aldosterone

A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.


HEPC_HUMAN Hepcidin (sprot)

A hepcidin that is encoded in the genome of human.


obeticholic acid

A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis.


name: NOS1_HUMAN Nitric oxide synthase 1 (sprot)

description: A nitric oxide synthase 1 that is encoded in the genome of human.


maltose

A glycosylglucose consisting of two D-glucopyranose units connected by an alpha-(1->4)-linkage.


type 2 diabetes mellitus

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.


name: ABL1_HUMAN Tyrosine-protein kinase ABL1 (sprot)

description: A tyrosine-protein kinase ABL1 that is encoded in the genome of human.


TOP1_HUMAN DNA topoisomerase 1 (sprot)

A type 1B DNA topoisomerase 1 that is encoded in the genome of human.


paroxysmal dystonia

description: A form of dystonia characterized by episodes of dystonia (often hemidystonia or generalized) lasting from minutes to hours. There are no dystonic symptoms between episodes.


beta-L-fructofuranose

A L-fructofuranose with a beta-configuration at the anomeric position.


name: ACTA_HUMAN Actin, aortic smooth muscle (sprot)

description: An actin, aortic smooth muscle that is encoded in the genome of human.


name: ATF3_HUMAN Cyclic AMP-dependent transcription factor ATF-3 (sprot)

description: A cyclic AMP-dependent transcription factor ATF-3 that is encoded in the genome of human.


name: STF1_HUMAN Steroidogenic factor 1 (sprot)

description: A steroidogenic factor 1 that is encoded in the genome of human.


CETYLPYRIDINIUM CHLORIDE

A pyridinium salt that has N-hexadecylpyridinium as the cation and chloride as the anion. It has antiseptic properties and is used in solutions or lozenges for the treatment of minor infections of the mouth and throat.


osteosarcoma

description: A usually aggressive malignant bone-forming mesenchymal neoplasm, predominantly affecting adolescents and young adults. It usually involves bones and less frequently extraosseous sites. It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus). Pain with or without a palpable mass is the most frequent clinical symptom. It may spread to other anatomic sites, particularly the lungs.


valproic acid

A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.


mesothelioma

description: A usually malignant and aggressive neoplasm of the mesothelium which is often associated with exposure to asbestos.


name: SFRP2_HUMAN Secreted frizzled-related protein 2 (sprot)

description: A secreted frizzled-related protein 2 that is encoded in the genome of human.


name: MSX1_HUMAN Homeobox protein MSX-1 (sprot)

description: A homeobox protein MSX-1 that is encoded in the genome of human.


desipramine

A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.


citric acid

A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.


EDN2_HUMAN Endothelin-2 (sprot)

An endothelin-2 that is encoded in the genome of human.


chlordiazepoxide

A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.


name: S26A1_HUMAN Sulfate anion transporter 1 (sprot)

description: A sulfate anion transporter 1 that is encoded in the genome of human.


name: CREB1_HUMAN Cyclic AMP-responsive element-binding protein 1 (sprot)

description: A cyclic AMP-responsive element-binding protein 1 that is encoded in the genome of human.


name: CRTC1_HUMAN CREB-regulated transcription coactivator 1 (sprot)

description: A CREB-regulated transcription coactivator 1 that is encoded in the genome of human.


name: IRX4_HUMAN Iroquois-class homeodomain protein IRX-4 (sprot)

description: An iroquois-class homeodomain protein IRX-4 that is encoded in the genome of human.


name: S53A1_HUMAN Solute carrier family 53 member 1 (sprot)

description: A solute carrier family 53 member 1 that is encoded in the genome of human.


D-ASPARTATE

The D-enantiomer of aspartic acid.


dystonic disorder

description: A movement disorder characterized by sustained or intermittent muscle contractions, resulting in abnormal movements and/or postures.


vasculitis

description: Vasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. Behcet disease) to relatively minor skin disease.


NECT2_HUMAN Nectin-2 (sprot)

A nectin-2 that is encoded in the genome of human.


name: NKG2C_HUMAN NKG2-C type II integral membrane protein (sprot)

description: An NKG2-C type II integral membrane protein that is encoded in the genome of human.


fenbendazole

A member of the class of benzimidazoles that is 1H-benzimidazole  which is substituted at positons 2 and 5 by (methoxycarbonyl)amino and phenylsulfanediyl groups, respectively. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections.


name: GLUT4_HUMAN Solute carrier family 2, facilitated glucose transporter member 4 (sprot)

description: A solute carrier family 2, facilitated glucose transporter member 4 that is encoded in the genome of human.


acetylcysteine

An  N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.


clioquinol

A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.


ITLN1_HUMAN Intelectin-1 (sprot)

An intelectin-1 that is encoded in the genome of human.


eflornithine

A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.


sarcomatoid carcinoma

description: A malignant epithelial neoplasm characterized by the presence of spindle cells and anaplastic morphologic features. Giant cells and a sarcomatous component may also be present.


ANXA5_HUMAN Annexin A5 (sprot)

An annexin A5 that is encoded in the genome of human.


name: TNF12_HUMAN Tumor necrosis factor ligand superfamily member 12 (sprot)

description: A tumor necrosis factor ligand superfamily member 12 that is encoded in the genome of human.


name: TBCD4_HUMAN TBC1 domain family member 4 (sprot)

description: A TBC1 domain family member 4 that is encoded in the genome of human.


name: STA5B_HUMAN Signal transducer and activator of transcription 5B (sprot)

description: A signal transducer and activator of transcription 5b that is encoded in the genome of human.


name: MYDGF_HUMAN Myeloid-derived growth factor (sprot)

description: A myeloid-derived growth factor that is encoded in the genome of human.


name: ZO1_HUMAN Tight junction protein ZO-1 (sprot)

description: A tight junction protein ZO-1 that is encoded in the genome of human.


L-ornithine

An optically active form of ornithine having L-configuration.


Stargardt disease

description: Stargardt disease, also known as Stargardt 1 (STGD1), is an autosomal recessive form of retinal dystrophy that is usually characterized by a progressive loss of central vision associated with irregular macular and perimacular yellow-white fundus flecks, and a so-called ''beaten bronze'' atrophic central macular lesion.


S100P_HUMAN Protein S100-P (sprot)

A protein S100-P that is encoded in the genome of human.


name: CCR5_HUMAN C-C chemokine receptor type 5 (sprot)

description: A C-C chemokine receptor type 5 that is encoded in the genome of human.


name: AT2A2_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (sprot)

description: A sarcoplasmic/endoplasmic reticulum calcium ATPase 2 that is encoded in the genome of human.


name: ERN1_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE1 (sprot)

description: A serine/threonine-protein kinase/endoribonuclease IRE1 that is encoded in the genome of human.


name: TF7L1_HUMAN Transcription factor 7-like 1 (sprot)

description: A transcription factor 7-like 1 that is encoded in the genome of human.


name: PO5F1_HUMAN POU domain, class 5, transcription factor 1 (sprot)

description: A POU domain, class 5, transcription factor 1 that is encoded in the genome of human.


name: S15A2_HUMAN Solute carrier family 15 member 2 (sprot)

description: A solute carrier family 15 member 2 that is encoded in the genome of human.


name: CEAM1_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 1 (sprot)

description: A carcinoembryonic antigen-related cell adhesion molecule 1 that is encoded in the genome of human.


name: ADT1_HUMAN ADP/ATP translocase 1 (sprot)

description: An ADP/ATP translocase 1 that is encoded in the genome of human.


name: HSPB2_HUMAN Heat shock protein beta-2 (sprot)

description: A heat shock protein beta-2 that is encoded in the genome of human.


A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.


name: CPT2_HUMAN Carnitine O-palmitoyltransferase 2, mitochondrial (sprot)

description: A carnitine O-palmitoyltransferase 2, mitochondrial that is encoded in the genome of human.


carvedilol

A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.


familial dilated cardiomyopathy

description: A a genetic form of heart disease that occurs when heart (cardiac) muscle becomes thin and weakened in at least one chamber of the heart, causing the open area of the chamber to become enlarged (dilated). As a result, the heart is unable to pump blood as efficiently as usual. To compensate, the heart attempts to increase the amount of blood being pumped through the heart, leading to further thinning and weakening of the cardiac muscle. Over time, this condition results in heart failure.


name: PRRX1_HUMAN Paired mesoderm homeobox protein 1 (sprot)

description: A paired mesoderm homeobox protein 1 that is encoded in the genome of human.


name: NUP98_HUMAN Nuclear pore complex protein Nup98-Nup96 (sprot)

description: A nuclear pore complex protein Nup98-Nup96 that is encoded in the genome of human.


name: VEGFA_HUMAN Vascular endothelial growth factor A, long form (sprot)

description: A vascular endothelial growth factor A, long form that is encoded in the genome of human.


oseltamivir

A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.


name: IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (sprot)

description: An interleukin-1 receptor-associated kinase 4 that is encoded in the genome of human.


