Stage II Rectosigmoid Cancer AJCC v6

description: Stage II includes IIA (T3, N0, M0) and IIB (T4, N0, M0). T3: Tumor invades through the muscularis propria into the subserosa, or into nonperitonealized pericolic or perirectal tissues. T4: Tumor directly invades other organs or structures, and/or perforates the visceral peritoneum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Unresectable Colorectal Carcinoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A colorectal carcinoma that is not amenable to surgical resection.


Stage IV Colorectal Cancer AJCC v6

description: Stage IV includes: Any T, any N, M1.  M1: Distant metastasis. (AJCC 6th ed.)


name: Colorectal L-Cell Glucagon-Like Peptide-Producing Neuroendocrine Tumor

description: A neuroendocrine tumor that arises from the colon or rectum and produces glucagon-like peptides.  Morphologically, it is characterized by the presence of neoplastic cells forming tubular or trabecular patterns.


Stage III Colorectal Cancer AJCC v7

description: Stage III includes: IIIA (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  N1: Metastasis in 1-3 regional lymph nodes.  N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2: Metastasis in four or more regional lymph nodes.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIIC Colon Cancer AJCC v7

description: Stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor penetrates to the surface of the visceral peritoneum. T4b: Tumor directly invades or is adherent to other organs or structures. N1: Metastasis in 1-3 regional lymph nodes. N2: Metastasis in four or more regional lymph nodes. N2a: Metastasis in 4-6 regional lymph nodes. N2b: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


name: Recurrent Microsatellite Stable Colorectal Carcinoma

description: The reemergence of microsatellite stable colorectal carcinoma after a period of remission.


name: Colon Cribriform Comedo-Type Adenocarcinoma

description: A rare, invasive colon adenocarcinoma characterized by the presence of malignant cribriform glands with central necrotic changes.


Proximal Colon Carcinoma

description: A colon carcinoma that arises from cecum, ascending colon, or hepatic flexure.


name: Colorectal Mucin Poor Hyperplastic Polyp

description: A serrated hyperplastic polyp that arises from the colon and rectum.  It is characterized by the presence of small cells in the crypts that do not contain mucin.  Reactive epithelial atypia may be present.


Rectosigmoid Signet Ring Cell Carcinoma

description: An infiltrating adenocarcinoma arising from the rectosigmoid area.  It is characterized by the presence of malignant glandular cells with prominent intracytoplasmic mucin.  These cells constitute more than 50% of the malignant cellular population.


Stage IIIB Rectal Cancer AJCC v7

description: Stage IIIB includes: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0). T1: Tumor invades submucosa. T2: Tumor invades muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor penetrates to the surface of the visceral peritoneum. N1: Metastasis in 1-3 regional lymph nodes. N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2a: Metastasis in 4-6 regional lymph nodes. N2b: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Jejunal Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the jejunum. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Stage IIA Rectal Cancer AJCC v7

description: Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage I Small Intestinal Adenocarcinoma AJCC v8

description: Stage I includes: T1-2, N0, M0. T1: Tumor invading the lamina propria or submucosa. T2: Tumor invading the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Jejunal ulcer

description: A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the jejunum.


name: Refractory Microsatellite Stable Colorectal Carcinoma

description: Microsatellite stable colorectal carcinoma that is resistant to treatment.


Stage IIB Colon Cancer AJCC v8

description: Stage IIB includes: T4a, N0, M0. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Colon Micropapillary Adenocarcinoma

description: A rare, invasive colon adenocarcinoma characterized by the presence of clusters of malignant glandular cells within stromal spaces.


Stage IV Rectosigmoid Cancer AJCC v6

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th ed.)


name: Stage III Jejunal Neuroendocrine Tumor AJCC v8

description: Stage III includes: (T1, N1, N2, M0); (T2, N1, N2, M0); (T3, N1, N2, M0); (T4, N0, M0); (T4, N1, N2, M0). T1: Tumor invading lamina propria or submucosa and measuring 1 cm or less in size. T2: Tumor invading muscularis propria or measuring more than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis in less than 12 nodes. N2: Large mesenteric masses (larger than 2 cm) and/or extensive nodal deposits (12 or greater), especially those that encase the superior mesenteric vessels. M0: No distant metastasis. (AJCC 8th ed.)


Adenocarcinoma of colon recurrent

description: The reemergence of colon adenocarcinoma after a period of remission.


name: Crohn Disease-Associated Colorectal Adenocarcinoma

description: A colorectal adenocarcinoma that develops in patients with a history of Crohn disease.


Colorectal Villous Adenoma

description: A neoplasm that arises from the glandular epithelium of the colonic and rectal mucosa. It is characterized by a villous architectural pattern. The neoplastic glandular cells have dysplastic features.


Rectal Adenoma with Severe Dysplasia

description: An adenoma that arises from the rectum.  It is characterized by the presence of severe epithelial dysplasia.


Colorectal Ganglioneuroma

description: A ganglioneuroma that arises from the colon or rectum.  It usually presents as a small mucosal polyp.


name: Stage IIIA Small Intestinal Adenocarcinoma AJCC v8

description: Stage IIIA includes: Any T, N1, M0. N1: Metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Adenocarcinoma of colon metastatic

description: An adenocarcinoma that arises from the colon and has metastasized to another anatomic site.


Stage IIB Colorectal Cancer AJCC v7

description: Stage IIB includes: T4a, N0, M0.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Gastrointestinal stromal tumor of small intestine

description: A gastrointestinal stromal tumor that arises from the small intestine.  It usually affects adults over fifty years of age.  The majority of cases have spindle cell morphology.  The prognosis depends on the tumor size and the mitotic activity.


Rectal Micropapillary Adenocarcinoma

description: A rare, invasive rectal adenocarcinoma characterized by the presence of clusters of malignant glandular cells within stromal spaces.


Infectious Enterocolitis

description: An infectious process affecting the small and large intestines. Symptoms include diarrhea, cramping abdominal pain, and fever.


name: Locally Advanced Microsatellite Stable Colorectal Carcinoma

description: A microsatellite stable colorectal carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Rectal Serrated Adenocarcinoma

description: A rare, invasive rectal adenocarcinoma characterized by the presence of a malignant infiltrate with serrated glandular architecture.


Advanced Rectal Carcinoma

description: Rectal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Colon Ganglioneuroma

description: A ganglioneuroma that arises from the colon.  It usually presents as a small mucosal polyp.


Unresectable Colorectal Adenocarcinoma

description: Colorectal adenocarcinoma that is not amenable to surgical resection.


name: Colorectal Goblet Cell Rich Hyperplastic Polyp

description: A serrated hyperplastic polyp that arises from the colon and rectum.  It is characterized by the presence of goblet cells and the absence of microvacuolated columnar cells.  There is no evidence of epithelial atypia or dysplasia.


Stage IIA Rectal Cancer AJCC v8

description: Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Colorectal Mucinous Adenocarcinoma

description: An invasive colorectal adenocarcinoma characterized by the presence of extracellular mucin pools that contain malignant glandular epithelial structures.  The extracellular mucin pools occupy more than 50% of the malignant lesion.


Colorectal Cancer by AJCC v8 Stage

description: A term that refers to the staging of colorectal cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to adenocarcinomas, high-grade neuroendocrine carcinomas, and squamous cell carcinomas of the colon and rectum. Appendiceal carcinomas, anal carcinomas, and well-differentiated neuroendocrine tumors (carcinoids) are not covered by this staging system. (from AJCC 8th Ed.)


Stage IIIB Colorectal Cancer AJCC v7

description: Stage IIIB includes: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0). T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  N1: Metastasis in 1-3 regional lymph nodes.  N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Small intestine carcinoma stage IV

description: Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 7th ed.)


Stage IIA Colon Cancer AJCC v7

description: Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Colorectal Sarcomatoid Carcinoma

description: A biphasic colorectal carcinoma with a spindle cell, sarcomatoid component.


Stage IIB Rectal Cancer AJCC v7

description: Stage IIB includes: T4a, N0, M0. T4a: Tumor penetrates to the surface of the visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Colorectal Cancer by AJCC v7 Stage

description: A term that refers to the staging of colorectal carcinoma according to the American Joint Committee on Cancer, 7th edition.


name: Metastatic malignant neoplasm to large intestine

description: The spread of a malignant neoplasm to the large intestine.  This may be from a primary large intestine malignant neoplasm, or from a malignant neoplasm at a distant site.


Crohn's disease of small intestine

description: Crohn's disease affecting the small intestine.


Descending Colon Neuroendocrine Tumor

description: A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the descending colon.


Refractory Rectal Carcinoma

description: Rectal carcinoma that is resistant to treatment.


name: Stage IIIB Small Intestinal Adenocarcinoma AJCC v8

description: Stage IIIB includes: Any T, N2, M0. N2: Metastasis in three or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Rectal Juvenile Polyp

description: A non-neoplastic hamartomatous polyp that arises from the rectum.  It is characterized by the presence of tortuous and cystically dilated glands, edematous changes, and inflammation.


name: Descending Colon Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the descending colon. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Intestinal Soft Tissue Neoplasm

description: A benign, intermediate, or malignant mesenchymal neoplasm that arises from the small or large intestine.


