name: Sparsely Granulated Corticotroph Pituitary Neuroendocrine Tumor

description: A corticotroph pituitary neuroendocrine tumor composed of faintly basophilic or chromophobic PAS-positive cells with weak or patchy positivity for ACTH, consistent with the scant, small secretory granules seen ultrastructurally. (WHO)


Atypical Pituitary Neuroendocrine Tumor

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A usually aggressive and invasive pituitary neuroendocrine tumor characterized by excessive p53 immunoreactivity, increased mitotic activity, and MIB-1 proliferative index greater than 3%.


name: Densely Granulated Somatotroph Pituitary Neuroendocrine Tumor

description: A growth hormone-producing pituitary neuroendocrine tumor composed of medium-sized acidophilic cells with granular cytoplasm and abundant secretory granules.


description: A pituitary neuroendocrine tumor with a diameter equal or less than 10 mm.


name: Multiple Synchronous Pituitary Neuroendocrine Tumors of Distinct Lineages

description: Multiple pituitary neuroendocrine tumors composed of adenohypopheseal cells of two or more lineages or a null cell tumor in combination with a lineage-specific pituitary neuroendocrine tumor in the same gland.


name: Non-Functioning Sparsely Granulated Corticotroph Pituitary Neuroendocrine Tumor

description: A sparsely granulated corticotroph pituitary neuroendocrine tumor not associated with a hormonal syndrome.


name: Nasopharyngeal Pituitary Neuroendocrine Tumor

description: An ectopic pituitary neuroendocrine tumor that arises from the nasopharynx.


name: Mixed Gangliocytoma-Pituitary Neuroendocrine Tumor

description: A pituitary neoplasm composed of mature ganglionic cells admixed with pituitary neoplastic neuroendocrine cells.


name: ATP-binding cassette sub-family G member 1 isoform 4 (human)

description: An ATP-binding cassette sub-family G member 1 isoform 4 that is encoded in the genome of human.


name: ubiquitin-like domain-containing CTD phosphatase 1

description: A protein that is a translation product of the human UBLCP1 gene or a 1:1 ortholog thereof.


name: ubiquitin-like domain-containing CTD phosphatase 1 isoform 1 (human)

description: A ubiquitin-like domain-containing CTD phosphatase 1 isoform 1 that is encoded in the genome of human.


tetraspanin-1 N-glycosylated 1 (human)

A tetraspanin-1 (human) that has been N-glycosylated at the residue equivalent to Asn-154 of the amino acid sequence represented by UniProtKB:O60635-1, in which the glycan composition is represented by GlyTouCan:G01650EU. Example: UniProtKB:O60635-1, Asn-154, MOD:00160~GNO:G01650EU.


tetraspanin-1 isoform 1 (human)

A tetraspanin-1 isoform 1 that is encoded in the genome of human.


name: follitropin subunit beta N-glycosylated 5 (human)

description: A follitropin subunit beta (human) that has been N-glycosylated at the residue equivalent to Asn-42 of the amino acid sequence represented by UniProtKB:P01225-1, in which the glycan structure is represented by GlyTouCan:G05850WN. Example: UniProtKB:P01225-1, Asn-42, MOD:00160~GNO:G05850WN.


name: unexplained long-lasting fever/inflammatory syndrome


Rectocele

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A Rectocele results from a tear in the rectovaginal septum (which is normally a tough, fibrous, sheet-like divider between the rectum and vagina). Rectal tissue bulges through this tear and into the vagina as a hernia. There are two main causes of this tear: childbirth, and hysterectomy.


name: tRNA (cytosine(38)-C(5))-methyltransferase isoform E (human)

description: A tRNA (cytosine(38)-C(5))-methyltransferase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14717-5.


A protein that is a translation product of the human TMOD4 gene or a 1:1 ortholog thereof.


tropomodulin-4 isoform h2 (human)

A tropomodulin-4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NZQ9-2.


tropomodulin-4 isoform 1 (human)

A tropomodulin-4 isoform 1 that is encoded in the genome of human.


A steroid acid, the 4-carboxy derivative of zymosterol.


name: Fractured proximal epiphysis of first metacarpal bone

description: A partial or complete breakage of the proximal epiphysis of first metacarpal bone.


yadanziolide T

A quassinoid that is picras-3-ene substituted by hydroxy groups at positions 1, 11, 12, 15 and 21 and oxo groups at positions 2 and 16. Isolated from the ethanol extract of the stem of Brucea mollis, it exhibits cytotoxic activity.


Advanced Extramammary Paget Disease

description: Extramammary Paget disease that has spread extensively to other anatomic sites or is no longer responding to treatment.


scrotum Paget disease

description: A mammary Paget's disease that involves the scrotum.


name: Recurrent Paget Disease of the Anal Canal

description: The reemergence of Paget disease of the anal canal after a period of remission.


Recurrent Extramammary Paget Disease

description: The reemergence of extramammary Paget disease after a period of remission.


Metastatic Extramammary Paget Disease

description: Extramammary Paget disease that has spread from the original site of growth to other anatomic sites.


Paget disease of the penis

description: A premalignant condition morphologically characterized by the presence of the characteristic Paget cells in the intraepithelial tissue of the penis. It presents as a smooth raised reddish area that may or may not be painful. -- 2003


Refractory Extramammary Paget Disease

description: Extramammary Paget disease that is resistant to treatment.


name: DnaJ homolog subfamily A member 1 cysteinylated 2 (human)

description: A DnaJ homolog subfamily A member 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-177 of the amino acid sequence represented by UniProtKB:P31689-1. Example: UniProtKB:P31689-1, Cys-177, MOD:00765.


cullin-4A isoform h2 (human)

A cullin-4A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13619-2.


name: tyrosine-protein kinase SYK cysteinylated 1 (human)

description: A tyrosine-protein kinase SYK (human) that has been cysteinylated on the residue at the position equivalent to Cys-608 of the amino acid sequence represented by UniProtKB:P43405-1. Example: UniProtKB:P43405-1, Cys-608, MOD:00765.


name: tyrosine-protein kinase SYK isoform Short (human)

description: A tyrosine-protein kinase SYK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43405-2.


name: tyrosine-protein kinase SYK deaminated 1 (human)

description: A tyrosine-protein kinase SYK (human) that has been deaminated on the residue at the position equivalent to Asn-499 of the amino acid sequence represented by UniProtKB:P43405-1. Example: UniProtKB:P43405-1, Asn-499, MOD:00684.


name: tyrosine-protein kinase SYK phosphotyrosine form (human)

description: A tyrosine-protein kinase SYK (human) that includes at least one phosphorylated tyrosine. UniProtKB:P43405, MOD:00048.


name: tyrosine-protein kinase SYK phosphorylated 2 (human)

description: A tyrosine-protein kinase SYK phosphorylated 2 in human. UniProtKB:P43405, Tyr-348, MOD:00048.


name: tyrosine-protein kinase SYK phosphorylated 3 (human)

description: A tyrosine-protein kinase SYK (human) that has been post-translationally modified to include phosphotyrosine at positions 131, 323, 348, 352, 525 and 526 of the amino acid sequence represented by UniProtKB:P43405. UniProtKB:P43405, Tyr-131/Tyr-323/Tyr-348/Tyr-352/Tyr-525/Tyr-526, MOD:00048.


name: collagen alpha-1(XXIII) chain 4-hydroxy-proline and galactosylhydroxylysine form (human)

description: A collagen alpha-1(XXIII) chain (human) that includes at least 1 galactosylhydroxylated lysine and at least 3 4-hydroxy-prolines. UniProtKB:Q86Y22, MOD:00039(3+)|MOD:01914.


name: mitogen-activated protein kinase kinase kinase 20 methylated 2 (human)

description: A mitogen-activated protein kinase kinase kinase 20 (human) that has been methylated on the residue at the position equivalent to Arg-670 of the amino acid sequence represented by UniProtKB:Q9NYL2-1. Example: UniProtKB:Q9NYL2-1, Arg-670, MOD:00658.


name: chorion-specific transcription factor GCMa

description: A protein that is a translation product of the human GCM1 gene or a 1:1 ortholog thereof.


name: chorion-specific transcription factor GCMa isoform 1 (human)

description: A chorion-specific transcription factor GCMa isoform 1 that is encoded in the genome of human.


name: chorion-specific transcription factor GCMa isoform 1 acetylated 1 (human)

description: A chorion-specific transcription factor GCMa isoform 1 acetylated 1 in human. UniProtKB:Q9NP62-1, Lys-367/Lys-406/Lys-409, MOD:00064.


name: bromodomain adjacent to zinc finger domain protein 2B deaminated 2 (human)

description: A bromodomain adjacent to zinc finger domain protein 2B (human) that has been deaminated on the residue at the position equivalent to Gln-499 of the amino acid sequence represented by UniProtKB:Q9UIF8-1. Example: UniProtKB:Q9UIF8-1, Gln-499, MOD:00685.


name: bromodomain adjacent to zinc finger domain protein 2B

description: A protein that is a translation product of the human BAZ2B gene or a 1:1 ortholog thereof.


name: bromodomain adjacent to zinc finger domain protein 2B isoform h5 (human)

description: A bromodomain adjacent to zinc finger domain protein 2B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UIF8-5.


name: bromodomain adjacent to zinc finger domain protein 2B isoform h2 (human)

description: A bromodomain adjacent to zinc finger domain protein 2B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UIF8-2.


name: bromodomain adjacent to zinc finger domain protein 2B isoform h4 (human)

description: A bromodomain adjacent to zinc finger domain protein 2B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UIF8-4.


name: bromodomain adjacent to zinc finger domain protein 2B isoform h1 (human)

description: A bromodomain adjacent to zinc finger domain protein 2B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UIF8-1.


name: bromodomain adjacent to zinc finger domain protein 2B isoform h3 (human)

description: A bromodomain adjacent to zinc finger domain protein 2B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UIF8-3.


name: bromodomain adjacent to zinc finger domain protein 2B deaminated 1 (human)

description: A bromodomain adjacent to zinc finger domain protein 2B (human) that has been deaminated on the residue at the position equivalent to Gln-1048 of the amino acid sequence represented by UniProtKB:Q9UIF8-1. Example: UniProtKB:Q9UIF8-1, Gln-1048, MOD:00685.


polycystin-1 isoform h2 (human)

A polycystin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98161-2.


name: alanine aminotransferase 1, initiator methionine removed pyridoxal phosphate lysine 1 (human)

description: An alanine aminotransferase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include pyridoxal phosphate lysine at position 314 of the amino acid sequence represented by UniProtKB:P24298. UniProtKB:P24298, 2-496, Lys-314, MOD:00128.


