Hypothalamic Gangliocytoma

description: A tumor characterized by the presence of mature ganglion cells and neuronal differentiation, arising in the hypothalamus. It is often associated with the presence of pituitary gland adenomas. Symptoms include acromegaly and precocious puberty.


AIDS-Related Cervical Carcinoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A carcinoma that arises from the cervix in a patient with acquired immunodeficiency syndrome.


P1 Hydronephrosis

description: Postnatal Hydronephrosis with the following clinical findings: 1) APRPD is 10 to less than 15 mm, 2) central calyceal dilation may be present, but peripheral calyceal dilation is considered to increase risk, 3) renal parenchyma should have normal thickness and appearance, 4) the ureter is not seen, and 5) the bladder is normal. If there is central calyceal dilation but the APRPD is less than 10 mm, it is still considered UTD P1. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


name: Acute Myeloid Leukemia with t(4;11)(q21.3;q23.3); AFF1-KMT2A

description: An acute myeloid leukemia associated with t(4;11)(q21.3;q23.3) resulting in AFF1-KMT2A gene fusion.


name: Psoriatic arthritis with distal interphalangeal joint involvement

description: Psoriatic arthritis with a particular pattern of involvement that affects the joints closest to the nails in both fingers and toes.


name: Hereditary Transthyretin Amyloid Cardiomyopathy

description: Transthyretin amyloid cardiomyopathy caused by mutation(s) in the TTR gene, encoding transthyretin.


Acute Myeloid Leukemia with BCOR-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of BCOR-RARA fusion protein.


Childhood Endocrine Neoplasm

description: A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ during childhood.


Stage IA Pancreatic Cancer AJCC v8

description: Stage IA includes: T1, N0, M0. T1: Tumor measuring 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Childhood Acute Lymphoblastic Leukemia CNS-Positive Toronto Guidelines v2

description: Clinical signs of CNS involvement or blasts in CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Substance Intoxication Delirium

description: A disorder characterized by the acute and sudden development of changes in attention, memory, language and/or perception that can be etiologically linked to the direct physiological consequences of substance intoxication.


name: Stage IIIA Uterine Corpus Cancer AJCC v7

description: Stage IIIA includes: T3a, N0, M0.  T3a: Tumor involves serosa and/or adnexa (direct extension or metastasis). N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


name: Cutaneous Hematopoietic and Lymphoid Cell Neoplasm

description: A neoplasm of hematopoietic and lymphoid cell origin that affects the skin.


name: Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: An undifferentiated high grade pleomorphic sarcoma that arises from the bone and occurs during adulthood.


Early Stage Malignant Skin Neoplasm

description: A stage term that refers to a malignant tumor confined to a limited area of the skin without lymph node or distant metastases.


name: Acute Myeloid Leukemia with SRSF2 Mutation

description: An acute myeloid leukemia associated with SRSF2 gene mutation.


Stage IV Vulvar Cancer AJCC v8

description: Stage IV includes: T1-T3, N3, M0-M1. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). T3: Tumor of any size with extension to any of the following: upper/proximal two-thirds of the urethra, upper/proximal two-thirds of the vagina, bladder mucosa, or rectal mucosa; or fixed to pelvic bone. N3: Fixed or ulcerated regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis (including pelvic lymph node metastasis). (from AJCC 8th Ed.)


Locally Advanced Lymphoma

description: Lymphoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: High Grade Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is high-grade.


Conditioned Insomnia

description: Insomnia that results from a developed tendency to not sleep well under particular conditions.


Broad Ligament Serous Cystadenoma

description: A rare serous cystadenoma arising from the broad ligament.


name: Refractory Non-Muscle Invasive Bladder Carcinoma

description: Non-muscle invasive bladder carcinoma that is resistant to treatment.


Childhood Dermal Nevus

description: A dermal nevus that occurs during childhood.


name: Adenocarcinoma in situ in villous adenoma

description: A non-invasive adenocarcinoma arising from a villous adenoma.


Childhood Gemistocytic Astrocytoma

description: A gemistocytic astrocytoma that occurs during childhood.


Vaginal Mesonephric Adenocarcinoma

description: Vaginal adenocarcinoma that derives from Wolffian duct remnants and shows mesonephric differentiation.


Adult Acquired Toxoplasmosis

description: Toxoplasmosis acquired in adulthood.


High Grade Sarcoma

description: A sarcoma with the morphologic features of a high-grade tumor and lack of cellular differentiation.


Locally Recurrent Malignant Neoplasm

description: The reemergence of a malignant neoplasm after a period of remission at the site of the original tumor or adjacent to it.


Pediatric Obesity

description: A condition in which a child's body mass index (BMI) falls at or above the 95th percentile based on the normative values for the age and sex of the reference population.


Cerebellar Glioblastoma

description: A glioblastoma that occurs in the cerebellum.


name: Acute Lymphoblastic Leukemia by ROSE Cluster

description: Unique gene expression-based patient cluster groups in high-risk B-precursor acute lymphoblastic leukemia determined by Recognition of Outliers by Sampling Ends (ROSE).


Bilateral Proliferative Retinopathy

description: Proliferative retinopathy occurring in both eyes.


Stage IVB Bone Cancer AJCC v7

description: Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N1: Regional lymph node metastasis.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


name: Cervix Intraepithelial Neoplasia Grade 3 AJCC v7

description: Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


name: Umbilical hernia without mention of obstruction or gangrene

description: The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the umbilicus, without mention of obstruction or necrosis of the herniated contents.


name: Locally Advanced Cervical Adenocarcinoma

description: A cervical adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Non-small cell carcinoma

description: A malignant epithelial neoplasm characterized by the absence of neoplastic small epithelial cells. A representative example is the lung non-small cell carcinoma.


Tumors Derived from Langerhans Cells

description: This category includes two main sub-groups, according to the degree of cytological atypia and clinical aggressiveness: Langerhans cell histiocytosis and Langerhans cell sarcoma. (WHO 2017)


Racial Melanosis

description: A benign conjunctival finding noted especially among darker pigmented individuals. While it is typically found perilimbally and bilaterally, it can also cover the conjunctivae extensively and may present asymmetrically. The flat, non-cystic pigmentation may increase in size with age. It is rare to have this finding evolve into conjunctival melanoma.


Broad Ligament Wolffian Tumor

description: An epithelial neoplasm of Wolffian (mesonephric) origin arising from the broad ligament. Most tumors behave in a benign fashion.


name: Pathologic Stage IIID Cutaneous Melanoma AJCC v8

description: Stage IIID includes: T4b, N3a/b/c, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Recurrent Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA

description: The reemergence of acute promyelocytic leukemia with t(15;17)(q24.1;q21.2); PML-RARA after a period of remission.


name: Stage M3 Childhood Ependymoma by Toronto Guidelines v2

description: Visible metastasis in spine or visible metastasis in cervicomedullary junction. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Midgut Neuroendocrine Tumor

description: A neuroendocrine tumor that arises from the jejunum, ileum, proximal colon, or appendix.


name: Idiopathic Dysplasia of Uncertain Significance

description: Prominent hematopoietic cell dysplasia with mild or absent cytopenia. It may progress to an overt myelodysplastic syndrome or other myeloid neoplasms such as acute myeloid leukemia, myeloproliferative neoplasm, or mast cell disorder.


name: Schizophrenia and other psychotic disorders

description: A category of psychiatric disorders characterized by the presence of psychotic symptoms such as delusions or hallucinations or negative symptoms such as affective flattening.


Tubal Hyperplasia

description: Benign proliferation of the fallopian tube epithelium.


name: acute combined systolic and diastolic congestive heart failure

description: Acute congestive heart failure due to reduced contractility of the left ventricle and which does not fill properly due to decreased compliance.


Abnormal Finding

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A decision that an observation or result is outside the parameters considered normal.


Trichilemmal carcinoma

description: A rare malignant tumor arising from the outer hair sheath and infundibulum on the face. It is considered the malignant counterpart of tricholemmoma. Complete surgical excision is required.


Stage IIIB Vulvar Cancer AJCC v7

description: Stage IIIB includes: (T1/T2, N2a/N2b, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N2a: Vulvar cancer with three or more lymph node metastases each measuring 5 mm or less.  N2b: Vulvar cancer with two or more lymph node metastases measuring 5 mm or greater.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Low Grade Gastric Intraepithelial Neoplasia

description: A gastric intraepithelial lesion characterized by the presence of neoplastic cells with mild cytologic atypia, mild architectural changes, and low number of mitotic figures.


name: Hodgkin's disease, lymphocytic depletion of lymph nodes of multiple sites

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Adenocarcinoma of the prostate stage III

description: Stage III includes: T3a-b, N0, M0, Any PSA, Any Gleason.  cT3a: Tumor with extracapsular extension (unilateral or bilateral).  pT3a: Tumor with extraprostatic extension or microscopic invasion of bladder neck.  T3b: Tumor invades seminal vesicle(s).  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Erosion lesion

description: An eating away or breakdown of any type of external or internal human tissue including but not limited to skin, teeth, mucosa, or somatic, which involves only the outer tissue layer. When tissue surrounds an implanted device, the tissue breakdown may result in migration and loss of the implant material and may result in further complications such as infection or abscess.


