name: EGLN3_HUMAN Prolyl hydroxylase EGLN3 (sprot)

description: A prolyl hydroxylase EGLN3 that is encoded in the genome of human.


LYAM2_HUMAN E-selectin (sprot)

An E-selectin that is encoded in the genome of human.


felodipine

The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.


propanol

The parent member of the class of propan-1-ols that is propane in which a hydrogen of one of the methyl groups is replaced by a hydroxy group.


NTF4_HUMAN Neurotrophin-4 (sprot)

A neurotrophin-4 that is encoded in the genome of human.


Muscle weakness

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Reduced strength of muscles.


name: MP2K3_HUMAN Dual specificity mitogen-activated protein kinase kinase 3 (sprot)

description: A dual specificity mitogen-activated protein kinase kinase 3 that is encoded in the genome of human.


ropivacaine

A piperidinecarboxamide-based amide-type local anaesthetic (amide caine) in which (S)-N-propylpipecolic acid and 2,6-dimethylaniline are combined to form the amide bond.


name: EMP3_HUMAN Epithelial membrane protein 3 (sprot)

description: An epithelial membrane protein 3 that is encoded in the genome of human.


selinexor

A member of the class of triazoles that is 1H-1,2,4-triazole substituted by (1Z)-3-oxo-3-[2-(pyrazin-2-yl)hydrazinyl]prop-1-en-1-yl and 3,5-bis(trifluoromethyl)phenyl groups at positions 1 and 3, respectively. It is a prescription medicine approved for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma.


MYH10_HUMAN Myosin-10 (sprot)

A myosin-10 that is encoded in the genome of human.


name: PAPD5_HUMAN Terminal nucleotidyltransferase 4B (sprot)

description: A terminal nucleotidyltransferase 4B that is encoded in the genome of human.


name: PAPD7_HUMAN Terminal nucleotidyltransferase 4A (sprot)

description: A terminal nucleotidyltransferase 4A that is encoded in the genome of human.


name: GDF11_HUMAN Growth/differentiation factor 11 (sprot)

description: A growth/differentiation factor 11 that is encoded in the genome of human.


NADPH

The reduced form of NADP+; used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.


limbal stem cell deficiency

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A condition characterized by a loss or deficiency of the stem cells in the limbus that are vital for re-population of the corneal epithelium and to the barrier function of the limbus.


name: K1C14_HUMAN Keratin, type I cytoskeletal 14 (sprot)

description: A keratin, type I cytoskeletal 14 that is encoded in the genome of human.


digitonin

A spirostanyl glycoside that is digitogenin in which the 3-hydroxy group is substituted by a beta-D-glucopyranosyl-(1->3)-beta-D-galactopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->3)]-beta-D-glucopyranosyl-(1->4)-beta-D-galactopyranosyl group. It is a steroidal saponin isolated from the foxglove plant, Digitalis purpurea. It is used extensively as a mild non-ionic detergent for extracting proteins from membranes for structure and function studies.


XPO2_HUMAN Exportin-2 (sprot)

An exportin-2 that is encoded in the genome of human.


name: DMBT1_HUMAN Deleted in malignant brain tumors 1 protein (sprot)

description: A deleted in malignant brain tumors 1 protein that is encoded in the genome of human.


BLMH_HUMAN Bleomycin hydrolase (sprot)

A bleomycin hydrolase that is encoded in the genome of human.


MUC16_HUMAN Mucin-16 (sprot)

A mucin-16 that is encoded in the genome of human.


thioctic acid

A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.


paroxysmal nocturnal hemoglobinuria

description: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disorder characterized by corpuscular hemolytic anemia, bone marrow failure and frequent thrombotic events.


corneal edema

description: Hazy, swollen cornea.


name: OFD1_HUMAN Centriole and centriolar satellite protein OFD1 (sprot)

description: A centriole and centriolar satellite protein OFD1 that is encoded in the genome of human.


name: PP6R3_HUMAN Serine/threonine-protein phosphatase 6 regulatory subunit 3 (sprot)

description: A serine/threonine-protein phosphatase 6 regulatory subunit 3 that is encoded in the genome of human.


gastritis

description: Inflammation of the stomach.


Peripheral demyelination

description: A loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.


phosphatidylserine (18:1/22:6)

A phosphatidylserine 40:7 in which the acyl group at C-1 contains 18 carbons and 1 double bond while that at C-2 contains 22 carbons and 6 double bonds.


name: PABP2_HUMAN Polyadenylate-binding protein 2 (sprot)

description: A polyadenylate-binding protein 2 (human), isoforms 1 and 2.


name: CLCA1_HUMAN Calcium-activated chloride channel regulator 1 (sprot)

description: A calcium-activated chloride channel regulator 1 that is encoded in the genome of human.


name: ETV6_HUMAN Transcription factor ETV6 (sprot)

description: A transcription factor ETV6 that is encoded in the genome of human.


name: VPP3_HUMAN V-type proton ATPase 116 kDa subunit a 3 (sprot)

description: A V-type proton ATPase 116 kDa subunit a 3 that is encoded in the genome of human.


name: CEBPA_HUMAN CCAAT/enhancer-binding protein alpha (sprot)

description: A CCAAT/enhancer-binding protein alpha that is encoded in the genome of human.


crenolanib

A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a 8-(4-aminopiperidin-1-yl)quinolin-2-yl group at position 1 and by a (3-methyloxetan-3-yl)methoxy group at position 5. It is an inhibitor of type III tyrosine kinases, PDGFRalpha/beta and FLT3 (IC50 of 11, 3.2, and 4 nM). Currently under clinical development for the treatment of acute myeloid leukemia.


name: CKLF2_HUMAN CKLF-like MARVEL transmembrane domain-containing protein 2 (sprot)

description: A CKLF-like MARVEL transmembrane domain-containing protein 2 that is encoded in the genome of human.


APOL1_HUMAN Apolipoprotein L1 (sprot)

An apolipoprotein L1 that is encoded in the genome of human.


name: LAMA5_HUMAN Laminin subunit alpha-5 (sprot)

description: A laminin subunit alpha-5 that is encoded in the genome of human.


chronic idiopathic urticaria

description: Chronic form of idiopathic urticaria.


name: IRAK3_HUMAN Interleukin-1 receptor-associated kinase 3 (sprot)

description: An interleukin-1 receptor-associated kinase 3 that is encoded in the genome of human.


name: AT2A3_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (sprot)

description: A sarcoplasmic/endoplasmic reticulum calcium ATPase 3 that is encoded in the genome of human.


HYDRANGENOL

A member of the class of dihydroisocoumarins that is 3,4-dihydroisocoumarin substituted by a hydroxy group at position 8 and a 4-hydroxyphenyl group at position 3. It has been isolated from the roots of Scorzonera judaica and exhibits anti-allergic activity.


urinary bladder carcinoma

description: A carcinoma that arises from epithelial cells of the urinary bladder


name: KCMB1_HUMAN Calcium-activated potassium channel subunit beta-1 (sprot)

description: A calcium-activated potassium channel subunit beta-1 that is encoded in the genome of human.


PESC_HUMAN Pescadillo homolog (sprot)

A pescadillo that is encoded in the genome of human.


leiomyosarcoma of the corpus uteri

description: An aggressive malignant smooth muscle neoplasm, arising from the uterine corpus. It is characterized by a proliferation of neoplastic spindle cells.


name: TWST2_HUMAN Twist-related protein 2 (sprot)

description: A twist-related protein 2 that is encoded in the genome of human.


essential thrombocythemia

description: A chronic myeloproliferative neoplasm that involves primarily the megakaryocytic lineage. It is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and episodes of thrombosis and/or hemorrhage. (WHO, 2008)


TNFB_HUMAN Lymphotoxin-alpha (sprot)

A lymphotoxin-alpha that is encoded in the genome of human.


olodaterol

A member of the class of benzoxazine that is 6-hydroxy-1,4-benzoxazin-3-one in which the hydrogen at position 4 is replaced by a (1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl group. Used (as its hydrochloride salt) for long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and/or emphysema.


name: LAG3_HUMAN Lymphocyte activation gene 3 protein (sprot)

description: A lymphocyte activation gene 3 protein that is encoded in the genome of human.


name: SPHK2_HUMAN Sphingosine kinase 2 (sprot)

description: A sphingosine kinase 2 that is encoded in the genome of human.


name: TF65_HUMAN Transcription factor p65 (sprot)

description: A transcription factor p65 that is encoded in the genome of human.


name: RS9_HUMAN Small ribosomal subunit protein uS4 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS4 that is encoded in the genome of human.


name: BCAS1_HUMAN Breast carcinoma-amplified sequence 1 (sprot)

description: A breast carcinoma-amplified sequence 1 that is encoded in the genome of human.


phalloidin

A homodetic bicyclic heptapeptide having a sulfide bridge.


IL34_HUMAN Interleukin-34 (sprot)

An interleukin-34 that is encoded in the genome of human.


mirabegron

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-amino-1,3-thiazol-4-ylacetic acid with the anilino group of (1R)-2-{[2-(4-aminophenyl)ethyl]amino}-1-phenylethanol. Used for the treatment of overactive bladder syndrome.


name: LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2 (sprot)

description: A latent-transforming growth factor beta-binding protein 2 that is encoded in the genome of human.


name: TMPS4_HUMAN Transmembrane protease serine 4 (sprot)

description: A transmembrane protease serine 4 that is encoded in the genome of human.


Polyuria

description: An increased rate of urine production.


name: LAIR1_HUMAN Leukocyte-associated immunoglobulin-like receptor 1 (sprot)

description: A leukocyte-associated immunoglobulin-like receptor 1 that is encoded in the genome of human.


name: MUS81_HUMAN Crossover junction endonuclease MUS81 (sprot)

description: A crossover junction endonuclease MUS81 that is encoded in the genome of human.


name: PSMG1_HUMAN Proteasome assembly chaperone 1 (sprot)

description: A proteasome assembly chaperone 1 that is encoded in the genome of human.


name: BCAR1_HUMAN Breast cancer anti-estrogen resistance protein 1 (sprot)

description: A breast cancer anti-estrogen resistance protein 1 that is encoded in the genome of human.


name: UBE3C_HUMAN Ubiquitin-protein ligase E3C (sprot)

description: A ubiquitin-protein ligase E3C that is encoded in the genome of human.


APTX_HUMAN Aprataxin (sprot)

An aprataxin that is encoded in the genome of human.


NDRG3_HUMAN Protein NDRG3 (sprot)

A protein NDRG3 that is encoded in the genome of human.


name: UBAP2_HUMAN Ubiquitin-associated protein 2 (sprot)

description: A ubiquitin-associated protein 2 that is encoded in the genome of human.


name: TRPM2_HUMAN Transient receptor potential cation channel subfamily M member 2 (sprot)

description: A transient receptor potential cation channel subfamily M member 2 that is encoded in the genome of human.


EGLN_HUMAN Endoglin (sprot)

An endoglin that is encoded in the genome of human.


name: HSP72_HUMAN Heat shock-related 70 kDa protein 2 (sprot)

description: A heat shock-related 70 kDa protein 2 that is encoded in the genome of human.


