name: XRCC1_HUMAN DNA repair protein XRCC1 (sprot)

description: A DNA repair protein XRCC1 that is encoded in the genome of human.


name: DLK1_HUMAN Protein delta homolog 1 (sprot)

description: A protein delta homolog 1 that is encoded in the genome of human.


isoniazid

A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine.


name: RL17_HUMAN Large ribosomal subunit protein uL22 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL22 that is encoded in the genome of human.


BENZIMIDAZOLE

The 1H-tautomer of benzimidazole.


name: IGF1_HUMAN Insulin-like growth factor I (sprot)

description: An insulin-like growth factor I that is encoded in the genome of human.


asthma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.


corticosterone

A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.


UCN3_HUMAN Urocortin-3 (sprot)

A urocortin-3 that is encoded in the genome of human.


name: A4_HUMAN Amyloid-beta precursor protein (sprot)

description: An amyloid-beta precursor protein that is encoded in the genome of human.


name: GRIA1_HUMAN Glutamate receptor 1 (sprot)

description: A glutamate receptor 1 that is encoded in the genome of human.


BTG1_HUMAN Protein BTG1 (sprot)

A protein BTG1 that is encoded in the genome of human.


name: PP2BA_HUMAN Protein phosphatase 3 catalytic subunit alpha (sprot)

description: A protein phosphatase 3 catalytic subunit alpha that is encoded in the genome of human.


name: MACC1_HUMAN Metastasis-associated in colon cancer protein 1 (sprot)

description: A metastasis-associated in colon cancer protein 1 that is encoded in the genome of human.


name: TISD_HUMAN mRNA decay activator protein ZFP36L2 (sprot)

description: An mRNA decay activator protein ZFP36L2 that is encoded in the genome of human.


name: MTOR_HUMAN Serine/threonine-protein kinase mTOR (sprot)

description: A serine/threonine-protein kinase mTOR that is encoded in the genome of human.


estradiol

The 17beta-isomer of estradiol.


name: MASP2_HUMAN Mannan-binding lectin serine protease 2 (sprot)

description: A mannan-binding lectin serine protease 2 that is encoded in the genome of human.


palbociclib

A member of the class of pyridopyrimidines that is 2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7-one bearing additional methyl, acetyl and cyclopentyl substituents at positions 5, 6 and 8 respectively. It is used in combination with letrozole for the treatment of metastatic breast cancer.


name: FABD_HUMAN Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (sprot)

description: A malonyl-CoA-acyl carrier protein transacylase, mitochondrial that is encoded in the genome of human.


neurodegenerative disease

description: A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function.


cortisol

A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses.


agoraphobia

description: An anxiety disorder characterized by an intense, irrational fear of venturing out into open places or situations in which help (or escape) might not be available should excessive anxiety or panic symptoms develop.


name: KI67_HUMAN Proliferation marker protein Ki-67 (sprot)

description: A proliferation marker protein Ki-67 that is encoded in the genome of human.


name: WDR1_HUMAN WD repeat-containing protein 1 (sprot)

description: A WD repeat-containing protein 1 that is encoded in the genome of human.


Fever

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Body temperature elevated above the normal range.


A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.


exocrine pancreatic carcinoma

description: A carcinoma that arises from epithelial cells of the exocrine pancreas


ovarian neoplasm

description: A benign, borderline, or malignant neoplasm involving the ovary.


curcumin

A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.


name: TCF15_HUMAN Transcription factor 15 (sprot)

description: A transcription factor 15 that is encoded in the genome of human.


pancreatic adenocarcinoma

description: A carcinoma that arises from glandular epithelial cells of the pancreas


gefitinib

A member of the class of quinazolines that is quinazoline which is substituted by a (3-chloro-4-fluorophenyl)nitrilo group, 3-(morpholin-4-yl)propoxy group and a methoxy group at positions 4,6 and 7, respectively. An EGFR kinase inhibitor used for the treatment of non-small cell lung cancer.


kidney disorder

description: A disease involving the kidney.


name: SIR7_HUMAN NAD-dependent protein deacetylase sirtuin-7 (sprot)

description: An NAD-dependent protein deacetylase sirtuin-7 that is encoded in the genome of human.


name: EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (sprot)

description: A histone-lysine N-methyltransferase EZH2 that is encoded in the genome of human.


retinoic acid

A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).


PRLR_HUMAN Prolactin receptor (sprot)

A prolactin receptor that is encoded in the genome of human.


name: MTMR2_HUMAN Myotubularin-related protein 2 (sprot)

description: A myotubularin-related protein 2 that is encoded in the genome of human.


name: MTMR5_HUMAN Myotubularin-related protein 5 (sprot)

description: A myotubularin-related protein 5 that is encoded in the genome of human.


docosahexaenoic acid

A docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19.


IL5_HUMAN Interleukin-5 (sprot)

An interleukin-5 that is encoded in the genome of human.


amphotericin B

A macrolide antibiotic used to treat potentially life-threatening fungal infections.


brain disorder

description: A disease affecting the brain or part of the brain.


name: ROCK2_HUMAN Rho-associated protein kinase 2 (sprot)

description: A Rho-associated protein kinase 2 that is encoded in the genome of human.


NEST_HUMAN Nestin (sprot)

A nestin that is encoded in the genome of human.


IL1B_HUMAN Interleukin-1 beta (sprot)

An interleukin-1 beta that is encoded in the genome of human.


name: LHX6_HUMAN LIM/homeobox protein Lhx6 (sprot)

description: A LIM/homeobox protein Lhx6 that is encoded in the genome of human.


CTNB1_HUMAN Catenin beta-1 (sprot)

A catenin beta-1 that is encoded in the genome of human.


colorectal cancer

description: A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma.


sulfamethoxazole

An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.


Recurrent urinary tract infections

description: Repeated infections of the urinary tract.


butyric acid

A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.


CP7A1_HUMAN Cytochrome P450 7A1 (sprot)

A cytochrome P450 7A1 that is encoded in the genome of human.


name: KPCE_HUMAN Protein kinase C epsilon type (sprot)

description: A protein kinase C epsilon that is encoded in the genome of human.


sirolimus

A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.


name: GFI1_HUMAN Zinc finger protein Gfi-1 (sprot)

description: A zinc finger protein Gfi-1 that is encoded in the genome of human.


name: PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (sprot)

description: A poly [ADP-ribose] polymerase 1 that is encoded in the genome of human.


name: TPH2_HUMAN Tryptophan 5-hydroxylase 2 (sprot)

description: A tryptophan 5-hydroxylase 2 that is encoded in the genome of human.


name: AL1L1_HUMAN Cytosolic 10-formyltetrahydrofolate dehydrogenase (sprot)

description: A 10-formyltetrahydrofolate dehydrogenase that is encoded in the genome of human.


PORICOIC ACID A

A tricyclic triterpenoid isolated from Poria cocos.


name: KEAP1_HUMAN Kelch-like ECH-associated protein 1 (sprot)

description: A kelch-like ECH-associated protein 1 that is encoded in the genome of human.


D-erythro-biopterin

A biopterin in which the 1,2-dihydroxypropyl group has (1S,2R)-configuration.


IFNG_HUMAN Interferon gamma (sprot)

An interferon gamma that is encoded in the genome of human.


EMD_HUMAN Emerin (sprot)

An emerin that is encoded in the genome of human.


name: BAP31_HUMAN B-cell receptor-associated protein 31 (sprot)

description: A B-cell receptor-associated protein 31 that is encoded in the genome of human.


name: THA_HUMAN Thyroid hormone receptor alpha (sprot)

description: A thyroid hormone receptor alpha that is encoded in the genome of human.


name: STAT3_HUMAN Signal transducer and activator of transcription 3 (sprot)

description: A signal transducer and activator of transcription 3 that is encoded in the genome of human.


fluticasone

A trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis.


peripheral arterial disease

description: A disorder of the arteries supplying the upper and lower extremity and the visceral organs. This includes the mesenteric arteries, the renal arteries and the aorta and excludes cerebrovascular arterial disease. Patients experience cramping and pain usually in the calves and thighs while walking. The symptoms subside with rest.


ketoconazole

A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.


name: ACE2_HUMAN Angiotensin-converting enzyme 2 (sprot)

description: An angiotensin-converting enzyme 2 that is encoded in the genome of human.


name: MACD2_HUMAN ADP-ribose glycohydrolase MACROD2 (sprot)

description: An ADP-ribose glycohydrolase MACROD2 that is encoded in the genome of human.


name: TGBR3_HUMAN Transforming growth factor beta receptor type 3 (sprot)

description: A TGF-beta receptor type-3 that is encoded in the genome of human.


atorvastatin

A dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases.


Hyperfibrinogenemia

description: Increased concentration of fibrinogen in the blood.


paclitaxel

A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.


CRKL_HUMAN Crk-like protein (sprot)

A Crk-like protein that is encoded in the genome of human.


gentamicin

Any of a group of aminoglycoside antibiotics produced by fermentation of some Micromonospora spp.