Colorectal Undifferentiated Carcinoma

description: An invasive malignant epithelial tumor that arises from the colon or rectum.  There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation.


Stage IIA Colon Cancer AJCC v8

description: Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Rectal Serrated Lesions and Polyps

description: Polyps that arises from the rectum. They are characterized by the presence of serrated glands and the absence of generalized dysplasia.


Transverse Colon Neuroendocrine Tumor

description: A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the transverse colon.


Colon cancer recurrent

description: The reemergence of colon carcinoma after a period of remission.


Metastatic Colorectal Adenocarcinoma

description: Colorectal adenocarcinoma that has spread from the original site of growth to other anatomic sites.


Colon Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the colon. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Stage IV Colorectal Cancer AJCC v8

description: Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b); IVC: (Any T, Any N, M1c). M1a: Metastasis to one site or organ without peritoneal metastasis. M1b: Metastasis to two or more sites or organs without peritoneal metastasis. M1c: Metastasis to the peritoneal surface alone or with other site or organ metastases. (AJCC 8th ed.)


name: Ileal Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of an ileal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This classification system applies to small bowel "carcinoid" tumors (NET G1 and G2, and rare well-differentiated G3) arising in the ileum. This classification system does not apply to high-grade neuroendocrine carcinomas, mixed adenoneuroendocrine carcinomas, and neuroendocrine tumors of the duodenum. (from AJCC 8th Ed.)


Lipoma of small intestine

description: A rare benign adipose tissue neoplasm of the small intestine.  It usually arises from the submucosa and occasionally protrudes into the lumen.


Refractory Colorectal Adenocarcinoma

description: Colorectal adenocarcinoma that is resistant to treatment.


Stage IIIC Colorectal Cancer AJCC v8

description: Stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Anaplastic Carcinoma of the Rectum

description: An invasive malignant epithelial tumor that arises from the rectum.  There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation.


Stage II Rectal Cancer

description: Stage II includes IIA (T3, N0, M0) and IIB (T4, N0, M0). T3: Tumor invades through the muscularis propria into the subserosa, or into nonperitonealized pericolic or perirectal tissues. T4: Tumor directly invades other organs or structures, and/or perforates the visceral peritoneum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Stage IIIA Rectal Cancer AJCC v7

description: Stage IIIA includes: (T1-T2, N1/N1c, M0); (T1, N2a, M0). T1: Tumor invades submucosa. T2: Tumor invades muscularis propria. N1: Metastasis in 1-3 regional lymph nodes. N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2a: Metastasis in 4-6 regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Colorectal Peutz-Jeghers Polyp

description: A non-neoplastic hamartomatous polyp that arises from the colon and rectum.  It is characterized by the presence of smooth muscle branching bands, and cystic mucosal changes.


name: Metastatic malignant neoplasm to small intestine

description: A malignant neoplasm that has spread to the small intestine from another anatomic site.


name: Small Intestinal Signet Ring Cell Carcinoma

description: An invasive adenocarcinoma that arises from the small intestine.  It is characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus.


Stage IVA Colon Cancer AJCC v8

description: Stage IVA includes: Any T, Any N, M1a. M1a: Metastasis to one site or organ without peritoneal metastasis. (AJCC 8th ed.)


name: Stage I Jejunal Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invading lamina propria or submucosa and measuring 1 cm or less in size. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Duodenal cancer recurrent

description: The reemergence of a malignant duodenal neoplasm after a period of remission.


Locally Advanced Rectal Carcinoma

description: Rectal carcinoma that has spread to nearby tissues or lymph nodes.


Stage IIA Colorectal Cancer AJCC v7

description: Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into pericolorectal tissues.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Ulcerative Colitis Flare

description: An exacerbation of ulcerative colitis.


Stage III Rectosigmoid Cancer AJCC v7

description: Stage III includes: IIIA (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N1: Metastasis in 1-3 regional lymph nodes.  N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2: Metastasis in four or more regional lymph nodes.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Stage III Colorectal Cancer AJCC v8

description: Stage III includes: IIIA: (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Intestinal Neuroendocrine Tumor

description: A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the small or large intestine.


name: Rectal Small Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the rectum.  It is characterized by the presence of malignant small cells.


Sigmoid Colon Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the sigmoid colon. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


name: Stage 0 Colorectal Cancer AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial or invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Colitis due to radiation

description: Inflammation of the colon resulting from irradiation.


Grade 3 Rectal Adenocarcinoma

description: A rectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with less than 50% glandular formation.


Microsatellite Stable Rectal Carcinoma

description: Rectal carcinoma characterized by the absence of microsatellite instability.


Colorectal Tubular Adenoma

description: A usually polypoid neoplasm that arises from the glandular epithelium of the colonic and rectal mucosa. It is characterized by a tubular architectural pattern. The neoplastic glandular cells have dysplastic features.


Stage I Colorectal Cancer AJCC v8

description: Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage III Rectal Cancer AJCC v6

description: Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.)


name: Stage III Duodenal Neuroendocrine Tumor AJCC v8

description: Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor invading the visceral peritoneum (serosa) or other organs. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Oligometastatic Colorectal Carcinoma

description: Colorectal carcinoma that has metastasized to a limited number of sites.


name: Stage IIA Small Intestinal Adenocarcinoma AJCC v8

description: Stage IIA includes: T3, N0, M0. T3: Tumor invading through the muscularis propria into the subserosa, or extending into nonperitonealized perimuscular tissue (mesentery or retroperitoneum) without serosal penetration. For T3 tumors, the nonperitonealized perimuscular tissue is, for the jejunum and ileum, part of the mesentery and, for the duodenum in areas where serosa is lacking, part of the interface with the pancreas. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Locally Advanced Microsatellite Stable Colon Carcinoma

description: Microsatellite stable colon carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage IV Duodenal Neuroendocrine Tumor AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Ileal Web

description: The formation of tissue in the lumen of the ileum that results in partial obstruction.


Stage IVC Colorectal Cancer AJCC v8

description: Stage IVC includes: Any T, Any N, M1c. M1c: Metastasis to the peritoneal surface alone or with other site or organ metastases. (AJCC 8th ed.)


Short segment Hirschsprung's disease

description: The most common form of Hirschsprung Disease, this is characterized by a lack of nerve cells in the sigmoid colon and rectum. The bowel is not stimulated without innervation and obstruction ensues. Surgical intervention is necessary.


Colorectal Adenoma-Like Adenocarcinoma

description: A well differentiated colorectal adenocarcinoma with good prognosis. It resembles a villous adenoma on the surface.


Colorectal Schwannoma

description: A schwannoma that arises from the colon or rectum.  It may cause gastrointestinal bleeding and luminal obstruction.


name: Stage I Rectosigmoid Cancer AJCC v6 and v7

description: Stage I includes: (T1, N0, M0); (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Ascending Colon Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the ascending colon. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Stage IV Colon Cancer AJCC v8

description: Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b); IVC: (Any T, Any N, M1c). M1a: Metastasis to one site or organ without peritoneal metastasis. M1b: Metastasis to two or more sites or organs without peritoneal metastasis. M1c: Metastasis to the peritoneal surface alone or with other site or organ metastases. (AJCC 8th ed.)


Small Intestinal Villous Adenoma

description: A neoplasm that arises from the glandular epithelium of the small intestine. It is characterized by a villous architectural pattern. The neoplastic glandular cells have dysplastic features.


name: Stage IIIA Small Intestinal Gastrointestinal Stromal Tumor

description: Stage IIIA includes: (T1, N0, M0, Mitotic rate: High); (T4, N0, M0, Mitotic rate: Low).  T1: Tumor 2 cm or less in greatest dimension.  T4: Tumor more than 10 cm in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Rectal Gastrointestinal Stromal Tumor

description: Gastrointestinal stromal tumor that arises from the rectum.


Colorectal cancer recurrent

description: The reemergence of colorectal carcinoma after a period of remission.


name: Colon Enterochromaffin Cell Serotonin-Producing Neuroendocrine Tumor

description: A well differentiated neuroendocrine tumor that arises from the colon and produces serotonin.


Stage IIIB Colon Cancer AJCC v7

description: Stage IIIB includes: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0). T1: Tumor invades submucosa. T2: Tumor invades muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor penetrates to the surface of the visceral peritoneum. N1: Metastasis in 1-3 regional lymph nodes. N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2a: Metastasis in 4-6 regional lymph nodes. N2b: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Stage III Colon Cancer AJCC v7

description: Stage III includes: IIIA (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  N1: Metastasis in 1-3 regional lymph nodes.  N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2: Metastasis in four or more regional lymph nodes.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Duodenal carcinoma recurrent

description: The reemergence of duodenal carcinoma after a period of remission.


Ileal Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the ileum. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


name: Transverse Colon Neuroendocrine Tumor G1

description: A well differentiated, low grade neuroendocrine neoplasm that arises from the transverse colon. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Stage IIIC Colorectal Cancer AJCC v7

description: Stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0).  T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N1: Metastasis in 1-3 regional lymph nodes.  N2: Metastasis in four or more regional lymph nodes.  N2a: Metastasis in 4-6 regional lymph nodes.  N2b: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Small Intestinal Angiosarcoma

description: An angiosarcoma that arises from the small intestine.


