sarcoma

description: A usually aggressive malignant neoplasm of the soft tissue or bone. It arises from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The prognosis depends largely on the degree of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma.


Respiratory insufficiency

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Impairment of gas exchange within the lungs secondary to a disease process, neoplasm, or trauma, possibly resulting in hypoxia, hypercarbia, or both, but not requiring intubation or mechanical ventilation. Patients are normally managed with pharmaceutical therapy, supplemental oxygen, or both.


breast neoplasm

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A benign or malignant neoplasm of the breast parenchyma. It can originate from the ducts, lobules or the breast adipose tissue. Breast neoplasms are much more common in females than males.


MEPHEDRONE

An aromatic ketone that is propiophenone substituted at C-4 and at C-beta with methyl and methylamino groups respectively. It is a synthetic stimulant and entactogen drug of the amphetamine and cathinone classes.


name: DRD1_HUMAN D(1A) dopamine receptor (sprot)

description: A D(1A) dopamine receptor that is encoded in the genome of human.


name: APCL_HUMAN Adenomatous polyposis coli protein 2 (sprot)

description: An adenomatous polyposis coli protein 2 that is encoded in the genome of human.


name: USF1_HUMAN Upstream stimulatory factor 1 (sprot)

description: An upstream stimulatory factor 1 that is encoded in the genome of human.


CRY1_HUMAN Cryptochrome-1 (sprot)

A cryptochrome-1 that is encoded in the genome of human.


INSR_HUMAN Insulin receptor (sprot)

An insulin receptor that is encoded in the genome of human.


name: IRS4_HUMAN Insulin receptor substrate 4 (sprot)

description: An insulin receptor substrate 4 that is encoded in the genome of human.


name: TRAF3_HUMAN TNF receptor-associated factor 3 (sprot)

description: A TNF receptor-associated factor 3 that is encoded in the genome of human.


marimastat

A secondary carboxamide resulting from the foraml condensation of the carboxy group of (2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the alpha-amino group of N,3-dimethyl-L-valinamide.


myopia

description: The condition in which the individual does not see far distances clearly.


carnosine

A dipeptide that is the N-(beta-alanyl) derivative of L-histidine.


name: GSTO1_HUMAN Glutathione S-transferase omega-1 (sprot)

description: A glutathione S-transferase omega-1 that is encoded in the genome of human.


name: PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 1 that is encoded in the genome of human.


classic familial adenomatous polyposis

description: Familial adenomatous polyposis (FAP) is characterized by the development of hundreds to thousands of adenomas in the rectum and colon during the second decade of life.


name: GPIX_HUMAN Platelet glycoprotein IX (sprot)

description: A platelet glycoprotein IX that is encoded in the genome of human.


name: MICA_HUMAN MHC class I polypeptide-related sequence A (sprot)

description: An MHC class I polypeptide-related sequence A that is encoded in the genome of human.


hemolytic anemia

description: Anemia resulting from the premature destruction of the peripheral blood red cells. It may be congenital or it may be caused by infections, medications, or malignancies.


name: CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G (sprot)

description: A voltage-dependent T-type calcium channel subunit alpha-1G that is encoded in the genome of human.


bladder transitional cell carcinoma

description: The most common morphologic subtype of urinary bladder carcinoma (over 90% of cases). It arises from the transitional epithelium. It most often affects males in their sixth and seventh decades of life. Hematuria is the most common symptom at presentation. Pathologic stage is the strongest predictor of survival.


DYN2_HUMAN Dynamin-2 (sprot)

A dynamin-2 that is encoded in the genome of human.


name: GPBAR_HUMAN G-protein coupled bile acid receptor 1 (sprot)

description: A G-protein coupled bile acid receptor 1 that is encoded in the genome of human.


name: TAB2_HUMAN TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (sprot)

description: A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 that is encoded in the genome of human.


imipramine

A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.


cardiac arrest

description: Cessation of breathing and/or cardiac function.


TM1L2_HUMAN TOM1-like protein 2 (sprot)

A TOM1-like protein 2 that is encoded in the genome of human.


fenofibrate

A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.


name: FOXO4_HUMAN Forkhead box protein O4 (sprot)

description: A forkhead box protein O4 that is encoded in the genome of human.


MYOG_HUMAN Myogenin (sprot)

A myogenin that is encoded in the genome of human.


name: FADS2_HUMAN Acyl-CoA 6-desaturase (sprot)

description: An acyl-CoA 6-desaturase that is encoded in the genome of human.


rheumatic disorder

description: Inflammatory and degenerative diseases of connective tissue structures, such as arthritis.


psychotic disorder

description: An abnormal condition of the mind that involves a loss of contact with reality. People experiencing psychosis may exhibit personality changes and thought disorder. Depending on its severity, this may be accompanied by unusual or bizarre behavior, as well as difficulty with social interaction and impairment in carrying out daily life activities.


Hypomagnesemia

description: An abnormally decreased magnesium concentration in the blood.


pyridoxal 5-phosphate

The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.


LIMK2_HUMAN LIM domain kinase 2 (sprot)

A LIM domain kinase 2 that is encoded in the genome of human.


name: RAB7B_HUMAN Ras-related protein Rab-7b (sprot)

description: A Ras-related protein Rab-7b that is encoded in the genome of human.


methylmalonic acidemia

description: A rare autosomal recessive inherited disorder caused by mutations of the MUT, MMAA, MMAB, MMADHC, and MCEE genes. It is characterized by abnormalities in the metabolism of lipids and proteins. Signs and symptoms usually appear early in life and vary from mild to life threatening. They include vomiting, dehydration, hypotonia, developmental delays, hepatomegaly, lethargy, intellectual disabilities, and chronic kidney disease.


PRTN3_HUMAN Myeloblastin (sprot)

A myeloblastin that is encoded in the genome of human.


GINSENOSIDE RB2

A ginsenoside found in Panax ginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 3 and 20 have been converted to the corresponding beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside and alpha-L-arabinopyranosyl-(1->6)-beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.


CP1A1_HUMAN Cytochrome P450 1A1 (sprot)

A cytochrome P450 1A1 that is encoded in the genome of human.


dabigatran

An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amoino group of N-pyridin-2-yl-beta-alanine. The active metabolite of the prodrug  dabigatran etexilate, it acts as an anticoagulant which is used for the prevention of stroke and systemic embolism.


name: PRGC2_HUMAN Peroxisome proliferator-activated receptor gamma coactivator 1-beta (sprot)

description: A peroxisome proliferator-activated receptor gamma coactivator 1-beta that is encoded in the genome of human.


name: TAP1_HUMAN Antigen peptide transporter 1 (sprot)

description: An antigen peptide transporter 1 that is encoded in the genome of human.


name: RA51C_HUMAN DNA repair protein RAD51 homolog 3 (sprot)

description: A DNA repair protein RAD51 homolog 3 that is encoded in the genome of human.


name: PURB_HUMAN Transcriptional regulator protein Pur-beta (sprot)

description: A transcriptional activator protein Pur-beta that is encoded in the genome of human.


gastroenteritis

description: An inflammatory disorder that affects the upper and lower gastrointestinal tract. Most commonly, this is attributed to viruses; however bacteria, parasites or adverse reactions can also be the culprit. Symptoms include acute diarrhea and vomiting.


name: AVR2B_HUMAN Activin receptor type-2B (sprot)

description: An activin receptor type-2B that is encoded in the genome of human.


metrifonate

A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.


isolated cerebellar hypoplasia/agenesis

description: Hypoplasia of the cerebellum that is associated with inherited metabolic disorders and neurodegenerative disorders. Signs and symptoms include mental and developmental delays, walking and balance difficulties, floppy muscle tone, and seizures.


Lymphadenopathy

description: Enlargment (swelling) of a lymph node.


name: UBP22_HUMAN Ubiquitin carboxyl-terminal hydrolase 22 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 22 that is encoded in the genome of human.


name: S39A9_HUMAN Zinc transporter ZIP9 (sprot)

description: A zinc transporter ZIP9 that is encoded in the genome of human.


name: EAA3_HUMAN Excitatory amino acid transporter 3 (sprot)

description: An excitatory amino acid transporter 3 that is encoded in the genome of human.


phosphatidylserine (18:1/20:4)

A phosphatidylserine 38:5 in which the acyl group at C-1 contains 18 carbons and 1 double bond while that at C-2 contains 20 carbons and 4 double bonds.


name: PDCD1_HUMAN Programmed cell death protein 1 (sprot)

description: A programmed cell death protein 1 that is encoded in the genome of human.


name: CP27A_HUMAN Sterol 26-hydroxylase, mitochondrial (sprot)

description: A cytochrome P450 27, mitochondrial that is encoded in the genome of human.


vardenafil

The sulfonamide resulting from formal condensation of the sulfo group of 4-ethoxy-3-(5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one-2-yl)benzenesulfonic acid and the secondary amino group of 4-ethylpiperazine.


name: AMGO2_HUMAN Amphoterin-induced protein 2 (sprot)

description: An amphoterin-induced protein 2 that is encoded in the genome of human.


name: MAP2_HUMAN Methionine aminopeptidase 2 (sprot)

description: A methionine aminopeptidase 2 that is encoded in the genome of human.


reactive arthritis

description: Reactive arthritis (ReA) is an autoimmune disorder belonging to the group of seronegative spondyloarthropathies and is characterized by the classic triad of arthritis, urethritis and conjunctivitis.


name: STN1_HUMAN CST complex subunit STN1 (sprot)

description: An oligonucleotide/oligosaccharide-binding fold-containing protein 1 that is encoded in the genome of human.


MEN1_HUMAN Menin (sprot)

A menin that is encoded in the genome of human.


name: SC6A1_HUMAN Sodium- and chloride-dependent GABA transporter 1 (sprot)

description: A sodium- and chloride-dependent GABA transporter 1 that is encoded in the genome of human.


selenomethionine

The L-enantiomer of selenomethionine.


name: SHH_HUMAN Sonic hedgehog protein (sprot)

description: A sonic hedgehog protein that is encoded in the genome of human.


name: FSTL3_HUMAN Follistatin-related protein 3 (sprot)

description: A follistatin-related protein 3 that is encoded in the genome of human.