Rett syndrome

description: A severe neurodevelopmental disorder affecting the central nervous system.


nitric oxide

A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.


age-related macular degeneration

description: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.


ethanol

A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.


name: PFKAM_HUMAN ATP-dependent 6-phosphofructokinase, muscle type (sprot)

description: An ATP-dependent 6-phosphofructokinase, muscle type that is encoded in the genome of human.


hepatocellular carcinoma

description: A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.


name: FRAT2_HUMAN GSK-3-binding protein FRAT2 (sprot)

description: A GSK-3-binding protein FRAT2 that is encoded in the genome of human.


CYPROHEPTADINE HYDROCHLORIDE

The hydrochloride salt of cyproheptadine. Note that the drug named cyproheptadine hydrochloride generally refers to cyproheptadine hydrochloride sesquihydrate.


cerebellar ataxia

description: A neurological syndrome characterized by clumsy and uncoordinated movement of the limbs, trunk, and cranial muscles. It results from pathology in the cerebellum and its connections, or in the proprioceptive sensory pathways.


zidovudine

A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.


name: AIDS-related primary central nervous system lymphoma

description: A lymphoma (non-Hodgkin or Hodgkin) arising from the central nervous system and occurring in HIV-positive patients.


name: S22A1_HUMAN Solute carrier family 22 member 1 (sprot)

description: A solute carrier family 22 member 1 that is encoded in the genome of human.


name: NFKB1_HUMAN Nuclear factor NF-kappa-B p105 subunit (sprot)

description: A nuclear factor NF-kappa-B p105 subunit that is encoded in the genome of human.


diabetic kidney disease

description: Progressive kidney disorder caused by vascular damage to the glomerular capillaries, in patients with diabetes mellitus. It is usually manifested with nephritic syndrome and glomerulosclerosis.


METHYLENE BLUE ANHYDROUS

An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.


toxic encephalopathy

description: A group of neurologic disorders caused by damage to the nervous system following exposure to pharmacologic, biologic, and chemical agents. Examples of neurotoxins include chemotherapy agents, radiation treatment, heavy metals, pesticides, and food additives.


name: IF4A2_HUMAN Eukaryotic initiation factor 4A-II (sprot)

description: A eukaryotic initiation factor 4A-II that is encoded in the genome of human.


name: IF4G1_HUMAN Eukaryotic translation initiation factor 4 gamma 1 (sprot)

description: A eukaryotic translation initiation factor 4 gamma 1 that is encoded in the genome of human.


amoxicillin

A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.


dibutyl phthalate

A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of  butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.


TLR4_HUMAN Toll-like receptor 4 (sprot)

A Toll-like receptor 4 that is encoded in the genome of human.


childhood malignant neoplasm

description: A malignant tumor that occurs in children. Representative examples include soft tissue and bone sarcomas (e.g. osteosarcoma) and embryonal neoplasms (e.g. hepatoblastoma and rhabdoid tumor).


hemorrhoid

description: Dilated veins in the anal canal.


trabectedin

A tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer.


name: CSF1R_HUMAN Macrophage colony-stimulating factor 1 receptor (sprot)

description: A macrophage colony-stimulating factor 1 receptor that is encoded in the genome of human.


methadone

A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.


CP2B6_HUMAN Cytochrome P450 2B6 (sprot)

A cytochrome P450 2B6 that is encoded in the genome of human.


acidosis disorder

description: An abnormally high acidity of the blood and other body tissues. Acidosis can be either respiratory or metabolic.


IL6_HUMAN Interleukin-6 (sprot)

An interleukin-6 that is encoded in the genome of human.


heart failure

description: Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction.


name: GSK3B_HUMAN Glycogen synthase kinase-3 beta (sprot)

description: A glycogen synthase kinase-3 beta that is encoded in the genome of human.


name: ICAM1_HUMAN Intercellular adhesion molecule 1 (sprot)

description: An intercellular adhesion molecule 1 that is encoded in the genome of human.


epirubicin

An anthracycline that is the 4'-epi-isomer of doxorubicin.


name: ABTB2_HUMAN Ankyrin repeat and BTB/POZ domain-containing protein 2 (sprot)

description: An ankyrin repeat and BTB/POZ domain-containing protein 2 that is encoded in the genome of human.


name: MYOD1_HUMAN Myoblast determination protein 1 (sprot)

description: A myoblast determination protein 1 that is encoded in the genome of human.


name: TFE2_HUMAN Transcription factor E2-alpha (sprot)

description: A transcription factor E2-alpha that is encoded in the genome of human.


melatonin

A member of the class of  acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.


hyperglycemia

description: Abnormally high level of glucose in the blood.


ANXA3_HUMAN Annexin A3 (sprot)

An annexin A3 that is encoded in the genome of human.


puromycin

An aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome.


EF2_HUMAN Elongation factor 2 (sprot)

An elongation factor 2 that is encoded in the genome of human.


pemetrexed

An N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).


subacute cutaneous lupus erythematosus

description: Subacute cutaneous lupus erythematosus (SCLE) is a form of cutaneous lupus erythematosus (CLE) that can present either as a non-scarring, annular photo-distributed dermatosis or psoriasiform plaques. SCLE is associated with anti-Ro/SSA antibodies and can be drug-induced.


glycerol

A triol with a structure of propane substituted at positions 1, 2 and 3 by hydroxy groups.


HSP1_HUMAN Sperm protamine P1 (sprot)

A sperm protamine P1 that is encoded in the genome of human.


gilteritinib

A member of the class of pyrazines that is pyrazine-2-carboxamide which is substituted by {3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}nitrilo, (oxan-4-yl)nitrilo and ethyl groups at positions 3,5 and 6, respectively. It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively). Approved by the FDA for the treatment of acute myeloid leukemia in patients who have a FLT3 gene mutation.


non-small cell lung carcinoma

description: A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.


bleomycin

A glycopeptide produced by the bacterium Streptomyces verticillus. The term, 'bleomycin' refers to a family of structurally related compounds. When used as an anti-cancer agent, the chemotherapeutical forms are primarily bleomycin A2 and B2.


name: IFIH1_HUMAN Interferon-induced helicase C domain-containing protein 1 (sprot)

description: An interferon-induced helicase C domain-containing protein 1 that is encoded in the genome of human.


probucol

A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.


FOS_HUMAN Protein c-Fos (sprot)

A protein c-Fos that is encoded in the genome of human.


name: DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (sprot)

description: A DNA (cytosine-5)-methyltransferase 3A that is encoded in the genome of human.


name: EGFR_HUMAN Epidermal growth factor receptor (sprot)

description: An epidermal growth factor receptor that is encoded in the genome of human.


D-cycloserine

A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and  D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis).


diarrheal disease

description: The condition of having at least three loose or liquid bowel movements each day.


amphetamine

A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.


ITAM_HUMAN Integrin alpha-M (sprot)

An integrin alpha-M that is encoded in the genome of human.


name: FOSL1_HUMAN Fos-related antigen 1 (sprot)

description: A Fos-related antigen 1 that is encoded in the genome of human.


name: IBP3_HUMAN Insulin-like growth factor-binding protein 3 (sprot)

description: An insulin-like growth factor-binding protein 3 that is encoded in the genome of human.


name: CDN1A_HUMAN Cyclin-dependent kinase inhibitor 1 (sprot)

description: A cyclin-dependent kinase inhibitor 1 that is encoded in the genome of human.


MICAFUNGIN

A cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall. It is used as the sodium salt for the treatment of invasive candidiasis, and of aspergillosis in patients who are intolerant of other therapy.


name: acute myeloblastic leukemia with maturation

description: An acute myeloid leukemia (AML) characterized by blasts with evidence of maturation to more mature neutrophils. (WHO, 2001)


name: TNFA_HUMAN Tumor necrosis factor (sprot)

description: A tumor necrosis factor that is encoded in the genome of human.


name: CDC42_HUMAN Cell division control protein 42 homolog (sprot)

description: A cell division control protein 42 that is encoded in the genome of human.


coronary artery disorder

description: Narrowing of the coronary arteries due to fatty deposits inside the arterial walls. The diagnostic criteria may include documented history of any of the following: documented coronary artery stenosis greater than or equal to 50% (by cardiac catheterization or other modality of direct imaging of the coronary arteries); previous coronary artery bypass surgery (CABG); previous percutaneous coronary intervention (PCI); previous myocardial infarction. (ACC)


omega-3 fatty acid

A family of polyunsaturated fatty acids that have in common a final carbon-carbon double bond in the omega-3 position, i.e., the third bond from the methyl end of the fatty acid.


