lymphotoxin A production

description: The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A.


regulation of chemokine production

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that modulates the frequency, rate, or extent of chemokine production.


name: regulation of connective tissue growth factor production

description: Any process that modulates the frequency, rate, or extent of connective tissue growth factor production.


regulation of fractalkine production

description: Any process that modulates the frequency, rate, or extent of fractalkine production.


name: regulation of granulocyte macrophage colony-stimulating factor production

description: Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


name: regulation of hepatocyte growth factor production

description: Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production.


name: regulation of interferon-alpha production

description: Any process that modulates the frequency, rate, or extent of interferon-alpha production.


name: regulation of interferon-beta production

description: Any process that modulates the frequency, rate, or extent of interferon-beta production.


name: regulation of type II interferon production

description: Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.


name: regulation of interleukin-1 alpha production

description: Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production.


name: regulation of interleukin-1 beta production

description: Any process that modulates the frequency, rate, or extent of interleukin-1 beta production.


regulation of interleukin-1 production

description: Any process that modulates the frequency, rate, or extent of interleukin-1 production.


regulation of interleukin-10 production

description: Any process that modulates the frequency, rate, or extent of interleukin-10 production.


regulation of interleukin-11 production

description: Any process that modulates the frequency, rate, or extent of interleukin-11 production.


regulation of interleukin-12 production

description: Any process that modulates the frequency, rate, or extent of interleukin-12 production.


regulation of interleukin-13 production

description: Any process that modulates the frequency, rate, or extent of interleukin-13 production.


regulation of interleukin-15 production

description: Any process that modulates the frequency, rate, or extent of interleukin-15 production.


regulation of interleukin-16 production

description: Any process that modulates the frequency, rate, or extent of interleukin-16 production.


regulation of interleukin-17 production

description: Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.


regulation of interleukin-18 production

description: Any process that modulates the frequency, rate, or extent of interleukin-18 production.


regulation of interleukin-19 production

description: Any process that modulates the frequency, rate, or extent of interleukin-19 production.


regulation of interleukin-2 production

description: Any process that modulates the frequency, rate, or extent of interleukin-2 production.


regulation of interleukin-20 production

description: Any process that modulates the frequency, rate, or extent of interleukin-20 production.


regulation of interleukin-21 production

description: Any process that modulates the frequency, rate, or extent of interleukin-21 production.


regulation of interleukin-22 production

description: Any process that modulates the frequency, rate, or extent of interleukin-22 production.


regulation of interleukin-23 production

description: Any process that modulates the frequency, rate, or extent of interleukin-23 production.


regulation of interleukin-24 production

description: Any process that modulates the frequency, rate, or extent of interleukin-24 production.


regulation of interleukin-25 production

description: Any process that modulates the frequency, rate, or extent of interleukin-25 production.


regulation of interleukin-26 production

description: Any process that modulates the frequency, rate, or extent of interleukin-26 production.


regulation of interleukin-27 production

description: Any process that modulates the frequency, rate, or extent of interleukin-27 production.


regulation of interleukin-3 production

description: Any process that modulates the frequency, rate, or extent of interleukin-3 production.


regulation of interleukin-4 production

description: Any process that modulates the frequency, rate, or extent of interleukin-4 production.


regulation of interleukin-5 production

description: Any process that modulates the frequency, rate, or extent of interleukin-5 production.


regulation of interleukin-6 production

description: Any process that modulates the frequency, rate, or extent of interleukin-6 production.


regulation of interleukin-7 production

description: Any process that modulates the frequency, rate, or extent of interleukin-7 production.


regulation of interleukin-8 production

description: Any process that modulates the frequency, rate, or extent of interleukin-8 production.


regulation of interleukin-9 production

description: Any process that modulates the frequency, rate, or extent of interleukin-9 production.


regulation of TRAIL production

description: Any process that modulates the frequency, rate, or extent of TRAIL production.


name: regulation of tumor necrosis factor production

description: Any process that modulates the frequency, rate or extent of tumor necrosis factor production.


regulation of lymphotoxin A production

description: Any process that modulates the frequency, rate, or extent of lymphotoxin A production.


