4.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Pathologic Stage IIA Cutaneous Melanoma AJCC v8

description: Stage IIA includes: (T2b, N0, M0); (T3a, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Circumscribed Meningeal Melanocytic Neoplasm

description: A circumscribed neoplasm that arises from leptomeningeal melanocytes. This category includes meningeal melanocytoma and meningeal melanoma.


First degree uterine prolapse

description: The uterus has descended above the hymen.


Stage III Uterine Corpus Cancer AJCC v6

description: Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Local and/or regional spread as defined below.  T3a: Tumor invades serosa and/or adnexa (direct extension or metastasis) and/or cancer cells in ascites or peritoneal washings.  T3b Vaginal involvement (direct extension or metastasis). N0: No regional lymph node metastasis. N1: Regional lymph node metastasis to pelvic and/or para-aortic nodes.  M0: No distant metastasis. (AJCC 6th ed.)


name: Stage M1 Childhood Ependymoma by Toronto Guidelines v2

description: Tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Human Papillomavirus-Independent Vaginal Squamous Cell Carcinoma

description: Vaginal squamous cell carcinoma not associated with human papillomavirus infection.


Stage IIA Cervical Cancer AJCC v9

description: Stage IIA includes: T2a, N0, M0. T2a: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Post-streptococcal reactive arthritis

description: The occurrence of arthritis after infection with group A streptococcus. It is non-migratory, protracted in course, and poorly responsive to anti-inflammatory agents. (from Textbook of Pediatric Rheumatology, 6th ed. Cassidy, Petty, Laxer, and Lindsley)


name: Refractory Female Reproductive System Carcinoma

description: Female reproductive system carcinoma that is resistant to treatment.


name: Low Grade Corneal Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process with low-grade dysplastic features involving the corneal epithelium.


name: Intraductal papillary neoplasm with high grade intraepithelial neoplasia

description: An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts. It is characterized by the presence of severe epithelial atypia.


Nuclear Cataract Grade 3

description: A stage of nuclear sclerotic cataract marked by pronounced yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


name: Platinum-Sensitive Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that has a documented response to platinum-based chemotherapy.


Gastric mucositis

description: An inflammatory process affecting the mucous membrane of the stomach.


name: Stage IVA Cervical Cancer AJCC v6 and v7

description: Stage IVA includes: T4, Any N, M0). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (AJCC 6th and 7th eds.)


Benign neoplasm of lacrimal apparatus

description: A neoplasm that arises from the lacrimal gland or lacrimal drainage system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Hyalinizing Clear Cell Carcinoma

description: A rare, slow-growing carcinoma characterized by the presence of malignant clear and eosinophilic cells in a hyalinized stroma. It has been described in the salivary glands and lung. Most cases are associated with translocation of EWSR1 and ATF1, resulting in the formation of EWSR1-ATF1 fusion gene. The prognosis is good.


Lumbar myelocele

description: Herniation of spinal cord tissue and meninges through a defect in the lumbar region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


name: Metastatic Bladder Clear Cell (Glycogen-Rich) Urothelial Carcinoma

description: Bladder clear cell (glycogen-rich) urothelial carcinoma that has spread to another anatomic site.


Achromic nevus

description: A benign nevus characterized by the absence of melanin pigment in the melanocytes.


Papillary neoplasm

description: A benign, intermediate, or malignant neoplasm characterized by the formation of papillary structures.


name: Childhood Langerhans Cell Histiocytosis without Risk Organ Involvement

description: Langerhans cell histiocytosis that occurs during childhood and does not involve the bone marrow, spleen, liver, or lung.


Esophageal adenocarcinoma stage IV

description: An adenocarcinoma that arises from the esophagus and has metastasized to another anatomic site.


Destructive Arthritis

description: Arthritis associated with the destruction of the cartilage and the articular surface of the bone of the joint. This process severely interferes with movement in the joint.


Lymphoma by Ann Arbor Stage

description: An anatomic stage for Hodgkin and non-Hodgkin lymphomas  based on the Ann Arbor classification criteria.


Bilateral glaucoma

description: Increased pressure in both eyeballs due to obstruction of the outflow of aqueous humor.


name: Chest Pain Along Left Midclavicular Line

description: The location of the chest pain is along the left midclavicular line.


Recurrent Childhood Malignant Neoplasm

description: The reemergence of a childhood malignant neoplasm after a period of remission.


name: Locally Advanced Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Intercalated Duct Hyperplasia

description: A salivary ductal proliferation resembling intercalated ducts. (WHO 2017)


Childhood Diabetes Mellitus

description: Diabetes mellitus that develops during childhood.


name: Precursor T-lymphoblastic lymphoma/leukemia recurrent

description: The reemergence of T-lymphoblastic leukemia/lymphoma after a period of remission.


