Edema Trunk

description: Swelling due to an excessive accumulation of fluid in trunk area.


Focal KATP-Associated Hyperinsulinism

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: KATP-associated hyperinsulinism in which there is an area of adenomatous beta-cell hyperplasia. This condition results from paternal recessive mutation(s) in either the ABCC8 or the KCNJ11 gene and paternal uniparental isodisomy of chromosome region 11p15 with loss of tumor suppressor genes expressed from the maternally inherited chromosome.


Locally Advanced High Grade Sarcoma

description: High-grade sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Benign Childhood Central Nervous System Neoplasm

description: A childhood neoplasm that arises from the central nervous system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Enteric campylobacteriosis

description: A gastrointestinal infection attributed to the bacteria campylobacter. It is usually contracted by consuming raw or undercooked poultry or consuming a food that has been in contact with raw poultry. It is characterized by abdominal pain, fever, and  diarrhea and usually resolves in two to five days.


Rhinovirus infection

description: An infectious process caused by rhinovirus. The virus usually causes upper respiratory infections, but can infect the lower tract as well.


Stage IVB Vulvar Cancer AJCC v6 and v7

description: Stage IVB includes: Any T, Any N, M1.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 6th and 7th eds.)


Hemophilus influenza infection

description: An infection that is caused by the organism Hemophilus influenza.


Refractory Carcinoma

description: A carcinoma that does not respond to treatment.


Multifocal Glioblastomas

description: The occurrence of multiple and independent glioblastomas that are unrelated to inherited neoplastic syndromes.


name: Metastatic Digestive System Neuroendocrine Tumor G3

description: Digestive system neuroendocrine tumor G3 that has spread from its original site of growth to another anatomic site.


Gastroenteritis enteroviral

description: Gastroenteritis resulting from an infection with enterovirus.


Accelerated Phase Primary Myelofibrosis

description: Rapid progression of primary myelofibrosis, characterized by the presence of myeloblasts accounting for 10-19% of the peripheral blood white cells or the nucleated cells in the bone marrow.


name: Resectable Platinum-Resistant Malignant Germ Cell Tumor

description: A platinum-resistant malignant germ cell tumor that is amenable to surgical resection.


name: Childhood Favorable Prognosis Hodgkin Lymphoma

description: A Hodgkin lymphoma with favorable prognosis that occurs during childhood.


Swelling

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Enlargement; expansion in size; sign of inflammation


Advanced Gallbladder Carcinoma

description: Gallbladder carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Prostate Carcinoma by Gene Expression Profile

description: A header term that includes the following prostate carcinoma subtypes determined by gene expression profiling: luminal A prostate carcinoma, luminal B prostate carcinoma, and basal-like prostate carcinoma.


Prostatic Basal Cell Hyperplasia

description: A type of prostatic hyperplasia.  It is characterized by the presence of nodules of dark basal cells around residual prostatic secretory cells.


name: Recurrent Acute Myeloid Leukemia Not Otherwise Specified

description: The reemergence of acute myeloid leukemia not otherwise specified after a period of remission.


Benign neoplasm of cranial nerves

description: A neoplasm that arises from a cranial nerve and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Refractory Acute Leukemia of Ambiguous Lineage

description: Acute leukemia of ambiguous lineage that is resistant to treatment.


Childhood Giant Cell Glioblastoma

description: A giant cell glioblastoma that occurs during childhood.


Syphilitic endocarditis

description: Endocarditis secondary to syphilis.


Non-Neoplastic Retinal Disorder

description: A non-neoplastic disorder that affects the retina.


description: The reemergence of a myelodysplastic/myeloproliferative neoplasm after a period of remission.


name: Childhood Acute Myeloid Leukemia Not Otherwise Specified

description: Acute myeloid leukemias that occur in childhood and do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related.  This category includes entities classified according to the French-American-British classification scheme.


Cervical Blue Nevus

description: A nevus that arises from the cervix. It is characterized by the presence of benign, heavily pigmented dendritic melanocytes.


name: Dyspnea with No Physical Activity Limitation

description: Dyspnea that does not interfere with their physical activity.


description: Gastritis that is characterized by erosion of the mucosal surface.


Congenital Disruption

description: A morphologic defect of an organ, part of an organ, or a larger region of the body that results from the extrinsic breakdown of, or an interference with, an originally normal developmental process.


Transient Organic Mental Disorder

description: An organic mental disorder that is temporary in nature.


Atrial Septum Lipomatous Hypertrophy

description: A condition in which deposits of fat accumulate within the interatrial septum.


name: EBV-Related Clonal Post-Transplant Lymphoproliferative Disorder

description: A clonal lymphoproliferative disorder that develops following organ transplantation and is associated with Epstein-Barr virus infection.


name: Shared Neoantigen-Positive Malignant Solid Neoplasm

description: A malignant solid neoplasm that expresses unique tumor-specific neoantigens across a subset of patients.


Radiation-Related Sarcoma

description: A sarcoma that arises in the bones or soft tissues following exposure to ionizing or non-ionizing radiation.


name: Recurrent Chronic Myelomonocytic Leukemia

description: The reemergence of chronic myelomonocytic leukemia after a period of remission.


Appendix Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the appendix. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Stage IA1 Cervical Cancer AJCC v9

description: Stage IA1 includes: T1a1, N0, M0. T1a1: Tumor with measured stromal invasion equal or less than 3 mm in depth. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Acute Myeloid Leukemia with t(3;12)(q26.2;p13.2); ETV6-MECOM

description: An acute myeloid leukemia associated with t(3;12)(q26.2;p13.2) resulting in the expression of ETV6-MECOM fusion gene.


name: Advanced Gastric Neuroendocrine Carcinoma

description: A gastric neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Connective and Soft Tissue Disorder

description: A non-neoplastic or neoplastic disorder that affects the connective and soft tissue.


name: Metastatic Proximal Gastric Adenocarcinoma

description: A proximal gastric adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Skin Basal Cell Carcinoma with Adnexal Differentiation

description: A basal cell carcinoma of the skin that is characterized by adnexal differentiation.


name: Central Nervous System Histiocytic and Dendritic Cell Neoplasm

description: A neoplasm that originates from histiocytes and accessory cells and affects the central nervous system.  It is usually associated with the presence of identical tumors outside the central nervous system.  Representative examples include Langerhans cell histiocytosis, histiocytic sarcoma, and follicular dendritic cell sarcoma.


Pharyngolaryngeal Pain

description: Painful sensation in the pharyngolaryngeal region.


name: Metastatic Bladder Nested Urothelial Carcinoma

description: Bladder nested urothelial carcinoma that has spread to another anatomic site.


name: Perianal Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process involving the squamous epithelium of the perianal skin. Clinically, it usually presents as a white or red area in the perianal skin. Morphologically, it is characterized by full thickness dysplasia of the squamous epithelium and sometimes of the pilosebaceous epithelium. Human papillomavirus DNA sometimes may be identified in the dysplastic epithelium. It may recur after treatment, however only a small percentage of cases progress to squamous cell carcinoma.


Infectious Mediastinitis

description: An acute or chronic infectious process affecting the mediastinum.


Placenta, Retained

description: After delivery of neonate, placental retention that requires clinical intervention such as manual extraction, curettage or uterotonic medications.


name: Merkel Cell Polyoma Virus-Positive Merkel Cell Carcinoma

description: A Merkel cell carcinoma that is associated with Merkel cell polyoma virus infection.


Infratentorial Glioblastoma

description: A glioblastoma that occurs in the infratentorial region.


name: Mixed Epithelial and Mesenchymal Hair Follicle Neoplasm

description: A trichoblastoma characterized by the presence of neoplastic epithelial cell forming nodules. There are palisaded basaloid cells present at the periphery and pale larger cells with vesicular nuclei, prominent nucleoli, and abundant cytoplasm present at the center of the nodules. The epithelial cells are admixed with numerous small lymphocytes and occasional large multinucleated cells that resemble Reed-Sternberg cells.


name: Congenital Abnormalities of Erythrocyte Differentiation or Function

description: Inherited disorders involving abnormalities of red blood cell function, structure, or production. Some diseases in this group may be associated with bone marrow failure, neutropenia, and/or thrombocytopenia.


name: Metastatic malignant neoplasm to bone marrow

description: The spread of a malignant neoplasm from its original site of growth to the bone marrow.


name: Utricle-Associated Mucosal Gland Hyperplasia

description: A benign microacinar proliferation occurring exclusively in the area of the utricle.


Acquired Cytomegaloviral Infection

description: An infection with the Cytomegalovirus that is not present from birth.


Biliary System Disorder

description: A non-neoplastic or neoplastic disorder that affects the intrahepatic or extrahepatic bile ducts or the gallbladder. Representative examples of non-neoplastic disorders include cholangitis and cholecystitis. Representative examples of neoplastic disorders include extrahepatic bile duct adenoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.


Adrenal Gland Hyperplasia II

description: Decreased activity of the enzyme 3-beta-hydroxysteroid dehydrogenase, associated with mutation(s) in the HSD3B2 gene. The lack of activity of this enzyme produces a type of congenital adrenal hyperplasia.


Refractory Gastric Adenocarcinoma

description: Gastric adenocarcinoma that is resistant to treatment.