name: negative regulation of chemokine production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production.


name: negative regulation of connective tissue growth factor production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production.


name: negative regulation of fractalkine production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production.


name: negative regulation of granulocyte macrophage colony-stimulating factor production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


name: negative regulation of hepatocyte growth factor production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production.


name: negative regulation of interferon-alpha production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production.


name: negative regulation of interferon-beta production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production.


name: negative regulation of type II interferon production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.


name: negative regulation of interleukin-1 alpha production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production.


name: negative regulation of interleukin-1 beta production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.


name: negative regulation of interleukin-1 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production.


name: negative regulation of interleukin-10 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.


name: negative regulation of interleukin-11 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production.


name: negative regulation of interleukin-12 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.


name: negative regulation of interleukin-13 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production.


name: negative regulation of interleukin-15 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production.


name: negative regulation of interleukin-16 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production.


name: negative regulation of interleukin-17 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.


name: negative regulation of interleukin-18 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production.


name: negative regulation of interleukin-19 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production.


name: negative regulation of interleukin-2 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.


name: negative regulation of interleukin-20 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production.


name: negative regulation of interleukin-21 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production.


name: negative regulation of interleukin-22 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production.


name: negative regulation of interleukin-23 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production.


name: negative regulation of interleukin-24 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production.


name: negative regulation of interleukin-25 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production.


name: negative regulation of interleukin-26 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production.


name: negative regulation of interleukin-27 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production.


name: negative regulation of interleukin-3 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production.


name: negative regulation of interleukin-4 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.


name: negative regulation of interleukin-5 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production.


name: negative regulation of interleukin-6 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.


name: negative regulation of interleukin-7 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production.


name: negative regulation of interleukin-8 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production.


name: negative regulation of interleukin-9 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production.


negative regulation of TRAIL production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production.


name: negative regulation of tumor necrosis factor production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.


name: negative regulation of lymphotoxin A production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production.


name: positive regulation of chemokine production

description: Any process that activates or increases the frequency, rate, or extent of chemokine production.


name: positive regulation of connective tissue growth factor production

description: Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production.


name: positive regulation of fractalkine production

description: Any process that activates or increases the frequency, rate, or extent of fractalkine production.


name: positive regulation of granulocyte macrophage colony-stimulating factor production

description: Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


name: positive regulation of hepatocyte growth factor production

description: Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production.


name: positive regulation of interferon-alpha production

description: Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.


name: positive regulation of interferon-beta production

description: Any process that activates or increases the frequency, rate, or extent of interferon-beta production.


name: positive regulation of type II interferon production

description: Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.


name: positive regulation of interleukin-1 alpha production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production.


name: positive regulation of interleukin-1 beta production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production.


name: positive regulation of interleukin-1 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-1 production.


name: positive regulation of interleukin-10 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.


name: positive regulation of interleukin-11 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-11 production.


name: positive regulation of interleukin-12 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.


name: positive regulation of interleukin-13 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.


name: positive regulation of interleukin-15 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-15 production.


name: positive regulation of interleukin-16 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-16 production.


name: positive regulation of interleukin-17 production

description: Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.


name: positive regulation of interleukin-18 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.


name: positive regulation of interleukin-19 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-19 production.


name: positive regulation of interleukin-2 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.


name: positive regulation of interleukin-20 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-20 production.


name: positive regulation of interleukin-21 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-21 production.


name: positive regulation of interleukin-22 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-22 production.


name: positive regulation of interleukin-23 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-23 production.


name: positive regulation of interleukin-24 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-24 production.


name: positive regulation of interleukin-25 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-25 production.


name: positive regulation of interleukin-26 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-26 production.


name: positive regulation of interleukin-27 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-27 production.


name: positive regulation of interleukin-3 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-3 production.


name: positive regulation of interleukin-4 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.


name: positive regulation of interleukin-5 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-5 production.


name: positive regulation of interleukin-6 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.


name: positive regulation of interleukin-7 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-7 production.


name: positive regulation of interleukin-8 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.


name: positive regulation of interleukin-9 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-9 production.


positive regulation of TRAIL production

description: Any process that activates or increases the frequency, rate, or extent of TRAIL production.


name: positive regulation of tumor necrosis factor production

description: Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.


name: positive regulation of lymphotoxin A production

description: Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production.


mast cell cytokine production

description: Any process that contributes to cytokine production by a mast cell.


name: regulation of mast cell cytokine production

description: Any process that modulates the frequency, rate, or extent of mast cell cytokine production.


name: negative regulation of mast cell cytokine production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production.


name: positive regulation of mast cell cytokine production

description: Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production.


