histamine

A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.


alveolar rhabdomyosarcoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A rapidly growing malignant mesenchymal neoplasm. It is characterized by the presence of round cells with myoblastic differentiation and a fibrovascular stroma resembling an alveolar growth pattern. The tumor usually presents in the extremities.


neuroleptic malignant syndrome

description: Neuroleptic malignant syndrome (NMS) is an idiosyncratic condition associated with administration of antipsychotic and other central dopaminergic blockers, and characterized by hyperthermia, muscular rigidity, autonomic dysfunction and altered consciousness.


name: PKHO1_HUMAN Pleckstrin homology domain-containing family O member 1 (sprot)

description: A pleckstrin homology domain-containing family O member 1 that is encoded in the genome of human.


name: BMP2_HUMAN Bone morphogenetic protein 2 (sprot)

description: A bone morphogenetic protein 2 that is encoded in the genome of human.


name: GLU2B_HUMAN Glucosidase 2 subunit beta (sprot)

description: A glucosidase 2 subunit beta that is encoded in the genome of human.


NEO1_HUMAN Neogenin (sprot)

A neogenin that is encoded in the genome of human.


febuxostat

A 1,3-thiazolemonocarboxylic acid that is 4-methyl-1,3-thiazole-5-carboxylic acid which is substituted by a 3-cyano-4-(2-methylpropoxy)phenyl group at position 2. It is an orally-active, potent, and selective xanthine oxidase inhibitor used for the treatment of chronic hyperuricaemia in patients with gout.


WNT8B_HUMAN Protein Wnt-8b (sprot)

A protein Wnt-8b that is encoded in the genome of human.


WNT11_HUMAN Protein Wnt-11 (sprot)

A protein Wnt-11 that is encoded in the genome of human.


PLEK2_HUMAN Pleckstrin-2 (sprot)

A pleckstrin-2 that is encoded in the genome of human.


name: EPCR_HUMAN Endothelial protein C receptor (sprot)

description: An endothelial protein C receptor that is encoded in the genome of human.


phosphatidylcholine (15:0/16:1)

A phosphatidylcholine 31:1 in which the fatty acyl groups at positions 1 and 2 are specified as C15:0 and C16:1 respectively.


Hyperchloremic metabolic acidosis

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A form of metabolic acidosis with increased serum chloride levels.


name: AAPK1_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-1 (sprot)

description: A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that is encoded in the genome of human.


name: EMX1_HUMAN Homeobox protein EMX1 (sprot)

description: A homeobox protein EMX1 that is encoded in the genome of human.


name: TFE3_HUMAN Transcription factor E3 (sprot)

description: A transcription factor E3 that is encoded in the genome of human.


name: VATB2_HUMAN V-type proton ATPase subunit B, brain isoform (sprot)

description: A V-type proton ATPase subunit B, brain isoform that is encoded in the genome of human.


mepacrine

A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.


name: benign concentric annular macular dystrophy

description: Benign concentric annular macular dystrophy (BCAMD) is a progressive autosomal dominant macular dystrophy characterized by parafoveal hypopigmentation followed by a retinitis pigmentosa-like phenotype (nyctalopia and peripheral vision loss) with a bullBs eye configuration.


Insulin resistance

description: Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels.


nitrogen

An elemental molecule consisting of two trivalently-bonded nitrogen atoms.


name: FLRT3_HUMAN Leucine-rich repeat transmembrane protein FLRT3 (sprot)

description: A leucine-rich repeat transmembrane protein FLRT3 that is encoded in the genome of human.


name: FLRT2_HUMAN Leucine-rich repeat transmembrane protein FLRT2 (sprot)

description: A leucine-rich repeat transmembrane protein FLRT2 that is encoded in the genome of human.


METHAMPHETAMINE HYDROCHLORIDE

A hydrochloride having methamphetamine as the base component.


name: MYPR_HUMAN Myelin proteolipid protein (sprot)

description: A myelin proteolipid protein that is encoded in the genome of human.


WNT3_HUMAN Proto-oncogene Wnt-3 (sprot)

A proto-oncogene Wnt-3 that is encoded in the genome of human.


name: S5A1_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (sprot)

description: A 3-oxo-5-alpha-steroid 4-dehydrogenase 1 that is encoded in the genome of human.


carbimazole

A member of the class of imidazoles that is methimazole in which the nitrogen bearing a hydrogen is converted into its ethoxycarbonyl derivative. A prodrug for methimazol, carbimazole is used for the treatment of hyperthyroidism.


Graves disease

description: Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy, antithyroid drugs, and/or thyroid surgery.


name: GATA3_HUMAN Trans-acting T-cell-specific transcription factor GATA-3 (sprot)

description: A trans-acting T-cell-specific transcription factor GATA-3 that is encoded in the genome of human.


female infertility

description: Diminished or absent ability of a female to achieve conception.


name: SYPL1_HUMAN Synaptophysin-like protein 1 (sprot)

description: A synaptophysin-like protein 1 that is encoded in the genome of human.


name: SP7_HUMAN Transcription factor Sp7 (sprot)

description: A transcription factor Sp7 that is encoded in the genome of human.


collecting duct carcinoma

description: A carcinoma that arises from epithelial cells of the collecting duct of renal tubule


name: STAT6_HUMAN Signal transducer and activator of transcription 6 (sprot)

description: A signal transducer and activator of transcription 6 that is encoded in the genome of human.


name: FOXP3_HUMAN Forkhead box protein P3 (sprot)

description: A forkhead box protein P3 that is encoded in the genome of human.


name: FOXO3_HUMAN Forkhead box protein O3 (sprot)

description: A forkhead box protein O3 that is encoded in the genome of human.


neutropenia

description: A decrease in the number of neutrophils found in the blood.


name: EHMT1_HUMAN Histone-lysine N-methyltransferase EHMT1 (sprot)

description: A histone-lysine N-methyltransferase, H3 lysine-9 specific 5 that is encoded in the genome of human.


name: SL9A8_HUMAN Sodium/hydrogen exchanger 8 (sprot)

description: A sodium/hydrogen exchanger 8 that is encoded in the genome of human.


penciclovir

A member of the class of 2-aminopurines that is guanine in which the hydrogen at position 9 is substituted by a 4-hydroxy-3-(hydroxymethyl)but-1-yl group. An antiviral drug, it is administered topically for treatment of herpes labialis. A prodrug, famciclovir, is used for oral administration.


name: PTC1_HUMAN Protein patched homolog 1 (sprot)

description: A protein patched homolog 1 that is encoded in the genome of human.


H2AX_HUMAN Histone H2AX (sprot)

A histone H2AX that is encoded in the genome of human.


name: EGFL7_HUMAN Epidermal growth factor-like protein 7 (sprot)

description: An epidermal growth factor-like protein 7 that is encoded in the genome of human.


ADML_HUMAN Pro-adrenomedullin (sprot)

A pro-adrenomedullin that is encoded in the genome of human.


name: ERRFI_HUMAN ERBB receptor feedback inhibitor 1 (sprot)

description: An ERBB receptor feedback inhibitor 1 that is encoded in the genome of human.


liver disorder

description: A disease involving the liver.


name: NDUA2_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 that is encoded in the genome of human.


description: An autoimmune demyelinating disease of the central nervous system that is produced experimentally in animals by the injection of homogenized brain or spinal cord in Freund's adjuvant. Myelin basic protein appears to be the antigen that elicits the hypersensitivity immune response which is characterized by focal areas of lymphocyte and macrophage infiltration into the brain, associated with demyelination and destruction of the blood-brain barrier. Experimental allergic encephalomyelitis (EAE) is used as an animal model for demyelinating diseases of the human central nervous system such as multiple sclerosis.


subependymal giant cell astrocytoma

description: A benign, slowly growing tumor (WHO grade I) typically arising in the wall of the lateral ventricles and composed of large ganglioid astrocytes. It is the most common CNS neoplasm in patients with tuberous sclerosis complex and typically occurs during the first two decades of life. (WHO)


name: PITX1_HUMAN Pituitary homeobox 1 (sprot)

description: A pituitary homeobox 1 that is encoded in the genome of human.


sulfapyridine

A sulfonamide consisting of pyridine with a 4-aminobenzenesulfonamido group at the 2-position.


name: IL1FA_HUMAN Interleukin-1 family member 10 (sprot)

description: An interleukin-1 family member 10 that is encoded in the genome of human.


name: ADA1D_HUMAN Alpha-1D adrenergic receptor (sprot)

description: An alpha-1D adrenergic receptor that is encoded in the genome of human.


tannic acid

A gallotannin obtained by acylation of the five hydroxy groups of D-glucose by 3,4-dihydroxy-5-[(3,4,5-trihydroxybenzoyl)oxy]benzoic acid (a gallic acid dimer).


name: HDAC4_HUMAN Histone deacetylase 4 (sprot)

description: A histone deacetylase 4 that is encoded in the genome of human.


name: RSF1_HUMAN Remodeling and spacing factor 1 (sprot)

description: A remodeling and spacing factor 1 that is encoded in the genome of human.


name: CENPS_HUMAN Centromere protein S (sprot)

description: A centromere protein S that is encoded in the genome of human.


cholic acid

A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.


name: KCNH4_HUMAN Potassium voltage-gated channel subfamily H member 4 (sprot)

description: A voltage-gated potassium channel KCNH4 that is encoded in the genome of human.


