name: Refractory Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

description: Diffuse large B-cell lymphoma that resulted from the transformation of indolent B-cell non-Hodgkin lymphoma and is resistant to treatment.


name: Refractory Monomorphic Epitheliotropic Intestinal T-cell Lymphoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Monomorphic epitheliotropic intestinal T-cell lymphoma that is resistant to treatment.


name: Adult Grade III Lymphomatoid Granulomatosis

description: Grade III lymphomatoid granulomatosis that occurs in adulthood.


Cyclin D1-Negative Mantle Cell Lymphoma

description: A molecular subtype of mantle cell lymphoma characterized by the absence of cyclin D1 expression and CCND1 rearrangement.


name: Recurrent Aggressive B-Cell Non-Hodgkin Lymphoma

description: The reemergence of an aggressive B-cell non-Hodgkin lymphoma after a period of remission.


Peritoneal Primary Effusion Lymphoma

description: Primary effusion lymphoma that affects the peritoneal cavity. The majority of patients are HIV-positive men.


name: T-Cell Non-Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for T-cell non-Hodgkin lymphoma based on the Ann Arbor classification criteria.


Non-Hodgkin's lymphoma of prostate

description: A rare non-Hodgkin lymphoma that arises from the prostate gland.


name: Lymphoma, Small Cleaved-Cell, Follicular

description: A follicular lymphoma which contains up to 5 centroblasts per 40X high-power microscopic field.


name: Noncutaneous Childhood Anaplastic Large Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for noncutaneous childhood anaplastic large cell lymphoma based on the Ann Arbor classification criteria.


Advanced Favorable Non-Hodgkin Lymphoma

description: A clinical stage II or IV non-Hodgkin lymphoma with up to three of the following risk factors: albumin level less than 4.0 g/dl, hemoglobin level of less than 10.5 g/dl, male sex, forty-five years of age or older, stage IV disease, white cell count of at least 15,000 per cubic millimeter, absolute lymphocytic count of less than 600 per cubic millimeter or a lymphocytic count of less than 8% of the total white cell count.


name: Large B-cell lymphoma with IRF4 rearrangement

description: A large B-cell lymphoma that usually affects the Waldeyer ring and/or cervical lymph nodes and less often the gastrointestinal tract. It occurs most commonly in children and young adults and is low stage. It is characterized by a follicular, follicular and diffuse, or pure diffuse growth pattern resembling follicular lymphoma grade 3B or a diffuse large B-cell lymphoma. Most cases have IG/IRF4 rearrangements. BCL2 rearrangements are not present. Some cases that belong in this category lack an IRF4 rearrangement but have strong IRF4/MUM1 expression. This lymphoma is more aggressive than pediatric-type follicular lymphomas.


Angiocentric lymphoma recurrent

description: The reemergence of nasal type extranodal NK/T-cell lymphoma after a period of remission.


Stage IV Anaplastic Large Cell Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Refractory Immunoblastic Lymphoma

description: Immunoblastic lymphoma that is resistant to treatment.


name: Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of a follicular lymphoma to an aggressive diffuse large B-cell lymphoma.


Classical Burkitt Lymphoma

description: A Burkitt lymphoma characterized by the presence of a uniform malignant lymphocytic infiltrate that is composed of medium-sized cells with round nuclei and multiple basophilic nucleoli, abundant mitotic figures, and a starry-sky pattern due to the presence of multiple tangible body macrophages.


name: Precursor B-lymphoblastic lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Splenic marginal zone lymphoma refractory

description: Splenic marginal zone lymphoma that is resistant to treatment.


N1 diffuse large B-cell lymphoma

description: A diffuse large B-cell lymphoma that is categorized as N1 with high probability by the LymphGen algorithm. This is based on a combination of genetic features. Although N1 DLBCLs always have an activating mutation affecting NOTCH1, LymphGen can assign cases with this mutation to other classes, depending on the presence of other genetic features.


name: Immunoblastic lymphoma associated with AIDS

description: A morphologic variant of diffuse large B-cell lymphoma occurring in HIV-positive patients.


Peripheral T-Cell Lymphoma-TBX21

description: A molecular subtype of peripheral T-cell lymphoma, not otherwise specified, characterized by high expression of T-box 21 (TBX21). It is composed of a polymorphic lymphocytic infiltrate admixed with abundant inflammatory cells and is associated with a better prognosis compared to peripheral T-cell lymphoma-GATA3.


name: Secondary Choroidal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that has spread to the choroid following the initial presentation in another nodal or extranodal site.


name: Refractory ALK-Positive Large B-Cell Lymphoma

description: ALK-positive large B-cell lymphoma that is resistant to treatment.


Stage III Burkitt Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Follicular lymphoma refractory

description: Follicular lymphoma grade I, II, III that is resistant to treatment.


Follicular lymphoma recurrent

description: The reemergence of follicular lymphoma after a period of remission.


name: Limited Stage Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

description: No involvement of CNS and no involvement of bone marrow. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


T-cell lymphoma recurrent

description: The reemergence of T-cell non-Hodgkin lymphoma after a period of remission.


name: Lugano Classification Adult Non-Hodgkin Lymphoma by AJCC v8 Stage

description: A staging system for adult non-Hodgkin lymphomas based on the Lugano classification criteria. This staging system does not apply to ocular adnexal lymphomas (are staged according to the classification for ocular adnexal lymphoma), pediatric non-Hodgkin lymphomas (are staged according to the St. Jude Children's Research Hospital staging system), primary cutaneous lymphomas (are staged according to the classification for primary cutaneous lymphoma), and multiple myelomas (are staged according to the classification for plasma cell myeloma). (from AJCC 8th Ed.)


name: Refractory High Grade B-Cell Lymphoma, Not Otherwise Specified

description: High-grade B-cell lymphoma, not otherwise specified, that is resistant to treatment.


name: Stage IV Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IV includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2); IVB (T1-4, N0-3, M1, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M0: No visceral organ involvement.  M1: Visceral involvement (must have pathology confirmation and organ involved should be specified). B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1,000 per microliter or more Sezary cells with positive clone. (AJCC 8th ed.)


name: Lacrimal Drainage System Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises from the lacrimal sac.


name: Recurrent Intravascular Large B-Cell Lymphoma

description: The reemergence of intravascular large B-cell lymphoma after a period of remission.


name: Mycosis fungoides/Sezary syndrome stage IV

description: Stage IV includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2); IVB (T1-4, N0-3, M1, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative.  M0: No visceral organ involvement.  M1: Visceral involvement (must have pathology confirmation and organ involved should be specified).  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone.  (AJCC 7th ed.)


name: Primary Large B-Cell Lymphoma of Immune-Privileged Site

description: A term that refers to diffuse large B-cell lymphomas that arise as primary tumors in the central nervous system, vitreoretina, and testis in immunocompetent patients.


name: Parotid Gland Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that manifests initially in the parotid gland.


Gastric T-Cell Non-Hodgkin Lymphoma

description: A rare, extranodal T-cell non-Hodgkin lymphoma that arises from the stomach with the bulk of the mass located in the stomach.


B-cell lymphoma recurrent

description: The reemergence of B-cell non-Hodgkin lymphoma after a period of remission.


Advanced Marginal Zone Lymphoma

description: Marginal zone lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: childhood nasal type extranodal NK/T-cell lymphoma

description: A nasal type extranodal NK/T-cell lymphoma occurring in childhood.


name: Advanced Transformed Non-Hodgkin Lymphoma

description: Transformed non-Hodgkin lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Primary Cutaneous Intravascular Large B-Cell Lymphoma

description: Intravascular large B-cell lymphoma that arises from the skin.


B-cell lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Recurrent Peripheral T-Cell Lymphoma, Not Otherwise Specified

description: The reemergence of peripheral T-cell lymphoma, not otherwise specified after a period of remission.


name: Nodal marginal zone B-cell lymphoma recurrent

description: The reemergence of nodal marginal zone lymphoma after a period of remission.


name: Campylobacter Jejuni-Associated Small Intestinal Mucosa-Associated Lymphoid Tissue Lymphoma

description: A mucosa-associated lymphoid tissue lymphoma that arises from the small intestine and it is associated with Campylobacter jejuni infection.