Hematoma

description: A localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel.


Unresectable Ampulla of Vater Carcinoma

description: Carcinoma that arises from the ampulla of Vater and is not amenable to surgical resection.


Carcinoma Metastatic to the Skin

description: A carcinoma that has spread to the skin from its original site of gowth.


Testicular Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the testis.  Representative examples include infection, torsion, and infarction.


name: Advanced Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Metastatic Melanoma

description: Metastatic melanoma that is resistant to treatment.


Stage IV Bone Sarcoma AJCC v7

description: Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Pancreatic Hepatoid Adenocarcinoma

description: A rare adenocarcinoma that arises from the pancreas.  It is characterized by marked hepatocellular differentiation.


Stage I Ampulla of Vater Cancer AJCC v8

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2, N0, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Acute Myeloid Leukemia with idic(X)(q13)

description: Acute myeloid leukemia associated with isodicentric chromosome Xq13 [idic(X)(q13)].


name: Non-Muscle Invasive Bladder Urothelial Carcinoma

description: An infiltrating urothelial carcinoma of the bladder that has not invaded into the bladder muscularis propria.


Non-Invasive Cribriform Carcinoma

description: A carcinoma characterized by the presence of a cribriform architectural pattern. There is no evidence of surrounding stromal invasion by the malignant cells.


name: Chronic Myelomonocytic Leukemia with Eosinophilia Associated with t(5;12)(q31;p12)

description: Chronic myelomonocytic leukemia characterized by the presence of eosinophilia, PDGFRB gene rearrangement, and t(5;12)(q31;p12).


Stage IVA Gallbladder Cancer AJCC v8

description: Stage IVA includes: T4, N0-1, M0. T4: Tumor invading the main portal vein or hepatic artery or invading two or more extrahepatic organs or structures. N0: No regional lymph node metastasis. N1: Metastases to one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Multiple congenital anomalies

description: The presence of multiple congenital malformations in a patient.


name: Mitochondrial Uncoupling Protein 2 Hyperinsulinism

description: Hyperinsulinism due to mutation(s) in the gene UCP2, encoding mitochondrial uncoupling protein 2, which plays a role in attenuating insulin secretion.


Supratentorial Ependymoma

description: A circumscribed ependymoma that arises from the supratentorial region of the brain. The diagnosis of supratentorial ependymoma should be made either when genetic analysis did not reveal a fusion gene involving ZFTA or YAP1 genes (not elsewhere classified -NEC) or when the genetic analysis was unsuccessful or not reported (not otherwise specified-NOS).


Pediatric Disorder

description: A non-neoplastic or neoplastic disorder which occurs during infancy, childhood, or adolescence.


name: Columnar Cell Change of the Breast with Atypia

description: A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini.  The acini are lined by one or two layers of columnar epithelial cells.  Cytologic atypia is present.


Foregut Neuroendocrine Tumor G2

description: A neuroendocrine tumor grade 2 that arises from the esophagus, stomach, or duodenum.


Asymptomatic Inflammatory Prostatitis

description: Inflammation of the prostate gland that is not associated with any symptoms. It is characterized by the presence of inflammatory cells in the prostatic fluid.


name: Complete unbalanced atrioventricular canal defect

description: Atrioventricular septal defect in which there is usually a single dominant ventricle and a hypoplastic ventricle.


Refractory Cytomegalovirus Infection

description: A cytomegalovirus infection that is resistant to treatment.


Liver Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the liver. The Ki-67 index is higher than 20%.


name: Recurrent Low Grade Endometrial Endometrioid Adenocarcinoma

description: The reemergence of endometrial low-grade endometrioid adenocarcinoma after a period of remission.


name: Deletion of Chromosome 22 Associated Meningioma

description: A meningioma that is associated with deletion of chromosome 22.  This abnormality is the most consistent cytogenetic finding that is detected in meningiomas.


Mouth cyst

description: A cystic lesion located in the oral cavity.


Stage IB Merkel Cell Carcinoma AJCC v7

description: Stage IB includes: T1, cN0, M0.  T1: Primary tumor equal or less than 2 cm in size.  cN0: No regional lymph node metastasis by clinical examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


name: Stage IV Ampulla of Vater Cancer AJCC v7

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis.  (from AJCC 7th Ed.)


Bone Schwannoma

description: A very rare schwannoma of the bone. It is often located in the mandible and is well circumscribed.


Esophageal dysplasia

description: A lesion that is characterized by architectural and cytologic abnormalities of the esophageal epithelium, and carries a predisposition for progression to invasive carcinoma.  Intraepithelial neoplasia (dysplasia) of the esophagus is graded as low or high grade.  In this two-tier system, severe dysplasia and carcinoma in situ are included under the rubric of high grade intraepithelial neoplasia and may have the same clinical implications.  (WHO, 2000)


Melanocytic matricoma

description: A rare benign pilar tumor with numerous intratumoral pigmented dendritic melanocytes. It typically affects elderly men. The most common location is the head and neck, followed by the trunk and the limbs. It manifests as a small, pigmented, purple or brownish-black papule or nodule. (WHO 2018)


Stage II Vaginal Cancer AJCC v6 and v7

description: Stage II includes: T2, N0, M0. T2: Tumor invades paravaginal tissues but not to pelvic wall.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Precursor T-lymphoblastic lymphoma/leukemia stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in a with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Radiating Chest Pain Along Left Lower Sternal Border

description: The location of the radiating chest pain is along the left lower sternal border.


Childhood Malignant Solid Neoplasm

description: A malignant solid neoplasm that occurs during childhood.


Infant Acute Undifferentiated Leukemia

description: An acute undifferentiated leukemia that occurs in infancy.


Developmental delay

description: Failure to meet, or late achievement of developmental milestones.


Acute gastritis

description: Acute inflammation of the stomach.


name: Stage IIIA Ampulla of Vater Cancer AJCC v8

description: Stage IIIA includes: (T1a, N1, M0); (T1b, N1, M0); (T2, N1, M0); (T3a, N1, M0); (T3b, N1, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N1: Metastasis to one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Sickle Beta 0 Thalassemia

description: A form of sickle cell thalassemia characterized by the absence of hemoglobin A. Patients usually have severe anemia identical to that seen in sickle cell disease.


Substance-Induced Sleep Disorder

description: A sleep disorder (insomnia, hypersomnia, or parasomnia) for which there is strong evidence that the disorder is etiologically linked to the direct physiological effects of a substance (i.e., a drug of abuse, a medication, or toxin exposure).


Unresectable Pancreatic Adenocarcinoma

description: Pancreatic adenocarcinoma that is not amenable to surgical resection.


name: Infant Acute Lymphoblastic Leukemia without KMT2A Rearrangement

description: An acute lymphoblastic leukemia without rearrangement of the KMT2A gene that occurs in infancy.


name: Myelodysplastic Syndrome, Not Otherwise Specified without Dysplasia

description: A premalignant hematologic condition characterized by cytopenia and absence of bone marrow dysplasia. There are less than 5% blasts in bone marrow and less than 2% blasts in peripheral blood.


Malposition of uterus

description: Orientation of the uterus in an unusual anatomic location or position.


Refractory acute myeloid leukemia

description: Acute myeloid leukemia that does not respond to treatment.


Stage III Fallopian Tube Cancer AJCC v8

description: Stage III includes: IIIA1: T1/2, N1, M0; IIIA2: T3a, N0/N1, M0; IIIB: T3b, N0/N1, M0; IIIC: T3c, N0/N1, M0. T1: Fallopian tube cancer with tumor limited to fallopian tube(s). T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. T3a: Fallopian tube cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. T3b: Fallopian tube cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. T3c: Fallopian tube cancer with macroscopic peritoneal metastasis beyond the pelvis more than 2 cm in greatest dimension with or without metastasis to the retroperitoneal lymph nodes (includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ). N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


name: Type II Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the coronary sinus.


Taste Disorders

description: Conditions characterized by an alteration in the ability to perceive taste.


name: Hepatocyte Nuclear Factor 4-Alpha Hyperinsulinism

description: Hyperinsulinism due to mutation(s) in the gene HNF4A, encoding the transcription factor hepatocyte nuclear factor 4-alpha. This condition may progress to diabetes later in life.