Vaginal Undifferentiated Carcinoma

description: A carcinoma that arises from the vagina and is characterized by the lack of specific cellular differentiation.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 5

description: Dyskeratosis congenita caused by mutation(s) in the RTEL1 gene, encoding regulator of telomere elongation helicase 1.


name: Musculoskeletal Chest Pain due to Costochondritis

description: A condition in which there is musculoskeletal chest pain associated with inflammation of one or more ribs and/or cartilages. (ACC/AHA)


name: Stage III Gestational Trophoblastic Neoplasm AJCC v8

description: Stage III includes: Any T, M1a. M1a: Gestational trophoblastic neoplasm with lung metastasis. (AJCC 8th Ed.)


name: Pathologic Stage IV Esophageal Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T4a, N2, M0, Any G); (T4b, N0-2, M0, Any G); (Any T, N3, M0, Any G); IVB: (Any T, Any N, M1, Any G). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Cutaneous Mature T-Cell and NK-Cell Neoplasm

description: A group of neoplasms composed of T-lymphocytes with a mature (peripheral/post-thymic) immunophenotypic profile and/or NK-cells affecting the skin.


Refractory Adenocarcinoma

description: An adenocarcinoma that does not respond to treatment.


EBV-Related Hodgkin Lymphoma

description: Hodgkin lymphoma that is caused by Epstein-Barr virus infection.


name: High Grade Pancreatic Intraepithelial Neoplasia

description: A pancreatic epithelial neoplasia characterized by the presence of papillary and rarely flat architectural patterns with formation of cribriform patterns and luminal necrosis.  Severe dysplasia is present.


Neuroendocrine carcinoma of appendix

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the appendix. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Hindgut Neuroendocrine Tumor G3

description: A neuroendocrine tumor grade 3 that arises from the sigmoid colon, descending colon, or rectum.


name: Locally Advanced Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Remote Placental Infarction

description: A focus of necrotic placental parenchyma with marked hyalinization and fibrosis with complete absence of the necrotic chorionic villi, which is frequently more than 7 days of duration.


name: Pathologic Stage IIA Esophageal Adenocarcinoma AJCC v8

description: Stage IIA includes: (T2, N0, M0, G3); (T2, N0, M0, GX). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Stage IIIB Bladder Cancer AJCC v8

description: Stage IIIB includes: T1-T4a, N2, N3, M0. T1: Tumor invades lamina propria (subepithelial connective tissue). T2: Tumor invades muscularis propria. T3: Tumor invades perivesical soft tissue. T4a: Extravesical tumor invades directly into prostatic stroma, uterus, vagina. N2: Multiple regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node metastasis). N3: Lymph node metastasis to the common iliac lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Acquired methemoglobinemia

description: Methemoglobinemia that is caused by exposure to certain drugs (xylocaine and benzene) and nitrate-rich foods.


Stage I Fallopian Tube Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Fallopian tube cancer with tumor limited to fallopian tube(s). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage I Vulvar Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IV Bladder Cancer AJCC v8

description: Stage IV includes: IVA: (T4b, N0, M0); (Any T, Any N, M1a); IVB: (Any T, Any N, M1b). T4b: Extravesical tumor invades pelvic wall, abdominal wall. N0: No regional lymph node metastasis. M0: No distant metastasis. M1a: Distant metastasis limited to lymph nodes beyond the common iliacs. M1b: Non-lymph node distant metastases. (AJCC 8th ed.)


Sharp Pain

description: A sensation of discomfort or distress that is distinct and intensely focused.


name: Helicobacter Pylori-Related Gastric Adenocarcinoma

description: An adenocarcinoma that arises from the gastric mucosa and is caused by persistent infection with Helicobacter pylori.


name: Locally Advanced Transitional Cell Carcinoma

description: Transitional cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Chemical esophagitis

description: Esophagitis secondary to chemical exposure.


name: Endocrine disorder arising from mental factors

description: An endocrine disorder that is caused by abnormal mental function.


Recurrent Childhood Oligodendroglioma

description: The reemergence of oligodendroglioma in childhood after a period of remission.


Familial Testicular Germ Cell Tumor

description: Germ cell tumor that arises from the testis and is diagnosed in at least two relatives.


Congenital hamartoma

description: A hamartomatous lesion which is present at birth.


Immune System and Related Disorders

description: A group of non-neoplastic and neoplastic disorders resulting from the deregulation and/or deficiency of immune system functions. It includes autoimmune disorders (e.g., lupus erythematosus, dermatomyositis, rheumatoid arthritis), congenital and acquired immunodeficiency syndromes including the acquired immune deficiency syndrome (AIDS), and neoplasms (e.g., lymphomas and malignancies secondary to transplantation).


name: Cervical Adenocarcinoma Admixed with Neuroendocrine Carcinoma

description: A carcinoma that arises from the cervix and is characterized by the presence of a cervical adenocarcinoma variant and a neuroendocrine carcinoma component.


name: Metastatic Malignant Neoplasm in the Visual Pathway

description: A malignant neoplasm that has spread to the visual pathway from another anatomic site.


Advanced Ampulla of Vater Carcinoma

description: Carcinoma that arises from the ampulla of Vater and has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Moderately Differentiated Malignant Neoplasm

description: A neoplasm whose histologic characteristics are intermediate between poorly differentiated and well differentiated.


Refractory Urothelial Carcinoma

description: Urothelial carcinoma that does not respond to treatment.