OSTP_HUMAN Osteopontin (sprot)

An osteopontin that is encoded in the genome of human.


name: EPCAM_HUMAN Epithelial cell adhesion molecule (sprot)

description: An epithelial cell adhesion molecule that is encoded in the genome of human.


testosterone

An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..


name: SMAD4_HUMAN Mothers against decapentaplegic homolog 4 (sprot)

description: A smad4 that is encoded in the genome of human.


name: EMC5_HUMAN ER membrane protein complex subunit 5 (sprot)

description: An ER membrane protein complex subunit 5 that is encoded in the genome of human.


name: EMC9_HUMAN ER membrane protein complex subunit 9 (sprot)

description: An ER membrane protein complex subunit 9 that is encoded in the genome of human.


name: FBXW7_HUMAN F-box/WD repeat-containing protein 7 (sprot)

description: An F-box/WD repeat-containing protein 7 that is encoded in the genome of human.


HEXI1_HUMAN Protein HEXIM1 (sprot)

A protein HEXIM1 that is encoded in the genome of human.


name: CDK1_HUMAN Cyclin-dependent kinase 1 (sprot)

description: A cyclin-dependent kinase 1 that is encoded in the genome of human.


name: OTUB1_HUMAN Ubiquitin thioesterase OTUB1 (sprot)

description: A ubiquitin thioesterase OTUB1 that is encoded in the genome of human.


TLR3_HUMAN Toll-like receptor 3 (sprot)

A Toll-like receptor 3 that is encoded in the genome of human.


aldehydo-D-mannose

The D-enantiomer of aldehydo-mannose.


bacteriuria

description: The presence of bacteria in the urine which is normally bacteria-free. These bacteria are from the urinary tract and are not contaminants of the surrounding tissues. Bacteriuria can be symptomatic or asymptomatic. Significant bacteriuria is an indicator of urinary tract infection.


name: FIS1_HUMAN Mitochondrial fission 1 protein (sprot)

description: A mitochondrial fission 1 protein that is encoded in the genome of human.


SEM6A_HUMAN Semaphorin-6A (sprot)

A semaphorin-6A that is encoded in the genome of human.


name: RNF12_HUMAN E3 ubiquitin-protein ligase RLIM (sprot)

description: An E3 ubiquitin-protein ligase RLIM that is encoded in the genome of human.


name: DLX5_HUMAN Homeobox protein DLX-5 (sprot)

description: A homeobox protein DLX-5 that is encoded in the genome of human.


TLR9_HUMAN Toll-like receptor 9 (sprot)

A Toll-like receptor 9 that is encoded in the genome of human.


name: SNAI2_HUMAN Zinc finger protein SNAI2 (sprot)

description: A zinc finger protein SNAI2 that is encoded in the genome of human.


malignant peripheral nerve sheath tumor

description: Malignant peripheral nerve sheath tumor (MPNST) is a rare and often aggressive soft tissue sarcoma occurring in a wide range of anatomical sites.


D-alanine

The D-enantiomer of alanine.


name: SLN11_HUMAN Schlafen family member 11 (sprot)

description: A Schlafen family member 11 that is encoded in the genome of human.


name: FCG2A_HUMAN Low affinity immunoglobulin gamma Fc region receptor II-a (sprot)

description: A low affinity immunoglobulin gamma Fc region receptor II-a that is encoded in the genome of human.


name: ARI4A_HUMAN AT-rich interactive domain-containing protein 4A (sprot)

description: An AT-rich interactive domain-containing protein 4A that is encoded in the genome of human.


name: DPYL5_HUMAN Dihydropyrimidinase-related protein 5 (sprot)

description: A dihydropyrimidinase-related protein 5 that is encoded in the genome of human.


ankylosing spondylitis

description: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.


name: CNDG2_HUMAN Condensin-2 complex subunit G2 (sprot)

description: A condensin-2 complex subunit G2 that is encoded in the genome of human.


isoprenaline

A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.


name: SODE_HUMAN Extracellular superoxide dismutase [Cu-Zn] (sprot)

description: An extracellular superoxide dismutase [Cu-Zn] that is encoded in the genome of human.


6-aminocaproic acid

An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.


name: GDF9_HUMAN Growth/differentiation factor 9 (sprot)

description: A growth/differentiation factor 9 that is encoded in the genome of human.


name: CML2_HUMAN Chemerin-like receptor 2 (sprot)

description: A chemerin-like receptor 2 that is encoded in the genome of human.


name: P55G_HUMAN Phosphatidylinositol 3-kinase regulatory subunit gamma (sprot)

description: A phosphatidylinositol 3-kinase regulatory subunit gamma that is encoded in the genome of human.


name: RAB15_HUMAN Ras-related protein Rab-15 (sprot)

description: A Ras-related protein Rab-15 that is encoded in the genome of human.


GEMCITABINE HYDROCHLORIDE

A 2'-deoxycytidine hydrochloriode having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine hydrochloride is used in the treatment of various carcinomas, including non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.


name: LOX5_HUMAN Polyunsaturated fatty acid 5-lipoxygenase (sprot)

description: A polyunsaturated fatty acid 5-lipoxygenase that is encoded in the genome of human.


clavulanic acid

Antibiotic isolated from Streptomyces clavuligerus. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes.


catechin

The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.


anxiety

description: Apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus.


FBN1_HUMAN Fibrillin-1 (sprot)

A fibrillin-1 that is encoded in the genome of human.


ticlopidine

A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.


name: SPHK1_HUMAN Sphingosine kinase 1 (sprot)

description: A sphingosine kinase 1 that is encoded in the genome of human.


name: RND1_HUMAN Rho-related GTP-binding protein Rho6 (sprot)

description: A Rho-related GTP-binding protein Rho6 that is encoded in the genome of human.


name: PGSF1_HUMAN Putative uncharacterized protein encoded by MIR7-3HG (sprot)

description: A pituitary gland-specific factor 1 that is encoded in the genome of human.


name: BAK_HUMAN Bcl-2 homologous antagonist/killer (sprot)

description: A Bcl-2 homologous antagonist/killer that is encoded in the genome of human.


CCN1_HUMAN CCN family member 1 (sprot)

A CCN family member 1 that is encoded in the genome of human.


IL2_HUMAN Interleukin-2 (sprot)

An interleukin-2 that is encoded in the genome of human.


sterculic acid

A long-chain, monounsaturated fatty acid composed of 9-octadecenoic acid having a 9,10-cyclopropenyl group.


name: MSMO1_HUMAN Methylsterol monooxygenase 1 (sprot)

description: A methylsterol monooxygenase 1 that is encoded in the genome of human.


name: BCL3_HUMAN B-cell lymphoma 3 protein (sprot)

description: A B-cell lymphoma 3 protein that is encoded in the genome of human.


polycystic ovary syndrome

description: A disorder that manifests as multiple cysts on the ovaries. It results in hormonal imbalances and leads to irregular and abnormal menstrual periods, excess growth of hair, acne eruptions and obesity.


name: CX3C1_HUMAN CX3C chemokine receptor 1 (sprot)

description: A CX3C chemokine receptor 1 that is encoded in the genome of human.


cilnidipine

A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.


name: CPT1A_HUMAN Carnitine O-palmitoyltransferase 1, liver isoform (sprot)

description: A carnitine O-palmitoyltransferase 1, liver isoform that is encoded in the genome of human.


fampridine

An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.


Vestibular hypofunction

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A general descriptive term that describes impaired functioning of the vestibular apparatus that leads to manifestations such as dizziness or postural imbalance


acquired polycythemia vera

description: Polycythemia vera (PV) is an acquired myeloproliferative disorder characterized by an elevated absolute red blood cell mass caused by uncontrolled red blood cell production, frequently associated with uncontrolled white blood cell and platelet production.


name: KCNC1_HUMAN Potassium voltage-gated channel subfamily C member 1 (sprot)

description: A voltage-gated potassium channel KCNC1 that is encoded in the genome of human.


name: CNPY2_HUMAN Protein canopy homolog 2 (sprot)

description: A protein canopy homolog 2 that is encoded in the genome of human.


D103A_HUMAN Beta-defensin 103 (sprot)

A beta-defensin 103 that is encoded in the genome of human.


MORPHOLINE

An organic heteromonocyclic compound whose six-membered ring contains four carbon atoms and one nitrogen atom and one oxygen atom that lies opposite to each other; the parent compound of the morpholine family.


name: OLFL3_HUMAN Olfactomedin-like protein 3 (sprot)

description: An olfactomedin-like protein 3 that is encoded in the genome of human.


chondromalacia

description: Pathological processes involving the chondral tissue (cartilage).


cefepime

A cephalosporin bearing (1-methylpyrrolidinium-1-yl)methyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.


pyelonephritis

description: An inflammatory process affecting the kidney. The cause is most often bacterial, but may also be fungal in nature. Signs and symptoms may include fever, chills, flank pain, painful and frequent urination, cloudy or bloody urine, and confusion.


hydroquinone

A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.


cerebral infarction

description: An ischemic condition of the brain, producing a persistent focal neurological deficit in the area of distribution of the cerebral arteries.


A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. The principal psychoactive constituent of the cannabis plant, it is used for treatment of anorexia associated with AIDS as well as nausea and vomiting associated with cancer chemotherapy.


name: CCL5_HUMAN C-C motif chemokine 5 (sprot)

description: A C-C motif chemokine 5 that is encoded in the genome of human.


name: CSRP2_HUMAN Cysteine and glycine-rich protein 2 (sprot)

description: A cysteine and glycine-rich protein 2 that is encoded in the genome of human.


name: TRPC4_HUMAN Short transient receptor potential channel 4 (sprot)

description: A short transient receptor potential cation channel TRPC4 that is encoded in the genome of human.


beta-D-glucoside

Any D-glucoside in which the anomeric centre has beta-configuration.


name: NOTC1_HUMAN Neurogenic locus notch homolog protein 1 (sprot)

description: A neurogenic locus notch homolog protein 1 that is encoded in the genome of human.