Centroblastic lymphoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Esophageal Mucosa-Associated Lymphoid Tissue Lymphoma

description: An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the esophagus with the bulk of the mass located in the esophagus.


Recurrent Grade 3a Follicular Lymphoma

description: The reemergence of grade 3a follicular lymphoma after a period of remission.


Sporadic Burkitt's lymphoma

description: A clinical variant of Burkitt lymphoma that occurs throughout the world.  It affects both children and adults and is more frequently seen in males.


name: Extranodal marginal zone B-cell lymphoma (MALT type) stage I

description: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage I disease.


name: Lugano Classification Stage I Adult Non-Hodgkin Lymphoma AJCC v8

description: Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


Head and Neck Follicular Lymphoma

description: A follicular lymphoma that arises from the head and neck region. It usually affects older individuals, and the most common sites of involvement are the cervical lymph nodes and Waldeyer ring.


Adult T-cell lymphoma/leukemia stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Primary Pituitary Gland Diffuse Large B-Cell Lymphoma

description: A rare diffuse large B-cell lymphoma that arises from the pituitary gland.


name: Recurrent Childhood Anaplastic Large Cell Lymphoma

description: The reemergence of anaplastic large cell lymphoma in childhood after a period of remission.


name: Precursor B-lymphoblastic lymphoma refractory

description: B-lymphoblastic lymphoma that does not respond to treatment.


name: Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma

description: An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the ocular adnexa. It is the most common type of primary ocular adnexal lymphoma.


Anaplastic large B-cell lymphoma

description: A diffuse large B-cell lymphoma variant characterized by the presence of large round, oval, or polygonal cells with bizarre pleomorphic nuclei resembling Hodgkin or Reed-Sternberg cells. It is unrelated to anaplastic large cell lymphoma which is a T-cell non-Hodgkin lymphoma.


name: Stage III Childhood Lymphoblastic Lymphoma

description: Stage III: Tumors or involved lymph node areas occur on both sides of the diaphragm. Stage III also includes any primary intrathoracic (mediastinal, pleural, or thymic) disease, extensive primary intra-abdominal disease, or any paraspinal or epidural tumors (from PDQ).


Diffuse large B-cell lymphoma recurrent

description: The reemergence of diffuse large B-cell lymphoma after a period of remission.


name: Ann Arbor Stage IV Nodular Lymphocyte Predominant B-Cell Lymphoma


name: Dural Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

description: A rare, primary marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the meningeal dura.  The majority of cases have been described in middle aged women.  Radiologically, the lymphomatous dural infiltration mimics meningioma.


Recurrent Indolent Non-Hodgkin Lymphoma

description: The reemergence of indolent non-Hodgkin lymphoma after a period of remission.


Adult Immunoblastic Lymphoma

description: A morphologic variant of diffuse large B-cell lymphoma occurring in adults.  It is characterized by the presence of large lymphoid cells with abundant cytoplasm and prominent nucleoli.


Stage II Adult Lymphoblastic Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Transformed Small Lymphocytic Lymphoma to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of a small lymphocytic lymphoma to an aggressive diffuse large B-cell lymphoma.


name: B Lymphoblastic Lymphoma by Ann Arbor Stage

description: An anatomic stage for B-lymphoblastic lymphoma based on the Ann Arbor classification criteria.


name: Stage IIIB Mycosis Fungoides and Sezary Syndrome AJCC v7

description: Stage IIIB includes: T4, N0-2, M0, B1. T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


name: Recurrent Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

description: The reemergence of primary diffuse large B-cell lymphoma of the central nervous system after a period of remission.


name: Ann Arbor Stage II Non-Contiguous Aggressive Adult Non-Hodgkin Lymphoma


Childhood Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that occurs during childhood.


Parotid Gland Mantle Cell Lymphoma

description: A mantle cell lymphoma that manifests initially in the parotid gland.


name: Recurrent Childhood Non-Hodgkin Lymphoma

description: The reemergence of non-Hodgkin lymphoma in childhood after a period of remission.


name: Refractory Central Nervous System Non-Hodgkin Lymphoma

description: A central nervous system non-Hodgkin lymphoma which does not respond to treatment.


Stage II Burkitt Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Childhood Peripheral T-Cell Lymphoma, Not Otherwise Specified

description: Peripheral T-cell lymphoma, not otherwise specified, that occurs during childhood.


name: Stage II Childhood Anaplastic Large Cell Lymphoma


Head and Neck Burkitt Lymphoma

description: A Burkitt lymphoma that arises from the head and neck region. In patients with endemic Burkitt lymphoma, the jaws and other facial bones are usually affected. In patients with sporadic Burkitt lymphoma, the gingiva, orbit, and Waldeyer ring are usually affected. In patients with immunodeficiency-related Burkitt lymphoma, the lymph nodes are usually affected.


name: Refractory Primary Vitreoretinal Diffuse Large B-Cell Lymphoma

description: Primary vitreoretinal diffuse large B-cell lymphoma that does not respond to treatment.


name: Refractory Hepatosplenic T-Cell Lymphoma

description: Hepatosplenic T-cell lymphoma that is resistant to treatment.


name: HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: A large B-cell lymphoma characterized by the presence of a diffuse proliferation of large, atypical HHV8-positive neoplastic lymphocytes. It usually arises in association with HHV8-positive multicentric Castleman disease.


name: Transformed Small Lymphocytic Lymphoma to Hodgkin Lymphoma

description: Histologic transformation of small lymphocytic lymphoma to Hodgkin lymphoma.


Childhood Burkitt Lymphoma

description: A Burkitt lymphoma occurring in children.


name: Ann Arbor Stage IV Aggressive Adult Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Burkitt Lymphoma by Ann Arbor Stage

description: An anatomic stage for Burkitt lymphoma based on the Ann Arbor classification criteria.


name: Recurrent Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

description: The reemergence of primary cutaneous diffuse large B-cell lymphoma, leg type after a period of remission.


name: Breast implant-associated anaplastic large cell lymphoma

description: A rare anaplastic large cell lymphoma that develops in individuals with breast implants. It usually presents as an accumulation of seroma fluid between the implant and the surrounding fibrous capsule. The median interval from the time of the implant to the development of lymphoma is approximately 10 years.


Colorectal Non-Hodgkin Lymphoma

description: An extranodal non-Hodgkin lymphoma that arises from the colon or rectum.  The majority are B-cell non-Hodgkin lymphomas.


Esophageal Non-Hodgkin Lymphoma

description: An extranodal non-Hodgkin lymphoma that arises from the esophagus with the bulk of the mass located in the esophagus.  Dysphagia may be the presenting symptom.  The vast majority of cases are diffuse large B-cell lymphomas and B-cell lymphomas of the mucosa-associated lymphoid tissue.


name: Childhood Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

description: An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that occurs during childhood.


name: Extranodal marginal zone B-cell lymphoma (MALT type) recurrent

description: The reemergence of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue after a period of remission.


Intestinal Follicular Lymphoma

description: A follicular lymphoma arising from the intestine.  The majority of cases occur in the small intestine, particularly the duodenum.  Usually the patients have localized disease and a favorable clinical outcome.


name: Burkitt Lymphoma with Plasmacytoid Differentiation

description: Burkitt lymphoma characterized by the presence of malignant cells with eccentric basophilic cytoplasm. The nucleoli of these cells are often single and central. This morphologic variant of Burkitt lymphoma is more often seen in patients with immunodeficiency.


Angiocentric lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: non-Hodgkin's lymphoma of lacrimal gland

description: A non-Hodgkin lymphoma that arises from the lacrimal gland. The majority of cases are of B-cell type. The most common subtypes are mucosa-associated lymphoid tissue lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma.


