Myxoid liposarcoma metastatic

description: Myxoid liposarcoma that has spread to other anatomic sites.


Advanced Dedifferentiated Liposarcoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A dedifferentiated liposarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Pleomorphic Liposarcoma

description: Pleomorphic liposarcoma that has spread from its original site of growth to another anatomic site.


Advanced Pleomorphic Liposarcoma

description: Pleomorphic liposarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Locally Advanced Dedifferentiated Liposarcoma

description: Dedifferentiated liposarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Advanced Liposarcoma

description: A liposarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Recurrent Multinodular and Vacuolated Neuronal Tumor

description: The reemergence of multinodular and vacuolated neuronal tumor following a period of remission.


name: Adult Multinodular and Vacuolated Neuronal Tumor

description: A multinodular and vacuolated neuronal tumor that occurs in adults.


alkane

An acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, and therefore consisting entirely of hydrogen atoms and saturated carbon atoms.


long-chain alkane

Any alkane having a chain length of at least 13 carbon atoms.


Stage IV Ureter Cancer AJCC v8

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat. N0: No regional lymph node metastasis. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm in greatest dimension; or multiple lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


13-(beta-D-glucosyloxy)docosanoic acid

A beta-D-glucoside consisting of docosanoic (behenic) acid having a beta-D-glucosyloxy group at position 13.


DULOXETINE HYDROCHLORIDE

A duloxetine hydrochloride in which the duloxetine moiety has S configuration.


Cleft Maxilla

description: A congenital abnormality consisting of a fissure in the midline of the upper jawbone.


Fallopian Tube Lymphoma

description: An exceedingly rare lymphoma that arises from the fallopian tube.


N-tetracosanoylphytosphingosine

A phytoceramide compound having a tetracosanoyl group attached to the nitrogen atom.


clorprenaline

A racemate comprise of equimolar amounts of (R)- and (S)-clorprenaline. It is a beta2-adrenergic receptor agonist and a bronchodilator.


A glycosylxylose that is D-xylopyranose in which the hydroxy group at position 2 has been converted into the corresponding beta-D-glucopyranosyl derivative.


glycosylxylose

Any xylose in which one of the hydroxy groups has undergone formal glycosylation.


A glycosylxylose consisting of beta-D-glucopyranose and beta-D-xylofuranose residues joined in sequence by a (1->5) glycosidic bond.


A glycosylxylose that is beta-D-xylopyranose in which the hydroxy group at position 3 has been converted into the corresponding beta-D-glucopyranoside.


xylobiose

A glycosylxylose that is D-xylopyranose having a beta-D-xylopyranosyl residue attached at position 4 via a glycosidic bond.


A glycosylxylose consisting of alpha-D-glucopyranose and D-xylopyranose residues joined in sequence by a (1->4) glycosidic bond.


A disaccharide consisting of a beta-D-galactopyranose residue joined to a D-xylopyranose residue by a (1->4) glycosidic bond. Used to diagnose hypolactasia (lactose intolerance as a result of lactase deficiency) via presence of D-xylose after cleavage by lactase.


A glycosylxylose consisting of beta-D-glucopyranose and beta-D-xylopyranose residues joined in sequence by a (1->4) glycosidic bond.


A disaccharide consisting of beta-D-glucopyranose and D-xylopyranose residues joined in sequence by a (1->4) glycosidic bond.


A disaccharide that is D-xylopyranose in which the hydroxy group at position 3 has been converted into the corresponding beta-D-galactopyranoside.


A glycosylxylose that is beta-D-xylopyranose in which the hydroxy group at position 2 has been converted to the corresponding 2-O-beta-D-glucopyranoside.


A glycosylxylose that is beta-D-xylopyranose in which the hydroxy group at position 4 has been converted into the corresponding beta-D-galactopyranoside.


A glycosylxylose consisting of beta-D-glucopyranuronic acid and D-xylopyranose residues joined in sequence by a (1->4) glycosidic bond.


A glycosylxylose consisting of a beta-D-glucopyranose residue and a D-xylopyranose residue joined in sequence by a (1->5) glycosidic bond.


A glycosylxylose consisting of a beta-D-galactopyranose residue and a beta-D-xylopyranose residue joined in sequence by a (1->3) glycosidic bond.


A disaccharide that is beta-D-xylose in which the hydroxy group at position 4 has been converted into the corresponding alpha-D-glucopyranoside.


A glycosylxylose consisting of beta-D-glucopyranuronic acid and beta-D-xylopyranose joined in sequence by a (1->4) glycosidic bond.


A glycophytoceramide having a 4-O-{3-[4-(trifluoromethyl)phenyl]propyl}-alpha-D-galactosyl residue at the O-1 position and a hexacosanoyl group attached to the nitrogen. One of a series of an extensive set of 4"-O-alkylated alpha-GalCer analogues evaluated (PMID:30556652) as invariant natural killer T-cell (iNKT) antigens.


A glycosylceramide in which the glycosyl moiety is alpha-D-galactose and the ceramide is N-(hexacosanoyl)-11,12-methylene-C22-sphinganine.


A secondary alcohol that is butan-2-ol in which one of the methyl hydrogen atoms is substituted by chlorine.


Bacteriological Finding

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Objective evidence of bacterial infection perceptible to the examiner by laboratory procedure.


NEOMETHYMYCIN

A twelve-membered macrolide antibiotic that is biosynthesised by Streptomyces venezuelae.


An unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of trans-dec-3-enoic acid.


A quercetin O-glucoside that is quercetin attached to a beta-D-sophorosyl residue at position 3 via a glycosidic linkage.


Gastric melanoma

description: A melanoma that arises from mucosa of the stomach.


A 3-oxo-5alpha-steroid formed from 11-deoxycorticosterone by reduction across the C4-C5 double bond.


ROPIVACAINE HYDROCHLORIDE

The anhydrous form of (S)-ropivacaine hydrochloride.


(E)-dimethomorph

An enamide resulting from the formal condensation of (2E)-3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acrylic acid with the amino group of morpholine. The agricultural fungicide dimethomorph is a mixture of (E)- and (Z)-dimethomorph; only the Z isomer has fungicidal activity.


straight-chain fatty acid

Any fatty acid whose skeletal carbon atoms form an unbranched open chain.


but-3-enoic acid

That isomer of butenoic acid having the double bond at position C-3.


(9Z,12E)-hexadecadienoic acid

A hexadecadienoic acid having two double bonds located at positions 9 and 12 (the 9Z,12E-geoisomer).


all-cis-icosa-5,8,14-trienoic acid

An icosatrienoic acid with three cis-double bonds at positions 5, 8 and 14.


pent-3-enoic acid

A pentenoic acid having the double bond at position 3.


hydroxypalmitic acid

A hydroxy fatty acid that is palmitic (hexadecanoic) acid substituted with one hydroxy group.


A HETrE that is (8Z,10E,14Z)-icosatrienoic acid in which the hydroxy group is located at the 12(S)-posiiton.


A hydroxyeicosatrienoic acid that consists of 6E,8Z,11Z-eicosatrienoic acid bearing a 5-hydroxy substituent.


7,10,13,16-docosatetraenoic acid

A docosatetraenoic acid in which the four double bonds are located at positions 7, 10, 13 and 16 (geometry unspecified).


trans-dec-3-enoic acid

A decenoic acid having a trans- double bond at position 3.


hexacosahexaenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any six positions of a 26-carbon straight chain.


parinaric acid

An octadecatetraenoic acid containing a conjugated system of  double bonds at positions 9, 11, 13 and 15.


linolenic acid

A two-membered subclass of octadecatrienoic acid comprising the (9Z,12Z,15Z)- and (6Z,9Z,12Z)-isomers. Linolenic acids are nutrients essential to the formation of prostaglandins and are also used in making paints and synthetic resins.


6-hydroxyhexanoic acid

An omega-hydroxy fatty acid comprising hexanoic acid having a hydroxy group at the 6-position.


octadecadiynoic acid

Any C18 straight-chain fatty acid having two C#C triple bonds.


5-hydroxypentanoic acid

An omega-hydroxy fatty acid consisting of pentanoic acid carrying a hydroxy group at C-5.


(15R)-15-hydroxypalmitic acid

An (omega-1)-hydroxy fatty acid that is hexadecanoic acid in which the 15-pro-R hydrogen is replaced by a hydroxy group.


dotriacontapentaenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any five positions of a 32-carbon straight chain.


trioxilin

Any icosatrienoic acid having three hydroxy substituents.


(5Z,11Z,14Z)-icosatrienoic acid

An icosatrienoic acid in which the three double bonds have Z configuration and are located at positions 5, 11 and 14.


triacontahexaenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any six positions of a 30-carbon straight chain.


octadecynoic acid

Any C18, straight-chain, monounsaturated fatty acid having a C#C triple-bond at any position.


(E,Z,E)-octadeca-9,11,13-trienoic acid

A  9,11,13-octadecatrienoic acid having its double bonds in trans, cis and trans configurations, respectively.


A very long-chain omega-3 fatty acid that is octatriacontanoic acid having six double bonds located at positions 23, 26, 29, 32 and 35 (the 23Z,26Z,29Z,32Z,35Z-isomer).


11-tetradecenoic acid

A tetradecenoic acid having its double bond in the 11-position.


A very long-chain omega-3 fatty acid that is octacosanoic acid having six double bonds located at positions 10, 13, 16, 19, 22 and 25 (the 10Z,13Z,16Z,19Z,22Z,25Z-isomer).


9-pentadecenoic acid

A pentadecenoic acid having its double bond in the 9-position.


12-oxo-trans-10-dodecenoic acid

A monounsaturated fatty acid comprising dodecanoic acid having a trans-double bond at the 10-position and a 12-oxo group.


A very long-chain polyunsaturated fatty acid that is tetracosanoic acid having six double bonds located at positions 6, 9, 12, 15, 18 and 21 (the (6Z,9Z,12Z,15Z,18Z,21Z-isomer).


alpha-licanic acid

A trienoic fatty acid comprising alpha-eleostearic acid having a 4-oxo substituent.


dec-9-enoic acid

A decenoic acid having the double bond at position 9.


(9E,11E)-octadecadienoic acid

An octadeca-9,11-dienoic acid having 9-trans,11-trans-stereochemistry.


6-oxohexanoic acid

A medium-chain fatty acid comprising hexanoic acid carrying an oxo group at position 6.


colneleic acid

A long-chain, divinyl ether fatty acid composed of 8-nonenoic acid having the E- hydrogen at position 9 substituted by a (1E,3Z)-nona-1,3,-dien-1-yloxy group.


conjugated linolenic acid

Any n-3 (alpha) or n-6 (gamma)  octadecatrienoic acid in which at least two of the three double bonds are conjugated.


(S)-laballenic acid

The (S)-enantiomer of laballenic acid.


(R)-laballenic acid

The (R)-enantiomer of laballenic acid.


A TriHOME that is (11E)-octadec-11-enoic acid in which the three hydroxy substituents are located at positions 9, 10 and 13.


octadecadienoic acid

Any straight-chain, C18 polyunsaturated fatty acid having two C=C double bonds.


cis-tetradec-7-enoic acid

A tetradecenoic acid having a cis-double bond at the 7-position.


10-pentadecenoic acid

A pentadecenoic acid having its double bond in the 10-position.


(2E)-9-hydroxynon-2-enoic acid

A monounsaturated fatty acid that is (2E)-non-2-enoic acid in which one of the hydrogens at position 9 is replaced by a hydroxy group.


A polyunsaturated fatty acid that is octadecapentaenoic acid in which the five double bonds are located at positions 2, 4, 6, 8 and 10 (the all-trans-geoisomer).


conjugated linoleic acid

An octadecadienoic acid having a system of two conjugated double bonds at any position.