Mediastinal lymphadenopathy

description: Swelling of lymph nodes within the mediastinum, the central compartment of the thoracic cavities that contains the heart and the great vessels, the esophagus, and trachea and other structures including lymph nodes.


indisulam

A chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development.


name: myelodysplastic syndrome with excess blasts-2

description: A myelodysplastic syndrome defined by 10-19% blasts in the bone marrow or 5-19% blasts in the blood and <10% blasts in the bone marrow. Approximately 33% of cases progress to acute leukemia. The prognosis is usually poor. (WHO)


name: HPBP1_HUMAN Hsp70-binding protein 1 (sprot)

description: An Hsp70-binding protein 1 that is encoded in the genome of human.


seasonal allergic rhinitis

description: Allergic rhinitis caused by outdoor allergens.


thyroid cancer

description: A malignant neoplasm involving the thyroid gland


beta thalassemia

description: Beta-thalassemia (BT) is characterized by deficiency (Beta+) or absence (Beta0) of synthesis of the beta globin chains of hemoglobin (Hb).


name: NEUL1_HUMAN E3 ubiquitin-protein ligase NEURL1 (sprot)

description: An E3 ubiquitin-protein ligase NEURL1 that is encoded in the genome of human.


CTND2_HUMAN Catenin delta-2 (sprot)

A catenin delta-2 that is encoded in the genome of human.


colonic disorder

description: Pathological processes in the colon region of the large intestine (intestine, large).


Gallbladder dyskinesia

description: Reduced motility of the gallbladder with reduced emptying fraction.


name: HXA11_HUMAN Homeobox protein Hox-A11 (sprot)

description: A homeobox protein Hox-A11 that is encoded in the genome of human.


name: DAP1_HUMAN Death-associated protein 1 (sprot)

description: A death-associated protein 1 that is encoded in the genome of human.


cabazitaxel

A tetracyclic diterpenoid that is 10-deacetylbaccatin III having O-methyl groups attached at positions 7 and 10 as well as an O-(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl group attached at position 13. Acts as a microtubule inhibitor, binds tubulin and promotes microtubule assembly and simultaneously inhibits disassembly.


name: ESRP1_HUMAN Epithelial splicing regulatory protein 1 (sprot)

description: An epithelial splicing regulatory protein 1 that is encoded in the genome of human.


name: LTOR2_HUMAN Ragulator complex protein LAMTOR2 (sprot)

description: A ragulator complex protein LAMTOR2 that is encoded in the genome of human.


name: PIF1_HUMAN ATP-dependent DNA helicase PIF1 (sprot)

description: An ATP-dependent DNA helicase PIF1 that is encoded in the genome of human.


name: BRCA2_HUMAN Breast cancer type 2 susceptibility protein (sprot)

description: A breast cancer type 2 susceptibility protein that is encoded in the genome of human.


name: NU2M_HUMAN NADH-ubiquinone oxidoreductase chain 2 (sprot)

description: An NADH-ubiquinone oxidoreductase chain 2 that is encoded in the genome of human.


T-cell leukemia

description: A malignant disease of the T-lymphocytes in the bone marrow, thymus, and/or blood.


ANGP2_HUMAN Angiopoietin-2 (sprot)

An angiopoietin-2 that is encoded in the genome of human.


interstitial nephritis

description: Inflammation of the renal tubules and supporting tissues of the kidney.


name: PMS1_HUMAN PMS1 protein homolog 1 (sprot)

description: A PMS1 protein homolog 1 that is encoded in the genome of human.


name: FGR_HUMAN Tyrosine-protein kinase Fgr (sprot)

description: A tyrosine-protein kinase Fgr that is encoded in the genome of human.


name: TFEC_HUMAN Transcription factor EC (sprot)

description: A transcription factor EC that is encoded in the genome of human.


name: ABCG1_HUMAN ATP-binding cassette sub-family G member 1 (sprot)

description: An ATP-binding cassette sub-family G member 1 that is encoded in the genome of human.


name: undifferentiated carcinoma of nasopharynx

description: A undifferentiated carcinoma that involves the nasopharynx.


name: CSKP_HUMAN Peripheral plasma membrane protein CASK (sprot)

description: A peripheral plasma membrane protein CASK that is encoded in the genome of human.


aripiprazole

An N-arylpiperazine that is piperazine substituted by a 4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl group at position 1 and by a 2,3-dichlorophenyl group at position 4. It is an antipsychotic drug used for the treatment of Schizophrenia, and other mood disorders.


ITB3_HUMAN Integrin beta-3 (sprot)

An integrin beta-3 that is encoded in the genome of human.


acute promyelocytic leukemia

description: An aggressive form of acute myeloid leukemia (AML), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells. APL manifests with easy bruising, hemorrhagic diathesis and fatigue.


name: PLD3_HUMAN 5'-3' exonuclease PLD3 (sprot)

description: A 5'-3' exonuclease PLD3 that is encoded in the genome of human.


iohexol

A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.


NGB_HUMAN Neuroglobin (sprot)

A neuroglobin that is encoded in the genome of human.


name: RHBL2_HUMAN Rhomboid-related protein 2 (sprot)

description: A rhomboid-related protein 2 that is encoded in the genome of human.


name: TCL1A_HUMAN T-cell leukemia/lymphoma protein 1A (sprot)

description: A T-cell leukemia/lymphoma protein 1A that is encoded in the genome of human.


DLL3_HUMAN Delta-like protein 3 (sprot)

A delta-like protein 3 that is encoded in the genome of human.


NGN2_HUMAN Neurogenin-2 (sprot)

A neurogenin-2 that is encoded in the genome of human.


MTG16_HUMAN Protein CBFA2T3 (sprot)

A protein CBFA2T3 that is encoded in the genome of human.


respiratory failure

description: The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function.


ITA2_HUMAN Integrin alpha-2 (sprot)

An integrin alpha-2 that is encoded in the genome of human.


taurochenodeoxycholic acid

A bile acid taurine conjugate of  chenodeoxycholic acid.


name: FCG3B_HUMAN Low affinity immunoglobulin gamma Fc region receptor III-B (sprot)

description: A low affinity immunoglobulin gamma Fc region receptor III-B that is encoded in the genome of human.


ITA2B_HUMAN Integrin alpha-IIb (sprot)

An integrin alpha-IIb that is encoded in the genome of human.


CUL4A_HUMAN Cullin-4A (sprot)

A cullin-4A that is encoded in the genome of human.


chronic meningitis

description: Chronic form of meningitis (disease).


head and neck squamous cell carcinoma

description: A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands.


name: HEXB_HUMAN Beta-hexosaminidase subunit beta (sprot)

description: A beta-hexosaminidase subunit beta that is encoded in the genome of human.


social phobia

description: An anxiety disorder characterized by an intense, irrational fear of one or more social or performance situations in which the individual believes that he or she will be scrutinized by others. Exposure to social situations immediately provokes an anxiety response. In adults, the social phobia is recognized as excessive or unreasonable.


obstructive jaundice

description: A finding indicating increased bilirubin levels in the blood and urine, due to intrahepatic or extrahepatic obstruction of the biliary system.


name: CCR3_HUMAN C-C chemokine receptor type 3 (sprot)

description: A C-C chemokine receptor type 3 that is encoded in the genome of human.


name: PSD10_HUMAN 26S proteasome non-ATPase regulatory subunit 10 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 10 that is encoded in the genome of human.


PSILOCYBINE

A tryptamine alkaloid that is N,N-dimethyltryptamine carrying an additional phosphoryloxy substituent at position 4. The major hallucinogenic alkaloid isolated from Psilocybe mushrooms (also known as Teonanacatl or "magic mushrooms").


Asthenia

description: A state characterized by a feeling of weakness and loss of strength leading to a generalized weakness of the body.


AURKB_HUMAN Aurora kinase B (sprot)

An aurora kinase B that is encoded in the genome of human.


gentian violet

An iminium ion that is malachite green cation in which the hydrogen at the para- psition of the monosubstituted phenyl group is replaced by a dimethylamino group.


name: NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (sprot)

description: A nuclear receptor subfamily 1 group I member 2 that is encoded in the genome of human.


name: I4E1B_HUMAN Eukaryotic translation initiation factor 4E type 1B (sprot)

description: A eukaryotic translation initiation factor 4E type 1B that is encoded in the genome of human.


cycloheximide

A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon  bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.


name: LRRF2_HUMAN Leucine-rich repeat flightless-interacting protein 2 (sprot)

description: A leucine-rich repeat flightless-interacting protein 2 that is encoded in the genome of human.


name: PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (sprot)

description: A peroxisome proliferator-activated receptor alpha that is encoded in the genome of human.


staphylococcal scalded skin syndrome

description: A blistering skin disorder caused by exfoliative toxins produced by Staphylococcus aureus infection. The toxins cause the formation of bullae and diffuse skin desquamation. The lesions may be localized or generalized, far away from the initial site of infection.


LACTULOSE

A synthetic galactosylfructose disaccharide used in the treatment of constipation and hepatic encephalopathy.


name: LBX1_HUMAN Transcription factor LBX1 (sprot)

description: A transcription factor LBX1 that is encoded in the genome of human.


name: GROA_HUMAN Growth-regulated alpha protein (sprot)

description: A growth-regulated alpha protein that is encoded in the genome of human.


name: KLRB1_HUMAN Killer cell lectin-like receptor subfamily B member 1 (sprot)

description: A killer cell lectin-like receptor subfamily B member 1 that is encoded in the genome of human.


guanidine

An aminocarboxamidine, the parent compound of the guanidines.


diversion colitis

description: A colitis which can occur as a complication of ileostomy or colostomy.


gastric adenocarcinoma

description: A carcinoma that arises from glandular epithelial cells of the stomach


adrenal gland pheochromocytoma

description: A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system that secretes catecholamines. It arises from the chromaffin cells of the adrenal medulla. Clinical presentation includes headaches, palpitations, chest and abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic nesting (zellballen) growth pattern is usually seen. Other growth patterns including trabecular pattern may also be present.