ANTHRANILIC ACID

An aminobenzoic acid that is benzoic acid having a single amino substituent located at position 2. It is a metabolite produced in L-tryptophan-kynurenine pathway in the central nervous system.


rheumatoid arthritis

description: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.


diacylglycerol (18:0/22:4/0:0)

A 1,2-diglyceride in which the fatty acyl groups at positions 1 and 2 are specified as C18:0 and C22:4 respectively.


name: AKT3_HUMAN RAC-gamma serine/threonine-protein kinase (sprot)

description: A RAC-gamma serine/threonine-protein kinase that is encoded in the genome of human.


name: THIL_HUMAN Acetyl-CoA acetyltransferase, mitochondrial (sprot)

description: An acetyl-CoA acetyltransferase, mitochondrial that is encoded in the genome of human.


everolimus

A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted into the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent.


name: autosomal dominant polycystic kidney disease

description: Autosomal dominant form of polycystic kidney disease.


rimonabant

A carbohydrazide obtained by formal condensation of the carboxy group of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. It is a potent and selective cannabinoid receptor 1 (CB1R) antagonist. Besides its antagonistic properties, numerous studies have shown that, at micromolar concentrations rimonabant behaves as an inverse agonist at CB1 receptors. The drug was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was later withdrawn from market due to CNS-related adverse effects including depression and suicidal ideation.


name: AKT2_HUMAN RAC-beta serine/threonine-protein kinase (sprot)

description: A RAC-beta serine/threonine-protein kinase that is encoded in the genome of human.


methimazole

A member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen.


aplastic anemia

description: Anemia resulting from bone marrow failure (aplastic or hypoplastic bone marrow). The production of erythroblasts and red cells is markedly decreased, and it may be associated with decreased production of granulocytes (granulocytopenia) and platelets (thrombocytopenia) as well. Aplastic anemia may be idiopathic or secondary due to bone marrow damage by toxins, radiation, or immunologic factors.


name: NOS2_HUMAN Nitric oxide synthase, inducible (sprot)

description: A nitric oxide synthase, inducible that is encoded in the genome of human.


metolazone

A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.


nephrotic syndrome

description: A collection of symptoms that include severe edema, proteinuria, and hypoalbuminemia; it is indicative of renal dysfunction.


amineptine

A carbocyclic fatty acid that is 5-aminoheptanoic acid in which one of the hydrogens attached to the nitrogen is replaced by a 10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl group. A tricyclic antidepressant, it was never approved in the US and was withdrawn from the French market in 1999 due to concerns over abuse, dependence and severe acne.


nitrate

A nitrogen oxoanion formed by loss of a proton from nitric acid. Principal species present at pH 7.3.


cirrhosis of liver

description: A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.


CAD19_HUMAN Cadherin-19 (sprot)

A cadherin-19 that is encoded in the genome of human.


name: GRIA2_HUMAN Glutamate receptor 2 (sprot)

description: A glutamate receptor 2 that is encoded in the genome of human.


dichloroacetic acid

An organochlorine compound comprising acetic acid carrying two chloro substituents at the 2-position. It occurs in nature in seaweed, Asparagopsis taxiformis.


name: CDK2_HUMAN Cyclin-dependent kinase 2 (sprot)

description: A cyclin-dependent kinase 2 that is encoded in the genome of human.


fluphenazine

A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position.


name: PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2 (sprot)

description: An 85/88 kDa calcium-independent phospholipase A2 that is encoded in the genome of human.


FENRETINIDE

A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.


name: HES1_HUMAN Transcription factor HES-1 (sprot)

description: A transcription factor HES-1 that is encoded in the genome of human.


oxcarbazepine

A dibenzoazepine derivative, having a carbamoyl group at the ring nitrogen, substituted with an oxo group at C-4 of the azepeine ring which is also hydrogenated at C-4 and C-5. It is a anticholinergic anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy.


name: FBXL5_HUMAN F-box/LRR-repeat protein 5 (sprot)

description: An F-box/LRR-repeat protein 5 that is encoded in the genome of human.


name: ALKB5_HUMAN RNA demethylase ALKBH5 (sprot)

description: An alkylated DNA repair protein alkB 5 that is encoded in the genome of human.


MYOM2_HUMAN Myomesin-2 (sprot)

A myomesin-2 that is encoded in the genome of human.


name: XIRP2_HUMAN Xin actin-binding repeat-containing protein 2 (sprot)

description: An Xin actin-binding repeat-containing protein 2 that is encoded in the genome of human.


ruxolitinib

A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis.


quercetin

A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.


name: SMAD1_HUMAN Mothers against decapentaplegic homolog 1 (sprot)

description: A smad1 that is encoded in the genome of human.


glucagon

A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.


name: FACD2_HUMAN Fanconi anemia group D2 protein (sprot)

description: A Fanconi anemia group D2 protein that is encoded in the genome of human.


name: IHH_HUMAN Indian hedgehog protein (sprot)

description: An Indian hedgehog protein that is encoded in the genome of human.


morphine

A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).


name: PA2G5_HUMAN Phospholipase A2 group V (sprot)

description: A phospholipase A2 group V that is encoded in the genome of human.


glucose intolerance

description: The inability to regulate blood glucose levels resulting in hyperglycemia.


amodiaquine

A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.


name: PEX14_HUMAN Peroxisomal membrane protein PEX14 (sprot)

description: A peroxisomal membrane protein PEX14 that is encoded in the genome of human.


name: S27A2_HUMAN Long-chain fatty acid transport protein 2 (sprot)

description: A long-chain fatty acid transport protein 2 that is encoded in the genome of human.


name: SIL1_HUMAN Nucleotide exchange factor SIL1 (sprot)

description: A nucleotide exchange factor SIL1 that is encoded in the genome of human.


name: EAA1_HUMAN Excitatory amino acid transporter 1 (sprot)

description: An excitatory amino acid transporter 1 that is encoded in the genome of human.


name: ATX2L_HUMAN Ataxin-2-like protein (sprot)

description: An ataxin-2-like protein that is encoded in the genome of human.


NIGERICIN

A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.


LMNA_HUMAN Prelamin-A/C (sprot)

A prelamin-A/C that is encoded in the genome of human.


name: KINH_HUMAN Kinesin-1 heavy chain (sprot)

description: A kinesin-1 heavy chain that is encoded in the genome of human.


name: SUMO2_HUMAN Small ubiquitin-related modifier 2 (sprot)

description: A small ubiquitin-related modifier 2 that is encoded in the genome of human.


name: CH60_HUMAN 60 kDa heat shock protein, mitochondrial (sprot)

description: A 60 kDa heat shock protein, mitochondrial that is encoded in the genome of human.


name: HNRPU_HUMAN Heterogeneous nuclear ribonucleoprotein U (sprot)

description: A heterogeneous nuclear ribonucleoprotein U that is encoded in the genome of human.


CMA1_HUMAN Chymase (sprot)

A chymase that is encoded in the genome of human.


name: TM11E_HUMAN Transmembrane protease serine 11E (sprot)

description: A transmembrane protease serine 11E that is encoded in the genome of human.


name: KCNA3_HUMAN Potassium voltage-gated channel subfamily A member 3 (sprot)

description: A voltage-gated potassium channel subunit KCNA3 that is encoded in the genome of human.


name: BNIP3_HUMAN BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (sprot)

description: A BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 that is encoded in the genome of human.


name: ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (sprot)

description: An ADAM 17 endopeptidase that is encoded in the genome of human.


name: K2C1_HUMAN Keratin, type II cytoskeletal 1 (sprot)

description: A keratin, type II cytoskeletal 1 that is encoded in the genome of human.


swine influenza

description: An acute viral respiratory infection caused by a strain of influenza virus which is endemic in swine (pigs). Rarely reported in humans prior to 2009, the disease is caused by a mutated strain of swine influenza A (H1N1) virus. It is highly contagious and spreads mainly through coughing and sneezing. Signs and symptoms include fever, chills, coughing, sore throat headache, muscle ache, and generalized weakness. Antiviral medications are most effective in the first two days of the illness.


BGLR_HUMAN Beta-glucuronidase (sprot)

A beta-glucuronidase that is encoded in the genome of human.


name: KCNH8_HUMAN Potassium voltage-gated channel subfamily H member 8 (sprot)

description: A voltage-gated potassium channel KCNH8 that is encoded in the genome of human.


name: SRSF1_HUMAN Serine/arginine-rich splicing factor 1 (sprot)

description: A splicing factor, arginine/serine-rich 1 that is encoded in the genome of human.


name: RECQ4_HUMAN ATP-dependent DNA helicase Q4 (sprot)

description: An ATP-dependent DNA helicase Q4 that is encoded in the genome of human.


The L-enantiomer of thyroxine.


APOA1_HUMAN Apolipoprotein A-I (sprot)

An apolipoprotein A-I that is encoded in the genome of human.


clonazepam

1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.


name: TPH1_HUMAN Tryptophan 5-hydroxylase 1 (sprot)

description: A tryptophan 5-hydroxylase 1 that is encoded in the genome of human.