PERILLYL ALCOHOL

A perillyl alcohol in which the chiral centre has S configuration.


name: CDN1B_HUMAN Cyclin-dependent kinase inhibitor 1B (sprot)

description: A cyclin-dependent kinase inhibitor 1B that is encoded in the genome of human.


name: LGR5_HUMAN Leucine-rich repeat-containing G-protein coupled receptor 5 (sprot)

description: A leucine-rich repeat-containing G-protein coupled receptor 5 that is encoded in the genome of human.


puerarin

A hydroxyisoflavone that is  isoflavone substituted by hydroxy groups at positions 7 and 4' and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage.


name: KMT2B_HUMAN Histone-lysine N-methyltransferase 2B (sprot)

description: A histone-lysine N-methyltransferase 2B that is encoded in the genome of human.


chloramphenicol

An organochlorine compound that is dichloro-substituted acetamide containing a nitrobenzene ring, an amide bond and two alcohol functions.


hemolytic-uremic syndrome

description: Acute kidney injury associated with microangiopathic hemolytic anemia and thrombocytopenia.


ANISOMYCIN

An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.


spinal muscular atrophy

description: Spinal muscular atrophy (SMA) refers to a group of inherited conditions that affect the muscles. The severity of the condition; the associated signs and symptoms; and the age at which symptoms develop varies by subtype. In general, people with SMA experience progressive weakness and atrophy of muscles involved in mobility, the ability to sit unassisted, and head control. Breathing and swallowing may also be affected in severe cases. SMA is generally caused by changes (mutations) in the SMN1 gene and is inherited in an autosomal recessive manner. Extra copies of the SMN2 gene modify the severity of SMA. Rare autosomal dominant (caused by mutations in DYNC1H1, BICD2, or VAPB genes) and X-linked (caused by mutations in UBA1) forms of SMA exist. Treatment is based on the signs and symptoms present in each person.


CYCLIC ADENOSINE MONOPHOSPHATE

A 3',5'-cyclic purine nucleotide having having adenine as the nucleobase.


name: KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (sprot)

description: A ribosomal protein S6 kinase beta-1 that is encoded in the genome of human.


cisplatin

A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).


SRXN1_HUMAN Sulfiredoxin-1 (sprot)

A sulfiredoxin-1 that is encoded in the genome of human.


DEFB1_HUMAN Beta-defensin 1 (sprot)

A beta-defensin 1 that is encoded in the genome of human.


name: RAC1_HUMAN Ras-related C3 botulinum toxin substrate 1 (sprot)

description: A Ras-related C3 botulinum toxin substrate 1 that is encoded in the genome of human.


L-ascorbic acid

The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.


Hodgkins lymphoma

description: Hodgkin lymphoma (HL) is a heterogeneous group of malignant lymphoid neoplasms of B-cell origin characterized histologically by the presence of Hodgkin and Reed-Sternberg (HRS) cells in the vast majority of cases. There are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes.


fluconazole

A member of the class of  triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.


IL1A_HUMAN Interleukin-1 alpha (sprot)

An interleukin-1 alpha that is encoded in the genome of human.


NARINGENIN

The (S)-enantiomer of naringenin.


autism spectrum disorder

description: A spectrum of developmental disorders that includes autism, and Asperger syndrome. Signs and symptoms include poor communication skills, defective social interactions, and repetitive behaviors.


name: B3GN9_HUMAN UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 (sprot)

description: A UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 that is encoded in the genome of human.


name: KIF25_HUMAN Kinesin-like protein KIF25 (sprot)

description: A kinesin-like protein KIF25 that is encoded in the genome of human.


name: TPX2_HUMAN Targeting protein for Xklp2 (sprot)

description: A targeting protein for Xklp2 that is encoded in the genome of human.


aprepitant

A morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors.


name: TBCD9_HUMAN TBC1 domain family member 9 (sprot)

description: A TBC1 domain family member 9 that is encoded in the genome of human.


name: LPAR6_HUMAN Lysophosphatidic acid receptor 6 (sprot)

description: An oleoyl-L-alpha-lysophosphatidic acid receptor that is encoded in the genome of human.


name: GBP4_HUMAN Guanylate-binding protein 4 (sprot)

description: A guanylate-binding protein 4 that is encoded in the genome of human.


name: RUN3B_HUMAN RUN domain-containing protein 3B (sprot)

description: A RUN domain-containing protein 3B that is encoded in the genome of human.


IMIDAZOLE

An imidazole tautomer which has the migrating hydrogen at position 1.


name: RET4_HUMAN Retinol-binding protein 4 (sprot)

description: A retinol-binding protein 4 that is encoded in the genome of human.


AICA ribonucleotide

A 1-(phosphoribosyl)imidazolecarboxamide that is acadesine in which the hydroxy group at the 5' position has been converted to its monophosphate derivative.


SPB8_HUMAN Serpin B8 (sprot)

A serpin B8 that is encoded in the genome of human.


name: PSDE_HUMAN 26S proteasome non-ATPase regulatory subunit 14 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 14 that is encoded in the genome of human.


name: PRC1_HUMAN Protein regulator of cytokinesis 1 (sprot)

description: A protein regulator of cytokinesis 1 that is encoded in the genome of human.


ovarian hyperstimulation syndrome

description: A complication of ovulation induction in infertility treatment. It is graded by the severity of symptoms which include ovary enlargement, multiple ovarian follicles; ovarian cysts; ascites; and generalized edema. The full-blown syndrome may lead to renal failure, respiratory distress, and even death. Increased capillary permeability is caused by the vasoactive substances, such as vascular endothelial growth factors, secreted by the overly-stimulated ovaries.


cyclosporin A

A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.


Conjunctival hyperemia

description: Dilatation of the blood vessels of the conjunctiva leading to a red appearance of the sclera.


name: SL9A3_HUMAN Sodium/hydrogen exchanger 3 (sprot)

description: A sodium/hydrogen exchanger 3 that is encoded in the genome of human.


GUC2C_HUMAN Guanylyl cyclase C (sprot)

A guanylyl cyclase C that is encoded in the genome of human.


aspirin

A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.


Shock

description: The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury.


name: ACTHR_HUMAN Adrenocorticotropic hormone receptor (sprot)

description: An adrenocorticotropic hormone receptor that is encoded in the genome of human.


name: ODPX_HUMAN Pyruvate dehydrogenase protein X component, mitochondrial (sprot)

description: A pyruvate dehydrogenase protein X component, mitochondrial that is encoded in the genome of human.


name: MMP2_HUMAN 72 kDa type IV collagenase (sprot)

description: A 72 kDa type IV collagenase that is encoded in the genome of human.


name: SETD7_HUMAN Histone-lysine N-methyltransferase SETD7 (sprot)

description: A histone-lysine N-methyltransferase SETD7 that is encoded in the genome of human.


RUVB1_HUMAN RuvB-like 1 (sprot)

A RuvB-like 1 that is encoded in the genome of human.


TRY2_HUMAN Trypsin-2 (sprot)

A trypsin-2 that is encoded in the genome of human.


name: FUT3_HUMAN 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (sprot)

description: A 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 that is encoded in the genome of human.


HISPIDULIN

A monomethoxyflavone that is scutellarein methylated at position 6.


gastric cancer

description: A primary or metastatic malignant neoplasm involving the stomach.


name: KCNA5_HUMAN Potassium voltage-gated channel subfamily A member 5 (sprot)

description: A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of human.


name: F262_HUMAN 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (sprot)

description: A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 that is encoded in the genome of human.


atenolol

An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent.


ischemic colitis

description: Inflammation of the colon due to colonic ischemia resulting from alterations in systemic circulation or local vasculature.


deferoxamine

An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.


name: EGLN2_HUMAN Prolyl hydroxylase EGLN2 (sprot)

description: A prolyl hydroxylase EGLN2 that is encoded in the genome of human.


fibrotic liver disease

description: A liver disease characterized by the presence of excessive fibrous connective tissue in the liver.


cycloastragenol

A sapogenin that is the aglycone derivative of astragaloside IV, a major saponin extracted from the root of Astragalus membranaceus.


osteoporosis

description: A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).


name: IMA5_HUMAN Importin subunit alpha-5 (sprot)

description: An importin subunit alpha-5 that is encoded in the genome of human.


oxolinic acid

A quinolinemonocarboxylic acid having the carboxy group at position 7 as well as oxo and ethyl groups at positions 4 and 1 respectively and a dioxolo ring fused at the 5- and 6-positions. A synthetic antibiotic, it is used in veterinary medicine for the treatment of bacterial infections in cattle, pigs and poultry.


bacterial infectious disease

description: An acute infectious disorder that is caused by gram positive or gram negative bacteria; representative examples include pneumococcal, streptococcal, salmonella, and meningeal infections.


prasugrel

A racemate comprising equal amounts of (R)- and (S)-prasugrel. Used (as its hydrochloride salt) to prevent blood clots in people with acute coronary syndrome who are undergoing a procedure after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels.


myo-inositol

An inositol having myo- configuration.


glucose

An aldohexose used as a source of energy and metabolic intermediate.


name: VAMP2_HUMAN Vesicle-associated membrane protein 2 (sprot)

description: A vesicle-associated membrane protein 2 that is encoded in the genome of human.


abdominal obesity-metabolic syndrome

description: A combination of medical conditions that when present, increase the risk of heart attack, stroke, and diabetes mellitus. It includes the following medical conditions: increased blood pressure, central obesity, dyslipidemia, impaired glucose tolerance, and insulin resistance.