alanine aminotransferase (human)

An alanine aminotransferase that is encoded in the genome of human.


name: alanine aminotransferase 2 isoform h2 (human)

description: An alanine aminotransferase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TD30-2.


name: alanine aminotransferase 2 isoform h1 pyridoxal phosphate lysine 1 (human)

description: An alanine aminotransferase 2 isoform h1 (human) that has been pyridoxal phosphate lysine on the residue at the position equivalent to Lys-341 of the amino acid sequence represented by UniProtKB:Q8TD30-1. UniProtKB:Q8TD30-1, Lys-341, MOD:00128.


name: alanine aminotransferase 2 phosphorylated 1 (human)

description: An alanine aminotransferase 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-224 of the amino acid sequence represented by UniProtKB:Q8TD30-1. Example: UniProtKB:Q8TD30-1, Ser-224, MOD:00046.


name: alanine aminotransferase 1 isoform 1 (human)

description: An alanine aminotransferase 1 isoform 1 that is encoded in the genome of human.


name: alanine aminotransferase 1, initiator methionine removed acetylated and pyridoxal phosphate lysine 1 (human)

description: An alanine aminotransferase 1, initiator methionine removed acetylated and pyridoxal phosphate lysine 1 in human. UniProtKB:P24298, 2-496, Ala-2, MOD:00050|Lys-314, MOD:00128.


name: alanine aminotransferase 2 isoform h1 (human)

description: An alanine aminotransferase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TD30-1.


name: alpha-N-acetylgalactosaminidase N-glycosylated 102 (human)

description: An alpha-N-acetylgalactosaminidase (human) that has been N-glycosylated at the residue equivalent to Asn-385 of the amino acid sequence represented by UniProtKB:P17050-1, in which the glycan structure is represented by GlyTouCan:G78059CC. Example: UniProtKB:P17050-1, Asn-385, MOD:00160~GNO:G78059CC.


A member of the class of 6-aminopurines that is 2-fluoroadenine carrying additional 2-chloro-3,4,5-trimethoxybenzyl and pent-4-yn-1-yl substituents at positions 8 and 9 respectively.


name: Intracellular accumulation of collagen VII

description: Collagen VII is the major molecular constituent of anchoring fibrils in the skin. Collagen VII is synthesized as three identical pro-alpha1(VII) polypeptide chains, which are hydroxylated and glycosylated in a coordinated manner and then fold into triple-helical procollagen VII in the endoplasmic reticulum (ER). Mature collagen VII undergoes a multistep fibril polymerization process to form the anchoring fibrils. Mutant pro-alpha1(VII) polypeptide chains or procollagen VII molecules do not pass the ER quality control and are retained in the ER or designated for ubiquitin-proteasome degradation resulting in reduced amounts of collagen VII in the skin.


Nonproductive cough

description: A cough that does not produce phlegm or mucus.


Productive cough

description: A cough that produces phlegm or mucus.


name: interferon gamma receptor 1 N-glycosylated 11 (human)

description: An interferon gamma receptor 1 (human) that has been N-glycosylated at the residue equivalent to Asn-79 of the amino acid sequence represented by UniProtKB:P15260-1, in which the glycan structure is represented by GlyTouCan:G53168IY. Example: UniProtKB:P15260-1, Asn-79, MOD:00160~GNO:G53168IY.


name: myeloperoxidase N-glycosylated 8 (human)

description: A myeloperoxidase (human) that has been N-glycosylated at the residue equivalent to Asn-483 of the amino acid sequence represented by UniProtKB:P05164-1, in which the glycan structure is represented by GlyTouCan:G82348BZ. Example: UniProtKB:P05164-1, Asn-483, MOD:00160~GNO:G82348BZ.


Stage II Renal Pelvis Cancer AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Tumor invades muscularis.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Stage II Renal Pelvis and Ureter Cancer AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Tumor invades the muscularis.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Duane retraction syndrome 3 with or without deafness

description: Duane syndrome type 3 is a disorder of eye movement.The affected eye, or eyes, has limited ability to move both inward toward the nose and outward toward the ears. The eye opening narrows and the eyeball pulls in when looking inward toward the nose. About 15 percent of all cases of Duane syndrome are type 3. Most cases occur without other signs and symptoms.In most people with Duane syndrome type 3, the cause is unknown; but it can sometimes be caused by mutations in the CHN1 gene and inherited in an autosomal dominant fashion.


carcinoma in situ of ureter

description: A in situ carcinoma that involves the ureter.


maxillary arteriovenous malformation

description: Maxillary arteriovenous malformation is a rare vascular anomaly characterized by an abnormal connection of the arterial and venous vasculature, without capillary connections, in the maxillofacial area, usually presenting with chronic, intermittent, and potentially life-threatening, hemorrhage. Association with infection, pain, pressure, pulsation, swelling, facial asymmetry, headache, ocular pain, tinnitus, otalgia, epistaxis, toothache and/or teeth mobility and compressibility into their sockets is possible, although it may also be asymptomatic.


ureter inverted papilloma

description: A neoplasm of the ureter in which the epithelial cells grow downward into the underlying supportive tissue, which often causes hematuria.


scirrhous breast carcinoma

description: An infiltrating ductal breast carcinoma associated with stromal fibrosis.


renal pelvis urothelial papilloma

description: A benign neoplasm of the renal pelvis that involves the transitional epithelium projecting above the surrounding epithelial surface and consisting of villous or arborescent outgrowths of fibrovascular stroma.


kidney carcinoma in situ

description: A carcinoma in situ involving a kidney.


adenoid cystic breast carcinoma

description: An adenoid cystic carcinoma primarily involving the breast. Three morphologic patterns are seen: cribriform, trabecular, and solid. The prognosis is excellent.


stage II endometrioid carcinoma

description: Endometrial carcinoma is a carcinoma that arises from the endometrium (the lining of the uterus or womb). It is the result of the abnormal growth of cells that have the ability to invade or spread to other parts of the body. The first sign is most often vaginal bleeding not associated with a menstrual period. Other symptoms include pain with urination or sexual intercourse, or pelvic pain. Endometrial cancer occurs most commonly after menopause. In stage II the cancer has spread from the body of the uterus and is growing into the supporting connective tissue of the cervix (called the cervical stroma). The cancer has spread into connective tissue of the cervix, but has not spread outside the uterus.


nasal cavity carcinoma in situ

description: A in situ carcinoma that involves the nasal cavity.


thyroid gland fetal adenoma

description: A thyroid gland adenoma composed of microfollicular structures.


skin cystic basal cell carcinoma

description: A basal cell carcinoma of the skin that is characterized by cyst formation.


vulvar clear cell hidradenocarcinoma

description: A vulvar sweat gland carcinoma characterized by the presence of clear cells.


stage IVb bladder cancer

description: Stage IV includes T4b, NO,MO/any T NI, MO/ any T N2 MO,/ any T N3 MO/ any T any N M1 : T4b: Tumor invades the pelvic wall, abdominal wall. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. N3: Metastasis in a lymph node more than 5 cm in greatest dimension. M1: Distant metastasis.


name: moderately-differentiated thymic neuroendocrine carcinoma


bladder signet ring cell adenocarcinoma

description: A signet ring cell carcinoma that involves the urinary bladder.


ureter transitional cell carcinoma

description: A carcinoma that arises from the transitional epithelium of the ureter. It is associated with tobacco use and usually presents with gross or microscopic hematuria.


trabecular adenocarcinoma

description: A malignant epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern.


microcystic adenoma

description: A benign epithelial neoplasm characterized by a microcystic pattern. The cystic spaces are lined by small cuboidal cells without evidence of significant cytologic atypia.


name: hereditary clear cell renal cell carcinoma

description: A manifestation of von Hippel-Lindau disease or other familial renal cell cancer syndromes that present as a malignant epithelial neoplasm of the kidney. It is characterized by the presence of lipid-containing clear cells within a vascular network. The tumor usually is bilateral and polycentric, and metastasizes to unusual sites. Late metastasis is common.


basaloid carcinoma of the penis

description: An aggressive, human papillomavirus-related squamous cell carcinoma that arises from the penis. It is characterized by the presence of nests of small malignant cells. The malignant cells tend to invade deeply into the adjacent tissues. Comedo-type necrosis is often present.


Wolffian duct adenocarcinoma

description: A cervical adenocarcinoma that arises from mesonephric remnants. It is usually characterized by the presence of tubular glands lined by cuboidal epithelial cells.


inverted transitional cell papilloma

description: A benign papillary neoplasm composed of transitional cells and characterized by an endophytic growth pattern.


thymic mucoepidermoid carcinoma

description: A rare primary thymic carcinoma, characterized by the presence of squamous cells, intermediate type cells, and mucus-producing cells. Published information on clinical course is limited to single-case reports.


endometrial undifferentiated carcinoma

description: A primary carcinoma of the endometrium characterized by the presence of malignant cells that lack evidence of differentiation.


prostate cancer, hereditary, 2

description: Any familial prostate cancer in which the cause of the disease is a mutation in the ELAC2 gene.


name: female breast lower-outer quadrant cancer


vulvar basaloid squamous cell carcinoma

description: A squamous cell carcinoma that arises from the vulva and is characterized by the presence of nests of malignant basaloid cells with a scant amount of cytoplasm.


endometrial adenosquamous carcinoma

description: A rare endometrial carcinoma characterized by the presence of both malignant glandular and malignant squamous cellular components.


name: thyroid gland atypical follicular adenoma

description: A thyroid gland adenoma with increased cellularity and nuclear atypia. There is no capsular or vascular invasion. The clinical course is benign.


name: oxyphilic endometrial endometrioid adenocarcinoma

description: A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of eosinophilic malignant glandular epithelial cells.


papillary cystic neoplasm

description: A benign, malignant, or borderline neoplasm characterized by the presence of papillary mucinous, serous, or clear cell structures and cystic structures.


ovarian seromucinous carcinoma

description: A malignant mixed epithelial neoplasm that arises from the ovary and is composed predominantly of serous and endocervical-type mucinous epithelium.


testicular Brenner tumor

description: An uncommon usually benign neoplasm that arises from the testis. It is characterized by the presence of cysts lined by transitional cells and solid nests of transitional cells in a spindle cell stroma.


name: endometrial endometrioid adenocarcinoma with spindled epithelial cells

description: A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of spindled malignant epithelial cells.