ENOG_HUMAN Gamma-enolase (sprot)

A gamma-enolase that is encoded in the genome of human.


paraganglioma

description: A benign or malignant neoplasm arising from paraganglia located along the sympathetic or parasympathetic nerves. Infrequently, it may arise outside the usual distribution of the sympathetic and parasympathetic paraganglia. Tumors arising from the adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas usually display a nesting (Zellballen) growth pattern. There are no reliable morphologic criteria to distinguish between benign and malignant paragangliomas. The only definitive indicator of malignancy is the presence of regional or distant metastases.


name: F16P2_HUMAN Fructose-1,6-bisphosphatase isozyme 2 (sprot)

description: A fructose-1,6-bisphosphatase isozyme 2 that is encoded in the genome of human.


name: sinus histiocytosis with massive lymphadenopathy

description: A rare disorder of unknown etiology characterized by distention of the lymph node sinuses and sinusoidal histiocytic infiltration. The histiocytes characteristically contain ingested lymphocytes. Patients present with cervical lymphadenopathy, fever, leukocytosis, and hypergammaglobulinemia. It can affect extranodal sites, including skin, bones, and the respiratory tract. It usually regresses spontaneously.


name: HAP28_HUMAN 28 kDa heat- and acid-stable phosphoprotein (sprot)

description: A 28 kDa heat- and acid-stable phosphoprotein that is encoded in the genome of human.


name: CGAS_HUMAN Cyclic GMP-AMP synthase (sprot)

description: A protein MB21D1 that is encoded in the genome of human.


name: KRR1_HUMAN KRR1 small subunit processome component homolog (sprot)

description: A KRR1 small subunit processome component that is encoded in the genome of human.


sodium nitrite

An inorganic sodium salt having nitrite as the counterion. Used as a food preservative and antidote to cyanide poisoning.


myopathy

description: A disease of the muscle in which the muscle fibers do not function properly. This results in muscular weakness.


MUC4_HUMAN Mucin-4 (sprot)

A mucin-4 that is encoded in the genome of human.


betulinic acid

A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium claviflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties.


name: RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (sprot)

description: A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human.


name: NCKP1_HUMAN Nck-associated protein 1 (sprot)

description: A Nck-associated protein 1 that is encoded in the genome of human.


pevonedistat

A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine which is substituted by a (1S)-2,3-dihydro-1H-inden-1-ylnitrilo group at position 4 and by a (1S,3S,4S)-3-hydroxy-4-[(sulfamoyloxy)methyl]cyclopentyl group at position 7. It is a potent and selective NEDD8-activating enzyme inhibitor with an IC50 of 4.7 nM, and currently under clinical investigation for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes.


SODIUM NITRATE

The inorganic nitrate salt of sodium.


AGRIN_HUMAN Agrin (sprot)

An agrin that is encoded in the genome of human.


PROK2_HUMAN Prokineticin-2 (sprot)

A prokineticin-2 that is encoded in the genome of human.


GALA_HUMAN Galanin peptides (sprot)

A galanin that is encoded in the genome of human.


harmine

A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7.


name: MEF2D_HUMAN Myocyte-specific enhancer factor 2D (sprot)

description: A myocyte-specific enhancer factor 2D that is encoded in the genome of human.


name: NR0B2_HUMAN Nuclear receptor subfamily 0 group B member 2 (sprot)

description: A nuclear receptor subfamily 0 group B member 2 that is encoded in the genome of human.


plasma cell myeloma

description: A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)


dimethyl sulfoxide

A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.


glomerular disorder

description: A disease involving the renal glomerulus.


skin disorder

description: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.


Down syndrome

description: Down syndrome is a chromosomal abnormality caused by the presence of a third (partial or total) copy of the chromosome 21 genetic material and that is characterized by variable intellectual disability, muscular hypotonia, and joint laxity, often associated with a characteristic facial dysmorphism and various anomalies such as cardiac, gastrointestinal, or endocrine defects.


fosaprepitant

A morpholine derivative that is the (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl ether of (3-{[(2R,3S)-3-(4-fluorophenyl)-2-hydroxymorpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid.


name: GPR35_HUMAN G-protein coupled receptor 35 (sprot)

description: A G-protein coupled receptor 35 that is encoded in the genome of human.


ETANIDAZOLE

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitro-1H-imidazol-1-yl)acetic acid with the amino group of ethanolamine. Used as a radiosensitising agent for hypoxic tumour cells.


ANXA2_HUMAN Annexin A2 (sprot)

An annexin A2 that is encoded in the genome of human.


Nocturia

description: Abnormally increased production of urine during the night leading to an unusually frequent need to urinate.


name: RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (sprot)

description: A receptor-interacting serine/threonine-protein kinase 2 that is encoded in the genome of human.


leflunomide

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.


alanyl glutamine

A dipeptide formed from L-alanyl and L-glutamine residues.


obesity disorder

description: A disorder involving an excessive amount of body fat.


name: TMPS2_HUMAN Transmembrane protease serine 2 (sprot)

description: A transmembrane protease serine 2 that is encoded in the genome of human.


perindopril

An alpha-amino acid ester that is the ethyl ester of N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvaline


name: DUX4_HUMAN Double homeobox protein 4 (sprot)

description: A double homeobox protein 4 that is encoded in the genome of human.


FRG1_HUMAN Protein FRG1 (sprot)

A protein FRG1 that is encoded in the genome of human.


bone cancer

description: A primary or metastatic malignant neoplasm affecting the bone or articular cartilage.


Allodynia

description: Pain due to a stimulus that does not normally provoke pain.


neuroblastoma

description: Neuroblastoma (NB) is the most common solid, extracranial childhood tumor. It is an aggressive pediatric cancer that originates from neural crest tissues of the sympathetic nervous system.


Hyponatremia

description: An abnormally decreased sodium concentration in the blood.


renal cell carcinoma

description: A carcinoma that arises from glandular epithelial cells of the kidney


name: RS16_HUMAN Small ribosomal subunit protein uS9 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS9 that is encoded in the genome of human.


name: RS18_HUMAN Small ribosomal subunit protein uS13 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS13 that is encoded in the genome of human.


momelotinib

A benzamide obtained by formal condensation of the carboxy group of 4-{2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl}benzoic acid with the primary amino group of aminoacetonitrile. It is an ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 nM and 18 nM, respectively. Used for the treatment of patients with intermediate- or high-risk myelofibrosis.


name: ACVR1_HUMAN Activin receptor type-1 (sprot)

description: An activin receptor type-1 that is encoded in the genome of human.


MUC2_HUMAN Mucin-2 (sprot)

A mucin-2 that is encoded in the genome of human.


MMP7_HUMAN Matrilysin (sprot)

A matrilysin that is encoded in the genome of human.


name: ZNRF3_HUMAN E3 ubiquitin-protein ligase ZNRF3 (sprot)

description: An E3 ubiquitin-protein ligase ZNRF3 that is encoded in the genome of human.


name: HGF_HUMAN Hepatocyte growth factor (sprot)

description: A hepatocyte growth factor that is encoded in the genome of human.


azathioprine

A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.


SESN2_HUMAN Sestrin-2 (sprot)

A sestrin-2 that is encoded in the genome of human.


name: AKAP1_HUMAN A-kinase anchor protein 1, mitochondrial (sprot)

description: An A-kinase anchor protein 1, mitochondrial that is encoded in the genome of human.


name: SPIR2_HUMAN Protein spire homolog 2 (sprot)

description: A protein spire homolog 2 that is encoded in the genome of human.


adenoviridae infectious disease

description: An infectious process caused by adenovirus. The virus may cause respiratory illness, conjunctivitis, gastroenteritis, and cystitis.


ovarian carcinoma

description: A malignant neoplasm originating from the surface ovarian epithelium. It accounts for the greatest number of deaths from malignancies of the female genital tract and is the fifth leading cause of cancer fatalities in women. It is predominantly a disease of older white women of northern European extraction, but it is seen in all ages and ethnic groups. Adenocarcinomas constitute the vast majority of ovarian carcinomas. The pattern of metastatic spread in ovarian carcinoma is similar regardless of the microscopic type. The most common sites of involvement are the contralateral ovary, peritoneal cavity, para-aortic and pelvic lymph nodes, and liver. Lung and pleura are the most common sites of extra-abdominal spread. The primary form of therapy is surgical. The overall prognosis of ovarian carcinoma remains poor, a direct result of its rapid growth rate and the lack of early symptoms. --2002


name: IRAK1_HUMAN Interleukin-1 receptor-associated kinase 1 (sprot)

description: An interleukin-1 receptor-associated kinase 1 that is encoded in the genome of human.


name: TRXR2_HUMAN Thioredoxin reductase 2, mitochondrial (sprot)

description: A thioredoxin reductase 2, mitochondrial that is encoded in the genome of human.


name: DAPK2_HUMAN Death-associated protein kinase 2 (sprot)

description: A death-associated protein kinase 2 that is encoded in the genome of human.


name: CDKN3_HUMAN Cyclin-dependent kinase inhibitor 3 (sprot)

description: A cyclin-dependent kinase inhibitor 3 that is encoded in the genome of human.


name: ATRX_HUMAN Transcriptional regulator ATRX (sprot)

description: A transcriptional regulator ATRX that is encoded in the genome of human.