Stage IV Vaginal Cancer AJCC v6 and v7

description: Stage IV includes: IVA: (T4, Any N, M0) and IVB: (Any T, Any N, M1).  T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify tumor as T4).  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 6th and 7th eds.)


Early Stage Cervical Carcinoma

description: A stage term that refers to cervical carcinoma stages IA, IB, and IIA.


name: Unresectable Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: Extrapulmonary small cell neuroendocrine carcinoma that is not amenable to surgical resection.


Granuloma of conjunctiva

description: A granuloma located on the conjunctiva, usually involving the inner surface of the eyelid.


Terminal Hematuria

description: Gross hematuria that occurs at the end of, or immediately after voiding.


name: Unresectable Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that is not amenable to surgical resection.


name: Prostatic Clear Cell Cribriform Hyperplasia

description: A rare type of prostatic hyperplasia. It is characterized by hyperplastic glandular cells with clear cytoplasm.


Metastatic Malignant Mesothelioma

description: Malignant mesothelioma that has spread from its original site of growth to another anatomic site.


Stage IA Fallopian Tube Cancer AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Fallopian tube cancer with tumor limited to fallopian tube surface; no malignant cells in ascites or peritoneal washings N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Digestive System Small Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from any part of the gastrointestinal system.  It is characterized by the presence of malignant small cells.


Early Localized Lyme Disease

description: An early stage of Lyme disease that may present within 3-30 days after a tick bite with a red, concentrically-expanding rash (erythema migrans), fatigue, chills, fever, headache, muscle and joint aches, and swollen lymph nodes.


Receptor Status

description: Refers to the presence or absence of specific receptor molecules on the surface of a cells in a specimen.


Deficiency of vitamin D3

description: Abnormally low concentration of vitamin D3 (cholecalciferol) in the blood.


Abdominal Abscess

description: An abscess within the abdomen.


Arteriovenous fistula thrombosis

description: Partial or complete occlusion of the lumen within an arteriovenous fistula by a thrombus.


Stage IIIA Anal Cancer AJCC v8

description: Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor 2 cm or smaller. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. N1: Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Locally Advanced Small Cell Neuroendocrine Carcinoma

description: A small cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Benign Hair Follicle Neoplasm

description: A neoplasm that arises from the hair follicle and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Childhood Breast Neoplasm

description: A neoplasm that affects the breast and occurs during childhood.


Nutritional Calcium Deficient Rickets

description: Nutritional rickets due to dietary deficiency of calcium.


name: Hypogonadotropic Hypogonadism with Adrenal Hypoplasia Congenita

description: Hypogonadotropic hypogonadism with congenital adrenal hypoplasia associated with mutation(s) in the NR0B1 gene (on the X chromosome).


Adult Atypical Meningioma

description: An atypical meningioma that occurs during adulthood.


Neurological ventriculitis

description: Inflammation of a cerebral ventricle.


IgM Monoclonal Gammopathy

description: An abnormal laboratory test result indicating the presence of IgM monoclonal immunoglobulin in the blood or urine.


name: Stage IIIB Esophageal Adenocarcinoma AJCC v7

description: Stage IIIB includes: T3, N2, M0, Any G. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Radiating Chest Pain Along Right Upper Sternal Border

description: The location of the radiating chest pain is along the right upper sternal border.


Obstructed Megaureter

description: A megaureter in which there is obstruction to the flow of urine at the ureterovesical junction.


Hindgut Neuroendocrine Tumor G2

description: A neuroendocrine tumor grade 2 that arises from the sigmoid colon, descending colon, or rectum.


name: Locally Advanced Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Breast hyperplasia

description: A general term that refers to hyperplastic proliferations of the epithelial cells in the breast parenchyma.  Examples include atypical ductal hyperplasia, usual ductal hyperplasia, columnar cell hyperplasia, and atypical lobular hyperplasia.


Testicular Cystic Trophoblastic Tumor

description: A rare trophoblastic neoplasm that arises in metastatic sites of testicular mixed germ cell tumors following chemotherapy, or is part of treated or untreated testicular mixed germ cell tumors, or is secondary to either chemotherapy-induced or spontaneous regression of testicular choriocarcinoma. It is characterized by the presence of cysts lined by squamoid trophoblastic cells. The cysts are often compressed surrounded by other germ cell components.


Genitourinary Signs and Symptoms

description: Patient complaints (symptoms), physical or laboratory findings (signs) related to the genitourinary system.


name: Recurrent Polymorphous Low Grade Neuroepithelial Tumor of the Young

description: The reemergence of polymorphous low-grade neuroepithelial tumor of the young after a period of remission.


Malignant neoplasm of bladder recurrent

description: The reemergence of a malignant bladder neoplasm after a period of remission.


Gastrointestinal carcinoma in situ

description: An intraepithelial carcinoma arising from any part of the digestive system without evidence of invasion.


Lumbar Meningocele

description: A congenital abnormality in the lumbar region of the spine in which the meninges protrude through a defect in the spinal column.


name: Metastatic Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: Extrapulmonary large cell neuroendocrine carcinoma that has spread to another anatomic site.


name: Clinical Stage 0 Cutaneous Melanoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Oropharyngeal candidiasis

description: Infection of the oropharynx with, or disease caused by, Candida, especially C. albicans. This disease usually results from debilitation (as in immunosuppression and especially AIDS), physiologic change, prolonged administration of antibiotics, and iatrogenic and barrier breakage. SYN candidosis, moniliasis.


name: Unresectable Genitourinary System Carcinoma

description: Genitourinary system carcinoma that is not amenable to surgical resection.


Primary Cutaneous Mucinous Carcinoma

description: A rare low-grade carcinoma of the sweat glands. The most common sites are eyelids, scalp, axilla, face and trunk. It is histologically characterized by proliferating ducts until the overproduction of mucin creates islands of tumor cells, essentially floating in mucinous pools (Rosai J. Ackerman's Surgical Pathology).


name: Unresectable Vulvar Squamous Cell Carcinoma

description: Vulvar squamous cell carcinoma that is not amenable to surgical resection.


Lupus encephalitis

description: Encephalitis that is associated with systemic lupus erythematosus.


Childhood depression

description: Similar to depression in adults, childhood depression is characterized by a prolonged depressed or irritable mood accompanied by a significant loss of interest in activities, changes in appetite or sleep, decreased energy, feelings of worthlessness, and/or recurrent thoughts of death or suicide.


Adult Astroblastoma, MN1-Altered

description: An astroblastoma, MN1-altered that occurs during adulthood.


Stage IIB Esophageal Carcinoma

description: Stage IIB includes: For squamous cell carcinoma: (T2-3, N0, M0, G2-3, Tumor location: Upper, middle); (T1-2, N1, M0, Any G, Tumor location: Any).  For adenocarcinoma: (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


name: Acute Leukemia of Ambiguous Lineage, Not Otherwise Specified

description: Acute leukemia of ambiguous lineage, expressing combinations of markers that do not allow for its classification as either acute undifferentiated leukemia or mixed phenotype acute leukemia, and definitive classification along a single lineage is difficult. (WHO 2017)


Unresectable Esophageal Carcinoma

description: A carcinoma that arises from the esophagus and is not amenable to surgical resection.


Papillary mucinous cystadenocarcinoma

description: An invasive adenocarcinoma characterized by cystic changes, papillary growth pattern, and the presence of malignant glandular cells which contain intracytoplasmic mucin.


name: Metastatic Primary Malignant Brain Neoplasm

description: A malignant neoplasm that arises from the brain and has spread from its original site of growth to other sites.


Gastric Hepatoid Adenocarcinoma

description: A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of large polygonal malignant cells with eosinophilic cytoplasm resembling hepatocytes.


Anal squamous cell carcinoma metastatic

description: Anal squamous cell carcinoma that has spread from its primary site to another anatomic site.


name: Recurrent Endometrial Clear Cell Adenocarcinoma

description: The reemergence of endometrial clear cell adenocarcinoma after a period of remission.


Bone Sarcoma by AJCC v7 Stage

description: A term that refers to the staging of bone sarcoma, following the rules of the TNM AJCC v7 classification system.


CTRP Clinical Finding

description: A finding concept that has been requested by CTRP to be used in the disease field for abstraction and search of clinical trials.


Fever of Unknown Origin

description: A febrile process with an etiology that is not apparent or yet determined.


name: Recurrent Large Cell Neuroendocrine Carcinoma

description: The reemergence of large cell neuroendocrine carcinoma after a period of remission.


Diffuse neurofibroma

description: A rare neurofibroma with an infiltrative growth pattern.  It involves the skin and subcutaneous tissue and grows in a plaque-like fashion.  Malignant transformation is rare.


Gastric Carcinoma with Lymphoid Stroma

description: A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of prominent lymphocytic stromal infiltration and poorly formed tubular structures.


name: Myelodysplastic/Myeloproliferative Neoplasm, Not Otherwise Specified

description: A myelodysplastic/myeloproliferative neoplasm that does not meet the criteria of other myelodysplastic/myeloproliferative neoplasms, myelodysplastic syndromes, and myeloproliferative neoplasms. It is associated with cytopenia, blasts less than 20% in bone marrow and peripheral blood, thrombocytosis, and absence of genetic abnormalities associated with myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions.


Acute Pain

description: A sensation of discomfort or distress that has a severe or rapid onset.