A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.


name: ETV7_HUMAN Transcription factor ETV7 (sprot)

description: A transcription factor ETV7 that is encoded in the genome of human.


acetate

A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid.


name: AL8A1_HUMAN 2-aminomuconic semialdehyde dehydrogenase (sprot)

description: A 2-aminomuconic semialdehyde dehydrogenase that is encoded in the genome of human.


name: TNF11_HUMAN Tumor necrosis factor ligand superfamily member 11 (sprot)

description: A tumor necrosis factor ligand superfamily member 11 that is encoded in the genome of human.


name: NF2L2_HUMAN Nuclear factor erythroid 2-related factor 2 (sprot)

description: A nuclear factor erythroid 2-related factor 2 that is encoded in the genome of human.


name: WASF2_HUMAN Actin-binding protein WASF2 (sprot)

description: An actin-binding protein WASF2 that is encoded in the genome of human.


name: CYFP1_HUMAN Cytoplasmic FMR1-interacting protein 1 (sprot)

description: A cytoplasmic FMR1-interacting protein 1 that is encoded in the genome of human.


topotecan

A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.


sensory peripheral neuropathy

description: Inflammation or degeneration of the sensory nerves.


name: TF2B_HUMAN Transcription initiation factor IIB (sprot)

description: A transcription initiation factor IIB that is encoded in the genome of human.


name: ELF5_HUMAN ETS-related transcription factor Elf-5 (sprot)

description: An ETS-related transcription factor Elf-5 that is encoded in the genome of human.


trichloroacetic acid

A monocarboxylic acid that is acetic acid in which all three methyl hydrogens are substituted by chlorine.


HIV infectious disease

description: An infection caused by the human immunodeficiency virus.


taurine

An amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid. It is a naturally occurring amino acid derived from  methionine and cysteine metabolism. An abundant component of fish- and meat-based foods, it has been used as an oral supplement in the treatment of disorders such as cystic fibrosis and hypertension.


psoriasis

description: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.


name: B2L13_HUMAN Bcl-2-like protein 13 (sprot)

description: A Bcl-2-like protein 13 that is encoded in the genome of human.


CASP3_HUMAN Caspase-3 (sprot)

A caspase-3 that is encoded in the genome of human.


traumatic brain injury

description: A brain disease that is characterized by brain dysfunction caused by an outside force, usually a violent blow to the head.


URSOLIC ACID

A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.


name: CDK6_HUMAN Cyclin-dependent kinase 6 (sprot)

description: A cyclin-dependent kinase 6 that is encoded in the genome of human.


dopamine

Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.


Cerebral atrophy

description: Atrophy (wasting, decrease in size of cells or tissue) affecting the cerebrum.


thymidine

A pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase.


A oxysterol that is cholesterol in which the hydrogen at the 4beta position has been replaced by a hydroxy group. A metabolite of cholesterol formed by the drug-metabolizing enzyme cytochrome P450 3A4, it is one of the major oxysterols in the human circulation.


name: ATP7B_HUMAN Copper-transporting ATPase 2 (sprot)

description: A copper-transporting ATPase 2 that is encoded in the genome of human.


name: Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1


amiodarone

A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a  cardiovascular drug used for the treatment of cardiac dysrhythmias.


name: TRPC3_HUMAN Short transient receptor potential channel 3 (sprot)

description: A short transient receptor potential cation channel TRPC3 that is encoded in the genome of human.


sorafenib

A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.


name: PTC2_HUMAN Protein patched homolog 2 (sprot)

description: A protein patched homolog 2 that is encoded in the genome of human.


anemia

description: A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability.


chlorpromazine

A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.


HMOX1_HUMAN Heme oxygenase 1 (sprot)

A heme oxygenase 1 that is encoded in the genome of human.


cardiac rhythm disease

description: Any variation from the normal rate or rhythm (which may include the origin of the impulse and/or its subsequent propagation) in the heart.


name: TLE1_HUMAN Transducin-like enhancer protein 1 (sprot)

description: A transducin-like enhancer protein 1 that is encoded in the genome of human.


INS_HUMAN Insulin (sprot)

An insulin gene translation product that is encoded in the genome of human.


name: QSOX1_HUMAN Sulfhydryl oxidase 1 (sprot)

description: A sulfhydryl oxidase 1 that is encoded in the genome of human.


name: EZH1_HUMAN Histone-lysine N-methyltransferase EZH1 (sprot)

description: A histone-lysine N-methyltransferase EZH1 that is encoded in the genome of human.


rifaximin

A semisynthetic member of the class of rifamycins and non-systemic gastrointestinal site-specific broad spectrum antibiotic. Used in the treatment of traveller's diarrhoea, hepatic encephalopathy and irritable bowel syndrome.


hepatitis

description: An active inflammatory process affecting the liver for more than six months. Causes include viral infections, autoimmune disorders, drugs, and metabolic disorders.


acute pancreatitis

description: An acute inflammatory process that leads to necrosis of the pancreatic parenchyma. Signs and symptoms include severe abdominal pain, nausea, vomiting, diarrhea, fever, and shock. Causes include alcohol consumption, presence of gallstones, trauma, and drugs.


andrographolide

A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.


Intestinal inflammation

description: A reaction characterizeds by capillary dilatation, leukocytic infiltration, redness, heat, pain, swelling localized to the in the intestinal tract.


retigabine

A substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An  anticonvulsant used to treat seizures associated with epilepsy in adults.


chronic renal failure syndrome

description: Impairment of the renal function due to chronic kidney damage.


neoplasm of thorax

description: A neoplasm (disease) that involves the thoracic segment of trunk.


thalidomide

A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.


Dysarthria

description: Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed.


spermine

A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.


name: CACP_HUMAN Carnitine O-acetyltransferase (sprot)

description: A carnitine O-acetyltransferase that is encoded in the genome of human.


L-histidine

The L-enantiomer of the amino acid histidine.


name: NR1H3_HUMAN Oxysterols receptor LXR-alpha (sprot)

description: An oxysterols receptor LXR-alpha that is encoded in the genome of human.


name: CTG1B_HUMAN Cancer/testis antigen 1 (sprot)

description: A cancer/testis antigen 1 that is encoded in the genome of human.


name: SMC5_HUMAN Structural maintenance of chromosomes protein 5 (sprot)

description: A structural maintenance of chromosomes protein 5 that is encoded in the genome of human.


forskolin

A labdane diterpenoid isolated from the Indian Coleus plant.


NMB_HUMAN Neuromedin-B (sprot)

A neuromedin-B that is encoded in the genome of human.


(-)-noradrenaline

The R-enantiomer of noradrenaline.


name: CCDC3_HUMAN Coiled-coil domain-containing protein 3 (sprot)

description: A coiled-coil domain-containing protein 3 that is encoded in the genome of human.


name: ATS9_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 9 (sprot)

description: An a disintegrin and metalloproteinase with thrombospondin motifs 9 that is encoded in the genome of human.


name: ERAP2_HUMAN Endoplasmic reticulum aminopeptidase 2 (sprot)

description: An endoplasmic reticulum aminopeptidase 2 that is encoded in the genome of human.


name: SGK1_HUMAN Serine/threonine-protein kinase Sgk1 (sprot)

description: A serine/threonine-protein kinase Sgk1 that is encoded in the genome of human.


PANX1_HUMAN Pannexin-1 (sprot)

A pannexin-1 that is encoded in the genome of human.


name: CEP55_HUMAN Centrosomal protein of 55 kDa (sprot)

description: A centrosomal protein of 55 kDa that is encoded in the genome of human.


name: CHK1_HUMAN Serine/threonine-protein kinase Chk1 (sprot)

description: A serine/threonine-protein kinase Chk1 that is encoded in the genome of human.


name: APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (sprot)

description: A DNA-(apurinic or apyrimidinic site) endonuclease that is encoded in the genome of human.


name: RAB5A_HUMAN Ras-related protein Rab-5A (sprot)

description: A Ras-related protein Rab-5A that is encoded in the genome of human.


name: DOCK1_HUMAN Dedicator of cytokinesis protein 1 (sprot)

description: A dedicator of cytokinesis protein 1 that is encoded in the genome of human.


name: MYO10_HUMAN Unconventional myosin-X (sprot)

description: A myosin-X that is encoded in the genome of human.


name: PR15A_HUMAN Protein phosphatase 1 regulatory subunit 15A (sprot)

description: A protein phosphatase 1 regulatory subunit 15A that is encoded in the genome of human.


name: PEG3_HUMAN Paternally-expressed gene 3 protein (sprot)

description: A paternally-expressed gene 3 protein that is encoded in the genome of human.


