name: NCTR1_HUMAN Natural cytotoxicity triggering receptor 1 (sprot)

description: A natural cytotoxicity triggering receptor 1 that is encoded in the genome of human.


iloprost

A carbobicyclic compound that is prostaglandin I2 in which the endocyclic oxygen is replaced by a methylene group and in which the (1E,3S)-3-hydroxyoct-1-en-1-yl side chain is replaced by a (3R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl group. A synthetic analogue of prostacyclin, it is used as the trometamol salt (generally by intravenous infusion) for the treatment of peripheral vascular disease and pulmonary hypertension.


phentolamine

A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.


NORVALINE

A 2-aminopentanoic acid that has S-configuration.


name: KSR1_HUMAN Kinase suppressor of Ras 1 (sprot)

description: A kinase suppressor of Ras 1 that is encoded in the genome of human.


name: CXCL5_HUMAN C-X-C motif chemokine 5 (sprot)

description: A C-X-C motif chemokine 5 that is encoded in the genome of human.


name: CNTP1_HUMAN Contactin-associated protein 1 (sprot)

description: A contactin-associated protein 1 that is encoded in the genome of human.


ITA11_HUMAN Integrin alpha-11 (sprot)

An integrin alpha-11 that is encoded in the genome of human.


name: CPT1B_HUMAN Carnitine O-palmitoyltransferase 1, muscle isoform (sprot)

description: A carnitine O-palmitoyltransferase 1, muscle isoform that is encoded in the genome of human.


name: PXYP1_HUMAN 2-phosphoxylose phosphatase 1 (sprot)

description: A 2-phosphoxylose phosphatase 1 that is encoded in the genome of human.


name: KCNT1_HUMAN Potassium channel subfamily T member 1 (sprot)

description: A potassium channel subfamily T member 1 that is encoded in the genome of human.


name: RSAD2_HUMAN S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (sprot)

description: An S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 that is encoded in the genome of human.


prostate neoplasm

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A neoplasm (disease) that involves the prostate gland.


arteriosclerosis disorder

description: A vascular disorder characterized by thickening and hardening of the walls of the arteries.


BENZENE

A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system.


name: TP4A3_HUMAN Protein tyrosine phosphatase type IVA 3 (sprot)

description: A protein tyrosine phosphatase type IVA 3 that is encoded in the genome of human.


axitinib

An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic treatment.


succimer

A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.


phosphatidylserine (18:0/22:6)

A phosphatidylserine 40:6 in which the acyl group at C-1 contains 18 carbons and no double bonds while that at C-2 contains 22 carbons and 6 double bonds.


name: MYO1A_HUMAN Unconventional myosin-Ia (sprot)

description: A myosin-Ia that is encoded in the genome of human.


carcinoid heart disease

description: Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation.


parkinsonism-dystonia, infantile

description: Infantile dystonia-parkinsonism (IPD) is an extremely rare inherited neurological syndrome that presents in early infancy with hypokinetic parkinsonism and dystonia and that can be fatal.


name: KLF3_HUMAN Krueppel-like factor 3 (sprot)

description: A krueppel-like factor 3 that is encoded in the genome of human.


dutasteride

An aza-steroid that is inasteride in which the tert-butyl group is replaced by a 2,5-bis(trifluoromethyl)phenyl group. A synthetic 4-azasteroid, dutasteride is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5alpha-reductase, an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone. Dutasteride is used for the treatment of symptomatic benign prostatic hyperplasia in men with an enlarged prostate gland.


CLD7_HUMAN Claudin-7 (sprot)

A claudin-7 that is encoded in the genome of human.


name: VGLU2_HUMAN Vesicular glutamate transporter 2 (sprot)

description: A vesicular glutamate transporter 2 that is encoded in the genome of human.


thiopental

A barbiturate, the structure of which is that of 2-thiobarbituric acid substituted at C-5 by ethyl and sec-pentyl groups.


hyperthyroidism

description: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.


name: ABCE1_HUMAN ATP-binding cassette sub-family E member 1 (sprot)

description: An ATP-binding cassette sub-family E member 1 that is encoded in the genome of human.


Aspirin-induced asthma

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A type of asthma in which aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygen-ase 1 (COX-1) exacerbate bronchoconstriction.


SEPP1_HUMAN Selenoprotein P (sprot)

A selenoprotein P that is encoded in the genome of human.


omaveloxolone

A semi-synthetic triterpenoid drug. It is an Nrf2 activator that is approved for the treatment of Friedreich's ataxia in adults and adolescents aged 16 years and older.


TEN3_HUMAN Teneurin-3 (sprot)

A teneurin-3 that is encoded in the genome of human.


name: CAVN1_HUMAN Caveolae-associated protein 1 (sprot)

description: A caveolae-associated protein 1 that is encoded in the genome of human.


KALRN_HUMAN Kalirin (sprot)

A kalirin that is encoded in the genome of human.


name: GET1_HUMAN Guided entry of tail-anchored proteins factor 1 (sprot)

description: A tryptophan-rich protein that is encoded in the genome of human.


name: GBRB3_HUMAN Gamma-aminobutyric acid receptor subunit beta-3 (sprot)

description: A gamma-aminobutyric acid receptor subunit beta-3 that is encoded in the genome of human.


castration-resistant prostate carcinoma

description: A prostate carcinoma that is characterized by continued growth and spread despite the surgical removal of the testes or medical intervention to block androgen production.


resolvin E1

A resolvin that is (6Z,8E,10E,14Z,16E)-icosa-6,8,10,14,16-pentaenoic acid which is substituted at positions 5, 12 and 18 by hydroxy groups (the 5S,12R,18R stereoisomer).


methemoglobinemia

description: An inherited or acquired condition characterized by abnormally increased levels of methemoglobin in the blood.


perphenazine

A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.


name: CCRL2_HUMAN C-C chemokine receptor-like 2 (sprot)

description: A C-C chemokine receptor-like 2 that is encoded in the genome of human.


Jaundice

description: Yellow pigmentation of the skin due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream.


CP2W1_HUMAN Cytochrome P450 2W1 (sprot)

A cytochrome P450 2W1 that is encoded in the genome of human.


lorlatinib

A cyclic ether that is 16,17-dihydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one substituted by methyl groups at positions 2 and 10R, and by cyano, amino and fluoro groups at positions 3, 7 and 12 respectively. It is a small molecule inhibitor of ALK and ROS1 kinase developed by Pfizer for the treatment of ALK-positive non-small cell lung cancer.


estradiol

A 3-hydroxy steroid that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17.


name: KDM7A_HUMAN Lysine-specific demethylase 7A (sprot)

description: A lysine-specific demethylase 7A that is encoded in the genome of human.


name: PNMA1_HUMAN Paraneoplastic antigen Ma1 (sprot)

description: A paraneoplastic antigen Ma1 that is encoded in the genome of human.


streptococcal sore throat

description: Inflammation of the throat due to Streptococcus pyogenes.


name: SIN1_HUMAN Target of rapamycin complex 2 subunit MAPKAP1 (sprot)

description: A target of rapamycin complex 2 subunit MAPKAP1 that is encoded in the genome of human.


TSH2_HUMAN Teashirt homolog 2 (sprot)

A teashirt homolog 2 that is encoded in the genome of human.


bulimia nervosa

description: A disorder characterized by recurrent episodes of binge-eating over which the individual feels a lack of control; these episodes of binge-eating are followed by recurrent compensatory behavior to prevent weight gain, usually self-induced vomiting. In addition, self-evaluation is unduly influenced by body image.


midazolam

An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.


name: KC1A_HUMAN Casein kinase I isoform alpha (sprot)

description: A casein kinase I isoform alpha that is encoded in the genome of human.


name: ATPB_HUMAN ATP synthase subunit beta, mitochondrial (sprot)

description: An ATP synthase subunit beta, mitochondrial that is encoded in the genome of human.


name: ASPH_HUMAN Aspartyl/asparaginyl beta-hydroxylase (sprot)

description: An aspartyl/asparaginyl beta-hydroxylase that is encoded in the genome of human.


herbimycin

A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects.


METHYLTHIOADENOSINE

Adenosine with the hydroxy group at C-5' substituted with a methylthio (methylsulfanyl) group.


mupirocin

An alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections.


AFAD_HUMAN Afadin (sprot)

An afadin that is encoded in the genome of human.


name: CHMP3_HUMAN Charged multivesicular body protein 3 (sprot)

description: A charged multivesicular body protein 3 that is encoded in the genome of human.


name: CHM4A_HUMAN Charged multivesicular body protein 4a (sprot)

description: A charged multivesicular body protein 4a that is encoded in the genome of human.


CADH6_HUMAN Cadherin-6 (sprot)

A cadherin-6 that is encoded in the genome of human.


NEDD8_HUMAN NEDD8 (sprot)

A NEDD8 protein that is encoded in the genome of human.


necrotizing vasculitis

description: A type of vasculitis that is comprised of vasculitides that present with necrosis.


phosphatidylinositol (16:0/18:3)

A phosphatidylinositol 34:3 in which the acyl group at C-1 contains 16 carbons and no double bonds while that at C-2 contains 18 carbons and 3 double bonds


name: TRH_HUMAN Pro-thyrotropin-releasing hormone (sprot)

description: A pro-thyrotropin-releasing hormone that is encoded in the genome of human.


name: CLK2_HUMAN Dual specificity protein kinase CLK2 (sprot)

description: A dual specificity protein kinase CLK2 that is encoded in the genome of human.


name: VGLU3_HUMAN Vesicular glutamate transporter 3 (sprot)

description: A vesicular glutamate transporter 3 that is encoded in the genome of human.


Anhedonia

description: Inability to experience pleasurable activities usually found enjoyable.


Postprandial hyperglycemia

description: An increased concentration of glucose in the blood following a meal.


name: TRML4_HUMAN Trem-like transcript 4 protein (sprot)

description: A trem-like transcript 4 protein that is encoded in the genome of human.


name: KCND2_HUMAN Potassium voltage-gated channel subfamily D member 2 (sprot)

description: A voltage-gated potassium channel KCND2 that is encoded in the genome of human.


name: KPCI_HUMAN Protein kinase C iota type (sprot)

description: A protein kinase C iota type that is encoded in the genome of human.


name: MADCA_HUMAN Mucosal addressin cell adhesion molecule 1 (sprot)

description: A mucosal addressin cell adhesion molecule 1 that is encoded in the genome of human.


Exudative retinal detachment

description: A type of retinal detachment arising from damage to the outer blood-retinal barrier that allows fluid to access the subretinal space and separate the neurosensory retina from the retinal pigment epithelium.


entinostat

A member of the class of benzamides resulting from the formal condensation of the carboxy group of the pyridin-3-ylmethyl carbamate derivative of p-(aminomethyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an inhibitor of histone deacetylase isoform 1 (HDAC1) and isoform 3 (HDAC3).