Burkitt's lymphoma of breast

description: A Burkitt lymphoma that arises from the breast.  It usually affects pregnant or lactating women and presents with bilateral breast involvement and breast swelling.


name: B-cell small lymphocytic lymphoma refractory

description: B-cell small lymphocytic lymphoma that is resistant to treatment.


name: Ann Arbor Stage III Mature T- and NK-Cell Lymphoma


AIDS-Related Anal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma arising from the anus and occurring in HIV-positive patients.  Homosexual HIV-positive men have an increased risk of developing anal non-Hodgkin lymphoma in comparison to the general male population.  The majority of the cases are large cell lymphomas of B-cell phenotype.


name: Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

description: T-cell/histiocyte-rich large B-cell lymphoma that is resistant to treatment.


Prostate Small Lymphocytic Lymphoma

description: A rare small lymphocytic lymphoma that arises from the prostate gland.


Recurrent Childhood Burkitt Lymphoma

description: The reemergence of Burkitt lymphoma in childhood after a period of remission.


name: Nasal Cavity Extranodal NK/T-Cell Lymphoma

description: An extranodal NK/T-cell lymphoma that arises from the nasal cavity.


Pyothorax-Associated Lymphoma

description: An aggressive diffuse large B-cell lymphoma arising in the pleural cavity of patients with a history of long standing pyothorax.  Patients present with chest and back pain, fever, productive cough, dyspnea, and hemoptysis.


name: Ann Arbor Stage I Grade 1 Follicular Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Recurrent Aggressive Non-Hodgkin Lymphoma

description: An aggressive non-Hodgkin lymphoma that has recurred after a period of remission.


name: thyroid gland mucosa-associated lymphoid tissue lymphoma

description: An extranodal marginal zone B-cell lymphoma arising from mucosa-associated lymphoid tissue in the thyroid gland. The vast majority of cases are associated with chronic lymphocytic thyroiditis.


non-Hodgkin's lymphoma of nasal cavity

description: A primary non-Hodgkin lymphoma that affects the nasal cavity and the bulk of the tumor is in this anatomic area.  The majority of the cases are nasal type extranodal NK/T-cell lymphomas and diffuse large B-cell lymphomas.


Adult T-cell lymphoma/leukemia stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Primary Choroidal Non-Hodgkin Lymphoma

description: An indolent, low-grade B-cell non-Hodgkin lymphoma that arises from the choroid. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Lymphoid follicles with germinal centers may be present. In the past these tumors were termed 'reactive lymphoid hyperplasia'. Now they are considered low-grade B-cell lymphomas, most commonly extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.


name: Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

description: The reemergence of T-cell/histiocyte-rich large B-cell lymphoma after a period of remission.


name: Stage II Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

description: A single tumor (extranodal) with regional node involvement or two or more nodal areas on the same side (either above or below) of the diaphragm or two or more single (extranodal) tumors, with or without regional node involvement, on the same side (either above or below) of the diaphragm or a completely resected primary gastrointestinal tract tumor with or without involvement of associated mesenteric nodes only. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Secondary Central Nervous System Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that has spread to the central nervous system following the initial presentation in another nodal or extranodal site.


name: Intestinal T-Cell Lymphoma, Not Otherwise Specified

description: A T-cell lymphoma arising in the intestines, or sometimes other sites in the gastrointestinal tract, that does not conform to either classic enteropathy-associated T-cell lymphoma or monomorphic epitheliotropic intestinal T-cell lymphoma. (WHO 2017)


name: Ann Arbor Stage II Mature T- and NK-Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


name: Primary Cutaneous Peripheral T-Cell Lymphoma, Not Otherwise Specified

description: An exceedingly rare peripheral T-cell lymphoma that arises from the skin and does not meet the criteria that define the other well characterized primary cutaneous peripheral T-cell lymphomas, i.e., it is a diagnosis of exclusion.


name: Primary Cerebral Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises in the cerebrum.


name: diffuse large B-cell lymphoma activated B-cell type

description: A diffuse large B-cell lymphoma that is characterized by the expression of CD44, PKCbeta1, Cyclin D2, BCL-2, and IRF4/MUM1 genes.


Marginal zone lymphoma refractory

description: Marginal zone lymphoma which does not respond to treatment.


Cerebral Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises in the cerebral hemispheres as a primary lesion.


name: Ann Arbor Stage II Contiguous Adult Non-Hodgkin Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Adult Anaplastic Large Cell Lymphoma

description: An anaplastic large cell lymphoma occurring in adults.


Refractory Primary Effusion Lymphoma

description: Primary effusion lymphoma that is resistant to treatment.


name: Helicobacter Pylori-Related Non-Hodgkin Lymphoma

description: Non-Hodgkin lymphoma that is caused by Helicobacter Pylori.


Refractory Grade 3 Follicular Lymphoma

description: Grade 3 follicular lymphoma that is resistant to treatment.


Early Unfavorable Non-Hodgkin Lymphoma

description: A clinical stage I or II non-Hodgkin lymphoma with at least one of the following risk factors: large mediastinal mass, extranodal spread, elevated erythrocyte sedimentation rate, involvement of at least three lymph node areas, and B symptoms.


Thyroid Non-Hodgkin's Lymphoma

description: A non-Hodgkin lymphoma primarily involving the thyroid gland.  The vast majority of cases are either diffuse large B-cell lymphomas or extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue. Hashimoto (chronic lymphocytic) thyroiditis is almost always present.


Grade 2 Cutaneous Follicular Lymphoma

description: A cutaneous lymphoma which contains 6-15 centroblasts per 40X high-power microscopic field.


name: Refractory HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: HHV8-positive diffuse large B-cell lymphoma, not otherwise specified that is resistant to treatment.


name: Refractory Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation

description: Diffuse large B-cell lymphoma associated with chronic inflammation that is resistant to treatment.


name: Ann Arbor Stage III Grade 1 Follicular Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Fibrin-Associated Diffuse Large B-Cell Lymphoma

description: An unusual form of diffuse large B-cell lymphoma. It is not mass-forming and does not directly produce symptoms, but it is discovered incidentally on histological examination of surgical pathology specimens, excised for various pathologies other than lymphoma. The specimens typically contain fibrinous materials. Single and small aggregates of large lymphoma cells are found in only small foci within the fibrinous or amorphous material. EBV is positive, with type III latency. The clinical outcome is highly favorable, even with surgical excision alone. (WHO 2017)


Mycosis fungoides recurrent

description: The reemergence of mycosis fungoides after a period of remission.


name: Transformed B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of a B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classic Hodgkin lymphoma to an aggressive diffuse large B-cell lymphoma.


name: Anaplastic Large Cell Lymphoma, Sarcomatoid Subtype

description: A are variant of anaplastic large cell lymphoma. It is characterized by presence of large spindle shaped cells resembling a soft tissue sarcoma.


name: Stage IIB Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IIB includes: T3, N0-2, M0, B0,1. T3: One or more tumors (equal or greater than 1 cm in diameter). N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Childhood B Lymphoblastic Lymphoma

description: A B-lymphoblastic lymphoma that occurs during childhood.