ARRB1_HUMAN Beta-arrestin-1 (sprot)

A beta-arrestin-1 that is encoded in the genome of human.


name: NOTC3_HUMAN Neurogenic locus notch homolog protein 3 (sprot)

description: A neurogenic locus notch homolog protein 3 that is encoded in the genome of human.


name: HDAC3_HUMAN Histone deacetylase 3 (sprot)

description: A histone deacetylase 3 that is encoded in the genome of human.


midostaurin

An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine.


name: KPCB_HUMAN Protein kinase C beta type (sprot)

description: A protein kinase C beta type that is encoded in the genome of human.


gingerol

A beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger.


dobutamine

A  catecholamine that is 4-(3-aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used as the hydrochloride to increase the contractility of the heart in the management of acute heart failure.


Hypovolemia

description: An decrease in the amount of intravascular fluid, particularly in the volume of the circulating blood.


Evans syndrome

description: Evans syndrome is a rare chronic hematologic disorder characterized by the simultaneous or sequential association of autoimmune hemolytic anemia (AIHA; a disorder in which auto-antibodies are directed against red blood cells causing anemia of varying degrees of severity) with immune thrombocytopenic purpura (ITP; a coagulation disorder in which auto-antibodies are directed against platelets causing hemorrhagic episodes) and occasionally autoimmune neutropenia, in the absence of a known underlying etiology.


ICOSL_HUMAN ICOS ligand (sprot)

An ICOS ligand that is encoded in the genome of human.


squamous cell lung carcinoma

description: A carcinoma arising from squamous bronchial epithelial cells. It may be keratinizing or non-keratinizing. Keratinizing squamous cell carcinoma is characterized by the presence of keratinization, pearl formation, and/or intercellular bridges. Non-keratinizing squamous cell carcinoma is characterized by the absence of keratinization, pearl formation, and intercellular bridges. Cigarette smoking and arsenic exposure are strongly associated with squamous cell lung carcinoma.


pyoderma gangrenosum

description: Pyoderma gangrenosum (PG) is a primarily sterile inflammatory neutrophilic dermatosis characterized by recurrent cutaneous ulcerations with a mucopurulent or hemorrhagic exudate.


ritonavir

An L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.


hypercalcemia disease

description: Abnormally high concentration of calcium in the peripheral blood.


CYTSB_HUMAN Cytospin-B (sprot)

A cytospin-B that is encoded in the genome of human.


name: HDAC2_HUMAN Histone deacetylase 2 (sprot)

description: A histone deacetylase 2 that is encoded in the genome of human.


periodontitis

description: An acute or chronic inflammatory process that affects the tissues that surround and support the teeth.


name: TRAF4_HUMAN TNF receptor-associated factor 4 (sprot)

description: A TNF receptor-associated factor 4 that is encoded in the genome of human.


name: postural orthostatic tachycardia syndrome

description: A condition characterized by development of symptoms while standing. It is an autonomic nervous system disorder and the symptoms are relieved once the person sits back down. Symptoms include heart.


mitoxantrone

A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.


name: NEC1_HUMAN Neuroendocrine convertase 1 (sprot)

description: A neuroendocrine convertase 1 that is encoded in the genome of human.


thrombocytopenia

description: A laboratory test result indicating that there is an abnormally small number of platelets in the circulating blood.


name: CD28_HUMAN T-cell-specific surface glycoprotein CD28 (sprot)

description: A T-cell-specific surface glycoprotein CD28 that is encoded in the genome of human.


Myotonia

description: An involuntary and painless delay in the relaxation of skeletal muscle following contraction or electrical stimulation.


myocardial ischemia

description: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (coronary artery disease), to obstruction by a thrombus (coronary thrombosis), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (myocardial infarction).


dapsone

A  sulfone that is diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide  range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy.


liver failure

description: A liver disease characterized by the liver losing or has lost all of its function.


ARGI1_HUMAN Arginase-1 (sprot)

An arginase-1 that is encoded in the genome of human.


ANXA1_HUMAN Annexin A1 (sprot)

An annexin A1 that is encoded in the genome of human.


ATRAZINE

A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.


rosacea

description: A chronic erythematous skin disorder that affects the face. It is characterized by the development of redness in the cheeks, nose, and/or forehead and telangiectasia. Sometimes, the erythematous changes may involve the eyelids.


acetic acid

A simple monocarboxylic acid containing two carbons.


LEG3_HUMAN Galectin-3 (sprot)

A galectin-3 that is encoded in the genome of human.


name: MAGA3_HUMAN Melanoma-associated antigen 3 (sprot)

description: A melanoma-associated antigen 3 that is encoded in the genome of human.


PTN_HUMAN Pleiotrophin (sprot)

A pleiotrophin that is encoded in the genome of human.


name: DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (sprot)

description: A DNA (cytosine-5)-methyltransferase 3B that is encoded in the genome of human.


OCLN_HUMAN Occludin (sprot)

An occludin that is encoded in the genome of human.


name: TNR5_HUMAN Tumor necrosis factor receptor superfamily member 5 (sprot)

description: A tumor necrosis factor receptor superfamily member 5 that is encoded in the genome of human.


name: SCRB1_HUMAN Scavenger receptor class B member 1 (sprot)

description: A scavenger receptor class B member 1 that is encoded in the genome of human.


nandrolone

A 3-oxo Delta(4)-steroid that is estr-4-en-3-one substituted by a beta-hydroxy group at position 17.


FZD5_HUMAN Frizzled-5 (sprot)

A frizzled-5 that is encoded in the genome of human.


glutathione

A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.


triple-negative breast carcinoma

description: An invasive breast carcinoma which is negative for expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).


phosphatidylserine (16:0/20:4)

A phosphatidylserine 36:4 in which the acyl group at C-1 contains 16 carbons and no double bonds while that at C-2 contains 20 carbons and 4 double bonds.


A butanediol compound having two hydroxy groups in the 1- and 3-positions.


Edema

description: An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.


S10A8_HUMAN Protein S100-A8 (sprot)

A protein S100-A8 that is encoded in the genome of human.


name: NLRP1_HUMAN NACHT, LRR and PYD domains-containing protein 1 (sprot)

description: A NACHT, LRR and PYD domains-containing protein 1 that is encoded in the genome of human.


neratinib

A quinoline compound having a cyano group at the 3-position, a 3-chloro-4-(2-pyridylmethoxy)anilino group at the 4-position, a 4-dimethylamino-trans-but-2-enoylamido group at the 6-position, and an ethoxy group at the 7-position.


name: PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (sprot)

description: A serine/threonine-protein kinase PAK 1 that is encoded in the genome of human.


atrial fibrillation

description: A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)


bezafibrate

A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.


Impaired glucose tolerance

description: An abnormal resistance to glucose, i.e., a reduction in the ability to maintain glucose levels in the blood stream within normal limits following oral or intravenous administration of glucose.


RNAS4_HUMAN Ribonuclease 4 (sprot)

A ribonuclease 4 that is encoded in the genome of human.


acetohexamide

An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a p-acetylphenylsulfonyl group, while a hydrogen attached to the other nitrogen is replaced by a cyclohexyl group.


PAXI_HUMAN Paxillin (sprot)

A paxillin that is encoded in the genome of human.


trimethylamine N-oxide

A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.


Renal interstitial fibrosis

description: The accumulation of collagen and related extracellular matrix (ECM) molecules in the interstitium of the kidney. The interstitium is expanded by the presence of collagen that stain blue on trichrome. Tubules are not back to back, but rather separated by fibrosis and can be atrophic.


vorinostat

A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and  hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).


NIBA2_HUMAN Protein Niban 2 (sprot)

A protein Niban 2 that is encoded in the genome of human.


name: KAT5_HUMAN Histone acetyltransferase KAT5 (sprot)

description: A histone acetyltransferase KAT5 that is encoded in the genome of human.


name: TIF1B_HUMAN Transcription intermediary factor 1-beta (sprot)

description: A transcription intermediary factor 1-beta that is encoded in the genome of human.


KPYM_HUMAN Pyruvate kinase PKM (sprot)

A pyruvate kinase PKM that is encoded in the genome of human.


Left ventricular hypertrophy

description: Enlargement or increased size of the heart left ventricle.


Sudden death

description: Rapid and unexpected death.


glioblastoma

description: The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)


TENA_HUMAN Tenascin (sprot)

A tenascin that is encoded in the genome of human.


TENX_HUMAN Tenascin-X (sprot)

A tenascin-X that is encoded in the genome of human.


name: PGRC1_HUMAN Membrane-associated progesterone receptor component 1 (sprot)

description: A membrane-associated progesterone receptor component 1 that is encoded in the genome of human.


name: ACSL4_HUMAN Long-chain-fatty-acid--CoA ligase 4 (sprot)

description: A long-chain-fatty-acid--CoA ligase 4 that is encoded in the genome of human.


name: FBX32_HUMAN F-box only protein 32 (sprot)

description: An F-box only protein 32 that is encoded in the genome of human.


name: ECE1_HUMAN Endothelin-converting enzyme 1 (sprot)

description: An endothelin-converting enzyme 1 that is encoded in the genome of human.


name: SOX17_HUMAN Transcription factor SOX-17 (sprot)

description: A transcription factor SOX-17 that is encoded in the genome of human.


name: RL23A_HUMAN Large ribosomal subunit protein uL23 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL23 that is encoded in the genome of human.


name: CXA1_HUMAN Gap junction alpha-1 protein (sprot)

description: A gap junction alpha-1 protein that is encoded in the genome of human.


name: VCAM1_HUMAN Vascular cell adhesion protein 1 (sprot)

description: A vascular cell adhesion protein 1 that is encoded in the genome of human.


cardiomyopathy

description: A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.


major depressive disorder

description: An episode of depression lasting two or more weeks without an intervening episode of mania.


name: HPPD_HUMAN 4-hydroxyphenylpyruvate dioxygenase (sprot)

description: A 4-hydroxyphenylpyruvate dioxygenase that is encoded in the genome of human.