Bartholin gland adenoma

description: A rare, benign neoplasm that arises from the Bartholin gland and is characterized by the presence of clustered glands and tubules lined by mucin-secreting epithelial cells.


cortical thymoma

description: A thymic epithelial neoplasm characterized by the presence of neoplastic large, polygonal epithelial cells with large vesicular nuclei and prominent nucleoli. The neoplastic cells are arranged around perivascular spaces and along septa. Immature T-lymphocytes are also present. It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. It is a tumor of moderate malignancy. The majority of cases occur in the anterior mediastinum as Masaoka stage I, stage II, or stage III tumors. Metastatic, stage IV tumors occur less frequently.


rete ovarii cystadenoma

description: An exceptionally rare cystadenoma that arises from the rete ovarii.


central breast papilloma

description: A benign papillary neoplasm that arises in a large duct of the breast. It is characterized by the presence of a fibrovascular core that is lined by benign epithelial and myoepithelial proliferations. Patients usually present with nipple discharge.


name: uterine ligament clear cell adenocarcinoma

description: A clear cell adenocarcinoma of the uterine ligament composed mainly of clear or hobnob cells. The clear cells are large, bizarre, and multinucleated.


bone carcinoma

description: A carcinoma that involves the bone element.


microscopic breast papilloma

description: A benign papillary neoplasm that arises in a terminal ductal lobular unit. It is characterized by the presence of a fibrovascular core that is lined by benign epithelial and myoepithelial proliferations. Peripheral breast papillomas are often multiple and are usually found microscopically. Patients are often asymptomatic.


name: endocervical type cervical mucinous adenocarcinoma

description: A cervical mucinous adenocarcinoma characterized by the presence of malignant glandular cells that resemble those of the endocervix.


synchronous bilateral breast carcinoma

description: Carcinoma that is detected in one breast within two months from the diagnosis of carcinoma in the other breast.


lymph node adenoid cystic carcinoma

description: A adenoid cystic carcinoma that involves the lymph node.


name: non-keratinizing sinonasal squamous cell carcinoma

description: A squamous cell carcinoma of the sinonasal tract characterized by a plexiform or ribbon-like growth pattern, cytological atypia, and lack of histological evidence of keratinization.


penis basal cell carcinoma

description: A basal cell carcinoma of the penis with an indolent clinical course. It is usually superficial and arises from the shaft and rarely the glans.


periductal breast myoepitheliosis

description: A neoplastic process characterized by the proliferation of spindle to cuboidal myoepithelial cells around small breast ducts.


name: infiltrating renal pelvis/ureter urothelial carcinoma

description: Invasive urothelial carcinoma that affects the renal pelvis and ureter.


ovarian papillary tumor

description: A benign, borderline, or malignant epithelial tumor that arises from the ovary and is characterized by the presence of papillary proliferations. Representative examples include surface papilloma, borderline serous surface papillary tumor, and serous surface papillary adenocarcinoma.


name: pulmonary type ovarian small cell carcinoma

description: An aggressive small cell neuroendocrine carcinoma that arises from the ovary. Morphologically, it resembles the small cell carcinoma that arises from the lung.


name: ovarian serous surface papillary adenocarcinoma

description: A serous adenocarcinoma that arises from the ovary and is characterized by the presence of a papillary architectural pattern.


epididymal adenocarcinoma

description: A rare adenocarcinoma that arises from the epididymis. It usually presents as a scrotal mass and may be associated with testicular pain.


bladder small cell carcinoma

description: A bladder carcinoma that is characterized as an undifferentiated neoplasm composed of primitive-appearing cells.


vulvar squamous neoplasm

description: A benign, precancerous, or malignant neoplasm that arises from the squamous epithelium of the vulva. Representative examples include vestibular papilloma, intraepithelial neoplasia, and squamous cell carcinoma.


lacrimal gland mucoepidermoid carcinoma

description: An extremely rare carcinoma that arises from the lacrimal gland. It is characterized by the presence of infiltrating nests of epidermoid cells and mucus producing cells.


name: primary intraosseous squamous cell carcinoma

description: A squamous cell carcinoma that arises centrally from the jaw. It derives from odontogenic epithelial remnants. It includes solid type squamous cell carcinoma, squamous cell carcinoma that arises from an odontogenic cyst, and squamous cell carcinoma that derives from a keratocystic odontogenic tumor.


bladder colloid adenocarcinoma

description: A rare primary adenocarcinoma of the bladder. Histologically it is characterized by malignant cells floating in pools of mucin.


name: Bartholin gland transitional cell carcinoma

description: A rare carcinoma that arises from the Bartholin gland and is characterized by the presence of malignant urothelial-type epithelial cells.


endometrial transitional cell carcinoma

description: A rare primary carcinoma of the endometrium characterized by the presence of malignant epithelial cells resembling urothelial transitional cells. The malignant transitional cells constitute at least 90% of the tumor cells.


vulvar keratoacanthoma-like carcinoma

description: A rapidly growing squamous cell carcinoma that arises from the vulva. It is self-limited and is characterized by the presence of a central crater that contains squamous cells. The proliferating squamous cells infiltrate the dermis below and produce keratin masses that are pushed towards the surface of the tumor.


mucinous ovarian cystadenoma

description: A benign neoplasm of the ovary characterized by the presence of cystic structures lined by mucinous columnar epithelial cells.


vaginal squamous tumor

description: A benign or malignant neoplasm that arises from the squamous epithelium of the vagina. Representative examples include condyloma acuminatum, squamous papilloma, and squamous cell carcinoma.


seminal vesicle adenocarcinoma

description: A carcinoma that arises from glandular epithelial cells of the seminal vesicle


papilloma of eyelid

description: A papilloma that involves the eyelid.


vulvar sebaceous carcinoma

description: A carcinoma that arises from the vulva. It is characterized by the presence of malignant basaloid glandular epithelial cells that resemble sebaceous epithelium and are arranged in cords and nests.


verrucous hemangioma

description: A skin hemangioma characterized by the presence of epidermal hyperplasia.


name: mucin-rich endometrial endometrioid adenocarcinoma


salivary gland acinic cell carcinoma

description: A carcinoma of the salivary gland characterized by serous acinar cell differentiation. The vast majority of cases occur in the parotid gland. It usually presents as a slowly enlarging mass. A minority of patients experience pain. It may recur or metastasize. Multiple recurrences and metastasis to cervical lymph nodes are usually associated with a poor prognosis.


lacrimal gland adenocarcinoma

description: A carcinoma that arises from glandular epithelial cells of the lacrimal gland


Wyburn-Mason syndrome

description: Wyburn-Mason syndrome or Bonnet-Dechaume-Blanc syndrome is characterized by the association of arteriovenous malformations of the maxilla, retina, optic nerve, thalamus, hypothalamus and cerebral cortex.


mucinous cystadenofibroma

description: A benign neoplasm characterized by the presence of cystic structures lined by mucinous columnar epithelial cells in a fibrotic stroma.


familial parathyroid adenoma

description: An instance of parathyroid gland adenoma that is caused by an inherited modification of the individual's genome.


scirrhous adenocarcinoma

description: An infiltrating adenocarcinoma characterized by the presence of desmoplastic stromal reaction.


bone ameloblastoma

description: A ameloblastoma that involves the bone tissue.


breast apocrine carcinoma in situ

description: A ductal breast carcinoma in situ, characterized by the presence of neoplastic epithelial cells with apocrine differentiation.


name: pituitary gland mixed eosinophil-basophil adenoma

description: An epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic and basic dyes.


name: nasal cavity and paranasal sinus squamous cell carcinoma

description: A rare, keratinizing or non-keratinizing squamous cell carcinoma arising from the mucosal epithelium of the nasal cavity or the paranasal sinuses. It affects most often the maxillary sinus. Less frequently, it arises from the nasal cavity, ethmoid sinus, sphenoid sinus, and frontal sinus. Symptoms include nasal fullness, epistaxis, rhinorhea, pain, and paresthesia. Patients with nasal squamous cell carcinoma usually present earlier than patients with maxillary sinus carcinoma and have a better prognosis compared to the latter group.


warty dyskeratoma

description: A rare, usually solitary, benign epithelial tumor of the skin that appears to arise from a hair follicle. It usually develops in the head and neck region as a nodular lesion with a central keratotic plug.


name: infiltrating ureter transitional cell carcinoma


benign epithelial skin neoplasm

description: A form of epithelial skin neoplasm without malignant characteristics.


cystic, mucinous, and serous neoplasm

description: Neoplasms containing cyst-like formations or producing mucin or serum.


name: partially involuting congenital hemangioma

description: A clinical subtype of congenital hemangioma that begins as a rapidly involuting congenital hemangioma (RICH) but fails to completely involute and persists as a non-involuting congenital hemangioma (NICH)-like lesion


name: large cell keratinizing variant squamous cell breast carcinoma

description: A squamous cell carcinoma that arises from the breast parenchyma and is characterized by the presence of large malignant cells that exhibit keratinization.


clear cell papillary cystadenoma

description: A benign cystic glandular epithelial neoplasm characterized by the presence of neoplastic clear or hobnail cells which form papillary structures. There is no evidence of stromal invasion.


uterus carcinoma in situ

description: A carcinoma in situ involving a uterus.


sphenoidal sinus cancer

description: A malignant neoplasm involving the sphenoidal sinus.


bladder papillary urothelial neoplasm

description: A papillary epithelial neoplasm that involves the urinary bladder urothelium.


external ear squamous cell carcinoma

description: A squamous cell carcinoma that arises from the skin of the external ear.


prostate cancer, hereditary, 13

description: Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene.


spindle cell hemangioma

description: Spindle cell hemangioma (SCH), also known as spindle cell hemangioendothelioma, is a rare benign vascular tumor either solitary or multiple, characterized by cavernous blood vessels separated by spindle cells reminiscent of those in KaposiBs sarcoma and located in the dermis and subcutis.


breast myoepithelial tumor

description: A benign or malignant tumor that arises from the breast and originates from or is composed of myoepithelial cells. Representative examples include adenomyoepithelioma, myoepitheliosis, and malignant myoepithelioma.


breast ductal adenoma

description: A benign, well circumscribed neoplasm that is located within the lumen of a duct in the breast parenchyma. It is characterized by the presence of glandular structures at the periphery and fibrous tissue at the center of the tumor.


breast malignant eccrine spiradenoma

description: A rare tumor characterized by malignant transformation of an eccrine spiradenoma of the breast.