γ-butyrolactone

A  butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.


name: CDK7_HUMAN Cyclin-dependent kinase 7 (sprot)

description: A cyclin-dependent kinase 7 that is encoded in the genome of human.


alendronate

A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.


mirdametinib

A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position 2 by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer).


name: thyroid gland undifferentiated (anaplastic) carcinoma

description: A primary carcinoma of the thyroid gland composed of undifferentiated cells. The malignant cells demonstrate evidence of epithelial differentiation, either by immunohistochemistry or electron microscopic studies. Microscopically, in the majority of cases there is a mixture of spindle, epithelioid, and giant cells. The vast majority of the patients present with a rapidly enlarging neck mass. The clinical course is usually aggressive.


A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.


name: CDK4_HUMAN Cyclin-dependent kinase 4 (sprot)

description: A cell division protein kinase 4 that is encoded in the genome of human.


name: SETD2_HUMAN Histone-lysine N-methyltransferase SETD2 (sprot)

description: A histone-lysine N-methyltransferase SETD2 that is encoded in the genome of human.


name: PTK6_HUMAN Protein-tyrosine kinase 6 (sprot)

description: A protein-tyrosine kinase 6 that is encoded in the genome of human.


name: FOSL2_HUMAN Fos-related antigen 2 (sprot)

description: A Fos-related antigen 2 that is encoded in the genome of human.


name: MK01_HUMAN Mitogen-activated protein kinase 1 (sprot)

description: A mitogen-activated protein kinase 1 that is encoded in the genome of human.


CADH1_HUMAN Cadherin-1 (sprot)

A cadherin-1 that is encoded in the genome of human.


enoxolone

A pentacyclic triterpenoid that is olean-12-ene substituted by a hydroxy group at position 3, an oxo group at position 11 and a carboxy group at position 30.


diclofenac

A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.


name: CO1A1_HUMAN Collagen alpha-1(I) chain (sprot)

description: A collagen alpha-1(I) chain that is encoded in the genome of human.


digoxin

A  cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.


name: MRP2_HUMAN ATP-binding cassette sub-family C member 2 (sprot)

description: An ATP-binding cassette sub-family C member 2 that is encoded in the genome of human.


name: DUS6_HUMAN Dual specificity protein phosphatase 6 (sprot)

description: A dual specificity protein phosphatase 6 that is encoded in the genome of human.


panobinostat

A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its lactate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.


T-cell adult acute lymphocytic leukemia

description: An acute T-lymphoblastic leukemia occurring in adults.


name: LFTY1_HUMAN Left-right determination factor 1 (sprot)

description: A lefty 1 that is encoded in the genome of human.


name: SMAD2_HUMAN Mothers against decapentaplegic homolog 2 (sprot)

description: A smad2 that is encoded in the genome of human.


name: DPOD1_HUMAN DNA polymerase delta catalytic subunit (sprot)

description: A DNA polymerase delta catalytic subunit that is encoded in the genome of human.


name: ITPR1_HUMAN Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (sprot)

description: An inositol 1,4,5-trisphosphate receptor type 1 that is encoded in the genome of human.


MKLN1_HUMAN Muskelin (sprot)

A muskelin that is encoded in the genome of human.


name: CDK5_HUMAN Cyclin-dependent kinase 5 (sprot)

description: A cyclin-dependent kinase 5 that is encoded in the genome of human.


OLOMOUCINE

A 9H-purine that is substituted by a (2-hydroxyethyl)nitrilo, benzylnitrilo and a methyl group at positions 2,6 and 9, respectively. It is a  cyclin-dependent kinase inhibitor.


acute leukemia

description: A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).


lymphocytic colitis

description: Microscopic colitis characterized by the accumulation of lymphocytes in the colonic epithelium and lamina propria. Patients present with chronic watery diarrhea. Colonoscopy reveals normal colonic mucosa. The diagnosis is made with the microscopic examination of the colonic biopsy samples.


(R,R,S)-lobaplatin

The (R,R,S)-isomer of lobaplatin.


nasopharyngeal carcinoma

description: A carcinoma arising from the nasopharyngeal epithelium. It includes the following types: keratinizing squamous cell carcinoma, nonkeratinizing carcinoma (differentiated and undifferentiated), basaloid squamous cell carcinoma, and papillary adenocarcinoma.


name: PTEN_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (sprot)

description: A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN that is encoded in the genome of human.


name: TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (sprot)

description: A tyrosyl-DNA phosphodiesterase 1 that is encoded in the genome of human.


name: TADBP_HUMAN TAR DNA-binding protein 43 (sprot)

description: A TAR DNA-binding protein 43 that is encoded in the genome of human.


name: FGFR2_HUMAN Fibroblast growth factor receptor 2 (sprot)

description: A fibroblast growth factor receptor 2 that is encoded in the genome of human.


metformin

A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.


acute kidney failure

description: Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria.


name: NCOA1_HUMAN Nuclear receptor coactivator 1 (sprot)

description: A nuclear receptor coactivator 1 that is encoded in the genome of human.


MBP_HUMAN Myelin basic protein (sprot)

A myelin basic protein that is encoded in the genome of human.


name: NFIB_HUMAN Nuclear factor 1 B-type (sprot)

description: A nuclear factor 1 B-type that is encoded in the genome of human.


name: AGTR1_HUMAN Type-1 angiotensin II receptor (sprot)

description: An angiotensin II receptor 1 that is encoded in the genome of human.


flufenamic acid

An aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. An analgesic and anti-inflammatory, it is used in rheumatic disorders.


name: YAP1_HUMAN Transcriptional coactivator YAP1 (sprot)

description: A transcriptional coactivator YAP1 that is encoded in the genome of human.


CHLOROBENZENE

The simplest member of the class of monochlorobenzenes, that is benzene in which a single hydrogen has been substituted by a chlorine.


IL8_HUMAN Interleukin-8 (sprot)

An interleukin-8 that is encoded in the genome of human.


nebivolol

A member of the class of chromanes that is 2,2'-iminodiethanol in which one hydrogen attached to each hydroxy-bearing carbon is replaced by a  6-fluorochroman-2-yl group.


name: IGF1R_HUMAN Insulin-like growth factor 1 receptor (sprot)

description: An insulin-like growth factor 1 receptor that is encoded in the genome of human.


pyrimethamine

An aminopyrimidine that is pyrimidine-2,4-diamine which is substituted at position 5 by a p-chlorophenyl group and at position 6 by an ethyl group. It is a folic acid antagonist used as an antimalarial or with a sulfonamide to treat toxoplasmosis.


fingolimod

An aminodiol that consists of propane-1,3-diol having amino and 2-(4-octylphenyl)ethyl substituents at the 2-position. It is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. A prodrug, fingolimod is phosphorylated by sphingosine kinase to active metabolite fingolimod-phosphate, a structural analogue of sphingosine 1-phosphate.


dexamethasone

A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of  glucocorticoids.


name: GBRL1_HUMAN Gamma-aminobutyric acid receptor-associated protein-like 1 (sprot)

description: A gamma-aminobutyric acid receptor-associated protein-like 1 that is encoded in the genome of human.


malaria

description: Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. Infection with malaria parasites may result in a wide variety of symptoms, ranging from absent or very mild symptoms to severe disease and even death. People who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. In general, malaria is a curable disease if diagnosed and treated promptly and correctly.Treatment depends on many factors including disease severity, the species of malaria parasite causing the infection and the part of the world in which the infection was acquired.


name: DNM1L_HUMAN Dynamin-1-like protein (sprot)

description: A dynamin-1-like protein that is encoded in the genome of human.


iodine

Molecule comprising two covalently bonded iodine atoms with overall zero charge..


glucose

D-Glucopyranose with beta configuration at the anomeric centre.


name: MK03_HUMAN Mitogen-activated protein kinase 3 (sprot)

description: A mitogen-activated protein kinase 3 that is encoded in the genome of human.


name: PD1L1_HUMAN Programmed cell death 1 ligand 1 (sprot)

description: A programmed cell death 1 ligand 1 that is encoded in the genome of human.


name: CD8A_HUMAN T-cell surface glycoprotein CD8 alpha chain (sprot)

description: A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of human.


name: ING4_HUMAN Inhibitor of growth protein 4 (sprot)

description: An inhibitor of growth protein 4 that is encoded in the genome of human.


PICEATANNOL

A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.


name: GSH1_HUMAN Glutamate--cysteine ligase catalytic subunit (sprot)

description: A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of human.


artesunate

An artemisinin derivative that is the hemisuccinate ester of the lactol resulting from the reduction of the lactone carbonyl group of artemisinin. It is used, generally as the sodium salt, for the treatment of malaria.


CD68_HUMAN Macrosialin (sprot)

A macrosialin that is encoded in the genome of human.


name: AIF1_HUMAN Allograft inflammatory factor 1 (sprot)

description: An allograft inflammatory factor 1 that is encoded in the genome of human.


name: FOXP2_HUMAN Forkhead box protein P2 (sprot)

description: A forkhead box protein P2 that is encoded in the genome of human.


sudden sensorineural hearing loss

description: Sensorineural hearing loss which develops suddenly over a period of hours or a few days. It varies in severity from mild to total deafness. Sudden deafness can be due to head trauma, vascular diseases, infections, or can appear without obvious cause or warning.


