IL31_HUMAN Interleukin-31 (sprot)

An interleukin-31 that is encoded in the genome of human.


kidney leiomyosarcoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: An aggressive malignant smooth muscle neoplasm, arising from the kidney. It is characterized by a proliferation of neoplastic spindle cells.


name: KCNQ4_HUMAN Potassium voltage-gated channel subfamily KQT member 4 (sprot)

description: A voltage-gated potassium channel subunit KCNQ4 that is encoded in the genome of human.


name: KCNE4_HUMAN Potassium voltage-gated channel subfamily E member 4 (sprot)

description: A potassium voltage-gated channel subfamily E member 4 that is encoded in the genome of human.


name: ABL2_HUMAN Tyrosine-protein kinase ABL2 (sprot)

description: A tyrosine-protein kinase ABL2 that is encoded in the genome of human.


RADICICOL

An antifungal macrolactone antibiotic, obtained from Diheterospora chlamydosporia and Chaetomium chiversii that inhibits protein tyrosine kinase and heat shock protein 90 (Hsp90).


ivacaftor

An aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Used for the treatment of cystic fibrosis.


name: CD47_HUMAN Leukocyte surface antigen CD47 (sprot)

description: A CD47 molecule that is encoded in the genome of human.


phenylbutazone

A member of the class of  pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.


adenocarcinoma

description: A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma.


name: HS105_HUMAN Heat shock protein 105 kDa (sprot)

description: A heat shock protein 105 kDa that is encoded in the genome of human.


nelfinavir

An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.


thymoma

description: A neoplasm arising from the epithelial cells of the thymus. Although thymomas are usually encapsulated tumors, they may invade the capsule and infiltrate the surrounding tissues or even metastasize to distant anatomic sites. The following morphologic subtypes are currently recognized: type A, type B, type AB, metaplastic, micronodular, microscopic, and sclerosing thymoma. Thymomas type B are further subdivided into types B1, B2, and B3. Thymoma type B3 usually has the most aggressive clinical course.


dermatofibrosarcoma protuberans

description: Dermatofibrosarcoma protuberans (DFSP) is a rare infiltrating soft tissue sarcoma, generally of low grade malignancy, arising from the dermis of the skin and characteristically associated with a specific chromosomal translocation t(17;22).


cyclopentolate

A carboxylic ester resulting from the formal condensation of (1-hydroxycyclopentyl)(phenyl)acetic acid with N,N-dimethylethanolamine. A tertiary amine antimuscarinic with actions similar to atropine, it is used as its hydrochloride salt to produce mydriasis (excessive dilation of the pupil) and cycloplegia (paralysis  of the ciliary muscle of the eye) for opthalmic diagnostic procedures. It acts more quickly than atropine and has a shorter duration of action.


hyperopia, high

description: A severe form of hypermetropia with over +5.00 diopters.


retinol

A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraen-1-ol substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).


name: SH2D3_HUMAN SH2 domain-containing protein 3C (sprot)

description: An SH2 domain-containing protein 3C that is encoded in the genome of human.


CAV3_HUMAN Caveolin-3 (sprot)

A caveolin-3 that is encoded in the genome of human.


AMMONIUM SULFATE

An inorganic sulfate salt obtained by reaction of sulfuric acid with two equivalents of ammonia. A high-melting (decomposes above 280degreeC) white solid which is very soluble in water (70.6 g/100 g water at 0degreeC; 103.8 g/100 g water at 100degreeC), it is widely used as a fertilizer for alkaline soils.


name: MATN1_HUMAN Cartilage matrix protein (sprot)

description: A cartilage matrix protein that is encoded in the genome of human.


name: KAT1_HUMAN Kynurenine--oxoglutarate transaminase 1 (sprot)

description: A kynurenine--oxoglutarate transaminase 1 that is encoded in the genome of human.


name: myelodysplastic syndrome with single lineage dysplasia

description: A myelodysplastic syndrome characterized by dysplasia seen in at least 10% of the early cells of 1 cell type (either red blood cells, white blood cells, or megakaryocytes) in the bone marrow.


name: CLC4E_HUMAN C-type lectin domain family 4 member E (sprot)

description: A C-type lectin domain family 4 member E that is encoded in the genome of human.


gemifloxacin

A 1,4-dihydro-1,8-naphthyridine with a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a substituted pyrrolin-1-yl group at the 7-position.


name: BACD2_HUMAN BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (sprot)

description: A BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 that is encoded in the genome of human.


TRH

A tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence.


name: PSPB_HUMAN Pulmonary surfactant-associated protein B (sprot)

description: A pulmonary surfactant-associated protein B that is encoded in the genome of human.


name: IBP4_HUMAN Insulin-like growth factor-binding protein 4 (sprot)

description: An insulin-like growth factor-binding protein 4 that is encoded in the genome of human.


name: CSH1_HUMAN Chorionic somatomammotropin hormone 1 (sprot)

description: A chorionic somatomammotropin hormone 1 that is encoded in the genome of human.


name: CPSF3_HUMAN Cleavage and polyadenylation specificity factor subunit 3 (sprot)

description: A cleavage and polyadenylation specificity factor subunit 3 that is encoded in the genome of human.


name: SCAR3_HUMAN Scavenger receptor class A member 3 (sprot)

description: A scavenger receptor class A member 3 that is encoded in the genome of human.


severe cutaneous adverse reaction

description: A group of skin disorders including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed drug eruptions (GBFDE).


tylosin

A macrolide antibiotic that is tylonolide having mono- and diglycosyl moieties attached to two of its hydroxy groups. It is found naturally as a fermentation product of Streptomyces fradiae.


intestinal infectious disease

description: An infectious disease involving a pathogenic inflammatory response in the intestinal mucosa.


name: PLCB1_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (sprot)

description: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 that is encoded in the genome of human.


name: PP2AA_HUMAN Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (sprot)

description: A serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform that is encoded in the genome of human.


name: PSG1_HUMAN Pregnancy-specific beta-1-glycoprotein 1 (sprot)

description: A pregnancy-specific beta-1-glycoprotein 1 that is encoded in the genome of human.


name: SOX8_HUMAN Transcription factor SOX-8 (sprot)

description: A transcription factor SOX-8 that is encoded in the genome of human.


GLYCERYLPHOSPHATE

A glycerol monophosphate having the phosphate group at the 2-position.


name: ACHA_HUMAN Acetylcholine receptor subunit alpha (sprot)

description: An acetylcholine receptor subunit alpha that is encoded in the genome of human.


name: K2C8_HUMAN Keratin, type II cytoskeletal 8 (sprot)

description: A keratin, type II cytoskeletal 8 that is encoded in the genome of human.


name: PDLI7_HUMAN PDZ and LIM domain protein 7 (sprot)

description: A PDZ and LIM domain protein 7 that is encoded in the genome of human.


AREG_HUMAN Amphiregulin (sprot)

An amphiregulin that is encoded in the genome of human.


name: RAB7A_HUMAN Ras-related protein Rab-7a (sprot)

description: A Ras-related protein Rab-7a that is encoded in the genome of human.


calcipotriol

A seco-cholestane that is 26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene carrying additional hydroxy substituents at positions 1, 3 and 24. It is used (as its hydrate) in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients.


name: PSB8_HUMAN Proteasome subunit beta type-8 (sprot)

description: A proteasome subunit beta type-8 that is encoded in the genome of human.


rifamycin SV

A member of the class of rifamycins that exhibits antibiotic and antitubercular properties.


name: COMP_HUMAN Cartilage oligomeric matrix protein (sprot)

description: A cartilage oligomeric matrix protein that is encoded in the genome of human.


DNLI4_HUMAN DNA ligase 4 (sprot)

A DNA ligase 4 that is encoded in the genome of human.


name: FOXK2_HUMAN Forkhead box protein K2 (sprot)

description: A forkhead box protein K2 that is encoded in the genome of human.


cilostazol

A lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substituted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group.


name: PIGU_HUMAN Phosphatidylinositol glycan anchor biosynthesis class U protein (sprot)

description: A phosphatidylinositol glycan anchor biosynthesis class U protein that is encoded in the genome of human.


metastatic squamous cell carcinoma

description: A squamous cell carcinoma which has spread from its original site of growth to another anatomic site.


name: P3C2A_HUMAN Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (sprot)

description: A phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha that is encoded in the genome of human.


name: RHG35_HUMAN Rho GTPase-activating protein 35 (sprot)

description: A Rho GTPase-activating protein 35 that is encoded in the genome of human.


advanced heart failure

description: Patients with advanced heart failure have severe limitations, experiences symptoms even while at rest and are mostly bedbound patients.


name: TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6 (sprot)

description: A transient receptor potential cation channel subfamily V member 6 that is encoded in the genome of human.


cidofovir

Cytosine substituted at the 1 position by a 3-hydroxy-2-(phosphonomethoxy)propyl group (S configuration). A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.


name: SFTPD_HUMAN Pulmonary surfactant-associated protein D (sprot)

description: A pulmonary surfactant-associated protein D that is encoded in the genome of human.


soft tissue sarcoma

description: A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones.


name: MECOM_HUMAN Histone-lysine N-methyltransferase MECOM (sprot)

description: A histone-lysine N-methyltransferase MECOM that is encoded in the genome of human.


A1AT_HUMAN Alpha-1-antitrypsin (sprot)

An alpha-1-antitrypsin that is encoded in the genome of human.


name: THIOM_HUMAN Thioredoxin, mitochondrial (sprot)

description: A thioredoxin, mitochondrial that is encoded in the genome of human.


name: IQGA1_HUMAN Ras GTPase-activating-like protein IQGAP1 (sprot)

description: A Ras GTPase-activating-like protein IQGAP1 that is encoded in the genome of human.


name: LIN9_HUMAN Protein lin-9 homolog (sprot)

description: A lin-9 that is encoded in the genome of human.


name: FCG2C_HUMAN Low affinity immunoglobulin gamma Fc region receptor II-c (sprot)

description: A low affinity immunoglobulin gamma Fc region receptor II-c that is encoded in the genome of human.


name: KCNQ1_HUMAN Potassium voltage-gated channel subfamily KQT member 1 (sprot)

description: A voltage-gated potassium channel subunit KCNQ1 that is encoded in the genome of human.


name: HES6_HUMAN Transcription cofactor HES-6 (sprot)

description: A transcription cofactor HES-6 that is encoded in the genome of human.


name: ICOS_HUMAN Inducible T-cell costimulator (sprot)

description: An inducible T-cell costimulator that is encoded in the genome of human.


name: AMPL_HUMAN Cytosol aminopeptidase (sprot)

description: A cytosol aminopeptidase that is encoded in the genome of human.


name: ANM7_HUMAN Protein arginine N-methyltransferase 7 (sprot)

description: A protein arginine N-methyltransferase 7 that is encoded in the genome of human.


myelodysplastic syndrome

description: A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001)


ELAV2_HUMAN ELAV-like protein 2 (sprot)

An ELAV-like protein 2 that is encoded in the genome of human.


name: SYSC_HUMAN Serine--tRNA ligase, cytoplasmic (sprot)

description: A serine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


name: TRI62_HUMAN E3 ubiquitin-protein ligase TRIM62 (sprot)

description: An E3 ubiquitin-protein ligase TRIM62 that is encoded in the genome of human.


