Recurrent Malignant Bone Neoplasm

description: Reemergence of a malignant bone neoplasm after a period of remission.


name: Gallbladder Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A mucinous cystic neoplasm that arises from the gallbladder and it is associated with an invasive carcinomatous component.


name: Sporadic Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is not caused by inherited genetic mutations.


Carcinoid tumor of the liver

description: An extremely rare, well differentiated neuroendocrine neoplasm arising from the liver. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation.


Voice Alteration

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Change in the sound and/or speed of the voice. Causes include laryngeal polyp, laryngitis, laryngeal carcinoma, throat carcinoma, Parkinson's disease, multiple sclerosis, stroke, hypothyroidism, oral surgery, tracheostomy, tracheal injury, and laryngeal injury.


Anoxia

description: Absence or reduction of oxygen in body tissue.


Adult Gliosarcoma

description: A gliosarcoma occurring in adults.


Stage II Ureter Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor invades the muscularis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Mosquito-borne hemorrhagic fever

description: A group of viral illnesses that are vectored by mosquitoes, and that are characterized by increased susceptibility to bleeding diatheses.


Hypomyelinating Leukodystrophy-22

description: An autosomal dominant condition caused by mutation(s) in the CLDN11 gene, encoding claudin-11.  It is characterized by global developmental delay, mild impaired intellectual development, limited ability to walk, and hypomyelinating leukodystrophy on MRI.


name: congenital renal arteriovenous malformation

description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the kidney.


Craniotubular Hyperostosis

description: A group of sclerosing bone dysplasias characterized by pronounced sclerosis of the cranial vault and the long bones, resulting in increased cortical bone density. Most cases are caused by mutation(s) in the SOST or LRP5 genes, encoding sclerostin and low-density lipoprotein receptor-related protein 5, respectively. Other genes have been implicated, and some cases have been described, but do not yet have identified genetic mutations.


name: Stage IB Gestational Trophoblastic Tumor AJCC v7

description: Stage IB includes: T1, M0, Risk factors: high risk.  T1: Tumor confined to uterus.  M0: No distant metastasis.  (AJCC 7th ed.)


Disseminated carcinoma

description: Carcinoma that is spread throughout the body.


Insomnia due to organic factors

description: Insomnia as a result of a physiological cause.


Congenital kyphosis

description: An abnormally increased curvature of the thoracic portion of the spine that is present at the time of birth.


name: Human Papillomavirus-Related Malignant Neoplasm in AIDS Patient

description: A malignant neoplasm caused by human papillomavirus in an a patient with a history of AIDS.


Metastatic Malignant Solid Neoplasm

description: A malignant solid neoplasm that has spread from its original site of growth to another anatomic site.


Tiring Pain

description: A sensation of discomfort or distress that renders an individual weary and without energy.


name: Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Alkylating Agent-Related Acute Myeloid Leukemia

description: Acute myeloid leukemia occurring as late complication of prior therapy with alkylating agents.


name: Invasive Bladder Large Nested Urothelial Carcinoma

description: A rare invasive bladder urothelial carcinoma characterized the presence of medium to large nests of malignant cells.


Fibromyxolipoma

description: A benign well-circumscribed tumor composed of mature adipocytes, characterized by areas of abundant fibrous tissue and extensive myxoid change.


Salt-Wasting 21-Hydroxylase Deficiency

description: A classic form of congenital adrenal hyperplasia characterized by complete absence of 21-hydroxylase activity resulting in deficiency of glucocorticoids and mineralocorticoids accompanied by androgen excess causing virilization in female infants. Mineralocorticoid deficiency results in renal salt-wasting, and if untreated, hyponatremia, hyperkalemia, and shock.


Appendix Mucinous Cystadenoma

description: A cystically dilated epithelial neoplasm arising from the appendix.  It is characterized by the presence of a cystic structure that is filled with mucus.


name: Hodgkin's disease, nodular sclerosis of lymph nodes of multiple sites

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Metastatic Bladder Small Cell Neuroendocrine Carcinoma

description: Bladder small cell neuroendocrine carcinoma that has spread to another anatomic site.


name: Prostate Cancer by Whitmore-Jewett Stage

description: A term that refers to the staging of prostate carcinoma according to the Whitmore-Jewett staging system.


name: Clinical Stage II Cutaneous Melanoma AJCC v8

description: Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA

description: Chronic eosinophilic leukemia characterized by the rearrangement of the PDGFRA gene, most often resulting in the formation of FIP1L1-PDGFRA fusion transcripts.


name: Childhood Acute Lymphoblastic Leukemia by Toronto Guidelines v2

description: A term that refers to the staging of childhood acute lymphoblastic Leukemia according to the Toronto childhood cancer staging guidelines v2.


Angiosarcoma recurrent

description: The reemergence of angiosarcoma after a period of remission.


Glioblastoma by Gene Expression Profile

description: Classification of glioblastoma into molecular subtypes as defined by gene expression profiling.


Metastatic Midgut Neuroendocrine Tumor

description: A midgut neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


Stage III Anal Cancer AJCC v8

description: Stage III includes: IIIA: (T1, N1, M0); (T2, N1, M0); IIIB: (T4, N0, M0); IIIC: (T3, N1, M0); (T4, N1, M0). T1: Tumor 2 cm or smaller. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. T3: Tumor larger than 5 cm. T4: Tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder. N0: No regional lymph node metastasis. N1: Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes. M0: No distant metastasis. (AJCC 8th ed.)


Primary acquired melanosis

description: A spectrum of neoplastic changes that occur in the conjunctiva and range from melanocytic hyperplasia through degrees of atypia to melanoma in situ. The lesions are generally unilateral but often multifocal and appear as flat, irregular brown discolorations of the conjunctiva. They usually affect middle-aged and elderly Caucasians. (WHO 2018)


Meningeal Gliomatosis

description: Diffuse or multifocal infiltration of the meninges by malignant glioma.


Gallbladder Goblet Cell Adenocarcinoma

description: An invasive mixed adenoneuroendocrine carcinoma of the gallbladder characterized by the presence of neoplastic signet-ring cells resembling goblet cells of the intestine.


name: High Grade Prostatic Intraepithelial Neoplasia, Small Cell Neuroendocrine Variant

description: High grade prostatic intraepithelial neoplasia characterized by the presence of small neuroendocrine cells in the affected glands.


name: Locally Advanced Ampulla of Vater Carcinoma

description: Carcinoma that arises from the ampulla of Vater and has spread to nearby tissues or lymph nodes.


name: Monomorphic Post-Transplant Lymphoproliferative Disorder

description: A clonal lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed lymphocytes or plasma cells.  It includes two variants: monomorphic B-cell and monomorphic T/NK cell post-transplant lymphoproliferative disorders.


Zoonotic Spillover

description: Transmission of an infectious disease from a reservoir vertebrate population with a high pathogen prevalence coming into contact with a naive human population.


name: Pathologic Stage IV Retinoblastoma AJCC v8

description: Stage IV includes: Any pT, Any N, cM1 or pM1, Any H. cM1: Distant metastasis without microscopic confirmation. pM1: Distant metastasis with microscopic confirmation. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


EBV-Associated Smooth Muscle Tumor

description: A rare smooth muscle neoplasm of uncertain biological potential. It is associated with Epstein-Barr virus infection and seen in patients with immunodeficiency, including primary immunodeficiency, HIV/AIDS infection, and post-transplant immunosuppression.


Cancer-Associated Pain

description: Pain associated with cancer or its diagnosis or treatment.


Locally Advanced Carcinoma

description: A carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Chest Pain Along Left Middle Sternal Border

description: The location of the chest pain is along the left middle border of the sternum.


Myocardial degeneration

description: Degeneration of myocardial tissue.


name: Postneoadjuvant Therapy Stage IVB Esophageal Adenocarcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Gastrinoma, malignant

description: A gastrin-producing neuroendocrine tumor.  It is characterized by inappropriate secretion of gastrin and associated with Zollinger Ellison syndrome.  It displays vascular invasion and metastasizes to other anatomic sites.


Megakaryocytic Neoplasm

description: A neoplasm affecting cells of the megakaryocytic lineage.


name: Chronic Cutaneous Graft Versus Host Disease

description: Chronic graft versus host disease (GvHD) occurring in the skin.


EBV positive mucocutaneous ulcer

description: A rare Epstein-Barr virus-positive B-cell lymphoproliferative disorder that affects mucosal sites (including oral mucosa, palate, tonsils, and gastrointestinal tract) and skin. It presents with well-circumscribed, often painful ulcers. It is associated with immune suppression, including age-related and drug-induced immunosuppression. In the majority of cases the lesions regress either spontaneously or following withdrawal of the immunosuppression therapy.