CUMENE HYDROPEROXIDE

A peroxol that is cumene in which the alpha-hydrogen is replaced by a hydroperoxy group.


name: ARP2_HUMAN Actin-related protein 2 (sprot)

description: An actin-related protein 2 that is encoded in the genome of human.


METFORMIN HYDROCHLORIDE

A hydrochloride resulting from the reaction of metformin with one molar equivalent of hydrogen chloride.


metastatic malignant neoplasm

description: A malignant tumor that has spread from its original (primary) site of growth to another site close to or distant from the primary site.


IL32_HUMAN Interleukin-32 (sprot)

An interleukin-32 that is encoded in the genome of human.


name: TBX1_HUMAN T-box transcription factor TBX1 (sprot)

description: A T-box transcription factor TBX1 that is encoded in the genome of human.


name: LARP6_HUMAN La-related protein 6 (sprot)

description: A La-related protein 6 that is encoded in the genome of human.


name: HXB5_HUMAN Homeobox protein Hox-B5 (sprot)

description: A homeobox protein Hox-B5 that is encoded in the genome of human.


name: PHLP1_HUMAN PH domain leucine-rich repeat-containing protein phosphatase 1 (sprot)

description: A PH domain leucine-rich repeat-containing protein phosphatase that is encoded in the genome of human.


SC5D_HUMAN Lathosterol oxidase (sprot)

A lathosterol oxidase that is encoded in the genome of human.


name: KCNH6_HUMAN Potassium voltage-gated channel subfamily H member 6 (sprot)

description: A voltage-gated potassium channel KCNH6 that is encoded in the genome of human.


name: DUS12_HUMAN Dual specificity protein phosphatase 12 (sprot)

description: A dual specificity protein phosphatase 12 that is encoded in the genome of human.


sarcosine

A N-alkylglycine that is the N-methyl derivative of glycine. It is an intermediate in the metabolic pathway of glycine.


name: LMX1B_HUMAN LIM homeobox transcription factor 1-beta (sprot)

description: A LIM homeobox transcription factor 1-beta that is encoded in the genome of human.


name: ERF1_HUMAN Eukaryotic peptide chain release factor subunit 1 (sprot)

description: A eukaryotic peptide chain release factor subunit 1 that is encoded in the genome of human.


CASP2_HUMAN Caspase-2 (sprot)

A caspase-2 that is encoded in the genome of human.


name: ROCK1_HUMAN Rho-associated protein kinase 1 (sprot)

description: A Rho-associated protein kinase 1 that is encoded in the genome of human.


TLR8_HUMAN Toll-like receptor 8 (sprot)

A Toll-like receptor 8 that is encoded in the genome of human.


H10_HUMAN Histone H1.0 (sprot)

A histone H1.0 that is encoded in the genome of human.


name: AVR2A_HUMAN Activin receptor type-2A (sprot)

description: An activin receptor type-2A that is encoded in the genome of human.


desoximetasone

Dexamethasone in which the hydroxy group at the 17alpha position is substituted by hydrogen. A synthetic corticosteroid with glucocorticoid activity, it is used as an anti-inflammatory and anti-pruritic in the treatment of various skin disorders, including skin allergies and psoriasis.


alogliptin

A piperidine that is 3-methyl-2,4-dioxo-3,4-dihydropyrimidine carrying additional 2-cyanobenzyl and 3-aminopiperidin-1-yl groups at positions 1 and 2 respectively (the R-enantiomer). Used in the form of its benzoate salt for treatment of type 2 diabetes.


name: E2F4_HUMAN Transcription factor E2F4 (sprot)

description: A transcription factor E2F4 that is encoded in the genome of human.


name: GLYM_HUMAN Serine hydroxymethyltransferase, mitochondrial (sprot)

description: A serine hydroxymethyltransferase, mitochondrial that is encoded in the genome of human.


name: ATS1_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 1 (sprot)

description: An a disintegrin and metalloproteinase with thrombospondin motifs 1 that is encoded in the genome of human.


linezolid

An organofluorine compound that consists of 1,3-oxazolidin-2-one bearing an N-3-fluoro-4-(morpholin-4-yl)phenyl group as well as an acetamidomethyl group at position 5. A synthetic antibacterial agent that inhibits bacterial protein synthesis by binding to a site on 23S ribosomal RNA of the 50S subunit and prevents further formation of a functional 70S initiation complex.


name: PO2F2_HUMAN POU domain, class 2, transcription factor 2 (sprot)

description: A POU domain, class 2, transcription factor 2 that is encoded in the genome of human.


lenvatinib

A member of the class of quinolines that is the carboxamide of 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxylic acid. A multi-kinase inhibitor and orphan drug used (as its mesylate salt) for the treatment of various types of thyroid cancer that do not respond to radioiodine.


name: CRTC2_HUMAN CREB-regulated transcription coactivator 2 (sprot)

description: A CREB-regulated transcription coactivator 2 that is encoded in the genome of human.


tiagabine

A piperidinemonocarboxylic acid that is (R)-nipecotic acid in which the hydrogen attached to the nitrogen has been replaced by a 1,1-bis(3-methyl-2-thienyl)but-1-en-4-yl group. A GABA reuptake inhibitor, it is used (generally as the hydrochloride salt) for the treatment of epilepsy.


absence epilepsy

description: Epilepsy characterized by very brief episodes of sudden cessation of activity, usually associated with eye blinking. There is no loss of the muscle tone.


name: FUND1_HUMAN FUN14 domain-containing protein 1 (sprot)

description: A FUN14 domain-containing protein 1 that is encoded in the genome of human.


adrenal cortex adenoma

description: A benign neoplasm that can arise from any of the adrenal cortical layers. It can be associated with the overproduction of glucocorticoids (Cushing's syndrome), androgenic or estrogenic steroids (adrenogenital syndrome), or mineralocorticoids (Conn's syndrome). (Sternberg Diagnostic Surgical Pathology, 3rd ed.)


name: GTSE1_HUMAN G2 and S phase-expressed protein 1 (sprot)

description: A G2 and S phase-expressed protein 1 that is encoded in the genome of human.


name: ARY2_HUMAN Arylamine N-acetyltransferase 2 (sprot)

description: An arylamine N-acetyltransferase 2 that is encoded in the genome of human.


usnic acid

A member of the class of  dibenzofurans that is dibenzo[b,d]furan-1(9bH)-one substituted by acetyl groups at positions 2 and 6, hydroxy groups at positions 3 and 7 and methyl groups at positions 8 and 9b.


name: CCND3_HUMAN G1/S-specific cyclin-D3 (sprot)

description: A G1/S-specific cyclin-D3 that is encoded in the genome of human.


name: KKCC1_HUMAN Calcium/calmodulin-dependent protein kinase kinase 1 (sprot)

description: A calcium/calmodulin-dependent protein kinase kinase 1 that is encoded in the genome of human.


name: NCK1_HUMAN SH2/SH3 adapter protein NCK1 (sprot)

description: An SH2/SH3 adapter protein NCK1 that is encoded in the genome of human.


name: ZCHC7_HUMAN Zinc finger CCHC domain-containing protein 7 (sprot)

description: A zinc finger CCHC domain-containing protein 7 that is encoded in the genome of human.


name: CRLS1_HUMAN Cardiolipin synthase (CMP-forming) (sprot)

description: A CMP-forming cardiolipin synthase that is encoded in the genome of human.


name: FGD5_HUMAN FYVE, RhoGEF and PH domain-containing protein 5 (sprot)

description: A FYVE, RhoGEF and PH domain-containing protein 5 that is encoded in the genome of human.


hydroxycitronellal

The tertiary alcohol arising from addition of water across the C=C double bond of citronellal.


pethidine

A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.


long QT syndrome

description: A condition that is characterized by episodes of fainting (syncope) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are Romano-Ward syndrome (also known as long QT syndrome 1) and Jervell-Lange Nielsen syndrome.


bethanechol

The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.


NIT2_HUMAN Omega-amidase NIT2 (sprot)

An omega-amidase NIT2 that is encoded in the genome of human.


name: TGFA1_HUMAN Transforming growth factor-beta receptor-associated protein 1 (sprot)

description: A transforming growth factor-beta receptor-associated protein 1 that is encoded in the genome of human.


name: VPS8_HUMAN Vacuolar protein sorting-associated protein 8 homolog (sprot)

description: A vacuolar protein sorting-associated protein 8 that is encoded in the genome of human.


name: KLF8_HUMAN Krueppel-like factor 8 (sprot)

description: A krueppel-like factor 8 that is encoded in the genome of human.


name: ANM8_HUMAN Protein arginine N-methyltransferase 8 (sprot)

description: A protein arginine N-methyltransferase 8 that is encoded in the genome of human.


DSG4_HUMAN Desmoglein-4 (sprot)

A desmoglein-4 that is encoded in the genome of human.


name: REG3G_HUMAN Regenerating islet-derived protein 3-gamma (sprot)

description: A protein that is a translation product of the REG3G gene in human.


NEB2_HUMAN Neurabin-2 (sprot)

A neurabin-2 that is encoded in the genome of human.


SPRC_HUMAN SPARC (sprot)

A SPARC protein that is encoded in the genome of human.


IgG4-related mesenteritis

description: Sclerosing mesenteritis (SM) is a rare pathological disease causing inflammation of the adipose tissue of the small bowel mesentery and is commonly associated with abdominal pain, diarrhea, nausea, weight loss, bloating and loss of appetite. The two subforms include mesenteric panniculitis (where inflammation and fatty necrosis are dominant features) and retractile mesenteritis (where fibrosis and retraction dominate).


NGN3_HUMAN Neurogenin-3 (sprot)

A neurogenin-3 that is encoded in the genome of human.


PANTOTHENIC ACID, RACEMIC

A member of the class of pantothenic acids that is an amide formed from pantoic acid and beta-alanine.


muscular dystrophy

description: Muscular dystrophy (MD) refers to a group of more than 30 genetic diseases characterized by progressive weakness and degeneration of the skeletal muscles that control movement. Some forms of MD are seen in newborns, infants or children, while others have late-onset and may not appear until middle age or later. The disorders differ in terms of the distribution and extent of muscle weakness (some forms of MD also affect cardiac muscle), age of onset, rate of progression, and pattern of inheritance. The prognosis for people with MD varies according to the type and progression of the disorder. There is no specific treatment to stop or reverse any form of MD. Treatment is supportive and may include physical therapy, respiratory therapy, speech therapy, orthopedic appliances used for support, corrective orthopedic surgery, and medicationsincluding corticosteroids, anticonvulsants (seizure medications), immunosuppressants, and antibiotics. Some individuals may need assisted ventilation to treat respiratory muscle weaknessor a pacemaker for cardiac (heart)abnormalities.


piperacillin

A penicillin in which the substituent at position 6 of the penam ring is a 2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido group.


Pseudomonas infection

description: Infections with bacteria of the genus pseudomonas.


name: GPX2_HUMAN Glutathione peroxidase 2 (sprot)

description: A glutathione peroxidase 2 that is encoded in the genome of human.


