name: cardiac endothelial to mesenchymal transition

description: A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes.


regulation of lipoprotein transport

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that controls lipoprotein transport.


name: negative regulation of lipoprotein transport

description: Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport.


name: positive regulation of lipoprotein transport

description: Any process that activates or increases the rate or extent of lipoprotein transport.


name: class I DNA-(apurinic or apyrimidinic site) endonuclease activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.


glycosylated region protein binding

description: Binding to a glycosylated region of a protein.


SUMO-ubiquitin ligase activity

description: Isoenergetic transfer of SUMO from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.


name: ATP-dependent protein-DNA unloader activity

description: Facilitating the removal of a protein or protein complex from a DNA molecule driven by ATP hydrolysis. This can be achieved for example by introducing non-canonical DNA structures or generating torque to directly inhibit a protein-DNA binding interaction.


sexual macrocyst formation

description: The fusion of haploid amoebae cells with matching mating types to form a larger cell, which ingests additional amoebae and forms a cellulose wall. The resulting macrocyst undergoes recombination and meiosis followed by release of haploid amoebae. An example of this process can be found in Dictyostelium discoideum.


membrane curvature sensor activity

description: Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins.


mBAF complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A muscle cell-specific SWI/SNF-type complex that contains eight to fourteen proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes, and the muscle-specific product of the DPF3/BAF45C gene or an ortholog thereof.


bBAF complex

description: A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180.


esBAF complex

description: An embryonic stem cell-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or an ortholog thereof. Compared to many other BAF complexes never contains ACTL6B/BAF53B, ARID1B/BAF250B, SMARCA2/BRM, SMARCC2/BAF170 or SMARCD3/BAF60C but contains PHF10/BAF45A, DPF2/BAF45D and possibly one of BCL7A/B/C.


catalytic activity, acting on a protein

description: Catalytic activity that acts to modify a protein.


catalytic activity, acting on DNA

description: Catalytic activity that acts to modify DNA.


catalytic activity, acting on RNA

description: Catalytic activity that acts to modify RNA, driven by ATP hydrolysis.


catalytic activity, acting on a tRNA

description: Catalytic activity that acts to modify a tRNA.


catalytic activity, acting on a rRNA

description: Catalytic activity that acts to modify a ribosomal RNA.


name: catalytic activity, acting on a glycoprotein

description: Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein.


molecular carrier activity

description: Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location.


category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by interleukin-10 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: high-affinity potassium ion transmembrane transporter activity

description: Enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


name: high-affinity glucose transmembrane transporter activity

description: Enables the transfer of glucose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


transcription regulator activity

description: A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons.


name: [choline trimethylamine-lyase]-activating enzyme activity

description: Catalyzes the activation of choline trimethylamine-lyase by generation of an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM).


extracellular vesicle biogenesis

description: The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.


extracellular microvesicle biogenesis

description: The assembly and secretion of a set of components to form an extracellular microvesicule, a membrane-bounded vesicle that ranges in size 100 nm to 1 micron in size) and exits the cell by budding.


cellular detoxification of fluoride

description: Any process carried out at the cellular level that reduces or removes the toxicity of a fluoride. These may include chemical modification or transport of fluoride away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.


export across plasma membrane

description: The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region.


fluoride export across plasma membrane

description: The directed movement of fluoride ions from inside of a cell, across the plasma membrane and into the extracellular region.


Lewy body formation

description: The aggregation, arrangement and bonding together of a set of components to form a Lewy body.


regulation of Lewy body formation

description: Any process that modulates the frequency, rate or extent of Lewy body formation.


name: negative regulation of Lewy body formation

description: Any process that stops, prevents or reduces the frequency, rate or extent of Lewy body formation.


name: positive regulation of Lewy body formation

description: Any process that activates or increases the frequency, rate or extent of Lewy body formation.


thiamine import across plasma membrane

description: The directed movement of thiamine from outside of a cell, across the plasma membrane and into the cytosol.


name: positive regulation of lymphocyte chemotaxis

description: Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis.


iron-sulfur cluster carrier activity

description: Binding to an iron-sulfur cluster and delivering it to an acceptor molecule.


name: symbiont-mediated suppression of host cytokine production

description: A process by which a symbiont inhibits or disrupts cytokine production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: mechanosensitive monoatomic cation channel activity

description: Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress.


name: mitochondrial guanine nucleotide transmembrane transport

description: The process in which a guanine nucleotide is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial potassium ion transmembrane transport

description: The process in which a potassium ion is transported across a mitochondrial membrane, into or out of the mitochondrion.


nucleocytoplasmic carrier activity

description: Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein.


copper ion export from vacuole

description: The directed movement of copper ions out of the vacuole across the vacuolar membrane.


calcium ion import into vacuole

description: The directed movement of calcium cations into the vacuole across the vacuolar membrane.


zinc ion export from vacuole

description: The directed movement of zinc ions from inside the vacuole across the vacuolar membrane and into the cytosol.


ammonium import across plasma membrane

description: The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol.


borate export across plasma membrane

description: The directed movement of borate from inside of a cell, across the plasma membrane and into the extracellular region.


description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in).


Golgi transport complex binding

description: Binding to a Golgi transport complex, a multisubunit tethering complex of the CATCHR family.


name: positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process

description: Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.


name: negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process

description: Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.


urea import across plasma membrane

description: The directed movement of urea from outside of a cell, across the plasma membrane and into the cytosol.


polyamine import across plasma membrane

description: The directed movement of a polyamine from outside of a cell, across the plasma membrane and into the cytosol.


name: spermidine import across plasma membrane

description: The directed movement of spermidine from outside of a cell, across the plasma membrane and into the cytosol.


pyridoxal import across plasma membrane

description: The directed movement of pyridoxal from outside of a cell, across the plasma membrane and into the cytosol.


name: oligopeptide import across plasma membrane

description: The directed movement of an oligopeptide from outside of a cell, across the plasma membrane and into the cytosol.


dipeptide import across plasma membrane

description: The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol.


name: tripeptide import across plasma membrane

description: The directed movement of a tripeptide from outside of a cell, across the plasma membrane and into the cytosol.


name: apoptotic process in response to mitochondrial fragmentation

description: Any apoptotic process that occurs as a result of mitochondrial fragmentation.


name: zinc ion import into endoplasmic reticulum

description: The directed import of zinc(2+) from the cytosol, across the endoplasmic reticulum membrane, into the endoplasmic reticulum.