Malignant melanoma in junctional nevus

description: A melanoma arising from a melanocytic nevus which involves the dermal-epidermal junction of the skin.


name: Childhood Malignant Bone Neoplasm by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood malignant bone neoplasm according to the Toronto childhood cancer staging guidelines v2. Staging is the same for both tiers (tier 1 and 2).


description: A rare mucinous cystadenocarcinoma that arises from the paratesticular structures.


Recurrent Cancer of Gallbladder

description: The reemergence of gallbladder carcinoma after a period of remission.


Orbivirus infection

description: An infection that is caused by Orbivirus.


Unclassified Hepatocellular Adenoma

description: A hepatocellular adenoma without distinguished morphologic characteristics or known molecular abnormalities.


name: Congenital arteriovenous malformation of gastrointestinal tract

description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the gastrointestinal tract.


Contact dermatitis caused by acid

description: Contact dermatitis caused by exposure to acids.


Congenital His bundle tachycardia

description: A congenital disorder characterized by an electrocardiographic finding of tachycardia that affects neonates and infants. It results from an increased automaticity in the atrioventricular node and His bundle.


Childhood Ganglioneuroma

description: A ganglioneuroma that occurs during childhood.


Adenocarcinoma endometrial recurrent

description: The reemergence of endometrioid adenocarcinoma after a period of remission.


name: Myelodysplastic/Myeloproliferative Neoplasm Post Cytotoxic Therapy

description: A myelodysplastic/myeloproliferative neoplasm arising as a result of the mutagenic effect of chemotherapy agents and/or radiation that are used for the treatment of neoplastic or non-neoplastic disorders.


name: Adult Favorable Prognosis Hodgkin Lymphoma

description: A Hodgkin lymphoma with favorable prognosis that occurs during adulthood.


Unresectable Mucosal Melanoma

description: Mucosal melanoma that is not amenable to surgical resection.


Childhood Malignant Bone Neoplasm

description: A malignant neoplasm that affects the bone or articular cartilage and occurs during childhood.


name: Metastatic malignant neoplasm to soft tissues

description: A malignant neoplasm that has spread to the soft tissues from another anatomic site.


Toothache

description: A painful sensation originating from a tooth.


A2/3 Hydronephrosis

description: Antenatal hydronephrosis with the following clinical findings: 1) an anterior-posterior renal pelvis diameter (APRPD) of greater than or equal to 7mm at less than 28 weeks, 2) greater than or equal to10 mm at greater than or equal to 28 weeks, or 3) any one of the following findings: a)dilation of peripheral calyces, b) abnormal parenchymal thickness or appearance, c) visibly dilated ureter, d) an abnormal bladder, or e) the presence of oligohydramnios suspected to be related to the urinary tract. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


Carcinoma Unspecified Site

description: Carcinoma in which the site of involvement is not specified.


Locally Advanced Gallbladder Carcinoma

description: Gallbladder carcinoma that has spread to nearby tissues or lymph nodes.


Stage I Adult Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Nerve injury

description: Injury to nervous tissue.


Stage II Esophageal Cancer AJCC v7

description: Stage II includes: For squamous cell carcinoma: IIA (T2-3, N0, M0, G1, GX, Tumor location: Upper, middle); (T2-3, N0, M0, G2-3, Tumor location: Lower, X); IIB (T2-3, N0, M0, G2-3, Tumor location: Upper, middle); (T1-2, N1, M0, Any G, Tumor location: Any).  For adenocarcinoma: IIA (T2, N0, M0, G3); IIB (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Acute Myeloid Leukemia with STAT5B-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of STAT5B-RARA fusion protein.


Posterior Subcapsular Cataract Grade 2

description: A stage of posterior subcapsular cataract characterized by 30% of the posterior capsule obscured by opacity. (Modified LOCS II)


Mucosal ulcer

description: A circumscribed loss of integrity of the mucous membrane.


Recurrent T-Cell and NK-Cell Neoplasm

description: The reemergence of T-cell and NK-cell neoplasm after a period of remission.


Cannabis dependence, continuous

description: Physical and psychological dependence on the drug cannabis, which is associated with a pattern of continuous use.


Skin tumor of neural origin

description: A peripheral nervous system neoplasm that arises from the dermis.


Locally Advanced Gastric Adenocarcinoma

description: A gastric adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Anal Canal Neuroendocrine Tumor G1

description: A well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the anal canal. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


name: Bile Duct Biliary Intraepithelial Neoplasia

description: A neoplastic, non-invasive lesion that affects the intrahepatic or extrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


Locally Advanced Sarcoma

description: Sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Childhood EBV-Associated Smooth Muscle Tumor

description: An EBV-associated smooth muscle tumor that occurs during childhood.


Childhood Pilomatricoma

description: A pilomatricoma that occurs during childhood.


name: Locally Advanced Unresectable Bone Sarcoma

description: A bone sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Borderline Fallopian Tube Neoplasm

description: A rare epithelial tumor arising from the fallopian tube without definitive morphologic characteristics of malignancy.  This category includes borderline mucinous and serous neoplasms and borderline endometrioid tumor.


name: Recurrent Endometrial Serous Adenocarcinoma

description: The reemergence of endometrial serous adenocarcinoma after a period of remission.


name: Platinum-Refractory Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that progresses during platinum therapy or within one month of completing platinum therapy.


Stage IV Skin Cancer

description: Stage IV includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T Any, N3, M0); (T4, N Any, M0); (T Any, N Any, M1).  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  T3: Tumor with invasion of maxilla, mandible, orbit, or temporal bone.  T4: Tumor with invasion of skeleton or perineural invasion of skull base.  N0: No regional lymph node metastasis.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M1: Distant metastases.  (AJCC 7th Ed.)


Sebaceoma

description: A benign neoplasm characterized by sebaceous cell differentiation. It arises from the dermis and typically affects the face and neck.


Breast Papillary Neoplasm

description: A benign or malignant papillary neoplasm that arises from the breast.  It is characterized by the presence of epithelial proliferations that are supported by fibrovascular cores.  Representative examples are intraductal papilloma and papillary carcinoma.


name: Castleman Disease, Hyaline-Vascular Type

description: The commonest type of Castleman disease. It is seen most commonly in the mediastinum. Histologically this is characterized by hyalinized germinal centers surrounded by small lymphocytes in a concentric fashion, giving an onion skin appearance.


name: Invasive Bladder Giant Cell Urothelial Carcinoma

description: An invasive urothelial carcinoma of the bladder with giant cells.


Childhood Classic Hodgkin Lymphoma

description: Classic Hodgkin lymphoma that occurs during childhood.


name: Unresectable Digestive System Neuroendocrine Neoplasm

description: A digestive system neuroendocrine neoplasm that is not amenable to surgical resection.


Hidroacanthoma Simplex

description: A poroma characterized by the presence of aggregates of basaloid cells confined to the epidermis.


Recurrent Nevus

description: A nevus that recurs after incomplete surgical removal, biopsy, or trauma. (WHO 2018)


name: Locally Advanced Squamous Cell Carcinoma

description: A squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Major Congenital Anomaly

description: A major congenital anomaly is a structural or functional defect with the following three characteristics: 1) Of prenatal origin; 2) Present at the time of live birth or fetal demise, or in utero; 3) Affecting (or has the propensity to affect) the health, survival, or physical or cognitive functioning of the individual.


Carcinoma of unknown primary

description: A carcinoma which has metastasized from an unknown primary anatomic site.


name: Hematopoietic and Lymphoid Neoplasm (Antiquated)


name: Invasive Lymphoepithelioma-Like Urothelial Carcinoma

description: Invasive urothelial carcinoma with lymphoepithelioma-like features.


Clinical Chorioamnionitis

description: Inflammation of the fetal sac membranes, characterized by otherwise unexplained fever (at or above 38 degree C (100.4F)) with one or more of the following: uterine tenderness and/or irritability, leukocytosis, fetal tachycardia, maternal tachycardia, or malodorous vaginal discharge.


name: Ventral hernia without mention of obstruction or gangrene

description: The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the linea alba, without mention of obstruction or necrosis of the herniated contents.


Lumbar meningomyelocele

description: A congenital abnormality in the lumbar region of the spine, in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Autoimmune Atrophic Chronic Gastritis

description: Chronic atrophic gastritis that is caused by autoimmune destruction of parietal cells in the stomach resulting in hypochlorhydria and decreased production of intrinsic factor.