Naevus spider acquired

description: A non-congenital, benign vascular lesion with a central punctum (arteriole) that is surrounded by thin-walled capillaries in a radial pattern. It occurs as the result of the dilatation of pre-existing vessels and is most often an incidental finding. The lesion may also be found in association with hypermetabolic states or chronic disease.


name: Metastatic Malignant Neoplasm in the Pelvic Cavity

description: The spread of a malignant neoplasm from a primary site to the pelvic cavity.


name: Childhood Acute Lymphoblastic Leukemia CNS-Negative Toronto Guidelines v2

description: No clinical signs of CNS involvement and no blasts in CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Refractory Acute Undifferentiated Leukemia

description: Acute undifferentiated leukemia that does not respond to treatment.


Stage IV Urethral Cancer AJCC v8

description: Stage IV includes: (T4, N0, M0); (T4, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: For male penile urethra and female urethra: Tumor invades other adjacent organs (e.g., invasion of the bladder wall). For prostatic urethra: Tumor invades other adjacent organs (e.g., extraprostatic invasion of the bladder wall, rectal wall). N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. N2: Multiple regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Parainfluenza Virus Infections

description: A viral infection caused by a parainfluenza virus, typically resulting in infections of the lower respiratory tract.


name: Skin disorder arising from mental factors

description: A skin disorder for which mental factors play a causative role.


Aleukemic myeloid leukemia

description: Myeloid leukemia presenting with leukemic infiltration of tissues and normal or decreased leukocyte count in the peripheral blood.


Virus-Related Carcinoma

description: Carcinoma that develops in the context of an individual infected with a virus.


Vulvar Melanocytic Nevus

description: A benign, atypical, or dysplastic melanocytic nevus that arises from the vulva.


Enterotoxigenic E coli Infection

description: A pathotype of Escherichia coli, which is a gram-negative bacteria that is transmitted through the fecal-oral route. It has an incubation period of 10-72 hours and a duration of 1-5 days. Symptoms may include acute, occasionally severe diarrhea without fever.


name: Complete Atrioventricular Canal Defect Balanced

description: Atrioventricular septal defect in which the atrioventricular junction is shared evenly between the left ventricle and right ventricle.


Benign Liver Non-Epithelial Neoplasm

description: A non-epithelial neoplasm that arises from the liver and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include hemangioma, angiomyolipoma, and solitary fibrous tumor.


Endometrioid intraepithelial neoplasia

description: A neoplastic clonal expansion of endometrial glands characterized by cytologic changes of the epithelium and the presence of an increased number of endometrial glands. The glands form crowded aggregates with tubular or branching patterns which are cytologically distinct from the background architectural and cytological pattern. It is associated with molecular changes seen in endometrioid endometrial carcinoma, including microsatellite instability, PAX2 inactivation, and PTEN, KRAS, and CTNNB1 gene mutations.


name: AIDS-Related Malignant Cervical Neoplasm

description: A malignant neoplasm that arises from the cervix in a patient with acquired immunodeficiency syndrome. This category includes cervical carcinoma, Kaposi sarcoma, and non-Hodgkin lymphoma.


Pericarditis secondary to uremia

description: Inflammation of the pericardium associated with chronic kidney failure.


Refractory Chronic Leukemia

description: Chronic leukemia that is resistant to treatment.


Testicular cancer metastatic

description: A malignant germ cell tumor that arises from the testis and has spread to another anatomic site.


name: Non-Functioning Pancreatic Neuroendocrine Tumor G1

description: A low grade well differentiated neoplasm with neuroendocrine differentiation that arises from the pancreas. It is characterized by the absence of a hormone-related clinical syndrome.


name: Childhood Connective and Soft Tissue Neoplasm

description: A soft tissue or bone neoplasm that occurs during childhood.


name: Arterial Thrombosis Related to Vascular Access Complication

description: The formation of a thrombus in the artery as a direct result of an activity associated with vascular access.


name: Lugano Classification Stage I Hodgkin Lymphoma AJCC v8

description: Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


name: Malignant Osteoclastic Giant Cell-Rich Tumor of Bone

description: A giant cell tumor that arises from the bone and is characterized by the presence of a malignant cellular component.


name: Refractory Sclerodermatous Graft Versus Host Disease

description: Sclerodermatous Graft Versus Host Disease that is resistant to treatment.


Infectious Encephalomyelitis

description: An infectious process that affects the brain and spinal cord tissues. It is usually caused by viruses.


Acral nevus

description: A melanocytic nevus that arises from the palms, soles, and nails.


name: Early T Precursor Acute Lymphoblastic Leukemia with BCL11B Rearrangement

description: An early T precursor acute lymphoblastic leukemia associated with the presence of BCL11B gene rearrangement.


Stage IIA2 Cervical Cancer AJCC v8

description: Stage IIA2 includes: T2a2, Any N, M0. T2a2: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion more than 4.0 cm in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


name: Acute Myeloid Leukemia with STAG2 Mutation

description: An acute myeloid leukemia associated with STAG2 gene mutation.


Liver Germ Cell Tumor

description: A benign or malignant extragonadal germ cell tumor that arises from the liver. Representative examples include teratoma and yolk sac tumor.


name: Refractory Fallopian Tube Mucinous Adenocarcinoma

description: Fallopian tube mucinous adenocarcinoma that is resistant to treatment.


name: Borrelia Burgdoferi-Associated Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: Primary cutaneous marginal zone lymphoproliferative disorder that arises from chronically stimulated lymphoid tissue in the skin in response to Borrelia burgdoferi infection.


Indirect Contact Transmission Infection

description: Infection transmitted by water, food or other means of conveyance.


Adolescent Gynecomastia

description: Gynecomastia that occurs during puberty and is not due to exogenous substances or disease processes.


name: Anal Canal Cancer by AJCC v6 and v7 Stage

description: A term that refers to the staging of anal canal cancer according to the American Joint Committee on Cancer, 6th and 7th editions. This staging system applies to carcinomas arising in the anal canal only; melanomas, carcinoid tumors, sarcomas, and perianal tumors are not included. (from AJCC 6th and 7th Eds.)


name: Chest Pain in Right Fifth Intercostal Space

description: The location of the chest pain is within the fifth intercostal space on the right side.


name: Refractory T Acute Lymphoblastic Leukemia

description: T-acute lymphoblastic leukemia that does not respond to treatment.


Metastatic Acral Lentiginous Melanoma

description: Acral lentiginous melanoma that has spread from its original site of growth to another anatomic site.


name: Human Papillomavirus-Related Vaginal Adenocarcinoma

description: An adenocarcinoma that arises from the vagina and is caused by human papillomavirus infection.


name: Recurrent HIV-Related Lymphoproliferative Disorder

description: The reemergence of HIV-associated lymphoproliferative disorder after a period of remission.


name: Testicular Spermatocytic Tumor with Sarcoma

description: A malignant germ cell tumor that arises from the testis and is characterized by the presence of a spermatocytic tumor component that is contiguous with an undifferentiated or differentiated sarcomatous component.  It usually presents as a slowly growing mass that enlarges very rapidly soon after the initial diagnosis.


name: Metastatic Gastric Neuroendocrine Carcinoma

description: A gastric neuroendocrine carcinoma that has spread from its original site of growth to another anatomic site.


name: Progesterone Receptor-Positive Malignant Neoplasm

description: A malignant neoplasm that is positive for progesterone receptors.


description: Myelofibrosis that develops in a patient with history of essential thrombocythemia.


name: Locally Advanced Digestive System Carcinoma

description: Digestive system carcinoma that has spread to nearby tissues or lymph nodes.


Metastatic Benign Neoplasm

description: A very rare benign neoplasm that metastasizes inexplicably. This category includes metastasizing pleomorphic adenoma of the salivary gland and uterine corpus metastasizing leiomyoma.


name: Refractory Malignant Urinary System Neoplasm

description: Malignant urinary system neoplasm that is resistant to treatment.


Signet Ring Melanoma

description: A rare variant of cutaneous melanoma, characterized by the presence of malignant cells with signet-ring morphology.


Mucosal lentiginous melanoma

description: An acral lentiginous melanoma affecting mucosal surfaces.


Childhood Junctional Nevus

description: A junctional nevus that occurs during childhood.


Hypoxic-Ischemic Encephalopathy

description: Ischemic brain damage in which the entire brain is deprived of oxygen. It may be fatal or lead to long term disabilities including developmental delays, intellectual disability, and seizures.


Adult Grade III Meningioma

description: A grade III meningioma that occurs during adulthood.


Grade I Meningioma

description: A benign meningioma which may recur in approximately 7-20% of the cases.  This category includes the angiomatous meningioma, fibrous meningioma, lymphoplasmacyte-rich meningioma, meningothelial meningioma, metaplastic meningioma, microcystic meningioma, psammomatous meningioma, secretory meningioma, and transitional meningioma.


Stage II Vulvar Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Phantom Limb Syndrome

description: Paresthesia or discomfort experienced post-amputation.


Recurrent Laryngeal Nerve Paralysis

description: Paralysis of the recurrent laryngeal nerve. Causes include surgical and non-surgical traumas, neoplasms (e.g., lung carcinoma), and inflammatory neuritis.


name: Recurrent Central Nervous System Lymphoma

description: The reemergence of central nervous system lymphoma after a period of remission.