Global developmental delay

description: A delay in the achievement of motor or mental milestones in the domains of development of a child, including motor skills, speech and language, cognitive skills, and social and emotional skills. This term should only be used to describe children younger than five years of age.


panuveitis

description: A disorder characterized by inflammation of the entire uvea which includes the iris, ciliary body, and choroid. Causes include systemic infections, sarcoidosis, and cancers.


TLN1_HUMAN Talin-1 (sprot)

A talin-1 that is encoded in the genome of human.


name: RAC2_HUMAN Ras-related C3 botulinum toxin substrate 2 (sprot)

description: A Ras-related C3 botulinum toxin substrate 2 that is encoded in the genome of human.


chelerythrine

A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.


name: IL1R2_HUMAN Interleukin-1 receptor type 2 (sprot)

description: An interleukin-1 receptor type 2 that is encoded in the genome of human.


name: DRD2_HUMAN D(2) dopamine receptor (sprot)

description: A D(2) dopamine receptor that is encoded in the genome of human.


hepatic veno-occlusive disease

description: Hepatic veno-occlusive disease (hepatic VOD) is a condition resulting from toxic injury to the hepatic sinusoidal capillaries that leads to obstruction of the small hepatic veins.


name: DHI1_HUMAN 11-beta-hydroxysteroid dehydrogenase 1 (sprot)

description: An 11-beta-hydroxysteroid dehydrogenase 1 that is encoded in the genome of human.


name: IAPP_HUMAN Islet amyloid polypeptide (sprot)

description: An islet amyloid polypeptide that is encoded in the genome of human.


A beta-microseminoprotein that is encoded in the genome of human.


rucaparib

A member of the class of azepinoindoles that is 1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one carrying additional 4-[(methylamino)methyl]phenyl and fluoro substituents at positions 2 and 8 respectively. It is an inhibitor of poly (ADP-ribose) polymerase and is used (as the camsylate salt) as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation.


name: ARH40_HUMAN Rho guanine nucleotide exchange factor 40 (sprot)

description: A Rho guanine nucleotide exchange factor 40 that is encoded in the genome of human.


name: TBL1R_HUMAN F-box-like/WD repeat-containing protein TBL1XR1 (sprot)

description: An F-box-like/WD repeat-containing protein TBL1XR1 that is encoded in the genome of human.


nitrofurantoin

An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.


name: COP1_HUMAN E3 ubiquitin-protein ligase COP1 (sprot)

description: An E3 ubiquitin-protein ligase COP1 that is encoded in the genome of human.


MFN1_HUMAN Mitofusin-1 (sprot)

A mitofusin-1 that is encoded in the genome of human.


dexamfetamine

A 1-phenylpropan-2-amine that has S configuration.


name: ARRD3_HUMAN Arrestin domain-containing protein 3 (sprot)

description: An arrestin domain-containing protein 3 that is encoded in the genome of human.


UTER_HUMAN Uteroglobin (sprot)

A uteroglobin that is encoded in the genome of human.


A dinitrotoluene in which the methyl group is ortho to one of the nitro groups and para to the other. It is the most common isomer of dinitrotoluene.


name: LIMC1_HUMAN LIM and calponin homology domains-containing protein 1 (sprot)

description: A LIM and calponin homology domains-containing protein 1 that is encoded in the genome of human.


intracranial hypertension

description: A finding characterized by increased cerebrospinal fluid pressure within the skull.


CLD3_HUMAN Claudin-3 (sprot)

A claudin-3 that is encoded in the genome of human.


name: RGS4_HUMAN Regulator of G-protein signaling 4 (sprot)

description: A regulator of G-protein signaling 4 that is encoded in the genome of human.


name: EVI5_HUMAN Ecotropic viral integration site 5 protein homolog (sprot)

description: An ecotropic viral integration site 5 protein that is encoded in the genome of human.


name: TF2H1_HUMAN General transcription factor IIH subunit 1 (sprot)

description: A general transcription factor IIH subunit 1 that is encoded in the genome of human.


name: PSMD2_HUMAN 26S proteasome non-ATPase regulatory subunit 2 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 2 that is encoded in the genome of human.


BTG3_HUMAN Protein BTG3 (sprot)

A protein BTG3 that is encoded in the genome of human.


sertraline

A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.


oromandibular dystonia

description: Oromandibular dystonia (OMD) is a form of focal dystonia, affecting the lower part of the face and jaws. It is characterized by sustained or repetitive involuntary jaw and tongue movements and facial grimacing caused by involuntary spasms of the masticatory, facial, pharyngeal, lingual, and lip muscles.


name: KPCZ_HUMAN Protein kinase C zeta type (sprot)

description: A protein kinase C zeta type that is encoded in the genome of human.


STX12_HUMAN Syntaxin-12 (sprot)

A syntaxin-12 that is encoded in the genome of human.


gallbladder carcinoma

description: A carcinoma that arises from epithelial cells of the gall bladder


Abnormality of the vasculature

description: An abnormality of the vasculature.


head and neck neoplasm

description: A benign or malignant neoplasm that affects the anatomic structures of the head and neck region. Representative examples of benign neoplasms include salivary gland pleomorphic adenoma and nasal cavity papilloma. Representative examples of malignant neoplasms include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma.


name: MAGC2_HUMAN Melanoma-associated antigen C2 (sprot)

description: A melanoma-associated antigen C2 that is encoded in the genome of human.


name: RAD1_HUMAN Cell cycle checkpoint protein RAD1 (sprot)

description: A cell cycle checkpoint protein RAD1 that is encoded in the genome of human.


neoplastic meningitis

description: Metastatic neoplasm in which the tumor cells spread to leptomeninges (pia and arachnoid) and subarachnoid space. The most common primary tumors metastasizing to the leptomeninges are breast and lung carcinomas, melanoma, aggressive non-Hodgkin lymphoma, and acute lymphocytic leukemia.


name: steroid-responsive encephalopathy associated with autoimmune thyroiditis


name: SMG5_HUMAN Nonsense-mediated mRNA decay factor SMG5 (sprot)

description: A nonsense-mediated mRNA decay factor SMG5 that is encoded in the genome of human.


BENZOTHIAZYL DISULFIDE

An organic disulfide resulting from the formal oxidative coupling of the thiol groups of two molecules of 1,3-benzothiazole-2-thiol. It is used as an accelerator in the rubber industry.


name: GPAT1_HUMAN Glycerol-3-phosphate acyltransferase 1, mitochondrial (sprot)

description: A glycerol-3-phosphate acyltransferase 1, mitochondrial that is encoded in the genome of human.


name: MLRV_HUMAN Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (sprot)

description: A myosin regulatory light chain 2, ventricular/cardiac muscle isoform that is encoded in the genome of human.


name: PI51C_HUMAN Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (sprot)

description: A phosphatidylinositol 4-phosphate 5-kinase type-1 gamma that is encoded in the genome of human.


name: PAX5_HUMAN Paired box protein Pax-5 (sprot)

description: A paired box protein PAX-5 that is encoded in the genome of human.


name: PTF1A_HUMAN Pancreas transcription factor 1 subunit alpha (sprot)

description: A pancreas transcription factor 1 subunit alpha that is encoded in the genome of human.


name: CKLF_HUMAN Chemokine-like factor (sprot)

description: A chemokine-like factor that is encoded in the genome of human.


buparlisib

An aminopyridine that is 4-(trifluoromethyl)pyridin-2-amine substituted at position 5 by a 2,6-di(morpholin-4-yl)pyrimidin-4-y group. A selective PI3K inhibitor with anti-tumour properties.


name: LYAG_HUMAN Lysosomal alpha-glucosidase (sprot)

description: A lysosomal alpha-glucosidase that is encoded in the genome of human.


name: RTEL1_HUMAN Regulator of telomere elongation helicase 1 (sprot)

description: A regulator of telomere elongation helicase 1 that is encoded in the genome of human.


EFNA1_HUMAN Ephrin-A1 (sprot)

An ephrin-A1 that is encoded in the genome of human.


aldehydo-D-ribose 5-phosphate

The acyclic form of D-ribose 5-phosphate.


name: UBC12_HUMAN NEDD8-conjugating enzyme Ubc12 (sprot)

description: A NEDD8-conjugating enzyme Ubc12 that is encoded in the genome of human.


name: HIG1A_HUMAN HIG1 domain family member 1A, mitochondrial (sprot)

description: A HIG1 domain family member 1A that is encoded in the genome of human.


name: ADCY1_HUMAN Adenylate cyclase type 1 (sprot)

description: An adenylate cyclase type 1 that is encoded in the genome of human.


name: CN37_HUMAN 2',3'-cyclic-nucleotide 3'-phosphodiesterase (sprot)

description: A 2',3'-cyclic-nucleotide 3'-phosphodiesterase that is encoded in the genome of human.


name: TYRP1_HUMAN 5,6-dihydroxyindole-2-carboxylic acid oxidase (sprot)

description: A 5,6-dihydroxyindole-2-carboxylic acid oxidase that is encoded in the genome of human.


invasive breast carcinoma

description: A carcinoma that infiltrates the breast parenchyma. The vast majority are adenocarcinomas arising from the terminal ductal lobular unit (TDLU). Often, the invasive adenocarcinoma co-exists with ductal or lobular carcinoma in situ. It is the most common carcinoma affecting women.


Diamond-Blackfan anemia

description: A congenital aregenerative and often macrocytic anemia with erythroblastopenia.


name: HAT1_HUMAN Histone acetyltransferase type B catalytic subunit (sprot)

description: A histone acetyltransferase type B catalytic subunit that is encoded in the genome of human.


phosphatidylcholine (14:0/22:6)

A phosphatidylcholine 36:6 in which the fatty acyl groups at positions 1 and 2 are specified as C14:0 and C22:6 respectively.


name: ATAT_HUMAN Alpha-tubulin N-acetyltransferase 1 (sprot)

description: An alpha-tubulin N-acetyltransferase 1 that is encoded in the genome of human.


name: FERM1_HUMAN Fermitin family homolog 1 (sprot)

description: A fermitin family homolog 1 that is encoded in the genome of human.


name: TRPV2_HUMAN Transient receptor potential cation channel subfamily V member 2 (sprot)

description: A transient receptor potential cation channel TRPV2 that is encoded in the genome of human.


name: SIK1_HUMAN Serine/threonine-protein kinase SIK1 (sprot)

description: A serine/threonine-protein kinase SIK1 that is encoded in the genome of human.


VTNC_HUMAN Vitronectin (sprot)

A vitronectin that is encoded in the genome of human.


gastrointestinal hamartoma

description: A non-neoplastic, hamartomatous polyp that arises from the stomach, small intestine, and large intestine. This group includes the juvenile polyps and Peutz-Jeghers polyps.


name: nasopharyngeal type undifferentiated carcinoma

description: A nonkeratinizing carcinoma which occurs predominantly in the nasopharynx but also in the tonsils and rarely in other anatomic sites. It is characterized by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, syncytial growth pattern, and a lymphoplasmacytic infiltrate.


REL1_HUMAN Prorelaxin H1 (sprot)

A prorelaxin H1 that is encoded in the genome of human.


SDC3_HUMAN Syndecan-3 (sprot)

A syndecan-3 that is encoded in the genome of human.