Bartholin gland adenosquamous carcinoma

description: A carcinoma that arises from the Bartholin gland and is characterized by the presence of malignant glandular epithelial cells and malignant squamous epithelial cells.


name: osteosarcoma arising in bone Paget disease

description: A sarcomatous transformation of pre-existing Paget disease of the bone. Osteosarcomas arising from Paget disease of the bone are high grade lesions and usually have a poor prognosis.


rete ovarii adenocarcinoma

description: An exceptionally rare adenocarcinoma that arises from the rete ovarii.


ovarian clear cell tumor

description: A benign, borderline, or malignant epithelial tumor of the ovary that is characterized by a predominance of clear and hobnail cells.


thyroid gland macrofollicular adenoma

description: A thyroid gland adenoma composed of large size follicles.


non-involuting congenital hemangioma

description: Non-involuting congenital hemangioma (NICH) is a rare type of infantile hemangioma, which is a tumor that forms from the abnormal growth of blood vessels in the skin. NICH looks like an oval,purplish mark or bump that can occur on any part of the body. NICH is present from birth (congenital) and increases in size as the child grows. Unlike other hemangiomas, NICH do not disappear spontaneously (involute).


ceruminous carcinoma

description: An infiltrating adenocarcinoma derived from ceruminous glands in the external auditory canal.


noninvasive malignant thymoma

description: A morphologically malignant thymoma that is entirely confined within the capsule.


benign mesonephroma

description: A benign epithelial neoplasm of the female reproductive system arising from mesonephric remnants.


name: non-invasive verrucous carcinoma of the penis


urothelial papilloma

description: A rare benign condition, characterized by a papillary growth in the urinary tract with a central fibrovascular core. The latter is lined by normal urothelium.


name: adenoid cystic carcinoma of the corpus uteri

description: A adenoid cystic carcinoma that involves the body of uterus.


plantar verrucous skin carcinoma

description: A verrucous carcinoma that involves the plantar part of pes.


benign basal cell neoplasm

description: A neoplasm composed of basal cells that remains localized and does not metastasize to other anatomic sites.


breast epithelioid hemangioma

description: A hemangioma characterized by the presence of epithelioid endothelial cells, arising from the breast.


name: paranasal sinus adenoid cystic carcinoma

description: A rare adenoid cystic carcinoma that arises from the paranasal sinuses. It usually has an aggressive clinical course characterized by high recurrence rates and distant metastases.


breast mucinous cystadenocarcinoma

description: An invasive breast adenocarcinoma characterized by the presence of tall columnar neoplastic cells that contain intracytoplasmic mucin. Grossly, cystic changes are identified.


carcinoma of Cowper glands

description: A carcinoma that involves the bulbo-urethral gland.


name: non-invasive bladder urothelial carcinoma

description: Stage 0 includes: 0a (Ta, N0, M0); 0is (Tis, N0, M0). Ta: Noninvasive papillary carcinoma. Tis: Carcinoma in situ: "flat tumor". N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: breast large cell neuroendocrine carcinoma

description: A poorly differentiated neuroendocrine carcinoma that arises from the breast. It is characterized by the presence of large neuroendocrine cells and high mitotic activity.


chromophil adenoma of the kidney

description: A controversial term, used for renal papillary lesions which measure 1cm or less in diameter and contain small, regular nuclei.


clear cell squamous cell skin carcinoma

description: A squamous cell carcinoma of the skin with a prominent clear cell component.


sclerosing breast papilloma

description: A breast papilloma characterized by the presence of predominant sclerosing architectural features.


labia majora carcinoma

description: A carcinoma that arises from the labia majora.


frontal sinus Schneiderian papilloma

description: A papilloma that arises from the ciliated respiratory mucosa that lines the frontal sinus. It is classified as inverted papilloma and oncocytic papilloma.


retroperitoneum carcinoma

description: A carcinoma that arises from epithelial cells of the retroperitoneal space.


papilloma of buccal mucosa

description: A papilloma that involves the buccal mucosa.


cavernous hemangioma of orbit

description: A cavernous hemangioma arising from the orbit.


endometrial small cell carcinoma

description: A primary carcinoma of the endometrium that is similar to the small cell carcinoma of the lung, histologically.


ovarian adenoma benign

description: A benign adenoma of ovary


skin epithelioid hemangioma

description: A hemangioma arising from the skin. It is characterized by the presence of epithelioid endothelial cells.


familial keratoacanthoma

description: Multiple familial keratoacanthoma (KA) of Witten and Zak is a rare a rare inherited skin cancer syndrome and is characterized by the coexistence of features characteristic of both multiple KA, Ferguson Smith type and generalized eruptive keratoacanthoma, such as multiple small miliary-type lesions, larger self-healing lesions, and nodulo-ulcerative lesions. Lesions do not have a predilection for the mucosal surfaces. Transmission is autosomal dominant.


tubulovillous adenoma

description: An epithelial neoplasm morphologically characterized by the presence of a villous and a tubular architectural pattern. Most often it occurs in the large intestine, small intestine, and the stomach in which the neoplastic epithelial cells show dysplastic features.


name: cervical keratinizing squamous cell carcinoma

description: A variant of cervical squamous cell carcinoma characterized by the presence of keratin pearls. Intercellular bridges and cytoplasmic keratinization are usually present.


thymic undifferentiated carcinoma

description: A rare primary thymic carcinoma, characterized by an undifferentiated solid tumor growth, without associated sarcomatoid features.


signet ring basal cell carcinoma

description: A rare type of basal cell carcinoma. It is characterized by the presence of mucin containing signet ring cells.


renal pelvis papillary tumor

description: A papillary tumor originating in the renal pelvis.


ovarian Brenner tumor

description: A benign, borderline, or malignant transitional cell neoplasm arising from the ovary. It constitutes between 1% and 2% of all ovarian neoplasms. The average age at presentation is about 50 years. Grossly it is usually unilateral, firm and white or yellowish. Microscopically it consists of solid and cystic nests of epithelial cells resembling transitional epithelium surrounded by an abundant stromal component of dense, fibroblastic nature.


name: squamous cell carcinoma of the corpus uteri

description: A squamous cell carcinoma that involves the body of uterus.


name: childhood renal cell carcinoma with MiT translocations

description: A renal cell carcinoma with MiT translocations that is characterized by a TFE3 or TFEB-rearranged renal cell carcinoma that occurs during childhood.


ovarian mucinous cystadenofibroma

description: A benign neoplasm of the ovary characterized by the presence of cystic structures lined by mucinous columnar epithelial cells in a fibrotic stroma.


name: cortisol-producing adrenal cortex adenoma

description: An adenoma of the adrenal cortex that produces cortisol. It may be associated with Cushing syndrome. Clinical presentation includes weight gain, round face, easy bruising, muscle weakness, emotional changes, hirsutism, and hypertension.


eyelid capillary hemangioma

description: A capillary hemangioma arising from the eyelid.


adrenocortical carcinoma, hereditary

description: An instance of adrenal cortex carcinoma that is caused by an inherited modification of the individual's genome.


vaginal squamous papilloma

description: A benign papillary neoplasm that arises from the vagina and is characterized by the presence of a fibrovascular stalk lined by normal squamous epithelium. There is no evidence of atypia or relation to human papillomavirus.


fallopian tube squamous cell carcinoma

description: A rare squamous cell carcinoma that arises from the fallopian tube.


name: sarcomatoid penile squamous cell carcinoma

description: A squamous cell carcinoma that arises from the penis and is characterized by the presence of malignant spindle-shaped cells.


PAX6-related ocular dysgenesis

description: Any eye disorder in which the cause of the disease is a mutation in the PAX6 gene.


lymphangioendothelioma

description: A lymphangioma characterized by the presence of collagen bundle formation. It has an indolent clinical course and may be associated with skin plaques.


name: acquired cystic disease-associated renal cell carcinoma

description: Acquired cystic disease-associated renal cell carcinoma is a rare subtype of renal cell carcinoma, occurring in the context of end-stage kidney disease and acquired cystic kidney disease, characterized by a usually well circumscribed, solid, multifocal, bilateral tumor with inter- or intracellular microlumen formation (leading to cribiform architecture). Tumors are often diagnosed incidentally in early stages, although complications caused by renal cysts (dull flank or abdominal pain, fever) or renal parenchymal bleeding may mask the underlying neoplastic process. Most have an indolent behavior.


name: Bartholin gland adenoid cystic carcinoma

description: A carcinoma that arises from the Bartholin gland and is characterized by the presence of islands of uniform malignant cells forming cribriform patterns.


malignant ovarian serous tumor

description: An invasive malignant neoplasm that arises from the ovary and is characterized by the presence of malignant epithelial cells that, in well differentiated tumors, resemble the epithelium of the fallopian tube or, in poorly differentiated tumors, show anaplastic features and marked nuclear atypia. It includes serous adenocarcinoma and serous adenocarcinofibroma.


name: well-differentiated thymic neuroendocrine carcinoma


benign breast adenomyoepithelioma

description: A benign, nodular tumor that arises from the breast parenchyma. It is characterized by the proliferation of myoepithelial cells around spaces that are lined by epithelial cells. Occasionally, adenomyoepitheliomas may undergo malignant transformation.


intraductal breast myoepitheliosis

description: A neoplastic process characterized by the proliferation of spindle to cuboidal myoepithelial cells within small breast ducts.


mandibular arteriovenous malformation

description: Mandibular arteriovenous malformation is a rare vascular anomaly characterized by an abnormal connection of the arterial and venous vasculature, without capillary connections, in the mandibular area, commonly presenting with minor gingival bleeding, dental loosening, lower lip numbness, facial deformity and malocclusion. This usually high-flow vascular malformation may also present with potentially life-threatening, spontaneous, or tooth extraction-induced, hemorrhagic shock.


glomeruloid hemangioma

description: A hemangioma associated with Castleman disease and POEMS syndrome. The lesions affect the trunk and extremities and present as erythematous papules. (WHO 2018)


name: arteriovenous malformations of the brain

description: Cerebral arteriovenous malformation (AVM) is a congenital malformative communication between the veins and the arteries in the brain in the form of a nidus, an anatomical structure composed of dilated and tangled supplying arterioles and drainage veins with no intervening capillary bed, that can be asymptomatic or cause, depending on the location and the size of the AVM, headaches of varying severity, generalized or focal seizures, focalneurological defects (weakness, numbness, speech difficulties, vision loss) or potentially fatal intracranial hemorrhage in case the AVM ruptures.