Horner syndrome

description: Horner's syndrome is a rare condition characterized by miosis (constriction of thepupil), ptosis (drooping of the upper eyelid), and anhidrosis (absence of sweating of the face). It iscaused by damage to the sympathetic nerves of the face. The underlying causes of Horner's syndrome vary greatly and may include a tumor, stroke, or other damage to a part of the brain called the brain stem ; injury to the carotid artery ;and trauma to the brachial plexus. In rare cases, Horner's syndrome is congenital (present from birth) and associated with a lack of pigmentation of the iris (colored part of the eye). Treatment of Horner's syndrome depends on the underlying cause.


name: CRYAA_HUMAN Alpha-crystallin A chain (sprot)

description: An alpha-crystallin A chain that is encoded in the genome of human.


KLK2_HUMAN Kallikrein-2 (sprot)

A kallikrein-2 that is encoded in the genome of human.


LATRUNCULIN B

A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica.


name: DUS3_HUMAN Dual specificity protein phosphatase 3 (sprot)

description: A dual specificity protein phosphatase 3 that is encoded in the genome of human.


EDN1_HUMAN Endothelin-1 (sprot)

An endothelin-1 that is encoded in the genome of human.


norethisterone

A 17beta-hydroxy steroid that is testosterone in which the hydrogen at position 17 is replaced by an ethynyl group and in which the methyl group attached to position 10 is replaced by hydrogen.


name: HAND2_HUMAN Heart- and neural crest derivatives-expressed protein 2 (sprot)

description: A heart- and neural crest derivatives-expressed protein 2 that is encoded in the genome of human.


name: DSRAD_HUMAN Double-stranded RNA-specific adenosine deaminase (sprot)

description: A double-stranded RNA-specific adenosine deaminase that is encoded in the genome of human.


name: MTA70_HUMAN N6-adenosine-methyltransferase catalytic subunit (sprot)

description: An N6-adenosine-methyltransferase catalytic subunit that is encoded in the genome of human.


LYSC_HUMAN Lysozyme C (sprot)

A lysozyme C that is encoded in the genome of human.


name: SMUG1_HUMAN Single-strand selective monofunctional uracil DNA glycosylase (sprot)

description: A single-strand selective monofunctional uracil DNA glycosylase that is encoded in the genome of human.


name: SMAD6_HUMAN Mothers against decapentaplegic homolog 6 (sprot)

description: A smad6 that is encoded in the genome of human.


name: GNA14_HUMAN Guanine nucleotide-binding protein subunit alpha-14 (sprot)

description: A guanine nucleotide-binding protein subunit alpha-14 that is encoded in the genome of human.


Hypochromia

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A qualitative impression that red blood cells have less color than normal when examined under a microscope, usually related to a reduced amount of hemoglobin in the red blood cells.


folinic acid

A formyltetrahydrofolic acid in which the formyl group is located at position 5.


name: ITM2A_HUMAN Integral membrane protein 2A (sprot)

description: An integral membrane protein 2A that is encoded in the genome of human.


name: IF4A3_HUMAN Eukaryotic initiation factor 4A-III (sprot)

description: A eukaryotic initiation factor 4A-III that is encoded in the genome of human.


name: RENT1_HUMAN Regulator of nonsense transcripts 1 (sprot)

description: A regulator of nonsense transcripts 1 that is encoded in the genome of human.


name: ABCA7_HUMAN Phospholipid-transporting ATPase ABCA7 (sprot)

description: A phospholipid-transporting ATPase ABCA7 that is encoded in the genome of human.


Ventricular hypertrophy

description: Enlargement of the cardiac ventricular muscle tissue with increase in the width of the wall of the ventricle and loss of elasticity. Ventricular hypertrophy is clinically differentiated into left and right ventricular hypertrophy.


name: respiratory syncytial virus infectious disease

description: Infection with the respiratory syncytial virus, an RNA virus of the genus Pneumovirus, in the family Paramyxoviridae, which is characterized by the formation of syncytia in tissue culture. It causes minor respiratory infection with rhinitis and cough in adults, but is capable of causing severe bronchitis and bronchopneumonia in young children.


An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.


name: ELOV7_HUMAN Very long chain fatty acid elongase 7 (sprot)

description: A very long chain fatty acid elongase 7 that is encoded in the genome of human.


TRYPTOPHOL

An indolyl alcohol that is ethanol substituted by a 1H-indol-3-yl group at position 2.


ciprofloxacin

A  quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.


hepatitis C virus infection

description: A viral infection caused by the hepatitis C virus.


name: PELI2_HUMAN E3 ubiquitin-protein ligase pellino homolog 2 (sprot)

description: An E3 ubiquitin-protein ligase pellino homolog 2 that is encoded in the genome of human.


name: CEP44_HUMAN Centrosomal protein of 44 kDa (sprot)

description: A centrosomal protein of 44 kDa that is encoded in the genome of human.


cefazolin

A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively.


sciatic neuropathy

description: Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)


A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.


name: KMT2C_HUMAN Histone-lysine N-methyltransferase 2C (sprot)

description: A histone-lysine N-methyltransferase 2C that is encoded in the genome of human.


name: SETD5_HUMAN Histone-lysine N-methyltransferase SETD5 (sprot)

description: A histone-lysine N-methyltransferase SETD5 that is encoded in the genome of human.


name: PCDGD_HUMAN Protocadherin gamma-B1 (sprot)

description: A protocadherin gamma-B1 that is encoded in the genome of human.


autonomic neuropathy

description: An inherited or acquired peripheral neuropathy affecting the autonomic nervous system. It results in disruption of the involuntary body functions. Inherited causes include Fabry disease and porphyrias. Acquired causes include diabetes, uremia, hepatic disorders, vitamin deficiencies, toxins, and drug toxicities.


name: CSRN1_HUMAN Cysteine/serine-rich nuclear protein 1 (sprot)

description: An Axin-1 up-regulated gene 1 protein that is encoded in the genome of human.


name: MMP14_HUMAN Matrix metalloproteinase-14 (sprot)

description: A matrix metalloproteinase-14 that is encoded in the genome of human.


name: ASF1A_HUMAN Histone chaperone ASF1A (sprot)

description: A histone chaperone ASF1A that is encoded in the genome of human.


name: T23O_HUMAN Tryptophan 2,3-dioxygenase (sprot)

description: A tryptophan 2,3-dioxygenase that is encoded in the genome of human.


name: CCND2_HUMAN G1/S-specific cyclin-D2 (sprot)

description: A G1/S-specific cyclin-D2 that is encoded in the genome of human.


TLR7_HUMAN Toll-like receptor 7 (sprot)

A Toll-like receptor 7 that is encoded in the genome of human.


name: CLPP_HUMAN ATP-dependent Clp protease proteolytic subunit, mitochondrial (sprot)

description: An ATP-dependent Clp protease proteolytic subunit, mitochondrial that is encoded in the genome of human.


name: UBP5_HUMAN Ubiquitin carboxyl-terminal hydrolase 5 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 5 that is encoded in the genome of human.


name: AMHR2_HUMAN Anti-Muellerian hormone type-2 receptor (sprot)

description: An anti-Muellerian hormone type-2 receptor that is encoded in the genome of human.


INDOLE-3-ACETIC ACID

A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group.


armodafinil

A 2-[(diphenylmethyl)sulfinyl]acetamide that has R configuration at the sulfur atom. Like its racemate, modafinil, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. Peak concentration in the blood later occurs later following administration than with modafinil, so it is thought that armodafinil may be more effective than modafinil in treating people with excessive daytime sleepiness.


bipolar I disorder

description: A bipolar disorder that is characterized by at least one manic or mixed episode.


name: IFM3_HUMAN Interferon-induced transmembrane protein 3 (sprot)

description: An interferon-induced transmembrane protein that is a translation product of the IFITM3 gene in human.


name: MCRS1_HUMAN Microspherule protein 1 (sprot)

description: A microspherule protein 1 that is encoded in the genome of human.


name: CHIP_HUMAN E3 ubiquitin-protein ligase CHIP (sprot)

description: An E3 ubiquitin-protein ligase CHIP that is encoded in the genome of human.


deferasirox

A member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions.


name: LEAP2_HUMAN Liver-expressed antimicrobial peptide 2 (sprot)

description: A liver-expressed antimicrobial peptide 2 that is encoded in the genome of human.


name: RUNX3_HUMAN Runt-related transcription factor 3 (sprot)

description: A runt-related transcription factor 3 that is encoded in the genome of human.


APOA2_HUMAN Apolipoprotein A-II (sprot)

An apolipoprotein A-II that is encoded in the genome of human.


A member of the class of diamino-1,3,5-triazines that is 1,3,5-triazine-2,4-diamine in which the amino groups at positions 2 and 4 are respectively carrying 2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl and 2-(propan-2-ylsulfonyl)phenyl substituents. It is a potent inhibitor of anaplastic lymphoma kinase (ALK), Ack and ROS1 activity (IC50 values are 3.5, 5.8 and 8.9 nM respectively) and exhibits anti-cancer properties.


name: TNK1_HUMAN Non-receptor tyrosine-protein kinase TNK1 (sprot)

description: A non-receptor tyrosine-protein kinase TNK1 that is encoded in the genome of human.


magnesium hydroxide

A magnesium hydroxide in which the magnesium atom is bound to two hydroxide groups.


name: CAHM3_HUMAN Calcium homeostasis modulator protein 3 (sprot)

description: A calcium homeostasis modulator protein 3 that is encoded in the genome of human.