name: protein transport along microtubule to kinetochore

description: Any process in which a protein is transported to the kinetochore along a microtubule.


folic acid:proton symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methyl THF, 5-formyl THF) and folic acid.


name: regulation of long-chain fatty acid import into cell

description: Any process that modulates the frequency, rate or extent of long-chain fatty acid import into a cell.


name: negative regulation of long-chain fatty acid import into cell

description: Any process that stops, prevents or reduces the frequency, rate or extent of long-chain fatty acid import into a cell.


name: positive regulation of long-chain fatty acid import into cell

description: Any process that activates or increases the frequency, rate or extent of long-chain fatty acid import into a cell.


name: regulation of D-aspartate import across plasma membrane

description: Any process that modulates the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.


name: negative regulation of D-aspartate import across plasma membrane

description: Any process that stops, prevents or reduces the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.


name: positive regulation of D-aspartate import across plasma membrane

description: Any process that activates or increases the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.


pathogen-containing vacuole

description: A membrane-bound intracellular compartment that is formed upon internalization of a pathogen into a host cell, and in which the pathogen resides.


pathogen-containing vacuole membrane

description: Host-derived membrane of a pathogen-containing vacuole.


pathogen-containing vacuole lumen

description: The enclosed volume within the sealed membrane of a pathogen-containing vacuole.


name: general transcription initiation factor activity

description: A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.


SLAC complex

description: A protein complex that regulates Arp2/3 complex-mediated actin nucleation.


name: DNA topoisomerase III-beta-TDRD3 complex

description: A protein complex that has DNA topoisomerase type I and RNA topoisomerase activities.


RNA topoisomerase activity

description: Catalysis of the transient cleavage and passage of individual RNA strands or double helices through one another, resulting a topological transformation in RNA.


name: serotonin-gated cation-selective signaling pathway

description: The series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.


name: anterograde axonal transport of neurotransmitter receptor complex

description: The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons.


name: intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential

description: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential.


name: intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential

description: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential.


RNA polyadenylation at postsynapse

description: A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse.


translation at presynapse

description: Translation that occurs at the presynapse.


name: translation at presynapse, modulating chemical synaptic transmission

description: Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.


presynaptic endocytosis

description: A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.


postsynaptic endocytosis

description: A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.


name: perforant pathway to dendrate granule cell synapse

description: A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus.


translation at synapse

description: Translation that occurs at the synapse.


translation at postsynapse

description: Translation that occurs at the postsynapse.


regulation of translation at synapse

description: Any process that regulates translation occurring at the synapse.


regulation of translation at presynapse

description: Any process that regulates translation occurring at the presynapse.


name: regulation of translation at postsynapse

description: Any process that regulates translation occurring at the postsynapse.


protein catabolic process at synapse

description: The chemical reactions and pathways resulting in the breakdown of a protein at a synapse.


protein catabolic process at presynapse

description: The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse.


name: protein catabolic process at postsynapse

description: The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse.


name: regulation protein catabolic process at synapse

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse.


name: regulation protein catabolic process at presynapse

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse.


name: regulation protein catabolic process at postsynapse

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse.


cell-cell fusion

description: A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium.


name: regulation of cellular response to phosphate starvation

description: Any process that modulates the frequency, rate or extent of cellular response to phosphate starvation.


name: negative regulation of cellular response to phosphate starvation

description: Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to phosphate starvation.


PRC1 complex binding

description: Binding to a PRC1 complex.


name: mitochondrial proton-transporting ATP synthase complex binding

description: Binding to a mitochondrial proton-transporting ATP synthase complex.


BCOR complex

description: A protein-containing complex that monoubiquitinates histone H2A on K119, thus it facilitates the maintenance of the transcriptionally repressive state of some genes, such as BCL6. It consists of the corepressor BCOR or BCORL1, a Polycomb group (PcG) and a SCF ubiquitin ligase subcomplexes. In mammals, the core subunits of the complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP and the components of the SCF ubiquitin ligase, SKP1, and FBXL10.


mRNA cap binding complex binding

description: Binding to a mRNA cap binding complex.


Woronin body

description: Peroxisome-derived dense-core vesicle that seals septal pores upon hyphal lysis to prevent excessive cytoplasmic loss. It is specific to several genera of filamentous ascomycetes.


name: symbiont entry into host cell via permeabilization of host membrane

description: The entry of a symbiont into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration symbiont protein. This process mediates the entry of some non-enveloped virus into host cells, and results in the release of the virus contents into the host cell cytoplasm.


name: endoplasmic reticulum-plasma membrane contact site

description: A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes.


gluconate import across plasma membrane

description: The directed movement of gluconate from outside of a cell, across the plasma membrane and into the cytosol.


hexose import across plasma membrane

description: The directed movement of hexose from outside of a cell, across the plasma membrane and into the cytosol.


exogenous protein binding

description: Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein.


name: repair of mitotic kinetochore microtubule attachment defect

description: The mitotic cell cycle process where kinetochore microtubule attachment defects are corrected.


name: repair of kinetochore microtubule attachment defect

description: The cell cycle process where kinetochore microtubule attachment defects are corrected.


MIB complex

description: A mitochondrial intermembrane space bridging complex consisting of components of the MICOS complex in the inner mitochondrial membrane, the SAM complex in the outer membrane, a conserved DNAJ protein (human DNAJC11) and Metaxin 1.


mitotic division septum assembly

description: The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following mitotic cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.


name: regulation of mitotic division septum assembly

description: Any process that modulates the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.


name: negative regulation of mitotic division septum assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.


name: positive regulation of mitotic division septum assembly

description: Any process that activates or increases the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.


name: carbon-nitrogen ligase activity on lipid II

description: Catalysis of the reaction: L-glutamine + lipid II + ATP + H2O = L-glutamate + beta-D-GlcNAc(1->4)-Mur2Ac(oyl-L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + ADP + phosphate.


name: endoplasmic reticulum-endosome membrane contact site

description: A contact site between the endoplasmic reticulum membrane and the endosome membrane.


endosome fission

description: The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane.


GBAF complex

description: A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM.


peptidyl-serine ADP-deribosylation

description: The removal of ADP-ribose from ADP-ribosylserine.


peptidyl-glutamate ADP-deribosylation

description: The removal of ADP-ribose from ADP-ribosylglutamate.


ADP-ribosylserine hydrolase activity

description: Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose.