18-hydroxyoleic acid

An omega-hydroxy fatty acid that is 18-hydroxyoctadecanoic acid which has been dehydrogenated to introduce a trans double bond at the 9-10 position.


docosapentaenoic acid

Any straight-chain, C22 fatty acid having five C=C double bonds.


A very long-chain omega-6 fatty acid that is tetracosanoic acid having four double bonds located at positions 9, 12, 15 and 18 (the 9Z,12Z,15Z,18Z-isomer).


2-tetradecenoic acid

A tetradecenoic acid having its double bond in the 2-position.


tetracosapentaenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any five positions of a 24-carbon straight chain.


(Z)-hexadec-11-enoic acid

A C16, monounsaturated fatty acid with a double bond at position 11; a key intermediate in silkworm pheromone biosynthesis.


A hydroxyeicosatrienoic acid that consists of 9E,11Z,14Z-eicosatrienoic acid bearing an 8-hydroxy substituent.


10-nonadecenoic acid

A monounsaturated fatty acid that is nonadecanoic acid with a double bond at position 10.


A very long-chain omega-6 fatty acid that is dotriacontapentaenoic acid having five double bonds located at positions 14, 17, 20, 23 and 26 (the 14Z,17Z,20Z,23Z,26Z-isomer).


9-cis,11-trans-octadecadienoic acid

An octadeca-9,11-dienoic acid having 9-cis,11-trans-stereochemistry.


trans-undec-2-enoic acid

A 2-undecenoic acid in which the olefinic double bond has E configuration.


(2E)-4-hydroxynon-2-enoic acid

A 4-hydroxynon-2-enoic acid in which the double bond has (E)-configuration.


14-hydroxypalmitic acid

A hydroxy fatty acid that is palmitic (hexadecanoic) acid carrying a single hydroxy substituent at position 14.


A very long-chain omega-6 fatty acid that is octacosanoic acid having four double bonds located at positions 13, 16, 19, 22 (the 13Z,16Z,19Z,22Z-isomer).


omega-hydroxytetracosanoic acid

An omega-hydroxy fatty acid that is the 24-hydroxy derivative of tetracosanoic acid.


octacosapentaenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any five positions of a 28-carbon straight chain.


(S)-2-hydroxyhexadecanoic acid

The S-enantiomer of 2-hydroxypalmitic acid.


omega-hydroxydotriacontanoic acid

An omega-hydroxy fatty acid that is the 32-hydroxy derivative of dotriacontanoic acid.


(2E)-20-hydroxyicos-2-enoic acid

An omega-hydroxy fatty acid that is trans-2-icosenoic acid in which one of the hydrogens of the terminal methyl group has been replaced by a hydroxy group.


all-cis-icosa-11,14,17-trienoic acid

An icosatrienoic acid having three cis- double bonds at positions 11, 14 and 17.


hexatriacontahexaenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any six positions of a 36-carbon straight chain.


A 9,11,15-octadecatrienoic acid in which the configuration of the double bonds at positions 9 and 15 is Z, while that of the double bond at position 11 is E.


11,13,15-octadecatrienoic acid

Any octadecatrienoic acid with three fully-conjugated double bonds at positions 11, 13 and 15.


(8Z,11Z,14Z)-heptadecatrienoic acid

A trienoic fatty acid that is heptadecenoic acid having three double bonds located at postions 8, 11 and 14 (the 8Z,11Z,14Z-geoisomer).


octadecatrienoic acid

Any trienoic fatty acid having eighteen carbons.


(R)-2-hydroxyhexadecanoic acid

The R-enantiomer of 2-hydroxypalmitic acid.


(2E)-18-hydroxyoctadec-2-enoic acid

An omega-hydroxy fatty acid that is trans-octadec-2-enoic acid in which one of the hydrogens of the terminal methyl group has been replaced by a hydroxy group.


cis-pent-2-enoic acid

A pent-3-enoic acid in cis- configuration.


A very long-chain omega-3 fatty acid that is triacontapentaenoic acid having five double bonds located at positions 15, 18, 21, 24 and 27 (the 15Z,18Z,21Z,24Z,27Z-isomer).


16-hydroxyhexadecanoic acid

An omega-hydroxy-long-chain fatty acid that is hexadecanoic acid (also known as palmitic acid) which is substituted at position 16 by a hydroxy group. It is a key monomer of cutin in the plant cuticle.


2-oxohexadecanoic acid

An oxo fatty acid that is the 2-oxo derivative of hexadecanoic (palmitic) acid.


fatty acid 20:3

Any trienoic fatty acid with twenty carbons.


4-hydroxylauric acid

A hydroxy fatty acid comprising lauric acid carrying a hydroxy group at C-4.


hexadecadienoic acid

Any straight-chain, C16 polyunsaturated fatty acid containing two C=C double bonds (position and geometry not specified).


6-OCTADECYNOIC ACID

An octadecynoic acid having its triple bond at position 6.


trans-11-tetradecenoic acid

The trans-isomer of tetradec-11-enoic acid.


hexatriacontatetraenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any four positions of a 36-carbon straight chain.


An octadecenediynoic acid that is stearic acid with a cis double bond at position 13, two triple bonds at positions 9 and 11, and a hydroxy group at C-8.


hexadecatrienoic acid

Any trienoic fatty acid having sixteen carbons.


trioxilin A3

A trioxilin having (5Z,9E,14Z) double bond configuration; and 8-, (11R)- and (12S)-hydroxy substituents.


lynenic acid

A docosatetraenoic acid carrying four cis-double bonds at positions 10, 13, 16 and 19.


trans-10-pentadecenoic acid

The trans-isomer of pentadec-10-enoic acid.


(2E)-oct-2-enoic acid

An olefinic fatty acid that is octanoic acid carrying a double bond at position 2 (the 2E-isomer).


A very long-chain omega-3 fatty acid that is tetracosanoic acid having five double bonds located at positions 9, 12, 15, 18 and 21 (the (9Z,12Z,15Z,18Z,21Z-isomer).


(5Z,9Z,12Z,15Z)-octadecatetraenoic acid

An octadecatetraenoic acid having four double bonds located at positions 5, 9, 12 and 15 (the all-cis-isomer).


(2E)-11-hydroxyundec-2-enoic acid

An omega-hydroxy fatty acid that is trans-undec-2-enoic acid in which one of the hydrogens attached to the terminal methyl group is replaced by a hydroxy group.


tricosenoic acid

Any C23 monounsaturated fatty acid containing one double bond at an unspecified position.


7-hydroxyheptanoic acid

An omega-hydroxy fatty acid comprising heptanoic acid which is substituted by a hydroxy group at position 7.


A very long-chain omega-3 fatty acid that is dotriacontapentaenoic acid having six double bonds located at positions 14, 17, 20, 23, 26 and 29 (the 14Z,17Z,20Z,23Z,26Z,29Z-isomer).


A HETrE that is (5Z,8Z,11Z)-icosatrienoic acid substituted at position 19 by a hydroxy group.


(10Z)-nonadec-10-enoic acid

The (Z)-stereoisomer of  10-nonadecenoic acid.


(2E)-17-hydroxyheptadec-2-enoic acid

An omega-hydroxy fatty acid that is (2E)-2-heptadecenoic acid in which one of the hydrogens of the terminal methyl group has been replaced by a hydroxy group.


dotriacontahexaenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any six positions of a 32-carbon straight chain.


(E)-10-hydroxydec-2-enoic acid

An omega-hydroxy amino acid that is 2-decenoic acid in which one of the hydrogens attached to the terminal carbon is replaced by a hydroxy group and in which the C=C double bond has E configuration. It is a component of royal jelly.


9,11,14-octadecatrienoic acid

Any octadecatrienoic acid with three double bonds at positions 9, 11 and 14


(2E)-12-hydroxydodec-2-enoic acid

An omega-hydroxy fatty acid that is trans-2-dodecenoic acid in which one of the hydrogens attached to the terminal methyl group is replaced by a hydroxy group.


A very long-chain omega-6 fatty acid that is octacosanoic acid having five double bonds located at positions 10, 13, 16, 19 and 22 (the 10Z,13Z,16Z,19Z,22Z-isomer).


3-hydroxypalmitic acid

A long-chain fatty acid that is the 3-hydroxy derivative of palmitic acid.


A hydroxy polyunsaturated fatty acid that is (2E,4E,8Z)-tetradeca-2,4,8-trienoic acid which is carrying a hydroxy group at the 6R-position.


pentadecenoic acid

Any C15 straight-chain monounsaturated fatty acid having one C=C double bond.


A HETrE that is (5Z,8Z,11Z)-icosatrienoic acid substituted at position 20 by a hydroxy group.


A very long-chain omega-6 fatty acid that is hexatriacontanoic acid having five double bonds located at positions 18, 21, 24, 27 and 30 (the 18Z,21Z,24Z,27Z,30Z-isomer).


A very long-chain omega-6 fatty acid that is tetracosanoic acid having five double bonds located at positions 6, 9, 12, 15 and 18 (the 6Z,9Z,12Z,15Z,18Z-isomer).


octacosatetraenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any four positions of a 28-carbon straight chain.


A straight-chain polyunsaturated fatty acid composed of eighteen carbons and containing two double bonds, both with Z-geochemistry, at positions 9 and 12 as well as a triple bond at position 6.


colnelenic acid

A long-chain, divinyl ether fatty acid composed of 8-nonenoic acid in which the E-hydrogen at position 9 is substituted by a (1E,3Z,6Z)-nona-1,3,6-trien-1-yloxy group.


(2E,4Z)-8-hydroxydeca-2,4-dienoic acid

A polyunsaturated fatty acid that is deca-2,4-dienoic acid substituted by a hydroxy group at position 8 (the 2E,4Z stereoisomer).


dihomolinoleic acid

A octadecadienoic acid with unsaturation at positions 10 and 12 (the 10Z,12Z-stereoisomer).


A polyunsaturated fatty acid that is tetracosanoic acid having seven double bonds at positions 2, 6, 9, 12, 15, 18 and 21 (the 2E,6Z,9Z,12Z,15Z,18Z,21Z-isomer).


(9Z,11E,13Z)-octadecatrienoic acid

A 9,11,13-octadecatrienoic acid having its double bonds in cis, trans and cis configurations, respectively. It has been isolated from  pomegranate (Punica granatum).


A very long-chain omega-6 fatty acid that is hexacosanoic acid containing five double bonds located at positions 8, 11, 14, 17 and 20 (the 8Z,11Z,14Z,17Z,20Z-isomer).


A very long-chain omega-3 fatty acid that is hexatriacontanoic acid having six double bonds located at positions 18, 21, 24, 27, 30 and 33 (the 18Z,21Z,24Z,27Z,30Z,33Z-isomer).


cis-9-nonadecenoic acid

A monounsaturated fatty acid that is nonadecanoic acid that has been dehydrogenated to introduce a double bond with Z configuration between the carbons at positions 9 and 10. It has been isolated from the spores of reishi mushroom, Ganoderma lucidum, and found to inhibit tumour cell proliferation and induce apoptosis of HL-60 cells.


A conjugated linolenic acid having three fully-conjugated double bonds at positions 9, 11 and 13, in cis, trans and trans configurations, respectively.


(9Z)-pentadecenoic acid

A 9-pentadecenoic acid in which the double bond adopts cis-configuration.