Stage I Low-CSD Melanoma AJCC v7

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Locally Advanced Bladder Adenocarcinoma

description: Bladder adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Malignant Bladder Paraganglioma

description: An extra-adrenal sympathetic paraganglioma of the bladder that metastasizes to other anatomic sites.


Infant Leukemia

description: An acute lymphoblastic or acute myeloid leukemia that occurs in infancy.


name: Ancylostomiasis due to Ancylostoma ceylonicum (disorder)

description: Infection by Ancylostoma ceylanicum.


Distal Esophagus Adenocarcinoma

description: An adenocarcinoma arising from the lower third of the esophagus. The vast majority of esophageal adenocarcinomas involve the lower third of the esophagus.


name: Cervical intraepithelial neoplasia grade 1

description: Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of mild dysplastic changes.


Diffuse KATP-Associated Hyperinsulinism

description: KATP-associated hyperinsulinism affecting all pancreatic beta cells.


Recurrent Acute Erythroid Leukemia

description: The reemergence of acute erythroid leukemia after a period of remission.


name: Anxiety disorder due to a general medical condition

description: An anxiety disorder in which the symptoms of anxiety have been determined to be the direct physiological consequence of a general medical condition.


Stage IVB Cervical Cancer FIGO 2009

description: Cervical carcinoma involving distal organs outside the pelvis. (FIGO 2009)


Basal cell carcinoma - keratotic

description: A variant of basal cell carcinoma with the architectural features of a nodular basal cell carcinoma.  It is characterized by the formation of keratin (horn cysts) in the center of the tumor islands.  Dystrophic calcification is frequently present.


Complication

description: Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure.


Anaplastic Diencephalic Astrocytoma

description: An anaplastic astrocytoma that occurs in the diencephalon.


Sclerosing Blue Nevus

description: A dendritic blue nevus characterized by the presence of prominent sclerotic stromal collagen.


description: A reactive proliferation of the conjunctival squamous epithelium not associated with glandular elements.


Recurrent Lymphoid Leukemia

description: The reemergence of lymphoid leukemia after a period of remission.


name: Lymphoproliferative Disease Associated with Primary Immune Disorder

description: A lymphoid proliferation that arises in the setting of immune deficiency due to a primary immunodeficiency or immunoregulatory disorder. The primary immune disorders most frequently associated with lymphoproliferative disorders are ataxia-telangiectasia, Wiskott-Aldrich syndrome, common variable immunodeficiency, severe combined immunodeficiency, X-linked lymphoproliferative disease, Nijmegen breakage syndrome, hyper-IgM syndrome, and autoimmune lymphoproliferative syndrome. (WHO 2017)


name: Radiating Chest Pain Along Right Lower Sternal Border

description: The location of the radiating chest pain is along the right lower sternal border.


name: Recurrent Histiocytic and Dendritic Cell Neoplasm

description: The reemergence of a histiocytic and dendritic cell neoplasm after a period of remission.


Stage III Childhood Hodgkin Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Vascular anomaly of eyelid

description: Any non-neoplastic or neoplastic disorder affecting the arteries, veins, or lymphatic vessels of the eyelid.


name: Stage III Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, Any N, M0). T1: Pheochromocytoma measuring less than 5 cm in greatest dimension, with no extra-adrenal invasion. T2: Pheochromocytoma measuring 5 cm or more in greatest dimension or paraganglioma-sympathetic of any size, with no extra-adrenal invasion. T3: Tumor of any size with invasion into surrounding tissues (e.g., liver, pancreas, spleen, kidneys). N1: Regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Stage IIIA Esophageal Adenocarcinoma AJCC v7

description: Stage IIIA includes: (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


verrucous carcinoma of vagina

description: A squamous cell carcinoma that arises from the vagina and is characterized by a papillary growth pattern, acanthotic epithelium with minimal or absent atypia, and pushing borders.


name: Testicular Seminoma with Syncytiotrophoblastic Cells

description: A testicular seminoma characterized by the presence of syncytiotrophoblastic giant cells.


Peritoneal Implant

description: Deposits of borderline, malignant, and rarely benign tumors, usually from the ovary, on the peritoneal surface.


Resectable Cutaneous Melanoma

description: Cutaneous melanoma that is amenable to surgical resection.


name: Adult Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

description: An acute myeloid leukemia with recurrent genetic abnormalities occurring in adults.


High Grade Liver Dysplastic Nodule

description: A hepatic dysplastic nodule characterized by the presence of high grade atypical cellular changes.


Sporadic Gastric Adenocarcinoma

description: A primary adenocarcinoma of the stomach in a patient with no family history of gastric cancer or inherited high risk mutations.


Subacute Placental Infarction

description: A focus of necrotic placental parenchyma with moderate hyalinization and fibrosis with partial absence of the necrotic chorionic villi, which is frequently 3-5 days of duration.


K ATP Permanent Neonatal Diabetes

description: K ATP channel-associated neonatal diabetes mellitus that does not resolve spontaneously.


Resectable Sarcoma

description: Sarcoma that is amenable to surgical resection.


description: Thrombotic microangiopathy of the gastrointestinal tract.


name: Clinical Stage I Cutaneous Melanoma AJCC v8

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Advanced Adnexal Carcinoma

description: Adnexal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Endometrial cystic hyperplasia

description: Benign endometrial hyperplasia characterized by the presence of cystically dilated glands.


Childhood Skin Neoplasm

description: A benign, intermediate, or malignant neoplasm that affects the skin and occurs during childhood.


Imaging Finding

description: The result of an evaluation technique using a visual display of structural or functional patterns of organs or tissues that is performed to determine the presence, absence, or degree of a condition.


Papillary mucinous cystadenoma

description: A usually benign and less often low malignant potential cystic epithelial neoplasm composed of cells which contain intracytoplasmic mucin. It is characterized by the presence of papillary structures.


name: Acute gonococcal infection of lower genitourinary tract

description: A gonococcal infection of the lower urinary tract that is rapid in onset.


name: Musculoskeletal Chest Pain due to Rib Injury

description: A condition in which there is musculoskeletal chest pain secondary to trauma to one or more ribs. (ACC/AHA)


Parathyroid Clear Cell Hyperplasia

description: A hyperplasia of the clear cells of the parathyroid gland.


Paradental Cyst

description: An inflammatory collateral cyst that arises on the lower third molars. (WHO 2017)


Malignant Paraganglionic Neoplasm

description: A paraganglioma that metastasizes to regional or distant anatomic sites.  Extraadrenal paragangliomas have a higher tendency to metastasize, as compared to pheochromocytomas.  Common sites of metastasis include the lymph nodes, lungs, bones, and liver.


Stage II Prostate Cancer AJCC v7

description: Stage II includes: IIA (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X); IIB (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  T2c: Tumor involves both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


Stage IV Cervical Cancer FIGO 2018

description: The cervical carcinoma has extended beyond the true pelvis or has involved (biopsy proven) the mucosa of the bladder or rectum. (A bullous edema, as such, does not permit a case to be allotted to Stage IV). (FIGO 2018)


Encephalopathy of Prematurity

description: A condition affecting premature infants characterized by white matter injury, which is frequently accompanied by neuronal/axonal disease, that may affect all brain parenchymal structures and is due to a combination of destructive processes as well as maturational and trophic disturbances.


Metastatic Bladder Adenocarcinoma

description: Bladder adenocarcinoma that has spread from its original site of growth to other anatomic sites.


Severe Aplastic Anemia

description: Life-threatening anemia associated with a high risk of infection or bleeding.


name: Refractory Extracranial Malignant Solid Neoplasm

description: An extracranial malignant solid neoplasm that is resistant to treatment.


Flat adenoma

description: An adenoma of the gastrointestinal tract mucosa which grossly and morphologically does not appear as an elevated or polypoid lesion.


name: Pathologic Stage III Esophageal Adenocarcinoma AJCC v8

description: Stage III includes: IIIA: (T1, N2, M0, Any G); (T2, N1, M0, Any G); IIIB: (T2, N2, M0, Any G); (T3, N1-2, M0, Any G); (T4a, N0-1, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Early Stage Endometrial Carcinoma

description: A stage term referring to endometrial carcinoma that is confined to the uterus.


name: Ampulla of Vater Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of an ampulla of Vater neuroendocrine tumor according to the American Joint Committee on Cancer, 8th edition. This staging system applies to well-differentiated neuroendocrine tumors of the ampulla of Vater. Carcinomas of the ampulla of Vater, including high-grade (grade 3), poorly differentiated neuroendocrine carcinomas are not included in this staging system. (from AJCC 8th Ed.)


name: Sustained Atrial Tachyarrhythmia Related to COVID-19 other than Atrial Fibrillation or Atrial Flutter

description: A supraventricular tachycardia, including AV nodal re-entry, orthodromic re-entrant tachycardia, multifocal atrial tachycardia, other atrial tachycardia that lasts more then 30 seconds in a patient with probable or confirmed acute COVID-19.


name: Ductal Eccrine Carcinoma with Spindle Cell Elements

description: A variant of ductal eccrine carcinoma with spindled cell appearance.