Kidney Paraganglioma

description: An extremely rare paraganglioma that arises from the renal hilum. Paragangliomas that arise from the perihilar sympathetic ganglia are not included in this category.


name: Digestive System Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the digestive system. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


name: High Grade Prostatic Intraepithelial Neoplasia, Mucinous Variant

description: High grade prostatic intraepithelial neoplasia characterized by the presence of masses of mucin within the affected distended glands.


name: Stage M0 Childhood Ependymoma by Toronto Guidelines v2

description: No visible disease on imaging (MRI brain and spine) beyond primary site of disease and no tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Malignant neoplasm of stomach recurrent

description: The reemergence of a malignant neoplasm of the stomach after a period of remission.


Stage I Cervical Cancer AJCC v8

description: Stage I includes: T1, Any N, M0. T1: Tumor confined to uterus (extension to corpus should be disregarded). M0: No distant metastasis. (AJCC 8th Ed.)


Blastic Granulocytic Sarcoma

description: A granulocytic sarcoma composed primarily of myeloblasts (WHO 2001).


Childhood NUT Carcinoma

description: A NUT carcinoma that occurs during childhood.


name: Lobular Endocervical Glandular Hyperplasia

description: Lobular proliferations of benign-appearing small to moderate sized endocervical glands in the inner half of the cervical stroma. The glands are lined by columnar epithelial cells which contain pyloric gland-type mucin. There is minimal atypia and mitotic figures are rare. Some cases have been associated with adenocarcinoma in situ/high grade cervical glandular intraepithelial neoplasia and gastric-type adenocarcinomas.


Paratesticular Serous Cystadenoma

description: A rare serous cystadenoma that arises from the paratesticular structures.


name: Clonal Cytopenia with Monocytosis of Undetermined Significance

description: A myelodysplastic/myeloproliferative neoplasm that fulfills the diagnostic criteria of clonal monocytosis of undetermined significance and is associated with cytopenia.


Stage II Pancreatic Cancer AJCC v8

description: Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Radiation-Related Osteosarcoma

description: A high grade osteosarcoma arising in an irradiated bone.


recurrent adult acute myeloid leukemia

description: The reemergence of acute myeloid leukemia in adults after a period of remission.


name: No Specific Molecular Profile Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma characterized by the absence of POLE gene mutations, mismatch repair (MMR) deficiency, and p53 gene mutations.


Pancreatic Intraductal Neoplasms

description: A group of cystic or mass-forming epithelial neoplasms that arise from the exocrine pancreas, exhibit ductal differentiation, and grow mostly within the pancreatic ducts.  This group includes the pancreatic intraductal papillary mucinous neoplasms and the pancreatic intraductal tubulopapillary neoplasms.


Great vessel abnormalities

description: A congenital vascular abnormality that affects the great vessels and/or aortic arch. Representative examples include double aortic arch, aortic coarctation, and absence of a pulmonary artery.


Stage I Appendix Carcinoma AJCC v7

description: Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Radiation-Induced Vascular Disease

description: A vascular disease caused by radiation.


name: Metastatic Sarcomatoid Urothelial Carcinoma

description: Sarcomatoid urothelial carcinoma that has spread to another anatomical site.


name: Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8

description: Stage IIIB includes: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Gangliocytoma

description: The reemergence of gangliocytoma after a period of remission.


Gallbladder Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the gallbladder. The Ki-67 index is higher than 20%.


name: Blood coagulation disorder due to liver disease

description: A disorder of blood clotting that is attributable to a deficiency in liver function.


Pathological Gynecomastia

description: Gynecomastia that is due to exogenous substances or disease processes.


Pedunculated conjunctival papilloma

description: A papilloma that arises from the conjunctival squamous epithelium. It is associated with human papillomavirus infection.


Benign Intracranial Neoplasm

description: A neoplasm that involves the intracranial area and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Clinical Stage IVB Esophageal Adenocarcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Chronic Insomnia

description: Insomnia that has persisted at least one month.


New Onset Diabetes After Transplant

description: Development of diabetes after transplant, usually associated with calcineurin inhibitor use.


Localized Prostate Carcinoma

description: A carcinoma that arises from the prostate and has not spread to other anatomic sites.


name: Metastatic Malignant Nongerminomatous Germ Cell Tumor

description: A malignant nongerminomatous germ cell tumor that has spread from its original site of growth to another anatomic site.


Recurrent Meningioma

description: The reemergence of a meningioma after a period of remission.


Well Differentiated Malignant Neoplasm

description: A malignant neoplasm with morphological features reminiscent of the tissue from which it arose.


name: Ampulla of Vater Neuroendocrine Neoplasm

description: A neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and periampullary region. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


Ovarian Leydig Cell Hyperplasia

description: An increased number of Leydig cells in the hilar region of the ovary. (WHO 2020)


Stage IV Merkel Cell Carcinoma AJCC v7

description: Stage IV includes: Any T, Any N, M1.  M1: Metastasis beyond regional lymph nodes. (AJCC 7th Ed.)


Stage 0 Anal Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: High-grade squamous intraepithelial lesion (previously termed carcinoma in situ, Bowen disease, anal intraepithelial neoplasia II-III, high-grade anal intraepithelial neoplasia). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Endometrial Carcinoma

description: A carcinoma that arises from the endometrium and has metastasized to another anatomic site.


Digestive System Hodgkin Lymphoma

description: A Hodgkin lymphoma that arises from any part of the digestive system, with the bulk of the disease localized to that site.


Refractory Skin Squamous Cell Carcinoma

description: Skin squamous cell carcinoma that does not respond to treatment.


name: Simple Hamartoma of the Retinal Pigment Epithelium

description: A retinal hamartoma that involves only the retinal pigment epithelium. (WHO 2018)


Acute Myeloid Leukemia with del(17p)

description: Acute myeloid leukemia associated with deletion of the short arm of chromosome 17 [del(17p)].


mCode Non-Neoplastic Disease/Finding

description: Terminology related to non-neoplastic diseases and findings that was developed to support the efforts of Minimal Common Oncology Data Elements (mCode), a data standard designed to increase high-quality data for all cancer types.


Refractory Myxoid Liposarcoma

description: Myxoid liposarcoma that does not respond to treatment.


name: Esophageal Adenocarcinoma by AJCC v7 Stage

description: A term that refers to the staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 7th edition.


Subcutaneous Disorder

description: A disorder of the subcutaneous tissue.


name: Undersocialized conduct disorder, aggressive type


name: Locally Advanced Biliary Tract Carcinoma

description: Carcinoma that arises from the intrahepatic, hilar, extrahepatic bile ducts, cystic duct, or gallbladder and has spread to nearby tissues or lymph nodes.


name: Radiating Chest Pain Along Left Midclavicular Line

description: The location of the radiating chest pain is along the left midclavicular line.


name: Refractory Endometrial Transitional Cell Carcinoma

description: Endometrial transitional cell carcinoma that is resistant to treatment.


Recurrent Appendix Carcinoma

description: The reemergence of appendix carcinoma after a period of remission.


Kidney Schwannoma

description: A rare schwannoma arising from the kidney.


Childhood Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that occurs during childhood.


Congenital complete heart block

description: A disorder characterized by an electrocardiographic finding of a complete atrioventricular block that manifests during fetal life or soon after birth. It may be isolated or associated with other congenital heart defects. Isolated congenital complete atrioventricular block may be associated with maternal connective tissue disorders.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 2

description: Dyskeratosis congenita caused by mutation(s) in the TERT gene, encoding telomerase reverse transcriptase.


name: Appendix Neuroendocrine Tumor by AJCC v7 Stage

description: A term that refers to the staging of an appendiceal neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system.


name: Lugano Classification Stage IE Childhood Hodgkin Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Metaplastic meningioma

description: A WHO grade I meningioma characterized by the presence of a prominent mesenchymal component. The mesenchymal component may be osseous, cartilaginous, myxoid, lipomatous, or a mixture of mesenchymal elements.


name: Postneoadjuvant Therapy Stage IVA Esophageal Adenocarcinoma AJCC v8

description: Stage IVA includes: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Stage IV Bone Cancer AJCC v7

description: Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Childhood Blue Nevus

description: A blue nevus that occurs during childhood.


Joint Tuberculosis

description: Tuberculosis affecting a joint.


Ureter Cancer by AJCC v7 Stage

description: A term that refers to the staging of ureter cancer according to the American Joint Committee on Cancer, 7th edition.


Foregut Neuroendocrine Tumor G1

description: A neuroendocrine tumor that arises from the esophagus, stomach, or duodenum.


Radiating Chest Pain in Left Arm

description: The location of the radiating chest pain is in the left arm.


Stage IIIA Gallbladder Cancer AJCC v7

description: Stage IIIA includes: T3, N0, M0. T3: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Polycythaemia (excl rubra vera)

description: An increase in the concentration of red blood cells (hemoglobin) that is not caused by polycythemia vera.


name: Stage IIIC Uterine Corpus Cancer AJCC v8

description: Stage IIIC includes: IIIC1: T1-T3, N1/N1mi/N1a, M0; IIIC2: T1-T3, N2/N2mi/N2a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N1: Regional lymph node metastasis to pelvic lymph nodes. N1mi: Regional lymph node metastasis (greater than 0.2 mm but nor greater than 2.0 mm in diameter) to pelvic lymph nodes. N1a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2mi: Regional lymph node metastasis (greater than 0.2 mm but not greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


description: Thrombotic microangiopathy that presents in some patients undergoing hematopoietic stem cell transplantation (HSCT). Though similar in presentation to thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS), transplant-associated thrombotic microangiopathy (TA-TMA) is a distinct disorder. Several risk factors may be associated with TA-TMA, including high-dose chemotherapy, radiation therapy, HLA mismatch, use of calcineurin inhibitors, acute graft-versus-host disease (GVHD), and infections.