LIPL_HUMAN Lipoprotein lipase (sprot)

A lipoprotein lipase that is encoded in the genome of human.


APOA4_HUMAN Apolipoprotein A-IV (sprot)

An apolipoprotein A-IV that is encoded in the genome of human.


name: PR38B_HUMAN Pre-mRNA-splicing factor 38B (sprot)

description: A pre-mRNA-splicing factor 38B that is encoded in the genome of human.


name: polyarticular juvenile rheumatoid arthritis


twin to twin transfusion syndrome

description: Twin twin transfusion syndrome (TTTS) is a rare condition seen in twin monochorionic pregnancies, typically developing during the 15-26 week gestation period and usually due to unbalanced intertwin placental anastomoses, where an unequal exchange of blood between twins causes oligohydramnios in one sac and polyhydramnios in the other which can lead to a high perinatal mortality rate and a high rate of disability in survivors if left untreated


An aromatic ether that is phenoxyacetic acid in which the phenyl group is substituted at position 2 by a methyl group and at position 4 by a (1,3-thiazol-5-ylmethyl)sulfanediyl group, and in which the 1,3-thiazolyl group is substituted at positions 2 and 4 by p-trifluoromethylphenyl and methyl groups, respectively.


NPHN_HUMAN Nephrin (sprot)

A nephrin that is encoded in the genome of human.


name: ARI5B_HUMAN AT-rich interactive domain-containing protein 5B (sprot)

description: An AT-rich interactive domain-containing protein 5B that is encoded in the genome of human.


name: ARL4A_HUMAN ADP-ribosylation factor-like protein 4A (sprot)

description: An ADP-ribosylation factor-like protein 4A that is encoded in the genome of human.


phosphoramidon

A dipeptide isolated from the cultures of Streptomyces tanashiensis.


A triamino-1,3,5-triazine that is 1,3,5-triazine in which two of the hydrogens have been replaced by morpholin-4-yl groups while the third hydrogen has been replaced by a 2-(difluoromethyl)benzimidazol-1-yl group. It is an inhibitor of phosphatidylinositol 3-kinase.


name: EPAS1_HUMAN Endothelial PAS domain-containing protein 1 (sprot)

description: An endothelial PAS domain-containing protein 1 that is encoded in the genome of human.


name: MDR1_HUMAN ATP-dependent translocase ABCB1 (sprot)

description: An ATP-dependent translocase ABCB1 that is encoded in the genome of human.


name: IGSF8_HUMAN Immunoglobulin superfamily member 8 (sprot)

description: An immunoglobulin superfamily member 8 that is encoded in the genome of human.


name: FKB15_HUMAN FK506-binding protein 15 (sprot)

description: An FK506-binding protein 15 that is encoded in the genome of human.


name: SC24B_HUMAN Protein transport protein Sec24B (sprot)

description: A protein transport protein Sec24B that is encoded in the genome of human.


name: RHG09_HUMAN Rho GTPase-activating protein 9 (sprot)

description: A Rho GTPase-activating protein 9 that is encoded in the genome of human.


Acute sinusitis

description: An acute form of sinusitis.


PODN_HUMAN Podocan (sprot)

A podocan that is encoded in the genome of human.


DYSF_HUMAN Dysferlin (sprot)

A dysferlin that is encoded in the genome of human.


KALM_HUMAN Anosmin-1 (sprot)

An anosmin-1 that is encoded in the genome of human.


name: SLAF6_HUMAN SLAM family member 6 (sprot)

description: A SLAM family member 6 that is encoded in the genome of human.


NAD

Abbreviation for nicotinamide-adenine dinucleotide when its oxidation state is unknown or unspecified. It is used in metabolic pathways like glycolysis and citric acid cycle.


name: ABLM1_HUMAN Actin-binding LIM protein 1 (sprot)

description: An actin-binding LIM protein 1 that is encoded in the genome of human.


name: DNJC2_HUMAN DnaJ homolog subfamily C member 2 (sprot)

description: A DnaJ homolog subfamily C member 2 that is encoded in the genome of human.


γ-hydroxybutyrate

A 4-hydroxy monocarboxylic acid that is butyric acid in which one of the hydrogens at position 4 is replaced by a hydroxy group.


alexithymia

description: An agnosia that is a deficiency in understanding, processing, or describing emotions.


name: SIAH2_HUMAN E3 ubiquitin-protein ligase SIAH2 (sprot)

description: An E3 ubiquitin-protein ligase SIAH2 that is encoded in the genome of human.


name: ILRL1_HUMAN Interleukin-1 receptor-like 1 (sprot)

description: An interleukin-1 receptor-like 1 that is encoded in the genome of human.


name: NEGR1_HUMAN Neuronal growth regulator 1 (sprot)

description: A neuronal growth regulator 1 that is encoded in the genome of human.


TENS3_HUMAN Tensin-3 (sprot)

A tensin-3 that is encoded in the genome of human.


name: GLSL_HUMAN Glutaminase liver isoform, mitochondrial (sprot)

description: A glutaminase liver isoform, mitochondrial that is encoded in the genome of human.


name: AATM_HUMAN Aspartate aminotransferase, mitochondrial (sprot)

description: An aspartate aminotransferase, mitochondrial that is encoded in the genome of human.


name: MGAT1_HUMAN Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (sprot)

description: An alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase that is encoded in the genome of human.


cinnamaldehyde

The E (trans) stereoisomer of cinnamaldehyde, the parent of the class of cinnamaldehydes.


neuritis

description: A neuropathy arising from inflammation of one or more nerves.


name: CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B (sprot)

description: An E3 ubiquitin-protein ligase CBL-B that is encoded in the genome of human.


phosphatidylethanolamine (18:2/20:4)

A phosphatidylethanolamine 38:6 in which the acyl group at C-1 contains 18 carbons and 2 double bonds while that at C-2 contains 20 carbons and 4 double bonds.


name: DYH8_HUMAN Dynein axonemal heavy chain 8 (sprot)

description: A dynein axonemal heavy chain 8 that is encoded in the genome of human.


cystoid macular edema

description: An autosomal dominantly inherited cystoid macular edema manifesting with macular atrophy, strabismus and, sometimes, pericentral retinitis pigmentosa. It is associated with a poor visual prognosis.


name: WIPI1_HUMAN WD repeat domain phosphoinositide-interacting protein 1 (sprot)

description: A WD repeat domain phosphoinositide-interacting protein 1 that is encoded in the genome of human.


name: ATG9A_HUMAN Autophagy-related protein 9A (sprot)

description: An autophagy-related protein 9A that is encoded in the genome of human.


name: CIB2_HUMAN Calcium and integrin-binding family member 2 (sprot)

description: A calcium and integrin-binding family member 2 that is encoded in the genome of human.


name: S4A7_HUMAN Sodium bicarbonate cotransporter 3 (sprot)

description: A sodium bicarbonate cotransporter 3 that is encoded in the genome of human.


name: TADA1_HUMAN Transcriptional adapter 1 (sprot)

description: A transcriptional adapter 1-like protein that is encoded in the genome of human.


name: F10A1_HUMAN Hsc70-interacting protein (sprot)

description: An Hsc70-interacting protein that is encoded in the genome of human.


diacylglycerol (16:0/22:6/0:0)

A 1,2-diglyceride in which the fatty acyl groups at positions 1 and 2 are specified as C16:0 and C22:6 respectively.


Myocardial fibrosis

description: Myocardial fibrosis is characterized by dysregulated collagen turnover (increased synthesis predominates over unchanged or decreased degradation) and excessive diffuse collagen accumulation in the interstitial and perivascular spaces as well as by phenotypically transformed fibroblasts, termed myofibroblasts.


SEM3A_HUMAN Semaphorin-3A (sprot)

A semaphorin-3A that is encoded in the genome of human.


acute basophilic leukemia

description: A rare acute myeloid leukemia in which the immature cells differentiate towards basophils.


STRN_HUMAN Striatin (sprot)

A striatin that is encoded in the genome of human.


name: SAV1_HUMAN Protein salvador homolog 1 (sprot)

description: A protein salvador homolog 1 that is encoded in the genome of human.


An N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2.


name: WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP2 (sprot)

description: A NEDD4-like E3 ubiquitin-protein ligase WWP2 that is encoded in the genome of human.


name: combined oxidative phosphorylation deficiency

description: A mitochondrial oxidative phosphorylation disorder in which multiple mitochondrial respiratory chain complexes.


name: ZBT16_HUMAN Zinc finger and BTB domain-containing protein 16 (sprot)

description: A zinc finger and BTB domain-containing protein 16 that is encoded in the genome of human.


JPH3_HUMAN Junctophilin-3 (sprot)

A junctophilin-3 that is encoded in the genome of human.


canine sarcoma

description: A malignant mesenchymal neoplasm that affects dogs. It arises from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels.


TFF1_HUMAN Trefoil factor 1 (sprot)

A trefoil factor 1 that is encoded in the genome of human.


TRICIRIBINE

A nucleoside analogue in which the nucleobase portion is a 1,4,5,6,8-pentaazaacenaphthylene ring system substituted with an amino group at position 3, and a methyl group at position 5 and is bound to the beta-D-ribofuranosyl moiety by an N(1)-glycosidic linkage.


respiratory tract infectious disorder

description: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.


chronic otitis media

description: Chronic form of otitis media (disease).


name: MIRO2_HUMAN Mitochondrial Rho GTPase 2 (sprot)

description: A mitochondrial Rho GTPase 2 that is encoded in the genome of human.


name: PTX3_HUMAN Pentraxin-related protein PTX3 (sprot)

description: A pentraxin-related protein PTX3 that is encoded in the genome of human.


ANILINE

A primary arylamine in which an amino functional group is substituted for one of the benzene hydrogens.


DERL1_HUMAN Derlin-1 (sprot)

A derlin-1 that is encoded in the genome of human.


name: PPB1_HUMAN Alkaline phosphatase, placental type (sprot)

description: An alkaline phosphatase, placental type that is encoded in the genome of human.


ciclopirox

A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and cyclohexyl groups, respectively. A broad spectrum antigfungal agent, it also exhibits antibacterial activity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin and nail infections.


name: FLI1_HUMAN Friend leukemia integration 1 transcription factor (sprot)

description: A Friend leukemia integration 1 transcription factor that is encoded in the genome of human.


BI1_HUMAN Bax inhibitor 1 (sprot)

A Bax inhibitor 1 that is encoded in the genome of human.


PLIN1_HUMAN Perilipin-1 (sprot)

A perilipin-1 that is encoded in the genome of human.


rigosertib

An N-[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine in which the double bond has E-configuration. It is a non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM and exhibits anti-cancer properties.