FOSB_HUMAN Protein FosB (sprot)

A protein FosB that is encoded in the genome of human.


kaempferol

A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.


CHIT1_HUMAN Chitotriosidase-1 (sprot)

A chitotriosidase-1 that is encoded in the genome of human.


CP2E1_HUMAN Cytochrome P450 2E1 (sprot)

A cytochrome P450 2E1 that is encoded in the genome of human.


name: FOXA2_HUMAN Hepatocyte nuclear factor 3-beta (sprot)

description: A hepatocyte nuclear factor 3-beta that is encoded in the genome of human.


lomustine

An N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in the treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours.


lymphoma

description: A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas.


name: NR2C2_HUMAN Nuclear receptor subfamily 2 group C member 2 (sprot)

description: A nuclear receptor subfamily 2 group C member 2 that is encoded in the genome of human.


name: TGFB2_HUMAN Transforming growth factor beta-2 proprotein (sprot)

description: A TGF-beta 2 that is encoded in the genome of human.


THEANINE

A N(5)-alkylglutamine where the alkyl group is ethyl. It has been isolated from green tea.


CSTN3_HUMAN Calsyntenin-3 (sprot)

A calsyntenin-3 that is encoded in the genome of human.


name: NFAT5_HUMAN Nuclear factor of activated T-cells 5 (sprot)

description: A nuclear factor of activated T-cells 5 that is encoded in the genome of human.


RBTN1_HUMAN Rhombotin-1 (sprot)

A rhombotin-1 that is encoded in the genome of human.


name: REG3A_HUMAN Regenerating islet-derived protein 3-alpha (sprot)

description: A regenerating islet-derived protein 3-alpha that is encoded in the genome of human.


sodium lauryl sulfate

An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.


name: TXNL1_HUMAN Thioredoxin-like protein 1 (sprot)

description: A thioredoxin-like protein 1 that is encoded in the genome of human.


Hyposmia

description: A decreased sensitivity to odorants (that is, a decreased ability to perceive odors).


renal cell adenocarcinoma

description: A carcinoma arising from the renal parenchyma. There is a strong correlation between cigarette smoking and the development of renal cell carcinoma. The clinical presentation includes : hematuria, flank pain and a palpable lumbar mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound is performed for other purposes. Radical nephrectomy is the standard intervention procedure. Renal cell carcinoma is generally considered to be resistant to radiation treatment and chemotherapy.


macrogol

A 1,2-glycol compound produced via reaction of ethylene oxide with water.


CATECHOL

A  benzenediol comprising of a benzene core carrying two hydroxy substituents ortho to each other.


name: CDK16_HUMAN Cyclin-dependent kinase 16 (sprot)

description: A cyclin-dependent kinase 16 that is encoded in the genome of human.


ezetimibe

A beta-lactam that is azetidin-2-one which is substituted at 1, 3, and 4 by p-fluorophenyl, 3-(p-fluorophenyl)-3-hydroxypropyl, and  4-hydroxyphenyl groups, respectively (the 3R,3'S,4S enantiomer).


NR1H4_HUMAN Bile acid receptor (sprot)

A bile acid receptor that is encoded in the genome of human.


name: UBA3_HUMAN NEDD8-activating enzyme E1 catalytic subunit (sprot)

description: A NEDD8-activating enzyme E1 catalytic subunit that is encoded in the genome of human.


name: APC15_HUMAN Anaphase-promoting complex subunit 15 (sprot)

description: An anaphase-promoting complex subunit 15 that is encoded in the genome of human.


name: HTRA2_HUMAN Serine protease HTRA2, mitochondrial (sprot)

description: A serine protease HTRA2, mitochondrial that is encoded in the genome of human.


name: DPPA4_HUMAN Developmental pluripotency-associated protein 4 (sprot)

description: A developmental pluripotency-associated protein 4 that is encoded in the genome of human.


name: DPPA2_HUMAN Developmental pluripotency-associated protein 2 (sprot)

description: A developmental pluripotency-associated protein 2 that is encoded in the genome of human.


name: SF3B1_HUMAN Splicing factor 3B subunit 1 (sprot)

description: A splicing factor 3B subunit 1 that is encoded in the genome of human.


name: PRKN_HUMAN E3 ubiquitin-protein ligase parkin (sprot)

description: An E3 ubiquitin-protein ligase parkin that is encoded in the genome of human.


name: GLIS1_HUMAN Zinc finger protein GLIS1 (sprot)

description: A zinc finger protein GLIS1 that is encoded in the genome of human.


protein CASP isoform CASP (human)

A protein CASP isoform CASP that is encoded in the genome of human.


name: TGFR2_HUMAN TGF-beta receptor type-2 (sprot)

description: A TGF-beta receptor type-2 that is encoded in the genome of human.


glycine

The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.


name: KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (sprot)

description: A calcium/calmodulin-dependent protein kinase type II subunit alpha that is encoded in the genome of human.


name: BHE41_HUMAN Class E basic helix-loop-helix protein 41 (sprot)

description: A class E basic helix-loop-helix protein 41 that is encoded in the genome of human.


paracetamol

A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.


name: HDHD2_HUMAN Haloacid dehalogenase-like hydrolase domain-containing protein 2 (sprot)

description: A haloacid dehalogenase-like hydrolase domain-containing protein 2 that is encoded in the genome of human.


phosphatidylcholine (18:1/22:2)

A phosphatidylcholine 40:3 in which the fatty acyl groups at positions 1 and 2 are specified as C18:1 and C22:2 respectively.


(S)-fotemustine

A diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate that has S configuration.


name: GBRL2_HUMAN Gamma-aminobutyric acid receptor-associated protein-like 2 (sprot)

description: A gamma-aminobutyric acid receptor-associated protein-like 2 that is encoded in the genome of human.


CHLOROLITHIUM

A metal chloride salt with a Li(+) counterion.


methamphetamine

A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.


fulvestrant

A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.


name: ANPRB_HUMAN Atrial natriuretic peptide receptor 2 (sprot)

description: An atrial natriuretic peptide receptor 2 that is encoded in the genome of human.


CHARCOAL, ACTIVATED

An allotropic form of the element carbon with cubic structure which is thermodynamically stable at pressures above 6 GPa at room temperature and metastable at atmospheric pressure. At low pressures diamond converts rapidly to graphite at temperatures above 1900 K in an inert atmosphere. The chemical bonding between the carbon atoms is covalent with sp(3) hybridization.


microinvasive gastric cancer

description: An invasive adenocarcinoma confined to the mucosa or mucosa and submucosa of the gastric wall. The regional lymph nodes may or may not be involved. It usually occurs in the lesser curvature. The 5-year survival rate following resection is between 80 percent and 95 percent, and remains high even when lymph node metastases are present.


CP1B1_HUMAN Cytochrome P450 1B1 (sprot)

A cytochrome P450 1B1 that is encoded in the genome of human.


CCNA2_HUMAN Cyclin-A2 (sprot)

A cyclin-A2 that is encoded in the genome of human.


stroke disorder

description: A sudden loss of neurological function secondary to hemorrhage or ischemia in the brain parenchyma due to a vascular event.


RTN4_HUMAN Reticulon-4 (sprot)

A reticulon-4 that is encoded in the genome of human.


geraniol

A monoterpenoid consisting of two prenyl units linked head-to-tail and functionalised with a hydroxy group at its tail end.


Ewing sarcoma of bone

description: A small round cell bone tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal tumor. It often affects the diaphysis or metaphyseal-diaphyseal portion of long bones. Clinical findings include pain and a mass in the involved area. fever, anemia, leukocytosis, and an increased sedimentation rate are often seen. X-ray examination reveals osteolytic lesions. The prognosis depends on the stage, anatomic location, and size of the tumor.


congestive heart failure

description: Failure of the heart to pump a sufficient amount of blood to meet the needs of the body tissues, resulting in tissue congestion and edema. Signs and symptoms include shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales.


A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.


name: IKKA_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit alpha (sprot)

description: An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of human.


adrenocortical insufficiency

description: An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency).


endometrial cancer

description: Primary or metastatic malignant neoplasm involving the endometrium (mucous membrane that lines the endometrial cavity).


perfluorooctanoic acid

A fluoroalkanoic acid that is perfluorinated octanoic acid.


name: NTCP_HUMAN Hepatic sodium/bile acid cotransporter (sprot)

description: A hepatic sodium/bile acid cotransporter that is encoded in the genome of human.


bepridil

A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.


name: ABCC9_HUMAN ATP-binding cassette sub-family C member 9 (sprot)

description: An ATP-binding cassette sub-family C member 9 that is encoded in the genome of human.


aldehydo-L-rhamnose

The acyclic form of L-rhamnose.


name: TMM26_HUMAN Transmembrane protein 26 (sprot)

description: A transmembrane protein 26 that is encoded in the genome of human.


name: HXB1_HUMAN Homeobox protein Hox-B1 (sprot)

description: A homeobox protein Hox-B1 that is encoded in the genome of human.


mocetinostat

A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).