Stage IVA Rectal Cancer AJCC v7

description: Stage IVA includes: Any T, Any N, M1a. M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node). (AJCC 7th ed.)


Stage IIC Rectal Cancer AJCC v8

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Locally Advanced Colorectal Adenocarcinoma

description: Colorectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


description: A rare, invasive colorectal adenocarcinoma characterized by the presence of clusters of malignant glandular cells within stromal spaces.


Secondary malignant neoplasm of rectum

description: The spread of a malignant neoplasm to the rectum.  This may be from a primary large intestine malignant neoplasm, or from a malignant neoplasm at a distant site.


Stage IIB Colon Cancer AJCC v7

description: Stage IIB includes: T4a, N0, M0. T4a: Tumor penetrates to the surface of the visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage I Duodenal Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invading the mucosa or submucosa only and is equal or less than 1 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Rectosigmoid Adenocarcinoma

description: An adenocarcinoma arising from the rectosigmoid area.  It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease.  Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits.  According to the degree of cellular differentiation, rectosigmoid adenocarcinomas are divided into well, moderately, and poorly differentiated.  Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.


Metastatic Colorectal Carcinoma

description: A carcinoma that arises from the colon or rectum and has metastasized to another anatomic site.


Stage IV Rectal Cancer AJCC v6

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th ed.)


name: Stage I Small Intestinal Gastrointestinal Stromal Tumor

description: Stage I includes: T1 or T2, N0, M0, Mitotic rate: Low.  T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm, but not more than 5 cm, in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Advanced Colon Carcinoma

description: Colon carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage III Rectal Cancer AJCC v8

description: Stage III includes: IIIA: (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IIIB Small Intestinal Gastrointestinal Stromal Tumor

description: Stage IIIB includes: (T2, N0, M0, Mitotic rate: High); (T3, N0, M0, Mitotic rate: High); (T4, N0, M0, Mitotic rate: High).  T2: Tumor more than 2 cm, but not more than 5 cm, in greatest dimension. T3: Tumor more than 5 cm, but not more than 10 cm, in greatest dimension. T4: Tumor more than 10 cm in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Colon Cancer by AJCC v6 Stage

description: A term that refers to the staging of colon carcinoma according to the American Joint Committee on Cancer, 6th edition.


Small intestine carcinoma recurrent

description: The reemergence of small intestine carcinoma after a period of remission.


name: Rectal Cribriform Comedo-Type Adenocarcinoma

description: A rare, invasive rectal adenocarcinoma characterized by the presence of malignant cribriform glands with central necrotic changes.


name: Stage IIIB Small Intestinal Cancer AJCC v7

description: Stage IIIB includes: Any T, N2, M0. N2: Metastasis in four or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Meckel Diverticulum Neuroendocrine Tumor G1

description: A well differentiated, low grade neuroendocrine neoplasm that arises in a Meckel diverticulum.


Stage IV Rectal Cancer AJCC v8

description: Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b); IVC: (Any T, Any N, M1c). M1a: Metastasis to one site or organ without peritoneal metastasis. M1b: Metastasis to two or more sites or organs without peritoneal metastasis. M1c: Metastasis to the peritoneal surface alone or with other site or organ metastases. (AJCC 8th ed.)


Colon Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the colon. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Colorectal Adenoma with Mild Dysplasia

description: An adenoma that arises from the colon or rectum.  It is characterized by the presence of mild epithelial dysplasia.


Stage IIC Colorectal Cancer AJCC v8

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Colorectal Low Grade Intraepithelial Neoplasia

description: A precancerous neoplastic process that affects the colon or rectum.  It is characterized by mild epithelial dysplasia and mild architectural alterations of the mucosal epithelium.  There is no evidence of invasion.


name: Refractory Rectal Squamous Cell Carcinoma

description: Rectal squamous cell carcinoma that is resistant to treatment.


Grade 3 Colorectal Adenocarcinoma

description: A colorectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with less than 50% glandular formation.


name: Stage II Ileal Neuroendocrine Tumor AJCC v8

description: Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor invading muscularis propria or measuring more than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Metastatic Microsatellite Stable Colorectal Carcinoma

description: A microsatellite stable carcinoma that arises from the colon or rectum and has metastasized to other anatomic sites.


Stage 0 Colorectal Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ, intramucosal carcinoma (involvement of lamina propria with no extension through muscularis mucosae). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIC Colorectal Cancer AJCC v7

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Locally Advanced Colon Carcinoma

description: Colon carcinoma that has spread to nearby tissues or lymph nodes.


Stage IVA Colorectal Cancer AJCC v8

description: Stage IVA includes: Any T, Any N, M1a. M1a: Metastasis to one site or organ without peritoneal metastasis. (AJCC 8th ed.)


name: Stage IV Jejunal Neuroendocrine Tumor AJCC v8

description: Stage IV includes: (T1, N0, N1, N2, M1); (T2, N0, N1, N2, M1); (T3, N0, N1, N2, M1); (T4, N0, N1, N2, M1). T1: Tumor invading lamina propria or submucosa and measuring 1 cm or less in size. T2: Tumor invading muscularis propria or measuring more than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis in less than 12 nodes. N2: Large mesenteric masses (larger than 2 cm) and/or extensive nodal deposits (12 or greater), especially those that encase the superior mesenteric vessels. M1: Distant metastasis. (AJCC 8th ed.)


Stage IV Rectal Cancer AJCC v7

description: Stage IV includes: IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b).  M1a: Metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node).  M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Colon Adenoma with Severe Dysplasia

description: An adenoma that arises from the colon.  It is characterized by the presence of severe epithelial dysplasia.


name: Rectal Large Cell Neuroendocrine Carcinoma

description: A rare, aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the rectum. It is characterized by the presence of malignant large cells.


name: Small Intestinal Somatostatin-Producing Neuroendocrine Tumor

description: A somatostatin-producing neuroendocrine tumor that arises from the small intestine.


name: Small Intestinal Mucinous Adenocarcinoma

description: An invasive adenocarcinoma that arises from the small intestine.  It is composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation.


name: Colorectal Poorly Cohesive Adenocarcinoma

description: An adenocarcinoma that arises from the colorectal mucosa and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates.


Intestinal Intraepithelial Neoplasia

description: A precancerous neoplastic process that affects the small or large intestine.  It is characterized by low or high grade dysplasia of the mucosal epithelium.  There is no evidence of invasion.


name: Congenital Abnormality of the Large Intestine

description: A malformation in any part of the large intestine that is present at birth.


Necrotizing Enterocolitis Totalis

description: A severe and often fatal form of necrotizing enterocolitis, in which diffuse ischemia, necrosis, and pneumatosis intestinalis are evident in the small and large intestine. Short bowel syndrome is common among survivors.


name: Stage IIB Small Intestinal Adenocarcinoma AJCC v8

description: Stage IIB includes: T4, N0, M0. T4: Tumor perforating the visceral peritoneum or directly invading other organs or structures (e.g., other loops of small intestine, mesentery of adjacent loops of bowel, and abdominal wall by way of serosa; for duodenum only, invasion of pancreas or bile duct). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Colorectal Sporadic Serrated Polyp

description: A term that refers to a group of polypoid lesions in the colon and rectum that are characterized by the presence of serrated architecture of the epithelial component.  This group includes hyperplastic polyps, traditional serrated adenomas, and sessile serrated adenomas/polyps.


Rectal Epithelioid Cell Melanoma

description: An epithelioid cell melanoma arising from the rectum.


Stage IVB Rectal Cancer AJCC v7

description: Stage IVB includes: Any T, Any N, M1b. M1b: Metastases in more than one organ/site or the peritoneum. (AJCC 7th ed.)


Undifferentiated Carcinoma of Colon

description: An invasive malignant epithelial tumor that arises from the colon.  There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation.


name: Duodenal Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of a duodenal neuroendocrine tumor according to the American Joint Committee on Cancer, 8th edition. This staging system applies to well-differentiated neuroendocrine tumors of the duodenum. Carcinomas of the duodenum, including high-grade (grade 3), poorly differentiated neuroendocrine carcinomas are not included in this staging system. (from AJCC 8th Ed.)


name: Advanced Microsatellite Stable Colorectal Carcinoma

description: A microsatellite stable carcinoma that arises from the colon or rectum and has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Jejunal Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of a jejunal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This classification system applies to small bowel "carcinoid" tumors (NET G1 and G2, and rare well-differentiated G3) arising in the jejunum. This classification system does not apply to high-grade neuroendocrine carcinomas, mixed adenoneuroendocrine carcinomas, and neuroendocrine tumors of the duodenum. (from AJCC 8th Ed.)


Juvenile Polyp of the Small Intestine

description: A non-neoplastic hamartomatous polyp that arises from the small intestine.  It is characterized by the presence of tortuous and cystically dilated glands, edematous changes, and inflammation.