CAMPTOTHECIN

A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).


name: ABCG2_HUMAN Broad substrate specificity ATP-binding cassette transporter ABCG2 (sprot)

description: A broad substrate specificity ATP-binding cassette transporter ABCG2 that is encoded in the genome of human.


naloxone

A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.


name: ZGLP1_HUMAN GATA-type zinc finger protein 1 (sprot)

description: A GATA-type zinc finger protein 1 that is encoded in the genome of human.


γ-linolenic acid

A C18, omega-6 acid fatty acid comprising a linolenic acid having cis- double bonds at positions 6, 9 and 12.


name: PCNA_HUMAN Proliferating cell nuclear antigen (sprot)

description: A proliferating cell nuclear antigen that is encoded in the genome of human.


finasteride

An aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia.


name: TINAL_HUMAN Tubulointerstitial nephritis antigen-like (sprot)

description: A tubulointerstitial nephritis antigen-like that is encoded in the genome of human.


clonidine

A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.


depressive disorder

description: A melancholy feeling of sadness and despair.


A phosphate ion that is the conjugate base of hydrogenphosphate.


malignant pancreatic neoplasm

description: A malignant neoplasm involving the pancreas.


linagliptin

A xanthine that is 7H-xanthine bearing (4-methylquinazolin-2-yl)methyl, methyl, but-2-yn-1-yl and 3-aminopiperidin-1-yl substituents at positions 1, 3, 7 and 8 respectively (the R-enantiomer). Used for treatment of type II diabetes.


name: SRBP1_HUMAN Sterol regulatory element-binding protein 1 (sprot)

description: A sterol regulatory element-binding protein 1 that is encoded in the genome of human.


hydrogen peroxide

An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.


name: BMP7_HUMAN Bone morphogenetic protein 7 (sprot)

description: A bone morphogenetic protein 7 that is encoded in the genome of human.


name: YBOX1_HUMAN Y-box-binding protein 1 (sprot)

description: A Y-box-binding protein 1 that is encoded in the genome of human.


isopropanol

A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group.


actinic keratosis

description: A precancerous lesion of the skin composed of atypical keratinocytes. It is characterized by the presence of thick, scaly patches of skin. Several histologic variants have been described, including atrophic, acantholytic, and hyperkeratotic variants.


vascular disorder

description: A general term used to describe any disease affecting blood vessels]. It includes vascular abnormalities caused by degenerative, metabolic and inflammatory conditions, embolic diseases, coagulative disorders, and functional disorders such as posteri or reversible encephalopathy syndrome.


name: DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (sprot)

description: A discoidin domain-containing receptor 1 that is encoded in the genome of human.


name: FAK2_HUMAN Protein-tyrosine kinase 2-beta (sprot)

description: A focal adhesion kinase 2 that is encoded in the genome of human.


lenalidomide

A dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-alpha.


multicentric Castleman disease

description: Multicentric castleman disease (MCD) is an aggressive form of Castleman disease that mostly results from human herpesvirus 8 (HHV8) infection. It manifests by fever, diffuse lymphadenopathy, hepatosplenomegaly, Involvement of the respiratory system and increased C-reactive protein.


MYXOTHIAZOL

A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S,3E,5E)-7-methylocta-3,5-dien-2-yl group. It is an inhibitor of coenzyme Q - cytochrome c reductase.


name: JUNB_HUMAN Transcription factor JunB (sprot)

description: A transcription factor JunB that is encoded in the genome of human.


name: AT2B2_HUMAN Plasma membrane calcium-transporting ATPase 2 (sprot)

description: A plasma membrane calcium-transporting ATPase 2 that is encoded in the genome of human.


bivalirudin

A synthetic peptide of 20 amino acids, comprising D-Phe, Pro, Arg, Pro, Gly, Gly, Gly, Gly, Asn, Gly, Asp, Phe, Glu, Glu, Ile, Pro, Glu, Glu, Tyr, and Leu in sequence. A congener of hirudin (a naturally occurring drug found in the saliva of the medicinal leech), it a specific and reversible inhibitor of thrombin, and is used as an anticoagulant.


hyperbilirubinemia

description: A disease characterized by elevated level of the pigment bilirubin in the blood.


levodopa

An optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease


methylglyoxal

A 2-oxo aldehyde derived from propanal.


type 1 diabetes mellitus

description: A chronic condition characterized by minimal or absent production of insulin by the pancreas.


UTRN_HUMAN Utrophin (sprot)

A utrophin that is encoded in the genome of human.


name: DLP1_HUMAN All trans-polyprenyl-diphosphate synthase PDSS2 (sprot)

description: An all trans-polyprenyl-diphosphate synthase PDSS2 that is encoded in the genome of human.


name: MYC_HUMAN Myc proto-oncogene protein (sprot)

description: A c-myc protein that is encoded in the genome of human.


name: HIF1A_HUMAN Hypoxia-inducible factor 1-alpha (sprot)

description: A hypoxia-inducible factor 1-alpha that is encoded in the genome of human.


PRDX1_HUMAN Peroxiredoxin-1 (sprot)

A peroxiredoxin-1 that is encoded in the genome of human.


name: M10L1_HUMAN RNA helicase Mov10l1 (sprot)

description: An RNA helicase Mov10l1 that is encoded in the genome of human.


hypertensive disorder

description: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.


name: RFOX3_HUMAN RNA binding protein fox-1 homolog 3 (sprot)

description: An RNA binding protein fox-1 homolog 3 that is encoded in the genome of human.


name: SNAI1_HUMAN Zinc finger protein SNAI1 (sprot)

description: A zinc finger protein SNAI1 that is encoded in the genome of human.


GARS_HUMAN Glycine--tRNA ligase (sprot)

A glycine--tRNA ligase that is encoded in the genome of human.


name: S12A9_HUMAN Solute carrier family 12 member 9 (sprot)

description: A solute carrier family 12 member 9 that is encoded in the genome of human.


tofacitinib

A pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis.


ANGT_HUMAN Angiotensinogen (sprot)

An angiotensinogen that is encoded in the genome of human.


name: ACK1_HUMAN Activated CDC42 kinase 1 (sprot)

description: An activated CDC42 kinase 1 that is encoded in the genome of human.


name: WEE1_HUMAN Wee1-like protein kinase (sprot)

description: A Wee1-like protein kinase that is encoded in the genome of human.


nimesulide

An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.


chronic kidney disease

description: Impairment of the renal function secondary to chronic kidney damage persisting for three or more months.


penicillin G

Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6.


name: SCYL1_HUMAN N-terminal kinase-like protein (sprot)

description: An N-terminal kinase-like protein that is encoded in the genome of human.


ROTENONE

A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).


name: HXB8_HUMAN Homeobox protein Hox-B8 (sprot)

description: A homeobox protein Hox-B8 that is encoded in the genome of human.


abacavir

A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection.


Hypercholesterolemia

description: An increased concentration of cholesterol in the blood.


losartan

A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position


name: KPCA_HUMAN Protein kinase C alpha type (sprot)

description: A protein kinase C alpha type that is encoded in the genome of human.


acrylamide

A member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia.


undifferentiated (embryonal) sarcoma

description: An aggressive malignant mesenchymal neoplasm that arises from the liver and usually occurs in older children. It is composed of immature spindle, stellate, polymorphous, and giant cells.


progesterone

A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.


name: CCL14_HUMAN C-C motif chemokine 14 (sprot)

description: A C-C motif chemokine 14 that is encoded in the genome of human.


carfilzomib

A synthetic tetrapeptide consisting of morpholin-4-acetyl, L-2-amino-4-phenylbutanoyl, L-leucyl and L-phenylalanyl residues joined in sequence with the C-terminus connected to the amino group of (2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-1-one via an amide linkage. Used for the treatment of patients with multiple myeloma


name: NFAC1_HUMAN Nuclear factor of activated T-cells, cytoplasmic 1 (sprot)

description: A nuclear factor of activated T-cells, cytoplasmic 1 that is encoded in the genome of human.


L-arginine

An L-alpha-amino acid that is the L-isomer of arginine.


name: ACM3_HUMAN Muscarinic acetylcholine receptor M3 (sprot)

description: A muscarinic acetylcholine receptor M3 that is encoded in the genome of human.


Erythema

description: Redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin.


caffeine

A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.


GCH1_HUMAN GTP cyclohydrolase 1 (sprot)

A GTP cyclohydrolase 1 that is encoded in the genome of human.


arecoline

A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.


glaucoma

description: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.


name: ARP5_HUMAN Actin-related protein 5 (sprot)

description: An actin-related protein 5 that is encoded in the genome of human.


cadmium dichloride

A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.


name: SDF1_HUMAN Stromal cell-derived factor 1 (sprot)

description: A stromal cell-derived factor 1 that is encoded in the genome of human.


name: ZEP3_HUMAN Transcription factor HIVEP3 (sprot)

description: A transcription factor HIVEP3 that is encoded in the genome of human.


name: NRG3_HUMAN Pro-neuregulin-3, membrane-bound isoform (sprot)

description: A pro-neuregulin-3, membrane-bound isoform that is encoded in the genome of human.