Corneal dellen

description: Corneal thinning just anterior to the limbus secondary to abnormal and/or irregular bulbar conjunctival contour.


name: Chest Pain in Left Fourth Intercostal Space

description: The location of the chest pain is within the fourth intercostal space on the left side.


Spindle cell melanoma, type B

description: A melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli. Representative example is the type B spindle cell uveal melanoma.


name: Esophageal Adenocarcinoma by AJCC v8 Stage

description: A term that refers to the staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


name: asymptomatic carrier of alpha-thalassemia

description: A condition in which a person has reduced protein production from one of the four alpha-globin alleles.


Stage IIIC Cervical Cancer FIGO 2018

description: Cervical carcinoma with involvement of pelvic and/or para-aortic lymph nodes, irrespective of tumor size and extent (with r and p notations). (FIGO 2018)


Recurrent Severe Aplastic Anemia

description: The reemergence of severe aplastic anemia after a period of remission.


name: Recurrent Pancreatic Neuroendocrine Carcinoma

description: The reemergence of pancreatic neuroendocrine carcinoma after a period of remission.


Stage II Cervical Cancer FIGO 2018

description: The cervical carcinoma invades beyond the uterus, but has not extended onto the lower third of the vagina or to the pelvic wall. (FIGO 2018)


Low Grade Osteosarcoma

description: An osteosarcoma with low-grade morphological features. This category includes parosteal osteosarcoma and low-grade central osteosarcoma.


Obstructed femoral hernia

description: The protrusion of contents of the abdominal cavity, into the femoral canal, which results in obstruction of intestinal peristalsis.


description: Tuberculosis disease that is caused by a pre-extensively drug-resistant strain of Mycobacterium tuberculosis.


Non-Neoplastic Pancreatic Disorder

description: A non-neoplastic disorder that affects the pancreas. Representative examples include pancreatitis and pancreatic insufficiency.


Sporadic Gastric Diffuse Adenocarcinoma

description: A sporadic adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of poorly cohesive malignant cells and absence of glandular formations.


Cesarean Scar Pregnancy

description: An ectopic pregnancy implanted in a previous cesarean (hysterotomy) scar, surrounded by myometrium and connective tissue.


Kir6.2-Associated Diabetes Mellitus

description: Diabetes mellitus caused by activating mutation(s) in the KCNJ11 gene, encoding the inwardly rectifying Kir6.2 subunit of the pancreatic beta cell adenosine triphosphate-sensitive potassium channel. Note: Inactivating mutation(s) in the KCNJ11 gene result in hyperinsulinism.


Congenital neuropathy

description: Neuropathy, the cause of which is present at birth.


Recurrent Ureter Carcinoma

description: The reemergence of ureter carcinoma after a period of remission


Cystitis Cystica and Glandularis

description: A reactive inflammatory disorder affecting the bladder.  It is characterized by the development of small cysts in the bladder wall.  The cysts are lined by urothelial cells and metaplastic glandular cells.


Non-Neoplastic Gallbladder Disorder

description: A non-neoplastic disorder that affects the gallbladder. Representative examples include cholecystitis and adenomyomatosis.


name: Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type

description: An X-linked recessive condition caused by mutation(s) in the UBE2A gene, encoding ubiquitin-conjugating enzyme E2 A. It is characterized by facial dysmorphisms and intellectual impairment.


name: Malignant Peripheral Nerve Sheath Tumor with Mesenchymal Differentiation

description: A malignant peripheral nerve sheath tumor characterized by the presence of mesenchymal differentiation.  Representative example is the malignant Triton tumor which contains a rhabdomyosarcomatous component.


name: Non-Inflammatory Female Reproductive System Disorder

description: A non-inflammatory disorder that affects the female reproductive system.


Bisphosphonate-associated osteonecrosis

description: Necrosis of the mandible or maxilla in patients receiving intravenous or oral bisphosphonate therapy.  It usually manifests with slow healing or failure to heal of a jaw bone following oral surgery.  In a minority of cases, the necrosis appears spontaneously.  Signs and symptoms include pain, swelling and infection of the affected area.


Benign Extragonadal Germ Cell Tumor

description: A germ cell tumor that arises from an anatomic site other than the testis or ovary. There is no evidence of atypia or metastases.


name: Unspecified nonpsychotic mental disorder following organic brain damage

description: Any mental disorder that occurs secondary to organic brain damage, and that is not associated with psychosis.


name: Refractory Endometrial Squamous Cell Carcinoma

description: Endometrial transitional cell carcinoma that is resistant to treatment.


name: Kidney Mixed Epithelial and Stromal Tumor Family

description: A family of tumors ranging from predominantly cystic tumors (adult cystic nephromas) to tumors that are variably solid (mixed epithelial and stromal tumors) and contain biphasic epithelial and stromal components with spindle stroma, glands, and cysts. Most of these tumors are benign. (WHO 2016).


description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the skin.


Refractory Pancreatic Adenocarcinoma

description: Pancreatic adenocarcinoma that is resistant to treatment.


name: Nodular Sclerosis Classic Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for nodular sclerosis classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Cervical Meningocele

description: A congenital abnormality in the cervical region of the spine in which the meninges protrude through a defect in the spinal column.


Primary Cold Agglutinin Disease

description: A clonal B-cell lymphoproliferative disease of the bone marrow that results in autoimmune hemolytic anemia. It is distinct from lymphoplasmacytic lymphoma and IgM monoclonal gammopathy of undetermined significance. It lacks MYD88 gene mutation and is associated with trisomies of chromosomes 3, 12, and 18, and mutations in KMT2D and CARD11 genes.


name: Recurrent High Grade Endometrioid Adenocarcinoma

description: The reemergence of high-grade endometrioid adenocarcinoma after a period of remission.


name: Acute Myeloid Leukemia with t(11;17)(q23;q21); ZBTB16-RARA

description: Acute myeloid leukemia with the variant RARA t(11;17)(q23;q21) and the expression of ZBTB16-RARA fusion protein.  It lacks differentiation response to retinoids treatment.


Pressure Chest Pain

description: The sensation of chest pain described as an object creating physical force.


Advanced cancer

description: A malignant neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Dermal Spitz Nevus

description: A Spitz nevus characterized by the presence of an intradermal melanocytic component without junctional melanocytic activity.


Borderline Paratesticular Serous Tumor

description: A rare, non-invasive, serous cystic tumor that arises from the paratesticular structures. It is characterized by the presence of irregular papillary formations with irregular branching. The papillae are lined by atypical columnar epithelial cells with eosinophilic cytoplasm. Mitoses are rare. Metastases have not been reported.


name: Adult Nodular Sclerosis Classical Hodgkin Lymphoma

description: Nodular sclerosis classic Hodgkin lymphoma occurring in adults.


Chronic Myelomonocytic Leukemia-0

description: A chronic myelomonocytic leukemia characterized by the presence of less than 5 percent blasts in the bone marrow and less than 2 percent blasts in the peripheral blood.


Trichoblastic carcinoma

description: A rare biphasic malignant neoplasm with dual differentiation towards the specialized follicular stroma and germinative follicular cells, which can be strikingly atypical. (WHO 2018)


name: Acute Myeloid Leukemia with t(11;19)(q23.3;p13.1); KMT2A-ELL

description: An acute myeloid leukemia associated with t(11;19)(q23.3;p13.1) resulting in KMT2A-ELL gene fusion.


Shooting Pain

description: An intense sensation of discomfort or distress that radiates from one location to another sharply.


name: Stage IB Pancreatic Cancer AJCC v6 and v7

description: Stage IB includes: T2, N0, M0. T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Acute Myeloid Leukemia with t(10;11)(q21.3;q23.3); TET1-KMT2A

description: An acute myeloid leukemia associated with t(10;11)(q21.3;q23.3) resulting in TET1-KMT2A gene fusion.


Pre-Malignant Skin Epithelial Lesion

description: A term that refers to precancerous epithelial pathologic processes that affect the skin.


name: Reactive lymphoid hyperplasia of lacrimal gland

description: A polyclonal proliferation of lymphoid tissue in the lacrimal gland. It usually presents as painless palpable masses leading to globe displacement, decreased motility, diplopia, and ptosis. It has a tendency to involve bilateral lacrimal glands. There is a higher incidence in females and in the setting of autoimmune disease. (WHO 2018)


Sign or Symptom

description: Objective evidence of disease perceptible to the examining practitioner (sign) and subjective evidence of disease perceived by the patient (symptom).


Paraphrenia

description: A form of schizophrenia characterized by delusions (of persecution or grandeur or jealousy); symptoms may include anger and anxiety and aloofness and doubts about gender identity; unlike other types of schizophrenia the patients are usually presentable and (if delusions are not acted on) may function in an apparently normal manner.


name: Asymptomatic human immunodeficiency virus infection

description: An infection caused by human immunodeficiency virus (HIV) that is asymptomatic at the time of testing.


name: 21-hydroxylase deficiency - simple virilizing

description: A classic form of congenital adrenal hyperplasia that is characterized by severe 21-hydroxylase deficiency, resulting in glucocorticoid and mineralocorticoid deficiency, but without clinically significant salt wasting, and with androgen excess, which causes virilization in female infants.


name: PERSISTENT MULLERIAN DUCT SYNDROME, TYPE I

description: Persistent Mullerian duct syndrome due to deficiency of anti-Mullerian hormone.