Cystine urolithiasis

description: Urolithiasis in which the composition of the stones is predominantly cystine.


name: Renal Pelvis and Ureter Cancer by AJCC v8 Stage

description: A term that refers to the staging of renal pelvis and ureter cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to renal pelvis and ureter urothelial (transitional cell) carcinoma, including histologic variants micropapillary and nested subtypes. It does not apply to renal cell carcinomas (are staged according to the classification for kidney), renal medullary carcinomas (are staged according to the classification for kidney), collecting duct carcinomas (are staged according to the classification for kidney),  lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and mesenchymal tumors (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs). (from AJCC 8th Ed.)


Megacystis - Megaureter

description: A condition characterized by a large capacity, thin-walled bladder and megaureter(s).


Condyloma Acuminatum with Dysplasia

description: Condyloma acuminatum that is associated with the presence of dysplastic epithelial changes.


Adenoma, Trabecular

description: A benign epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern.


Recurrent Adult Brain Neoplasm

description: The reemergence of brain neoplasm in adulthood after a period of remission.


Low Grade Mucinous Carcinoma Peritonei

description: A low-grade mucinous adenocarcinoma that has spread to the peritoneum.


Stage 0is Urethral Cancer AJCC v8

description: Stage 0is includes: Tis, N0, M0. Tis: For male penile urethra and female urethra: Carcinoma in situ. For prostatic urethra: Carcinoma in situ involving the prostatic urethra or periurethral or prostatic ducts without stromal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage I Ureter Cancer AJCC v7

description: Stage I includes: T1, N0, M0.  T1: Tumor invades subepithelial connective tissue. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Adenocarcinoma in villous adenoma

description: A non-invasive or invasive adenocarcinoma arising from a villous adenoma.


name: Advanced Anal Canal Squamous Cell Carcinoma

description: Anal canal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IB Osteosarcoma AJCC v7

description: Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


name: Paratesticular Clear Cell Adenocarcinoma

description: An exceedingly rare adenocarcinoma that arises from the paratesticular structures. It is characterized by the presence of columnar, hobnail, and polygonal cells with clear cytoplasm.


Acquired Cataract

description: Cataract that results from the aging process, an injury, or as a manifestation of a systemic disorder.


Stage IIIC1 Cervical Cancer FIGO 2018

description: Cervical carcinoma with pelvic lymph node metastasis only. (FIGO 2018)


name: Recurrent Small Cell Neuroendocrine Carcinoma

description: The reemergence of small cell neuroendocrine carcinoma after a period of remission.


name: Invasive Plasmacytoid Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by the presence of malignant cells with plasmacytoid features.


Stage IIA Gastric Cancer AJCC v7

description: Stage IIA includes: (T3, N0, M0); (T2, N1, M0); (T1, N2, M0). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


name: Locally Advanced Adenoid Cystic Carcinoma

description: Adenoid cystic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Ampulla of Vater Hepatoid Adenocarcinoma

description: A very rare adenocarcinoma that arises from the ampulla of Vater.  It is usually of the intestinal type and is characterized by the presence of malignant polygonal cells with abundant eosinophilic cytoplasm resembling hepatocytes.


Stage IA Bone Sarcoma AJCC v7

description: Stage IA includes: T1, N0, M0, G1, G2, GX.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


name: Locally Advanced Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Bladder Endometrioid Adenocarcinoma

description: A rare bladder adenocarcinoma with the histologic characteristics of endometrioid adenocarcinoma of the endometrium.


Lymphoma stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Metastatic Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that has spread from its original site of growth to another anatomic site.


Appendix Tubular Carcinoid

description: A neuroendocrine tumor that arises from the appendix.  It does not show the morphologic characteristics of typical carcinoid tumors (neoplastic cells forming solid nests). In contrast, the tumor cells form small discrete tubules.


name: Merkel Cell Carcinoma by AJCC v8 Pathologic Stage

description: A term that refers to the pathologic staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v8 classification system.


Smoldering Systemic Mastocytosis

description: Slowly progressive systemic mastocytosis with uncertain prognosis. It is characterized by organomegaly and absence of aggressive disease.


Fibrolipoma

description: A benign well-circumscribed tumor composed of mature adipocytes, characterized by areas of abundant fibrous tissue.


Stage IIA Testicular Cancer AJCC v8

description: Stage IIA includes: (Any pT/TX, N1, M0, S0); (Any pT/TX, N1, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Childhood Benign Skin Melanocytic Nevus

description: A circumscribed proliferation of melanocytes in the skin that occurs during childhood. It is characterized by the absence of atypical or malignant cytological features, and absence of invasive features or metastatic potential.


name: Adult Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for adult Hodgkin lymphoma based on the Ann Arbor classification criteria.


Stage IVA Cervical Cancer AJCC v9

description: Stage IVA includes: T4, Any N, M0. T4: Tumor has involved (biopsy-proven) the mucosa of the bladder or rectum, or has spread to adjacent organs. M0: No distant metastasis. (from AJCC 9th Ed.)


Placental site nodule

description: A non-neoplastic trophoblastic disorder characterized by the presence of remnants of intermediate trophoblasts in the uterine cavity and infrequently the fallopian tube from a previous pregnancy.


Congenital anomaly of eyelid

description: The abnormal formation of the eyelid that is present at the time of birth.


name: Prostate Adenocarcinoma with Neuroendocrine Differentiation

description: An invasive prostate adenocarcinoma characterized by the presence of malignant cells that exhibit neuroendocrine differentiation.


Psychological Dependence

description: A behavioral pattern characterized by a craving for the mood-altering effects of a drug and an overwhelming preoccupation with obtaining and using the drug.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Children's Oncology Group (COG) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the Toronto childhood cancer staging guidelines v2, Children's Oncology Group (COG) protocol. It is based on findings at surgery for patients who have not received chemotherapy prior to surgery. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Congenital postural scoliosis

description: Abnormal sideways curvature of the spine that is present at birth.


Rhabdomyolysis Related to COVID-19

description: Rhabdomyolysis in a patient with probable or confirmed acute COVID-19.


Cellular Blue Nevus

description: A blue nevus characterized by a multinodular cellular infiltrate with a dumb-bell architecture occupying the reticular dermis. The cellular infiltrate often extends into the subcutaneous tissue. The cellular infiltrate is composed of spindle-shaped melanocytes with pale cytoplasm alternating with bundles of pigmented spindle-shaped melanocytes. In occasional cases an increased mitotic activity, focal necrosis, and nuclear pleomorphism may be seen. Such cases with atypical features may have an uncertain malignant potential.


Metastatic Carcinoma in the Peritoneum

description: A carcinoma that has spread to the peritoneum from an adjacent or distal anatomic site.


name: Clinical Stage IV Retinoblastoma AJCC v8

description: Stage IV includes: Any cT, Any N, cM1 or pM1, Any H. cM1: Distant metastasis without microscopic confirmation. pM1: Distant metastasis with microscopic confirmation. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


name: Refractory Rare Malignant Solid Neoplasm

description: A rare malignant solid neoplasm that is resistant to treatment.


name: Stage I Renal Pelvis and Ureter Cancer AJCC v7

description: Stage I includes: T1, N0, M0.  T1: Tumor invades subepithelial connective tissue. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Recurrent Endometrial Transitional Cell Carcinoma

description: The reemergence of endometrial transitional cell carcinoma after a period of remission.


Refractory Low Grade Glioma

description: Low grade glioma that is resistant to treatment.


Oxyntic Gland Adenoma

description: A benign epithelial neoplasm composed of columnar cells with differentiation to chief cells, parietal cells, or both, with a high rate of progression to adenocarcinoma (submucosal invasion). (WHO 2019)


name: Stage IIB Digestive System Neuroendocrine Tumor AJCC v7

description: Stage IIB includes: T3, N0, M0.  T3: Stomach: tumor penetrates subserosa; jejunum/ileum: tumor invades through the muscularis propria into subserosal tissue without penetration of overlying serosa or invades into non-peritonealized tissues; ampulla/duodenum: tumor invades pancreas or retroperitoneum or into non-peritonealized tissues; colon or rectum: tumor invades through the muscularis propria into the subserosa, or into non-peritonealized pericolic or perirectal tissues. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Non-Obstructed Non-Refluxing Megaureter

description: A megaureter in which there is no obstruction at the ureterovesical junction and no vesicoureteral reflux.


name: Hodgkin's disease nodular sclerosis stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Hepatic Pain

description: A painful sensation in the liver.