NHE3/E3KARP/ACTN4 complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments.


copper-dependent protein binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to a protein or protein complex, in the presence of copper.


regulation of monooxygenase activity

description: Any process that modulates the activity of a monooxygenase.


name: negative regulation of monooxygenase activity

description: Any process that stops or reduces the activity of a monooxygenase.


name: positive regulation of monooxygenase activity

description: Any process that activates or increases the activity of a monooxygenase.


regulation of tyrosinase activity

description: Any process that modulates the activity of a tyrosinase enzyme.


name: negative regulation of tyrosinase activity

description: Any process that stops or reduces the activity of a tyrosinase enzyme.


name: positive regulation of tyrosinase activity

description: Any process that activates or increases the activity of a tyrosinase enzyme monophenol oxygenase.


RNA biosynthetic process

description: The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.


name: piccolo histone acetyltransferase complex

description: A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p.


P-type cobalt transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Co2+(out) = ADP + phosphate + Co2+(in).


name: negative regulation of ATP-dependent activity

description: Any process that stops or reduces the rate of an ATP-dependent activity.


name: positive regulation of ATP-dependent activity

description: Any process that activates or increases the rate of an ATP-dependent activity.


bile acid secretion

description: The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.


super elongation complex

description: A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae.


name: regulation of DNA-templated transcription elongation

description: Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.


name: negative regulation of DNA-templated transcription, elongation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.


name: positive regulation of DNA-templated transcription, elongation

description: Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.


monocarboxylic acid metabolic process

description: The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).


name: saturated monocarboxylic acid metabolic process

description: The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds.


name: unsaturated monocarboxylic acid metabolic process

description: The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds.


ribosome disassembly

description: The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.


lead ion binding

description: Binding to lead (Pb) ions.


name: negative regulation of CREB transcription factor activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB.


name: positive regulation of CREB transcription factor activity

description: Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.


GTPase activating protein binding

description: Binding to a GTPase activating protein.


heterotrimeric G-protein binding

description: Binding to a heterotrimeric G-protein.


uropod organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated.


SMN complex

description: A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus.


Swi5-Sfr1 complex

description: A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces).


name: low-density lipoprotein receptor particle metabolic process

description: The chemical reactions and pathways involving low-density lipoprotein receptors.


receptor catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.


name: low-density lipoprotein particle receptor catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.


name: regulation of low-density lipoprotein particle receptor catabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors.


name: negative regulation of low-density lipoprotein particle receptor catabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors.


name: positive regulation of low-density lipoprotein particle receptor catabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors.


name: carboxy-terminal domain protein kinase complex

description: A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5.


DNA ligase IV complex

description: A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p.


lacrimal gland development

description: The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye.


neuronal cell body membrane

description: The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.


sterol response element binding

description: Binding to a sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism.


name: negative regulation of epinephrine secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine.


name: positive regulation of epinephrine secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine.


name: tumor necrosis factor receptor superfamily binding

description: Binding to a member of the tumor necrosis factor receptor superfamily.


name: regulation of natural killer cell activation

description: Any process that modulates the frequency, rate or extent of natural killer cell activation.


name: negative regulation of natural killer cell activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation.


name: positive regulation of natural killer cell activation

description: Any process that activates or increases the frequency, rate or extent of natural killer cell activation.


name: regulation of natural killer cell proliferation

description: Any process that modulates the frequency, rate or extent of natural killer cell proliferation.