Peripheral edema

description: An abnormal accumulation of interstitial fluid in the soft tissues of the limbs.


nephrosis

description: Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.


name: PE2R4_HUMAN Prostaglandin E2 receptor EP4 subtype (sprot)

description: A prostaglandin E2 receptor EP4 subtype that is encoded in the genome of human.


name: BRD3_HUMAN Bromodomain-containing protein 3 (sprot)

description: A bromodomain-containing protein 3 that is encoded in the genome of human.


adrenal cortex carcinoma

description: A rare, usually large (greater than 5cm), malignant epithelial tumor arising from the adrenal cortical cells. Symptoms are usually related to the excessive production of hormones, and include Cushing's syndrome and virilism in women. Common sites of metastasis include liver, lung, bone, and retroperitoneal lymph nodes. Advanced radiologic procedures have enabled the detection of small tumors, resulting in the improvement of the 5-year survival.


name: RT29_HUMAN Small ribosomal subunit protein mS29 (sprot)

description: A small ribosomal subunit protein mS29 that is encoded in the genome of human.


A member of the class of imidazopyridines that is imidazo[1,5-a]pyridine substituted by (2-fluoro-4-iodophenyl)amino and (2-hydroxyethoxy)aminoacyl groups at positions 5 and 6. It is a potent ATP non-competitive inhibitor of MEK1 (Ki = 0.13nM) and also has efficacy against both mutant BRAF and mutant KRAS. It is in clinical development for treatment of patients with locally advanced or metastatic solid tumors.


infectious colitis

description: A viral or bacterial infectious process affecting the large intestine.


name: ALK_HUMAN ALK tyrosine kinase receptor (sprot)

description: An ALK tyrosine kinase receptor that is encoded in the genome of human.


clocortolone

16alpha-Methylpregna-1,4-diene-3,20-dione bearing hydroxy substituents at the 11beta and 21 positions, fluorine at position 6 and chlorine at position 9. A medium potency corticosteroid, it is used as its 21-O-pivalate or caproate ester for the relief of inflammatory and pruritic (itching) skin disorders.


name: LPAL2_HUMAN Putative apolipoprotein(a)-like protein 2 (sprot)

description: A putative apolipoprotein(a)-like protein 2 that is encoded in the genome of human.


name: XCT_HUMAN Cystine/glutamate transporter (sprot)

description: A cystine/glutamate transporter that is encoded in the genome of human.


name: ACKR3_HUMAN Atypical chemokine receptor 3 (sprot)

description: An atypical chemokine receptor 3 that is encoded in the genome of human.


CORT_HUMAN Cortistatin (sprot)

A cortistatin that is encoded in the genome of human.


name: PRDM4_HUMAN PR domain zinc finger protein 4 (sprot)

description: A PR domain zinc finger protein 4 that is encoded in the genome of human.


lymphedema

description: Excess fluid collection in tissues, causing swelling. It is the result of obstruction of lymphatic vessels or lymph nodes.


podophyllotoxin

An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent. It is found in the roots and rhizomes of Podophyllum species and is used for the topical treatment of genital warts.


CP19A_HUMAN Aromatase (sprot)

An aromatase that is encoded in the genome of human.


MYH11_HUMAN Myosin-11 (sprot)

A myosin-11 that is encoded in the genome of human.


name: IL1R1_HUMAN Interleukin-1 receptor type 1 (sprot)

description: An interleukin-1 receptor type 1 that is encoded in the genome of human.


name: CKLF5_HUMAN CKLF-like MARVEL transmembrane domain-containing protein 5 (sprot)

description: A CKLF-like MARVEL transmembrane domain-containing protein 5 that is encoded in the genome of human.


name: AIM2_HUMAN Interferon-inducible protein AIM2 (sprot)

description: An interferon-inducible protein AIM2 that is encoded in the genome of human.


CCN2_HUMAN CCN family member 2 (sprot)

A CCN family member 2 that is encoded in the genome of human.


name: AGRG2_HUMAN Adhesion G-protein coupled receptor G2 (sprot)

description: An adhesion G-protein coupled receptor G2 that is encoded in the genome of human.


CTNS_HUMAN Cystinosin (sprot)

A cystinosin that is encoded in the genome of human.


name: CO2A1_HUMAN Collagen alpha-1(II) chain (sprot)

description: A collagen type II alpha chain that is encoded in the genome of human.


deoxycholic acid

A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.


hepatoid adenocarcinoma

description: An adenocarcinoma with morphologic characteristics similar to hepatocellular carcinoma, arising from an anatomic site other than the liver.


name: CARD9_HUMAN Caspase recruitment domain-containing protein 9 (sprot)

description: A caspase recruitment domain-containing protein 9 that is encoded in the genome of human.


Cushing syndrome

description: Cushing's syndrome (CS) encompasses a group of hormonal disorders caused by prolonged and high exposure levels to glucocorticoids that can be of either endogenous (adrenal cortex production) or exogenous (iatrogenic) origin.


name: GRWD1_HUMAN Glutamate-rich WD repeat-containing protein 1 (sprot)

description: A glutamate-rich WD repeat-containing protein 1 that is encoded in the genome of human.


name: FTMT_HUMAN Ferritin, mitochondrial (sprot)

description: A ferritin, mitochondrial that is encoded in the genome of human.


name: RNH2B_HUMAN Ribonuclease H2 subunit B (sprot)

description: A ribonuclease H2 subunit B that is encoded in the genome of human.


name: DYLT1_HUMAN Dynein light chain Tctex-type 1 (sprot)

description: A dynein light chain Tctex-type 1 that is encoded in the genome of human.


name: NPVF_HUMAN Pro-FMRFamide-related neuropeptide VF (sprot)

description: An FMRFamide-related neuropeptide VF that is encoded in the genome of human.


Epileptic encephalopathy

description: A condition in which epileptiform abnormalities are believed to contribute to the progressive disturbance in cerebral function. Epileptic encephalaopathy is characterized by (1) electrographic EEG paroxysmal activity that is often aggressive, (2) seizures that are usually multiform and intractable, (3) cognitive, behavioral and neurological deficits that may be relentless, and (4) sometimes early death.


tadalafil

A pyrazinopyridoindole that is 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione substituted at position 2 by a methyl group and at position 6 by a 1,3-benzodioxol-5-yl group (the 6R,12aR-diastereomer). A phosphodiesterase V inhibitor inhibitor, currently marketed in pill form for treating erectile dysfunction under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.


ceruletide

A decapeptide comprising 5-oxoprolyl, glutamyl, aspartyl, O-sulfotyrosyl, threonyl, glycyl, tryptopyl, methionyl, aspartyl and phenylalaninamide residues in sequence. Found in the skins of certain Australian amphibians, it is an analogue of the gastrointestinal peptide hormone cholecystokinin and stimulates gastric, biliary, and pancreatic secretion. It is used in cases of paralysis of the intestine (paralytic ileus) and as a diagnostic aid in pancreatic malfunction.


name: CXL11_HUMAN C-X-C motif chemokine 11 (sprot)

description: A C-X-C motif chemokine 11 that is encoded in the genome of human.


RCN1_HUMAN Reticulocalbin-1 (sprot)

A reticulocalbin-1 that is encoded in the genome of human.


CASP7_HUMAN Caspase-7 (sprot)

A caspase-7 that is encoded in the genome of human.


suvorexant

An aromatic amide obtained by formal condensation of the carboxy group of 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid with the secondary amino group of 5-chloro-2-[(5R)-5-methyl-1,4-diazepan-1-yl]-1,3-benzoxazole. An orexin receptor antagonist used for the management of insomnia.


name: STRA8_HUMAN Stimulated by retinoic acid gene 8 protein homolog (sprot)

description: A stimulated by retinoic acid gene 8 protein that is encoded in the genome of human.


name: CP26B_HUMAN Cytochrome P450 26B1 (sprot)

description: A cytochrome P450 26B1 that is encoded in the genome of human.


name: CNR1_HUMAN Cannabinoid receptor 1 (sprot)

description: A cannabinoid receptor 1 that is encoded in the genome of human.


name: ZN664_HUMAN Zinc finger protein 664 (sprot)

description: A zinc finger protein 664 that is encoded in the genome of human.


CYC_HUMAN Cytochrome c (sprot)

A cytochrome c, somatic that is encoded in the genome of human.


dimyristoylphosphatidylcholine

A phosphatidylcholine where the phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).


name: HBG2_HUMAN Hemoglobin subunit gamma-2 (sprot)

description: A hemoglobin subunit gamma-2 that is encoded in the genome of human.


name: ARAF_HUMAN Serine/threonine-protein kinase A-Raf (sprot)

description: A serine/threonine-protein kinase A-Raf that is encoded in the genome of human.


DPEP2_HUMAN Dipeptidase 2 (sprot)

A dipeptidase 2 that is encoded in the genome of human.


name: PAK6_HUMAN Serine/threonine-protein kinase PAK 6 (sprot)

description: A serine/threonine-protein kinase PAK 6 that is encoded in the genome of human.


trigeminal neuralgia

description: Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theface), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.


neuralgia

description: A pain disorder characterize by pain in the distribution of a nerve or nerves


name: KIF23_HUMAN Kinesin-like protein KIF23 (sprot)

description: A kinesin-like protein KIF23 that is encoded in the genome of human.


name: KCC4_HUMAN Calcium/calmodulin-dependent protein kinase type IV (sprot)

description: A calcium/calmodulin-dependent protein kinase type IV that is encoded in the genome of human.


Compensated hypothyroidism

description: Condition associated with a raised serum concentration of thyroid stimulating hormone (TSH) but a normal serum free thyroxine (FT4).


name: XRCC3_HUMAN DNA repair protein XRCC3 (sprot)

description: A DNA repair protein XRCC3 that is encoded in the genome of human.


pexidartinib

A pyrrolopyridine that is 5-chloro-1H-pyrrolo[2,3-b]pyridine which is substituted by a [6-({[6-(trifluoromethyl)pyridin-3-yl]methyl}amino)pyridin-3-yl]methyl group at position 3. It is a potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, KIT, and FLT3 (IC50 of 20 nM, 10 nM and 160 nM, respectively). Approved by the FDA for the treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT).


mucosal melanoma

description: A melanoma that arises from a mucosal site.


ursodeoxycholic acid

A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.


TOYOCAMYCIN

An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group.


name: MANEA_HUMAN Glycoprotein endo-alpha-1,2-mannosidase (sprot)

description: A glycoprotein endo-alpha-1,2-mannosidase that is encoded in the genome of human.


A member of the class of pyrazines that is amiloride in which the two amino hydrogens at position N-5 are replaced by a hexamethylene moiety, resulting in the formation of an azepane ring.


name: SL9A1_HUMAN Sodium/hydrogen exchanger 1 (sprot)

description: A sodium/hydrogen exchanger 1 that is encoded in the genome of human.