Head and Neck Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that affects the head and neck region. It usually arises from the ocular adnexa, salivary glands, larynx, and thyroid gland.


name: Stage III Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage III includes: (T4, N0-2, M0, B0,1); IIIA (T4, N0-2, M0, B0); IIIB (T4, N0-2, M0, B1). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


name: Primary mediastinal large B-cell lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Colon Non-Hodgkin Lymphoma

description: An extranodal non-Hodgkin lymphoma that arises from the colon.  The majority are B-cell non-Hodgkin lymphomas.


name: Ann Arbor Stage II Contiguous Adult Burkitt Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Angioimmunoblastic T-cell lymphoma recurrent

description: The reemergence of follicular helper T-cell lymphoma, angioimmunoblastic-type after a period of remission


name: Thymic Mucosa-Associated Lymphoid Tissue Lymphoma

description: A low-grade extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that affects the thymus.  It is characterized by the presence of centrocyte-like or monocytoid lymphocytes that surround reactive lymphoid follicles.  There is infiltration of the thymic epithelium by lymphocytes and formation of lymphoepithelial lesions.  It is associated with the presence of autoimmune disease, most frequently Sjogren syndrome. Patients are usually asymptomatic and the tumor is detected incidentally as a mediastinal mass on chest x-ray.  A minority of patients present with dyspnea, hemoptysis, and chest pain.  The prognosis is excellent.


name: Recurrent Primary Vitreoretinal Diffuse Large B-Cell Lymphoma

description: The reemergence of primary vitreoretinal diffuse large B-cell lymphoma after a period of remission.


name: non-Hodgkin's lymphoma of small intestine

description: A B-cell or T-cell non-Hodgkin lymphoma that arises from the small intestine.  Representative examples of B-cell non-Hodgkin lymphoma include diffuse large B-cell lymphoma, MALT lymphoma, alpha heavy chain disease/immunoproliferative small intestinal disease, Burkitt lymphoma, follicular lymphoma, and mantle cell lymphoma.  The T-cell non-Hodgkin lymphomas are the enteropathy-associated T-cell lymphoma and the monomorphic CD56 positive intestinal T-cell lymphoma.


name: Childhood Grade III Lymphomatoid Granulomatosis

description: Grade III lymphomatoid granulomatosis that occurs during childhood.


Stage II Childhood Burkitt Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Primary Cutaneous Plasmablastic Lymphoma

description: Plasmablastic lymphoma that arises from the skin.


name: Primary Bone Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises from the bone, without lymph node or other extranodal involvement.


name: Refractory Mature B-Cell Non-Hodgkin Lymphoma

description: Mature B-cell non-Hodgkin lymphoma that does not respond to treatment.


Angiocentric lymphoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Centroblastic Lymphoma by Ann Arbor Stage

description: An anatomic stage for centroblastic lymphoma based on the Ann Arbor classification criteria.


B Lymphoblastic Lymphoma

description: An uncommon type of lymphoma.  It constitutes approximately 10% of cases of lymphoblastic lymphoma.  Approximately 75% of cases reported in a literature review involved patients who were less than 18 years of age.  The most commonly affected sites are the skin, bone, soft tissue, and lymph nodes.  It has a high remission rate with a median survival of approximately 60 months.  (WHO, 2001)


name: Central Nervous System B-Cell Non-Hodgkin Lymphoma

description: A B-cell non-Hodgkin lymphoma that arises from the brain, meninges, or spinal cord.


name: Recurrent Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

description: The reemergence of diffuse large B-cell lymphoma germinal center B-cell type after a period of remission.


name: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Involving the Digestive System

description: An extranodal low-grade B-cell non-Hodgkin lymphoma arising in mucosal or glandular tissues of the digestive system. It recapitulates the cytoarchitectural features of mucosa-associated lymphoid tissue (MALT). It is composed of small lymphoid cells, often including marginal zone cells. (WHO 2019)


name: Precursor B-lymphoblastic lymphoma recurrent

description: The reemergence of B-lymphoblastic lymphoma after a period of remission.


name: Digestive System Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises from the digestive system.


name: Nodal Marginal Zone Lymphoma by Ann Arbor Stage

description: An anatomic stage for nodal marginal zone lymphoma based on the Ann Arbor classification criteria.


name: St. Jude Stage II Childhood Non-Hodgkin Lymphoma AJCC v8

description: Stage II: A single tumor (extranodal) with regional node involvement. Two or more nodal areas on the same side of the diaphragm. Two single (extranodal) tumors with or without regional node involvement on the same side of the diaphragm. A primary gastrointestinal tract tumor, usually in the ileocecal area, with or without involvement of associated mesenteric nodes only. (from AJCC 8th Ed.)


name: Marginal Zone Lymphoma by Ann Arbor Stage

description: An anatomic stage for marginal zone lymphoma based on the Ann Arbor classification criteria.


name: Mycosis fungoides/Sezary syndrome refractory

description: Mycosis fungoides and Sezary syndrome that is resistant to treatment.


name: AIDS-Related Burkitt Lymphoma with Plasmacytoid Differentiation

description: A Burkitt lymphoma with plasmacytoid differentiation occurring in HIV-positive patients.


name: High Grade B-Cell Lymphoma with Blastoid Morphologic Features

description: A high-grade B-cell lymphoma characterized by the presence of medium-size neoplastic lymphocytes with a scant amount of cytoplasm and inconspicuous nucleoli, resembling lymphoblasts.


name: Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

description: The reemergence of primary cutaneous T-cell non-Hodgkin lymphoma after a period of remission.


name: Refractory Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

description: Diffuse large B-cell lymphoma germinal center B-cell type that is resistant to treatment.


Intestinal T-cell lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Burkitt-like lymphoma with 11q aberration

description: A molecularly distinct large B-cell lymphoma reminiscent of Burkitt lymphoma. It is characterized by the absence of MYC translocation and the presence of chromosome 11q aberrations.


Adult Non-Hodgkin Lymphoma

description: Non-Hodgkin lymphoma occurring in adults.


name: Lymphohistiocytic Variant Anaplastic Large Cell Lymphoma

description: A histologic variant of anaplastic large cell lymphoma characterized by the presence of a large number of histiocytes admixed with the anaplastic lymphoma cells.


Thyroid Immunoblastic Lymphoma

description: A diffuse large B-cell lymphoma variant, primarily involving the thyroid gland.  It is composed predominantly of immunoblasts.


Head and Neck Plasmablastic Lymphoma

description: A plasmablastic lymphoma that arises from the head and neck region. The most frequently affected site is the oral cavity.


name: Recurrent Transformed T-cell Non-Hodgkin Lymphoma

description: The reemergence of T-cell non-Hodgkin lymphoma transformed after a period of remission.


description: Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly is a rare form of diffuse large B-cell lymphoma occurring most commonly in patients over the age of 50 (usually between 70-75 years of age), without overt immunodeficiency, and presenting with nodal and extranodal involvement (in sites such as the stomach, lung, skin and pancreas) and B symptoms (fever, night sweats, weight loss). The tumor is characterized by an aggressive course and a short survival rate.


name: Childhood Anaplastic Large Cell Lymphoma, ALK-Positive

description: An anaplastic large cell lymphoma, ALK-positive that occurs during childhood.


Lymphoma, Large-Cell, Follicular

description: A follicular lymphoma which contains more than 15 centroblasts per 40X high-power microscopic field.


name: Recurrent High Grade B-Cell Lymphoma, Not Otherwise Specified

description: The reemergence of high-grade B-cell lymphoma, not otherwise specified, after a period of remission.


name: Adult T-cell lymphoma/leukemia refractory

description: Adult T-cell leukemia/lymphoma that is resistant to treatment.


name: Refractory High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements

description: High-grade B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements that is resistant to treatment.


name: B-cell small lymphocytic lymphoma recurrent

description: The reemergence of small lymphocytic lymphoma after a period of remission.


Extracavitary Primary Effusion Lymphoma

description: A rare HHV8-positive B-cell lymphoma indistinguishable from primary effusion lymphoma presenting as solid tumor mass. (WHO 2017)


name: Stage II Indolent Adult Non-Hodgkin Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Stage IV Adult Immunoblastic Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Aggressive Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma with an aggressive clinical course.  Representative examples include Burkitt lymphoma, mantle cell lymphoma, and angioimmunoblastic T-cell lymphoma.


name: Parotid Gland Mucosa-Associated Lymphoid Tissue Lymphoma

description: A low-grade extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue arising from the parotid gland. It is the most common type of non-Hodgkin lymphoma in the parotid gland and is often associated with Sjogren syndrome. The prognosis is favorable.


follicular lymphoma of salivary gland

description: A follicular lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland.