name: negative regulation of natural killer cell proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation.


name: positive regulation of natural killer cell proliferation

description: Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation.


name: regulation of natural killer cell proliferation involved in immune response

description: Any process that modulates the frequency, rate or extent of natural killer cell proliferation as part of an immune response.


name: negative regulation of natural killer cell proliferation involved in immune response

description: Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation as part of an immune response.


name: positive regulation of natural killer cell proliferation involved in immune response

description: Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation as part of an immune response.


name: regulation of natural killer cell differentiation

description: Any process that modulates the frequency, rate or extent of natural killer cell differentiation.


name: negative regulation of natural killer cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation.


name: positive regulation of natural killer cell differentiation

description: Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation.


name: regulation of natural killer cell differentiation involved in immune response

description: Any process that modulates the frequency, rate or extent of natural killer cell differentiation as part of an immune response.


name: negative regulation of natural killer cell differentiation involved in immune response

description: Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response.


name: positive regulation of natural killer cell differentiation involved in immune response

description: Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation as part of an immune response.


name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

description: Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells.


name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells.


name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

description: Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells.


name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

description: Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response.


name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

description: Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response.


name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

description: Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response.


glomerulus development

description: The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.


name: glomerular basement membrane development

description: The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration.


distributive segregation

description: The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a backup mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally.


name: plasma membrane bounded cell projection cytoplasm

description: All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection.


dendrite cytoplasm

description: All of the contents of a dendrite, excluding the surrounding plasma membrane.


calcitonin binding

description: Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid.


hydroperoxide reductase activity

description: Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol.


regulation of cellular pH reduction

description: Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell.


name: negative regulation of cellular pH reduction

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell.


name: positive regulation of cellular pH reduction

description: Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell.


ERMES complex

description: A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles.


D-xylose reductase (NADPH) activity

description: Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+.


L-arabinose reductase (NADPH) activity

description: Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+.


response to insulin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.


cellular response to insulin stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.


cellular response to hormone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.


regulation of karyogamy

description: Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion.


name: regulation of stress-activated MAPK cascade

description: Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.


name: negative regulation of stress-activated MAPK cascade

description: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.


name: positive regulation of stress-activated MAPK cascade

description: Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.


regulation of DNA endoreduplication

description: Any process that modulates the frequency, rate or extent of DNA endoreduplication.


name: negative regulation of DNA endoreduplication

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication.


name: positive regulation of DNA endoreduplication

description: Any process that activates or increases the frequency, rate or extent of DNA endoreduplication.


name: regulation of establishment or maintenance of cell polarity

description: Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.


regulation of localization

description: Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.


regulation of protein localization

description: Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.


name: regulation of polysaccharide metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides.


regulation of chitin metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin.


name: regulation of chitin biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chitin.


name: regulation of polysaccharide biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.


regulation of microtubule-based process

description: Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.


regulation of spindle elongation

description: Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the spindle.


name: regulation of mitotic spindle elongation

description: Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle.


name: regulation of vacuole fusion, non-autophagic

description: Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole.


regulation of organic acid transport

description: Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: negative regulation of organic acid transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: positive regulation of organic acid transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


palmitoyl-CoA 9-desaturase activity

description: Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O.


name: negative regulation of viral transcription

description: Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription.


neurotrophin production

description: The appearance of a neurotrophin due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. A neurotrophin is any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.


regulation of neurotrophin production

description: Any process that modulates the frequency, rate, or extent of production of a neurotrophin.


name: negative regulation of neurotrophin production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin.


name: positive regulation of neurotrophin production

description: Any process that activates or increases the frequency, rate, or extent of production of a neurotrophin.


nerve growth factor production

description: The appearance of nerve growth factor (NGF) due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels.


name: regulation of nerve growth factor production

description: Any process that modulates the frequency, rate, or extent of production of nerve growth factor (NGF).


name: negative regulation of nerve growth factor production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of nerve growth factor (NGF).


name: transforming growth factor beta1 production

description: The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


name: transforming growth factor beta2 production

description: The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


name: transforming growth factor beta3 production

description: The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


name: regulation of transforming growth factor beta1 production

description: Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta1.