CRY2_HUMAN Cryptochrome-2 (sprot)

A cryptochrome-2 that is encoded in the genome of human.


RASN_HUMAN GTPase NRas (sprot)

A GTPase NRas that is encoded in the genome of human.


name: RREB1_HUMAN Ras-responsive element-binding protein 1 (sprot)

description: A Ras-responsive element-binding protein 1 that is encoded in the genome of human.


MMRN2_HUMAN Multimerin-2 (sprot)

A multimerin-2 that is encoded in the genome of human.


ramipril

A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.


name: PHX2A_HUMAN Paired mesoderm homeobox protein 2A (sprot)

description: A paired mesoderm homeobox protein 2A that is encoded in the genome of human.


DREB_HUMAN Drebrin (sprot)

A drebrin that is encoded in the genome of human.


name: A16L1_HUMAN Autophagy-related protein 16-1 (sprot)

description: An autophagy-related protein 16-1 that is encoded in the genome of human.


sufentanil

An anilide resulting from the formal condensation of the aryl amino group of 4-(methoxymethyl)-N-phenyl-1-[2-(2-thienyl)ethyl]piperidin-4-amine with propanoic acid.


colesevelam

A polyallylamine cross-linked with epichlorohydrin and alkylated with 1-bromodecane and 6-bromohexyltrimethylammonium bromide. It is used as its hydrochloride as an orally administered bile acid sequestrant to reduce the amount of cholesterol and certain fatty substances in the blood.


name: PGTB1_HUMAN Geranylgeranyl transferase type-1 subunit beta (sprot)

description: A geranylgeranyl transferase type-1 subunit beta that is encoded in the genome of human.


doxifluridine

A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an  oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluorouracil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.


allergic rhinitis

description: Inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea, and itching. It may lead to fatigue, drowsiness, and malaise thus causing impairment of the quality of life.


name: MOAP1_HUMAN Modulator of apoptosis 1 (sprot)

description: A modulator of apoptosis 1 that is encoded in the genome of human.


GPC1_HUMAN Glypican-1 (sprot)

A glypican-1 that is encoded in the genome of human.


name: RHG17_HUMAN Rho GTPase-activating protein 17 (sprot)

description: A Rho GTPase-activating protein 17 that is encoded in the genome of human.


halothane

A haloalkane comprising ethane having three flouro substituents at the 1-position as well as bromo- and chloro substituents at the 2-position.


name: NKX31_HUMAN Homeobox protein Nkx-3.1 (sprot)

description: A homeobox protein Nkx-3.1 that is encoded in the genome of human.


name: PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (sprot)

description: A serine/threonine-protein phosphatase PP1-alpha catalytic subunit that is encoded in the genome of human.


name: S19A1_HUMAN Reduced folate transporter (sprot)

description: A reduced folate transporter that is encoded in the genome of human.


thromboangiitis obliterans

description: A rare inflammatory non-necrotizing vascular disease affecting the small- and medium-sized arteries and veins of the upper and lower extremities characterized by endarteritis and vaso-occlusion due to occlusive thrombus development. The development and progression of the disease is consistently associated with exposure to tobacco.


name: IFIT5_HUMAN Interferon-induced protein with tetratricopeptide repeats 5 (sprot)

description: An interferon-induced protein with tetratricopeptide repeats 5 that is encoded in the genome of human.


SON_HUMAN Protein SON (sprot)

A SON protein that is encoded in the genome of human.


name: ENY2_HUMAN Transcription and mRNA export factor ENY2 (sprot)

description: A transcription and mRNA export factor ENY2 that is encoded in the genome of human.


spindle cell neoplasm

description: A benign or malignant neoplasm characterized by the presence of neoplastic spindle cells.


name: KHDR3_HUMAN KH domain-containing, RNA-binding, signal transduction-associated protein 3 (sprot)

description: A KH domain-containing, RNA-binding, signal transduction-associated protein 3 that is encoded in the genome of human.


name: NBEL2_HUMAN Neurobeachin-like protein 2 (sprot)

description: A neurobeachin-like protein 2 that is encoded in the genome of human.


NBEA_HUMAN Neurobeachin (sprot)

A neurobeachin that is encoded in the genome of human.


name: ABCD1_HUMAN ATP-binding cassette sub-family D member 1 (sprot)

description: An ATP-binding cassette sub-family D member 1 that is encoded in the genome of human.


name: TADA3_HUMAN Transcriptional adapter 3 (sprot)

description: A transcriptional adapter 3 that is encoded in the genome of human.


zolpidem

An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.


mebendazole

A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.


bronchogenic carcinoma

description: A lung carcinoma arising from the bronchial epithelium.


name: MYL9_HUMAN Myosin regulatory light polypeptide 9 (sprot)

description: A myosin regulatory light polypeptide 9 that is encoded in the genome of human.


name: ELF3_HUMAN ETS-related transcription factor Elf-3 (sprot)

description: An ETS-related transcription factor Elf-3 that is encoded in the genome of human.


name: COPD_HUMAN Coatomer subunit delta (sprot)

description: A coatomer subunit delta that is encoded in the genome of human.


phosphatidylcholine (O-16:1/18:2)

A 2-acyl-1-alkyl-sn-glycero-3-phosphocholine in which the acyl group contains 18 carbons and 2 double bonds while the alkyl group contains 16 carbons and 1 double bond.


short bowel syndrome

description: Short bowel syndrome is an intestinal failure due to either a congenital defect, intestinal infarction or extensive surgical resection of the intestinal tract that results in a functional small intestine of less than 200cm in length and is characterized by diarrhea, nutrient malabsoption, bowel dilation and dysmobility.


name: KCNC3_HUMAN Potassium voltage-gated channel subfamily C member 3 (sprot)

description: A voltage-gated potassium channel KCNC3 that is encoded in the genome of human.


name: PAX2_HUMAN Paired box protein Pax-2 (sprot)

description: A paired box protein Pax-2 that is encoded in the genome of human.


roflumilast

A benzamide obtained by formal condensation of the carboxy group of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid with the amino group of 3,5-dichloropyridin-4-amine. Used for treatment of bronchial asthma and chronic obstructive pulmonary disease.


name: DNAI2_HUMAN Dynein axonemal intermediate chain 2 (sprot)

description: A dynein axonemal intermediate chain 2 that is encoded in the genome of human.


dehydroepiandrosterone sulphate

A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone.


description: Metabolic dysfunction-associated steatohepatitis (MASH, formerly known as nonalcoholic steatohepatitis or NASH) is a type of fatty liver disease. It often develops due to a metabolic disorder, such as obesity or diabetes, resulting in a toxic buildup of fat in the liver. It is the most severe form of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as nonalcoholic fatty liver disease or NAFLD).


name: CNDD3_HUMAN Condensin-2 complex subunit D3 (sprot)

description: A condensin-2 complex subunit D3 that is encoded in the genome of human.


WNT3A_HUMAN Protein Wnt-3a (sprot)

A protein Wnt-3a that is encoded in the genome of human.


intestinal obstruction

description: Blockage of the normal flow of the intestinal contents within the bowel.


name: HXA9_HUMAN Homeobox protein Hox-A9 (sprot)

description: A homeobox protein Hox-A9 that is encoded in the genome of human.


MTX2_HUMAN Metaxin-2 (sprot)

A metaxin-2 that is encoded in the genome of human.


name: TNR25_HUMAN Tumor necrosis factor receptor superfamily member 25 (sprot)

description: A tumor necrosis factor receptor superfamily member 25 that is encoded in the genome of human.


name: TTF1_HUMAN Transcription termination factor 1 (sprot)

description: A transcription termination factor 1 that is encoded in the genome of human.


FLUORESCEIN

A xanthene dye that is highly fluorescent and commonly used as a fluorescent tracer.


name: S38A3_HUMAN Sodium-coupled neutral amino acid transporter 3 (sprot)

description: A sodium-coupled neutral amino acid transporter 3 that is encoded in the genome of human.


name: HACD3_HUMAN Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (sprot)

description: A very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 that is encoded in the genome of human.


clozapine

A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like  schizophrenia.


A quinoline N-oxide carrying a nitro substituent at position 4.


name: HPCL1_HUMAN Hippocalcin-like protein 1 (sprot)

description: A hippocalcin-like protein 1 that is encoded in the genome of human.


gynecomastia disorder

description: Development of breast tissue in males.


levamisole

A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.


eprosartan

A member of the class of  imidazoles and  thiophenes  that is an angiotensin II receptor antagonist used for the treatment of high blood pressure.


name: ADH7_HUMAN All-trans-retinol dehydrogenase [NAD(+)] ADH7 (sprot)

description: An all-trans-retinol dehydrogenase [NAD(+)] ADH7 that is encoded in the genome of human.


GPC6_HUMAN Glypican-6 (sprot)

A glypican-6 that is encoded in the genome of human.


name: GDPD5_HUMAN Glycerophosphodiester phosphodiesterase domain-containing protein 5 (sprot)

description: A glycerophosphodiester phosphodiesterase domain-containing protein 5 that is encoded in the genome of human.


EFNA5_HUMAN Ephrin-A5 (sprot)

An ephrin-A5 that is encoded in the genome of human.


PRAMIPEXOLE DIHYDROCHLORIDE

A hydrate that is the monohydrate of the dihydrochloride salt of pramiprexole.


benzbromarone

1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication.


CFAH_HUMAN Complement factor H (sprot)

A complement factor H that is encoded in the genome of human.


name: TET3_HUMAN Methylcytosine dioxygenase TET3 (sprot)

description: A methylcytosine dioxygenase TET3 that is encoded in the genome of human.


TRIFLUOROMETHANESULFONIC ACID

A one-carbon compound that is methanesulfonic acid in which the hydrogens attached to the methyl carbon have been replaced by fluorines.


SALL1_HUMAN Sal-like protein 1 (sprot)

A Sal-like protein 1 that is encoded in the genome of human.


name: PLK2_HUMAN Serine/threonine-protein kinase PLK2 (sprot)

description: A serine/threonine-protein kinase PLK2 that is encoded in the genome of human.


name: MYPT1_HUMAN Protein phosphatase 1 regulatory subunit 12A (sprot)

description: A protein phosphatase 1 regulatory subunit 12A that is encoded in the genome of human.


budesonide

A glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis.


kidney cancer

description: Primary or metastatic malignant neoplasm involving the kidney.


name: CAF1B_HUMAN Chromatin assembly factor 1 subunit B (sprot)

description: A chromatin assembly factor 1 subunit B that is encoded in the genome of human.


name: PDE1B_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (sprot)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B that is encoded in the genome of human.