ERGOSTEROL

A phytosterol consisting of ergostane having double bonds at the 5,6-, 7,8- and 22,23-positions as well as a 3beta-hydroxy group.


name: TRPC1_HUMAN Short transient receptor potential channel 1 (sprot)

description: A short transient receptor potential channel 1 that is encoded in the genome of human.


name: CCR4_HUMAN C-C chemokine receptor type 4 (sprot)

description: A C-C chemokine receptor type 4 that is encoded in the genome of human.


name: SO4C1_HUMAN Solute carrier organic anion transporter family member 4C1 (sprot)

description: A solute carrier organic anion transporter family member 4C1 that is encoded in the genome of human.


isopropyl beta-D-thiogalactopyranoside

An S-glycosyl compound consisting of beta-D-1-thiogalactose having an isopropyl group attached to the anomeric sulfur.


name: CASL_HUMAN Enhancer of filamentation 1 (sprot)

description: An enhancer of filamentation 1 that is encoded in the genome of human.


meropenem

A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively.


name: OXSM_HUMAN 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (sprot)

description: A 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial that is encoded in the genome of human.


cadmium atom

An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.


name: EFS_HUMAN Embryonal Fyn-associated substrate (sprot)

description: An embryonal Fyn-associated substrate that is encoded in the genome of human.


name: GTR1_HUMAN Solute carrier family 2, facilitated glucose transporter member 1 (sprot)

description: A solute carrier family 2, facilitated glucose transporter member 1 that is encoded in the genome of human.


NFS1_HUMAN Cysteine desulfurase (sprot)

A cysteine desulfurase NFS1 that is encoded in the genome of human.


TRANSCROCETIN

A 20-carbon dicarboxylic acid which is a diterpenoid and natural carotenoid. Found in the crocus flower, it has been administered as an anti-fatigue dietary supplement.


pancreatic neuroendocrine tumor

description: Pancreatic endocrine tumor, also known as pancreatic neuroendocrine tumor (PNET), describes a group of endocrine tumors originating in the pancreas that are usually indolent and benign, but may have the potential to be malignant. They can be functional, exhibiting a hormonal hypersecretion syndrome, but can be non-functional presenting with non-specific symptoms and include insulinoma, glucagonoma, VIPoma, somatostatinoma (SSoma), PPoma and Zollinger-Ellison syndrome (ZES, or gastrinoma) and other ectopic hormone producing tumors (such as GRFoma).


piroxicam

A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.


Stevens-Johnson syndrome

description: Stevens-Johnson syndrome is a limited form of toxic epidermal necrolysis characterized by destruction and detachment of the skin epithelium and mucous membranes involving less than 10% of the body surface area.


Fanconi anemia complementation group C

description: Fanconi anemia caused by mutations of the FANCC gene. This gene provides instructions for making a protein that delays the onset of apoptosis and promotes homologous recombination repair of damaged DNA.


name: SEM1_HUMAN 26S proteasome complex subunit SEM1 (sprot)

description: A 26S proteasome complex subunit DSS1 that is encoded in the genome of human.


tauroursodeoxycholic acid

A bile acid taurine conjugate derived from ursoodeoxycholic acid.


name: PDCD4_HUMAN Programmed cell death protein 4 (sprot)

description: A programmed cell death protein 4 that is encoded in the genome of human.


heart disorder

description: A disease involving the heart and/or pericardium.


ROLIPRAM

A member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position.  It is a type IV-specific phosphodiesterase (PDE4) inhibitor.


MUSCIMOL

A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.


linoleic acid

An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.


skin carcinoma

description: A carcinoma that arises from epithelial cells of the zone of skin


name: PTGDS_HUMAN Prostaglandin-H2 D-isomerase (sprot)

description: A prostaglandin-H2 D-isomerase that is encoded in the genome of human.


cutaneous leishmaniasis

description: Leishmaniasis affecting the skin. It is the most common form of leishmaniasis. It presents with erythematous macules and papules, and nodules which may eventually ulcerate. The lesions appear in the bite site in the exposed skin areas.


L-methionine

The L-enantiomer of methionine.


ELN_HUMAN Elastin (sprot)

An elastin that is encoded in the genome of human.


name: M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (sprot)

description: A mitogen-activated protein kinase kinase kinase 5 that is encoded in the genome of human.


name: CARD6_HUMAN Caspase recruitment domain-containing protein 6 (sprot)

description: A caspase recruitment domain-containing protein 6 that is encoded in the genome of human.


CD81_HUMAN CD81 antigen (sprot)

A CD81 molecule that is encoded in the genome of human.


name: DDR2_HUMAN Discoidin domain-containing receptor 2 (sprot)

description: A discoidin domain-containing receptor 2 that is encoded in the genome of human.


pulmonary hypoplasia

description: A respiratory malformation characterized by the presence of both bronchi (albeit rudimentary) and alveoli in an under-developed lobe. Both the size and the weight of the lung are reduced. The true prevalence is not well known (1.4% of all births according to Knox et al. 13), but in cases of premature rupture of membranes at 15-28 weeks gestation, the reported prevalence of pulmonary hypoplasia ranges from 9 to 28%. Factors that contribute to pulmonary hypoplasia include adequate volume of the thoracic cavity, pulmonary fluid dynamics, and abnormal fetal breathing movements.


name: PDE4A_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4A (sprot)

description: A 3',5'-cyclic-AMP phosphodiesterase 4A that is encoded in the genome of human.


name: ST38L_HUMAN Serine/threonine-protein kinase 38-like (sprot)

description: A serine/threonine-protein kinase 38-like that is encoded in the genome of human.


name: NTRK2_HUMAN BDNF/NT-3 growth factors receptor (sprot)

description: A BDNF/NT-3 growth factors receptor that is encoded in the genome of human.


name: SO5A1_HUMAN Solute carrier organic anion transporter family member 5A1 (sprot)

description: A solute carrier organic anion transporter family member 5A1 that is encoded in the genome of human.


PRL_HUMAN Prolactin (sprot)

A prolactin that is encoded in the genome of human.


name: CPSF5_HUMAN Cleavage and polyadenylation specificity factor subunit 5 (sprot)

description: A cleavage and polyadenylation specificity factor subunit 5 that is encoded in the genome of human.


PYRROLOQUINOLINE QUINONE

A pyrroloquinoline having oxo groups at the 4- and 5-positions and carboxy groups at the 2-, 7- and 9-positions.


name: NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1 (sprot)

description: An NAD(P)H dehydrogenase [quinone] 1 that is encoded in the genome of human.


factor X deficiency

description: A coagulation disorder characterized by the partial or complete absence of factor X activity in the blood.


name: RASD1_HUMAN Dexamethasone-induced Ras-related protein 1 (sprot)

description: A dexamethasone-induced Ras-related protein 1 that is encoded in the genome of human.


gadoteric acid

A gadolinium coordination entity consisting of DOTA in which the four amino groups are bound to a central gadolinium atom. It is used (as its meglumine salt) in magnetic resonance imaging (MRI) in brain (intracranial), spine and associated tissues of patients ages 2 years and older, to detect and visualise areas with disruption of the blood brain barrier and/or abnormal vascularity of the central nervous system.


name: PCM1_HUMAN Pericentriolar material 1 protein (sprot)

description: A pericentriolar material 1 protein that is encoded in the genome of human.


Bone marrow hypocellularity

description: A reduced number of hematopoietic cells present in the bone marrow relative to marrow fat.


name: GPX4_HUMAN Phospholipid hydroperoxide glutathione peroxidase GPX4 (sprot)

description: A phospholipid hydroperoxide glutathione peroxidase GPX4 that is encoded in the genome of human.


naproxen

A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation  and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.


hantavirus infectious disease

description: Any infection caused by a virus of the genus Hantavirus, which is transmitted by aerosolized rodent excreta or rodent bites, that can result in a variety of clinical manifestations from hemorrhagic fever with renal syndrome to a pulmonary syndrome.


NEBULARINE

A purine ribonucleoside that is 9H-purine attached to a beta-D-ribofuranosyl residue at position 9 via a glycosidic (N-glycosyl) linkage.


name: MBL2_HUMAN Mannose-binding protein C (sprot)

description: A mannose-binding protein C that is encoded in the genome of human.


sodium fluoride

A metal fluoride salt with a Na(+) counterion.


name: ENTP1_HUMAN Ectonucleoside triphosphate diphosphohydrolase 1 (sprot)

description: An ectonucleoside triphosphate diphosphohydrolase 1 that is encoded in the genome of human.


name: NOS3_HUMAN Nitric oxide synthase 3 (sprot)

description: A nitric oxide synthase 3 that is encoded in the genome of human.


name: HBG1_HUMAN Hemoglobin subunit gamma-1 (sprot)

description: A hemoglobin subunit gamma-1 that is encoded in the genome of human.


docetaxel

A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.


name: GRK5_HUMAN G protein-coupled receptor kinase 5 (sprot)

description: A G protein-coupled receptor kinase 5 that is encoded in the genome of human.


name: PHLP2_HUMAN PH domain leucine-rich repeat-containing protein phosphatase 2 (sprot)

description: A PH domain leucine-rich repeat-containing protein phosphatase 2 that is encoded in the genome of human.


name: UROK_HUMAN Urokinase-type plasminogen activator (sprot)

description: A urokinase-type plasminogen activator that is encoded in the genome of human.


lovastatin

A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).


alternative prion protein (human)

A PRNP gene translation product (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:F7VJQ1-1.


name: CHPT1_HUMAN Cholinephosphotransferase 1 (sprot)

description: A cholinephosphotransferase 1 that is encoded in the genome of human.


name: LONP2_HUMAN Lon protease homolog 2, peroxisomal (sprot)

description: A peroxisomal Lon protease 2 that is encoded in the genome of human.


name: MRP5_HUMAN ATP-binding cassette sub-family C member 5 (sprot)

description: An ATP-binding cassette sub-family C member 5 that is encoded in the genome of human.


VALINOMYCIN

A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains.


Dysphagia

description: Difficulty in swallowing.


name: SOX10_HUMAN Transcription factor SOX-10 (sprot)

description: A transcription factor SOX-10 that is encoded in the genome of human.