name: fallopian tube clear cell adenocarcinoma

description: A rare adenocarcinoma of the fallopian tube composed of malignant glandular epithelium containing clear cells.


name: bladder diffuse clear cell adenocarcinoma

description: A rare morphologic variant of bladder adenocarcinoma characterized by the presence of malignant glandular epithelial cells and clear cells forming a diffuse pattern.


water-clear cell adenoma

description: A rare parathyroid gland adenoma composed of neoplastic cells with abundant cytoplasm. The cytoplasm of the neoplastic cells is usually not entirely clear, and is often variably vacuolated, foamy, and granular.


juvenile breast papillomatosis

description: A benign, usually solitary, well circumscribed multicystic neoplasm that arises from the breast and typically affects young females. The cysts are lined by papillary proliferations that contain epithelial and myoepithelial layers. In a minority of cases, atypia may be present.


cervical serous adenocarcinoma

description: A rare adenocarcinoma that arises from the cervix. It is characterized by the presence of papillary patterns and cellular budding. Psammoma bodies are often seen.


pituitary gland basophil adenoma

description: An epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with basic dyes.


renal pelvis inverted papilloma

description: A neoplasm of the renal pelvis in which the epithelial cells grow downward into the underlying supportive tissue.


vaginal adenoid cystic carcinoma

description: An adenoid cystic carcinoma that arises from the vagina. Myoepithelial cells are usually not present.


metatypical basal cell carcinoma

description: A skin carcinoma displaying cytological characteristics intermediate to nodular basal cell carcinoma and squamous cell carcinoma.


eye carcinoma in situ

description: A carcinoma in situ involving a eye.


ovarian surface papilloma

description: A benign serous neoplasm characterized by the presence of papillary proliferations on the surface of the ovary.


skin basaloid carcinoma

description: A basaloid squamous cell carcinoma that involves the zone of skin.


vulvar eccrine adenocarcinoma

description: An eccrine adenocarcinoma that arises from the sweat glands in the vulva.


skin adenoid basal cell carcinoma

description: A variant of basal cell carcinoma morphologically characterized by the presence of thin strands of basaloid cells forming a reticulate pattern.


name: female breast lower-inner quadrant cancer


capillary lymphangioma

description: A lymphangioma that involves the capillary.


cervical mullerian papilloma

description: A rare, benign, papillary neoplasm that arises from the cervix. It is characterized by the presence of a fibrovascular core covered by mucinous epithelial cells.


bladder urachal adenocarcinoma

description: A adenocarcinoma that involves the urachus.


acquired hemangioma

description: A hemangioma that is not present at birth but develops later in life.


desmoplastic ameloblastoma

description: An ameloblastoma with prominent desmoplastic stroma that causes compression of the neoplastic epithelial islands.


infundibulocystic basal cell carcinoma

description: A rare type of basal cell carcinoma. It is characterized by multiple tiny cysts lined by infundibular epithelium.


name: carcinoma arising in nasal papillomatosis

description: A rare squamous cell carcinoma that either arises from or is associated with the presence of inverted papilloma in the nose.


lacrimal gland squamous cell carcinoma

description: A squamous cell carcinoma that involves the lacrimal gland.


carcinoma in situ of renal pelvis

description: A in situ carcinoma that involves the renal pelvis.


name: villoglandular endometrial endometrioid adenocarcinoma

description: A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of numerous finger-like villi lined by neoplastic columnar cells.


ureter urothelial papilloma

description: A benign epithelial neoplasm that produces visible warty projections from the epithelial surface of the ureter.


epithelial skin neoplasm

description: A epithelial neoplasm that involves the zone of skin.


renal pelvis adenocarcinoma

description: A carcinoma that arises from glandular epithelial cells of the renal pelvis


name: superficial multifocal basal cell carcinoma

description: A superficial basal cell carcinoma of the skin characterized by the presence of lobules of basaloid cells which are separated by large distances and represent multifocal discrete tumors.


mucin-producing carcinoma

description: An invasive adenocarcinoma composed of malignant glandular cells which produce mucin.


intra-abdominal hemangioma

description: A hemangioma arising from organs within the abdominal cavity.


skin hemangioma

description: A hemangioma arising from the skin.


bladder urothelial papilloma

description: A benign neoplasm of the bladder that involves the transitional epithelium projecting above the surrounding epithelial surface and consisting of villous or arborescent outgrowths of fibrovascular stroma.


name: acantholytic variant squamous cell breast carcinoma

description: A squamous cell carcinoma that arises from the breast parenchyma and is characterized by cellular discohesion resulting in a pseudoangiosarcomatous pattern.


malignant hemangioma

description: A malignant form of hemangioma.


intraductal papillomatosis

description: A neoplastic process characterized by the presence of multiple intraductal papillomas.


parathyroid gland clear cell adenoma

description: A parathyroid gland adenoma composed predominantly of neoplastic cells with clear cytoplasm.


ovarian endometrioid cystadenoma

description: A benign neoplasm of the ovary characterized by the presence of cystic structures lined by endometrial-type well-differentiated cells.


vaginal mullerian papilloma

description: A benign papilloma that arises from the vagina in infants and young women.


name: lacrimal gland carcinoma ex pleomorphic adenoma

description: A carcinoma arising in a pre-existing pleomorphic adenoma in the lacrimal gland.


name: pseudovascular skin squamous cell carcinoma

description: A squamous cell carcinoma of the skin histologically resembling a vascular tumor due to extreme acantholysis.


frontal sinus inverted papilloma

description: A benign neoplasm that arises from the ciliated respiratory mucosa that lines the frontal sinus. It results from the invagination and proliferation of epithelial cells in the underlying stroma.


malignant type AB thymoma

description: A type AB thymoma which is characterized by an aggressive clinical course (capsular invasion, infiltration of the surrounding tissues) and can metastasize.


cutaneous mucoepidermoid carcinoma

description: A mucoepidermoid carcinoma that involves the zone of skin.


comedocarcinoma

description: A high grade carcinoma characterized by the presence of comedo-type of tumor cell necrosis in which the necrotic areas are surrounded by a solid proliferation of malignant pleomorphic cells.


brain stem hemangioblastoma

description: A hemangioblastoma that involves the brainstem.


name: acantholytic squamous cell skin carcinoma

description: A histologic variant of squamous cell carcinoma that arises from the skin. It is characterized by loosening of the intercellular bridges between the malignant cells which results in acantholysis.


hemangioma of orbit

description: A hemangioma arising from the orbit.


cherry hemangioma

description: A capillary hemangioma of the skin, presenting as a red papular lesion.


name: non-invasive bladder papillary urothelial neoplasm

description: A papillary neoplasm of the urinary bladder in which the transitional cells form papillae. The papillary structures exhibit minimal architectural distortion and minimal atypia. Mitoses are infrequent. Patients are at an increased risk of developing new papillary lesions. Occasionally, the new lesions are urothelial carcinomas.


mucinous adenofibroma

description: A benign adenofibroma characterized by the presence of epithelial cells which contain intracytoplasmic mucin and a fibrotic stroma. A representative example is the ovarian mucinous adenofibroma. Cases with epithelial atypia described in the ovary lacking stromal invasion are designated as borderline mucinous adenofibromas and have a low grade malignant potential.


cervix squamous papilloma

description: A papilloma that arises from the squamous epithelium of the cervix.


bladder urachal urothelial carcinoma

description: A transitional cell carcinoma of the urinary bladder that arises from the urachal epithelium.


adenosquamous breast carcinoma

description: An invasive breast carcinoma characterized by the presence of tubular and glandular neoplastic cell structures, admixed with islands of neoplastic cells showing squamous differentiation.


bladder hepatoid adenocarcinoma

description: A hepatoid adenocarcinoma that involves the urinary bladder.


penis verrucous carcinoma

description: A slow growing, locally recurring, very well differentiated papillary squamous cell carcinoma that arises from the penis. It is characterized by the presence of acanthosis and hyperkeratosis. The neoplastic infiltrate extends into the underlying stroma with a pushing border. Koilocytotic atypia is not present.


name: female breast upper-inner quadrant cancer


name: thyroid carcinoma, nonmedullary, with or without cell oxyphilia


metastatic carcinoma in the bone

description: A carcinoma that has spread to the bone from another, primary anatomic site. Bone is one of the most frequent sites of metastatic carcinoma. Common sites of origin include lung, breast, and prostate.


name: fallopian tube transitional cell carcinoma

description: A rare transitional cell carcinoma that arises from the fallopian tube.


foveal hypoplasia 1

description: Any foveal hypoplasia in which the cause of the disease is a mutation in the PAX6 gene.


name: primary peritoneal serous adenocarcinoma

description: A rare, serous adenocarcinoma that diffusely involves the pelvic peritoneum seen predominantly in elderly postmenopausal women. Exclusion of serous carcinoma arising from the ovary and fimbrial end of fallopian tube is required to diagnose the above entity.


benign ovarian mucinous tumor

description: A non-metastasizing neoplasm that arises from the ovary and is characterized by the presence of neoplastic epithelium that resembles the epithelium of the endocervix or gastrointestinal tract. It includes mucinous adenofibroma, mucinous cystadenofibroma, and mucinous cystadenoma.


chest wall parachordoma

description: A parachordoma arising from the chest wall.


oncocytic breast carcinoma

description: A rare breast adenocarcinoma characterized by the presence of neoplastic oncocytic cells. The oncocytic cells comprise more than 70 percent of the malignant cellular population.


sympathetic paraganglioma

description: A benign or malignant paraganglioma arising from the chromaffin cells of the paraganglia that are located along the sympathetic nerves. It includes extra-adrenal paragangliomas and paragangliomas that arise from the adrenal medulla. The latter are commonly referred to as pheochromocytomas. Representative examples of extra-adrenal sympathetic paragangliomas include the bladder, and superior and inferior paraaortic paragangliomas. Clinical signs are related to the secretion of catecholamines resulting in hypertension.


middle ear adenocarcinoma

description: A carcinoma that arises from glandular epithelial cells of the middle ear


benign epithelial neoplasm

description: A neoplasm arising from the epithelial cells. It is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign epithelial neoplasms remain confined to the original site of growth and only rarely metastasize to other anatomic sites.


perineural angioma

description: A hemangioma arising from perineural tissues.


bladder papillary urothelial carcinoma

description: An invasive or non-invasive papillary transitional cell carcinoma of the urinary bladder. It is classified as low - or high-grade. -- 2003


name: sarcomatoid squamous cell skin carcinoma

description: A squamous cell carcinoma of the skin with a prominent spindle cell component.