Gilbert syndrome

description: An autosomal recessive inherited disorder characterized by unconjugated hyperbilirubinemia, resulting in harmless intermittent jaundice.


name: punctate palmoplantar keratoderma type 2

description: Punctate palmoplantar keratoderma type 2 is a type of isolated, punctate, hereditary palmoplantar keratoderma characterized by multiple, asymptomatic, 1 to 2 mm-long, firm, hyperkeratotic projections ("spiny keratosis") on the palms, soles and digits (typically confined to their volar and/or lateral aspects). Histopathologically, compact columnar parakeratosis over hypo- or agranular epidermis is observed.


name: TAF7L_HUMAN Transcription initiation factor TFIID subunit 7-like (sprot)

description: A transcription initiation factor TFIID subunit 7-like that is encoded in the genome of human.


name: TLE3_HUMAN Transducin-like enhancer protein 3 (sprot)

description: A transducin-like enhancer protein 3 that is encoded in the genome of human.


name: DOC10_HUMAN Dedicator of cytokinesis protein 10 (sprot)

description: A dedicator of cytokinesis protein 10 that is encoded in the genome of human.


chordoma

description: Chordomas are rare malignant tumors arising from embryonic remnants of the notochord in axial skeleton.


sotagliflozin

An S-glycosyl compound that is 1-thio-beta-L-xylopyranose in which the anomeric hydroxy group is replaced by a 4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl group and the thiol is replaced by a methylsulfanediyl group. It is an inhibitor of SGLT1 and SGLT2 that is approved to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with heart failure or type 2 diabetes mellitus, chronic kidney disease, and other cardiovascular risk.


ELESCLOMOL

A carbohydrazide obtained by formal condensation of the carboxy groups of malonic acid with the hydrino groups of two molar equivalents of N-methylbenzenecarbothiohydrazide


GLRX1_HUMAN Glutaredoxin-1 (sprot)

A glutaredoxin-1 that is encoded in the genome of human.


neuromuscular disease

description: Any disease that impairs the functioning of the muscles, either directly, being pathologies of the voluntary muscle, or indirectly, being pathologies of nerves or neuromuscular junctions


Hypereosinophilia

description: A severely increased count of eosinophils in the blood defined as a blood eosinophil count of at least 1.5 billion cells per liter.


triamcinolone

A C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9. Used in the form of its 16,17-acetonide to treat various skin infections.


SPB13_HUMAN Serpin B13 (sprot)

A serpin B13 that is encoded in the genome of human.


name: HXC13_HUMAN Homeobox protein Hox-C13 (sprot)

description: A homeobox protein Hox-C13 that is encoded in the genome of human.


name: HXA13_HUMAN Homeobox protein Hox-A13 (sprot)

description: A homeobox protein Hox-A13 that is encoded in the genome of human.


chloroprocaine

Procaine in which one of the hydrogens ortho- to the carboxylic acid group is substituted by chlorine. It is used as its monohydrochloride salt as a local anaesthetic, particularly for oral surgery. It has the advantage over lidocaine of constricting blood vessels, so reducing bleeding.


pancreatic neoplasm

description: A benign or malignant neoplasm involving the pancreas.


diastolic heart failure

description: Heart failure caused by abnormal myocardial relaxation during diastole leading to defective cardiac filling.


Takayasu arteritis

description: A rare inflammatory large-vessel vasculitis primarily affecting the aorta and its major branches, but also other large vessels, causing stenosis, occlusion, or aneurysm.


KLK10_HUMAN Kallikrein-10 (sprot)

A kallikrein-10 that is encoded in the genome of human.


name: MARHB_HUMAN E3 ubiquitin-protein ligase MARCHF11 (sprot)

description: An E3 ubiquitin-protein ligase MARCHF11 that is encoded in the genome of human.


Charcot-Marie-Tooth disease

description: An inherited degenerative disorder involving the peripheral nerves. It is caused by mutations in the genes that are responsible for the production of proteins necessary for the function and structure of the peripheral nerves. It is characterized by muscle atrophy and weakness in the feet, legs, hands, and arms and loss of sensation in the limbs.


name: KCNE3_HUMAN Potassium voltage-gated channel subfamily E member 3 (sprot)

description: A potassium voltage-gated channel subfamily E member 3 that is encoded in the genome of human.


name: KCNE2_HUMAN Potassium voltage-gated channel subfamily E member 2 (sprot)

description: A potassium voltage-gated channel subfamily E member 2 that is encoded in the genome of human.


name: ODC_HUMAN Mitochondrial 2-oxodicarboxylate carrier (sprot)

description: A mitochondrial 2-oxodicarboxylate carrier that is encoded in the genome of human.


name: GRIP1_HUMAN Glutamate receptor-interacting protein 1 (sprot)

description: A glutamate receptor-interacting protein 1 that is encoded in the genome of human.


name: MEF2A_HUMAN Myocyte-specific enhancer factor 2A (sprot)

description: A myocyte-specific enhancer factor 2A that is encoded in the genome of human.


name: PDGFB_HUMAN Platelet-derived growth factor subunit B (sprot)

description: A platelet-derived growth factor subunit B that is encoded in the genome of human.


alitretinoin

A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.


name: RXRA_HUMAN Retinoic acid receptor RXR-alpha (sprot)

description: A retinoic acid receptor RXR-alpha that is encoded in the genome of human.


name: UCRI_HUMAN Cytochrome b-c1 complex subunit Rieske, mitochondrial (sprot)

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial that is encoded in the genome of human.


adrenomyeloneuropathy

description: An adult form of the peroxisomal disease X-linked adrenoleukodystrophy (X-ALD), characterized by spastic paraparesia and often associated with peripheral adrenal insufficiency in males. Both males and females can be affected with AMN.


hereditary fructose intolerance

description: Hereditary fructose intolerance (HFI) is an autosomal recessive disorder of fructose metabolism, resulting from a deficiency of hepatic fructose-1-phosphate aldolase activity and leading to gastrointestinal disorders and postprandial hypoglycemia following fructose ingestion. HFI is a benign condition when treated, but it is life-threatening and potentially fatal if left untreated.


raltegravir

A pyrimidone that is pyrimidin-4(3H)-one in which the hydrogens at positions 2, 3, 5 and 6 are replaced by 2-[(5-methyl-1,3,4-oxadiazole-2-carbonyl)amino]propan-2-yl, methyl, hydroxy, and N-[(4-fluorophenyl)methyl]aminoacyl groups, respectively. It is an antiretroviral drug used for treatment of HIV infection.


name: AICDA_HUMAN Single-stranded DNA cytosine deaminase (sprot)

description: A single-stranded DNA cytosine deaminase that is encoded in the genome of human.


ATX1_HUMAN Ataxin-1 (sprot)

An ataxin-1 that is encoded in the genome of human.


monensin

A spiroketal, monensin A is the major component of monensin, a mixture of antibiotic substances produced by Streptomyces cinnamonensis. An antiprotozoal, it is used as the sodium salt as a feed additive for the prevention of coccidiosis in poultry and as a growth promoter in cattle.


alginic acid

A linear copolymer macromolecule composed of homopolymeric blocks of 1->4-linked beta-D-mannuronic acid and alpha-L-guluronic acid residues, covalently linked together in different sequences or blocks.


name: MED29_HUMAN Mediator of RNA polymerase II transcription subunit 29 (sprot)

description: A mediator of RNA polymerase II transcription subunit 29 that is encoded in the genome of human.


dacomitinib

A member of the class of quinazolines that is 7-methoxyquinazoline-4,6-diamine in which the amino group at position 4 is substituted by a 3-chloro-4-fluorophenyl group and the amino group at position 6 is substituted by an (E)-4-(piperidin-1-yl)but-2-enoyl group.


enflurane

An ether in which the oxygen atom is connected to 2-chloro-1,1,2-trifluoroethyl and difluoromethyl groups.


MESODIHYDROGUAIARETIC ACID

A  lignan that is 2,3-dimethylbutane substituted by 2-methoxyphenol groups at positions 1 and 4 respectively. It has been isolated from the bark of Machilus robusta.


name: LIF_HUMAN Leukemia inhibitory factor (sprot)

description: A leukemia inhibitory factor that is encoded in the genome of human.


Large vessel vasculitis

description: A type of vasculitis (inflammation of blood vessel walls) affecting large arteries such as the aorta and branches of the aorta.


CATECHIN

Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.


name: PIM1_HUMAN Serine/threonine-protein kinase pim-1 (sprot)

description: A proto-oncogene serine/threonine-protein kinase Pim-1 that is encoded in the genome of human.


name: TAL2_HUMAN T-cell acute lymphocytic leukemia protein 2 (sprot)

description: A T-cell acute lymphocytic leukemia protein 2 that is encoded in the genome of human.


cervical carcinoma

description: A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma.


name: pyogenic arthritis-pyoderma gangrenosum-acne syndrome

description: A rare pleiotropic autoinflammatory disorder of childhood, primarily affecting the joints and skin.


name: AGRL3_HUMAN Adhesion G protein-coupled receptor L3 (sprot)

description: An adhesion G protein-coupled receptor L3 that is encoded in the genome of human.


name: VTI1B_HUMAN Vesicle transport through interaction with t-SNAREs homolog 1B (sprot)

description: A vesicle transport through interaction with t-SNAREs homolog 1B that is encoded in the genome of human.


FST_HUMAN Follistatin (sprot)

A follistatin that is encoded in the genome of human.


name: SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (sprot)

description: An NAD-dependent deacetylase sirtuin-5 that is encoded in the genome of human.


KNG1_HUMAN Kininogen-1 (sprot)

A kininogen-1 that is encoded in the genome of human.


tranylcypromine

A member of the class of cyclopropanes carrying amino and phenyl substituents at positions 1 and 2 respectively.


CAN6_HUMAN Calpain-6 (sprot)

A calpain-6 that is encoded in the genome of human.


hepatorenal syndrome

description: Hepatorenal syndrome is a form of impaired kidney function that occurs in individuals with advanced chronic liver disease. As many as 40% of individuals with cirrhosis and ascites will develop hepatorenal syndrome. Symptoms may include fatigue, abdominal pain, and a general feeling of ill health (malaise). There are two distinct types of hepatorenal syndrome. Type I progresses quickly (within days), leading to kidney failure. Individuals with type I typically have dramatically reduced urine output, edema, and jaundice, and often suffer from hepatic encephalopathy. Type II progresses more slowly, over weeks or months, and the symptoms are less severe. The cause of hepatorenal syndrome is unknown. A contributing factor seems to be a narrowing of the blood vessels that connect into the kidneys. This causes a decrease in blood flow to the kidneys, impairing their function. In some cases, triggers or precipitating factors (infections, blood loss from the gastrointestinal tract, low blood pressure) are involved. Treatment is aimed at helping the liver work better and maintaining kidney function. In many cases, a liver transplant is needed. In some cases, individuals also need a kidney transplant.