(2E)-19-hydroxynonadec-2-enoic acid

An omega-hydroxy fatty acid that is 19-hydroxynonadecanoic acid which has been dehydrogenated to introduce a trans double bond at the 2-3 position.


octadeca-9,12-diynoic acid

An octadecadiynoic acid having its triple bonds at positions 9 and 12.


octatriacontatetraenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any four positions of a 38-carbon straight chain.


butenoic acid

Any C4, straight-chain fatty acid containing one double bond.


(5Z,7E,9E,14Z,17Z)-icosapentaenoic acid

The (5Z,7E,9E,14Z,17Z)-isomer of icosapentaenoic acid.


(9E)-tetradecenoic acid

A tetradecenoic acid that is the E-geoisomer of tetradec-9-enoic acid.


cis-tetradec-5-enoic acid

A straight-chain, monounsaturated, 14-carbon long-chain fatty acid with a cis-double bond at position C-5


A very long-chain omega-3 fatty acid that is triacontahexaenoic acid having six double bonds located at positions 12, 15, 18, 21, 24 and 27 (the 12Z,15Z,18Z,21Z,24Z,27Z-isomer).


(17Z)-hexacosenoic acid

A very long-chain monounsaturated fatty acid that is hexacosanoic acid having a double bond at position 17 (the Z-isomer).


octadeca-10,12-diynoic acid

An octadecadiynoic acid having its triple bonds at positions 10 and 12.


hexacosatetraenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any four positions of a 26-carbon straight chain.


all-cis-7,10,13-hexadecatrienoic acid

A hexadecatrienoic acid having Z double bonds at positions 7, 10 and 13.


(R)-4-hydroxylauric acid

An optically active form of 4-hydroxylauric acid having (R)-configuration.


dodecadienoic acid

A C12, polyunsaturated acid carrying two double bonds at any position.


(5Z)-5-octenoic acid

An olefinic fatty acid that is octanoic acid carrying a double bond at position 5 (the 5Z-isomer).


(7Z,10Z)-hexadecadienoic acid

A hexadecadienoic acid having two double bonds located at positions 7 and 10 (the 7Z,10Z-geoisomer).


(9Z)-heptadecenoic acid

A heptadecenoic acid in which the double bond is located at the 9-10 position and has Z configuration.


mycomycin

A straight-chain polyunsaturated fatty acid comprising tridecanoic acid having (E)- and (Z)-double bonds at positions 3 and 5 respectively, an allenic system at positions 7-9 and triple bonds at positions 10 and 12.


A very long-chain omega-3 fatty acid that is tetratriacontapentaenoic acid having five double bonds located at positions 19, 22, 25 ,28 and 31 (the 19Z,22Z,25Z,28Z,31Z-isomer).


7-tetradecenoic acid

A tetradecenoic acid having its double bond in the 7-position.


(5Z,8Z,11Z)-icosatrienoic acid

A 5,8,11-eicosatrienoic acid in which all three double bonds adopt cis-configuration.


dotriacontatetraenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any four positions of a 32-carbon straight chain.


A very long-chain omega-3 fatty acid that is hexatriacontanoic acid having five double bonds located at positions 21, 24, 27, 30 and 33 (the 21Z,24Z,27Z,30Z,33Z-isomer).


10-hydroxypalmitic acid

A hydroxypalmitic acid that is palmitic (hexadecanoic) acid carrying a single hydroxy substituent at position 10.


trans-2-hexacosenoic acid

The trans-isomer of 2-hexacosenoic acid


22-tricosenoic acid

A tricosenoic acid having a double bond at position 22.


(2E)-7-hydroxyhept-2-enoic acid

An omega-hydroxy fatty acid that is trans-2-heptenoic acid in which one of the hydrogens of the terminal methyl group is replaced by a hydroxy group.


hexadec-9-enoic acid

A hexadecenoic acid in which the double bond is located at position 9.


A very long-chain omega-3 fatty acid that is octacosanoic acid having five double bonds located at positions 13, 16, 19, 22 and 25 (the 13Z,16Z,19Z,22Z,25Z-isomer).


A polyunsaturated fatty acid that is hexadeca-2,4,8,10-tetraenoic acid substituted by a hydroxy group at position 7. All 4 double bonds have E- (trans-) geometry.


jalapinolic acid

A hydroxypalmitic acid that is palmitic acid substituted by hydroxy group at position 11 (the 11S stereoisomer).


A hydroxyeicosatrienoic acid that consists of 8Z,11Z,13E-icosatrienoic acid bearing an additional 15-hydroxy substituent.


A  polyunsaturated fatty acid that is icosanoic acid having unsaturation at positions 2, 5, 8, 11, 14 and 17. It has been found in  Daphnia galeata.


(9E)-pentadecenoic acid

A 9-pentadecenoic acid in which the double bond adopts trans-configuration.


tetratriacontapentaenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any five positions of a 34-carbon straight chain.


octadecenynoic acid

Any C18 polyunsaturated fatty acid containing one C=C and one C#C bond.


9,11,15-octadecatrienoic acid

Any octadecatrienoic acid with three double bonds at positions 9, 11 and 15.


(3E,5Z)-tetradecadienoic acid

A long-chain polyunsaturated fatty acid that is tetradecanoic acid containing two double bonds at positions 3 and 5 (the 3E,5Z-geoisomer).


octacosahexaenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any six positions of a 28-carbon straight chain.


HETrE

A long-chain polyunsaturated fatty acid that is any icosatrienoic acid bearing a single hydroxy substituent. An oxidation product of icosatrienoic acid metabolism.


cetoleic acid

A docosenoic acid having a cis-double bond at position 11.


(4Z)-hexadecenoic acid

A hexadecenoic acid with a cis-double bond at position C-4.


2-hexacosenoic acid

A hexacosenoic acid with the double bond at the 2-position.


2-undecenoic acid

An undecenoic acid having its double bond in the 2-position.


cis-4-decenoic acid

A decenoic acid having a cis- double bond at position 4.


A very long-chain omega-3 fatty acid that is dotriacontapentaenoic acid having five double bonds located at positions 17, 20, 23, 26 and 29 (the 17Z,20Z,23Z,26Z,29Z-isomer).


laballenic acid

A C18, 5,6-allenic fatty acid.


A polyunsaturated fatty acid that is deca-2,8-dien-4-ynoic acid substituted at position 10 by a hydroxy group (the 2E,8E-geoisomer)


(Z)-hexadec-7-enoic acid

A C16 fatty acid having a (Z)-double bond at the 7-position; marker of early life stage mortality in trout and of physiologically active autotrophic bacteria in complex microbial communities.


(2E)-14-hydroxytetradec-2-enoic acid

An omega-hydroxy fatty acid that is trans-2-tetradecenoic acid in which one of the hydrogens of the terminal methyl group has been replaced by a hydroxy group.


stearolic acid

An octadecynoic acid having its triple bond at position 9.


DICRANIN

A trienoic fatty acid, that is octadecanoic acid containing double bonds at positions 9, 12 and 15 and a triple bond at position 6. Isolated from Dicranum scoparium, it exhibits antibacterial activity and inhibitory activity against arachidonate 15-lipoxygenase.


(9Z)-hexacosenoic acid

A hexacosenoic acid in which the double bond is located at position 9 and has Z configuration.


tetratriacontatetraenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any four positions of a 34-carbon straight chain.


9,11,13-octadecatrienoic acid

Any octadecatrienoic acid with three fully-conjugated double bonds at positions 9, 11 and 13.


triacontapentaenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any five positions of a 30-carbon straight chain.


A very long-chain omega-6 fatty acid that is tetratriacontapentaenoic acid having five double bonds located at positions 16, 19, 22, 25 and 28 (the 16Z,19Z,22Z,25Z,28Z-isomer).


cis-9-undecenoic acid

The cis-isomer of 9-undecenoic acid.


(5Z,9Z,12Z)-octadecatrienoic acid

An octadecatrienoic acid having three double bonds located at positions 5, 9 and 12 (the all-cis-isomer).


pentenoic acid

Any C5, straight-chain, monounsaturated fatty acid.


ambrettolic acid

An omega-hydroxy-long-chain fatty acid that is hexadec-7-enoic acid carrying a hydroxy group at position 16.


triacontatetraenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any four positions of a 30-carbon straight chain.


4-hydroxynon-2-enoic acid

A medium-chain fatty acid that is non-2-enoic acid substituted at position 4 by a hydroxy group.


(2E)-16-hydroxyhexadec-2-enoic acid

An omega-hydroxy fatty acid that is trans-2-hexadecenoic acid in which one of the hydrogens of the terminal methyl group has been replaced by a hydroxy group.


An octadecatetraenoic acid having four double bonds located at positions 6, 9, 12 and 15 (the all-cis-isomer). It has been isolated from Lithospermum officinale and fish oils.


tetracosenoic acid

Any C24 monounsaturated fatty acid containing one double bond.


trans-2-tetradecenoic acid

A 2-tetradecenoic acid having trans-configuration.


tetracosahexaenoic acid

Any C24 straight-chain fatty acid containing six C=C double bonds.


(14Z)-hexadecenoic acid

A hexadecenoic acid in which the double bond is located at position 14 and has cis-configuration.


The (9Z,11E,13E,15Z)-isomer of parinaric acid.


octadeca-10,12-dienoic acid

A conjugated linoleic acid having double bonds at positions 10 and 12.


An omega-3 fatty acid that is tetratriacontahexaenoic acid having six double bonds located at positions 16, 19, 22, 25 ,28 and 31 (the 16Z,19Z,22Z,25Z,28Z,31Z-isomer).


trioxilin B3

A trioxilin having (all-cis 5,8,14) double bond configuration; and 10-, (11S)- and (12R)-hydroxy substituents.


docosenoic acid

A C22, monounsaturated fatty acid carrying a C=C double bond at any position.


tetradecenoic acid

Any C14 straight-chain monounsaturated fatty acid having one C=C double bond.


cis-8-heptadecenoic acid

A heptadecenoic acid in which the double bond is located at the 8-9 position and has Z configuration.


RICINOLEIC ACID

A straight-chain, 18:1, long-chain fatty acid having a trans- double bond at position 9 and an R-oriented hydroxy group at position 12.


tetracosatetraenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any four positions of a 24-carbon straight chain.


(8E,10E,12Z)-octadecatrienoic acid

A conjugated linolenic acid having three double bonds located at positions 8, 10 and 12 (the 8E,10E,12Z-geoisomer)


omega-hydroxytriacontanoic acid

An omega-hydroxy fatty acid that is the 30-hydroxy derivative of triacontanoic acid.


15-hydroxypalmitic acid

A hydroxy fatty acid that is palmitic (hexadecanoic) acid carrying a single hydroxy substituent at position 15.


The all-trans isomer of 9,11,13-octadecatrienoic acid.


octatriacontapentaenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any five positions of a 38-carbon straight chain.


(S)-4-hydroxylauric acid

An optically active form of 4-hydroxylauric acid having (S)-configuration.


cis-11-tetradecenoic acid

The cis-isomer of tetradec-11-enoic acid.


(2E)-21-hydroxyhenicos-2-enoic acid

An omega-hydroxy fatty acid that is 21-hydroxyhenicosanoic acid that has been dehydrogenated to introduce a trans double bond at the 2-3 position.


A very long-chain omega-3 fatty acid that is hexacosanoic acid having six double bonds located at positions 8, 11, 14, 17, 20, 23 (the 8Z,11Z,14Z,17Z,20Z,23Z-isomer).


scleropyric acid

A straight-chain fatty acid that is heptadecanoic acid with a terminal double bond and a triple bond at position 12. Isolated from the twigs of Scleropyrum wallichianum, it exhibits antimycobacterial and antiplasmodial activities.


isocrotonic acid

A but-2-enoic acid having a cis- double bond at C-2.


hexadecenoic acid

A C16 straight-chain monounsaturated fatty acid having one C=C double bond.


hexacosenoic acid

A  monounsaturated fatty acid whose structure contains one double bond at any position of a 26-carbon straight chain.