ADP-ribosylglutamate hydrolase activity

description: Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose.


NAD DNA ADP-ribosyltransferase activity

description: Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA.


name: pathogen-derived receptor ligand activity

description: The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity.


name: general transcription initiation factor binding

description: Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation.


name: DNA-binding transcription factor binding

description: Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.


endocytic iron import into cell

description: Uptake of iron into a cell via binding to an extracellular receptor, which is internalized by endocytosis.


small molecule sensor activity

description: Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule.


serine import into mitochondrion

description: The process in which serine is transported from the cytosol into the mitochondrial matrix.


pollen-stigma interaction

description: The interactions (or cell to cell communication) that occur between the pollen grain (male gametophyte) and the stigmatic tissues of the female sporophyte after the pollen reaches the stigmatic papillae.


pollen-style interaction

description: The interactions (or cell to cell communication) that occur between the male gametophyte (pollen/pollen tube) and the stylar tissues of the female sporophyte.


name: intramembrane lipid transporter activity

description: Enables the transport of a lipid from a region of a membrane to a different region on the same membrane.


lipoprotein releasing activity

description: The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex.


protein sequestering activity

description: Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.


cargo adaptor activity

description: Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery.


molecular sequestering activity

description: Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.


calcium ion sequestering activity

description: Binding to a calcium ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.


iron ion sequestering activity

description: Binding to an iron ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.


export across cell outer membrane

description: The directed movement of a substance across the outer membrane in cells with two membranes.


protein transporter activity

description: Directly binding to a specific protein and delivering it to a specific cellular location.


receptor decoy activity

description: Binding and sequestering a specific receptor ligand to prevent it from binding to its regular receptor.


PAMP receptor decoy activity

description: Binding and sequestering PAMP ligands in order to prevent them from binding and activating to the host PAMP receptor. Usually this activity is encoded by a symbiont or a pathogen to prevent activation of the host innate immune response.


name: symbiont-mediated suppression of host autophagy

description: A process in which a symbiont inhibits or disrupts the normal execution of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: negative regulation of protein localization to medial cortex

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the medial cortex.


name: ATPase-coupled intramembrane lipid transporter activity

description: Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases.


flippase activity

description: Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.


floppase activity

description: Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.


lysophospholipid translocation

description: The movement of a lysophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.


name: xenobiotic detoxification by transmembrane export across the cell outer membrane

description: A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell through the outer membrane.


aminophospholipid translocation

description: The movement of an aminophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.


lipopolysaccharide transfer activity

description: Removes a lipopolysaccharide (LPS) from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane.


glycerophospholipid flippase activity

description: Catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.


name: lipopolysaccharide localization to cell outer membrane

description: A process in which a lipopolysaccharide is transported to the cell outer membrane.


diacylglyceride transfer activity

description: Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location.


sphingomyelin transfer activity

description: Removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane.


phosphatidylglycerol transfer activity

description: Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location.


cerebroside transfer activity

description: Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location.


description: Catalysis of the movement of phosphatidylethanolamine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.


phosphatidylserine transfer activity

description: Removes phosphatidylserine from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane.


triglyceride transfer activity

description: Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location.


phosphatidylcholine flippase activity

description: Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.


phosphatidylserine flippase activity

description: Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.


description: Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.


description: Catalysis of the movement of lysophosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.


glycosylceramide flippase activity

description: Catalysis of the movement of glycosylceramide from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Glycosylceramides are ceramides containing a functional group derived from a sugar.


export from cell

description: The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis.


lipid export from cell

description: The directed movement of a lipid from a cell, into the extracellular region.


lipid import into cell

description: The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.


cargo receptor ligand activity

description: The activity of a gene product that interacts with a cargo receptor and initiates endocytosis.


heme export from vacuole to cytoplasm

description: The directed movement of heme from inside the vacuole across the vacuolar membrane and into the cytosol.


name: P-type transmembrane transporter activity

description: Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.


ABC-type transporter activity

description: Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.


name: cyclic-GMP-AMP transmembrane transporter activity

description: Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other.


name: cyclic-GMP-AMP transmembrane import across plasma membrane

description: The directed movement of cyclic-GMP-AMP from outside of a cell, across the plasma membrane and into the cytosol.


TIS granule

description: A ribonucleoprotein granule located in the cytoplasm that is formed by the RNA-binding protein TIS11B and RNA molecules, enriched in membrane protein-encoding mRNAs with multiple AU-rich elements. TIS granules are reticular meshworks intertwined with the endoplasmic reticulum (ER).


GW body

description: A ribonucleoprotein granule located in the cytoplasm and the nucleus. GW-bodies minimally contain the Argonaute2 (Ago2) and TNRC6B proteins, together with specific target RNAs.


RNP body

description: A ribonucleoprotein granule located in the cytoplasm of bacteria, minimally containing the RNase E protein and RNA molecules. Bacterial RNP-bodies are similar to eukaryotic P-bodies and stress granules.


galectin lattice

description: A non-stoichiometric protein complex formed by several galectins crosslinking glycosylated ligands to form a dynamic lattice. The galectin lattice modulates receptor kinase signaling and the functionality of membrane receptors, by regulating the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids.


antibacterial innate immune response

description: An defense response against a bacteria mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.


decoy receptor complex

description: A receptor complex that recognizes, binds and sequesters a specific receptor ligand to prevent it from binding to its regular receptor. May be soluble or membrane bound.


antiviral innate immune response

description: A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.


immune receptor activity

description: Receiving a signal and transmitting it in a cell to initiate an immune response.


innate immune receptor activity

description: Receiving a signal and transmitting it in a cell to initiate an innate immune response.


psilocybin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of psilocybin, a psychotropic tryptamine-derived natural product.


name: 4-hydroxytryptamine 4-phosphate methyltransferase activity

description: Catalysis of the reaction: 2 S-adenosyl-L-methionine (SAM) + 4-hydroxytryptamine 4-phosphate (norbaeocystin) = 2 S-adenosyl-L-homocysteine + psilocybin.


tryptamine 4-monooxygenase activity

description: Catalysis of the reaction: tryptamine + reduced acceptor + O2 = 4-hydroxytryptamine + acceptor + H2O.


4-hydroxytryptamine kinase activity

description: Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H+.


metacyclogenesis

description: The morphological, biochemical and genetic changes that induce the differentiation of non-pathogenic parasites into pathogenic metacyclic parasites in the Trypanosomatidae species. The pathogenic parasites are known as metacyclic trypomastigotes in Trypanosoma and metacyclic promastigotes in Leishmania.


name: norsolorinic acid ketoreductase activity

description: Catalysis of the reaction: (1'S)-averantin + NADP+ = norsolorinic acid + NADPH.