Nuclear Cataract Grade 1

description: A stage of nuclear sclerotic cataract marked by mild yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Adult Rhabdomyosarcoma

description: An aggressive malignant mesenchymal neoplasm arising from skeletal muscle in adults.


Paratesticular Endometrioid Tumor

description: A group of very rare tumors with endometrioid epithelial differentiation arising from the paratesticular structures. It includes benign tumors, borderline tumors (tumors with atypical epithelial proliferation), and malignant tumors (endometrioid adenocarcinomas).


name: Stage IVA Gestational Trophoblastic Tumor AJCC v7

description: Stage IVA includes: Any T, M1b, Risk factors: low risk.  M1b: All other distant metastasis.  (AJCC 7th ed.)


Refractory Malignant Glioma

description: Malignant glioma that does not respond to treatment.


name: Childhood Acute Lymphoblastic Leukemia Toronto Guidelines v2, Tier 2

description: A term that refers to the staging of childhood acute lymphoblastic leukemia according to the tier 2 Toronto childhood cancer staging guidelines v2.


Malignant Neoplasm by Grade

description: A term that refers to the categorization of malignant neoplasm by histologic grade.


Stage IIA Cervical Cancer FIGO 2009

description: Cervical carcinoma limited to the upper two-thirds of the vagina. (FIGO 2009)


Toxic polyneuropathy

description: Polyneuropathy that is caused by exposure to toxins.


Perinatal Brain Injury

description: Injury to the brain of a newborn infant occurring around the time of birth.


Vascular implant infection

description: An infectious process originating from an implanted vascular device.


Opisthorchis viverrini Infection

description: An infection caused by the parasite Opisthorchis viverrini. It results from the ingestion of raw or undercooked food. The clinical features vary from mild to severe and include gastrointestinal symptoms, anorexia, weight loss, hepatomegaly, and cholangitis. Patients are at an increased risk of developing cholangiocarcinoma.


name: Recurrent Fallopian Tube Undifferentiated Carcinoma

description: The reemergence of fallopian tube undifferentiated carcinoma after a period of remission.


Conjunctival Lymphangioma

description: A lymphangioma that arises from the conjunctiva.


perinatal respiratory distress

description: A pathological increase in the effort and frequency or breathing movements during the perinatal period.


Castleman Disease, Plasma Cell Type

description: Castleman disease characterized by the presence of prominent hyalinized vessels in the germinal centers and prominent sheets of plasma cells in the interfollicular areas.


name: Vaso-Occlusive Crisis in Sickle Cell-SS Disease

description: Sickle cell-SS disease exacerbated by sudden pain caused by sickled erythrocytes impeding blood flow within a vessel.


Gastric Mixed Adenocarcinoma

description: An adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of both glandular and poorly cohesive malignant cellular components.


Liposarcoma non-metastatic

description: Liposarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


Non-Neoplastic Disorder

description: Any disorder other than abnormal tissue growth resulting from uncontrolled cell proliferation.


name: Stage II Ampulla of Vater Neuroendocrine Tumor AJCC v8

description: Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor invading through the sphincter of Oddi into duodenal submucosa or muscularis propria, or measuring more than 1 cm. T3: Tumor invading the pancreas or peripancreatic adipose tissue. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Locally Advanced Midgut Neuroendocrine Tumor

description: A midgut neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Lugano Classification Stage II Bulky Childhood Hodgkin Lymphoma AJCC v8

description: Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


name: Central Nervous System Vascular Malformations

description: A congenital abnormality of the arteries and veins that is located in the brain or spina cord, and which may increase the risk of bleeding, possibly resulting in impaired mental or physical function.


name: Recurrent Male Reproductive System Carcinoma

description: The reemergence of a carcinoma that affects the male reproductive system after a period of remission.


name: Locally Advanced Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Childhood Benign Endocrine Neoplasm

description: A childhood epithelial neoplasm that arises from an endocrine organ and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Stage IA2 Cervical Cancer AJCC v8

description: Stage IA2 includes: T1a2, Any N, M0. T1a2: Invasive cervical carcinoma with measured stromal invasion of more than 3.0 mm and not more than 5.0 mm, with a horizontal spread of 7.0 mm or less. M0: No distant metastasis. (AJCC 8th Ed.)


Intracranial Melanoma

description: A melanoma that arises from the leptomeninges within the cranium.


name: Unresectable Primary Malignant Central Nervous System Neoplasm

description: A primary malignant central nervous system neoplasm that is not amenable to surgical resection.


name: Chest Pain in Right Third Intercostal Space

description: The location of the chest pain is within the third intercostal space on the right side.


Adnexitis

description: Inflammation of the appendages of the uterus.


name: Metastatic Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma that has spread to other anatomic sites.


Vulvar Cancer by AJCC v7 Stage

description: A term that refers to the staging of vulvar carcinoma according to the American Joint Committee on Cancer, 7th edition.


Genitourinary Cancer

description: A primary or metastatic malignant neoplasm that affects the genitourinary system.