GLYCYROL

A member of the class of  coumestans that is coumestan substituted by hydroxy groups at positions  1 and 9,  a methoxy group at position 3 and a prenyl group at position 2 respectively.


name: MYLK_HUMAN Myosin light chain kinase, smooth muscle (sprot)

description: A myosin light chain kinase, smooth muscle that is encoded in the genome of human.


name: GBP2_HUMAN Guanylate-binding protein 2 (sprot)

description: A guanylate-binding protein 2 that is encoded in the genome of human.


inflammatory breast carcinoma

description: An advanced, invasive breast adenocarcinoma characterized by the presence of distinct changes in the overlying skin. These changes include diffuse erythema, edema, peau d'orange (skin of an orange) appearance, tenderness, induration, warmth, enlargement, and in some cases a palpable mass. The skin changes are the consequence of lymphatic obstruction from the underlying invasive breast adenocarcinoma. Microscopically, the dermal lymphatics show prominent infiltration by malignant cells. The invasive breast adenocarcinoma is usually of ductal, NOS type. There is not significant inflammatory cell infiltrate present, despite the name of this carcinoma.


name: KPCG_HUMAN Protein kinase C gamma type (sprot)

description: A protein kinase C gamma type that is encoded in the genome of human.


aminooxyacetic acid

A member of the class of hydroxylamines that is acetic acid substituted at postion 2 by an aminooxy group. It is a compound which inhibits aminobutyrate aminotransferase activity in vivo, resulting in increased levels of gamma-aminobutyric acid in tissues.


hydrochlorothiazide

A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.


name: THY1_HUMAN Thy-1 membrane glycoprotein (sprot)

description: A Thy-1 membrane glycoprotein that is encoded in the genome of human.


2,4,6-trinitrobenzenesulfonic acid

The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.


colitis

description: Inflammation of the colon.


primary progressive multiple sclerosis

description: A multiple sclerosis that is characterized by steady worsening of neurologic functioning, without any distinct relapses or periods of remission. The rate of progression may vary over time, with occasional plateaus or temporary improvements, but the progression is continuous.


sucrose

A glycosyl glycoside formed by glucose and fructose units joined by an acetal oxygen bridge from hemiacetal of glucose to the hemiketal of the fructose.


NPS_HUMAN Neuropeptide S (sprot)

A neuropeptide S that is encoded in the genome of human.


name: carbamoyl phosphate synthetase I deficiency disease

description: Carbamoyl-phosphate synthetase 1 deficiency (CPS1D) is a rare and severe disorder of urea cycle metabolism most commonly characterized by either a neonatal-onset of severe hyperammonemia that occurs few days after birth and manifests with lethargy, vomiting, hypothermia, seizures, coma and death or a presentation outside the newborn period at any age with (sometimes) milder symptoms of hyperammonemia.


name: DMC1_HUMAN Meiotic recombination protein DMC1/LIM15 homolog (sprot)

description: A meiotic recombination protein DMC1/LIM15 that is encoded in the genome of human.


name: SWI5_HUMAN DNA repair protein SWI5 homolog (sprot)

description: A DNA repair protein SWI5 homolog that is encoded in the genome of human.


name: TIAM1_HUMAN Rho guanine nucleotide exchange factor TIAM1 (sprot)

description: A Rho guanine nucleotide exchange factor TIAM1 that is encoded in the genome of human.


breast adenocarcinoma

description: A carcinoma that arises from glandular epithelial cells of the breast


sonidegib

A member of the classo of biphenyls that is the amide obtained by formal condensation of the carboxy group of 2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid with the amino group of 6-(2,6-dimethylmorpholin-4-yl)pyridin-3-amine. Used (as its phosphate salt) for treatment of locally advanced basal cell carcinoma.


name: LRP2_HUMAN Low-density lipoprotein receptor-related protein 2 (sprot)

description: A low-density lipoprotein receptor-related protein 2 that is encoded in the genome of human.


name: ACSL3_HUMAN Fatty acid CoA ligase Acsl3 (sprot)

description: A fatty acid CoA ligase Acsl3 that is encoded in the genome of human.


name: NPAS4_HUMAN Neuronal PAS domain-containing protein 4 (sprot)

description: A neuronal PAS domain-containing protein 4 that is encoded in the genome of human.


magnesium sulfate

A magnesium salt having sulfate as the counterion.


GALP_HUMAN Galanin-like peptide (sprot)

A galanin-like peptide that is encoded in the genome of human.


perifosine

A phospholipid consisting of 1,1-dimethylpiperidinium-4-yl hydrogen phosphate in which the hydrogen is replaced by a stearyl (octadecyl) group.


metyrapone

An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.


name: AL1B1_HUMAN Aldehyde dehydrogenase X, mitochondrial (sprot)

description: An aldehyde dehydrogenase X, mitochondrial that is encoded in the genome of human.


5NTD_HUMAN 5'-nucleotidase (sprot)

A 5'-nucleotidase that is encoded in the genome of human.


name: CTLA4_HUMAN Cytotoxic T-lymphocyte protein 4 (sprot)

description: A cytotoxic T-lymphocyte protein 4 that is encoded in the genome of human.


name: RFC1_HUMAN Replication factor C subunit 1 (sprot)

description: A replication factor C subunit 1 that is encoded in the genome of human.


name: OREX_HUMAN Hypocretin neuropeptide precursor (sprot)

description: A hypocretin neuropeptide precursor that is encoded in the genome of human.


invasive ductal breast carcinoma

description: The most common type of invasive breast carcinoma, accounting for approximately 70% of breast carcinomas. The gross appearance is usually typical with an irregular stellate outline. Microscopically, randomly arranged epithelial elements are seen. When large sheets of malignant cells are present, necrosis may be seen. With adequate tissue sampling, in situ carcinoma can be demonstrated in association with the infiltrating carcinoma. The in situ component is nearly always ductal but occasionally may be lobular or both.


oxybutynin

A carboxylic ester resulting from the formal condensation of the carboxy group of cyclohexyl(hydroxy)phenylacetic acid with the hydroxy group of 4-(diethylamino)but-2-yn-1-ol.


primary angle-closure glaucoma

description: An angle-closure glaucoma characterized by closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Primary angle-closure glaucoma has symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Primary angle closure glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component.


name: autosomal dominant polycystic liver disease

description: An autosomal dominant inherited condition characterized by many cysts of various sizes scattered throughout the liver.


dipyridamole

A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.


name: S52A2_HUMAN Solute carrier family 52, riboflavin transporter, member 2 (sprot)

description: A solute carrier family 52, riboflavin transporter, member 2 that is encoded in the genome of human.


distal colitis

description: Particular variety of ulcerative colitis where only the left half of the colon is inflamed.


heparin

A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1->4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.


pituitary gland adenoma

description: A non-metastasizing tumor that arises from the adenohypophysial cells of the anterior lobe of the pituitary gland. The tumor can be hormonally functioning or not. The diagnosis can be based on imaging studies and/or radioimmunoassays. Due to its location in the sella turcica, expansion of the tumor mass can impinge on the optic chiasm or involve the temporal lobe, third ventricle and posterior fossa A frequently associated physical finding is bitemporal hemianopsia which may progress to further visual loss.


name: SYC1L_HUMAN Synaptonemal complex central element protein 1-like (sprot)

description: A synaptonemal complex central element protein 1-like that is encoded in the genome of human.


name: AR6P1_HUMAN ADP-ribosylation factor-like protein 6-interacting protein 1 (sprot)

description: An ADP-ribosylation factor-like protein 6-interacting protein 1 that is encoded in the genome of human.


BRYOSTATIN 1

A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoethylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of bryostatins.


name: MK15_HUMAN Mitogen-activated protein kinase 15 (sprot)

description: A mitogen-activated protein kinase 15 that is encoded in the genome of human.


alcaftadine

An imidazobenzazepine that is 6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine substituted at position 3 by a formyl group and at position 11 by a 1-methylpiperidin-4-ylidene group. An antihistamine used for treatment of allergic conjunctivitis.


α-linolenic acid

A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect.


name: ELOV6_HUMAN Very long chain fatty acid elongase 6 (sprot)

description: A very long chain fatty acid elongase 6 that is encoded in the genome of human.


name: NAA10_HUMAN N-alpha-acetyltransferase 10 (sprot)

description: An N-alpha-acetyltransferase 10 that is encoded in the genome of human.


name: ZN363_HUMAN RING finger and CHY zinc finger domain-containing protein 1 (sprot)

description: A RING finger and CHY zinc finger domain-containing protein 1 that is encoded in the genome of human.


CNTN2_HUMAN Contactin-2 (sprot)

A contactin-2 that is encoded in the genome of human.


name: APBB1_HUMAN Amyloid beta precursor protein binding family B member 1 (sprot)

description: An amyloid beta precursor protein binding family B member 1 that is encoded in the genome of human.


chlorhexidine

A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.


CATB_HUMAN Cathepsin B (sprot)

A cathepsin B that is encoded in the genome of human.


name: MEF2C_HUMAN Myocyte-specific enhancer factor 2C (sprot)

description: A myocyte-specific enhancer factor 2C that is encoded in the genome of human.


name: LRSM1_HUMAN E3 ubiquitin-protein ligase LRSAM1 (sprot)

description: An E3 ubiquitin-protein ligase LRSAM1 that is encoded in the genome of human.


name: RL40_HUMAN Ubiquitin-ribosomal protein eL40 fusion protein (sprot)

description: A ubiquitin-ribosomal protein eL40 fusion protein that is encoded in the genome of human.


branched-chain amino acid

Any  amino acid  in which the parent hydrocarbon chain has one or more alkyl substituents


diacylglycerol (18:0/20:4/0:0)

A 1,2-diglyceride in which the fatty acyl groups at positions 1 and 2 are specified as C18:0 and C20:4 respectively.