Recurrent Cervical Adenocarcinoma

description: The reemergence of cervical adenocarcinoma after a period of remission.


Chronic diastolic heart failure

description: Chronic congestive heart failure due to a left ventricle which does not fill properly due to decreased compliance though the ejection fraction may be preserved.


name: Non-Invasive Pancreatic Mucinous-Cystic Neoplasm

description: A cystic epithelial neoplasm that arises from the pancreas and is characterized by the presence of columnar mucin-producing epithelial cells, ovarian-type stroma formation, and the absence of an invasive carcinomatous component.


Refractory Malignant Lymphoid Neoplasm

description: A malignant lymphoid neoplasm that does not respond to treatment.


Splenic thrombosis

description: Formation of a blood clot (thrombus) in the lumen of the splenic vein or splenic artery.


Stage I Osteosarcoma AJCC v7

description: Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Combined BAP1-inactivated melanocytoma

description: A BAP1-inactivated melanocytoma that is combined with a smaller area of melanocytic proliferation in the basal layer of the epidermis.


Acne aggravated

description: A flare of acne which may be precipitated by variety of factors, including hormonal activity, stress, oils and oily cosmetics, sweat, overwashing, and certain foods and drugs.


Malignant glioma of brain

description: A grade 3 or 4 glioma that arises from the brain. This category includes anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligoastrocytoma, anaplastic oligodendroglioma, anaplastic pleomorphic xanthoastrocytoma (all grade 3 gliomas), and glioblastoma (grade 4 glioma).


name: Adenocarcinoma in situ in adenomatous polyp

description: A non-invasive adenocarcinoma arising from the neoplastic glandular cells in an adenomatous polyp.


Pseudoepitheliomatous hyperplasia

description: A benign lesion characterized by epidermal and adnexal epithelial hyperplasia.  It is caused by chronic inflammation and infection.  It may be associated with cutaneous neoplasms as well.


name: Cervical Squamous Intraepithelial Neoplasia 1

description: Cervical squamous intraepithelial neoplasia characterized by the presence of maturation in the upper two-thirds of the squamous epithelium and mild nuclear atypia which is present in all epithelial layers.  Mitotic figures are present in the basal third of the epithelium.


Cerebral Hemangioblastoma

description: A hemangioblastoma that arises from the cerebrum.


Recurrent Intracranial Neoplasm

description: The reemergence of an intracranial neoplasm after a period of remission.


Stage IIIB Cervical Cancer FIGO 2009

description: Cervical carcinoma involving the pelvic sidewall. (FIGO 2009)


Non-Neoplastic Eye Disorder

description: A non-neoplastic disorder that affects the eye.


description: Esophageal adenocarcinoma that has metastasized to a limited number of sites.


name: New Onset Atrial Fibrillation Related to COVID-19

description: Newly occurring atrial fibrillation (AF) in a patient with probable or confirmed acute COVID-19. It is further categorized as first detected AF, paroxysmal AF (self-terminating within seven days of recognized onset), or persistent AF (not self-terminating within seven days).


Blood and lymphatic system disorders

description: A non-neoplastic or neoplastic disorder that affects the hematopoietic and lymphatic system.


Metastatic Cervical Carcinoma

description: A carcinoma of the cervix that has spread to another anatomic site.


Symptom

description: Subjective evidence of disease perceived by the patient.


name: MYOD1-Mutant Spindle Cell/Sclerosing Rhabdomyosarcoma

description: Spindle cell/sclerosing rhabdomyosarcoma characterized by the presence of MYOD1 p.Leu122Arg substitution mutation. This subtype includes most spindle cell/sclerosing rhabdomyosarcomas in adolescents and young adults, as well as some cases in older adults. It follows an aggressive clinical course.


name: Metastatic Bladder Lipid-Rich Urothelial Carcinoma

description: Bladder lipid-rich urothelial carcinoma that has spread to another anatomic site.


name: Hodgkin's disease nodular sclerosis stage II supradiaphragmatic


Refractory Adnexal Carcinoma

description: Adnexal carcinoma that is resistant to treatment.


name: 46,XX/46,XY Ovotesticular Differences of Sex Development

description: Ovotesticular differences of sex development in individuals with 46,XY/46,XX mosaic karyotype.


Elevated Test Result

description: A result of a test that is higher than a previous value or a normal range of values.


Gingival Pain

description: Painful sensation in the gingival region.


Acute Pericarditis Related to COVID-19

description: Acute pericarditis in a patient with probable or confirmed acute COVID-19.


name: Low Grade Esophageal Glandular Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal glandular epithelium.


Cryptococcal gastroenteritis

description: Gastroenteritis resulting from an infection with cryptosporidium.


Grade 1 Dysphasia, CTCAE

description: Awareness of receptive or expressive characteristics; not impairing ability to communicate


Unresectable Gastric Carcinoma

description: A gastric carcinoma that is not amenable to surgical resection.


name: Recurrent Fallopian Tube Endometrioid Adenocarcinoma

description: The reemergence of fallopian tube endometrioid adenocarcinoma after a period of remission.


Gnathoschisis

description: A congenital abnormality consisting of clefting in the jaw, which results from incomplete fusion of the embryonic mandibular prominence.


Non-Neoplastic Bone Disorder

description: A non-neoplastic disorder that affects the bone or articular cartilage.


Adult Ganglioneuroma

description: A ganglioneuroma that occurs in adults.


Nonerosive Arthritis

description: An inflammation of one or more joints, without loss of articular cartilage or destruction of subchondral bone.


name: Complete Atrioventricular Septal Defect with Tetralogy of Fallot

description: A rare congenital heart anomaly in which there is coexistence of tetralogy of Fallot and complete atrioventricular septal defect. The latter is characterized by defects in the atrial and ventricular septa and a common atrioventricular valve.


name: Gallbladder Adenocarcinoma, Biliary Type

description: A well or moderately differentiated adenocarcinoma that arises from the gallbladder.  It is the most common type of gallbladder carcinoma and is characterized by the presence of malignant tubular glands.  Intestinal differentiation may be present.


Locally Advanced Unresectable Sarcoma

description: A sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Recurrent Low Grade Glioma

description: The reemergence of low grade glioma after a period of remission.


name: Non-Neoplastic Endocrine Pancreas Disorder

description: A non-neoplastic disorder that affects the endocrine pancreas.


name: Invasive Urothelial Carcinoma with Squamous Differentiation

description: An invasive urothelial carcinoma that exhibits squamous differentiation.


Chest Pain in Intercostal Space

description: The location of the chest pain is in the area defined by a superior rib margin and an inferior rib margin.


Lip Infection

description: An acute or chronic infectious process affecting the lips.


name: Endometrioid Adenocarcinoma of the Urinary Tract

description: An exceptionally rare endometrioid adenocarcinoma that arises from the urinary tract. It occurs in middle-aged and elderly females. It is associated with genitourinary endometriosis and has been described in the bladder and ureter.


Brain Development Abnormality

description: A group of congenital or acquired disorders that affect the normal development of the brain.


name: Invasive Micropapillary Urothelial Carcinoma

description: Invasive urothelial carcinoma exhibiting micropapillary growth pattern.


Allergic arthritis

description: Arthritis occurring after the ingestion of allergenic substance(s).


name: Severe Gastrointestinal Tract Acute Graft Versus Host Disease

description: Graft versus host disease occurring in the gastrointestinal tract and is characterized by complications that may be life-threatening.


name: Pathologic Stage I Retinoblastoma AJCC v8

description: Stage I includes: pT1, pT2, pT3, pN0, cM0, Any H. pT1: Intraocular tumor(s) without any local invasion, focal choroidal invasion, or pre-or intralaminar involvement of the optic nerve head. pT2: Intraocular tumor(s) with local invasion. pT3: Intraocular tumor(s) with significant local invasion. pN0: No lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


name: Lacrimal Drainage System Non-Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma of the lacrimal drainage system characterized by a plexiform or ribbon-like growth pattern, cytological atypia, and lack of histological evidence of keratinization.


Refractory Urinary System Carcinoma

description: Urinary system carcinoma that does not respond to treatment.


name: Recurrent Malignant Male Reproductive System Neoplasm

description: The reemergence of a malignant male reproductive system neoplasm after a period of remission.


name: Invasive Bladder Urothelial Carcinoma with Squamous Differentiation

description: An invasive urothelial carcinoma of the bladder that exhibits squamous differentiation.


name: Mixed Phenotype Acute Leukemia, T/Megakaryocytic

description: A very rare mixed phenotype acute leukemia in which the blasts show evidence of T-cell and megakaryocytic lineage but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation.


Conjunctival Melanoma In Situ

description: A term that refers to conjunctival melanocytic intraepithelial lesions with severe atypia involving close to full thickness of the epithelium or lesions with histologic characteristics of melanoma that lack documented evidence of subepithelial invasion.


Clinical Stage I Retinoblastoma AJCC v8

description: Stage I includes: cT1, cT2, cT3, cN0, cM0, Any H. cT1: Intraretinal tumor(s) with subretinal fluid 5 mm or less from the base of any tumor. cT2: Intraocular tumor(s) with retinal detachment, vitreous seeding, or subretinal seeding. cT3: Advanced intraocular tumor(s). cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Papillary serous cystadenoma

description: A serous benign or low malignant potential cystic epithelial neoplasm characterized by the presence of glandular epithelial cells forming papillary structures.


name: Steroid Resistant Acute Graft Versus Host Disease

description: Acute graft versus host disease that is resistant to treatment with steroids.


name: Fallopian Tube Metaplastic Papillary Tumor

description: A rare metaplastic lesion that arises from the fallopian tube. It is characterized by the presence of an intraluminal papillary proliferation composed of atypical epithelial cells with abundant eosinophilic cytoplasm. In the vast majority of cases, it is an incidental finding during microscopic examination of a fallopian tube in the postpartum period.


Malignant Solid Neoplasm

description: A malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include carcinomas and sarcomas. Hematopoietic and lymphoid tissue malignancies are not considered solid neoplasms.


Recurrent Fallopian Tube Carcinoma

description: The reemergence of fallopian tube carcinoma after a period of remission.


name: Non-Neoplastic Disorder by Special Category


ROSE Cluster 1

description: Gene expression cluster 1 as determined by Recognition of Outliers by Sampling Ends (ROSE) in high-risk B-precursor acute lymphoblastic leukemia.


Recurrent Nervous System Neoplasm

description: The reemergence of a nervous system neoplasm after a period of remission.


Obstruction

description: Blockage of the normal flow of the contents of an anatomical passageway.


name: Refractory T-Cell Large Granular Lymphocyte Leukemia

description: T-cell large granular lymphocyte leukemia that is resistant to treatment.


Hereditary Malignant Neoplasm

description: Malignant neoplasms occurring in families at a rate greater than that expected by chance and caused by germline mutations in a specific gene.


Occlusion of inferior vena cava

description: Blockage of the lumen of the inferior vena cava.


name: Lugano Classification Advanced Stage Adult Lymphoma AJCC v8

description: Advanced stage adult lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


Monogenic Hyperinsulinism

description: A genetically heterogenous group of hyperinsulinemic conditions caused by mutation(s) in one of the many genes involved in the regulation of insulin secretion.


Cervix carcinoma recurrent

description: The reemergence of cervical carcinoma after a period of remission.


Cancer of Urinary Tract

description: A primary or metastatic malignant neoplasm involving the urinary tract.


Ectopic ureter

description: A congenital anomaly in which the ureteral orifice drains into an abnormal location.


Advanced Rare Malignant Solid Neoplasm

description: A rare malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Endometrial Endometrioid Adenocarcinoma with Clear Cell Change

description: A morphologic variant of endometrioid adenocarcinoma characterized by the presence of large multinucleated clear cells.


name: Extended Oligoarticular Juvenile Idiopathic Arthritis

description: Oligoarticular juvenile idiopathic arthritis that eventually involves more than four separate joints.


name: Staphylococcal arthritis and polyarthritis


name: Intellectual Disability, Autosomal Dominant 4

description: An autosomal dominant condition caused by mutation(s) in the CHAMP1 gene, encoding chromosome alignment-maintaining phosphoprotein 1. It is characterized by moderate to severe intellectual disability with poor speech acquisition. Variable dysmorphic features may be present as well.


Neoplasm of lacrimal drainage system

description: A benign or malignant neoplasm that affects the lacrimal drainage system.


Ovarian Infection

description: An infectious process affecting the ovary.


name: Invasive Urothelial Carcinoma with Trophoblastic Differentiation

description: An invasive urothelial carcinoma characterized by the presence of trophoblastic differentiation.


Occupational Malignant Neoplasm

description: Malignant neoplasm secondary to occupational exposure to carcinogens.


Neuroendocrine cervical carcinoma

description: A malignant, high grade neuroendocrine neoplasm that arises from the cervix. This category includes small cell and large cell neuroendocrine carcinoma.


Acute Stroke Related to COVID-19

description: The sudden or severe onset of neurological deficit(s) attributable to an acute focal vascular injury of the central nervous system in a patient with probable or confirmed acute COVID-19.


Supratentorial Meningioma

description: A meningioma that affects the supratentorial brain.


name: Stage IIC Fallopian Tube Cancer AJCC v6 and v7

description: Stage IIC includes: T2c, N0, M0.  T2c: Pelvic extension with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Low grade appendiceal mucinous neoplasm

description: A well differentiated mucinous neoplasm that arises from the appendix.  It is characterized by slow growth and it is associated with the development of pseudomyxoma peritonei.


Genitourinary System Neoplasm

description: A benign or malignant neoplasm that affects the genitourinary system.


Urethral Cancer by AJCC v8 Stage

description: A term that refers to the staging of urethral cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to urothelial (transitional cell), squamous, and glandular carcinomas of the urethra and to urothelial (transitional cell) carcinomas of the prostate and prostatic urethra. It does not apply to squamous cell carcinomas of the penile foreskin (are staged according to the classification for penis), primary urothelial carcinomas of the bladder with transmural involvement of the prostate (are staged according to the classification for urinary bladder), prostatic adenocarcinomas (are staged according to the classification for prostate), mucosal melanomas of the urethra (no AJCC staging system), lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and sarcomas (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs).  (from AJCC 8th Ed.)


Diffuse Non-Pontine Midline Glioma

description: A diffuse glioma that arises from the midline structures of the central nervous system, other than the pons.


name: Cerebral Venous Thrombosis Related to COVID-19


Perihepatic abscess

description: An abscess that is located in the anatomical space surrounding the liver, but which is outside of the liver capsule itself.


name: Recurrent Fallopian Tube Clear Cell Adenocarcinoma

description: The reemergence of fallopian tube clear cell adenocarcinoma after a period of remission.


name: Vaginal Mucinous Adenocarcinoma, Intestinal-Type

description: A vaginal mucinous adenocarcinoma that resembles a large intestinal adenocarcinoma.


Meningeal Leukemia

description: Infiltration of the meninges by an acute or chronic leukemia.


Locally Advanced Malignant Mesothelioma

description: Malignant mesothelioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Acquired hydrocephalus

description: Hydrocephalus that results from head trauma, brain tumors, intracranial hemorrhage, or meningitis.


name: Recurrent Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: The reemergence of undifferentiated high grade pleomorphic sarcoma of bone in childhood after a period of remission.


name: Refractory Adult Acute Lymphoblastic Leukemia

description: Acute lymphoblastic leukemia that occurs in adulthood and does not respond to treatment.


Pigmented Actinic Keratosis

description: Actinic keratosis characterized by the presence of increased melanin pigmentation in the basal keratinocytes.


name: Metastatic Childhood Retinoblastoma by Toronto Guidelines v2

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Myxoid pleomorphic liposarcoma

description: An exceptionally rare, aggressive adipocytic neoplasm, typically occurring in children and adolescents. Myxoid pleomorphic liposarcoma shows mixed histological features of conventional myxoid liposarcoma and pleomorphic liposarcoma and lacks the gene fusions and amplifications of myxoid liposarcoma, atypical lipomatous tumor, and dedifferentiated liposarcoma. (WHO 2020)


name: T Acute Lymphoblastic Leukemia with SPI1 Rearrangement

description: T acute lymphoblastic leukemia characterized by the presence of SPI1 gene rearrangement. It has a poor prognosis.


name: Pediatric Non-Congenital Ventricular Tachycardia

description: A disorder characterized by an electrocardiographic finding of three or more consecutive complexes of ventricular origin that was not present at birth in an individual under age 21. The QRS complexes are wide and have an abnormal morphology.


Esophageal carcinoma recurrent

description: An esophageal carcinoma which has reappeared after a period of remission or after presumed treatment.


Stage II Fallopian Tube Cancer

description: Stage II includes: (T2, N0, M0); IIA: (T2a, N0, M0); IIB (T2b, N0, M0); IIC (T2c, N0, M0).  T2: Tumor involves one or both fallopian tubes with pelvic extension.  T2a: Extension and/or metastasis to the uterus and/or ovaries.  T2b: Extension to other pelvic structures.  T2c: Pelvic extension with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IB Cervical Cancer AJCC v6 and v7

description: Stage IB includes: IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Metastatic High Grade Sarcoma

description: High-grade sarcoma that has spread from its original site of growth to another anatomic site.


name: benign granular cell tumor of gallbladder

description: A granular cell tumor that arises from the gallbladder and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Aplastic Anemia due to Hepatitis

description: Bone marrow failure defined as pancytopenia, secondary to hepatitis.


Reticulosarcoma of spleen

description: An antiquated term that refers to a non-Hodgkin lymphoma composed of diffuse infiltrates of large, often anaplastic lymphocytes affecting the spleen.


name: immune effector cell-associated neurotoxicity syndrome, grade 4

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 0 or if the ICE scale cannot be performed (for adults and children over 12), or if the Cornell Assessment of Pediatric Delirium (CAPD) scale cannot be performed (for children 12 and under), the inability of the affected individual to be arousable without vigorous or repetitive tactile stimuli, life-threatening prolonged (greater than 5 minutes) seizures, or repetitive clinical or electroencephalographically-detected seizures without ever returning to baseline, deep focal motor weakness, diffuse cerebral edema evident on neuroimaging, decerebrate or decorticate posturing, cranial nerve VI palsy, papilledema or Cushing's triad (bradycardia, hypertension, respiratory depression).