Pancreatic carcinoma recurrent

description: The reemergence of pancreatic carcinoma after a period of remission.


Seropositive rheumatoid arthritis

description: Rheumatoid arthritis in which a patient's serum is positive for certain disease-related antibodies including anti-cyclic citrullinated peptides (anti-CCPs), also called anti-citrullinated protein antibodies (ACPAs),and rheumatoid factor (RF). Screening for anti-CCPs is more specific than RF which can be found in other pathologic conditions. The production of these disease-associated antibodies may precede the development of clinical symptoms by several years. Seropositive patients have a greater likelihood of developing extra-articular complications and a more severe course of disease.


Spitzoid melanoma

description: A cutaneous melanoma that is associated with genomic alterations observed in Spitz nevus and Spitz melanocytoma. It shares histopathological and clinical features with Spitz melanocytoma.


Diffuse Glioma

description: A glioma that has diffusely infiltrated the surrounding central nervous system tissues.


Acquired Phrenic Nerve Injury

description: Damage to the phrenic nerve that was not present at birth.


name: Vulvar Squamous Intraepithelial Lesion, HPV-Associated

description: An intraepithelial lesion of the vulvar squamous epithelium associated with HPV infection. It is characterized by maturation abnormalities and nuclear hyperchromasia that are confined to the basement membrane.


name: Pathologic Stage IC Esophageal Adenocarcinoma AJCC v8

description: Stage IC includes: (T1, N0, M0, G3); (T2, N0, M0, G1-2). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. G2: Moderately differentiated. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


name: Rhabdomyosarcoma with TFCP2 Rearrangement

description: An aggressive, high-grade rhabdomyosarcoma characterized by TFCP2 rearrangement that results either in TFCP2-FUS or TFCP2-EWSR1 fusion gene formation. It affects young adults and arises from bone and less frequently soft tissue. It predominantly affects the craniofacial bones. Histologically, it usually shows a biphasic pattern with spindle and epithelioid cell areas. It is associated with poor prognosis.


name: Childhood Mixed Cellularity Classic Hodgkin Lymphoma

description: Mixed cellularity classic Hodgkin lymphoma occurring in childhood.


Cebocephaly

description: A congenital abnormality characterized by a malformation of the head. The eyes are hypoteleric and the nose may be absent or misshapen (small, flattened, single nostril) and defective.


Stage I Skin Cancer

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  High-risk features for the primary tumor staging are defined as follows: depth/invasion of more than 2 mm thickness, Clark level equal or greater than IV, and perineural invasion.  Anatomic location: primary site ear and primary site non-hair-bearing lip.  Differentiation: poorly differentiated or undifferentiated.  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th ed.)


Eyelid Function Disorder

description: A disorder characterized by impaired eyelid function.


Stage IVB Prostate Cancer AJCC v8

description: Stage IVB includes: Any T, N0, M1, PSA: Any, Grade Group: Any. N0: Prostate cancer with no positive regional nodes. M1: Prostate cancer with distant metastasis. (AJCC 8th ed.)


Stage IIC Testicular Cancer AJCC v8

description: Stage IIC includes: (Any pT/TX, N3, M0, S0); (Any pT/TX, N3, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Breast Columnar Cell Lesion

description: A morphologic spectrum of lesions that arise in the terminal ductal lobular units of the breast parenchyma.  These lesions are characterized by the presence of columnar epithelial cells that line dilated terminal ductal lobular units.  Cytological and architectural atypia may be absent or minimal, or significant enough to raise the possibility of atypical ductal hyperplasia or ductal carcinoma in situ.  Columnar cell lesions are frequently found in breast biopsies but their biologic significance is not known.


name: Lugano Classification Stage III Adult Hodgkin Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Pre-Gestational Diabetes

description: Diabetes diagnosed before current pregnancy. (reVITALize)


Type II Endometrial Adenocarcinoma

description: A classification of primary endometrial adenocarcinomas that refers to clear cell adenocarcinoma, serous adenocarcinoma, and serous endometrial intraepithelial carcinoma.


Degenerated Schwannoma

description: A schwannoma that is characterized by degenerative changes such as hyalinization, hemorrhage, calcification and cystic change.


name: Advanced Digestive System Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from any part of the digestive system and has spread extensively to other anatomic sites or is no longer responding to treatment.


Embolism

description: The blockage of a blood vessel lumen by air or solid material such as blood clot or other tissues (e.g., adipose tissue, cancer cells) that have migrated from another anatomic site.


name: Unresectable Midgut Neuroendocrine Tumor

description: A midgut neuroendocrine tumor that is not amenable to surgical resection.


Factor II Inactivation

description: Presence of inactivating antibodies to prothrombin (factor II) in the blood.


name: Pathologic Stage IB Esophageal Adenocarcinoma AJCC v8

description: Stage IB includes: (T1a, N0, M0, G2); (T1b, N0, M0, G1-2); (T1b, N0, M0, GX). T1a: Tumor invades the lamina propria or muscularis mucosae. T1b: Tumor invades the submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. G2: Moderately differentiated. (AJCC 8th ed.)


name: Fetus Small for Gestational Age with Abnormal Doppler

description: A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and has abnormal Doppler studies.


name: Metastatic squamous cell carcinoma to skin

description: A squamous cell carcinoma that has spread to the skin from another anatomic site.


name: Peripheral neuropathy due to and following antineoplastic therapy

description: Any disorder affecting the peripheral nerves resulting from exposure to chemotherapeutic agents.


Finding

description: Clinical, laboratory or molecular evidence, or absence of evidence of disease.


name: Type I Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the superior vena cava.


Recurrent Diffuse Midline Glioma

description: The reemergence of diffuse midline glioma after a period of remission.


Childhood Solid Neoplasm

description: A solid neoplasm (e.g., carcinoma, sarcoma) occurring in children.


Metastatic Low Grade Glioma

description: Low grade glioma that has spread from its primary site to another anatomic site.


Unresectable Diffuse Glioma

description: A diffuse glioma that is not amenable to surgical resection.


name: Substance-Induced Persisting Amnestic Disorder

description: A disorder involving memory impairment (either anterograde or retrograde) that is etiologically linked to the persisting effects of substance use. The memory impairment persists beyond the usual duration of substance intoxication or withdrawal.


Platinum-Resistant Urothelial Carcinoma

description: Urothelial carcinoma that is resistant to platinum therapy.


Liver Lymphangiomatosis

description: Multiple lymphangiomas that affect the liver and other anatomic sites. Although histologically benign, diffuse lymphangiomatosis that affects the liver and multiple organs has a poor prognosis.


name: Supratentorial Ependymoma, Not Otherwise Specified

description: A circumscribed ependymoma that arises from the supratentorial region of the brain in which the genetic analysis for fusion genes involving ZFTA or YAP1 genes was unsuccessful or not reported.


Stage II Merkel Cell Carcinoma AJCC v7

description: Stage II includes: IIA: (T2/T3, pN0, M0), IIB: (T2/T3, cN0, M0), and IIC: (T4, N0, M0).  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  T4: Primary tumor invades bone, muscle, fascia, or cartilage.  pN0: No regional lymph node metastasis by pathologic examination.  cN0: No regional lymph node metastasis by clinical examination.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Vital Exhaustion

description: A condition characterized by excessive fatigue and lack of energy, increasing irritability, and feelings of demoralization. Persons who experience this condition are not at an increased risk for cancer.


name: Recurrent Anal Canal Squamous Cell Carcinoma

description: The reemergence of anal canal squamous cell carcinoma after a period of remission.


Stage IIA1 Cervical Cancer FIGO 2009

description: Cervical carcinoma limited to the upper two-thirds of the vagina and is equal or less than 4 cm in diameter. (FIGO 2009)


Non-Neoplastic Muscle Disorder

description: A non-neoplastic disorder that affects the smooth, skeletal, or cardiac muscles.


Vaginal Adenoid Basal Carcinoma

description: A carcinoma that arises from the vagina and is characterized by the presence of nests of basaloid cells with focal glandular formations.