thymoma, familial

description: An instance of thymoma (disease) that is caused by an inherited modification of the individual's genome.


placental hemangioma

description: A hemangioma arising from the fetal blood vessels in the placental villi.


plexiform ameloblastoma

description: A histologic variant of solid/multicystic ameloblastoma characterized by the presence of basal cells forming anastomosing strands and cords in a delicate stroma.


name: angioma serpiginosum, autosomal dominant


eccrine papillary adenoma

description: A benign neoplasm arising from the sweat glands. It is characterized by the presence of eccrine ducts in the dermis containing intraluminal papillary projections.


name: transitional cell carcinoma of the corpus uteri

description: A transitional cell carcinoma that involves the body of uterus.


angioma serpiginosum

description: Angioma serpiginosum (AS) is a benign congenital skin disease characterized by progressive dilation of the subepidermal skin vessels manifesting as purple punctate lesions usually appearing on the lower limbs and buttocks and following the lines of Blaschko.


endometrium carcinoma in situ

description: A carcinoma in situ involving a endometrium.


thyroid cancer, nonmedullary, 5

description: Any thyroid cancer, nonmedullary in which the cause of the disease is a mutation in the HABP2 gene.


ovarian mucinous adenofibroma

description: A benign neoplasm of the ovary characterized by the presence of glands with mucinous columnar epithelial cells in a fibrotic stroma.


nasal cavity carcinoma

description: A carcinoma that arises from epithelial cells of the nasal cavity


frontonasal arteriovenous malformation

description: Frontonasal arteriovenous malformation is a rare vascular anomaly characterized by abnormal communication between arteries and veins, bypassing the capillary bed, located in the frontonasal area. It may present with intermittent nasal bleeding, blurred vision, pustule formation and/or disfigurement. Overlying skin may be of normal appearance or may manifest a red, pulsatile mass with local rise of temperature. Other features may include pain, ulceration, excessive growth and/or congestive heart failure.


combined carcinoid and adenocarcinoma

description: A malignant epithelial neoplasm composed of a mixture of neuroendocrine cells with morphologic and immunohistochemical characteristics of carcinoid tumor and malignant glandular cells.


papillary eccrine carcinoma

description: A carcinoma of the eccrine glands. It consists of dilated ducts with papillary projections.


papillary thymic adenocarcinoma

description: A rare primary thymic adenocarcinoma, characterized by a papillary growth pattern. There are only a few published cases, and no good data regarding prognosis.


angiokeratoma of mibelli

description: A type of angiokeratoma that typically presents in women on the dorsa of fingers and toes and multiple dark red papules with a slightly verrucous surface, each measuring about 3-5 mm in diameter.


pseudoglandular squamous cell carcinoma

description: A squamous cell carcinoma characterized by the formation of gland-like structures.


breast capillary hemangioma

description: A capillary hemangioma arising from the breast.


name: low grade vulvar intraepithelial neoplasia

description: An intraepithelial lesion of the vulvar squamous epithelium that represents the clinical and morphological manifestation of a productive HPV infection. Low grade refers to the associated low risk of concurrent or future cancer. (WHO, 2014)


trachea carcinoma in situ

description: A carcinoma that arises from the tracheal mucosa and is confined to the epithelial layer without evidence of further tissue invasion.


clear cell hidradenoma

description: An uncommon benign neoplasm of the sweat glands characterized by the presence of clear cells.


thymoma type B

description: An epithelial neoplasm arising from the thymus. It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. It includes thymoma type B1 which is a thymoma of low grade malignant potential, thymoma type B2 which is a thymoma of moderate malignancy, and thymoma type B3 which is also known as well differentiated thymic carcinoma.


maxillary sinus Schneiderian papilloma

description: A papilloma that arises from the ciliated respiratory mucosa that lines the maxillary sinus. It is classified as inverted papilloma and oncocytic papilloma.


name: fallopian tube gestational choriocarcinoma

description: A malignant trophoblastic tumor that arises from the fallopian tube during pregnancy.


mixed cell adenoma

description: An adenoma characterized by the presence of a mixed epithelial cell population.


prostate cancer, hereditary, 12

description: Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene.


name: microinvasive cervical squamous cell carcinoma

description: A cervical squamous cell carcinoma with minimal stromal invasion. The risk of lymph node metastasis is low.


hemangioma of peripheral nerve

description: A hemangioma arising from the peripheral nerves.


thyroid cancer, nonmedullary, 4

description: Any thyroid cancer, nonmedullary in which the cause of the disease is a mutation in the FOXE1 gene.


vulvar trichoepithelioma

description: A benign neoplasm that arises from the vulva and is characterized by the presence of nests of monomorphic basaloid cells forming small cysts that contain keratin.


fallopian tube serous adenocarcinoma

description: A serous adenocarcinoma that arises from the fallopian tube. It is usually a high grade invasive adenocarcinoma.


synovial angioma

description: A rare hemangioma arising from synovium lining surfaces.


bladder urachal carcinoma

description: Urachal cancer is a type of bladder cancer, making up less than 1% of all bladder cancers. The urachus is a structure normally only present during development in the womb that connects the bellybutton and the bladder. This connection normally disappears before birth, but in some people remains. Urachalcancers are usually diagnosed in adults in their 50's and 60's and may develop at the dome or anterior wall of the bladder, along the midline of the body (including the belly button), and between the pubis symphasis and the bladder.Most urachal cancersare adenocarcinomas (cancers that develop from gland cells).Others may besarcomas (which develop from connective tissue -such as leiomyosarcoma, rhabdomyosarcoma, and malignant fibrous histiocytoma), small cell carcinomas, transitional cell cancer, and mixed neoplasias. Most individuals with urachal cancer have symptoms of with hematuria (blood in urine). Other symptoms may include abdominal pain, a palpable abdominal mass, mucinuria, and bacteriuria. Treatment usually involved surgery to remove the cancer.


parachordoma

description: A rare, usually benign myoepithelial tumor characterized by the presence of epithelioid, often vacuolated neoplastic cells. Most patients present with painless swelling in the subcutaneous or subfascial soft tissues of the extremities.


name: intraductal cribriform breast adenocarcinoma

description: A ductal carcinoma in situ of the breast characterized by the presence of a cribriform architectural pattern.


name: SMARCB1-deficient kidney medullary carcinoma

description: A high-grade carcinoma that arises from the renal medulla and is characterized by inactivation of the SMARCB1 gene. It affects children and adults and occurs mainly in patients with sickle cell trait. The majority of the cases occur in the right kidney.


clitoral carcinoma

description: A carcinoma that arises from the clitoris.


trachea mucoepidermoid carcinoma

description: A mucoepidermoid carcinoma that involves the trachea.


hereditary fallopian tube carcinoma

description: Fallopian tube carcinoma that has developed in relatives of patients that have a history of fallopian tube carcinoma.


vaginal villous adenoma

description: An adenoma that arises from the vagina and is characterized by a villous architectural pattern.


name: familial papillary thyroid carcinoma with renal papillary neoplasia

description: Familial papillary thyroid carcinoma with renal papillary neoplasia (fPTC/PRN) is an extremely rare inherited tumor syndrome within the familial nonmedullary thyroid cancer group (fNMTC).


prostate adenoid cystic carcinoma

description: An adenoid cystic carcinoma that arises from the prostate gland.


Bartholin gland adenocarcinoma

description: A carcinoma that arises from glandular epithelial cells of the major vestibular gland.


Krukenberg carcinoma

description: Metastatic signet-ring cell carcinoma to the ovary. The primary site is the gastrointestinal tract or breast.


digital papillary eccrine carcinoma

description: An adenocarcinoma arising from the sweat glands. Most cases present as nodular lesions on the digits, usually in the hands. It is characterized by the presence of epithelial cells in the dermis forming nodules. Cystic structures containing papillary projections are also present. It may recur and metastasize, most commonly to the lungs.


breast columnar cell mucinous carcinoma

description: An invasive breast adenocarcinoma characterized by the presence of tall columnar neoplastic cells that contain intracytoplasmic mucin. Grossly, cystic changes are not identified.


vein of Galen aneurysm

description: Vein of Galen aneurysm is a rare formof arteriovenous malformation in which the embryonic precursor to the vein of Galen, a vein at the base of the brain, dilates causing too much blood to rush to the heart. This can lead to rapid heart failure. Other features may include increased head circumference resulting from hydrocephalus, unusually prominent veins on the face and scalp, developmental delay, persistent headache, and other neurological findings. Vein of Galen aneurysm is often recognized on an ultrasound late in pregnancy. In other cases, it is diagnosed after birth. Although the exact cause remains unknown, this condition appears to result from a defect in early fetal development. Treatment is aimed at decreasing the blood flow through the malformation while maximizing the blood supply to the brain. Minimally invasive surgical techniques are preferred, such as endovascular embolization.


inverted papilloma

description: An endophytic benign papillary epithelial neoplasm that results from the invagination and proliferation of epithelial cells in the underlying stroma. Representative examples are the inverted urothelial papilloma that arises from the urinary tract and inverted Schneiderian papilloma that arises from the nasal cavity or paranasal sinuses.


pilar sheath acanthoma

description: A benign, small, papular or nodular skin neoplasm that usually arises above the upper lip. It is characterized by an epithelial proliferation with a central cavity. The cavity wall is lined with keratinocytes.


name: sex hormone-producing adrenal cortex adenoma

description: A rare adenoma of the adrenal cortex that produces androgens or estrogens.


malignant breast myoepithelioma

description: An invasive malignant tumor that arises from the breast. It is characterized by the presence of spindle-shaped myoepithelial cells. Mitoses are present. Rarely, local recurrences and distant metastases have been reported.


type 1 papillary adenoma of the kidney

description: A renal papillary adenoma which is characterized by basophilic cells with scant amount of cytoplasm.


endometrial mucinous adenocarcinoma

description: A primary, usually low grade adenocarcinoma of the endometrium in which the majority of the malignant epithelial cells contain abundant intracytoplasmic mucin.


stage I endometrioid carcinoma

description: Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb).It is the result of the abnormal growth of cells that have the ability to invade or spread to other parts of the body. The first sign is most often vaginal bleeding not associated with a menstrual period. Other symptoms include pain with urination or sexual intercourse, or pelvic pain. Endometrial cancer occurs most commonly after menopause. In stage I, the cancer is only growing in the body of the uterus. It may also be growing into the glands of the cervix, but is not growing into the supporting connective tissue of the cervix.