SDC1_HUMAN Syndecan-1 (sprot)

A syndecan-1 that is encoded in the genome of human.


DCR1C_HUMAN Protein artemis (sprot)

A protein artemis that is encoded in the genome of human.


name: FCER2_HUMAN Low affinity immunoglobulin epsilon Fc receptor (sprot)

description: A low affinity immunoglobulin epsilon Fc receptor that is encoded in the genome of human.


name: KCNK5_HUMAN Potassium channel subfamily K member 5 (sprot)

description: A potassium channel subfamily K member 5 that is encoded in the genome of human.


name: KCNKG_HUMAN Potassium channel subfamily K member 16 (sprot)

description: A potassium channel subfamily K member 16 that is encoded in the genome of human.


buprenorphine

A morphinane alkaloid that is 7,8-dihydromorphine 6-O-methyl ether in which positions 6 and 14 are joined by a -CH2CH2- bridge, one of the hydrogens of the N-methyl group is substituted by cyclopropyl, and a hydrogen at position 7 is substituted by a 2-hydroxy-3,3-dimethylbutan-2-yl group. It is highly effective for the treatment of opioid use disorder and is also increasingly being used in the treatment of chronic pain.


compartment syndrome

description: Elevated pressure in a confined space enclosed by fascia or eschar, which may lead to vascular compromise and subsequent ischemic injury to the tissue within the space.


telmisartan

A member of the class of  benzimidazoles  used widely in the treatment of hypertension.


TREHALOSE

A trehalose in which both glucose residues have alpha-configuration at the anomeric carbon.


name: VGFR1_HUMAN Vascular endothelial growth factor receptor 1 (sprot)

description: A vascular endothelial growth factor receptor 1 that is encoded in the genome of human.


name: PER1_HUMAN Period circadian protein homolog 1 (sprot)

description: A period circadian protein homolog 1 that is encoded in the genome of human.


chronic rhinosinusitis

description: Chronic form of sinusitis.


name: TNR12_HUMAN Tumor necrosis factor receptor superfamily member 12A (sprot)

description: A tumor necrosis factor receptor superfamily member 12A that is encoded in the genome of human.


name: HLPDA_HUMAN Hypoxia-inducible lipid droplet-associated protein (sprot)

description: A hypoxia-inducible lipid droplet-associated protein that is encoded in the genome of human.


name: TCF21_HUMAN Transcription factor 21 (sprot)

description: A transcription factor 21 that is encoded in the genome of human.


name: ACACA_HUMAN Acetyl-CoA carboxylase 1 (sprot)

description: An acetyl-CoA carboxylase 1 that is encoded in the genome of human.


diacylglycerol (16:0/18:1/0:0)

A 1,2-diglyceride in which the fatty acyl groups at positions 1 and 2 are specified as C16:0 and C20:1 respectively.


name: FHL1_HUMAN Four and a half LIM domains protein 1 (sprot)

description: A four and a half LIM domains protein 1 that is encoded in the genome of human.


name: NRK2_HUMAN Nicotinamide riboside kinase 2 (sprot)

description: A nicotinamide riboside kinase 2 that is encoded in the genome of human.


levetiracetam

A pyrrolidinone and carboxamide that is N-methylpyrrolidin-2-one in which one of the methyl hydrogens is replaced by an aminocarbonyl group, while another is replaced by an ethyl group (the S enantiomer). An anticonvulsant, it is used for the treatment of epilepsy in both human and veterinary medicine.


name: LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (sprot)

description: A leucine-rich repeat serine/threonine-protein kinase 2 that is encoded in the genome of human.


LALBA_HUMAN Alpha-lactalbumin (sprot)

An alpha-lactalbumin that is encoded in the genome of human.


FEN1_HUMAN Flap endonuclease 1 (sprot)

A flap endonuclease 1 that is encoded in the genome of human.


name: TP53B_HUMAN TP53-binding protein 1 (sprot)

description: A TP53-binding protein 1 that is encoded in the genome of human.


name: CRFR1_HUMAN Corticotropin-releasing factor receptor 1 (sprot)

description: A corticotropin-releasing factor receptor 1 that is encoded in the genome of human.


name: EGR2_HUMAN E3 SUMO-protein ligase EGR2 (sprot)

description: An early growth response protein 2 that is encoded in the genome of human.


AMINOPHYLLINE

A mixture comprising of theophylline and ethylenediamine in a 2:1 ratio.


name: STK4_HUMAN Serine/threonine-protein kinase 4 (sprot)

description: A serine/threonine-protein kinase 4 that is encoded in the genome of human.


tilmicosin

A macrolide antibiotic with formula C46H80N2O13. It is used for the treatment of respiratory disease in cattle at high risk of developing bovine respiratory disease associated with Mannheimia haemolytica.


name: TSPO gene translation product isoform PBR-S (human)

description: A translocator protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:B1AH88-1.


name: SC11A_HUMAN Signal peptidase complex catalytic subunit SEC11A (sprot)

description: A signal peptidase complex catalytic subunit SEC11A that is encoded in the genome of human.


name: DNJB6_HUMAN DnaJ homolog subfamily B member 6 (sprot)

description: A DnaJ homolog subfamily B member 6 that is encoded in the genome of human.


GLYOXYLATE

A 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the alpha carbon atom.


name: MAG_HUMAN Myelin-associated glycoprotein (sprot)

description: A myelin-associated glycoprotein that is encoded in the genome of human.


name: frontotemporal dementia with motor neuron disease

description: Frontotemporal dementia with motor neuron disease (FTD-MND) is a type of frontotemporal lobar degeneration characterized by the insidious onset (between the ages of 38-78 years) of dementia-associated psychiatric symptoms (e.g. personality changes, uninhibited behavior, irritability, aggressiveness), memory difficulties, global intellectual impairment, emotional disorders and transcortical motor aphasia that eventually leads to mutism, in addition to the manifestations of motor neuron disease such as neurogenic muscular wasting (similar to what is seen in amyotrophic lateral sclerosis). The disease is progressive, with death occurring 2-5 years after onset.


SEH1_HUMAN Nucleoporin SEH1 (sprot)

A nucleoporin SEH1 that is encoded in the genome of human.


name: LGI1_HUMAN Leucine-rich glioma-inactivated protein 1 (sprot)

description: A leucine-rich glioma-inactivated protein 1 that is encoded in the genome of human.


oxymetazoline

A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion.


LYL1_HUMAN Protein lyl-1 (sprot)

A protein lyl-1 that is encoded in the genome of human.


acoustic neuroma

description: A type of benign brain tumor that begins in the Schwann cells, which produce the myelin that protects the acoustic nerve - the nerve of hearing.


name: TACD2_HUMAN Tumor-associated calcium signal transducer 2 (sprot)

description: A tumor-associated calcium signal transducer 2 that is encoded in the genome of human.


SESN1_HUMAN Sestrin-1 (sprot)

A sestrin-1 that is encoded in the genome of human.


name: ESR2_HUMAN Estrogen receptor beta (sprot)

description: An estrogen receptor beta that is encoded in the genome of human.


oxacillin

A penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6beta.


prostate carcinoma

description: A carcinoma that arises from epithelial cells of the prostate gland.


name: NAR1_HUMAN GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (sprot)

description: A GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 that is encoded in the genome of human.


oral cavity cancer

description: A primary or metastatic malignant neoplasm involving the oral cavity. The majority are squamous cell carcinomas.


5-aminolevulinic acid

The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.


A phenylenediamine in which the amino functions are at positions 1 and 4 of the benzene nucleus.


OSTHENOL

A hydroxycoumarin that is umbelliferone in which the hydrogen at position 8 has been replaced by a prenyl group.


name: GCSP_HUMAN Glycine dehydrogenase (decarboxylating), mitochondrial (sprot)

description: A glycine dehydrogenase (decarboxylating), mitochondrial that is encoded in the genome of human.


name: PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A (sprot)

description: A peptidyl-prolyl cis-trans isomerase A that is encoded in the genome of human.


PGS2_HUMAN Decorin (sprot)

A decorin that is encoded in the genome of human.


erythema multiforme

description: Erythema multiforme (EM) refers to a group ofhypersensitivity disorders characterized by symmetric red, patchy lesions, primarily on the arms and legs. The cause is unknown, but EM frequently occurs in association with herpes simplex virus, suggesting an immunologic process initiated by the virus. In half of the cases, the triggering agents appear to be medications, including anticonvulsants, sulfonamides, nonsteroidal anti-inflammatory drugs, and other antibiotics. In addition, some cases appear to be associated with infectious organisms such as Mycoplasma pneumoniae and many viral agents. Erythema multiforme is the mildest of three skin disorders that are often discussed in relation to each other. It is generally the mildest of the three. More severe is Stevens-Johnson syndrome. The most severe of the three is toxic epidermal necrolysis (TEN).


fibrous dysplasia

description: A genetic, non-inheritable disorder caused by osteoblastic differentiation defects that result in the replacement of bone marrow and trabecular bone by fibrous stroma and immature bone. It usually affects a single bone and less frequently multiple bones. Skull, femur, tibia, and humerus are the most frequently affected bones. It manifests with pain, deformities, and fractures.


2,3-DIHYDROXYBENZOIC ACID

A dihydroxybenzoic acid that is  benzoic acid substituted by hydroxy groups at positions 2 and 3. It occurs naturally in Phyllanthus acidus and in the aquatic fern Salvinia molesta.


name: PATZ1_HUMAN POZ-, AT hook-, and zinc finger-containing protein 1 (sprot)

description: A POZ-, AT hook-, and zinc finger-containing protein 1 that is encoded in the genome of human.


name: KDM5C_HUMAN Lysine-specific demethylase 5C (sprot)

description: A lysine-specific demethylase 5C that is encoded in the genome of human.


osmotic diarrheal disease

description: A diarrhea that results from the presence of osmotically active, poorly absorbed solutes in the bowel lumen that inhibit normal water and electrolyte absorption.


name: RHOB_HUMAN Rho-related GTP-binding protein RhoB (sprot)

description: A Rho-related GTP-binding protein RhoB that is encoded in the genome of human.


name: RB11A_HUMAN Ras-related protein Rab-11A (sprot)

description: A Ras-related protein Rab-11A that is encoded in the genome of human.


methacholine

A quaternary ammonium ion in which the nitrogen is substituted with three methyl groups and a 2-acetoxypropyl group. Parasympathomimetic bronchoconstrictor drug used in clinical diagnosis.


methicillin

A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.


name: CEBPG_HUMAN CCAAT/enhancer-binding protein gamma (sprot)

description: A CCAAT/enhancer-binding protein gamma that is encoded in the genome of human.


focal epithelial hyperplasia

description: Hyperplasia characterized by the presence of a focal proliferation of epithelial cells.


name: RL3_HUMAN Large ribosomal subunit protein uL3 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL3 that is encoded in the genome of human.


name: TRIP4_HUMAN Activating signal cointegrator 1 (sprot)

description: An activating signal cointegrator 1 that is encoded in the genome of human.