RAI14_HUMAN Ankycorbin (sprot)

An ankycorbin that is encoded in the genome of human.


name: TIMP1_HUMAN Metalloproteinase inhibitor 1 (sprot)

description: A metalloproteinase inhibitor 1 that is encoded in the genome of human.


zoledronic acid

An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.


tuberous sclerosis

description: Hereditary disease characterized by seizures, mental retardation, developmental delay, and skin and ocular lesions. First signs usually occur during infancy or childhood but in rare cases may not occur until 2nd or 3rd decade.


hormone receptor-positive breast cancer

description: A breast carcinoma which is positive for expression of estrogen receptor (ER), progesterone receptor (PR), and is negative for expression of human epidermal growth factor receptor 2 (HER2).


autoimmune disease

description: A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis).


name: SP1_HUMAN Transcription factor Sp1 (sprot)

description: A transcription factor Sp1 that is encoded in the genome of human.


dilated cardiomyopathy

description: Cardiomyopathy which is characterized by dilation and contractile dysfunction of the left and right ventricles. It may be idiopathic, or it may result from a myocardial infarction, myocardial infection, or alcohol abuse. It is a cause of congestive heart failure.


lung cancer

description: A malignant neoplasm involving the lung.


CARNOSIC ACID

An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from rosemary (Rosmarinus officinalis) and common sage (Salvia officinalis) and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity.


peritonitis

description: Inflammation of the peritoneum due to infection by bacteria or fungi. Causes include liver disease, perforation of the gastrointestinal tract or biliary tract, and peritoneal dialysis. Patients usually present with abdominal pain and tenderness, fever, chills, and nausea and vomiting. It is an emergency medical condition that requires prompt medical attention and treatment.


name: RM13_HUMAN Large ribosomal subunit protein uL13m (sprot)

description: A large ribosomal subunit protein uL13m that is encoded in the genome of human.


name: TEAD1_HUMAN Transcriptional enhancer factor TEF-1 (sprot)

description: A transcriptional enhancer factor TEF-1 that is encoded in the genome of human.


senile cataract

description: A cataract with no obvious cause occurring in persons over 50 years old.


name: RLBP1_HUMAN Retinaldehyde-binding protein 1 (sprot)

description: A retinaldehyde-binding protein 1 that is encoded in the genome of human.


BECN1_HUMAN Beclin-1 (sprot)

A beclin-1 that is encoded in the genome of human.


APEL_HUMAN Apelin (sprot)

An apelin that is encoded in the genome of human.


cocaine

A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.


name: S6A11_HUMAN Sodium- and chloride-dependent GABA transporter 3 (sprot)

description: A sodium- and chloride-dependent GABA transporter 3 that is encoded in the genome of human.


scoliosis

description: A congenital or acquired spinal deformity characterized by lateral curvature of the spine.


lymphatic system disorder

description: A disease involving the lymphatic part of lymphoid system.


LEG9_HUMAN Galectin-9 (sprot)

A galectin-9 that is encoded in the genome of human.


IL18_HUMAN Interleukin-18 (sprot)

An interleukin-18 that is encoded in the genome of human.


IL17_HUMAN Interleukin-17A (sprot)

An interleukin-17A that is encoded in the genome of human.


terretonin

A tetracyclic meroterpenoid that is isolated from Aspergillus terreus.


name: GSH0_HUMAN Glutamate--cysteine ligase regulatory subunit (sprot)

description: A glutamate--cysteine ligase regulatory subunit that is encoded in the genome of human.


sitagliptin

A  triazolopyrazine that exhibits  hypoglycemic activity.


chronic asthma

description: An asthma that is characterized by the development of persistent airway inflammation and recurrent attacks of breathlessness and wheezing, which vary in severity and frequency.


nicotine

A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.


systolic heart failure

description: Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying.


dinoprostone

Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.


name: PGK2_HUMAN Phosphoglycerate kinase 2 (sprot)

description: A phosphoglycerate kinase 2 that is encoded in the genome of human.


NANO2_HUMAN Nanos homolog 2 (sprot)

A nanos homolog 2 that is encoded in the genome of human.


name: TE2IP_HUMAN Telomeric repeat-binding factor 2-interacting protein 1 (sprot)

description: A telomeric repeat-binding factor 2-interacting protein 1 that is encoded in the genome of human.


ceftriaxone

A third-generation cephalosporin compound having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups.


name: drug-induced autoimmune hemolytic anemia

description: Drug-induced autoimmune hemolytic anemia is a type of autoimmune hemolytic anemia (AIHA) that occurs as a reaction to therapeutic drugs, and can be due to various mechanisms.


Recurrent hypoglycemia

description: Recurrent episodes of decreased concentration of glucose in the blood.


palmitic acid

A straight-chain, sixteen-carbon, saturated long-chain fatty acid.


name: KLF7_HUMAN Krueppel-like factor 7 (sprot)

description: A krueppel-like factor 7 that is encoded in the genome of human.


myelofibrosis

description: A partial or complete replacement of the bone marrow stroma by fibrous tissue. It can be a primary bone marrow lesion as part of the chronic myeloproliferative disorders (chronic idiopathic myelofibrosis), a manifestation of acute myeloid leukemia (acute panmyelosis with myelofibrosis), or a secondary phenomenon due to bone marrow involvement by a metastatic tumor (e.g., metastatic breast carcinoma). --2003


bumetanide

A member of the class of benzoic acids that is 4-phenoxybenzoic acid in which the hydrogens ortho to the phenoxy group are substituted by butylamino and sulfamoyl groups. Bumetanide is a diuretic, and is used for treatment of oedema associated with congestive heart failure, hepatic and renal disease.


DMD_HUMAN Dystrophin (sprot)

A dystrophin that is encoded in the genome of human.


rhabdomyosarcoma

description: A rare aggressive malignant mesenchymal neoplasm arising from skeletal muscle. It usually occurs in children and young adults. Only a small percentage of tumors arise in the skeletal muscle of the extremities. The majority arise in other anatomical sites.


cholangitis

description: An acute or chronic inflammatory process affecting the biliary tract.


pyruvate

A 2-oxo monocarboxylic acid anion that is the conjugate base of pyruvic acid, arising from deprotonation of the carboxy group.


name: PGH2_HUMAN Prostaglandin G/H synthase 2 (sprot)

description: A prostaglandin G/H synthase 2 that is encoded in the genome of human.


diethyl ether

An ether in which the oxygen atom is linked to two ethyl groups.


pneumonia

description: An acute, acute and chronic, or chronic inflammation focally or diffusely affecting the lung parenchyma, caused by an infection in one or both of the lungs (by bacteria, viruses, fungi, or mycoplasma.). Symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness.


teicoplanin

A complex mixture of related natural products isolated from the fermentation broth of a strain of Actinoplanes teichomyceticus comprising five major components (teicoplanin A2-1 through A2-5), a hydrolysis component (teicoplanin A3-1), and four minor components (teicoplanin RS-1 through RS-4). An antibiotic with a similar spectrum of activity to vancomycin, it is used to treat serious Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus and Enterococcus faecalis.


cerebrovascular disorder

description: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.


canagliflozin

A C-glycosyl compound that is used (in its hemihydrate form) for treatment of type II diabetes via inhibition of sodium-glucose transport protein subtype 2.


hyperlipidemia

description: Elevated levels of lipids in the blood.


name: GATA1_HUMAN Erythroid transcription factor (sprot)

description: An erythroid transcription factor that is encoded in the genome of human.


name: KS6A5_HUMAN Ribosomal protein S6 kinase alpha-5 (sprot)

description: A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of human.


name: GRHL3_HUMAN Grainyhead-like protein 3 homolog (sprot)

description: A grainyhead-like protein 3 that is encoded in the genome of human.


name: IRF6_HUMAN Interferon regulatory factor 6 (sprot)

description: An interferon regulatory factor 6 that is encoded in the genome of human.


name: RAB9A_HUMAN Ras-related protein Rab-9A (sprot)

description: A Ras-related protein Rab-9A that is encoded in the genome of human.


name: RAB23_HUMAN Ras-related protein Rab-23 (sprot)

description: A Ras-related protein Rab-23 that is encoded in the genome of human.


name: CRIS2_HUMAN Cysteine-rich secretory protein 2 (sprot)

description: A cysteine-rich secretory protein 2 that is encoded in the genome of human.