Abnormal renal physiology

description: An abnormal functionality of the kidney.


name: OGG1_HUMAN N-glycosylase/DNA lyase (sprot)

description: An N-glycosylase/DNA lyase that is encoded in the genome of human.


octyl beta-D-glucopyranoside

An beta-D-glucoside in which the anomeric hydrogen of beta-D-glucopyranose is substituted by an octyl group.


name: TNI3K_HUMAN Serine/threonine-protein kinase TNNI3K (sprot)

description: A serine/threonine-protein kinase TNNI3K that is encoded in the genome of human.


AMINOLEVULINIC ACID HYDROCHLORIDE

A hydrochloride that is the monohydrochloride of 5-aminolevulinic acid. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.


name: AT2B4_HUMAN Plasma membrane calcium-transporting ATPase 4 (sprot)

description: A plasma membrane calcium-transporting ATPase 4 that is encoded in the genome of human.


name: ROMO1_HUMAN Reactive oxygen species modulator 1 (sprot)

description: A reactive oxygen species modulator 1 that is encoded in the genome of human.


ischemic bowel disorder

description: Disease of the large or small intestine that is caused by inadequate blood supply.


proliferative diabetic retinopathy

description: Advanced retinopathy due to diabetes mellitus characterized by the formation of new vessels in the retina. The new vessels are abnormal and fragile. If hemorrhage occurs due to the vascular fragility, there is increased risk of vision loss or blindness.


name: SCTM1_HUMAN Secreted and transmembrane protein 1 (sprot)

description: A secreted and transmembrane protein 1 that is encoded in the genome of human.


name: CDX2_HUMAN Homeobox protein CDX-2 (sprot)

description: A homeobox protein CDX-2 that is encoded in the genome of human.


Nocturnal hypoxemia

description: Abnormally reduced oxyhemoglobin saturation during sleep (nocturnal). Different thresholds are used in the literature, including more than 10 percent of total sleep time below a SpO2 of 90 percent.


name: TFR1_HUMAN Transferrin receptor protein 1 (sprot)

description: A transferrin receptor protein 1 that is encoded in the genome of human.


name: KDM4C_HUMAN Lysine-specific demethylase 4C (sprot)

description: A lysine-specific demethylase 4C that is encoded in the genome of human.


name: PDIA3_HUMAN Protein disulfide-isomerase A3 (sprot)

description: A protein disulfide-isomerase A3 that is encoded in the genome of human.


CYCLOLEUCINE

A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.


name: PSME3_HUMAN Proteasome activator complex subunit 3 (sprot)

description: A proteasome activator complex subunit 3 that is encoded in the genome of human.


drug-induced methemoglobinemia

description: Methemoglobinemia that is caused by exposure to certain drugs (xylocaine and benzene).


name: PAN2_HUMAN PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (sprot)

description: A PAN2-PAN3 deadenylation complex catalytic subunit PAN2 that is encoded in the genome of human.


name: TRI39_HUMAN E3 ubiquitin-protein ligase TRIM39 (sprot)

description: An E3 ubiquitin-protein ligase TRIM39 that is encoded in the genome of human.


lamivudine

A monothioacetal that consists of cytosine having a (2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl moiety attached at position 1. An inhibitor of HIV-1 reverse transcriptase, it is used as an antiviral in the treatment of AIDS and hepatitis B.


cefditoren

A broad spectrum, third-generation cephalosporin antibiotic with (Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. Generally administered as its orally absorbed pivaloyloxymethyl ester prodrug, it is used for the treatment of mild to moderate infections caused by susceptible strains of microorganisms in acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, pharyngitis/tonsillitis, and uncomplicated skin and skin-structure infections.


Arthralgia

description: Joint pain.


eritoran

A lipid A derivative used for the treatment of severe sepsis.


LUPEOL

A pentacyclic triterpenoid that is lupane in which the hydrogen at the 3beta position is substituted by a hydroxy group. It occurs in the skin of lupin seeds, as well as in the latex of fig trees and of rubber plants. It is also found in many edible fruits and vegetables.


hepatoblastoma

description: Hepatoblastoma (HB) is a malignant hepatic tumor and is the most common pediatric liver cancer. It is characterized by anorexia, weight loss and an enlarged abdomen. HB is more common in patients with familial adenomatous polyposis (FAP), and can occur in patients with other pre-existing liver conditions. About 5% of HB cases are associated with genetic factors, especially overgrowth syndromes, such as Beckwith-Wiedemann syndrome (BWS) or hemihypertrophy.


encephalitis

description: An acute inflammatory process affecting the brain parenchyma. Causes include viral infections and less frequently bacterial infections, toxins, and immune-mediated processes.


name: ERBB4_HUMAN Receptor tyrosine-protein kinase erbB-4 (sprot)

description: A receptor tyrosine-protein kinase erbB-4 that is encoded in the genome of human.


name: MDHM_HUMAN Malate dehydrogenase, mitochondrial (sprot)

description: A malate dehydrogenase, mitochondrial that is encoded in the genome of human.


name: MED22_HUMAN Mediator of RNA polymerase II transcription subunit 22 (sprot)

description: A mediator of RNA polymerase II transcription subunit 22 that is encoded in the genome of human.


name: FHR3_HUMAN Complement factor H-related protein 3 (sprot)

description: A complement factor H-related protein 3 that is encoded in the genome of human.


name: S27A4_HUMAN Long-chain fatty acid transport protein 4 (sprot)

description: A long-chain fatty acid transport protein 4 that is encoded in the genome of human.


MON2_HUMAN Protein MON2 homolog (sprot)

A protein MON2 that is encoded in the genome of human.


EST2_HUMAN Cocaine esterase (sprot)

A cocaine esterase that is encoded in the genome of human.


name: HES5_HUMAN Transcription factor HES-5 (sprot)

description: A transcription factor HES-5 that is encoded in the genome of human.


name: PRP6_HUMAN Pre-mRNA-processing factor 6 (sprot)

description: A pre-mRNA-processing factor 6 that is encoded in the genome of human.


papilloma

description: A benign epithelial neoplasm that projects above the surrounding epithelial surface and consists of villous or arborescent outgrowths of fibrovascular stroma.


CD52_HUMAN CAMPATH-1 antigen (sprot)

A CAMPATH-1 antigen that is encoded in the genome of human.


CDCA5_HUMAN Sororin (sprot)

A sororin that is encoded in the genome of human.


name: CHST2_HUMAN Carbohydrate sulfotransferase 2 (sprot)

description: A carbohydrate sulfotransferase 2 that is encoded in the genome of human.


tonsillitis

description: Inflammation of the tonsillar tissue.


name: NAT8_HUMAN N-acetyltransferase 8 (sprot)

description: An N-acetyltransferase 8 that is encoded in the genome of human.


name: FOXD1_HUMAN Forkhead box protein D1 (sprot)

description: A forkhead box protein D1 that is encoded in the genome of human.


dihydroartemisinin

A sesquiterpenoid compound which is used as a drug for treatment of malaria.


name: TCTP_HUMAN Translationally-controlled tumor protein (sprot)

description: A translationally-controlled tumor protein that is encoded in the genome of human.


name: ETV4_HUMAN ETS translocation variant 4 (sprot)

description: An ETS translocation variant 4 that is encoded in the genome of human.


maple syrup urine disease

description: An autosomal recessive inherited disorder caused by mutations in the BCKDHA, BCKDHB, DBT, and DLD genes. It is characterized by a deficiency of branched-chain alpha-keto acid dehydrogenase complex, leading to accumulation of metabolites in the body fluids. The name of the disease derives from the sweet odor of the urine in infants, reminiscent of maple syrup. Signs and symptoms usually appear in infancy and include lethargy and developmental delays. If untreated, it may lead to seizures, coma, and death.


MUC5B_HUMAN Mucin-5B (sprot)

A mucin-5B that is encoded in the genome of human.


name: ATF6B_HUMAN Cyclic AMP-dependent transcription factor ATF-6 beta (sprot)

description: A cyclic AMP-dependent transcription factor ATF-6 beta that is encoded in the genome of human.


name: UBIP1_HUMAN Upstream-binding protein 1 (sprot)

description: An upstream-binding protein 1 that is encoded in the genome of human.


name: ASIC3_HUMAN Acid-sensing ion channel 3 (sprot)

description: An acid-sensing ion channel 3 that is encoded in the genome of human.


name: NOXA1_HUMAN NADPH oxidase activator 1 (sprot)

description: An NADPH oxidase activator 1 that is encoded in the genome of human.


name: SF3B3_HUMAN Splicing factor 3B subunit 3 (sprot)

description: A splicing factor 3B subunit 3 that is encoded in the genome of human.


CTND1_HUMAN Catenin delta-1 (sprot)

A catenin delta-1 that is encoded in the genome of human.


masoprocol

The meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase.


INVO_HUMAN Involucrin (sprot)

An involucrin that is encoded in the genome of human.


name: Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2


name: REST_HUMAN RE1-silencing transcription factor (sprot)

description: An RE1-silencing transcription factor that is encoded in the genome of human.


crotylaldehyde

An enal consisting of propene having a formyl group at the 1-position.


craniosynostosis

description: Craniosynostosis is defined as the premature fusion of one or more cranial sutures leading to secondary distortion of skull shape resulting in skull deformities with a variable presentation. Craniosynostosis may occur in an isolated setting or as part of a syndrome.


name: GPX1_HUMAN Glutathione peroxidase 1 (sprot)

description: A glutathione peroxidase 1 that is encoded in the genome of human.


name: ELL2_HUMAN RNA polymerase II elongation factor ELL2 (sprot)

description: An RNA polymerase II elongation factor ELL2 that is encoded in the genome of human.


name: MASP1_HUMAN Mannan-binding lectin serine protease 1 (sprot)

description: A mannan-binding lectin serine protease 1 that is encoded in the genome of human.


PEPSTATIN

A pentapeptide isolated from Streptomyces testaceus. It is a potent inhibitor of aspartyl proteases.


BTC_HUMAN Probetacellulin (sprot)

A probetacellulin that is encoded in the genome of human.


cystadenocarcinoma

description: A malignant cystic epithelial neoplasm arising from the glandular epithelium. The malignant epithelial cells invade the stroma. The cystic spaces contain serous or mucinous fluid. Representative examples include ovarian and pancreatic cystadenocarcinomas.


MONOETHANOLAMINE

A member of the class of  ethanolamines that is ethane with an amino substituent at C-1 and a hydroxy substituent at C-2, making it both a primary amine and a primary alcohol.


triphenylmethane

A triarylmethane in which the three aryl groups are phenyl. It forms the basic skeleton of several synthetic dyes.


Chronic fatigue

description: Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer.


name: SOAT1_HUMAN Sterol O-acyltransferase 1 (sprot)

description: A sterol O-acyltransferase 1 that is encoded in the genome of human.