(3E,5Z)-dodecadienoic acid

A medium-chain polyunsaturated fatty acid that is dodecanoic acid containing two double bonds at positions 3 and 5 (the 3E,5Z-geoisomer).


9-undecenoic acid

An undecenoic acid having its double bond in the 9-position.


(5Z,9Z)-5,9-hexacosadienoic acid

A polyunsaturated fatty acid that is hexacosanoic acid carrying double bonds at positions 5 and 9 respectively (the 5Z,9Z-isomer).


A very long-chain omega-6 fatty acid that is tetracosanoic acid having four double bonds located at positions 17, 20, 23 and 26 (the 17Z,20Z,23Z,26Z-isomer).


octadecatetraenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any four positions of an 18-carbon straight chain.


(2E)-13-hydroxytridec-2-enoic acid

An omega-hydroxy fatty acid that is tridecanoic acid that has been dehydrogenated to introduce a trans double bond at the 2-3 position and in which one of the hydrogens attached to the terminal methyl group is replaced by a hydroxy group.


9-hydroxynonanoic acid

An omega-hydroxy fatty acid that is nonanoic acid in which one of the hydrogens of the terminal methyl group is replaced by a hydroxy group.


hexatriacontapentaenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any five positions of a 36-carbon straight chain.


8-undecenoic acid

An undecenoic acid having its double bond in the 8-position.


DOCOSAPENTAENOIC ACID

The all-cis-isomer of a C22 polyunsaturated fatty acid having five double bonds in the 7-, 10-, 13-, 16- and 19-positions.


decenoic acid

Any C10 monounsaturated fatty acid having a double bond in the carbon backbone.


MINQUARTYNOIC ACID

A straight-chain, C18 polyunsaturated fatty acid having four conjugated C#C bonds at positions 9, 11, 13 and 15 as well as an (S)-hydroxy group at position 17.


A very long-chain omega-6 fatty acid that is triacontanoic acid having five double bonds located at positions 12, 15, 18, 21 and 24 (the 12Z,15Z,18Z,21Z,24Z-isomer).


(5Z,9E,14Z)-icosa-5,9,14-trienoic acid

An icosatrienoic acid having a (5Z,9E,14Z) double bond configuration.


tetratriacontahexaenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any six positions of a 34-carbon straight chain.


cis-2-hexacosenoic acid

The cis-isomer of 2-hexacosenoic acid


trans-9-undecenoic acid

The trans-isomer of 9-undecenoic acid.


(3E)-3-hexadecenoic acid

A hexadecenoic acid having a trans-double bond at the 3-position.


(9Z)-octadec-9-en-12-ynoic acid

An octadecenynoic acid having a cis-double bond at C-9 and a triple bond at position 12.


A very long-chain omega-6 fatty acid that is tetracosanoic acid having four double bonds located at positions 11, 14, 17 and 20 (the 11Z,14Z,17Z,20Z-isomer).


11-octadecynoic acid

An octadecynoic acid having its triple bond at position 11.


(E)-hexadec-2-enoic acid

A hexadecenoic acid having a trans-double bond at the 2-position.


The all-cis-isomer of a C22 polyunsaturated fatty acid having four double bonds in the 7-, 10-, 13- and 16-positions. One of the most abundant fatty acids in the early human brain.


laetisaric acid

A C18, straight-chain, hydroxy fatty acid composed of linoleic acid having an (R)-hydroxy group at the 8-position.


An omega-6 fatty acid that is hexatriacontanoic acid having four double bonds located at positions 21, 24, 27 and 30 (the 21Z,24Z,27Z,30Z-isomer).


(9Z,12E)-octadecadienoic acid

An octadecadienoic acid having two double bonds located at positions 9 and 12 (the 9Z,12E-geoisomer).


trans-pent-2-enoic acid

A pent-3-enoic acid in trans- configuration.


hexacosapentaenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any five positions of a 26-carbon straight chain.


(9Z,12Z)-hexadecadienoic acid

A hexadecadienoic acid in which the two double bonds are located at positions 9 and 12 (the 9Z,12Z-isomer).


octadecenediynoic acid

Any C18 polyunsaturated fatty acid containing one C=C and two C#C bonds at unspecified positions.


trans-parinaric acid

The all-trans- isomer of parinaric acid.


(5Z,8Z)-octadecadienoic acid

An octadecadienoic acid having two double bonds located at positions 5 and 8 (the 5Z,8Z-geoisomer).


(10E,12Z)-octadecadienoic acid

An octadeca-10,12-dienoic acid having (10E,12Z)-configuration.


trans-2-pentadecenoic acid

A pentadecenoic acid in which the olefinic double bond is at position 2 and has E configuration.


NERVONIC ACID

A tetracosenoic acid having a cis-double bond at position 15.


(2E)-15-hydroxypentadec-2-enoic acid

An omega-hydroxy fatty acid that is trans-2-pentadecenoic acid in which one of the hydrogens of the terminal methyl group has been replaced by a hydroxy group.


2-oxohexanoic acid

A straight-chain fatty acid consisting of hexanoic acid having an oxo group at position 2.


A very long-chain omega-6 fatty acid that is octatriacontanoic acid having four double bonds located at positions 23, 26, 29 and 32 (the 23Z,26Z,29Z,32Z-isomer).


docosatetraenoic acid

Any straight-chain, C22 fatty acid having four C=C double bonds.


3-decenoic acid

A decenoic acid having its double bond in the 3-position.


5-oxohexanoic acid

A medium-chain fatty acid comprising hexanoic acid carrying a 5-oxo group.


Head and Neck Disorder

description: A non-neoplastic or neoplastic disorder that affects the anatomic structures of the head and neck region.  This category includes inflammatory disorders, benign neoplasms, precancerous conditions, and malignant neoplasms.


Thyroid Gland Lipoadenoma

description: A thyroid gland adenoma composed of follicular structures and mature adipocytes.


Nasopharyngeal Paraganglioma

description: An extra-adrenal paraganglioma arising from the nasopharynx and nose.  Epistaxis or nasal obstruction are common presenting symptoms.


Malignant Maxillofacial Neoplasm

description: A primary or metastatic malignant neoplasm that affects a maxillofacial bone.


Follicular ameloblastoma

description: A histologic variant of conventional ameloblastoma characterized by the presence of odontogenic epithelial islands in a fibrotic stroma.


name: Recurrent Malignant Neoplasm of Salivary Gland

description: The reemergence of a malignant salivary gland neoplasm after a period of remission.


Skull Base Carcinoma

description: A carcinoma that arises from the base of the skull.


Malignant odontogenic tumor

description: A sarcoma that arises from tooth-forming tissues.


Sellar Neurocytoma

description: A rare extraventricular neurocytoma (WHO grade 2) of the hypothalamic-pituitary area. (WHO 2017)


Squamous odontogenic tumor

description: A rare, locally invasive neoplasm arising from tooth-forming tissues. It usually grows intraosseously in the mandible. The maxilla is less frequently involved. It is characterized by the presence of well differentiated squamous cells which form islands. Recurrences may rarely occur and probably are related to incomplete excision of the tumor.


name: Middle Ear Exophytic Sinonasal-Type Papilloma

description: An exophytic papilloma that arises from the middle ear and resembles an exophytic sinonasal papilloma.


Malignant Ameloblastoma

description: A rare, well differentiated, cytologically benign ameloblastoma which paradoxically metastasizes.


Jaw Osteoblastoma

description: An osteoblastoma that arises from the jaw. It affects the mandible more often than the maxilla.


Oral Intraepithelial Neoplasia

description: A precancerous neoplastic process affecting the oral mucosa. It is characterized by the presence of dysplasia in the mucosal epithelium.


name: Thyroid Gland Follicular Tumor of Uncertain Malignant Potential

description: An encapsulated or well-circumscribed thyroid gland tumor composed of well-differentiated follicular cells with no nuclear features of papillary thyroid carcinoma and with questionable capsular or vascular invasion. This is a tumor indeterminate between follicular adenoma and follicular carcinoma. (WHO)


Non-Neoplastic Laryngeal Disorder

description: A non-neoplastic pathologic process that affects the larynx.  Representative examples include laryngitis, vocal cord nodule, and laryngeal cleft.


Odontogenic Fibroma, Ossifying Subtype

description: A central odontogenic fibroma characterized by the presence of odontogenic fibroma components admixed with ossifying fibroma-like tissue.


name: Advanced Malignant Head and Neck Neoplasm

description: A malignant neoplasm that arises from the head and neck region and has spread extensively to other anatomic sites or is no longer responding to treatment.


Head and Neck Precancerous Condition

description: A premalignant pathologic process that affects the anatomic structures of the head and neck.  Representative examples include oral leukoplakia and leukoplakia of the vocal cords.


Nontoxic diffuse goiter

description: A diffuse goiter that is not associated with changes in thyroid function or malignancy.


Sellar Yolk Sac Tumor

description: A yolk sac tumor that arises from or adjacent to the sellar region.


Non-Neoplastic Oral Disorder

description: A non-neoplastic disorder that affects the oral cavity or the lips.


Polyp of nasal sinus

description: A polyp that arises from the paranasal sinus mucosa. Causes include allergic rhinitis, chronic sinusitis, and cystic fibrosis. It is characterized by the presence of edematous tissue infiltrated by inflammatory cells, including eosinophils.


name: Minor Salivary Gland Intraductal Papillary Neoplasm

description: A rare papillary neoplasm that grows within and is limited to the duct system of the minor salivary glands. This category includes papillary cystadenoma, ductal papilloma (including the intraductal and inverted variants), sialadenoma papilliferum, and intraductal papillary mucinous neoplasm.


Oral Cavity Schwannoma

description: A schwannoma that arises from the oral cavity.


Iodine-induced hyperthyroidism

description: Iodine-induced hyperthyroidism.


Low Risk Thyroid Gland Neoplasm

description: A thyroid gland neoplasm in which the incidence of metastatic spread is extremely low. This category includes thyroid gland noninvasive follicular neoplasm with papillary-like nuclear features, thyroid gland hyalinizing trabecular tumor, and thyroid gland tumors of uncertain malignant potential.


Sellar Paraganglioma

description: An extremely rare paraganglioma arising from chief cells of the dispersed paraganglia of the sellar region. (WHO)


Metastatic malignant neoplasm to orbit

description: A malignant neoplasm that has spread to the orbit from another anatomic site.


Congenital thyroid disorder

description: A thyroid gland disorder present at birth. It includes thyroid gland aplasia and thyroid gland hypoplasia, both result in hypothyroidism.


Sellar Immature Teratoma

description: An immature teratoma that arises from or adjacent to the sellar region.


name: Congenital hypothyroidism with ectopic thyroid

description: Thyroid hormone deficiency present at birth that is associated with ectopic thyroid tissue located in the neck region.


Jugular Foramen Neoplasm

description: A neoplasm that affects the jugular foramen.  Representative examples include paraganglioma, schwannoma, and meningioma.


Salivary Gland Sebaceous Lymphadenoma

description: A rare, benign epithelial neoplasm composed of irregular proliferating nests and islands of epithelium, including solid and gland-like sebaceous elements, surrounded by lymphoid stroma. Most occur in the parotid gland. Symptoms include a progressively enlarging, painless mass.  Sebaceous lymphadenocarcinoma is the malignant counterpart.