COVID-19-Associated Thromboembolism

description: Thromboembolism caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Stage IV Gallbladder Cancer AJCC v8

description: Stage IV includes: IVA: T4, N0-1, M0; IVB: (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invading the main portal vein or hepatic artery or invading two or more extrahepatic organs or structures. N0: No regional lymph node metastasis. N1: Metastases to one to three regional lymph nodes. N2: Metastases to four or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Recurrent Neuroendocrine Neoplasm

description: The reemergence of a neuroendocrine neoplasm after a period of remission.


Obesity-Related Malignant Neoplasm

description: A malignant neoplasm that occurs in the context of obesity.


name: Renal Pelvis and Ureter Cancer by AJCC v7 Stage

description: A term that refers to the staging of renal pelvis and ureter cancer according to the American Joint Committee on Cancer, 7th edition.


Adult Acute Basophilic Leukemia

description: An acute basophilic leukemia occurring in adults.


Benign Genitourinary System Neoplasm

description: A neoplasm that arises from the genitourinary system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


X-Linked Dyskeratosis Congenita

description: Dyskeratosis congenita inherited in an X-linked recessive pattern. It is caused by mutations in the DKC1 gene.


Factor I Inactivation

description: Presence of inactivating antibodies to fibrinogen (factor I) in the blood.


Stage I Pancreatic Cancer AJCC v8

description: Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Frotteurism

description: A disorder characterized by recurrent sexual urges, fantasies, or behaviors involving touching the genitals of or rubbing the genitals against a nonconsenting person.


Cyst of Skene's duct

description: A rare benign lesion that arises from the vagina. It is characterized by the presence of squamous epithelial and tubular structures in a fibrovascular stroma.


Radiating Chest Pain in Lower Sternum

description: The location of the radiating chest pain is in the lower portion of the sternum.


Renal and perinephric abscess

description: An abscess that is located both in the kidney and across the renal capsule into the perinephric space.


name: Unresectable Fallopian Tube Adenocarcinoma

description: Fallopian tube adenocarcinoma that is not amenable to surgical resection.


name: Recurrent Platinum-Sensitive Fallopian Tube Carcinoma

description: The reemergence of platinum-sensitive fallopian tube carcinoma after a period of remission.


Polycythemia Vera, Polycythemic Phase

description: Polycythemia vera characterized by the proliferation of the erythroid, granulocytic, and megakaryocytic lineages. The peripheral blood shows excess of red blood cells, neutrophilia, and thrombocytosis. The bone marrow is hypercellular for the patient's age.


name: Adenocarcinoma in situ in tubulovillous adenoma

description: A non-invasive adenocarcinoma arising from a tubulovillous adenoma.


Cystic Trophoblastic Tumor

description: A rare trophoblastic neoplasm that arises in metastatic sites of testicular mixed germ cell tumors following chemotherapy, or is part of treated or untreated testicular mixed germ cell tumors, or is secondary to either chemotherapy-induced or spontaneous regression of testicular choriocarcinoma. It has also been described in central nervous system post-chemotherapy primary germ cell tumors. It is characterized by the presence of cysts lined by squamoid trophoblastic cells. The cysts are often compressed surrounded by other germ cell components.


name: Infectious mononucleosis-like post-transplant lymphoproliferative disorder

description: An early post-transplant lymphoproliferative lesion characterized by immunoblastic proliferation and paracortical expansion as seen in infectious mononucleosis.  There is architectural preservation of the involved tissues.  Oligoclonal or monoclonal cellular populations have been detected in a small number of cases.  In some cases, a polymorphic or monomorphic post-transplant lymphoproliferative disorder may follow this early lesion.


Recurrent Myxoid Liposarcoma

description: The reemergence of myxoid liposarcoma after a period of remission.


Sickle Cell Trait

description: An individual who is heterozygous for the mutation that causes sickle cell anemia.


Stage II Gastric Cancer AJCC v6

description: Stage II includes: (T1, N2, M0), (T2a/b, N1, M0), (T3, N0, M0).  T1: Tumor invades lamina propria or submucosa. T2: Tumor invades muscularis propria or submucosa.  T2a: Tumor invades muscularis propria.  T2b: Tumor invades subserosa.  T3: Tumor penetrates serosa (visceral peritoneum) without invasion of adjacent structures. N1: Metastasis in 1 to 6 regional lymph nodes. Metastasis in 7 to 15 regional lymph nodes.  M0: No distant metastasis. (AJCC 6th ed.)


Cystic Oncocytic Neoplasm

description: An oncocytoma with cystic degenerative changes.


Sarcoma by FNCLCC Grade

description: Grading of sarcomas according to the French Federation of Cancer Centers Sarcoma Group (FNCLCC). This sarcoma grading system is based on three factors: differentiation, mitotic count, and tumor necrosis. The scores for each factor are added to determine the grade (1 to 3) for the sarcoma.


name: Hodgkin's disease mixed cellularity stage I supradiaphragmatic


Unresectable Gallbladder Carcinoma

description: A carcinoma that arises from the gallbladder and it is not amenable to surgical resection.


Intraoperative Pain

description: Pain occurring during a surgical operation.