Retinoblastoma by AJCC v8 Stage

description: A term that refers to the staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition. This staging system does not apply to central nervous system component of "trilateral retinoblastoma" (is staged according to the classification for brain and spinal cord), retinoma (or retinocytoma) (no AJCC staging system), and medulloepithelioma (no AJCC staging system). (from AJCC 8th Ed.)


name: Unresectable Distal Esophagus Adenocarcinoma

description: Distal esophagus adenocarcinoma that is not amenable to surgical resection.


Thoracoschisis

description: A congenital fissure of the thoracic wall.


name: Intraepithelial Neoplasia in Barrett Esophagus

description: Glandular intraepithelial neoplasia arising in Barrett esophagus.


Small plaque parapsoriasis

description: A variant of parapsoriasis in which the plaques are small.


name: Advanced Digestive System Neuroendocrine Tumor G2

description: Digestive system neuroendocrine tumor G2 that has spread extensively to other anatomic sites or is no longer responding to treatment.


Gallbladder Cribriform Carcinoma

description: A rare variant of gallbladder adenocarcinoma.  It is characterized by the presence of a malignant glandular epithelial infiltrate with a cribriform growth pattern.


name: Accelerated Phase Myeloproliferative Neoplasm

description: Rapid progression of a myeloproliferative neoplasm, characterized by the presence of myeloblasts accounting for 10-19% of the peripheral blood white cells or the nucleated cells in the bone marrow.


name: Refractory EBV-Related Lymphoproliferative Disease with Primary Immunodeficiency

description: EBV-associated lymphoproliferative disease with primary immunodeficiency that is resistant to treatment.


Overt Primary Myelofibrosis

description: Primary myelofibrosis characterized by reticulin or collagen fibrosis in the bone marrow. The bone marrow is usually normocellular or hypocellular. Myeloblasts account for less than 10% of the bone marrow cells. Atypical megakaryocytes are present.


Radiating Chest Pain in Sternum

description: The location of the radiating chest pain is in the middle of the anterior wall of the thorax, bounded by the clavicles, above, and with the cartilages of the first seven ribs, along the sides.


name: Stage IIIC2 Uterine Corpus Cancer AJCC v7

description: Stage IIIC2 includes: T1-T3, N2, M0. T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue.  N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Tumor Pain

description: A painful sensation caused by the tumor growth.


Acute Myeloid Leukemia with del(12p)

description: Acute myeloid leukemia associated with deletion of the short arm of chromosome 12 [del(12p)].


Mucosal-Dominant Pemphigus Vulgaris

description: A subtype of pemphigus vulgaris in which lesions are predominantly found on mucosal membranes with relative sparing of cutaneous tissues.


Metastatic Biliary Tract Carcinoma

description: A biliary tract carcinoma that has spread from the original site of growth to other anatomic sites.


Cervical Glandular Neoplasm

description: A benign, malignant, or precancerous neoplasm that arises from the glandular epithelium of the cervix. Representative examples include endocervical polyp, cervical adenocarcinoma, and cervical glandular intraepithelial neoplasia.


name: Metastatic Bladder Micropapillary Urothelial Carcinoma

description: Bladder micropapillary urothelial carcinoma that has spread to another anatomic site.


name: Lugano Classification Advanced Stage Adult Hodgkin Lymphoma AJCC v8

description: Advanced stage adult Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


Stage IIA Cervical Cancer FIGO 2018

description: Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement. (FIGO 2018)


Behavioral insomnia of childhood

description: A childhood disorder characterized by difficulty initiating and maintaining sleep due to negative sleep associations, refusal to go to bed, and/or repeated attempts to delay bedtime.


name: Malignant Central Nervous System Germ Cell Tumor

description: A germ cell tumor that affects the central nervous system, characterized by the presence of malignant morphologic characteristics.  Representative examples include choriocarcinoma, embryonal carcinoma, and germinoma.


Hodgkin's lymphoma of CNS

description: A Hodgkin lymphoma that arises from the central nervous system.


Vaginal Mucinous Adenocarcinoma

description: A rare adenocarcinoma that arises from the vagina with histologic features resembling cervical mucinous adenocarcinoma.


Posterior Subcapsular Cataract Grade 1

description: A stage of posterior subcapsular cataract characterized by 3% of the posterior capsule obscured by opacity. (Modified LOCS II)


Infant Acute Lymphoblastic Leukemia

description: An acute lymphoblastic leukemia that occurs in infancy.


name: Simple Endometrial Hyperplasia without Atypia

description: A proliferation of endometrial cells resulting in glandular enlargement and budding without changes in the basic structure of the endometrium. Epithelial atypia is absent.


name: Locally Advanced Epithelioid Hemangioendothelioma

description: An epithelioid hemangioendothelioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Neonatal Deformity

description: A congenital anatomic abnormality manifested during the neonatal period.


name: Stage IIIB Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of lymph node regions on both sides (above and below) of the diaphragm. This may be accompanied by extra-lymphatic extension in association with adjacent lymph node involvement (i.e., local extension from a lymph node area into a nearby organ) and/or involvement of spleen. The medical record states there are constitutional symptoms. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Breast Papillary Ductal Hyperplasia

description: Benign papillary proliferation within the ductal system of the breast parenchyma.


Benign Urinary Tract Neoplasm

description: A neoplasm that arises from the organs that comprise the urinary tract and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Somatic-Type Malignancy

description: A malignant non-germ cell component that typically develops secondarily within a germ cell tumor. The malignant cellular component is usually sarcomatous or carcinomatous.


Stage IIB Pancreatic Cancer AJCC v8

description: Stage IIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. N1: Metastasis in one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Postoperative Spindle Cell Nodule of the Bladder

description: A benign, reactive lesion of the bladder, occurring status post bladder instrumentation; histologic exam demonstrates a fascicular growth pattern of plump or elongated spindle cells infiltrating the bladder wall without atypia or necrosis.


Microinvasive Anal Carcinoma

description: Anal carcinoma with minimal stromal invasion.


Melanoma of Unknown Primary

description: A melanoma which has metastasized from an unknown primary anatomic site.


Unresectable Malignant Neoplasm

description: A malignant neoplasm which is not amenable to surgical resection.


Stage IV Osteosarcoma AJCC v7

description: Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Neonatal apneic attack

description: Apnea occurring during the neonatal period.


name: Locally Advanced Pancreatic Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IIIB Appendix Carcinoma AJCC v7

description: Stage IIIB includes: (T3, N1, M0); (T4, N1, M0). T3: Tumor invades through the muscularis propria into subserosa or into mesoappendix.  T4: Tumor penetrates visceral peritoneum including mucinous peritoneal tumor within the right lower quadrant and/or directly invades other organs or structures.  N1: Metastasis in 1-3 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Dialysis Catheter Embolism

description: An obstruction of a vessel caused by a detached fragment of an indwelling dialysis catheter.


name: Pathologic Stage 0 Cutaneous Melanoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Fusion-Negative Rhabdomyosarcoma

description: A rhabdomyosarcoma characterized by the absence of chromosomal translocation t(1;13)(p36;q14) or t(2;13)(q35;q14) and therefore the absence of PAX7-FOXO1 or PAX3-FOXO1 gene fusion.


name: Metastatic Bladder Squamous Cell Carcinoma

description: Bladder squamous cell carcinoma that has spread to another anatomical site.


name: Transplant-Related Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises in a patient with a history of organ transplantation.


Refractory Anaplastic Oligodendroglioma

description: An anaplastic oligodendroglioma that is resistant to treatment.


name: Acute Myeloid Leukemia with Mutated TP53

description: Acute myeloid leukemia characterized by the presence of TP53 gene mutations. There are 20% or more blasts in bone marrow or peripheral blood.


Accessory Urethral Gland Neoplasm

description: A benign or malignant, primary or metastatic neoplasm affecting the accessory urethral gland.


Stage II Gallbladder Cancer AJCC v6

description: Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N0, M0); (T2, N0, M0); (T3, N0, M0).  T2: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, or pancreas, omentum or extrahepatic bile ducts. (AJCC 6th ed.)


name: Ampulla of Vater Undifferentiated Carcinoma

description: An aggressive carcinoma arising from the ampulla of Vater.  Morphologically, it is characterized by the presence of malignant epithelial cells without evidence of glandular or squamous differentiation.  Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss.


name: Clinical Stage II Retinoblastoma AJCC v8

description: Stage II includes: cT4a, cN0, cM0, Any H. cT4a: Radiologic evidence of retrobulbar optic nerve involvement or thickening of optic nerve or involvement of orbital tissues. cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Peripheral Hemangioblastoma

description: A hemangioblastoma that arises from peripheral nerves or extraneural tissues.