Benign Sinonasal Neoplasm

description: A neoplasm that arises from the nasal cavity and paranasal sinuses and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Hard Palate Monomorphic Adenoma

description: A benign epithelial neoplasm arising from the minor salivary glands in the hard palate. It is characterized by the presence of a monomorphic cellular infiltrate.


Malignant Parapharyngeal Neoplasm

description: A primary or metastatic malignant neoplasm that affects the parapharyngeal space.


Benign Inner Ear Neoplasm

description: A neoplasm that arises from the inner ear and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include vestibular schwannoma and lipoma.


Non-Neoplastic Tonsillar Disorder

description: A non-neoplastic disorder that affects the tonsils.


Non-Neoplastic Nasal Cavity Disorder

description: A non-neoplastic disorder that affects the nasal cavity.  Representative examples include rhinitis and Wegener granulomatosis.


Atypical Parathyroid Gland Tumor

description: A parathyroid gland tumor that shares certain morphologic characteristics with parathyroid gland carcinomas (e.g. broad fibrous bands formation with or without hemosiderin deposition, presence of mitotic figures) but lacks unequivocal evidence of capsular or vascular invasion. It is considered a tumor of uncertain malignant potential. (WHO)


Disorder of neck

description: A non-neoplastic or neoplastic disorder that affects the anatomic structures of the neck region.  This category includes disorders of the pharynx, larynx, thyroid gland, and parathyroid gland.


name: Metastatic Malignant Head and Neck Neoplasm

description: A malignant neoplasm that arises from the head and neck region and has spread to another anatomic site.


Odontogenic tumor, benign

description: A benign, slow growing neoplasm arising from tooth-forming tissues. It occurs in the maxillofacial skeleton or the gingiva. Representative examples include adenomatoid odontogenic tumor, calcifying cystic odontogenic tumor, and squamous odontogenic tumor.


Benign neoplasm of orbit

description: A neoplasm that arises from the orbit and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Iatrogenic Central Hypothyroidism

description: Central hypothyroidism due to medical or surgical treatment.


Ear Osteoma

description: An osteoma that arises from the bony cortex of the external auditory canal and, rarely, the middle ear.


Congenital hyperthyroidism

description: Hyperthyroidism, the cause of which is present at birth.


Sellar Meningioma

description: A rare meningioma that arises from the sellar region.


Rhinosinusitis

description: Inflammation of the mucous membranes lining the nose and paranasal sinuses.


Malignant Head and Neck Germ Cell Tumor

description: An exceptionally rare malignant germ cell tumor that arises from the head and neck region. It usually affects the sinonasal tract and nasopharynx.


Non-Neoplastic Thyroid Gland Disorder

description: A non-neoplastic disorder that affects the thyroid gland.  Representative examples include hyperthyroidism, hypothyroidism, thyroiditis, and thyroid gland abscess.


Parapharyngeal Neoplasm

description: A benign or malignant neoplasm that affects the parapharyngeal space.


Singers' nodes

description: A non-neoplastic growth in the vocal cord. It is characterized by tissue swelling in both vocal cords in a symmetrical manner. It is caused by vocal abuse behavior. Hoarseness is the presenting symptom.


Mucositis following radiation therapy

description: Inflammation of the mouth mucosa caused by head and neck radiation therapy.  Signs and symptoms include dry mouth due to lack of saliva, mucosal ulcerations and diffuse erythema of the mouth, taste alteration, and dysphagia.


Nasopharyngeal Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the nasopharynx.


Suprasellar germ cell tumor

description: A germ cell tumor that arises from the suprasellar region.


Ameloblastic Fibrosarcoma

description: A locally aggressive malignant neoplasm arising from odontogenic tissue. It occurs in the mandible and less often in the maxilla.  It is characterized by the presence of a malignant connective tissue component and a benign epithelial component.  The frequency of distal metastases is low.


Sellar Germinoma

description: A germinoma that arises from or adjacent to the sellar region.


Ceruminous Neoplasm

description: An adenoma or carcinoma that arises from the ceruminous glands in the external auditory canal.


Laryngeal Precancerous Condition

description: A premalignant pathologic process that affects the epithelial cells of the laryngeal mucosa.


Non-Neoplastic Neck Disorder

description: A non-neoplastic disorder that affects the anatomic structures of the neck region.  This category includes non-neoplastic disorders of the pharynx, larynx, thyroid gland, and parathyroid gland.


Ameloblastic fibroma

description: A rare neoplasm arising from tooth-forming tissues. It usually arises from the posterior mandible. It is characterized by the presence of an epithelial component and fibromyxoid stroma. It may recur and rarely shows malignant transformation to ameloblastic fibrosarcoma. It is treated with enucleation and curettage.


Nasal Cavity Exophytic Papilloma

description: A benign nasal cavity exophytic papillary neoplasm with fibrovascular cores lined by epithelial cells. It arises from the lower anterior nasal septum. Clinical manifestations include nasal obstruction, epistaxis, and the presence of a mass.


Leukoplakia of lips

description: A clinical term that indicates the presence of a white patch on the surface of the lip which cannot be characterized as any other disease.  It may be a precancerous condition and in most cases histologic examination reveals keratosis.


Parotid monomorphic adenoma

description: A benign epithelial neoplasm that arises from the parotid gland. It is characterized by the presence of a monomorphic cellular infiltrate.


Benign Anterior Tongue Neoplasm

description: A neoplasm that arises from the anterior portion of tongue and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Benign Ameloblastoma

description: An ameloblastoma that does not recur or metastasize.


Oral neoplasm malignant recurrent

description: Reemergence of a lip or oral cavity malignant neoplasm after a period of remission.


Nasopharyngeal Germ Cell Tumor

description: An exceptionally rare benign or malignant germ cell tumor that arises from the nasopharynx.


Nasopharyngeal Lymphoma

description: A lymphoma that arises from the nasopharynx.


Oral Cavity Neurofibroma

description: A neurofibroma that arises from the oral cavity. The tongue is the most frequently affected site.


Central Hyperthyroidism

description: Overproduction of thyroid hormones due to a disorder originating within the hypothalamic-pituitary axis.


Thyroglobulin Deficiency

description: Subnormal production of thyroglobulin, the glycoprotein precursor of thyroid hormones, presumed to result from loss-of-function mutation(s) in the TG gene.


Tongue Neurofibroma

description: A neurofibroma that arises from the tongue.


name: Head and Neck Langerhans Cell Histiocytosis

description: Langerhans cell histiocytosis involving the head and neck.


sarcoma of oral cavity

description: A malignant soft tissue neoplasm that arises from the oral cavity.  Representative examples include Kaposi sarcoma and angiosarcoma.


Nasopharyngeal Hodgkin Lymphoma

description: A Hodgkin lymphoma that arises from the nasopharynx.


Defective Thyroglobulin Transport

description: Impairment in the intracellular transport of thyroglobulin.


name: Paranasal sinus and nasal cavity malignant neoplasm

description: A primary or metastatic malignant neoplasm involving the nasal cavity and paranasal sinuses.


Oropharyngeal Hodgkin Lymphoma

description: A Hodgkin lymphoma that arises from the oropharynx.


Extraosseous/Peripheral Ameloblastoma

description: An ameloblastoma that arises from the soft tissues in the gingiva or alveolar mucosa.  It presents as a painless exophytic mass.


Sinonasal Seromucinous Hamartoma

description: A benign overgrowth of indigenous seromucinous glands of the nasal cavity and paranasal sinuses. (WHO 2017)


name: Locally Advanced Malignant Head and Neck Neoplasm

description: A malignant neoplasm that arises from the head and neck region and has spread from its original site of growth to nearby tissues or lymph nodes.


name: Thyroid Gland Clear Cell Follicular Adenoma

description: A thyroid gland adenoma composed of follicular cells with cytoplasmic clearing.


Ectopic hamartomatous thymoma

description: A rare, benign, well-circumscribed or encapsulated tumor that arises from the neck and occurs in adults. It is characterized by the presence of spindle cells, epithelial islands, and adipose tissue.


Head and Neck Teratoma

description: An exceptionally rare mature or immature teratoma that arises from the head and neck region.


Parotid Gland Sialolipoma

description: A benign parotid gland neoplasm composed of mature adipose tissue and epithelial tissue.


name: Non-Neoplastic Parathyroid Gland Disorder

description: A non-neoplastic disorder that affects the parathyroid glands.  Representative examples include hyperparathyroidism and hypoparathyroidism.


Benign Parapharyngeal Neoplasm

description: A neoplasm that arises from the parapharyngeal space and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Sellar Mature Teratoma

description: A mature teratoma that arises from or adjacent to the sellar region.


Oropharyngeal Lymphoma

description: A lymphoma that arises from the oropharynx.


Head and Neck Lymphoma

description: A Hodgkin or non-Hodgkin lymphoma that arises from the head and neck region. Hodgkin lymphomas are usually located in the lymph nodes of the neck. Non-Hodgkin lymphomas usually arise from the ocular adnexa, salivary glands, larynx, and thyroid gland.


name: Thyroid Gland Rosai-Dorfman-Destombes Disease

description: Rosai-Dorfman-Destombes disease affecting the thyroid gland. It is rare and is usually accompanied by involvement of cervical lymph nodes.


name: Head and Neck Histiocytic and Dendritic Cell Neoplasm

description: A histiocytic and dendritic cell neoplasm that affects the head and neck.


Psammomatoid Ossifying Fibroma

description: A rare, benign fibro-osseous neoplasm that arises from the craniofacial skeleton. It is characterized by the presence of multiple ossicles resembling psammoma bodies in a hypercellular stroma. It usually affects individuals in their second to fourth decades. Recurrences following surgical excision have been reported in a minority of cases.


Middle Ear Papilloma

description: A rare papilloma that arises from the middle ear and resembles a sinonasal papilloma. Approximately half of the patients have concurrent sinonasal or nasopharyngeal papillomas.


Adenoma, Monomorphic

description: A benign epithelial neoplasm arising from the salivary glands. It is characterized by the presence of a monomorphic cellular infiltrate.


Non-Neoplastic Middle Ear Disorder

description: A non-neoplastic disorder that affects the middle ear.


description: An adamantinomatous craniopharyngioma that occurs in adults.


Oral Cavity Monomorphic Adenoma

description: A benign epithelial neoplasm arising from the salivary glands in the oral cavity. It is characterized by the presence of a monomorphic cellular infiltrate.


name: Thyroid Gland Follicular Adenoma with Papillary Hyperplasia

description: A thyroid gland adenoma characterized by the presence of papillae lined by cells that range from cuboidal to columnar. The papillae are usually cystic and non-branching. Aggregates of follicles may be found within the papillary structures.


Oropharyngeal Polyp

description: A benign exophytic growth that arises from the oropharynx.


Dental surface disorders

description: A disorder that affects the surface of the tooth.


Abscess of thyroid

description: A rare disorder characterized by the development of an abscess in the thyroid gland.  It usually follows an upper respiratory tract, pharyngeal, or middle ear infection.  It is usually caused by Staphylococcus or Streptococcus infection.  It presents with fever, pain, and neck mass.


Salivary gland adenoma

description: A benign adenoma that arises from the salivary gland. This group includes pleomorphic adenoma, canalicular adenoma, basal cell adenoma, and sebaceous adenoma.


Orbital Melanoma

description: A melanoma that arises from the structures of the orbit.


Adenoid Ameloblastoma

description: A rare ameloblastoma characterized by the presence of cribriform architecture and the formation of duct-like structures. Dentinoid is usually present.


name: Head and Neck Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that arises from the head and neck. It usually affects the soft tissue of the neck. The head and neck region is the most frequently involved site for malignant peripheral nerve sheath tumors, following the trunk and extremities.