ABC-type azole transporter activity

description: Enables the transfer of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other according to the reaction: ATP + H2O + azole(in) = ADP + phosphate + azole(out).


averantin hydroxylase activity

description: Catalyzes the reaction: (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O2 = (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H2O. Involved in aflatoxin biosynthesis.


description: Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD+ = 5'-oxoaverantin + NADH.


name: versiconal hemiacetal acetate esterase activity

description: Catalyzes the reactions: versiconal hemiacetal acetate + H2O = versiconal + acetate, as well as versiconol acetate + H2O = versiconol + acetate.


versicolorin B desaturase activity

description: Catalyzes the reaction: versicolorin B + NADPH + O2 = versicolorin A + NADP+ + 2 H2O. Uses heme-thiolate as a co-factor. Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.


aflatoxin B synthase activity

description: Catalyzes the reaction: 8-O-methylsterigmatocystin + 2 [reduced NADPH--hemoprotein reductase] + 2 O2 = aflatoxin B + 2 [oxidized NADPH--hemoprotein reductase] + H2O + methanol + CO2. Produces both aflatoxin B(1) and aflatoxin B(2).


name: effector-mediated suppression of host innate immune response

description: A process mediated by a molecule secreted by a symbiont that results in the suppression of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: effector-mediated perturbation of host innate immune response by symbiont

description: A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: spindle pole body-led chromosome movement during mitotic interphase

description: A microtubule-based process in which chromosomes migrate as a result of rapid spindle pole body (SPB) and centrosome oscillations during mitotic interphase.


name: L-alanine export across the plasma membrane

description: The directed movement of L-alanine from inside of a cell, across the plasma membrane and into the extracellular region.


name: L-alanine:proton antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out).


name: regulation of mRNA alternative polyadenylation

description: Any process that modulates the frequency, rate or extent of mRNA alternative polyadenylation.


name: positive regulation of mRNA alternative polyadenylation

description: Any process that activates or increases the frequency, rate or extent of mRNA alternative polyadenylation.


name: monoatomic cation:bicarbonate symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in).


name: zinc:bicarbonate symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) = zinc(in) + HCO3-(in).


description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) + HO3Se-(out) = zinc(in) + HCO3-(in) + HO3Se-(out).


description: Binding a substrate via a thioester at the terminal thiol of a covalentely linked phosphopantetheine prosthetic group and mediating protein-protein interactions with cognate enzymes for processing or offloading of the thiol-bound substrate.


name: effector-mediated modulation of host defenses by symbiont

description: A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: transcription regulator inhibitor activity

description: A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification.


name: intracellularly ATP-gated calcium channel activity

description: Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a ATP has been bound by the channel complex or one of its constituent parts.


name: effector-mediated modulation of host process by symbiont

description: A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host structure or process. The host is defined as the larger of the organisms involved in a symbiotic interaction.


heme import into cell

description: The directed movement of a heme from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.


endocytic heme import into cell

description: The directed movement into cell of externally available heme by receptor-mediated endocytosis.


name: effector-mediated suppression of host pattern-triggered immunity signaling

description: A process mediated by a molecule secreted by a symbiont that results in the suppression of a pattern-triggered immunity PTI signaling pathway. PTI signaling pathways are found in plants.


galactose import across plasma membrane

description: The directed movement of galactose from outside of a cell, across the plasma membrane and into the cytosol.


name: pathogen-associated molecular pattern receptor signaling pathway

description: The series of molecular signals initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. PAMP-triggered immunity PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.


name: positive regulation of mitotic sister chromatid biorientation

description: Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid biorientation, the mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed.


name: positive regulation of chromosome passenger complex localization to kinetochore

description: Any process that activates or increases the frequency, rate or extent of a chromosome passenger complex localization to kinetochore.


DNA-(abasic site) binding

description: Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base.


name: 5'-hydroxyl dinucleotide hydrolase activity

description: Catalysis of the hydrolysis of phosphodiester bonds in 5'OH-RNA according to the reaction 5'OH-RNA + H20 = 5'OH-NpN (dinucleotide) + 5'P-RNA.


name: regulation of protein localization to meiotic spindle pole body

description: Any process that modulates the frequency, rate or extent of protein localization to a meiotic spindle pole body.


name: positive regulation of protein localization to meiotic spindle pole body

description: Any process that increases the frequency, rate or extent of protein localization to a meiotic spindle pole body.


name: negative regulation of protein localization to meiotic spindle pole body

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to a meiotic spindle pole body.


protein stearoylation

description: The covalent attachment of a stearoyl group to an amino acid in a protein.


description: Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein].


description: Catalysis of the transfer of an oleoyl (systematic name, (9Z)-octadecenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein].


description: Catalysis of the transfer of an arachidonoyl (systematic name, (5Z,8Z,11Z,14Z)-eicosatetraenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: in the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein].


peroxide sensor activity

description: Binding to hydrogen peroxide (H2O2) and eliciting a change in the protein's activity in response to the intracellular level of that small molecule.


name: mitochondrion-plasma membrane adaptor activity

description: The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.


name: cytoskeleton-nuclear membrane anchor activity

description: The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane.


chromosome, telomeric repeat region

description: A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop.


fumigermin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of fumigermin, an alpha-pyrone secondary metabolite found in some species of fungi such as Aspergillus fumigatus.


cytokine precursor processing

description: The cleavage of a peptide bond in a precursor form of a cytokine, resulting in the mature (active) form of the cytokine.


name: signaling receptor ligand precursor processing

description: The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand.


name: centromere-nuclear envelope anchor activity

description: The binding activity of a molecule that brings together the centromeric region of a chromosome and the inner nuclear membrane by interacting with both the centromere/kinetochore complex and the nuclear membrane, in order to establish and maintain the centromere/kinetochore location.


protein targeting to Golgi apparatus

description: The process of targeting specific proteins to the Golgi apparatus. Usually requires an organelle-specific protein sequence motif or a protein modification (for example a palmitoylation).


counting factor complex

description: A secreted multiprotein complex composed of 4 proteins, regulating group size during aggregation in cooperative development. An example of this complex is found in Dictyostelium discoideum.


protein aggregate center

description: Reversible aggregate of misfolded proteins and chaperones formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.