Crohn disease

description: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.


name: UBE2A_HUMAN Ubiquitin-conjugating enzyme E2 A (sprot)

description: A ubiquitin-conjugating enzyme E2 A that is encoded in the genome of human.


name: GFRA1_HUMAN GDNF family receptor alpha-1 (sprot)

description: A GDNF family receptor alpha-1 that is encoded in the genome of human.


NECT4_HUMAN Nectin-4 (sprot)

A nectin-4 that is encoded in the genome of human.


gallic acid

A trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5.


name: HAVR1_HUMAN Hepatitis A virus cellular receptor 1 (sprot)

description: A hepatitis A virus cellular receptor 1 that is encoded in the genome of human.


name: FAF1_HUMAN FAS-associated factor 1 (sprot)

description: A FAS-associated factor 1 that is encoded in the genome of human.


aortic atherosclerosis

description: A atherosclerosis that involves the aorta.


name: CP27B_HUMAN 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (sprot)

description: A 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial that is encoded in the genome of human.


name: GCFC2_HUMAN Intron Large complex component GCFC2 (sprot)

description: An intron Large complex component GCFC2 that is encoded in the genome of human.


name: DLX1_HUMAN Homeobox protein DLX-1 (sprot)

description: A homeobox protein DLX-1 that is encoded in the genome of human.


name: SLU7_HUMAN Pre-mRNA-splicing factor SLU7 (sprot)

description: A pre-mRNA-splicing factor SLU7 that is encoded in the genome of human.


maxillary sinus squamous cell carcinoma

description: A squamous cell carcinoma that arises from the mucosal epithelial surface of the maxillary sinus. Patients may present with nasal fullness, obstruction, and/or epistaxis.


reserpine

An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.


name: TET1_HUMAN Methylcytosine dioxygenase TET1 (sprot)

description: A methylcytosine dioxygenase TET1 that is encoded in the genome of human.


name: IRS1_HUMAN Insulin receptor substrate 1 (sprot)

description: An insulin receptor substrate 1 that is encoded in the genome of human.


name: HDBP1_HUMAN Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (sprot)

description: A glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 that is encoded in the genome of human.


name: TUSC2_HUMAN Tumor suppressor candidate 2 (sprot)

description: A tumor suppressor candidate 2 that is encoded in the genome of human.


COIL_HUMAN Coilin (sprot)

A coilin that is encoded in the genome of human.


name: CYFP2_HUMAN Cytoplasmic FMR1-interacting protein 2 (sprot)

description: A cytoplasmic FMR1-interacting protein 2 that is encoded in the genome of human.


LEG12_HUMAN Galectin-12 (sprot)

A galectin-12 that is encoded in the genome of human.


TEMPOL

A member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties.


AQP2_HUMAN Aquaporin-2 (sprot)

An aquaporin-2 that is encoded in the genome of human.


rivaroxaban

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-chlorothiophene-2-carboxylic acid with the amino group of 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one. An anticoagulant used for prophylaxis of venous thromboembolism in patients with knee or hip replacement surgery.


vitamin B12 deficiency

description: A disease characterized by low serum levels of vitamin B12, either inherited or acquired.


name: nephrotic syndrome of childhood - steroid sensitive

description: Nephrotic syndrome, occurring in the pediatric population, characterized by the normalization of proteinuria with the administration of corticosteroids.


name: KCNN4_HUMAN Intermediate conductance calcium-activated potassium channel protein 4 (sprot)

description: An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of human.


name: KDM5A_HUMAN Lysine-specific demethylase 5A (sprot)

description: A lysine-specific demethylase 5A that is encoded in the genome of human.


name: RS3_HUMAN Small ribosomal subunit protein uS3 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS3 that is encoded in the genome of human.


name: HXB4_HUMAN Homeobox protein Hox-B4 (sprot)

description: A homeobox protein Hox-B4 that is encoded in the genome of human.


Giant cell hepatitis

description: Chronic hepatitis characterized by parenchymal inflammation with formation of large multinucleated hepatocytes in response to a variety of insults to the liver.


phosphatidylserine (18:0/20:5)

A phosphatidylserine 38:5 in which the acyl group at C-1 contains 18 carbons and no double bonds while that at C-2 contains 20 carbons and 5 double bonds.


hemophilia

description: Hemophilia is a genetic disorder characterized by spontaneous hemorrhage or prolonged bleeding due to factor VIII or IX deficiency.


name: S1PR3_HUMAN Sphingosine 1-phosphate receptor 3 (sprot)

description: A sphingosine 1-phosphate receptor 3 that is encoded in the genome of human.


name: BAX_HUMAN Apoptosis regulator BAX (sprot)

description: An apoptosis regulator BAX that is encoded in the genome of human.


CAD13_HUMAN Cadherin-13 (sprot)

A cadherin-13 that is encoded in the genome of human.


AURKA_HUMAN Aurora kinase A (sprot)

An aurora kinase A that is encoded in the genome of human.


fluoxetine hydrochloride

A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine hydrochloride. A selective serotonin reuptake inhibitor (SSRI), it is used for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.


name: OLIG2_HUMAN Oligodendrocyte transcription factor 2 (sprot)

description: An oligodendrocyte transcription factor 2 that is encoded in the genome of human.


name: CTBP2_HUMAN C-terminal-binding protein 2 (sprot)

description: A C-terminal-binding protein 2 that is encoded in the genome of human.


name: G45IP_HUMAN Large ribosomal subunit protein mL64 (sprot)

description: A large ribosomal subunit protein mL64 that is encoded in the genome of human.


name: SNF5_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (sprot)

description: A SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 that is encoded in the genome of human.


cobalt dichloride

A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.


CD9_HUMAN CD9 antigen (sprot)

A CD9 molecule that is encoded in the genome of human.


adapalene

A naphthoic acid that is CD437 in which the phenolic hydroxy group has been converted to its methyl ether.


name: epidermolytic palmoplantar keratoderma, 1

description: A genetic skin disorder caused by mutations in the KRT9 gene. It is characterized by hyperkeratosis in the palms and soles resulting in abnormal thickening of the skin in these areas.


name: IEX1_HUMAN Radiation-inducible immediate-early gene IEX-1 (sprot)

description: A radiation-inducible immediate-early gene IEX-1 that is encoded in the genome of human.


MYH1_HUMAN Myosin-1 (sprot)

A myosin-1 that is encoded in the genome of human.


name: PRD16_HUMAN Histone-lysine N-methyltransferase PRDM16 (sprot)

description: A histone-lysine N-methyltransferase PRDM16 that is encoded in the genome of human.


PLIN4_HUMAN Perilipin-4 (sprot)

A perilipin-4 that is encoded in the genome of human.


name: BNI3L_HUMAN BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (sprot)

description: A BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like that is encoded in the genome of human.


name: BRAF_HUMAN Serine/threonine-protein kinase B-raf (sprot)

description: A B-Raf proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human.


name: TEX14_HUMAN Inactive serine/threonine-protein kinase TEX14 (sprot)

description: A testis-expressed protein 14 that is encoded in the genome of human.


name: DPPA3_HUMAN Developmental pluripotency-associated protein 3 (sprot)

description: A developmental pluripotency-associated protein 3 that is encoded in the genome of human.


name: PCKGC_HUMAN Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (sprot)

description: A phosphoenolpyruvate carboxykinase, cytosolic [GTP] that is encoded in the genome of human.


piperine

A N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum.


chlorambucil

A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.


agammaglobulinemia

description: A decreased level of serum immunoglobulins. It may be inherited or acquired. It is caused by decreased or inefficient production of immunoglobulins from B cells or by a decrease in the numbers of B cells themselves. Low levels of immunoglobulins will affect the immune system's ability to combat bacterial infection. Supplementation of immunoglobulins is needed to prevent worsening outcomes.


AMPELOPSIN

An optically active form of dihydromyricetin having (2R,3R)-configuration.


name: IMA4_HUMAN Importin subunit alpha-4 (sprot)

description: An importin subunit alpha-4 that is encoded in the genome of human.


name: IMA3_HUMAN Importin subunit alpha-3 (sprot)

description: An importin subunit alpha-3 that is encoded in the genome of human.


name: ILEU_HUMAN Leukocyte elastase inhibitor (sprot)

description: A leukocyte elastase inhibitor that is encoded in the genome of human.


name: MYEF2_HUMAN Myelin expression factor 2 (sprot)

description: A myelin expression factor 2 that is encoded in the genome of human.


name: BHE40_HUMAN Class E basic helix-loop-helix protein 40 (sprot)

description: A class E basic helix-loop-helix protein 40 that is encoded in the genome of human.


pemafibrate

A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-amine in which the amino hydrogens are replaced by 3-[(1R)-1-carboxypropoxy]benzyl and 3-(4-methoxyphenoxy)propyl groups. It is a selective peroxisome proliferator-activated receptor (PPAR)-alpha agonist that is used for the treatment of hyperlipidaemia.


UXT_HUMAN Protein UXT (sprot)

A protein UXT that is encoded in the genome of human.


name: RS5_HUMAN Small ribosomal subunit protein uS7 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS7 that is encoded in the genome of human.


cefotaxime

A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.


name: TRBC2_HUMAN T cell receptor beta constant 2 (sprot)

description: A T cell receptor beta constant 2 that is encoded in the genome of human.


name: TVB28_HUMAN T cell receptor beta variable 28 (sprot)

description: A protein that is a translation product of the TRBV28 gene in human.


oleate

A C18, long straight-chain monounsaturated fatty acid anion; and the conjugate base of oleic acid, arising from deprotonation of the carboxylic acid group.