THIOCYANATE SODIUM

An organic sodium salt which is the monosodium salt of thiocyanic acid.


name: GRB14_HUMAN Growth factor receptor-bound protein 14 (sprot)

description: A growth factor receptor-bound protein 14 that is encoded in the genome of human.


GSDMD_HUMAN Gasdermin-D (sprot)

A gasdermin-D that is encoded in the genome of human.


name: ACTT1_HUMAN Actin-related protein T1 (sprot)

description: An actin-related protein T1 that is encoded in the genome of human.


AGATHISFLAVONE

A biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-6 and C-8 of the two chromene rings.


name: MP2K5_HUMAN Dual specificity mitogen-activated protein kinase kinase 5 (sprot)

description: A dual specificity mitogen-activated protein kinase kinase 5 that is encoded in the genome of human.


name: OAZ1_HUMAN Ornithine decarboxylase antizyme 1 (sprot)

description: An ornithine decarboxylase antizyme that is encoded in the genome of human.


scleritis

description: Inflammation of the sclera.


ebselen

A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.


STALP_HUMAN AMSH-like protease (sprot)

An AMSH-like protease that is encoded in the genome of human.


name: RFX1_HUMAN MHC class II regulatory factor RFX1 (sprot)

description: An MHC class II regulatory factor RFX1 that is encoded in the genome of human.


name: S14L2_HUMAN SEC14-like protein 2 (sprot)

description: A SEC14-like protein 2 that is encoded in the genome of human.


name: REC8_HUMAN Meiotic recombination protein REC8 homolog (sprot)

description: A meiotic recombination protein REC8 that is encoded in the genome of human.


name: SOLH2_HUMAN Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 (sprot)

description: A spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 that is encoded in the genome of human.


chlorzoxazone

A member of the class of  1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.


hypopituitarism

description: A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.


L-alanine

The L-enantiomer of alanine.


NOX5_HUMAN NADPH oxidase 5 (sprot)

An NADPH oxidase 5 that is encoded in the genome of human.


name: NTRK3_HUMAN NT-3 growth factor receptor (sprot)

description: An NT-3 growth factor receptor that is encoded in the genome of human.


L-fucose

Any deoxygalactose that is deoxygenated at the 6-position.


name: SC5A3_HUMAN Sodium/myo-inositol cotransporter (sprot)

description: A sodium/myo-inositol cotransporter that is encoded in the genome of human.


systemic mycosis

description: A mycosis that involves the lungs, abdominal viscera, bones and or central nervous system.


name: EPS15_HUMAN Epidermal growth factor receptor substrate 15 (sprot)

description: An epidermal growth factor receptor substrate 15 that is encoded in the genome of human.


name: NCOA4_HUMAN Nuclear receptor coactivator 4 (sprot)

description: A nuclear receptor coactivator 4 that is encoded in the genome of human.


name: 4F2_HUMAN Amino acid transporter heavy chain SLC3A2 (sprot)

description: An amino acid transporter heavy chain SLC3A2 that is encoded in the genome of human.


name: CRIP2_HUMAN Cysteine-rich protein 2 (sprot)

description: A cysteine-rich protein 2 that is encoded in the genome of human.


name: liver and intrahepatic bile duct neoplasm

description: A benign or malignant neoplasm that affects the liver parenchyma or intrahepatic bile ducts. Representative examples of benign neoplasms include hepatocellular adenoma, and bile duct adenoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and lymphoma.


ENPL_HUMAN Endoplasmin (sprot)

An endoplasmin that is encoded in the genome of human.


name: EPHB1_HUMAN Ephrin type-B receptor 1 (sprot)

description: An ephrin type-B receptor 1 that is encoded in the genome of human.


A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.


hypogonadotropic hypogonadism

description: Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.


name: YAF2_HUMAN YY1-associated factor 2 (sprot)

description: A YY1-associated factor 2 that is encoded in the genome of human.


PML_HUMAN Protein PML (sprot)

A transcription factor PML that is encoded in the genome of human.


dienogest

A steroid hormone that is 17beta-hydroxy-3-oxoestra-4,9-diene substituted at position 17 by a cyanomethyl group. Used as an oral contraceptive.


lymphopenia

description: Reduction in the number of lymphocytes.


chronic liver failure

description: Liver failure that develops slowly and gradually for some time, possibly for years, often as the result of cirrhosis, or malnutrition.


dofetilide

A tertiary amino compound that is N-ethyl-N-methylethanamine substituted by a 4-[(methylsulfonyl)amino]phenoxy and a 4-[(methylsulfonyl)amino]phenyl group at the terminal carbon atoms respectively. It is used as an  anti-arrhythmia drug.


Thromboembolism

description: The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site.


undifferentiated carcinoma

description: A usually aggressive malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular, squamous, or transitional cell differentiation.


cinnamic acid

A monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. It is found in Cinnamomum cassia.


IL33_HUMAN Interleukin-33 (sprot)

An interleukin-33 that is encoded in the genome of human.


cor pulmonale

description: Hypertrophy and dilation of the right ventricle of the heart that is caused by pulmonary hypertension. This condition is often associated with pulmonary parenchymal or vascular diseases, such as chronic obstructive pulmonary disease and pulmonary embolism.


Chronic hepatitis

description: Hepatitis that lasts for more than six months.


diabetes insipidus

description: A disorder characterized by excretion of large amounts of urine, accompanied by excessive thirst. Causes include deficiency of antidiuretic hormone or failure of the kidneys to respond to antidiuretic hormone. It may also be drug-related.


Progressive visual loss

description: A reduction of previously attained ability to see.


D-psicose

The D-enantiomer of psicose.


ipriflavone

A member of the class of isoflavones that is isoflavone in which the hydrogen at position 7 is replaced by an isopropoxy group. A synthetic isoflavone, it was formerly used for the treatment of osteoporosis, although a randomised controlled study failed to show any benefit. It is still used to prevent osteoporosis in post-menopausal women.


name: UD110_HUMAN UDP-glucuronosyltransferase 1A10 (sprot)

description: A UDP-glucuronosyltransferase 1A10 that is encoded in the genome of human.


name: IC1_HUMAN Plasma protease C1 inhibitor (sprot)

description: A plasma protease C1 inhibitor that is encoded in the genome of human.


name: WIF1_HUMAN Wnt inhibitory factor 1 (sprot)

description: A Wnt inhibitory factor 1 that is encoded in the genome of human.


name: PINX1_HUMAN PIN2/TERF1-interacting telomerase inhibitor 1 (sprot)

description: A pin2-interacting protein X1 that is encoded in the genome of human.


glycolic acid

A 2-hydroxy monocarboxylic acid that is acetic acid where the methyl group has been hydroxylated.


triacetin

A triglyceride obtained by acetylation of the three hydroxy groups of glycerol. It has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections.


ACLY_HUMAN ATP-citrate synthase (sprot)

An ATP-citrate synthase that is encoded in the genome of human.


name: PARP3_HUMAN Protein mono-ADP-ribosyltransferase PARP3 (sprot)

description: A protein mono-ADP-ribosyltransferase PARP3 that is encoded in the genome of human.


name: RPP29_HUMAN Ribonuclease P protein subunit p29 (sprot)

description: A ribonuclease P protein subunit p29 that is encoded in the genome of human.


name: GPR78_HUMAN G-protein coupled receptor 78 (sprot)

description: A G-protein coupled receptor 78 that is encoded in the genome of human.


name: SKP2_HUMAN S-phase kinase-associated protein 2 (sprot)

description: An S-phase kinase-associated protein 2 that is encoded in the genome of human.


exfoliation syndrome

description: An autosomal dominant disorder caused by mutations in the LOXL1 gene, encoding lysyl oxidase homolog 1. The condition is characterized by abnormal fibrillar extracellular material in anterior segment tissues, and may lead to glaucoma.


O-XYLENE

A xylene substituted by methyl groups at positions 1 and 2.


name: TP8L2_HUMAN Tumor necrosis factor alpha-induced protein 8-like protein 2 (sprot)

description: A tumor necrosis factor alpha-induced protein 8-like protein 2 that is encoded in the genome of human.


Gliosis

description: Gliosis is the focal proliferation of glial cells in the central nervous system.


blackwater fever

description: A complication of malaria resulting from hemolysis.


name: VPS4B_HUMAN Vacuolar protein sorting-associated protein 4B (sprot)

description: A vacuolar protein sorting-associated protein 4B that is encoded in the genome of human.


HIS3_HUMAN Histatin-3 (sprot)

A histatin-3 that is encoded in the genome of human.


KTN1_HUMAN Kinectin (sprot)

A kinectin that is encoded in the genome of human.


Right atrial thrombus

description: A thrombus (i.e., a blood clot formed in situ within the vascular system) located in the right atrium of the heart.


phenacetin

A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group.


GSX1_HUMAN GS homeobox 1 (sprot)

A GS homeobox 1 that is encoded in the genome of human.


name: KI21A_HUMAN Kinesin-like protein KIF21A (sprot)

description: A kinesin-like protein KIF21A that is encoded in the genome of human.


name: KIF3A_HUMAN Kinesin-like protein KIF3A (sprot)

description: A kinesin-like protein KIF3A that is encoded in the genome of human.


name: ACHA9_HUMAN Neuronal acetylcholine receptor subunit alpha-9 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-9 that is encoded in the genome of human.


verbascoside

A glycoside that is the alpha-L-rhamnosyl-(1->3)-beta-D-glucoside of hydroxytyrosol in which the hydroxy group at position 4 of the glucopyranosyl moiety has undergone esterification by formal condensation with trans-caffeic acid.