protein aggregate center assembly

description: The reversible aggregation of misfolded proteins and chaperones, formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.


cytoplasm protein quality control

description: The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.


name: initial meiotic spindle pole body separation

description: The release of duplicated meiotic spindle pole bodies (SPBs).


protein demethylase activity

description: Catalysis of the removal of a methyl group from a protein.


response to Gram-positive bacterium

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-positive bacterium.


response to Gram-negative bacterium

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-negative bacterium.


description: The organization of chromatin into heterochromatin at the pericentric region of a chromosome.


chromatin-protein adaptor activity

description: The binding activity of a molecule that brings together a protein or a protein complex with a nucleosome, to establish or maintain the chromatin localization of the protein, or protein complex.


name: subnuclear spatial organization of silent mating-type cassette heterochromatin

description: The localization of silent mating-type cassette heterochromatin at a specific location in the nucleus.


name: iron-sulfur cluster export from the mitochondrion

description: The directed movement of iron sulfur clusters from inside the mitochondrion into the cytosol by crossing the inner mitochondrial membrane.


integrated stress response signaling

description: The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery.


HRI-mediated signaling

description: A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock.


GCN2-mediated signaling

description: A series of reactions in which a signal is passed on to downstream proteins within the cell via GCN2 (also known as EIF2AK4), an intracellular protein kinase that is activated by stress signals, such as amino acid starvation.


name: positive regulation of transepithelial migration of symbiont in host

description: Any process that activates or increases the frequency, rate or extent of transepithelial migration of symbiont in host.


cell cortex of non-growing cell tip

description: The region directly beneath the plasma membrane at the cell tip at which no growth takes place.


name: telomere-nuclear envelope anchor activity

description: The binding activity of a molecule that brings together the telomeric region of a chromosome and the inner nuclear membrane by interacting with both the telomere and the nuclear membrane, in order to establish and maintain the telomeric location.


name: mitochondrion-endoplasmic reticulum membrane tether activity

description: The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.


spindle pole body anchor activity

description: The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way.


name: ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase

description: A biosynthetic process that results in the formation of ergothioneine from histidine via a set of steps including the hercynylcysteine sulfoxide synthase reaction, which converts N-alpha,N-alpha,N-alpha-trimethyl-L-histidine directly to hercynylcysteine sulfoxide.


name: mitotic spindle pole body insertion into the nuclear envelope

description: A process in which the duplicated mitotic spindle pole body is inserted into a fenestra which opens in the nuclear envelope in early mitosis, and is subsequently tethered to the membrane.


name: ABC-type iron-sulfur cluster transporter activity

description: Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out).


iron sensor activity

description: Binding to and responding, e.g. by conformational change, to changes in the cellular level of iron.


kinetochore adaptor activity

description: The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way.


name: 5-aminolevulinic acid import across plasma membrane

description: The directed movement of 5-aminolevulinic acid from outside of a cell, across the plasma membrane and into the cytosol.


name: 5-aminolevulinic acid transmembrane transporter activity

description: Enables the transfer of 5-aminolevulinic acid from one side of a membrane to the other.


zinc ion sequestering activity

description: Binding to a zinc ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.


metal ion sequestering activity

description: Binding to a metal ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.


heme receptor activity

description: Binding specifically to heme to deliver it to a transport vesicle.


molecular template activity

description: The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence.


microtubule nucleator activity

description: The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly.


metal-dependent deubiquitinase activity

description: An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.


name: very long-chain fatty acid beta-oxidation

description: A fatty acid beta-oxidation pathway acting on a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).


migrasome

description: A vesicular organelle that forms on retraction fibers behind migrating cells and mediates the release of cytoplasmic contents during cell migration.


migracytosis

description: A cell migration-dependent mechanism for releasing cellular contents.


gamma-tubulin complex binding

description: Binding to a gamma-tubulin complex.


mannan polymerase II complex

description: A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p, Anp1p, Mnn10p, Mnn11p, and Hoc1p.


mannan polymerase I complex

description: A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the priming and elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p and Van1p.


description: Any process that stops, prevents, or reduces the frequency, rate or extent of negative regulation of mitotic spindle assembly checkpoint signaling.


regulation of reticulophagy

description: Any process that modulates the frequency, rate or extent of reticulophagy.


positive regulation of reticulophagy

description: Any process that increases the frequency, rate or extent of reticulophagy.


name: effector-mediated suppression of host salicylic acid-mediated innate immune signaling

description: A process mediated by a molecule secreted by a symbiont that results in the suppression of host salicylic acid-mediated innate immune signaling.


microlipophagy

description: Degradation of a lipid droplet by microautophagy.


regulation of microlipophagy

description: Any process that modulates the frequency, rate or extent of microlipophagy, the microautophagy-mediated direct internalization of lipid droplets into a lysosome-like vacuole during nutrient depletion.


name: endoplasmic reticulum-autophagosome adaptor activity

description: The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy.


name: granzyme-mediated programmed cell death signaling pathway

description: The series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells.


epithelium-like organization

description: The organization of a polarized cell layer during morphogenesis in protozoa; an example is found during culmination in D. discoideum, involving alpha and beta catenins.


mitotic nuclear bridge

description: A narrow constricted region of the nucleus that forms around the anaphase spindle during closed mitosis, and connects the main portions of the newly forming daughter nuclei.


mitotic nuclear bridge stalk

description: Either of the regions of a mitotic nuclear bridge proximal to the main portion of each daughter nucleus. The nuclear envelope in the stalk regions is depleted of nuclear pore complexes.


mitotic nuclear bridge midzone

description: The central region of a mitotic nuclear bridge, distal to the main portions of the daughter nuclei.


nuclear protein-containing complex

description: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.


mitotic nuclear bridge organization

description: A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the mitotic nuclear bridge during closed mitosis.


name: mitotic nuclear pore complex disassembly

description: The mitotic cell cycle process in which the controlled breakdown of the nuclear pores occurs during open or closed mitosis.


protein-RNA adaptor activity

description: The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way.


fusogenic activity

description: The activity of joining two lipid bilayers to form a single membrane.