Resectable Melanoma

description: Melanoma that is amenable to surgical resection.


name: Endometrial Endometrioid Adenocarcinoma with an Undifferentiated Carcinomatous Component

description: A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of a component with undifferentiated malignant cells.


name: Stage III Gastric Neuroendocrine Tumor AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N0, M0); (T4, N1, M0). T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. T2: Tumor invading the muscularis propria or is greater than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Lugano Classification Stage I Childhood Hodgkin Lymphoma AJCC v8

description: Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


name: Myeloproliferative Neoplasm, BCR-ABL1 Negative

description: A myeloproliferative neoplasm characterized by the absence of Philadelphia chromosome and BCR-ABL1 fusion gene expression. This group includes polycythemia vera, essential thrombocythemia, and primary myelofibrosis.


Stage IB2 Cervical Cancer

description: Stage IB2 includes: T1b2, N0, M0.  T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: High Grade Esophageal Glandular Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal glandular epithelium.


Passive-Aggressive Personality Disorder

description: A disorder characterized by a pattern of indirect expression of hostility, including negativistic attitudes and passive resistance to demands for adequate performance in social and occupational situations.


Refractory Sarcoma

description: A sarcoma that does not respond to treatment.


Esophageal mucositis

description: An inflammatory process affecting the mucous membrane of the esophagus.


Transferase Deficiency Galactosemia

description: A disorder characterized by the body's inability to metabolize galactose. This type of galactosemia is caused by germline mutations in the GALT gene which leads to the inhibition in the activity of the enzyme galactose-1-phosphate uridyl transferase.


Radiating Chest Pain in Back

description: The location of the radiating chest pain is in the back.


name: Refractory Langerhans Cell Histiocytosis

description: Langerhans cell histiocytosis that does not respond to treatment.


name: Refractory Large Cell Neuroendocrine Carcinoma

description: Large cell neuroendocrine carcinoma that is resistant to treatment.


name: Mast Cell Leukemia with an Associated Myeloid Neoplasm

description: Mast cell leukemia associated with another clonal non-mast cell myeloid neoplasm (e.g., myelodysplastic syndrome, myeloproliferative neoplasm, and acute myeloid leukemia).


Stage IIB Prostate Cancer AJCC v8

description: Stage IIB includes: T1-2, N0, M0, PSA less than 20, Grade Group 2. T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. (AJCC 8th ed.)


Ocular Graft Versus Host Disease

description: Graft versus host disease occurring in the eye.


Liver Neuroendocrine Neoplasm

description: An extremely rare neoplasm with neuroendocrine differentiation that arises from the liver. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


Stage IB Uterine Corpus Cancer AJCC v7

description: Stage IB includes: T1b, N0, M0.  T1b: Tumor invades one-half or more of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Pancreatobiliary Carcinoma

description: A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater.


Refractory Acute Bilineal Leukemia

description: Acute bilineal leukemia that is resistant to treatment.


Refractory Endometrial Carcinoma

description: Endometrial carcinoma that is resistant to treatment


Brain Damage, Chronic

description: Encephalopathy that is persistent or long-standing in nature.


Disorder by Site

description: A term that refers to the classification of a disorder according to the anatomic site that is involved in the pathologic process.


Jejunal fistula

description: An abnormal communication between the jejunum and another organ or cavity.


name: Locally Advanced Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: Extrapulmonary large cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Symmetric Chest Appearance

description: Inspection of the region of the anterior surface of the chest and epigastrium reveals an approximate correspondence of form and constituent configuration on opposite sides of a vertical central dividing line.


Esophageal Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Childhood Fibrillary Astrocytoma

description: A fibrillary astrocytoma that occurs during childhood.


name: Cervical Florid Reactive Lymphoid Hyperplasia

description: A dense, superficial benign lymphoid cell proliferation in the cervix. It almost always occurs in premenopausal women. It is composed of a mixture of large and small lymphocytes including immunoblasts. Plasma cells and neutrophils are also present. Immunohistochemical studies reveal a mixture of B and T lymphocytes, and polytypic plasma cells.


Lentiginous Melanocytic Nevus

description: A nevus characterized by an intraepidermal proliferation of nested melanocytes along the basal epidermis.


Metastatic malignant neoplasm to ureter

description: A malignant neoplasm that has spread to the ureter from another anatomic site.


name: Lugano Classification Stage IE Hodgkin Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Resectable Dedifferentiated Liposarcoma

description: Dedifferentiated liposarcoma that is amenable to surgical resection.


Refractory Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that is resistant to treatment.


name: Venous Thrombosis Related to Vascular Access Complication

description: The formation of a thrombus in the vein as a direct result of an activity associated with vascular access.


Adult Epithelioid Hemangioendothelioma

description: An epithelioid hemangioendothelioma that occurs during adulthood.


Radial scar

description: A benign breast lesion characterized by the presence of fibrosis with stellate appearance in the parenchyma.  The lesions are often multiple and bilateral.  Grossly, the lesions are irregular and firm and resemble carcinoma.  Microscopically, the stellate lesions are composed of dense, hyalinized collagen.  Entrapped in the collagen are tubules.  There is no evidence of cytologic atypia.


Cranial Nerve Injuries

description: Injury to, or disease of, the cranial nerve


name: Human Papillomavirus-Related Vaginal Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the vagina and is caused by human papillomavirus infection.


Non-ischemic Stroke

description: Any stroke that is not related to an obstructed blood vessel.


name: Recurrent Malignant Supratentorial Neoplasm

description: The reemergence of a malignant supratentorial neoplasm after a period of remission.


Delusional disorder, grandiose type

description: A subtype of delusional disorder characterized by the central delusional theme that the individual has special worth, power, knowledge, or a special relationship to a famous person or deity.


Miniature Adult Form of AHC

description: An autosomal recessive or sporadic form of adrenal hypoplasia congenita frequently associated with central nervous system anomalies including anencephaly and pituitary defects. Histologically the adrenal gland is distinguished by the absence of fetal adrenal cortex and the presence of a small amount of normal, permanent adult adrenal cortex.


Congenital Coronary Artery Abnormality

description: A congenital condition referring to defects of the course and structure of the coronary arteries.


Adult Benign Cerebellar Neoplasm

description: A benign neoplasm of the cerebellum occurring in adults.


Episodic Ataxia Type 2

description: An autosomal dominant condition caused by mutation(s) in the CACNA1A gene, encoding voltage-dependent P/Q-type calcium channel subunit alpha-1A. It is characterized by paroxysms of vertigo, visual disturbance, dysarthria, and ataxia.


Stage IB Bone Cancer AJCC v8

description: Stage IB includes: (T2, N0, M0, G1 or GX); (T3, N0, M0, G1 or GX). T2: Tumor measuring more than 8 cm in greatest dimension. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Well differentiated, low grade. (AJCC 8th ed.)


Bone Marrow Suppression

description: A condition in which the production of red blood cells, white blood cells, and/or platelets by bone marrow stem cells is inhibited, usually as a side effect of treatment with various anti-cancer agents, radiation, or tumor development within the bone marrow.


Metastatic basal cell carcinoma

description: A carcinoma that arises from the basal cells and has metastasized to another anatomic site.


Stage III Cervical Cancer AJCC v9

description: Stage III includes: T3, N0, M0. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: High Grade Conjunctival Melanocytic Intraepithelial Lesion

description: Conjunctival melanocytic intraepithelial lesion characterized by the presence of moderate to severe atypia.


Agenesis

description: A congenital abnormality resulting in the absence of an anatomical structure.


Stage I Cervical Cancer FIGO 2018

description: The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded). (FIGO 2018)


name: Grade II Glandular Intraepithelial Neoplasia


name: Recurrent Juvenile Myelomonocytic Leukemia

description: The reemergence of juvenile myelomonocytic leukemia after a period of remission.


description: An epithelioid hemangioendothelioma that occurs during childhood.


Locally Advanced Osteosarcoma

description: Osteosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Deformity

description: An anatomic abnormality that is either present at birth or appears later in life.


Cytomegaloviral gastritis

description: Inflammation of stomach that is associated with cytomegalovirus.


Methotrexate-Associated Lymphoma

description: A non-Hodgkin or Hodgkin lymphoma that develops in patients who are immunosuppressed with methotrexate.


name: T Acute Lymphoblastic Leukemia with TAL1 Rearrangement

description: T acute lymphoblastic leukemia characterized by the presence of TAL1 gene rearrangement.


name: Systemic lupus erythematosus, childhood onset

description: Systemic lupus erythematosus (SLE) diagnosed in individuals under the age of eighteen. Children frequently have multi-organ involvement and acute disease onset. Symptoms include fever, arthritis, skin lesions, anemia, and fatigue.


Benign neoplasm of female breast

description: A neoplasm that arises from the breast in females and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Early T-precursor lymphoblastic leukemia/lymphoma

description: T lymphoblastic leukemia/lymphoma in which the blasts have unique immunophenotypic and genetic characteristics suggesting only limited early T-cell differentiation.