PLMN_HUMAN Plasminogen (sprot)

A plasminogen that is encoded in the genome of human.


calcium oxalate

The calcium salt of oxalic acid, which in excess in the urine may lead to formation of oxalate calculi (kidney stones).


name: GLI2_HUMAN Zinc finger protein GLI2 (sprot)

description: A zinc finger protein GLI2 that is encoded in the genome of human.


somatostatin

A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14.


name: RAMP1_HUMAN Receptor activity-modifying protein 1 (sprot)

description: A receptor activity-modifying protein 1 that is encoded in the genome of human.


description: A disorder characterized by a marked pattern of inattention and/or hyperactivity-impulsivity that is inconsistent with developmental level and clearly interferes with functioning in at least two settings (e.g. at home and at school). When present, the symptoms of hyperactivity are most often present before the age of 7 years. There are three recognized presentations or subtypes from most to least common: combined type, inattentive/distractible type, hyperactive/impulsive type.


name: C1D_HUMAN Nuclear nucleic acid-binding protein C1D (sprot)

description: A nuclear nucleic acid-binding protein C1D that is encoded in the genome of human.


name: CCL22_HUMAN C-C motif chemokine 22 (sprot)

description: A C-C motif chemokine 22 that is encoded in the genome of human.


name: RAD21_HUMAN Double-strand-break repair protein rad21 homolog (sprot)

description: A double-strand-break repair protein rad21 homolog that is encoded in the genome of human.


name: NEIL1_HUMAN Endonuclease 8-like 1 (sprot)

description: An endonuclease 8-like 1 that is encoded in the genome of human.


osteoarthritis

description: A noninflammatory degenerative joint disease occurring chiefly in older persons, characterized by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.


diacylglycerol (18:0/18:1/0:0)

A 1,2-diglyceride in which the fatty acyl groups at positions 1 and 2 are specified as C18:0 and C18:1 respectively.


name: SOS1_HUMAN Son of sevenless homolog 1 (sprot)

description: A son of sevenless homolog 1 that is encoded in the genome of human.


lip and oral cavity carcinoma

description: A carcinoma arising in the lip or oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma. Lip carcinomas are usually basal cell or squamous cell carcinomas.


raloxifene

A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.


name: KCJ12_HUMAN ATP-sensitive inward rectifier potassium channel 12 (sprot)

description: An ATP-sensitive inward rectifier potassium channel 12 that is encoded in the genome of human.


An aromatic ketone that is propiophenone in which the hydrogen alpha- to the keto group has been replaced by a methylamino group.


Hypothermia

description: Reduced body temperature due to failed thermoregulation.


name: RUNX2_HUMAN Runt-related transcription factor 2 (sprot)

description: A runt-related transcription factor 2 that is encoded in the genome of human.


name: CSF1_HUMAN Macrophage colony-stimulating factor 1 (sprot)

description: A macrophage colony-stimulating factor 1 that is encoded in the genome of human.


ITAV_HUMAN Integrin alpha-V (sprot)

An integrin alpha-V that is encoded in the genome of human.


name: APAF_HUMAN Apoptotic protease-activating factor 1 (sprot)

description: An apoptotic protease-activating factor 1 that is encoded in the genome of human.


name: RMD1_HUMAN Regulator of microtubule dynamics protein 1 (sprot)

description: A regulator of microtubule dynamics protein 1 that is encoded in the genome of human.


decabromodiphenyl ether

A polybromodiphenyl ether that is diphenyl ether in which all of the hydrogens have been replaced by bromines.


name: ZEB1_HUMAN Zinc finger E-box-binding homeobox 1 (sprot)

description: A zinc finger E-box-binding homeobox 1 that is encoded in the genome of human.


name: ATOH1_HUMAN Transcription factor ATOH1 (sprot)

description: A transcription factor ATOH1 that is encoded in the genome of human.


glioma

description: A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas.


name: RNAS1_HUMAN Ribonuclease pancreatic (sprot)

description: A ribonuclease pancreatic that is encoded in the genome of human.


name: VASH1_HUMAN Tubulinyl-Tyr carboxypeptidase 1 (sprot)

description: A tubulinyl-Tyr carboxypeptidase 1 that is encoded in the genome of human.


aciclovir

An oxopurine that is  guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.


acute respiratory distress syndrome

description: Progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. Cases of neonatal respiratory distress syndrome are not included in this definition.


trifluoperazine

A member of the class of phenothiazines that is  phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.


name: ASM_HUMAN Sphingomyelin phosphodiesterase (sprot)

description: A sphingomyelin phosphodiesterase that is encoded in the genome of human.


rosuvastatin

A dihydroxy monocarboxylic acid that is (6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl} hept-6-enoic acid carrying two hydroxy substituents at positions 3 and 5 (the 3R,5S-diastereomer).


name: TCHP_HUMAN Trichoplein keratin filament-binding protein (sprot)

description: A trichoplein keratin filament-binding protein that is encoded in the genome of human.


ademetionine

A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.


name: SCD_HUMAN Stearoyl-CoA desaturase (sprot)

description: A stearoyl-CoA desaturase that is encoded in the genome of human.


allergic contact dermatitis

description: An inflammatory skin condition caused by an immune response to direct contact between the skin and an allergen. It consists of a delayed type of allergic reaction at the affected site with resulting red, swollen, and blistered skin that may itch or leak.


prednisone

A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.


ulcerative colitis

description: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.


resveratrol

A resveratrol in which the double bond has E configuration.


Abnormal left ventricular function

description: Inability of the left ventricle to perform its normal physiologic function. Failure is either due to an inability to contract the left ventricle or the inability to relax completely and fill with blood during diastole.


capecitabine

A carbamate ester that is cytidine in which the hydrogen at position 5 is replaced by fluorine and in which the amino group attached to position 4 is converted into its N-(penyloxy)carbonyl derivative. Capecitabine is a antineoplastic agent used in the treatment of cancers.


sulfasalazine

An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.


Myalgia

description: Pain in muscle.


CD40L_HUMAN CD40 ligand (sprot)

A tumor necrosis factor ligand superfamily member 5 that is encoded in the genome of human.


S100B_HUMAN Protein S100-B (sprot)

A protein S100-B that is encoded in the genome of human.


daunorubicin

A natural product found in Actinomadura roseola.


description: Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) or clonal (malignant) proliferation of lymphoid cells that develops as a consequence of immunosuppression in a recipient of a solid organ or bone marrow allograft. PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven polyclonal lymphoid proliferations to EBV-positive or EBV- negative lymphomas of predominantly B-cell or less often T-cell type. (WHO, 2001)


IL7_HUMAN Interleukin-7 (sprot)

An interleukin-7 that is encoded in the genome of human.


urinary bladder neoplasm

description: A benign or malignant, primary or metastatic neoplasm of the bladder. - 2003


adenosine

A ribonucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a beta-N(9)-glycosidic bond.


CADH2_HUMAN Cadherin-2 (sprot)

A cadherin-2 that is encoded in the genome of human.


postmenopausal osteoporosis

description: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.


enzalutamide

A benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with methylamine. Used for the treatment of of metastatic castration-resistant prostate cancer.


name: AGRL4_HUMAN Adhesion G protein-coupled receptor L4 (sprot)

description: An adhesion G protein-coupled receptor L4 that is encoded in the genome of human.


salmonellosis

description: Infections with bacteria of the genus salmonella.


COF1_HUMAN Cofilin-1 (sprot)

A cofilin-1 that is encoded in the genome of human.


name: GBA2_HUMAN Non-lysosomal glucosylceramidase (sprot)

description: A non-lysosomal glucosylceramidase that is encoded in the genome of human.


RELL1_HUMAN RELT-like protein 1 (sprot)

A RELT-like protein 1 that is encoded in the genome of human.


alectinib

An organic heterotetracyclic compound that is 6,6-dimethyl-5,6-dihydro-11H-benzo[b]carbazol-11-one carrying additional cyano, 4-(morpholin-4-yl)piperidin-1-yl and ethyl substituents at positions 3, 8 and 9 respectively. Used (as the hydrochloride salt) for the treatment of patients with anaplastic lymphoma kinase-positive, metastatic non-small cell lung cancer.


name: CCDC6_HUMAN Coiled-coil domain-containing protein 6 (sprot)

description: A coiled-coil domain-containing protein 6 that is encoded in the genome of human.


name: AGRE1_HUMAN Adhesion G protein-coupled receptor E1 (sprot)

description: An adhesion G protein-coupled receptor E1 that is encoded in the genome of human.


fatty liver disease

description: A reversible condition wherein large vacuoles of triglyceride fat accumulate in liver cells via the process of steatosis.


MFGM_HUMAN Lactadherin (sprot)

A lactadherin that is encoded in the genome of human.


cholangiocarcinoma

description: A carcinoma that arises from the intrahepatic biliary tree (intrahepatic cholangiocarcinoma) or from the junction, or adjacent to the junction, of the right and left hepatic ducts (hilar cholangiocarcinoma). Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor.


NIGRANOIC ACID

A tetracyclic triterpenoid that is 3,4-secocycloarta-4(28),24-(Z)-diene substituted by carboxy groups at positions 3 and 26. Isolated from Schisandra henryi and Schisandra propinqua, it exhibits cytotoxic and anti-HIV activities.


name: ASCL4_HUMAN Achaete-scute homolog 4 (sprot)

description: An achaete-scute homolog 4 that is encoded in the genome of human.


nitrocellulose

A (1->4)-beta-D-glucan compound formed by nitrating cellulose through exposure to nitric acid or another powerful nitrating agent.