GTPase-dependent fusogenic activity

description: A GTPase activity that mediates the joining two lipid bilayers to form a single membrane.


antipodal site

description: The pole of the kinetoplast associated with kinetoplast DNA replication. The antipodal sites flank the kinetoplast DNA disk and are positioned approximately 180 degrees apart. In Trypanosoma brucei and Crithidia fasciculata, minicircles are attached at antipodal sites and they contain enzymes that catalyse some of the later reactions in minicircle replication.


name: double membrane vesicle viral factory assembly

description: A process that results in the assembly of a cytoplasmic viral factory consisting of a double-membrane bound vesicle.


reciprocal homologous recombination

description: A DNA recombination process that results in the bidirectional exchange of genetic material between highly homologous DNA molecules.


bilobe structure assembly

description: The assembly and organization of a bilobe structure, a cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone).


CMG complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form the CMG complex, a protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. The process begins when additional proteins (e.g. Cdc45 and Sld3) join the loaded, inactive double MCM hexamer at replication origins, and ends when Mcm10 triggers the separation of the Mcm2-7 double hexamers, forming two active CMG complexes.


MCM complex loading

description: The protein localization process in which two MCM complexes become associated with chromatin at replication origins. MCM loading begins when origin-bound ORC and Cdc6 (Cdc18 in fission yeast) recruit one MCM2-7/Cdt1 complex to the origin, includes formation of a succession of intermediate complexes and ATP hydrolysis-dependent Mcm2-7 ring closure, and ends when two MCM hexamers fully encircle DNA, and are oriented head-to-head. The double hexamer is inactive for DNA unwinding. MCM loading takes place during G1 phase, and precedes CMG complex assembly.


name: symbiont-mediated suppression of host RNAi-mediated antiviral immune response

description: A process by which a symbiont inhibits or disrupts the host's RNAi-mediated antiviral immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: endoplasmic reticulum protein-containing complex

description: A protein complex that is part of an endoplasmic reticulum.


description: A protein-containing complex located intracellularly.


nuclear receptor corepressor activity

description: A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.


name: transcription regulator activator activity

description: A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification.


name: negative regulation of conjugation with zygote

description: A process that prevents a zygote from fusing an additional cell.


name: regulation of melanotic encapsulation of foreign target

description: Any process that modulates the frequency, rate or extent of melanotic encapsulation of foreign target.


name: negative regulation melanotic encapsulation of foreign target

description: Any process that stops, prevents or reduces the frequency, rate or extent of melanotic encapsulation of foreign target.


piRNA transcription

description: The cellular synthesis of Piwi-interacting RNA piRNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.


regulation of piRNA transcription

description: Any process that modulates the frequency, rate or extent of the synthesis of a piRNA.


name: positive regulation of piRNA transcription

description: Any process that increases the frequency, rate or extent of the synthesis of piRNA.


septin collar organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising the septin collar.


name: ATP-dependent protein disaggregase activity

description: An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates.


defense response to symbiont

description: Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host.


acquisition of seed longevity

description: The acquisition of seed longevity is the ordered series of events during seed development, that prevent embryo deterioration and ROS damage and thus contribute to seed viability over time or in response to adverse environmental conditions. These events include protective (e.g. production of glassy cytoplasm ) and repair (e.g. oxidative stress responses) processes.


name: envenomation resulting in blood agglutination in another organism

description: A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with specific proteins binding to cell-surface carbohydrates and causing calcium-dependent agglutination of blood cells in the bitten organism.


spore inner membrane

description: The membrane surrounding the spore core (endospore core) that separates it from its external environment.


description: Binding to and responding, e.g. by conformational change, to changes in the cellular level of phosphatidylinositol-4,5-bisphosphate.


TEAD-YAP complex

description: A transcription factor complex that is composed of the one DNA binding protein of the TEAD family and the transcriptional coactivator YAP.


description: Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains.


name: EGF-domain serine glucosyltransferase activity

description: Catalysis of the reaction: UDP-alpha-D-glucose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine.


name: EGF-domain serine xylosyltransferase activity

description: Catalyses the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine.


description: Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine.


histone reader activity

description: A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery.


membrane protein dislocase activity

description: The activity of removing a protein from a membrane, by binding to a transmembrane helical fragment of a tail-anchored protein and releasing it from the the hydrophobic region of one or both lipid bilayers. The reaction is driven by ATP hydrolysis.


name: extraction of mislocalized protein from membrane

description: The removal of a mislocalized protein from a cellular membrane.


name: extraction of mislocalized protein from ER membrane

description: The removal of a mislocalized protein from the endoplasmic reticulum (ER) membrane.


name: extraction of mislocalized protein from mitochondrial outer membrane

description: The removal of a mislocalized protein from the mitochondrial outer membrane.


name: transmembrane ascorbate ferrireductase activity

description: Oxidation of Fe(3+) to Fe(2+) on the outer side of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction.


vacuole fission

description: The division of a vacuole within a cell to form two or more separate vacuoles.


histone H3-containing nucleosome

description: A complex comprised of DNA wound around a multisubunit core and associated proteins containing the histone H3, which forms the primary packing unit of DNA into higher order structures.


name: transmembrane monodehydroascorbate reductase activity

description: Oxidation of monodehydroascorbate outside of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction.


ascorbate homeostasis

description: Any process involved in the maintenance of an internal steady state of ascorbate at the level of a cell.


name: mitochondrion autophagosome adaptor activity

description: The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy.


name: P-type monovalent copper transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu+(in) = ADP + phosphate + Cu+(out).


name: adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway

description: An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by extracellular cAMP binding to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process.


chromatin extrusion motor activity

description: A DNA translocase activity that folds chromosomal DNA and catalytically extends the newly formed loop, driven by ATP hydrolysis.


name: promoter-enhancer loop anchoring activity

description: Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop.


name: promoter-terminator loop anchoring activity

description: Bridging together a cis-regulatory element and a terminator DNA sequences on the chromatin, holding two loop anchors together, maintaining a chromatin loop.


chromatin loop anchoring activity

description: Bridging together two DNA loop anchors together, maintaining a chromatin loop.


chromatin looping

description: A chromatin organization process that starts with the loading of an extrusion motor (by an SMC family complex) onto the chromatin, followed by chromatin extrusion that stops at loop anchoring sites on the chromosome.


name: effector-mediated suppression of host defense response

description: A process mediated by a molecule secreted by a symbiont that results in the suppression of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.


nuclear envelope budding

description: The process by which large macromolecular complexes are budded through the inner nuclear membrane, into the perinuclear space, thus acquiring a membrane envelope. The enveloped particle fuses with the outer nuclear membrane and is released into the cytoplasm.


histone H3R8 methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to the arginine residue at position 8 of histone H3.


host apoplast

description: The apoplast region surrounding a host plant cell. Plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity

description: Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase.