Stage IIB Rectal Cancer AJCC v8

description: Stage IIB includes: T4a, N0, M0. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Large intestinal mucositis

description: An inflammatory process affecting the mucous membrane of the large intestine.


name: bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether

description: The (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) diether of bisphenol A; a small molecule that inhibits transactivation of the AR amino-terminal domain (NTD).


victoria blue B

An iminium salt composed of 4-{(4-anilinonaphthalen-1-yl)[4-(dimethylamino)phenyl]methylidene}-N,N-dimethylcyclohexa-2,5-dien-1-iminium and chloride ions in a 1:1 ratio. It binds to nucleic acids and can be used in standardised staining techniques suitable for automated cell-pattern recognition.


A member of the class of nitrosamines that is butan-1-ol substituted by a pyridin-3-yl group at position 1 and by a methyl(nitroso)amino group at position 4. It is a major metabolite of nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which is a carcinogen found in tobacco and responsible for inducing lung cancer in smokers.


oxathiolane

Any five-membered oxacycle that also contains a sulfur atom.


Variant Autoimmune Hepatitis

description: A form of autoimmune hepatitis (AIH) that has features of overlapping cholestatic autoimmune liver diseases including primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), or autoimmune cholangitis (AIC).


Childhood Paranasal Sinus Carcinoma

description: A rare carcinoma of the paranasal sinus that occurs during childhood.


Childhood Head and Neck Neoplasm

description: A benign or malignant neoplasm that affects the anatomic structures of the head and neck region and occurs during childhood.


Childhood Benign Head and Neck Neoplasm

description: A childhood neoplasm that arises from the head and neck and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Childhood Ameloblastic Fibroma

description: An ameloblastic fibroma that occurs during childhood.


Childhood Odontogenic Neoplasm

description: A benign or malignant neoplasm that arises from tooth-forming tissues and occurs during childhood.


name: Childhood Thyroid Gland Follicular Adenoma

description: A follicular adenoma of the thyroid gland that occurs during childhood.


name: Childhood Salivary Gland Mucoepidermoid Carcinoma

description: A mucoepidermoid carcinoma of the salivary gland that occurs during childhood.


Childhood Head and Neck NUT Carcinoma

description: A NUT carcinoma that arises from the head and neck and occurs during childhood.


Childhood Ameloblastoma

description: An ameloblastoma that occurs during childhood.


Childhood Salivary Gland Carcinoma

description: A rare carcinoma of the salivary gland that occurs during childhood.


Childhood Laryngeal Squamous Papilloma

description: A squamous papilloma of the larynx that occurs during childhood.


name: Childhood Salivary Gland Pleomorphic Adenoma

description: A salivary gland pleomorphic adenoma that occurs during childhood.


Childhood Nasal Cavity Carcinoma

description: A rare carcinoma of the nasal cavity that occurs during childhood.


Childhood Ossifying Fibroma

description: An ossifying fibroma that occurs during childhood.


Childhood Adenomatoid Odontogenic Tumor

description: An adenomatoid odontogenic tumor that occurs during childhood.


name: Childhood Salivary Gland Acinic Cell Carcinoma

description: An acinic cell carcinoma of the salivary gland that occurs during childhood.


Childhood Craniopharyngioma

description: A craniopharyngioma that occurs during childhood.  The vast majority of cases are adamantinomatous craniopharyngiomas.  Clinical signs and symptoms include endocrine deficiencies and visual disturbances.


Childhood Odontogenic Myxoma

description: An odontogenic myxoma that occurs during childhood.


description: An adamantinomatous craniopharyngioma that occurs during childhood.


name: Childhood Malignant Head and Neck Neoplasm

description: A malignant neoplasm that affects the anatomic structures of the head and neck region and occurs during childhood.


Childhood Mucoepidermoid Carcinoma

description: A mucoepidermoid carcinoma that occurs during childhood.


Bone Erdheim-Chester Disease

description: Erdheim-Chester disease affecting the bone.


A hydrochloride that is the monohydrochloride salt of 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol. A selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.


An ergostanoid that is (22E)-ergosta-7,22-diene substituted by hydroxy groups at positions 3 and 7 and an epoxy group across positions 5 and 6 (the 3beta,5alpha,6alpha,7alpha stereoisomer). It has been isolated from Aspergillus ochraceus as well as Penicillium commune.


A secondary fatty alcohol that is octadecane substituted by a hydroxy group at position 5.


2,4,5-TRICHLOROPHENOXYACETIC ACID

A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2, 4 and 5 are substituted by chlorines.


pyranoxanthones

Any organic heterotetracyclic compound that consists of a pyran ring fused onto a xanthone skeleton.


COCHINENSOXANTHONE

A member of the class of pyranoxanthones that is 3,4-dihydro-2H,12H-pyrano[2,3-a]xanthen-12-one substituted by hydroxy groups at positions 3, 5 and 10, geminal methyl groups at position 2 and a (2E)-3,7-dimethylocta-2,6-dien-1-yl group at position 6. It has been isolated from the stems of Cratoxylum cochinchinense.


brasixanthone D

A member of the class of pyranoxanthones that is 2H,6H-pyrano[3,2-b]xanthen-6-one substituted by a 2-[(2S)-3,3-dimethyloxiran-2-yl]-2-hydroxyethyl group at position 12, hydroxy groups at positions 5 and 8 and geminal methyl groups at position 2. It is isolated from the stem bark of Calophyllum brasiliense and exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.


Recurrent Childhood Optic Nerve Glioma

description: The reemergence of optic nerve glioma in childhood after a period of remission.


Childhood Intracranial Neoplasm

description: A neoplasm that arises within the skull and occurs during childhood.


name: Recurrent Childhood Visual Pathway Glioma

description: The reemergence of visual pathway glioma in childhood after a period of remission.


name: Childhood Supratentorial Ependymoma ZFTA Fusion-Positive

description: A supratentorial ependymoma ZFTA fusion-positive that occurs during childhood.


Childhood Supratentorial Neoplasm

description: A neoplasm that affects the supratentorial region of the brain and occurs during childhood.


Childhood Benign Brain Neoplasm

description: A childhood neoplasm that arises from the brain and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Refractory Childhood Brain Neoplasm

description: A childhood brain neoplasm that is resistant to treatment.


name: Childhood Atypical Choroid Plexus Papilloma

description: An atypical choroid plexus papilloma that occurs during childhood.


name: Childhood Pineal Parenchymal Cell Neoplasm

description: A pineal parenchymal cell neoplasm that occurs during childhood.


name: Childhood Subependymal Giant Cell Astrocytoma

description: Subependymal giant cell astrocytoma that occurs during childhood.


Childhood Gliomatosis Cerebri

description: Gliomatosis cerebri that occurs during childhood.


name: Supratentorial Ependymoma, YAP1-MAMLD1 Fusion-Positive

description: A supratentorial ependymoma characterized by a gene fusion involving YAP1 and MAMLD1 genes.


name: Metastatic Childhood Malignant Brain Neoplasm

description: A childhood malignant neoplasm that arises from the brain and has spread from its original site of growth to other anatomic sites.


name: Childhood Dysembryoplastic Neuroepithelial Tumor

description: A dysembryoplastic neuroepithelial tumor that occurs during childhood.


Recurrent Childhood Gliomatosis Cerebri

description: The reemergence of gliomatosis cerebri in childhood after a period of remission.


Recurrent Childhood Brain Neoplasm

description: The reemergence of brain neoplasm in childhood after a period of remission.


name: Childhood Pineal Parenchymal Tumor of Intermediate Differentiation

description: A pineal parenchymal tumor of intermediate differentiation that occurs during childhood.


name: Childhood Diffuse Midline Glioma, H3 K27-Altered

description: A diffuse midline glioma, H3 K27-altered that occurs during childhood.


name: Childhood Cerebral Ependymoma, Not Otherwise Specified

description: An ependymoma, not otherwise specified that arises from the cerebral hemispheres and occurs during childhood.


Childhood Brain Anaplastic Astrocytoma

description: An anaplastic astrocytoma that arises from the brain and occurs during childhood.


Childhood Brain Oligodendroglioma

description: An oligodendroglioma that arises from the brain and occurs during childhood.


Childhood Brain Glioblastoma

description: A brain glioblastoma that occurs during childhood.


Childhood Malignant Brain Neoplasm

description: A primary or metastatic malignant neoplasm affecting the brain during childhood.


name: Metastatic Childhood Malignant Neoplasm in the Brain

description: A childhood malignant neoplasm that has spread from its original site of growth to the brain.


Childhood Brain Neoplasm

description: A benign or malignant, primary or metastatic neoplasm of the brain occurring in children.


name: Childhood Benign Supratentorial Neoplasm

description: A childhood neoplasm that arises from the supratentorial region and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Childhood Multinodular and Vacuolated Neuronal Tumor

description: A multinodular and vacuolated neuronal tumor that occurs during childhood.


Childhood Cerebral Diffuse Astrocytoma

description: A diffuse astrocytoma that arises from the cerebral hemispheres and occurs during childhood.


name: Advanced Childhood Malignant Brain Neoplasm

description: A childhood malignant neoplasm that arises from the brain and has spread extensively to other anatomic sites or is no longer responding to treatment.