EPA

An icosapentaenoic acid having five cis-double bonds at positions 5, 8, 11, 14 and 17.


name: HS71B_HUMAN Heat shock 70 kDa protein 1B (sprot)

description: A heat shock 70 kDa protein 1B that is encoded in the genome of human.


name: PCKGM_HUMAN Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (sprot)

description: A phosphoenolpyruvate carboxykinase [GTP], mitochondrial that is encoded in the genome of human.


name: E2F7_HUMAN Transcription factor E2F7 (sprot)

description: A transcription factor E2F7 that is encoded in the genome of human.


allopurinol

A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.


nephrogenic diabetes insipidus

description: Nephrogenic diabetes insipidus (NDI) is characterized by polyuria with polydipsia, recurrent bouts of fever, constipation, and acute hypernatremic dehydration after birth that may cause neurological sequelae. Polyuria may exceed 10 liters in children.


nicotinamide

A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.


name: HSP74_HUMAN Heat shock 70 kDa protein 4 (sprot)

description: A heat shock 70 kDa protein 4 that is encoded in the genome of human.


name: JIP4_HUMAN C-Jun-amino-terminal kinase-interacting protein 4 (sprot)

description: A C-Jun-amino-terminal kinase-interacting protein 4 that is encoded in the genome of human.


prolymphocytic leukemia

description: A mature B- or T- cell leukemia with progressive clinical course. It is characterized by the presence of medium-sized lymphocytes with visible nucleoli (prolymphocytes) in the peripheral blood, bone marrow, and spleen.


name: LHX2_HUMAN LIM/homeobox protein Lhx2 (sprot)

description: A LIM/homeobox protein Lhx2 that is encoded in the genome of human.


name: GBX2_HUMAN Homeobox protein GBX-2 (sprot)

description: A homeobox protein GBX-2 that is encoded in the genome of human.


name: S12A2_HUMAN Solute carrier family 12 member 2 (sprot)

description: A solute carrier family 12 member 2 that is encoded in the genome of human.


name: LAT_HUMAN Linker for activation of T-cells family member 1 (sprot)

description: A linker for activation of T-cells family member 1 that is encoded in the genome of human.


name: ATS14_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 14 (sprot)

description: An a disintegrin and metalloproteinase with thrombospondin motifs 14 that is encoded in the genome of human.


methylphenidate

A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.


SOST_HUMAN Sclerostin (sprot)

A sclerostin that is encoded in the genome of human.


(S)-BICALUTAMIDE

A N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide that is the (S)-enantiomer of bicalutamide.


An alpha-(1,6)-fucosyltransferase that is encoded in the genome of human.


name: FABP4_HUMAN Fatty acid-binding protein, adipocyte (sprot)

description: A fatty acid-binding protein, adipocyte that is encoded in the genome of human.


name: HXA5_HUMAN Homeobox protein Hox-A5 (sprot)

description: A homeobox protein Hox-A5 that is encoded in the genome of human.


cefotiam

A cephalosporin with ({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl and (2-amino-1,3-thiazol-4-yl)acetamido substituents at positions 3 and 7, respectively, of the cephem skeleton. A third generation beta-lactam cephalosporin antibiotic, it is active against a broad spectrum of both Gram positive and Gram negative bacteria.


DEOXYNIVALENOL

A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.


name: CD36_HUMAN Platelet glycoprotein 4 (sprot)

description: A platelet glycoprotein 4 that is encoded in the genome of human.


name: RHG01_HUMAN Rho GTPase-activating protein 1 (sprot)

description: A Rho GTPase-activating protein 1 that is encoded in the genome of human.


name: CCNB1_HUMAN G2/mitotic-specific cyclin-B1 (sprot)

description: A G2/mitotic-specific cyclin-B1 that is encoded in the genome of human.


cyproheptadine

The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.


SMS_HUMAN Somatostatin (sprot)

A somatostatin that is encoded in the genome of human.


name: WWOX_HUMAN WW domain-containing oxidoreductase (sprot)

description: A WW domain-containing oxidoreductase that is encoded in the genome of human.


name: PI2R_HUMAN Prostacyclin receptor (sprot)

description: A prostacyclin receptor that is encoded in the genome of human.


trazodone

An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.


name: PAK3_HUMAN Serine/threonine-protein kinase PAK 3 (sprot)

description: A serine/threonine-protein kinase PAK 3 that is encoded in the genome of human.


recurrent hypersomnia

description: Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., idiopathic hypersomnolence; narcolepsy; and kleine-levin syndrome) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, mental disorders, and sleep apnea syndrome). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)


name: ARL2_HUMAN ADP-ribosylation factor-like protein 2 (sprot)

description: An ADP-ribosylation factor-like protein 2 that is encoded in the genome of human.


rubitecan

A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.


FILA_HUMAN Filaggrin (sprot)

A filaggrin that is encoded in the genome of human.


name: hematopoietic and lymphoid system neoplasm

description: Neoplasms of the hematopoietic system, including hematopoietic cell neoplasms (e.g. leukemias, lymphomas) and non-hematopoietic cell neoplasms that can affect the hematopoietic system (e.g. lymph node and splenic sarcomas). --2003


carcinoma

description: A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas.


name: LTC4S_HUMAN Leukotriene C4 synthase (sprot)

description: A leukotriene C4 synthase that is encoded in the genome of human.


name: MIB1_HUMAN E3 ubiquitin-protein ligase MIB1 (sprot)

description: An E3 ubiquitin-protein ligase MIB1 that is encoded in the genome of human.


TFG_HUMAN Protein TFG (sprot)

A protein TFG that is encoded in the genome of human.


Azotemia

description: An increased concentration of nitrogen compounds in the blood.


name: BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (sprot)

description: A baculoviral IAP repeat-containing protein 2 that is encoded in the genome of human.


edaravone

A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.


name: ISL1_HUMAN Insulin gene enhancer protein ISL-1 (sprot)

description: An insulin gene enhancer protein ISL-1 that is encoded in the genome of human.


name: RHG36_HUMAN Rho GTPase-activating protein 36 (sprot)

description: A Rho GTPase-activating protein 36 that is encoded in the genome of human.


A member of the class of biindoles that is indirubin substituted at position 6 by a bromo group and in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime.


name: SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (sprot)

description: An NAD-dependent protein deacetylase sirtuin-1 that is encoded in the genome of human.


CP4Z1_HUMAN Cytochrome P450 4Z1 (sprot)

A cytochrome P450 4Z1 that is encoded in the genome of human.


name: CDK3_HUMAN Cyclin-dependent kinase 3 (sprot)

description: A cyclin-dependent kinase 3 that is encoded in the genome of human.


DEF6_HUMAN Defensin-6 (sprot)

A protein that is a translation product of the DEFA6 gene in human.


name: DEFI6_HUMAN Differentially expressed in FDCP 6 homolog (sprot)

description: A differentially expressed in FDCP 6 that is encoded in the genome of human.


cefaloridine

A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C.


name: S22A5_HUMAN Organic cation/carnitine transporter 2 (sprot)

description: An organic cation/carnitine transporter 2 that is encoded in the genome of human.


FBLN5_HUMAN Fibulin-5 (sprot)

A fibulin-5 that is encoded in the genome of human.


pyridoxine

A hydroxymethylpyridine with hydroxymethyl groups at positions 4 and 5, a hydroxy group at position 3 and a methyl group at position 2. The 4-methanol form of vitamin B6, it is converted intoto pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid.


oxaliplatin

A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.


name: TNR1B_HUMAN Tumor necrosis factor receptor superfamily member 1B (sprot)

description: A tumor necrosis factor receptor superfamily member 1B that is encoded in the genome of human.


name: MLH3_HUMAN DNA mismatch repair protein Mlh3 (sprot)

description: A DNA mismatch repair protein Mlh3 that is encoded in the genome of human.


name: HORM1_HUMAN HORMA domain-containing protein 1 (sprot)

description: A HORMA domain-containing protein 1 that is encoded in the genome of human.


name: PDE1A_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (sprot)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A that is encoded in the genome of human.


diazepam

A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.


Neurodevelopmental delay

description: Neurodevelopmental delay (NDD) refers to delays in the maturation of the brain and central nervous system; infants and young children with NDD may experience delays in the development of one or more skills including gross motor abilities, fine-motor coordination, language abilities and ability to solve increasingly complex problems.


RYR1_HUMAN Ryanodine receptor 1 (sprot)

A ryanodine receptor 1 that is encoded in the genome of human.


name: NRG1_HUMAN Pro-neuregulin-1, membrane-bound isoform (sprot)

description: A pro-neuregulin-1, membrane-bound isoform that is encoded in the genome of human.


IL37_HUMAN Interleukin-37 (sprot)

An interleukin-37 that is encoded in the genome of human.