PAPP1_HUMAN Pappalysin-1 (sprot)

A pappalysin-1 that is encoded in the genome of human.


name: DNJB1_HUMAN DnaJ homolog subfamily B member 1 (sprot)

description: A DnaJ homolog subfamily B member 1 that is encoded in the genome of human.


name: PRS4_HUMAN 26S proteasome regulatory subunit 4 (sprot)

description: A 26S proteasome regulatory subunit 4 that is encoded in the genome of human.


alfacalcidol

A member of the class of D3 vitamins that is calciol in which the hydrogen at the 1alpha position is replaced by a hydroxy group. It is an active metabolite of cholecalciferol, which performs important functions in regulation of the calcium balance and the bone metabolism.


imidapril

A member of the class of imidazolidines that is (4S)-1-methyl-2-oxoimidazolidine-4-carboxylic acid in which the hydrogen of the imidazolidine nitrogen has been substituted by (1S)-1-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}ethyl group. It is the prodrug for imidaprilat, an ACE inhibitor used for the treatment of chronic heart failure.


Splenomegaly

description: Abnormal increased size of the spleen.


isotretinoin

A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases.


Granuloma

description: A compact, organized collection of mature mononuclear phagocytes, which may be but is not necessarily accompanied by accessory features such as necrosis.


name: VAV3_HUMAN Guanine nucleotide exchange factor VAV3 (sprot)

description: A guanine nucleotide exchange factor VAV3 that is encoded in the genome of human.


phosphatidylcholine (20:2/20:4)

A phosphatidylcholine 40:6 in which the fatty acyl groups at positions 1 and 2 are specified as C20:2 and C20:4 respectively.


An oxysterol that is cholesterol which is substituted by a hydroxy group at position 24.


name: MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (sprot)

description: A mucosa-associated lymphoid tissue lymphoma translocation protein 1 that is encoded in the genome of human.


desloratadine

Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an  antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness.


chronic urticaria

description: An urticaria that is characterized by the presence of urticaria for a period exceeding 6 weeks, assuming symptoms for most days of the week.


name: AOFB_HUMAN Amine oxidase [flavin-containing] B (sprot)

description: An amine oxidase [flavin-containing] B that is encoded in the genome of human.


nitroxoline

A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5.


name: FKBP8_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP8 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP8 that is encoded in the genome of human.


VADIMEZAN

A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 5,6-dimethyl-9-oxoxanthen-4-yl group.


name: NSD1_HUMAN Histone-lysine N-methyltransferase, H3 lysine-36 specific (sprot)

description: A histone-lysine N-methyltransferase, H3 lysine-36 specific that is encoded in the genome of human.


name: RBP2_HUMAN E3 SUMO-protein ligase RanBP2 (sprot)

description: An E3 SUMO-protein ligase RanBP2 that is encoded in the genome of human.


name: TYRP2_HUMAN L-dopachrome tautomerase (sprot)

description: An L-dopachrome tautomerase that is encoded in the genome of human.


name: VGLL1_HUMAN Transcription cofactor vestigial-like protein 1 (sprot)

description: A transcription cofactor vestigial-like protein 1 that is encoded in the genome of human.


name: TEAD4_HUMAN Transcriptional enhancer factor TEF-3 (sprot)

description: A transcriptional enhancer factor TEF-3 that is encoded in the genome of human.


irritable bowel syndrome

description: Irritable bowel syndrome (IBS) is a chronic functional condition of the lower gastrointestinal (GI) tract characterized by abdominal pain or discomfort and disordered bowel habit (diarrhea, constipation, or fluctuation between the two).


irbesartan

A  biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.


pulmonary emphysema

description: A subcategory of chronic obstructive pulmonary disease (COPD). It occurs in people who smoke and suffer from chronic bronchitis. It is characterized by inflation of the alveoli, alveolar wall damage, and reduction in the number of alveoli, resulting in difficulty breathing.


barasertib

A dihydrogen phosphate prodrug of a pyrazoloquinazoline aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide(HQPA) and is converted rapidly to the active AZD1152-HQPA in plasma.


urticaria

description: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.


name: CHD3_HUMAN Chromodomain-helicase-DNA-binding protein 3 (sprot)

description: A chromodomain-helicase-DNA-binding protein 3 that is encoded in the genome of human.


name: BIP_HUMAN Endoplasmic reticulum chaperone BiP (sprot)

description: An endoplasmic reticulum chaperone BiP that is encoded in the genome of human.


name: RL11_HUMAN Large ribosomal subunit protein uL5 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL5 that is encoded in the genome of human.


name: LX15B_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX15B (sprot)

description: A polyunsaturated fatty acid lipoxygenase ALOX15B that is encoded in the genome of human.


name: S22A8_HUMAN Organic anion transporter 3 (sprot)

description: An organic anion transporter 3 that is encoded in the genome of human.


name: IOD1_HUMAN Type I iodothyronine deiodinase (sprot)

description: A type I iodothyronine deiodinase that is encoded in the genome of human.


name: HMMR_HUMAN Hyaluronan mediated motility receptor (sprot)

description: A hyaluronan mediated motility receptor that is encoded in the genome of human.


name: 8ODP_HUMAN Oxidized purine nucleoside triphosphate hydrolase (sprot)

description: An oxidized purine nucleoside triphosphate hydrolase that is encoded in the genome of human.


etomidate

The ethyl ester of 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid. It is an intravenous general anaesthetic with no analgesic activity.


diabetic retinopathy

description: A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness.


TANESPIMYCIN

A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects.


name: PGAM5_HUMAN Serine/threonine-protein phosphatase PGAM5, mitochondrial (sprot)

description: A serine/threonine-protein phosphatase PGAM5, mitochondrial that is encoded in the genome of human.


name: SND1_HUMAN Staphylococcal nuclease domain-containing protein 1 (sprot)

description: A staphylococcal nuclease domain-containing protein 1 that is encoded in the genome of human.


name: SKAP2_HUMAN Src kinase-associated phosphoprotein 2 (sprot)

description: A Src kinase-associated phosphoprotein 2 that is encoded in the genome of human.


name: LGUL_HUMAN Lactoylglutathione lyase (sprot)

description: A lactoylglutathione lyase that is encoded in the genome of human.


MDM4_HUMAN Protein Mdm4 (sprot)

A protein Mdm4 that is encoded in the genome of human.


name: BATF2_HUMAN Basic leucine zipper transcriptional factor ATF-like 2 (sprot)

description: A basic leucine zipper transcriptional factor ATF-like 2 that is encoded in the genome of human.


name: IBP1_HUMAN Insulin-like growth factor-binding protein 1 (sprot)

description: An insulin-like growth factor-binding protein 1 that is encoded in the genome of human.


type IV hypersensitivity disease

description: A disease that has its basis in the disruption of type IV hypersensitivity.


name: SETB2_HUMAN Histone-lysine N-methyltransferase SETDB2 (sprot)

description: A histone-lysine N-methyltransferase SETDB2 that is encoded in the genome of human.


restrictive cardiomyopathy

description: A type of heart disorder referring to the inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and looses its flexibility. Causes include replacement of the myocardium with scar tissue, abnormal cellular infiltration of the myocardium, or deposition of a substance (e.g., amyloid) in the myocardium.


clofibrate

The ethyl ester of clofibric acid.


atomoxetine

A  secondary amino compound having methyl and 3-(2-methylphenoxy)-3-phenylpropan-1-yl substituents.


autism

description: Persistent deficits in social interaction and communication and interaction as well as a markedly restricted repertoire of activity and interest as well as repetitive patterns of behavior.


name: NR5A2_HUMAN Nuclear receptor subfamily 5 group A member 2 (sprot)

description: A nuclear receptor subfamily 5 group A member 2 that is encoded in the genome of human.


name: GOT1A_HUMAN Vesicle transport protein GOT1A (sprot)

description: A vesicle transport protein GOT1A that is encoded in the genome of human.


bosutinib

An aminoquinoline that is 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline bearing additional cyano and methoxy substituents at positions 3 and 6 respectively.


CADH3_HUMAN Cadherin-3 (sprot)

A cadherin-3 that is encoded in the genome of human.


NANO1_HUMAN Nanos homolog 1 (sprot)

A nanos homolog 1 that is encoded in the genome of human.


UCN1_HUMAN Urocortin (sprot)

A urocortin that is encoded in the genome of human.


Chronic neutropenia

description: Neutropenia with an absolute neutrophil count (ANC) less than 1,500,000,000/L lasting for more than 3 months.


Werner syndrome

description: A rare inherited syndrome characterized by premature aging with onset in the third decade of life and with cardinal clinical features including bilateral cataracts, short stature, graying and thinning of scalp hair, characteristic skin disorders and premature onset of additional age-related disorders.


name: CSN1_HUMAN COP9 signalosome complex subunit 1 (sprot)

description: A COP9 signalosome complex subunit 1 that is encoded in the genome of human.


hemorrhagic disease

description: Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (blood coagulation disorders) or another abnormality causing a structural flaw in the blood vessels (hemostatic disorders).


polymyalgia rheumatica

description: A syndrome characterized by pain, stiffness, and tenderness of the proximal muscle groups including the shoulder, pelvic girdle and the neck. There is no muscle atrophy and muscle biopsies do not reveal pathologic changes. Additional signs and symptoms include low grade fever, fatigue and depression.


Leber hereditary optic neuropathy

description: Leber's hereditary optic neuropathy (LHON) is a mitochondrial neurodegenerative disease affecting the optic nerve and often characterized by sudden vision loss in young adult carriers.


name: LRIG1_HUMAN Leucine-rich repeats and immunoglobulin-like domains protein 1 (sprot)

description: A leucine-rich repeats and immunoglobulin-like domains protein 1 that is encoded in the genome of human.


name: MLH1_HUMAN DNA mismatch repair protein Mlh1 (sprot)

description: A DNA mismatch repair protein Mlh1 that is encoded in the genome of human.


name: SO4A1_HUMAN Solute carrier organic anion transporter family member 4A1 (sprot)

description: A solute carrier organic anion transporter family member 4A1 that is encoded in the genome of human.


name: K2C7_HUMAN Keratin, type II cytoskeletal 7 (sprot)

description: A keratin, type II cytoskeletal 7 that is encoded in the genome of human.


name: NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 that is encoded in the genome of human.


name: ADRM1_HUMAN Proteasomal ubiquitin receptor ADRM1 (sprot)

description: A proteasomal ubiquitin receptor ADRM1 that is encoded in the genome of human.


name: GPC5B_HUMAN G-protein coupled receptor family C group 5 member B (sprot)

description: A G-protein coupled receptor family C group 5 member B that is encoded in the genome of human.


name: DLG4_HUMAN Disks large homolog 4 (sprot)

description: A disks large homolog 4 that is encoded in the genome of human.