Non-Ossifying Fibroma

description: A tumor histologically indistinguishable from, but larger than, benign fibrous histiocytoma of bone.


Stage IB1 Cervical Cancer AJCC v8

description: Stage IB1 includes: T1b1, Any N, M0. T1b1: Tumor with clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Cervical Cancer AJCC v8

description: Stage IIA includes: T2a, Any N, M0. T2a: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


BRCA-Associated Malignant Neoplasm

description: A malignant neoplasm caused by deleterious germline mutation in a gene of the BRCA family.


Tachyarrhythmia

description: A disorder characterized by an arrhythmia with an above normal rate.


name: Recurrent Low Grade Endometrioid Adenocarcinoma

description: The reemergence of low-grade endometrioid adenocarcinoma after a period of remission.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Tier 1, International Society of Pediatric Oncology (SIOP) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the tier 1 Toronto childhood cancer staging guidelines v2, International Society of Pediatric Oncology (SIOP) protocol.


Benign Apocrine Neoplasm

description: An epithelial neoplasm that arises from the apocrine glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Non-Neoplastic Tracheal Disorder

description: A non-neoplastic disorder that affects the trachea.  Representative examples include tracheitis, tracheal agenesis, and tracheal atresia.


Gastroblastoma

description: A very rare biphasic tumor arising in the gastric muscularis propria (usually of the antrum), generally in boys and young men. It is associated with MALAT1-GLI1 gene fusion. (WHO 2019)


Cheilognathoschisis

description: A congenital abnormality consisting of a fissure in the midline of the lip and upper jaw.


Villous Adenoma of the Urinary Tract

description: An exophytic glandular neoplasm of the urinary tract, morphologically similar to its intestinal counterpart. It usually arises from the bladder and urachus. It often coexists with in situ or infiltrating bladder adenocarcinoma.


Primary Cutaneous NUT Adnexal Carcinoma

description: A very rare carcinoma that arises from adnexal structures in the skin. It is characterized by mutations and rearrangement of the NUT gene. It presents as a papular or nodular lesion and has been described in the hand, shoulder, trunk, and lower limb. Histologically, there is a proliferation of malignant epithelial cells in the dermis and/or subcutaneous tissue. The tumor cells display round nuclei with prominent single nucleoli. Features include the presence of small round ducts and foci of abrupt keratinization.


Hemoglobin Trait

description: A condition in which a person is heterozygous for a globin gene, with a one normal allele and one defective allele.


HIV lipodystrophy

description: A neoplastic process characterized by a diffuse poorly circumscribed overgrowth of adipose tissue in the breast and cervical areas, and an accumulation of visceral fat.  It is associated with antiretroviral therapy.  Clinical presentation includes hyperlipidemia, insulin resistance, and fat atrophy of the face and limbs.


Cortical Cataract Grade 1

description: A stage of cortical cataract characterized by 10% of the intrapupillary space obscured by opacity. (Modified LOCS II)


Stage I Uterine Corpus Cancer AJCC v6

description: Stage I includes: I (T1, N0, M0); IA: (T1a, N0, M0); IB (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor confined to corpus uteri. T1a: Tumor limited to the endometrium.  T1b: Tumor invades less than one-half of the myometrium.  T1c: Tumor invades one-half or more of the myometrium.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Acute synovitis

description: An acute inflammation of a synovial membrane. It is associated with swelling and pain in the affected area.


Stage IIB Anal Cancer AJCC v8

description: Stage IIB includes: T3, N0, M0. T3: Tumor larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Mucosal Melanoma

description: Mucosal melanoma that has spread from its primary site to another anatomic site.


name: Recurrent Childhood Anaplastic Oligodendroglioma

description: The reemergence of anaplastic oligodendroglioma in childhood after a period of remission.


name: Malignant neoplasm arising from pre-existing spiradenocylindroma

description: A carcinoma that arises in a spiradenocylindroma.


name: Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with High Grade Dysplasia

description: An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized by the presence of high grade dysplasia.


Lithium Induced Birth Defect

description: Congenital abnormalities, mainly cardiovascular malformations, which develop in a fetus when the mother uses lithium medication during pregnancy.


name: Metastatic Vaginal Squamous Cell Carcinoma

description: Vaginal squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


name: Platinum-Refractory Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that progresses during platinum therapy or within one month of completing platinum therapy.


Factor XII Inactivation

description: Presence of inactivating antibodies to factor XII in the blood.


name: Papillary cystadenoma, borderline malignancy

description: A serous or mucinous cystic glandular epithelial neoplasm of low malignant potential. It is characterized by the presence of atypical or malignant glandular epithelial cells forming papillary structures with an absence of stromal invasion.


name: Metastatic Unresectable Malignant Neoplasm

description: A malignant neoplasm that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


name: Benign Outer Hair Sheath and Infundibulum Neoplasm

description: A neoplasm that arises from the outer hair sheath and infundibulum. It is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Female Reproductive System Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle neoplasm that arises from any part of the female reproductive system and cannot be reliably diagnosed as benign or malignant because of the presence of ambiguous morphologic findings.


Non-Neoplastic Splenic Disorder

description: A non-neoplastic disorder that affects the spleen.


SUR1-Associated Diabetes Mellitus

description: Diabetes mellitus caused by activating mutation(s) in the ABCC8 gene, encoding the sulfonylurea receptor 1 (SUR1) subunit of the pancreatic beta cell adenosine triphosphate-sensitive potassium channel. Note: Inactivating mutation(s) in the ABCC8 gene result in hyperinsulinism.


Acute Myeloid Leukemia with del(5q)

description: Acute myeloid leukemia associated with deletion of the long arm of chromosome 5 [del(5q)].


Stabbing Pain

description: An intense sensation of discomfort or distress that is sharp and feels as though a knife has penetrated an anatomical location.


name: Acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22) CBFB-MYH11

description: An acute myeloid leukemia with monocytic and granulocytic differentiation and the presence of a characteristically abnormal eosinophil component in the bone marrow.  This type of acute myeloid leukemia has a favorable prognosis.  (WHO, 2001)


name: Mucosal Melanoma of the Female Genital Tract

description: A malignant melanocytic neoplasm that arises from a mucosal site of the female genital tract.


Perineal Pain

description: Painful sensation in the perineal area.


name: immune effector cell-associated neurotoxicity syndrome, grade 1

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 7, 8, or 9 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of less than 9 (for children 12 and under), and the ability of the affected individual to awaken spontaneously.


name: Metastatic Extracranial Malignant Solid Neoplasm

description: A malignant solid neoplasm that arises from any anatomic site other than the brain and has spread from its original site of growth to another anatomic site.


name: IgG4-Positive Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: A primary cutaneous marginal zone lymphoproliferative disorder characterized by the presence of class-switched immunoglobulin heavy chain expressing IgG4.


name: Transitional Cell Intraepithelial Neoplasia


Abscess of axilla

description: A collection of pus that has formed in the axilla.


Atheroembolism of renal arteries

description: A cholesterol plaque embolus that has become lodged in the renal vasculature.


name: Malignant Lacrimal Drainage System Neoplasm

description: A primary or metastatic malignant neoplasm that affects the lacrimal drainage system.


Parasite-Related Malignant Neoplasm

description: A malignancy in which there is a well-documented association between a neoplastic process and a specific parasite as the causative agent.


name: Gastroesophageal Junction Small Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction.  It is characterized by the presence of malignant small cells.


name: Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8

description: Stage IVA includes: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Regional Childhood Retinoblastoma by Toronto Guidelines v2

description: Orbital extension or regional lymph nodes involvement. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Monoclonal B-Cell Lymphocytosis

description: A monoclonal expansion of B-lymphocytes with or without the characteristic immunophenotype of chronic lymphocytic leukemia. It precedes virtually all cases of chronic lymphocytic leukemia/small lymphocytic lymphoma.


Recurrent Adenocarcinoma

description: An adenocarcinoma that has recurred after a period of remission.


name: intraepithelial glandular neoplasia of cervix

description: A neoplastic process that affects the glandular epithelial cells of the cervix.  There is no evidence of invasion.  It is classified as low or high grade.


name: Advanced Childhood Malignant Solid Neoplasm

description: A childhood malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Squamous Cell Carcinoma

description: Squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Radiation-Related Angiosarcoma

description: A malignant vascular neoplasm arising in an anatomic site exposed to radiation therapy.


name: Nutritional Vitamin D Deficiency Rickets

description: Nutritional rickets due to dietary deficiency of vitamin D.


Ureteral Kinking

description: The folding of a ureter, which results in the impediment of urine flow.