MIM complex

description: A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. MIM constitutes the major integration site for alpha-helical embedded proteins. In yeast, consists oof Mim1 and Mim2.


TOM complex

description: A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. TOM transports beta-barrel precursors across the outer membrane and the sorting and assembly machinery (SAM complex) inserts them into the target membrane.


protein carrier chaperone

description: Binding to and carrying a protein between two different cellular components by moving along with the target protein.


lipoprotein carrier activity

description: Binding to and carrying a lipoprotein between two different cellular locations by moving along with the target lipoprotein.


name: mitotic nuclear bridge midzone membrane domain

description: A nuclear membrane part at the midzone of the mitotic nuclear bridge. The midzone forms a bulge that is enriched in nuclear pores that lack baskets.


nucleolar peripheral inclusion body

description: Inclusion bodies located at the nucleolar periphery where several nuclear factors are reversibly aggregated and sequestered during acute heat stress or starvation.


mycofactocin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of the coenzyme mycofactocin, a variably glycosylated small molecule electron pair carrier derived from the C-terminal valine-tyrosine dipeptide of the ribosomally translated precursor peptide MftA.


name: proton motive force-driven motor activity

description: A motor activity driven by an electrochemical proton gradient (proton-motive force). PMF-driven motors are used by bacterial flagella.


name: cysteine-type endopeptidase activator activity

description: Binds to and increases the activity of a cysteine-type endopeptidase.


phycocyanobilin biosynthetic process

description: The chemical reactions or pathway resulting in the formation of phycocyanobilin, which involves the oxidative cleavage of heme by a heme oxygenase (HO) to form biliverdin IX alpha. Biliverdin IX alpha is subsequently converted to phycocyanobilin by a ferredoxin-dependent oxidoreductase (PCYA).


RNA sequestering activity

description: Binding to a specific RNA molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.


DNA damage sensor activity

description: A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signaling response.


P-type manganese transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate.


description: The chemical reactions and pathways resulting in the formation of dihydroxy naphthalene (DHN)-melanin.


ATP-dependent citrate lyase complex

description: A protein complex that catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA.


iodotyrosine deiodinase activity

description: Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates.


name: ferric-chelate reductase (NADH) activity

description: Catalysis of the reaction: 2 Fe3+-siderophore + NAD+ + H+ -> 2 Fe2+-siderophore + NADH.


DNA strand exchange activator activity

description: Binds to and increases a DNA strand exchange activity.


DNA strand exchange inhibitor activity

description: Binds to and stops, prevents or reduces a DNA strand exchange activity.


type I pilus

description: A short filamentous structure on the surface of a bacterial cell distinguished from other pili by their D-mannose-sensitive agglutinatination of erythrocytes. In E. coli, type I pili consist of a short tip fibrillum made up of the adhesin protein (FimH) and two minor subunits (FimG and FimF) that is joined to the pilus rod, a homopolymer of ~1000 FimA subunits.


name: ER-to-endosome phospholipid transfer complex

description: Lipid transfer complex that is responsible for the non-vesicular transport of phospholipids, such as phosphatidylserine, from the endoplasmic reticulum to the endosome. It resides in the endosomal (acceptor) membrane and binds to specific lipids on the donor membrane at the ER-endosome contact site.


type I pilus assembly

description: The assembly from its constituent parts of a type I pilus.


EGAD pathway

description: The protein catabolic pathway which selectively extracts ER-resident membrane proteins exported to the Golgi and endosomes for degradation by cytosolic proteasomes. It begins with phosphorylation of the ER-resident membrane protein, which triggers export of the protein from the ER to the Golgi and endosomes, followed by polyubiquitination by the Dsc E3 ubiquitin ligase complex and extraction of the ubiquitinated target, and ends with proteasomal degradation.


opioid growth factor receptor activity

description: Combining with the opioid growth factor (OGF, met-enkephalin) and transmitting the signal across the nuclear membrane. Met-enkephalin is an endogenous opioid peptide that binds to opioid and opioid growth factor receptors, regulating tissue growth in a variety of cellular processes.


name: opioid growth factor receptor signaling pathway

description: The series of molecular signals generated as a consequence of an opioid growth factor receptor binding to its physiological ligand, opioid growth factor (OGF, met-enkephalin). The OGF-OGFr complex leads to the increase in the synthesis of the selective cyclin-dependent kinase (CDK) inhibitor proteins, p12 (POLD4) and p16 (CDKN2A).


name: ubiquitin-dependent protein catabolic process via the C-end degron rule pathway

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.


name: outward rectifier potassium channel inhibitor activity

description: Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel.


name: small conductance calcium-activated potassium channel inhibitor activity

description: Binds to and stops, prevents, or reduces the activity of a small conductance calcium-activated potassium channel.


all-trans-phytoene synthase activity

description: Catalysis of the reaction: 2 geranylgeranyl diphosphate -> all-trans-phytoene + 2 diphosphate.


name: aldehyde dehydrogenase (NAD+) inhibitor activity

description: Binds to and stops, prevents or reduces the activity of aldehyde dehydrogenase (NAD+).


canonical inflammasome complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form an inflammasome complex.


CARD8 inflammasome complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a CARD8 inflammasome complex.


CARD8 inflammasome complex

description: An inflammasome complex that consists of CARD8 and CASP1.


neutrophil dispersal

description: The movement of a neutrophil away from the site of wound or infection following its initial migration to the site.


copper import into the mitochondrion

description: The process in which copper is transported from the cytosol into the mitochondrial matrix.


name: small ribosomal subunit processing complex

description: A small heterodimeric protein complex that is required during early maturation of nascent 40S ribosomal subunits. The complex has endonuclease activity, it interacts with the small ribosomal subunit pre-rRNA and cleave it it to produce the mature 18S (or small ribosomal subunit) rRNA. In S. cerevisiae it is composed of Rcl1p and Bms1p.


name: positive regulation of pyroptotic inflammatory response

description: Any process that increases the frequency, rate or extent of a pyroptotic inflammatory response.


name: catalytic activity, acting on a nucleic acid

description: Catalytic activity that acts to modify a nucleic acid.


name: mitotic spindle formation (spindle phase two)

description: The spindle organization process in which the spindle is maintained at a constant length during mitotic metaphase.