vaginal tubulovillous adenoma

description: An adenoma that arises from the vagina and is characterized by a tubulovillous architectural pattern.


name: vulvar keratinizing squamous cell carcinoma

description: A squamous cell carcinoma that arises from the vulva and is characterized by the presence of keratin pearls.


name: cerebrofacial arteriovenous metameric syndrome type 3


acanthoma

description: A benign skin neoplasm composed of epithelial cells.


intracranial cavernous angioma

description: A cavernous hemangioma arising from the brain and meninges.


vulvar apocrine adenocarcinoma

description: An apocrine adenocarcinoma that arises from the sweat glands in the vulva.


thymus clear cell carcinoma

description: A rare, usually aggressive, primary thymic carcinoma, characterized by the presence of carcinoma cells with clear cytoplasm.


micronodular basal cell carcinoma

description: A basal cell carcinoma of the skin characterized by the presence of small nodules that permeate the dermis. It presents as an elevated or flat infiltrating tumor, usually in the back.


warty carcinoma of the penis

description: A squamous cell carcinoma that arises from the penis. It is characterized by a papillary growth pattern, hyperkeratosis and parakeratosis. Koilocytotic atypia is present. Human papillomavirus types 16 and 6 have been identified in some cases.


chief cell adenoma

description: A parathyroid gland adenoma composed predominantly of neoplastic chief cells. These cells have either slightly eosinophilic or vacuolated cytoplasm, and round nuclei.


sphenoid sinus inverted papilloma

description: A benign neoplasm that arises from the ciliated respiratory mucosa that lines the sphenoid sinus. It results from the invagination and proliferation of epithelial cells in the underlying stroma.


name: primary peritoneal serous/papillary carcinoma

description: A rare, serous papillary adenocarcinoma that arises from the lining of the peritoneum. It affects females. The clinical behavior and pathologic characteristics are similar to the serous papillary adenocarcinoma that arises from the ovary.


fallopian tube carcinosarcoma

description: A carcinosarcoma that arises from the fallopian tube. It usually affects postmenopausal women and presents with abdominal pain, abdominal distension or genital bleeding. The prognosis is usually poor.


thymoma type B1

description: A thymic epithelial neoplasm characterized by the presence of expanded areas which resemble the normal thymic cortex. The neoplastic epithelial cells are small and scant and there is a dense T-lymphocytic component present. Areas of medullary differentiation with or without Hassall's corpuscles are also present. It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. It has a low grade malignant potential. The majority of cases occur in the anterior mediastinum as Masaoka stage I tumors. A minority of the cases occur as stage II tumors.


description: A rare cutaneous lesion presenting as a scaly verrucous plaque. Morphologically, the plaque contains nests of basaloid cells.


urethral urothelial papilloma

description: Papilloma's are benign epithelial neoplasms that produce visible warty projections from epithelial surfaces. Papilloma's of the urethra typically occur just within or on the external meatus. - 2003


bladder squamous papilloma

description: A rare, benign neoplasm of bladder that is composed of papillary cores with overlying histologically benign squamous epithelium.


vulvar nodular hidradenoma

description: A benign neoplasm that arises from sweat glands in the vulva and is characterized by the presence of lobules composed of epithelial cells with clear cytoplasm.


nodular hidradenoma

description: A benign epithelial neoplasm arising from the sweat glands. It presents as a nodular lesion usually in the scalp, trunk, and proximal extremities. It is characterized by a nodular growth pattern. Complete excision is curative.


exocervical carcinoma

description: A carcinoma that arises from the squamous epithelium of the exocervix.


scrotum basal cell carcinoma

description: A scrotal carcinoma that involves the basal cell.


skin squamous cell carcinoma in situ

description: Intraepidermal squamous cell carcinoma, confined to the epidermis. There is no evidence of invasion.


ethmoid sinus cancer

description: A malignant neoplasm involving the ethmoid sinus.


rete testis adenoma

description: A benign epithelial neoplasm arising from the rete testis.


name: kidney pelvis sarcomatoid transitional cell carcinoma

description: An infiltrating transitional cell carcinoma that arises from the renal pelvis and exhibits sarcomatoid features.


sphenoid sinus squamous cell carcinoma

description: A squamous cell carcinoma that arises from the mucosal epithelial surface of the sphenoid sinus. Patients may present with nasal fullness, obstruction, and/or epistaxis.


brain hemangioma

description: A hemangioma arising from the brain.


acantholytic acanthoma

description: A benign epithelial neoplasm of the skin. It presents as a papular or nodular lesion. Morphologically, it is characterized by the presence of hyperkeratosis, acanthosis, papillomatosis, and prominent acantholysis.


name: uterine ligament papillary cystadenoma associated with von Hippel-Lindau disease

description: A benign mesonephric neoplasm that arises from the uterine ligament and occurs in women with von Hippel-Lindau disease. It is a cystic lesion characterized by the presence of multiple papillary excrescences.


vulvar neuroendocrine carcinoma

description: A neuroendocrine carcinoma that arises from the vulva. This category includes small cell and large cell neuroendocrine carcinoma. Most small cell neuroendocrine carcinomas of the vulva are Merkel cell carcinomas.


villous adenocarcinoma

description: An adenocarcinoma characterized by the presence of a villous architectural pattern. It may arise from a villous adenoma.


hereditary kidney oncocytoma

description: An inherited condition characterized by the development of kidney oncocytomas which are often bilateral and multifocal. This condition may be connected to Birt-Hogg-Dube syndrome.


eye carcinoma

description: A carcinoma that arises from epithelial cells of the eye


breast myoepitheliosis

description: A multifocal neoplastic process characterized by the proliferation of spindle to cuboidal myoepithelial cells within and/or around small breast ducts.


cervical basaloid carcinoma

description: An aggressive variant of cervical squamous cell carcinoma characterized by the presence of nests of malignant basaloid squamous cells with scant amount of cytoplasm.


serous surface papilloma

description: A non-invasive papillary serous epithelial neoplasm usually arising from the ovary.


intraductal breast papillomatosis

description: A benign breast neoplasm characterized by the proliferation of multiple papillomas within the lumen of the ducts.


cavernous hemangioma of face

description: A cavernous hemangioma arising from the face.


adenocarcinoma of skene gland origin

description: A rare adenocarcinoma arising from Skene gland. It presents as a periurethral or anterior vaginal submucosal mass. It is characterized by morphological features similar to prostate adenocarcinoma.


thymic adenosquamous carcinoma

description: A rare carcinoma that arises from the thymus and is characterized by the presence of glandular and squamous carcinomatous components.


vulvar eccrine porocarcinoma

description: An eccrine porocarcinoma that arises from the sweat glands in the vulva.


hereditary renal cell carcinoma

description: An instance of renal cell carcinoma (disease) that is caused by an inherited modification of the individual's genome.


sweat gland adenoma

description: A benign epithelial neoplasm arising from the sweat glands. Representative examples include tubular apocrine adenoma, syringofibroadenoma, and hidradenoma.


pituitary gland acidophil adenoma

description: An epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic dyes.


sarcomatoid basal cell carcinoma

description: A basal cell carcinoma of the skin characterized by the presence of sarcomatoid features.


name: cervical non-keratinizing squamous cell carcinoma

description: A variant of cervical squamous cell carcinoma characterized by the presence of polygonal squamous cells. Intercellular bridges and cytoplasmic keratinization may be present, but keratin pearls are absent.


paranasal sinus sarcoma

description: A malignant soft tissue neoplasm that arises from the paranasal sinus.


fallopian tube mucinous tumor

description: A rare borderline or malignant epithelial tumor of the fallopian tube characterized by the presence of neoplastic epithelial cells that contain intracytoplasmic mucin and may resemble the epithelial cells of the endocervix or gastrointestinal tract.


peritoneal serous adenocarcinoma

description: A rare, serous adenocarcinoma that arises from the lining of the peritoneum. It affects females. The clinical behavior and pathologic characteristics are similar to the serous adenocarcinoma that arises from the ovary.


cervical adenoid basal carcinoma

description: A rare low grade carcinoma that arises from the cervix. It is characterized by the presence of nests of basaloid cells with focal glandular formations.


lipoadenoma

description: An adenoma in which the neoplastic epithelial cells are admixed with adipose tissue cells.


hemangioma of gingiva

description: A hemangioma that involves the gingiva.


follicular basal cell carcinoma

description: A basal cell carcinoma of the skin that is characterized by follicular differentiation.


bladder mixed adenocarcinoma

description: A variant of bladder adenocarcinoma that histologically consists of more than one growth pattern such as enteric, mucinous or signet ring types.


name: infiltrating renal pelvis transitional cell carcinoma

description: A infiltrating urothelial carcinoma that involves the renal pelvis.


urinary bladder villous adenoma

description: An exophytic glandular neoplasm of the bladder, morphologically similar to its intestinal counterpart. It often coexists with in situ or infiltrating bladder adenocarcinoma.


borderline ovarian serous tumor

description: A low grade serous epithelial neoplasm arising from the ovary. It is characterized by an atypical proliferation of serous-type epithelial cells without evidence of stromal invasion. It is often asymptomatic but rarely it may present with abdominal pain or abdominal enlargement due to rupture or torsion.


labia minora carcinoma

description: A carcinoma that arises from the labia minora.


name: glycogen-rich clear cell breast carcinoma

description: An uncommon, usually aggressive adenocarcinoma of the breast characterized by the presence of clear cells that contain glycogen.


name: poorly differentiated thymic neuroendocrine carcinoma


hemangioma of retina

description: A hemangioma that involves the retina.


ethmoid sinus Schneiderian papilloma

description: A papilloma that arises from the ciliated respiratory mucosa that lines the ethmoid sinus. It is classified as inverted papilloma and oncocytic papilloma.


sarcomatoid transitional cell carcinoma

description: A poorly differentiated transitional cell carcinoma characterized by the presence of malignant cells with spindle cell morphologic features.


bladder verrucous carcinoma

description: A verrucous carcinoma that involves the urinary bladder.


name: breast carcinoma by gene expression profile

description: A header term that includes the following breast carcinoma subtypes determined by gene expression profiling: luminal A breast carcinoma, luminal B breast carcinoma, HER2 positive breast carcinoma, basal-like breast carcinoma, triple-negative breast carcinoma, and normal breast-like subtype of breast carcinoma.