CYH3_HUMAN Cytohesin-3 (sprot)

A cytohesin-3 that is encoded in the genome of human.


name: AOFA_HUMAN Amine oxidase [flavin-containing] A (sprot)

description: An amine oxidase [flavin-containing] A that is encoded in the genome of human.


prostate adenocarcinoma

description: A carcinoma that arises from glandular epithelial cells of the prostate gland


name: PTPRU_HUMAN Receptor-type tyrosine-protein phosphatase U (sprot)

description: A receptor-type tyrosine-protein phosphatase U that is encoded in the genome of human.


name: PCP2_HUMAN Purkinje cell protein 2 homolog (sprot)

description: A Purkinje cell protein 2 that is encoded in the genome of human.


phosphatidylethanolamine (16:0/22:5)

A 1,2-diacyl-sn-glycero-3-phosphoethanolamine in which the acyl group at C-1 contains 16 carbons and no double bonds while that at C-2 contains 22 carbons and 5 double bonds.


name: SRC8_HUMAN Src substrate cortactin (sprot)

description: A Src substrate cortactin that is encoded in the genome of human.


chrysin

A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.


name: SC23A_HUMAN Protein transport protein Sec23A (sprot)

description: A protein transport protein Sec23A that is encoded in the genome of human.


clofarabine

A purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia.


name: TNR6_HUMAN Tumor necrosis factor receptor superfamily member 6 (sprot)

description: A tumor necrosis factor receptor superfamily member 6 that is encoded in the genome of human.


name: FCGRB_HUMAN Putative high affinity immunoglobulin gamma Fc receptor IB (sprot)

description: A putative high affinity immunoglobulin gamma Fc receptor IB that is encoded in the genome of human.


CASP6_HUMAN Caspase-6 (sprot)

A caspase-6 that is encoded in the genome of human.


OPRX_HUMAN Nociceptin receptor (sprot)

A nociceptin receptor that is encoded in the genome of human.


osteomyelitis

description: An acute or chronic inflammation of the bone and its structures due to infection with pyogenic bacteria.


basal cell carcinoma

description: A carcinoma involving the basal cells.


name: PRDX3_HUMAN Thioredoxin-dependent peroxide reductase, mitochondrial (sprot)

description: A thioredoxin-dependent peroxide reductase, mitochondrial that is encoded in the genome of human.


name: RAB13_HUMAN Ras-related protein Rab-13 (sprot)

description: A Ras-related protein Rab-13 that is encoded in the genome of human.


name: SOX2_HUMAN Transcription factor SOX-2 (sprot)

description: A transcription factor SOX-2 that is encoded in the genome of human.


MGLL_HUMAN Monoglyceride lipase (sprot)

A monoglyceride lipase that is encoded in the genome of human.


name: ROR1_HUMAN Inactive tyrosine-protein kinase transmembrane receptor ROR1 (sprot)

description: A tyrosine-protein kinase transmembrane receptor ROR1 that is encoded in the genome of human.


CD70_HUMAN CD70 antigen (sprot)

A CD70 molecule that is encoded in the genome of human.


CD27_HUMAN CD27 antigen (sprot)

A CD27 molecule that is encoded in the genome of human.


name: AP2A_HUMAN Transcription factor AP-2-alpha (sprot)

description: A transcription factor AP-2-alpha that is encoded in the genome of human.


(-)-adrenaline

The R-enantiomer of adrenaline. It is a hormone secreted by the adrenal glands resulting in the 'fight-or-flight' response.


infective vaginitis

description: An infectious process affecting the vagina. Symptoms include pain and purulent discharge.


name: FBW1A_HUMAN F-box/WD repeat-containing protein 1A (sprot)

description: An F-box/WD repeat-containing protein 1A that is encoded in the genome of human.


name: MARK2_HUMAN Serine/threonine-protein kinase MARK2 (sprot)

description: A serine/threonine-protein kinase MARK2 that is encoded in the genome of human.


leuprolide

An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.


name: GNRHR_HUMAN Gonadotropin-releasing hormone receptor (sprot)

description: A gonadotropin-releasing hormone I receptor that is encoded in the genome of human.


biotin

An organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins.


sensorineural hearing loss disorder

description: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).


name: NGAL_HUMAN Neutrophil gelatinase-associated lipocalin (sprot)

description: A neutrophil gelatinase-associated lipocalin that is encoded in the genome of human.


name: CTR1_HUMAN High affinity cationic amino acid transporter 1 (sprot)

description: A high affinity cationic amino acid transporter 1 that is encoded in the genome of human.


name: CHD4_HUMAN Chromodomain-helicase-DNA-binding protein 4 (sprot)

description: A chromodomain-helicase-DNA-binding protein 4 that is encoded in the genome of human.


ITAX_HUMAN Integrin alpha-X (sprot)

An integrin alpha-X that is encoded in the genome of human.


CANDESARTAN

A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension.


pazopanib

A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.


name: GSTM1_HUMAN Glutathione S-transferase Mu 1 (sprot)

description: A glutathione S-transferase mu 1 that is encoded in the genome of human.


sudden cardiac arrest

description: The sudden loss of all heart activity due to an irregular heart rhythm.


name: S12A5_HUMAN Solute carrier family 12 member 5 (sprot)

description: A solute carrier family 12 member 5 that is encoded in the genome of human.


TBB3_HUMAN Tubulin beta-3 chain (sprot)

A tubulin beta-3 chain that is encoded in the genome of human.


name: KRIT1_HUMAN Krev interaction trapped protein 1 (sprot)

description: A Krev interaction trapped protein 1 that is encoded in the genome of human.


name: DDX5_HUMAN Probable ATP-dependent RNA helicase DDX5 (sprot)

description: A probable ATP-dependent RNA helicase DDX5 that is encoded in the genome of human.


FORMONONETIN

A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'.


name: ELOV3_HUMAN Very long chain fatty acid elongase 3 (sprot)

description: A very long chain fatty acid elongase 3 that is encoded in the genome of human.


name: CR2_HUMAN Complement receptor type 2 (sprot)

description: A complement receptor type 2 that is encoded in the genome of human.


cytisine

An organic heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. An acetylcholine agonist, it is widely used throughout Eastern Europe as an aid to giving up smoking.


S-MENASTROL

An ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate that has S configuration.


name: GATA6_HUMAN Transcription factor GATA-6 (sprot)

description: A transcription factor GATA-6 that is encoded in the genome of human.


name: SUMO1_HUMAN Small ubiquitin-related modifier 1 (sprot)

description: A small ubiquitin-related modifier 1 that is encoded in the genome of human.


name: EF1A1_HUMAN Elongation factor 1-alpha 1 (sprot)

description: An elongation factor 1-alpha 1 that is encoded in the genome of human.


name: PADI2_HUMAN Protein-arginine deiminase type-2 (sprot)

description: A protein-arginine deiminase type-2 that is encoded in the genome of human.


name: NFKB2_HUMAN Nuclear factor NF-kappa-B p100 subunit (sprot)

description: A nuclear factor NF-kappa-B p100 subunit that is encoded in the genome of human.


chloroform

A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.


sterol

Any 3-hydroxy steroid whose skeleton is closely related to cholestan-3-ol (additional carbon atoms may be present in the side chain).


colon adenocarcinoma

description: A carcinoma that arises from glandular epithelial cells of the colon


lidocaine

The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.


cataract

description: Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.)


name: RBP1_HUMAN RalA-binding protein 1 (sprot)

description: A RalA-binding protein 1 that is encoded in the genome of human.


OPTN_HUMAN Optineurin (sprot)

An optineurin that is encoded in the genome of human.


ergotamine

A peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10.


MYCL_HUMAN Protein L-Myc (sprot)

A protein L-Myc that is encoded in the genome of human.


Lysergide

An ergoline alkaloid arising from formal condensation of lysergic acid with diethylamine.


phytanic acid

A branched-chain saturated fatty acid consisting of hexadecanoic acid carrying methyl substituents at positions 3, 7, 11 and 15.


name: CO4A1_HUMAN Collagen alpha-1(IV) chain (sprot)

description: A collagen alpha-1(IV) chain that is encoded in the genome of human.


name: KLHL1_HUMAN Kelch-like protein 1 (sprot)

description: A kelch-like protein 1 that is encoded in the genome of human.


CD63_HUMAN CD63 antigen (sprot)

A CD63 molecule that is encoded in the genome of human.


name: PER2_HUMAN Period circadian protein homolog 2 (sprot)

description: A period circadian protein homolog 2 that is encoded in the genome of human.


name: GRB2_HUMAN Growth factor receptor-bound protein 2 (sprot)

description: A growth factor receptor-bound protein 2 that is encoded in the genome of human.


myristic acid

A straight-chain, fourteen-carbon, long-chain saturated fatty acid mostly found in milk fat.


Legg-Calve-Perthes disease

description: A hip region disease that is characterized by uni- or bilateral avascular necrosis (AVN) of the femoral head in children. In a small percentage of cases, mutations in the COL2A1 gene were found to be responsible.


name: FCG3A_HUMAN Low affinity immunoglobulin gamma Fc region receptor III-A (sprot)

description: A low affinity immunoglobulin gamma Fc region receptor III-A that is encoded in the genome of human.


name: DAF_HUMAN Complement decay-accelerating factor (sprot)

description: A complement decay-accelerating factor that is encoded in the genome of human.


Periorbital edema

description: Edema affecting the region situated around the orbit of the eye.


name: KCNK3_HUMAN Potassium channel subfamily K member 3 (sprot)

description: A potassium channel subfamily K member 3 that is encoded in the genome of human.


name: SMUF2_HUMAN E3 ubiquitin-protein ligase SMURF2 (sprot)

description: An E3 ubiquitin-protein ligase SMURF2 that is encoded in the genome of human.