Primordial Odontogenic Tumor

description: A benign odontogenic tumor composed of variably cellular loose fibrous tissue with areas similar to the dental papilla, entirely surrounded by cuboidal to columnar epithelium resembling the internal epithelium of the enamel organ. It occurs intraosseously, with a marked preference for the mandible. (WHO 2017)


Mouth Mucous Membrane Leukoplakia

description: A clinical term that indicates the presence of a white patch on the mucous membrane in the mouth which cannot be characterized as any other disease.  It may be a precancerous condition and in most cases histologic examination reveals keratosis.


Pharyngeal Melanoma

description: A melanoma that arises from the mucosal surface of the pharynx.


Benign Head and Neck Neoplasm

description: A neoplasm that arises from the head and neck and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Salivary Gland Lymphadenomas

description: A rare benign salivary gland tumor that consists of a well-circumscribed biphasic proliferation of epithelial cells and reactive lymphoid tissue. Sebaceous and non-sebaceous forms can be distinguished. (WHO 2017)


Agenesis of larynx

description: A congenital deformity in which there is no laryngeal structure.


Wolff-Chaikoff Phenomenon

description: Hypothyroidism induced by excessive levels of iodine in the blood.


ductal papilloma of salivary gland

description: A benign papillary neoplasm that arises from the salivary glands.  This category includes intraductal papilloma, inverted ductal papilloma, and sialadenoma papilliferum.


Metastatic malignant neoplasm to lip

description: A malignant neoplasm that has spread to the lip from another anatomic site.


name: Chronic thyroiditis with transient thyrotoxicosis

description: Persistent and long-standing thyroiditis associated with temporary elevations of thyroid hormones.


Posterior Tongue Neoplasm

description: A benign or malignant neoplasm that affects the base of the tongue.


Benign neoplasm of base of tongue

description: A neoplasm that arises from the base of tongue and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Ameloblastic fibrodentinoma

description: A rare neoplasm arising from tooth-forming tissues. It usually arises from the posterior mandible. It is characterized by the presence of an epithelial component, fibromyxoid stroma, and dentin formation. It is treated with enucleation and curettage. Recurrences may occur.


name: Primary Head and Neck Mucosal CD30-Positive T-Cell Lymphoproliferative Disorder

description: A spectrum of T-cell lymphoproliferative disorders that arise from the mucosal sites of the head and neck. They are characterized by the presence of CD30-positive neoplastic lymphoid cells with pleomorphic nuclei and abundant cytoplasm. Cells that resemble the hallmark cells of anaplastic large cell lymphoma are often seen. The lesions usually arise from the oral cavity and, less frequently, the conjunctiva, orbit, and nasopharynx. In most cases complete remission is achieved, following excision, with or without radiotherapy, and with or without systemic chemotherapy.


Basal Cell Ameloblastoma

description: A conventional ameloblastoma with follicular pattern in which the odontogenic epithelial islands are composed of uniform basaloid cells.


Non-Neoplastic Paranasal Sinus Disorder

description: A non-neoplastic disorder that affects the paranasal sinuses.  Representative examples include sinusitis and mucocele.


Suppurative parotitis

description: Parotitis that is caused by a bacterial agent.


Salivary Gland Striated Duct Adenoma

description: A rare benign salivary gland adenoma that arises from ducts that resemble normal striated ducts.


Sinonasal Disorder

description: A non-neoplastic or neoplastic disorder that affects the nasal cavity or paranasal sinuses.  Representative examples include inflammatory disorders, papillomas, and carcinomas.


Benign Maxillofacial Neoplasm

description: A neoplasm that arises from a maxillofacial bone and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Non-Neoplastic External Ear Disorder

description: A non-neoplastic disorder that affects the pinna and/or the ear canal.


Paranasal Sinus Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that arises from the paranasal sinuses.


Pharyngeal Mucositis

description: An inflammatory process affecting the mucous membrane of the pharynx.


Malignant Anterior Tongue Neoplasm

description: A primary or metastatic malignant neoplasm that affects the anterior portion of the tongue.


name: Maxillofacial Rhabdomyosarcoma with TFCP2 Rearrangement

description: A rhabdomyosarcoma with TFCP2 rearrangement that arises from a maxillofacial bone.


Benign neoplasm of palate

description: A non-metastasizing neoplasm that arises from the hard palate, soft palate, or uvula.


Nasopharyngeal hairy polyp

description: A benign polypoid lesion that arises from the nasopharynx. It usually affects neonates and older infants. It manifests as a pedunculated mass associated with cough, dyspnea, vomiting, or difficulty in swallowing. It is composed of ectoderm and mesoderm.


name: Recurrent Malignant Head and Neck Neoplasm

description: The reemergence of a malignant head and neck neoplasm after a period of remission.


Iatrogenic Primary Hypothyroidism

description: Primary hypothyroidism due to medical or surgical treatment.


Leukoplakia of buccal mucosa

description: A clinical term that indicates the presence of a white patch on the buccal mucosa in the mouth which cannot be characterized as any other disease.  It may be a precancerous condition and in most cases histologic examination reveals keratosis.


name: Refractory Malignant Salivary Gland Neoplasm

description: A malignant salivary gland neoplasm that is resistant to treatment.


name: Stage IVA Mucosal Melanoma of the Head and Neck AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T3-T4a, N1, M0).  T4a: Moderately advanced disease.  Tumor involves deep soft tissue, cartilage, bone, or overlying skin.  T3: Mucosal disease.  N0: No regional lymph node metastases.  N1: Tumor with regional lymph node metastases.  M0: No distant metastasis. (AJCC 7th ed.)


Dentinogenic Ghost Cell Tumor

description: A benign but locally infiltrating neoplasm arising from tooth-forming tissues. It is more often intraosseous and less frequently extraosseous and occurs in the jaw. It is characterized by the presence of ameloblastoma-like epithelium, connective tissue stroma, ghost cells, and dysplastic dentin. Wide local resection is recommended for intraosseous neoplasms and enucleation for extraosseous neoplasms.


Unresectable Craniopharyngioma

description: A craniopharyngioma that is not amenable to surgical resection.


Non-Neoplastic Pituitary Gland Disorder

description: A non-neoplastic disorder that affects the pituitary gland.  Representative examples include pituitary gland hypoplasia and apoplexy.


Sinonasal Inverted Papilloma

description: A benign neoplasm that arises from the ciliated respiratory mucosa that lines the nasal cavity or paranasal sinuses.  It results from the invagination and proliferation of epithelial cells in the underlying stroma.  Clinical manifestations include nasal obstruction, epistaxis, and anosmia. It has the tendency to recur and extend to adjacent structures.  Inverted papillomas are occasionally associated with the development or presence of carcinomas, usually squamous cell carcinomas.


Diffuse C-Cell Hyperplasia

description: A non-neoplastic proliferation of morphologically bland C-cells with a diffuse growth pattern in the thyroid gland.


Malignant tumor of palate

description: A primary or metastatic malignant neoplasm that affects the hard palate, soft palate, or uvula.


name: Oral Mucosa Langerhans Cell Histiocytosis

description: Langerhans cell histiocytosis involving the oral mucosa.


Sinonasal Ameloblastoma

description: A locally aggressive, primarily gnathic (jaw) tumor with a high propensity for recurrence. It originates wholly within the sinonasal tract, without connection to gnathic sites, arising from sinonasal epithelium and showing histological features identical to those of its counterpart originating in the jaw. (WHO 2017)


Conventional ameloblastoma

description: An intraosseous ameloblastoma that arises from the jaw, usually the mandible.  It grows slowly, invades locally, and recurs frequently.  It presents with swelling of the jaw.


Head and Neck Melanocytic Neoplasm

description: A melanocytic neoplasm that arises from the skin or mucosal sites in the head and neck region.


Parotid Gland Sebaceous Lymphadenoma

description: A rare, benign epithelial neoplasm that arises from the parotid gland.  It is composed of irregular proliferating nests and islands of epithelium, including solid and gland-like sebaceous elements, surrounded by lymphoid stroma. Patients present with a progressively enlarging and painless mass.


Lingual Thyroid Gland

description: Ectopic thyroid gland located at the base of the tongue.


Hyperthyroidism with Hashimoto disease

description: Severe, transient hyperthyroidism associated with Hashimoto thyroiditis.


canalicular adenoma of salivary gland

description: A benign epithelial neoplasm primarily composed of branching and interconnecting cords of single and double-cell thick rows of columnar epithelium in a very loose stroma. It often occurs in the upper lip, where only pleomorphic adenoma is more frequent. Asymptomatic swelling of the upper lip is the most common clinical finding. It may present clinically and histologically as a multifocal lesion, a feature not generally seen with other intraoral salivary gland tumors.


name: Thyroid Gland Spindle Cell Follicular Adenoma

description: A rare thyroid gland follicular adenoma composed predominantly of spindle cells.


Oral Verruca Vulgaris

description: Verruca vulgaris in the lips and oral cavity.


Malignant Sinonasal Germ Cell Tumor

description: An exceptionally rare malignant germ cell tumor that arises from the nasal cavity or paranasal sinuses.


Middle Ear Paraganglioma

description: A jugulotympanic paraganglioma arising from paraganglia in the middle ear.


Thyroid Gland Schwannoma

description: A rare schwannoma that arises from the thyroid gland.


Dual Oxidase 2 Deficiency

description: Thyroid peroxidase system defect due to presumed mutation(s) in the DUOX2 gene, resulting in decreased activity of dual oxidase 2.


Transient hypothyroxinemia

description: Reduced concentration of thyroid hormone(s), usually associated with a non-thyroidal illness, that resolves spontaneously.


name: Refractory Malignant Pharyngeal Neoplasm

description: Malignant pharyngeal neoplasm that is resistant to treatment.


Non-Neoplastic Head and Neck Disorder

description: A non-neoplastic disorder that affects the anatomic structures of the head and neck region.


Diffuse endemic goiter

description: A diffuse goiter caused by inadequate iodine intake.


Laryngeal Mucositis

description: An inflammatory process affecting the mucous membrane of the larynx.


Benign neoplasm of bone of skull

description: A neoplasm that arises from the bones and structures of skull and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Recurrent Skull Base Carcinoma

description: The reemergence of skull base carcinoma after a period of remission.


External Ear Actinic Keratosis

description: Actinic keratosis that develops in the skin of the external ear.


Non-Neoplastic Pharyngeal Disorder

description: A non-neoplastic disorder that affects the pharynx.  Representative examples include pharyngitis and mucositis.


name: Thyroid Gland Follicular Adenoma with Bizarre Nuclei

description: A thyroid gland adenoma containing follicular cells with large hyperchromatic nuclei.  The clinical course is benign.


Defective Thyroglobulin Synthesis

description: Impairment in the intracellular synthesis of thyroglobulin.


Parathyroid gland abscess

description: An abscess that is located in the parathyroid gland(s).


Hairy leukoplakia of tongue

description: An epithelial hyperplasia on the surface of the tongue associated with Epstein-Barr virus and found almost exclusively in persons with HIV infection. The lesion consists of a white patch that is often corrugated or hairy.


Pharyngeal Hodgkin Lymphoma

description: A Hodgkin lymphoma that arises from the pharynx.


Head and Neck Germ Cell Tumor

description: An exceptionally rare benign or malignant germ cell tumor that arises from the head and neck region. It usually affects the sinonasal tract and nasopharynx.


Congenital thyroid hypoplasia

description: Incomplete development of the thyroid gland in a newborn.


Palatine Tonsil Hamartomatous Polyp

description: A rare hamartomatous polyp that arises from the palatine tonsil.


Erythroleukoplakia

description: Leukoplakia of the oral mucosa that is clinically characterized by the presence of erythematous or red and white patches.