Cobb syndrome

description: Cobb syndrome is defined by the association of vascular cutaneous (venous or arteriovenous), muscular (arteriovenous), osseous (arteriovenous) and medullary (arteriovenous) lesions at the same metamere or spinal segment. This segmental distribution may involve one or many of the 31 metameres present in humans. Only 16% of the medullary lesions are multiple and have a clearly metameric distribution.


papillary hidradenoma

description: A benign neoplasm arising from the sweat glands. It presents as a slow growing cystic nodular lesion most often in the skin of the vulva and the perianal region. It is characterized by the presence of cystic and large papillary structures. The papillary structures contain connective tissue and are covered by two layers of epithelium. Complete excision is curative.


description: A variant of cervical squamous cell carcinoma characterized by the presence of islands of cells with uniform, vesicular nuclei and prominent nucleoli and a dense lymphocytic infiltrate.


mesonephric neoplasm

description: An epithelial neoplasm of the female reproductive system arising from mesonephric remnants.


capillary infantile hemangioma

description: Capillary hemangiomas are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma. Hemangiomas are classified as distinct from vascular malformations, in that the latter are present from birth, tend to grow with the individual, do not regress, and show normal rates of endothelial cell turnover.


ovarian mucinous neoplasm

description: A benign, borderline, or malignant epithelial tumor of the ovary characterized by the presence of neoplastic epithelial cells that contain intracytoplasmic mucin and may resemble the epithelial cells of the endocervix or gastrointestinal tract.


fallopian tube papillary adenocarcinoma

description: An adenocarcinoma that arises from the fallopian tube and is characterized by a papillary architectural pattern.


squamous cell skin papilloma

description: A squamous papilloma that involves the zone of skin.


name: pituitary adenoma, growth hormone-secreting, 2

description: Any pituitary gland adenoma in which the cause of the disease is a mutation in the GPR101 gene.


name: ovarian clear cell malignant adenofibroma

description: A carcinoma arising from the ovary. It is characterized by the presence of malignant epithelial cells with clear cytoplasm in a fibrotic stroma.


ureter adenocarcinoma

description: A carcinoma that arises from glandular epithelial cells of the ureter


central nervous system hemangioma

description: A hemangioma arising from the brain and spinal cord.


skin pilomatrix carcinoma

description: A very rare, locally aggressive, malignant neoplasm of the hair follicle. The majority of the cases arise de novo, however malignant transformation from a pre-existing pilomatricoma has been reported. It usually presents as a solitary nodule in the head and neck, upper extremities, or buttocks. Morphologically, it is characterized by the presence of aggregates of basaloid cells infiltrating the dermis. Masses of ghost cells are present in the cellular aggregates. Complete surgical excision is the treatment of choice. If it is not completely removed, it usually recurs, but it rarely metastasizes to distant anatomic sites.


breast hemangioma

description: A capillary or cavernous hemangioma arising from the breast.


vulvar seborrheic keratosis

description: A benign squamous neoplasm that arises from the vulva. It is characterized by the proliferation of the basal cells in the squamous epithelium, acanthosis, hyperkeratosis, and cysts formation.


cervical mucinous adenocarcinoma

description: A usually well to moderately differentiated cervical adenocarcinoma characterized by the presence of malignant glandular cells that contain significant amount of intracytoplasmic mucin.


Littre gland carcinoma

description: A carcinoma involving a male urethral gland.


Foix-Alajouanine syndrome

description: Foix-Alajouanine syndrome, also called subacute ascending necrotising myelitis, results from chronic congestion of the extrinsic pial veins of the spinal cord and of the intrinsic subpial network. It is characterized by progressive ascending deficit over a period of several months or years.


skin lymphangiosarcoma

description: A malignant vascular neoplasm of the skin arising from the lymphatic vessels.


transitional cell neoplasm

description: A benign or malignant, primary or metastatic neoplasm affecting the transitional cells.


name: cerebrofacial arteriovenous metameric syndrome type 1


prostatic acinar adenocarcinoma

description: An invasive adenocarcinoma of the prostate gland composed of secretory cells. It is the most common histologic type of prostate adenocarcinoma. Several morphologic variants exist, including atrophic, pseudohyperplastic, foamy gland, and oncocytic variants.


name: fallopian tube endometrioid adenocarcinoma

description: An adenocarcinoma that arises from the fallopian tube and resembles the endometrioid adenocarcinoma of the uterus. It usually has a favorable prognosis.


urinary bladder inverted papilloma

description: A neoplasm of the bladder in which the epithelial cells grow downward into the underlying supportive tissue, which often causes hematuria.


name: urinary tract non-invasive transitional cell neoplasm

description: A non-invasive neoplasm affecting the urothelium.


thymic sarcomatoid carcinoma

description: A rare, usually aggressive, primary thymic carcinoma, characterized by the presence of tumor cells morphologically resembling soft tissue sarcoma.


thymoma type AB

description: A thymic epithelial neoplasm characterized by the presence of a lymphocyte-poor component similar to that seen in type A thymoma and a lymphocyte-rich component which contains neoplastic small polygonal epithelial cells. It may be associated with myasthenia gravis and pure red cell aplasia. The majority of cases occur in the anterior mediastinum as Masaoka stage I tumors. A minority of the cases occur as stage II or stage III tumors. The overall survival is reported to be 80-100% at 5 and 10 years.


solid papillary breast carcinoma

description: A well circumscribed, low grade neoplasm that arises from the breast. It is characterized by the presence of sheets of malignant epithelial cells that are supported by fibrovascular structures. When there is an invasive component present, it is usually a mucinous carcinoma.


name: multilocular clear cell renal cell carcinoma

description: A rare type of renal cell carcinoma. It is a well-circumscribed multicystic mass without solid areas. The inner lining of the cystic structures is composed of clear cells.


mucoepidermoid breast carcinoma

description: A carcinoma of the breast characterized by pools of mucin and islands of malignant squamous cells. Mucoepidermoid carcinomas of the breast are extremely rare.


vulvar angiokeratoma

description: An uncommon benign lesion in the vulva. It manifests with multiple papular lesions which are purple in color. They are usually asymptomatic. Histologically, there is hyperkeratosis, papillomatosis, and dilated blood vessels in the papillary dermis.


minor vestibular glands adenoma

description: A rare, benign neoplasm that arises from the vulva It is characterized by the presence of clusters of small glands lined by mucinous epithelial cells. Bartholin duct structures are not present.


breast apocrine carcinoma

description: An adenocarcinoma of the breast characterized by the presence of two intermingled cellular components: cells with abundant granular, eosinophilic cytoplasm, and cells with abundant cytoplasm containing fine empty vacuoles.


intraductal breast papilloma

description: A benign papillary neoplasm that arises anywhere in the ductal system of the breast. It is characterized by fibrovascular structures lined by benign epithelial and myoepithelial proliferations. Intraductal breast papillomas are classified as central, when they arise in large ducts, or peripheral, when they arise in the terminal ductal lobular units.


cerebral hemangioma

description: A hemangioma arising from the cerebral hemisphere.


name: classic variant of chromophobe renal cell carcinoma

description: A variant of chromophobe renal cell carcinoma. It is characterized by the presence of large pale cells with thickened cell membranes.


name: cervical adenosquamous carcinoma, glassy cell variant

description: A poorly differentiated variant of adenosquamous carcinoma that arises from the cervix. It is characterized by the presence of large malignant cells with ground glass cytoplasm and stromal eosinophilic infiltrates.


name: human papillomavirus-related penile squamous cell carcinoma

description: A squamous cell carcinoma that arises from the penis and is caused by human papillomavirus infection. Morphologic variants include basaloid carcinoma and warty carcinoma.


name: spindle cell variant squamous cell breast carcinoma

description: A squamous cell carcinoma that arises from the breast parenchyma and is characterized by the presence of spindle-shaped malignant cells.


adamantinoid basal cell epithelioma

description: A rare but aggressive type of basal skin carcinoma. It is characterized by the presence of a meshwork of stellate tumor cells. It occurs most commonly in the nose and ears.


nasal cavity adenocarcinoma

description: A carcinoma that arises from glandular epithelial cells of the nasal cavity


papillary adenoma

description: An adenoma characterized by the presence of papillary epithelial patterns.


nipple duct carcinoma

description: A carcinoma that develops in the ducts of the nipple.


frontal sinus squamous cell carcinoma

description: A squamous cell carcinoma that arises from the mucosal epithelial surface of the frontal sinus. Patients may present with nasal fullness, obstruction, and/or epistaxis.


bladder urachal squamous cell carcinoma

description: A rare variant of bladder urachal carcinoma with squamous cell features.


name: growth hormone secreting pituitary adenoma 1


papillary carcinoma of the cervix uteri

description: A papillary carcinoma that involves the uterine cervix.


rete ovarii adenoma

description: An adenoma that arises from the rete ovarii. It is composed of elongated tubules. The clinical course is benign.


external ear basal cell carcinoma

description: A basal cell carcinoma that arises from the skin of the external ear.


name: extraovarian Brenner tumor of the vagina

description: A Brenner tumor that involves the vagina.


atypical breast papilloma

description: An intraductal papilloma of the breast characterized by the presence of focal epithelial atypia.


name: vulvar non-keratinizing squamous cell carcinoma

description: A squamous cell carcinoma that arises from the vulva and is characterized by the absence of keratin pearls.


granular cell carcinoma

description: An adenocarcinoma characterized by the presence of malignant epithelial cells with granular cytoplasm.


cervical endometrioid adenocarcinoma

description: A cervical adenocarcinoma with the histologic characteristics of the endometrioid adenocarcinoma of the endometrium.


skin adenosquamous carcinoma

description: An uncommon carcinoma that arises from the skin. It is characterized by the presence of malignant glandular and malignant squamous cellular components.


paranasal sinus Schneiderian papilloma

description: A papilloma that arises from the ciliated respiratory mucosa that lines the paranasal sinuses. It is classified as inverted papilloma and oncocytic papilloma.


urethra inverted papilloma

description: A neoplasm of the urethra in which the epithelial cells grow downward into the underlying supportive tissue.


nipple carcinoma

description: A carcinoma that arises from epithelial cells of the nipple


littoral cell angioma of the spleen

description: Littoral cell angioma is a rare primary vascular neoplasm of the spleen, composed of littoral cells that line the splenic sinuses of the red pulp. It was thought to be a benign, incidental lesion. However, many recent reports have described it to be a malignant lesion with congenital and immunological associations. The definitive diagnosis can only be made after histology and immunohistochemistry studies.


ovarian seromucinous tumor

description: A benign, borderline, or malignant mixed epithelial tumor of the ovary. It is characterized by the presence of more than one epithelial cell type, most often serous and endocervical-type mucinous.