Childhood Benign Cerebral Neoplasm

description: A childhood neoplasm that arises from the cerebrum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


A member of the class of 2-pyranones that is 2H-pyran-2-one which has been substituted at positions 4 and 6 by hydroxy and pyridin-3-yl groups, respectively.


Retropharyngeal Neoplasm

description: A benign or malignant neoplasm that affects the retropharyngeal space.


Malignant Retropharyngeal Neoplasm

description: A primary or metastatic malignant neoplasm that affects the retropharyngeal space.


Benign Retropharyngeal Neoplasm

description: A neoplasm that arises from the retropharyngeal space and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Group B Streptococcal Infection, Late-Onset

description: Infection of an infant from seven days to three months of life caused by Group B Streptococcus (Streptococcus agalactiae).


name: Group B Streptococcal Infection, Early-Onset

description: Infection of an infant from birth to less than seven days of life caused by Group B Streptococcus (Streptococcus agalactiae) from a colonized mother.


A trans,trans-2,3,4,5-tetradehydroacyl-CoA having trans,trans-octa-2,4-dienoyl as the S-acyl component.


A trans,trans-2,3,4,5-tetradehydroacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of trans,trans-2,4-hexadienoic acid.


A trans,trans-2,3,4,5-tetradehydroacyl-CoA having trans,trans-deca-2,4-dienoyl as the S-acyl component.


A medium-chain primary fatty alcohol that is dodecane carrying hydroxy groups at positions 1 and 2.


dodecanediol

A diol that is dodecane carrying two hydroxy groups at unspecified positions.


A medium-chain primary fatty alcohol that is dodecane carrying hydroxy groups at positions 1 and 8.


A medium-chain primary fatty alcohol that is dodecane carrying hydroxy groups at positions 1 and 9.


A medium-chain primary fatty alcohol that is dodecane carrying hydroxy groups at positions 1 and 5.


A medium-chain primary fatty alcohol that is dodecane carrying hydroxy groups at positions 1 and 6.


A medium-chain primary fatty alcohol that is dodecane carrying hydroxy groups at positions 1 and 3.


A medium-chain primary fatty alcohol that is dodecane carrying hydroxy groups at positions 1 and 10.


A medium-chain primary fatty alcohol that is dodecane carrying hydroxy groups at positions 1 and 7.


A medium-chain primary fatty alcohol that is dodecane carrying hydroxy groups at positions 1 and 12.


A medium-chain primary fatty alcohol that is dodecane carrying hydroxy groups at positions 1 and 4.


name: Stage IVC Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Umbilical hernia with gangrene

description: A protrusion of necrotic tissue through the abdominal wall under the skin near the umbilicus.


Cerebral abscess

description: A bacterial, fungal, or parasitic abscess that develops in the cerebral hemispheres. Causes include skull trauma, middle ear infection, congenital heart disease, and frontal and ethmoid sinus infection.


Epithelioid schwannoma

description: A schwannoma characterized by the presence of epithelioid cells with eosinophilic cytoplasm, within a myxoid and/or hyalinized stroma.


digoxigenin monodigitoxoside

A steroid saponin that consists of digoxigenin having a digitoxosyl residue attached at position 3.


gitoxin

A cardenolide glycoside that is gitoxigenin in which the 3beta-hydroxy group has been glycosylated with tridigitoxose.


A cardenolide glycoside that is the 16-acetate of gitoxin.


ELAEODENDROSIDE V

A cardenolide glycoside that is sarmentologenin glycosylated at position 3 by a beta-allosyl-(1->4)-beta-6-deoxyallosyl moiety. Isolated from Elaeodendron alluaudianum, it exhibits antiproliferative activity against human ovarian cancer and human histiocytic lymphoma cell lines.


A cardenolide glycoside that is the 7,8-dehydroderivative of cerberin. Isolated from Cerbera manghas, it exhibits cytotoxic activity.


tanghinin

A  cardenolide glycoside that is  tanghinigenin attached to a 2-O-acetyl-6-deoxy-3-O-methyl-alpha-L-glucopyranosyl residue at position 3 via a glycosidc linkage. Isolated from Cerbera manghas, it exhibits cytotoxic activities against oral human epidermoid carcinoma (KB), human breast cancer cell (BC) and human small cells lung cancer.


cardenolide glycoside

Any member of the class of cardenolides with glycosyl residues attached to position 3.


acovenoside A

A cardenolide glycoside that is the 3-(6-deoxy-3-O-methyl-alpha-L-taloside) of 1beta,3beta,14-trihydroxy-5beta-card-20(22)-enolide.


GITALOXIN

A cardenolide glycoside that is gitoxin in which the 16beta-hydroxy group has been formylated.


evomonoside

A cardenolide glycoside consisting of digitoxigenin having an alpha-L-rhamnosyl moiety attached at the O(3)-position.


dihydroouabain

A cardenolide glycoside that is ouabain in which the double bond in the lactone ring has been reduced to a single bond. It is a cardiac glycoside and a derivative of ouabain which is used as a sodium pump antagonist and exhibits ionotropic effects.


oleandrigenin monodigitoxoside

A steroid saponin that consists of oleandrigenin having a digitoxosyl residue attached at position 3.


cerberin

A cardenolide glycoside that is the 2'-acetyl derivative of neriifolin.


tanghinigenin

A member of the class of  cardenolides that is 7,8-epoxycard-20(22)-enolide substituted by hydroxy groups at positions 3 and 14 (the 3beta,5beta,7beta stereoisomer).


deacetyltanghinin

A  cardenolide glycoside that is the deacetyl derivative of tanghinin. Isolated from Cerbera manghas, it exhibits cytotoxic activities against oral human epidermoid carcinoma (KB), human breast cancer cell (BC) and human small cells lung cancer.


A cardenolide glycoside that is the 12-acetate of digoxin.


NERIIFOLIN

A cardenolide glycoside that is digitoxigenin in which the hydroxy goup at position 3 has been converted to its (6-deoxy-3-O-methyl-alpha-L-glucopyranoside derivative. Found in the seeds of Cerbera odollamand in Thevetia ahouia and Thevitia neriifolia.


A cardenolide glycoside consisting of digitoxigenin having a beta-D-glucopyrananosyl-(1->4)-alpha-L-acofriopyranosyl moiety attached at the 3-position.


strospeside

A cardenolide glycoside in which the parent structure gitoxigenin is glycosylated at the 3beta-hydroxy group by beta-D-digitalose.


ELAEODENDROSIDE U

A cardenolide glycoside that is carda-4,20(22)-dienolide substituted by hydroxy groups at positions 2 and 14, an oxo group at position 12 and a (4-deoxy-3-O-methyl-alpha-L-erythro-pentopyranosyl)oxy moiety at position 3 (the 2alpha,3beta stereoisomer). Isolated from from wood of Elaeodendron tangenala, it exhibits antiproliferative activity against A2780 human ovarian cancer cells.


SARMENTOGENIN

A member of the class of cardenolides that is 5beta-card-20(22)-enolide which is substituted by hydroxy groups at the 3beta, 11alpha, and 14beta positions.


(S)-proglumide

The (S)-enantiomer of the racemic drug proglumide.


palmityl palmitoleate

A wax ester obtained by the formal condensation of  hexadecan-1-ol with  palmitoleic acid.


A 3beta-hydroxy steroid that is ecdysone in which the hydroxy group at position 25 is replaced by a hydrogen.


tyclopyrazoflor

A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 4 by a pyridin-3-yl group, chloro group and an ethyl{3-[(3,3,3-trifluoropropyl)sulfanyl]propanoyl}nitrilo group, respectively. It is an insecticide from Dow AgroSciences LLC.


name: Adult Diffuse Midline Glioma, H3 K27-Altered

description: A rare diffuse midline glioma, H3 K27-altered that occurs during adulthood.


name: Metastatic Adult Malignant Neoplasm in the Brain

description: A malignant neoplasm that has spread from its original site of growth to the brain in an adult patient.


Adult Brain Glioblastoma

description: A brain glioblastoma that occurs during adulthood.


Recurrent WHO Grade 4 Glioma

description: The reemergence of WHO grade 4 glioma after a period of remission.


name: Recurrent Diffuse Midline Glioma, H3 K27M-Mutant

description: The reemergence of diffuse midline glioma, H3 K27M mutant, after a period of remission.


An amino tetrasaccharide consisting of a 6-O-[(2-aminoethoxy)(hydroxy)phosphoryl-alpha-D-mannopyranosyl residue, two alpha-D-mannopyranosyl residues, and a 2-amino-alpha-D-glucose residue linked together in sequence by (1->2), (1->6) and (1->4) glycosidic bonds.


name: Congenital anomaly of the urinary tract proper

description: An abnormality of the kidney, ureter, bladder, or urethra that is present at birth. Representative examples include renal hypoplasia, renal agenesis, accessory kidney, absence of ureter, atresia of bladder neck, and atresia of urethra.


Urachal remnant

description: Remaining collapsed and obliterated urachal tissue between the bladder dome and umbilicus.


Posterior Urethral Valves Type 1

description: A posterior urethral valve extending from the vera montanum towards the distal meatus.


Posterior Urethral Valves Type 3

description: A posterior urethral valve, presumed to result from incomplete canalization of the urethra, that is located immediately distal to the vera montanum.


Double kidney (disorder)

description: A congenital abnormality of the kidney characterized by the presence of two separate pelvicocaliceal systems with a single or duplex ureter.


Congenital Renal Hypoplasia

description: The underdevelopment of otherwise normal renal parenchyma, characterized by decreased nephron size and possibly a decreased number of nephrons at birth.


Prostatic Duct Urothelial Carcinoma

description: An urothelial carcinoma that arises from the urothelial lining of the prostatic ducts.


name: Ann Arbor Stage II Supradiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


name: large cell neuroendocrine carcinoma of kidney

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the kidney.  It is characterized by the presence of malignant large cells.


name: 4,5-dichloro-3-isothiazolecarboxylic acid [1-oxo-1-(thiophen-2-ylmethylamino)butan-2-yl] ester


An N,N-disubstituted toluene-p-sulfonamaide, with a structure close to that of darunavir. It is found to inhibit dimerization of HIV-1 protease subunits.


A cholestanoid that is cholestanol which is substituted by a hydroxy group at position 26 and has R-configuration at position 25.


name: Squamous cell carcinoma of the oral cavity stage I

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage I Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage I includes: T1, N0, M0. T1: Tumor 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


The 5alpha-stereoisomer of  4,5-dihydrocortisone.


N-acylserotonin

A fatty amide resulting from the condensation of the carboxy group of a fatty acid with the primary amino group of serotonin.


(2R)-hydroperoxy fatty acid

Any 2-hydroperoxy fatty acid which has R configuration at the carbon bearing the hydroperoxy group.


(R)-2-hydroperoxy-alpha-linolenic acid

A hydroperoxy fatty acid that is alpha-linolenic acid having a single hydroperoxy substituent located at the 2R-position.


Childhood Bone Osteosarcoma

description: An osteosarcoma that arises from the bone and occurs during childhood.


Refractory Childhood Osteosarcoma

description: Childhood osteosarcoma that is resistant to treatment.


(R)-thalidomide

A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has R-configuration at the chiral centre.


name: Benign Extrahepatic Bile Duct Non-Epithelial Neoplasm

description: A neoplasm that arises from the non-epithelial tissues of the extrahepatic bile ducts and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Extrahepatic Bile Duct Fibroma

description: A benign neoplasm arising from the extra hepatic bile duct. It is characterized by the presence of spindle-shaped fibroblasts.


name: Benign Extrahepatic Bile Duct Soft Tissue Neoplasm

description: A mesenchymal neoplasm that arises from the extrahepatic bile ducts and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Extrahepatic Bile Duct Benign Granular Cell Tumor

description: A granular cell tumor that arises from the extrahepatic bile ducts and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Pigmented epithelioid melanocytoma

description: A rare cutaneous melanocytic neoplasm that presents as a slow growing pigmented nodule or papule. It is characterized by the proliferation of heavily pigmented epithelioid and dendritic cells, predominantly in the dermis. PRKAR1A gene inactivation is present in the majority of cases. It can spread to regional lymph nodes, but distant metastases are rare.


name: Grade 3 or 4 Elevation of AST, ALT, and/or Bilirubin

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A finding of grade 3 or 4 AST, Grade 3 or 4 ALT, and/or grade 3 or 4 bilirubin.


Unresectable Pilocytic Astrocytoma

description: A pilocytic astrocytoma that is not amenable to surgical resection.


Unresectable Astrocytic Tumor

description: An astrocytic tumor that is not amenable to surgical resection.


Unresectable Glioblastoma

description: A glioblastoma that is not amenable to surgical resection.


Unresectable Astrocytoma, IDH-Mutant

description: Astrocytoma, IDH-mutant that is not amenable to surgical resection.


hydroxyindoles

Any member of the class of  indoles carrying at least one hydroxy group.


dihydroxyindole

Any member of the class of  hydroxyindoles carrying two hydroxy groups.


deoxyviolaceinic acid

A pyrrolecarboxylic acid that is pyrrole-2-carboxylic acid which is substituted at position 3 by a 3-hydroxyindol-3-yl group at at position 5 by an indol-3-yl group.


violaceinic acid

A pyrrolecarboxylic acid that is pyrrole-2-carboxylic acid which is substituted at position 3 by a 3-hydroxyindol-3-yl group at at position 5 by a 5-hydroxyindol-3-yl group.


proviolacein

A hydroxyindole that is 2H-pyrrol-2-one which is substituted at positions 3 and 5 by 1H-indol-3-yl and 5-hydroxy-1H-indol-3-yl groups, respectively. It is an intermediate in the biosynthesis of the purple chromobacterial pigment violacein from L-tryptophan.


protoviolaceinic acid

A pyrrolecarboxylic acid that is pyrrole-2-carboxylic acid which is substituted at position 3 by a 1H-indol-3-yl group at at position 5 by a 5-hydroxy-1H-indol-3-yl group.


name: follicular dendritic cell sarcoma of thyroid gland

description: A rare follicular dendritic cell sarcoma involving the thyroid gland. It may be associated with chronic lymphocytic thyroiditis.


Moderate Bronchopulmonary Dysplasia

description: A chronic lung disorder associated with pulmonary maldevelopment, scarring, and/or inflammation that develops in preterm neonates exposed to supplemental oxygen for at least 28 days. For infants born before 32 weeks gestation with moderate BPD, there is a supplemental oxygen requirement of less than 30% at 36 weeks postmenstrual age or earlier discharge. For infants born after 32 weeks with moderate BPD, there is a supplemental oxygen requirement of less than 30% at 56 days post-natal age or at earlier discharge.


Kidney Lymphangioma

description: A rare lymphangioma arising from the kidney.


Prostate Hemangioma

description: A rare hemangioma that arises from the prostate gland.


Vulvar Congenital Melanocytic Nevus

description: A benign nevus that arises from the vulva and is present at birth.


Congenital small melanocytic nevus

description: A congenital melanocytic nevus of small size, with a diameter smaller than 15 mm. It presents as a macular, papular or plaque-like lesion.


name: Intermediate Congenital Melanocytic Nevus

description: A congenital melanocytic nevus measuring 15-200 mm. It is typically amenable to surgical resection.


name: Proliferative dermal lesion in congenital nevus

description: A benign proliferation of epithelioid or spindled melanocytes usually in the upper or mid dermis in a background of congenital melanocytic nevus. The congenital melanocytic nevus is usually of the deep type, involving the dermis and extending into the subcutaneous tissue. It presents as a dark plaque or nodule above a giant congenital melanocytic nevus.


An oxo-fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxylic acid group of 3-oxooctanoic acid.


name: Central Nervous System Solitary Fibrous Tumor, Grade 1

description: A solitary fibrous tumor that arises from the central nervous system. It corresponds most often to the collagenous and low cellularity spindle cell tumor which was diagnosed as central nervous system solitary fibrous tumor in the past.


6-carboxyrhodamine 6G

A rhodamine 6G compound having a carboxy substituent in the 6-position.


all-trans-retinyl oleate

A fatty acid ester formed between oleic acid and all-trans-retinol.


A steroid saponin isolated from Ornithogalum thyrsoides and has been shown to exhibit cytotoxic activity.


An omega-hydroxy fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 16-hydroxyhexadecanoic acid.


A beta-D-glucoside that is the 5-aminopentyl glycoside of a tetrasaccharide consisting of beta-D-glucosyl, beta-D-galactosyl, beta-D-glucuronosyl and beta-D-glucosyl residues linked sequentially (1->4).


name: Familial Hemophagocytic Lymphohistiocytosis Type 4

description: Familial hemophagocytic lymphohistiocytosis caused by biallelic mutations in the STX11 gene.


name: Familial Hemophagocytic Lymphohistiocytosis Type 2

description: Familial hemophagocytic lymphohistiocytosis caused by biallelic mutations in the PRF1 gene.


name: Familial Hemophagocytic Lymphohistiocytosis Type 3

description: Familial hemophagocytic lymphohistiocytosis caused by biallelic mutations in the UNC13D gene.


description: The reemergence of hemophagocytic lymphohistiocytosis after a period of remission.


description: Hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection.


name: Familial Hemophagocytic Lymphohistiocytosis Type 5

description: Familial hemophagocytic lymphohistiocytosis caused by biallelic mutations in the STXBP2 gene.


description: Hemophagocytic lymphohistiocytosis associated with a viral infection.


Refractory Fungal Infection

description: A fungal infection that is resistant to treatment.


Mild Bronchopulmonary Dysplasia

description: A chronic lung disorder associated with pulmonary maldevelopment, scarring, and/or inflammation that develops in preterm neonates exposed to supplemental oxygen for at least 28 days. For infants born before 32 weeks gestation with mild BPD, there is no supplemental oxygen requirement at 36 weeks postmenstrual age or earlier discharge. For infants born after 32 weeks with mild BPD, there is no supplemental oxygen requirement at 56 days post-natal age or at earlier discharge.


H influenze type B Pneumonia

description: Pneumonia that is attributed to the bacteria H influenze type B.


Collapsed Lung

description: Atelectasis of an entire lung.


Community acquired pneumonia

description: Pneumonia that is not acquired in a hospital or long-term care facility setting.


name: Somatoform autonomic dysfunction - respiratory tract

description: A respiratory malfunction for which mental factors play a causative role.


Acute pneumonia

description: Acute inflammation of the lung parenchyma caused by viruses, bacteria, fungi, radiation treatment, or exposure to chemicals.  Signs and symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness.


Non-Neoplastic Lung Disorder

description: A lung disorder not caused by a neoplasm. Representative examples include chronic obstructive pulmonary disease, atelectasis, lung infections, pulmonary fibrosis, and pneumoconiosis.


Bronchiolitis Obliterans Syndrome

description: Bronchiolitis obliterans following lung or allogeneic hematopoietic cell transplantation.


Follicular Bronchitis/Bronchiolitis

description: A non-neoplastic disorder characterized by the formation of reactive lymphoid follicles adjacent to distal bronchi and bronchioles.  It presents with mild shortness of breath and is associated with immunodeficiency syndromes and collagen vascular disorders.


COVID-19-Associated Pneumonia

description: Pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is characterized by the presence of ground glass opacities on CT scan images.


Congenital anomaly of lung

description: A malformation in the lung that is present at birth. Representative examples include pulmonary hypoplasia, pulmonary agenesis, congenital lobar emphysema, and alveolar capillary dysplasia.


Pulmonary alveolitis

description: Inflammation of the alveoli of the lung.


name: Respiratory Failure Related to Neuromuscular Disorder

description: Impaired gas exchange by the respiratory system resulting in hypoxemia and decreased oxygenation of the tissues that may be associated with increased arterial levels of carbon dioxide; the respiratory failure is due to a neuromuscular disorder.


Pulmonary cryptococcosis

description: Fungal pneumonia caused by inhalation of particles of Cryptococcus.  It usually occurs in immunocompromised patients such as persons with AIDS, transplant recipients, patients receiving cytotoxic chemotherapy, and patients with hematologic malignancies.  It is rare in immunocompetent individuals.  Signs and symptoms include fever, cough, and dyspnea.


name: Pneumonia caused by respiratory syncytial virus

description: Pneumonia that is attributed to the respiratory syncytial virus.


Hospital acquired pneumonia

description: Pneumonia acquired during a hospital stay.


Paracicatricial Emphysema

description: The development of dilated terminal airspaces in the lung adjacent to parenchymal scarring.


name: Chronic obstructive asthma (with obstructive pulmonary disease)

description: Chronic airway obstruction caused by asthma.


Pulmonary vascular disorder

description: A category of non-neoplastic disorders that affect the blood vessels in the lungs.  Representative examples include pulmonary embolism, pulmonary hypertension, and arteriovenous malformations.


Steroid-Refractory Pneumonitis

description: Pneumonitis that does not respond to corticosteroid therapy.


Tuberculous bronchiectasis

description: Bronchiectasis that develops in patients with a history of pulmonary tuberculosis.  It is usually associated with healed scars but occasionally may be seen in patients with active pulmonary tuberculosis.


Severe acute respiratory infection

description: A respiratory infectious disorder that leads to an acute illness that requires medical attention.


Stannosis

description: A disorder associated with chronic exposure to inhaled tin oxide dust or fumes.


Severe Bronchopulmonary Dysplasia

description: Bronchopulmonary dysplasia that results in severe respiratory complications. The infants with severe symptoms are usually premature, have low birth weight, and the oxygen and ventilation support requirements are increased.


name: Pneumonia caused by methicillin resistant Staphylococcus aureus

description: Pneumonia that is caused by Staphylococcus aureus that is resistant to methicillin treatment.


Cannabinosis

description: A disorder associated with chronic exposure to inhaled dust during the processing of hemp.


Asbestos-Related Lung Disorder

description: A disorder affecting the lungs due to asbestos exposure. Examples include asbestosis and lung carcinoma.


Toxoplasma Pneumonia

description: Pneumonia caused by the parasite Toxoplasma gondii.  It usually presents as an opportunistic infection in immunocompromised patients, especially patients with AIDS.  It is rare in immunocompetent individuals.  Signs and symptoms include cough, fever, and dyspnea.


Secondary Pneumonia

description: A pneumonia that occurs during or following treatment for an acute (primary) pneumonia that was caused by a different organism. It may be the result of increased susceptibility due to the initial treatment.


Pulmonary trunk hypoplasia

description: Underdeveloped pulmonary arteries.


Non-cardiogenic pulmonary edema

description: Pulmonary edema that is not a result of cardiac dysfunction.


name: Respiratory Failure Related to Central Nervous System Disorder

description: Impaired gas exchange by the respiratory system resulting in hypoxemia and decreased oxygenation of the tissues that may be associated with increased arterial levels of carbon dioxide; the respiratory failure is due to a central nervous system disorder.


name: Autoimmune Pulmonary Alveolar Proteinosis

description: A type of pulmonary alveolar proteinosis associated with low concentrations of GM-CSF.


Sickle Cell Chronic Lung Disease

description: A pulmonary complication of sickle cell disease characterized by radiographic interstitial abnormalities and impaired pulmonary function. In severe cases, pulmonary hypertension is present.


Atypical pneumonia

description: Historical term that references a form of pneumonia caused by Mycoplasma pneumoniae, Chlamydophila pneumoniae, or Legionella species.


Hyaline Membrane Syndrome

description: A serious disorder affecting newborns, particularly premature infants. It is caused by deficiency of surfactant, resulting in the formation of a membrane in the alveoli lining. This membrane contains fibrin and cellular debris and interferes with respiration. Infants with this disorder develop breathing problems immediately or in a few hours after delivery. It may lead to respiratory failure.


Fibrotic Hypersensitivity Pneumonitis

description: Interstitial lung fibrosis resulting from chronic hypersensitivity pneumonitis.


AIDS-Related Pneumocystis Pneumonia

description: A serious AIDS-related opportunistic infection of the lungs, caused by Pneumocystis jirovecii.  It is one of the most common AIDS-related illnesses and is a major cause of morbidity in patients with AIDS.  Signs and symptoms include cough, fever, dyspnea, and pain or tightness in the chest.


Pulmonary Precancerous Condition

description: A premalignant pathologic process that affects the lungs.  This category includes bronchial intraepithelial neoplasia and atypical adenomatous hyperplasia.


Acute pulmonary edema

description: Rapid or severe onset or rapid progression of pulmonary edema causing significant hypoxemia or the need for supplemental oxygen.


Diffuse Panbronchiolitis

description: A clinico-pathologic syndrome primarily affecting the respiratory bronchioles with evidence of inflammation in all layers of the bronchiole. Sinusitis is often an accompanying feature.


A piperidinecarboxylate ester that is the methyl ester of 3-hydroxypiperidine-1-carboxylic acid.


name: 2-[(2R,3S,6S)-3-amino-2-(hydroxymethyl)-3,6-dihydro-2H-pyran-6-yl]acetic acid methyl ester


Mesothelial hyperplasia

description: A hyperplasia of the mesothelial cells.


Atypical Mesothelial Hyperplasia

description: An atypical hyperplasia of the mesothelial cells.


Infectious Salpingitis

description: An acute or chronic infectious process affecting the fallopian tube. Chlamydia trachomatis, Neisseria gonorrhea, Mycoplasma, Staphylococcus, and Streptococcus are the most common causative agents.


A beta-D-Glcp-(1->6)-D-Galp in which the carbon bearing the anomeric hydroxy group has beta configuration.


A glycosylgalactose consisting of a beta-D-glucopyranose residue and a D-galactopyranose residue joined in sequence by a (1->6) glycosidc bond.


A beta-D-Glcp-(1->6)-D-Galp in which the carbon bearing the anomeric hydroxy group has alpha configuration.


Conjunctival Rhabdomyosarcoma

description: A rhabdomyosarcoma that arises from the conjunctiva.


A 15-HETrE consisting of (8Z,11Z,13E)-icosatrienoic acid in which the 15-hydroxy group has S-configuration.


7-demethylmitomycin B

A member of the family of mitomycins that is mitomycin B in which the methoxy group  on the quinone ring is replaced by a hydroxy group.


MITOMYCIN A

A member of the family of mitomycins that exhibits antibiotic and antitumour properties as well as a high level of toxicity.


mitomycin

A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.


7-demethylmitomycin A

A member of the family of mitomycins that is mitomycin A in which the methoxy group on the quinone ring is replaced by a hydroxy group.


MITOMYCIN B

A member of the family of mitomycins that exhibits antibiotic and antitumour properties.


(S)-pydiflumetofen

3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-(2,4,6-trichlorophenyl)propan-2-yl]pyrazole-4-carboxamide that is the (S)-enantiomer of pydiflumetofen.


A 2,3-diacyl-1-alpha-D-galactosyl-sn-glycerol in which the groups at the 1- and 2-positions are palmitoyl and oleoyl respectively.


onium betaine

Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


acetonitrile oxide

The nitrile oxide resulting from the oxidation of the nitrogen atom of acetonitrile.


saturated fatty acyl-L-carnitine

An O-acylcarnitine in which the R is a saturated fatty acyl chain.


O-valeroylcarnitine

A C5-acylcarnitine in which the acyl group specified is valeroyl.


CEFTAROLINE

A cephalosporin that is the active metabolite of the prodrug ceftaroline fosamil.  Used for the treatment of adults with acute bacterial skin and skin structure infections.


6-(methylthio)hexanonitrile oxide

A nitrile oxide that is pentane in which two of the terminal methyl hydrogens at positions 1 and 5 have been replaced by oxidonitrile and methylsulfanyl groups.


nitrilium betaine

Derivatives of nitriles having the general structure R-C#N(+)-Y(-). A subclass of 1,3-dipolar compounds including nitrile imides, nitrile oxides, nitrile sulfides and nitrile ylides.


cis-4-hydroxy-D-proline betaine

An amino-acid betaine that is trans-4-hydroxy-D-proline zwitterion in which both of the hydrogens attached to the nitrogen have been replaced by methyl groups.


O-lauroyl-L-carnitine

An O-acyl-L-carnitine in which the acyl group is specified as lauroyl (dodecanoyl).


O-acylcarnitine

Any carboxylic ester obtained by the O-acylation of carnitine.


thiaminium carboxylate betaine

An ammonium betaine that is the conjugate base of thiamine(1+) carboxylic acid arising from the deprotonation of the carboxy group.


amino-acid betaine

Any amino acid-derived zwitterion - such as glycine betaine (N,N,N-trimethylammonioacetate) - in which the ammonium nitrogen carries methyl substituents and bears no hydrogen atoms.


O-valeroyl-L-carnitine

An O-acyl-L-carnitine in which the acyl group specified is valeroyl.


fatty acyl-L-carnitine

Any O-acylcarnitine in which the carnitine component has L-configuration and the acyl group is a fatty acid.


O-hexanoylcarnitine

An O-acylcarnitine compound having hexanoyl as the acyl substituent.


O-octanoyl-D-carnitine

An O-acyl-D-carnitine in which the acyl group specified as octanoyl.


trans-4-hydroxy-L-proline betaine

An amino-acid betaine that is trans-4-hydroxy-L-proline zwitterion in which both of the hydrogens attached to the nitrogen have been replaced by methyl groups.


fenmezoditiaz

An iminium betaine that is 2,3,7,8-tetrahydro[1,3]thiazolo[3,2-a]pyrimidin-4-ium substituted by a 2-chloro-1,3-thiazol-5-yl, oxidanidyl, phenyl, oxo, and methyl groups at positions 3R, 5, 6, 7 and 8, respectively. It is a mesoionic insecticide developed by BASF.


O-dodecanoylcarnitine

An O-acylcarnitine having dodecanoyl as the acyl substituent.


O-decanoylcarnitine

An O-acylcarnitine compound having decanoyl as the acyl substituent.


O-decanoyl-L-carnitine

An O-acyl-L-carnitine that is L-carnitine having decanoyl as the acyl substituent.


O-isovalerylcarnitine

A C5-acylcarnitine having isovaleryl as the acyl substituent.


thiamine(1+) triphosphate(1-)

An ammonium betaine that is the conjugate base of thiamine(1+) triphosphate arising from the deptoronation of one of the hydroxy groups of the terminal phosphate group.


CYNOOXIDE ANION

A nitrile oxide resulting from the oxidation of hydrogen cyanide.


An optically active form of O-2-methylbutyrylcarnitine having (R)-configuration.


D-CARNITINE

The (S)-enantiomer of carnitine.


O-hexanoyl-L-carnitine

An O-hexanoylcarnitine that has L configuration.


(S)-carnitinyl-CoA betaine

A 3-hydroxyacyl-CoA where the S-acyl group is specified as (S)-carnitinyl.


thiamine(1+) monophosphate(1-)

An ammonium betaine that is the conjugate base of thiamine(1+) monophosphate arising from the deprotonation of one of the phosphate hydroxy groups.


O-acyl-L-carnitine

An O-acylcarnitine in which the carnitine component has L-configuration.


O-octanoylcarnitine

An O-acylcarnitine having octanoyl as the acyl substituent.


sulfonium betaine

Neutral molecules having charge-separated forms with an sulfonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


O-butanoyl-L-carnitine

An optically active form of O-butanoylcarnitine having L-configuration.


Propionyl-Carnitine

An O-acylcarnitine compound having propanoyl as the acyl substituent.


O-pivaloylcarnitine

A C5-acylcarnitine in which the acyl group specified is pivaloyl.


7-(methylthio)heptanonitrile oxide

A nitrile oxide that is hexane in which two of the terminal methyl hydrogens at positions 1 and 6 have been replaced by oxidonitrile and methylsulfanyl groups.


O-tetradecanoyl-L-carnitine

An O-acyl-L-carnitine in which the acyl group is specified as myristoyl (tetradecanoyl).


ammonium betaine

Any neutral molecule having charge-separated forms with a quaternary ammonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


O-tetradecanoylcarnitine

An O-acylcarnitine having tetradecanoyl (myristoyl) as the acyl substituent.


Butyryl-carnitine

A C4-acylcarnitine  that is the O-butanoyl derivative of carnitine.


isovaleryl-L-carnitine

An O-isovalerylcarnitine that is the 3-methylbutanoyl (isovaleryl) derivative of L-carnitine.


O-octanoyl-L-carnitine

The L-enantiomer of an O-octanoylcarnitine.


A long-chain fatty alcohol that is tetradecan-1-ol bearing a methyl substituent at position 13.


name: Stage IA Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: pT1, N0, M0, S0. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Immature Teratoma

description: An immature teratoma occurring in children.


name: Localized Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Tumor confined to the testes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Choriocarcinoma

description: A choriocarcinoma occurring in children.


name: Stage III Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, Any N, M1, SX. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Testicular Yolk Sac Tumor, Prepubertal-Type

description: Testicular yolk sac tumor that almost always occurs in pure form and is not associated with germ cell neoplasia in situ. It affects young children and is the most frequently seen testicular neoplasm in prepubertal children.


Childhood Mature Teratoma

description: A mature teratoma occurring in children.


name: Refractory Childhood Malignant Germ Cell Tumor

description: A malignant germ cell tumor that occurs during childhood and is resistant to treatment.


name: Stage IIIC Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N1-N3, M0, S3 or Any pT, Any N, M1, S3. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage IIIB Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N1-N3, M0, S2 or Any pT, Any N, M1, S2. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Childhood Malignant Testicular Germ Cell Tumor

description: A malignant germ cell tumor in children arising from the testis.  It includes the embryonal carcinoma, yolk sac tumor, choriocarcinoma, and mixed germ cell tumors.


name: Recurrent Childhood Malignant Germ Cell Tumor

description: The reemergence of a malignant germ cell tumor in children after a period of remission.


name: Stage IB Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: pT2-4, N0, M0, S0. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Germinomatous Germ Cell Tumor

description: A germinomatous germ cell tumor occurring in children.


Childhood Mixed Germ Cell Tumor

description: A mixed germ cell tumor occurring in children.


name: Stage IIA Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N1, M0, S0, S1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage II Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N1-3, M0, SX. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Extracranial Germ Cell Tumor

description: A childhood benign or malignant germ cell tumor arising from an anatomic site other than the brain.


name: Metastatic Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Teratoma

description: A mature or immature teratoma occurring in children.


Childhood Seminoma

description: A seminoma occurring in children.


Childhood Embryonal Carcinoma

description: An embryonal carcinoma occurring in children.


Childhood Extragonadal Teratoma

description: An extragonadal teratoma that occurs during childhood.


name: Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood testicular germ cell tumor according to the tier 2 Toronto childhood cancer staging guidelines v2.


name: Regional Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Tumor extension to regional lymph nodes: interaortocaval, para-aortic (periaortic), paracaval, preaortic, precaval, retroaortic, retrocaval, and along spermatic cord. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage IIB Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N2, M0, S0, S1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Childhood Extragonadal Malignant Germ Cell Tumor

description: A malignant germ cell tumor in children arising from an anatomic site other than the testis or ovary.


name: Childhood Central Nervous System Teratoma

description: A mature or immature teratoma affecting the central nervous system and occurring in children.


Childhood Benign Germ Cell Tumor

description: A germ cell tumor that occurs during childhood and is characterized by the absence of atypia and metastatic potential.


name: Childhood Nongerminomatous Germ Cell Tumor

description: A nongerminomatous germ cell tumor occurring in children.


name: Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood testicular germ cell tumor according to the tier 1 Toronto childhood cancer staging guidelines v2.


name: Childhood Testicular Non-Seminomatous Germ Cell Tumor

description: A non-seminomatous germ cell tumor that arises in the testis and occurs in children.


name: Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood testicular germ cell tumor according to the Toronto childhood cancer staging guidelines v2.


name: Stage IS Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N0, M0, S1-3. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)