Thyroid Gland Paraganglioma

description: A rare, circumscribed or encapsulated neuroendocrine tumor arising from the thyroid gland. Microscopically, it is characterized by the presence of tumor cells arranged in a nesting (Zellballen) growth pattern. The reported cases have followed a benign clinical course.


Hodgkin's lymphoma of thyroid gland

description: An exceedingly rare Hodgkin lymphoma that arises from the thyroid gland.


Refractory Malignant Oral Neoplasm

description: Lip or oral cavity malignant neoplasm that is resistant to treatment.


name: Sinonasal Respiratory Epithelial Adenomatoid Hamartoma

description: A benign acquired overgrowth of indigenous glands of the sinonasal tract arising from the surface epithelium. (WHO 2017)


Non-Neoplastic Tongue Disorder

description: A non-neoplastic disorder that affects the tongue.


Sinonasal Teratoma

description: An exceptionally rare mature or immature teratoma that arises from the nasal cavity or paranasal sinuses.


Speckled oral leukoplakia

description: Non-homogenous leukoplakia on the oral mucosa.  It is associated with a high risk for malignant transformation.


Leukoplakia of tongue

description: A clinical term that indicates the presence of a white patch on the surface of the tongue which cannot be characterized as any other disease.  It may be a precancerous condition and in most cases histologic examination reveals keratosis.


Benign neoplasm of uvula

description: A non-metastasizing neoplasm that arises from the uvula.


name: Thyroid Gland Histiocytic and Dendritic Cell Neoplasm

description: A rare histiocytic and dendritic cell neoplasm that affects the thyroid gland.


name: Middle Ear Inverted Sinonasal-Type Papilloma

description: An inverted papilloma that arises from the middle ear and resembles a sinonasal inverted papilloma.


Non-Neoplastic Salivary Gland Disorder

description: A non-neoplastic disorder that affects the major or minor salivary glands.


Hodgkin's lymphoma of salivary gland

description: A very rare Hodgkin lymphoma that manifests initially in a salivary gland.


name: Minor Salivary Gland Intraductal Papillary-Mucinous Neoplasm

description: A rare, low-grade epithelial neoplasm with ductal differentiation that grows within and is limited to the duct system of the minor salivary glands. It is characterized by a proliferation of mucin-producing cells within the minor salivary gland ducts, intraductal accumulation of mucin, and a papillary growth pattern. Cytologic and architectural atypia and mitotic activity are present. AKT1 gene mutations have been identified in the majority of cases. Morphologically it resembles the intraductal papillary-mucinous neoplasms of the pancreas.


Calcifying Odontogenic Cyst

description: A benign, intraosseous or extraosseous cystic neoplasm arising from tooth-forming tissues. It is characterized by the presence of a cyst lined by an ameloblastoma-like epithelium and ghost cells formation. The ghost cells may undergo calcification. It is treated with enucleation. Few recurrences have been reported for intraosseous neoplasms whereas no recurrences have been reported for extraosseous neoplasms.


Sinonasal Lymphoma

description: A lymphoma that arises from the sinonasal tract.


name: Stage IVC Mucosal Melanoma of the Head and Neck AJCC v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Head and Neck Nevus

description: A benign nevus that arises from the skin in the head and neck region.


Leukoplakia of larynx

description: A premalignant pathologic process that affects the mucosal epithelium of the larynx.  It appears as a localized or diffuse white patch on the laryngeal mucosa.  Morphologically it is characterized by the pathologic production of keratin in the mucosal epithelial surface with or without epithelial atypia.  It may progress to or co-exist with invasive squamous cell carcinoma.


Maxillofacial Osteoblastoma

description: A benign bone-forming neoplasm with prominent osteoblastic rimming arising in a maxillofacial bone.


name: Chondrodermatitis Nodularis Chronica Helicis

description: A relatively common non-neoplastic inflammatory and degenerative lesion that affects the external ear. It is characterized by necrotic changes in the dermis and perichondrium. It usually affects the helix. Patients present with a painful nodule that contains a cup-shaped crater filled with necrotic debris, inflammatory cells, and fibrin. It is caused by helmets, headsets, actinic changes, and frostbite resulting in dermal microtraumas. It is often confused clinically with squamous or basal cell carcinoma, and it may recur.


name: Nasopharyngeal Salivary Gland Anlage Tumor

description: A rare midline nasopharyngeal lesion that affects infants. It presents with respiratory distress due to nasal airway obstruction. It is a biphasic lesion characterized by the presence of epithelial and myoepithelial components. The histological features suggest that this lesion may be a hamartoma, rather than a neoplasm.


Maxillofacial Neoplasm

description: A neoplasm that arises in a maxillofacial bone.


Sinonasal Exophytic Papilloma

description: A papilloma with an exophytic growth arising from the sinonasal track.


Disorder of vocal cord

description: A disorder affecting the vocal cords. Representative examples include vocal cord nodules, polyps, leukoplakia, dysplasia, and paralysis.


Suprasellar Germinoma

description: A germinoma that arises from the suprasellar region.


Sinonasal Neurofibroma

description: A neurofibroma that arises from the nasal cavity and paranasal sinuses.


Central odontogenic fibroma

description: A rare, benign neoplasm arising from tooth-forming tissues in the mandible and maxilla (central odontogenic fibroma); and rarely from extraosseous tissues, usually in the gingiva (peripheral odontogenic fibroma). It is characterized by the presence of odontogenic epithelium that is embedded in a fibrous stroma. Local enucleation of the tumor is curative.


Orbit Paraganglioma

description: An extra-adrenal paraganglioma arising from the orbit.  Patients may present with visual disturbances or proptosis.


Head and Neck Erdheim-Chester Disease

description: Erdheim-Chester disease that affects the head and neck region. Patients present with xanthelasma-like lesions in the face, neck, and around the eyes.


Maxillofacial Sarcoma

description: A sarcoma that arises in a maxillofacial bone.


Diffuse goiter

description: Enlargement of the entire thyroid gland without discrete mass(es).


name: Thyroid Gland Tumor of Uncertain Malignant Potential

description: An encapsulated or well-circumscribed thyroid gland tumor composed of well-differentiated follicular cells, in which capsular or vascular invasion is indeterminate.


Lymphoepithelial Sialadenitis

description: A benign salivary gland lesion characterized by acinar atrophy, ductal hyperplasia, and epimyoepithelial islands in lymphoid stroma. (WHO 2017)


name: Cystic/Microcystic Calcifying Epithelial Odontogenic Tumor

description: A calcifying epithelial odontogenic tumor characterized by cystic/microcystic changes.


Nasopharyngeal Melanoma

description: A melanoma that arises from the mucosal surface of the nasopharynx.


Neonatal hearing impairment

description: An abnormality that affects hearing within the first month after birth. It may or may not result in hearing loss.


Oral Cavity Adenoma

description: A monomorphic or pleomorphic adenoma that arises from the salivary glands in the oral cavity.


Soft Palate Benign Granular Cell Tumor

description: A granular cell tumor that arises from the soft palate and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Non-Calcifying/Langerhans Cell-Rich Calcifying Epithelial Odontogenic Tumor

description: A calcifying epithelial odontogenic tumor that contains significant numbers of Langerhans cells.


Sinonasal Germ Cell Tumor

description: An exceptionally rare benign or malignant germ cell tumor that arises from the nasal cavity or paranasal sinuses.


name: Thyroid Gland Mucinous Follicular Adenoma

description: A thyroid gland adenoma composed of follicles and characterized by the presence of abundant extracellular mucin.


Iodine Deficiency Hypothyroidism

description: Hypothyroidism due to insufficient intake of iodine.


name: Thyroid Gland Signet Ring Cell Follicular Adenoma

description: A thyroid gland adenoma characterized by the presence of signet ring cells that stain positive for thyroglobulin.


Head and Neck Neuroendocrine Neoplasm

description: A neoplasm with neuroendocrine differentiation that arises from the head and neck. This category includes neuroendocrine tumors, neuroendocrine carcinomas, and paragangliomas.


name: Thyroid Gland Langerhans Cell Histiocytosis

description: Langerhans cell histiocytosis involving the thyroid gland focally or diffusely. It is exceedingly rare and usually occurs in patients with multifocal disease.


Odontogenic Fibroma, Amyloid Subtype

description: A central odontogenic fibroma characterized by the presence of amyloid deposits. Langerhans cells are often present in the odontogenic epithelium.


Adenoma, Basal Cell

description: A salivary gland benign epithelial neoplasm with a uniform, monomorphic appearance that is dominated by basal cells forming trabecular structures. It is rare and occurs mostly on the parotid gland. The average age of patients has been reported to be 58 years. Swelling is the most constant clinical finding.


Pharyngeal Lymphoma

description: A lymphoma that arises from the pharynx.


name: Head and Neck Rosai-Dorfman-Destombes Disease

description: Rosai-Dorfman-Destombes disease that affects the head and neck region. It usually affects the cervical lymph nodes. Extranodal head and neck sites of involvement include the orbit, oral cavity, nasal cavity, and paranasal sinuses.


name: Stage III Mucosal Melanoma of the Head and Neck AJCC v7

description: Stage III includes: T3, N0, M0.  T3: Mucosal disease N0: No regional lymph node metastases.  M0: No distant metastasis. (AJCC 7th ed.)


name: Head and Neck Hematopoietic and Lymphoid Cell Neoplasm

description: A neoplasm of hematopoietic and lymphoid cell origin that affects the head and neck region.


name: Thyroid Gland Follicular Nodular Disease

description: A benign, non-inflammatory, multifocal proliferation of thyroid follicular cells that results in the formation of multiple thyroid nodules. The clinical term multinodular goiter refers to the changes caused in the thyroid gland by follicular nodular disease.


name: neoplasm of anterior dorsal surface of tongue

description: A benign or malignant neoplasm that affects the anterior portion of the tongue.


Parotid Gland Keratocystoma

description: A benign neoplasm that arises from the parotid gland. It is characterized by the presence of multicystic formations, lined by neoplastic stratified squamous epithelium and containing keratotic lamellae. The neoplastic squamous epithelial cells have bland nuclei and abundant eosinophilic cytoplasm. Focally, solid islands of squamous cells surrounded by collagenous stroma are present.


Salivary Gland Infection

description: A viral (such as mumps) or bacterial infectious process affecting the salivary gland. The salivary gland becomes enlarged and is often painful.


name: Refractory Malignant Head and Neck Neoplasm

description: A malignant head and neck neoplasm that is resistant to treatment.


Head and Neck Myeloid Sarcoma

description: A rare myeloid sarcoma that arises from the head and neck region. The oral cavity is the most frequently affected site.


name: Hybrid Odontogenic Fibroma with Central Giant Cell Granuloma

description: A central odontogenic fibroma characterized by the presence of combined histological features of giant cell granuloma and odontogenic fibroma.


Disorder of tonsil (palatine tonsil)

description: A non-neoplastic or neoplastic disorder that affects the tonsils.


name: inverted ductal papilloma of salivary gland

description: A very rare benign tumor of the minor salivary glands, characterized by a luminal papillary proliferation that arises at the junction of the salivary gland duct and the oral mucosal surface epithelium and expands as a nodular mass into the lamina propria.  It presents as an asymptomatic mucosal swelling.


Unicystic ameloblastoma

description: An ameloblastoma that presents as a unilocular cyst.  It usually arises from the mandible.


Sellar ependymoma

description: A very rare, low-grade neoplasm that arises from the posterior pituitary. It is composed of epithelioid and oncocytic cells forming sheets and fascicles. It shows histopathological features reminiscent of ependymomas, including perivascular pseudorosettes and true rosettes. There is no evidence of necrosis or increased mitotic activity. Despite the presence of ependymal histopathological features, these neoplasms probably are not related to ependymomas. Their prognosis is unknown.