ITA1_HUMAN Integrin alpha-1 (sprot)

An integrin alpha-1 that is encoded in the genome of human.


name: CXL13_HUMAN C-X-C motif chemokine 13 (sprot)

description: A C-X-C motif chemokine 13 that is encoded in the genome of human.


name: DMRT1_HUMAN Doublesex- and mab-3-related transcription factor 1 (sprot)

description: A doublesex- and mab-3-related transcription factor 1 that is encoded in the genome of human.


name: ML12B_HUMAN Myosin regulatory light chain 12B (sprot)

description: A myosin regulatory light chain 12B that is encoded in the genome of human.


cantharidin

A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria.  Natural toxin inhibitor of protein phosphatases 1 and 2A.


name: HIPK2_HUMAN Homeodomain-interacting protein kinase 2 (sprot)

description: A homeodomain-interacting protein kinase 2 that is encoded in the genome of human.


sinapic acid

A monohydroxycinnamic acid that is cinnamic acid in which the phenyl hydrogens at positions 3, 4, and 5 are replaced by methoxy, hydroxy, and methoxy groups, respectively.


name: FGF11_HUMAN Fibroblast growth factor 11 (sprot)

description: A fibroblast growth factor 11 that is encoded in the genome of human.


DISOGENIN

A  sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone.


name: TNR8_HUMAN Tumor necrosis factor receptor superfamily member 8 (sprot)

description: A tumor necrosis factor receptor superfamily member 8 that is encoded in the genome of human.


name: NHRF1_HUMAN Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (sprot)

description: A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is encoded in the genome of human.


name: GAS1_HUMAN Growth arrest-specific protein 1 (sprot)

description: A growth arrest-specific protein 1 that is encoded in the genome of human.


alopecia

description: Hair loss usually from the scalp. It may result in bald spots or spread to the entire scalp or the entire epidermis. It may be androgenetic or caused by chemotherapeutic agents, compulsive hair pulling, autoimmune disorders or congenital conditions.


name: C560_HUMAN Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (sprot)

description: A succinate dehydrogenase cytochrome b560 subunit, mitochondrial that is encoded in the genome of human.


name: MSRE_HUMAN Macrophage scavenger receptor types I and II (sprot)

description: A macrophage scavenger receptor types I and II that is encoded in the genome of human.


endometrium adenocarcinoma

description: An adenocarcinoma arising from the uterine body cavity. This is the most frequent malignant tumor affecting the uterine body, and is linked to estrogen therapy. Most patients present with uterine bleeding and are over age 40 at the time of diagnosis. The prognosis depends on the stage of the tumor, the depth of the uterine wall invasion, and the histologic subtype. Endometrioid adenocarcinoma is the most frequently seen morphologic variant of endometrial adenocarcinoma.


MYF6_HUMAN Myogenic factor 6 (sprot)

A myogenic factor 6 that is encoded in the genome of human.


DINITROCHLOROBENZENE

A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.


name: RIPK3_HUMAN Receptor-interacting serine/threonine-protein kinase 3 (sprot)

description: A receptor-interacting serine/threonine-protein kinase 3 that is encoded in the genome of human.


fluocinolone acetonide

A fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatment of various skin disorders.


name: T2R13_HUMAN Taste receptor type 2 member 13 (sprot)

description: A taste receptor type 2 member 13 that is encoded in the genome of human.


name: CR3L4_HUMAN Cyclic AMP-responsive element-binding protein 3-like protein 4 (sprot)

description: A cyclic AMP-responsive element-binding protein 3-like protein 4 that is encoded in the genome of human.


MT1A_HUMAN Metallothionein-1A (sprot)

A metallothionein-1A that is encoded in the genome of human.


name: BARD1_HUMAN BRCA1-associated RING domain protein 1 (sprot)

description: A BRCA1-associated RING domain protein 1 that is encoded in the genome of human.


name: WDR26_HUMAN WD repeat-containing protein 26 (sprot)

description: A WD repeat-containing protein 26 that is encoded in the genome of human.


tromethamine

A primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 7--9; pKa = 8.3 at 20 degreeC; pKa = 7.82 at 37 degreeC.


name: PPA5_HUMAN Tartrate-resistant acid phosphatase type 5 (sprot)

description: A tartrate-resistant acid phosphatase type 5 that is encoded in the genome of human.


name: ANM3_HUMAN Protein arginine N-methyltransferase 3 (sprot)

description: A protein arginine N-methyltransferase 3 that is encoded in the genome of human.


muscular atrophy

description: The loss of muscle tissue due to inactivity or disease.


AQP5_HUMAN Aquaporin-5 (sprot)

An aquaporin-5 that is encoded in the genome of human.


name: CTDS2_HUMAN Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (sprot)

description: A carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 that is encoded in the genome of human.


name: MOT8_HUMAN Monocarboxylate transporter 8 (sprot)

description: A monocarboxylate transporter 8 that is encoded in the genome of human.


ISOFLAVONE

A simplest member of the class of isoflavones  that is 4H-chromen-4-one in which the hydrogen at position 3 is replaced by a phenyl group.


exemestane

A 17-oxo steroid that is androsta-1,4-diene-3,17-dione in which the hydrogens at position 6 are replaced by a double bond to a methylene group. A selective inhibitor of the aromatase (oestrogen synthase) system, it is used in the treatment of advanced breast cancer.


name: MCM2_HUMAN DNA replication licensing factor MCM2 (sprot)

description: A DNA replication licensing factor MCM2 that is encoded in the genome of human.


triclocarban

A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.


name: NMDZ1_HUMAN Glutamate receptor ionotropic, NMDA 1 (sprot)

description: A glutamate receptor ionotropic, NMDA 1 that is encoded in the genome of human.


hypertensive encephalopathy

description: Encephalopathy resulting from hypertension.


name: NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like (sprot)

description: An E3 ubiquitin-protein ligase NEDD4-like that is encoded in the genome of human.


name: ADCY5_HUMAN Adenylate cyclase type 5 (sprot)

description: An adenylate cyclase type 5 that is encoded in the genome of human.


name: TAL1_HUMAN T-cell acute lymphocytic leukemia protein 1 (sprot)

description: A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of human.


GLUC_HUMAN Pro-glucagon (sprot)

A pro-glucagon that is encoded in the genome of human.


arachnoiditis

description: Arachnoiditis (ARC) is a chronic inflammation of the arachnoid layer of the meninges, of which adhesive arachnoiditis is the most severe form, characterized by debilitating, intractable neurogenic back and limb pain and a range of other neurological problems.


Barrett adenocarcinoma

description: An adenocarcinoma arising from Barrett metaplastic epithelium in the esophagus. There is evidence supporting the idea that the Barrett adenocarcinomas develop through a stepwise progression through intestinal metaplastic epithelium to epithelial dysplasia to malignancy. Adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. In terms of grading, they are well or moderately differentiated adenocarcinomas. -- 2002


name: SYCP3_HUMAN Synaptonemal complex protein 3 (sprot)

description: A synaptonemal complex protein 3 that is encoded in the genome of human.


meralgia paresthetica

description: Meralgia paresthetica is a condition characterized by tingling, numbness and burning pain in the outer thigh. These symptoms may become worse after walking or standing. The condition generally only affects one side of the body, although both sides may be involved in up to 20% of cases. Meralgia paresthetica is caused by compression of the lateral femoral cutaneous nerve (a sensory nerve to the skin on the outer thigh). This may be associated with a variety of causes such as tight clothing, obesity, and/or pregnancy. Treatment is based on the signs and symptoms present in each person and may include medications to manage pain. In most cases, conservative treatment by wearing looser clothing and/or losing weight generally resolves symptoms.


polyp of large intestine

description: A polyp that involves the large intestine.


name: DGAT1_HUMAN Diacylglycerol O-acyltransferase 1 (sprot)

description: A diacylglycerol O-acyltransferase 1 that is encoded in the genome of human.


name: LMAN2_HUMAN Vesicular integral-membrane protein VIP36 (sprot)

description: A vesicular integral-membrane protein VIP36 that is encoded in the genome of human.


bufexamac

A hydroxamic acid derived from phenylacetamide in which the benzene moiety is substituted at C-4 by a butoxy group. It has anti-inflammatory, analgesic, and antipyretic properties.


name: FBLN3_HUMAN EGF-containing fibulin-like extracellular matrix protein 1 (sprot)

description: An EGF-containing fibulin-like extracellular matrix protein 1 that is encoded in the genome of human.


name: HLAB_HUMAN HLA class I histocompatibility antigen, B alpha chain (sprot)

description: An MHC class I histocompatibility antigen B alpha chain that is encoded in the genome of human.


HYPOCHLOROUS ACID

A chlorine oxoacid with formula HOCl; a weak, unstable acid, it is the active form of chlorine in water.


CLD4_HUMAN Claudin-4 (sprot)

A claudin-4 that is encoded in the genome of human.


Aortic dissection

description: Aortic dissection refers to a tear in the intimal layer of the aorta causing a separation between the intima and the medial layers of the aorta.


CLD22_HUMAN Claudin-22 (sprot)

A claudin-22 that is encoded in the genome of human.


eosinophilic meningitis

description: Meningitis in which eosinophils predominate in the cerebrospinal fluid.


entrectinib

A member of the class of indazoles that is 1H-indazole substituted by [4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzoyl]amino and 3,5-difluorobenzyl groups at positions 3 and 5, respectively. It is a potent inhibitor of TRKA, TRKB, TRKC, ROS1, and ALK (IC50 values of 0.1 to 1.7 nM), and used for the treatment of NTRK, ROS1 and ALK gene fusion-positive solid tumours.


CATZ_HUMAN Cathepsin Z (sprot)

A cathepsin Z that is encoded in the genome of human.


myotonic dystrophy type 1

description: Steinert disease, also known as myotonic dystrophy type 1, is a muscle disease characterized by myotonia and by multiorgan damage that combines various degrees of muscle weakness, arrhythmia and/or cardiac conduction disorders, cataract, endocrine damage, sleep disorders and baldness.


oxide

An oxide is a chemical compound of oxygen with other chemical elements.


name: SL9A6_HUMAN Sodium/hydrogen exchanger 6 (sprot)

description: A sodium/hydrogen exchanger 6 that is encoded in the genome of human.


name: B4GN2_HUMAN Beta-1,4 N-acetylgalactosaminyltransferase 2 (sprot)

description: A beta-1,4 N-acetylgalactosaminyltransferase 2 that is encoded in the genome of human.


ivermectin

A mixture consisting of >= 90% 22,23-dihydroavermectin B1a (R = Me) and <= 10% 22,23-dihydroavermectin B1b (R = H). A semi-synthetic derivative of abamectin, it is used as a broad-spectrum antiparasite medication, particularly against worms (except tapeworms), although it is also effective against most mites and some lice.


phosphatidylinositol (16:0/18:2)

A phosphatidylinositol 34:2 in which the acyl group at C-1 contains 16 carbons and no double bonds while that at C-2 contains 18 carbons and 2 double bonds


name: CNOT6_HUMAN CCR4-NOT transcription complex subunit 6 (sprot)

description: A CCR4-NOT transcription complex subunit 6 that is encoded in the genome of human.


name: RND3_HUMAN Rho-related GTP-binding protein RhoE (sprot)

description: A Rho-related GTP-binding protein RhoE that is encoded in the genome of human.


name: TBX21_HUMAN T-box transcription factor TBX21 (sprot)

description: A T-box transcription factor TBX21 that is encoded in the genome of human.


STAB1_HUMAN Stabilin-1 (sprot)

A stabilin-1 that is encoded in the genome of human.


name: MCAF1_HUMAN Activating transcription factor 7-interacting protein 1 (sprot)

description: An activating transcription factor 7-interacting protein 1 that is encoded in the genome of human.


name: ASCL1_HUMAN Achaete-scute homolog 1 (sprot)

description: An achaete-scute homolog 1 that is encoded in the genome of human.


thrombophlebitis

description: Inflammation of the veins associated with the presence of a thrombus.


glycogen

A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.


name: ASSY_HUMAN Argininosuccinate synthase (sprot)

description: An argininosuccinate synthase that is encoded in the genome of human.


MYOC_HUMAN Myocilin (sprot)

A myocilin that is encoded in the genome of human.


DUOX2_HUMAN Dual oxidase 2 (sprot)

A dual oxidase 2 that is encoded in the genome of human.


RUVB2_HUMAN RuvB-like 2 (sprot)

A RuvB-like 2 that is encoded in the genome of human.


name: MYB_HUMAN Transcriptional activator Myb (sprot)

description: A myb proto-oncogene protein that is encoded in the genome of human.


pancreatitis

description: Inflammation of the pancreas.


name: LYRM4_HUMAN LYR motif-containing protein 4 (sprot)

description: A LYR motif-containing protein 4 that is encoded in the genome of human.


CD48_HUMAN CD48 antigen (sprot)

A CD48 molecule that is encoded in the genome of human.


name: NELL1_HUMAN Protein kinase C-binding protein NELL1 (sprot)

description: A protein kinase C-binding protein NELL1 that is encoded in the genome of human.


Acute colitis

description: An acute and self-limited inflammatory disease of the large intestine (colon, cecum and rectum).


L-NNA

An L-arginine derivative that is L-arginine in which the terminal nitrogen of the guanidyl group is replaced by a nitro group.


CALX_HUMAN Calnexin (sprot)

A calnexin that is encoded in the genome of human.


immunodeficiency disease

description: Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.


L-lactic acid

An optically active form of lactic acid having (S)-configuration.


name: MOT2_HUMAN Monocarboxylate transporter 2 (sprot)

description: A monocarboxylate transporter 2 that is encoded in the genome of human.


BACE1_HUMAN Beta-secretase 1 (sprot)

A beta-secretase 1 that is encoded in the genome of human.


name: PREP_HUMAN Presequence protease, mitochondrial (sprot)

description: A presequence protease, mitochondrial that is encoded in the genome of human.


name: LEF1_HUMAN Lymphoid enhancer-binding factor 1 (sprot)

description: A lymphoid enhancer-binding factor 1 that is encoded in the genome of human.


name: ACOHC_HUMAN Cytoplasmic aconitate hydratase (sprot)

description: A cytoplasmic aconitate hydratase that is encoded in the genome of human.


name: IF2B2_HUMAN Insulin-like growth factor 2 mRNA-binding protein 2 (sprot)

description: An insulin-like growth factor 2 mRNA-binding protein 2 that is encoded in the genome of human.


name: IMP3_HUMAN U3 small nucleolar ribonucleoprotein protein IMP3 (sprot)

description: A U3 small nucleolar ribonucleoprotein protein IMP3 that is encoded in the genome of human.


name: RFC3_HUMAN Replication factor C subunit 3 (sprot)

description: A replication factor C subunit 3 that is encoded in the genome of human.


name: DENR_HUMAN Density-regulated protein (sprot)

description: A density-regulated protein that is encoded in the genome of human.


acalabrutinib

A member of the class of imidazopyrazines that is imidazo[1,5-a]pyrazine substituted by 4-(pyridin-2-ylcarbamoyl)phenyl, (2S)-1-(but-2-ynoyl)pyrrolidin-2-yl, and amino groups at positions 1, 3 and 8, respectively. It is an irreversible second-generation Bruton's tyrosine kinase (BTK) inhibitor that is approved by the FDA for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy.


name: TAU_HUMAN Microtubule-associated protein tau (sprot)

description: A microtubule-associated protein tau that is encoded in the genome of human.


name: MCTS1_HUMAN Malignant T-cell-amplified sequence 1 (sprot)

description: A malignant T cell-amplified sequence 1 that is encoded in the genome of human.


name: FZR1_HUMAN Fizzy-related protein homolog (sprot)

description: A fizzy-related protein that is encoded in the genome of human.


TEST_HUMAN Testisin (sprot)

A testisin that is encoded in the genome of human.


name: BCDO1_HUMAN Beta,beta-carotene 15,15'-dioxygenase (sprot)

description: A beta,beta-carotene 15,15'-dioxygenase that is encoded in the genome of human.


spinal cord neoplasm

description: A neoplasm (disease) that involves the spinal cord.


name: TGM2_HUMAN Protein-glutamine gamma-glutamyltransferase 2 (sprot)

description: A protein-glutamine gamma-glutamyltransferase 2 that is encoded in the genome of human.


paromomycin

An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.


glycyl-L-phenylalanine 2-naphthylamide

An N-(2-naphthyl)carboxamide obtained by formal condensation of the carboxy group of glycyl-L-phenylalanine with the amino group of 2-naphthylamine.


name: TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 (sprot)

description: A transient receptor potential cation channel TRPA1 that is encoded in the genome of human.


pergolide

A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.


GINSENOSIDE RE

A ginsenoside found in Panax ginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.


bucladesine

A 3',5'-cyclic purine nucleotide that is the 2'-butanoate ester and 6-N-butanoyl derivative of 3',5'-cyclic AMP.


name: TNNI1_HUMAN Troponin I, slow skeletal muscle (sprot)

description: A troponin I, slow skeletal muscle that is encoded in the genome of human.


name: CX6A2_HUMAN Cytochrome c oxidase subunit 6A2, mitochondrial (sprot)

description: A cytochrome c oxidase subunit 6A2, mitochondrial that is encoded in the genome of human.


roxadustat

An N-acylglycine resulting from the formal condensation of the amino group of glycine with the carboxy group of 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid. It is an inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PH).


ESCULIN

A hydroxycoumarin that is the 6-O-beta-D-glucoside of esculetin.


name: HBP1_HUMAN HMG box-containing protein 1 (sprot)

description: An HMG box-containing protein 1 that is encoded in the genome of human.


name: MYCN_HUMAN N-myc proto-oncogene protein (sprot)

description: An N-myc proto-oncogene protein that is encoded in the genome of human.


name: AZI2_HUMAN 5-azacytidine-induced protein 2 (sprot)

description: A 5-azacytidine-induced protein 2 that is encoded in the genome of human.


severe combined immunodeficiency

description: Severe combined immunodeficiency (SCID) comprises a group of rare monogenic primary immunodeficiency disorders characterized by a lack of functional peripheral T lymphocytes resulting in early-onset severe respiratory infections and failure to thrive. They are classified according to immunological phenotype into SCID with absence of T cells but presence of B cells (T-B+ SCID) or SCID with absence of both (T-B- SCID). Both of these groups include several forms, with or without natural killer (NK) cells.


name: CELF2_HUMAN CUGBP Elav-like family member 2 (sprot)

description: A CUGBP Elav-like family member 2 that is encoded in the genome of human.


name: PREX2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (sprot)

description: A phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein that is encoded in the genome of human.


name: C1QR1_HUMAN Complement component C1q receptor (sprot)

description: A complement component C1q receptor that is encoded in the genome of human.


name: CCL21_HUMAN C-C motif chemokine 21 (sprot)

description: A C-C motif chemokine 21 that is encoded in the genome of human.


angioimmunoblastic T-cell lymphoma

description: A mature T-cell non-Hodgkin lymphoma, characterized by systemic disease and a polymorphous infiltrate involving lymph nodes and extranodal sites. The clinical course is typically aggressive.


albendazole

A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a propylsulfanyl group at position 5. It is commonly used in the treatment of parasitic worm infestations.


Hepatomegaly

description: Abnormally increased size of the liver.


phloroglucinol

A benzenetriol with hydroxy groups at position 1, 3 and 5.


putrescine

A four-carbon alkane-alpha,omega-diamine. It is obtained by the breakdown of amino acids and is responsible for the foul odour of putrefying flesh.


non-histaminic angioedema

description: Angioedema is characterized by the occurrence of transitory and recurrent subcutaneous and/or submucosal edemas resulting in swelling and/or abdominal pain.


vatalanib

A member of the class of phthalazines that is phthalazine in which the hydrogens at positions 1 and 4have been replaced by a p-chlorophenylamino group and a pyridin-4-ylmethyl group, respectively. It is a multi-targeted tyrosine kinase inhibitor for all isoforms of VEGFR, PDGFR and c-Kit.


name: FUT4_HUMAN Alpha-(1,3)-fucosyltransferase 4 (sprot)

description: An alpha-(1,3)-fucosyltransferase 4 that is encoded in the genome of human.


name: MYO1E_HUMAN Unconventional myosin-Ie (sprot)

description: A myosin-Ie that is encoded in the genome of human.


name: NF2IP_HUMAN NFATC2-interacting protein (sprot)

description: An NFATC2-interacting protein that is encoded in the genome of human.


name: CDC5L_HUMAN Cell division cycle 5-like protein (sprot)

description: A cell division cycle 5-like protein that is encoded in the genome of human.


name: DCAM_HUMAN S-adenosylmethionine decarboxylase proenzyme (sprot)

description: A SAM decarboxylase proenzyme that is encoded in the genome of human.


name: NGLY1_HUMAN Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (sprot)

description: A peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase that is encoded in the genome of human.


name: NR0B1_HUMAN Nuclear receptor subfamily 0 group B member 1 (sprot)

description: A nuclear receptor subfamily 0 group B member 1 that is encoded in the genome of human.


name: SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (sprot)

description: A proto-oncogene tyrosine-protein kinase Src that is encoded in the genome of human.


enoxacin

A 1,8-naphthyridine derivative that is 1,4-dihydro-1,8-naphthyridine with an ethyl group at the 1 position, a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a piperazin-1-yl group at the 7 position. An antibacterial, it is used in the treatment of urinary-tract infections and gonorrhoea.


name: FOXC2_HUMAN Forkhead box protein C2 (sprot)

description: A forkhead box protein C2 that is encoded in the genome of human.


name: UBA1_HUMAN Ubiquitin-like modifier-activating enzyme 1 (sprot)

description: A ubiquitin-like modifier-activating enzyme 1 that is encoded in the genome of human.


name: DDX17_HUMAN Probable ATP-dependent RNA helicase DDX17 (sprot)

description: A probable ATP-dependent RNA helicase DDX17 that is encoded in the genome of human.


A glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups.


name: GRID2_HUMAN Glutamate receptor ionotropic, delta-2 (sprot)

description: A glutamate receptor ionotropic, delta-2 that is encoded in the genome of human.


paliperidone

A member of the class of pyridopyrimidines that is 9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.


PSN1_HUMAN Presenilin-1 (sprot)

A presenilin-1 that is encoded in the genome of human.


CATK_HUMAN Cathepsin K (sprot)

A cathepsin K that is encoded in the genome of human.


name: 5HT6R_HUMAN 5-hydroxytryptamine receptor 6 (sprot)

description: A 5-hydroxytryptamine receptor 6 that is encoded in the genome of human.


CALCR_HUMAN Calcitonin receptor (sprot)

A calcitonin receptor that is encoded in the genome of human.


SBSN_HUMAN Suprabasin (sprot)

A suprabasin that is encoded in the genome of human.


RETNB_HUMAN Resistin-like beta (sprot)

A resistin-like beta that is encoded in the genome of human.


dolutegravir

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1.


NLRC5_HUMAN Protein NLRC5 (sprot)

A protein NLRC5 that is encoded in the genome of human.


name: CKS1_HUMAN Cyclin-dependent kinases regulatory subunit 1 (sprot)

description: A cyclin-dependent kinases regulatory subunit 1 that is encoded in the genome of human.


phosphatidylcholine (18:1/22:6)

A phosphatidylcholine 40:7 in which the fatty acyl groups at positions 1 and 2 are specified as C18:1 and C22:6 respectively.


name: PER3_HUMAN Period circadian protein homolog 3 (sprot)

description: A period circadian protein homolog 3 that is encoded in the genome of human.


name: KLF15_HUMAN Krueppel-like factor 15 (sprot)

description: A krueppel-like factor 15 that is encoded in the genome of human.


name: GRIN2_HUMAN G protein-regulated inducer of neurite outgrowth 2 (sprot)

description: A G protein-regulated inducer of neurite outgrowth 2 that is encoded in the genome of human.


DFB4A_HUMAN Defensin beta 4A (sprot)

A defensin beta 4A that is encoded in the genome of human.


lung disorder

description: A disease involving the lung.


galantamine

A benzazepine alkaloid isolated from certain species of daffodils.


brain neoplasm

description: A neoplasm (disease) that involves the brain.


name: QCR1_HUMAN Cytochrome b-c1 complex subunit 1, mitochondrial (sprot)

description: A cytochrome b-c1 complex subunit 1, mitochondrial that is encoded in the genome of human.


name: PTPRA_HUMAN Receptor-type tyrosine-protein phosphatase alpha (sprot)

description: A receptor-type tyrosine-protein phosphatase alpha that is encoded in the genome of human.


esophagitis

description: An acute or chronic inflammatory disease affecting the esophageal wall.


capillary leak syndrome

description: A syndrome characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure.


name: CXCL9_HUMAN C-X-C motif chemokine 9 (sprot)

description: A C-X-C motif chemokine 9 that is encoded in the genome of human.


meloxicam

A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.


desmoid tumor

description: A desmoid tumor (DT) is a benign, locally invasive soft tissue tumor associated with a high recurrence rate but with no metastatic potential.


PERCHLOROBENZENE

A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.


carbamide peroxide

A mixture obtained by combining equimolar amounts of hydrogen peroxide and urea.


name: ZN384_HUMAN Zinc finger protein 384 (sprot)

description: A zinc finger protein 384 that is encoded in the genome of human.


name: LATS1_HUMAN Serine/threonine-protein kinase LATS1 (sprot)

description: A serine/threonine-protein kinase LATS1 that is encoded in the genome of human.


fosamprenavir

A sulfonamide with a structure based on that of sulfanilamide substituted on the sulfonamide nitrogen by a (2R,3S)-4-phenyl-2-(phosphonooxy)-3-({[(3S)-tetrahydrofuran-3-yloxy]carbonyl}amino)butyl group. It is a pro-drug of the HIV protease inhibitor and antiretroviral drug amprenavir.


neuroendocrine neoplasm

description: Endocrine tumors, also referred to as neuroendocrine tumors (NETs), are defined by a common phenotype which is characterized by the expression of general markers (neuron specific enolase, chromogranin, synaptophysin) and hormone secretion products. These tumors may be localized in any part of the body and are generally discovered in non-specific situations, i.e. not immediately suggestive of NETs (tests for inherited predisposition to tumors or for a clinical syndrome caused by abnormal hormone secretion).


name: TDRD3_HUMAN Tudor domain-containing protein 3 (sprot)

description: A tudor domain-containing protein 3 that is encoded in the genome of human.


name: DLGP3_HUMAN Disks large-associated protein 3 (sprot)

description: A disks large-associated protein 3 that is encoded in the genome of human.


name: RBP56_HUMAN TATA-binding protein-associated factor 2N (sprot)

description: A TATA-binding protein-associated factor 2N that is encoded in the genome of human.


nephritis

description: Inflammation of renal tissue.


ALPHA-NAPHTHOFLAVONE

An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).


name: SCN5A_HUMAN Sodium channel protein type 5 subunit alpha (sprot)

description: A sodium channel protein type 5 subunit alpha that is encoded in the genome of human.


NDRG2_HUMAN Protein NDRG2 (sprot)

A protein NDRG2 that is encoded in the genome of human.


name: RASF1_HUMAN Ras association domain-containing protein 1 (sprot)

description: A Ras association domain-containing protein 1 that is encoded in the genome of human.


name: CD86_HUMAN T-lymphocyte activation antigen CD86 (sprot)

description: A CD86 molecule that is encoded in the genome of human.


aztreonam

A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.


name: MPPA_HUMAN Mitochondrial-processing peptidase subunit alpha (sprot)

description: A mitochondrial-processing peptidase subunit alpha that is encoded in the genome of human.


Abnormality of skin pigmentation

description: An abnormality of the pigmentation of the skin.


name: ROBO4_HUMAN Roundabout homolog 4 (sprot)

description: A roundabout homolog 4 that is encoded in the genome of human.


name: SHPS1_HUMAN Tyrosine-protein phosphatase non-receptor type substrate 1 (sprot)

description: A tyrosine-protein phosphatase non-receptor type substrate 1 that is encoded in the genome of human.


name: NTRK1_HUMAN High affinity nerve growth factor receptor (sprot)

description: A high affinity nerve growth factor receptor that is encoded in the genome of human.


OPSD_HUMAN Rhodopsin (sprot)

A rhodopsin that is encoded in the genome of human.


name: KIF2A_HUMAN Kinesin-like protein KIF2A (sprot)

description: A kinesin-like protein KIF2A that is encoded in the genome of human.


cutaneous neuroendocrine carcinoma

description: Cutaneous neuroendocrine carcinoma is a primary cutaneous cancer arising from a subset of skin neuroendocrine cells (Merkel cells, giving the name Merkel cell carcinoma (MCC)).


mycophenolic acid

A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.


name: ENPP1_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (sprot)

description: An ectonucleotide pyrophosphatase/phosphodiesterase family member 1 that is encoded in the genome of human.


BOREA_HUMAN Borealin (sprot)

A borealin that is encoded in the genome of human.


name: IRG1_HUMAN Cis-aconitate decarboxylase (sprot)

description: An immune-responsive gene 1 protein that is encoded in the genome of human.


name: GDIB_HUMAN Rab GDP dissociation inhibitor beta (sprot)

description: A Rab GDP dissociation inhibitor beta that is encoded in the genome of human.


Coats disease

description: Coats disease (CD) is an idiopathic disorder characterized by retinal telangiectasia with deposition of intraretinal or subretinal exudates, potentially leading to retinal detachment and unilateral blindness. CD is classically an isolated and unilateral condition affecting otherwise healthy young children.


name: ILK_HUMAN Integrin-linked protein kinase (sprot)

description: An integrin-linked protein kinase that is encoded in the genome of human.


name: AT2C1_HUMAN Calcium-transporting ATPase type 2C member 1 (sprot)

description: A calcium-transporting ATPase type 2C member 1 that is encoded in the genome of human.


name: UBP47_HUMAN Ubiquitin carboxyl-terminal hydrolase 47 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 47 that is encoded in the genome of human.