name: regulation of transforming growth factor beta2 production

description: Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2.


name: regulation of transforming growth factor beta3 production

description: Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta3.


name: negative regulation of transforming growth factor beta1 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1.


name: negative regulation of transforming growth factor beta2 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2.


name: negative regulation of transforming growth factor beta3 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3.


name: positive regulation of transforming growth factor beta1 production

description: Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1.


name: positive regulation of transforming growth factor beta2 production

description: Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2.


name: positive regulation of transforming growth factor beta3 production

description: Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3.


polyamine acetylation

description: The modification of polyamines by addition of acetyl groups.


spermidine acetylation

description: The modification of spermidine by addition of acetyl groups.


spermine acetylation

description: The modification of spermine by addition of acetyl groups.


putrescine acetylation

description: The modification of putrescine by addition of acetyl groups.


sarcosine oxidase complex

description: A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity.


circadian regulation of gene expression

description: Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.


name: organic phosphonate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Synthesis of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.


activin receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: regulation of activin receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway.


name: negative regulation of activin receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway.


name: positive regulation of activin receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway.


name: regulation of superoxide anion generation

description: Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell.


name: negative regulation of superoxide anion generation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell.


name: positive regulation of superoxide anion generation

description: Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.


name: histone H3K56 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56).


name: negative regulation of astral microtubule depolymerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of astral microtubules.


SREBP signaling pathway

description: The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.


sterol binding

description: Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.


sterol sensor activity

description: Binding to and responding, e.g. by conformational change, to changes in the cellular level of a sterol.


SREBP-SCAP complex

description: A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed.


SREBP-SCAP-Insig complex

description: A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane.


name: negative regulation of translation in response to oxidative stress

description: Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


name: positive regulation of translation in response to oxidative stress

description: Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


secretion by cell

description: The controlled release of a substance by a cell.


secretion by tissue

description: The controlled release of a substance by a tissue.


name: inositol tetrakisphosphate 2-kinase activity

description: Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP.


mononuclear cell proliferation

description: The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.


name: regulation of mononuclear cell proliferation

description: Any process that modulates the frequency, rate or extent of mononuclear cell proliferation.


name: negative regulation of mononuclear cell proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation.


name: positive regulation of mononuclear cell proliferation

description: Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.


name: regulation of alpha-glucan metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-glucans.


name: regulation of alpha-glucan biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of alpha-glucans.


name: regulation of beta-glucan metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-glucans.


name: regulation of beta-glucan biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of beta-glucans.


name: regulation of (1->3)-beta-D-glucan metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-beta-D-glucans.


name: regulation of (1->3)-beta-D-glucan biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans.


regulation of cytokinetic process

description: Any process that modulates the frequency, rate or extent of a cytokinetic process.


regulation of division septum assembly

description: Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.


name: regulation of actin cytoskeleton organization

description: Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.


name: inositol trisphosphate metabolic process

description: The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.


inositol phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.


name: inositol trisphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.


name: regulation of inositol trisphosphate biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.


name: negative regulation of inositol trisphosphate biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.


name: positive regulation of inositol trisphosphate biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.


collagen metabolic process

description: The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).


collagen biosynthetic process

description: The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).


name: regulation of collagen biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.


name: negative regulation of collagen biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.


name: positive regulation of collagen biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.


name: positive regulation of transcription elongation by RNA polymerase II

description: Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.


endosomal scaffold complex

description: A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling.


name: regulation of actin filament-based process

description: Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton.


regulation of muscle filament sliding

description: Any process that modulates the frequency, rate or extent of muscle filament sliding.


name: regulation of muscle filament sliding speed

description: Any process that modulates the velocity of muscle filament sliding.


name: amino acid export across plasma membrane

description: The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region.


name: amino acid transmembrane export from vacuole

description: The directed movement of amino acids out of the vacuole, across the vacuolar membrane.


name: amino acid transmembrane import into vacuole

description: The directed movement of amino acids into the vacuole across the vacuolar membrane.


name: release of matrix enzymes from mitochondria

description: The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process.


membrane insertase activity

description: Binds transmembrane domain-containing proteins and mediates their integration into a membrane.


name: protein insertion into membrane from inner side

description: The process in which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side.


name: protein insertion into mitochondrial inner membrane from matrix

description: The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix.


keratinocyte activation

description: A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines.


name: mitochondrial respiratory chain complex I assembly

description: The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.


myosin filament

description: A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament.


name: kainate selective glutamate receptor complex

description: An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits.


protein-containing complex disassembly

description: The disaggregation of a protein-containing macromolecular complex into its constituent components.


description: The disaggregation of a protein-carbohydrate complex into its constituent components.


protein-DNA complex disassembly

description: The disaggregation of a protein-DNA complex into its constituent components.


protein-lipid complex disassembly

description: The disaggregation of a protein-lipid complex into its constituent components.


protein-RNA complex disassembly

description: The disaggregation of a protein-RNA complex into its constituent components.


name: cellular anatomical entity morphogenesis

description: The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system.


protein-containing complex

description: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.


protein-carbohydrate complex

description: A macromolecular complex containing separate protein and carbohydrate molecules. Separate in this context means not covalently bound to each other.


protein-DNA complex

description: A macromolecular complex containing both protein and DNA molecules.


protein-lipid complex

description: A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other.


name: regulation of fungal-type cell wall biogenesis

description: Any process that modulates the process in which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin.


Bcl3-Bcl10 complex

description: A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus.


Fc receptor complex

description: A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin.


Fc-epsilon receptor I complex

description: A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE.


Fc-alpha receptor I complex

description: A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA.


Fc-gamma receptor I complex

description: A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG.


Fc-gamma receptor III complex

description: A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG.


muscle cell proliferation

description: The expansion of a muscle cell population by cell division.


regulation of mast cell activation

description: Any process that modulates the frequency, rate, or extent of mast cell activation.


name: negative regulation of mast cell activation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation.


name: positive regulation of mast cell activation

description: Any process that activates or increases the frequency, rate, or extent of mast cell activation.


name: regulation of mast cell activation involved in immune response

description: Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response.


name: negative regulation of mast cell activation involved in immune response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response.


name: positive regulation of mast cell activation involved in immune response

description: Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response.


nucleomorph

description: A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively.


paranodal junction

description: A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.


perinuclear theca

description: A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins.


porosome

description: A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles.


tetrapyrrole metabolic process

description: The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.


tetrapyrrole biosynthetic process

description: The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.


tetrapyrrole catabolic process

description: The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.


rhoptry membrane

description: The lipid bilayer surrounding a rhoptry.


sarcoplasmic reticulum membrane

description: The lipid bilayer surrounding the sarcoplasmic reticulum.


sarcoplasmic reticulum lumen

description: The volume enclosed by the membranes of the sarcoplasmic reticulum.


description: Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH.


cyclopentanol metabolic process

description: The chemical reactions and pathways involving cyclopentanol.


cyclopentanol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cyclopentanol.


cyclopentanol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of cyclopentanol.


mast cell homeostasis

description: The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.


mast cell apoptotic process

description: Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.


name: regulation of mast cell apoptotic process

description: Any process that modulates the frequency, rate, or extent of mast cell apoptotic process.


name: negative regulation of mast cell apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process.


name: positive regulation of mast cell apoptotic process

description: Any process that activates or increases the frequency, rate, or extent of mast cell apoptotic process.


myeloid cell apoptotic process

description: Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.


name: regulation of neutrophil apoptotic process

description: Any process that modulates the frequency, rate, or extent of neutrophil apoptotic process.


name: negative regulation of neutrophil apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process.


name: positive regulation of neutrophil apoptotic process

description: Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process.


name: regulation of myeloid cell apoptotic process

description: Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process.


name: negative regulation of myeloid cell apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process.


name: positive regulation of myeloid cell apoptotic process

description: Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process.


macromolecule localization

description: Any process in which a macromolecule is transported to, or maintained in, a specific location.


polysaccharide localization

description: Any process in which a polysaccharide is transported to, or maintained in, a specific location.


bitter taste receptor activity

description: Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste.


name: ionotropic salty taste receptor activity

description: Enables the transmembrane transfer of an ion by a channel that opens when a soluble salty compound has been bound by the channel complex or one of its constituent parts.


sour taste receptor activity

description: Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste.


sweet taste receptor activity

description: Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste.


umami taste receptor activity

description: Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates.


regulation of organelle organization

description: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.


regulation of chromosome organization

description: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.


name: regulation of sister chromatid segregation

description: Any process that modulates the frequency, rate or extent of sister chromatid segregation.


name: negative regulation of sister chromatid segregation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation.


name: regulation of mitotic sister chromatid segregation

description: Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis.


name: negative regulation of mitotic sister chromatid segregation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis.


clavulanic acid metabolic process

description: The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.


clavulanic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.


aminophosphonate metabolic process

description: The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group.


cyanoamino acid metabolic process

description: The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group.


D-glutamine metabolic process

description: The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid.


D-glutamate metabolic process

description: The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid.


D-arginine metabolic process

description: The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid.


D-ornithine metabolic process

description: The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid.


directional locomotion

description: Self-propelled movement of a cell or organism from one location to another along an axis.


cellular pigmentation

description: The deposition or aggregation of coloring matter in a cell.


ocellus pigmentation

description: The deposition or aggregation of coloring matter in an ocellus, a minute simple eye found in many invertebrates.


DNA recombinase mediator complex

description: A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange.


Rad51B-Rad51C-Rad51D-XRCC2 complex

description: A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof.


XRCC2-RAD51D complex

description: A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast.


Rad51C-XRCC3 complex

description: A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof.


Rad51B-Rad51C complex

description: A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof.


macrolide metabolic process

description: The chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria.


macrolide biosynthetic process

description: The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria.


ansamycin metabolic process

description: The chemical reactions and pathways involving ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity.


ansamycin biosynthetic process

description: The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity.


vancomycin metabolic process

description: The chemical reactions and pathways involving vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria.


vancomycin biosynthetic process

description: The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria.


pinene metabolic process

description: The chemical reactions and pathways involving the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane.


pinene catabolic process

description: The chemical reactions and pathways leading to the breakdown of the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane.


name: isoquinoline alkaloid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin.


isoquinoline alkaloid metabolic process

description: The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin.


T cell differentiation in thymus

description: The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.


extrathymic T cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus.


immature T cell proliferation

description: The expansion of an immature T cell population by cell division.


immature T cell proliferation in thymus

description: The expansion of an immature T cell population by cell division in the thymus.


name: regulation of T cell differentiation in thymus

description: Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus.


name: regulation of extrathymic T cell differentiation

description: Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation.


name: regulation of immature T cell proliferation

description: Any process that modulates the frequency, rate or extent of immature T cell proliferation.


name: regulation of immature T cell proliferation in thymus

description: Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus.


name: negative regulation of T cell differentiation in thymus

description: Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus.


name: negative regulation of extrathymic T cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of extrathymic T cell differentiation.


name: negative regulation of immature T cell proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation.


name: negative regulation of immature T cell proliferation in thymus

description: Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus.


name: positive regulation of T cell differentiation in thymus

description: Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus.


name: positive regulation of extrathymic T cell differentiation

description: Any process that activates or increases the frequency, rate or extent of extrathymic T cell differentiation.


name: positive regulation of immature T cell proliferation

description: Any process that activates or increases the frequency, rate or extent of immature T cell proliferation.


name: positive regulation of immature T cell proliferation in thymus

description: Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus.


Weibel-Palade body

description: A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses.


description: Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O. The enzymatic part of the reaction produces 4-aminobutanal that spontaneously cyclizes to form 1-pyrroline.


aleurone grain

description: A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes.


amyloplast envelope

description: The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.


amyloplast membrane

description: Either of the lipid bilayers that surround an amyloplast and form the amyloplast envelope.


amyloplast inner membrane

description: The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma.


attachment organelle

description: A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division.


NuA3 histone acetyltransferase complex

description: A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p.


cellular bud membrane

description: The portion of the plasma membrane surrounding a cellular bud.


acidocalcisome membrane

description: The lipid bilayer surrounding an acidocalcisome.


name: protein secretion by the type VI secretion system

description: The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.


name: type VI protein secretion system complex

description: A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence.


chlorosome envelope

description: The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome.


cis-Golgi network membrane

description: The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network.


Cvt vesicle

description: A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p).


name: mitochondrial respiratory chain complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.


Cvt vesicle membrane

description: Either of the two lipid bilayers surrounding a Cvt vesicle, a vesicle that functions in the cytoplasm-to-vacuole targeting (Cvt) pathway.


attachment organelle membrane

description: The lipid bilayer surrounding an attachment organelle. This is a region of the cell membrane facing the environment - in mycoplasma, part of the mycolate outer membrane.


cyanelle envelope

description: The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space.


cyanelle membrane

description: Either of the lipid bilayers that surround a cyanelle and form the cyanelle envelope.


cyanelle thylakoid lumen

description: The volume enclosed by a cyanelle thylakoid membrane.


cyanelle thylakoid membrane

description: The lipid bilayer membrane of any thylakoid within a cyanelle.


name: endoplasmic reticulum-Golgi intermediate compartment membrane

description: The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.


esterosome

description: A vesicle filled with crystalline protein that shows sequence similarities with various esterases.


esterosome membrane

description: The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes.


negative regulation of RNA splicing

description: Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing.


positive regulation of RNA splicing

description: Any process that activates or increases the frequency, rate or extent of RNA splicing.


name: regulation of purine nucleotide catabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.


name: negative regulation of purine nucleotide catabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.


name: positive regulation of purine nucleotide catabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.


acetylcholine receptor binding

description: Binding to an acetylcholine receptor.


regulation of glucokinase activity

description: Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.


name: negative regulation of glucokinase activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.


name: positive regulation of glucokinase activity

description: Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.


ubiquitin activating enzyme binding

description: Binding to a ubiquitin activating enzyme, any of the E1 proteins.


name: regulation of peptidyl-serine phosphorylation

description: Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.


name: negative regulation of peptidyl-serine phosphorylation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine.


name: positive regulation of peptidyl-serine phosphorylation

description: Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.


name: regulation of peptidyl-serine phosphorylation of STAT protein

description: Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


name: negative regulation of peptidyl-serine phosphorylation of STAT protein

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


name: positive regulation of peptidyl-serine phosphorylation of STAT protein

description: Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


nuclear progesterone receptor binding

description: Binding to a nuclear progesterone receptor.


name: regulation of intracellular steroid hormone receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.


name: negative regulation of intracellular steroid hormone receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.


name: positive regulation of intracellular steroid hormone receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.


name: regulation of intracellular estrogen receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.


name: negative regulation of intracellular estrogen receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.


name: positive regulation of intracellular estrogen receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.


FFAT motif binding

description: Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family.


cytoskeletal calyx

description: A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins.


V(D)J recombination

description: The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).


immunoglobulin V(D)J recombination

description: The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined.


T cell receptor V(D)J recombination

description: The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).


name: ABC-type oligogalacturonide transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in).


oligogalacturonide transport

description: The directed movement of oligogalacturonides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: regulation of intracellular protein transport

description: Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.


name: mitogen-activated protein kinase kinase kinase kinase binding

description: Binding to a mitogen-activated protein kinase kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase kinase.


melanosome membrane

description: The lipid bilayer surrounding a melanosome.


microneme membrane

description: The lipid bilayer surrounding a microneme.


description: Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage.


interphotoreceptor matrix

description: A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance.


hyaline layer

description: A multilayered extraembryonic matrix that functions as a substrate for cell adhesion through early development. It is thought to protect and lubricate the embryo, stabilize the blastomeres during morphogenesis, and regulate nutrient intake. The major constituent of the hyaline layer is the protein hyalin. This matrix has been found in echinoderms.