ST2 Diffuse Large B-Cell Lymphoma

description: A genetic subtype of diffuse large B-cell lymphoma characterized by SGK1 and TET2 gene mutations.


name: non-Hodgkin's lymphoma of salivary gland

description: A non-Hodgkin lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland. Mucosa-associated lymphoid tissue lymphoma is the most common primary salivary gland non-Hodgkin lymphoma.


name: Recurrent EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: The reemergence of EBV-positive diffuse large B-cell lymphoma, not otherwise specified after a period of remission.


name: Ann Arbor Stage II Grade 1 Non-Contiguous Follicular Lymphoma


name: Stage IIA Mycosis Fungoides and Sezary Syndrome AJCC v7

description: Stage IIA includes: T1-2, N1-2, M0, B0-1.  T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Non-Hodgkin's lymphoma refractory

description: A non-Hodgkin lymphoma which does not respond to treatment.


follicular lymphoma of lacrimal gland

description: A follicular lymphoma that arises from the lacrimal gland.


name: Stage IA Mycosis Fungoides and Sezary Syndrome AJCC v7

description: Stage IA includes: T1, N0, M0, B0-1.  T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Sinonasal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the sinonasal tract.


name: Ann Arbor Stage II Adult Non-Contiguous Immunoblastic Lymphoma


Angiocentric lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Immunoblastic Lymphoma Post-Transplant Lymphoproliferative Disorder

description: An immunoblastic lymphoma that arises in a patient with a history of organ transplantation.


name: Lugano Classification Stage III Adult Non-Hodgkin Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


name: Recurrent Indolent T-Cell Non-Hodgkin Lymphoma

description: The reemergence of indolent T-cell non-Hodgkin lymphoma after a period of remission.


name: Stage III Anaplastic Large Cell Lymphoma

description: Ann Arbor Classification. Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Stage II Adult Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


name: Nodal marginal zone B-cell lymphoma refractory

description: Nodal marginal zone B-cell lymphoma resistant to treatment.


name: Primary Nodal EBV-Positive T-Cell/NK-Cell Lymphoma

description: An EBV-positive T-cell/NK-cell lymphoma that arises from the lymph nodes. It is characterized by a monomorphic pattern of infiltration and abscence of the angiodestruction and necrosis seen in extranodal NK/T-cell lymphomas. These lymphomas are more common in elderly patient, or in the setting of immune deficiency. (WHO 2017)


name: Diffuse malignant lymphoma - centroblastic

description: A B-cell non-Hodgkin lymphoma composed of large noncleaved cells. This is a subtype of diffuse large B-cell non-Hodgkin lymphoma.


name: Recurrent Indolent B-Cell Non-Hodgkin Lymphoma

description: The reemergence of indolent B-cell non-Hodgkin lymphoma after a period of remission.


name: B-cell small lymphocytic lymphoma stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Recurrent Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

description: The reemergence of mature T-cell and NK-cell non-Hodgkin lymphoma after a period of remission.


name: Refractory Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma

description: Diffuse large B-cell lymphoma that resulted from the transformation of marginal zone lymphoma and is resistant to treatment.


name: Angioimmunoblastic T-cell lymphoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Early Favorable Non-Hodgkin Lymphoma

description: A clinical stage I or II non-Hodgkin lymphoma without any of the following risk factors: large mediastinal mass, extranodal spread, elevated erythrocyte sedimentation rate, involvement of at least three lymph node areas, and B symptoms.


Mycosis fungoides stage II

description: Stage II includes: IIA (T1-2, N1-2, M0, B0-1); IIB (T3, N0-2, M0, B0-1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


name: Ann Arbor Stage I Subdiaphragmatic Nodular Lymphocyte Predominant B-Cell Lymphoma


Refractory Grade 2 Follicular Lymphoma

description: Grade 2 follicular lymphoma that is resistant to treatment.


name: Leukemic Phase of Non-Hodgkin's Lymphoma

description: A usually terminal event in the clinical course of lymphomas.  The term indicates the presence of atypical, clonal (malignant) lymphocytes (lymphoma cells) in the peripheral blood.


name: Refractory Aggressive Non-Hodgkin Lymphoma

description: An aggressive non-Hodgkin lymphoma that is resistant to treatment.


name: Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Molecular Subtypes

description: Molecular subtyping of diffuse large B-cell lymphomas (DLBCL) based on structural genomic abnormalities and gene expression data obtained from biopsy samples. The molecular analysis revealed four subtypes of DLBCL (MCD, BN2, N1, and EZB) which have distinct genotypic, epigenetic, and clinical characteristics. (NEJM 2018; 378: 1396-407)


name: Lugano Classification Limited Stage Adult Non-Hodgkin Lymphoma AJCC v8

description: Limited stage adult non-Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Adult T-cell lymphoma/leukemia stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Splenic Small Lymphocytic Lymphoma

description: Small lymphocytic lymphoma occurring in the spleen.


Follicular T-cell lymphoma

description: Follicular helper T-cell lymphoma with a predominantly follicular growth pattern.


Pharyngeal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the pharynx.


Splenic Lymphoplasmacytic Lymphoma

description: A lymphoplasmacytic lymphoma  occurring in the spleen.


name: Refractory Breast Implant-Associated Anaplastic Large Cell Lymphoma

description: Breast implant-associated anaplastic large cell lymphoma that is resistant to treatment.


non-Hodgkin's lymphoma of liver

description: A rare non-Hodgkin lymphoma that arises from the liver and the bulk of the tumor is located in the liver.  The most frequent types of non-Hodgkin lymphoma that arise from the liver are diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma.


Mantle cell lymphoma refractory

description: Mantle cell lymphoma resistant to treatment.


AIDS-Related Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that develops in a patient with AIDS.


name: Primary Mediastinal Large B-Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for primary mediastinal large B-cell lymphoma based on the Ann Arbor classification criteria.


Stage II Diffuse Large B-Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Adult Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma occurring in adults.


Classic Follicular Lymphoma

description: A term that refers to follicular lymphoma grade 1, 2, and 3A.


name: Childhood Large B-Cell Lymphoma with IRF4 Rearrangement

description: A large B-cell lymphoma with IRF4 rearrangement that occurs during childhood.


ALK-positive large B-cell lymphoma

description: Anaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma is a very rare variant of diffuse large B-cell lymphoma (DLBCL) mainly affecting middle-aged immunocompetent men and characterized by a consistent primary involvement of lymph nodes (mainly in the cervical and mediastinum lymph nodes) and with infrequent extra nodal involvement of the bone marrow and other extra-nodal sites (head and neck region, liver, spleen, and gastrointestinal tract). It has an aggressive disease course, and is associated with a poor prognosis.


name: Lugano Classification Stage IE Adult Non-Hodgkin Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement. (from AJCC 8th Ed.)


Recurrent Grade 1 Follicular Lymphoma

description: The reemergence of grade 1 follicular lymphoma after a period of remission.


name: Stage I Childhood Lymphoblastic Lymphoma

description: Stage I: A single tumor or nodal area is involved, excluding the abdomen and mediastinum (from PDQ).


name: Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v7

description: Stage IB includes: T2, N0, M0, B0-1. T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


name: Anaplastic Large Cell Lymphoma, Signet Ring-Like Subtype

description: An anaplastic large cell lymphoma, characterized by lymphoid cells with signet ring nuclei.


name: Extranodal marginal zone B-cell lymphoma (MALT type) stage III

description: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage III disease.


name: Recurrent Central Nervous System Non-Hodgkin Lymphoma

description: The reemergence of central nervous system non-Hodgkin lymphoma after a period of remission.


name: Mycosis fungoides/Sezary syndrome recurrent

description: The reemergence of mycosis fungoides/Sezary syndrome after a period of remission.


Recurrent Adult Lymphoblastic Lymphoma

description: The reemergence of adult lymphoblastic lymphoma after a period of remission.


name: Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of an indolent B-cell non-Hodgkin lymphoma to an aggressive diffuse large B-cell lymphoma.


name: Adult Primary Cutaneous Anaplastic Large Cell Lymphoma

description: Primary cutaneous anaplastic large cell lymphoma that occurs in adults.


Aggressive T-Cell Non-Hodgkin Lymphoma

description: A T-cell non-Hodgkin lymphoma with an aggressive clinical course. This category includes T lymphoblastic lymphoma, anaplastic large cell lymphoma, ALK-negative, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, intestinal T-cell lymphoma, nasal type extranodal NK/T-cell lymphoma, peripheral T-cell lymphoma, not otherwise specified, and subtypes of primary cutaneous T-cell non-Hodgkin lymphoma.


name: Follicular Lymphoma with Unusual Cytological Features

description: An uncommon morphologic variant of follicular lymphoma characterized by the presence of predominantly medium-sized neoplastic lymphocytes with blastoid features or large neoplastic lymphocytes with cleaved nuclei.


name: Recurrent Systemic Anaplastic Large Cell Lymphoma, ALK-Positive

description: The reemergence of systemic anaplastic large cell lymphoma, ALK-positive after a period of remission.


name: Recurrent Mature B-Cell Non-Hodgkin Lymphoma

description: The reemergence of mature B-cell non-Hodgkin lymphoma after a period of remission.


name: Lacrimal System Mucosa-Associated Lymphoid Tissue Lymphoma

description: A mucosa-associated lymphoid tissue lymphoma that arises from the lacrimal gland or the lacrimal drainage system.


name: Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

description: Primary cutaneous diffuse large B-cell lymphoma, leg type that is resistant to treatment.


Grade 3 Cutaneous Follicular Lymphoma

description: A cutaneous lymphoma which contains more than 15 centroblasts per 40X high-power microscopic field.


Gastric Burkitt Lymphoma

description: An extranodal Burkitt lymphoma that arises from the stomach with the bulk of the mass located in the stomach.


Recurrent Non-Hodgkin Lymphoma

description: The reemergence of non-Hodgkin lymphoma after a period of remission.


name: Small Lymphocytic Lymphoma by Ann Arbor Stage

description: An anatomic stage for small lymphocytic lymphoma based on the Ann Arbor classification criteria.


name: High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements

description: High-grade B-cell lymphoma characterized by the abnormal rearrangement of MYC gene, BCL2 gene, and/or BCL6 gene. Patients with this type of lymphoma usually respond poorly to standard treatments and have a poor prognosis.


name: Diffuse large B-cell lymphoma associated with chronic inflammation

description: A diffuse large B-cell lymphoma arising in body cavities or narrow spaces of long standing chronic inflammation.  The classic example is the pyothorax-associated lymphoma that arises in the pleural cavity of patients with a history of long standing pyothorax.


name: Primary mediastinal large B-cell lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Non-Hodgkin Lymphoma During Pregnancy

description: Non-Hodgkin lymphoma that occurs during pregnancy.


Recurrent Primary Effusion Lymphoma

description: The reemergence of primary effusion lymphoma after a period of remission.


name: Enteropathy-Associated T-Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for enteropathy-associated T-cell lymphoma based on the Ann Arbor classification criteria.


name: Childhood Non-Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for childhood non-Hodgkin lymphoma based on the Ann Arbor classification criteria.


Tonsillar Mantle Cell Lymphoma

description: A rare mantle cell lymphoma that affects the tonsil and the bulk of the tumor is in this anatomic area.


name: DUSP22-R Anaplastic Large Cell Lymphoma, ALK-Negative

description: A genetic subtype of systemic anaplastic large cell lymphoma, ALK-negative characterized by rearrangement of DUSP22 gene. It tends to have a favorable prognosis.


name: Ann Arbor Stage IV Grade 3 Follicular Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Recurrent Monomorphic Epitheliotropic Intestinal T-cell Lymphoma

description: The reemergence of monomorphic epitheliotropic intestinal T-cell lymphoma after a period of remission.


name: Small Intestinal Atypical Burkitt/Burkitt-Like Lymphoma

description: A morphologic variant of Burkitt lymphoma that arises from the small intestine.  It is characterized by marked nuclear pleomorphism, abundant apoptotic debris, and the presence of tangible body macrophages.


Transformed Non-Hodgkin Lymphoma

description: Histologic transformation of a usually indolent non-Hodgkin lymphoma to an aggressive non-Hodgkin lymphoma.


Prostate Follicular Lymphoma

description: A rare follicular lymphoma that arises from the prostate gland.


Burkitt's lymphoma of kidney

description: A rare Burkitt lymphoma arising from the kidney.


name: Adult T-cell lymphoma/leukemia recurrent

description: The reemergence of adult T-cell leukemia/lymphoma after a period of remission


name: Small Lymphocytic Lymphoma with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation

description: Small lymphocytic lymphoma characterized by the presence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a better prognosis as compared to those with unmutated immunoglobulin heavy chain gene variable region rearrangements.


Unfavorable Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma with unfavorable prognosis.


name: Nodal marginal zone B-cell lymphoma stage III


name: Nodal marginal zone B-cell lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Recurrent Transformed B-Cell Non-Hodgkin Lymphoma

description: The reemergence of B-cell non-Hodgkin lymphoma transformed after a period of remission.


Refractory Grade 3a Follicular Lymphoma

description: Grade 3a follicular lymphoma that is resistant to treatment.


name: Refractory Nodular Lymphocyte Predominant B-Cell Lymphoma

description: Nodular lymphocyte predominant B-cell lymphoma that is resistant to treatment.


Primary Iris Non-Hodgkin Lymphoma

description: An extremely rare low-grade B-cell non-Hodgkin lymphoma that arises from the iris. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Most cases represent extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.


follicular lymphoma of lung

description: An exceedingly rare follicular lymphoma that arises in and is confined to the lung at the time of diagnosis.


name: Lymphoplasmacytic Lymphoma by Ann Arbor Stage

description: An anatomic stage for lymphoplasmacytic lymphoma based on the Ann Arbor classification criteria.


name: Refractory Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

description: Primary diffuse large B-cell lymphoma of the central nervous system that does not respond to treatment.


name: Lacrimal Drainage System Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the lacrimal sac. The majority of cases are of B-cell type. The most common subtypes are mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma.


name: Diffuse large B-cell lymphoma refractory

description: Diffuse large B-cell lymphoma that is resistant to treatment.


name: Recurrent HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: The reemergence of HHV8-positive diffuse large B-cell lymphoma, not otherwise specified, after a period of remission.


Mycosis Fungoides by AJCC v7 Stage

description: A term that refers to the staging of mycosis fungoides, following the rules of the TNM AJCC v7 classification system.


name: Cardiac Fibrin-Associated Diffuse Large B-Cell Lymphoma

description: A rare fibrin-associated diffuse large B-cell lymphoma that affects the heart.


name: Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma

description: A nodular lymphocyte predominant B-cell lymphoma occurring in children.


Recurrent Grade 3 Follicular Lymphoma

description: The reemergence of grade 3 follicular lymphoma after a period of remission.


name: Central Nervous System Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

description: A primary central nervous system non-Hodgkin lymphoma derived from mature or post-thymic T-cells or NK-cells.


name: Recurrent Primary Cutaneous Gamma-Delta T-Cell Lymphoma

description: The reemergence of primary cutaneous gamma-delta T-cell lymphoma after a period of remission


name: Transformed Waldenstrom Macroglobulinemia to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of Waldenstrom macroglobulinemia to an aggressive diffuse large B-cell lymphoma.


name: diffuse large B-cell lymphoma germinal center B-cell type

description: A diffuse large B-cell lymphoma that is characterized by the expression of CD10, BCL-6, A-myb, and LMO2 genes, BCL-2 translocation, and c-REL amplification.


name: Ann Arbor Stage I Mature T- and NK-Cell Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue by Ann Arbor Stage

description: An anatomic stage for extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue based on the Ann Arbor classification criteria.


AIDS-Related Primary Effusion Lymphoma

description: Primary effusion lymphoma occurring in HIV-positive patients.


Conjunctival Follicular Lymphoma

description: A follicular lymphoma that arises from the conjunctiva.


Lymphoepithelioid lymphoma

description: A variant of peripheral T-cell lymphoma, not otherwise specified. It is characterized by the presence of neoplastic small lymphocytes infiltrating the lymph nodes in a diffuse and less frequently interfollicular pattern. There is an associated proliferation of epithelioid histiocytes forming confluent clusters.


Stage IV Childhood Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Lugano Classification Stage IIE Adult Non-Hodgkin Lymphoma AJCC v8

description: Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Sezary syndrome recurrent

description: The reemergence of Sezary syndrome after a period of remission.


name: St. Jude Stage I Childhood Non-Hodgkin Lymphoma AJCC v8

description: Stage I: A single tumor (extranodal) or single anatomic area (nodal), with the exclusion of the mediastinum or abdomen. (from AJCC 8th Ed.)


Advanced Anaplastic Large Cell Lymphoma

description: Anaplastic large cell lymphoma that has spread extensively to distant anatomic sites.


name: Refractory Indolent B-Cell Non-Hodgkin Lymphoma

description: Indolent B-cell non-Hodgkin lymphoma that is resistant to treatment.


name: AIDS-Related Diffuse Large B-cell Lymphoma

description: A diffuse large B-cell lymphoma occurring in HIV-positive patients.


name: Refractory Primary Cutaneous Gamma-Delta T-Cell Lymphoma

description: Primary cutaneous gamma-delta T-cell lymphoma that is resistant to treatment.


name: Primary mediastinal large B-cell lymphoma stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Central Nervous System T-Cell Non-Hodgkin Lymphoma

description: A T-cell lymphoblastic lymphoma or a mature T-cell and NK-cell neoplasm that affects the brain, meninges, or spinal cord.


anaplastic large cell lymphoma of lung

description: A rare anaplastic large cell lymphoma that arises in the lung parenchyma.


Colorectal Mantle Cell Lymphoma

description: A mantle cell lymphoma that arises from the colon or rectum.  It often presents as a polypoid lesion.


name: Refractory Subcutaneous Panniculitis-Like T-Cell Lymphoma

description: Subcutaneous panniculitis-like T-cell lymphoma that is resistant to treatment.


name: Recurrent Aggressive Adult Non-Hodgkin Lymphoma

description: The reemergence of an aggressive adult non-Hodgkin lymphoma after a period of remission.


follicular lymphoma of thyroid gland

description: A rare follicular lymphoma primarily involving the thyroid gland.


name: Ann Arbor Stage II Supradiaphragmatic Nodular Lymphocyte Predominant B-Cell Lymphoma


name: B-cell small lymphocytic lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Conjunctival Mucosa-Associated Lymphoid Tissue Lymphoma

description: A mucosa-associated lymphoid tissue lymphoma affecting the conjunctiva.


Indolent Adult Non-Hodgkin Lymphoma

description: An indolent non-Hodgkin lymphoma occurring in adults.  Representative examples include small lymphocytic lymphoma, lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia, marginal zone B-cell lymphoma, and grade 1 and 2 follicular lymphoma.


name: Small Lymphocytic Lymphoma with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene

description: Small lymphocytic lymphoma characterized by the absence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a significantly worse prognosis as compared to those with mutated immunoglobulin heavy chain gene variable region rearrangements.


name: Noncutaneous Anaplastic Large Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for noncutaneous anaplastic large cell lymphoma based on the Ann Arbor classification criteria.


name: Refractory Systemic Anaplastic Large Cell Lymphoma, ALK-Positive

description: Systemic anaplastic large cell lymphoma, ALK-positive that is resistant to treatment.


name: Stage IIIA Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IIIA includes: T4, N0-2, M0, B0. T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). (AJCC 8th ed.)


name: Adult Non-Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for adult non-Hodgkin lymphoma based on the Ann Arbor classification criteria.


Adult B Lymphoblastic Lymphoma

description: B-lymphoblastic lymphoma that occurs in adults.


name: Nasal Type NK/T-Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for nasal type NK/T-cell lymphoma based on the Ann Arbor classification criteria.


name: Primary Cutaneous T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

description: T-Cell/histiocyte-rich large B-cell lymphoma that arises from the skin.


Intestinal T-cell lymphoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Stage I Childhood Burkitt Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Peripheral T-Cell Lymphoma-GATA3

description: A molecular subtype of peripheral T-cell lymphoma, not otherwise specified, characterized by high expression of GATA3. It is composed of a monomorphic lymphocytic infiltrate with minimal inflammation and is associated with a poor prognosis.


name: Recurrent Nodular Lymphocyte Predominant B-Cell Lymphoma

description: The reemergence of nodular lymphocyte predominant B-cell lymphoma after a period of remission.


name: Small Intestinal B-Cell Non-Hodgkin Lymphoma

description: A B-cell non-Hodgkin lymphoma that arises from the small intestine.  Representative examples include diffuse large B-cell lymphoma, mucosa-associated lymphoid tissue lymphoma, alpha heavy chain disease/immunoproliferative small intestinal disease, Burkitt lymphoma, follicular lymphoma, and mantle cell lymphoma.


name: Childhood Primary Mediastinal Large B-Cell Lymphoma

description: Primary mediastinal large B-cell lymphoma that occurs during childhood.


Mediastinal T Lymphoblastic Lymphoma

description: A precursor T-lymphoblastic lymphoma that arises from the mediastinum.  It usually presents with an anterior mediastinal mass and respiratory distress.  It may present acutely with superior vena cava syndrome.  It usually affects adolescent and young adult males.  It is treated with aggressive chemotherapy and radiation.  The prognosis is better in the pediatric patients.


name: Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

description: A T-cell non-Hodgkin lymphoma that arises from the skin and does not respond to treatment.


Indolent Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma with an indolent clinical course.


name: breast mucosa-associated lymphoid tissue lymphoma

description: An extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue that arises from the breast as a primary tumor.


name: St. Jude Stage III Childhood Non-Hodgkin Lymphoma AJCC v8

description: Stage III: Two single tumors (extranodal) on opposite sides of the diaphragm. Two or more nodal areas above and below the diaphragm. All the primary intrathoracic tumors (mediastinal, pleural, and thymic). All extensive primary intra-abdominal disease. All paraspinal or epidural tumors, regardless of other tumor site(s). (from AJCC 8th Ed.)


name: Ann Arbor Stage II Aggressive Adult Non-Hodgkin Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Double-Expressor Lymphoma

description: A diffuse large B-cell lymphoma characterized by double expression of MYC and BCL2 proteins without MYC and BCL2 gene aberrations. These lymphomas may have a worse prognosis than other diffuse large B-cell lymphomas, not otherwise specified, but they are not as aggressive as the high-grade B-cell lymphomas, with rearrangements of MYC and BCL2 and/or BCL6 genes.


name: Peripheral T-cell lymphoma unspecified refractory

description: Peripheral T-cell lymphoma, not otherwise specified that is resistant to treatment.


Recurrent Adult Non-Hodgkin Lymphoma

description: The reemergence of non-Hodgkin lymphoma in adults after a period of remission.


Adult T Lymphoblastic Lymphoma

description: T-lymphoblastic lymphoma occurring in adults.


African Burkitt's lymphoma

description: A clinical variant of Burkitt lymphoma that occurs in equatorial Africa.  The Epstein-Barr virus has been detected in all patients.  It is the most common malignancy of childhood in this area.


description: The reemergence of Waldenstrom macroglobulinemia after a period of remission.


name: Ann Arbor Stage I Nodular Lymphocyte Predominant B-Cell Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


name: Ann Arbor Stage IIX (Bulky) Non-Hodgkin Lymphoma

description: Ann Arbor Stage II non-Hodgkin lymphoma with a mass of nodes with one diameter more than 10cm or a mediastinal mass larger than one third of the transthoracic width. (Cotswolds modification)


large-cell immunoblastic lymphoma

description: Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.


name: Refractory Aggressive T-Cell Non-Hodgkin Lymphoma

description: An aggressive T-cell non-Hodgkin lymphoma that is resistant to treatment.


name: Adult T-cell lymphoma/leukemia stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Recurrent Childhood Lymphoblastic Lymphoma

description: The reemergence of lymphoblastic lymphoma in childhood after a period of remission.


name: Burkitt-Like Lymphoma Post-Transplant Lymphoproliferative Disorder

description: A Burkitt-like lymphoma that arises in a patient with a history of organ transplantation.


name: Refractory Follicular Helper T-Cell Lymphoma

description: Follicular helper T-cell lymphoma that is resistant to treatment.


name: high-grade B-cell lymphoma double-hit/triple-hit

description: A B-cell lymphoma that is characterized by the abnormal rearrangement of two genes, MYC gene and either BCL2 or BCL6 genes.


Stage I Adult Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Splenic T Lymphoblastic Lymphoma

description: T-lymphoblastic lymphoma that affects the spleen.


name: Mycosis fungoides/Sezary syndrome stage II

description: Stage II includes: IIA (T1-2, N1-2, M0, B0-1); IIB (T3, N0-2, M0, B0-1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


name: Angioimmunoblastic T-cell lymphoma stage III


Small Intestinal Follicular Lymphoma

description: A follicular lymphoma that arises from the small intestine.  It most often affects the duodenum.


name: Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood non-Hodgkin lymphoma according to the Toronto childhood cancer staging guidelines v2.


name: Nodular Lymphocyte Predominant B-Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for nodular lymphocyte predominant B-cell lymphoma based on the Ann Arbor classification criteria.


Breast T-Cell Non-Hodgkin Lymphoma

description: A T-cell non-Hodgkin lymphoma that arises from the breast as a primary tumor.  Primary T-cell non-Hodgkin lymphomas of the breast are rare.


Stage IB Mycosis Fungoides AJCC v7

description: Stage IB includes: T2, N0, M0, B0-1. T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Head and Neck Mantle Cell Lymphoma

description: A mantle cell lymphoma that affects the head and neck region. The most common site of involvement is the Waldeyer ring, usually the tonsils. Other sites of involvement include the orbit, salivary glands, and nasopharynx.


Acute Adult T-Cell Leukemia/Lymphoma

description: The most common variant of adult T-cell leukemia/lymphoma.  It is characterized by systemic disease with a leukemic phase, generalized lymphadenopathy, and skin lesions.  Hypercalcemia is commonly seen.


name: Ann Arbor Stage II Adult Contiguous Immunoblastic Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type

description: Diffuse large B-cell lymphoma activated B-cell type that is resistant to treatment.


Angiocentric lymphoma stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Recurrent Gray-Zone Lymphoma

description: The reemergence of gray-zone lymphoma after a period of remission.


name: Recurrent Diffuse Large B-Cell Lymphoma Activated B-Cell Type

description: The reemergence of diffuse large B-cell lymphoma activated B-cell type after a period of remission.


name: adult nodular lymphocyte predominant Hodgkin lymphoma

description: A nodular lymphocyte predominant Hodgkin lymphoma occurring in adults.


name: Lacrimal Drainage System Mucosa-Associated Lymphoid Tissue Lymphoma

description: A mucosa-associated lymphoid tissue lymphoma that arises from the lacrimal sac.


Non-Hodgkin Breast Lymphoma

description: A non-Hodgkin lymphoma that arises from the breast.  There is no history of extramammary breast non-Hodgkin lymphoma and ipsilateral axillary lymph node involvement does not exclude the diagnosis of primary breast non-Hodgkin lymphoma.  Most patients present with a painless breast lump.  The vast majority of cases are B-cell non-Hodgkin lymphomas.  Diffuse large B-cell lymphoma, follicular lymphoma, and extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue are the most common types of primary non-Hodgkin lymphoma of the breast.


name: Common Variant Anaplastic Large Cell Lymphoma

description: An anaplastic large cell lymphoma, characterized by CD30 positive lymphoid cells.


Parotid Gland Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the parotid gland.  Representative examples include mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma.


description: Waldenstrom macroglobulinemia with serum IgM monoclonal protein equal or more than 3 g/dL and/or at least 10% bone marrow lymphoplasmacytic infiltration but no evidence of constitutional symptoms, symptomatic anemia, or hyperviscosity. (Blood 2008, 112:2709)


name: Adult EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: An EBV-positive diffuse large B-cell lymphoma, not otherwise specified, that occurs in adults. It was originally described in patients older than 50 years, but it has been increasingly recognized in younger patients.


High grade B-cell lymphoma recurrent

description: The reemergence of high-grade B-cell lymphoma after a period of remission.


BN2 diffuse large B-cell lymphoma

description: A diffuse large B-cell lymphoma that is categorized as BN2 with high probability by the LymphGen algorithm. This is based on a combination of genetic features and BN2 DLBCLs often, but do not always, have a translocation involving the BCL6 locus and/or some combination of mutations affecting NOTCH2, TNFAIP3, BCL10 and UBE2A. This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting CD70, which can be coding or non-coding.


Follicular Lymphoma by Ann Arbor Stage

description: An anatomic stage for follicular lymphoma based on the Ann Arbor classification criteria.


Stage III Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Extranodal marginal zone B-cell lymphoma (MALT type) stage II

description: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage II disease.


name: Extranodal marginal zone B-cell lymphoma (MALT type) refractory

description: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that is resistant to treatment.


EBV-Related Burkitt Lymphoma

description: Burkitt lymphoma that is caused by Epstein-Barr virus infection.


name: Refractory Transformed Non-Hodgkin Lymphoma

description: An indolent non-Hodgkin lymphoma which has undergone histologic transformation to an aggressive non-Hodgkin lymphoma and has become resistant to treatment.


Follicular lymphoma stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Diffuse Large B-Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for diffuse large B-cell lymphoma based on the Ann Arbor classification criteria.


name: Stage I Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of a single tumor mass or nodal area, excluding the abdomen and mediastinum. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Ann Arbor Stage I Supradiaphragmatic Nodular Lymphocyte Predominant B-Cell Lymphoma


name: Burkitt Lymphoma Post-Transplant Lymphoproliferative Disorder

description: A Burkitt lymphoma that arises in a patient with a history of organ transplantation.


name: Angioimmunoblastic T-cell lymphoma stage II


folliculotropic mycosis fungoides

description: Folliculotropic mycosis fungoides is a rare variant of mycosis fungoides (MF), a form of cutaneous T-cell lymphoma, and is characterized by the presence of folliculotropic infiltrates in patch-plaque lesions usually involving the head and neck area.


Refractory Plasmablastic Lymphoma

description: Plasmablastic lymphoma that is resistant to treatment.


name: Recurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma

description: The reemergence of transformed follicular lymphoma to diffuse large B-cell lymphoma after a period of remission.


Nasopharyngeal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the nasopharynx.


name: Ann Arbor Stage II Contiguous Adult Aggressive Non-Hodgkin Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: AIDS-Related Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

description: A diffuse large B-cell lymphoma that arises from the central nervous system in AIDS patients.


name: Mature T- and NK-Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for mature T- and NK-cell non-Hodgkin lymphomas based on the Ann Arbor classification criteria.


Mantle Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for mantle cell lymphoma based on the Ann Arbor classification criteria.


name: Angioimmunoblastic T-cell lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Primary Uveal Non-Hodgkin Lymphoma

description: An indolent, low-grade B-cell non-Hodgkin lymphoma that arises from the choroid, iris, or ciliary body. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Lymphoid follicles with germinal centers may be present. In the past these tumors were termed 'reactive lymphoid hyperplasia'. Now they are considered low-grade B-cell lymphomas, most commonly extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.


name: Stage III Indolent Adult Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Centroblastic lymphoma recurrent

description: The reemergence of centroblastic lymphoma after a period of remission.


name: Recurrent Primary Cutaneous Diffuse Large B-Cell Lymphoma

description: The reemergence of primary cutaneous diffuse large B-cell lymphoma after a period of remission.