Posterior Fossa Neoplasm

description: A neoplasm that arises from the posterior cranial fossa. Examples include meningiomas and medulloblastomas.


Recurrent Atypical Meningioma

description: The reemergence of atypical meningioma after a period of remission.


Hutch diverticulum

description: A congenital out pouching of the bladder involving the ureteral hiatus.


Obesity-Associated Insulin Resistance

description: Insulin resistance associated with obesity, which may be attributed in part to impaired insulin signaling in target tissues, or impaired insulin-stimulated glucose transport due to reduced expression of the glucose transporter protein 4.


Childhood Non-Ossifying Fibroma

description: A non-ossifying fibroma that occurs during childhood.


name: Clinical Stage IIC Cutaneous Melanoma AJCC v8

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Lymphoma, EBV-associated

description: Lymphoma that is caused by Epstein-Barr virus infection.


name: Stage I Anal Canal Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


name: T Acute Lymphoblastic Leukemia with LMO2 Rearrangement

description: T acute lymphoblastic leukemia characterized by the presence of LMO2 gene rearrangement.


Cutaneous Malignant Melanoma 2

description: An autosomal dominant genetic disorder caused by mutations in the CDKN2A gene, encoding cyclin-dependent kinase inhibitor 2A. The condition is characterized by cutaneous malignant melanoma associated with this genetic alteration.


Stage IVA Appendix Carcinoma AJCC v8

description: Stage IVA includes: (Any T, N0, M1a); (Any T, Any N, M1b, G1). N0: No regional lymph node metastasis. M1a: Intraperitoneal acellular mucin, without identifiable tumor cells in the disseminated peritoneal mucinous deposits. M1b: Intraperitoneal metastasis only, including peritoneal mucinous deposits containing tumor cells. G1: Well differentiated. (AJCC 8th ed.)


Chest Pain in Lower Sternum

description: The location of the chest pain is in the lower portion of the sternum.


name: Follicle Stimulating Hormone Receptor Deficiency

description: Reduced or absent function of the receptor for follicle stimulating hormone associated with a mutation in the FSHR gene.


Adult L2 Acute Lymphoblastic Leukemia

description: L2 acute lymphoblastic leukemia that occurs during adulthood.


name: Central Nervous System SMARCB1/INI1-Deficient Tumor

description: A group of SMARCB1/INI1 deficient tumors that arise from the central nervous system. It includes highly aggressive and slow-growing tumors.


name: Clinical Stage 0 Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Old Burn Scar-Related Cutaneous Melanoma

description: A cutaneous melanoma that arises in an old burn scar tissue.


Reactive Vascular Proliferation

description: A non-neoplastic proliferation of vessels in reaction to a process.


name: Recurrent Platinum-Resistant Fallopian Tube Carcinoma

description: The reemergence of platinum-resistant fallopian tube carcinoma after a period of remission.


Stage IV Vulvar Cancer AJCC v6

description: Stage IV includes: IVA (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4, Any N, M0); IVB (Any T, Any N, M1).  T4: Tumor invades any of the following: upper urethra bladder mucosa, rectal mucosa, or is fixed to the pubic bone.  N2: Bilateral regional lymph node metastasis.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 6th ed.)


Bladder Flat Urothelial Carcinoma

description: An in situ or invasive urothelial carcinoma that arises from the bladder wall and does not grow toward the hollow part of the bladder.


Intracranial Myeloid Sarcoma

description: A myeloid sarcoma that affects the meninges or the cerebral hemispheres.


name: High Grade Cervical Intraepithelial Neoplasia

description: Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of moderate or severe dysplastic changes.


Stage IIIA Vulvar Cancer AJCC v8

description: Stage IIIA includes: T1-T2, N1, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N1: Regional lymph node metastasis with one or two lymph node metastases each less than 5 mm, or one lymph node metastasis equal to 5 mm. M0: No distant metastasis. (AJCC 8th Ed.)


Fibrosarcoma non-metastatic

description: Fibrosarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


Cutaneous Neurocristic Hamartoma

description: A rare dermal and subcutaneous lesion that results from the aberrant development of neural crest-derived melanocytes.  It affects the head and neck with a predilection for the scalp.  It presents as a slowly enlarging multinodular plaque.  Morphologically is characterized by the presence of melanocytes and structures with schwannian differentiation in the dermis and subcutaneous tissue.


Anorectal infection

description: An infectious process affecting the anal area and the rectum.


Thrombocytopenic Disorder

description: A disorder of platelets characterized by a finding of low platelet concentrations (thrombocytopenia) typically below 50,000 platelets per microliter of blood.


name: Unspecified idiopathic peripheral neuropathy

description: Neuropathy, the cause of which is not known.


name: Oligometastatic Malignant Solid Neoplasm

description: A malignant solid neoplasm that has metastasized to a limited number of sites— existing in a state intermediate between localized disease and widespread metastatic disease.


name: Persistent Oligoarticular Juvenile Idiopathic Arthritis

description: Oligoarticular juvenile idiopathic arthritis that never involves more than four separate joints after six months.


Locally Advanced Prostate Carcinoma

description: A prostatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Cervical Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that arises from the cervix. This category includes neuroendocrine tumor grade 1, neuroendocrine tumor grade 2, and neuroendocrine carcinoma (small cell and large cell neuroendocrine carcinoma).


Childhood Neuroendocrine Tumor

description: A neuroendocrine tumor that occurs during childhood.


name: Locally Advanced Non-Muscle Invasive Bladder Carcinoma

description: Non-muscle invasive bladder carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IA Uterine Corpus Cancer AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Uterine corpus carcinoma or carcinosarcoma with tumor limited to the endometrium or invading less than half the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Pediatric Viral Infection

description: A viral infection that occurs during infancy, childhood or adolescence.


name: Immune Checkpoint Inhibitor-related Myocarditis

description: Myocarditis associated with the therapeutic use of an immune checkpoint inhibitor.


name: Meningeal Melanocytoma of Intermediate Grade

description: A circumscribed meningeal melanocytic neoplasm with bland histological features and increased mitotic activity or invasion of the central nervous system.


Pressing Pain

description: A sensation of discomfort or distress from excess weight or pressure on a specific anatomical location.


name: Fetus Small for Gestational Age with Abdominal Circumference Less than Tenth Percentile

description: A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and whose abdominal circumference falls below the tenth percentile.


name: Refractory Abdominal Neuroendocrine Neoplasm

description: An abdominal neuroendocrine neoplasm that does not respond to treatment.


name: Vaginal Large Cell Neuroendocrine Carcinoma

description: A rare, aggressive neuroendocrine carcinoma that arises from the vagina and is characterized by the presence of malignant cells with abundant cytoplasm, large nuclei, and prominent nucleoli.


name: Recurrent EBV-Related Lymphoproliferative Disease with Primary Immunodeficiency

description: The reemergence of EBV-associated lymphoproliferative disease with primary immunodeficiency after a period of remission.


name: Retinoblastoma by AJCC v8 Pathologic Stage

description: A term that refers to the pathologic staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition.


name: Diffuse Midline Glioma with EZHIP Overexpression

description: A diffuse midline glioma, H3 K27-altered, characterized by the presence of EZHIP overexpression.


Latent Infection

description: A period in which the infection is present in the host without producing overt symptoms.  (from Online Medical Dictionary)


name: Testicular Sclerosing Sertoli Cell Tumor

description: A rare testicular Sertoli cell tumor characterized by the presence of neoplastic tubules that are surrounded by a dense fibrotic stroma.


Recurrent Carcinoma

description: The reemergence of a carcinoma after a period of remission.


Stage IVA Uterine Corpus Cancer AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Uterine corpus carcinoma or carcinosarcoma with tumor invading the bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (from AJCC 8th Ed.)


Arbovirus hemorrhagic fever

description: A group of viral illnesses that are vectored by arthropods, and that are characterized by increased susceptibility to bleeding diatheses.


Ovulatory Pain

description: Painful sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle.


Locally Advanced Cutaneous Melanoma

description: Cutaneous melanoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Malignant Intracranial Neoplasm

description: A malignant neoplasm involving the intracranial space.


name: Cutaneous Acute Graft versus Host Disease

description: Skin manifestations of acute graft versus host disease, which typically presents as an erythematous maculopapular rash involving the face, ears, palms, and soles that may spread to the trunk and evolve to erythroderma.


name: Chronic Active EBV Infection of T-and NK-Cell Type, Systemic Form

description: An EBV-positive T-cell/NK-cell lymphoproliferative disorder characterized by repeated infectious mononucleosis-like symptoms, a very high titer of anti-EBV antibodies, and high levels of Epstein-Barr virus nucleic acids. Patients often develop progressive cellular and humoral immunodeficiency with pancytopenia and hypogammaglobulinemia.


name: Deep Venous Thrombosis Related to COVID-19

description: Deep vein thrombosis in a patient with probable or confirmed acute COVID-19.


name: Clinical Stage IA Cutaneous Melanoma AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Breast Neurofibroma

description: A neurofibroma that arises from the breast.


name: Advanced Cutaneous Melanoma of the Extremity

description: Cutaneous melanoma of the upper or lower extremity that has spread extensively to other anatomic sites or is no longer responding to treatment.