Benign neoplasm of accessory sinus

description: A neoplasm that arises from the paranasal sinuses and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include Schneiderian papilloma and salivary gland-type adenoma.


Oral Cavity Myeloid Sarcoma

description: An extramedullary myeloid tumor that arises from the oral cavity. It occurs de novo or can precede, coincide with, or follow the presentation of acute myeloid leukemia, or can constitute blastic transformation of a myelodysplastic syndrome or myeloproliferative neoplasm. (WHO 2017)


Necrotizing Sialometaplasia

description: A reactive and self-limiting inflammation of the salivary glands that results in degeneration and necrosis of salivary acini and ductal squamous metaplasia. It usually affects the minor salivary glands in the posterolateral hard palate. It is probably caused by trauma and hypoxia.


Malignant Inner Ear Neoplasm

description: A malignant neoplasm that affects the inner ear.


Benign Skull Base Neoplasm

description: A neoplasm that arises the skull base and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Stage IVB Mucosal Melanoma of the Head and Neck AJCC v7

description: Stage IVB includes: T4b, Any N, M0.  T4b: Very advanced disease.  Tumor involves brain, dura, skull base, lower cranial nerves (IX, X, XI, XII), masticator space, carotid artery, prevertebral space, or mediastinal structures.  M0: No distant metastasis. (AJCC 7th ed.)


name: Metastatic Malignant Neoplasm in the Head and Neck

description: The spread of a malignant neoplasm to the head and neck.  This may be from a primary head and neck malignant neoplasm, or from a malignant neoplasm at a distant site.


Recurrent Sinonasal Inverted Papilloma

description: The reemergence of inverted Schneiderian papilloma after a period of remission.


Thyroid Gland Hyperfunctioning Adenoma

description: A thyroid gland adenoma producing thyroxin.  It is associated with hyperthyroidism.  Radioactive iodine scan reveals a hot nodule.


Adult Craniopharyngioma

description: A craniopharyngioma that occurs during adulthood.  It can be either adamantinomatous or papillary.  The papillary histologic variant occurs virtually exclusively in adults.  Clinical signs and symptoms include visual disturbances and endocrine deficiencies.


Acquired Hyperthyroidism

description: Hyperthyroidism, the cause of which is not present from birth.


name: Thyroid Gland Follicular Adenoma with Papillary Architecture

description: A benign, encapsulated thyroid gland neoplasm characterized by the presence of large follicles with intrafollicular papillary architecture. The cells lining the papillae are usually columnar. It is usually a cystic neoplasm and lacks nuclear atypia and capsular invasion. Psammoma bodies are not present. Activating TSHR mutations have been described in the majority of cases. In a small number of cases GNAS mutations have been identified.


name: Malignant Nasopharyngeal Germ Cell Tumor

description: An exceptionally rare malignant germ cell tumor that arises from the nasopharynx.


Non-Neoplastic Inner Ear Disorder

description: A non-neoplastic disorder that affects the inner ear.  Representative examples include infection and sensory hearing loss.


Thyroid Gland Solitary Fibrous Tumor

description: A rare solitary fibrous tumor that arises from the thyroid gland.


Lymphocytic Neurohypophysitis

description: An autoimmune condition affecting the posterior pituitary gland, which is characterized by lymphocytic infiltration, and which often presents as diabetes insipidus.


Squamous cell papilloma of oral cavity

description: A benign, exophytic and polypoid growth that arises from the lips or oral cavity. It is covered by hyperplastic epithelium. Some cases are caused by human papillomavirus infection.


Odontogenic myxoma

description: An intraosseous odontogenic neoplasm with good prognosis, arising from the mandible and less frequently from the maxilla. It is characterized by the presence of stellate cells, myxoid stroma formation, and prominent collagen. Small tumors may be cured with enucleation. Complete excision may be required for larger tumors.


Interarytenoid leukoplakia

description: A clinical term that indicates the presence of a white mucosal patch in the interarytenoid area.  In most cases histologic examination reveals keratosis.


Head and Neck Juvenile Xanthogranuloma

description: A benign histiocytic tumor that usually arises from the skin of the head and neck and occurs during childhood. It is distinct from Langerhans cell histiocytosis. Rarely, it can arise from extracutaneous head and neck sites, including the eye, ocular adnexa, oral cavity, paranasal sinuses, and ear. It is characterized by the presence of lipid-laden, foamy histiocytes and Touton-type giant cells.


Aneuploid Dysplastic Oral Leukoplakia

description: Oral leukoplakia associated with advanced dysplasia in which genetic studies show aneuploidy.  The vast majority of patients develop aggressive invasive squamous cell carcinomas.  Complete resection of the lesion does not reduce the risk of developing invasive squamous cell carcinoma.


Non-Neoplastic Oral Cavity Disorder

description: A non-neoplastic disorder that affects the oral cavity.  Representative examples include inflammation, fibroepithelial polyp, and cleft palate.


Acquired central hypothyroidism

description: Central hypothyroidism, the cause of which is not present at birth.


Recurrent Malignant Pharyngeal Neoplasm

description: Reemergence of a malignant pharyngeal neoplasm after a period of remission.


Atrophy of thyroid - acquired

description: Atrophy of the thyroid gland, the cause of which is not present at birth.


Sclerosing Polycystic Adenosis

description: A rare, benign, well-circumscribed salivary gland neoplasm that predominantly affects females.  It is characterized by the presence of microcysts, ducts, and acini in a sclerotic stroma.  Focal lymphocytic infiltrates may also be present.


Osteoma of skull

description: A benign bone-forming neoplasm arising from the skull.


Mucosal Melanoma of the Head and Neck

description: A melanoma that arises in the mucosa of the nasal cavity, paranasal sinuses, oral cavity, oropharynx, nasopharynx, larynx, and hypopharynx.


Fibro-odontoma, Ameloblastic

description: A rare benign neoplasm arising from tooth-forming tissues. It is characterized by the presence of a fibromyxoid stroma, epithelial component, dentin, and enamel. Recurrences are rare.


Non-toxic nodular goiter

description: Sporadic nodular enlargement of the thyroid gland that is not associated with changes in thyroid function or malignancy.


Non-Neoplastic Gingival Disorder

description: A non-neoplastic disorder that affects the gums.


Maxillofacial Osteoma

description: A benign, well-circumscribed bone-forming neoplasm arising in a maxillofacial bone.


Reactive C-Cell Hyperplasia

description: A non-neoplastic proliferation of C-cells in the thyroid gland caused by external stimuli such as hypercalcemia and chronic lymphocytic thyroiditis.


Transient Primary Hypothyroidism

description: Primary hypothyroidism that resolves spontaneously.


Sellar Teratoma

description: A teratoma that arises from or adjacent to the sellar region.


Acanthomatous ameloblastoma

description: A conventional ameloblastoma with follicular pattern in which the central cells in the odontogenic epithelial islands show squamous differentiation.


Tonsillopharyngitis

description: Inflammation of the palatine tonsils and the posterior pharynx (throat).


Leukoplakia of vocal cords

description: A clinical term that indicates the presence of a white patch on the mucosal surface of the vocal cords.  In most cases histologic examination reveals keratosis.


Intrasellar Meningioma

description: A rare meningioma arising from the intrasellar region.


Sinonasal Schwannoma

description: A schwannoma that arises from the nasal cavity and paranasal sinuses.


Ameloblastic Fibroodontosarcoma

description: An odontogenic sarcoma producing enamel/enameloid and dentin.


name: Oral Cavity and Lip Precancerous Condition

description: A premalignant pathologic process that affects the mucosa surface of the oral cavity or lip.  It includes leukoplakia, erythroplakia, and smoker's keratosis.


Head and Neck Hodgkin Lymphoma

description: A Hodgkin lymphoma that affects the head and neck region. It is usually located in the lymph nodes of the neck.


Tongue Schwannoma

description: A schwannoma that arises from the tongue.


Oral Cavity Granular Cell Tumor

description: A rare neoplasm that arises from the oral cavity, usually the tongue.  It is characterized by the presence of plump eosinophilic cells with abundant granular cytoplasm.  The neoplastic cells extend into the surrounding tissues, usually skeletal muscle.  The vast majority of cases follow a benign clinical course.  Recurrences are rare after removal of the tumor.


name: Recurrent Malignant Thyroid Gland Neoplasm

description: The reemergence of malignant thyroid gland neoplasm after a period of remission.


name: Refractory Malignant Thyroid Gland Neoplasm

description: Malignant thyroid gland neoplasm that is resistant to treatment.


Jaw Osteosarcoma

description: An osteosarcoma that arises from the jaw. It affects the mandible more often than the maxilla.


Head and Neck Liposarcoma

description: A liposarcoma that arises from the head and neck. The majority affect the subcutaneous connective tissue of the face, neck, and scalp.


Thyroid Gland Black Follicular Adenoma

description: A thyroid gland follicular adenoma seen in patients treated with minocycline. The tumors have black discoloration visible on macroscopic examination and cytoplasmic accumulation of black pigment. (WHO 2017)


name: Head and Neck Follicular Dendritic Cell Sarcoma

description: A follicular dendritic cell sarcoma that arises from the head and neck. The most frequently affected sites are the cervical lymph nodes, the Waldeyer ring, and the soft tissue of the neck.


name: Middle Ear Oncocytic Sinonasal-Type Papilloma

description: An oncocytic papilloma that arises from the middle ear and resembles an oncocytic sinonasal papilloma.


Recurrent Craniopharyngioma

description: The reemergence of a craniopharyngioma after a period of remission.


Granular cell ameloblastoma

description: A conventional ameloblastoma with follicular pattern in which the odontogenic epithelial islands contain granular cells.


name: Mucosal Melanoma of the Head and Neck by AJCC v7 Stage

description: A term that refers to the staging of mucosal melanoma of the head and neck according to the American Joint Committee on Cancer, 7th edition. No prognostic stage grouping is proposed in the 8th edition.


Sinonasal Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that arises from the sinonasal tract.


Non-Neoplastic Sinonasal Disorder

description: A non-neoplastic disorder that affects the nasal cavity or paranasal sinuses.  Representative examples include rhinitis, sinusitis, and mucocele.


Sellar Schwannoma

description: An extremely rare schwannoma that arises from the sellar region.


Hypothyroid Goiter

description: Goiter associated with reduced thyroid hormone secretion.


Sialoblastoma

description: A rare, malignant primitive neoplasm that occurs in the salivary glands. Most tumors arise from the parotid gland, followed by the submandibular gland, and rarely the minor salivary glands. It is usually diagnosed during the neonatal period and presents with painless face swelling.


Lymphedema of the Head and Neck

description: Lymphedema that manifests in the head and neck.


Central Odontogenic Fibroma

description: An odontogenic fibroma that arises from tooth-forming tissues in the mandible and maxilla.


Choanal polyp

description: A benign exophytic growth that arises from the nasopharynx.


Thyroid Gland Teratoma

description: A teratoma that arises from the thyroid gland. Thyroid gland teratomas with high grade/malignant histological features carry DICER1 gene mutations and have been reclassified as thyroblastomas. They are no longer considered true teratomas.


name: Salivary Gland Intercalated Duct Adenoma

description: A benign, well-circumscribed or encapsulated neoplasm that arises from the salivary glands, usually the parotid. It is characterized by nodular and less often multinodular proliferation of cuboidal ductal cells and attenuated myoepithelial cells, resembling bi-layered intercalated ducts. Most lesions are incidental findings, usually measuring less than 5 mm.