PAROXETINE HYDROCHLORIDE

The hydrochloride salt of paroxetine. It is an antidepressant drug.


name: XPP1_HUMAN Xaa-Pro aminopeptidase 1 (sprot)

description: An Xaa-Pro aminopeptidase 1 that is encoded in the genome of human.


amifostine

An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.


name: ATS3_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 3 (sprot)

description: An a disintegrin and metalloproteinase with thrombospondin motifs 3 that is encoded in the genome of human.


BAFILOMYCIN A1

The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus.


SQSTM_HUMAN Sequestosome-1 (sprot)

A sequestosome-1 that is encoded in the genome of human.


ECT2_HUMAN Protein ECT2 (sprot)

A protein ECT2 that is encoded in the genome of human.


name: KS6A2_HUMAN Ribosomal protein S6 kinase alpha-2 (sprot)

description: A ribosomal protein S6 kinase alpha-2 that is encoded in the genome of human.


name: EYA2_HUMAN Eyes absent homolog 2 (sprot)

description: An eyes absent homolog 2 that is encoded in the genome of human.


name: NOXO1_HUMAN NADPH oxidase organizer 1 (sprot)

description: An NADPH oxidase organizer 1 that is encoded in the genome of human.


name: RM01_HUMAN Large ribosomal subunit protein uL1m (sprot)

description: A large ribosomal subunit protein uL1m that is encoded in the genome of human.


name: RL22_HUMAN Large ribosomal subunit protein eL22 (sprot)

description: A large ribosomal subunit protein eL22 that is encoded in the genome of human.


intellectual disability

description: A broad category of disorders characterized by an impairment to the intelligence an individual possesses. These impairments can result from trauma, birth, or disease and are not restricted to any particular age group.


ponatinib

A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline. It is a multi-target tyrosine kinase inhibitor that targets ABL, SRC, FGFR, and others and was designed to overcome the resistance of BCR-ABL mutation to imatinib, in particular the gatekeeper mutation ABL(T315I).


SODIUM CYANIDE

A cyanide salt containing equal numbers of sodium cations and cyanide anions.


inosine

A purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N(9)-glycosidic bond.


ANACARDIC ACID

A hydroxybenzoic acid that is salicylic acid substituted by a pentadecyl group at position 6. It is a major component of cashew nut shell liquid and exhibits an extensive range of bioactivities.


juvenile idiopathic arthritis

description: Juvenile idiopathic arthritis (JIA) is the term used to describe a group of inflammatory articular disorders of unknown cause that begin before the age of 16 and last over 6 weeks. The term juvenile idiopathic arthritis was chosen to signify the absence of any known mechanism underlying the disorder and to highlight the necessity of excluding other types of arthritis occurring in well defined diseases (in particular arthritis occurring in association with infectious, inflammatory and haematooncologic diseases).


dioscin

A spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage.


name: PTN6_HUMAN Tyrosine-protein phosphatase non-receptor type 6 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 6 that is encoded in the genome of human.


name: SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta (sprot)

description: An amiloride-sensitive sodium channel subunit beta that is encoded in the genome of human.


thyroiditis

description: Inflammation of the thyroid gland. This category includes Hashimoto thyroiditis, Riedel thyroiditis, acute thyroiditis, subacute thyroiditis, and radiation-induced thyroiditis.


MYL3_HUMAN Myosin light chain 3 (sprot)

A myosin light chain 3 that is encoded in the genome of human.


name: DCHS_HUMAN Histidine decarboxylase (sprot)

description: A histidine decarboxylase that is encoded in the genome of human.


selumetinib

A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-chlorophenyl)amino, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor.


acneiform dermatitis

description: Cutaneous eruptions resembling acne, characterized by the presence of papulonodules, pustules, comedones, or cysts in the face, trunk, and extremities. Causes include infections and the use of certain medications (e.g., antibiotics and steroids).


intrahepatic cholestasis

description: A cholestasis characterized by impairment of the bile flow caused by obstruction located in the liver.


trisomy

description: A chromosomal abnormality consisting of the presence of one chromosome in addition to the normal diploid number.


doxazosin

A member of the class of  quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An  antihypertensive agent, it is used in the treatment of high blood pressure.


name: PRGR_HUMAN Progesterone receptor (sprot)

description: A progesterone receptor that is encoded in the genome of human.


ubidecarenone

A ubiquinone having a side chain of 10 isoprenoid units. In the naturally occurring isomer, all isoprenyl double bonds are in the E- configuration.


name: glycogen storage disease due to glucose-6-phosphatase deficiency type IA

description: Glycogenosis due to glucose-6-phosphatase deficiency (G6P) type a, or glycogen storage disease (GSD) type 1a, is a type of glycogenosis due to G6P deficiency.


α-ketoglutaric acid

An oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. It is an intermediate metabolite in Krebs cycle.


name: GLP2R_HUMAN Glucagon-like peptide 2 receptor (sprot)

description: A glucagon-like peptide 2 receptor that is encoded in the genome of human.


name: IQGA3_HUMAN Ras GTPase-activating-like protein IQGAP3 (sprot)

description: A Ras GTPase-activating-like protein IQGAP3 that is encoded in the genome of human.


name: ARHG7_HUMAN Rho guanine nucleotide exchange factor 7 (sprot)

description: A Rho guanine nucleotide exchange factor 7 that is encoded in the genome of human.


name: OFUT1_HUMAN GDP-fucose protein O-fucosyltransferase 1 (sprot)

description: A GDP-fucose protein O-fucosyltransferase 1 that is encoded in the genome of human.


superficial urinary bladder carcinoma

description: A term used by urologists to describe an infiltrating carcinoma of the bladder that has not invaded into the muscularis propria of the bladder wall regardless of histologic type or grade.


name: NCS1_HUMAN Neuronal calcium sensor 1 (sprot)

description: A neuronal calcium sensor 1 that is encoded in the genome of human.


name: YTHD1_HUMAN YTH domain-containing family protein 1 (sprot)

description: A YTH domain-containing family protein 1 that is encoded in the genome of human.


name: YTHD3_HUMAN YTH domain-containing family protein 3 (sprot)

description: A YTH domain-containing family protein 3 that is encoded in the genome of human.


meningioma

description: A generally slow growing tumor attached to the dura mater. It is composed of neoplastic meningothelial (arachnoidal) cells. It typically occurs in adults, often women and it has a wide range of histopathological appearances. Of the various subtypes, meningothelial, fibrous and transitional meningiomas are the most common. Most meningiomas are WHO grade I tumors, and some are WHO grade II or III tumors. Most subtypes share a common clinical behavior, although some subtypes are more likely to recur and follow a more aggressive clinical course. (Adapted from WHO)


RENI_HUMAN Renin (sprot)

A renin that is encoded in the genome of human.


nitrite

The nitrogen oxoanion formed by loss of a proton from nitrous acid.


name: SLIT2_HUMAN Slit homolog 2 protein (sprot)

description: A slit homolog 2 protein that is encoded in the genome of human.


TOB2_HUMAN Protein Tob2 (sprot)

A protein Tob2 that is encoded in the genome of human.


N,N-dimethylglycine

An N-methylglycine that is glycine carrying two N-methyl substituents.


name: CIP4_HUMAN Cdc42-interacting protein 4 (sprot)

description: A Cdc42-interacting protein 4 that is encoded in the genome of human.


pentanoic acid

A straight-chain saturated fatty acid containing five carbon atoms.


name: SENP1_HUMAN Sentrin-specific protease 1 (sprot)

description: A sentrin-specific protease 1 that is encoded in the genome of human.


name: FPR2_HUMAN N-formyl peptide receptor 2 (sprot)

description: An N-formyl peptide receptor 2 that is encoded in the genome of human.


name: LSP1_HUMAN Lymphocyte-specific protein 1 (sprot)

description: A lymphocyte-specific protein 1 that is encoded in the genome of human.


name: KI20A_HUMAN Kinesin-like protein KIF20A (sprot)

description: A kinesin-like protein KIF20A that is encoded in the genome of human.


L-valine

The L-enantiomer of valine.


rectal cancer

description: A primary or metastatic malignant neoplasm that affects the rectum. Representative examples include carcinoma, lymphoma, and sarcoma.


name: ATP5J_HUMAN ATP synthase-coupling factor 6, mitochondrial (sprot)

description: An ATP synthase-coupling factor 6, mitochondrial that is encoded in the genome of human.


alprazolam

A member of the class of triazolobenzodiazepines that is 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine carrying methyl, phenyl and chloro substituents at positions 1, 6 and 8 respectively. Alprazolam is only found in individuals that have taken this drug.


icosapent

A long-chain fatty acid ethyl ester resulting from the formal condensation of the carboxy group of (5Z,8Z,11Z,14Z,17Z)-icosapentaenoic acid with the hydroxy group of ethanol.


name: NOTC4_HUMAN Neurogenic locus notch homolog protein 4 (sprot)

description: A neurogenic locus notch homolog protein 4 that is encoded in the genome of human.


FCN3_HUMAN Ficolin-3 (sprot)

A ficolin-3 that is encoded in the genome of human.


name: KCNJ2_HUMAN Inward rectifier potassium channel 2 (sprot)

description: An inward rectifier potassium channel 2 that is encoded in the genome of human.


Pauci-immune glomerulonephritis

description: Pauci-immune glomerulonephritis (GN) is one of the most frequent causes of rapidly progressive GN (RPGN). It is characterized clinically by renal manifestations of RPGN (hematuria, hypertension) leading to renal failure within days or weeks, and may be associated with manifestations of systemic vasculitis (arthralgia, fever, seizures, mono neuritis and lung involvement). Pauci-immune GN is histologically characterized by focal necrotizing and crescentic GN, with mild or absent glomerular staining for immunoglobulin and complement by fluorescence microscopy, which may manifest either as part of a systemic small vessel vasculitis (including microscopic polyangiitis, granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis), or rarely as part of renal-limited vasculitis (RLV, idiopathic crescentic GN). Immunologic classification is based on the presence or absence of circulating anti-neutrophil cytoplasmic antibodies (ANCAs), namely pauci-immune-GN with ANCA and pauci-immune GN without ANCA.


deferiprone

A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.


name: SIA8A_HUMAN Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (sprot)

description: An alpha-N-acetylneuraminide alpha-2,8-sialyltransferase that is encoded in the genome of human.