Urethral caruncle

description: A benign, granulomatous lesion that results from the eversion of a portion of the distal urethra, most often at the posterior edge.


Pancreatic Precancerous Condition

description: A pathologic process that arises from the pancreas and has the potential to evolve into a malignant neoplasm.


Stage III Appendix Carcinoma AJCC v8

description: Stage III includes: IIIA: (T1, N1, M0); (T2, N1, M0); IIIB: (T3, N1, M0); (T4, N1, M0); IIIC: (Any T, N2, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4: Tumor invades the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or mesoappendix, and/or directly invades adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. N2: Four or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Merkel Cell Carcinoma

description: The reemergence of Merkel cell carcinoma after a period of remission.


Acute rheumatic endocarditis

description: Inflammation of the endocardium in acute rheumatic heart disease.


Refractory Spindle Cell Sarcoma

description: Spindle cell sarcoma that is resistant to treatment.


Stage I Vulvar Cancer AJCC v6

description: Stage I includes: T1, N0, M0. T1: Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.).


Refractory Ampulla of Vater Carcinoma

description: Ampulla of Vater carcinoma that is resistant to treatment.


name: Acute Myeloid Leukemia with EZH2 Mutation

description: An acute myeloid leukemia associated with EZH2 gene mutation.


name: Stage II Pancreatic Cancer AJCC v6 and v7

description: Stage II includes: IIA (T3, N0, M0); IIB (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Tumor limited to the pancreas 2 cm or less in greatest dimension.  T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension. T3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery.  N0: No regional lymph node metastasis. N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


Visual Pathway Melanocytoma

description: A benign neoplastic melanocytic proliferation affecting the optic disk and optic nerve.


name: Metastatic Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that has spread from its original site of growth to other anatomic sites.


name: Recurrent Childhood Acute Lymphoblastic Leukemia

description: The reemergence of acute lymphoblastic leukemia in childhood after a period of remission.


name: Childhood Diffuse Astrocytoma, MYBL1-Altered

description: A rare diffuse astrocytoma, MYBL1-altered that occurs during childhood.


Appendix Intraepithelial Neoplasia

description: A precancerous intraepithelial neoplastic lesion that affects the appendix. It is characterized by low or high grade dysplasia of the mucosal epithelium.  There is no evidence of invasion.


Vaginal intraepithelial neoplasia

description: A superficial neoplastic process involving exclusively the vaginal squamous epithelium without extension to underlying tissue.  It is classified as low- or high-grade intraepithelial neoplasia.


Recurrent Sarcoma

description: The reemergence of sarcoma after a period of remission.


Traumatic hemorrhage

description: Vascular rupture, and the resulting loss of blood, due to physical injury.


Locally Advanced Glioma

description: Glioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Infective conjunctivitis

description: An infectious process affecting the conjunctiva.


Acute Cerebrovascular Accidents

description: The sudden or severe onset of neurological deficit(s) attributable to an acute focal vascular injury of the central nervous system.


Childhood Grade III Meningioma

description: A grade III meningioma that occurs during childhood.


name: Refractory Juvenile Myelomonocytic Leukemia

description: Juvenile myelomonocytic leukemia that is resistant to treatment.


Benign Lymphoproliferative Disorder

description: A proliferation of lymphocytes without atypia seen in infections, hypersensitivity reactions or autoimmune diseases.


Bronchial Epithelial Hyperplasia

description: Hyperplasia of the bronchial epithelial cells.  It is often associated with squamous metaplasia.


Inverted Squamous Cell Papilloma

description: A benign epithelial neoplasm characterized by an endophytic growth, papillary pattern, and proliferation of neoplastic squamous cells without morphologic evidence of malignancy.


name: Refractory Endometrial Mixed Cell Adenocarcinoma

description: Endometrial mixed cell adenocarcinoma that is resistant to treatment.


description: A non-neoplastic disorder arising in an anatomic site exposed to radiation.


Refractory Malignant Solid Neoplasm

description: A malignant solid neoplasm that does not respond to treatment.


Unresectable Bone Sarcoma

description: Bone sarcoma that is not amenable to surgical resection.


name: Childhood Nodular Sclerosis Classic Hodgkin Lymphoma

description: Nodular sclerosis classic Hodgkin lymphoma occurring in childhood.


name: Stage IIB Ampulla of Vater Cancer AJCC v8

description: Stage IIB includes: T3b, N0, M0. T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Advanced Malignant Testicular Germ Cell Tumor

description: A malignant testicular germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IIIB includes: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Delusional disorder, jealous type

description: A subtype of delusional disorder characterized by the central delusional theme that the individual's spouse or lover is unfaithful.


name: Immune Effector Cell Associated Neurotoxicity Syndrome Grade 5

description: Death due to Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) where another cause is not the primary determinant.


Childhood Astrocytoma

description: An astrocytoma that occurs during childhood.


name: Advanced Large Cell Neuroendocrine Carcinoma

description: Large cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Gastroesophageal Junction Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Lymph Node Pain

description: A painful sensation in a lymph node.


name: Stage 0 Low Grade Appendix Mucinous Neoplasm (LAMN) AJCC v8

description: Stage 0 includes: Tis(LAMN), N0, M0. Tis(LAMN): Low-grade appendiceal mucinous neoplasm confined by the muscularis propria. Acellular mucin or mucinous epithelium may invade into the muscularis propria. T1 and T2 are not applicable to LAMN. Acellular mucin or mucinous epithelium that extends into the subserosa or serosa should be classified as T3 or T4a, respectively. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Hodgkin's disease nodular sclerosis recurrent

description: The reemergence of nodular sclerosis classic Hodgkin lymphoma after a period of remission.


Metastatic Urachal Urothelial Carcinoma

description: Bladder urachal urothelial carcinoma that has spread to another anatomic site.


Stage IIIC Prostate Cancer AJCC v8

description: Stage IIIC includes: Any T, N0, M0, PSA: Any, Grade Group 5. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 5: Gleason Score 9 or 10, Gleason Pattern 4+5, or 5+4, or 5+5. (AJCC 8th ed.)


Stage III Prostate Cancer AJCC v6

description: Stage III includes: T3, N0, M0, Any G. T3: Tumor extends through the prostatic capsule.  T3a: Extracapsular extension (unilateral or bilateral).  T3b: Tumor invades seminal vesicle(s). N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Cramping Pain

description: A sense of discomfort or distress that is spasmodic or clenching.


name: Metastatic Digestive System Neuroendocrine Tumor

description: A digestive system neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


name: Stage IV Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Hematogenous metastases or spread beyond abdomen at diagnosis. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage III Uterine Corpus Cancer

description: Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T1-T3, N1/N2, M0); IIIC1 (T1-T3, N1, M0); IIIC2 (T1-T3, N2, M0). T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. T3a: Tumor involves serosa and/or adnexa (direct extension or metastasis). T3b: Tumor involves vagina (direct extension or metastasis) or parametrial tissue. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Infantile Myofibroma

description: A benign, localized, nodular and well-circumscribed neoplasm seen as a congenital neoplasm or in the first year of life. It is characterized by a biphasic growth pattern and is composed of small, undifferentiated mesenchymal cells associated with branching thin-walled vessels and more mature neoplastic spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma.


Radiologic Finding

description: Imaging results obtained through a radiology procedure.


name: Vulvar Large Cell Neuroendocrine Carcinoma

description: A high grade neuroendocrine carcinoma that arises from the vulva. It is characterized by the presence of malignant large cells.


BAP1-inactivated melanocytoma

description: A cutaneous melanocytoma caused by the inactivation of BAP1 tumor suppressor gene. It is characterized by the presence of a predominantly intradermal proliferation of large epithelioid melanocytes with a large amount of eosinophilic cytoplasm, and vesicular nuclei with prominent nucleoli. Progression to melanoma is infrequent.


name: Recurrent Malignant Female Reproductive System Neoplasm

description: The reemergence of a malignant female reproductive system neoplasm after a period of remission.


Bilateral Carcinoma

description: A carcinoma that affects both sides of an organ in a simultaneous or non-simultaneous manner.


Stage IVA Bone Cancer AJCC v8

description: Stage IVA includes: Any T, N0, M1a, Any G. N0: No regional lymph node metastasis. M1a: Metastasis in the lung. (AJCC 8th ed.)


name: Squamous cell carcinoma, small cell, nonkeratinizing

description: A squamous cell carcinoma composed of small atypical cells, without morphologic evidence of keratin production.


Unresectable Biliary Tract Carcinoma

description: Biliary tract carcinoma that is not amenable to surgical resection.