name: meiotic spindle formation (spindle phase two)

description: The spindle organization process in which the spindle is maintained at a constant length during meiotic metaphase.


name: hydroxymethylglutaryl-CoA reductase (NADH) activity

description: Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.


neutrophil extracellular trap

description: Extracellular microbicidal structure composed of nuclear chromatin, histones and granular antimicrobial proteins. Histones and several neutrophil granule proteins associated with the DNA framework damage entrapped microorganisms.


neutrophic extracellular trap formation

description: The aggregation, arrangement and bonding together of a set of components to form a neutrophil extracellular trap, a network of extracellular fibers primarily composed of DNA from neutrophils, which bind and neutralizes pathogens.


name: negative regulation of pre-B cell receptor expression

description: Any process that stops, prevents or reduces the frequency, rate or extent of the process leading up to expression of the pre-B cell receptor on the surface of pre-B cells.


name: P450-containing electron transport chain

description: A electron transport chain in which one or more electron carriers operate to transfer electrons from donors to a cytochrome P450 protein or domain. Electron carriers operating in this chain include FAD-containing flavoproteins or domains, FMN domains, ferredoxins and cytochrome b5. The reduced cytochrome P450 functions as the terminal oxidase and participates in a wide range of biochemical pathways.


name: positive regulation of cell cycle switching, mitotic to meiotic cell cycle

description: Any process that activates or increases the frequency, rate or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division.


name: symbiont-mediated cell-to-cell migration by invasive hypha

description: The directional movement of a hyphal filament from one host cell to another. This process involves the clearance of plant-derived plasmodesmal occlusion materials, cytoskeleton based constriction of invasive hypha to traverse plasmodesmata. Septins and F-actin are reorganized into an hourglass shape at the point of maximum hyphal constriction.


name: radial glia-guided pyramidal neuron migration

description: The radial migration of a pyramidal neuron along radial glial cells.


futile creatine cycle

description: The phosphorylation and dephosphorylation of creatine in a futile cycle, which dissipates the high energy charge of phosphocreatine as heat without performing any mechanical or chemical work. The futile creatine cycle takes place in thermogenic fat cells and is part of adaptive thermogenesis.


pyripyropene A biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pyripyropene A.


tryprostatin A biosynthetic process

description: The chemical reactions and pathways resulting in the formation of tryprostatin A.


description: Binds to and increases the activity of an endodeoxyribonuclease.


ATP-dependent activity

description: A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.


name: ATP-dependent chromatin remodeler activity

description: An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.


cytoskeletal motor regulator activity

description: Binds to and modulates the activity of a motor protein.


cytoskeletal motor activator activity

description: Binds to and increases the activity of a motor protein.


cytoskeletal motor inhibitor activity

description: Binds to and stops, prevents, or reduces the activity of a motor protein.


ATP-dependent protein folding chaperone

description: Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.


ATP-dependent FeS chaperone activity

description: Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis.


name: ATP-dependent DNA damage sensor activity

description: A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis.


name: ATP-dependent H3-H4 histone complex chaperone activity

description: A histone chaperone that carries a H3-H4 histone complex, driven by ATP hydrolysis.


annealing activity

description: An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule.


regulation of oxytocin production

description: Any process that modulates the frequency, rate, or extent of production of oxytocin.


name: positive regulation of oxytocin production

description: Any process that activates or increases the frequency, rate or extent of production of oxytocin.


name: negative regulation of oxytocin production

description: Any process that stops, prevents, or reduces the rate of production of oxytocin.


cohesin unloader activity

description: Facilitating a conformational change to unload a cohesin complex from sister chromatids.


ADA complex

description: A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and H2B. In budding yeast shares the histone acetylation (HAT) module of ADA2-GCN5-NGG1-SGF29 with the related SAGA complex.


ATAC complex

description: A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation.


name: transcription elongation-coupled chromatin remodeling

description: A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation.


name: ATP-dependent histone chaperone activity

description: Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome, driven by ATP hydrolysis.


oscillatory cAMP signaling

description: Fluctuation in the extracellular cAMP levels due to the alternate activation of adenylate cyclase, which produces cAMP, and phosphodiesterase, which degrades it. Occurs in Dictyostelium during early sorocarp development. Oscillation in signaling result is directional chemotaxis of cells towards the center of the aggregate.


molecular function activator activity

description: A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target.


molecular function inhibitor activity

description: A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target.


ABC-type sodium transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na(in) = ADP + phosphate + Na(out).


name: histone H3K36me/H3K36me2 demethylase activity

description: Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


name: histone H3K36me2/H3K36me3 demethylase activity

description: Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


name: FAD-dependent H3K4me/H3K4me3 demethylase activity

description: Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction.


name: histone H3K9me/H3K9me2 demethylase activity

description: Catalysis of the removal of a methyl group from a di or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


name: histone H3K9me2/H3K9me3 demethylase activity

description: Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


name: FAD-dependent histone H3K9me/H3K9me2 demethylase activity

description: Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction.


name: dihydropyrimidine dehydrogenase (NAD+) complex

description: A heteromultimeric complex capable of dihydropyrimidine dehydrogenase (NAD+); in E. coli, composed of PreA and PreT.


RNA folding chaperone

description: Binding to an RNA or an RNA-containing complex to assist the folding process.


name: very long-chain fatty acid omega-hydroxylase activity

description: Catalysis of the reaction: an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an omega-hydroxy-very-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.


molecular condensate scaffold activity

description: Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate.


non-membrane-bounded organelle assembly

description: The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle.


description: Catalysis of the reaction: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol.


name: attachment of telomeric heterochromatin to nuclear envelope

description: The process in which physical connections are formed between sub-telomeric heterochromatin and the nuclear envelope facilitating bouquet formation.


cyclic GMP-AMP synthase activity

description: Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP.


3',2'-cyclic GMP-AMP synthase activity

description: Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(2'-5') (cyclic 3',2' GAMP).


3',3'-cyclic GMP-AMP synthase activity

description: Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(3'-5') (cyclic 3',3' GAMP).


cyclic GMP-AMP binding

description: Binding to cyclic GMP-AMP (cGAMP) nucleotide.


3',3'-cyclic GMP-AMP binding

description: Binding to 3',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 3',5' linkages.


3',2'-cyclic GMP-AMP binding

description: Binding to 3',2' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 2',5' linkages.


name: protein-containing complex localization to centriolar satellite

description: A protein-containing complex localization by which the complex is transported to, or maintained in, the centriolar satellite.