GRN_HUMAN Progranulin (sprot)

A progranulin that is encoded in the genome of human.


ofatumumab

An ether in which the oxygen atom is connected to two methyl groups.


multiple endocrine neoplasia type 1

description: Multiple endocrine neoplasia Type 1 (MEN1) is a frequent form of MEN, a rare inherited cancer syndrome, characterized by the development of neuroendocrine tumors of the parathyroid, pancreas, and anterior pituitary gland, and less commonly the adrenal cortical gland, with other non-endocrine tumors in some patients.


lymphoproliferative syndrome

description: A disorder characterized by proliferation of lymphocytes at various stages of differentiation. Lymphoproliferative disorders can be neoplastic (clonal, as in lymphomas and leukemias) or reactive (polyclonal, as in infectious mononucleosis).


Left ventricular systolic dysfunction

description: Abnormality of left ventricular contraction, often defined operationally as an ejection fraction of less than 40 percent.


name: DEP1B_HUMAN DEP domain-containing protein 1B (sprot)

description: A DEP domain-containing protein 1B that is encoded in the genome of human.


myricetin

A hexahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 3', 4', 5, 5' and 7. It has been isolated from the leaves of Myrica rubra and other plants.


name: TRI27_HUMAN Zinc finger protein RFP (sprot)

description: A zinc finger protein RFP that is encoded in the genome of human.


name: MOB1A_HUMAN MOB kinase activator 1A (sprot)

description: A MOB kinase activator 1A that is encoded in the genome of human.


lung carcinoma

description: A carcinoma that arises from epithelial cells of the lung


N,N-dimethylacetamide

A member of the class of  acetamides that is  acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism.


name: ORC6_HUMAN Origin recognition complex subunit 6 (sprot)

description: An origin recognition complex subunit 6 that is encoded in the genome of human.


name: KCNJ1_HUMAN ATP-sensitive inward rectifier potassium channel 1 (sprot)

description: An ATP-sensitive inward rectifier potassium channel 1 that is encoded in the genome of human.


von Willebrand disease 1

description: Type 1 von Willebrand disease (type 1 VWD) is a form of VWD characterized by a bleeding disorder associated with a partial quantitative plasmatic deficiency of an otherwise structurally and functionally normal Willebrand factor (von Willebrand factor; VWF).


leiomyosarcoma

description: An uncommon, aggressive malignant smooth muscle neoplasm, usually occurring in post-menopausal women. It is characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid, granular cell, inflammatory and myxoid leimyosarcomas.


name: PRIC1_HUMAN Prickle-like protein 1 (sprot)

description: A prickle-like protein 1 that is encoded in the genome of human.


mosapride

A benzamide resulting from the formal condensation of the carboxy group of 4-amino-5-chloro-2-ethoxybenzoic acid with the amino group of 1-[4-(4-fluorobenzyl)morpholin-2-yl]methanamine.


alopecia areata

description: Loss of scalp and body hair involving microscopically inflammatory patchy areas.


name: TRI25_HUMAN E3 ubiquitin/ISG15 ligase TRIM25 (sprot)

description: An E3 ubiquitin/ISG15 ligase TRIM25 that is encoded in the genome of human.


DYN3_HUMAN Dynamin-3 (sprot)

A dynamin-3 that is encoded in the genome of human.


TLN2_HUMAN Talin-2 (sprot)

A talin-2 that is encoded in the genome of human.


name: COMD1_HUMAN COMM domain-containing protein 1 (sprot)

description: A COMM domain-containing protein 1 that is encoded in the genome of human.


name: ANPRC_HUMAN Atrial natriuretic peptide receptor 3 (sprot)

description: An atrial natriuretic peptide receptor 3 that is encoded in the genome of human.


ofloxacin

An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.


thiomersal

An alkylmercury compound (approximately 49% mercury by weight) used as an antiseptic and antifungal agent.


mucositis

description: Inflammation of the mucous membranes.


nicardipine

A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.


name: CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E (sprot)

description: A voltage-dependent R-type calcium channel subunit alpha-1E that is encoded in the genome of human.


Crimean-Congo hemorrhagic fever

description: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic disease caused by CCHF virus and characterized by initial fever, headache, and malaise followed by gastrointestinal symptoms and, in severe cases, bleeding, shock, and multi-organ system failure.


vamorolone

A 3-oxo-Delta(1),Delta(4)-steroid that is pregna-1,4,9(11)-trien-17-ol substituted by oxo, oxo, and hydroxy groups at positions 3, 20, and 21, respectively. It is approved by the FDA for the treatment of patients with Duchenne muscular dystrophy aged 2 years and older.


diffuse intrinsic pontine glioma

description: A neuroglial tumor that arises from the middle portion of the brain stem. It usually affects children and has a poor prognosis.


name: MRGX2_HUMAN Mas-related G-protein coupled receptor member X2 (sprot)

description: A Mas-related G-protein coupled receptor X2 that is encoded in the genome of human.


phosphatidylethanolamine (24:0/18:1)

1,2-diacyl-sn-glycero-3-phosphoethanolamine in which the acyl group at C-1 contains 24 carbons and no double bonds while that at C-2 contains 18 carbons and 1 double bond.


tazobactam

A member of the class of penicillanic acids that is sulbactam in which one of the exocyclic methyl hydrogens is replaced by a 1,2,3-triazol-1-yl group; used (in the form of its sodium salt) in combination with ceftolozane sulfate for treatment of complicated intra-abdominal infections and complicated urinary tract infections.


GKN1_HUMAN Gastrokine-1 (sprot)

A gastrokine-1 that is encoded in the genome of human.


name: ATAD2_HUMAN ATPase family AAA domain-containing protein 2 (sprot)

description: An ATPase family AAA domain-containing protein 2 that is encoded in the genome of human.


name: EOMES_HUMAN Eomesodermin homolog (sprot)

description: An eomesodermin that is encoded in the genome of human.


name: SSR3_HUMAN Somatostatin receptor type 3 (sprot)

description: A somatostatin receptor type 3 that is encoded in the genome of human.


WNT7A_HUMAN Protein Wnt-7a (sprot)

A protein Wnt-7a that is encoded in the genome of human.


potassium hydrogencarbonate

A potassium salt that is the monopotassium salt of carbonic acid. It has fungicidal properties and is used in organic farming for the control of powdery mildew and apple scab.


Pneumocystis infectious disease

description: Infections with species in the genus pneumocystis, a fungus causing interstitial plasma cell pneumonia (pneumonia, pneumocystis) and other infections in humans and other mammals. Immunocompromised patients, especially those with aids, are particularly susceptible to these infections. Extrapulmonary sites are rare but seen occasionally.


name: STIP1_HUMAN Stress-induced-phosphoprotein 1 (sprot)

description: A stress-induced-phosphoprotein 1 that is encoded in the genome of human.


name: CDC37_HUMAN Hsp90 co-chaperone Cdc37 (sprot)

description: An Hsp90 co-chaperone Cdc37 that is encoded in the genome of human.


CFAD_HUMAN Complement factor D (sprot)

A complement factor D that is encoded in the genome of human.


name: MARH5_HUMAN E3 ubiquitin-protein ligase MARCHF5 (sprot)

description: An E3 ubiquitin-protein ligase MARCHF5 that is encoded in the genome of human.


name: GLT18_HUMAN Polypeptide N-acetylgalactosaminyltransferase 18 (sprot)

description: A polypeptide N-acetylgalactosaminyltransferase 18 that is encoded in the genome of human.


clear cell renal carcinoma

description: A malignant epithelial neoplasm of the kidney characterized by the presence of lipid-containing clear cells within a vascular network. The tumor may metastasize to unusual sites and late metastasis is common.


name: FOXQ1_HUMAN Forkhead box protein Q1 (sprot)

description: A forkhead box protein Q1 that is encoded in the genome of human.


name: MARK3_HUMAN MAP/microtubule affinity-regulating kinase 3 (sprot)

description: A MAP/microtubule affinity-regulating kinase 3 that is encoded in the genome of human.


pulmonary blastoma

description: A malignant neoplasm of the lung composed of tubular structures and immature mesenchymal elements, which may differentiate towards skeletal and smooth muscle, cartilage or a combination of muscle and cartilage. This is a nodular tumor found in the periphery of the lung. It can occur at any age. The prognosis is related to the stage of the disease at the time of resection. Pulmonary blastoma is divided into two subtypes: epithelial predominant and biphasic.


daclatasvir

A member of the class of biphenyls that is a potent inhibitor of nonstructural protein 5A and is used (as its hydrochloride salt) for treatment of hepatitis C.


name: SO1B1_HUMAN Solute carrier organic anion transporter family member 1B1 (sprot)

description: A solute carrier organic anion transporter family member 1B1 that is encoded in the genome of human.


name: UPAR_HUMAN Urokinase plasminogen activator surface receptor (sprot)

description: A urokinase plasminogen activator surface receptor that is encoded in the genome of human.


pictilisib

A sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring.


MYH7_HUMAN Myosin-7 (sprot)

A myosin-7 that is encoded in the genome of human.


name: TRI29_HUMAN Tripartite motif-containing protein 29 (sprot)

description: A tripartite motif-containing protein 29 that is encoded in the genome of human.


alvocidib

A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.


pneumonitis

description: An inflammatory process affecting the lung parenchyma. It is a milder form of lung inflammation compared to pneumonia.


name: IL1AP_HUMAN Interleukin-1 receptor accessory protein (sprot)

description: An interleukin-1 receptor accessory protein that is encoded in the genome of human.


name: MYD88_HUMAN Myeloid differentiation primary response protein MyD88 (sprot)

description: A myeloid differentiation primary response protein MyD88 that is encoded in the genome of human.


AMPN_HUMAN Aminopeptidase N (sprot)

An aminopeptidase N that is encoded in the genome of human.


feline infectious peritonitis

description: Common coronavirus infection of cats caused by the feline infectious peritonitis virus (coronavirus, feline). The disease is characterized by a long incubation period, fever, depression, loss of appetite, wasting, and progressive abdominal enlargement. Infection of cells of the monocyte-macrophage lineage appears to be essential in FIP pathogenesis.


A secondary carboxamide resulting from the formal condensation of the carboxy group of piperidine-4-carboxylic acid with the amino group of 5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-amine. It is an ATP-competitive inhibitor of CDK2, CDK7 and CDK9 kinases and exhibits anti-cancer properties.


name: PK3CB_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (sprot)

description: A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform that is encoded in the genome of human.