CAH4_HUMAN Carbonic anhydrase 4 (sprot)

A carbonic anhydrase 4 that is encoded in the genome of human.


name: Recurrent lower respiratory tract infections

description: An increased susceptibility to lower respiratory tract infections as manifested by a history of recurrent lower respiratory tract infections.


name: PSG2_HUMAN Pregnancy-specific beta-1-glycoprotein 2 (sprot)

description: A pregnancy-specific beta-1-glycoprotein 2 that is encoded in the genome of human.


tiratricol

A monocarboxylic acid that is (4-hydroxy-3,5-diiodophenyl)acetic acid in which the phenolic hydroxy group has been replaced by a 4-hydroxy-3-iodophenoxy group. It is a thyroid hormone analogue that has been used in the treatment of thyroid hormone resistance syndrome.


name: ZGRF1_HUMAN 5'-3' DNA helicase ZGRF1 (sprot)

description: A protein that is a translation product of the ZGRF1 gene in human.


warfarin

A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.


name: SPO11_HUMAN Meiotic recombination protein SPO11 (sprot)

description: A meiotic recombination protein SPO11 that is encoded in the genome of human.


name: RAB1B_HUMAN Ras-related protein Rab-1B (sprot)

description: A Ras-related protein Rab-1B that is encoded in the genome of human.


name: MKNK1_HUMAN MAP kinase-interacting serine/threonine-protein kinase 1 (sprot)

description: A MAP kinase-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human.


name: REXO1_HUMAN RNA exonuclease 1 homolog (sprot)

description: An RNA exonuclease 1 that is encoded in the genome of human.


name: DIP2A_HUMAN Disco-interacting protein 2 homolog A (sprot)

description: A disco-interacting protein 2 homolog A that is encoded in the genome of human.


josamycin

A macrolide antibiotic produced by certain strains of Streptomyces narbonensis var. josamyceticus.


name: RECK_HUMAN Reversion-inducing cysteine-rich protein with Kazal motifs (sprot)

description: A reversion-inducing cysteine-rich protein with Kazal motifs that is encoded in the genome of human.


Hashimoto thyroiditis

description: An autoimmune disorder caused by the production of autoantibodies against thyroid tissue. There is progressive destruction of the thyroid follicles leading to hypothyroidism.


name: ARHG1_HUMAN Rho guanine nucleotide exchange factor 1 (sprot)

description: A Rho guanine nucleotide exchange factor 1 that is encoded in the genome of human.


name: MMP19_HUMAN Matrix metalloproteinase-19 (sprot)

description: A matrix metalloproteinase-19 that is encoded in the genome of human.


Deep venous thrombosis

description: Formation of a blot clot in a deep vein. The clot often blocks blood flow, causing swelling and pain. The deep veins of the leg are most often affected.


name: BACD3_HUMAN BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (sprot)

description: A BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 that is encoded in the genome of human.


name: RASA1_HUMAN Ras GTPase-activating protein 1 (sprot)

description: A Ras GTPase-activating protein 1 that is encoded in the genome of human.


periciazine

A member of the class of  phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic.


name: S23A1_HUMAN Solute carrier family 23 member 1 (sprot)

description: A solute carrier family 23 member 1 that is encoded in the genome of human.


name: S23A2_HUMAN Solute carrier family 23 member 2 (sprot)

description: A solute carrier family 23 member 2 that is encoded in the genome of human.


ataxia telangiectasia

description: Ataxia-telangiectasia is the association of severe combined immunodeficiency (affecting mainly the humoral immune response) with progressive cerebellar ataxia. It is characterized by neurological signs, telangiectasias, increased susceptibility to infections and a higher risk of cancer.


hydrofluoric acid

A diatomic molecule containing covalently bonded hydrogen and fluorine atoms.


post-traumatic stress disorder

description: An anxiety disorder precipitated by an experience of intense fear or horror while exposed to a traumatic (especially life-threatening) event. The disorder is characterized by intrusive recurring thoughts or images of the traumatic event; avoidance of anything associated with the event; a state of hyperarousal and diminished emotional responsiveness. These symptoms are present for at least one month and the disorder is usually long-term.


ITA3_HUMAN Integrin alpha-3 (sprot)

An integrin alpha-3 that is encoded in the genome of human.


name: BUB1_HUMAN Mitotic checkpoint serine/threonine-protein kinase BUB1 (sprot)

description: A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human.


vulvar melanoma

description: A usually pigmented, nodular or polypoid malignant neoplasm that originates from melanocytes and arises from the vulva. It presents with bleeding and dysuria.


norfloxacin

A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.


name: S47A1_HUMAN Multidrug and toxin extrusion protein 1 (sprot)

description: A multidrug and toxin extrusion protein 1 that is encoded in the genome of human.


name: MK12_HUMAN Mitogen-activated protein kinase 12 (sprot)

description: A mitogen-activated protein kinase 12 that is encoded in the genome of human.


name: GCP2_HUMAN Gamma-tubulin complex component 2 (sprot)

description: A gamma-tubulin complex component 2 that is encoded in the genome of human.


name: RS4X_HUMAN Small ribosomal subunit protein eS4, X isoform (sprot)

description: A small ribosomal subunit protein eS4, X isoform that is encoded in the genome of human.


adenine

The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6.


risperidone

A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.


levobupivacaine

The (S)-(-)-enantiomer of bupivacaine.


lip cancer

description: A primary or metastatic malignant neoplasm involving the lip.


verapamil hydrochloride

A racemate comprising equimolar amounts of dexverapamil hydrochloride and (S)-verapamil hydrochloride.


name: JAK1_HUMAN Tyrosine-protein kinase JAK1 (sprot)

description: A tyrosine-protein kinase JAK1 that is encoded in the genome of human.


name: SERC_HUMAN Phosphoserine aminotransferase (sprot)

description: A phosphoserine aminotransferase that is encoded in the genome of human.


name: SYDM_HUMAN Aspartate--tRNA ligase, mitochondrial (sprot)

description: An aspartate--tRNA ligase, mitochondrial that is encoded in the genome of human.


ditiocarb

A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur.


INF2_HUMAN Inverted formin-2 (sprot)

An inverted formin-2 that is encoded in the genome of human.


Marchiafava-Bignami disease

description: Marchiafava Bignami disease is defined by characteristic demyelination of the corpus callosum (erosion of the protective covering of nerve fibers joining the 2 hemispheres of the brain). The disease seems to most often affect severe and chronic alcoholics in their middle or late adult life. Early symptoms may include depression, paranoia, psychosis, or dementia. Seizures are common, and hemiparesis, aphasia, abnormal movements, and ataxia may sometimesprogress to coma and/or death. The cause of Marchiafava Bignami disease, including the potential role of nutritional deficiency, remains unknown. Improvement and recovery of some individuals has been reported. Treatment focuses on nutritional support and rehabilitation from alcoholism.


name: GRM1_HUMAN Metabotropic glutamate receptor 1 (sprot)

description: A metabotropic glutamate receptor 1 that is encoded in the genome of human.


name: NU153_HUMAN Nuclear pore complex protein Nup153 (sprot)

description: A nuclear pore complex protein Nup153 that is encoded in the genome of human.


PRS58_HUMAN Serine protease 58 (sprot)

A serine protease 58 that is encoded in the genome of human.


name: M3K1_HUMAN Mitogen-activated protein kinase kinase kinase 1 (sprot)

description: A mitogen-activated protein kinase kinase kinase 1 that is encoded in the genome of human.


thioguanine

A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia.


VWF_HUMAN von Willebrand factor (sprot)

A von Willebrand factor that is encoded in the genome of human.


name: INSI2_HUMAN Insulin-induced gene 2 protein (sprot)

description: An insulin-induced gene 2 protein that is encoded in the genome of human.


name: CSDE1_HUMAN Cold shock domain-containing protein E1 (sprot)

description: A cold shock domain-containing protein E1 that is encoded in the genome of human.


name: TRA2B_HUMAN Transformer-2 protein homolog beta (sprot)

description: A transformer-2 protein homolog beta that is encoded in the genome of human.


name: NIM1_HUMAN Serine/threonine-protein kinase NIM1 (sprot)

description: A serine/threonine-protein kinase NIM1 that is encoded in the genome of human.


name: NOD1_HUMAN Nucleotide-binding oligomerization domain-containing protein 1 (sprot)

description: A nucleotide-binding oligomerization domain-containing protein 1 that is encoded in the genome of human.


name: CAB39_HUMAN Calcium-binding protein 39 (sprot)

description: A calcium-binding protein 39 that is encoded in the genome of human.


TOB1_HUMAN Protein Tob1 (sprot)

A protein Tob1 that is encoded in the genome of human.


pelvic inflammatory disease

description: Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity. It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. PID may be either symptomatic or asymptomatic. It may cause infertility and it may raise the risk of ectopic pregnancy. PID is a disease associated with HIV infection.


name: CXCL6_HUMAN C-X-C motif chemokine 6 (sprot)

description: A C-X-C motif chemokine 6 that is encoded in the genome of human.


name: S12A1_HUMAN Solute carrier family 12 member 1 (sprot)

description: A solute carrier family 12 member 1 that is encoded in the genome of human.


name: PLCB2_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (sprot)

description: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 that is encoded in the genome of human.


visual snow syndrome

description: Visual snow syndrome is described as a persistent visual problem characterized by seeing snow-like dots. Migraines are a common symptom. Many people also see drifting blobs of varying size and shape (floaters), visual effects (entopic phenomenon), glare, halos, starbursts, trails, odd colors and shapes, and may have persistent recurrence of a visual image (palinopsia) and double vision. Additional symptoms may include fatigue, tinnitus, or depersonalization and depression. Most people have normal vision tests and normal brain images. Standard migraine treatments are often not helpful. There is no cure or effective treatment to completely relieve the symptoms, but medication seems to help some people with visual snow.


name: CEBPE_HUMAN CCAAT/enhancer-binding protein epsilon (sprot)

description: A CCAAT/enhancer-binding protein epsilon that is encoded in the genome of human.


semaglutide

A polypeptide that contains a linear sequence of 31 amino acids joined together by peptide linkages. It is an agonist of glucagon-like peptide-1 receptors (GLP-1 AR) and used for the treatment of type 2 diabetes.