Acute Myeloid Leukemia with FIP1L1-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of FIP1L1-RARA fusion protein.


Prostate Cystadenoma

description: A rare cystadenoma affecting the prostate gland. It is characterized by the presence of multilocular prostatic cysts.


Metastatic glioma

description: Glioma that has spread from its original site of growth to another anatomic site.


name: Poor Prognosis Metastatic Gestational Trophoblastic Tumor

description: Metastatic gestational trophoblastic tumor in which risk factors are present.


Hodgkin Lymphoma During Pregnancy

description: Hodgkin lymphoma that occurs during pregnancy.


name: Vaginal Adenocarcinoma of Skene Gland Origin

description: A rare vaginal adenocarcinoma arising from the Skene gland. It is characterized by morphological and immunohistochemical features similar to prostate adenocarcinoma.


Thoracic meningomyelocele

description: A congenital abnormality in the thoracic region of the spine, in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Adenocarcinoma of the prostate stage IV

description: Stage IV includes: (T4, N0, M0, Any PSA, Any Gleason); (Any T, N1, M0, Any PSA, Any Gleason); (Any T, Any N, M1, Any PSA, Any Gleason). cT4: Tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall.  pT4: Invasion of rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 7th ed.)


Central Nervous System Hamartoma

description: A hamartoma that occurs in the central nervous system.


Advanced Malignant Solid Neoplasm

description: A malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Dermatitis due to unspecified substance taken internally

description: Dermatitis caused by an allergic reaction to an unspecified ingested substance.


Advanced Fibrosarcoma

description: Fibrosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Cutaneous Erdheim-Chester Disease

description: Erdheim-Chester disease that affects the skin.


Conventional Alveolar Rhabdomyosarcoma

description: An alveolar rhabdomyosarcoma characterized by the presence of large striated muscle cells with clear cytoplasm, giant cells with myoblastic differentiation, and fibrovascular septa.


name: Stage IIIC Fallopian Tube Cancer AJCC v7

description: Stage IIIC includes: (T3c, N0, M0); (Any T, N1, M0).  T3c: Peritoneal metastasis outside the pelvis and more than 2 cm in diameter.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Congenital Varicella Zoster Infection

description: An infection, characterized by the rash of chickenpox or shingles, that is caused by the varicella-zoster virus transmitted directly from the mother to the fetus or neonate during late pregnancy or childbirth.


name: Plasmacytic Hyperplasia Post-Transplant Lymphoproliferative Disorder

description: An early post-transplant lymphoproliferative lesion characterized by plasmacytic proliferation and architectural preservation of the involved tissues.  It often regresses either spontaneously or after reduction in immunosuppression.  The immunoglobulin genes are not rearranged.  In some cases, a polymorphic or monomorphic post-transplant lymphoproliferative disorder may follow this early lesion.


name: Hodgkin's disease nodular sclerosis stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Retroperitoneal abscess

description: An abscess that is located in the abdominal cavity posterior to the peritoneum.


Confusion, Post-Ictal

description: A period of confusion following a seizure in which the patient does not respond appropriately despite appearing awake.


name: Stage II Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of two or more lymph node regions on the same side (either above or below) of the diaphragm or localized involvement of a single extra-lymphatic organ or site in association with regional lymph node involvement (i.e., local extension from a lymph node area into a nearby organ), with or without involvement of other contiguous lymph node regions on the same side (either above or below) of the diaphragm. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Unresectable Transitional Cell Carcinoma

description: A transitional cell carcinoma which is not amenable to surgical resection.


Congenital Intrahepatic Biliary Atresia

description: A congenital disorder characterized by blockage or absence of the intrahepatic bile ducts.


Recurrent Cytomegalovirus Infection

description: A cytomegalovirus infection that has recurred after a period of remission.


name: Childhood Benign Digestive System Neoplasm

description: A childhood neoplasm that arises from the digestive system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Recurrent Extrapulmonary Neuroendocrine Carcinoma

description: The reemergence of extrapulmonary neuroendocrine carcinoma after a period of remission.


Unresectable Angiosarcoma

description: An angiosarcoma that is not amenable to surgical resection.


name: Reactive Epithelial Hyperplasia of the Ciliary Body

description: An increase in cell number and volume of the ciliary epithelium, usually in response to injury. (WHO 2018)


Lacrimal Drainage System Adenocarcinoma

description: An adenocarcinoma that arises from the lacrimal sac or nasolacrimal duct.


name: Refractory Epithelioid Malignant Peripheral Nerve Sheath Tumor

description: An epithelioid malignant peripheral nerve sheath tumor that does not respond to treatment.


No Cardiac Valve Regurgitation

description: No evidence of any retrograde blood flow through the valve(s) in the heart. (ACC)


name: Lacrimal Drainage System Inverted Papilloma

description: A benign neoplasm of the lacrimal drainage system characterized by an inverted/endophytic or mixed growth pattern. It is the most common epithelial neoplasm of the lacrimal drainage system. (WHO 2018)


Locally Recurrent Endometrial Carcinoma

description: The reemergence of endometrial carcinoma after a period of remission, at or adjacent to the site of the original tumor.


description: A hepatocellular adenoma caused by activating mutations of beta-catenin.  It is characterized by the presence of nuclear atypia and absence of inflammation or steatosis.  There is an increased risk of malignant transformation.


name: Ancylostomiasis due to Ancylostoma duodenale

description: Ancylostomiasis that is caused by infection by Ancylostoma Duodenale.


Stage IV Childhood Hodgkin Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Stage IB Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of a single lymph node region or involvement of a single extra-lymphatic organ or site, without lymph node involvement. The medical record states there are constitutional symptoms. This definition applies to both tiers (tier 1 and 2).  (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Acute Myeloid Leukemia with RAM Immunophenotype

description: A high risk pediatric acute myeloid leukemia with an extremely poor prognosis. The blasts show bright CD56 expression, dim-to-negative expression of CD45 and CD38, and lack of HLA-DR expression. This immunophenotype was named after one of the pediatric patient's initials (RAM), from Children's Oncology Group (COG) clinical trial AAML0531.


Vaginal Endometrioid Adenocarcinoma

description: A rare adenocarcinoma that arises from the vagina with histologic features resembling the endometrioid adenocarcinoma of the endometrium.


Late Disseminated Lyme Disease

description: A late stage of Lyme disease that may present in untreated patients months to years after a tick bite manifested with intermittent bouts of arthralgia, arthritis and neurologic complaints.


name: Cervical Squamous Cell Carcinoma, Not Otherwise Specified

description: Cervical squamous cell carcinoma in which information on the p16 immunohistochemistry or HPV testing status is not available.


name: Chest Pain in Left Third Intercostal Space

description: The location of the chest pain is within the third intercostal space on the left side.


Stage IIB Prostate Cancer AJCC v7

description: Stage IIB includes: (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T2c: Tumor involves both lobes.  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


Dialysis Catheter Infection

description: A local or systemic infection associated with the use of a dialysis catheter.


name: Recurrent Pancreatic Ductal Adenocarcinoma

description: The reemergence of pancreatic ductal adenocarcinoma after a period of remission.


Vaginal Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the vagina. Representative examples include vaginal infection and vaginal fibroepithelial polyp.


Malignant neoplasm of stomach stage II

description: Stage II includes: IIA (T3, N0, M0); (T2, N1, M0); (T1, N2, M0); IIB (T4a, N0, M0); (T3, N1, M0); (T2, N2, M0); (T1, N3, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


Nasal Chondromesenchymal Hamartoma

description: A very rare benign lesion that arises from the sinonasal tract. It usually affects infants and children. It presents as a polypoid mass and is composed of cartilage, myxoid stroma, and other mesenchymal elements.


Puerperal endometritis

description: Infection of the endometrium, decidua and/or myometrium occurring at any time between birth and 42 days postpartum.


name: Stage IV Pancreatic Neuroendocrine Tumor AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Biliary Intraepithelial Neoplasia

description: A neoplastic, non-invasive lesion that affects the biliary epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


Hypertensive Urgency

description: Hypertensive crisis without end-organ damage.


Recurrent Anaplastic Ganglioglioma

description: The reemergence of anaplastic ganglioglioma after a period of remission.


Adrenoleukodystrophy, Neonatal

description: A rare metabolic disorder that affects neonates. It is characterized by damage of the white matter in the brain and degeneration of the adrenal glands. It manifests with hyperactivity, paralysis, muscular weakness, crossed eyes, hearing loss, seizures, and coma.


Cribriform comedo-type adenocarcinoma

description: An adenocarcinoma characterized by the presence of malignant cribriform glands with central necrotic changes.