Cervical Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm arising from the cervix.


name: Ancylostomiasis due to Ancylostoma braziliense (disorder)

description: Infection by Ancylostoma braziliense.


Metastatic Cervical Adenocarcinoma

description: A cervical adenocarcinoma that has spread to another anatomic site.


Refractory Cutaneous Melanoma

description: Melanoma of the skin that is resistant to treatment.


Breast Schwannoma

description: A schwannoma that arises from the breast.


Gastrointestinal disorder congenital

description: An abnormality of the digestive system that is present at birth or detected in the neonatal period.


Structural Heart Abnormality

description: An anatomic deformity of the heart, ventricles or great vessels.


Retinal arteriovenous malformation

description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the retina.


Foreign body granuloma of muscle

description: An inflammatory lesion in the muscle comprised of epithelioid histiocytes and chronic inflammation that is caused by the presence of extraneous material .


name: Refractory Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that is resistant to treatment.


Recurrent EBV-Related Lymphoma

description: The reemergence of EBV-related lymphoma after a period of remission.


Paratesticular Adenomatoid Tumor

description: An adenomatoid tumor arising from the paratesticular structures. It is the most common tumor of the paratesticular region. The tail of the epididymis is the most common site of involvement.


Non-Cardiac Chest Pain

description: Pain in the chest unrelated to a heart disorder.


Pancreatic adenocarcinoma metastatic

description: An adenocarcinoma that arises from the exocrine pancreatic tissue and has metastasized to other anatomic sites.


description: A lymphoproliferative disorder that develops in an individual with HIV infection.


name: Glioneuronal Tumor with Neuropil-Like Islands

description: A rare, WHO grade II or III infiltrating astrocytoma characterized by the presence of sharply demarcated foci, composed of a neuropil-like matrix.


Stage IIIC Esophageal Cancer AJCC v7

description: Stage IIIC includes: For squamous cell carcinoma: (T4a, N1-2, M0, Any G, Tumor location: Any); (T4b, Any N, M0, Any G, Tumor location: Any); (Any T, N3, M0, Any G, Tumor location: Any).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Extrahepatic Bile Duct Neuroendocrine Tumor

description: A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts.


name: Type III Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the common pulmonary vein connects to the portal venous system through the diaphragm.


name: Malignant Outer Hair Sheath and Infundibulum Neoplasm

description: A malignant neoplasm that arises from the outer hair sheath and infundibulum.


Stage IIA Bone Sarcoma AJCC v7

description: Stage IIA includes: T1, N0, M0, G3, G4.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Peripheral Nerve Injuries

description: Sensory or motor loss of peripheral nerve function due to a traumatic event. (ACC)


name: Myopathy Secondary to Glycogen Storage Disorder

description: A myopathy that was caused by a primary disorder of glycogen storage.


Lacrimal Gland Oncocytic Adenocarcinoma

description: An adenocarcinoma that arises from the lacrimal gland. It is characterized by the presence of large malignant epithelial cells with abundant granular eosinophilic cytoplasm.


name: Hodgkin's disease of intrapelvic lymph nodes

description: Stage I Hodgkin lymphoma involving the subdiaphragmatic region.


name: T Acute Lymphoblastic Leukemia, HOXA Dysregulated

description: T acute lymphoblastic leukemia characterized by an ectopic activation of the HOXA genes.


Vulvar Yolk Sac Tumor

description: A rare yolk sac tumor that arises from the vulva.


Bone marrow mastocytosis

description: A variant of indolent systemic mastocytosis that affects predominantly older males. It is characterized by a limited degree of bone marrow infiltration by clonal mast cells and an absence of skin involvement. The serum tryptase levels are normal or slightly elevated.


Radiation retinopathy

description: Injury of the retina following exposure to radiation.  The retinal injury results from occlusive microangiopathy caused by endothelial cell loss.


Stage 0 Vulvar Cancer

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (preinvasive carcinoma). N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


name: Chest Pain in Right Fourth Intercostal Space

description: The location of the chest pain is within the fourth intercostal space on the right side.


Fibroblastic reticular cell neoplasm

description: A very rare dendritic cell sarcoma affecting the lymph nodes, spleen, and soft tissues. Morphologically it is similar to the interdigitating dendritic cell sarcoma or follicular dendritic cell sarcoma. The tumor cells are positive for cytokeratin and CD68.


Bacterial Toxemia

description: The condition resulting from the spread of bacterial products (toxins) by the bloodstream.


Slipped extraocular muscle

description: Weakness of extraocular muscle function as a result of inadequate securing of the muscle to the sclera during strabismus surgery.


name: Stage IIIA1 Fallopian Tube Cancer AJCC v8

description: Stage IIIA1 includes: T1/2, N1, M0. T1: T1: Fallopian tube cancer with tumor limited to fallopian tube(s). T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Adult Acute Myelomonocytic Leukemia

description: An acute myelomonocytic leukemia occurring in adults.


Locally Recurrent Merkel Cell Carcinoma

description: The reemergence of Merkel cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Refractory WHO Grade 4 Glioma

description: A WHO grade 4 glioma that is resistant to treatment.


name: Clinical Stage IIA Cutaneous Melanoma AJCC v8

description: Stage IIA includes: (T2b, N0, M0); (T3a, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Childhood Digestive System Neuroendocrine Tumor

description: A neuroendocrine tumor that arises from the digestive system and occurs during childhood.


name: Deletion of Chromosome 3p Associated Meningioma

description: A meningioma that is associated with deletion of chromosomal arm 3p.


name: Metastatic Peritoneal Malignant Mesothelioma

description: Peritoneal malignant mesothelioma that has spread from its original site of growth to another anatomic site.


name: Prostate Acinar Pseudohyperplastic Adenocarcinoma

description: Acinar prostate adenocarcinoma characterized by the presence of neoplastic large glands that resemble the benign, non-neoplastic prostate glands.


Spermatogenic granuloma

description: A lump of extravasated sperm in the paratesticular region in men who have undergone vasectomy.


Other Finding

description: An additional finding not previously noted.


Microbiology Laboratory Test Result

description: Clinical laboratory test findings associated with detection, identification or quantitation of microorganisms or products derived from them.


description: Malignant neoplasm occurring in immunodeficient patients.


name: Malignant Peripheral Nerve Sheath Tumor of the Skin

description: A malignant peripheral nerve sheath tumor that arises from the skin.


Coronary Venous Dissection

description: A tear within the wall of a coronary vein. (ACC)


Stage IVA Vulvar Cancer AJCC v8

description: Stage IVA includes: (T1-T2, N3, M0); (T3, Any N, M0). T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). T3: Tumor of any size with extension to any of the following: upper/proximal two-thirds of the urethra, upper/proximal two-thirds of the vagina, bladder mucosa, or rectal mucosa; or fixed to pelvic bone. N3: Fixed or ulcerated regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Chondromesenchymal hamartoma of chest wall

description: A rare benign lesion that arises from the rib cage and affects infants.  It results in the formation of a mass which is composed of spindle cells, cartilage, and hemorrhagic cysts.  Surgical resection is usually curative.


name: Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

description: A group of acute myeloid leukemias characterized by recurrent genetic abnormalities, mainly balanced translocations.  (WHO, 2001)


Immunoglobulin deposition disease

description: A mature B-cell neoplasm characterized by the deposition of immunoglobulin in tissues, resulting in impaired organ function. It includes the following entities: primary amyloidosis, heavy chain deposition disease, and light chain deposition disease.


name: Disorder of eye due to diabetes mellitus

description: A group of disorders affecting the eye in patients with diabetes mellitus. It includes cataract, glaucoma, retinopathy, and blindness.


Testicular Cancer by AJCC v8 Stage

description: A term that refers to the staging of testicular cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to postpubertal germ cell tumors of the testis and malignant sex cord-stromal tumors of the testis. It does not apply to spermatocytic tumors (no AJCC staging system), nonmalignant sex cord-/gonadal -stromal tumors (no AJCC staging system), prepubertal germ cell tumors (no AJCC staging system), hematolymphoid tumors (hematologic malignancies staging system), and paratesticular neoplasms (no AJCC staging system).  (from AJCC 8th Ed.)


Refractory Appendix Adenocarcinoma

description: Appendix adenocarcinoma that is resistant to treatment.


Second Primary Cancers

description: A primary malignant neoplasm in a patient who has been already diagnosed with a primary malignant neoplasm in another anatomic site.


name: Solar Radiation-Related Cutaneous Melanoma

description: Cutaneous melanoma that arises following exposure to solar radiation.


Stage II Vulva Cancer AJCC v6

description: Stage II includes: T2, N0, M0.  T2: Tumor confined to the vulva or vulva and perineum, more than 2cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.)


Thrombocytopenia 5

description: An autosomal dominant disorder characterized by decreased platelets, bleeding tendency, and mutation in the ETV6 gene. It is associated with an increased risk of developing hematologic malignancy.


Silicon granuloma

description: A granuloma that forms in response to silicone exposure.


Stage IVA Cervical Cancer AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Tumor invading the mucosa of the bladder or rectum, and/or extending beyond the true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (from AJCC 8th Ed.)