EZRI_HUMAN Ezrin (sprot)

An ezrin that is encoded in the genome of human.


name: ACTS_HUMAN Actin, alpha skeletal muscle (sprot)

description: An actin, alpha skeletal muscle that is encoded in the genome of human.


A pyrrolopyridine that is vemurafenib in which the p-chlorophenyl group has been replaced by chlorine. It is a potent and selective inhibitor of the Raf kinase B-Raf(V600E).


ESR1_HUMAN Estrogen receptor (sprot)

An estrogen receptor that is encoded in the genome of human.


name: HOP2_HUMAN Homologous-pairing protein 2 homolog (sprot)

description: A homologous-pairing protein 2 that is encoded in the genome of human.


name: CDT1_HUMAN DNA replication factor Cdt1 (sprot)

description: A DNA replication factor Cdt1 that is encoded in the genome of human.


name: FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP5 that is encoded in the genome of human.


granulosa cell tumor

description: A slow-growing, malignant tumor, characterize by the presence of granulosa-like cells and Call-Exner bodies, that is almost always found in the ovary. In rare cases, it has also been found in the testicle. There are two types of granulosa cell tumor that can be distinguished under the microscope: the adult and the juvenile. The testicular juvenile granulosa cell tumors are perhaps the most common congenital testicular neoplasms.


name: DEGS2_HUMAN Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 (sprot)

description: A sphingolipid Delta(4)-desaturase/C4-monooxygenase DES2 that is encoded in the genome of human.


diacylglycerol (18:0/22:6/0:0)

A 1,2-diglyceride in which the fatty acyl groups at positions 1 and 2 are specified as C18:0 and C22:6 respectively.


thioridazine

A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.


name: RO52_HUMAN E3 ubiquitin-protein ligase TRIM21 (sprot)

description: An E3 ubiquitin-protein ligase TRIM21 that is encoded in the genome of human.


name: BST2_HUMAN Bone marrow stromal antigen 2 (sprot)

description: A bone marrow stromal antigen 2 that is encoded in the genome of human.


Hyperuricemia

description: An abnormally high level of uric acid in the blood.


anosmia

description: Loss of or impaired ability to smell. This may be caused by olfactory nerve diseases; paranasal sinus diseases; viral respiratory tract infections; craniocerebral trauma; smoking; and other conditions.


name: FOXO1_HUMAN Forkhead box protein O1 (sprot)

description: A forkhead box protein O1 that is encoded in the genome of human.


misoprostol (methyl ester)

A diastereoisomeric mixture composed of approximately equal amounts of a double racemate of four of the sixteen possible diastereoisomers of methyl (13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate that is racemic prostaglandin E1 which is lacking the hydroxy group at position 15, but which has an additional hydroxy group at position 16. It is a synthetic prostaglandin E1 analogue, used in the treatment of gastric and duodenal ulcers. A weak abortifacient, it is also used for cervical ripening prior to surgical termination of pregnancy. The (11R,16S)-diastereoisomer is the pharmacologically active form.


gastrointestinal stromal tumor

description: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal (GI) tract, typically presenting in adults over the age of 40 (mean age 63), and only rarely in children, in various regions of the GI tract, most commonly the stomach or small intestine but also less commonly in the esophagus, appendix, rectum and colon. GISTs can be asymptomatic or present with various non-specific signs, depending on the location and size of tumor, such as loss of appetite, anemia, weight loss, fatigue, abdominal discomfort or fullness, nausea, vomiting, as well as an abdominal mass, blood in stool, and intestinal obstruction. GISTs can also be seen in familial syndromes such as Carney triad and neurofibromatosis type 1.


name: HCN1_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (sprot)

description: A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is encoded in the genome of human.


name: KCNA2_HUMAN Potassium voltage-gated channel subfamily A member 2 (sprot)

description: A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of human.


GAST_HUMAN Gastrin (sprot)

A gastrin that is encoded in the genome of human.


name: PTK7_HUMAN Inactive tyrosine-protein kinase 7 (sprot)

description: An inactive tyrosine-protein kinase 7 that is encoded in the genome of human.


name: TPM3_HUMAN Tropomyosin alpha-3 chain (sprot)

description: A tropomyosin alpha-3 chain that is encoded in the genome of human.


cetirizine

A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.


adenosine 5'-monophosphate

A purine ribonucleoside 5'-monophosphate having adenine as the nucleobase.


taraxasterol

A pentacyclic triterpenoid that is taraxastane with a beta-hydroxy group at position 3.


name: PAR6A_HUMAN Partitioning defective 6 homolog alpha (sprot)

description: A partitioning defective 6 homolog alpha that is encoded in the genome of human.


name: MTAP2_HUMAN Microtubule-associated protein 2 (sprot)

description: A microtubule-associated protein 2 that is encoded in the genome of human.


hearing loss disorder

description: A partial or complete loss of hearing in one or both ears. It is classified as conductive, sensory, or central.


name: MP2K4_HUMAN Dual specificity mitogen-activated protein kinase kinase 4 (sprot)

description: A dual specificity mitogen-activated protein kinase kinase 4 that is encoded in the genome of human.


name: CXB1_HUMAN Gap junction beta-1 protein (sprot)

description: A gap junction beta-1 protein that is encoded in the genome of human.


chondroitin sulfate

A chondroitin sulfate in which the site of sulfation is carbon 4 of the N-acetylgalactosamine (GalNAc) sugar.


empagliflozin

A C-glycosyl compound consisting of a beta-glucosyl residue having a (4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl group at the anomeric centre. A sodium-glucose co-transporter 2 inhibitor used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.


colorectal adenocarcinoma

description: The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.


malignant peritoneal mesothelioma

description: An aggressive malignant mesothelioma that arises from the peritoneum. Patients usually present with abdominal pain and ascites.


name: ERG24_HUMAN Delta(14)-sterol reductase TM7SF2 (sprot)

description: A Delta(14)-sterol reductase TM7SF2 that is encoded in the genome of human.


CUCURBITACIN E

A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23.


name: IL23A_HUMAN Interleukin-23 subunit alpha (sprot)

description: An interleukin-23 subunit alpha that is encoded in the genome of human.


name: MTDC_HUMAN Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (sprot)

description: A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial that is encoded in the genome of human.


GUC2A_HUMAN Guanylin (sprot)

A guanylin that is encoded in the genome of human.


name: ELOF1_HUMAN Transcription elongation factor 1 homolog (sprot)

description: A transcription elongation factor 1 that is encoded in the genome of human.


name: FOXD3_HUMAN Forkhead box protein D3 (sprot)

description: A forkhead box protein D3 that is encoded in the genome of human.


saracatinib

A member of the class of quinazolines that is quinazoline substituted by (5-chloro-2H-1,3-benzodioxol-4-yl)amino, (oxan-4-yl)oxy and 2-(4-methylpiperazin-1-yl)ethoxy groups at positions 4, 5 and 7, respectively. It is a dual inhibitor of the tyrosine kinases c-Src and Abl (IC50 = 2.7 and 30 nM, respectively). Saracatinib was originally developed by AstraZeneca for the treatment of cancer but in 2019 it was granted orphan drug designation by the US Food and Drug Administration for the treatment of idiopathic pulmonary fibrosis (IPF), a type of lung disease that results in scarring (fibrosis) of the lungs.


ovarian adenocarcinoma

description: An adenocarcinoma that arises from the ovary. It is the most common type of ovarian carcinoma. It includes the serous adenocarcinoma, mucinous adenocarcinoma, clear cell adenocarcinoma, and endometrioid adenocarcinoma.


calcium-alkali syndrome

description: The ingestion of excessive calcium supplementation or calcium containing antacids, and alkali resulting in a triad of hypercalcemia, metabolic alkalosis, and renal insufficiency.


TRICETIN

Flavone hydroxylated at positions 3', 4', 5, 5' and 7.


insomnia

description: A sleep disorder characterized by difficulty in falling asleep and/or remaining asleep.


hypertrophy of breast

description: Excessive enlargement of one or both breasts. Causes include pregnancy, obesity, and penicillamine therapy. It may result in neck, back, and shoulder pain.


chronic myelomonocytic leukemia

description: A myelodysplastic/myeloproliferative neoplasm which is characterized by persistent monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer than 20 percent blasts in the bone marrow and blood, myelodysplasia, and absence of PDGFRA or PDGFRB rearrangement.


name: RGAP1_HUMAN Rac GTPase-activating protein 1 (sprot)

description: A Rac GTPase-activating protein 1 that is encoded in the genome of human.


name: LRIG3_HUMAN Leucine-rich repeats and immunoglobulin-like domains protein 3 (sprot)

description: A leucine-rich repeats and immunoglobulin-like domains protein 3 that is encoded in the genome of human.


vulvar carcinoma

description: A carcinoma that arises from epithelial cells of the mammalian vulva


HXK2_HUMAN Hexokinase-2 (sprot)

A hexokinase-2 that is encoded in the genome of human.


phenytoin

A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5.


complex partial epilepsy

description: A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and automatism may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)


name: CSN6_HUMAN COP9 signalosome complex subunit 6 (sprot)

description: A COP9 signalosome complex subunit 6 that is encoded in the genome of human.


name: UBR5_HUMAN E3 ubiquitin-protein ligase UBR5 (sprot)

description: An E3 ubiquitin-protein ligase UBR5 that is encoded in the genome of human.


spinal muscular atrophy, type II

description: Proximal spinal muscular atrophy type 2 (SMA2) is a chronic infantile form of proximal spinal muscular atrophy characterized by muscle weakness and hypotonia resulting from the degeneration and loss of the lower motor neurons in the spinal cord and the brain stem nuclei.


name: HSPB1_HUMAN Heat shock protein beta-1 (sprot)

description: A heat shock protein beta-1 that is encoded in the genome of human.


name: RS20_HUMAN Small ribosomal subunit protein uS10 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS10 that is encoded in the genome of human.


pentamidine

A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A  trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.


name: TBX15_HUMAN T-box transcription factor TBX15 (sprot)

description: A T-box transcription factor TBX15 that is encoded in the genome of human.