CREATININE

A lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine.


diabetic ketoacidosis

description: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.


oppositional defiant disorder

description: A behavior disorder characterized by a persistent pattern of defiant, disobedient, and hostile behavior towards authority figures, manifested by a frequent loss of temper, arguing, becoming angry or vindictive, or other negativistic behaviors.


paroxetine

A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.


clofazimine

3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of  multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.


chloride

A halide anion formed when chlorine picks up an electron to form an an anion.


name: MET_HUMAN Hepatocyte growth factor receptor (sprot)

description: A hepatocyte growth factor receptor that is encoded in the genome of human.


name: UD18_HUMAN UDP-glucuronosyltransferase 1A8 (sprot)

description: A UDP-glucuronosyltransferase 1A8 that is encoded in the genome of human.


name: ROS1_HUMAN Proto-oncogene tyrosine-protein kinase ROS (sprot)

description: A proto-oncogene tyrosine-protein kinase ROS that is encoded in the genome of human.


baicalein

A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.


name: PARK7_HUMAN Parkinson disease protein 7 (sprot)

description: A parkinson disease protein 7 that is encoded in the genome of human.


name: U2AF2_HUMAN Splicing factor U2AF 65 kDa subunit (sprot)

description: A splicing factor U2AF 65 kDa subunit that is encoded in the genome of human.


name: TFDP1_HUMAN Transcription factor Dp-1 (sprot)

description: A transcription factor Dp-1 that is encoded in the genome of human.


urea

A carbonyl group with two C-bound amine groups. The commercially available fertilizer has an analysis of 46-0-0 (N-P2O5-K2O).


APOB_HUMAN Apolipoprotein B-100 (sprot)

An apolipoprotein B-100 that is encoded in the genome of human.


azilsartan medoxomil

A carboxylic ester obtained by formal condensation of the carboxy group of azilsartan with the hydroxy group of 4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one. A prodrug for azilsartan, it is used for treatment of hypertension.


bronchopulmonary dysplasia

description: Bronchopulmonary dysplasia is a chronic respiratory disease that results from complications related to lung injury during the treatment of infant acute respiratory distress syndrome in low-birth-weight premature infants or from abnormal lung development in older infants. Clinical signs are tachypnea, tachycardia and signs of respiratory distress such as intercostal recession, grunting and nasal flaring.


name: PAX6_HUMAN Paired box protein Pax-6 (sprot)

description: A paired box protein Pax-6 that is encoded in the genome of human.


name: MITF_HUMAN Microphthalmia-associated transcription factor (sprot)

description: A microphthalmia-associated transcription factor that is encoded in the genome of human.


guanidoacetic acid

The N-amidino derivative of glycine.


name: HDA10_HUMAN Polyamine deacetylase HDAC10 (sprot)

description: A polyamine deacetylase HDAC10 that is encoded in the genome of human.


name: INO1_HUMAN Inositol-3-phosphate synthase 1 (sprot)

description: An inositol-3-phosphate synthase 1 that is encoded in the genome of human.


name: TRAM1_HUMAN Translocating chain-associated membrane protein 1 (sprot)

description: A translocation-associated membrane protein 1 that is encoded in the genome of human.


XCL1_HUMAN Lymphotactin (sprot)

A lymphotactin that is encoded in the genome of human.


formalin

An aldehyde resulting from the formal oxidation of methanol.


name: CCL3_HUMAN C-C motif chemokine 3 (sprot)

description: A C-C motif chemokine 3 that is encoded in the genome of human.


name: Bcl-2-binding component 3 isoform 2 (human)

description: A Bcl-2-binding component 3 isoform 2 that is encoded in the genome of human.


name: MAPK2_HUMAN MAP kinase-activated protein kinase 2 (sprot)

description: A MAP kinase-activated protein kinase 2 that is encoded in the genome of human.


dabrafenib

An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma.


epigallocatechin

A flavan-3,3',4',5,5',7-hexol having (2R,3R)-configuration.


name: PEBP1_HUMAN Phosphatidylethanolamine-binding protein 1 (sprot)

description: A phosphatidylethanolamine-binding protein 1 that is encoded in the genome of human.


name: HACE1_HUMAN E3 ubiquitin-protein ligase HACE1 (sprot)

description: An E3 ubiquitin-protein ligase HACE1 that is encoded in the genome of human.


name: MYL1_HUMAN Myosin light chain 1/3, skeletal muscle isoform (sprot)

description: A myosin light chain 1/3, skeletal muscle isoform that is encoded in the genome of human.


MYL4_HUMAN Myosin light chain 4 (sprot)

A myosin light chain 4 that is encoded in the genome of human.


NECD_HUMAN Necdin (sprot)

A necdin that is encoded in the genome of human.


name: OPA1_HUMAN Dynamin-like GTPase OPA1, mitochondrial (sprot)

description: A dynamin-like 120 kDa protein, mitochondrial that is encoded in the genome of human.


name: MBD1_HUMAN Methyl-CpG-binding domain protein 1 (sprot)

description: A methyl-CpG-binding domain protein 1 that is encoded in the genome of human.


DPEP3_HUMAN Dipeptidase 3 (sprot)

A dipeptidase 3 that is encoded in the genome of human.


name: HSF1_HUMAN Heat shock factor protein 1 (sprot)

description: A heat shock factor protein 1 that is encoded in the genome of human.


LYRIC_HUMAN Protein LYRIC (sprot)

A protein LYRIC that is encoded in the genome of human.


Hypervolemia

description: An increase in the amount of intravascular fluid, particularly in the volume of the circulating blood.


cobalt atom

A cobalt group element atom that has atomic number 27.


retinal degeneration

description: Degeneration of the retina.


FSCN1_HUMAN Fascin (sprot)

A fascin that is encoded in the genome of human.


name: ASXL1_HUMAN Polycomb group protein ASXL1 (sprot)

description: A Polycomb group protein ASXL1 that is encoded in the genome of human.


name: KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (sprot)

description: A histone-lysine N-methyltransferase 2A that is encoded in the genome of human.


THIO_HUMAN Thioredoxin (sprot)

A thioredoxin that is encoded in the genome of human.


amitriptyline

An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.


small cell lung carcinoma

description: Small cell lung cancer (SCLC) is a highly aggressive malignant neoplasm, accounting for 10-15% of lung cancer cases, characterized byrapid growth, and early metastasis. SCLC usually manifests as a large hilar mass with bulky mediastinal lymphadenopathy presenting clinically with chest pain, persistent cough, dyspnea, wheezing, hoarseness, hemoptysis, loss of appetite, weight loss, and neurological and endocrine paraneoplastic syndromes. SCLC is primarily reported in elderly people with a history of long-term tobacco exposure.


METHYLSELENINIC ACID

An organoselenium compound that is seleninic acid in which the hydrogen attached to selenium is replaced by a methyl group.


name: AK1C3_HUMAN Aldo-keto reductase family 1 member C3 (sprot)

description: An aldo-keto reductase family 1 member C3 that is encoded in the genome of human.


name: RS24_HUMAN Small ribosomal subunit protein eS24 (sprot)

description: A small ribosomal subunit protein eS24 that is encoded in the genome of human.


TARAXEROL

A pentacyclic triterpenoid that is oleanan-3-ol lacking the methyl group at position 14, with an alpha-methyl substituent at position 13 and a double bond between positions 14 and 15.


name: ATNG_HUMAN Sodium/potassium-transporting ATPase subunit gamma (sprot)

description: A sodium/potassium-transporting ATPase subunit gamma that is encoded in the genome of human.


name: ACBG1_HUMAN Long-chain-fatty-acid--CoA ligase ACSBG1 (sprot)

description: A long-chain-fatty-acid--CoA ligase ACSBG1 that is encoded in the genome of human.


name: PDK2_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (sprot)

description: A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial that is encoded in the genome of human.


non-specific interstitial pneumonia

description: Idiopathic interstitial pneumonia characterized by chronic inflammation and fibrosis in the interstitial lung tissue. It includes cases that cannot be classified into one of the other types of idiopathic interstitial pneumonia.


name: NEK2_HUMAN Serine/threonine-protein kinase Nek2 (sprot)

description: A serine/threonine-protein kinase Nek2 that is encoded in the genome of human.


diacylglycerol (16:0/20:1/0:0)

A 1,2-diglyceride in which the fatty acyl groups at positions 1 and 2 are specified as C16:0 and C18:1 respectively.


name: RAB3A_HUMAN Ras-related protein Rab-3A (sprot)

description: A Ras-related protein Rab-3A that is encoded in the genome of human.


name: P85A_HUMAN Phosphatidylinositol 3-kinase regulatory subunit alpha (sprot)

description: A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of human.


cangrelor

A nucleoside triphosphate analogue that is 5'-O-[({[dichloro(phosphono)methyl](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]adenosine carrying additional 2-(methylsulfanyl)ethyl and (3,3,3-trifluoropropyl)sulfanyl substituents at positions N6 and C2 respectively. Used (in the form of its tetrasodium salt) as an intravenous antiplatelet drug that prevents formation of harmful blood clots in the coronary arteries.


acute coronary syndrome

description: Signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction.


mannitol

The D-enantiomer of mannitol.


hexobarbital

A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups.


name: TPM2_HUMAN Tropomyosin beta chain (sprot)

description: A tropomyosin beta chain that is encoded in the genome of human.


name: FSTL1_HUMAN Follistatin-related protein 1 (sprot)

description: A follistatin-related protein 1 that is encoded in the genome of human.


dantrolene

The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.


Hyperkalemia

description: An abnormally increased potassium concentration in the blood.


brain cancer

description: A primary or metastatic malignant neoplasm affecting the brain.


name: ARFG1_HUMAN ADP-ribosylation factor GTPase-activating protein 1 (sprot)

description: An ADP-ribosylation factor GTPase-activating protein 1 that is encoded in the genome of human.