CP7B1_HUMAN Cytochrome P450 7B1 (sprot)

A cytochrome P450 7B1 that is encoded in the genome of human.


diffuse lymphatic malformation

description: A rare developmental defect during embryogenesis characterized by multifocal dilated lymphatic vessels involving multiple organs and tissues. Patients mostly present in infancy and childhood. Clinical course and prognosis depend on the affected sites and extent of the condition, deterioration of lung function being a major cause of morbidity and mortality.


name: RPA2_HUMAN DNA-directed RNA polymerase I subunit RPA2 (sprot)

description: A DNA-directed RNA polymerase I subunit RPA2 that is encoded in the genome of human.


name: CO5A2_HUMAN Collagen alpha-2(V) chain (sprot)

description: A collagen alpha-2(V) chain that is encoded in the genome of human.


sparsentan

A biphenyl that is 1,1'-biphenyl substituted by (4,5-dimethyl-1,2-oxazol-3-yl)aminosulfonyl, ethoxymethyl, and (2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl groups at positions 2, 2' and 4', respectively. It is a dual antagonist of endothelin and angiotensin II receptors approved for the reduction of proteinuria in adults with primary immunoglobulin A nephropathy at risk of rapid disease progression.


focal segmental glomerulosclerosis

description: A renal disorder characterized by sclerotic lesions in the glomeruli. Causes include drugs, viruses, and malignancies (lymphomas), or it may be idiopathic. It presents with asymptomatic proteinuria or nephritic syndrome and it may lead to renal failure.


erectile dysfunction

description: Persistent or recurrent inability to achieve or to maintain an erection during sexual activity.


name: ERF3A_HUMAN Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (sprot)

description: A eukaryotic peptide chain release factor GTP-binding subunit ERF3A that is encoded in the genome of human.


name: FGF21_HUMAN Fibroblast growth factor 21 (sprot)

description: A fibroblast growth factor 21 that is encoded in the genome of human.


CLUS_HUMAN Clusterin (sprot)

A clusterin that is encoded in the genome of human.


betaine

The amino acid betaine derived from glycine.


NU 1025

A member of the class of  quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against  poly(ADP-ribose) polymerase.


PROP_HUMAN Properdin (sprot)

A properdin that is encoded in the genome of human.


LMAN1_HUMAN Protein ERGIC-53 (sprot)

A protein ERGIC-53 that is encoded in the genome of human.


name: OSBL1_HUMAN Oxysterol-binding protein-related protein 1 (sprot)

description: An oxysterol-binding protein-related protein 1 that is encoded in the genome of human.


name: atypical chronic myeloid leukemia, BCR-ABL1 negative

description: A myelodysplastic/myeloproliferative neoplasm characterized by the principal involvement of the neutrophil series with leukocytosis and multilineage dysplasia. The neoplastic cells do not have a Philadelphia chromosome or the BCR/ABL fusion gene. (WHO, 2001)


A member of the class of pryrazoles that is 4-amino-1H-pyrazole-3-carboxylic acid in which the primary amino group has been acylated by a 2,6-dichlorobenzoyl group and in which the carboxylic acid has been converted into a carboxamide by formal condensation with the primary amino group of 4-aminopiperidine.


name: ATG10_HUMAN Ubiquitin-like-conjugating enzyme ATG10 (sprot)

description: A ubiquitin-like-conjugating enzyme ATG10 that is encoded in the genome of human.


name: KAPCA_HUMAN cAMP-dependent protein kinase catalytic subunit alpha (sprot)

description: A cAMP-dependent protein kinase catalytic subunit alpha that is encoded in the genome of human.


name: TS1R1_HUMAN Taste receptor type 1 member 1 (sprot)

description: A taste receptor type 1 member 1 that is encoded in the genome of human.


name: TS1R2_HUMAN Taste receptor type 1 member 2 (sprot)

description: A taste receptor type 1 member 2 that is encoded in the genome of human.


name: CCL7_HUMAN C-C motif chemokine 7 (sprot)

description: A C-C motif chemokine 7 that is encoded in the genome of human.


name: IF5A1_HUMAN Eukaryotic translation initiation factor 5A-1 (sprot)

description: A eukaryotic translation initiation factor 5A-1 that is encoded in the genome of human.


erythromelalgia

description: A rare neurovascular peripheral pain disorder due to the intermittent blockage of the blood vessels, usually in the lower extremities or hands. This causes hyperemia and inflammation at the origin of burning pain and skin redness. The attacks are periodic and are commonly triggered by heat, pressure, mild activity, exertion, insomnia or stress. Erythromelalgia may occur either as a primary or secondary disorder. Primary erythromelalgia is caused by gene mutations. Secondary erythromelalgia can result from small fiber peripheral neuropathy of any cause, essential thrombocytemia, hypercholesterolemia, mushroom or mercury poisoning, and some autoimmune disorders.


chloral hydrate

An organochlorine compound that is the hydrate of trichloroacetaldehyde.


chondrosarcoma

description: A malignant cartilaginous matrix-producing mesenchymal neoplasm arising from the bone and soft tissue. It usually affects middle-aged to elderly adults. The pelvic bones, ribs, shoulder girdle, and long bones are the most common sites of involvement. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion.


central nervous system neoplasm

description: A benign or malignant, primary or metastatic neoplasm that affects the brain, meninges, or spinal cord. Representative examples of primary neoplasms include astrocytoma, oligodendroglioma, ependymoma, and meningioma. Representative examples of metastatic neoplasms include carcinoma and leukemia.


theobromine

A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.


name: CHD1_HUMAN Chromodomain-helicase-DNA-binding protein 1 (sprot)

description: A chromodomain-helicase-DNA-binding protein 1 that is encoded in the genome of human.


name: LPIN1_HUMAN Phosphatidate phosphatase LPIN1 (sprot)

description: A phosphatidate phosphatase LPIN1 that is encoded in the genome of human.


name: NPC1_HUMAN NPC intracellular cholesterol transporter 1 (sprot)

description: An NPC intracellular cholesterol transporter 1 that is encoded in the genome of human.


name: KI20B_HUMAN Kinesin-like protein KIF20B (sprot)

description: A kinesin-like protein KIF20B that is encoded in the genome of human.


name: KIF4A_HUMAN Chromosome-associated kinesin KIF4A (sprot)

description: A chromosome-associated kinesin KIF4A that is encoded in the genome of human.


name: LHX3_HUMAN LIM/homeobox protein Lhx3 (sprot)

description: A LIM/homeobox protein Lhx3 that is encoded in the genome of human.


name: myelodysplastic syndrome with ring sideroblasts

description: Acquired idiopathic sideroblastic anemia is one of a group of disorders known as the myelodysplastic syndromes (MDS) characterized by ineffective haemopoiesis affecting one or more blood cell lineages (myeloid, erythroid or megakaryocytic) leading to peripheral blood cytopenias and an increased risk of developing leukemia. Acquired idiopathic sideroblastic anemia is now more commonly referred to as refractory anemia with ringed sideroblasts or the acronym RARS.


name: congenital dyserythropoietic anemia type 1

description: Congenital dyserythropoietic anemiatype I (CDA I) is a hematologic disorder of erythropoiesis characterized by moderate to severe macrocytic anemia occasionally associated with limb or nail deformities and scoliosis.


rilpivirine

An aminopyrimidine that is pyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 4-cyanophenyl and 4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl groups respectively. Used for treatment of HIV.


name: CXCR1_HUMAN C-X-C chemokine receptor type 1 (sprot)

description: A C-X-C chemokine receptor type 1 that is encoded in the genome of human.


indole-3-propionic acid

An  indol-3-yl carboxylic acid that is  propionic acid substituted by a 1H-indol-3-yl group at position 3.


streptomycin

A amino cyclitol glycoside that consists of streptidine having a disaccharyl moiety attached at the 4-position. The parent of the streptomycin class


spondyloarthropathy

description: A group of inflammatory rheumatic diseases associated with arthritis and enthesitis, and often involving the axial skeleton. The most common form of spondyloarthritis is ankylosing spondylitis. Other forms include axial spondyloarthritis, peripheral spondyloarthritis, reactive arthritis, psoriatic arthritis/spondylitis and enteropathic arthritis/spondylitis.


Cognitive impairment

description: Abnormal cognition is characterized by deficits in thinking, reasoning, or remembering.


name: SNIP1_HUMAN Smad nuclear-interacting protein 1 (sprot)

description: A smad nuclear-interacting protein 1 that is encoded in the genome of human.


name: AFAP1_HUMAN Actin filament-associated protein 1 (sprot)

description: An actin filament-associated protein 1 that is encoded in the genome of human.


name: CIB1_HUMAN Calcium and integrin-binding protein 1 (sprot)

description: A calcium and integrin-binding protein 1 that is encoded in the genome of human.


hepatosplenic T-cell lymphoma

description: An extranodal, mature T-cell non-Hodgkin lymphoma that originates from cytotoxic T-cells, usually of gamma/delta T-cell type. It is characterized by the presence of medium-size neoplastic lymphocytes infiltrating the hepatic sinusoids. A similar infiltrating pattern is also present in the spleen and bone marrow that are usually involved at the time of the diagnosis.


name: BSPH1_HUMAN Binder of sperm protein homolog 1 (sprot)

description: A binder of sperm protein homolog 1 that is encoded in the genome of human.


Sleep abnormality

description: An abnormal pattern in the quality, quantity, or characteristics of sleep.


A hydroxyflavonoid in which the flavone nucleus is substituted at position 7 by a hydroxy group.


A N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide in which the double bond adopts a trans-configuration.


name: CD8B_HUMAN T-cell surface glycoprotein CD8 beta chain (sprot)

description: A T-cell surface glycoprotein CD8 beta chain that is encoded in the genome of human.


name: PRP17_HUMAN Pre-mRNA-processing factor 17 (sprot)

description: A pre-mRNA-processing factor 17 that is encoded in the genome of human.


graft versus host disease

description: An immune system disorder that occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen.


CD276_HUMAN CD276 antigen (sprot)

A CD276 molecule that is encoded in the genome of human.


name: FCGR1_HUMAN High affinity immunoglobulin gamma Fc receptor I (sprot)

description: A high affinity immunoglobulin gamma Fc receptor I that is encoded in the genome of human.


citalopram

A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer,  escitalopram. It is used as an antidepressant, although only escitalopram is active.


malignant testicular germ cell tumor

description: A malignant tumor predominantly affecting young men and often associated with cryptorchidism. Seminoma is the most frequently seen malignant testicular germ cell tumor, followed by embryonal carcinoma and yolk sac tumor.


name: XPF_HUMAN DNA repair endonuclease XPF (sprot)

description: A DNA repair endonuclease XPF that is encoded in the genome of human.


name: APH1A_HUMAN Gamma-secretase subunit APH-1A (sprot)

description: A gamma-secretase subunit APH-1A that is encoded in the genome of human.


name: FEM1B_HUMAN Protein fem-1 homolog B (sprot)

description: A protein fem-1 homolog B that is encoded in the genome of human.


POSTN_HUMAN Periostin (sprot)

A periostin that is encoded in the genome of human.


name: CP2CJ_HUMAN Cytochrome P450 2C19 (sprot)

description: A cytochrome P450 2C19 that is encoded in the genome of human.


Short stature

description: A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to "short stature" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms).


name: SFRP1_HUMAN Secreted frizzled-related protein 1 (sprot)

description: A secreted frizzled-related protein 1 that is encoded in the genome of human.