A member of the class of imidazopyridines that is 4-(1-ethylimidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol carrying additional 2-(4-amino-1,2,5-oxadiazol-3-yl and [(3S)-piperidin-3-yl]methoxy substituents at positions 4 and 7 respectively.


A tocol in which the hydrocarbon chain at position 2 contains three double bonds.


glycyrrhizin

A  triterpenoid saponin that is the  glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.


vaccinia

description: The cutaneous and occasional systemic reactions associated with vaccination using smallpox (variola) vaccine.


name: AL3A1_HUMAN Aldehyde dehydrogenase, dimeric NADP-preferring (sprot)

description: An aldehyde dehydrogenase, dimeric NADP-preferring that is encoded in the genome of human.


name: ODPA_HUMAN Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (sprot)

description: A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial that is encoded in the genome of human.


name: AP2C_HUMAN Transcription factor AP-2 gamma (sprot)

description: A transcription factor AP-2 gamma that is encoded in the genome of human.


TLR1_HUMAN Toll-like receptor 1 (sprot)

A Toll-like receptor 1 that is encoded in the genome of human.


idebenone

A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.


name: CO7A1_HUMAN Collagen alpha-1(VII) chain (sprot)

description: A collagen alpha-1(VII) chain that is encoded in the genome of human.


keto-D-fructose 1,6-bisphosphate

A ketohexose bisphosphate that is D-fructose substituted by phosphate groups at positions 1 and 6.


name: MPIP3_HUMAN M-phase inducer phosphatase 3 (sprot)

description: An M-phase inducer phosphatase 3 that is encoded in the genome of human.


TPO_HUMAN Thrombopoietin (sprot)

A thrombopoietin that is encoded in the genome of human.


name: ORNT1_HUMAN Mitochondrial ornithine transporter 1 (sprot)

description: A mitochondrial ornithine transporter 1 that is encoded in the genome of human.


brain ischemia

description: Diminished or absent blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurologic damage.


L-carnitine

The (R)-enantiomer of carnitine.


Peyronie disease

description: A condition characterized by hardening of the penis due to the formation of fibrous plaques on the dorsolateral aspect of the penis, usually involving the membrane (tunica albuginea) surrounding the erectile tissue (corpus cavernosum penis). This may eventually cause a painful deformity of the shaft or constriction of the urethra, or both.


alpha-terpineol

A terpineol that is propan-2-ol substituted by a 4-methylcyclohex-3-en-1-yl group at position 2.


name: TCAL1_HUMAN Transcription elongation factor A protein-like 1 (sprot)

description: A transcription elongation factor A protein-like 1 that is encoded in the genome of human.


VACCENIC ACID

The cis isomer of vaccenic acid.


name: IL1RA_HUMAN Interleukin-1 receptor antagonist protein (sprot)

description: An interleukin-1 receptor antagonist protein that is encoded in the genome of human.


CAV1_HUMAN Caveolin-1 (sprot)

A caveolin-1 that is encoded in the genome of human.


name: LRP1_HUMAN Prolow-density lipoprotein receptor-related protein 1 (sprot)

description: A low-density lipoprotein receptor-related protein 1 that is encoded in the genome of human.


name: BMP3_HUMAN Bone morphogenetic protein 3 (sprot)

description: A bone morphogenetic protein 3 that is encoded in the genome of human.


name: JAM1_HUMAN Junctional adhesion molecule A (sprot)

description: A junctional adhesion molecule A that is encoded in the genome of human.


lorcaserin

A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine substituted at position 1 by a methyl group and a t position 6 by a chloro group.


name: ERAP1_HUMAN Endoplasmic reticulum aminopeptidase 1 (sprot)

description: An endoplasmic reticulum aminopeptidase 1 that is encoded in the genome of human.


name: PLAP_HUMAN Phospholipase A-2-activating protein (sprot)

description: A phospholipase A-2-activating protein that is encoded in the genome of human.


acetyl-L-carnitine

An O-acyl-L-carnitine where the acyl group specified is acetyl. It facilitates movement of acetyl-CoA into the matrices of mammalian mitochondria during the oxidation of fatty acids.


diabetic neuropathy

description: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.


name: RD23B_HUMAN UV excision repair protein RAD23 homolog B (sprot)

description: A UV excision repair protein RAD23 homolog B that is encoded in the genome of human.


name: TOM20_HUMAN Mitochondrial import receptor subunit TOM20 homolog (sprot)

description: A mitochondrial import receptor subunit TOM20 that is encoded in the genome of human.


sucralose

A disaccharide derivative consisting of 4-chloro-4-deoxy-alpha-D-galactopyranose and 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose units linked by a glycosidic bond.


name: MLRA_HUMAN Myosin regulatory light chain 2, atrial isoform (sprot)

description: A myosin regulatory light chain 2, atrial isoform that is encoded in the genome of human.


resminostat

An enamide resulting from the formal condensation of the carboxy group of (2E)-3-[1-({4-[(dimethylamino)methyl]phenyl}sulfonyl)-1H-pyrrol-3-yl]prop-2-enoic acid with the amino group of hydroxylamine. It is an orally bioavailable inhibitor of histone deacetylases with potential antineoplastic activity.


name: ESS2_HUMAN Splicing factor ESS-2 homolog (sprot)

description: A splicing factor ESS-2 homolog that is encoded in the genome of human.


N-ethylmaleimide

A member of the class of  maleimides that is the N-ethyl derivative of maleimide.


pregnenolone

A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.


name: TRPM3_HUMAN Transient receptor potential cation channel subfamily M member 3 (sprot)

description: A transient receptor potential cation channel subfamily M member 3 that is encoded in the genome of human.


name: PNMA2_HUMAN Paraneoplastic antigen Ma2 (sprot)

description: A paraneoplastic antigen Ma2 that is encoded in the genome of human.


CHRD_HUMAN Chordin (sprot)

A chordin that is encoded in the genome of human.


name: IF5A2_HUMAN Eukaryotic translation initiation factor 5A-2 (sprot)

description: A eukaryotic translation initiation factor 5A-2 that is encoded in the genome of human.


name: DHI2_HUMAN 11-beta-hydroxysteroid dehydrogenase type 2 (sprot)

description: An 11-beta-hydroxysteroid dehydrogenase type 2 that is encoded in the genome of human.


azacitidine

An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.


name: HYES_HUMAN Bifunctional epoxide hydrolase 2 (sprot)

description: An epoxide hydrolase 2 that is encoded in the genome of human.


name: M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 (sprot)

description: A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of human.


name: LAT1_HUMAN Large neutral amino acids transporter small subunit 1 (sprot)

description: A large neutral amino acids transporter small subunit 1 that is encoded in the genome of human.


clopidogrel

A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a  methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks.


pyuria

description: The presence of excessive white blood cells in the urine as determined by urinalysis.


diethylstilbestrol

An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.


bipolar disorder

description: A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.


name: TIF1A_HUMAN Transcription intermediary factor 1-alpha (sprot)

description: A transcription intermediary factor 1-alpha that is encoded in the genome of human.


hydroxytyrosol

A member of the class of catechols that is benzene-1,2-diol substituted by a 2-hydroxyethyl group at position 4. Isolated from Olea europaea, it exhibits antioxidant and antineoplastic activities.


omeprazole

A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.


urinary bladder cancer

description: A primary or metastatic malignant neoplasm involving the bladder.


foscarnet

Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.


remifentanil

A piperidinecarboxylate ester that is methyl piperidine-4-carboxylate in which the hydrogen attached to the nitrogen is substituted by a 3-methoxy-3-oxopropyl group and the hydrogen at position 4 is substituted the nitrogen of N-propanoylaniline.


S26A4_HUMAN Pendrin (sprot)

A pendrin that is encoded in the genome of human.


SERPH_HUMAN Serpin H1 (sprot)

A serpin H1 that is encoded in the genome of human.


name: ANM1_HUMAN Protein arginine N-methyltransferase 1 (sprot)

description: A protein arginine N-methyltransferase 1 that is encoded in the genome of human.


PLIN3_HUMAN Perilipin-3 (sprot)

A perilipin-3 that is encoded in the genome of human.


lactic acid

A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.


hyperplasia

description: An abnormal increase in the number of cells in an organ or a tissue with consequent enlargement.


metastatic melanoma

description: A melanoma that has spread from its primary site to another anatomic site. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.


hypertriglyceridemia

description: A laboratory test result indicating elevated triglyceride concentration in the blood.


SODIUM BUTYRATE

An organic sodium salt resulting from the replacement of the proton from the carboxy group of butyric acid by a sodium ion.


name: MYT1_HUMAN Myelin transcription factor 1 (sprot)

description: A myelin transcription factor 1 that is encoded in the genome of human.


name: KCNKD_HUMAN Potassium channel subfamily K member 13 (sprot)

description: A potassium channel subfamily K member 13 that is encoded in the genome of human.


HMOX2_HUMAN Heme oxygenase 2 (sprot)

A heme oxygenase 2 that is encoded in the genome of human.


CP2D6_HUMAN Cytochrome P450 2D6 (sprot)

A cytochrome P450 2D6 that is encoded in the genome of human.


benazepril

A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.


flurbiprofen

A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.


name: KCNA7_HUMAN Potassium voltage-gated channel subfamily A member 7 (sprot)

description: A voltage-gated potassium channel subunit KCNA7 that is encoded in the genome of human.


Leukocytosis

description: An abnormal increase in the number of leukocytes in the blood.


avanafil

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-[(3-chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid with the amino group of pyrimidin-2-ylmethylamine. Used for treatment of erectile dysfunction.


name: CD34_HUMAN Hematopoietic progenitor cell antigen CD34 (sprot)

description: A CD34 molecule that is encoded in the genome of human.