Radiation-induced fibrous mediastinitis

description: Fibrous mediastinitis arising due to radiation therapy.


name: Recurrent Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: The reemergence of extrapulmonary small cell neuroendocrine carcinoma after a period of remission.


Sessile Serrated Adenoma/Polyp

description: Polyps that arises from the large intestine and the appendix. They are characterized by the presence of serrated glands and the absence of generalized dysplasia.


name: Childhood Acute Myeloid Leukemia with Minimal Differentiation

description: An acute myeloid leukemia with minimal differentiation occurring in children.


name: Childhood Central Nervous System Neoplasm

description: A benign or malignant neoplasm of the brain, spinal cord, or meninges occurring in children.  Representative examples include posterior fossa astrocytoma, optic pathway glioma, medulloblastoma, ependymoma, and craniopharyngioma.


Primary malignant neoplasm

description: A malignant tumor at the original site of growth.


Recurrent Adnexal Carcinoma

description: The reemergence of adnexal carcinoma after a period of remission.


Metastatic Adnexal Carcinoma

description: Adnexal carcinoma that has spread from the original site of growth to other anatomic sites.


Stage IIB Osteosarcoma AJCC v7

description: Stage IIB includes: T2, N0, M0, G3, G4.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Fallopian Tube Metaplastic Papillary Lesion

description: A rare benign lesion that arises in the fallopian tubes of postpartum women. It is characterized by intratubal luminal papillary proliferation lined by columnar cells with abundant eosinophilic cytoplasm. Significant cytologic atypia and mitoses are absent. Mucinous and oncocytic metaplasia may be present.


Pancreatic Cancer by AJCC v8 Stage

description: A term that refers to the staging of exocrine pancreatic cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to pancreatic ductal adenocarcinoma, acinar cell carcinoma, intraductal papillary mucinous neoplasm with associated invasive carcinoma, intraductal tubulopapillary neoplasm with associated invasive carcinoma, colloid carcinoma, mucinous cystic neoplasm with associated invasive carcinoma, solid pseudopapillary neoplasm, large cell neuroendocrine carcinoma, small cell neuroendocrine carcinoma, and pancreatoblastoma. Well-differentiated neuroendocrine tumors are not staged using this staging system. (from AJCC 8th Ed.)


Primary osteosarcoma of bone

description: A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the bone. It usually involves the long bones and predominantly affects adolescents and young adults. Pain and a palpable mass are the most frequent clinical sign and symptom. It may spread to other anatomic sites, particularly the lungs.


name: FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting 5% or less solid non-glandular, non-squamous growth.


Chlamydia psittaci infection

description: A bacterial infection caused by Chlamydophila psittaci. Humans are infected by handling sick birds. The Chlamydiae cause respiratory infection manifests with fever, malaise, cough, dyspnea, sore throat, photophobia and headaches.


Clinical Test Result

description: The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition.


Stage IVB Cervical Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (including peritoneal spread or involvement of the supraclavicular, mediastinal, or distant lymph nodes; lung; liver; or bone). (from AJCC 8th Ed.)


Advanced Neuroendocrine Tumor

description: A neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Gastric Carcinoma

description: Gastric carcinoma that does not respond to treatment.


Solid pseudopapillary neoplasm

description: A low-grade malignant neoplasm that arises from the exocrine pancreas. Rare cases arising from ectopic pancreatic tissue in the ovary have also been described. It is characterized by the presence of uniform cells that form solid and pseudopapillary patterns, cystic changes, and hemorrhage. It usually presents as an encapsulated, solitary, and lobulated mass. It occurs predominantly in young women. Complete removal of the tumor is curative in the majority of cases.


IOL dislocation

description: Displacement of the intraocular lens from the visual axis.


name: Low-CSD Melanoma, Superficial Spreading Melanoma Subtype

description: A cutaneous melanoma that develops on sun exposed sites with low cumulative sun damage (CSD). It is characterized by a prominent junctional and intraepidermal component with intraepidermal proliferation of individual atypical melanocytes and formation of nests of atypical melanocytes along the dermal-epidermal junction. The dermal component is composed of atypical melanocytes that fail to mature. The atypical melanocytes have large nuclei, prominent nucleoli, and eosinophilic or lightly pigmented cytoplasm. It is the most common melanoma subtype in the Western world.


Stage IIA1 Cervical Cancer FIGO 2018

description: Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement, less than 4 cm in greatest dimension. (FIGO 2018)


Refractory Giant Cell Glioblastoma

description: Giant cell glioblastoma that is resistant to treatment.


Genitourinary System Carcinoma

description: A carcinoma arising from the genitourinary system. Representative examples include kidney carcinoma, bladder carcinoma, prostate carcinoma, endometrial carcinoma, cervical carcinoma, and ovarian carcinoma.


Anti-D Hemolytic Disease of the Newborn

description: A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of antibodies from a mother to the child via the placenta against the D antigen, the most common Rhesus factor.


Non-Neoplastic Thoracic Disorder

description: A non-neoplastic disorder that affects the thorax and/or the organs of the thoracic cavity.  Representative examples include pleural infection, mediastinitis, pneumonia, and chronic obstructive pulmonary disease.


name: Regional Urothelial Carcinoma of the Renal Pelvis and Ureter

description: Urothelial carcinoma of the renal pelvis or ureter that has spread to adjacent tissues and/or regional lymph nodes but not to distant anatomic sites.


Sarcoma of the Extremity

description: A sarcoma that arises from the soft tissues or bones of the upper or lower extremity.


Fetal Hypoxia

description: Hypoxia in utero, caused by conditions such as inadequate placental function (often abruptio placentae), preeclamptic toxicity, prolapse of the umbilical cord, or complications from anesthetic administration.


Stoma Site Infection

description: An infectious process affecting a surgically created opening in the surface of the body.


Recurrent Urinary System Carcinoma

description: Reemergence of a urinary system carcinoma after a period of remission.


Severe Mosquito Bite Allergy

description: An EBV-positive NK-cell lymphoproliferative disorder characterized by high fever and intense local skin symptoms, including erythema, bullae, ulcers, skin necrosis, and deep scarring following mosquito bites. Patients have NK-cell lymphocytosis in the peripheral blood and an increased risk of developing hemophagocytic syndrome and progressing into overt NK/T-cell lymphoma or aggressive NK-cell leukemia in the longstanding clinical course. (WHO 2017)


name: Classical Hodgkin lymphoma type posttransplant lymphoproliferative disorder

description: A lymphoproliferative disorder that fulfills the criteria for classic Hodgkin lymphoma and arises as a result of post-transplant immunosuppression therapy. It is most often seen in renal transplant patients.


Unresectable Bladder Adenocarcinoma

description: Bladder adenocarcinoma that is not amenable to surgical resection.


Stage I Gallbladder Cancer AJCC v7

description: Stage I includes: T1, N0, M0. T1: Tumor invades lamina propria or muscular layer.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Metastatic Digestive System Carcinoma

description: A carcinoma that arises from the gastrointestinal system and has metastasized to other anatomic sites.


Unresectable Meningioma

description: A meningioma that is not amenable to surgical resection.


Spinal Cord Hamartoma

description: A hamartoma that occurs in the spinal cord.


Musculoskeletal Pain

description: Pain that originates in the bones, muscles, tendons or ligaments.


Delusional disorder, unspecified type

description: A subtype of delusional disorder applied when the dominant delusional theme cannot be clearly determined.


name: Childhood Cancer Stage by Toronto Guidelines v2

description: A term that refers to the staging of childhood cancers following the rules of the Toronto guidelines v2, 2019. The guidelines were developed to address the lack of consistent information on childhood cancer staging in population registries and are not intended to replace staging systems in clinical use. They include a two-tiered approach that provides less detailed criteria for registries with limited resources and/or limited data access (Tier 1) and more detailed criteria for better-resourced registries (Tier 2). They apply to acute lymphoblastic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, neuroblastoma, renal malignant tumors except renal cell carcinoma, rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, malignant bone tumors, retinoblastoma, hepatoblastoma, testicular germ cell tumors, ovarian germ cell tumors, astrocytoma, medulloblastoma and ependymoma. The following changes were noted to the original classification (v1, 2014): a staging system was no longer considered appropriate for acute myeloid leukemia; all renal tumors, with the exception of renal cell carcinomas, should use the endorsed staging systems for Wilms tumor; staging systems for osteosarcoma and Ewing sarcoma were combined into a single recommendation for all malignant bone tumors; a staging system was endorsed for astrocytomas; the S category (serum tumor markers) was confirmed as an integral part of TNM staging for testicular cancer in Tier 2 recommendations; and PRETEXT number was added to Tier 2 recommendations for hepatoblastoma. (adapted from Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Lymphoma, AIDS-Related

description: An aggressive lymphoma that develops in HIV-positive patients.  There is a significant increase in the incidence of lymphomas associated with the AIDS epidemic.  These lymphomas are usually extranodal, most often express a B-cell phenotype and morphologically are classified as Burkitt, diffuse large B-cell, and Hodgkin lymphomas.  The prognosis is closely related to the severity of immunodeficiency.


name: Stage IV Appendix Neuroendocrine Tumor AJCC v7

description: Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


Cervical Neuroendocrine Tumor

description: A well-differentiated neuroendocrine neoplasm that arises from the cervix. It may be classified as G1 (low grade) or G2 (intermediate grade) neuroendocrine tumor.


name: Gastric Antrum Carcinoma In Situ AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial tumor without invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Incontinence

description: Involuntary passage of stool or urine from the body.


Locally Advanced Urothelial Carcinoma

description: A urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Urothelial Carcinoma, High Grade

description: Urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


Resectable Malignant Solid Neoplasm

description: Malignant solid neoplasm that is amenable to surgical resection.


Congenital Vena Cava Abnormality

description: An abnormality of the superior or inferior vena cava that is present at birth. Representative examples include persistent left superior vena cava, absence of infrarenal inferior vena cava, or absence of the entire inferior vena cava.


Post-Treatment Lyme Disease Syndrome

description: A constellation of symptoms lasting months to years reported by some Lyme disease patients who had undergone previous antibiotic therapy.


name: Childhood Langerhans Cell Histiocytosis with Risk Organ Involvement

description: Langerhans cell histiocytosis that occurs during childhood and involves the bone marrow, spleen, liver, or lung.


Prostate Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the prostate gland.  Representative examples include acute and chronic prostatitis.


Stage IB Pancreatic Cancer AJCC v8

description: Stage IB includes: T2, N0, M0. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metanephric stromal tumor

description: A rare benign renal neoplasm composed of moderately cellular spindle cells. It occurs mostly in infancy and childhood.


name: Recurrent Glioneuronal and Neuronal Tumors

description: The reemergence of glioneuronal and neuronal tumors after a period of remission.


Lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Esophageal Adenocarcinoma by AJCC v8 Pathologic Stage

description: A term that refers to the pathologic staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Scrotal hernia

description: The protrusion of abdominal cavity contents into the scrotal sac.


Integumentary System Signs and Symptoms

description: Patient complaints (symptoms), physical and/or laboratory findings related to the skin or integument.


Stage I Cervical Cancer AJCC v6 and v7

description: Stage I includes: I (T1, N0, M0); IA (T1a, N0, M0); IA1 (T1a1, N0, M0); IA2 (T1a2, N0, M0); IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1: Cervical carcinoma confined to uterus (extension to corpus should be disregarded). T1a: Invasive carcinoma diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. T1a1: Measured stromal invasion 3.0 mm or less in depth and 7.0 or less horizontal spread.  T1a2: Measured stromal invasion more than 3.0mm and not more than 5.0 mm with a horizontal spread 7.0mm or less. T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


COVID-19-Associated Encephalitis

description: Encephalitis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Childhood Neurofibroma

description: A neurofibroma that occurs during childhood.


name: Recurrent Malignant Nongerminomatous Germ Cell Tumor

description: The reemergence of a malignant nongerminomatous germ cell tumor after a period of remission.


name: Refractory Malignant Male Reproductive System Neoplasm

description: Malignant male reproductive system neoplasm that is resistant to treatment.


name: Ampulla of Vater Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region. The mitotic count is 2-20 per 10 HPF.


Advanced Lymphoma

description: Lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IIC Appendix Carcinoma AJCC v7

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades other organs or structures.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Chest Pain Along Left Anterior Axillary Line

description: The location of the chest pain is along the anterior axillary line on the left side.


Cervical Cancer by AJCC v9 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 9th edition. This staging system applies to carcinomas and carcinosarcomas. It does not apply to sarcomas, lymphomas, and melanomas. Sarcomas are staged according to the corpus uteri classification for sarcomas. Lymphomas are staged according to Hodgkin and non-Hodgkin lymphoma classification. Melanomas are not staged. (from AJCC 9th Ed.)


Childhood Schwannoma

description: A schwannoma that occurs during childhood.


name: Digestive System Neuroendocrine Tumor by AJCC v7 Stage

description: A term that refers to the staging of a digestive system neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system.


name: Childhood Hodgkin Lymphoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood Hodgkin lymphoma according to the Toronto childhood cancer staging guidelines v2. Staging is the same for both tiers (tier 1 and 2).


Rectal Pain

description: Pain in the rectal area.


Stage IIA1 Cervical Cancer AJCC v8

description: Stage IIA1 includes: T2a1, Any N, M0. T2a1: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Refractory Neuroendocrine Carcinoma

description: Neuroendocrine carcinoma that does not respond to treatment.


Cutaneous Melanoma by AJCC v8 Stage

description: A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system. This staging system does not apply to melanoma of the conjunctiva, melanoma of the uvea, mucosal melanoma arising in the head and neck, and mucosal melanoma of the urethra, vagina, rectum, and anus. (from AJCC 8th Ed.)


Dermal nerve sheath myxoma

description: A usually painless, slow growing benign tumor that most often arises from the extremities. It is characterized by the presence of abundant myxoid matrix and small epithelioid neoplastic Schwann cells.


Congenital Amegakaryocytosis

description: A rare disorder of infancy characterized by marked reduction or absence of megakaryocytes and thrombocytopenia.


Gastroesophageal Junction Carcinoma

description: A carcinoma that arises from the gastroesophageal junction. The vast majority of cases are adenocarcinomas. Rare cases are neuroendocrine carcinomas.


Cannabis dependence, episodic

description: Physical and psychological dependence on the drug cannabis, which is associated with a pattern of episodic use.


name: Metastatic Pancreatic Neuroendocrine Neoplasm

description: A pancreatic neuroendocrine neoplasm that has spread from its original site of growth to another anatomic site.


name: Myelodysplastic Chronic Myelomonocytic Leukemia

description: Chronic myelomonocytic leukemia characterized by the absence of a markedly elevated white blood cell count in the peripheral blood.


Poroid Hidradenoma

description: A poroma characterized by the presence of a single or several nodules of neoplastic cells forming solid and cystic areas in the dermis.


name: Non-Neoplastic Hematologic and Lymphocytic Disorder

description: A non-neoplastic disorder that arises from hematopoietic and lymphoid cells. It is characterized by the absence of a clonal cellular component. It rarely progresses to a malignant neoplasm.


Stage II Urethral Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: For male penile urethra and female urethra: Tumor invades any of the following: corpus spongiosum, periurethral muscle. For prostatic urethra: Tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Mesonephric Hyperplasia

description: A hyperplasia of the mesonephric cells.


name: Stage IB Ampulla of Vater Cancer AJCC v7

description: Stage IB includes: T2, N0, M0. T2: Tumor invades the duodenal wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Contact lens overwear syndrome (disorder)

description: Ocular pain which may be very intense, accompanied by corneal epithelium damage, conjunctival injection, lacrimation, blepharospasm, photophobia and hazy vision following corneal edema caused by overwear of contact lenses, principally the PMMA type.


neuroendocrine carcinoma of anal canal

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Acral Melanoma

description: A cutaneous melanoma that arises from the palms, soles, and nails.


name: Lugano Classification Limited Stage Adult Hodgkin Lymphoma AJCC v8

description: Limited stage adult Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Burning Chest Pain

description: The sensation of chest pain described as an intense discomfort, similar to that experience as a result of a thermal burn, distinct from sharp, stabbing or aching, often related to nerves; sometimes used to describe gastric or esophageal pain.


Unresectable Adenoid Cystic Carcinoma

description: Adenoid cystic carcinoma that is not amenable to surgical resection.


name: Bile Duct Mucinous Cystic Neoplasm, Low Grade

description: A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of mild atypia.


Childhood Gliosarcoma

description: A gliosarcoma that occurs during childhood.


name: Undifferentiated Carcinoma of Unknown Primary

description: An undifferentiated carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified.


Parapsoriasis lichenoides

description: A rare condition that stimulated chronic radiodermatitis.  It is considered a variant of mycosis fungoides.


name: acute undifferentiated leukemia in relapse

description: The reemergence of acute undifferentiated leukemia after a period of remission.


Sweat Gland Tubular Carcinoma

description: An aggressive adenocarcinoma that arises from the sweat glands. It usually presents as a firm, erythematous nodular lesion in the axilla. Morphologically, it is characterized by the presence of tubular structures and apocrine differentiation.


Stage III Vulvar Cancer AJCC v8

description: Stage III includes: T1-T2, N1-N2c, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N1: Regional lymph node metastasis with one or two lymph node metastases each less than 5 mm, or one lymph node metastasis equal to 5 mm. N2a: Three or more lymph node metastases each less than 5 mm. It includes micrometastasis, N2mi. N2b: Two or more lymph node metastases equal to 5 mm. N2c: Lymph node(s) metastasis with extranodal extension. M0: No distant metastasis. (AJCC 8th Ed.)


Parathyroid chief-cell hyperplasia

description: A hyperplasia of the chief cells of the parathyroid gland.


name: Recurrent Platinum-Sensitive Endometrial Carcinoma

description: The reemergence of platinum-sensitive endometrial carcinoma after a period of remission.


Lower Thigh Pain

description: A painful sensation in the distal thigh area.


Balloon cell nevus

description: An uncommon variant of melanocytic nevus. It presents as a small pigmented skin lesion. It is characterized by the presence of large melanocytes with clear, foamy or finely vacuolated cytoplasm. It may recur if it is not completely excised.


Sacral Myelocele

description: Herniation of spinal cord tissue and meninges through a defect in the sacral region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


Metastatic Neoplasm to the Bladder

description: The spread of a malignant neoplasm to the urinary bladder wall from an adjacent or distant anatomic site.


name: Stage y-III Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Incomplete excision of the tumor (gross or microscopic extension beyond the resection margins). Involved abdominal lymph nodes, including necrotic tumor or chemotherapy-induced changes. Tumor rupture before or intraoperatively. Tumor has penetrated the peritoneal surface. Tumor thrombi present at resection margins. Surgical biopsy prior to resection (does not include needle biopsy). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Lugano Classification Stage III Adult Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Acute Submassive Pulmonary Embolism

description: Acute pulmonary embolism with evidence of right ventricular dysfunction, but not associated with systemic hypotension.


name: Enterochromaffin-Like Cell Neuroendocrine Tumor G1

description: A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) arising from the gastrointestinal tract. It is characterized by the presence of enterochromaffin-like type granules in the neoplastic cells.


name: Invasive Conventional Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by the presence of malignant cells forming trabeculae, cords, sheets, and nests. Individual malignant cells are also present.


Stage IVB Gallbladder Cancer AJCC v7

description: Stage IVB includes: (Any T, N2, M0); (Any T, Any N, M1).  N2: Metastases to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes.  M0: No distant metastasis.  M1: Distant metastasis. (from AJCC 7th Ed.)


name: Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Metastatic Malignant Neoplasm in the Female Reproductive System

description: The spread of a malignant neoplasm to the female reproductive system from an adjacent or distant anatomic site.


name: IgM Monoclonal Gammopathy of Undetermined Significance, Not Otherwise Specified

description: A subtype of IgM monoclonal gammopathy of undetermined significance that includes cases associated with MYD88 mutation and cases associated with the presence of monoclonal B-lymphocytes without the presence of abnormal lymphoplasmacytic aggregates that are diagnostic of lymphoplasmacytic lymphoma or other small B-lymphocytic neoplasms.


Chronic Total Occlusion Vessel

description: A longstanding, complete blockage of a vessel. (ACC)


name: Malignant Germinative Follicular Epithelium Neoplasm

description: A malignant neoplasm that arises from germinative follicular epithelial cells.


name: Ampulla of Vater Cancer by AJCC v7 Stage

description: A term that refers to the staging of ampulla of Vater cancer according to the American Joint Committee on Cancer, 7th edition.


name: Recurrent Childhood Central Nervous System Neoplasm

description: The reemergence of central nervous system neoplasm in childhood after a period of remission.


COVID-19-Associated Stroke

description: Cerebrovascular accident caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Stage 0 Uterine Corpus Cancer

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis.  This staging applies to carcinomas and carcinosarcomas.  FIGO no longer includes Stage 0 (Tis). (AJCC 7th ed.)


name: Metastatic Digestive System Neuroendocrine Tumor G2

description: Digestive system neuroendocrine tumor G2 that has spread from its original site of growth to another anatomic site.


Stage IVB Cervical Cancer FIGO 2018

description: The cervical carcinoma has spread to distant organs. (FIGO 2018)


name: Cervical Papillary Squamous Cell Carcinoma

description: A human papillomavirus-related cervical squamous cell carcinoma characterized by the presence of papillary structures covered with epithelial cells which show features of cervical intraepithelial neoplasia. The malignant cellular component below the papillary structures is a squamous cell carcinoma.


name: Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: An undifferentiated high grade pleomorphic sarcoma that arises from the bone and occurs during childhood.


Refractory Primary Amyloidosis

description: Primary amyloidosis that does not respond to treatment.


Plasma Kallikrein Deficiency

description: A coagulation disorder characterized by the partial or complete absence of plasma-type kallikrein activity in the blood.


name: Childhood Refractory Malignant Solid Neoplasm

description: A childhood malignant solid neoplasm that does not respond to treatment.


Factor VII Inactivation

description: Presence of inactivating antibodies to factor VII in the blood.


Discoid Rash

description: A disc-shaped patch(es) of skin inflammation that is red, raised, and scaly; it typically develops on the face, scalp, and neck, and often leaves scars and dyspigmentation as a result of postinflammatory hyperpigmentation.


Adult Hodgkin Lymphoma

description: Hodgkin lymphoma occurring in adults.


Signet Ring Cell/Histiocytoid Carcinoma

description: A rare aggressive adnexal carcinoma preferentially affecting the eyelid and histopathologically resembling a metastatic lobular carcinoma of the breast and/or some adenocarcinomas arising in the gastrointestinal tract. (WHO 2018)


benign mature teratoma of pancreas

description: A mature teratoma that arises from the pancreas.


Early Prosthetic Valve Endocarditis

description: Prosthetic valve endocarditis that occurs days to weeks after surgery.


Advanced Pancreatic Carcinoma

description: Pancreatic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Meningohydroencephalocele

description: A congenital neural tube closure defect resulting in protrusion of the brain, the meninges, and the ventricular system through an opening in the skull, usually involving the squamous part of the occipital bone..


Skin squamous cell carcinoma metastatic

description: Squamous cell carcinoma of the skin which has spread to other anatomic sites.


Refractory Cervical Adenocarcinoma

description: Cervical adenocarcinoma that is resistant to treatment.


Chest Pain Along Midclavicular Line

description: The location of the chest pain is along an imaginary vertical line on the chest originating from the midpoint of a clavicle.


High Grade Osteosarcoma

description: An aggressive osteosarcoma with high-grade morphological features. This category includes high-grade surface osteosarcoma and conventional osteosarcoma.


name: Poorly Differentiated Prostate Adenocarcinoma

description: An invasive prostate adenocarcinoma characterized by the presence of poorly differentiated malignant cells.


Invasive Nested Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by a nested growth pattern.


Sickle cell-thalassemia disease

description: Hemolytic anemia, in which patients are heterozygous for both the sickle cell gene and a thalassemia gene.


Unfavorable Hodgkin Lymphoma

description: A Hodgkin lymphoma with unfavorable prognosis.


Primary Parathyroid Gland Hyperplasia

description: Parathyroid gland hyperplasia that occurs in the absence of physiological stimuli.


Stage IVB Osteosarcoma AJCC v7

description: Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N1: Regional lymph node metastasis.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Infarction of spinal cord

description: Ischemic necrosis of the spinal cord caused by occlusion of the arteries that supply blood to the spinal cord. Signs and symptoms include intermittent back pain, pain in the legs, paralysis, and incontinence.


Lower Ribs Pain

description: A sensation of discomfort emanating from the inferiormost (verterbrochondral or vertebral) ribs.


Hereditary Angioedema Types I and II

description: Autosomal dominant inherited disorders characterized by abnormalities of C1 inhibitor. Patients present with swelling of the skin, subcutaneous tissues, and mucosa sites. In type I hereditary angioedema, the plasma levels of C1 inhibitor are decreased. In type II hereditary angioedema, the C1 inhibitor is dysfunctional and its plasma levels may be normal or elevated.


Skin Granuloma

description: A granuloma located in the skin.


Uterine Corpus Cancer by AJCC v7 Stage

description: A term that refers to the staging of uterine corpus cancer (carcinoma or carcinosarcoma) according to the American Joint Committee on Cancer, 7th edition.