PLIN5_HUMAN Perilipin-5 (sprot)

A perilipin-5 that is encoded in the genome of human.


name: SC5A1_HUMAN Sodium/glucose cotransporter 1 (sprot)

description: A sodium/glucose cotransporter 1 that is encoded in the genome of human.


name: SUV91_HUMAN Histone-lysine N-methyltransferase SUV39H1 (sprot)

description: A histone-lysine N-methyltransferase SUV39H1 that is encoded in the genome of human.


name: CCNE2_HUMAN G1/S-specific cyclin-E2 (sprot)

description: A G1/S-specific cyclin-E2 that is encoded in the genome of human.


name: Increased circulating androgen concentration

description: An elevation of the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone.


artemisinin

A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.


drug-induced liver injury

description: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to acute liver failure, caused by drugs, drug metabolites, and chemicals from the environment.


short-chain fatty acid

An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid.


name: SMN_HUMAN Survival motor neuron protein (sprot)

description: A survival motor neuron protein that is encoded in the genome of human.


genistein

A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.


name: MKRN3_HUMAN Probable E3 ubiquitin-protein ligase makorin-3 (sprot)

description: A makorin-3 that is encoded in the genome of human.


name: AFG32_HUMAN Mitochondrial inner membrane m-AAA protease component AFG3L2 (sprot)

description: An AFG3-like protein 2 that is encoded in the genome of human.


METHYL VANILLATE

A benzoate ester that is the methyl ester of  vanillic acid.


A nitro fatty acid that is (9E)-octadec-9-enoic (elaidic) acid substituted by a nitro group at position 10.


secondary malignant neoplasm

description: A malignant neoplasm that arises from a pre-existing lower grade lesion, or as a result of a primary lesion that has spread to secondary sites, or due to a complication of a cancer treatment.


CYS1_HUMAN Cystin-1 (sprot)

A cystin-1 that is encoded in the genome of human.


formoterol

A racemate consisting of equal amounts of arformoterol (the active enantiomer) and (S,S)-formoterol (the inactive enantiomer). Its fumaric acid salt is used as a direct-acting sympathomimetic and bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema).


name: IRF7_HUMAN Interferon regulatory factor 7 (sprot)

description: An interferon regulatory factor 7 that is encoded in the genome of human.


name: SL9A9_HUMAN Sodium/hydrogen exchanger 9 (sprot)

description: A sodium/hydrogen exchanger 9 that is encoded in the genome of human.


retinal artery occlusion

description: An occlusion of the retinal artery.


name: chronic lymphocytic leukemia/small lymphocytic lymphoma

description: An indolent, mature B-cell neoplasm composed of small, round B-lymphocytes. When the bone marrow and peripheral blood are involved, the term chronic lymphocytic leukemia is used. The term small lymphocytic lymphoma is restricted to cases which do not show leukemic involvement of the bone marrow and peripheral blood.


pomalidomide

An aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies.


lopinavir

A dicarboxylic acid diamide that is amphetamine is substituted on nitrogen by a (2,6-dimethylphenoxy)acetyl group and on the carbon alpha- to nitrogen by a (1S,3S)-1-hydroxy-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1-yl)butanoyl]amino}-4-phenylbutyl group. An antiretroviral of the protease inhibitor class, it is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir.


cholestasis

description: Impairment of the bile flow caused by obstruction within the liver, or outside the liver in the bile duct system.


A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.


name: CXL10_HUMAN C-X-C motif chemokine 10 (sprot)

description: A C-X-C motif chemokine 10 that is encoded in the genome of human.


name: HDA11_HUMAN Histone deacetylase 11 (sprot)

description: A histone deacetylase 11 that is encoded in the genome of human.


name: SNRK_HUMAN SNF-related serine/threonine-protein kinase (sprot)

description: An SNF-related serine/threonine-protein kinase that is encoded in the genome of human.


name: FIG4_HUMAN Polyphosphoinositide phosphatase (sprot)

description: A polyphosphoinositide phosphatase that is encoded in the genome of human.


dehydrodiconiferyl alcohol

A guaiacyl lignin obtained by cyclodimerisation of coniferol.


cobimetinib

A member of the class of N-acylazetidines obtained by selective formal condensation of the carboxy group of 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid with the secondary amino group from the azetidine ring of 3-[(2S)-piperidin-2-yl]azetidin-3-ol. An inhibitor of mitogen-activated protein kinase that is used (as its fumarate salt) in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma.


glycoprotein

A compound in which a carbohydrate component is covalently bound to a protein component.


PLEK_HUMAN Pleckstrin (sprot)

A pleckstrin that is encoded in the genome of human.


name: INSL6_HUMAN Insulin-like peptide INSL6 (sprot)

description: An insulin-like peptide INSL6 that is encoded in the genome of human.


name: IF4E_HUMAN Eukaryotic translation initiation factor 4E (sprot)

description: A eukaryotic translation initiation factor 4E that is encoded in the genome of human.


name: HGFL_HUMAN Hepatocyte growth factor-like protein (sprot)

description: A hepatocyte growth factor-like protein that is encoded in the genome of human.


vandetanib

A quinazoline that is 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline bearing additional methoxy and 4-bromo-2-fluorophenylamino substituents at positions 6 and 4 respectively. Used for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.


name: TRI22_HUMAN E3 ubiquitin-protein ligase TRIM22 (sprot)

description: An E3 ubiquitin-protein ligase TRIM22 that is encoded in the genome of human.


Hypoinsulinemia

description: A decreased concentration of insulin in the blood.


name: NEU1_HUMAN Oxytocin-neurophysin 1 (sprot)

description: An oxytocin-neurophysin 1 that is encoded in the genome of human.


name: MOGS_HUMAN Mannosyl-oligosaccharide glucosidase (sprot)

description: A mannosyl-oligosaccharide glucosidase that is encoded in the genome of human.


name: GBA1_HUMAN Lysosomal acid glucosylceramidase (sprot)

description: A lysosomal acid glucosylceramidase that is encoded in the genome of human.


MT1E_HUMAN Metallothionein-1E (sprot)

A metallothionein-1E that is encoded in the genome of human.


MT1G_HUMAN Metallothionein-1G (sprot)

A metallothionein-1G that is encoded in the genome of human.


deslanoside

A cardenolide glycoside that is lanatoside C with the acetoxy group replaced by a hydroxy group.


LEG1_HUMAN Galectin-1 (sprot)

A galectin-1 that is encoded in the genome of human.


pyridoxal

A pyridinecarbaldehyde that is pyridine-4-carbaldehyde bearing methyl, hydroxy and hydroxymethyl substituents at positions 2, 3 and 5 respectively. The 4-carboxyaldehyde form of vitamin B6, it is converted into pyridoxal phosphate, a coenzyme for the synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid.


Gaucher disease

description: Gaucher disease (GD) is a lysosomal storage disorder encompassing three main forms (types 1, 2 and 3), a fetal form and a variant with cardiac involvement (Gaucher disease - ophthalmoplegia - cardiovascular calcification or Gaucher-like disease).


name: GSK3A_HUMAN Glycogen synthase kinase-3 alpha (sprot)

description: A glycogen synthase kinase-3 alpha that is encoded in the genome of human.


myeloid leukemia

description: A clonal proliferation of myeloid cells and their precursors in the bone marrow, peripheral blood, and spleen. When the proliferating cells are immature myeloid cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating myeloid cells are neutrophils, it is called chronic myelogenous leukemia.


name: ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-2 that is encoded in the genome of human.


ketoprofen

An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.


fallopian tube cancer

description: A primary or metastatic malignant neoplasm that affects the fallopian tube. Representative examples include carcinoma, carcinosarcoma, and leiomyosarcoma.


IFNB_HUMAN Interferon beta (sprot)

An interferon beta 1 that is encoded in the genome of human.


betadex

A cyclodextrin composed of seven alpha-(1->4) linked D-glucopyranose units.


irinotecan

A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.


spermidine

A triamine that is the 1,5,10-triaza derivative of decane.


name: GTR2_HUMAN Solute carrier family 2, facilitated glucose transporter member 2 (sprot)

description: A solute carrier family 2, facilitated glucose transporter member 2 that is encoded in the genome of human.


name: AT8B1_HUMAN Phospholipid-transporting ATPase IC (sprot)

description: A phospholipid-transporting ATPase IC that is encoded in the genome of human.


name: MDR3_HUMAN Phosphatidylcholine translocator ABCB4 (sprot)

description: A phosphatidylcholine translocator ABCB4 that is encoded in the genome of human.


name: GBB3_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (sprot)

description: A guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 that is encoded in the genome of human.


name: TET2_HUMAN Methylcytosine dioxygenase TET2 (sprot)

description: A methylcytosine dioxygenase TET2 that is encoded in the genome of human.


name: SIN3A_HUMAN Paired amphipathic helix protein Sin3a (sprot)

description: A paired amphipathic helix protein Sin3a that is encoded in the genome of human.


name: GRB10_HUMAN Growth factor receptor-bound protein 10 (sprot)

description: A growth factor receptor-bound protein 10 that is encoded in the genome of human.


name: PHLA2_HUMAN Pleckstrin homology-like domain family A member 2 (sprot)

description: A pleckstrin homology-like domain family A member 2 that is encoded in the genome of human.


name: SCND3_HUMAN SCAN domain-containing protein 3 (sprot)

description: A SCAN domain-containing protein 3 that is encoded in the genome of human.


name: CD1D_HUMAN Antigen-presenting glycoprotein CD1d (sprot)

description: An antigen-presenting glycoprotein CD1d that is encoded in the genome of human.


name: NMDE3_HUMAN Glutamate receptor ionotropic, NMDA 2C (sprot)

description: A glutamate receptor ionotropic, NMDA 2C that is encoded in the genome of human.


name: CD69_HUMAN Early activation antigen CD69 (sprot)

description: A CD69 molecule that is encoded in the genome of human.


name: CXCR5_HUMAN C-X-C chemokine receptor type 5 (sprot)

description: A C-X-C chemokine receptor type 5 that is encoded in the genome of human.


artemether

An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.


name: MNX1_HUMAN Motor neuron and pancreas homeobox protein 1 (sprot)

description: A motor neuron and pancreas homeobox protein 1 that is encoded in the genome of human.


name: RDH10_HUMAN Retinol dehydrogenase 10 (sprot)

description: A retinol dehydrogenase 10 that is encoded in the genome of human.


name: FOXG1_HUMAN Forkhead box protein G1 (sprot)

description: A forkhead box protein G1 that is encoded in the genome of human.


name: CHAC1_HUMAN Glutathione-specific gamma-glutamylcyclotransferase 1 (sprot)

description: A glutathione-specific gamma-glutamylcyclotransferase 1 that is encoded in the genome of human.


name: HASP_HUMAN Serine/threonine-protein kinase haspin (sprot)

description: A serine/threonine-protein kinase haspin that is encoded in the genome of human.


hyperphosphatemia

description: Abnormally high level of phosphate in the blood.


diltiazem

A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.


chronic purulent otitis media

description: Otitis media that persists for at least six weeks, and that is associated with otorrhea through a perforated tympanic membrane.


desmoplastic small round cell tumor

description: Desmoplastic small round cell tumor (DSRCT) is an aggressive soft tissue cancer that typically arises in serous lined surfaces of the abdominal or pelvic peritoneum, and spreads to the omentum, lymph nodes and hematogenously disseminates especially to the liver. Extraserous primary location has been reported in exceptional cases.


name: SETX_HUMAN Probable helicase senataxin (sprot)

description: A probable helicase senataxin that is encoded in the genome of human.


enalapril

A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).


EPB41_HUMAN Protein 4.1 (sprot)

A protein 4.1 that is encoded in the genome of human.


lactose

A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.


name: FMR1_HUMAN Fragile X messenger ribonucleoprotein 1 (sprot)

description: A fragile X messenger ribonucleoprotein 1 that is encoded in the genome of human.


NLGN2_HUMAN Neuroligin-2 (sprot)

A neuroligin-2 that is encoded in the genome of human.


levofloxacin

An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase.


infectious otitis media

description: Inflammation of the anatomical structures of the middle ear secondary to an infectious process. Bacterial etiology is most common, but both viral and fungal pathogens are also possible. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever. In severe infections, inflammation and edema of the structures of the middle ear can lead to perforation of the tympanic membrane secondary to the buildup of pressure in the narrow space.


DEF5_HUMAN Defensin alpha 5 (sprot)

A protein that is a translation product of the DEFA5 gene in human.


ketanserin

A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.


name: MED4_HUMAN Mediator of RNA polymerase II transcription subunit 4 (sprot)

description: A mediator of RNA polymerase II transcription subunit 4 that is encoded in the genome of human.


name: FKB1A_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1A (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP1A that is encoded in the genome of human.


Middle East respiratory syndrome

description: A viral respiratory infection that is caused by the MERS coronavirus (MERS-CoV), which most often manifests with moderate to severe respiratory symptoms, including productive cough and shortness of breath, which can progress to pneumonia and acute respiratory distress syndrome.


RYR2_HUMAN Ryanodine receptor 2 (sprot)

A ryanodine receptor 2 that is encoded in the genome of human.


periprosthetic joint infection

description: A bacterial infection of the joint that is a complication occurring in 1% to 2% of primary arthroplasties.


P2RY2_HUMAN P2Y purinoceptor 2 (sprot)

A P2Y purinoceptor 2 that is encoded in the genome of human.


Primary hypothyroidism

description: A type of hypothyroidism that results from a defect in the thyroid gland.


name: EGR1_HUMAN Early growth response protein 1 (sprot)

description: An early growth response protein 1 that is encoded in the genome of human.


name: ACL6A_HUMAN Actin-like protein 6A (sprot)

description: An actin-like protein 6A that is encoded in the genome of human.


primitive neuroectodermal tumor

description: A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm constitutes the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems and includes some glial cell precursors.


cyclic GMP

A 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine.


NUCB2_HUMAN Nucleobindin-2 (sprot)

A nucleobindin-2 that is encoded in the genome of human.


name: PIM3_HUMAN Serine/threonine-protein kinase pim-3 (sprot)

description: A serine/threonine-protein kinase Pim-3 that is encoded in the genome of human.


LEP_HUMAN Leptin (sprot)

A leptin that is encoded in the genome of human.


name: SOCS3_HUMAN Suppressor of cytokine signaling 3 (sprot)

description: A suppressor of cytokine signaling 3 that is encoded in the genome of human.


PHOSPHATIDYL SERINE

A 3-sn-phosphatidyl L-serine in which the phosphatidyl acyl group at both positions 1 and 2 is stearoyl.


severe acute respiratory syndrome

description: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death.


colon carcinoma

description: A carcinoma that arises from epithelial cells of the colon


name: SMCA4_HUMAN Transcription activator BRG1 (sprot)

description: A transcription activator BRG1 that is encoded in the genome of human.


description: ALK-positive anaplastic large cell lymphoma (ALK+ ALCL) is a type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the expression of a protein called anaplastic lymphoma kinase (ALK).


name: GSTM3_HUMAN Glutathione S-transferase Mu 3 (sprot)

description: A glutathione S-transferase mu 3 that is encoded in the genome of human.


name: ALDR_HUMAN Aldo-keto reductase family 1 member B1 (sprot)

description: An aldo-keto reductase family 1 member B1 that is encoded in the genome of human.


estrone

A 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17.


name: DHB1_HUMAN 17-beta-hydroxysteroid dehydrogenase type 1 (sprot)

description: A 17-beta-hydroxysteroid dehydrogenase type 1 that is encoded in the genome of human.


medulloblastoma

description: A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, and medulloblastoma with extensive nodularity.


PIPECOLIC ACID

A piperidinemonocarboxylic acid in which the carboxy group is located at position C-2.


bladder adenocarcinoma

description: A carcinoma that arises from glandular epithelial cells of the urinary bladder


ISATIN

An indoledione that is the 2,3-diketo derivative of indole.


uterine cervix neoplasm

description: A neoplasm (disease) that involves the uterine cervix.


An ammonium ion that is the conjugate acid of (S)-1,2-distearoylphosphatidylethanolamine, arising from protonation of the amino group.


zinc diethyldithiocarbamate

A dithiocarbamate salt that is the zinc salt of diethyldithiocarbamic acid. It is an accelerator and activator for natural rubber.


ERUCIC ACID

A docosenoic acid having a cis- double bond at C-13. It is found particularly in brassicas - it is a major component of mustard and rapeseed oils and is produced by broccoli, Brussels sprouts, kale, and wallflowers.


CLD5_HUMAN Claudin-5 (sprot)

A claudin-5 that is encoded in the genome of human.


tranilast

An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group.


name: REV1_HUMAN DNA repair protein REV1 (sprot)

description: A DNA repair protein REV1 that is encoded in the genome of human.


name: SARM1_HUMAN NAD(+) hydrolase SARM1 (sprot)

description: An NAD(+) hydrolase SARM1 that is encoded in the genome of human.


name: DMBX1_HUMAN Diencephalon/mesencephalon homeobox protein 1 (sprot)

description: A diencephalon/mesencephalon homeobox protein 1 that is encoded in the genome of human.


name: HMX1_HUMAN Homeobox protein HMX1 (sprot)

description: A homeobox protein HMX1 that is encoded in the genome of human.


name: TRPC6_HUMAN Short transient receptor potential channel 6 (sprot)

description: A short transient receptor potential channel 6 that is encoded in the genome of human.


Juvenile cataract

description: A type of cataract that is not apparent at birth but that arises in childhood or adolescence.


candidemia

description: A form of invasive candidiasis where species of candida are present in the blood.


Cardiomegaly

description: Increased size of the heart, clinically defined as an increased transverse diameter of the cardiac silhouette that is greater than or equal to 50% of the transverse diameter of the chest (increased cardiothoracic ratio) on a posterior-anterior projection of a chest radiograph or a computed tomography.


name: VIP1_HUMAN Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (sprot)

description: An inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 that is encoded in the genome of human.


thiamine

A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.


name: TBX5_HUMAN T-box transcription factor TBX5 (sprot)

description: A T-box transcription factor TBX5 that is encoded in the genome of human.


name: ECM1_HUMAN Extracellular matrix protein 1 (sprot)

description: An extracellular matrix protein 1 that is encoded in the genome of human.


diphenoxylate

A piperidinecarboxylate ester that is the ethyl ester of difenoxin.


microscopic colitis

description: Inflammation of the colon that is only apparent by microscopic examination.


ADEFOVIR

A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.


phosphatidylethanolamine (16:0/16:1)

1,2-diacyl-sn-glycero-3-phosphoethanolamine  in which the acyl group at C-1 contains 16 carbons and no double bonds while that at C-2 contains 16 carbons and 1 double bond.


name: TGFB3_HUMAN Transforming growth factor beta-3 proprotein (sprot)

description: A TGF-beta 3 that is encoded in the genome of human.


name: RAD54_HUMAN DNA repair and recombination protein RAD54-like (sprot)

description: A DNA repair and recombination protein RAD54-like that is encoded in the genome of human.


name: IGF2_HUMAN Insulin-like growth factor II (sprot)

description: An insulin-like growth factor II that is encoded in the genome of human.


name: LT4R1_HUMAN Leukotriene B4 receptor 1 (sprot)

description: A leukotriene B4 receptor 1 that is encoded in the genome of human.


name: SPY1_HUMAN Protein sprouty homolog 1 (sprot)

description: A protein sprouty homolog 1 that is encoded in the genome of human.


L-cystine

The L-enantiomer of the sulfur-containing amino acid cystine.


name: RING2_HUMAN E3 ubiquitin-protein ligase RING2 (sprot)

description: An E3 ubiquitin-protein ligase RING2 that is encoded in the genome of human.


gastric carcinoma

description: A carcinoma that arises from epithelial cells of the stomach.


ajmaline

A monoterpenoid indole alkaloid that consists of ajmalan substituted at positions 17 and 21 by hydroxy groups.


tetralinoleoyl cardiolipin

A cardiolipin in which all four phosphatidyl acyl groups are specified as linoleoyl.


Barth syndrome

description: Barth syndrome (BTHS) is an inborn error of phospholipid metabolism characterized by dilated cardiomyopathy (DCM), skeletal myopathy, neutropenia, growth delay and organic aciduria.


name: ATPF1_HUMAN ATP synthase mitochondrial F1 complex assembly factor 1 (sprot)

description: An ATP synthase mitochondrial F1 complex assembly factor 1 that is encoded in the genome of human.


gestational trophoblastic neoplasm

description: A diverse group of pregnancy-related tumors characterized by excessive proliferation of trophoblasts. Representative examples include hydatidiform mole, gestational choriocarcinoma, and placental site trophoblastic tumor.


lithium citrate

A lithium salt that is the anhydrous form of the trilithium salt of citric acid. The tetrahydrate form is used as a source of lithium for the treatment of anxiety disorders, bipolar disorder, and depression.


AFG1L_HUMAN AFG1-like ATPase (sprot)

An AFG1-like ATPase that is encoded in the genome of human.


name: MPEG1_HUMAN Macrophage-expressed gene 1 protein (sprot)

description: A macrophage-expressed gene 1 protein that is encoded in the genome of human.


name: CAP1_HUMAN Adenylyl cyclase-associated protein 1 (sprot)

description: An adenylyl cyclase-associated protein 1 that is encoded in the genome of human.


QUINOLINIC ACID

A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.


name: NFAC3_HUMAN Nuclear factor of activated T-cells, cytoplasmic 3 (sprot)

description: A nuclear factor of activated T-cells, cytoplasmic 3 that is encoded in the genome of human.


COL11_HUMAN Collectin-11 (sprot)

A collectin-11 that is encoded in the genome of human.


interstitial lung disease

description: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of pulmonary alveoli that extends to the interstitium and beyond leading to diffuse pulmonary fibrosis. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.


ITAL_HUMAN Integrin alpha-L (sprot)

An integrin alpha-L that is encoded in the genome of human.


name: cyclin-dependent kinase inhibitor 2A isoform h5 (human)

description: A cyclin-dependent kinase inhibitor 2A isoform 5 that is encoded in the genome of human.


name: ATG3_HUMAN Ubiquitin-like-conjugating enzyme ATG3 (sprot)

description: A ubiquitin-like-conjugating enzyme ATG3 that is encoded in the genome of human.


renal tubule disorder

description: A disease that involves the renal tubule.


multiple organ dysfunction syndrome

description: The development of potentially reversible physiologic derangement involving two or more organ systems not involved in the disorder that resulted in intensive care unit (ICU) admission, and arising in the wake of a potentially life-threatening physiologic insult.


name: C1QL3_HUMAN Complement C1q-like protein 3 (sprot)

description: A complement C1q-like protein 3 that is encoded in the genome of human.


nicorandil

A pyrimidinecarboxamide that is nicotinamide in which one of the hydrogens attached to the carboxamide nitrogen is replaced by a 2-(nitrooxy)ethyl group. It has both nitrate-like and ATP-sensitive potassium channel activator properties, and is used for the prevention and treatment of angina pectoris.


name: IF2A_HUMAN Eukaryotic translation initiation factor 2 subunit 1 (sprot)

description: A eukaryotic translation initiation factor 2 subunit 1 that is encoded in the genome of human.


name: ALKB2_HUMAN DNA oxidative demethylase ALKBH2 (sprot)

description: A DNA oxidative demethylase ALKBH2 that is encoded in the genome of human.


PROSTAGLANDIN D2

A member of the class of  prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- stereoisomer).


CUL1_HUMAN Cullin-1 (sprot)

A fungal/metazoan cullin-1 that is encoded in the genome of human.


A nitroarene that is pyrene substituted at the 1-position by a nitro group. A by-product of combustion,  it is the predominant nitrated polycyclic aromatic hydrocarbon emitted in a diesel engine.


name: S27A1_HUMAN Long-chain fatty acid transport protein 1 (sprot)

description: A long-chain fatty acid transport protein 1 that is encoded in the genome of human.


name: THOC4_HUMAN THO complex subunit 4 (sprot)

description: A THO complex subunit 4 that is encoded in the genome of human.


name: IL6RB_HUMAN Interleukin-6 receptor subunit beta (sprot)

description: An interleukin-6 receptor subunit beta that is encoded in the genome of human.


cinaciguat

A benzoic acid that is 4-(aminomethyl)benzoic acid in which the amino group is substituted by 4-carboxybutyl and 2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl groups. It is a soluble guanylate cyclase activator, used for the treatment of acute decompensated heart failure.


veliparib

A benzimidazole substituted with a carbamoyl group at C-4 and a (2R)-2-methylpyrrolidin-2-yl moiety at C-2.  It is a potent, orally bioavailable PARP inhibitor.


name: TMX2_HUMAN Thioredoxin-related transmembrane protein 2 (sprot)

description: A thioredoxin-related transmembrane protein 2 that is encoded in the genome of human.


keratitis

description: A corneal disease that is characterized by inflammation of the cornea.


Facial edema

description: Swelling due to an excessive accumulation of fluid in facial tissues.


central nervous system disorder

description: A disease involving the central nervous system.


CRF_HUMAN Corticoliberin (sprot)

A corticoliberin that is encoded in the genome of human.


name: NELL2_HUMAN Protein kinase C-binding protein NELL2 (sprot)

description: A protein kinase C-binding protein NELL2 that is encoded in the genome of human.


TRFE_HUMAN Serotransferrin (sprot)

A serotransferrin that is encoded in the genome of human.


name: LIPR2_HUMAN Pancreatic lipase-related protein 2 (sprot)

description: A pancreatic lipase-related protein 2 that is encoded in the genome of human.


name: DGAT2_HUMAN Diacylglycerol O-acyltransferase 2 (sprot)

description: A diacylglycerol O-acyltransferase 2 that is encoded in the genome of human.


name: CLC7A_HUMAN C-type lectin domain family 7 member A (sprot)

description: A C-type lectin domain family 7 member A that is encoded in the genome of human.


IL22_HUMAN Interleukin-22 (sprot)

An interleukin-22 that is encoded in the genome of human.


retinal ischemia

description: A ischemic disease that involves the retina.


nabumetone

A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.


primary anetoderma

description: Primary anetoderma is a rare skin disease characterized by loss of elastin tissue resulting in localized areas of flaccid skin in the absence of a secondary cause.


canine osteosarcoma

description: An osteosarcoma of mesenchymal origin in a dog. It is the most common bone cancer in dogs, most often developing in the limbs of large or giant breed dogs. The morphologic and biologic behavior of canine osteosarcomas is similar to that of human osteosarcomas.


CD320_HUMAN CD320 antigen (sprot)

A CD320 molecule that is encoded in the genome of human.


name: ISG15_HUMAN Ubiquitin-like protein ISG15 (sprot)

description: A ubiquitin-like protein ISG15 that is encoded in the genome of human.


name: CDC20_HUMAN Cell division cycle protein 20 homolog (sprot)

description: A cell division cycle protein 20 homolog that is encoded in the genome of human.


name: PIP_HUMAN Prolactin-inducible protein (sprot)

description: A prolactin-inducible protein that is encoded in the genome of human.


name: IGHA2_HUMAN Immunoglobulin heavy constant alpha 2 (sprot)

description: An immunoglobulin heavy constant alpha 2 that is encoded in the genome of human.


methenamine

A polycyclic cage that is adamantane in which the carbon atoms at positions 1, 3, 5 and 7 are replaced by nitrogen atoms.


L-glucose

The L-enantiomer of aldehydo-glucose.


CD83_HUMAN CD83 antigen (sprot)

A CD83 molecule that is encoded in the genome of human.


esmolol

A racemate comprising equimolar amounts of (R)- and (S)-esmolol. A cardioselective and short-acting beta1 receptor blocker with rapid onset but lacking intrinsic sympathomimetic and membrane-stabilising properties, it is used as the hydrochloride salt in the management of supraventricular arrhythmias, and for the control of hypertension and tachycardia during surgery. While the S enantiomer possesses all of the heart rate control, both enantiomers contribute to lowering blood pressure.


name: ISK1_HUMAN Serine protease inhibitor Kazal-type 1 (sprot)

description: A serine protease inhibitor Kazal-type 1 that is encoded in the genome of human.


Pain

description: An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.


name: QCR2_HUMAN Cytochrome b-c1 complex subunit 2, mitochondrial (sprot)

description: A cytochrome b-c1 complex subunit 2, mitochondrial that is encoded in the genome of human.


name: COX41_HUMAN Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (sprot)

description: A cytochrome c oxidase subunit 4 isoform 1, mitochondrial that is encoded in the genome of human.


NGN1_HUMAN Neurogenin-1 (sprot)

A neurogenin-1 that is encoded in the genome of human.


name: ATP6_HUMAN ATP synthase subunit a (sprot)

description: An ATP synthase subunit a that is encoded in the genome of human.


name: SH22A_HUMAN SH2 domain-containing protein 2A (sprot)

description: An SH2 domain-containing protein 2A that is encoded in the genome of human.


memantine

A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.


name: IMPA2_HUMAN Inositol monophosphatase 2 (sprot)

description: An inositol monophosphatase 2 that is encoded in the genome of human.


name: MAN1_HUMAN Inner nuclear membrane protein Man1 (sprot)

description: An inner nuclear membrane protein Man1 that is encoded in the genome of human.


B Acute Lymphoblastic Leukemia

description: A type of ALL characterized by elevated levels of B-cell lymphoblasts in the bone marrow and the blood.


IL17F_HUMAN Interleukin-17F (sprot)

An interleukin-17F that is encoded in the genome of human.


trifluridine

A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis.


cytomegalovirus retinitis

description: Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. Cytomegalovirus retinitis is a major opportunistic infection in aids patients and can cause blindness.


ethacrynic acid

An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.


MDMA

A member of the class of  benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.


name: FCF1_HUMAN rRNA-processing protein FCF1 homolog (sprot)

description: An rRNA-processing protein FCF1 that is encoded in the genome of human.


MUC5A_HUMAN Mucin-5AC (sprot)

A mucin-5AC that is encoded in the genome of human.


name: CTRL_HUMAN Chymotrypsin-like protease CTRL-1 (sprot)

description: A chymotrypsin-like protease CTRL-1 that is encoded in the genome of human.


amlodipine

A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.


diacylglycerol (18:0/22:5/0:0)

A 1,2-diglyceride in which the fatty acyl groups at positions 1 and 2 are specified as C18:0 and C22:5 respectively.


name: DUS2_HUMAN Dual specificity protein phosphatase 2 (sprot)

description: A dual specificity protein phosphatase 2 that is encoded in the genome of human.


levofolinic acid

The pharmacologically active (6S)-stereoisomer of 5-formyltetrahydrofolic acid.


ornithosis

description: Disease caused by the Chlamydophila psittaci bacteria, usually transmitted from birds to humans.


name: LAT2_HUMAN Large neutral amino acids transporter small subunit 2 (sprot)

description: A large neutral amino acids transporter small subunit 2 that is encoded in the genome of human.


terbutaline

A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.


name: MARH1_HUMAN E3 ubiquitin-protein ligase MARCHF1 (sprot)

description: An E3 ubiquitin-protein ligase MARCHF1 that is encoded in the genome of human.


name: JDP2_HUMAN Jun dimerization protein 2 (sprot)

description: A Jun dimerization protein 2 that is encoded in the genome of human.


name: CCN6_HUMAN Cellular communication network factor 6 (sprot)

description: A cellular communication network factor 6 that is encoded in the genome of human.


name: STRAP_HUMAN Serine-threonine kinase receptor-associated protein (sprot)

description: A serine-threonine kinase receptor-associated protein that is encoded in the genome of human.


name: PO4F1_HUMAN POU domain, class 4, transcription factor 1 (sprot)

description: A POU domain, class 4, transcription factor 1 that is encoded in the genome of human.


triamcinolone acetonide

A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.


myelitis

description: An inflammatory process affecting the spinal cord. Causes include viral infections, autoimmune disorders, vascular disorders, and toxic agents. Symptoms include weakness, paresthesia, sensory loss, pain, and incontinence.


name: CNR2_HUMAN Cannabinoid receptor 2 (sprot)

description: A cannabinoid receptor 2 that is encoded in the genome of human.


nipecotic acid

A piperidinemonocarboxylic acid that is piperidine in which one of the hydrogens at position 3 is substituted by a carboxylic acid group.


ANETHOLE

The trans-stereoisomer of anethole.


name: AGRG1_HUMAN Adhesion G-protein coupled receptor G1 (sprot)

description: An adhesion G-protein coupled receptor G1 that is encoded in the genome of human.


phenylbutyrate

A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4.  It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.


Fabry disease

description: Fabry disease (FD) is a progressive, inherited, multisystemic lysosomal storage disease characterized by specific neurological, cutaneous, renal, cardiovascular, cochleo-vestibular and cerebrovascular manifestations.


DCTN3_HUMAN Dynactin subunit 3 (sprot)

A dynactin subunit 3 that is encoded in the genome of human.


name: IFIT1_HUMAN Interferon-induced protein with tetratricopeptide repeats 1 (sprot)

description: An interferon-induced protein with tetratricopeptide repeats 1 that is encoded in the genome of human.


propafenone

An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.


name: GRM3_HUMAN Metabotropic glutamate receptor 3 (sprot)

description: A metabotropic glutamate receptor 3 that is encoded in the genome of human.


name: RMI1_HUMAN RecQ-mediated genome instability protein 1 (sprot)

description: A RecQ-mediated genome instability protein 1 that is encoded in the genome of human.


anastrozole

A 1,2,4-triazole compound having a 3,5-bis(2-cyano-2-propyl)benzyl group at the 1-position.


retinal vasculitis

description: Inflammation of the retinal vasculature with various causes including infectious disease; lupus erythematosus, systemic; multiple sclerosis; behcet syndrome; and chorioretinitis.


STON1_HUMAN Stonin-1 (sprot)

A stonin-1 that is encoded in the genome of human.


A member of the class of 2-aminopurines that is 2-aminopurine which is substituted by a chlorine at position 6 and by a (4-methoxy-3,5-dimethylpyridin-2-yl)methyl group at position 9.


name: PHX2B_HUMAN Paired mesoderm homeobox protein 2B (sprot)

description: A paired mesoderm homeobox protein 2B that is encoded in the genome of human.


name: PK3CD_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (sprot)

description: A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform that is encoded in the genome of human.


name: RGS16_HUMAN Regulator of G-protein signaling 16 (sprot)

description: A regulator of G-protein signaling 16 that is encoded in the genome of human.


name: ACACB_HUMAN Acetyl-CoA carboxylase 2 (sprot)

description: An acetyl-CoA carboxylase 2 that is encoded in the genome of human.


name: ZDHC1_HUMAN Palmitoyltransferase ZDHHC1 (sprot)

description: A palmitoyltransferase ZDHHC1 that is encoded in the genome of human.


glutaral

A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.


name: ATS5_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 5 (sprot)

description: An a disintegrin and metalloproteinase with thrombospondin motifs 5 that is encoded in the genome of human.


digestive system neoplasm

description: A neoplasm (disease) that involves the digestive system.


name: GA45A_HUMAN Growth arrest and DNA damage-inducible protein GADD45 alpha (sprot)

description: A growth arrest and DNA damage-inducible protein GADD45 alpha that is encoded in the genome of human.


name: S1PR2_HUMAN Sphingosine 1-phosphate receptor 2 (sprot)

description: A sphingosine 1-phosphate receptor 2 that is encoded in the genome of human.


darunavir

An N,N-disubstituted benzenesulfonamide bearing an unsubstituted amino group at the 4-position, used for the treatment of HIV infection. A second-generation HIV protease inhibitor, darunavir was designed to form robust interactions with the protease  enzyme from many strains of HIV, including those from treatment-experienced patients with multiple resistance mutations to other protease inhibitors.


Parageusia

description: A distortion of the sense of taste, often characterized by the sensation of a metallic taste.


name: CO1A2_HUMAN Collagen alpha-2(I) chain (sprot)

description: A collagen alpha-2(I) chain that is encoded in the genome of human.


name: ABCG5_HUMAN ATP-binding cassette sub-family G member 5 (sprot)

description: An ATP-binding cassette sub-family G member 5 that is encoded in the genome of human.


name: PGFRB_HUMAN Platelet-derived growth factor receptor beta (sprot)

description: A beta-type platelet-derived growth factor receptor that is encoded in the genome of human.


atrial tachycardia

description: A disorder characterized by an electrocardiographic finding of an organized, regular atrial rhythm with atrial rate between 101 and 240 beats per minute. The P wave morphology must be distinct from the sinus P wave morphology. (CDISC)


alcoholic liver diseases

description: A disorder caused by damage to the liver parenchyma due to alcohol consumption. It may present with an acute onset or follow a chronic course, leading to cirrhosis.


IL17D_HUMAN Interleukin-17D (sprot)

An interleukin-17D that is encoded in the genome of human.


portal vein thrombosis

description: The formation of a blood clot (thrombus) in the portal vein.


eosinophilic esophagitis

description: Eosinophilic esophagitis (EoE) is a chronic, allergic disease of the esophagus characterized clinically by symptoms of esophageal dysfunction (including vomiting, dysphagia, feeding disorders, food impaction and abdominal pain) which persist after treatment with proton pump inhibitors (PPIs).


hypophysitis

description: Inflammation of the pituitary gland.


CLD2_HUMAN Claudin-2 (sprot)

A claudin-2 that is encoded in the genome of human.


phosphatidylethanolamine (17:0/18:1)

A phosphatidylethanolamine 35:1 in which the acyl group at C-1 contains 17 carbons and no double bonds while that at C-2 contains 18 carbons and 1 double bond.


Supraventricular arrhythmia

description: A type of arrhythmia that originates above the ventricles, whereby the electrical impulse propagates down the normal His Purkinje system similar to normal sinus rhythm.


daidzein

A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4'.


APOE_HUMAN Apolipoprotein E (sprot)

An apolipoprotein E that is encoded in the genome of human.


name: CDPF1_HUMAN Cysteine-rich DPF motif domain-containing protein 1 (sprot)

description: A cysteine-rich DPF motif domain-containing protein 1 that is encoded in the genome of human.


name: GGNB2_HUMAN Gametogenetin-binding protein 2 (sprot)

description: A gametogenetin-binding protein 2 that is encoded in the genome of human.


pregabalin

A gamma-amino acid that is gamma-aminobutyric acid (GABA) carrying an isobutyl substitutent at the beta-position (the S-enantiomer). Binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues.


feline lymphoma

description: A lymphoma that occurs in cats. It is associated with exposure to feline leukemia virus and feline immunodeficiency virus.


Cerebral venous sinus thrombosis

description: An intracranial thrombosis of the venous sinuses. These typically present with headache, seizures or venous stroke secondary to raised cerebral venous pressure. Cerebral venous sinus thromboses usually affect larger areas of brain parenchyma than those affected by cerebral vein thromboses.


cobalamin

A cobalt-corrinoid hexaamide that is cobalamin with the oxidation state of the central cobalt atom unspecified.


open-angle glaucoma

description: Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage.


name: KLRG1_HUMAN Killer cell lectin-like receptor subfamily G member 1 (sprot)

description: A killer cell lectin-like receptor subfamily G member 1 that is encoded in the genome of human.


plasmablastic lymphoma

description: An aggressive diffuse large B-cell lymphoma frequently arising in the setting of HIV infection and characterized by the presence of large neoplastic cells resembling B-immunoblasts which have the immunophenotypic profile of plasma cells. Sites of involvement include the oral cavity, sinonasal cavity, skin, soft tissues, gastrointestinal tract, and bone.


name: PXDNL_HUMAN Probable oxidoreductase PXDNL (sprot)

description: A probable oxidoreductase PXDNL that is encoded in the genome of human.


name: TTP_HUMAN mRNA decay activator protein ZFP36 (sprot)

description: An mRNA decay activator protein ZFP36 that is encoded in the genome of human.


amantadine

A member of the class of  adamantanes that is used as an antiviral and  antiparkinson drug.


ovarian disorder

description: A disease involving the ovary.


name: DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 (sprot)

description: A serine/threonine-protein kinase DCLK1 that is encoded in the genome of human.


name: ELK1_HUMAN ETS domain-containing protein Elk-1 (sprot)

description: An ETS domain-containing protein Elk-1 that is encoded in the genome of human.


name: KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (sprot)

description: A calcium-activated potassium channel subunit alpha-1 that is encoded in the genome of human.


gastric ulcer

description: An ulcerated lesion in the mucosal surface of the stomach. It may progress to involve the deeper layers of the gastric wall.


FZD2_HUMAN Frizzled-2 (sprot)

A frizzled-2 that is encoded in the genome of human.


pirfenidone

A pyridone that is 2-pyridone substituted at positions 1 and 5 by phenyl and methyl groups respectively. An anti-inflammatory drug used for the treatment of idiopathic pulmonary fibrosis.


name: NCOA2_HUMAN Nuclear receptor coactivator 2 (sprot)

description: A nuclear receptor coactivator 2 that is encoded in the genome of human.


Acroosteolysis dominant type

description: A rare genetic osteolysis syndrome characterized by acroosteolysis of distal phalanges and generalized osteoporosis, associated with additional ossification anomalies, craniofacial dysmorphism, dental anomalies and a wide range of other characteristics.


An alpha-2-HS-glycoprotein that is encoded in the genome of human.


name: VDAC1_HUMAN Voltage-dependent anion-selective channel protein 1 (sprot)

description: A voltage-dependent anion-selective channel protein 1 that is encoded in the genome of human.


persistent fetal circulation syndrome

description: A cardiopulmonary disorder characterized by systemic arterial hypoxemia secondary to pulmonary hypertension and extrapulmonary right to left shunting across the foramen ovale and ductus arteriosus.


moxifloxacin

A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.


uveitis

description: An inflammatory process affecting a part of or the entire uvea. Causes include inflammatory agents (e.g., herpes simplex, herpes zoster, leptospirosis) and systemic diseases (e.g., inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, ankylosing spondylitis). Patients present with pain and redness in the eye, light sensitivity, and blurred and decreased vision.


name: IF2B1_HUMAN Insulin-like growth factor 2 mRNA-binding protein 1 (sprot)

description: An insulin-like growth factor 2 mRNA-binding protein 1 that is encoded in the genome of human.


name: HYAS1_HUMAN Hyaluronan synthase 1 (sprot)

description: A hyaluronan synthase 1 that is encoded in the genome of human.


name: HUWE1_HUMAN E3 ubiquitin-protein ligase HUWE1 (sprot)

description: An E3 ubiquitin-protein ligase HUWE1 that is encoded in the genome of human.


name: PAQR3_HUMAN Progestin and adipoQ receptor family member 3 (sprot)

description: A progestin and adipoQ receptor family member 3 that is encoded in the genome of human.


megestrol acetate

A steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer.


torsemide

An N-sulfonylurea obtained by formal condensation of [(3-methylphenyl)amino]pyridine-3-sulfonic acid with the free amino group of N-isopropylurea. It is a potent loop diuretic used for the treatment of hypertension and edema in patients with congestive heart failure.


skin squamous cell carcinoma

description: A carcinoma arising from the squamous cells of the epidermis. Skin squamous cell carcinoma is most commonly found on sun-exposed areas. The majority of the tumors are well-differentiated.


name: SO1C1_HUMAN Solute carrier organic anion transporter family member 1C1 (sprot)

description: A solute carrier organic anion transporter family member 1C1 that is encoded in the genome of human.


systemic lupus erythematosus

description: An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific.


name: ERP29_HUMAN Endoplasmic reticulum resident protein 29 (sprot)

description: An endoplasmic reticulum resident protein 29 that is encoded in the genome of human.


uric acid

An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.


fibrosarcoma

description: A malignant mesenchymal fibroblastic neoplasm affecting the soft tissue and bone.


name: AUTS2_HUMAN Autism susceptibility gene 2 protein (sprot)

description: An autism susceptibility gene 2 protein that is encoded in the genome of human.


plerixafor

An azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.


name: MLP3A_HUMAN Microtubule-associated proteins 1A/1B light chain 3A (sprot)

description: A microtubule-associated proteins 1A/1B light chain 3A that is encoded in the genome of human.


encephalopathy due to GLUT1 deficiency

description: Glucose transporter type 1 (GLUT1) deficiency syndrome is characterized by an encephalopathy marked by childhood epilepsy that is refractory to treatment, deceleration of cranial growth leading to microcephaly, psychomotor retardation, spasticity, ataxia, dysarthria and other paroxysmal neurological phenomena often occurring before meals. Symptoms appear between the age of 1 and 4 months, following a normal birth and gestation.


name: RMP_HUMAN Unconventional prefoldin RPB5 interactor 1 (sprot)

description: An unconventional prefoldin RPB5 interactor 1 that is encoded in the genome of human.


name: PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 (sprot)

description: A 3-phosphoinositide-dependent protein kinase 1 that is encoded in the genome of human.


name: PKN2_HUMAN Serine/threonine-protein kinase N2 (sprot)

description: A serine/threonine-protein kinase N2 that is encoded in the genome of human.


tibolone

Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormone receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.


CDSN_HUMAN Corneodesmosin (sprot)

A corneodesmosin that is encoded in the genome of human.


Moderate albuminuria

description: The presence of moderately increased concentrations of albumin in the urine, defined as and albumin-creatinine ratio (ACR) of 30 to 299 mg/gm (3.4 to 34 mg/mmol).


Hypermagnesemia

description: An abnormally increased magnesium concentration in the blood.


yellow nail syndrome

description: A very rare syndromic disorder characterized by the variable triad of characteristic yellow nails, chronic respiratory manifestations, and primary lymphedema.


name: MP2K2_HUMAN Dual specificity mitogen-activated protein kinase kinase 2 (sprot)

description: A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of human.


Visual field defect

description: An absolute or relative reduction in the extent of the normal field of vision.


name: UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase isozyme L1 that is encoded in the genome of human.


SNX16_HUMAN Sorting nexin-16 (sprot)

A sorting nexin-16 that is encoded in the genome of human.


SPB4_HUMAN Serpin B4 (sprot)

A serpin B4 that is encoded in the genome of human.


Erythroid hyperplasia

description: Increased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.


name: IRS2_HUMAN Insulin receptor substrate 2 (sprot)

description: An insulin receptor substrate 2 that is encoded in the genome of human.


gepirone

A member of the class of piperidones that is piperidine-2,6-dione substituted by a 4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl group at position 1 and two methyl groups at position 4.


meningoencephalitis

description: Inflammation of the meninges and brain, generally secondary to an infectious cause. Pathogens may be bacterial, viral, fungal, or protozoan.


TSH1_HUMAN Teashirt homolog 1 (sprot)

A teashirt homolog 1 that is encoded in the genome of human.


name: H6ST2_HUMAN Heparan-sulfate 6-O-sulfotransferase 2 (sprot)

description: A heparan-sulfate 6-O-sulfotransferase 2 that is encoded in the genome of human.


domoic acid

An L-proline derivative that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is produced by the diatomic algal Pseudo-nitzschia. It is an analogue of kainic acid and a neurotoxin which causes amnesic shellfish poisoning (ASP).


macular retinal edema

description: Accumulation of intraretinal fluid and protein in the macula, which may result in swelling and decreased central vision.


name: RYK_HUMAN Tyrosine-protein kinase RYK (sprot)

description: A tyrosine-protein kinase RYK that is encoded in the genome of human.


skin atrophy

description: The degeneration and thinning of the epidermis and dermis. It is usually a manifestation of aging.


acute myocardial infarction

description: Necrosis of the myocardium, as a result of interruption of the blood supply to the area. It is characterized by a severe and rapid onset of symptoms that may include chest pain, often radiating to the left arm and left side of the neck, dyspnea, sweating, and palpitations.


name: PINK1_HUMAN Serine/threonine-protein kinase PINK1, mitochondrial (sprot)

description: A serine/threonine-protein kinase PINK1, mitochondrial that is encoded in the genome of human.


ETHYL ACETATE

The acetate ester formed between acetic acid and ethanol.


AIRE_HUMAN Autoimmune regulator (sprot)

An autoimmune regulator that is encoded in the genome of human.


peripheral vascular disease

description: Any disorder affecting blood flow through the veins or arteries outside of the heart.


name: SOX11_HUMAN Transcription factor SOX-11 (sprot)

description: A transcription factor SOX-11 that is encoded in the genome of human.


vinorelbine

A vinca alkaloid with a norvinblastine skeleton.


hereditary myoglobinuria

description: The presence of myoglobin in the urine.


name: DYHC2_HUMAN Cytoplasmic dynein 2 heavy chain 1 (sprot)

description: A cytoplasmic dynein 2 heavy chain 1 that is encoded in the genome of human.


name: DC2I2_HUMAN Cytoplasmic dynein 2 intermediate chain 2 (sprot)

description: A cytoplasmic dynein 2 intermediate chain 2 that is encoded in the genome of human.


name: RIMB2_HUMAN RIMS-binding protein 2 (sprot)

description: A RIMS-binding protein 2 that is encoded in the genome of human.


clarithromycin

The 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis.


hemoglobinuria

description: A laboratory test result which indicates free hemoglobin in the urine.


geranylgeranyl diphosphate

A polyprenol diphosphate having geranylgeranyl as the polyprenyl component.


name: secondary progressive multiple sclerosis

description: A multiple sclerosis with a clinical course characterized by a progressive accumulation of neurological disability, independent of relapses, following an initial relapsing-remitting (RR) phase.


dengue disease

description: Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS).


name: E2F3_HUMAN Transcription factor E2F3 (sprot)

description: A transcription factor E2F3 that is encoded in the genome of human.


lupus erythematosus

description: An autoimmune, connective tissue chronic inflammatory disorder affecting the skin, joints, kidneys, lungs, heart, and the peripheral blood cells. It is more commonly seen in women than men. Variants include discoid and systemic lupus erythematosus.


name: HECD3_HUMAN E3 ubiquitin-protein ligase HECTD3 (sprot)

description: An E3 ubiquitin-protein ligase HECTD3 that is encoded in the genome of human.


name: 3BP1_HUMAN SH3 domain-binding protein 1 (sprot)

description: An SH3 domain-binding protein 1 that is encoded in the genome of human.


name: PAPOA_HUMAN Poly(A) polymerase alpha (sprot)

description: A poly(A) polymerase alpha that is encoded in the genome of human.