A primary amino compound that is the 5-hydroxy derivative of tryptamine.


name: MAP4_HUMAN Microtubule-associated protein 4 (sprot)

description: A microtubule-associated protein 4 that is encoded in the genome of human.


name: HNF1B_HUMAN Hepatocyte nuclear factor 1-beta (sprot)

description: A hepatocyte nuclear factor 1-beta that is encoded in the genome of human.


name: TPP1_HUMAN Tripeptidyl-peptidase 1 (sprot)

description: A tripeptidyl-peptidase 1 that is encoded in the genome of human.


name: IRF5_HUMAN Interferon regulatory factor 5 (sprot)

description: An interferon regulatory factor 5 that is encoded in the genome of human.


uridine

A ribonucleoside composed of a molecule of uracil attached to a ribofuranose moiety via a beta-N(1)-glycosidic bond.


probenecid

A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.


osteogenesis imperfecta

description: Osteogenesis imperfecta (OI) comprises a heterogeneous group of genetic disorders characterized by increased bone fragility, low bone mass, and susceptibility to bone fractures with variable severity.


name: PLCG1_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (sprot)

description: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 that is encoded in the genome of human.


CD82_HUMAN CD82 antigen (sprot)

A CD82 molecule that is encoded in the genome of human.


name: VA0D2_HUMAN V-type proton ATPase subunit d 2 (sprot)

description: A V-type proton ATPase subunit d 2 that is encoded in the genome of human.


Hypoalbuminemia

description: Reduction in the concentration of albumin in the blood.


name: ATS13_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 13 (sprot)

description: An a disintegrin and metalloproteinase with thrombospondin motifs 13 that is encoded in the genome of human.


FBX4_HUMAN F-box only protein 4 (sprot)

An F-box only protein 4 that is encoded in the genome of human.


name: FXR1_HUMAN RNA-binding protein FXR1 (sprot)

description: An RNA-binding protein FXR1 that is encoded in the genome of human.


name: ERCC2_HUMAN General transcription and DNA repair factor IIH helicase subunit XPD (sprot)

description: A general transcription and DNA repair factor IIH helicase subunit XPD that is encoded in the genome of human.


CADH5_HUMAN Cadherin-5 (sprot)

A cadherin-5 that is encoded in the genome of human.


name: PTPRB_HUMAN Receptor-type tyrosine-protein phosphatase beta (sprot)

description: A receptor-type tyrosine-protein phosphatase beta that is encoded in the genome of human.


OLTIPRAZ

A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.


name: KISS1_HUMAN Metastasis-suppressor KiSS-1 (sprot)

description: A metastasis-suppressor KiSS-1 that is encoded in the genome of human.


methylprednisolone

The 6alpha-stereoisomer of  6-methylprednisolone.


mixed connective tissue disease

description: Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus, scleroderma, and polymyositis. Some affected people may also have symptoms of rheumatoid arthritis. Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon ; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppresivedrugsmay help manage the symptoms.


name: PNKD_HUMAN Probable hydrolase PNKD (sprot)

description: A probable hydrolase PNKD that is encoded in the genome of human.


idelalisib

A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indolent non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.


name: SHIP1_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (sprot)

description: A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 that is encoded in the genome of human.


ritodrine

A 4-[2-[[1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol that has (1S,2R)-configuration.


Hypocalcemia

description: An abnormally decreased calcium concentration in the blood.


name: LAMP1_HUMAN Lysosome-associated membrane glycoprotein 1 (sprot)

description: A lysosome-associated membrane glycoprotein 1 that is encoded in the genome of human.


name: DPYL2_HUMAN Dihydropyrimidinase-related protein 2 (sprot)

description: A dihydropyrimidinase-related protein 2 that is encoded in the genome of human.


guanine

A 2-aminopurine carrying a 6-oxo substituent.


MYP0_HUMAN Myelin protein P0 (sprot)

A myelin P0 protein that is encoded in the genome of human.


ellagic acid

An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates.


demyelinating disease

description: A broad group of disorders that affect the myelin sheaths that cover the neurons. Myelin sheathes cover neuronal axons in the central and peripheral nervous system and function to increase traveling impulse speeds. Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others.


name: LMIP_HUMAN Lens fiber membrane intrinsic protein (sprot)

description: A lens fiber membrane intrinsic protein that is encoded in the genome of human.


primary biliary cholangitis

description: Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.


name: CH3L1_HUMAN Chitinase-3-like protein 1 (sprot)

description: A chitinase-3-like protein 1 that is encoded in the genome of human.


spironolactone

A  steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.


hypereosinophilic syndrome

description: Hypereosinophilic syndrome (HES) constitutes a rare and heterogeneous group of disorders, defined as persistent and marked blood eosinophilia and/or tissue eosinophilia associated with a wide range of clinical manifestations reflecting eosinophil-induced tissue/organ damage.


name: JUND_HUMAN Transcription factor JunD (sprot)

description: A transcription factor JunD that is encoded in the genome of human.


name: GPX3_HUMAN Glutathione peroxidase 3 (sprot)

description: A glutathione peroxidase 3 that is encoded in the genome of human.


name: NCKX3_HUMAN Sodium/potassium/calcium exchanger 3 (sprot)

description: A sodium/potassium/calcium exchanger 3 that is encoded in the genome of human.


lung adenocarcinoma

description: A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor.


name: ARGI2_HUMAN Arginase-2, mitochondrial (sprot)

description: An arginase-2, mitochondrial that is encoded in the genome of human.


name: AAPK2_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-2 (sprot)

description: A 5'-AMP-activated protein kinase catalytic subunit alpha-2 that is encoded in the genome of human.


name: NPCL1_HUMAN NPC1-like intracellular cholesterol transporter 1 (sprot)

description: An NPC1-like intracellular cholesterol transporter 1 that is encoded in the genome of human.


name: SRFB1_HUMAN Serum response factor-binding protein 1 (sprot)

description: A serum response factor-binding protein 1 that is encoded in the genome of human.


name: B3GA1_HUMAN Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (sprot)

description: A galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 that is encoded in the genome of human.


schizophrenia

description: A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality.


name: LRP5_HUMAN Low-density lipoprotein receptor-related protein 5 (sprot)

description: A low-density lipoprotein receptor-related protein 5 that is encoded in the genome of human.


name: STK40_HUMAN Serine/threonine-protein kinase 40 (sprot)

description: A serine/threonine-protein kinase 40 that is encoded in the genome of human.


name: RL27A_HUMAN Large ribosomal subunit protein uL15 (sprot)

description: A eukaryotic-type large ribosomal subunit protein uL15 that is encoded in the genome of human.


Hyporeflexia

description: Reduction of neurologic reflexes such as the knee-jerk reaction.


name: MOG_HUMAN Myelin-oligodendrocyte glycoprotein (sprot)

description: A myelin-oligodendrocyte glycoprotein that is encoded in the genome of human.


name: I5P1_HUMAN Inositol polyphosphate-5-phosphatase A (sprot)

description: An inositol polyphosphate-5-phosphatase A that is encoded in the genome of human.


name: KLF1_HUMAN Krueppel-like factor 1 (sprot)

description: A krueppel-like factor 1 that is encoded in the genome of human.


name: RBM5_HUMAN RNA-binding protein 5 (sprot)

description: An RNA-binding protein 5 that is encoded in the genome of human.


name: SOX5_HUMAN Transcription factor SOX-5 (sprot)

description: A transcription factor SOX-5 that is encoded in the genome of human.


posaconazole

An N-arylpiperazine that consists of piperazine carrying two 4-substituted phenyl groups at positions 1 and 4. A triazole antifungal drug.


streptozocin

An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.


name: CAVN2_HUMAN Caveolae-associated protein 2 (sprot)

description: A caveolae-associated protein 2 that is encoded in the genome of human.


STIGMASTEROL

A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.


obstructive sleep apnea syndrome

description: Cessation of air flow during sleep due to upper airway obstruction.


L-threonine

An optically active form of threonine having L-configuration.


EREG_HUMAN Proepiregulin (sprot)

A proepiregulin that is encoded in the genome of human.


name: NCHL1_HUMAN Neural cell adhesion molecule L1-like protein (sprot)

description: A neural cell adhesion molecule L1-like protein that is encoded in the genome of human.


ampicillin

A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.


gram-positive bacterial infections

description: Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.


cortisone

A C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20.


osteoarthritis, knee

description: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)


ITA6_HUMAN Integrin alpha-6 (sprot)

An integrin alpha-6 that is encoded in the genome of human.


name: CRHBP_HUMAN Corticotropin-releasing factor-binding protein (sprot)

description: A corticotropin-releasing factor-binding protein that is encoded in the genome of human.


cutaneous melanoma

description: A primary melanoma arising from atypical melanocytes in the skin. Precursor lesions include acquired and congenital melanocytic nevi, and dysplastic nevi. Several histologic variants have been recognized, including superficial spreading melanoma, acral lentiginous melanoma, nodular melanoma, and lentigo maligna melanoma.


fondaparinux

A synthetic pentasaccharide which, apart from the O-methyl group at the reducing end of the molecule, consists of monomeric sugar units which are identical to a sequence of five monomeric sugar units that can be isolated after either chemical or enzymatic cleavage of the polymeric glycosaminoglycans heparin and heparan sulfate.


name: MICU1_HUMAN Calcium uptake protein 1, mitochondrial (sprot)

description: A calcium uptake protein 1, mitochondrial that is encoded in the genome of human.


name: MED12_HUMAN Mediator of RNA polymerase II transcription subunit 12 (sprot)

description: A mediator of RNA polymerase II transcription subunit 12 that is encoded in the genome of human.


name: RPB4_HUMAN DNA-directed RNA polymerase II subunit RPB4 (sprot)

description: A DNA-directed RNA polymerase II subunit RPB4 that is encoded in the genome of human.