Stage IIIA Cutaneous Melanoma AJCC v7

description: Stage IIIA includes: (T1-4a, N1a, M0); (T1-4a, N2a, M0).  T1-4a: Non-ulcerated cutaneous melanoma of any thickness.  N1a: Cutaneous melanoma with micrometastasis in one regional lymph node.  N2a: Cutaneous melanoma with micrometastases in 2-3 regional lymph nodes.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


name: Sustained Ventricular Arrhythmia Related to COVID-19

description: Ventricular tachycardia or ventricular fibrillation lasting greater than or equal to 30 seconds, or requiring direct current cardioversion (DCCV) in a patient with probable or confirmed acute COVID-19.


name: Breast Columnar Cell Hyperplasia with Atypia

description: A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini.  The acini are lined by more than two layers of columnar epithelial cells.  Cytologic atypia is present.  Prominent apical cytoplasmic snouts and intraluminal secretions are also present.


Resectable Liposarcoma

description: Liposarcoma that is amenable to surgical resection.


Stage IIIC Testicular Cancer AJCC v8

description: Stage IIIC includes: (Any pT/TX, N1-3, M0, S3); (Any pT/TX, Any N, M1a, S3); (Any pT/TX, Any N, M1b, Any S). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. M1a: Testicular cancer with non-retroperitoneal nodal or pulmonary metastases. M1b: Testicular cancer with non-pulmonary visceral metastases. S3: LDH more than 10 x N or hCG (mlU/mL) more than 50,000 or AFP (ng/mL) more than 10,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


name: Recurrent Adult Acute Lymphoblastic Leukemia

description: The reemergence of acute lymphoblastic leukemia in adults after a period of remission.


Biliary Intraepithelial Neoplasia-1

description: Biliary intraepithelial neoplasia characterized by the presence of low grade epithelial atypia.


Refractory Aggressive NK-Cell Leukemia

description: Aggressive NK-cell leukemia that is resistant to treatment.


Factor VIII Inactivation

description: Presence of inactivating antibodies to factor VIII in the blood.


Chest Pain in Sternum

description: The location of the chest pain is in the middle of the anterior wall of the thorax, bounded by the clavicles, above, and with the cartilages of the first seven ribs, along the sides.


Scrotal Infection

description: A bacterial, fungal or viral infectious process affecting the scrotum.


Tubular adenoma of breast

description: A benign, well circumscribed neoplasm that arises from the breast.  It is composed entirely of tubular structures that contain epithelial and myoepithelial cells.


Stage IVA Gallbladder Cancer AJCC v7

description: Stage IVA includes: T4, N0-1, M0. T4: Tumor invades the main portal vein or hepatic artery, or invades two or more extrahepatic organs or structures.  N0: No regional lymph node metastasis.  N1: Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein. M0: No distant metastasis.  (from AJCC 7th Ed.)


Ocular surface squamous neoplasia

description: An umbrella term that comprises the spectrum of squamous neoplasms of the conjunctiva, ranging  from low-grade squamous intraepithelial neoplasia to invasive conjunctival squamous cell carcinoma.


Urethritis Cystica and Glandularis

description: A reactive inflammatory disorder affecting the urethra.  It is characterized by the development of small cysts in the urethral wall.  The cysts are lined by urothelial cells and metaplastic glandular cells.


name: Intraocular Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that occurs in the intraocular area.


Chronic Phase Primary Myelofibrosis

description: Primary myelofibrosis characterized by the presence of less than 10% blasts in the peripheral blood or bone marrow.


Advanced NUT Carcinoma

description: NUT carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Immature Granulocytic Sarcoma

description: A granulocytic sarcoma composed of myeloblasts and promyelocytes (WHO 2001).


Staphylococcal osteomyelitis

description: Osteomyelitis resulting from an infection with Staphylococcus.


Non-Neoplastic Lacrimal System Disorder

description: A non-neoplastic disorder that affects the lacrimal gland and/or the lacrimal drainage system.


Unresectable Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that is not amenable to surgical resection.


Childhood Sarcoma

description: A sarcoma that occurs during childhood.


Locally Advanced Anal Carcinoma

description: Anal carcinoma that has spread to nearby tissues or lymph nodes.


name: Mental disorder due to a general medical condition

description: A category of psychiatric disorders which are the direct physiologic consequence of a general medical condition.


Necrotising vasculopathy

description: Disorders of blood vessels characterized by luminal narrowing due to intramural immune deposits.


Liver Dysplastic Nodule

description: A premalignant neoplastic nodular lesion of the liver that usually measures less than 15 mm.  It is found during microscopic examination of liver tissues, usually in cirrhotic livers.  Based on the degree of atypia, it is classified as low or high grade.


name: Pathologic Stage III Retinoblastoma AJCC v8

description: Stage III includes: Any pT, pN1, cM0, Any H. pN1: Regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


name: Metastatic Platinum-Resistant Fallopian Tube Carcinoma

description: A platinum-resistant fallopian tube carcinoma that has spread from its original site of growth to another anatomic site.


Stage I Uterine Corpus Cancer

description: Stage I includes: I (T1, N0, M0); IA: (T1a, N0, M0); IB (T1b, N0, M0). T1: Tumor confined to corpus uteri. T1a: Tumor limited to the endometrium or invades less than one-half of the myometrium. T1b: Tumor invades one-half or more of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Central Nervous System Dermoid Cyst

description: A dermoid cyst arising in the central nervous system.


Traumatic arthropathy

description: Any arthropathy that is caused by trauma.


name: Locally Advanced Pancreatic Adenocarcinoma

description: A pancreatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Advanced Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Systemic Mastocytosis with an Associated Germ Cell Tumor

description: A disorder characterized by systemic infiltration of internal organs by aggregates of neoplastic mast cells and the presence of a co-occurring germ cell tumor.


Abnormal Urine Test Result

description: A laboratory test result indicating a finding outside the parameters of normal urine measurements.


Mesonephric-like adenocarcinoma

description: An exceedingly rare adenocarcinoma that arises from the uterine corpus and ovary and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage.


Adult Acute Megakaryoblastic Leukemia

description: An acute megakaryoblastic leukemia occurring in adults.


Treatment-sensitive HIV Infection

description: An infection with human immunodeficiency virus that responds to therapy.


Acute Myeloid Leukemia with del(20q)

description: Acute myeloid leukemia associated with deletion of the long arm of chromosome 20 [del(20q)].


Ecchordosis physaliphora

description: A very rare, slow growing, usually asymptomatic hamartomatous lesion that arises from ectopic notochordal tissue.  Morphologically it is characterized by the presence of typical physaliphorous cells in a myxoid background.


neoplasm of basal ganglia

description: A benign or malignant neoplasm that affects the basal ganglia.


description: Coagulation disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Cavernous Angioleiomyoma

description: A morphologic variant of angioleiomyoma characterized by the presence of markedly dilated vascular channels.


Peri-prosthetic Joint Infection

description: Infection around an implant following joint replacement.


name: Other Iatrogenic Immunodeficiency-Related Lymphoproliferative Disorders

description: Lymphoid proliferations or lymphomas that arise in patients treated with immunosuppressive drugs for autoimmune diseases or conditions other than in the post-transplant setting. (WHO 2017)


adenocarcinoma of urinary tract

description: A rare carcinoma with pure glandular differentiation arising anywhere in the urinary tract. This group does not include clear cell and endometrioid adenocarcinomas.


name: Metastatic Childhood Ependymoma by Toronto Guidelines v2

description: Disease beyond local site (e.g., other lesions in brain or spine or tumor cells in CSF or distant metastases). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Bacterial gastroenteritis

description: Gastroenteritis resulting from a bacterial infection.


Clinical Course of Disease

description: A term that refers to the nature and/or clinical outcome of a disease (e.g., acute or chronic disease, aggressive or indolent disease, recurrent disease, etc.).


Foregut Neuroendocrine Tumor G3

description: A neuroendocrine tumor grade 3 that arises from the esophagus, stomach, or duodenum.


White Matter Injury

description: Focal areas of necrosis, with or without cysts, and diffuse areas of white matter dysmaturation with maturation arrest of the pre-oligodendroglia cells, located in the cerebral white matter.


Gastric Hodgkin's Lymphoma

description: An extremely rare Hodgkin lymphoma that arises from the stomach.


name: Cervical high grade squamous intraepithelial lesion

description: A precancerous neoplastic process that affects the cervical squamous epithelium. It is usually associated with human papillomavirus infection. It is classified as cervical squamous intraepithelial neoplasia 2 when there is nuclear atypia in both the upper and lower epithelial layers, mitotic figures are confined to the basal two-thirds of the epithelium, and maturation is present in the upper half of the epithelium. It is classified as cervical squamous intraepithelial neoplasia 3 when there is nuclear atypia and mitotic figures throughout the entire thickness of the epithelium, and maturation is absent or confined to the upper third of the epithelium.


name: Pathologic Stage II Esophageal Adenocarcinoma AJCC v8

description: Stage II includes: IIA: (T2, N0, M0, G3); (T2, N0, M0, GX); IIB: (T1, N1, M0, Any G); (T3, N0, M0, Any G). T2: Tumor invades the muscularis propria. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. GX: Grade cannot be assessed. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


description: A meningioma that arises within the cranial cavity and results from exposure to radiation.


Astrocytoma, IDH-Wildtype

description: Astrocytoma lacking mutations in IDH1 or IDH2 genes. It includes diffuse astrocytoma, IDH-wildtype and anaplastic astrocytoma, IDH-wildtype.


name: Stage IA Ampulla of Vater Cancer AJCC v7

description: Stage IA includes: T1, N0, M0. T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Locally Advanced Malignant Skin Neoplasm

description: A malignant neoplasm of the skin that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Unresectable Platinum-Resistant Fallopian Tube Carcinoma

description: A platinum-resistant fallopian tube carcinoma that is not amenable to surgical resection.


name: Unresectable Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted

description: Oligodendroglioma, IDH-mutant and 1p/19q-codeleted that is not amenable to surgical resection.


Myolipoma

description: A benign extrauterine tumor composed of mature adipocytes and smooth muscle cells.


name: Stage IIIA Merkel Cell Carcinoma AJCC v7

description: Stage IIIA includes: Any T, N1a, M0.  N1a: Micrometastasis in regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th Ed.)


Vulvar Tubulovillous Adenoma

description: An intestinal-type adenoma that arises from the vulva. It is characterized by the presence of a tubulovillous architectural pattern.


Benign Thalamic Neoplasm

description: A neoplasm that arises from the thalamus and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Nodular and Massive Retinal Gliosis

description: A spectrum of discrete retinal glial proliferations surrounding blood vessels, ranging in size from small nodules to massive lesions that fill the eye. (WHO 2018)


Conventional Schwannoma

description: A common, usually encapsulated benign nerve sheath tumor composed of well-differentiated Schwann cells.


Borderline Broad Ligament Serous Tumor

description: A rare non-invasive tumor that arises from the broad ligament. It is characterized by the presence of serous epithelial cell proliferation and cytological atypia.


Lymphosarcoma of spleen

description: An antiquated term that refers to a non-Hodgkin lymphoma composed of small and medium sized lymphocytes affecting the spleen.


name: Metastatic Digestive System Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that arises from any part of the digestive system and has metastasized to another anatomic site.


Ache

description: A dull persistent (usually moderately intense) pain.


Thrombotic Disorder

description: A disorder in which there is pathological development of blood clots within the cardiovascular system.


name: Primary cutaneous acral CD8 positive T-cell lymphoma

description: A primary cutaneous T-cell lymphoproliferative disorder that presents as an acral (peripheral) lesion. It is composed of CD8-positive neoplastic T-lymphocytes. It is usually localized to a single site and has an indolent clinical course. Local or more extensive recurrences have been described in a minority of patients.


Secondary Glioblastoma

description: A glioblastoma arising from a lower grade astrocytoma.


description: A lymphoproliferative disorder that occurs in a patient with immunodeficiency.


Recurrent Malignant Glioma

description: The reemergence of malignant glioma after a period of remission.


AIDS-Related Hodgkin Lymphoma

description: Hodgkin lymphoma secondary to AIDS. An increased incidence of Hodgkin lymphomas has been observed in HIV positive patients. Most cases are morphologically classified as lymphocyte depleted or mixed cellularity Hodgkin lymphomas.


name: Solar Radiation-Related Malignant Neoplasm

description: A malignant neoplasm arising in an anatomic site exposed to solar radiation.


Basal cell hyperplasia

description: A pathologic hyperplastic process characterized by the proliferation of the cells of the epithelial layer that resemble the basal cells of the lower part of the epidermis.


Childhood Nervous System Neoplasm

description: A neoplasm that affects the nervous system during childhood.


Extra-adrenal paraganglioma, malignant

description: An extra-adrenal paraganglioma that metastasizes to regional or distant anatomic sites.  Common sites of metastasis include the lymph nodes, lungs, bones, and liver.


Adult Myofibroma

description: A rare myofibroma that occurs in adults.


Subcutaneous edema

description: Presence of edema in subcutaneous connective tissue.


name: Unresectable Abdominal Neuroendocrine Neoplasm

description: An abdominal neuroendocrine neoplasm that is not amenable to surgical resection.


Pelvic Rhabdomyosarcoma

description: Rhabdomyosarcoma involving the organs and structures in the pelvis.


Nodular Melanoma

description: A melanoma that arises from the skin and mucosal sites. It is characterized by a vertical growth phase and lacks a significant radial growth phase. It may or may not arise from a pre-existing nevus. Morphologically, it is characterized by the presence of cohesive aggregates of neoplastic melanocytes in the dermis that often exhibit an epithelioid appearance. The overlying epidermis is often involved.


name: Lugano Classification Stage II Bulky Hodgkin Lymphoma AJCC v8

description: Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


Non-Neoplastic Urethra Disorder

description: A non-neoplastic disorder affecting the urethra.


Recurrent Spindle Cell Sarcoma

description: The reemergence of spindle cell sarcoma after a period of remission.


Unresectable Gallbladder Adenocarcinoma

description: Adenocarcinoma that arises from the gallbladder and is not amenable to surgical resection.


name: Recurrent Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

description: The reemergence of acute myeloid leukemia with recurrent genetic abnormalities after a period of remission.


name: Usual Prostate Adenocarcinoma with Neuroendocrine Differentiation

description: Acinar adenocarcinoma of the prostate gland characterized by the presence of scattered neuroendocrine cells by immunohistochemistry.


Benign neoplasm of broad ligament

description: A neoplasm that arises from the broad ligament and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Mature Plasmacytoid Dendritic Cell Proliferation Associated with Myeloid Neoplasm

description: A clonal proliferation of plasmacytoid dendritic cells in patients with defined myeloid neoplasms. It is characterized by neoplastic proliferations of mature cells with plasmacytoid morphology in the skin, bone marrow, and very rarely, lymph nodes. Patients are predominantly older males.


name: Serous Endometrial Intraepithelial Carcinoma

description: A precursor of endometrial serous adenocarcinoma characterized by the replacement of the normal endometrial cells by malignant glandular cells that resemble the malignant cells of invasive serous adenocarcinoma. The endometrial neoplastic process is non-invasive. It may coexist with invasive endometrial adenocarcinoma or can be associated with metastases outside the uterus, in the absence of invasive endometrial carcinoma.


Arrhythmia-Induced Cardiomyopathy

description: A reversible cardiomyopathy presumed to result from the presence of arrhythmias, including the tachycardia-induced cardiomyopathy (T-CM), atrial fibrillation-induced cardiomyopathy (AF-CM), and premature ventricular contraction-induced cardiomyopathy (PVC-CM).


Stage IIA Prostate Cancer AJCC v7

description: Stage IIA includes: (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X). T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  (AJCC 7th ed.)


Blue rubber bleb nevus syndrome

description: A hemangioma present at birth.  It is characterized by the presence of rubbery skin lesions.


name: Refractory Digestive System Neuroendocrine Neoplasm

description: A digestive system neuroendocrine neoplasm that is resistant to treatment.


Severe Sepsis

description: Clinical syndrome defined by the presence of both infection and a systemic inflammatory response that progresses to multi-organ failure.


Thoracoceloschisis

description: A congenital fissure of both the thoracic and abdominal walls.


In situ mantle cell neoplasia

description: A neoplastic lymphoid process characterized by the presence of cyclin D1 positive lymphoid cells, typically in the inner mantle zones of lymphoid tissue follicles, in cases that do not suggest the diagnosis of a mantle cell lymphoma. It is often found incidentally and has a low rate of progression.


name: Clinical Stage IV Esophageal Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Systemic Hydroa Vacciniforme Lymphoproliferative Disorder

description: Hydroa vacciniforme lymphoproliferative disorder characterized by severe clinical course and associated with fever, lymph node involvement, and involvement of internal organs by EBV-positive T-cells and NK-cells. It usually affects Asian and Latin American individuals.


name: Recurrent Endocervical Adenocarcinoma, Usual-Type

description: The reemergence of endocervical adenocarcinoma, usual-type after a period of remission.


name: Stage III Renal Pelvis and Ureter Cancer AJCC v8

description: Stage III includes: T3, N0, M0. T3: For renal pelvis only: Tumor invades beyond muscularis into peripelvic fat or into the renal parenchyma. For ureter only: Tumor invades beyond muscularis into periureteric fat. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Myeloid Leukemia, Philadelphia- Negative

description: Myeloid leukemia characterized by the absence of Philadelphia chromosome.


Hindgut Neuroendocrine Tumor G1

description: A neuroendocrine tumor that arises from the sigmoid colon, descending colon, or rectum.


Stage IA Osteosarcoma AJCC v7

description: Stage IA includes: T1, N0, M0, G1, G2, GX.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Recurrent Chronic Leukemia

description: The reemergence of chronic leukemia after a period of remission.


Filiform Serrated Adenoma

description: A traditional serrated adenoma characterized by the presence of prominent villous projections of the neoplastic epithelium.


name: Recurrent Acute Panmyelosis with Myelofibrosis

description: The reemergence of acute panmyelosis with myelofibrosis after a period of remission.


Mild epithelial dysplasia

description: A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. It is characterized by the presence of mild epithelial dysplasia.


Neutrophilic dermatosis

description: A type of dermatosis characterized by dense infiltration of neutrophils in the skin without evidence of infection or vasculitis. It may be secondary to an underlying systemic illness.


Non-Neoplastic Cardiovascular Disorder

description: A non-neoplastic disorder that affects the heart and/or vessels.  Representative examples include myocardial infarction, endocarditis, arteriosclerosis, thrombosis, and lymphedema.


name: Locally Advanced Bladder Urothelial Carcinoma

description: A bladder urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


dyskeratosis congenita

description: A rare genetic disorder characterized by nail dystrophy, reticulated skin pigmentation especially on the neck and chest, and oral leukoplakia.  In about half the cases mutations in the TERT, TERC, DKC1, or TINF2 genes are identified.  Patients are at an increased risk of developing bone marrow failure, myelodysplastic syndrome, leukemia, or cancer, especially in the head and neck region.


Chronic acquired lymphedema

description: A condition that is caused by trauma to the lymph system, which disrupts the normal flow of lymph fluid. This is most often due to surgery that requires lymph node removal or a large amount of lymph tissue. This disruption is especially apparent if the lymph nodes under the arm and arm and around the breast are compromised due to breast cancer surgery, diagnostic dissection, mastectomy, or radiation.


name: Chest Pain Along Right Middle Sternal Border

description: The location of the chest pain is along the right middle border of the sternum.


name: Acute Myeloid Leukemia with Myelodysplasia-Related Gene Mutations

description: A group of acute myeloid leukemias characterized by the presence of gene mutations that are associated with myelodysplasia.


Stage IV Prostate Cancer AJCC v6

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, Any N, M1) (Any G).  T4: Tumor is fixed or invades adjacent structures other than seminal vesicles: bladder neck, external sphincter, rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 6th ed.)