Hyperammonemia

description: An increased concentration of ammonia in the blood.


name: MEIS1_HUMAN Homeobox protein Meis1 (sprot)

description: A homeobox protein Meis1 that is encoded in the genome of human.


name: SO1A2_HUMAN Solute carrier organic anion transporter family member 1A2 (sprot)

description: A solute carrier organic anion transporter family member 1A2 that is encoded in the genome of human.


name: HMGB4_HUMAN High mobility group protein B4 (sprot)

description: A high mobility group protein B4 that is encoded in the genome of human.


acute interstitial pneumonia

description: Acute interstitial pneumonia (AIP), also referred to as Hamman-Rich syndrome, is a rapidly progressive and histologically distinct form of idiopathic interstitial pneumonia.


tirzepatide

A 39-amino acid linear polypeptide which is conjugated to a C20 fatty diacid moiety via a linker connected to lysine-20. It is a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 agonist used for the management of type 2 diabetes mellitus.


name: PLB1_HUMAN Phospholipase B1, membrane-associated (sprot)

description: A phospholipase B1, membrane-associated that is encoded in the genome of human.


methylthioninium chloride

An organic cation that is phenothiazin-5-ium substituted by dimethylamino groups at positions 3 and 7. The chloride salt is the histological dye 'methylene blue'.


name: HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthase, cytoplasmic (sprot)

description: A hydroxymethylglutaryl-CoA synthase, cytoplasmic that is encoded in the genome of human.


name: ABC3C_HUMAN DNA dC->dU-editing enzyme APOBEC-3C (sprot)

description: A DNA dC->dU-editing enzyme APOBEC-3C that is encoded in the genome of human.


primary peritoneal carcinoma

description: A rare carcinoma that arises from the peritoneum and resembles the malignant surface epithelial-stromal tumors that arise from the ovary. Serous adenocarcinoma is the most common histologic variant. It affects women almost exclusively. The diagnosis of primary peritoneal carcinoma can be made only if both ovaries are not involved by tumor, or, if the ovaries are involved, the tumor is confined to the ovarian surface without invasion of the ovarian stroma and the peritoneal involvement is greater than the ovarian surface involvement.


name: TNFL4_HUMAN Tumor necrosis factor ligand superfamily member 4 (sprot)

description: A tumor necrosis factor ligand superfamily member 4 that is encoded in the genome of human.


name: RPA1_HUMAN DNA-directed RNA polymerase I subunit RPA1 (sprot)

description: A DNA-directed RNA polymerase I subunit RPA1 that is encoded in the genome of human.


vericiguat

A pyrazolopyridine that is 5-fluoro-1H-pyrazolo[3,4-b]pyridine in which the amino hydrogen at position 1 has been substituted by a 2-fluorobenzyl group and the hydrogen at position 3 has been substituted by a 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl group. It is a soluble guanylate cyclase stimulator which is used for treatment of chronic heart failure.


name: S22A2_HUMAN Solute carrier family 22 member 2 (sprot)

description: A solute carrier family 22 member 2 that is encoded in the genome of human.


name: CDN2B_HUMAN Cyclin-dependent kinase 4 inhibitor B (sprot)

description: A cyclin-dependent kinase 4 inhibitor B that is encoded in the genome of human.


name: CDN1C_HUMAN Cyclin-dependent kinase inhibitor 1C (sprot)

description: A cyclin-dependent kinase inhibitor 1C that is encoded in the genome of human.


basal-like breast carcinoma

description: A biologic subset of breast carcinoma defined by high expression of genes characteristic of basal epithelial cells, including KRT5 and KRT17, annexin 8, CX3CL1, and TRIM29, and usually by lack of expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). It is the most common subtype of breast cancer associated with BRCA1 mutations, and is associated with a poor prognosis.


teniposide

A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding.


name: NEIL2_HUMAN Endonuclease 8-like 2 (sprot)

description: An endonuclease 8-like 2 that is encoded in the genome of human.


name: LSR_HUMAN Lipolysis-stimulated lipoprotein receptor (sprot)

description: A lipolysis-stimulated lipoprotein receptor that is encoded in the genome of human.


name: UCHL5_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L5 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase isozyme L5 that is encoded in the genome of human.


name: PBX1_HUMAN Pre-B-cell leukemia transcription factor 1 (sprot)

description: A pre-B-cell leukemia transcription factor 1 that is encoded in the genome of human.


name: IMPA1_HUMAN Inositol monophosphatase 1 (sprot)

description: An inositol monophosphatase 1 that is encoded in the genome of human.


name: ADA2_HUMAN Adenosine deaminase 2 (sprot)

description: An adenosine deaminase 2 that is encoded in the genome of human.


name: TPC1_HUMAN Two pore channel protein 1 (sprot)

description: A two pore channel protein 1 that is encoded in the genome of human.


PRDX4_HUMAN Peroxiredoxin-4 (sprot)

A peroxiredoxin-4 that is encoded in the genome of human.


spina bifida

description: A congenital neural tube defect in which vertebrae are not fully formed. It results in the protrusion of the spinal cord through the opening of the vertebrae.


TETRAC

A monocarboxylic acid that is thyroacetic acid carrying four iodo substituents at positions 3, 3', 5 and 5'.


name: CHM2B_HUMAN Charged multivesicular body protein 2b (sprot)

description: A charged multivesicular body protein 2b that is encoded in the genome of human.


Reduced impulse control

description: Reduced ability to control, or a failure to resist a temptation, urge, or impulse.


name: TRI18_HUMAN E3 ubiquitin-protein ligase Midline-1 (sprot)

description: An E3 ubiquitin-protein ligase Midline-1 that is encoded in the genome of human.


name: TMLH_HUMAN Trimethyllysine dioxygenase, mitochondrial (sprot)

description: A trimethyllysine dioxygenase, mitochondrial that is encoded in the genome of human.


trinitrophenol

A C-nitro compound comprising phenol having three nitro substtituents at the 2-, 4- and 6-positions.


An alpha-2-macroglobulin that is encoded in the genome of human.


name: ZEP2_HUMAN Transcription factor HIVEP2 (sprot)

description: A transcription factor HIVEP2 that is encoded in the genome of human.


name: BMP10_HUMAN Bone morphogenetic protein 10 (sprot)

description: A bone morphogenetic protein 10 that is encoded in the genome of human.


name: HPGDS_HUMAN Hematopoietic prostaglandin D synthase (sprot)

description: A glutathione-requiring prostaglandin D synthase that is encoded in the genome of human.


N-FERULOYL SEROTONIN

A member of the class of hydroxyindoles that is the N-feruloyl derivative of serotonin.


name: RL23_HUMAN Large ribosomal subunit protein uL14 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL14 that is encoded in the genome of human.


cisapride

The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.


Nausea

description: A sensation of unease in the stomach together with an urge to vomit.


chronic childhood arthritis

description: An older, deprecated term that encompassed three major types of autoimmune or autoinflammatory arthritis in children: systemic-onset, pauciarticular, or polyarticular arthritis. The juvenile rheumatoid arthritis classification system has been replaced by the International League of Associations for Rheumatology (ILAR) juvenile idiopathic arthritis classification system.


name: UGPA_HUMAN UTP--glucose-1-phosphate uridylyltransferase (sprot)

description: A UTP--glucose-1-phosphate uridylyltransferase that is encoded in the genome of human.


N-acetylserotonin

An N-acylserotonin resulting from the formal condensation of the primary amino group of serotonin with the carboxy group of acetic acid.


CAN10_HUMAN Calpain-10 (sprot)

A calpain-10 that is encoded in the genome of human.


name: GNAT1_HUMAN Guanine nucleotide-binding protein G(t) subunit alpha-1 (sprot)

description: A guanine nucleotide-binding protein G(t) subunit alpha-1 that is encoded in the genome of human.


name: NCOR1_HUMAN Nuclear receptor corepressor 1 (sprot)

description: A nuclear receptor corepressor 1 that is encoded in the genome of human.


STC1_HUMAN Stanniocalcin-1 (sprot)

A stanniocalcin-1 that is encoded in the genome of human.


JPH2_HUMAN Junctophilin-2 (sprot)

A junctophilin-2 that is encoded in the genome of human.


name: ZBED1_HUMAN E3 SUMO-protein ligase ZBED1 (sprot)

description: An E3 SUMO-protein ligase ZBED1 that is encoded in the genome of human.


atypical endometrial hyperplasia

description: An endometrial hyperplasia characterized by cytologic and architectural changes which may lead to endometrial carcinoma. Despite the atypical features and possible course, there is debate on whether to consider this a neoplasm. The relationship with endometrial intraepithelial neoplasia is also unclear.


name: ACSM3_HUMAN Acyl-coenzyme A synthetase ACSM3, mitochondrial (sprot)

description: An acyl-coenzyme A synthetase ACSM3, mitochondrial that is encoded in the genome of human.


name: ELOV5_HUMAN Very long chain fatty acid elongase 5 (sprot)

description: A very long chain fatty acid elongase 5 that is encoded in the genome of human.


Metrorrhagia

description: Bleeding at irregular intervals.


name: PP1G_HUMAN Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (sprot)

description: A serine/threonine-protein phosphatase PP1-gamma catalytic subunit that is encoded in the genome of human.


name: RAI1_HUMAN Retinoic acid-induced protein 1 (sprot)

description: A retinoic acid-induced protein 1 that is encoded in the genome of human.


name: NOL9_HUMAN Polynucleotide 5'-hydroxyl-kinase NOL9 (sprot)

description: A polynucleotide 5'-hydroxyl-kinase NOL9 that is encoded in the genome of human.


A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP in which the hydrogen at position 2 on the purine fragment is replaced by a 4-chlorophenylthio group.


name: TRIM4_HUMAN E3 ubiquitin-protein ligase TRIM4 (sprot)

description: An E3 ubiquitin-protein ligase TRIM4 that is encoded in the genome of human.


name: IFIT3_HUMAN Interferon-induced protein with tetratricopeptide repeats 3 (sprot)

description: An interferon-induced protein with tetratricopeptide repeats 3 that is encoded in the genome of human.


name: torsin-1A-interacting protein 2 isoform IFRG15 (human)

description: A torsin-1A-interacting protein 2 isoform IFRG15 that is encoded in the genome of human.


name: UBP53_HUMAN Inactive ubiquitin carboxyl-terminal hydrolase 53 (sprot)

description: An inactive ubiquitin carboxyl-terminal hydrolase 53 that is encoded in the genome of human.


arterial occlusion

description: Complete closure of the normally patent lumen of the blood vessels which carry blood away from the heart.


hyperlipoproteinemia

description: An elevated concentration of lipoproteins.


name: AGTR2_HUMAN Type-2 angiotensin II receptor (sprot)

description: An angiotensin II receptor 2 that is encoded in the genome of human.


name: VPS72_HUMAN Vacuolar protein sorting-associated protein 72 homolog (sprot)

description: A vacuolar protein sorting-associated protein 72 that is encoded in the genome of human.


Shwachman-Diamond syndrome

description: Shwachman-Diamond syndrome (SDS) is a rare multisystemic syndrome characterized by chronic and usually mild neutropenia, pancreatic exocrine insufficiency associated with steatorrhea and growth failure, skeletal dysplasia with short stature, and an increased risk of bone marrow aplasia or leukemic transformation.


name: GIT2_HUMAN ARF GTPase-activating protein GIT2 (sprot)

description: An ARF GTPase-activating protein GIT2 that is encoded in the genome of human.


An alpha-1-antichymotrypsin that is encoded in the genome of human.


AURINTRICARBOXYLIC ACID

A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.


naringenin

A trihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 6 and 4'.


isovaleric acidemia

description: Isovaleric acidemia (IVA) is an autosomal recessively inherited organic aciduria characterized by a deficiency in isovaleryl-CoA dehydrogenase, that has wide clinical variability and that can present in infancy with acute manifestations of vomiting, failure to thrive, seizures, lethargy, a characteristic ''sweaty feet'' odor, acute pancreatitis and mild to severe developmental delay or in childhood with metabolic acidosis (brought on by prolonged fasting, an increased intake of protein-rich food or infections) and that can be fatal if not treated immediately. Chronic intermittent presentations and asymptomatic patients have also been reported.


name: TRML2_HUMAN Trem-like transcript 2 protein (sprot)

description: A trem-like transcript 2 protein that is encoded in the genome of human.


name: SKP1_HUMAN S-phase kinase-associated protein 1 (sprot)

description: An S-phase kinase-associated protein 1A that is encoded in the genome of human.


papillary renal cell carcinoma

description: A rare subtype of renal cell carcinoma, arising from the renal tubular epithelium and showing a papillary growth pattern, which typically manifests with hematuria, flank pain, palpable abdominal mass or nonspecific symptoms, such as fatigue, weight loss or fever. Symptoms related to metastatic spread, such as bone pain or persistent cough, are frequently associated since early diagnosis is not common. It is typically multifocal, bilateral, and in most cases sporadic, although different hereditary syndromes, such as Hereditary leiomyoma renal cell carcinoma, Birt-Hogg-DubC) syndrome and Tuberous sclerosis, may predispose to the development of papillary renal cell carcinoma.


name: TIM50_HUMAN Mitochondrial import inner membrane translocase subunit TIM50 (sprot)

description: A mitochondrial import inner membrane translocase subunit TIM50 that is encoded in the genome of human.


gastroesophageal reflux disease

description: A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa.


Recurrent infections

description: Increased susceptibility to infections.


name: SMG1_HUMAN Serine/threonine-protein kinase SMG1 (sprot)

description: A serine/threonine-protein kinase SMG1 that is encoded in the genome of human.


Decreased testicular size

description: Reduced volume of the testicle (the male gonad).


PININ_HUMAN Pinin (sprot)

A pinin that is encoded in the genome of human.


name: BAKOR_HUMAN Beclin 1-associated autophagy-related key regulator (sprot)

description: A beclin 1-associated autophagy-related key regulator that is encoded in the genome of human.


name: RAB2A_HUMAN Ras-related protein Rab-2A (sprot)

description: A Ras-related protein Rab-2A that is encoded in the genome of human.


name: CDK14_HUMAN Cyclin-dependent kinase 14 (sprot)

description: A cyclin-dependent kinase 14 that is encoded in the genome of human.


name: HIPK1_HUMAN Homeodomain-interacting protein kinase 1 (sprot)

description: A homeodomain-interacting protein kinase 1 that is encoded in the genome of human.


phosphatidylcholine (P-38:4)

A 1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine in which the unspecified alk-1-enyl and acyl groups at positions 1 and 2 contain 38 carbon atoms in total with 4 additional double bonds in the acyl moiety.


name: ETFB_HUMAN Electron transfer flavoprotein subunit beta (sprot)

description: An electron transfer flavoprotein subunit beta that is encoded in the genome of human.


tumor lysis syndrome

description: A condition of metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells. Tumor lysis syndrome typically occurs in aggressive, rapidly proliferating lymphoproliferative disorders. Burkitt lymphoma and T cell acute lymphoblastic leukemia are commonly associated with this syndrome. Metabolic abnormalities include hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia and may result in renal failure, multiple organ failure, and death.


Fanconi renotubular syndrome

description: A genetic or acquired disorder characterized by impairment of the function of the proximal tubules of the kidney. It results in decreased reabsorption of electrolytes, glucose, amino acids, and other nutrients.


AGO2_HUMAN Protein argonaute-2 (sprot)

A protein argonaute-2 that is encoded in the genome of human.


lipodystrophy

description: A congenital or acquired disorder characterized by abnormal loss or redistribution of the adipose tissue in the body.


porphyria

description: Porphyria is a group of diseases in which substances called porphyrins build up, negatively affecting the skin or nervous system. Most types are inherited, but porphyria cutanea tarda may also be due to increased iron in the liver, hepatitis C, alcohol, or HIV/AIDS.


Myocardial necrosis

description: Irreversible damage to heart tissue (myocardium) due to lack of oxygen after a heart attack (myocardial infarction).


FZD1_HUMAN Frizzled-1 (sprot)

A frizzled-1 that is encoded in the genome of human.


WNT6_HUMAN Protein Wnt-6 (sprot)

A protein Wnt-6 that is encoded in the genome of human.


name: EDNRB_HUMAN Endothelin receptor type B (sprot)

description: An endothelin receptor type B that is encoded in the genome of human.


name: PIGR_HUMAN Polymeric immunoglobulin receptor (sprot)

description: A polymeric immunoglobulin receptor that is encoded in the genome of human.


bupivacaine

A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.


name: ANFB_HUMAN Natriuretic peptides B (sprot)

description: A natriuretic peptides B that is encoded in the genome of human.


name: EMAL4_HUMAN Echinoderm microtubule-associated protein-like 4 (sprot)

description: An echinoderm microtubule-associated protein-like 4 that is encoded in the genome of human.


name: CXA3_HUMAN Gap junction alpha-3 protein (sprot)

description: A gap junction alpha-3 protein that is encoded in the genome of human.


name: AKAP9_HUMAN A-kinase anchor protein 9 (sprot)

description: An A-kinase anchor protein 9 that is encoded in the genome of human.


name: SELPL_HUMAN P-selectin glycoprotein ligand 1 (sprot)

description: A P-selectin glycoprotein ligand 1 that is encoded in the genome of human.


name: PRP18_HUMAN Pre-mRNA-splicing factor 18 (sprot)

description: A pre-mRNA-splicing factor 18 that is encoded in the genome of human.


name: TM171_HUMAN Transmembrane protein 171 (sprot)

description: A transmembrane protein 171 that is encoded in the genome of human.


spectinomycin

A pyranobenzodioxin and antibiotic that is active against gram-negative bacteria and used (as its dihydrochloride pentahydrate) to treat gonorrhea. It is produced by the bacterium Streptomyces spectabilis.


tectorigenin

A methoxyisoflavone that is  isoflavone substituted by a methoxy group at position 6 and hydroxy groups at positions 5, 7 and 4' respectively.


MALT lymphoma

description: An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes (centrocyte-like cells). The gastrointestinal tract is the most common site of involvement. Other common sites of involvement include lung, head and neck, ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated with the presence of H. pylori infection. (WHO, 2001)


retinal cancer

description: A malignant neoplasm involving the retina.


name: HNF6_HUMAN Hepatocyte nuclear factor 6 (sprot)

description: A hepatocyte nuclear factor 6 that is encoded in the genome of human.


CTNL1_HUMAN Alpha-catulin (sprot)

An alpha-catulin that is encoded in the genome of human.


name: HNRPC_HUMAN Heterogeneous nuclear ribonucleoproteins C1/C2 (sprot)

description: A heterogeneous nuclear ribonucleoproteins C1/C2 that is encoded in the genome of human.


name: PLP2_HUMAN Proteolipid protein 2 (sprot)

description: A proteolipid protein 2 that is encoded in the genome of human.


sulpiride

A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.


CD59_HUMAN CD59 glycoprotein (sprot)

A CD59 glycoprotein that is encoded in the genome of human.


name: SOSB1_HUMAN SOSS complex subunit B1 (sprot)

description: A SOSS complex subunit B1 that is encoded in the genome of human.


digestive system infectious disorder

description: A viral, bacterial, fungal, or parasitic infectious process that affects the digestive system.


name: OVGP1_HUMAN Oviduct-specific glycoprotein (sprot)

description: An oviduct-specific glycoprotein that is encoded in the genome of human.


Bcl-2-like protein 2 isoform 1 (human)

A Bcl-2-like protein 2 isoform 1 that is encoded in the genome of human.


name: ARAP3_HUMAN Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (sprot)

description: An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 that is encoded in the genome of human.


psoriatic arthritis

description: Joint inflammation associated with psoriasis.


name: IER5_HUMAN Immediate early response gene 5 protein (sprot)

description: An immediate early response gene 5 protein that is encoded in the genome of human.


Xerostomia

description: Dryness of the mouth due to salivary gland dysfunction.


name: HXA4_HUMAN Homeobox protein Hox-A4 (sprot)

description: A homeobox protein Hox-A4 that is encoded in the genome of human.


name: NAMPT_HUMAN Nicotinamide phosphoribosyltransferase (sprot)

description: A nicotinamide phosphoribosyltransferase that is encoded in the genome of human.


BROMOPYRUVATE

A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is replaced by bromine. Synthetic brominated derivative and structural analog of pyruvic acid. Highly reactive alkylating agent. Anti-cancer drug


α-ketoisocaproate

A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.


name: NRCAM_HUMAN Neuronal cell adhesion molecule (sprot)

description: A neuronal cell adhesion molecule that is encoded in the genome of human.


SEM3F_HUMAN Semaphorin-3F (sprot)

A semaphorin-3F that is encoded in the genome of human.


phosphatidylserine (18:0/20:4)

A phosphatidyl-L-serine in which one acyl group has 18 carbons and is fully saturated while the other has 20 carbons and 4 double bonds.


name: ECM2_HUMAN Extracellular matrix protein 2 (sprot)

description: An extracellular matrix protein 2 that is encoded in the genome of human.


name: IL7RA_HUMAN Interleukin-7 receptor subunit alpha (sprot)

description: An interleukin-7 receptor subunit alpha that is encoded in the genome of human.


GEMI_HUMAN Geminin (sprot)

A geminin that is encoded in the genome of human.


ERGOSTEROL PEROXIDE

An ergostanoid that is ergosta-6,22-dien-3-ol with a peroxy group between positions 5 and 8 (the 3beta,5alpha,8alpha,22E stereoisomer). Isolated from Ganoderma lucidum and Cordyceps sinensis, it exhibits antimycobacterial, trypanocidal and antineoplastic activities.


TUFT1_HUMAN Tuftelin (sprot)

A tuftelin that is encoded in the genome of human.


name: FFAR3_HUMAN Free fatty acid receptor 3 (sprot)

description: A free fatty acid receptor 3 that is encoded in the genome of human.


DIPHENYLETHER

An aromatic ether in which the oxygen is attached to two phenyl substituents. It has been found in muscat grapes and vanilla.


A carboxamidinium ion obtained by protonation of  the amidino group of benzamidine. Major species at pH 7.3.


name: ICAM2_HUMAN Intercellular adhesion molecule 2 (sprot)

description: An intercellular adhesion molecule 2 that is encoded in the genome of human.


name: FBXL2_HUMAN F-box/LRR-repeat protein 2 (sprot)

description: An F-box/LRR-repeat protein 2 that is encoded in the genome of human.


name: P85B_HUMAN Phosphatidylinositol 3-kinase regulatory subunit beta (sprot)

description: A phosphatidylinositol 3-kinase regulatory subunit beta that is encoded in the genome of human.


IPO9_HUMAN Importin-9 (sprot)

An importin-9 that is encoded in the genome of human.


T-cell acute lymphoblastic leukemia

description: Acute lymphoblastic leukemia of T-cell origin. It comprises about 15% of childhood cases and 25% of adult cases. It is more common in males than females. (WHO, 2001)


D-ALLOSE

The D-enantiomer of allopyranose.


name: AKTS1_HUMAN Proline-rich AKT1 substrate 1 (sprot)

description: A proline-rich AKT1 substrate 1 that is encoded in the genome of human.


name: ALX1_HUMAN ALX homeobox protein 1 (sprot)

description: An ALX homeobox protein 1 that is encoded in the genome of human.


name: PTN21_HUMAN Tyrosine-protein phosphatase non-receptor type 21 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 21 that is encoded in the genome of human.


name: TGFA_HUMAN Protransforming growth factor alpha (sprot)

description: A protransforming growth factor alpha that is encoded in the genome of human.


name: CLC6A_HUMAN C-type lectin domain family 6 member A (sprot)

description: A C-type lectin domain family 6 member A that is encoded in the genome of human.


name: LASP1_HUMAN LIM and SH3 domain protein 1 (sprot)

description: A LIM and SH3 domain protein 1 that is encoded in the genome of human.


PHF6_HUMAN PHD finger protein 6 (sprot)

A PHD finger protein 6 that is encoded in the genome of human.


L-phenylalanine

The L-enantiomer of phenylalanine.


name: MGRN1_HUMAN E3 ubiquitin-protein ligase MGRN1 (sprot)

description: An E3 ubiquitin-protein ligase MGRN1 that is encoded in the genome of human.


name: PDCD6_HUMAN Programmed cell death protein 6 (sprot)

description: A programmed cell death protein 6 that is encoded in the genome of human.


name: BACD1_HUMAN BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (sprot)

description: A BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 that is encoded in the genome of human.


name: SATB2_HUMAN DNA-binding protein SATB2 (sprot)

description: A DNA-binding protein SATB2 that is encoded in the genome of human.


eltrombopag

A hydrazine in which each nitrogen atom is substituted, one by a 3'-carboxy-2-hydroxy[1,1'-biphenyl]-3-yl group and the other by a 1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene group.  A small molecule agonist of the c-mpl (TpoR) receptor (the physiological target of the hormone thrombopoietin), it has been developed as a medication for conditions that lead to thrombocytopenia (abnormally low platelet counts).


thrombotic thrombocytopenic purpura

description: Thrombotic thrombocytopenic purpura (TTP) is an aggressive and life-threatening form of thrombotic microangiopathy (TMA) characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and organ failure of variable severity and is comprised of congenital TTP and acquired TTP.


name: DNM3L_HUMAN DNA (cytosine-5)-methyltransferase 3-like (sprot)

description: A DNA (cytosine-5)-methyltransferase 3-like that is encoded in the genome of human.


name: PLPR2_HUMAN Phospholipid phosphatase-related protein type 2 (sprot)

description: A phospholipid phosphatase-related protein type 2 that is encoded in the genome of human.


name: PLPR3_HUMAN Phospholipid phosphatase-related protein type 3 (sprot)

description: A phospholipid phosphatase-related protein type 3 that is encoded in the genome of human.


CAH3_HUMAN Carbonic anhydrase 3 (sprot)

A carbonic anhydrase 3 that is encoded in the genome of human.


contact dermatitis

description: An inflammatory skin condition caused by direct contact between the skin and either an irritating substance or an allergen.


name: GBP5_HUMAN Guanylate-binding protein 5 (sprot)

description: A guanylate-binding protein 5 that is encoded in the genome of human.


name: IRF8_HUMAN Interferon regulatory factor 8 (sprot)

description: An interferon regulatory factor 8 that is encoded in the genome of human.


Respiratory distress

description: Respiratory distress is objectively observable as the physical or emotional consequences from the experience of dyspnea. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea.


KLK7_HUMAN Kallikrein-7 (sprot)

A kallikrein-7 that is encoded in the genome of human.


O-propanoyl-L-carnitine

An optically active O-acylcarnitine compound having propanoyl as the acyl substituent and (R)-configuration at the 3-position.


name: systemic primary carnitine deficiency disease

description: Systemic primary carnitine deficiency (SPCD) is a potentially lethal disorder of fatty acid oxidation characterized classically by early childhood onset cardiomyopathy often with weakness and hypotonia, failure to thrive and recurrent hypoglycemic hypoketotic seizures and/or coma.


xanthine

An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.


name: RHG31_HUMAN Rho GTPase-activating protein 31 (sprot)

description: A Rho GTPase-activating protein 31 that is encoded in the genome of human.


phosphatidylethanolamine (16:0/20:5)

1,2-diacyl-sn-glycero-3-phosphoethanolamine in which the acyl group at C-1 contains 16 carbons and no double bonds while that at C-2 contains 20 carbons and 5 double bonds.


name: CSRP3_HUMAN Cysteine and glycine-rich protein 3 (sprot)

description: A cysteine and glycine-rich protein 3 that is encoded in the genome of human.


irritant dermatitis

description: An inflammatory skin condition caused by direct contact between the skin and an irritating substance. It is typically manifested by erythema, mild edema, and scaling at the affected site.


name: SYCE3_HUMAN Synaptonemal complex central element protein 3 (sprot)

description: A synaptonemal complex central element protein 3 that is encoded in the genome of human.


name: ROA3_HUMAN Heterogeneous nuclear ribonucleoprotein A3 (sprot)

description: A heterogeneous nuclear ribonucleoprotein A3 that is encoded in the genome of human.


name: TBC3F_HUMAN TBC1 domain family member 3F (sprot)

description: A TBC1 domain family member 3F that is encoded in the genome of human.


name: TBC3A_HUMAN TBC1 domain family member 3 (sprot)

description: A TBC1 domain family member 3 that is encoded in the genome of human.


tafluprost

A prostaglandin Falpha that is prostaglandin F2alpha in which the carboxylic acid function has been converted to the corresponding isopropyl ester and the 3-hydroxy-1-octenyl side-chain is substituted by 3,3-difluoro-4-phenoxybut-1-enyl. Used for treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.


name: ELMO1_HUMAN Engulfment and cell motility protein 1 (sprot)

description: An engulfment and cell motility protein 1 that is encoded in the genome of human.


name: DRD5_HUMAN D(1B) dopamine receptor (sprot)

description: A D(1B) dopamine receptor that is encoded in the genome of human.


name: AGRP_HUMAN Agouti-related protein (sprot)

description: An agouti-related protein that is encoded in the genome of human.


theophylline

A dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea.


glyceraldehyde 3-phosphate

An aldotriose phosphate that is the 3-phospho derivative of glyceraldehyde. It is an important metabolic intermediate in several central metabolic pathways in all organisms.


Severe hearing impairment

description: A severe form of hearing impairment.


name: HCN3_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (sprot)

description: A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is encoded in the genome of human.


phosphatidylcholine (15:1/18:2)

A phosphatidylcholine 33:3 in which the fatty acyl groups at positions 1 and 2 are specified as C15:1 and C18:2 respectively.


name: HEBP2_HUMAN Heme-binding protein 2 (sprot)

description: A heme-binding protein 2 that is encoded in the genome of human.


name: DVLP1_HUMAN Putative segment polarity protein dishevelled homolog DVL1P1 (sprot)

description: A segment polarity protein dishevelled DVL-1-like that is encoded in the genome of human.


boceprevir

A synthetic tripeptide consisting of N-(tert-butylcarbamoyl)-3-methyl-L-valyl, a cyclopropyl-fused prolyl and 3-amino-4-cyclobutyl-2-oxobutanamide residues joined in sequence. Used for treatment of chronic hepatitis C virus genotype 1 infection.


celiac disease

description: An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.


name: BHA15_HUMAN Class A basic helix-loop-helix protein 15 (sprot)

description: A class A basic helix-loop-helix protein 15 that is encoded in the genome of human.


DIBROMOACETIC ACID

A monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are replaced by bromo groups.


sodium stibogluconate

A D-gluconate adduct of indefinite composition containing between 30 and 34% of antimony(V), calculated with reference to dried and methanol-free substance. It is used as a treatment for leishmaniasis.


long QT syndrome 15

description: Any long QT syndrome in which the cause of the disease is a mutation in the CALM2 gene.


name: UD14_HUMAN UDP-glucuronosyltransferase 1A4 (sprot)

description: A UDP-glucuronosyltransferase 1A4 that is encoded in the genome of human.


Permanent atrial fibrillation

description: Atrial fibrillation (AF) that cannot be successfully terminated by cardioversion, and longstanding (more than 1 year) AF, where cardioversion is not indicated or has not been attempted, is termed permanent.


anterior ischemic optic neuropathy

description: Anterior ischemic optic neuropathy (AION) is an eye disease characterized by infarction of the optic disk leading to vision loss. It can be nonarteritic (nonarteritic anterior ischemic optic neuropathy or NAION) or arteritic, the latter being associated with giant cell arteritis (GCA; often termed temporal arteritis). Vision loss with both varieties is typically rapid (over minutes, hours, or days) and painless. Symptoms such as a general feeling of being unwell (malaise), muscle aches and pains, headaches over the temple, pain when combing hair, pain in the jaw after chewing, and tenderness over the temporal artery (one of the major arteries of the head) may be present with giant cell arteritis. At exam, visual acuity is reduced and the optic disk is swollen. In both subtypes, visual field examination is often reduced in the inferior and central visual fields. The visual loss is usually permanent, with some recovery possibly occurring within the first weeks or months. The arteritic variety is treated with corticosteroids. Treatment of the nonarteritic variety withaspirinor corticosteroids has not been helpful.


sleep disorder

description: A change from the patient's baseline sleeping pattern, in the hours slept and/or an alteration/dysfunction in the stages of sleep.


salicylamide

The simplest member of the class of salicylamides derived from salicylic acid.


BENAZEPRIL HYDROCHLORIDE

A hydrochloride salt resulting from the reaction of benazepril with 1 mol eq. of hydrogen chloride. It is used as a prodrug for angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.


name: TREM2_HUMAN Triggering receptor expressed on myeloid cells 2 (sprot)

description: A triggering receptor expressed on myeloid cells 2 that is encoded in the genome of human.


phosphatidylserine (17:1/18:1)

A phosphatidylserine 35:2 in which the acyl group at C-1 contains 17 carbons and 1 double bind while that at C-2 contains 18 carbons and 1 double bonds.


GLR_HUMAN Glucagon receptor (sprot)

A glucagon receptor that is encoded in the genome of human.


pulmonary venoocclusive disease

description: A disorder characterized by pulmonary venous constriction or occlusion, resulting in pulmonary hypertension.


name: TBX22_HUMAN T-box transcription factor TBX22 (sprot)

description: A T-box transcription factor TBX22 that is encoded in the genome of human.


name: MTNB_HUMAN Methylthioribulose-1-phosphate dehydratase (sprot)

description: A methylthioribulose-1-phosphate dehydratase that is encoded in the genome of human.


name: KCNKI_HUMAN Potassium channel subfamily K member 18 (sprot)

description: A potassium channel subfamily K member 18 that is encoded in the genome of human.


name: SFPQ_HUMAN Splicing factor, proline- and glutamine-rich (sprot)

description: A splicing factor, proline- and glutamine-rich that is encoded in the genome of human.


ENOA_HUMAN Alpha-enolase (sprot)

An alpha-enolase that is encoded in the genome of human.


name: H2B1A_HUMAN Histone H2B type 1-A (sprot)

description: A histone H2B type 1-A that is encoded in the genome of human.


etrasimod

An organic heterotricyclic compound that is 1,2,3,4-tetrahydrocyclopenta[b]indole substituted by carboxymethyl and [4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy groups at positions 3R and 7, respectively. It is a potent and functional antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50 = 1.88 nM in CHO cells).


KISSR_HUMAN KiSS-1 receptor (sprot)

A KiSS-1 receptor that is encoded in the genome of human.


name: LYN_HUMAN Tyrosine-protein kinase Lyn (sprot)

description: A tyrosine-protein kinase Lyn that is encoded in the genome of human.