IL11_HUMAN Interleukin-11 (sprot)

An interleukin-11 that is encoded in the genome of human.


phosphatidylethanolamine (P-16:0/20:4)

A phosphatidylethanolamine P-36:4 in which the 1-alkenyl group contains 16 carbons and no additional double bonds while the acyl group contains 20 carbons and 4 double bonds.


thrombotic disease

description: The formation of a blood clot in the lumen of a vessel or heart chamber; causes include coagulation disorders and vascular endothelial injury.


malabsorption syndrome

description: A syndrome resulting from the inadequate absorption of nutrients in the small intestine. Symptoms include abdominal pain, bloating, and diarrhea.


ARRB2_HUMAN Beta-arrestin-2 (sprot)

A beta-arrestin-2 that is encoded in the genome of human.


name: TBR1_HUMAN T-box brain protein 1 (sprot)

description: A T-box brain protein 1 that is encoded in the genome of human.


name: UN45A_HUMAN Protein unc-45 homolog A (sprot)

description: A protein unc-45 homolog A that is encoded in the genome of human.


name: ARF6_HUMAN ADP-ribosylation factor 6 (sprot)

description: An ADP-ribosylation factor 6 that is encoded in the genome of human.


IgG4-related pachymeningitis

description: Idiopathic hypertrophic pachymeningitis (IHP) is a rare disorder causing inflammation and thickening of the outer layer (dura) of the brain and/or spinal cord. IHP can be widespread or cause tumor-like lesions. Before IHP can be diagnosed, other conditions including sarcoidosis, tumors, meningioma, infections (syphilis, tuberculosis, and Lyme disease), and autoimmune diseases (rheumatoid arthritis, Sjogrenbs syndrome, Wegenerbs granulomatosis, and IgG4-related disease) must be ruled out. IHP often presents with headache and cranial nerve impairment. Treatment may involve prednisone and/or an immune suppressing drug. This treatment often improves symptoms, however complete recovery is rare. Surgery may be recommended for people with advanced or severe IHP. Some people with IHP have no symptoms and may not need treatment.


LIMK1_HUMAN LIM domain kinase 1 (sprot)

A LIM domain kinase 1 that is encoded in the genome of human.


name: SSH1_HUMAN Protein phosphatase Slingshot homolog 1 (sprot)

description: A protein phosphatase Slingshot homolog 1 that is encoded in the genome of human.


Hepatosplenomegaly

description: Simultaneous enlargement of the liver and spleen.


STX1B_HUMAN Syntaxin-1B (sprot)

A syntaxin-1B that is encoded in the genome of human.


name: LRWD1_HUMAN Leucine-rich repeat and WD repeat-containing protein 1 (sprot)

description: A leucine-rich repeat and WD repeat-containing protein 1 that is encoded in the genome of human.


name: SV2B_HUMAN Synaptic vesicle glycoprotein 2B (sprot)

description: A synaptic vesicle glycoprotein 2B that is encoded in the genome of human.


name: GHRL_HUMAN Appetite-regulating hormone (sprot)

description: An appetite-regulating hormone that is encoded in the genome of human.


name: IRF4_HUMAN Interferon regulatory factor 4 (sprot)

description: An interferon regulatory factor 4 that is encoded in the genome of human.


name: HDAC7_HUMAN Histone deacetylase 7 (sprot)

description: A histone deacetylase 7 that is encoded in the genome of human.


IL10_HUMAN Interleukin-10 (sprot)

An interleukin-10 that is encoded in the genome of human.


name: SFPA2_HUMAN Pulmonary surfactant-associated protein A2 (sprot)

description: A pulmonary surfactant-associated protein A2 that is encoded in the genome of human.


topiramate

A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine.


name: ZN503_HUMAN Zinc finger protein 503 (sprot)

description: A zinc finger protein 503 that is encoded in the genome of human.


name: TRI14_HUMAN Tripartite motif-containing protein 14 (sprot)

description: A tripartite motif-containing protein 14 that is encoded in the genome of human.


description: A disease caused by infection with severe acute respiratory syndrome coronavirus 2.


tilarginine

A L-arginine derivative with a N(omega)-methyl substituent.


EPO_HUMAN Erythropoietin (sprot)

An erythropoietin that is encoded in the genome of human.


name: ETV1_HUMAN ETS translocation variant 1 (sprot)

description: An ETS translocation variant 1 that is encoded in the genome of human.


name: C1QT1_HUMAN Complement C1q tumor necrosis factor-related protein 1 (sprot)

description: A complement C1q tumor necrosis factor-related protein 1 that is encoded in the genome of human.


name: LIMD2_HUMAN LIM domain-containing protein 2 (sprot)

description: A LIM domain-containing protein 2 that is encoded in the genome of human.


ixazomib

A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixazomib citrate, it is used in combination therapy for treatment of multiple myeloma.


name: MMP8_HUMAN Neutrophil collagenase (sprot)

description: A neutrophil collagenase that is encoded in the genome of human.


LAPACHONE

A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.


Dyskinesia

description: A movement disorder which consists of effects including diminished voluntary movements and the presence of involuntary movements.


Alzheimer disease

description: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.


taurolidine

A member of the class of thiadiazinanes that is 1,2,4-thiadiazinane 1,1-dioxide substituted by a (1,1-dioxido-1,2,4-thiadiazinan-4-yl)methyl group at position 4. It is a broad-spectrum antiseptic used as lock therapy solution in patients with long term central venous catheters for the prevention of catheter related bloodstream infections.


carcinoma of esophagus

description: Esophageal carcinoma (EC) is a tumor arising in the epithelial cells lining the esophagus and can be divided into two subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC).


Tourette syndrome

description: A neurologic disorder caused by defective metabolism of the neurotransmitters in the brain. It is characterized by repeated involuntary movements (motor tics) and uncontrollable vocal sounds (vocal tics). The symptoms are usually manifested before the age of eighteen.


PODXL_HUMAN Podocalyxin (sprot)

A podocalyxin-like protein 1 that is encoded in the genome of human.


name: RNPS1_HUMAN RNA-binding protein with serine-rich domain 1 (sprot)

description: An RNA-binding protein with serine-rich domain 1 that is encoded in the genome of human.


cytarabine

A pyrimidine nucleoside in which cytosine is attached to D-arabinofuranose via a beta-N(1)-glycosidic bond. Used mainly in the treatment of leukaemia, especially acute non-lymphoblastic leukaemia, cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. It also has antiviral and immunosuppressant properties.


canine lymphoma

description: A malignant lymphoproliferative disorder that affects dogs. It is characterized by the clonal proliferation of B- or T-lymphocytes in the lymph nodes, bone marrow, and/or extranodal sites.


itraconazole

An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.


Niemann-Pick disease, type C1

description: Type C Niemann-Pick disease associated with a mutation in the gene NPC1, encoding Niemann-Pick C1 protein.


eugenol

A phenylpropanoid formally derived from guaiacol with an allyl chain substituted para to the hydroxy group. It is a major component of clove essential oil, and exhibits antibacterial, analgesic and antioxidant properties. It has been widely used in dentistry to treat toothache and pulpitis.


name: NLRC4_HUMAN NLR family CARD domain-containing protein 4 (sprot)

description: An NLR family CARD domain-containing protein 4 that is encoded in the genome of human.


name: HSPB8_HUMAN Heat shock protein beta-8 (sprot)

description: A heat shock protein beta-8 that is encoded in the genome of human.


MENAQUINONE 7

A menaquinone whose side-chain contains seven isoprene units in an all-trans-configutation.


IONOMYCIN

A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2',5-dimethyloctahydro-2,2'-bifuran-5-yl)ethanol group at position 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes.


central serous chorioretinopathy

description: Central serous chorioretinopathy is a disease that causes fluid to build up under the retina, the back part of the inner eye that sends sight information to the brain. The fluid leaks from thechoroid (theblood vessel layer under the retina). The cause of this condition is unknown but stress can be a risk factor. Signs and symptoms include dim and blurred blind spot in the center of vision, distortion of straight linesand seeingobjectsas smaller or farther away. Many cases of central serous chorioretinopathy improve without treatment after 1-2 months. Laser treatment may be an option for other individuals.


name: PDC10_HUMAN Programmed cell death protein 10 (sprot)

description: A programmed cell death protein 10 that is encoded in the genome of human.


name: ASB4_HUMAN Ankyrin repeat and SOCS box protein 4 (sprot)

description: An ankyrin repeat and SOCS box protein 4 that is encoded in the genome of human.


name: MAVS_HUMAN Mitochondrial antiviral-signaling protein (sprot)

description: A mitochondrial antiviral-signaling protein that is encoded in the genome of human.


name: RNF11_HUMAN RING finger protein 11 (sprot)

description: A RING finger protein 11 that is encoded in the genome of human.


VALPROATE SODIUM

The sodium salt of valproic acid.


name: Z518B_HUMAN Zinc finger protein 518B (sprot)

description: A zinc finger protein 518B that is encoded in the genome of human.


name: RAD17_HUMAN Cell cycle checkpoint protein RAD17 (sprot)

description: A cell cycle checkpoint protein RAD17 that is encoded in the genome of human.


name: RA51B_HUMAN DNA repair protein RAD51 homolog 2 (sprot)

description: A DNA repair protein RAD51 homolog 2 that is encoded in the genome of human.


name: Premature coronary artery atherosclerosis

description: Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries before age of 45.


L-glutamic acid

An optically active form of glutamic acid having L-configuration.


name: SMAD3_HUMAN Mothers against decapentaplegic homolog 3 (sprot)

description: A smad3 that is encoded in the genome of human.


salicylic acid

A monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves.