description: Catalysis of the reaction: H+ + (9R,10S)-dihydroxystearate + O2 + NADPH = 9,10,18-trihydroxystearate + H2O + NADP.


name: indole-3-acetate carboxyl methyltransferase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: indole-3-acetate + S-adenosyl-L-methionine = methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine.


description: Catalysis of the reaction: 4-chloro-2-methylphenoxyacetate + 2-oxoglutarate + O2 = 4-chloro-2-methylphenol + 2-oxo monocarboxylic acid anion + succinate + carbon dioxide.


3-chlorotoluene monooxygenase activity

description: Catalysis of the reaction: H+ + 3-chlorotoluene + NADH + O2 = 3-chlorobenzyl alcohol + NAD + H2O.


name: gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming)

description: Catalysis of the reaction: gibberellin A53 + 2-oxoglutarate + O2 = gibberellin A97 + succinate + carbon dioxide.


description: Catalysis of the reaction: GDP-alpha-D-mannose + beta-D-fructofuranose 6-phosphate = mannosylfructose-phosphate + GDP.


description: Catalysis of the reaction: 2 H+ + 2 a reduced ferredoxin + an oxidized thioredoxin = 2 an oxidized ferredoxin + a reduced thioredoxin, involving a 4Fe-4S cluster and an adjacent active-site disulfide.


description: Catalysis of the reaction: (Kdo)2-lipid A + 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate = (beta-L-Ara4N)2-(KDO)2-lipid A + 2 ditrans,polycis-undecaprenyl phosphate.


description: Catalysis of the reaction: AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H+ + L-cysteinyl-[protein].


1-deoxy-D-xylulose kinase activity

description: Catalysis of the reaction: 1-deoxy-D-xylulose + ATP = H+ + 1-deoxy-D-xylulose 5-phosphate + ADP.


ITPase activity

description: Catalysis of the reaction: ITP + H2O = IDP + H+ + phosphate.


fructose-1-phosphatase activity

description: Catalysis of the reaction: beta-D-fructofuranose 1-phosphate + H2O = beta-D-fructofuranose + hydrogenphosphate.


murein hydrolase activity

description: Catalysis of the reaction: a peptidoglycan dimer (generic) = a lipid II + GlcNAc-1,6-anhydro-MurNAc-pentapeptide.


L-Ala-D/L-Glu epimerase activity

description: Catalysis of the reaction: L-alanyl-D-glutamate = L-alanyl-L-glutamate.


name: beta-galactosidase activity (lactose isomerization)

description: Catalysis of the reaction: alpha-lactose = beta-(1->6)-galactobiose.


description: Catalysis of the reaction: 5 H+ + NADH + a menaquinone = 4 H+ + NAD + a menaquinol.


name: L-glyceraldehyde 3-phosphate reductase activity

description: Catalysis of the reaction: sn-glycerol 3-phosphate + NADP = H+ + L-glyceraldehyde 3-phosphate + NADPH.


protein methylthiotransferase activity

description: Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [ribosomal protein S12] L-aspartate89 + a sulfurated [sulfur carrier] + a reduced electron acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2 H+ + a [ribosomal protein S12] 3-methylthio-L-aspartate89 + an unsulfurated [sulfur carrier] + an oxidized electron acceptor.


aldose sugar dehydrogenase activity

description: Catalysis of the reaction: H2O + an aldose + an oxidized electron acceptor = H+ + an aldonate + a reduced electron acceptor.


description: Catalysis of the reaction: hydroxidodioxidosulfidosulfate + a reduced thioredoxin = sulfite + hydrogen sulfide + H+ + an oxidized thioredoxin.


4-hydroxy-L-threonine aldolase activity

description: Catalysis of the reaction: 4-hydroxy-L-threonine = glycolaldehyde + glycine.


name: 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity

description: Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O = H+ + alpha-D-ribose 1,5-bisphosphate.


name: ribosomal protein S6 glutamate-glutamate ligase activity

description: Catalysis of the reaction: L-glutamate + ATP + a [protein] C-terminal L-glutamate = ADP + hydrogenphosphate + H+ + a [protein] with C-terminal alpha-L-glutamate-alpha-L-glutamate.


methione N-acyltransferase activity

description: Catalysis of the reaction: L-methionine + acetyl-CoA = N-acetyl-L-methionine + coenzyme A + H+.


alanylglutamate dipeptidase activity

description: Catalysis of the reaction: L-alanyl-L-glutamate + H2O = L-alanine + L-glutamate.


name: methyl beta-D-glucoside 6-phosphate glucohydrolase activity

description: Catalysis of the reaction: methyl beta-D-glucoside 6-phosphate + H2O = beta-D-glucose 6-phosphate + methanol.


name: gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming)

description: Catalysis of the reaction: gibberellin A12 + O2 + 2-oxoglutarate = gibberellin A15 + carbon dioxide + succinate.


name: gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity

description: Catalysis of the reaction: gibberellin A15 + 2-oxoglutarate + O2 = gibberellin A24 + succinate + carbon dioxide + H2O.


name: gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity

description: Catalysis of the reaction: gibberellin A53 + O2 + 2-oxoglutarate = gibberellin A44 diacid + carbon dioxide + succinate.


name: gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity

description: Catalysis of the reaction: gibberellin A19 + O2 + 2-oxoglutarate = H+ + gibberellin A20 + 2 carbon dioxide + succinate.


name: kaempferol 3-glucoside 7-O-rhamnosyltransferase activity

description: Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-L-rhamnose = kaempferol-3-glucoside-7-rhamnoside + UDP.


description: Catalysis of the reaction: kaempferol oxoanion + UDP-L-rhamnose = H+ + kaempferol-3-rhamnoside + UDP(3-).


name: kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity

description: Catalysis of the reaction: kaempferol-3-rhamnoside + UDP-L-rhamnose = kaempferol-3-rhamnoside-7-rhamnoside + UDP.


description: Catalysis of the reaction: ATP(4-) + H2O + a trans-methoxy-C60-meroacyl-[acp] = diphosphoric acid + a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein].


description: Catalysis of the reaction: ATP(4-) + H2O + a cis-keto-C60-meroacyl-[acp] = diphosphoric acid + a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein].


description: Catalysis of the reaction: ATP(4-) + H2O + a trans-keto-C61-meroacyl-[acp] = diphosphoric acid + a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein].


name: inositol phosphorylceramide mannosyltransferase activity

description: Catalysis of the reaction: a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1,6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H+.


name: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity

description: Catalysis of the reaction: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 4alpha-methyl-5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H.


name: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity

description: Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H.


name: leukotriene C4 gamma-glutamyl transferase activity

description: Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid.


description: Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


name: straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity

description: Catalysis of the reaction: a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA = formyl-CoA + an odd numbered straight chain 2,3,4-saturated fatty aldehyde.


description: Catalysis of the reaction: NAD + D-glucopyranose 6-phosphate = NADH + H+ + 3-dehydro-D-glucose 6-phosphate.


description: Catalysis of the reaction: 3-(indol-3-yl)pyruvate + NADPH + O2 + H+ = indole-3-acetate + carbon dioxide + NADP + H2O.


name: quercetin 3-glucoside 7-O-rhamnosyltransferase activity

description: Catalysis of the reaction: quercetin-3-glucoside + UDP-L-rhamnose = quercetin-3-O-glucoside-7-O-rhamnoside + UDP.


name: quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity

description: Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose = quercetin-3-rhamnoside-7-rhamnoside + UDP.


description: Catalysis of the reaction: 5-methylthio-2-oxopentanoate + acetyl-CoA + H2O = H+ + 2-(3-methylthiopropyl)malate + coenzyme A.


description: Catalysis of the reaction: 2-(3-methylthiopropyl)malate(2-) = 3-(3'-methylthio)propylmalate.


description: Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + acetyl-CoA + H2O = H+ + 2-(4'-methylthio)butylmalate + coenzyme A.


description: Catalysis of the reaction: 2-(4'-methylthio)butylmalate = 3-(4'-methylthio)butylmalate.


description: Catalysis of the reaction: 2-oxo-7-methylthioheptanoate + acetyl-CoA + H2O = H+ + 2-(5'-methylthio)pentylmalate + coenzyme A.


description: Catalysis of the reaction: 2-(5'-methylthio)pentylmalate = 3-(5'-methylthio)pentylmalate.


description: Catalysis of the reaction: 2-oxo-8-methylthiooctanoate + acetyl-CoA + H2O = H+ + 2-(6'-methylthio)hexylmalate + coenzyme A.


description: Catalysis of the reaction: 2-(6'-methylthio)hexylmalate = 3-(6'-methylthio)hexylmalate.


description: Catalysis of the reaction: 2-oxo-9-methylthiononanoate + acetyl-CoA + H2O = H+ + 2-(7'-methylthio)heptylmalate + coenzyme A.


description: Catalysis of the reaction: 2-(7'-methylthio)heptylmalate = 3-(7'-methylthio)heptylmalate.


name: CYP79F1 dihomomethionine monooxygenase activity

description: Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH + 2 H+ = 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP.


name: CYP79F1 trihomomethionine monooxygenase activity

description: Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH + 2 H+ = 3 H2O + carbon dioxide + 2 NADP + 6-methylthiohexanaldoxime.


name: CYP79F1 tetrahomomethionine monooxygenase activity

description: Catalysis of the reaction: 2 H+ + tetrahomomethionine + 2 O2 + 2 NADPH = 3 H2O + carbon dioxide + 2 NADP + 7-methylthioheptanaldoxime.


description: Catalysis of the reaction: UDP-alpha-D-glucose + 5-methylthiopentylhydroximate = H+ + 4-methylthiobutyldesulfoglucosinolate + UDP.


name: UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity

description: Catalysis of the reaction: UDP-alpha-D-glucose + 6-methylthiohexylhydroximate = H+ + 5-methylthiopentyldesulfoglucosinolate + UDP(3-).


description: Catalysis of the reaction: UDP-alpha-D-glucose + 7-methylthioheptylhydroximate = H+ + 6-methylthiohexyldesulfoglucosinolate + UDP.


description: Catalysis of the reaction: UDP-alpha-D-glucose + 8-methylthiooctylhydroximate = H+ + 7-methylthioheptyldesulfoglucosinolate + UDP.


name: UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity

description: Catalysis of the reaction: UDP-alpha-D-glucose + 9-methylthiononylhydroximate = 8-methylthiooctyldesulfoglucosinolate + UDP + H+.


description: Catalysis of the reaction: 6-methylthiohexyldesulfoglucosinolate + 3'-phosphonato-5'-adenylyl sulfate = adenosine 3',5'-bismonophosphate + H+ + 6-methylthiohexylglucosinolate.


description: Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + a standard alpha amino acid = dihomomethionine + a 2-oxo carboxylate.


description: Catalysis of the reaction: brassinolide + UDP-alpha-D-glucose = brassinolide-23-O-glucoside + UDP + H+.


description: Catalysis of the reaction: castasterone + UDP-alpha-D-glucose = castasterone-23-O-glucoside + UDP + H+.


description: Catalysis of the reaction: N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in).


ABC-type D-galactofuranose transporter

description: Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O = alpha-D-galactofuranose + hydrogenphosphate + ADP + H+.


description: Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O = UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate.


description: Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + an (3R)-3-hydroxymyristoyl-[acp] = UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H+ + a holo-[acyl-carrier protein].


name: cellular response to environmental stimulus

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus.


intestinal hexose absorption

description: Uptake of hexoses, notably D-glucose, fructose, and galactose, into the blood by absorption from the small intestine.


mCRD-mediated mRNA stability complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP.


amyloid-beta complex

description: Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease.


tRNA (guanine-N7)-methylation

description: The process whereby a guanine in a tRNA is methylated at the N7 position of guanine.


RNA 5'-cap (guanine-N7)-methylation

description: The process whereby a guanine in 5-cap is methylated at the N7 position of guanine.


name: cytoskeletal protein-membrane anchor activity

description: The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a plasma membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific cortical membrane location.


name: microtubule anchoring at cell cortex of cell tip

description: Any process in which a microtubule is maintained in a specific location at the cell tip by attachment to the cell cortex.


2-oxoglutaramate amidase activity

description: Catalysis of the reaction: 2-oxoglutaramate + H2O = 2-oxoglutarate + NH3.


description: Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.


name: regulation of protein localization to medial cortex

description: Any process that regulates the localization of a protein to the medial cortex.


name: positive regulation of protein localization to medial cortex

description: Any process that activates or increases the frequency, rate or extent of protein localization to the medial cortex.


name: negative regulation of protein localization to cell cortex of cell tip

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the cell cortex of the cell tip.


name: regulation of inflammatory response to wounding

description: Any process that modulates the frequency, rate or extent of the inflammatory response to wounding.


name: negative regulation of inflammatory response to wounding

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding.


name: positive regulation of inflammatory response to wounding

description: Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.


regulation of vesicle docking

description: Any process that modulates the frequency, rate or extent of vesicle docking.


negative regulation of vesicle docking

description: Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle docking.


positive regulation of vesicle docking

description: Any process that activates or increases the frequency, rate or extent of vesicle docking.


regulation of pupariation

description: Any process that modulates the onset of pupariation.


negative regulation of pupariation

description: Any process that stops, prevents or reduces the rate of onset of pupariation.


positive regulation of pupariation

description: Any process that activates or increases the frequency, rate or extent of onset of pupariation.


Gly-tRNA(Ala) hydrolase activity

description: Catalysis of the hydrolysis of misacylated Gly-tRNA(Ala).


neuron projection organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite.


neuron projection retraction

description: The organization process which results in the disassembly (either partial or complete) of constituent parts of a neuron projection. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.


tRNA pseudouridine synthase activity

description: Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.


neuron projection fasciculation

description: The collection of neuronal projections into a bundle of rods, known as a fascicle.


snRNA pseudouridine synthase activity

description: Catalysis of the reaction: uridine in snRNA = pseudouridine in snRNA. Conversion of uridine in an snRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.


spine synapse

description: A type of synapse occurring between an axon and a dendritic spine.


name: protein maturation by [2Fe-2S] cluster transfer

description: The transfer of an assembled [2Fe-2S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.


name: protein maturation by [4Fe-4S] cluster transfer

description: The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.


name: assembly of apicomedial cortex actomyosin

description: A process which results in the assembly or arrangement of constituent parts apicomedial cortex actomyosin.


apicomedial cortex

description: The region that lies just beneath the plasma membrane in the middle of the apical edge of a cell.


regulation of GABA-A receptor activity

description: Any process that modulates the frequency, rate or extent of GABA-A receptor activity.


name: positive regulation of GABA-A receptor activity

description: Any process that activates or increases the frequency, rate or extent of GABA-A receptor activity.


name: negative regulation of GABA-A receptor activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of GABA-A receptor activity.


guanine deglycation

description: The removal of a sugar or dicarbonyl from a glycated guanine.


name: guanine deglycation, methylglyoxal removal

description: The removal of methylglyoxal from a glycated guanine, to form lactate and a deglycated guanine.


guanine deglycation, glyoxal removal

description: The removal of glyoxal from a glycated guanine, to form glycolate and a deglycated guanine.


polyamine deacetylation

description: The modification of acetylpolyamine by the removal of acetyl groups.


spermidine deacetylation

description: The modification of acetylspermadine by the removal of acetyl groups.


name: regulation of cellular response to osmotic stress

description: Any process that modulates the frequency, rate or extent of the cellular response to osmotic stress.


tRNA 2'-O-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide.


description: A protein complex capable of catalysing the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.


name: regulation of calcineurin-mediated signaling

description: Any process that modulates the frequency, rate or extent of calcineurin-mediated signaling.


name: negative regulation of calcineurin-mediated signaling

description: Any process that stops, prevents or reduces the frequency, rate or extent of calcineurin-mediated signaling.


name: positive regulation of calcineurin-mediated signaling

description: Any process that activates or increases the frequency, rate or extent of calcineurin-mediated signaling.


description: Catalysis of the reaction: S-adenosyl-L-methionine + cytidine56 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA.


regulation of exit from meiosis

description: Any process that modulates the frequency, rate or extent of exit from mitosis.


name: negative regulation of exit from meiosis

description: Any process that stops, prevents or reduces the frequency, rate or extent of exit from meiosis.


name: positive regulation of exit from meiosis

description: Any process that activates or increases the frequency, rate or extent of exit from meiosis.


name: G protein-coupled folate receptor activity

description: Combining with folate and transmitting the signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity.


name: regulation of cobalamin metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.


SUMO ligase complex

description: A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase and other proteins that may confer substrate specificity of the complex.


synapsis initiation complex

description: A SUMO-E3 ligase complex capable of promoting synapsis, the meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase.


name: regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway.


name: positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway.


name: negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway.


name: dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity

description: Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.


name: aminoacyl-tRNA metabolism involved in translational fidelity

description: Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation.


peptide N-succinyltransferase activity

description: Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide.


description: Catalysis of the reaction: succinyl-CoA + lysine in peptide = CoA + N-succinyl-lysine-peptide.


histone succinyltransferase activity

description: Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone.


GATOR1 complex binding

description: Binding to a GATOR1 complex.


maltose import across plasma membrane

description: The directed movement of maltose from outside of a cell, across the plasma membrane and into the cytosol.


sucrose import across plasma membrane

description: The directed movement of sucrose from outside of a cell, across the plasma membrane and into the cytosol.


nuclear membrane protein complex

description: Any protein complex that is part of the nuclear membrane.


name: mitotic nuclear membrane microtubule tethering complex

description: A protein complex capable of interacting with the spindle pole body and the nuclear envelope, in order to embed the spindle pole body in the nuclear envelope at fusion sites of the inner and outer nuclear membrane.


name: regulation of cell adhesion involved in sprouting angiogenesis

description: Any process that modulates the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis.


name: negative regulation of cell adhesion involved in sprouting angiogenesis

description: Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis.


name: positive regulation of cell adhesion involved in sprouting angiogenesis

description: Any process that activates or increases the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis.


glial cell projection elongation

description: The process of creating an elongation or projection from a glial cell.


name: glial cell projection elongation involved in axon ensheathment

description: The extension of a glial cell process or projection to wrap around an axon.


EDS1 disease-resistance complex

description: A plant complex involved in basal disease resistance and resistance (R) gene-mediated effector triggered immunity (ETI). Regulates accumulation of the hormone salicylic acid (SA) which is a necessary component of systemic immunity. Involved in responds to bacteria, viruses and oomycetes.


name: nuclear membrane microtubule tethering complex

description: A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links thereby links the nuclear lumen to cytoplasmic microtubules.


m7G(5')pppN diphosphatase complex

description: A homodimeric protein complex that catalyzes the reaction: 7-methylguanosine-5'-triphospho-5'-pholynucleotide + H20 = 7-methylguanosine-5'-phosphate + polynucleotide.


response to ceramide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus.


cellular response to ceramide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus.


NAGS/NAGK complex

description: A protein complex that acts both as N-acetylglutamate synthase (NAGS) catalysing the production of N-Acetylglutamate from glutamate and acetyl-CoA, and as N-acetylglutamate kinase (NAGK) catalysing the reaction ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate.


description: Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde.


beta-pinacene synthase activity

description: Catalysis of the cyclization of geranylgeranyl pyrophosphate (GGPP) to yield the monocyclic diterpene beta-pinacene.


ER-dependent peroxisome localization

description: A process in which a protein is transported to, or maintained at, a location in a peroxisome via the endoplasmic reticulum.


COPII vesicles tethering complex

description: A protein complex that resides in the cis-golgi membrane and plays a role in the tethering of COPII vesicles, through an interaction with vesicle tethering proteins (p115 in H. Sapiens and Uso1 S. cerevisiae), granting the cis-Golgi and endoplasmic reticulum to Golgi vesicle-mediated transport. It is composed by GRASP65 and GM130 protein in H. sapiens and by Bug1 and Grh1 proteins in S. cerevisiae.


name: regulation of glutamate receptor clustering

description: Any process that modulates the frequency, rate or extent of glutamate receptor clustering.


Ala-tRNA(Thr) hydrolase activity

description: Catalysis of the hydrolysis of misacylated ala-tRNA(thr).


cold-induced thermogenesis

description: The process by which heat is generated by increasing metabolism in response to cold ambient temperatures in order to maintain a stable core body temperature.


name: regulation of (R)-mevalonic acid biosynthetic process

description: Any process that modulates the frequency, rate or extent of (R)-mevalonic acid biosynthetic process.


name: negative regulation of (R)-mevalonic acid biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of (R)-mevalonic acid biosynthetic process.


name: positive regulation of (R)-mevalonic acid biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of (R)-mevalonic acid biosynthetic process.


vomitoxin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of type B trichothecene vomitoxin, also known as deoxynivalenol, a poisonous substance produced by some species of fungi and predominantly occurs in grains such as wheat, barley and oats.


name: regulation of mitotic cohesin ssDNA (lagging strand) loading

description: Any process that modulates the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading.


name: negative regulation of mitotic cohesin ssDNA (lagging strand) loading

description: Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading.


name: positive regulation of mitotic cohesin ssDNA (lagging strand) loading

description: Any process that activates or increases the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading.


name: regulation of mitotic cohesin dsDNA (leading strand) loading

description: Any process that modulates the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading.


name: negative regulation of mitotic cohesin dsDNA (leading strand) loading

description: Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading.


name: positive regulation of mitotic cohesin dsDNA (leading strand) loading

description: Any process that activates or increases the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading.


acidocalcisome organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an acidocalcisome. An acidocalcisome is an electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations.


name: regulation of sterol biosynthetic process

description: Any process that modulates the frequency, rate or extent of a sterol biosynthetic process.


name: negative regulation of sterol biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of a sterol biosynthetic process.


name: positive regulation of sterol biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of a sterol biosynthetic process.


name: positive regulation of cobalamin metabolic process

description: Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process.


name: negative regulation of cobalamin metabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of a cobalamin metabolic process.


reservosome

description: A large membrane-bound endocytic organelle present only in members of the Schizotrypanum subgenus of the Trypanosoma genus and is defined as the site of storage of endocytosed macromolecules and lysosomal enzymes. It is found at the posterior end of epimastigote forms of Trypanosoma cruzi, but absent in amastigotes and trypomastigotes.


reservosome lumen

description: The volume enclosed by the membranes of a reservosome.


reservosome matrix

description: A matrix composed of planar membranes, vesicles and lipid inclusions within the reservosome.


reservosome membrane

description: The lipid bilayer surrounding a reservosome.


name: negative regulation of store-operated calcium entry

description: Any process that stops, prevents or reduces the frequency, rate or extent of store-operated calcium entry.


name: positive regulation of store-operated calcium entry

description: Any process that activates or increases the frequency, rate or extent of store-operated calcium entry.


description: Catalysis of the reaction: RMP + diphosphate = R + 5-phospho-alpha-D-ribose 1-diphosphate.


name: positive regulation of cardiac muscle cell contraction

description: Any process that activates or increases the frequency, rate or extent of cardiac muscle cell contraction.


name: negative regulation of cardiac muscle cell contraction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell contraction.


name: lectin-induced modified bacterial internalization

description: The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by secretion of lectins which bind to the bacterial surface. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.


IkappaB kinase complex binding

description: Binding to a IkappaB kinase complex.


Sec61 translocon complex binding

description: Binding to a Sec61 translocon complex.


symbiont cell surface

description: The cell surface of a secondary, endosymbiont organism with which the first organism is interacting. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.


P-TEFb complex binding

description: Binding to a P-TEFb complex.


flavin prenyltransferase activity

description: Catalysis of the reaction: dimethylallylphosphate + FMNH2 = prenylated FMNH2 + phosphate.


description: Catalysis of the reaction: S-adenosyl-L-methionine + adenine(645) in 25S rRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(645) in 25S rRNA.


tRNA (m7G46) methyltransferase complex

description: A protein complex involved in the catalysis of the formation of the modified nucleotide 7-methylguanine (at position 46 in certain tRNAs, such as tRNA(phe) and tRNA(met). In yeast, it is a heterotetramer of two subunits, Trm8 (catalytic) and Trm82 (WD repeat).


fraxetin 5-hydroxylase activity

description: Catalyzes the reaction fraxetin+ NAD(P)H + 02= sideretin + NAD(P)(+) + H20.


scopoletin 8-hydroxylase activity

description: Catalyzes of the reaction: scopoletin + 2-oxoglutarate+O2=fraxetin +succinate+ CO2).


sideretin biosynthesis

description: The chemical reactions and pathways resulting in the formation of sideretin.


fraxetin biosynthesis

description: The chemical reactions and pathways resulting in the formation of fraxetin.


name: 4-hydroxyindole-3- carbonyl nitrile biosynthesis

description: The chemical reactions and pathways resulting in the formation of 4-hydroxyindole-3- carbonyl nitrile (4-OH-ICN), a cyanogenic glucoside.


name: indole-3-carbonyl nitrile 4-hydroxylase activity

description: Catalysis of the reaction: indole-3-carbonyl nitrile + NADPH +O2=4-hydroxyindole-3- carbonyl nitrile + NADP+ + H20.


zearalenone biosynthetic process

description: The chemical reactions and pathways resulting in the formation of zearalenone, a mycotoxin produced by several Fusarium species, is most commonly found as a contaminant in stored grain and has chronic estrogenic effects on mammals.


CNBH domain intrinsic ligand binding

description: Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide.


phosphorylated histone binding

description: Binding to a histone in which a residue has been modified by phosphorylation.


perithecium formation

description: The process of producing flask-shaped fruiting bodies, called perithecia. In the ascomycetous fungi such as Neurospora crassa and Sordaria macrospora, these perithecia are formed in the sexual phase and they discharge ascospores through the ostiolum at the tip of the perithecial neck.


peptidyl-lysine 3-dioxygenase activity

description: Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 3-hydroxy-L-lysine + succinate + CO2.


peptidyl-lysine 4-dioxygenase activity

description: Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 4-hydroxy-L-lysine + succinate + CO2.


description: Catalyzes the reaction: 2-oxoglutarate + [protein]-L-arginine + O2 = [protein]-(3R)-3-hydroxy-L-arginine + CO2 + succinate.


description: Catalysis of the reaction:acyl-CoA + glycerophosphocholine = CoA + 1-acyl-sn-glycero-3-phosphocholine.


mRNA N-acetyltransferase activity

description: Catalysis of the reaction: a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H+ + phosphate.


name: spindle pole body-nuclear membrane anchor activity

description: The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body.


extracellular ATP signaling

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals mediated by the detection of extracellular ATP.


COPI-coated vesicle lumen

description: The volume enclosed by the membrane of a COPI-coated endocytic vesicle.


COPII-coated vesicle lumen

description: The volume enclosed by the membrane of a COPII-coated endocytic vesicle.


phagolysosome vesicle lumen

description: The volume enclosed by the membrane of a phagolysosome.


phagolysosome vesicle membrane

description: The lipid bylayer surrounding a phagolysosome.


clathrin-coated endocytic vesicle lumen

description: The volume enclosed by the membrane of a clathrin-coated endocytic vesicle.


cyclic-GMP-AMP hydrolase activity

description: Catalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP.


name: cytoplasmic side of plasma membrane, cell tip

description: The leaflet the plasma membrane at the cell tip that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.


culmorin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of culmorin, a sesquiterpenoid fungal metabolite and mycotoxin produced by some ascomycete species such as Fusarium culmorum, F. graminearum, F. venenatum and Leptosphaeria oraemaris.


description: Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H+ + phosphate.


name: centromere detachment from spindle pole body involved in meiotic chromosome organization

description: The cell cycle process in which centromeres dissociate from the spindle pole body, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I.


name: kinetochore disassembly involved in meiotic chromosome organization

description: The cell cycle process in which outer kinetochore components delocalize from the centromere, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I.


name: regulation of vesicle fusion with Golgi apparatus

description: Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus.


name: negative regulation of vesicle fusion with Golgi apparatus

description: Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus.


name: positive regulation of vesicle fusion with Golgi apparatus

description: Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus.


tRNA C3-cytosine methylation

description: The process whereby a cytosine in a tRNA is methylated at position 3 of the cytosine.


description: The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactosaminogalactan. GAG is a heteropolysaccharide composed of alpha-1,4 linked galactose, N-acetyl galactosamine (GalNAc) and galactosamine (GalN).


zinc ion sensor activity

description: Binding to and responding, e.g. by conformational change, to changes in the cellular level of zinc.


pyocyanine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pyrocyanin, an iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group.


lncRNA binding

description: Binding to a long noncoding RNA (lncRNA).


germacrene A hydroxylase activity

description: Catalysis of the reaction:(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase].


description: The 2-hydroxyisobutyrylation of a lysine residue in a protein.


description: Catalysis of the reaction: 2-hydroxyisobutyryl-CoA + lysine in peptide = CoA + N-2-hydroxyisobutyryl-lysine-peptide.


peptidyl-lysine glutarylation

description: The glutarylation of a lysine residue in a protein.


peptide glutaryltransferase activity

description: Catalysis of the reaction: glutaryl-CoA + L-lysyl-[protein] = CoA + H+ + N6-glutaryl-L-lysyl-[protein].


histone glutaryltransferase activity

description: Catalysis of the reaction: glutaryl-CoA + histone = CoA + H+ + N6-glutaryl-histone.


protein depropionylation

description: The removal of a propionyl group from a residue in a peptide or protein.


description: Catalysis of the reaction:H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD+ = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.


hydroxyisourate hydrolase complex

description: A hydrolase complex that converts 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline. This is the second step of the three-step enzymatic reaction that degrades uric acid to (S)-allantoin.


glycosome organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a glycosome, a membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis.


outer membrane protein complex

description: Any protein complex that is part of the bacterial outer membrane. An example In E.coli, is RcsF associated with any one of several outer membrane beta-barrel proteins (OMPs), such as OmpA, OmpF, or OmpcC.


description: Catalysis of the reaction: ceramide-1-phosphate + H2O = ceramide+ phosphate.


rhamnolipid biosynthesis

description: The chemical reactions and pathways resulting in the formation/production of a glycolipid surfactant that acts as a bacterial biofilm dispersal.


description: Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12R,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.


name: peregrinol diphosphate synthase activity

description: Catalysis of the reaction:peregrinol diphosphate = all-trans-geranylgeranyl diphosphate + H2O.


description: Catalysis of the reaction:peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate.


description: Catalysis of the reaction:O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H+ + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase].


kolavenyl diphosphate synthase activity

description: Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate.


description: Catalysis of the reaction: 9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene.


eupatolide synthase activity

description: Catalysis of the reaction: 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase].


description: Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine.


name: regulation of poly(A)-specific ribonuclease activity

description: Any process that modulates the rate, frequency or extent of the catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.


name: negative regulation of poly(A)-specific ribonuclease activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of poly(A)-specific ribonuclease activity.


name: positive regulation of poly(A)-specific ribonuclease activity

description: Any process that activates or increases the frequency, rate or extent of poly(A)-specific ribonuclease activity.


Nicalin-NOMO complex

description: A protein complex regulating Nodal signaling. Subunits are highly conserved in vertebrates and include Nicalin, NOMO and TMEM147.


name: DNA-binding transcription repressor activity, RNA polymerase III-specific

description: A DNA-binding transcription factor activity that represses or decreases the transcription of specific genes sets transcribed by RNA polymerase III.


description: Catalysis of the reaction N4-acetylcytidine +H2O = cytidine + acetate.


name: positive regulation of DNA strand resection involved in replication fork processing

description: Any process that activates or increases the frequency, rate or extent of DNA strand resection involved in replication fork processing.


lipid sensor activity

description: Binding to and responding, e.g. by conformational change, to changes in the cellular level of a lipid.


name: hydroperoxy icosatetraenoate isomerase activity

description: A hydroperoxy icosatetraenoate = a hydroxy epoxy icosatrienoate.


name: hydroperoxy icosatetraenoate dehydratase activity

description: A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H2O.


description: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline.


name: symbiont-mediated cell-to-cell migration in host

description: The directional movement of a symbiont from one host cell to another.


DNA-DNA tethering activity

description: Bridging together two regions of a DNA molecule.


name: tRNA uridine(34) acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H+ + L-methionine.


description: Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA.


description: Catalysis of the reaction:a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA.


name: protein serine kinase activity (using GTP as donor)

description: Catalysis of the reactions: GTP + L-seryl-[protein] = GDP + H+ + O-phospho-L-seryl-[protein].


THPH synthase activity

description: Catalysis of the reaction: 3 H+ + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA.


3-chloro THPH synthase activity

description: Catalysis of the reaction: 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H+ + 2 H2O.


3,5 dichloro-THPH synthase activity

description: Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O.


name: 3,5-dichloro-THPH methyl transferase activity

description: Catalysis of the reaction: (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H+ + S-adenosyl-L-homocysteine.


name: D-arabinose 1-dehydrogenase (NADP+) activity

description: Catalysis of the reaction: D-arabinose + NADP+ = D-arabinono-1,4-lactone + NADPH.


protein localization to ERGIC

description: A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum-Golgi intermediate compartment (ERGIC).


cytosol to ERGIC protein transport

description: The directed movement of proteins from the cystosol to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC).


description: Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide.


biliberdin reductase NAD+ activity

description: Catalysis of the reaction: bilirubin + NAD+ = biliverdin + NADH+ H+.


biliverdin reductase (NADPH) activity

description: Catalysis of the reaction: bilirubin + NADP+ = biliverdin + NADPH + H+.


name: regulation of UDP-N-acetylglucosamine biosynthetic process

description: Any process that modulates the frequency, rate or extent of the UDP-N_acetylglucosamine biosynthetic process.


name: negative regulation of UDP-N-acetylglucosamine biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process.


name: positive regulation of UDP-N-acetylglucosamine biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process.


name: chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity

description: Catalysis of the reaction: chenodeoxycholate + NAD+ = 7-oxolithocholate + H+ + NADH.


name: isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity

description: Catalysis of the reaction: 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD+ = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H+ + NADH.


name: ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity

description: Catalysis of the reaction: NAD+ + ursodeoxycholate = 7-oxolithocholate + H+ + NADH.


(E)-caffeate-CoA ligase activity

description: Catalysis of the reaction: (E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate.


name: regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA

description: Any process that modulates the frequency, rate or extent of deadenylation-dependent decapping of nuclear-transcribed mRNA.


name: negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA

description: Any process that stops, prevents, or reduces the frequency, rate or extent of deadenylation-dependent decapping of nuclear-transcribed mRNA.


trans-cinnamate-CoA ligase activity

description: Catalysis of the reaction: (E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate.


name: superoxide-generating NADH oxidase activity

description: Catalysis of the reaction: NADH + 2 O2 = H+ + NAD+ + 2 superoxide.


name: superoxide-generating NADPH oxidase activity

description: Catalysis of the reaction: NADPH + 2 O2 = H+ + NADP+ + 2 superoxide.


NADH oxidase H202-forming activity

description: Catalysis of the reaction: NADH + H+ + O2 = NAD + hydrogen peroxide (H2O2).


NADPH oxidase H202-forming activity

description: Catalysis of the reaction: NADPH + H+ + O2 = NADP + hydrogen peroxide (H2O2).


resolvin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of resolvins, di- or trihydroxy fatty acids derived from omega-3 polyunsaturated fatty acids, specifically icosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid.


D-series resolvin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of resolvin family D-series, hydroxy fatty acids derived from docosahexaenoic acid.


E-series resolvin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of resolvin family E-series, hydroxy fatty acids derived from icosapentaenoic acid.


13-series resolvin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of resolvin family 13-series, hydroxy fatty acids derived from docosapentaenoic acid.


resolution phase response

description: An active host response phase of acute inflammation driven by specialized pro-resolving mediators (SPMs) and signaling pathways, enabling timely tissue regeneration and return of function.


name: protein-DNA covalent cross-linking repair

description: The removal of covalent cross-link between DNA and a protein.


name: arachidonic acid 5,6-epoxygenase activity

description: Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-5,6-epoxyeicosatrienoic acid.


name: arachidonic acid 8,9-epoxygenase activity

description: Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-8,9-epoxyeicosatrienoic acid.


mannogen metabolic process

description: The chemical reactions and pathways involving mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania.


mannogen biosynthetic process

description: The chemical reactions and pathways resulting in the formation of mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania.


mannogen catabolic process

description: The chemical reactions and pathways resulting in the breakdown of mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania.


progesterone 21-hydroxylase activity

description: Catalysis of the reaction: O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


protein serine kinase activity

description: Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.


name: methylenetetrahydrofolate reductase (NADH) activity

description: Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD+ = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADH + H+.


name: methylenetetrahydrofolate reductase (NADPH) activity

description: Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP+ = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H+.


nitrite reductase NADH activity

description: Catalysis of the reaction: ammonium hydroxide + 3 NAD+ + H2O = nitrite + 3 NADH + 3 H+.


name: S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity

description: Catalysis of the reaction: S-(hydroxymethyl)glutathione + NADP+ = S-formylglutathione + NADPH + H+.


name: S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity

description: Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD+ = S-formylglutathione + NADH + H+.


description: Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP.


description: Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP.


L-phenylalaine oxidase activity

description: Catalysis of the reaction: H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+).


sialate 9-O-acetylesterase activity

description: Catalysis of the reaction: H2O + N-acetyl-9-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate.


sialate 4-O-acetylesterase activity

description: Catalysis of the reaction: H2O + N-acetyl-4-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate.


name: ds/ssDNA junction-specific dsDNA endonuclease activity

description: Catalysis of the endonucleolytic cleavage of double-stranded DNA near a double-strand/single-strand DNA junction.


subcortical maternal complex

description: Comprised of at least NLRP5, OOEP, TLE6, and KHDC3/KHDC3L with evidence of additional SCMC-associated proteins that interact with one or multiple members of the core complex.


3'-deoxyribose phosphate lyase activity

description: Catalysis of the conversion of a 3'-deoxyribose phosphate in DNA to a 3'-phosphate.


description: Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine.


yolk syncytial layer development

description: The progression of the yolk syncytial layer over time, from its initial formation to the mature structure. The yolk syncytial layer is the peripheral layer of the yolk cell including nuclei and non-yolky cytoplasm.


description: Catalysis of the reaction: S-adenosyl-L-methionine + cytosine32 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine32 in tRNA.


description: Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 34 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 34 in tRNA.


description: Catalysis of the reaction: 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine.


description: The chemical reactions and pathways resulting in the formation of omega-hydroxyceramide/acylceramide.


glutarate dioxygenase activity

description: Catalysis of the reaction glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2.


name: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP

description: Catalysis of the reaction: 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H+ + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase].


glyoxylate reductase activity

description: Catalysis of the reaction: glycolate + NAD(P)+ = glyoxylate + NAD(P)H.


snRNA methyltransferase activity

description: Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an snRNA molecule.


name: U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity

description: Catalysis of the reaction: a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+.


name: U2 snRNA adenosine m6 methyltransferase activity

description: Catalysis of the reaction: a adenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-adenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+.


snRNA methylation

description: The posttranscriptional addition of methyl groups to specific residues in an snRNA molecule.


name: octaprenyl pyrophosphate synthase activity

description: Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate.


tRNA surveillance

description: The set of processes involved in identifying and degrading defective or aberrant tRNAs.


name: 4-hydroxybenzoate 3-monooxygenase (NADH) activity

description: Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD+.


name: 4-hydroxybenzoate 3-monooxygenase (NADPH) activity

description: Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+.


name: glycerol-1-phosphate dehydrogenase (NAD+) activity

description: Catalysis of the reaction: NAD+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADH.


name: glycerol-1-phosphate dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADPH.


2-hydroxyacyl-CoA lyase activity

description: Catalysis of the reaction: a 2-hydroxy fatty acyl-CoA = a fatty aldehyde + formyl-CoA. The reaction acts on 2-hydroxy-3-methyl-branched fatty acyl-CoA and 2-hydroxy-long-chain fatty acyl-CoA.


description: Catalysis of the reaction: dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H+ + N(omega)-(L-rhamnosyl)-L-arginyl-[protein].


description: Catalysis of the reaction: L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H+ + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP.


description: Catalysis of the reaction: L-cysteinyl-[protein] + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein].


description: 4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin].


beta-carotene isomerase activity

description: Catalyzes the reaction: all-trans-beta-carotene = 9-cis-beta-carotene.


guanosine kinase activity

description: Catalysis of the reaction: ATP + guanosine = ADP + GMP.


name: (deoxy)nucleoside phosphate kinase activity, dGTP as phosphate donor

description: Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP.


name: (deoxy)nucleoside phosphate kinase activity, dTTP as phosphate donor

description: Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP.


name: (deoxy)nucleoside phosphate kinase activity, GTP as phosphate donor

description: Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP.


description: Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine.


name: fluorescent chlorophyll catabolite monooxygenase (deformylase) activity

description: Catalysis of the reaction: O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H+ + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite.


name: primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity

description: Catalysis of the reaction: H2O + primary fluorescent dioxobilin-type chlorophyll catabolite = H+ + methanol + O13(4)-desmethyl pFCC.


3-deoxyglucosone dehydrogenase activity

description: Catalysis of the reaction: 3-deoxyglucosone + H2O + NAD+ = 2-dehydro-3-deoxy-D-gluconate + 2 H+ + NADH.


name: deoxynucleoside triphosphate hydrolase activity

description: Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate.


2-hydroxyphytanoyl-CoA lyase activity

description: Catalysis of the reaction: 2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA.


2-hydroxy-ATP hydrolase activity

description: Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + H+ + diphosphate.


2-hydroxy-dATP hydrolase activity

description: Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + H+ + diphosphate.


8-oxo-(d)RTP hydrolase activity

description: Catalysis of the reaction: 8-oxo-(d)RTP + H20 = 8-oxo-(d)RMP + diphosphate + H+.


purine ribonucleotide salvage

description: Any process which produces a purine ribonucleotide from derivatives of it, without de novo synthesis.


purine deoxyribonucleotide salvage

description: Any process which produces a purine deoxyribonucleotide from derivatives of it, without de novo synthesis.


dAMP salvage

description: Any process which produces a dAMP from derivatives of it, without de novo synthesis.


dGMP salvage

description: Any process which produces a dGMP from derivatives of it, without de novo synthesis.


dIMP salvage

description: Any process which produces a dIMP from derivatives of it, without de novo synthesis.


name: (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity

description: Catalysis of the reaction: 3R-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.


'de novo' GMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of guanosine 5'-monophosphate (GMP) through an inosine 5'-monophosphate (IMP) intermediate.


name: 18S rRNA aminocarboxypropyltransferase activity

description: Catalysis of the reaction: N1-methylpseudouridine in 18S rRNA + S-adenosyl-L-methionine = H+ + N1-methyl-N3-[(3S)-3-amino-3-carboxypropyl]pseudouridine in 18S rRNA + S-methyl-5'-thioadenosine.


ecdysteroid 22-kinase activity

description: Catalysis of the reaction: an ecdysteroid + ATP = an ecdysteroid 22-phosphate + ADP + H+.


bI4 intron splicing complex

description: A protein complex required for the splicing of intron 4 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI4 (which derives from one of the products of the splicing), Leucyl-tRNA synthetase NAM2 and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing.


bI3 intron splicing complex

description: Aprotein complex required for the splicing of intron 3 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI3 (which derives from one of the products of the splicing), the MRS1 cofactor and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing.


name: regulation of palmitic acid catabolic process

description: Any process that modulates the frequency, rate or extent of a palmitic acid catabolic process.


name: negative regulation of palmitic acid catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of a palmitic acid catabolic process.


name: positive regulation of palmitic acid catabolic process

description: Any process that activates or increases the frequency, rate or extent of a palmitic acid catabolic process.


regulation of R7 cell fate commitment

description: Any process that modulates the frequency, rate or extent of R7 cell fate commitment.


name: positive regulation of R7 cell fate commitment

description: Any process that activates or increases the frequency, rate or extent of R7 cell fate commitment.


name: negative regulation of R7 cell fate commitment

description: Any process that stops, prevents or reduces the frequency, rate or extent of R7 cell fate commitment.


name: double-strand break repair via transcription-associated homologous recombination

description: A mechanism of homologous recombination and DNA repair in which transcript RNA is used as a template for DSB repair.


Lewis x epitope biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a Lewis x epitope, a trisaccharide (beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-beta-D-glucosamine) expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system. The related Lewis x epitope is formed by alpha(1,3) fucosylation of the N-acetylglucosaminyl residue of a type 2 histo-blood group antigen precursor disaccharide.


name: isoprenoid diphosphate phosphatase activity

description: Catalysis of the dephosphorylation of isoprenoid diphosphates.


name: Glc2Man9GlcNAc2 oligosaccharide glucosidase activity

description: Catalysis of the reaction: Glc(2)Man(9)GlcNAc(2)-[protein] + H2O = GlcMan(9)GlcNAc(2)-[protein] + beta-D-glucopyranose.


diadenylate cyclase activity

description: Catalysis of the reaction: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate.


description: Catalysis of the reaction: 3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-5')-adenosine + H+.


box C/D sno(s)RNA 5'-end processing

description: Any process involved in forming the mature 5' end of a box C/D RNA molecule.


XMP 5'-nucleosidase activity

description: Catalysis of the reaction: 5'XMP + H20 = phosphate + xanthosine.


RNA dihydrouridine synthase activity

description: Catalysis of the reaction: RNA-uracil + NAD(P)+ = RNA-dihydrouridine + NAD(P)H + H+.


mRNA dihydrouridine synthase activity

description: Catalysis of the reaction: mRNA-uracil + NAD(P)+ = mRNA-dihydrouridine + NAD(P)H+ + H+.


description: GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H2O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine.


dopaminechrome tautomerase activity

description: Catalysis of the reaction: dopaminechrome = 5,6-dihydroxyindole.


description: Catalysis of the reaction: ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate.


name: NAD-dependent protein lipoamidase activity

description: Catalysis of the reaction: (R)-N6-lipoyl-L-lysyl-[protein] + H2O + NAD+ = 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.


name: NAD-dependent protein biotinidase activity

description: Catalysis of the reaction: H2O + N6-biotinyl-L-lysyl-[protein] + NAD+ = 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.


name: L-glutamate:proton antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamate(out) + H+(in) = L-glutamate(in) + H+(out).


carotenoid isomerooxygenase activity

description: Catalysis of the reaction: Zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal.


tubulin-tyrosine carboxypeptidase

description: Catalysis of the reaction: C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine.


description: Catalysis of the reaction: L-dopa + O2 + H2O + H+ = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH(4)+ + H2O2.


name: regulation of kainate selective glutamate receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of the kainate selective glutamate receptor signaling pathway.


name: negative regulation of kainate selective glutamate receptor signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of the kainate selective glutamate receptor signaling pathway.


name: positive regulation of kainate selective glutamate receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the kainate selective glutamate receptor signaling pathway.


11-cis-retinol dehydrogenase

description: Catalysis of the reaction:11-cis-retinol-[retinal-binding-protein] + NAD+ = 11-cis-retinal-[retinol-binding-protein] + NADH.


name: dihydroorotate dehydrogenase (quinone) activity

description: (S)-dihydroorotate + a quinone = orotate + a quinol.


N6-methyl-(d)ATP hydrolase activity

description: Catalysis of the reaction N6-methyl-(d)ATP + H2O = N6-methyl-(d)AMP + diphosphate + H+.


queuosine nucleosidase activity

description: Catalysis of the reaction: a N-D-queuosine + H2O = queuine + D-ribose.


O6-methyl-dGTP hydrolase activity

description: Catalysis of the reaction O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+.


retinal isomerization

description: The reactions involved in isomerization of all trans to all cis retnal.


carboxylesterase activity

description: Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+.


name: glutathione-dependent sulfide quinone oxidoreductase activity

description: Catalysis of the reaction: a quinone + glutathione + H+ + hydrogen sulfide = a quinol + S-sulfanylglutathione.


name: protein-glutamic acid ligase activity, initiating

description: Catalytic reaction: ATP + L-glutamate + L-glutamyl-[protein] = ADP + H+ + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate.


name: protein-glutamic acid ligase activity, elongating

description: Catalytic reaction :(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H+ + phosphate.


name: L-lysine:L-arginine antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out).


toxin-antitoxin complex

description: A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon.


regulation of tRNA methylation

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA methylation.


name: regulation of tRNA C5-cytosine methylation

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA C5-cytosine methylation.


positive regulation of tRNA methylation

description: Any process that activates or increases the frequency, rate or extent of tRNA methylation.


name: positive regulation of tRNA C5-cytosine methylation

description: Any process that activates or increases the frequency, rate or extent of tRNA C5-cytosine methylation.


name: formin-nucleated actin cable organization

description: A process that results in the assembly, arrangement of constituent parts, or disassembly of a formin-nucleated actin cable.


basolateral protein secretion

description: The controlled release of proteins from a cell at the sides which interface adjacent cells and near the base.


name: regulation of basement membrane organization

description: Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane.


protein localization to P-body

description: Any process in which a protein is transported to, or maintained at, a P-body.


name: positive regulation of aggregation involved in sorocarp development

description: Any process that increases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.


name: negative regulation of aggregation involved in sorocarp development

description: Any process that decreases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.


name: positive regulation of elastin catabolic process

description: Any process that activates or increases the frequency, rate or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin.


B-WICH complex

description: A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself.


name: cap-independent translational initiation of linear mRNA

description: The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation.


name: cap-independent translational initiation of circular RNA

description: The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate circRNA translation.


name: IRES-dependent translational initiation of circular RNA

description: The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate circular mRNA translation.


name: regulation of actomyosin structure organization

description: Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin.


cardiac muscle myoblast proliferation

description: The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.


name: regulation of cardiac muscle myoblast proliferation

description: Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation.


name: negative regulation of cardiac muscle myoblast proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation.


name: positive regulation of cardiac muscle myoblast proliferation

description: Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation.


name: DNA strand resection involved in replication fork processing

description: The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing.


name: regulation of DNA strand resection involved in replication fork processing

description: Any process that modulates the frequency, rate or extent of DNA strand resection involved in replication fork processing.


name: negative regulation of DNA strand resection involved in replication fork processing

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA strand resection involved in replication fork processing.


name: positive regulation of mitotic spindle organization

description: Any process that activates or increases the frequency, rate or extent of mitotic spindle organization.


negative regulation of meiosis I

description: Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.


name: regulation of G2/MI transition of meiotic cell cycle

description: Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle.


name: negative regulation of G2/MI transition of meiotic cell cycle

description: Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle.


name: positive regulation of G2/MI transition of meiotic cell cycle

description: Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle.


name: regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway, the series of molecular signals generated as a consequence of glucose binding to a G protein-coupled receptor, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).


name: negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway.


name: rDNA spacer replication fork barrier binding, bending

description: The activity of binding selectively, and in a sequence-specific manner, a replication fork barrier found in rDNA spacers, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.


C2 domain binding

description: Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes.


name: regulation of nematode male tail tip morphogenesis

description: Any process that modulates the frequency, rate or extent of nematode male tail tip morphogenesis, the process in which the anatomical structure of the adult male tail tip is generated and organized.


name: negative regulation of nematode male tail tip morphogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of nematode male tail tip morphogenesis.


name: positive regulation of nematode male tail tip morphogenesis

description: Any process that activates or increases the frequency, rate or extent of nematode male tail tip morphogenesis.


nematode pharynx morphogenesis

description: The process in which the anatomical structures of the nematode pharynx are generated and organized.


name: regulation of nematode pharynx morphogenesis

description: Any process that modulates the frequency, rate or extent of nematode pharynx morphogenesis, the process in which the anatomical structure of the pharynx is generated and organized.


name: negative regulation of nematode pharynx morphogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of nematode pharynx morphogenesis.


name: positive regulation of nematode pharynx morphogenesis

description: Any process that activates or increases the frequency, rate or extent of nematode pharynx morphogenesis.


name: regulation of cell cycle switching, mitotic to meiotic cell cycle

description: Any process that modulates the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division.


name: negative regulation of cell cycle switching, mitotic to meiotic cell cycle

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division.


deaminated glutathione amidase activity

description: Catalysis of the reaction: N-(4-oxoglutarate)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine.


metabolite repair

description: A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites.


toxic metabolite repair

description: A cellular process that, through single- or multi-step enzymatic reactions, repairs toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites.


name: regulation of actin filament organization

description: Any process that modulates the frequency, rate or extent of actin filament organization.


regulation of actin filament annealing

description: Any process that modulates the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments.


name: negative regulation of actin filament annealing

description: Any process that stops, prevents or reduces the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments.


name: positive regulation of actin filament annealing

description: Any process that activates or increases the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments.


name: regulation of blood vessel endothelial cell differentiation

description: Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation.


name: positive regulation of blood vessel endothelial cell differentiation

description: Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation.


name: negative regulation of blood vessel endothelial cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation.


name: regulation of angiotensin-activated signaling pathway

description: Any process that modulates the frequency, rate or extent of the angiotensin-activated signaling pathway.


name: negative regulation of angiotensin-activated signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the angiotensin-activated signaling pathway.


name: positive regulation of angiotensin-activated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the angiotensin-activated signaling pathway.


lncRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of lncRNAs, non-coding RNAs over 200 nucleotides in length.


name: regulation of interphase mitotic telomere clustering

description: Any process that modulates the frequency, rate or extent of mitotic telomere clustering during interphase.


name: negative regulation of interphase mitotic telomere clustering

description: Any process that stops, prevents, or reduces the frequency, rate or extent of mitotic telomere clustering during interphase.


name: ammonium transmembrane transporter complex

description: High affinity ammonium transporter complex that enables the transfer of ammonium from one side of a membrane to the other.


description: Catalysis of the reaction: glucosylglycerate + phosphate = glucose-1-phosphate + D-glycerate.


syncytial embryo cellularization

description: The separation of a syncytial embryo into individual cells.


cellularization cleavage furrow

description: A plasma membrane invagination at the site of separation of a multi-nucleate cell or syncytium into individual cells.


name: cellularization cleavage furrow invagination front

description: The base of the cellularization invagination or cleavage furrow most distal to the original multi-nucleate cell or syncytium plasma membrane.


name: apical constriction involved in ventral furrow formation

description: The actin-mediated process that results in contraction of the apical end of a polarized columnar epithelial cell, contributing to formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation.


name: regulation of apical constriction involved in ventral furrow formation

description: Any process that modulates the frequency, rate or extent of apical constriction involved in ventral furrow formation.


name: positive regulation of apical constriction involved in ventral furrow formation

description: Any process that activates or increases the frequency, rate or extent of apical constriction involved in ventral furrow formation.


regulation of ferroptosis

description: Any process that modulates the frequency, rate or extent of ferroptosis.


negative regulation of ferroptosis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of ferroptosis.


description: A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane.


TTT Hsp90 cochaperone complex

description: A Hsp90 cochaperone complex acting as an adapter between Hps90 and its substrates, members of the PIKK kinase family.


name: regulation of placenta blood vessel development

description: Any process that modulates the frequency, rate or extent of placenta blood vessel development.


name: positive regulation of placenta blood vessel development

description: Any process that activates or increases the frequency, rate or extent of placenta blood vessel development.


name: negative regulation of placenta blood vessel development

description: Any process that stops, prevents or reduces the frequency, rate or extent of placenta blood vessel development.


name: regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly

description: Any process that modulates the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly.


name: positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly

description: Any process that activates or increases the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly.


name: negative regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly.


mitotic actomyosin contractile ring

description: A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the mitotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the mitotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the mitotic contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis.


meiotic actomyosin contractile ring

description: A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the meiotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the meiotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In fungal cells, the meiotic contractile ring forms beneath the plasma membrane of the prospore envelope in preparation for completing cytokinesis.


hippocampal neuron apoptotic process

description: Any apoptotic process that occurs in a hippocampal neuron.


name: regulation of hippocampal neuron apoptotic process

description: Any process that modulates the occurrence or rate of cell death by apoptotic process in hippocampal neurons.


name: positive regulation of hippocampal neuron apoptotic process

description: Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons.


name: negative regulation of hippocampal neuron apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons.


nucleus leading edge

description: The area of a motile nucleus closest to the direction of movement.


nucleus lagging edge

description: The area of a motile nucleus furthest from the direction of movement.


polyphosphate-mediated signaling

description: Any process that mediates the transfer of information from one cell to another using polyphosphate as the signal.


cellular detoxification of aldehyde

description: Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.


cellular response to aldehyde

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde stimulus.


name: regulation of calcium import into the mitochondrion

description: Any process that modulates the frequency, rate or extent of calcium import into the mitochondrion.


name: positive regulation of calcium import into the mitochondrion

description: Any process that activates or increases the frequency, rate or extent of calcium import into the mitochondrion.


name: negative regulation of calcium import into the mitochondrion

description: Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into the mitochondrion.


spindle pole body separation

description: The release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble.


name: L-valine transmembrane import into vacuole

description: The directed movement of L-valine into the vacuole across the vacuolar membrane.


name: ribulose bisphosphate carboxylase complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a ribulose bisphosphate carboxylase complex.


RNA polymerase II termination complex

description: A conserved protein complex capable of 5'-3' exoribonuclease activity. It is able to promote RNA polymerase II (RNAPII) transcription termination by degrading pre-mRNA from the newly formed 5' phosphorylated end.


mRNA alternative polyadenylation

description: The process of generating multiple mRNA molecules with variable 3'-end length formation from a given pre-mRNA by differential use of cleavage and polyadenylation signals (pA signals).


name: mRNA cleavage and polyadenylation specificity factor complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form the mRNA cleavage and polyadenylation specificity factor complex.


name: regulation of imaginal disc-derived wing vein specification

description: Any process that modulates the frequency, rate or extent of imaginal disc-derived wing vein specification.


name: positive regulation of imaginal disc-derived wing vein specification

description: Any process that activates or increases the frequency, rate or extent of imaginal disc-derived wing vein specification.


name: negative regulation of imaginal disc-derived wing vein specification

description: Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived wing vein specification.


name: positive regulation of animal organ morphogenesis

description: Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis.